Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 07/06

20060167220 - Methods and compositions for preparing peptides with excellent solubility characteristics in aqueous solution at physiological ph: The formation of inactive, insoluble forms of peptide can be minimized or, alternatively, inactive, insoluble forms of peptide compounds, if present, can be converted into more physiologically active, soluble forms by dissolving peptide samples in aqueous base and then acidifying the aqueous mixture to precipitate the peptide in the presence...

20060167221 - Process for the extraction and isolation of insulin from recombinant sources: The present invention relates to the extraction and isolation of insulins from recombinant sources, particularly those expressed in and secreted by yeasts. Organic solvents have been used to extract host surface bound forms of insulin polypeptide. In addition, procedures for combining the steps medium clarification, solvent extraction and chromatography, in...

20060167222 - sh2 domain binding inhibitors: Disclosed are compounds for SH2 domain binding inhibition, for example, a compound of formula (I), wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is hydrogen, azido, amino, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, or alkylcarbonylamino, wherein the...

20060167223 - Novel ampiphilic fluorocarbon molecular vectors for biomedical and medical use: Novel ampiphilic fluorocarbon molecules applicable as vectors for active ingredients, active molecules comprising such a vector and the use thereof in the pharmaceutical field, particularly for the production of medicaments....

20060167224 - Novel functional peptide nucleic acid and process for producing the same: A functional molecule can be introduced extremely rapidly and with superior cost performance by using a method for producing a functional PNA oligomer that comprises synthesizing a PNA oligomer by reacting a PNA monomer unit having a protected adenine, guanine, cytosine or thymine with Boc-lysine(Fmoc)-OH or Fmoc-lysine(Alloc)-OH, followed by introducing...

20060167229 - Biologically active peptide conjugates: Thirty substantially pure and biologically active peptides are disclosed. Nucleic acids that have sequences coding for the biologically active peptides and pharmaceutical formulations produced therefrom are also disclosed. Methods for altering the biological activity of the peptides are disclosed....

20060167226 - Mutations of voltage-gated ion channnels that allow them to express a voltage-independent phenotype and an improved method to use the same: The subject invention includes mutant voltage-gated ion channels that are open over a wide range of potential differences across membranes. The present invention also includes methods of use such mutant voltage-gated ion channels in cells with highly negative potential differences across their membranes. One preferred mutant voltage-gated ion channel is...

20060167225 - Novel fluorescent protein from aequorea coerulscens and methods for using the same: The present invention provides nucleic acid compositions encoding a novel colorless GFP-like protein, acGFP, from Aequorea coerulscens and fluorescent and non-fluorescent mutants and derivatives thereof, as well as peptides and proteins encoded by these nucleic acid compositions. The subject protein and nucleic acid compositions of the present invention are colored...

20060167228 - Sequences from an endosymbiont and their uses: rDNA corresponding to an endosymbiotic bacteria associated with Ecteinascidia turbinata has been identified. The bacterium appears to be responsible for the biosynthesis of ecteinascidin compounds. The 16S rDNA sequence corresponding to Candidatus Endoecteinascidia frumentensis SEQ ID NO: 1 has been deposited in GeneBank with the accession number AY054370....

20060167227 - Truncated tau proteins: Described are novel N- and C-terminally double truncated tau molecules, (“type IA, IB, IIA and IIB tau molecules”) as well as methods for providing these molecules, both from recombinant and biological sources. Moreover, screening methods using these molecules in connection with Alzheimer's diagnosis and therapy are provided....

20060167230 - Anti-pci neutralizing antibody: The present invention provides anti-PCI antibodies having Protein C inhibitor (PCI)-neutralizing activity, and the uses thereof. Through the generation and screening of anti-PCI antibodies, the inventors successfully isolated anti-PCI antibodies which inhibit PCI's inhibitory effect on the production and activity of activated Protein C (aPC). The antibodies of the present...

20060167231 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060167232 - Antibody against n-terminal peptide or c-terminal peptide of gpc3 solubilized in blood: Disclosed is an antibody against a secreted form of GPC3 capable of detecting a secreted form of glypican 3 (GPC3) in a test sample. It is possible to determine whether a subject suffers from cancer, in particular hepatoma. Also disclosed is an antibody against GPC as well as a cell...

20060167233 - One-step reduction and alkylation of proteins: The present invention relates generally to the field of analyzing proteins and more specifically to the reduction and alkylation of protein samples during protein analysis. A novel composition and method for reducing and alkylating proteins is disclosed. A novel reagent including a combination of a volatile reducing agent, a volatile...

