Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 01/07

20070021588 - Alpha macroglobulin protein family members: This invention relates to two proteins, termed INSP087, herein identified as members of the alpha macroglobulin family, in particular as alpha-2-macroglobulin-like proteinase inhibitors, and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070021591 - Compositions and methods for protein deaggregation: Compositions and methods are provided for achieving the deaggregation of binding proteins including, but not limited to, protein ligands, soluble receptors, antibodies, antibody fragments, variable fragment single-chain antibodies (scFv), and small modular immunopharmaceutical products (SMIP™ products). The compositions, which are suitable for the deaggregation of highly concentrated solutions of binding... Agent: Speckman Law Group PLLC

20070021592 - Npc1l1 (npc3) and methods of use thereof: The present invention provides human, rat and mouse NPC1L1 polypeptides and polynucleotides encoding the polypeptides. Also provided are methods for detecting agonists and antagonists of NPC1L1. Inhibitors of NPC1L1 can be used for inhibiting intestinal cholesterol absorption in a subject.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070021589 - Obesity-related genes: The present invention relates generally to a nucleic acid molecule which is expressed in at least red gastrocnemius muscle or its equivalent under particular physiological conditions. It is proposed that the nucleic acid molecule is differentially expressed under differing conditions of healthy state, myopathy, obesity, anorexia, weight maintenance, diabetes, disorders... Agent: Scully, Scott, Murphy & Presser

20070021590 - Secreted protein family: This invention relates to a new family of secreted proteins, termed the SECFAMI family, its family members including the novel proteins INSP113, INSP114, INSP115, INSP116 and INSP117, herein identified as secreted proteins containing epidermal growth factor (EGF) fold-containing domains, ranging from 125-153 amino acids in length and containing eight conserved... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070021593 - High-affinity antagonists of elr-cxc chemokines: The present invention provides novel polypeptide sequences, methods for production thereof and uses thereof for novel ELR—CXC chemokine receptor agonists and antagonists.... Agent: Ade & Company Inc.

20070021594 - Ligand-binding reagents for quenching and improved purification of lipidated proteins: This invention describes a method for removing unreacted activated lipid moieties using a bifunctional ligand containing a first functional group reactive with the activating group of the lipid and a second functional group capable of binding to an affinity reagent or support. These reagents can be used to quench reactions... Agent: Philip S. Johnson Johnson & Johnson

20070021595 - Humanized antibody amd process for preparing same: A humanized antibody is produced by process comprising the steps of: (a) selecting a specificity determining residue (SDR) of the complementarity determining region (CDR) of murine monoclonal antibody heavy chain and light chain variable regions; and (b) grafting said SDR to at least one of the corresponding amino acid sequences... Agent: Anderson, Kill & Olick, P.C.

20070021596 - Tick galectin: A novel galectin, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the galectin, and a screening method for screening a substance capable of modifying the galectin, are disclosed. According to the galectin, polynucleotide, or vector, it is possible, for example, to exterminate... Agent: Sughrue Mion, PLLC

20070015904 - Process for obtaining fatty acid alkyl esters, rosin acids and sterols from crude tall oil: The disclosed invention provides a process for obtaining fatty acid alkyl esters, rosin acids and sterols from crude tall oil (CTO), characterised in that the CTO is subjected to the following steps: (a) reacting the free fatty acids present in the CTO with lower alcohols; (b) separating the fatty acid... Agent: Cognis Corporation Patent Department

20070015905 - 2' and 3'-nucleoside prodrugs for treating flaviviridae infections: 2′ and 3′-Prodrugs of 1′, 2′, 3′ or 4′-branched β-D or β-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C... Agent: King & Spalding

20070015908 - 123 human secreted proteins: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing... Agent: Human Genome Sciences Inc Intellectual Property Dept.

20070015909 - Adiponectin variants: Adiponectin variants comprising one or more amino acid modifications to corresponding wild-type adiponectins at positions having predetermined hydrophobicity, predetermined polarity, predetermined electrostatic potential, Met, aromatic amino acid, Cys corresponding to position 152 of SEQ ID NO:1, amino acid affecting isoelectric point of the wild-type or variant adiponectin, amino acid affecting... Agent: Hogan & Hartson L.L.P.

