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Chemistry: molecular biology and microbiology

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
10/02/2014 > 157 patent applications in 72 patent subcategories.

20140295402 - Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations: This document provides methods and materials for enhancing the storage capabilities of red blood cell preparations. For example, methods and materials for using CO2 to store red blood cells in a manner that (a) reduces the level of glucose or 2,3-DPG consumption of or reduces the level of 2,3-DPG production... Agent:

20140295407 - Biosensor based on the innate immune system: Described herein are biosensors for early, pre-symptomatic detection of infectious agents and methods for their use. In particular, this disclosure describes biosensors that utilize toll-like receptor (TLR) binding domains to detect pathogen-associated molecular patterns (PAMPs). Also provided herein are methods of detecting and/or capturing a PAMP from a biological sample... Agent: Los Alamos National Security, LLC

20140295405 - Chromatography method, and chromatography kit: The chromatography method of the present invention includes (a) developing a complex of a test substance and a labeling substance modified with a first binding substance bindable to the test substance, onto an insoluble carrier, (b) causing the complex to be trapped in a reaction site on the insoluble carrier... Agent: Fujifilm Corporation

20140295408 - Compositions, methods, and kits for nucleic acid hybridization: Polynucleotides having a first polynucleotide segment contiguous with a second polynucleotide segment that is downstream to the first, wherein the sequence of the first polynucleotide segment is complementary to the sequence of a first probe segment of a probe for detection of a target nucleic acid sequence, wherein the sequence... Agent: Grifols Therapeutics Inc.

20140295403 - Detection of biological molecules by differential partitioning of enzyme substrates and products: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of... Agent: Queen's University At Kingston

20140295409 - Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences: The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a... Agent:

20140295406 - Portable device for detection of harmful substances: A self-contained apparatus and methods for detecting the presence of any specified substance in any medium. A sample of the medium is placed in a capsule, along with a solvent and a sensor configured to test for a target analyte. The solvent comes into contact with the medium in the... Agent: 6sensorlabs, Inc.

20140295404 - Sample fixation and stabilisation: It has surprisingly been discovered that it is possible to stabilise biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology... Agent:

20140295410 - Conjugate of a metal nanoparticle and a light emitting material: Disclosed are a conjugate of a metal nanoparticle including a magnetic core and at least one light emitting material linked to the metal nanoparticle through a linker, wherein the linker has an affinity for a biological material and has changed structure after contacting a biological material, a biosensor including the... Agent:

20140295415 - Low cost, disposable molecular diagnostic devices: The invention provides molecular diagnostic test devices and methods for using such diagnostic test devices to detect analytes of biological significance in a patient. The diagnostic test devices are particularly useful for detecting a polynucleotide analyte in a sample obtained from a patient. Further, the diagnostic test devices are inexpensive,... Agent: Diagnostics For All, Inc.

20140295414 - Methods and compositions for labeling nucleic acids: The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. In particular, the methods include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Such methods do not require fixation and... Agent:

20140295411 - Methods and reagents for preserving rna in cell and tissue samples: This specification relates to the field of molecular biology and provides novel methods and reagents for preserving and protecting the ribonucleic acid (RNA) content of samples from degradation prior to RNA isolation. This preservation may be accomplished without ultra-low temperature storage or disruption of the tissue.... Agent: Applied Biosystems, LLC

20140295412 - Methods and systems for direct sequencing of single dna molecules: The invention provides improved methods for sequencing nucleic acids, e.g., for medical applications and biomedical research. The disclosed methods can be applied to rapid personalized medicine, genetic diagnosis, pathogen identification, and sequencing species genomes.... Agent: The Regents Of The University Of California

20140295413 - Systems, methods, and workflows for optogenetics analysis: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and... Agent:

20140295429 - Biosample storage devices and methods of use thereof: The present invention provides sample collection, shipping, and storage devices and methods of using the same. These devices and methods are useful, for example, for collecting, shipping, and storing biological samples, such as blood, serum, buccal samples, tissue homogenates, or cell lysates in a dry state. The devices and methods... Agent:

20140295425 - Diagnosis for alzheimer's disease: The present invention relates to diagnosis and monitoring of Alzheimer's disease in the live subject. More particularly, the invention relates to methods involving the measurement of differential gene expression in non-neuronal cells taken from human subjects suspected of having Alzheimer's disease wherein the genes to be measured are genes within... Agent: The University Of Birmingham

20140295421 - Enzyme quantification: The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting... Agent: Raindance Technologies, Inc.

20140295427 - Fibrosis susceptibility il22ra2 gene and uses thereof: The present invention discloses the identification of a fibrosis susceptibility gene locus, the IL22RA2 gene locus, which can be used for detecting predisposition to, diagnosis and prognosis of fibrosis as well as for the screening of therapeutically active drugs. The invention further provides a method for determining the likelyhood of... Agent: Universite D'aix-marseille

20140295417 - Identification of antibiotic resistance: The invention relates to a method and a kit for the detection of an antibiotic resistance in a predetermined micro-organism in a biological sample. The method according to the invention comprises the following steps: (a) contacting the biological sample with a first nucleic acid labelled with a first label and... Agent: Miacom

20140295424 - Isolation and enrichment of nucleic acids on microchip: Techniques for isolating, enriching, and/or amplifying target DNA molecules using MEMS-based microdevices are disclosed. The techniques can be used for detecting single nucleotide polymorphism, and for isolating and enriching desired DNA molecules, such as aptamers.... Agent: The Tustees Of Columbia University In The City Of New York

20140295430 - Method for analyzing biomolecules and biomolecule analyzer: The method for analyzing biomolecules, includes the steps of: immobilizing biomolecules to be analyzed on surfaces of magnetic microparticles; reacting labeled probe molecules with the biomolecules to be analyzed; collecting and immobilizing the microparticles on a support substrate; and measuring a label on the support substrate. Since single-molecule immobilized magnetic... Agent:

20140295428 - Method for high-throughput aflp-based polymorphism detection: The invention relates to a method for the high throughput discovery, detection and genotyping of one or more genetic markers in one or more samples, comprising the steps of restriction endonuclease digest of DNA, adaptor-ligation, optional pre-amplification, selective amplification, pooling of the amplified products, sequencing the libraries with sufficient redundancy,... Agent:

20140295431 - Method of allele-specific amplification: A method of selectively producing and amplifying a cDNA sequence of a target allele of a gene, wherein the target allele is a mutant allele or is a specific allele of a polymorphic gene, the method comprising: (a) providing a sample comprising an mRNA transcript of the target allele; (b)... Agent: Clarient Diagnostic Services, Inc.

20140295418 - Methods and compositions for improving removal of ribosomal rna from biological samples: The invention generally relates to compositions for maximizing capture of affinity-labeled molecules on solid supports. The disclosed methods and compositions were developed to maximize depletion of ribosomal RNA from total RNA samples, which is useful to improve the quality of RNA preparations used for applications such as massively parallel sequencing.... Agent: Bioo Scientific Corporation

20140295419 - Methods and compositions for isothermal whole genome amplification: Disclosed are methods and compositions for amplification of genetic material, including isothermal WGA of single cells.... Agent: Celula, Inc.

20140295426 - Methods for diagnosing cancer by characterization of tumor cells associated with pleural or serous fluids: A method for diagnosing or differentially diagnosing a cancer characterized by the presence of cancer cells in the pleural fluid of a mammalian subject, the method comprising contacting a sample of pleural fluid of the subject with colloidal magnetic particles coupled to a ligand which binds to a determinant on... Agent: The Trustees Of The University Of Pennsylvania

20140295423 - Methods for genetic analysis of textiles made of gossypium barbadense and gossypium hirsutum cotton: Methods for distinguishing between cotton species by analyzing a sample of mature cotton fibers from raw cotton materials or from textile goods are disclosed. DNA is extracted from the mature cotton fiber sample and subjected to PCR techniques which enable the identification of the species of cotton utilized in the... Agent: Apdn (b.v.i.) Inc.

20140295416 - Novel method of cancer diagnosis and prognosis and prediction of response to therapy: The invention relates to pharmaceutical compositions comprising of FRY polypeptides and nucleotides, methods to treat cancer, methods to diagnose cancer, and methods to determine the effectiveness of the treatment of cancer, as well as methods to differentiate stem cells.... Agent: University Of Medicine And Dentistry Of New Jersey

20140295432 - Particle repulsion to enhance surface contact in magnetic particle immunoassays: The present invention relates to a device for detecting a target molecule within a sample comprising a sample container for the measurement of the target molecule within a sample, a magnetic particle, wherein said particle is functionalized with a first binding molecule capable of specifically binding to said target molecule,... Agent: Koninklijke Philips N.v.

20140295420 - Processing of biological sample components: The invention relates to means for processing a sample fluid containing different components, particularly magnetic particles (M) and targets (cells) (C+M) labeled with magnetic particles. A processing device (100) according to the invention comprises a container (110) with a first compartment (120) that can be filled with a sample fluid... Agent:

20140295422 - Quantitative real-time pcr assay using fret dual-labeled primers: This specification relates to non-radioactive methods, compositions and kits for non-radioactive real-time PCR using FRET dual-labeled primers and do not require the use of a probe. The non-radioactive methods may also be used for end-point PCR in which the signal is measured only at the endpoint of the PCR cycling.... Agent: Life Technologies Corporation

20140295441 - Cartridge interface module: A cartridge interface module (CIM), configured to engage with a removable microfluidic cartridge in a nucleic acid analyzer system can include a fluidics component, which is configured to initiate and support a liquid extraction of nucleic acids from a biological sample contained in the removable microfluidic cartridge. The CIM also... Agent: Lockheed Martin Corporation

20140295437 - Cyanine compounds and their application as quenching compounds: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium, substituted quinolinium, unsubstituted quinolinium, substituted benzazolium, unsubstituted benzazolium, substituted indolinium, or substituted indolinium. The invention further provides luminescent donor molecule-quencher pairs and luminescent donor molecule-quencher-luminescent acceptor molecule conjugates wherein the quencher is a cyanine compound of the present invention. The... Agent: Life Technologies Corporation

20140295434 - Detection method of micro-rna with high specificity: The invention provides a method for detecting miRNA based on polymerase chain reaction comprising EvaGreen dye, and the use of EvaGreen dye in elevating the binding specificity of primers to templates in PCR.... Agent: Biovue Technology Ltd.

