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Chemistry: molecular biology and microbiology

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
01/22/2015 > 128 patent applications in 73 patent subcategories.

20150024374 - Gas exchanger and artificial lung: Blood or other fluids can be caused to interact with a gas by providing a plurality of fluid flow channels that are surrounded by nanotubes, each of the channels having an inflow end and an outflow end, wherein each of the channels is wide enough for the blood to flow... Agent:

20150024373 - Microfluidic chip: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the... Agent:

20150024375 - Reflex testing of samples using residual materials from a prior test: Embodiments disclosed herein relate to methods and systems for performing automated assays, and particularly to performing sequential assays on a sample on an automated instrument.... Agent:

20150024378 - Analysis of dna-containing samples and resolution of mixed contributor dna samples: Methods for analyzing DNA-containing samples are provided. The methods can comprise isolating a single genomic equivalent of DNA from the DNA-containing sample to provide a single isolated DNA molecule. The single isolated DNA molecule can be subjected to amplification conditions in the presence of one or more sets of unique... Agent:

20150024377 - Apparatus comprising magnetically actuated valves and uses thereof: The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In... Agent: Sandia Corporation

20150024382 - Assay methods for mdv-1: A method for the quantification of a vaccine strain and/or a virulent strain of Marek's Disease Virus Serotype-1 (MDV-1) in a sample from a bird, comprising the steps of: (i) providing a biological sample from the bird and optionally isolating nucleic acid from the biological sample; (ii) subjecting the biological... Agent:

20150024383 - Assay methods for mdv-1: A method for the quantification of a vaccine strain and/or a virulent strain of Marek's Disease Virus Serotype-1 (MDV-1) in a sample from a bird, comprising the steps of: (i) providing a biological sample from the bird and optionally isolating nucleic acid from the biological sample; (ii) subjecting the biological... Agent:

20150024381 - Detecting and quantifying cryptic hiv replication: The present invention relates to a novel method for detecting efficient cryptic HIV replication in a patient who receives a suppressive antiviral therapy followed by administration of the HIV integrase inhibitor in an effective amount for intensifying the suppressive antiviral therapy, and has undetectable plasma viremia prior to the administration... Agent: University Of Delaware

20150024379 - Fiber sampler for recovery of bioaerosols and particles: An aerosol collection system and method. The system includes a bio-aerosol delivery device configured to supply bioparticles in a gas stream, a moisture exchange device including a partition member coupled to the gas stream and configured to humidify or dehumidify the bioparticles in the gas stream, and an aerosol collection... Agent: Aerosol Dynamics Inc.

20150024380 - Interfering peptides and method for detecting microorganisms: The invention relates to novel interfering peptides having peptide sequence S with between 7 and 12 amino acids, originating from the peptide sequence of an antigenic protein of a micro-organism M, the sequence S being aligned with a peptide sequence S′ with between 7 and 12 amino acids originating from... Agent:

20150024376 - Trap and flow system and process for capture of target analytes: A magnetizable trap and flow system and process are detailed that uniformly disperse paramagnetic or superparamagnetic analyte capture beads within a scaffold of magnetizable beads or other magnetizable materials in a capture zone that provides selective capture of target analytes. A magnet placed or energized in proximity to the trap... Agent: Battelle Memorial Institute

20150024385 - Prediction of fertility in males: A method for evaluating sperm fertility. The method includes the steps of obtaining a sample of sperm from an animal of a species; staining the sample with a fluorescent DNA-binding dye; collecting at least one image of the stained sample; determining an edge of a nucleus of at least one... Agent:

20150024384 - Sequential delivery device and method: A reagent delivery device includes a reagent delivery column with a housing receiving reagent storage elements that can move, and a breaching element coupled to the housing. The device includes an actuation member that during operation forces the reagent storage elements toward the breaching element. Breaching the storage elements releases... Agent:

20150024396 - Brassica ahas genes and gene alleles that provide resistance to imidazolinone herbicides: Plants, plant parts and plant seeds that are resistant to imidazolinone herbicides are provided. Plants are disclosed that contain a mutation in an AHAS gene. Specifically, plants are disclosed that contain a mutant AHAS gene allele of the Brassica juncea B genome. Two B. juncea AHAS gene sequences (BjAHAS-a and... Agent:

20150024391 - Compositions and methods for detecting allogeneic matter in a subject: The present disclosure provides a panel of nucleic acid molecule primers specific for HLA-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious... Agent:

20150024388 - Expression of sep-like genes for identifying and controlling palm plant shell phenotypes: Methods and compositions are provided for optimizing fruit morphology.... Agent:

20150024390 - Method and kit for detecting specific single nucleotide polymorphism associated with ankylosing spondylitis: Disclosed is a nucleotide fragment of pathogenic single nucleotide polymorphism associated with ankylosing spondylitis with genome-wide correlation analysis of the ankylosing spondylitis patient and healthy control population in large sample by an intensive genome-wide SNP chip, the nucleotide fragment being located at the site of rs17095830, wherein for the ankylosing... Agent:

20150024386 - Method and rapid test for the detection of specific nucleic acid sequences: A universally usable method for specific detection of target nucleic acid sequences, which method can be performed very rapidly and also simply and furthermore which does not need any expensive instrumental systems. The method is intended to be suitable as a molecular genetic rapid test and to respect the requirements... Agent: Aj Innuscreen Gmbh

20150024393 - Method and system for automated image analysis in cancer cells: A method of screening for the presence and/or extent of a pathology in a subject, the pathology characterized by an abnormal chromosomal component in a cell of the subject, comprising the steps of: contacting a biological sample comprising cell nuclei from said subject with, one or more distinguishable labeled probes... Agent: Neodiagnostix Inc

20150024394 - Method and system for automated image analysis in cancer cells: A method of screening for the presence and/or extent of a pathology in a subject, the pathology characterized by an abnormal chromosomal component in a cell of the subject, comprising the steps of: contacting a biological sample comprising cell nuclei from said subject with, one or more distinguishable labeled probes... Agent: Neodiagnostix, Inc.

20150024395 - Method and system for automated image analysis in cancer cells: A method of screening for the presence and/or extent of a pathology in a subject, the pathology characterized by an abnormal chromosomal component in a cell of the subject, comprising the steps of: contacting a biological sample comprising cell nuclei from said subject with, one or more distinguishable labeled probes... Agent:

20150024389 - Method for detecting bladder cancer cells, primer used in method for detecting bladder cancer cells, and bladder cancer marker: Provided are: a method for detecting bladder cancer with high detection sensitivity, which has a high specificity for bladder cancer and is capable of detecting bladder cancer tissues with low grade of malignancy; and a bladder cancer marker. A method for detecting bladder cancer cells, which comprises detection of the... Agent: Lsip, LLC

20150024392 - Method for producing a biosensor: An object of the present invention is to provide a biosensor comprising a hydrogel capable of immobilizing a physiologically active substance thereon, which can be produced conveniently by use of a safe material, and a method for producing the same. The present invention provides a method for producing a biosensor,... Agent: Fujifilm Corporation

20150024387 - Methods for the reduction of stutter in microsatellite amplification: The invention provides a method for reducing stutter in the amplification of a microsatellite comprising the steps of providing a sample comprising a microsatellite having a G+C content of 50% or less; contacting the sample with at least one enzyme having nucleic acid polymerase activity; and incubating the sample with... Agent:

20150024398 - Analysis of genetic biomarkers for forensic analysis and fingerprinting: The present invention relates generally to methods of determining base compositions for PCR products (e.g., RT PCR products, (rt) RT-PCR products, etc.). In particular, the present invention provides base-composition determination of PCR products containing up to five different nucleobases (e.g., A, C, G, T, U) and/or significant levels of non-templated... Agent: Ibis Biosciences, Inc.

20150024401 - Analyzer: An object of the present invention relates to providing a nucleic acid analyzer capable of testing a plurality of test items in parallel, and of obtaining high efficiency of specimen processing even if the test item or a measuring object is changed. The present invention relates to an analyzer including... Agent:

20150024399 - Molecular diagnosis and typing of lung cancer variants: Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. The expression of the gene or biomarker is indicative of the lung tumor subtype. The compositions include subsets of genes... Agent:

20150024397 - Monitoring recombinase polymerase amplification mixtures: A process includes providing a mixture that includes a recombinase, a single-strand binding protein, and one or more oligonucleotides; and detecting particles in the reaction mixture.... Agent: Alere San Diego, Inc.

20150024400 - Sample collection devices, kits and methods of use: Devices, methods, and kits are disclosed for collection, labeling and analysis of samples containing a substance of interest. Such devices and methods are used in forensic, human identification, access and importation control, and other investigative technologies to collect even limited amounts of a substance of interest that may be present... Agent:

20150024402 - Method and kit for measuring interaction between molecules: The present invention relates to methods of measuring interaction between a first and a second molecule, for example a protein and an antibody, by conjugation of one of these molecules with nanoparticles, and measuring the interaction between the first and second molecule via changes in the optical properties of the... Agent:

20150024406 - Increased aquaporin expression on cellular membrane to improve cryopreservation efficiency: A method of storing mammalian cells or tissue (e.g., liver cells or hepatocytes) for subsequent use comprises the steps of: (a) contacting the cells or tissue in vitro to a choleretic agent in an effective amount; (b) combining said cells or tissue with a cryopreservative; (c) freezing said cells or... Agent:

20150024407 - T1r hetero-oligomeric taste receptors: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are... Agent:

20150024408 - Water soluble nanocrystalline quantum dots capable of near infrared emissions: A novel quantum dot capable of near infrared emissions at wavelengths of 750-1100 is made by forming solid solutions of metal sulfide, metal selenide or metal sulfide selenide by incorporating a suitable amount of an additional metallic element or elements to provide an emission wavelength in the range of 750... Agent: Drexel University

20150024409 - Methods and systems for predicting drug-response: Disclosed herein are methods and systems for determining whether a cell is resistant to one or more drugs. Also, disclosed herein are methods and systems for monitoring the treatment of a cancer patient to determine whether the cancerous cells being treated are resistant to the treatment. Further, disclosed herein are... Agent:

20150024411 - Chromatographic isolation of cells and other complex biological materials: The present invention relates to the chromatographic isolation of a target cell or another complex biological material, in particular by column chromatography such as affinity chromatography or gel permeation chromatography. The invention employs a receptor binding reagent that binds to a receptor molecule that is located on the surface of... Agent:

20150024412 - Humanized fcgammar mice: Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low... Agent:

20150024410 - Method for determining the glycosylation of an antibody: The invention relates to a method for detecting the binding of an antibody to an Fc receptor present on the surface of a cell as well as to a method for determining the level of glycosylation of an antibody. The invention also relates to a reagent kit for carrying out... Agent: Cisbio Bioassays

20150024413 - Biomarkers of oxidative stress: The present invention relates to a method for detecting cardiovascular oxidative stress in an individual, comprising detecting in a blood sample from the individual modification of a cysteine at position 45 of the β1-subunit of the human erythrocyte ATP-dependent Na+K+ pump protein or of an equivalent cysteine in a homologue... Agent: Northern Sydney Local Health District

20150024414 - Amplification of biological targets via on-chip culture for biosensing: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded... Agent: Sandia Corporation

20150024403 - Method for detecting replication or colonization of a biological therapeutic: Methods for detecting replication in or colonization of a host by a biological therapeutic, such as an oncolytic virus, cells administered for cell therapy and gene therapy vectors, are provided. In the methods, a product produced by the biological therapeutic is detected in a sample of tissue or body fluid... Agent:

20150024415 - Detection and quantification of analytes based on signal induced by alkaline phosphate: A general methodology for highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method and sensors take advantage of the ability of alkaline phosphatase (ALP) to convert glucose-1-phosphate to glucose,... Agent: The Board Of Trustees Of The University Of Illinois

20150024404 - Assays for the detection of anti-tnf drugs and autoantibodies: The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against... Agent:

20150024405 - Enhanced deposition of chromogens utilizing pyrimidine analogs: where R1, R2, R3, and R4 are independently selected from aliphatic, aryl, halogen, a heteroatom-containing moiety, and hydrogen; R1 and/or R3 can be bound to R2 to form a fused, aromatic ring system; R5 is selected from a heteroatom-containing moiety; A is selected from, a carbon atom, a heteroatom, other... Agent: Ventana Medical Systems, Inc.