20070015906 - Novel essential fungal polynucleotides, polypeptides, and methods of use: The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.... Agent: Stephen B. Davis Bristol-myers Squibb Company

20070015907 - Repeat sequences of the ca125 gene and their use for diagnostic and therapeutic interventions: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a... Agent: Susan B Fentress Butler Snow O'mara Steven & Cannada

20070015910 - Continuous process for production of oil seed protein isolate: Oil seed protein isolates, particularly canola protein isolate, are produced continuously from oil seed meals, preferably at a high purity level of at least about 100 wt % (N×6.25), by a process wherein oil seed protein is continuously extracted from oil seed meal, the resulting protein solution is continuously concentrated,... Agent: Sim & Mcburney

20070015911 - Methods for biomarker discovery and diagnostic screening: The subject invention relates to methods of profiling biomolecules from mammalian biological samples, for example, plasma or serum, in order to discover markers of disease, treatment, toxicity or efficacy. The resulting profiles may be used, for instance, to discover novel markers or patterns that may be used to classify samples... Agent: Robert Deberardine Abbott Laboratories

20070010655 - Stationary phases and a purification process using the stationary phases: This invention relates to a novel stationary phase of Formula I and a method for purifying a peptide or lipopeptide in liquid chromatography using select stationary phases, including the stationary phases of Formula I to improve the resolution and/or productivity of the purification. This chromatographic method can be used for... Agent: Merck And Co., Inc

20070010656 - Novel exendin agonist compounds: Novel exendin agonist compounds are provided. These compounds are useful in treating Type I and II diabetes and conditions which would be benefited by lower plasma glucose and delaying and/or slowing gastric emptying... Agent: Arnold & Porter LLP (18528) Attn IPDocketing Dept.

20070010657 - Cytoplasmic dynein heavy chain 1 genes, expression products, non-human animal model uses in human neurological diseases: A non-human animal model is provided, particularly a mouse model for movement hyperactivity, excitoxicity disorders (e.g. myoclonic cramping) and neurodegeneration, in which modified cytoplasmic dynein heavy chain1 is expressed. Modified human and mouse cytoplasmic dynein heavy chain1 proteins and nucleic adds are also provided, including the corresponding recombinant proteins. The... Agent: Fish & Richardson PC

20070010658 - Trimeric binding proteins for trimeric cytokines: The present invention pertains to the provision of trimeric binding units which bind to trimeric cytokines. In particular there is provided a trimeric polypeptide comprising a trimerising domain and three monomers with binding members capable of binding a trimeric cytokine. Preferably, the trimeric binding units bind in a manner such... Agent: Hunton & Williams LLP Intellectual Property Department

20070010659 - Adiponectin variants: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.... Agent: Hogan & Hartson L.L.P.

20070010660 - G-csf conjugates: Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a low in vitro bioactivity, a long in vivo... Agent: Maxygen, Inc. Intellectual Property Department

20070010661 - Methods for purifying protein: A method is provided for separating a protein from one or more other proteins using hydroxyapatite chromatography in which the protein does not bind to hydroxyapatite but the other protein(s) does. In some embodiments, a second protein affixed to a solid support has been used previously to purify the protein... Agent: Immunex Corporation Law Department

20070010662 - Vgf fusion polypeptides: The present invention provides novel VGF polypeptides and selective binding agents. The invention also provides host cells and methods for producing VGF polypeptides. The invention further provides VGF pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, conditions, and disorders associated with VGF polypeptides.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070004904 - G-csf conjugates: The invention relates to polypeptide conjugates comprising a polypeptide exhibiting G-CSF activity and having an amino acid sequence that differs from the amino acid sequence of human G-CSF in at least one specified introduced and/or removed amino acid residue comprising an attachment group for a non-polypeptide moiety, and having at... Agent: Maxygen, Inc. Intellectual Property Department

20070004905 - Solid-phase peptide synthesis and agent for use in such synthesis: The present invention relates to an improved process for the production of peptides by solid-phase synthesis. The invention also relates to agents which are useful in solid-phase peptide synthesis.... Agent: Clark & Elbing LLP

20070004906 - Novel antagonists of mcp proteins: Novel antagonists of MCP proteins, in particular of MCP-1 protein, can be obtained by generating MCP mutants whose GAG binding site, located at the N-terminal of MCP proteins, is eliminated following non-conservative substitutions. Compounds prepared in accordance with the present invention can be used in the treatment or prevention of... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070004907 - Genes conferring herbicide resistance: Compositions and methods for conferring herbicide resistance to plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a polypeptide that confers resistance or tolerance to glyphosate herbicides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression... Agent: Alston & Bird LLP

20070004908 - Production of canola protein: A canola protein isolate having a protein content of at least about 90 wt % (N×6.25), preferably at least about 100 wt %, and consisting predominantly of the 2S protein and substantially free from the 7S and 12S proteins is prepared. In one aspect, canola oil seed meal is extracted... Agent: Sim & Mcburney

20070004910 - Hk1-binding proteins: The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides.... Agent: Fish & Richardson PC

20070004909 - Covalent diabodies and uses thereof: The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which... Agent: Jones Day