Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 05/07

20070123696 - G-csf conjugates: The invention relates to polypeptide conjugates comprising a polypeptide exhibiting G-CSF activity and having an amino acid sequence that differs from the amino acid sequence of human G-CSF in at least one specified introduced and/or removed amino acid residue comprising an attachment group for a non-polypeptide moiety, and having at... Agent: Maxygen, Inc. Intellectual Property Department

20070123697 - Process for purifying interferon beta: Provided is a process for purifying human interferon beta from a recombinant human interferon beta-containing culture comprising performing affinity chromatography and cation exchange chromatography, wherein the affinity chromatography includes: adsorbing the interferon beta-containing culture to an equilibrated affinity chromatography column, followed by washing with an equilibration buffer solution; washing the... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070123698 - Process for purification of hemoglobin: The present invention provides a method for purifying hemoglobin from red blood cells, wherein the red blood cells are deep-frozen and preserved, and then purified.... Agent: Dickstein Shapiro LLP

20070123699 - Peptide conjugate useful for cell nucleus molecular imaging and tumor therapy: Described is a conjugate comprising (a) an amphiphilic transport peptide of human origin as a transmembrane module (TPU), (b) a nuclear localization sequence (NLS) and (c) a signalling and/or drug carrying module (SM), preferably comprising Gd, Ga, Fe, Mn, I and/or F as (diagnostic) image creating compound. Said conjugate is'... Agent: Howrey LLP

20070123700 - Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction: Methods for decellularizing mammalian tissue for use in transplantation and tissue engineering. The invention includes methods for simultaneous application of an ionic detergent and a nonionic detergent for a long time period, which may exceed five days. One method utilizes SDS as the ionic detergent and Triton-X 100 as the... Agent: Katharine A. Jackson Huebsch Medtronic, Inc.

20070117965 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070117966 - Alphanubeta3 integrin-binding polypeptide monobodies and their use: The present invention relates to a polypeptide monobody which includes a modified acid sequence and renders the polypeptide monobody able to bind selectively to αvβ3 integrin. Fusion proteins and conjugates which include the polypeptide monobody, as well as compositions containing the polypeptide monobody, fusion proteins, or conjugates are also disclosed.... Agent: Edwin V Merkel Nixon Peabody

20070117967 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070112174 - Peptides capable of binding to titanium silver silicone: The present invention provides a peptide sequence, a phage, an artificial protein or a chimeric molecule having a binding ability to titanium, silver, silicon, necessary to confer higher capacity of titanium, silver, silicon material with the use of soft matters, or to provide a complex of a peptide, a phage,... Agent: Morgan & Finnegan, L.L.P.

20070112177 - Adenosine receptor: The present invention provides an isolated mammalian adenosine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070112175 - Determining drug resistance: A method for inducing in a cell a resistance to an anti-microtubule agent comprising the step of providing in a cell, a nucleic acid molecule that encodes a mutant actin, or providing in a cell, a mutant actin.... Agent: Davis Wright Tremaine LLP

20070112176 - Lipid membrane structure containing anti-mt-mmp monoclonal antibody: A lipid membrane structure containing an anti-membrane-type matrix metalloproteinase monoclonal antibody such as an anti-MT1-MMP monoclonal antibody as a component of the lipid membrane structure. Said structure can be utilized as a drug delivery system for efficiently delivering a medicinally active ingredient and/or a gene to tumor cells, neoplastic vessel... Agent: Greenblum & Bernstein, P.L.C

20070112178 - Antibody purification: The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support to which multi-modal ligands have been immobilised, wherein a multi-modal ligand comprises at least one cation-exchanging group and at least one... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070112179 - Novel compounds: An antibody, or a derivate or a fragment thereof, having a binding structure for a target structure is described. The antibody is displayed in, and on the cell surface of, human gastrointestinal epithelial tumour cells and in a subpopulation of normal human gastrointestinal epithelial cells. Said binding structure comprises the... Agent: Buchanan, Ingersoll & Rooney PC

20070112180 - Detection of biomolecules by sensitizer-linked substrates: Methods and compositions for detecting and characterizing target biomolecules using sensitizer-linked substrate molecules are disclosed. High throughput screening assays and therapeutic applications of the inventions are also included.... Agent: Lisa A. Haile, Ph.d. Dla Piper US LLP

20070112181 - Method for enrichment/seperation of protein or peptide: The present invention finds a media that can highly selectively retain proteins or peptides to be enriched/separated, as well as provides a method for selectively enriching/separating proteins or peptides using such a media. A method for enrichment/separation of a protein or a peptide, comprising separating a protein or a peptide... Agent: Rader Fishman & Grauer PLLC

20070106062 - Attenuated vif dna immunization cassettes for genetic vaccines: The present invention is directed to nucleic acid molecules encoding attenuated, non-functional virion infectivity factor (vif) proteins. The nucleic acid molecules of the invention are inserted into recombinant expression vectors and administered to mammals in order to induce a cellular and humoral immune response to the encoded protein product.... Agent: Pepper Hamilton LLP

20070106063 - Method for extracting insulins by improved air-gassing of a folding: The present invention comprises a process for preparing insulin or an insulin derivative with correctly linked cysteine bridges from a precursor of said insulin or insulin derivative, wherein said precursor is subjected to a folding process in the presence of cysteine or cysteine hydrochloride and a chaotropic auxiliary compound. The... Agent: Ross J. Oehler Sanofi-aventis U.s. LLC

20070106064 - Solid phase method for synthesis peptide-spacer-lipid conjugates, conjugates synthesized thereby and targeted liposomes containing the same: A solid phase synthesis method for preparing peptide-spacer-lipid conjugates, the peptide-spacer-lipid conjugates synthesized by the method, and liposomes containing the peptide-spacer-lipid conjugates. The present invention provides a convenient solid phase synthesis method for preparing peptide-spacer-lipid conjugates and provides various linkage groups (such as amide group) for conjugating peptide, spacer and... Agent: Ladas & Parry

20070106065 - Tat- 001 and methods of assessing and treating cancer: Surprisingly, the present inventors have discovered that expression of TAT-001 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-001 is associated with abnormal development and growth, and may be useful as a... Agent: Clark & Elbing LLP

20070106066 - Cherkasky fusion proteins containing antibody-, antigen- and microtubule-binding regions and immune response-triggering regions: The invention relates to the fields of tumour physiology and biotechnology. The object of the invention is to develop effective and selective novel fusion proteins and fusion protein-antibody complexes against various types of leukaemia and solid tumours. Selectivity is achieved by cell-specific or tumour-specific ligands of the fusion proteins or... Agent: Brooks Kushman P.C.

20070106067 - Assay kit and antibody for human low molecular weight cd14: The present invention provides an antibody prepared using a peptide as an antigen, the peptide having 8 to 30 amino acid residues selected from an amino acid sequence at positions 1 to 68 of human high-molecular-weight CD14, or an antibody that binds to a peptide having a specific amino acid... Agent: Birch Stewart Kolasch & Birch

20070100133 - Erythropoietic compounds: The present invention addresses the need for better pharmaceutical agents for teating anemias by providing polymer derivatized non-glycosylated erythropoietic compounds which show stability and bioactivity in vivo. The invention further provides methods for preparing these derivatived proteins which involves the use of a linkerless aldehyde modification process.... Agent: Eli Lilly & Company

20070100134 - Coral purification method and coral thus obtained: The present invention provides a method of extracting organic substances present in coral, which consists in treating the coral with a fluid or a mixture of fluids in the supercritical state without modifying the crystalline structure of said coral, at a temperature of less than 270° C. and at a... Agent: Dennison, Schultz & Macdonald