20140295444 - Diagnosis and treatment of breast cancer: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to compositions and methods for the prediction of a subject's response to cancer therapies.... Agent:

20140295438 - Method and components for detecting nucleic acid chains: The invention relates to a novel method for the enzymatic marking of nucleic acid chains (target sequences) by means of nucleotide conjugates. Said nucleotide conjugates are able, under reaction conditions, to specifically bind to the target sequence and integrate into the complementary growing strand by means of a polymerase. The... Agent: Genovoxx Gmbh

20140295435 - Method for detecting bacillus anthracis: A method for detecting Bacillus Anthracis comprises steps: obtaining DNA of a sample; respectively mixing the DNA with Primer Sets pXO1, pXO2 and PL3 to form a first reactant mixture, a second reactant mixture and a third reactant mixture, wherein the Primer Sets pXO1, pXO2 and PL3 are respectively sequences... Agent: Genereach Biotechnology Corp.

20140295445 - Method for the carry-over protection in dna amplification systems targeting methylation analysis achieved by a modified pre-treatment of nucleic acids: Particular aspects provide methods for specific amplification of template DNA in the presence of potentially contaminating PCR products from previous amplification experiments. Particular embodiments comprise, in a first step, contacting DNA with a bisulfite solution, which sulfonates unmethylated (but not methylated) cytosines, resulting in cytosine deamination and generation of sulfonated... Agent: Epigenomics Ag

20140295433 - Method of detection using nano carbon carrier modified by ionizing radiation: A detection method for cancer is provided. Magnetic carbon beads are used. The carbon beads are highly specified to a cancer. Surface area of grafted antigen are broadened by grafting functional molecules. Number of antigen is increased on the surface. Thus, the present invention improves sensitivity and accuracy of disease... Agent: Institute Of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.o.c.

20140295436 - Methods for multiplexing recombinase polymerase amplification: This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.... Agent: Alere San Diego, Inc.

20140295446 - Methods, compositions, and kits for rare allele detection: Methods and kits are provided for nucleic acid analysis. In an illustrative method, Snapback-ARMS primers are used to amplify preferentially a target nucleic acid that is present in a low allele fraction. In another embodiment, tailed primers are used to identify the preferentially amplified allele.... Agent:

20140295442 - Modulation of microglia activation: The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by administering cells that modulate microglia activation. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to... Agent: Abt Holding Company

20140295439 - Nucleic acid amplification: Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as restriction enzymes, polymerases, ligases, primers, and polynucleotide adaptors.... Agent:

20140295440 - Nucleic acid amplification: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such nucleic acid polymerases and primers.... Agent:

20140295443 - Polynucleotide sequences of candida dubliniensis and probes for detection: The present invention relates to identification of centromeric sequences of Candida dubliniensis and localization of CdCse4p centromeric histone to the identified region. Also the present invention relates to distinguishing Candida dubliniensis from other members of genus Candida.... Agent: Jawaharlal Nehru Centre For Advanced Scientific Research

20140295447 - Primer set, method for amplifying target nucleic acid sequence using same, and method for detecting mutated nucleic acid using same: The present invention provides a primer set including primers that can be designed easily, with which an amplification distance can be shortened. Provided is a primer set for use in a method for isothermally amplifying a target nucleic acid sequence 4. The primer set includes a first primer 1F and... Agent: Riken

20140295448 - Suppression of tla2-cpftsy gene expression for improved solar energy conversion efficiency and photosynthetic productivity in algae: The invention provides method and compositions to minimize the chlorophyll antenna size of photosynthesis by decreasing TLA2 gene expression, thereby improving solar conversion efficiencies and photosynthetic productivity in green microalgae, under bright sunlight conditions.... Agent: The Regents Of The University Of California

20140295449 - Screening method for selected amino lipid-containing compositions: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.... Agent: Tekmira Pharmaceuticals, Inc.

20140295450 - Cell analyzing method and cell analyzer: The present invention provides a method for analyzing a cell. The method comprises steps of: regulating a temperature of a medium to a predetermined degree, wherein the cell is preserved in the medium; and obtaining an optical information by irradiating light on the cell.... Agent: Sysmex Corporation

20140295452 - Anti-cmet antibody and its use for the detection and the diagnosis of cancer: The present invention relates to the field of prognosis and/or diagnosis of a proliferative disease in a patient. More particularly, the invention relates to a novel antibody capable of binding specifically to the human cMet receptor, as well as the amino acid and nucleic acid sequences coding for this antibody.... Agent: Pierre Fabre Medicament

20140295451 - Method, composition and kit of visualisation and characterization of the nervous system by combining the staining for metal impregnation and immunohistochemistry: A method of visualization and characterization of the nervous system, which combines two techniques for tissue staining, mercuric impregnation and immunohistochemistry, is described. The method disclosed makes compatible one with the other procedures of staining by carrying them out on tissues subjected to adequate fixing procedures. Thus, the method makes... Agent: Universita Degli Studi Di Cagliari

20140295453 - Sample analyzer, sample analysis method, and non-transitory storage medium: To provide a sample analyzer capable of accurately obtaining the number of analyzable samples. When analyzing a sample collected from a subject, a CPU of the sample analyzer calculates the number of analyzable samples based on a remaining number of tests of a reagent set in a reagent holding section... Agent: Sysmex Corporation

20140295454 - Variants of vegfr and their use in the diagnosis and treatment of pregnancy associated medical conditions: An isolated polypeptide comprising an amino acid sequence at least 70% homologous to SEQ ID NO: 4 and an isolated polynucleotide encoding same are disclosed. A polynucleotide comprising a nucleic acid sequence capable of specifically hybridizing to the isolated polynucleotide and an isolated antibody comprising an antigen recognition domain which... Agent:

20140295458 - Method of reversibly staining a target cell: The present invention relates to methods of reversibly staining a target cell. The invention also relates to methods of isolating a target cell or a target cell population that is defined by the presence of at least one common specific receptor molecule. The invention also provides kits that can be... Agent: Iba Gmbh

20140295460 - Analyte detection using magnetic hall effect: Determining a presence of a target analyte in a fluid sample includes mixing multiple magnetic particles with the fluid sample, in which the magnetic particles are each bound to one or more binding moieties that specifically bind to the target analyte, flowing the fluid sample containing the magnetic particles through... Agent: The General Hospital Corporation

20140295459 - Markers for identifying tumor cells, methods and kit thereof: The present disclosure relates to a combination of biological markers for identification of prognosis of cancer. The present disclosure further relates to a method of identifying the said markers, a method of predicting prognosis and a method of planning personalized treatment for cancer. The present disclosure further relates to a... Agent:

20140295455 - Antibody for detecting epithelial ovarian cancer marker and method for diagnosing epithelial ovarian cancer: The present invention provides an antibody capable of specifically recognizing and detecting the highly specific cancer marker with respect to the epithelial ovarian cancer, or a fragment of the antibody. The present invention provides an anti-β1,3-N-acetylglucosaminyltransferase 3 antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection of... Agent: National Institute Of Advanced Industrial Science And Technology

20140295457 - Gene cluster for biosynthesis of griselimycin and methylgriselimycin: The present invention refers to the gene cluster and genes comprised by the gene cluster which are involved in the biosynthesis of griselimycin and methylgriselimycin and to the use of the gene cluster, genes comprised thereby and proteins encoded thereby for the production of antibiotic agents.... Agent:

20140295456 - Renal cell carcinoma biomarkers: Disclosed herein is a method of identifying a tumor biomarker. In one example, a tumor biomarker is identified by obtaining a peripheral biological fluid sample from a subject with a tumor as well as a tumor sample and an adjacent non-tumor sample from such subject. A protein expression profile is... Agent:

20140295464 - Detection of degradation products of feline nt-probnp: A method for determining the amount of NT-proBNP in blood samples from felines. The method includes detecting degradation products of feline NT-proBNP by various methods, including using antibodies, kits and devices.... Agent:

20140295463 - Elisa detection of urine dek to predict and diagnose bladder cancer in humans: The present invention is directed to a method of detecting a DEK protein in a human urine sample using an ELISA assay. Methods and compositions for detection of DEK using mAb 260-6F9F6 (as detection antibody) and mAb 16-2C9C3 (as capture antibody) in human urine are provided herein. Specifically, the ELISA... Agent: Medical Diagnostic Laboratories, LLC

20140295467 - Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients not undergoing statin treatment: The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific... Agent:

20140295466 - Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment: The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific... Agent:

20140295461 - Method for determining lung injury using desmosine and isodesmosine as biomarkers: The subject invention is directed to a method for biochemically determining the extent of emphysematous changes in the lung. This method is entirely novel in that it links a biochemical parameter (the ratio of free to peptide-bound desmosine and isodesmosine [DID]) to specific morphological changes in lung tissue consisting of... Agent:

20140295462 - Rbm3 protein in colorectal cancer prognostics: e

20140295465 - Use of an anti-alpha-synuclein antibody to diagnose an elevated level of alpha-synuclein in the brain: This disclosure relates to the use of anti-α-synuclein antibody to diagnose an elevated level of α-synuclein in the brain. Specifically, the disclosure relates to the method of assessing the levels of α-synuclein in a blood plasma or CSF following administration to the test subject of an anti-α-synuclein antibody or antigen-binding... Agent: Biogen Idec International Neuroscience Gmbh