20150024416 - Correction method for estimating free light chain production: The invention provides a method of estimating free light chain production (FLC) in a subject comprising (i) determining an amount of FLC in a sample from the subject; and (ii) correcting the amount of FLC in the sample for FLC cleared from the source of the sample by glomerular filtration... Agent: The Binding Site Group Limited

20150024420 - Extracellular and membrane-associated prostate cancer markers: This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring... Agent: Mayo Foundation For Medical Education And Research

20150024418 - Method for diagnosing or prediagnosing a beta-amyloidopathy or an alpha-synucleopathy: The invention relates to a method for the diagnosis or prediagnosis of a β-amyloidopathy or an α-synucleopathy accompanied by a cerebral protein deposit and a reduced activity of the cerebral ABCC1-transporter, or for determining the risk of a proband suffering from such an illness, the proband already having accumulated substances... Agent:

20150024419 - Method for the assay of synucleins: The present invention provides a method for the assay of synucleins in a body fluid or tissue sample, wherein said method comprises the steps of contacting said sample with membrane lipids under conditions enabling binding of the synuclein to said lipids, and the detection of the lipid-bound synuclein by a... Agent:

20150024417 - Peptides, devices, and methods for the detection of ehrlichia antibodies: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions... Agent:

20150024421 - Number of il4 and/or il13 secreting t-cells as a biomarker for allergic diseases: The present invention relates to an in vitro use of a number of IL-4 and/or IL-13 secreting T-cells as a biomarker for diagnosing and/or monitoring an IgE-dependent allergic disease.... Agent:

20150024422 - Method of determination of risk of 2 hour blood glucose equal to or greater than 140 mg/dl: This invention relates to methods for predicting likelihood of a subject having abnormal glucose tolerance based on analyzing a combination of three or more biomarkers relating to specific physiological processes. This invention also relates to methods of accessing insulin sensitivity in a subject based on analyzing a combination of three... Agent:

20150024423 - Programmed surface enhanced spectroscopy particles: Embodiments include types of programmable surface-enhanced spectroscopy (SES) particles (PSPs), including PSP 200 having a SES-active surface 202 and a programmable reporter 206 associated with the SES surface 202 and methods of fabricating and using same. The programmable reporter 206 provides that the PSP 200 will return a controlled but... Agent:

20150024425 - Apparatuses and methods for forming wounds in cell layers: In one embodiment, an apparatus for forming wounds in cell layers includes a base that includes a guide track, and a sliding member adapted to fit within the guide track, the sliding member including a scratching element holder adapted to secure a scratching element in a position in which it... Agent: Board Of Regents, The University Of Texas System

20150024426 - Blood cell counting device and method: A device for use in imaging a liquid sample comprises an inlet for accepting the sample, a connection conduit and a detection chamber for detection of the sample, preferably optical detection of the sample. The connection conduit connects the inlet to the detection chamber and contains one or more dry... Agent:

20150024424 - Engineered living tissue substitute: The present invention relates generally to the field of tissue engineering and in particular to the production of tissue films or cell matrices, which can be used as a living tissue substitute or an artificial tissue construct in tissue repair or replacement.... Agent: National University Of Ireland, Galway

20150024427 - Solution and method for adhering suspension components to a substrate: This disclosure is directed to a method and an attachment solution for adhering a cytological or histological sample, such as buffy coat, to a substrate, such as a microscope slide. The attachment solution includes an attachment base and an anti-coagulant. The attachment base may be an alcohol, an acid, an... Agent: Rarecyte, Inc.

20150024428 - Method of identification of spore-forming bacillus spp. by direct in-situ analysis of maldi-tof mass spectrometry, and analysis system: A method of the identification of Bacillus species by direct in-situ analysis of MALDI-TOF MS (Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectometry) in which spore-forming bacteria are applied intact without any pretreatment, and an analysis system of distinctive biomarkers which allow Bacillus spores to be distinguished. Rapid and accurate detection and... Agent: Agency For Defense Development

20150024429 - Method and device for the homogeneous distribution of suspended cell components: A method for the homogeneous distribution of cell components suspended in a liquid on a surface and a device for the implementation thereof.... Agent:

20150024430 - Method for producing milk protein nanoparticles: The disclosure relates to milk protein nanoparticles produced according to a polymerization method in which at least one protein, which is obtained from milk and which can be thermally plasticized, is plasticized using a plasticizing agent, such as for example, water or glycerol at temperatures between room temperature and 140°... Agent:

20150024431 - Thrombopoietic compounds: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.... Agent: Amgen Inc.

20150024433 - Humanized antibodies that recognize alpha-synuclein: The present application discloses humanized 1H7 antibodies. The antibodies bind to human alpha synuclein and can be used for treatment and diagnosis of Lewy body disease.... Agent: Neotope Biosciences Limited

20150024434 - Method for obtaining fab fragments from single antibody producing cells by multiplexed cpr in combination with taqman probes: Herein is reported a method for a multiplex one tube real-time reverse-transcriptase gene-specific polymerase chain reaction for the amplification and quantification of cognate IgG heavy and light chains encoding nucleic acids (human IgG isotype) from a single cell.... Agent:

20150024432 - Methods for identifying immunobinders of cell-surface antigens: The invention provides methods for identifying immunobinders, such as scFv antibodies, capable of specifically binding to cell surface antigens, and compositions identified according to said methods.... Agent: Esbatech, An Alcon Biomedical Research Unit LLC

20150024435 - Mutated t7 rna polymerases: The present invention pertains to a mutated T7 RNA polymerase and its use, the T7 RNA polymerase being mutated at position 744, the glutamine (Q) being replaced by an amino acid selected from arginine (Q744R), leucine (Q744L) or proline (Q744P).... Agent:

20150024436 - Sample preparation, processing and analysis systems: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic... Agent: Integenx Inc,

20150024437 - Maltitol enriched products: The present invention relates to a process for producing a syrup which is rich in maltitol. The process is comprising the successive steps of liquefaction of a starch milk and saccharification of the liquefied starch milk in the presence of alpha-amylase, beta-amylase and a debranching enzyme selected from the group... Agent: Cargill, Incorporated

20150024438 - Heterologous expression of termite cellulases in yeast: The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast Saccharomyces cerevisiae. The cellulases can also be co-expressed in host cells with other cellulases. The expression in such host cells... Agent: Mascoma Corporation

20150024439 - Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent:

20150024440 - Microorganisms for the production of melatonin: Recombinant microbial cells and methods for producing melatonin and related compounds using such cells are described. More specifically, the recombinant microbial cell may comprise exogenous genes encoding one or more of an L-tryptophan hydroxylase, a 5-hydroxy-L-tryptophan decarboxylyase, a serotonin acetyltransferase, an acetylserotonin O-methyltransferase; an L-tryptophan decarboxy-lyase, and a tryptamine-5-hydroxylase, and... Agent:

20150024442 - Modified diacylglycerol acyltransferase proteins and methods of use thereof: Provided are fusion proteins of diacylglycerol acyltransferase (DGAT) polypeptides fused to at least one heterologous intracellular localization domain, such as a bacterial membrane-targeting domain, modified photosynthetic microorganism that comprise such fusion proteins, and related methods for improving the production of lipids by photosynthetic microorganisms, including lipids such as triglycerides, fatty... Agent: Matrix Genetics, LLC

20150024441 - Peroxisome biogenesis factor protein (pex) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms: Methods of increasing the amount of polyunsaturated fatty acids (PUFAs) in the total lipid fraction and in the oil fraction of PUFA-producing, oleaginous eukaryotes, accomplished by modifying the activity of peroxisome biogenesis factor (Pex) proteins. Disruptions of a chromosomal Pex3 gene, Pex10p gene or Pex16p gene in a PUFA-producing, oleaginous... Agent:

20150024443 - Process for the preparation of ingenol-3-angelate: The invention relates to methods for preparing ingenol-3-angelate from ingenol or ingenol derivatives.... Agent:

20150024445 - Method of producing chemical substance: A method of producing a chemical product by continuous fermentation includes filtering a culture liquid of a microorganism(s) through a separation membrane; retaining unfiltered liquid in, or refluxing unfiltered liquid to, the culture liquid; adding a fermentation feedstock to the culture liquid; and recovering a product in the filtrate, wherein... Agent:

20150024444 - Yeast cell with inactivated nadh dehydrogenase and method of producing lactate using the yeast cell: Provided are a yeast cell in which the activity of an external mitochondrial NADH dehydrogenase is decreased and a method of producing lactate by using the yeast cell.... Agent:

20150024446 - Methods for improving malic acid production in filamentous fungi: The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous... Agent:

20150024447 - Butyraldehyde dehydrogenase mutant, polynucleotide encoding the mutant, vector and microorganism having the polynucleotide, and method of producing 1,4-butanediol using the same: A mutant butyraldehyde dehydrogenase (Bld), a polynucleotide having a nucleotide encoding the mutant, a vector including the polynucleotide, a microorganism including a nucleotide encoding the mutant, and a method of producing 1,4-butanediol using the same.... Agent:

20150024448 - Integrated processes for the conversion of coal to chemicals: Integrated processes are disclosed for the conversion of coal containing mercury compounds, hydrocarbon-containing compounds, sulfur-containing compounds and nitrogen-containing compounds to chemicals in which coal is heated to remove mercury components, pyrolyzed to remove sulfur-containing and nitrogen-containing compounds and then gasified to provide syngas, and syngas is bioconverted to liquid product.... Agent:

20150024449 - Process and medium for reducing selenium levels in biomass from fermentation of co-containing gaseous substrates: A process for fermenting syngas and a fermentation medium provides high ethanol productivity while removing medium components that were previously thought to be essential. The process is effective for providing a specific STY of at least about 1 gram of ethanol/(L·day·gram cells) and for providing a selenium content in cell... Agent: Ineos Bio Sa

20150024450 - Gene knockout mesophilic and thermophilic organisms, and methods of use thereof: One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt... Agent: Mascoma Corporation

20150024451 - Protein recovery: A process for recovering a protein-containing fermentation agent, comprising (i) forming an aqueous mixture of an organic material and a protein-containing fermentation agent capable of fermenting the organic material to produce ethanol, (ii) fermenting the aqueous mixture to produce ethanol, (iii) recovering from the fermented aqueous mixture an ethanol stream... Agent:

20150024452 - Exhaust scrubber: Provided herein are methods, devices and systems for decreasing emissions in exhaust comprising contacting the exhaust with a liquid waste stream from a biogas production unit, the liquid waste stream being contacted with the exhaust, optionally, in a plurality absorbers operatively connected in-line and/or in parallel.... Agent:

20150024453 - Integrated process for dual biocatalytic conversion of co2 gas into bio-products by enzyme enhanced hydration and biological culture: A method, process, apparatus, use and formulation for dual biocatalytic conversion of CO2 containing gas into carbon containing bio-products by enzymatic hydration of CO2 into bicarbonate ions in the presence of carbonic anhydrase and metabolic conversion of the bicarbonate ions into carbon containing bio-products in a biological culture. The dual... Agent:

