Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 07/07

20070173636 - Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation: The present invention provides a method for preparing polyfunctionalized peptides and/or proteins at non-adjacent designated sites via native chemical ligation. In certain embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more... Agent: Choate, Hall & Stewart LLP

20070173637 - Process for the preparation of perindopril using tetramethyluronium salts as coupling reagents: The present invention relates to the process for the preparation of the ACE inhibitor perindopril starting from stereospecific amino acid N-/1-(S)-ethoxy-carbonyl-butyl/-(S)-alanine which is activated with tetramethyluronium salts in the presence of tertiary organic base, following the reaction with (2S,3aS,7aS)-octahydroindolo-2-carboxylic acid or an ester thereof, and after completing the reaction followed... Agent: Novartis Corporate Intellectual Property

20070173638 - Method of providing a purified, virus safe antibody preparation: A method of preparing a purified, virus inactivated and virus safe antibody preparation from a starting solution comprising antibodies and contaminants, the method comprising the steps of: (a) adjusting the pH of the starting solution to about 4.6 to about 4.95 in particular to about 4.8 to about 4.95 to... Agent: Venable LLP

20070173639 - Method for the preparation of phytosterols from tall oil pitch: A method of preparing phytosterols from tall oil pitch containing steryl esters comprises the steps of converting the steryl esters to free phytosterols while in the pitch to produce a modified pitch containing the free phytosterols; removing light ends from the modified pitch by evaporation to produce a bottom fraction... Agent: Moore & Van Allen PLLC

20070167609 - Nanoscale array biomolecular bond enhancer device: The invention teaches the use of an addressable nanoscale device to create a programmable substrate useful in selectively attracting proteins, nucleating protein crystals and growing protein crystals of a size amenable to diffraction analysis. Further taught is the use of nanoscale assemblies to create charge patterns, where such charge patterns... Agent: Deborah Neville

20070167611 - Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function: The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds... Agent: Banner & Witcoff, Ltd.

20070167610 - Recombinant soluble adenovirus receptor: The invention provides recombinant human CAR (coxsackievirus and adenovirus receptor) polypeptides which bind adenovirus. Specifically, polypeptides corresponding to adenovirus binding domain D1 and the entire extracellular domain of human CAR protein comprising D1 and D2 are provided. In another aspect, the invention provides nucleic acid sequences encoding these domains and... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20070167608 - Sugar chain structure profiling techniques: The present inventors discovered that lectins recognize extremely small differences in sugar chain structures, and that by using this ability to recognize sugar chain structures, numerous sugar chain structures can be distinguished using the strong or weak interaction patterns of about ten types of lectins. Therefore, by reference to and... Agent: Darby & Darby P.C.

20070167607 - Use of soluble forms of cd83 and nucleic acids encoding them for the treatment or prevention of diseases: The present invention provides for the use of soluble forms of CD83 and nucleic acids encoding them for the treatment of diseases caused by the dysfunction or undesired function of a cellular immune response involving dendritic cells, T cells and/or B cells. The invention moreover provides soluble CD83 molecules specifically... Agent: Norris, Mclaughlin & Marcus, Pa

20070167612 - Polishing steps used in multi-step protein purification processes: Various embodiments of the present invention are directed to multi-step systems and methods for target-molecule purification that employ column-chromatography-based and/or membrane-filtration-based polishing steps. In one described embodiment of the present invention, a target-protein-containing eluate having a high residual salt concentration is collected from a first chromatography column prepared with an... Agent: Olympic Patent Works PLLC

20070167613 - Process for the purification of antibodies: The present invention relates to a process for the purification of antibodies from one or more impurities in a liquid, which process comprises contacting said liquid with a first chromatography resin comprised of a support to which multi-modal ligands have been immobilised to adsorb the antibodies to the resin, wherein... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070161778 - Use of acid scavengers for the synthesis of standard lenght and long-mer nucleic acid arrays: Protective groups which may be cleaved with an activatable deprotecting reagent are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070161779 - Estrogen extraction from pregnant animal urine: A method of extracting oestrogens, conjugated estrogens, equine gonadotropin and equine follicle stimulant from pregnant mares urine which includes the steps of contacting the urine with dispersed particles of adsorber materials of a particle size above 200 microns and subsequently removing the species by washing the adsorber materials in a... Agent: Connolly Bove Lodge & Hutz LLP

20070161780 - Purification of peptides from colostrum: The invention relates to the purification of peptides from colostrum. The method involves the addition of an alcohol such as methanol or ethanol to the mixture in order to form an alcohol phase rich in the peptides, and a precipitate. The peptide-rich alcohol phase is subsequently recovered and subjected to... Agent: Rankin, Hill, Porter & Clark, LLP

20070161781 - Therapeutic human albumin solutions with low prekallicrein activator (pka) activity and process for obtaining them: The invention discloses a purified albumin solution of human origin with low prekallicrein activator (PKA) activity and stability over time characterised in that it has an antithrombin content equal to or greater than 0.03 mg/g of albumin, and a process for production thereof by the partial extraction of the antithrombin... Agent: Darby & Darby P.C.

20070161783 - Optimized proteins that target ep-cam: Humanized Ep-CAM-targeting antibodies and methods of making and using the same are provided.... Agent: Morgan, Lewis & Bockius, LLP

20070161782 - Peptides for detection of antibody to ehrlichia ewingii: The invention provides compositions and methods for the detection and quantification of Ehrlichia ewingii, Ehrlichia ewingii antibodies, antibody fragments, and polypeptides.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070161785 - High density metal ion affinity compositions and methods for making and using the same: High density metal ion affinity compositions and methods for making and using the same are provided. The subject compositions include a matrix bonded to ligand/metal ion complexes, where the compositions have a high metal ion density. The subject compositions find use in a variety of different applications. Also provided are... Agent: Bozicevic, Field & Francis LLP

20070161784 - Methods and products of amino acid isolation: Embodiments of the present invention provide processes for extracting amino acids from mixtures of amino acids, and compositions and mixtures formed therefrom. Applications include separating and/or isolating non-aromatic amino acids, and/or separating aromatic amino acids into at least one fraction containing phenylalanine and tryrosine and a fraction containing L-β-3-indolylalanine (L-β-3)... Agent: Schwabe, Williamson & Wyatt, P.C. Pacwest Center, Suite 1900

20070155955 - Amylin aggregation inhibitors and use thereof: Short peptides and derivatives or analogs thereof for the treatment or prevention of IAAP related disorders, in particular amyloid deposits associated with Type I or Type II diabetes are herein described. These peptides and/or their derivatives have been designed to inhibit the formation of amylin fibrils which are implicated in... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070155957 - Crystals of marr polypeptides, regulators of multiple antibiotic resistance: The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described.... Agent: Lahive & Cockfield, LLP

20070155956 - Preparation of antifreeze protein: A method is provided for increasing the specific activity of a type III antifreeze protein when said protein is prepared by expression in a heterologous fungal species of a gene encoding the protein sequence, by means of reducing the extent of glycosylation of the protein.... Agent: Morgan Lewis & Bockius LLP

20070155958 - Tnf-like secreted protein: This invention relates to novel protein INSP058, herein identified as TNF-like secreted protein, and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention, and treatment of disease.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070155959 - Protease inhibitor conjugates and antibodies useful in immunoassay: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal... Agent: Roche Diagnostics Operations Inc.