20140295469 - In vitro assessment of cardiovascular events by assay for neo-eptitopes of titin protein: i

20140295468 - Test substance assay method, test substance assay kit, and test substance assay reagent: The test substance assay method includes (i) obtaining a mixed solution by mixing (a) first dry particles that are modified with first binding substances exhibiting binding properties specific to a test substance, have an average particle size of 100 nm to 200 nm, and have labels, and (b) second dry... Agent: Fujifilm Corporation

20140295471 - Determination of the thrombogenic power of human immunoglobulins: A kit for the determination of the thrombogenic power of human immunoglobulins contained in a biologically acceptable product. Also a process making it possible to determine the thrombogenic power linked to the presence of activated Factor XI and/or activated Factor IX and/or activated Factor XII, and/or activated Factor VII and/or... Agent:

20140295470 - Method and reagent kit for measuring activated partial thromboplastin time: The present invention provides a method for measuring activated partial thromboplastin time. The method comprises: a first mixing step of mixing a blood plasma with a first reagent, wherein the first reagent comprises an activator and phosphatidylglycerol at a concentration equal to or greater than 25 μg/mL; a second mixing... Agent: Sysmex Corporation

20140295472 - Paper based diagnostic test: A device utilizing agglutination and its method of use to diagnose diseases or conditions. The diagnostic device may comprise a substrate having pores, an agglutination zone, and a test readout zone wherein said agglutination zone is functionalized with an agglutinating agent to cause agglutination of the sample.... Agent: The Administrators Of The Tulane Educational Fund

20140295473 - Method and test mixtures for detecting the presence or absence of target microbes in a test sample: A method of and test mixture for detecting the presence or absence of a target microbe in a sample is provided. The method includes the steps of: a) providing a test mixture that includes micro particles, a substrate in an amount that is sufficient to support log phase growth of... Agent:

20140295474 - Method for dissolution testing of solid compositions containing digestive enzymes: The invention is directed to a process for measuring the amount of digestive enzymes released from a solid composition in a dissolution medium by fluorescence spectroscopy. The invention is also directed to a combined method for measuring both the dissolution and gastroresistance of a solid compositions comprising pancrelipase.... Agent: Aptalis Pharma Ltd.

20140295475 - Enzyme cocktails prepared from mixed cultures: The application provides methods of producing a mixture of enzymes using two or more cell lines, methods of identifying or constructing cell lines for producing a mixture of enzymes, and methods of preparing a cell bank for producing a mixture of enzymes.... Agent: Danisco US Inc.

20140295476 - Glutamate oxidase mutagenesis for diagnostic testing: The described invention provides a method of generating a catalytically active oxidase enzyme preparation. The described invention also provides a means of generating reagents for a protease detection sensor which can use colorimetric, fluorescent, or electrochemical detection. Further, the invention describes a system for a protease detecting sensor.... Agent: Abbott Point Of Care Inc.

20140295477 - Kit for sampling and detection of endotoxin in aqueous solution: The present invention relates to a simple, rapid, and cost-effective test kit for detecting bacterial endotoxin in aqueous solutions, such as water for dialysis or dialysate, using an endotoxin-activatable clotting agent-based gel clot assay which can be applied at ambient temperature. The present invention also relates to a method of... Agent: Fresenius Medical Care Holdings, Inc

20140295478 - Bacterial surrogate for testing of antimalarials: thya knockout and fola knockout bacteria for testing of inhibition of malarial dihydrofolate reductase-thymidylate synthase: The objective of this invention is to create a double thyA folA knockout Escherichia coli (E. coli) strain for antifolate screening against DHFR of malaria and other parasites. This strain is used together with a plasmid expressing DHFR-TS from the desired pathogenic organism, which constitutes an anti-DHFR assay against the... Agent: National Science And Technology Development Agency

20140295479 - Fluid processing and control: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid... Agent: Cepheid

20140295482 - Media compositions for promoting bacterial and fungal growth: Methods and compositions for enhancing or promoting germination of bacterial spores, and yeasts are disclosed herein. The composition of the present invention comprises an extract obtained from banana or any member belonging to the genus Musa that may be used alone or in a growth medium to promote and enhance... Agent:

20140295480 - Metal sulfide and rare-earth phosphate nanostructures and methods of making same: The present invention provides a method of producing a crystalline metal sulfide nanostructure. The metal is a transitional metal or a Group IV metal. In the method, a porous membrane is placed between a metal precursor solution and a sulfur precursor solution. The metal cations of the metal precursor solution... Agent: The Research Foundation For The State University Of New York

20140295481 - Method for screening a drug in retinal tissue: The subject matter disclosed herein pertains to a method for screening drugs using second-harmonic generation microscopy. The tissue is scanned with a pulsed laser light which has an excitation wavelength. At least some of microtubules within the tissue produce generated light with a second-harmonic wavelength that is half the excitation... Agent: Research Foundation Of The State University Of New York

20140295483 - Apparatus and method for in-vitro drug screening for cancer metastasis: The present invention includes an apparatus and methods for detecting cancer cell metastasis, the apparatus comprising: a multi-well plate for growing cells in tissue culture; one or more shafts, cones, or fins that fit within one or more of the wells of the multi-well plate and that can be positioned... Agent: Board Of Regents, The University Of Texas System

20140295486 - Biological detector and method: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization... Agent: Stc.unm

20140295487 - Blood cell analyzer and blood cell analyzing method: A blood cell analyzer comprises a flow cell configured to flow a measurement specimen containing blood cells, a first light source configured to emit light having a first wavelength, a second light source configured to emit light having a second wavelength different from the first wavelength, a first light receiving... Agent: Sysmex Corporation

20140295488 - Blood cell analyzer and blood cell analyzing method: A blood cell analyzer comprising a flow cell configured to flow a measurement specimen containing blood cells, a first light source configured to emit light having a first wavelength, a second light source configured to emit light having a second wavelength different from the first wavelength, a first light receiving... Agent: Sysmex Corporation

20140295484 - Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity: The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes... Agent: The Regents Of The University Of California

20140295485 - Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity: The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes... Agent: The Regents Of The University Of California

20140295489 - Organic compounds: The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the... Agent:

20140295490 - Fetal red blood cell detection: A device for analyzing a maternal blood sample for quantification of the percentage of fetal red blood cells present with respect to the number of maternal red blood cells includes reagents for mixing with the biological sample, a microfluidic chip, 5 fluid reservoirs, a pumping system, an image acquisition system,... Agent: Asta Fluidic Technologies, Inc.

20140295491 - Duckweed hydrolysate and use thereof: A duckweed hydrolysate is provided. A method for producing carotenoids comprising the incubation of microorganisms with the duckweed is also provided.... Agent: Lemnaceae Fermentation, Inc.

20140295492 - Methods for cell-free protein synthesis: Cell-free protein synthesis systems and methods of using the same for producing in vitro protein materials in high yield are disclosed. The cell-free protein synthesis platform includes (a) a Saccharomyces cerevisiae cellular extract prepared from mid-exponential to late-exponential batch cultures in the range from about 6 OD600 to about 18... Agent: Northwestern University

20140295493 - Polypeptides having protease activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent:

20140295494 - High affinity, anti-human ige antibodies: The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These... Agent: Tanox, Inc.

20140295495 - Methods of preventing and removing trisulfide bonds: The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of... Agent: Biogen Idec Ma Inc.

20140295496 - Recombinant baculovirus and use thereof: e

20140295497 - Vectors and host cells comprising a modified sv40 promoter for protein expression: The present disclosure is directed to expression vectors, comprising a weakened SV40 promoter, and recombinant mammalian cells capable of producing high levels of a polypeptide of interest, methods of generating and using such recombinant mammalian cells.... Agent:

20140295500 - Dna polymerases with improved activity: Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.... Agent:

20140295499 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecular Systems, Inc.

20140295498 - Targeted rolling circle amplification: Methods for amplifying a desired target region of a nucleic acid through rolling circle amplification with a strand-displacing polymerase are provided. Concatameric hairpin products are resolved with endonuclease digestion, and the resulting amplified product hairpins or fragments can be circularized and employed as templates in a subsequent round of amplification.... Agent: Pacific Biosciences Of California, Inc.

20140295501 - Novel method to load a mammalian artificial chromosome with multiple genes: The invention provides for a system for uploading genes of interest into an artificial chromosome expression system (ACE) that has been engineered to include multiple sites for site-specific, recombination directed integration, whereby a second or further gene of interest can be loaded onto the ACE by a targeting vector, through... Agent:

20140295502 - Cdna synthesis improvements: The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for... Agent:

20140295503 - Methods and devices for biological sample preparation: Various aspects and embodiments of the present disclosure relate to methods of obtaining and manipulating nucleic acids from samples. In some embodiments, the samples are known to comprise or are suspected of comprising microorganisms such as bacteria and the methods of the invention are used to identify such microorganisms.... Agent: Pathogenetix, Inc.