20150024454 - Oil absorption and bioremediation apparatus employing oil digesting microorganisms: An absorbent material may include banana tree stalk fibers separated and processed for moisture content reduction to generate processed fibers, and oil eating microorganisms (OEMs) infused into the processed fibers to form OEM infused fibers. The processed fibers may be configured to concentrate oil therein responsive to exposure to the... Agent:

20150024457 - Antibodies to troponin i and methods of use thereof: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.... Agent:

20150024456 - Compounds and methods for use in detecting gabapentin: Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce gabapentin conjugates. A gabapentin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-gabapentin antibody. A gabapentin-detectable label may be used in a... Agent:

20150024458 - Dock-and-lock (dnl) complexes for therapeutic and diagnostic use: Disclosed herein are methods and compositions dock and lock (DNL) complexes comprising an AD moiety selected from an AKAP protein and a DDD moiety selected from a protein kinase A regulatory subunit. Also disclosed are fusion proteins comprising an AD moiety or DDD moiety attached to an effector moiety. The... Agent:

20150024459 - Multivalent antibody complexes targeting igf-1r show potent toxicity against solid tumors: The present invention concerns methods and compositions comprising an anti-IGF-1R antibody or fragment thereof for treatment of cancer or autoimmune disease. Preferably, the cancer is renal cell carcinoma, breast cancer or pancreatic cancer. The anti-IGF-1R antibody or fragment may be part of a complex, such as a DOCK-AND-LOCK™ (DNL™) complex.... Agent:

20150024460 - Npp1 fusion proteins: The present invention provides a novel fusion polypeptide containing a catalytic domain of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.... Agent:

20150024455 - Nucleophilic catalysts for oxime linkage: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and... Agent:

20150024461 - Mutant enzyme and application thereof: An object is to provide a novel enzyme that exhibits glucose dehydrogenase activity. Furthermore, another object is to provide a novel method pertaining to enzyme modification. Provided is a mutated enzyme containing an amino acid sequence wherein one or at least two amino acids selected from a group are substituted... Agent:

20150024462 - Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin: The present disclosure relates to improved expanded bed adsorption processes for isolating proteins from milk sources. In particular embodiments, the present disclosure provides a process for isolating a milk protein, such as lactoferrin, from a milk source comprising establishing an expanded bed adsorption column comprising a particulate matrix, applying a... Agent:

20150024463 - Modified polymerases for improved incorporation of nucleotide analogues: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly... Agent: Illumina Cambridge Limited

20150024464 - Engineered nucleases and their uses for nucleic acid assembly: Aspects of the invention provide engineered endonucleases that are characterized by both a long recognition sequence and specific cleavage outside of the recognition site. Engineered endonucleases of the invention are useful for manipulating long pieces of DNA.... Agent: Celexion, LLC

20150024465 - Carbohydrate-binding modules of a new family: The present invention relates to non-catalytic carbohydrate-binding modules (CBM) belonging to a new family of CBM's. A CBM of the invention was found attached to a glycosyl hydrolase family 61 (GH61) polypeptide and was shown to have little homology with known CBM's indicating that it is the first known member... Agent:

20150024466 - Polypeptides with xylanase activity: The present invention relates to polypeptides with xylanase activity and uses thereof. The present invention also relates to method of modifying polypeptides with xylanase activity to affect, preferably to increase, xylanase activity and/or bran solubility.... Agent:

20150024467 - Methods for purification of recombinant aav vectors: Provided herein are methods for the purification of recombinant adeno-associated virus (rAAV) vectors that can be used for gene transfer and specifically for gene therapy or vaccination. Recombinant AAV vectors of the invention are substantially free of in-process impurities, including production components such as cellular nucleic acids, cellular proteins, helper... Agent: Genzyme Corporation

20150024469 - Endolysin obpgplys: The present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO: 1 and fragments or derivatives thereof. The present invention further relates to fusion proteins comprising said polypeptide and an additional peptide stretch fused to said polypeptide at the N- or C-terminus. Moreover, the... Agent: Katholieke Universiteit Leuven, K.u. Leuven R&d

20150024468 - Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol: The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2... Agent: Genomatica, Inc.

20150024470 - Microorganism belonging to yarrowia genus, and oil decomposition agent and oil decomposition/removal method using same: The present invention addresses the problem of providing a new microorganism that is useful for efficiently decomposing oils and fats, and a use for said microorganism. According to screening results, a new Yarrowia lipolytica having a high capacity to assimilate free fatty acids was successfully obtained. Efficient decomposition of oils... Agent:

20150024471 - Enzyme catalyzed disassembly of corn kernels: Whole corn kernels or particles thereof are enzymatically disassembled. The method can produce a solid starch fraction, a solid pericarp fraction, and a liquid fraction. A high purity starch solids product can be provided suitable for use as a feedstock in other chemical processes.... Agent:

20150024472 - Biological growth monitoring and parameter extraction system: A biological growth monitoring and parameter extraction system includes a comparison group platform and an experimental group platform. First environmental sensing modules of the comparison group platform extracts first environmental parameters of a biological comparison area, a first control module transmits the parameters to the experimental group platform, and a... Agent: National Taiwan University

20150024473 - Device and method for performing blood thromboelastographic assays by magnetic sensing: A magnetic sensor elastometry device (MSED) and a method to perform the whole blood thromboelastography assay. It contains key components, including sample cuvette, detecting head, rotating disc, optical motion detector, and etc; and measures viscoelasticity of whole blood samples. The device optically monitors the physical motion of the magnetically driven... Agent:

20150024475 - Affinity capture of circulating biomarkers: Methods, devices and systems for capturing biomarkers are provided. In particular, methods, compositions, and systems that utilize affinity capture devices comprising a processing chamber, affinity capture agent and porous membrane are provided.... Agent:

20150024474 - Thermal cycler device: The present invention relates to a thermal cycler device for carrying reaction slides for assays with thermal cycling reactions. The thermal cycler device includes a conveyer with a plurality of slide holders for conveying slide plates through more than one temperature zones for thermal cycling reactions.... Agent:

20150024477 - Biosensor chip, and biosensor device equipped with same: This biosensor chip is placed in a biosensor device and is rotated while a specimen is measured, the biosensor chip comprising a main body, a holding chamber, a dispensing chamber, a plurality of quantification chambers, and a plurality of measurement chambers. The main body has an inlet into which a... Agent:

20150024476 - Cell sorting system and methods: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of... Agent:

20150024478 - One-way separator for retaining and recirculating cells: The invention relates to the use of single- or multilayer plastic web plates in a sloped channel-type solid material separator with a lamella package.... Agent: Mayer Intellectual Property Gmbh

20150024479 - Thermal cycling apparatus and method for providing thermal uniformity: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.... Agent:

20150024481 - Sample preparation devices and systems: Devices and system for preparing samples are described. Such devices can comprise fluidic chambers, reservoirs, and movable structures for controlling the movement of samples. The device can also comprise functional elements for performing specific operations.... Agent:

20150024480 - System, apparatus and method for material preparation and/or handling: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along... Agent:

20150024482 - Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer: The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is... Agent:

20150024483 - Therapeutic conditioned media: Disclosed are therapeutic compositions useful for treatment of degenerative, autoimmune, inflammatory, and neurological conditions. In one embodiment, clinical conditions are treated by administration of a standardized composition of stem cell, progenitor cell, or cellular supernatant. The invention provides doses of conditioned media that mediate therapeutic effects at concentrations that would... Agent:

20150024484 - Antibody inhibitors of gdf-8 and uses thereof: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.... Agent: Wyeth LLC

20150024485 - Puro-dhfr quadrifunctional marker and its use in protein production: This invention relates to industrial production of proteins. More specifically, the invention relates to the res-DHFR surrogate marker, which corresponds to a fusion between DHFR and a protein conferring resistance to a toxic compound or conferring a metabolic advantage. The invention further relates to the use of res-DHFR for screening... Agent:

20150024486 - Embryonic stem cell specific micrornas promote induced pluripotency: The methods of the present application describe that introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells). These miRNAs did not further enhance reprogramming in the presence of cMyc. Furthermore, unlike previously described methods of generating iPS cells, such as... Agent:

20150024487 - Cryopreservation storage device for cell collection bag, and using method thereof: The present invention relates to a cryopreservative device comprising an outer case, one or more layers of space for the cryo-bags, and two or more Teflon cryopreservative bags. The outer case has a cover lip for opening and closing. The Teflon cryopreservative bags are filled with a freezing resistant. In... Agent: Steminent Biotherapeutics, Inc.

20150024489 - Device for enhancing immunostimulatory capabilities of t-cells: T-cells are generated with enhanced immunostimulatory capabilities for use in self therapy treatment protocols, by utilizing a biodegradable device with a biodegradable support that has one or more agents that are reactive to T-cell surface moieties. The biodegradable devices are mixed with the T-cells sufficiently so that the one or... Agent:

20150024488 - Nucleic acid complex: The present invention relates to a complex comprising a cationic block copolymer and a nucleic acid, the cationic block copolymer having at least a tri-block structure comprising a cationic block and two hydrophilic blocks, or a hydrophilic block and two cationic blocks.... Agent: Commonwealth Scientific And Industrial Research Organisation

20150024490 - Chemically labile peptide-presenting surfaces for cellular self-assembly: Methods of cell culture using patterned SAM arrays are disclosed. Advantageously, the disclosed methods use SAM arrays presenting adhesion peptides to grow confluent monolayers that can invaginate to form an embryoid body.... Agent:

20150024491 - Neuronal culture medium and method for producing in vivo-like and enhanced synaptogenesis neuron model: An object of the present invention is to develop and provide a method for producing a neuron model having reproduced in vivo properties by improving a cell culture medium composition and a cell culture medium composition necessary for the production of such neuron model. According to the present invention, cell... Agent: Okinawa Institute Of Science And Technology Graduate University

20150024492 - Cell expansion system and methods of use: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits... Agent: Terumo Bct, Inc.

20150024494 - Defined cell culturing surfaces and methods of use: a cell culture surface having a film attached thereto, wherein the film includes one or more plasma polymerized monomers; and a coating on the film-coated surface, the coating deposited from a coating solution comprising one or more extracellular matrix proteins and an aqueous solvent, where the total extracellular matrix protein... Agent:

20150024493 - Method for preparing a patterned substrate and use thereof in implants for tissue engineering: A method for preparing a patterned substrate is provided. The method includes melt-spinning at least one biocompatible polymer to form fibers; collecting the fibers on a substrate such that the fibers are aligned on the substrate; and applying a binding agent to the aligned fibers to bond the fibers into... Agent:

20150024495 - Device and method for engineering living tissues: A device for assembling aggregations of adherent cells includes a gripper moveable within an assembly vessel that fixes aggregations of adherent cells at a membrane of the gripper and, by movement of the gripper, assembles aggregations of cells on a separate membrane within the vessel, thereby creating a three-dimensional assembly... Agent:

20150024496 - Methods and systems for utilizing sperm for molecular delivery: Disclosed herein include embodiments related to delivery of molecular molecules by a sperm cell to an egg cell for expression, including transient expression, in a fertilized progeny. Further embodiments relate to computerized systems for assisting in the disclosed methods.... Agent:

20150024497 - Methods and systems for utilizing sperm for molecular delivery: Disclosed herein include embodiments related to delivery of molecular molecules by a sperm cell to an egg cell for expression, including transient expression, in a fertilized progeny. Further embodiments relate to computerized systems for assisting in the disclosed methods.... Agent:

20150024498 - Cldn5 mini-promoters: Isolated polynucleotides comprising a CLDN5 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of... Agent:

20150024500 - Methods and compositions for producing double allele knock outs: The present invention provides a method and compositions utilizing the CRISPR system to disrupt a target gene in eukaryotic cells to produce double allele knock outs. The method finds use in producing afucosylated antibodies with enhanced ADCC activity.... Agent: Larix Bioscience, LLC

20150024499 - Modified cascade ribonucleoproteins and uses thereof: A clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for adaptive antiviral defence (Cascade); the Cascade protein complex comprising at least CRISPR-associated protein subunits Cas7, Cas5 and Cas6 which includes at least one subunit with an additional amino acid sequence possessing nucleic acid or chromatin modifying, visualising, transcription activating or... Agent:

  
01/15/2015 > 102 patent applications in 56 patent subcategories.

