Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 12/06

20060293505 - Crystal of a truncated protein construct containing a coagulation factor viii c2 domain in the presence or absence of a bound ligand and methods of use thereof: A detailed three-dimensional structure for the C-terminal C2 domain of blood coagulation factor VIII is disclosed. The novel truncated factor VIII constructs which were designed so as to omit a significant portion of the flexible full length protein are also part of the present invention. In addition, the crystals of... Agent: Townsend And Townsend And Crew, LLP

20060293506 - Antibodies directed to pdgfd and uses thereof: The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin... Agent: Curagen Corporation

20060293507 - Crystallization of igf-1: Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising a precipitant to form a mixture; and crystallizing the mixture, optionally also recrystallizing and isolating the crystalline IGF-1. In addition, a method... Agent: Heller Ehrman LLP

20060287500 - Method for synthesis of c2-symmetric diamino diol mediated by titanium complexes: A method for synthesis of C2-symmetric diamino diol mediated by titanium complexes is provided. A substituted-L-phenylalaninal undergoes pinacol coupling to yield the corresponding C2-symmetric (1S,2R,3R,4S)-1,4-diamino 2,3-diol in the presence of Cp2TiCl2/ZnCl2 and zinc metal, mediated in good yield and highly selective. This titanium-catalyzed reaction yields diaminodiol, offering a convenient alternative... Agent: Birch Stewart Kolasch & Birch

20060287502 - C3b/c4b complement receptor-like molecules and uses thereof: Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.... Agent: Marshall, Gerstein & Borun LLP

20060287503 - Retinoid x receptor-interacting polypeptides and related molecules and methods: Disclosed is purified DNA encoding retinoid X receptor-interacting proteins and methods for producing RXR-interacting proteins expressed from such DNA.... Agent: Clark & Elbing LLP

20060287501 - Soluble truncated polypeptides of the nogo-a protein: The present invention refers to an isolated truncated Nogo-A polypeptide that corresponds to a truncated form of the Nogo-A protein consisting of the amino acids 174 to 940 of the full length protein of rat Nogo-A or of the amino acids 246 to 966 of the human full length Nogo-A... Agent: Foley And Lardner LLP Suite 500

20060287504 - Universal procedure for refolding recombinant proteins: A universal folding method that has been demonstrated to be effective in refolding a variety of very different proteins expressed in bacteria as inclusion bodies has been developed. Representative proteins that can be dissolved and refolded in biologically active form, with the native structure, are shown in Table I. The... Agent: Morrison & Foerster LLP

20060287505 - Mammalian cytokine-like polypeptide-10: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.... Agent: Zymogenetics, Inc. Intellectual Property Department

20060287506 - Method for separating and concentrating biological materials using continuous-flow ultracentrifugation: The present invention is directed to a method of isolating and concentrating biological materials based on their buoyant density by subjecting a sample containing the biological materials to density-gradient ultracentrifugation. In one aspect of the present invention, a method for isolating at least one biological material is provided. A sample... Agent: Sonnenschein Nath & Rosenthal LLP

20060287507 - Mammalian cytokine-like polypeptide-10: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.... Agent: Zymogenetics, Inc. Intellectual Property Department

20060287508 - Methods for stabilizing proteins: The present inventors revealed that deamidation of an antibody can be suppressed without influencing its activity by substituting a glycine that is located adjacent to an asparagine with another amino acid.... Agent: Fish & Richardson PC

20060287509 - Novel high affinity human antibodies to tumor antigens: This invention provides for novel human antibodies that specifically bind to c-erbB-2. The antibodies may be used alone or as components of chimeric molecules that specifically target and deliver effector molecules to cells overexpressing c-erbB-2.... Agent: Beyer Weaver & Thomas, LLP

20060287510 - Crystallization of igf-1: Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising a precipitant to form a mixture; and crystallizing the mixture, optionally also recrystallizing and isolating the crystalline IGF-1. In addition, a method... Agent: Heller Ehrman LLP

20060287511 - Process for producing zinc oxide-protein complex: An object of the present invention is to obtain a zinc oxide-protein complex which can be a source of nanoparticles of zinc oxide utilizing a protein having a cavity inside thereof The process for producing a zinc oxide-protein complex according to the present invention includes a hydrogen peroxide addition step... Agent: Mcdermott Will & Emery LLP

20060281897 - Potentialization of the activation of high molecular weight prodrugs: This invention is directed to a modified form of a prodrug. A typical form of prodrug according to the invention comprises a bulky group, a spacer, a structure that can be cleaved at or near the target cells and a therapeutic agent or a marker, whereby the spacer allows or... Agent: Hunton & Williams LLP Intellectual Property Department

20060281898 - Method for the production of plant seed with modified fibre content and modified seed coat: The present invention relates to a nucleotide sequences commonly designated CJAS1 comprising a novel gene from plants. The novel gene encodes a protein that is involved in seed formation and is associated with plant defense. The invention further relates to the use of the nucleotide sequence in the sense or... Agent: Trask Britt

20060281902 - Human signal peptide-containing proteins: The invention provides a human signal peptide-containing proteins (SIGP) and polynucleotides which identify and encode SIGP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of SIGP.... Agent: Foley And Lardner LLP Suite 500

20060281900 - Lepidoptera voltage-gated calcium channels: Novel nucleic acid sequences encoding lepidoptera calcium channel subunits, and recombinant expressions and host cells comprising the same are disclosed. Isolated lepidoptera calcium channel subunits, host cells expressing a lepidoptera calcium channel subunits, methods of producing the lepidoptera calcium channel subunits and antibodies specific for the lepidoptera calcium channel subunits... Agent: Fmc Corporation Patent Administrator

20060281901 - Method for the production of amyloid-beta peptide using ubiquitin: The method for the production of amyloid-β peptide using ubiquitin as a fusion partner according to the present invention overcomes such problems of chemical methods for synthesizing amyloid-β peptide as low yield and high production cost, and can be effectively used for producing amyloid-β peptide in a high yield.... Agent: David A. Einhom, Esq. Anderson Kill & Olick, P.C.