20140295504 - Fungal cells and fermentation processes: The present invention provides an isolated fungal cell that is capable of producing one or more biomass-degrading enzymes and that exhibits increased or decreased expression or copy number of a polynucleotide encoding a PtaB-like protein. Also provided is a fermentation processes for producing one or more biomass-degrading enzymes comprising a... Agent:

20140295505 - Process for the recovery of betaine from molasses: A process for the recovery of betaine from a raw material consisting essentially of molasses. The process includes a demineralisation step, a conversion step and a separation step. In the demineralisation step the overall amount of salts in the molasses is brought to a level lying below 2 wt. %... Agent:

20140295506 - Method to produce hydrazide: A method to produce hydrazide from triacylglycerol, the method includes steps of mixing vegetable oil with an organic solvent in a reactor forming a mixture, adding hydrazinemonohydrate into the mixture, stirring the mixture, adding catalyst, stirring the mixture to form hydrazide and separating the hydrazide from the mixture. Most illustrative... Agent: Universiti Putra Malaysia

20140295507 - Method for producing biodegradable polymer and biomass fuel converted from carbon source by recombinant microorganisms: Disclosed is a method for producing biodegradable polymer and ethanol converted from carbon source by using recombinant microorganisms, comprising the steps of: (A) providing recombinant microorganisms transformed with plasmids containing at least a gene encoding for glycerol utilizing enzyme and a gene encoding for polyhydroxyalkanoate synthase; (B) culturing the recombinant... Agent:

20140295508 - Methods for preparing 2,5-furandicarboxylic acid: Provided are methods of producing 2,5-furandicarboxylic acid (FDCA) from renewable sources such as seaweed, alginate, oligoalginate, pectin, oligopectin, polygalacturonate, galacturonate, and/or oligogalacturonate. The sugars in the renewable sources can be converted into one or more intermediates such as 4-deoxy-L-erythro-5-hexoseulose uronate (DEHU), 4-deoxy-L-threo-5-hexosulose uronate (DTHU), 5-hydroxymethyl furfural (HMF), 2,5-dihydroxymethyl furan (DHMF),... Agent:

20140295509 - Pre-treatment of cellulosic material: A method of pre-treating a cellulosic material before hydrolysis is provided. The method comprises the steps of: impregnating the cellulosic material with a reactive water-soluble gas, such as sulphur dioxide (SO2) or carbon dioxide (CO2), in an impregnation chamber to obtain impregnated material; and heating the impregnated material to obtain... Agent: Sekab E-technology Ab

20140295510 - Eukaryotic cell and method for producing glycolic acid: The present invention concerns a eukaryotic host selected from microorganisms, and a method for producing glycolic acid using said eukaryotic host cells, especially cells of a genetically modified fungal host. Further this invention relates to a glycolic acid product obtained using the method described here and the use of genetically... Agent:

20140295511 - Organisms for the production of 1,3-butanediol: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate... Agent: Genomatica, Inc.

20140295513 - High-performance ketol-acid reductoisomerases: The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or a modified NADH-dependent variant thereof, wherein said KARI is at least about 80% identical to SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO:... Agent: Gevo, Inc.

20140295512 - Ketol-acid reductoisomerases with improved performance properties: The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or modified NADH-dependent variant thereof, wherein said KARI is at least about 60% identical to SEQ ID NO: 2. In various aspects of the invention, the recombinant microorganisms may comprise an... Agent: Gevo, Inc.

20140295514 - Fermentative glycerol-free ethanol production: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising... Agent: Technische Universiteit Delft

20140295515 - Crude glycerol fermenting process for the production of ethanol and hydrogen: The present invention concerns a fermenting process of crude glycerol derived from biodiesel production for preparation of ethanol and hydrogen using activated sludge enriched and directly acclimatized on biodiesel by-product... Agent:

20140295516 - Genetically modified strain of s. cerevisiae engineered to ferment xylose and arabinose: The present invention provides a microorganism capable of fermenting arabmose to a desired product such as ethanol. In some embodiments, the organism is also capable of fermenting xylose. In some embodiments, the organism is capable of fermenting arabinose and xylose, and expresses one or more cellulases.... Agent:

20140295517 - Host cells and constructs useful for producing pinene: The present invention provides for a modified host cell comprising a heterologous pinene synthase (PS), or enzymatically active fragment or variant thereof, and optionally a geranyl pyrophosphate synthase (GPPS), or enzymatically active fragment or variant thereof, or a fusion protein comprising: (a) a PS and (b) a GPPS linked by... Agent: The Regents Of The University Of California

20140295518 - Process for generation of hydrogen and syngas: The present invention is related to a process for generation of hydrogen and syngas based on biomimetic carbonation and photocatalysis. A path breaking way has been developed for generation of solar fuels in specific hydrogen by coupling biomimetic carbonation with photocatalysis. Efforts are being made worldwide to mimic the reaction... Agent: Council Of Scientific & Industrial Research

20140295519 - Thermococcus mutant having improved hydrogen production from formate and methods of hydrogen production by using thereof: The present invention relates to a Thermococcus onnurineus NA1 mutant having an increased ability to produce hydrogen from formate and a method of producing hydrogen the same. The Thermococcus onnurineus NA1 mutant according to the invention has an increased ability to produce hydrogen in a formate-containing medium compared to wild-type... Agent: Korea Institute Of Ocean Science & Technology

20140295520 - Engineered subcellular compartments: This disclosure describes a cell that includes an engineered subcellular compartment that generally includes a proteinaceous shell that includes at least one bacterial microcompartment (BMC) polypeptide. In some embodiments, the engineered subcellular compartment can further include one or more targeted enzymes. We further describe methods of making and using such... Agent: Regents Of The University Of Minnesota

20140295521 - Method for reducing the immune response to a biologically active protein: A new use of a molecule comprising at least one moiety which is a biologically active protein and at least one moiety capable of binding to a serum albumin of a mammal is provided, for preparation of a medicament which elicits no or a reduced immune response upon administration to... Agent: Affibody Ab

20140295522 - Storage-stable liquid detergent or cleaning agent containing protease and amylase: The intention is to improve storage stability in a liquid washing or cleaning agent which contains a protease and amylase. This is achieved by using a protease which comprises an amino acid sequence which, over the entire length thereof, is at least 70% identical to the amino acid sequence stated... Agent:

20140295523 - Glucanases, nucleic acids encoding them and methods for making and using them: The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-D-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-D-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl... Agent: Bp Corporation North America Inc.

20140295525 - Method for producing cellulase and apparatus for said method: A method of producing cellulase includes steps (1) to (3): (1) subjecting an aqueous solution of cellulase derived from filamentaous fungi to filtration through an ultrafiltration membrane with a molecular weight cut off of 100,000 to 200,000 to obtain a filtrate and concurrently obtain a concentrated enzyme liquid as a... Agent:

20140295524 - Process for the continuous production of cellulases by a filamentous fungus using a carbon substrate obtained from an acid pretreatment: A process for the production of cellulases and hemicellulases using a strain of a filamentous fungus in a stirred and aerated bioreactor, in at least two phases, a phase a) for growth of said strain in the presence of at least one carbonaceous growth substrate in a closed reactor, a... Agent:

20140295526 - Modified proteases: This invention relates to modified polynucleotides encoding modified proteases, and methods for altering the production of proteases in microorganisms. In particular, the present invention relates to methods for altering the expression of proteases in microorganisms, such as Bacillus species. The invention discloses modified polynucleotides, vectors, modified polypeptides, and processes for... Agent: Danisco US Inc.

20140295527 - Compositions and methods comprising a subtilisin variant: The present invention provides a Bacillus sp. subtilisin variant. In addition, the present invention provides automatic dishwashing compositions comprising this serine protease variant.... Agent: Danisco US Inc.

20140295528 - Novelpolypeptides and bacteriophages specific to klebsiella pneumoniae capsular type strains: The present invention relates to novel bacteriophages specific to Klebsiella pneumoniae strains, and compositions comprising the same. Particularly, polypeptides and their coding nucleic acid molecule of the novel bacteriophages are provided. The invention also relates to applications of the novel bacteriophages and the polypeptides in the detection/treatment/prevention of infection caused... Agent: National Taiwan University

20140295529 - Compositions comprising eicosapentaenoic acid suitable for high purification: The invention relates to a microbial biomass composition produced from a heterotrophic fermentation whose fatty acid profile exhibits an eicosapentaenoic acid (EPA) to arachidonic acid (ARA) ratio of about 11:1 or more, an EPA to total co-concentrating fatty acid ratio of about 8:1 or more, extract compositions, and methods of... Agent:

20140295530 - Method for increasing the coq10 and coqh2 content in phototrophic microorganisms: A method for increasing the content of ubiquinone (CoQ10) and ubiquinol (CoQH2) in phototrophic microorganisms that were cultivated in a culture medium in a bioreactor under light irradiation, wherein the phototrophic microorganisms are selected from the group consisting of blue algae, green algae and yellow-green algae, comprising a step of... Agent: Sanbo International Establishment

20140295531 - Enzyme promoted co2 capture integrated with algae production: The invention relates to the field of reduction of CO2 emission, more in particular to CO2 capture and conversion. The invention further relates to the culturing of algae. One object of the present invention is to provide an alternative method for capturing and conversion of CO2 from a gaseous stream.... Agent: Nederlandse Organisatie Voor Toegepast-natuurwetenschappelijk Onderzoek Tno

20140295532 - Systems and methods for producing bioproducts: The present disclosure is directed to systems and methods for sampling and/or controlling the productivity of a bioreactor.... Agent: Bend Research, Inc.