20150017627 - System for hypothermic transport of samples: A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a... Agent: Paragonix Technologies, Inc.

20150017628 - Cryopreservation of cells in absence of vitrification inducing agents: The present invention relates to a method for cryopreserving biological material. In particular, the method comprises storing the biological material at a cryopreserving temperature in a composition comprising polyvinyl alcohol (PVA). wherein the composition is substantially free of vitrification-inducing agents such as DMSO and glycerol. The invention also provides methods... Agent: University Of Warwick

20150017629 - Device and method for bacterial culture and assay: The present invention provides a simple culture device that is designed for manufacture and use in areas of limited resources. The device is useful for cell culture in such environments with limited resources because cells grow in paper just as they do in a culture dish. Also provided is a... Agent:

20150017631 - Real-time pcr detection of seasonal influenza h1, h3 and b subtypes: The present invention relates to assays, diagnostic kits and methods for the simultaneous real-time PCR detection of influenza viruses selected from influenza A, in particular subtypes H1 and/or H3, and/or influenza B.... Agent: Vela Operations Pte. Ltd

20150017630 - Signatures and determinants for diagnosing infections and methods of use thereof: Antibiotics (Abx) are the world's most misused drugs. Antibiotics misuse occurs when the drug is administered in case of a non-bacterial infection (such as a viral infection) for which it is ineffective. Overall, it is estimated that 40-70% of the worldwide Abx courses are mis-prescribed. The financial and health consequences... Agent:

20150017640 - Combinations of molecular markers in prostate cancer providing a diagnostic tool with improved sensitivity/specificity: The present invention relates to methods for in vitro establishing, or diagnosing, high grade or low grade prostate cancer in a sample, preferably from a readily obtainable sample such as an urine, a prostatic fluid or ejaculate sample or a processed, or derived sample thereof, originating from human individual suspected... Agent:

20150017632 - Complexity management of genomic dna: The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the... Agent: Affymetrix, Inc.

20150017636 - Detection and monitoring of macrocyclic lactone resistance in nematodes: The present disclosure concerns the determination of the resistance or the susceptibility of a nematode to a macrocyclic lactone anti-helminthic based on the characterization of the Dyf-7 gene (or Dyf-7 gene ortholog) or its corresponding gene products. The present disclosure also provides tools and commercial packages for making such characterization.... Agent:

20150017634 - Detection and prognosis of cervical cancer: The present invention relates to methods and kits for identifying, diagnosing, prognosing, and monitoring cervical cancer. These methods include determining the methylation status or the expression levels of particular genes, or a combination thereof.... Agent: Oncomethylome Sciences S.a.

20150017635 - Direct capture, amplification and sequencing of target dna using immobilized primers: Certain embodiments provide a method for capturing a genomic fragment. The method may comprise: obtaining a substrate comprising a first population of surface-bound oligonucleotides and a second population of surface-bound oligonucleotides; hybridizing a first member of the first population of surface-bound oligonucleotides to a selection oligonucleotide comprising a region that... Agent:

20150017641 - Mechanical washing and measuring device for performing analyses: The invention describes simple and reliable cartridge constructions for carrying out analytical procedures in a closed system, especially for carrying out bioaffinity analyses. The cartridge exploits a measuring component, or a test strip (1 in FIG. 1) and its cover (2 in FIG. 1) as well as the motion between... Agent:

20150017642 - Method for the diagnosis of myeloid neoplasias and solid tumors and diagnostic kits: b) detecting the presence or absence of a mutation in the nucleic acid sample comprising the NF-E2 gene or a fragment thereof, characterized in that the presence of the mutation is an indication of a myeloid neoplasm or solid tumor, whereby the mutation is determined by comparing the nucleic acid... Agent: Universitaetsklinikum Freiburg

20150017643 - Method of molecular typing: The invention relates to the identification of genetic traits in an individual. More specifically, the invention relates to identifying human leukocyte antigen (HLA) alleles and haplotypes in a potential donor sample. The invention can be used for matching a donor with a recipient for transplantation, other medical needs and high-through... Agent:

20150017633 - Methods and compositions to evaluate antibody treatment response: The present invention relates to methods and compositions to evaluate or assess the response of a subject to particular therapeutic treatment. More particularly, the invention provides methods to determine the response of subjects, or to adapt the treatment protocol of subjects treated with therapeutic antibodies. The invention is based on... Agent:

20150017638 - Methods for assessing risk for cancer using biomarkers: The present disclosure is directed to methods and kits for detecting, characterizing, preventing, and treating cancer, e.g., pancreatic cancer, or inflammation, by determining the presence of circulating epithelial in a biological sample and further identifying the tissue of origin using a tissue-specific biomarker, e.g., Pdx-1.... Agent: The Trustees Of The University Of Pennsylvania

20150017639 - Molecular diagnostic assay device and method of use: Lateral flow devices and methods of use for a molecular diagnostic assay are provided. The method is suitable for detection or monitoring of targets, including biological, chemical, and material targets that exist in very low concentrations in biological samples. The methods and devices of the present application are amenable to... Agent: Credo Biomedical Pte Ltd.

20150017644 - Plant transformation without selection: The invention provides methods for identifying regenerated transformed plants and differentiated transformed plant parts, obtained without subjecting plant cells to selective conditions prior to regenerating the cells to obtain differentiated tissues. In particular embodiments, the plant cells are corn plant cells. Methods for growing and handling plants, including identifying plants... Agent:

20150017645 - Qualitative and quantitative detection of microbial nucleic acids: The present invention relates to new methods and uses for the qualitative and quantitative detection of microbial nucleic acids using at least a first control nucleic acid, or a first and a second control nucleic acid in different concentrations. The method is based on amplification of nucleic acids, for example... Agent:

20150017637 - Recurrent gene fusions in cancer: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for cancer.... Agent:

20150017646 - Systems and methods for multiplex analysis of pcr in real time: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable... Agent:

20150017647 - Tissue processing apparatus: An apparatus for processing a biological sample is provided. The biological sample being arranged on a first planar surface of a carrier, the apparatus having a second planar surface arranged substantially parallel to said first planar surface and at a first distance from said first planar surface. The first planar... Agent: Dako Denmark A/s

20150017653 - Absolute pcr quantification: The present application provides methods and devices for absolute quantification of polymerase chain reaction target nucleic acids. In particular, the methods and devices of the present application provide for splitting a nucleic acid sample to be analyzed into small, isolated volumes, conducting the method of polymerase chain reaction (PCR) on... Agent: The Research Foundation For The State University Of New York

20150017654 - Absolute pcr quantification: The present application provides methods and devices for absolute quantification of polymerase chain reaction target nucleic acids. In particular, the methods and devices of the present application provide for splitting a nucleic acid sample to be analyzed into small, isolated volumes, conducting the method of polymerase chain reaction (PCR) on... Agent: The Research Foundation For The State University Of New York

20150017652 - Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions: Compositions and methods are described for standardizing the DNA amplification efficiencies of a highly heterogeneous set of oligonucleotide primers as may typically be used to amplify a heterogeneous set of DNA templates that contains rearranged lymphoid cell DNA encoding T cell receptors (TCR) or immunoglobulins (IG). The presently disclosed embodiments... Agent:

20150017649 - Compositions and methods for detecting noonan syndrome: Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in a RAS-specific guanine nucleotide exchange factor gene SOS1 or its expression product. The diagnostic and therapeutic applications are also based on certain mutations in a serine/threonine protein kinase gene RAFl... Agent: Mount Sinai School Of Medicine

20150017648 - Devices, systems and methods for thermal control of droplet detection: A droplet detection system comprises a first channel in fluid communication with a carrier fluid reservoir and a second channel in fluid communication with a sample reservoir. The first channel and second channel can meet at an intersection. The sample reservoir can include a sample or partition thereof. During use,... Agent: Bio-rad Laboratories, Inc.

20150017651 - Personalized medicine for the prediction of therapy targeting the hedgehog pathway: Methods and composition for tumor therapy, especially esophageal adenocarcinoma (EAC), are described. For example, in certain aspects methods for determining Hedgehog and mTOR signaling pathway status to select patients for administering a combination therapy of Hedgehog and mTOR signaling inhibitors are described. Furthermore, the invention provides compositions that involve testing... Agent: Board Of Regents, The University Of Texas System

20150017650 - Reagents and methods for autoligation chain reaction: The invention relates to the amplification of specific target nucleic acids. The invention provides methods, reagents, and kits for carrying out such amplification via the autoligation chain reaction (ACR).... Agent:

20150017655 - Label-free sequencing method for single nucleic acid molecule: A label-free sequencing method for a single molecular nucleic acid is provided. The primer is paired with the nucleic acid template to be assembled to a polymerase. When the nucleotides are added, the electrical conductance signal is measured by the polymerase being connected to the protein transistor to determine the... Agent: National Chiao Tung University

20150017659 - Profiling of signal pathway proteins to determine therapeutic efficacy: The present invention provides methods for detecting, measuring and quantitating the activation states of components of the PI3K signaling pathway in cells such as tumor cells. In particular embodiments, the present invention enable the determination of tumor adaptation to anticancer therapy. Accordingly, the present invention provides methods for improved cancer... Agent:

20150017663 - Identification of antitumor compounds using placenta: Provided herein are methods of evaluating potential antitumor compounds, and thereby identifying antitumor compounds, using placenta or a portion thereof and tumor cells, and compositions for accomplishing the same. In one embodiment, provided herein is a method of determining whether a potential antitumor compound is effective against a plurality of... Agent: Anthrogenesis Corporation

20150017662 - Method for detecting and quantifying a target protein or a target cell using an aptamer chip: The present invention is a method for detecting or quantifying a target cell or a target protein using an aptamer chip, and particularly, in order to detect a target cell, a method for detecting and/or quantifying a target cell by reacting a cell staining solution (e.g. 4′,6-diamidino-2-phenylindole (DAPI)) with an... Agent: University-industry Cooperation Group Fo Kyung Hee University

20150017660 - Method of exosome analysis, reagent for exosome analysis, and analyzer for exosome: The method of exosome analysis of the present invention is a method of analyzing exosome in a sample, including: an addition step of adding a first antibody that specifically binds to a first antigen contained in the exosome and a second antibody that specifically binds to a second antigen contained... Agent:

20150017661 - Methods for detecting 5t4-positive circulating tumor cells and methods of diagnosis of 5t4-positive cancer in a mammalian subject: Methods are provided for detecting 5T4-positive circulating tumor cells in a mammalian subject. Methods of diagnosing 5T4-positive cancer in a mammalian subject are provided. The methods of detection or diagnosis indicate the presence of 5T4-positive metastatic cancer or early stage 5T4-positive cancer.... Agent:

