Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 09/07

20070225480 - Novel sumo4 polypeptides and methods of use for type 1 diabetes: Novel nucleic acids associated with Type 1 diabetes. Also provided are polypeptides encoded by the nucleic acids associated with T1D. The invention also provides methods for facilitating the diagnosis or pre-diagnosis of T1D through the use of such nucleic acids and polypeptides. This invention further provides compositions for the treatment... Agent: Sutherland Asbill & Brennan LLP

20070225482 - Photoswitchable method for the ordered attachment of proteins to surfaces: Described herein is a method for the attachment of proteins to any solid support with control over the orientation of the attachment. The method is extremely efficient, not requiring the previous purification of the protein to be attached, and can be activated by UV-light. Spatially addressable arrays of multiple protein... Agent: The Regents Of The University Of California

20070219346 - Glucose sensor and uses thereof: The present invention provides a glucokinase protein in which the catalytic activity has been disabled in order to enable its use as a glucose sensor. The catalytically disabled glucokinase protein can be used as the glucose sensor in hand-held glucose monitors and in implantable glucose monitoring devices. The glucose sensor... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070219347 - Neisseria genomic sequences and methods of their use: The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria, including the amino acid sequences and the corresponding nucleotide sequences, as well as the genomic sequence of Neisseria meningitidis B. The proteins so obtained are useful antigens for vaccines, immunogenic compositions, and/or diagnostics... Agent: Novartis Vaccines And Diagnostics Inc.

20070219350 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Heller Ehrman LLP

20070219349 - Isolated gage-7b and 8 proteins: The invention relates to new members of the GAGE family referred to as GAGE-7B and GAGE-8. There are differences between these two molecules and the previously described members of the GAGE family on the genomic DNA, complementary DNA, and amino acid level.... Agent: Fulbright & Jaworski, LLP

20070219348 - Mutations in the mineralocorticoid receptor ligand binding domain polypeptide that permit structural determination of low affinity ligand complexes and screening methods employing same: An isolated mineralocorticoid receptor (MR) polypeptide, or functional portion thereof, having one or more mutations that alter the solubility or crystal-forming properties and confer the ability to generate soluble protein complexes with the MR and ligands that only weakly bind the native polypeptide, and a polynucleotide encoding it are disclosed.... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B475

20070219351 - Process for the preparation of doxorubicin conjugates with lactosaminated human albumin: A procedure is described for conjugating the hydrazone derivatives of doxorubicin having a maleimide terminal group to lactosaminated human albumin (L-HAS). The procedure is based on the use of trialkylphosphines to reduce the disulfide bonds of the protein and make its SH groups available for the formation of the thioether... Agent: Intellectual Property Group Fredrikson & Byron, P.A.

20070219352 - Fibrinogen from transgenic animals: The present invention provides a method for the part purification of fibrinogen from milk, the method comprising the transfer of protease enzyme which is present in the milk, into the whey phase with the removal or partition of fibrinogen into another phase of the milk. The present invention also provides... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070219353 - Immune response associated proteins: Various embodiments of the invention provide human immune response associated proteins (IRAP) and polynucleotides which identify and encode IRAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of IRAP.... Agent: Foley And Lardner LLP Suite 500

20070219354 - Assays using amyloid precursor proteins with modified beta-secretase cleavage sites to monitor beta-secretase activity: Provided are methods of identifying inhibitors of β-secretase that employ modified β-secretase substrates. The modified β-secretase substrates have β-secretase cleavage sites that are altered from wild type. The amino acid sequences of the altered β-secretase cleavage sites contain different amino acids in at least one of the positions P2-P1-P1′-P2′ of... Agent: Merck And Co., Inc

20070219355 - Compositions comprising sclareol or derivatives thereof and uses thereof: The present invention provides a composition which includes a sclareol or a derivative thereof, wherein the sclareol or a derivative thereof is bound by a glycoprotein matrix. The composition of the invention provides improved potency, stability and bioactivity characteristics of sclareol, or its derivatives.... Agent: Hoffmann & Baron, LLP

20070219356 - G-csf conjugates: e

20070219357 - Chemically modified g-csf:

20070219358 - Methods and systems for isolating target molecules from complex solutions by column-chromatography using eluants containing organic solvents: Various system and method embodiments of the present invention are directed to separating target molecules from complex solutions by affinity column chromatography using organic-solvent-containing eluants. In one embodiment of the present invention, an eluant containing an organic-solvent is used, at a first pH, to remove non-target solutes and suspended entities... Agent: Olympic Patent Works PLLC

20070213504 - Synthesis using peptide intermediate fragments: Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.... Agent: Roche Colorado Corporation

20070213505 - Solution synthesis of peptide cell growth stimulators: A solution phase synthetic method for preparing basic tripeptides of the formula Gly-Xaa-Gly-X which have in various biological properties such as stimulating protein production when used as additives in a bioreactor. The basic tripeptides of the invention may be produced on gram or kilogram scale.... Agent: Philip S. Johnson Johnson & Johnson

20070213506 - Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins: Methods and reagents for the formation of disulfide bonds, particularly in proteins, peptides and amino acids. The methods and reagents are particularly useful for the controlled glycosylation of proteins, peptides and amino acids. The methods utilise thiosulfonate or selenenylsulfide compounds as reagents or intermediates. Some proteins and peptides comprising selenenyl-sulfide... Agent: Blakely Sokoloff Taylor & Zafman

20070213507 - Methods and reagents for decreasing clinical reaction to allergy: It has been determined that allergens, which are characterized by both humoral (IgE) and cellular (T cell) binding sites, can be modified to be less allergenic by modifying the IgE binding sites. The IgE binding sites can be converted to non-IgE binding sites by masking the site with a compound... Agent: Choate, Hall & Stewart, LLP Patent Department

20070213508 - Compositions and methods comprising a ligand of chemerinr: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070213509 - Host receptor for pathogenic bacteria: A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events... Agent: Woodcock Washburn LLP

20070213510 - Compositions and methods comprising a ligand of chemerinr: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070213511 - Calicheamicin conjugation by antibody deglycosylation: The present invention provides processed for preparing a calicheamicin conjugate comprising removing glycosylation of a protein and reacting (i) an activated calicheamicin—hydrolyzable linker derivative and (ii) the deglycosylated protein. In one embodiment, the protein is an antibody, such as an anti-CD33 antibody (e.g., hp67.6), an anti-CD22 antibody (e.g., G544), an... Agent: Wyeth Patent Law Group

20070213512 - Amyloid beta peptide analogs and assemblies thereof: The present invention provides amyloid β peptide assemblies composed of at least three amyloid β peptide subunits, wherein at least one of the amyloid β peptide subunits is an amyloid β peptide analog. The invention further relates to metal complexes of amyloid β peptide assemblies and the use of amyloid... Agent: Licata & Tyrrell P.C.

20070213513 - Method for chromatographic purification: The present invention relates to a method of isolating a target compound from other components of a liquid, which method comprises at least two chromatographic steps, in any sequence of order, wherein the mobile phase is contacted with an affinity chromatography matrix and/or an ion-exchange chromatography matrix and/or a hydrophobic... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070208163 - Method for treatment of protein precipitates: The present invention relates to a method of washing and concentrating of protein precipitates by use of centrifugal forces. The proteins may be insulin, insulin analogues or insulin derivatives or GLP-1 or GLP-2 and analogues and derivates thereof such as acylated proteins.... Agent: Novo Nordisk, Inc. Patent Department