20140295533 - Enhanced microfluidic valves for media diagnostics: The invention provides a micro-fluidic device that includes a pre-loaded sample that begins to flow only when a sample is provided in the device. In certain embodiments, the invention provides a micro-fluidic device including at least two paper flow path layers providing fluid flow in substantially parallel planar directions, and... Agent: Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations

20140295534 - Systems and devices for isothermal biochemical reactions and/or analysis: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters,... Agent:

20140295538 - Device and system for mechanical measurement of biomaterial: A test device applies a defined mechanical load to a soft biomaterial such as a cell culture and a microscope forms a volume image data set showing the strain field or displacement field occurring in the medium. The data set is processed to determine fundamental mechanical properties of the cell,... Agent:

20140295535 - Measurement apparatus: A measurement apparatus includes: a holding unit that holds at least a specimen to be observed; an illumination unit that emits illumination light to be irradiated to the specimen; a detection unit that is arrangeably provided in the holding unit and detects an intensity of the illumination light on a... Agent: Olympus Corporation

20140295536 - Particle measuring apparatus: A particle measuring apparatus comprising a flow cell configured to flow a specimen, a first light source configured to emit light having a first wavelength, a second light source configured to emit light having a second wavelength different from the first wavelength, an irradiation optical system configured to irradiate the... Agent: Sysmex Corporation

20140295537 - Sanitizing floor mat: The present invention is comprised of an antibacterial door mat system for cleaning, disinfecting and detection of bacteria and other organisms on footwear to control spread of biological infections and contamination. The present invention is further comprised of an antibacterial door mat that cleans footwear, detects the presence of bacteria... Agent:

20140295539 - Container for culturing cells having nanostructures, and preparation method thereof: A container for culturing cells having nanostructures according to the present invention comprises a cell culture surface onto which adult stem cells are adhered so as to be proliferated and differentiated, wherein the cell culture surface comprises nanostructures placed thereon at regular intervals, the nanostructures comprise nano-pillars protruded from the... Agent: Postech Academy-industry Foundation

20140295540 - Means for generating adenoviral vectors for cloning large nucleic acids: c

20140295541 - Cell culture device, cell culture system, and cell culture method: To provide a cell culture device, a cell culture system and a cell culture method capable of suppressing fluctuations in pressure in a culture fluid, and suppressing gas bubbles from flowing into a cell culture section. A cell culture device including: a cell culture section that cultures cells; a storage... Agent: Arkray, Inc.

20140295542 - Cell separation compositions and methods for separating and recovering therapeutic cells in blood tissue: Embodiments provide a cell separation composition and methods for separating and recovering desired therapeutic cells in a blood tissue sample.... Agent: Bhc Technology Holdings LLC

20140295544 - Fluorescent proteins with increased activity in cells: The present invention relates to fluorescent proteins, in particular green fluorescent proteins (GFPs), with increased activity in cells, and thus increased signal strength. A further aspect of the present invention relates to the use of peptides for increasing the expression and/or stability of a protein in a cell.... Agent:

20140295543 - Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference: The present invention concerns methods and compositions involving RNase III and polypeptides containing RNase III domains to generate RNA capable of triggering RNA-mediated interference (RNAi) in a cell. In some embodiments, the RNase III is from a prokaryote. RNase III activity will cleave a double-stranded RNA molecule into short RNA... Agent: Applied Biosystems, LLC

20140295545 - Pre-programmed non-feedback controlled continuous feeding of cell cultures: A pre-programmed non-feedback continuous feeding method based on mass balance of the substrate in the bioreactor for use in culture growth and maintenance is provided. The disclosed method does not rely on instrument, probe or operator feedback. The method provides an efficient and effective alternative to bolus feeding.... Agent: Amgen Inc.

20140295546 - Fluid distribution in a sample exposure device: The invention relates to fluid distribution in an exposure device. The exposure device, in some examples, is a device for exposing living cell cultures or cellular tissues to a fluid such as cigarette smoke, air and/or other gases or gas mixtures, for use in studies of the effects on the... Agent: British American Tobacco (investments) Limited

20140295547 - Method to construct in-vitro human blood brain barrier model: A method to construct an in-vitro human blood brain barrier (BBB) model is disclosed, which comprises steps: attaching suspension liquids of human brain vascular pericytes (HBVPs) and human astrocytes (HAs) by a ratio of 1:1, 1:2, or 1:6 to a bottom surface of a filter membrane of a culture dish... Agent: National Chung Cheng University

20140295548 - Bioartificial liver system: A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes.... Agent:

20140295550 - Hla peptide therapy: The invention provides polypeptides derived from a major histocompatibility complex (MHC) class I human leukocyte antigen (HLA), such as HLA-A2, and derivatives or analogues thereof. The polypeptides, derivatives and analogues can be used to treat or prevent allosensitisation, such as the treatment or prevention of allograft rejection.... Agent: The University Of Birmingham

20140295549 - Methods and compositions for inducing apoptosis by stimulating er stress: The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering... Agent: University Of Southern California

20140295553 - In-vitro cell colony culture device and use thereof: Provided are an in-vitro cell colony culture device and use thereof, the in-vitro cell colony culture device comprising: a micro-patterned template having a micro-patterned cavity, and adhesive hydrogel formed on the lower surface of the micro-patterned template, and the micro-patterned cavity defining the growth space of the cell colony. An... Agent:

20140295551 - Protein markers associated bone marrow stem cell differentiation into early progentior cells: A novel cytosolic 58 kd phosphoprotein induced during bone marrow stem cell (BM) differentiation into dendritic cells (DC) during in vitro cultivation with the cytokine GM-CSF by addition of antisera to an 82 kd BM cell surface protein generating cultivatable dendritic progenitor cells (DP). Genes, methods for preparing them as... Agent:

20140295552 - Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells: The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. Specifically, the invention discloses methods of differentiating pluripotent cells into beta cell, cardiac cell and neuronal cell lineages using suspension clustering. The methods involve preparing the aggregated cell clusters followed by differentiation of these clusters.... Agent:

20140295554 - Method for manufacturing umbilical cord extract and usage of the same: The present invention provides a method for effectively extracting useful ingredients from an umbilical cord. The present invention provides an umbilical cord extract including the useful ingredients. The umbilical cord extract, according to the present invention, can be used as a serum substitute for cultivating ordinary cells and stem cells... Agent: Cha Bio & Diostech Co., Ltd.

20140295555 - Method of culturing cells: A blood component such as platelets is concentrated. The concentrate, such as platelet-rich plasma, is used in a cell culture medium to grow and proliferate cells. The cells may be from the same person from which the blood concentrate is obtained. The cells grown in the culture medium may be... Agent:

20140295556 - Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.... Agent: The General Hospital Corporation

20140295557 - Using truncated guide rnas (tru-grnas) to increase specificity for rna-guided genome editing: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).... Agent: The General Hospital Corporation

20140295558 - Method and apparatus for delivery of molecules to cells: The present invention is concerned with a system and method for introducing a substance into cells. The system has an assembly including a plurality of elongate non-hollow nanoneedles forming a nanoneedle array or patch for delivering the substance into the cells, at least some of the nanoneedles have a non-uniform... Agent: City University Of Hong Kong

  
09/25/2014 > 112 patent applications in 64 patent subcategories.

20140287402 - Method for screening cells: The invention relates to high throughput screening methods for identifying, isolating and retrieving cells secreting antibodies of interest, e.g., having functional activity and/or multi-antigen specificities. It further provides methods for the cloning of said antibodies VH/VL sequences and the generation of recombinant monoclonal antibodies derived thereof having the features of... Agent: Valneva

20140287403 - Nanoscale motion detector: Motion detector comprising a flexible support (1,5) adapted to hold at least one object (6-9), a sensor (4) for measuring the displacement of said support (1) and processing means for differentiating the fluctuations of said support (1) from those induced by said object (6-9).... Agent: Ecole Polytechnique Federale De Lausanne (epfl)

20140287412 - Acf detection method: The present invention provides a method for detecting ACF by analyzing a test region of large intestine tissue at the molecular level. Namely, the present invention relates to a method for detecting aberrant crypt foci (ACF) that comprises detecting an ACF detection marker in a test region of large intestine... Agent: The University Of Tokushima

20140287411 - Compositions, kits and related methods for the detection and/or monitoring of listeria: Provided are compositions, kits, and methods for the identification of Listeria. In certain aspects and embodiments, the compositions, kits, and methods may provide improvements in relation to specificity, sensitivity, and speed of detection.... Agent:

20140287406 - Corn plant mon88017 and compositions and methods for detection thereof: The present invention provides a corn plant designated MON88017 and DNA compositions contained therein. Also provided are assays for detecting the presence of the corn plant MON88017 based on a DNA sequence and the use of this DNA sequence as a molecular marker in a DNA detection method.... Agent: Monsanto Technology LLC

20140287409 - Detection and assessment of cancer risk using telomere health: Compositions and methods related to assessing the risk of cancer, such as breast cancer, lung cancer and bladder cancer, through analyzing the length of telomeres, such as chromosome 9p, 15p, and/or Xp telomere, such as the short arm of the 9p, 15p, and/or Xp telomere.... Agent: Georgetown University

20140287404 - Detection of bisulfite converted nucleotide sequences: The invention is to improved compositions and methods for the detection of target bisulfite converted methylated nucleotide sequences.... Agent:

20140287405 - Method for detecting and quantifying wheat endogenous gene: Provided is a method of detecting or quantifying a wheat species-specific DNA in a test sample by polymerase chain reaction. The method comprises a step of amplifying a nucleic acid molecule having a partial sequence of a nucleotide sequence identified as SEQ ID NO: 1 using a nucleic acid molecule... Agent: Nisshin Seifun Group Inc.

20140287413 - Methods, compositions, and devices utilizing microrna to determine physiological conditions: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.... Agent: Institute For Systems Biology

20140287410 - Probe:antiprobe compositions for high specificity dna or rna detection: Probe systems and methods are provided for detecting nucleic acid targets using labeled polynucleotide probes and antiprobes that interact together and with complementary targets. These interactions result in signaling changes that indicate target frequency and provide error-checking functions that facilitate single base discrimination. These probe:antiprobe compositions enable real-time PCR detection,... Agent:

20140287407 - System and method for analysis of plant material for a set of unique exogenous genetic elements: This disclosure concerns a system and method for detecting heterologous DNA in plant materials.... Agent: Dow Agrosciences LLC

20140287408 - Target sequence enrichment: The present invention provides methods, systems, kits, and compositions for magnetically purifying target nucleic acid sequences from a sample using bait molecules configured to bind both target nucleic acid sequences and magnetic binding particles. In certain embodiments, the bait molecules comprise a short target capture sequence (e.g., 18 to 48... Agent: Abbott Molecular Inc.