20150017656 - Rapid lateral flow assay method for detecting low quantity liquid or dry samples: This invention describes a design of a lateral flow assay device that detects dried chemicals or trice volume aqueous sample solutions, applicable for detecting body fluids and dried or liquid chemicals. The dried or aqueous samples on the sample loading area will contact with a secondary aqueous solution in described... Agent:

20150017657 - Assay and method for identifying compounds that inhibit excitotoxic signals: The invention relates to an assay for identifying compounds for the treatment of various diseases including those associated with excitotoxicity. The invention also relates to cell lines and constructs for use in an assay of the invention. The invention also relates to methods for determining whether a compound reduces excitotoxic... Agent:

20150017658 - Stain, process for staining and acquiring normalized signal: A kit includes a reference probe to react with a first sample; and an analyte probe to combine with a second sample, a marker and a spectral probe to react to form the analyte probe to combine with the second sample, the marker to react with the reference probe to... Agent:

20150017666 - Diagnostic peptides for lyme disease: The present invention relates, e.g., to a composition comprising peptides represented by SEQ ID NO:1-SEQ ID NO:28 and/or SEQ ID NO:41-SEQ ID NO:47, or active variants thereof, wherein the peptides or active variants can bind specifically to an antibody induced by a causative agent of Lyme disease (a pathogenic Borrelia),... Agent:

20150017664 - Gut flora-derived extracellular vesicles, and method for searching for a disease model, vaccine, and candidate drug and for diagnosis using the same: The present application relates to a composition including gut flora-derived extracellular vesicles, and to an animal disease model using same. In addition, the present application relates to a method for using the gut flora-derived extracellular vesicles to efficiently search for a candidate drug which may prevent or treat diseases that... Agent:

20150017667 - Means and methods for assessing liver disorders: The present invention pertains to the field of diagnostics for liver disorders and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver disorders. It also relates to a method for determining whether a compound is capable of inducing such liver disorders in... Agent: Basf Se

20150017665 - Peptides and methods for detecting mpo-anca: The present invention relates to disorder-specific epitopes recognized by myeloperoxidase-anti-neutrophil cytoplasmic autoantibodies and the use of polypeptides comprising the epitopes in methods of diagnosing and monitoring autoimmune disorders associated with the autoantibodies.... Agent: The University Of North Carolina At Chapel Hill

20150017668 - Methods and compositions for diagnosing and treating mood disorders: The present invention relates to methods of diagnosing, prognosing or treating diseases or disorders in which elevated or reduced levels of Aβ protein, including Aβ1-42 are prevalent. In particular, the present invention relates to methods of diagnosing, prognosing or treating a major or minor depressive episode/disorder attributed to elevated or... Agent: New York University

20150017670 - Methods for determining the degradation of a biomass material: The present invention relates to methods for analyzing degradation of a biomass material at a high dry weight percentage.... Agent:

20150017669 - Process and its application for improving reproducibility in maldi-tof glycan profiling of human serum: experimental procedure and application to the screening for ovarian tumors: Disclosed is that the most crucial point in the quantitative analysis of MALDI-TOF MS is to minimize quantitative variances (RSDs, relative standard deviations) of peak intensities of obtained spectrum data. The minimized RSD is translated into improved reproducibility of the data and finally leads to high accuracy of the results.... Agent:

20150017671 - Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity: This invention relates to methods for determining the activity of Lp-PLA2 in at least one sample from an animal. The invention also relates to methods for determining the inhibition of Lp-PLA2 activity in samples from animals that are administered an Lp-PLA2 inhibitor.... Agent:

20150017672 - Assays for detection of glycosaminoglycans: Disclosed herein are novel methods, assays and kits useful for the diagnosis and monitoring of subjects with mucopolysaccharidoses (MPS). The methods, assays and kits are particularly useful for detecting the presence of one or more glycosaminoglycans which correlate to MPS and its severity in a variety of biological samples.... Agent:

20150017675 - Assay for determining relative redox changes in living cells and associated devices, systems, and methods: The present disclosure provides conjugates, systems, devices, and methods for detecting cellular redox state. In one aspect, for example, a conjugate for detecting cellular redox state can include a first segment including a cell penetrating peptide conjugated to a first detection molecule, and a second segment including a cargo peptide... Agent:

20150017677 - Cancer stem cells: Cancer stem cell populations characterized by expression of CD44hi, ABCG2, β-catenin, CD117, CD133, ALDH, VLA-2, CD166, CD201, IGFR, and/or EGF1R, and methods of isolating and using the same.... Agent:

20150017676 - Capsules containing mammalian cells: A capsule containing at least one mammalian cell, includes a liquid core, and at least one external envelope totally encapsulating the liquid core at its periphery, the external envelope including at least one gelled polyelectrolyte and/or a stiffened biopolymer and being able to retain the liquid core when the capsule... Agent: Capsum

20150017673 - Compositions and methods for drug-sensitization or inhibition of a cancer cell: The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The disclosure also provides methods of administering such compositions to cancer cells to sensitize them to drugs, such as chemotherapeutics, or directly... Agent:

20150017674 - Method for differentiation of pluripotent stem cells into vascular bed cells: This application relates to a method for differentiating pluripotent stem cells (PSCs) into vascular bed cells. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into vascular bed cells based on linked steps of chemically defined medium inductions.... Agent: Hoffmann-la Roche Inc.

20150017678 - Systems, devices, and methods for separating, concentrating, and/or differentiating between cells from a cell sample: Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example,... Agent: University Of Washington Through Its Center For Commercialization

20150017679 - Thin section fabrication apparatus and method of fabricating thin section: A thin section fabrication apparatus includes an epi-imaging data acquisition unit that performs imaging by radiating epi-illumination and acquires imaging data, a diffusion imaging data acquisition unit that performs imaging by radiating diffusion illumination and acquires imaging data, an exposed shape extraction unit that extracts an exposed shape of an... Agent: Sakura Finetek Japan Co., Ltd.

20150017680 - Test apparatus for testing the microbial activity on surfaces: The present invention relates to a device comprising a sample receiving appliance, a receiving appliance for test organisms, preferably for a suspension comprising test organisms, in particular for a bacterial suspension, and a jet pump appliance, wherein the jet pump appliance is, or can be brought, into active connection with... Agent:

20150017682 - Anastomotic leakage detection through dual action catheter: Technologies are generally described for detecting the presence of anastomotic leakage in the abdominal cavity through a dual action catheter placed in the vicinity of a surgery site. A portion of the dual action catheter may be affixed around the surgery site, for example, coiled around the surgery site on... Agent:

20150017681 - Device and method for biological sample collection and inspection: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position... Agent:

20150017683 - Stacked membrane bioreactor: Scalable biomaterial-based bioreactors are described. In one embodiment, the bioreactor may comprise perforated plates stacked such that the assembled bioreactor has the necessary manifolds and chambers to transport gas and liquids to a biomaterial contained within the bioreactor, and to remove the reaction products. In another embodiment, single use bioreactors... Agent:

20150017684 - Streptococcus pyogenes antigens and corresponding dna fragments: The present invention relates to antigens more particularly antigens of Streptococcus pyogenes (also called group A Streptococcus (GAS)) bacterial pathogen which are useful as vaccine component for therapy and/or prophylaxis.... Agent:

20150017685 - Efficient production of peptides: The present invention relates to processes for the production of peptides, and the peptides produced accordingly. Peptides produced according to the invention may be produced more efficiently than peptides produced according to prior art processes. The production process of the invention may lead to advantages in yield, purity, and/or price.... Agent:

20150017686 - Methods for reducing mannosyltransferase activity in lower eukaryotes: Disclosed are methods for reducing detectable mannosylation of N-linked and O-linked oligosaccharides in lower eukaryote host cells. In particular, recombinant lower eukaryote host cells are provided in which expression of the GDP-mannose transporter encoded by the Vanadate Resistant Glycosylation 4 (VRG4) gene has been disrupted. In general, the VRG4 gene... Agent:

20150017687 - Method for obtaining a glycoprotein composition: Provided is a method for producing glycoprotein with a specific glycoform compostion. The desired glycoform profile is brought about Iby altering the culture conditions on the basis of IVCC rather than the age of the culture. Further, the method renders a high product yield.... Agent:

20150017688 - Compositions and methods for reverse transcriptase-polymerase chain reaction (rt-pcr): The present invention is directed to compositions and methods useful for the amplification of nucleic acid molecules by reverse transcriptase-polymerase chain reaction (RT-PCR). Specifically, the invention provides compositions and methods for the amplification of nucleic acid molecules in a simplified one- or two-step RT-PCR procedure using combinations of reverse transcriptase... Agent:

20150017689 - ß-glucosidase: The present invention relates to a polypeptide which has β-glucosidase activity, and which includes an amino acid sequence represented by SEQ ID NO: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by... Agent:

20150017691 - ß-glucosidase: The present invention relates to a polypeptide which has β-glucosidase activity, and which includes an amino acid sequence represented by SEQ ID NO: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by... Agent:

20150017690 - Beta-glucosidase: The present invention relates to a polypeptide which has β-glucosidase activity, and which includes an amino acid sequence represented by SEQ ID NO: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by... Agent:

20150017692 - Beta-glucosidase: The present invention relates to a polypeptide which has β-glucosidase activity, and which includes an amino acid sequence represented by SEQ ID NO: 1, a polypeptide including an amino acid sequence in which one or several amino acids are deleted, substituted, or added in the amino acid sequence represented by... Agent:

20150017693 - Auto-indicible expression system, and the use thereof for producing useful metabolites using a bacterium of the family enterobacteriaceae: The present invention describes a method for producing a useful metabolite using a bacterium of the family Enterobacteriaceae, particularly a bacterium belonging to the genus Escherichia, which has been modified to contain a gene(s) expression system including elements of the LysR-type protein-regulated transcriptional machinery modified in such a way that... Agent: Ajinomoto Co., Inc.

20150017694 - Engineered co2-fixing chemotrophic microorganisms producing carbon-based products and methods of using the same: Disclosed herein are microorganisms containing exogenous or heterologous nucleic acid sequences, wherein the microorganisms are capable of growing on gaseous carbon dioxide, gaseous hydrogen, syngas, or combinations thereof. In some embodiments the microorganisms are chemotrophic bacteria that produce or secrete at least 10% of lipid by weight. Also disclosed are... Agent: Kiverdi, Inc.

20150017695 - Ketoreductase polypeptides for the reduction of acetophenones: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent:

20150017696 - Recombinant host cells and processes for producing 1,3-butadiene through a crotonol intermediate: The present disclosure relates to recombinant host cells comprising one or more recombinant polynucleotides encoding enzymes in select pathways that provide the ability to use the cells to produce 1,3-butadiene. The present disclosure also provides methods of manufacturing the recombinant host cells, and methods for the use of the cells... Agent: Codexis, Inc. A Corporation

20150017697 - Anaerobic process for producing biogas with a high methane content by means of the biodigestion of organic waste: This invention is about a process of increased Biogas (9) production, with high methane content, in anaerobic biodigestion plants, with production of electric (11) and thermal energy. The process is based upon biotechnologies, hardware and software specifically developed for this aim. One or more Devices for the Acceleration (4) of... Agent:

20150017698 - Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate: The present disclosure relates to recombinant host cells comprising one or more recombinant polynucleotides encoding enzymes in select pathways that provide the ability to use the cells to produce 1,3-butadiene. The present disclosure also provides methods of manufacturing the recombinant host cells, and methods for the use of the cells... Agent: Codexis, Inc. A Corporation

20150017699 - Internally functionalized graphene substrates: The present invention is generally directed to internally functionalized graphene substrates, methods of making such substrates and methods of using such substrates. In one aspect, the present invention is a graphene substrate. The substrate comprises edge and non-edge regions. Organic or inorganic molecules are bound to the non-edge regions of... Agent: Nanotech Biomachines, Inc.