20060167234 - Aryl carbamate oligomers for hydroilyzable prodrugs and prodrugs comprising same: where X is alky1-6 or is not present, Y is N or O or is not present, and R3 is alkyl1-6; PAG is a linear or branched polyalkylene glycol moiety; R2 is an alkyl1-22 capping moiety if X is present or alkyl2-22 if X is not present; and q is...

20060160989 - Polypeptide useful as antiallergic/antiasthmatic activity, methods for the preparation thereof, pharmaceutical compositions containing such polypeptide and use thereof: This present invention relates to new peptides L-N-substituted-alanyl-N-substituted-glycyl-N-substituted-glycyl-L-aspartyl-N-substituted-glycyl-L-lysyl (SEQ ID NO: 1, where R1—R4 of formula 1 are H and R5 of formula 1 is OH) derivatives which can be used as therapeutic agents for allergy/asthma and a process for preparing the said compounds and its formulation for administration by...

20060160990 - Fluorescent protein and chromoprotein: It is an object of the present invention to provide a novel chromoprotein and a novel fluorescent protein. The present invention provides chromoproteins derived from Anthopleura inornata, which have certain property, and fluorescent proteins from Trachyphyllia geoffroyi and Scolymia vitiensis, which have certain fluorescent property....

20060160991 - Genes and polypeptides relating to prostate cancers: The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes...

20060160992 - Method of identifying cells expressing a protein having pre-b cell growth-supporting ability: A gene encoding a novel membrane protein polypeptide having pre-B cell growth-supporting ability, and a novel membrane protein polypeptide consisting of 180 amino acid residues having pre-B cell growth-supporting ability or a part of it. A method for producing said novel membrane protein polypeptide by preparing transformants by transforming a...

20060160993 - Compositions and methods for regulating rna stability using polypyrimidine tract proteins: Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of polypyrimidine tract proteins with the 3′-untranslated region of CD154....

20060160994 - Factor viii polypeptide having factor viii:c activity: Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same....

20060160996 - Optimized fc variants and methods for their generation: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants....

20060160995 - Thrombopoietin proteins with improved properties: The invention concerns human thrombopoietin and in particular modified forms of thrombopoietin (TPO) with improved properties. The improved proteins contain amino acid substitutions at specific positions within the TPO molecule. The invention provides modified TPO molecules, preferably fusion proteins comprising immunoglobulin constant regions and modified human TPO, with improved biological...

20060160997 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same....

20060160998 - Methods for isolation and purification of fluorochrome-antibody conjugates: The invention provides methods for isolating a fluorochrome-antibody conjugate from an aqueous mixture of the conjugate and unconjugated fluorochrome. The method involves contacting the mixture with a water insoluble stationary phase having a metal ion chelated thereto and binding the conjugate to the stationary phase. The phase containing bound conjugate...

20060155107 - Sstr1-selective analogs: Analogs of SRIF which are selective for SSTR1 in contrast to the other cloned SRIF receptors. These analogs are useful in determining the tissue and cellular expression of the receptor SSTR1 and its biological role in the endocrine, exocrine and nervous system, as well as in regulating tumor growth. SRIF...

20060155108 - Multiple branch peptide construction: Multiple branch peptide constructions formed from peptide-branches derived from the envelope transmembrane glycoprotein gp41 of HIV, and including the consensus sequence RQGY preceded by 0 to 4 amino acid residues and succeeded by 0 to 4 amino acid residues, most preferably RQGYS, show increased receptor affinity and prevent cell-to-cell fusion....

20060155109 - Novel physiologically active peptide and its use: The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an...

20060155110 - Process for the manufacture of disubstituted amines: e

20060155112 - Fibrr-shaping peptides capable of interacting with self-assembling peptides: The present invention relates to a fibre-shaping peptides that are capable of interacting with self-assembling peptides to form protein structures. The present invention also relates to methods of forming protein structures using the fibre-shaping peptides of the present invention....

20060155115 - Multivalent t cell receptor complexes: The present invention relates to a synthetic multivalent T cell receptor complex for binding to a MHC-peptide complex, which multivalent T cell receptor complex comprises a plurality of T cell receptors specific for the MHC-peptide complex. It is preferred that the T cell receptors are refolded recombinant soluble T cell...

20060155111 - Novel genes and their use in the modulation of obesity, diabetes and energy imbalance: The present invention relates generally to nucleic acid molecules encoding proteins associated with the modulation of obesity, diabetes and/or metabolic energy levels. More particularly, the present invention is directed to nucleic acid molecules and the recombinant and purified proteins encoded thereby and their use in therapeutic and diagnostic protocols for...