20140287418 - Composition for amplifying nucleic acids: The invention relates to a concentrated and buffered liquid composition for amplifying nucleic acids, comprising at least one dNTP, at least one enzyme required for the amplification, at least one oligonucleotide primer, and at least one fluorescent nucleotide probe, in the presence of a polyol and/or of polyvinylpyrrolidone (PVP).... Agent: Bio-rad Innovations

20140287419 - Compositions having dicamba decarboxylase activity and methods of use: Compositions and methods comprising polynucleotides and polypeptides having dicamba decarboxylase activity are provided. Further provided are nucleic acid constructs, host cells, plants, plant cells, explants, seeds and grain having the dicamba decarboxylase sequences. Various methods of employing the dicamba decarboxylase sequences are provided. Such methods include, for example, methods for... Agent:

20140287423 - Device and method for apportionment and manipulation of sample volumes: The present invention relates to methods and apparatus for apportionment and manipulation of sample volumes into smaller discrete volumes. The method exploits the interplay of hydrophilic and hydrophobic forces to partition sample volumes. These compartmentalized volumes allow for isolation of samples and partitioning into a localized array that can subsequently... Agent:

20140287417 - Egfr blood monitoring: Improved methods of assessing status of a solid-tumor cancer in a subject involving detection of tumor-associated mutations in the subject's blood.... Agent: Roche Molecular Systems, Inc.

20140287421 - Gene expression markers for breast cancer prognosis: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.... Agent: Genomic Health, Inc.

20140287422 - Method for selecting a treatment for non-small cell lung cancer using gene expression profiles: The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased lung. The present invention also identifies and quantifies expression profiles which serve as useful diagnostic markers as well as markers that are... Agent: University Of Toledo

20140287420 - Microfluidics polymerase chain reaction and high resolution melt detection: The present invention relates to a method and system for Polymerase Chain Reaction (“PCR”), High Resolution Melt (“HRM”) analysis and microfluidics, and, more specifically, to a method and system for implementing the processes of PCR and HRM on a microscale in a microfluidics chamber for certain purposes including for purposes... Agent: Syracuse University

20140287416 - Polyelectrolyte-coated size-exclusion ion-exchange particles: A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided.... Agent:

20140287415 - Polymerases: Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The... Agent: Illumina, Inc.

20140287414 - System and method for analyzing dna using application of mobile device: A DNA analysis system that controls DNA analysis by wireless using an application of a mobile device and a very small DNA analysis apparatus, and that receives a DNA analysis result in real time on the spot is provided. Therefore, by performing DNA analysis by simultaneously controlling a plurality of... Agent: Electronics And Telecommunications Research Institute

20140287424 - Slide chip for detection sensor of food-borne pathogens and preparation method thereof: The present invention relates to a slide chip for a sensor for detection of food-borne bacteria and a fabrication method thereof. More particularly, the invention relates to a slide chip for a sensor for detection of food-borne bacteria and a fabrication method thereof, the slide chip comprising: a substrate coated... Agent: Korea Food Research Institute

20140287425 - Glucose and insulin senors and methods of use thereof: Described herein are glucose and insulin sensors. The sensors are composed of host cells with DNA specifically designed to produce fluorescence when the cells come into contact with glucose and/or insulin in the sample. Once the fluorescence has been quantified, it can be correlated with the amount of glucose and/or... Agent: International Park Of Creativity

20140287426 - Antibody and antibody mimetic for visualization and ablation of endogenous proteins: Provided are compositions and methods for labeling an endogenous protein, in particular, in a live cell, or for ablating an endogenous or target protein. The compositions relate to a fusion protein having a binding moiety such as an antibody, an antigen binding fragment of an antibody or an antibody mimetic... Agent: University Of Southern California

20140287430 - Absorbent paper and use thereof for breast cancer detection: Biological samples of mammary fluid or components thereof are obtained using a breast pump device coupled with an absorbent paper or membrane, optionally facilitated by administering oxytocin to the subject. The breast pump device stimulates expression of mammary fluid and provides for collection of diagnostic samples on the absorbent paper... Agent:

20140287431 - Antibody specific to profilaggrin c-terminal domain, and use thereof: The present invention provides an antibody specific to a C-terminal domain of a human profilaggrin gene, wherein the C-terminal domain is a peptide comprising the amino acid sequence set forth in SEQ ID NO:1 or a variant thereof, a method for detecting a filaggrin gene mutation using the antibody, and... Agent:

20140287427 - Compositions and methods for capture of cellular targets of bioactive agents: The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture dimers), surfaces (e.g., displaying, capture ligands, capture... Agent: Promega Corporation

20140287428 - Method for detection of bacteria in milk: A method of detecting the presence of bacteria in milk is provided, wherein milk is contacted with a preparation which may comprise an effective amount of at least one type of antibodies, said antibodies being capable of specifically binding to bacteria to be detected; staining said antibodies, before or after... Agent:

20140287429 - Pretreatment solution for immunohistochemical staining and condensed solution thereof: Disclosed are a pretreatment solution for immunohistochemical staining, which elutes a paraffin-containing embedding medium from a glass slide with a tissue specimen embedded in the medium, and retrieves antigenicity of the tissue specimen, and which is usable three or more times, and a pretreatment solution concentrate for immunohistochemical staining which... Agent:

20140287435 - Kits, compositions and methods for detecting a biological: The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject... Agent:

20140287436 - Physical removal of biological agents detected by a magnecytometer: A system and method for analyzing a sample of liquid having an NMR signal in response to a magnetic field for the presence of an analyte. Included is an NMR device having a testing section that is adapted to contain a liquid and apply a magnetic field to the liquid.... Agent:

20140287437 - Magnetic separation of cells: An apparatus, system, and method for magnetic separation of cells are disclosed. By combining inkjet printing technology and magnetic labeling of cells, accurate cell counts are obtained using an optical microscope. Mouse CD4+ lymphocytes are attached to micron sized magnetic beads and printed through a modified, commercial inkjet printer. The... Agent: Board Of Regents, The University Of Texas System.

20140287438 - Rapid and inexpensive assay for evaluation of antibody efficacy with custom-designed fluorescent nanoparticles: A method for determining the efficacy of a vaccine comprising: providing serum from an animal inoculated with a vaccine; providing a plurality of antigen-linked nanoparticles; contacting the serum with the plurality of antigen linked nanoparticles; contacting the serum and the plurality of antigen linked nanoparticles with a plurality of Fc... Agent: South Dakota Board Of Regents

20140287432 - Diagnosis, prevention and treatment of disorders characterized by undesirable cell proliferation: The present invention relates to methods for the diagnosis, prevention and treatment of heart disease or heart failure in a subject. The present invention also relates to methods for the diagnosis, prevention and treatment of atherosclerosis with vulnerable plaque in a subject. Furthermore, the present invention relates to methods for... Agent:

20140287433 - Means and methods for determining clostridial neurotoxins: This invention relates to a method of determining presence, amount and/or activity of a clostridial neurotoxin in a sample, the method comprising or consisting of the following steps: (a) bringing said sample into contact with a liposome, said liposome comprising (aa) at least one receptor on its outer surface, said... Agent: Miprolab Gmbh

20140287434 - Methods of screening for and identifying compositions which modulate cellular kinase activities: The present invention relates to drug screening assays, therapeutic protocols and pharmaceutical compositions designed to target non-receptor tyrosine family kinases and components of the tyrosine kinase family signal transduction pathways. This includes primarily diseases or conditions associated with immune responses and can include treatment for cancers as well as various... Agent:

20140287439 - Method for manufacturing multiple-diagnosis membrane sensor by using screen printing: e

20140287443 - Characterization of cho-mif gene and protein, and use thereof: The present invention is concerned with the specific and highly sensitive detection of specific CHO-MIF (macrophage migration inhibitory factor from Chinese Ovarian Hamster cell line) complexes in the production of anti-MIF antibodies. The present invention is further concerned with the provision of specific antibodies which can be used for a... Agent:

20140287441 - Immunoassay for cyclopropylindole based synthetic cannabinoids, metabolites and derivatives thereof: The invention relates to the detection and quantification of cyclopropylindole based synthetic cannabinoids UR-144 and XLR-11 by providing antibodies based on novel immunogens. These antibodies can be incorporated into methods and kits for the detection of UR-144, XLR-11 and their metabolites.... Agent: Randox Laboratories Limited

20140287440 - Melittin peptide conjugates and methods employing same: Methods and reagents are disclosed for conducting assays for IgE specific for honey bee venom allergen. A reagent comprises a conjugate of a small molecule linked to a terminal glycine amino acid of a synthetic 26 amino acid melittin peptide. In the method a combination is provided that comprises a... Agent: Siemens Healthcare Diagnostics Inc.

20140287442 - Method for determining degree of modified potency of bipathic medicament: The invention comprises a method for determining degree of modified potency of a bipathic medicament. A bipathic medicine is a medicament comprising a therapeutic component and a homeopathic component, wherein the homeopathic component has some physical, chemical or biological affect on the therapeutic component and/or the pharmacological efficacy thereof. An... Agent:

20140287444 - Method of lipid assay and reagent for use therein: A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy... Agent: Sekisui Medical Co., Ltd.

20140287445 - Flavin-binding glucose dehydrogenase, method for producing flavin-binding glucose dehydrogenase, and glucose measurement method using thereof: A flavin-binding glucose dehydrogenase (FAD-GDH), which in addition to having high substrate specificity and adequate desirable heat stability, is suitable for efficient production, preferably using E. coli, yeast or molds and the like as host cells. The FAD-GDH has amino acid substitutions at positions equivalent to one or more locations... Agent:

20140287446 - Monoclonal antibody for acetylamantadine: A method of producing an antibody comprises immunizing a mammal with an amine-derivative of acetylamantadine, immunizing the mammal with acetylamantadine, and producing the antibody from the mammal. The antibody recognizes acetylamantadine but does not recognize amantadine.... Agent: Biomark Technologies Inc.