20150017700 - Compositions and methods comprising a lipolytic enzyme variant: The present invention provides lipolytic enzyme variants. Specifically, the present invention provides lipolytic enzyme variants having two, three, or more modifications as compared to a parent lipolytic enzyme having at least one improved property. In addition, the present invention provides compositions comprising a lipolytic enzyme variant of the invention. The... Agent:

20150017701 - Hybrid alpha-amylases: Hybrid alpha-amylases are provided that share a conserved 3D structure in whole or in part with a wild-type Termamyl-like α-amylase, e.g., a Bacillus amylase. In the hybrid, an N-terminal portion of a Termamyl-like α-amylase is replaced with sequences from an archae α-amylase. The sequence similarity between the two amylase sequences... Agent: Danisco US Inc.

20150017702 - Crystallization substrate, crystallization container, crystallization device, and crystal producing method: A crystallization substrate of the present invention includes a noble metal vapor-deposited film having an absorbance in a 500 to 1,000 nm wavelength range and formed in all or part of one surface of the substrate. The noble metal vapor-deposited film has an average thickness of 0.1 to 60 nm.... Agent:

20150017703 - Methods for increasing the infectivity of viruses: Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling... Agent:

20150017704 - Cyanobacterium sp. host cell and vector for production of chemical compounds in cyanobacterial cultures: A cyanobacterial host cell, Cyanobacterium sp., that harbors at least one recombinant gene for the production of a chemical compounds is provided, as well as vectors derived from an endogenous plasmid isolated from the cell.... Agent: Algenol Biofuels Inc.

20150017706 - Captured carbon dioxide for algaculture: Enhancing growth of algae in an algaculture facility includes contacting a growth medium with a gas including carbon dioxide, transferring some of the carbon dioxide to the growth medium to yield an enriched growth medium, and providing the enriched growth medium to the algaculture facility. The concentration of dissolved carbon... Agent:

20150017705 - Method and a system for mass-cultivating microalgae with enhanced photosynthetic efficiency: A method for cultivating photosynthetic microorganisms with optimal photosynthetic efficiency, comprising the steps of exposing the microorganisms grown in a culture tank of culture broth to light and carbon source; circulating the culture broth vertically from the bottom of the tank up to the surface of the tank to allow... Agent:

20150017707 - Storage-stable liquid dishwashing detergent containing protease and amylase: In a liquid dishwashing detergent comprising a protease and amylase, storage stability is to be improved. This is achieved through the use of a protease comprising an amino acid sequence having at least 70% identity over its total length with the amino acid sequence specified in SEQ ID NO. 1... Agent: Basf Se

20150017708 - Composition for enzymatic oil degumming: The invention relates to a composition comprising at least one phospholipid-cleaving enzyme. The invention further relates to a method for degumming raw oils using the composition according to the invention and to the use of the composition according to the invention to degum raw oils.... Agent:

20150017709 - Method for detecting the presence of a target nucleic acid sequence in a sample: A method comprises loading a sample portion into a sample chamber which comprises means for minimizing diffusion of the sample portion, subjecting the sample portion to an amplification step, and determining whether the sample portion contains at least one molecule of a target nucleic acid. If the sample portion contains... Agent: Health And Human Services, United States Of America, As Represented By The Secr

20150017710 - Apparatus for testing, assessment, and maintenance of harvested hearts for transplanting: An apparatus, a system, and methods for receiving, perfusing and maintaining and assessing excised donor heart physiological functionality, The system generally comprises an apparatus for receiving and holding an excised heart that is interconnected with: (i) a perfusate-processing system, (ii) a bidirectional perfusate pumping system, (in) flow sensors for monitoring... Agent:

20150017711 - Cell culture systems: An integrated cell culture system may include one or more cell culture vessels, manipulation apparatus, pumping apparatus, cell release apparatus, monitoring apparatus, and a control apparatus. The control apparatus may be used to monitor and control the system to facilitate effective cell culturing. The cell release apparatus may be used... Agent:

20150017712 - Mass spectrometry analysis of microorganisms in samples: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.... Agent:

20150017713 - Micro fluid dosing unit and testing device for biomaterial: A micro fluid dosing unit includes a test container containing biomaterial needing oxygen. The test container has at least one first container which contains water and at least one second container which contains a pharmacological substance, wherein the first and the second containers have a container outlet leading to the... Agent:

20150017714 - Centrifugation chamber with gas permeable membrane layers for cell cultivation: The invention is directed to a centrifuge chamber comprising a cylinder having a base plate and a cover plate, a rotational axis with at least one port for input and/or output of liquids, at least one port for input of gases and at least one layer for cell culturing, wherein... Agent: Miltenyi Biotec Gmbh

20150017715 - Cell collection device and method: A compact and efficient cell collection device and method based on biologically-derived cell rolling and a planar collection module that provides fluid recirculation and modification of shear forces to discriminate between target and non-target cells.... Agent: Celltraffix, Inc.

20150017716 - One-way separator for retaining and recirculating cells: The invention relates to a separator for retaining and recirculating cells in a continuous-flow or batch-flow type plastic bag or bottle, which can preferably be operated outside of a bioreactor. Additionally, the invention relates to a method for retaining and recirculating cells within or outside a bioreactor. The invention further... Agent:

20150017717 - Culture medium for eukaryotic cells: The invention pertains to the use of C2-C6alpha-hydroxy acids selected from L-3-phenyl lactic acid, mucic (galactaric) acid, gluconic acid, glucaric acid, glyceric acid, 2-hydroxy butyric acid, alpha-hydroxyisovaleric acid, alpha-hydroxyisocaproic acid and erythronic acid and combinations thereof, as a growth- and production promoting ingredient, in culture media for culturing eukaryotic cells.... Agent: Friesland Brands B.v.

20150017718 - Method for inducing cardiac differentiation of pluripotent stem cell: e

20150017722 - Double-stranded and single-stranded rna molecules with 5' triphosphates and their use for inducing interferon: Double-stranded and single-stranded RNA molecules, and their use in methods for inducing interferon are provided. The interferon induction provides anti-viral and other medically useful effects, such as anti-cancer effects. Also provided are methods for reducing or inhibiting interferon induction exhibited by such molecules, particularly siRNA and shRNA molecules produced in... Agent: City Of Hope

20150017721 - Method for inducing proliferation of natural killer cells by mobile nanomatrices: The present invention provides an in-vitro method for inducing proliferation of NK cells, the method comprising contacting a population of NK cells with a nanomatrix, the nanomatrix comprising a) a matrix of mobile polymer chains; and b) attached to said matrix of mobile polymer chains one or more stimulatory agents... Agent:

20150017719 - Securing apparatus and method: A securing apparatus includes a housing, a cam member, and a movable device that can be moved in a first direction to engage a first surface of the cam member to cause the cam member to move from a first position to a second position. When the cam member is... Agent:

20150017720 - Therapeutic uses of curcumin analogs for treatment of prostate cancer: This invention relates generally to methods of treating aggressive cancers, such as hormone-refractory metastatic prostate cancer, by exposing the aggressive cancer cells to curcumin analogs having the claimed structural scaffolds and side groups. The anticancer effects of curcumin are associated with its influence on numerous growth factors within the cells.... Agent:

20150017724 - Method for guiding the derivation of endothelial cells from human pluripotent stem cells employing two-dimensional, feeder-free differentiation: This invention relates, e.g., to a method for differentiating mammalian (e.g., human) pluripotent stem cells (PSCs) into endothelial cells (ECs) in vitro, by plating a single-cell suspension of PSCs onto a suitable surface such as type IV collagen and culturing the cells with VEGF after which ECs can be harvested.... Agent:

20150017723 - Process of expanding t cells: The present disclosure relates to a novel process for expanding T cells, such as autologous T cells, cell populations therefrom, pharmaceutical compositions comprising the said cell populations and use of the cells and compositions for treatment, particular the treatment or prophylaxis of virus infection and/or cancer, for example in immune... Agent:

20150017725 - Production method of polyurethane porous membrane to be used for at least one of applications of cell culture and cancer cell growth inhibition: A polyurethane porous membrane is produced by a simple method to be used for at least one of applications of cell culture and cancer cell growth inhibition. The production method of the polyurethane porous membrane to be used for at least one of the applications of cell culture and cancer... Agent:

20150017726 - Media for stem cell proliferation and induction: The present application discloses a cell culture media for growth, maintenance and induction of reversion to a less mature state of a cell comprising a MUC1* activating ligand.... Agent: Minerva Biotechnologies Corporation

20150017727 - Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues: Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.... Agent:

20150017728 - Monomer architecture of tal nuclease or zinc finger nuclease for dna modification: The present invention provides compositions and methods for targeted cleavage of cellular chromatin in a region of interest and/or homologous recombination at a predetermined site in cells. Compositions include fusion polypeptides comprising a TAL effector binding or a zinc finger domain and an I-TevI homing endonuclease cleavage domain as well... Agent:

  
01/08/2015 > 112 patent applications in 78 patent subcategories.

20150010897 - Additive solution for blood preservation: A method for the storage of red blood cells provides for mixing an additive solution with packed red blood cells to create a suspension of red blood cells. The method further provides for reducing the oxygen in the suspension of red blood cells; and storing the suspension of red blood... Agent: The Trustees Of Boston University

20150010899 - Advanced fermentation control: The present invention discloses a method of controlling the rate of carbon addition to a fermentation medium in a fed batch or a continuous fermentation medium comprising measuring the C-moles lost to carbon dioxide; measuring the C-moles added via the carbon addition; calculating the carbon dioxide feed quotient, FQ, as... Agent: Novozymes A/s

20150010898 - Methods for preparation of culture media: Methods for preparation of culture media and production of recombinant proteins described herein.... Agent: Shire Human Genetic Therapies, Inc.

20150010902 - Apparatus and method for monitoring airborne microorganisms in the atmosphere: Disclosed is an apparatus for monitoring airborne microorganisms composed of: a chassis, which has a fan for flowing the air therein from the outside at a portion thereof and of which inside is spatially segmented by partition plates for performing a plurality of steps; a perforated plate, which is disposed... Agent: Hitachi, Ltd.

