Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 08/06

20060194947 - Peptide gap junction modulators: Disclosed are dipeptides that facilitate the intercellular communication mediated by gap junctions. The invention has a wide spectrum of useful applications including use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC)....

20060194948 - Chemical processes by the use of combinations of solvents capable of taking reversibly homogeneously mixed state and separated state dependently on temperature: (Purpose) Providing a solvent set preferable for use as miscible-multiphase organic solvent system. While the miscible temperature of a solvent system is dropped by using a mixture solvent of plural solvents in the related art, the temperature can be dropped by a single solvent. Providing a solvent set appropriate for...

20060194950 - Mutant protein: The present invention relates to an immunoglobulin-binding protein, wherein at least one asparagine residue has been mutated to an amino acid other than glutamine or aspartic acid, which mutation confers an increased chemical stability at pH-values of up to about 13-14 compared to the parental molecule. The protein can for...

20060194949 - Structure of the farnesoid x receptor ligand binding domain and methods of use therefor: The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed with a ligand therefor. There are provided high resolution structures of FXR complexed with a novel high affinity agonist, fexaramine. The...

20060194952 - Enhancing the circulating half-life of antibody-based fusion proteins: Disclosed are methods for the genetic construction and expression of antibody-based fusion proteins with enhanced circulating half-lives. The fusion proteins of the present invention lack the ability to bind to immunoglobulin Fc receptors, either as a consequence of the antibody isotype used for fusion protein construction, or through directed mutagenesis...

20060194951 - Polynucleotides encoding interferon gamma polypeptides: A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence that differs from that of a parent IFNG polypeptide in at least one introduced and/or at least one removed amino acid residue comprising...

20060194953 - Antibody purification by protein a and ion exchange chromatography: A novel method for selectively removing leaked protein A from antibody purified by means of protein A affinity chromatography is disclosed....

20060194954 - Polypeptide variants: A variant of a polypeptide comprising a human IgG Fc region is described, which variant comprises an amino acid substitution at one or more of amino acid positions 270, 322, 326, 327, 329, 331, 333 or 334 of the human IgG Fc region. Such variants display altered effector function. For...

20060194955 - Protein ligands: The present invention relates to the use of an alkali-stable protein, wherein at least one asparagine residue has been mutated to an amino acid other than glutamine or aspartic acid, which mutation confers an increased chemical stability at pH-values of up to about 13-14 compared to the parental molecule. The...

20060194956 - Method for generating antibodies: Methods for generating antibodies in rodents are disclosed. The antibodies are useful as therapeutic agents, diagnostic agents or research reagents....

20060194957 - Polypeptide variants with altered effector function: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof....

20060189792 - Neisseria meningitidis antigenic polypeptides, corresponding polynucleotides and protective antibodies: The invention provides (Neisseria meningitidis) BASB030 polypeptides and polynucleotides encoding BASB030 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are antibodies, diagnostic, prophylactic and therapeutic uses thereof....

20060189791 - Recombinant expression of streptococcus pyogenes cysteine protease and immunogenic compositions thereof: The present invention generally relates to the fields of molecular biology, clinical bacteriology and protein folding. More particularly, the invention relates to methods for recombinantly expressing a soluble mature Streptococcus pyogenesexotoxin B (SpeB) polypeptide in a host cell....

20060189790 - Removal of lipopolysaccharides from protein-lipopolysaccharide complexes by non flammable solvents.: During the production of recombinant proteins from gram negative bacteria, lipopolysaccharides (LPS, endotoxin) are released along with the protein of interest. In many instances, LPS will copurify with the target protein due to specific or non-specific protein-ILPS interactions. We have investigated the ability of alkanediols to effect the separation of...

20060189794 - Ligand having agonistic activity to mutated receptor: The present inventors used antibody engineering techniques to prepare functional antibodies that correspond to individual mutations in causative genes of diseases, and discovered that such antibodies enable the treatment of the diseases. Specifically, the inventors succeeded in preparing ligands, particularly minibodies, which have agonistic activity to receptors that have almost...

20060189793 - Methods and compositions for inhibiting neoplastic cell growth: The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptdes. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for...

20060189797 - Magnetic polymer particles: A conjugate comprising a magnetic polymer particle bound to a carboxymethylated aspartate chelating ligand, optionally chelating a metal ion....

20060189796 - Separating agent for enantiomeric isomers: The present invention provides a separating agent for enantiomeric isomers which exhibits high optical resolving power together with solvent resistance. That is, the present invention provides a separating agent for enantiomeric isomers including a polysaccharide derivative such as a carbamate derivative or ester derivative of cellulose or amylose carried on...

20060189795 - Use of ph-responsive polymers: The present invention relates to a method of isolating target compounds from a liquid, which comprises at a first pH, contacting the liquid with a separation medium that exhibits surface-localised pH-responsive polymers in to adsorb the target compound via hydrophobic interactions; and adding an eluent, which is of a second...

20060183883 - C5a receptor antagonists: The invention relates to a C5a receptor antagonist of structure (I), wherein X1 is a radical having a mass of about 1-300 and stands for R5-, R5-CO—, R5-N(R6)-CO—, R5-O—CO—, R5-SO2—, R5-N(R6)-SO2—, R5-N(R6)-, R5-N(R6)-CS—, R5-N(R6)-C(NH)—, R5-CS—, R5-P(O)OH—, R5-B(OH)—or R5-CH═N—O—CH2—CO—, wherein R5/R6 represent H, F, hydroxy, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl,...