20060281899 - Mutants of biotin binding protein: The present invention relates to new mutants of biotin binding proteins with improved properties, e.g., thermally stabilized compared to wild type proteins. Proteins, which bind biotin include chicken avidin and bacterial streptavidin, other poultry avidins, such as avidin proteins isolated from the duck, goose, ostrich and turkey, and chicken avidin-related... Agent: Young & Thompson

20060281903 - Process for producing albumin preparation: An albumin preparation may be produced efficiently on a commercial basis that has reduced possibility of contamination of infectious viruses and has high safety and stability. The process according to the present invention comprises a step of filtration of a serum albumin-containing solution with a virus-removing membrane preferably with a... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20060281904 - Colur reduction in canola protein isolate: In the recovery of canola protein isolates from canola oil seeds steps are taken to inhibit the formation of colouring components and to reduce the presence of materials tending to form colouring components, to obtain a lighter and less yellow canola protein isolate.... Agent: Sim & Mcburney

20060281905 - Crystallization of igf-1: Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising a precipitant to form a mixture; and crystallizing the mixture, optionally also recrystallizing and isolating the crystalline IGF-1. In addition, a method... Agent: Heller Ehrman LLP

20060281906 - Methods and kits for purifying his-tagged proteins: Disclosed are methods of separating a target molecule from a non-target molecule using zinc- or cobalt-charged solid supports.... Agent: Michael Best & Friedrich, LLP

20060276621 - Glycosylated specificity exchangers: The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and methods of using said specificity exchangers to treat or prevent human disease are described herein....

20060276622 - Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing: The technical problem underlying the present invention is to provide peptides corresponding to immunologically important epitopes on bacterial and viral proteins, as well as the use of said peptides in diagnostic or immunogenic compositions. The invention relates to a process for the in vitro determination of antibodies, wherein the peptides...

20060276623 - Semi-synthetic glycopeptides with antibiotic activity: Semi-synthetic glycopeptides having antibacterial activity are based on modifications of the eremomycin, A82846B, vancomycin, teicoplanin, and A-40,926 scaffolds, in particular, acylation of the sugar moieties on these scaffolds with certain acyl groups; and/or conversion of an acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides; or...

20060276624 - Synthesis using peptide intermediate fragments: Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield....

20060276625 - Compositions and methods for fusion protein separation: The present invention relates to compositions and methods for fusion protein separation utilizing a peptide linker comprising a novel thrombin cleavage site....

20060276626 - Methods for the production of peptide derivatives: The invention relates to methods for the preparation of peptides which are a C-terminal amide derivatives by a combination of solid-phase synthesis and post assembly solution phase synthesis. The peptides which are a C-terminal amide derivatives are further converted to peptide acetates. The invention also relates to pure peptide acetates...

20060276627 - Angiotensin-converting enzyme inhibitory peptides: It is intended to provide ACE inhibitory tripeptides which are not easily digested by digestive enzymes after being orally taken and thus have fewer tendencies to lose their ACE inhibitory activity in vivo. More specifically, 3 tripeptides having an ACE inhibitory activity and showing a hypotensive effect in an animal...

20060276628 - Pharmaceutical formulations and ligands for use therein; mimetics for uea-1: UEA-1 Mimetics, pharmaceutical formulations comprising them, and their uses as targeting agents for therapeutic and diagnostic purposes....

20060276631 - Antibody against a mast cell surface antigen: A mast cell surface antigen, DNA thereof and an antibody against the antigen are provided. The amino acid sequence of this mast cell surface antigen is the translation of the coding region of its DNA. The base sequence of this DNA has been clarified in the following manner. Namely, mast...

20060276630 - Method for detecting protein crystal, apparatus for detecting protein crystal and program for detecting protein crystal: It is an object of the present invention to provide a protein crystal detection method, protein crystal detection apparatus, and protein crystal detection program with which protein crystals can be efficiently detected at a high reliability. To detect protein crystals with the present invention, an observed image obtained by observing...

20060276629 - Purification and characterization of soluble human hla proteins: The present invention relates generally to the production and use of functionally active soluble HLA molecules that are isolated and purified substantially away from other proteins, and methods of purifying same....

20060276632 - Acid soluble proteins from micellar casein: The present invention relates to a milk fraction obtainable by acidification of micellar casein and separation from precipitated casein named acid soluble protein from micellar casein. It was found that the milk fraction and especially certain sub-fractions thereof are bioactive and promote GLP-1 release in vitro. Based on these results,...

20060276633 - Method for the mass production of immunoglobulin constant region: Disclosed are a recombinant expression vector comprising a nucleotide sequence encoding an E. coli-derived signal sequence and a nucleotide sequence encoding an immunoglobulin constant region, and a transformant transformed with the expression vector. Also, disclosed is a method of mass-producing an immunoglobulin constant region by culturing the transformant and expressing...

20060276634 - Peg-conjugated erythropoietin: The present invention provides a polyethylene glycol-conjugated erythropoietin (PEG-conjugated EPO) prepared by PEG conjugation on the lysine residue at position 52 of native erythropoietin (native EPO). In order to achieve more sustained efficacy without losing physiological activities of native EPO, a glycoprotein rich in sugar chains, there has been a...