Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof inventions 03/06

20060069238 - Synthetic glyco-lipo-peptides as vaccines: A glycolipopeptide comprising at least one disease-associated epitope, and characterized by at least one lipidated interior amino acid or by the presence of a MUC1 epitope, may be used in a vaccine, preferably in conjunction with a liposome....

20060069241 - Endocytosing delivery vehicle for targeting drugs and antibodies to prostate and other tissues: A chimeric transmembrane protein comprising a membrane-spanning polypeptide and an internalization motif of the sequence MXXXL, where X is any amino acid. The chimeric protein can be expressed on the surface of a cell and internalized. Polynucleotides and expression vectors encoding chimeric transmembrane proteins are also provided. Expression of chimeric...

20060069239 - Epididymis-specific gene as potential contraceptive target: Isolated splice variant polypeptides from the family of human epididymis-specific receptors called HE6, and related polypeptides from mouse (ME6) and rat (RE6), are described. Also described are isolated polynucleotides encoding the polypeptides, and fragments and variants of the polypeptides and polynucleotides. The polypeptides are involved in maturation of sperm during...

20060069240 - Identification and characterization of reflectin proteins from squid reflective tissues: A family of reflectin proteins is identified herein that is deposited in flat, structural platelets in reflective tissues of the squid Euprymna scolopes. These proteins are encoded by at least six genes in three subfamilies and have no reported homologues outside of squids. Reflectins possess 5 repeating domains, that are...

20060069242 - Neurotrophic factor receptor: There is disclosed a novel mammalian receptor protein designated GFRα-4 and the nucleic acid sequence encoding therefore; an isolated and purified GFR α-4 receptor polypeptide comprising SEQ ID NO: 9. Also provided is an expression vector comprising the nucleic acid sequence and host cells transformed or transfected with the vector....

20060069243 - Ovary-specific genes and proteins: Ovary specific proteins O1 180, O1 184 and O1 236, polynucleotides encoding them, antibodies which are immunoreactive with them and vectors and host cells containing O1 180, O1 184 or O1 236 are provided. Also provided are methods for detecting cell proliferative or degenerative disorders of ovarian origin and which...

20060069244 - Method and system for solubilizing protein: A process for solubilization of protein including application of an alkali, such as lime, and heating. The process may also involve lime recovery and may be accomplished in a single stage or two stages to separate protein solubilized from labile and recalcitrant sources. Systems and devices for use in such...

20060058502 - Superabsorbent polymer product and use in agriculture: A superabsorbent starch graft copolymer product having particle sizes useful in granule applicators for application to agricultural fields. Starch graft copolymers applied to field crops provide excellent anti-crusting properties, increased seed germination and stand, increased crop growth, increased yields, and reduced water requirements....

20060058503 - Process for preparing glycopeptide derivatives: Disclosed are processes for preparing glycopeptide antibiotic derivatives having an amino-containing side chain. The multi-step process is conducted in a single reaction vessel without isolation of intermediate reaction products....

20060058504 - Peptides capable of inducing attraction to the axonal growth and their use for treating neurodegenerative diseases: The present invention is directed to peptides comprising the sequence ASNKL (SEQ ID No. 1), inducing attraction of the axonal growth in presence of the semaphorin (Sema3A), L1 and NP-1 proteins and their use for the manufacture of a drug for neuronal/axonal regeneration or for treating neurodegenerative diseases. The present...

20060058510 - Anticalins: The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus...

20060058507 - Krib polynucleotides and polypeptides and uses thereof in the treatment of metabolic disorders: The present invention relates to the field of metabolic research. KRIB polypeptides have been identified that are beneficial in the treatment of metabolic disorders. These compounds should be effective for reducing body mass and for treating metabolic disorders. These metabolic disorders include hyperlipidemia, atherosclerosis, diabetes, and hypertension....

20060058508 - Novel functional peptide nucleic acid and process for producing the same: e

20060058505 - Nucleic acid and polypeptide linked to breast cancer and uses therefor: The present invention relates to an isolated domain of G3BP-2 that mediates binding between G3BP-2 and other proteins, and nucleic acids encoding same. The invention also relates to a method for diagnosing, treating and preventing breast cancer including the step of using a nucleic acid and/or encoded polypeptide for G3BP-2,...