20060183884 - Compounds and methods for modulating cell adhesion: Cyclic peptides comprising a cadherin cell adhesion recognition sequence HAV, and compositions comprising such cyclic peptides, are provided. Methods for using such peptides for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided....

20060183886 - Ligands to enhance cellular uptake of biomolecules: The present invention relates to the design and synthesis of homogeneous A-L-P constructs, which contain a hepatic ligand to direct an oligomer or “payload” to a hepatocyte intracellularly via a receptor-mediated, ligand-directed pathway....

20060183885 - Protein forming complex with c-fos protein, nucleic acid encoding the same and method of using the same: Proteins that interact with c-Fos, nucleic acids encoding them and inhibitors utilizing them as well as methods for detecting an interaction and screening methods utilizing a protein that interacts with c-Fos are provided. Comprehensive analysis of transcription control factor complexes in a mouse brain cDNA library with c-Fos as a...

20060183887 - Human monoclonal antibodies to epidermal growth factor receptor: In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided....

20060183888 - Pyrrolysine synthesis and modification:

20060183889 - Alkyl phosphine detergent products and extraction processes: Provided herein are compositions and kits comprising alkylphosphine oxide detergents, and methods for the use thereof for the extraction of component molecules from cells. These compositions, kits and methods can provide efficient extraction of cellular components in a mild environment. While applicable to cell-associated molecules generally, the methods and compositions...

20060173159 - Water-soluble thioester and selenoester compounds and methods for making and using the same: Water-soluble thioester and selenoester compounds, their generators, as well as methods for making and using the same, are provided. The subject thioester and selenoester compounds are characterized by including an amino acid synthon having a C-terminal group bonded to a water-soluble polymer through a thioester or selenoester linkage. Solid phase...

20060173160 - Synthesis and characterization of novel systems for guidance and vectorization of molecules of therapeutic interest towards target cells: A method for preparing a grafted homodetic cyclopeptide froming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or unmodified amino acids, some of which carry orthogonal protective groups; intramolecular cyclizing the resulting protected linear peptide; substituting some or all...

20060173161 - Protein-binding doxorubicin peptide derivatives: The invention relates to low-molecular doxorubicin peptide derivatives containing MMP-2 or MMP-9 divisible peptide sequences and a protein-binding group....

20060173162 - Bactericidak anti-apoptotic, pro-inflammatory and anti-inflammatory peptides of heparin-binding protein (hbp): The present invention relates to providing new peptide fragments derived from the sequence of heparin-binding protein (HBP) and/or human neutrophil elastase and using said fragments for the manufacture of a medicament for the treatment of Gram positive and/or Gram negative infections. Thus, the peptides of the inventions can be used...

20060173163 - Synthesis using peptide intermediate fragments: Methods for the solid phase synthesis of T-1249 peptides and peptide intermediates, in particular methods involving synthesizing T-1249 peptide intermediates at low loading factors to produce products having excellent purity and yield....

20060173166 - Protein lattice: Protein lattice (1) having a regular structure with a repeating unit repeating in three dimensions may have many uses, for example to support an array of macromolecular entities for x-ray crystallography. The repeating unit comprises protein protomers (2) which each comprise at least two monomers (5, 6) fused together. The...

20060173164 - Staphylococcal nuclease fusion proteins for the produciton of recombinant peptides: Peptides are produced as fusions with a suitable carrier protein. The carrier protein disclosed herein are adapted from the N-terminal domain of staphylococcus nuclease. This novel carrier protein acts to promote the over-expression of the peptide-protein fusion in the form of inclusion bodies, which minimizes in-cell proteolysis of desired peptides....

20060173165 - Systems for expressing toxic proteins, vectors and method of method of producing toxic proteins: The present invention relates to a system for expressing toxic proteins, to an expression vector comprising this system, to a prokaryotic cell transformed with this system, and also to a method for synthesizing a toxic protein using this expression system. The expression system of the invention is characterized in that...

20060173167 - Process for the purification of recombinant polypeptides: This invention relates to a method for purification of a recombinant polypeptide of interest, which polypeptide upon expression has been secreted into the periplasm of a transformed host cell....

20060173168 - Bioactive peptides and unique ires elements from myelin proteolipid protein plp/dm20: Three novel low molecular weight (LMW) polypeptide fragments of a proteolipid protein human PLP/DM20 are designated PIRP-M, PIRP-L and PIRP-J, and are growth factors for oligodendrocytes with anti-apoptotic activity. They are encoded by mRNA from an IRES. Fusion polypeptides of such a LMW polypeptide, DNA encoding the LMW polypeptide and...

20060173169 - Method and system for corn fractionation: Methods and apparatus for processing corn into one or more corn products. Oil is extracted from corn or corn products or by-products with a solvent. The corn-solvent mixture is separated into streams, one of which preferably includes an extract containing at least oil and solvent, and another containing de-oiled corn...

20060173170 - Fc variants with altered binding to fcrn: The present application relates to optimized IgG immunoglobulin engineering methods for their generation, and their application, particularly for therapeutic purposes....

20060173171 - Techniques and compositions for diagnosis and treatment of cancer (muci): The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1 cell proliferation are discussed....