20150010901 - Method for detecting polyomavirus reactivation: The invention provides methods of detection and monitoring of polyomavirus reactivation and active polyomavirus infections using a biological fluid sample. Also provided are methods of risk assessment and risk monitoring of developing a polyomavirus-associated disease.... Agent: Temple University-of The Commonwealth System Of Higher Education

20150010900 - Multiple- analyte assay device and system: Provided herein are systems and methods for performing complex chemical, physical and biological assays. In particular, provided herein are systems and methods for performing microfluidic assays.... Agent:

20150010903 - Real time diagnostic assays using an evanescence biosensor: The present invention relates to a method for the detection of a substance in an aqueous, physiological or chemical liquid using the evanescence field method, and to a diagnostic device for carrying out said method.... Agent: Davos Diagnostics Ag

20150010904 - Molecular diagnostic assay device and method of use: Lateral flow devices and methods of use for a molecular diagnostic assay are provided. The method is suitable for detection or monitoring of targets, including biological, chemical, and material targets that exist in very low concentrations in biological samples. The methods and devices of the present application are amenable to... Agent:

20150010910 - Biomarkers for age-related macular degeneration (amd): A method for identifying a risk profile for age-related macular degeneration (AMD) or choroidal neovascularisation (CNV) in a subject, comprising identifying the nucleotide at one or more of the following positions: rs2071277, rs12153855 and rs9391734, or a proxy of any of those sites, in a sample obtained from the subject.... Agent:

20150010906 - Cystic fibrosis transmembrane conductance regulator gene mutations: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further... Agent:

20150010909 - Method for correcting detection signal in isothermal nucleic acid amplification reaction: e

20150010905 - Methods for genotyping selected polymorphism: Methods for genotyping polymorphisms using a locus specific primer that is complementary to a region near a selected polymorphism are described. Methods for synthesizing pools of locus specific primers that incorporate some degenerate positions are also disclosed. A plurality of different sequence capture probes are synthesized simultaneously using degenerate oligonucleotide... Agent:

20150010907 - Serial isolation of multiple dna targets from stool: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting multiple DNA targets from human stool samples.... Agent:

20150010908 - Str genotyping by differential hybridization: In a method of deducing the number of repeat units in a selected short tandem repeat (STR) in a genomic sample, at least a single stranded target DNA generated from a genomic sample comprising a selected STR, an STR probe (P1,P1′), a reference probe (P2), and two blockers (B1,B2) are... Agent: Tecan Trading Ag

20150010911 - Device and method for amplifying target nucleic acid: A device for amplifying a target nucleic acid in a sample containing one or more target nucleic acids may include a planar fluidic assembly comprising a flow channel and an inlet, wherein the inlet is in flow communication with the flow channel and is configured to introduce sample containing one... Agent: Health And Human Services, United States Of America, As Represented By The Secr

20150010914 - Biomarkers for gastric cancer and uses thereof: The present invention provides biological markers associated with gastric cancer. In particular, the present invention provides a method of diagnosing gastric cancer (GC) in a subject, the method including: measuring an expression level of one or more proteins in the subject, wherein the one or more proteins are selected from... Agent: Adelaide Research & Innovation Pty Ltd.

20150010912 - Methods of detecting tumor cells: In one aspect, methods of detecting tumor cells are described herein. In some embodiments, a method of detecting tumor cells comprises providing a device, the device comprising a substrate surface and a plurality of first aptamer probes attached to the substrate surface. The method further comprises contacting a plurality of... Agent:

20150010913 - Monoclonal antibody for detecting exosomes: A monoclonal antibody for detecting or capturing an exosome, selected from the group consisting of a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 113 to 195 of the amino acid sequence as shown in SEQ ID NO: 1, a monoclonal antibody or antibody fragments thereof that... Agent:

20150010915 - Crystal structure of the nanr and mannac-6p complex, and uses thereof: The present invention relates to a three-dimensional structure of a complex explored by crystallization of the complex of NanR which is a key pathogenic regulatory protein of Vibrio vulnificus and ManNA6P which is a NanR regulator. Further, the present invention relates to a modified NanR protein, a polynucleotide encoding the... Agent:

20150010918 - Immunochromatographic assay with minimal reagent manipulation: The present invention provides a method for determining the presence or absence of an analyte in a sample with minimal sample preparation. The invention further provides immuno-chromatographic devices for determining the presence or absence of an analyte in a sample from which the analyte should be extracted, this device comprising... Agent:

20150010917 - Method to identify ligands for sigma-1 receptors: An assay for identifying ligands of the σ1 receptor based on a fusion protein comprising the σ1 receptor flanked by two fluorophores, so that said fluorophores are capable of producing constitutive FRET when no ligand is bound to the σ1 receptor. The fusion protein of the invention also allows the... Agent:

20150010919 - Polysiloxane substrates with highly-tunable elastic modulus: A highly tunable bioscaffold is provided, as well as a method of manufacture of the bioscaffold and methods of use of the bioscaffold, for example for drug testing, cell propagation and for optimizing growth of a cell type, for example corneal endothelial cells.... Agent:

20150010916 - Porous film microfluidic device for automatic surface plasmon resonance quantitative analysis: A porous film microfluidic device includes a sample well, a porous film support structure, including a first, second, and third port, wherein the first port is connected to the sample well, a porous film is formed over the bottom of the porous film support structure, and a glass fiber film... Agent: National Taiwan University

20150010922 - Methods of selecting retinal pigmented epithelial cells: p

20150010924 - Cd8+t-cell subsets as markers for prediction of delayed fracture healing: The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28− and CD8+CD28−/CD57+, in a sample obtained from a subject. The present invention further relates to a system... Agent:

20150010923 - Method for labeling intracellular and extracellular targets of leukocytes: The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.... Agent:

20150010920 - Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity: Embodiments of the present disclosure provide for enzyme sensors, protease sensors, methods for producing and using the enzyme and protease sensors, methods of detecting and/or measuring protease activity, methods for characterizing protease cellular activity, fusion proteins, polynucleotides, and vectors corresponding to the enzyme and protease sensors, kits, and the like.... Agent:

20150010921 - Cell death assay: The present invention relates to a method for detecting cell death using a luminescent compound; to the luminescent compounds for particular uses; to a kit comprising compounds and to a protein. The method is applicable for detecting cell death, essentially regardless of the mechanism through which cell death occurred or... Agent: Publiekrechtelijk Rechtspersoon Academisch Ziekenhuis Leiden H.o.d.n. Lumc

20150010925 - Co-translational activation of a transcription factor by porteolytic cleavage and methods of use: A method for measuring expression of autoregulatory molecules within living cells is provided. An autoregulatory molecule and marker construct is expressed in vivo, where the marker is cleaved from the construct during translation. The method comprises the expression of a construct having an autoregulatory molecule bound to a measurable expression... Agent:

20150010927 - Detecting latent tuberculosis infections: This document provides methods and materials related to identifying mammals having a LTBI. For example, methods and materials for using ELISpot assays to identify mammals (e.g., humans) having a LTBI are provided.... Agent: Mayo Foundation For Medical Education And Research

20150010928 - Means and methods for assessing an endocrine disease or disorder: The present invention pertains to the field of diagnostics for an endocrine disease or disorder and assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing an endocrine disease or disorder. It also relates to a method for determining whether a compound is capable of... Agent: Basf Se

20150010926 - Methods for predicting pregnancy outcome in a subject by hcg assay: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin... Agent: The Trustees Of Columbia University In The City Of New York

20150010929 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the... Agent:

20150010930 - Reagents, kits and methods, for detecting biological molecules by energy transfer from an activated chemiluminescent substrate to an energy acceptor dye: Reagents, kits and methods for detecting biological molecules by energy transfer from an activated chemiluminescent substrate to an energy acceptor dye such as a J-aggregated dye are described.... Agent:

20150010932 - Methods for assaying protein-protein interactions: Provided herein is an assay for interrogating transient and dynamic protein-protein interactions and for screening and characterizing agents as agonists or antagonists of protein-protein interactions. The methods can provide a single assay for simultaneously assessing the bioavailability and efficacy of a test compound for increasing or decreasing a protein-protein interaction... Agent: Salk Institute For Biological Studies

20150010931 - N-end rule protease activity indication methods and uses thereof: A cell based assay for detection for protease activity is disclosed. In the assay a cell is engineered to express a protease substrate with at least one label, preferably on its C-terminus. Cleavage of the substrate by the protease that recognizes it results in a C-terminal fragment and a N-terminal... Agent: Synaptic Research, LLC

20150010933 - Novel screening methods: The present invention includes a luciferase-based high-throughput screening assay that identifies compounds that are inhibitors of cellular metabolism. This assay is applicable to all bacterial and eukaryotic membranes.... Agent:

20150010934 - Methods for detecting risk of fatal prostate cancer using serum calcium: A method of screening for increased risk of fatal prostate cancer in a subject comprises providing a blood sample collected from the subject, and then detecting the presence or absence of an increased level of serum calcium in the sample. An increased level of serum calcium indicates the subject is... Agent:

20150010935 - Systems, apparatuses and methods for reading an amino acid sequence: Embodiments of the present disclosure relate to amino acid, modified amino acid, peptide and protein identification and sequencing, by means of, for example, electronic detection of individual amino acids or small peptides.... Agent:

20150010936 - Modified leucine dehydrogenase: The present invention provides a means and method useful for measurement of a total branched-chain amino acid concentration. Specifically, the present invention provides a modified enzyme in which at least one amino acid residue is mutated so as to improve a property of a leucine dehydrogenase which is associated with... Agent: Ajinomoto Co., Inc.

20150010937 - Eukaryotic cells with artificial endosymbionts for multimodal detection: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a... Agent:

20150010938 - Selective detection of thiols: where each bond depicted as “” is a single or double bond; R1, R3-R6 and R8 independently are hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen; R2 is an α,β-unsaturated aliphatic ester; R7 is oxygen, sulfur, hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen, or R7... Agent: Oregon State Board Of Higher Education On Behalf Of Portland State University

20150010939 - Flow cytometric systems for sterile separation of magnetically labeled sample components: Systems for sterile separation of magnetically labeled sample components and methods for using the same are provided. Embodiments of the systems include a magnetic separation device and a pliant sample container, where a portion of the pliant sample container is operatively coupled under pressure to the magnetic separation device. Also... Agent: Becton, Dickinson And Company

20150010940 - Method for the rapid determination of susceptibility or resistance of bacteria to antibiotics: A method of rapidly evaluating the susceptibility of a strain of bacteria to a cell wall synthesis inhibiting antibiotic based on an assessment of cell enlargement in response to doses of the cell wall synthesis inhibiting antibiotic which are correlated to breakpoints of bacterial susceptibility.... Agent: Abm Technologies, LLC

20150010941 - Detection of acid-producing bacteria: The disclosure provides culture devices and methods useful for detecting acid-producing bacteria in a sample. The devices include a nutrient medium and a pH indicator to detect and differentiate acid-producing microorganisms, such as lactic acid bacteria. Methods of use include detecting or enumerating acid-producing microorganisms. The methods further provide for... Agent: 3m Innovative Properties Company

20150010942 - Fixative composition for cytology, cell fixation method and its applications: e

20150010943 - Metabolic engineering of xylose-fermenting eukaryotic cells: The present invention relates to genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers on the host cell the ability to isomerize xylose to xylulose. These genetic modifications are aimed at improving the efficiency of xylose metabolism and include, e.g., reduction of... Agent:

20150010944 - Modified sak gene for the production of recombinant proteins: The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing modified SAK gene fusion protein which imparts improved stability to the heterologous protein of interest. Further the invention relates to process of purification of recombinant... Agent:

20150010945 - Methods and systems for tracking bioremediation processes: A method for expression of engineered constructs containing sequences coding for functional genes of interest in E. coli strains. Here tceA and tceB are fused to an inducible, active promoter to optimize transcription of the open reading frames, and an introduced consensus Shine-Dalgarno sequence allowing for optimal ribosome binding and... Agent: Arizona State Board Of Regents For And On Behalf Of Arizona State University

20150010946 - Polynucleotides encoding zcytor17 ligand antibodies: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing... Agent:

20150010947 - Domain swapping modules: Methods and systems for creating a genetic construct, a protein, and a polymer comprising a domain swapping module. A domain swapping module is a fusion protein in which a lever protein, which has a long amino (N) to carboxy (C) terminal distance, is inserted into a surface loop of an... Agent: The Research Foundation For The State University Of New York

20150010948 - Fermentation process: A process for fermenting Bordetella species comprising incubating a sample of bacteria of a Bordetella species in a first environment under at least one bvg (Bordetella virulence genes) modulating condition, for at least 5 generations, to produce a mature culture, and then incubating the mature culture in a second environment... Agent:

20150010949 - Carbohydrate based binder system and method of its production: The present invention relates to an aqueous carbohydrate based binder composition, comprising a carbohydrate component and an amine component, wherein the carbohydrate component comprises one or more pentose sugars, as well as to a method of its production.... Agent: Knauf Insulation

20150010951 - Method of microvesicle enrichment: The present invention relates to a method of enriching for membranous microvesicles relative to the cellular population in a biological sample. More particularly, there is provided a method for enriching for exosomes from plasma. In a related aspect, there is provided a method of reducing the concentration of cellular and... Agent: Clinical Genomics Pty. Ltd.