20060058509 - Refolding of membrane proteins: In a method for production of membrane receptors folded into their native structure, first, receptors solubilized in a first detergent are provided. To induce folding of receptors into their native form, the first detergent is exchanged for a second detergent. Both for the first and for the second detergent, examples...

20060058506 - Synthetic anti-candida albicans oligosaccharide based vaccines: The present invention provides methods of making and using immunogenic oligosaccharide compositions comprising native O-linked and S-linked oligosaccharides coupled to a protein carrier, wherein the resultant conjugate elicits a protectively immunogenic response. These compositions may be useful in vaccines against pathogenic Candida species....

20060058511 - Method for stabilizing protein solution preparation: Problems to be Solved: The present invention provides a method for improving the stability of protein solution formulations by suppressing the formation of associated matter from physiologically active proteins (e.g., antibodies, enzymes, hormones, cytokines) in a solution form. Means for Solving the Problems: A method for stabilizing a protein solution...

20060058512 - Process for producing humanized chimera antibody: A humanized chimera antibody, a pharmaceutical composition comprising a humanized chimera antibody and a pharmaceutically acceptable carrier, and a method of treating cancer which comprises administering to a patient a pharmaceutically acceptable amount of the humanized chimera antibody, are disclosed....

20060058513 - Oxime conjugates and methods for their formation and use: The present invention relates to biodegradable biocompatible polyketals, methods for their preparation, and methods for creating animals by administration of biodegradable biocompatible polyketals. In one aspect, a method for forming the biodegradable biocompatible polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is...

20060052580 - Chimeric proteins for diagnosis and treatment of diabetes: Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins of the invention are useful in predicting risk of onset of...

20060052581 - Chimeric proteins for diagnosis and treatment of diabetes: Novel chimeric fusion proteins comprising immunodominant epitopes of GAD and insulin are provided. Also provided are immunomodulatory methods for the use of such proteins for both the prevention and treatment of Type 1 diabetes mellitus. The chimeric fusion proteins of the invention are useful in predicting risk of onset of...

20060052582 - Identification of inhibitors of mitosis: Methods and compositions are described for using NIMA-like kinases to identify anti-mitotic compounds and to diagnose cancer....

20060052584 - Human-derived bradeion proteins, dna coding for the proteins, and uses thereof: A human-derived bradeion protein, which has the following properties: (i) it is a transmembranous protein; (ii) it has a structure characteristic of growth hormone and cytokine receptors even in a structure of its transmembranous portion when its structure is determined by a hydrophobicity analysis according to Kyte-Doolittle method; (iii) it...

20060052583 - Protein production: Proteins may be made by genetically engineered microorganisms, the protein being stored in the form of inclusion bodies (IB). The proteins in the inclusion bodies are in an insoluble and inactive form. They may be dissolved using a solubilisation reagent (18), and the resulting solution diluted so that the proteins...

20060052585 - Method for the generation of genetically modified vertebrate precursor lymphocytes and use thereof for the production of heterologous binding proteins: The present invention generally relates to the fields of genetic engineering and antibody production. In particular, it relates to the generation of genetically modified vertebrate precursor lymphocytes that have the potential to differentiate into more mature lymphoid lineage cells, and to the use thereof for the production of any heterologous...

20060052586 - Process for preparation of mixtures of polypeptides using purified hydrobromic acid: The subject invention provides an improved process for obtaining a mixture of polypeptides having nonuniform amino acid sequences, where each polypeptide consists essentially of alanine, glutamic acid, tyrosine and lysine where the resulting mixture of polypeptides comprises less than 0.3% brominated tyrosine and less than 1000 ppm metal ion impurities....

20060047105 - Polymer-supported reagent for the preparation of disulfide-bridged peptides: P

20060047106 - Neisseria meningitdis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof: The present invention is directed to novel Neisseria meningitidis lipo-oligosaccharide inner core molecules, conjugates thereof and immunogenic compositions thereof. In particular embodiments, the invention relates to multivalent immunogenic compositions comprising five distinct Neisseria meningitidis inner core lipo-oligosaccharide epitope groups, wherein the multivalent compositions induce cross-reactive immune responses against Neisseria meningitidis...

20060047107 - Cortistatin: neuropeptides, compositions and methods: The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof....