Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 02/07

20070043206 - Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol: P

20070043207 - Novel coupling agent and uses thereof: Novel phosphonium salts of benzotraizoles, which are highly reactive coupling agents, and are particularly useful in peptide synthesis, are disclosed. Further disclosed is a process of preparing the novel phosphonium salts and methods utilizing same for preparing peptides.... Agent: Martin Moynihan Prtsi Inc

20070043208 - Crystal structure of erythrocyte binding domain of eba-175: The present invention provides three-dimensional structural information for region II of the erythrocyte binding antigen 175 (EBA-175). Specifically, the present invention provides three-dimensional structural information of erythrocytic receptor binding sites of EBA-175 RII. The three-dimensional structural information is useful in drug design aimed at blocking receptor interaction with EBA-175. Methods... Agent: Leopold Presser Scully, Scott, Murphy & Presser

20070043210 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070043209 - Interferon-like protein zcyto21: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070043211 - Mammalian transforming growth factor beta-9: Novel mammalian Ztgfβ-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070043212 - Crown ether derivatives: The invention describes crown ether chelaters including crown ethers having the formula:... Agent: Invitrogen Corporation C/o Intellevate

20070037964 - Chemoselective ligation: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety,... Agent: Bozicevic, Field & Francis LLP

20070037963 - Differentially protected orthogonal lanthionine technology: The present invention provides a method of synthesizing an intramolecularly bridged polypeptide comprising at least one intramolecular bridge. The present invention further provides a method of synthesizing an intramolecularly bridged polypeptide comprising two intramolecular bridges, wherein the two intramolecular bridges form two overlapping ring, two rings in series, or two... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070037965 - Interleukin-17 receptor homologue: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”... Agent: Zymogenetics, Inc. Intellectual Property Department

20070037966 - Hydrophobic interaction chromatography purification of factor vii polypeptides: The invention described herein provides new methods of preparing purified Factor VII polypeptide drug substances in large quantities (industrial scale levels) that are associated with reduced content of product-related impurities (e.g., late eluting peaks) and/or that exhibit a relatively uniform glycosylation pattern.... Agent: Novo Nordisk, Inc. Patent Department

20070037967 - Polypeptide and protein derivatives and process for their preparation: Protein and polypeptide derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the formula —C(R)═N— (or —N═C(R)—) or —CH(R)—NH— (or —NH—CH(R)—), wherein R is hydrogen or a hydrocarbon residue which may be substituted, with... Agent: James E. Butler, Ph.d., Esq Amylin Pharmaceuticals, Inc.

20070032636 - Chimeric retroviral gag genes and screening assays: The subject invention provides novel and advantageous methods for identifying amino acid sequences in random peptide libraries that can bind to Gag polypeptides. The subject invention also establishes a novel in vitro system that can be used to test competitive inhibitors of retroviral capsid assembly. Also provided are peptides, and... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070032635 - Prevention and treatment of hcv infection employing antibodies directed against conformational epitopes: Conformational epitopes of the envelope protein E2 of the Hepatitis C virus (HCV) have been identified and characterized using a panel of monoclonal antibodies derived from patients infected with HCV. These conformational epitopes have been determined to be important in the immune response of humans to HCV and may be... Agent: Choate, Hall & Stewart LLP

20070032637 - Egf/egfr complex: The present invention relates to a crystal of a complex of an epidermal growth factor (EGF) and an epidermal growth factor receptor (EGFR), a crystal of a complex of EGFR and a substance regulating EGFR activity, structure coordinates of these crystals, a method for screening for the substance regulating EGFR... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070032639 - Identification of new small rnas and orfs of e. coli as mediators of cell and intercell regulation: The invention relates to new small RNAs and ORFs of E. coli as mediators of cell and intercell regulation.... Agent: Knobbe, Martens, Olson & Bear, LLP

20070032638 - Method for the purification of a non-immunoglobulin protein comprising an immunoglobulin-like (ig-like) domain: The present invention relates to a method for the purification of non-immunoglobulin proteins comprising one or more immunoglobulin-like (Ig-like) domain.... Agent: David S. Resnick

20070032640 - Cytokine receptor: A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or variants thereof. Also provided arc methods of modulating an IL-6 receptor comprising contacting... Agent: Foley And Lardner Suite 500

20070027303 - Metal chelate complexes immobilized on solid supports for peptide preparation: Use of an activated solid phase and an anchoring part which is attached to a peptide for solid phase peptide synthesis, wherein the anchoring part is coordinatively and reversibly attached to the activated solid phase. Furthermore provided is a process for competitively detachment of said anchoring part, for purification and... Agent: Sterne, Kessler, Goldstein & Fox PLLC

20070027304 - Mammalian iap gene family, primers, probes and detection methods: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes.... Agent: Philip Swain, Phd C/o Gowling Lafleur Henderson

20070027305 - Method and system for in vitro protein folding: A method of recovering a refolded protein involves static mixing a concentrated solution of a denatured protein with a refolding diluent to obtain the refolded protein. The method is particularly suitable for microbially produced recombinant proteins in large processing volumes. The denatured protein solution can be obtained by isolating protein... Agent: Novartis Vaccines And Diagnostics Inc.

20070027306 - Albumin fusion proteins: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070027307 - Microwave method for preparing radiolabelled gallium complexes: The present invention relates to a method of producing radiolabelled gallium complexes that could be used as diagnostic agents, e.g. for positron emission tomography (PET) imaging.... Agent: Ge Healthcare, Inc.