20140287447 - Ultrasensitive methodology for quantifying the kinase catalytic activity of any protein kinase in biological/clinical samples or recombinant/purified proteins using near-infrared-fluorescence (nirf)-labeled, kinase-selective peptide substrates and a combi: A non-radioactive, ultrasensitive methodology for the quantification of protein kinase catalytic activity of any protein kinase in, for example, biological/clinical samples or recombinant/purified proteins, based on using near-infrared-fluorescence (NIRF)-labeled peptide substrates that are selective for individual protein kinases and using a combination of kinase-selective inhibitors to define the catalytic activity... Agent:

20140287448 - Method for determining degree of modified potency of a medicament: The invention comprises a method for determining degree of modified potency of a medicament. A medicine is a medicament comprising a therapeutic component and a homeopathic, i.e., activated-potentiated, component, wherein the activated-potentiated component has some physical, chemical or biological affect on the therapeutic component and/or the pharmacological efficacy thereof. The... Agent:

20140287451 - Flow chambers, methods of using the flow chamber, and methods of making the flow chamber: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to a device (or “flow chamber”), methods of making a device, methods of using a device, and the like.... Agent: University Of Florida Research Foundation, Incorporated

20140287452 - Method for observing stem cells, method for removal of cell region in state tending toward differentiation, and device for observing stem cells: A method for observing stem cells by an observation device 1 comprises, placing stem cells C in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light L1 into the waveguide 21 and emitting the illumination light L1 to the stem... Agent: Hamamatsu Photonics K.k.

20140287450 - Methods for natural product optimization: Methods and compositions for natural product optimization are provided. In particular, methods and compositions for selecting bacterial strains (e.g., predatory bacteria such as myxobacteria) which produce a desired compound (e.g., antibiotic, antifungal, or anticancer agent) are provided.... Agent: The University Of Wyoming

20140287449 - Photosynthetic microorganism condition detection sensor: The present invention provides an optical probe apparatus and method for microorganism culture monitoring. The optical probe can be immersed within the microorganisms and include at least one emitter and at least two detectors that excite photosynthetic pigments in the culture medium. The optical probe can measure the culture spectral... Agent: 4-oem, LLC

20140287453 - Sample injection device for biochemical analysis, flow-type biochemical analysis device, and measurement method for hemoglobin component: When injecting a sample into carrier-liquid channels (3A and 3B), injection shock is prevented. Septa 13 and 14 constitute the upper wall and the lower wall of a sample injection part (11) of the carrier-liquid channels (3A and 3B). A needle (27) can vertically penetrate the septum (13) on the... Agent:

20140287454 - Susceptibility to selective cdk9 inhibitors: The present invention relates to a method of selecting (a) cell(s), (a) tissue(s) or (a) cell culture(s) with susceptibility to a selective CDK9 inhibitor. Also a method for determining the responsiveness of a mammalian tumor cell or cancer cell to treatment with a selective CDK9 inhibitor is described herein. In... Agent: Lead Discovery Center Gmbh

20140287455 - Microorganism detecting device evaluation kit, microorganism detecting device evaluation kit manufacturing method, and microorganism detecting device evaluating method: An evaluation kit for a microorganism detecting device includes an immobilized microorganism. A manufacturing method for an evaluation kit for a microorganism detecting device includes immobilizing a microorganism. An evaluating method for the microorganism detecting device includes detecting an immobilized microorganism by the microorganism detecting device. The immobilized microorganisms may... Agent: Azbil Corporation

20140287456 - Method of removing floatation liquid: A method of removing a floatation liquid from between a microscope slide and a paraffin embedded biological specimen including position the microscope slide with the paraffin embedded biological specimen floated thereon onto a slide support element. The slide support element is rotated to cause the microscope slide and the paraffin... Agent:

20140287461 - Method for producing sugar liquid: A method of producing a sugar liquid using a cellulose-containing biomass as a raw material includes (a) hydrolyzing a cellulose-containing biomass to produce an aqueous sugar solution and (b) filtering the obtained aqueous sugar solution through a reverse osmosis membrane to collect a purified sugar liquid from a feed side,... Agent: Toray Industries, Inc.

20140287458 - Photosynthetic process: The present invention provides a method of producing a photosynthetic product, the method comprising maintaining a photosynthetic plant or algal cell suspension culture, in the presence of water, light and a carbonic acid-enriched growth medium. The carbonic acid may, for example be provided by feeding the photosynthetic plant cell suspension... Agent: Naturally Scientific Technologies Limited

20140287460 - Production of recombinant protein in insect cells using a baculovirus expression system: The present invention describes a novel method for recombinant protein production using a baculovirus protein expression system in insect cells, wherein baculovirus virion production is suppressed during recombinant protein production. The novel expression system produces reduced levels of baculovirus virions during recombinant protein production phase, thereby reducing the need for... Agent: Gbiotech Sarl

20140287457 - Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins: A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic... Agent:

20140287459 - Temperature shift for high yield expression of polypeptides in yeast and other transformed cells: Methods for producing heterologous proteins are disclosed. In particular, the present disclosure provides improved methods of producing desired proteins, including multi-subunit proteins such as antibodies, with a higher yield and improved purity. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as Pichia pastoris.... Agent: Alderbio Holdings LLC

20140287462 - Gene inactivated mutants with altered protein production: A recombinant filamentous fungal cell (e.g. Aspergillus) having one or more inactivated chromosomal genes is provided. The chromosomal genes in some embodiments correspond to derA, derB, htmA, mnn9, mnn10, ochA, dpp4, dpp5, pepAa, pepAb, pepAc, pepAd, pepF and combinations thereof. The recombinant fungal cells may include further inactivated chromosomal genes... Agent: Danisco US Inc.

20140287463 - Engineered pichia strains with improved fermentation yield and n-glycosylation quality: The present invention relates to novel engineered Pichia strains with improved fermentation yields for expressing heterologous proteins with improved N-glycosylation quality, as well as to methods of generating such strains.... Agent:

20140287464 - In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris: The invention provides orthogonal translation systems for the production of polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris. Methods for producing polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris are also provided.... Agent:

20140287465 - Polypeptides having xylanase activity and polynucleotides encoding same: The present invention relates to polypeptides having xylanase activity, catalytic domains, and carbohydrate binding domains, and polynucleotides encoding the polypeptides, catalytic domains, and carbohydrate binding domains. The present invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using... Agent:

20140287466 - Process for the conversion of lignocellulose material into an organic acid: The invention relates to a process for the conversion of lignocellulose into an organic acid including an alkaline pretreatment step and a fermentation step, wherein liquid phase obtained in the fermentation step is recycled to the alkaline pretreatment step and/or the fermentation step. Organic acid is recovered as its magnesium... Agent: Purac Biochem B.v.

20140287467 - Processing biomass: Feedstocks, obtained at least in part from a plant material that has been modified with respect to its wild type, are processed to produce useful intermediates and products, such as energy, fuels, foods or materials. For example, systems are described that can treat such feedstock materials, e.g., to reduce the... Agent:

20140287468 - Enrichment of target sequences: Methods and compositions are provided for enriching for target sequences from a population of nucleic acids, that includes combining in solution, a population of nucleic acids and a target isolation probe wherein the target isolation probe includes an affinity binding domain; permitting a single stranded region of the target isolation... Agent: Directed Genomics, LLC

20140287469 - Filtration: Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can be useful for separating solids from liquids of saccharified biomass material slurries.... Agent:

20140287470 - Processing biomass and energy: Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels, heat and energy.... Agent:

20140287471 - Variant cbh i polypeptides with reduced product inhibition: The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids... Agent: Bp Corporation North America Inc.

20140287472 - Method for producing l-amino acids using bacteriua of the enterobacteriaceae family: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.... Agent: Ajinomoto Co., Inc.

20140287473 - Methods and compositions for enhanced production of organic substances from fermenting microorganisms: The present invention relates methods and compositions for producing an organic substance from fermenting microorganism using simultaneous saccharification and fermentation. One aspect of the invention provides producing alcohol by simultaneous saccharification and fermentation by combining a cellulosic substrate, and whole fermentation broth, and an ethanologenic microorganism under conditions conducive both... Agent: Danisco US Inc.

20140287474 - Method of treating organic material to produce methane gas: The present invention relates to a method of treating organic materials to produce methane gas, comprising the steps of: a) subjecting an organic feedstock comprising organic materials to a liquefaction process at subcritical conditions in at least one reaction stage, to obtain a mixture containing low molecular weight materials and... Agent: Reacfuel Ab

20140287475 - Methods for eliminating or reducing the expression of a gene in a filamentous fungal strain: The present invention relates to methods for reducing or eliminating the expression of a target gene in a filamentous fungal strain, comprising: (a) inserting into the genome of the filamentous fungal strain a double-stranded transcribable nucleic acid construct comprising a first nucleotide sequence comprising a promoter operably linked to a... Agent: Novozymes, Inc.

20140287476 - Vibrio cholerae 0139 conjugate vaccines: The disclosure pertains to conjugates of the capsular polysaccharide of Vibrio cholerae O139, or a structurally and/or immunologically related oligo- or poly-saccharide, and a carrier. These conjugates are useful as pharmaceutical compositions and/or vaccines to induce serum antibodies which have bactericidal (vibriocidal) activity against V. cholerae, in particular V. cholerae... Agent:

20140287477 - Variant maltohexaose-forming alpha-amylase variants: Disclosed are compositions and methods relating to variant maltohexaose-forming alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.... Agent: Danisco US Inc.