20060155114 - Protein complex, process for producing the same and use thereof: It is intended to provide a protein complex and a production process whereby the protein complex can be efficiently produced without lowering its function. It is also intended to provide use of the protein complex in a biosensor, an immobilized enzyme and so on. A protein complex comprising a polyhedral...

20060155113 - Replication protein: This invention relates to a screening method for the identification of agents which modulate the activity of a DNA replication protein as a target for intervention in cancer therapy and includes agents which modulate said activity. The invention also relates to the use of the DNA replication protein, and its...

20060155116 - Hypoallergenic variants of the parietaria judaica major allergens, uses thereof and compostitions comprising them: A multimer protein molecule comprising at least a first amino acid sequence having substantially the sequence of one of the Parietaria judaica major allergens and a second amino acid sequence having substantially the sequence of one of the Parietaria judaica major allergens Par j 1 or Par j 2, and...

20060155117 - Novel preadipocyte factor-1-like polypeptides: The present invention discloses open reading frames (ORFs) in human genome encoding for novel Preadipocyte factor-1-like polypeptides, and reagents related thereto including variants, mutants and fragments of said polypeptides, as well as ligands and antagonists directed against them. The invention provides methods for identifying and making these molecules, for preparing...

20060155118 - Affinity purification system using troponin molecules as affinity ligands: This invention pertains to the use of a novel set of tags for the immobilization and/or purification of proteins or other biological or organic molecules. The invention provides troponin C, troponin C binding peptide, and troponin I, or active fragments or analogues thereof as convenient tags and affinity ligands for...

20060149032 - Recombinant hepatitis b surface antigen: The present invention provides an improved rHBsAg that exhibits a higher antigenicity and immunogenicity than that previously known in the art. A method of making the improved rHBsAg is also provided. The improved HBsAg is used to provide vaccines with lower amounts of active ingredient, vaccines with higher immunogenicity and...

20060149033 - Igf antagonist peptides: Peptides are provided that antagonize the interaction of IGF-1 with its binding proteins, insulin receptor, and IGF receptor. These IGF antagonist peptides are useful in treating disorders involving IGF-1 as a causative agent, such as, for example, various cancers....

20060149034 - Homing peptides to receptors of heart vasculature: The present invention relates to peptides which selectively or preferentially home to areas of a heart. The invention further relates to conjugates of the homing peptides and uses thereof....

20060149035 - Method for the synthesis and selective biocatalytic modification of peptides, peptide mimetics and proteins: The present invention relates to a method for the synthesis of peptides, peptide mimetics and/or proteins and/or for the selective N-terminal modification of peptides, peptide mimetics and/or proteins, with the steps of: a) providing an amino component, said amino component having at least one amino acid, b) providing a carboxyl...

20060149036 - Composition and method for self-assembly and mineralizatin of peptide amphiphiles: The present invention is directed to a composition useful for making homogeneously mineralized self assembled peptide-amphiphile nanofibers and nanofiber gels. The composition is generally a solution comprised of a positively or negatively charged peptide-amphiphile and a like signed ion from the mineral. Mixing this solution with a second solution containing...

20060149037 - Cupredoxin derived transport agents and methods of use thereof: The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer....

20060149038 - Pro211 polypeptides: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060149039 - Pseudo-native chemical ligation: The present invention concerns methods and compositions for extending the technique of native chemical ligation to permit the ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond. The invention further provides methods and uses for such proteins and derivatized proteins. The invention...

20060149040 - Collagen and method for producing same: The present invention relates to a method for producing collagen from an animal skin. In particular, the present invention a method for producing collagen from an animal skin comprising the step of applying to said skin an organic acid buffer for sufficient time to enable the extraction of collagen....

20060149041 - Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation: The present invention relates to polypeptides comprising at least one single domain antibody directed against vWF, vWF A1 domain, A1 domain of activated vWF, vWF A3 domain, gpIb and/or collagen, homologues of said polypeptides, and/or functional portions of said polypeptides, for the treatment for conditions which require a modulation of...

20060149042 - Process for concentration of macromolecules: The invention provides methods for concentrating a macromolecule from a solution comprising the macromolecule and an organic polymer by first subjecting the solution to ultrafiltration to produce a first retentate solution, then adjusting the conductivity of the first retentate solution such that any protein precipitation induced by the organic polymer...