20140287478 - Novel glucose dehydrogenase: An object of the present invention is to provide a novel glucose dehydrogenase, a method for producing the glucose dehydrogenase, and applications of the glucose dehydrogenase. An isolated flavin-binding glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 80% or more identity to the amino acid sequence of... Agent:

20140287479 - Modified lecithin-cholesterol acyltransferase enzymes: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.... Agent: Amgen Inc.

20140287480 - Hbv polymerase mutants: The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase activity and fusion proteins comprising such polymerase mutant polypeptide. The present invention also relates to a nucleic acid molecule and an expression vector for expressing said polymerase mutant polypeptide as... Agent: Transgene S.a.

20140287481 - Savinase variants having an improved wash performance on egg stains: Subtilase variants having an improved wash performance on egg stains. These subtilases are useful exhibiting excellent or improved wash performance on egg stains when used in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.... Agent: Novozymes A/s

20140287482 - Method and apparatus for aseptic transfer of biological material: The present application discloses a novel biological material transfer apparatus and methods of using the same. The apparatus is made up of double walled barrel shaped tip chamber to house either the single tip or multiple tips of fixed size and a unique ball head to transfer the biological material... Agent: King Abdulaziz City For Science And Technology (kacst)

20140287483 - Methods for producing semiconductor nanoparticles: New semiconductor nanoparticles and manufacturing technologies, including novel methods, systems, and compositions, are provided herein. Robust, reproducible production of large amounts of semiconductor nanoparticles, such as quantum dots, from bacterial cultures during continuous growth is provided, without a need for extensive post growth processing or modification. The result is a... Agent: Lehigh University

20140287484 - Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof: Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions... Agent: Aemase, Inc.

20140287485 - Product and method for the removal of biofilms: Composition for the removal of biofilms present on a substrate, characterized in that it comprises at least one detergent component comprising a sequestrant and also a wetting agent and a dispersant and at least one enzymatic component containing at least one protease, at least one laccase and at least one... Agent: S.a. Realco

20140287486 - Device for analysis of a target analyte: This disclosure is directed to a slide for analyzing target analytes of a suspension. The slide can be used to collect and hold the target analyte for imaging or further processing. The slide comprises a well section, including wells into which the target analyte can be stored. The wells may... Agent: Rarecyte, Inc.

20140287487 - Device, systems and methods for analyzing a target analyte: This disclosure is directed to a cap for obtaining a target analyte from a suspension. The cap introduces a magnetic field or a magnetic gradient to the tube to draw the target analyte bound to a particle to the cap. In one aspect, a cap includes a magnetic insert and... Agent: Rarecyte, Inc.

20140287488 - Algaculture system for biofuel and neutroceutical production and methods of production thereof: An algaculture system includes a pump/tank assembly and mixer that continuously mixes and lifts a quantity of algae, nutrients, water and carbon dioxide. A solar collector that includes a plurality of interconnected tubes communicates with an outlet of the assembly. A plurality of 180 degree fittings interconnects the vertically-oriented tubes... Agent:

20140287489 - Micro-incubation systems for microfluidic cell culture and methods: A micro-incubator manifold for improved microfluidic configurations and systems and methods of manufacture and operation for a manifold and automated microfluidic systems.... Agent: Emd Millipore Corporation

20140287491 - Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended sirna: The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured.... Agent: University Of Massachusetts

20140287490 - Methods and compositions for generating an immune response by inducing cd40 and pattern recognition receptors and adaptors thereof: Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity. Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing CD40 activity without prostaglandin E2. Also provided are methods for activating an... Agent: Baylor College Of Medicine

20140287494 - Mesendoderm and mesoderm cell populations: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.... Agent: Icahn School Of Medicine At Mount Sinai

20140287493 - Method and device for performing biopsies on a vesicular object: A device for removing material from a vesicular object, said device being a pipette having a sealed tip at its distal end and an aperture whereby the distal tip of the device is inserted into the target object, the aperture aligned with the material to be removed from the object,... Agent:

20140287492 - Rna interference suppression of neurodegenerative diseases and methods of use thereof: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.... Agent: University Of Iowa Research Foundation

20140287495 - Methods of inducing differentiation of stem cells: The present invention relates to methods of inducing differentiation of stem cells. In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. The invention also includes cells, cell lines, testing models and culture systems used in the methods of... Agent: Es Cell International Pte Ltd

20140287496 - Heat-resistant newcastle disease virus live vaccine vector system and use thereof: A heat-resistant NDV live vaccine vector system includes a transcription plasmid, three helper plasmids, and host cells. The transcription plasmid is constructed by through cloning complete genomic cDNA of a heat-resistant NDV vaccine strain to a pBR322 vector. The three helper plasmids are constructed by cloning sequences coding nucleoprotein (NP),... Agent:

20140287497 - Methods of modulating cold sensory perception: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods... Agent: The Regents Of The University Of California

20140287500 - Compositions for linking zinc finger modules: Disclosed herein are compositions for linking DNA binding modules to allow for specific and selective binding to module subsites separated by 1 or more base pairs. Also described are methods of making and using compositions comprising these linkers.... Agent:

20140287499 - Ligands for the glp-1 receptor and methods for discovery thereof: Disclosed is the three-dimensional (3-D) structure of the GLP-1 receptor (GLP-1R) and methods by which the structure may be used to develop compounds that bind to, and/or modulate the GLP-1R. The technology described herein may be applied to the development of compounds that target the GLP-1R, or may be used... Agent: Transtech Pharma, LLC

20140287498 - Simplified methods for generating endothelial cells from human pluripotent stem cells under defined conditions: Methods for generating human endothelial cells from human pluripotent stem cells under defined conditions in the absence of VEGF are described. Wnt/β-catenin signaling is activated in human pluripotent stem cells for a defined period, e.g., by inhibition of Gsk3, and then cultured without further exogenous activation of Wnt/β-catenin signaling to... Agent: Wisconsin Alumni Research Foundation

20140287501 - Human disc tissue: This invention provides disc stem cells, processes for obtaining and culturing disc stem cells, and methods for repairing damaged or diseased disc tissue comprising the use of the disc stem cells of the invention.... Agent: Discgenics

20140287502 - Method for producing cell concentrate: The present invention provides a method that allows the preparation of a cell concentrate in a short time without loss of cells and great damage on cells by simple operations. The present invention provides a method for producing a cell concentrate using an inside-out filtration system for processing a cell... Agent: Kaneka Corporation

20140287503 - Use of inhibitors of leukotriene b4 receptor blt2 for treating asthma: The present invention relates to the use of inhibitors of leukotriene B4 receptor BLT2 for treating asthma. More particularly, the present invention relates to a pharmaceutical composition for treating asthma comprising BLT2 inhibitors and a method for treating asthma using BLT2 inhibitors.... Agent: Korea University Research & Business Foundation

20140287504 - Endodermal cells from pluripotent cells: The present inventions describes a method that, starting from pluripotent cells, leads to the obtainment, in a reproducible and efficient manner, of endodermal cells precursor. These cells reveal useful also for application in the regenerative therapy.... Agent:

20140287505 - Peptide-presenting surfaces for long-term culture of pluripotent cells: The present invention relates to methods of growing and maintaining pluripotent cells on an insoluble substrate that presents a peptide that binds to glycosaminoglycans, such as heparin. Specifically, methods of growing and maintaining pluripotent cells on substrates having a chemically defined surface presenting at least one peptide having basic amino... Agent:

20140287506 - Defined cell culturing surfaces and methods of use: a cell culture surface having a film attached thereto, wherein the film includes one or more plasma polymerized monomers; and a coating on the film-coated surface, the coating deposited from a coating solution comprising one or more extracellular matrix proteins and an aqueous solvent, where the total extracellular matrix protein... Agent: Corning Incorporated

20140287507 - Incorporation of plant virus particles and polymers as 2d and 3d scaffolds to manipulate cellular behaviors: Methods are generally disclosed for attaching a cell binding motif to a carboxy end of a coat protein of a Tobacco Mosaic Virus particle to form a modified-TMV particle; and attaching a cell to the cell binding motif of the modified-TMV particle.... Agent:

20140287508 - Method for applications of nano-sized materials as cell growth regulators / cell growth enhancers for plant, and agent including nano-sized materials: One aspect of the disclosure is directed to a method for activation/enhancement of cell growth of a plant. The method includes providing a nano-sized material contained agent, and treating the plant with the nano-sized material contained agent to allow sufficient interaction of cells of the plant with the nano-sized material... Agent: Board Of Trustees Of The University Of Arkansas

20140287509 - Intracellular delivery: A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function... Agent: Massachusetts Institute Of Technology

20140287510 - Rod cell-specific promoter: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 200 bp having at least 70% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically... Agent: Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute

20140287512 - Method of cultivating cells on microcarriers in a bag: e

20140287511 - Use of zscan4 and zscan4-dependent genes for direct reprogramming of somatic cells: Disclosed herein is the finding that Zscan4 is an early embryonic factor that facilitates cellular reprogramming. In particular, Zscan4 can replace the oncogenic reprogramming factor c-Myc to produce induced pluripotent stem cells when co-expressed with Klf4, Oct4 and Sox2. In addition, several Zscan4-dependent genes were identified that promote iPSC formation... Agent:

20140287513 - Trichoplusia ni piggybac transposases with reduced integration activity: The present invention is directed to nucleic acid and amino acid sequences of a novel piggyBac transposase enzymes created by modifying the transposase of Trichoplusia ni. The piggyBac transposases of the present invention are functionally active or hyperactive for excision and have decreased integration activity compared to wild type Trichoplusia... Agent: The Johns Hopkins University

  
  
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