20150010950 - Modified rna ligase for efficient 3' modification of rna: The invention provides a novel truncated mutated T4 RNA ligase 2. In addition, methods are provided for ligating pre-adenlylated donor molecules to the 3′ hydroxyl group of RNA in the absence of ATP using the ligase.... Agent:

20150010952 - Complementing cell lines: A packaging cell line that complements recombinant adenoviruses based on serotypes from subgroup B, preferably adenovirus type 35. The cell line may be derived from primary, diploid human cells that are transformed by adenovirus E1 sequences either operatively linked on one DNA molecule or located on two separate DNA molecules,... Agent:

20150010953 - Method for producing a population of oligonucleotides that has reduced synthesis errors: Provided herein is a method for producing a population of oligonucleotides that has reduced synthesis errors. In certain embodiments, the method comprises: a) obtaining an initial population of hairpin oligonucleotide molecules that each comprise a double-stranded stem region and a loop region; b) contacting the double-stranded region of the hairpin... Agent:

20150010954 - Glucosyltransferase enzymes for production of glucan polymers: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase... Agent:

20150010955 - Glucosyltransferase enzymes for production of glucan polymers: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase... Agent:

20150010956 - Glucosyltransferase enzymes for production of glucan polymers: Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase... Agent:

20150010957 - Alkcell process (alkali-cellulase process) for the conversion of biomass (cellulosic material) to glucose: The Alkcell (alkali-cellulase) Process is a method for the conversion of biomass (cellulosic material) such as agricultural waste, for example, corn stover into glucose. The process uses an alkali pretreatment of biomass followed by hydrolysis with cellulase enzymes to produce glucose. The Alkcell Process uses commonly available materials and methods... Agent:

20150010959 - Method for producing saccharides containing glucose as main component: A method for producing saccharides containing glucose as a main component is described, including degrading cellulose and/or hemicellulose with a cellulase, wherein an additive containing a protein and an amino acid and/or a yeast lysate solution is added to the cellulose and/or hemicellulose and the cellulase is used to cause... Agent: Jgc Corporation

20150010958 - Methods for degrading or converting cellulosic material: The present invention provides methods for degrading or converting a cellulosic material using an enzyme composition in the presence of a reducing agent. The present invention also provides methods for producing a fermentation product and methods of fermenting a cellulosic material using an enzyme composition in the presence of a... Agent: Novozymes Inc.

20150010961 - Polypeptide having endoglucanase activity: The present invention relates to a family 5 glycoside hydrolase variant having endoglucanase activity, polynucleotides encoding the family 5 glycoside hydrolase variant, vectors, host cells comprising the polynucleotides, and methods for using the family 5 glycoside hydrolase variant.... Agent:

20150010960 - Soft biomass decomposition method: An object of the present invention is to provide a soft biomass decomposition method, a production method for a target substance from soft biomass, and an enzyme or group of enzymes for decomposing soft biomass. Provided is a soft biomass decomposition method, including a step of bringing an enzyme selected... Agent: National University Corporation Mie University

20150010962 - Method for producing basic substance: A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter... Agent: Ajinomoto Co., Inc.

20150010963 - Method for producing basic substance: A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter... Agent: Ajinomoto Co., Inc.

20150010964 - Method for increasing yield of total flavonoids in ganoderma lucidum mycelium: A method for increasing the yield of total flavonoids in Ganoderma lucidum mycelium by an expansin comprises: (1) inoculating Ganoderma lucidum into the PD liquid fermentation medium, activating the culturing of the strains and obtaining a seed solution; (2) inoculating the seed solution into a liquid fermentation medium, culturing and... Agent: Institute Of Agricultural Resources & Environment, Shandong Academy Of Agricultural Sciences

20150010965 - Process for the production of furan derivatives from glucose: m

20150010966 - Enzymatic process for fat and oil hydrolysis: An efficient process for enzymatic hydrolysis of fats and oils in a homogenous mixture is provided herein. The present invention in particular provides a process for production of fatty acids, sn-regio mono-acylglycerol (MAG), sn-regio di-acyl-glycerols (DAG), and glycerol from fats, wherein more than 98% fats can be converted into the... Agent: Institute Of Chemical Technology (deemed University)

20150010967 - Processing biomass: Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce a product or intermediate, e.g., energy, a food, a... Agent:

20150010968 - Biological alkene oxidation: The present invention relates to method for oxidising an alkene comprising contacting said alkene with an AlkB-type oxidoreductase in the presence of oxygen, and a use of an AlkB-type oxidoreductase, preferably AlkB from Pseudomonas putida GPO1 or a variant thereof, for oxidising an alkene to an alcohol and/or acid.... Agent: Evonik Industries Ag

20150010969 - Method for producing glucaric acid: The disclosure provides a method for creating a transformant having significantly improved glucaric acid-producing capability and a method for efficiently producing glucaric acid using the transformant.... Agent: Asahi Kasei Chemicals Corporation

20150010972 - Method for producing lactic acid: The method for producing lactic acid of the present invention includes a first fermentation step of carrying out fermentation by use of one or more fungus cells selected from the group consisting of pellet-form filamentous fungus cells and immobilized filamentous fungus cells in a liquid culture medium having a phosphate... Agent: Kao Corporation

20150010971 - Method of producing chemical substance: A method of producing a chemical product by continuous fermentation includes filtering a culture liquid of a microorganism(s) through a separation membrane; retaining unfiltered liquid in, or refluxing unfiltered liquid to, the culture liquid; adding a fermentation feedstock to the culture liquid; and recovering a product in the filtrate, wherein... Agent:

20150010970 - Methods for producing end-products from carbon substrates: The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction... Agent: Danisco US Inc.

20150010973 - Fungal strains with genetic modification relating to a carboxylic acid transporter: The invention relates to fungal strains having at least one genetic modification which leads to a reduction of the activity of at least one fungal carboxylic acid transporter and to a method for producing or using said fungal strains.... Agent: Thyssenkrupp Industrial Solutions Ag

20150010974 - Method for degrading a readily-degradable resin composition: A method for degrading a readily degradable resin composition comprising an aliphatic polyester (A) which is biodegradable, and an aliphatic polyester (B′) which releases an acid upon hydrolysis and which is biodegradable at a higher degradation rate than that of the aliphatic polyester (A), the method comprising degrading the readily... Agent:

20150010975 - Extraction solvents derived from oil for alcohol removal in extractive fermentation: In an alcohol fermentation process, oil derived from biomass is hydrolyzed into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be catalytically (e.g., enzymatically) hydrolyzed into free fatty acids, which form a fermentation product... Agent:

20150010977 - Bioprocessing: Functionalized substrate materials, for example inorganic particles and/or synthetic polymeric particles, are used to enhance bioprocesses such as saccharification and fermentation.... Agent:

20150010976 - Regio- and enantioselective alkane hydroxylation with modified cytochrome p450: Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively using atmospheric dioxygen as an oxidant. Mutant 9-10A-A328V hydroxylates octane primarily at the 2-position to form S-2-octanol (40% ee). Another mutant, 1-12G, hydroxylates alkanes larger than... Agent:

20150010978 - Terpene and terpenoid production in prokaryotes and eukaryotes: Terpene synthases are enzymes that directly convert IPP & DMAPP to terpenes, such as fusicoccadiene. Described herein are methods and compositions for the production of terpenes and terpenoids for use as fuel molecules or other useful components. Genetically engineered enzymes capable of producing terpenes and terpenoids are also described.... Agent: Sapphire Energy, Inc.

20150010979 - Method for preparing immobilized angiogenin: Stabilized angiogenin compositions and methods of preparing a stabilized angiogenin compositions by covalent immobilization on a naturally occurring substrate, such as a polysaccharide substrate, are disclosed. In particular, the polysaccharide substrate includes galactose-rich polysaccharide.... Agent:

20150010980 - Composition for embedded microbial culture: Disclosed is a composition for embedded three-dimensional microbial culture, the composition including nanofibrillar cellulose and at least one nutrient source. Also disclosed is a method for the manufacture of a composition for embedded three-dimensional microbial culture, the method including the steps of providing nanofibrillar cellulose, mixing the nanofibrillar cellulose with... Agent: Upm-kymmene Corporation

20150010981 - Gh61 glycoside hydrolase protein variants and cofactors that enhance gh61 activity: The present invention provides various GH61 protein variants comprising various amino acid substitutions. The GH61 protein variants have an improved ability to synergize with cellulase enzymes, thereby increasing the yield of fermentable sugars obtained by saccharification of biomass. In some embodiments, sugars obtained from saccharification are fermented to produce numerous... Agent:

20150010982 - Methods and compositions for generating bioactive assemblies of increased complexity and uses: The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which takes advantage of the specific binding interaction between dimerization and docking domains (DDD)... Agent:

20150010983 - Compositions, methods and uses for inducing viral growth: Embodiments herein report methods, compositions and uses for inducing and/or accelerating viral growth. In certain embodiments, methods, compositions and uses generally related to copolymer compositions for inducing viral growth, reducing lag time and/or increasing viral plaque size. In other embodiments, methods, compositions and uses of copolymer compositions can be for... Agent:

20150010984 - Partial adaptation for butanol production: Provided herein are processes for producing an improved culture of cells comprising an engineered butanol biosynthetic pathway. The processes comprise (a) providing a cell culture of recombinant microorganisms comprising an engineered butanol biosynthetic pathway, wherein the engineered butanol biosynthetic pathway is minimal or not activated; and (b) growing the culture... Agent:

20150010985 - Methods and compositions for improving sugar transport, mixed sugar fermentation, and production of biofuels: The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods... Agent: Bp Corporation North America Inc.

20150010986 - Ettlia sp. strain having superior carbon dioxide fixation ability and lipid producing ability and use thereof: Provided are a new microalgae strain and a use thereof, and more particularly, Ettlia sp. YC001 (KCTC 12109BP) having high carbon dioxide fixability, lipid productivity and carotenoid productivity, and a use thereof. The strain may be used for producing high quality biodiesel by controlling a lipid content and a composition... Agent:

20150010987 - Method for producing euglena having high wax ester content: Provided is a method that is for producing Euglena having a high wax ester content, capable of more efficiently producing the Euglena having a high wax ester content by adding a nutrient before anaerobic fermentation to restore the efficiency of wax ester fermentation. The present invention relates to a method... Agent:

20150010988 - Method for removing protein from a food: A method for removing protein from a food includes adding a first group of enzymes into a food while cooking the food. The first group of enzymes decomposes protein in the food in a first enzyme reaction. Let a mixture of the first group of enzymes and the food rest... Agent:

20150010989 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent:

20150010990 - Integrated bio-reactor monitor and control system: Systems and methods for automatically controlling conditions of a process are disclosed. In one example, a controller is programmed with a sequence of steps and parameters required to carry out a bioreactor process. A sensor system interacts with the bioreactor to receive information related to a condition of the bioreactor... Agent:

20150010991 - Bio-sensing device: A bio-sensing device includes a first platform, a second platform, at least one first magnetic element, and at least one second magnetic element. The first platform is configured to support a microplate. The microplate has a plurality of wells, each of which stores a reagent and a plurality of microbeads.... Agent: Wistron Corporation

20150010992 - Optical reader systems and lateral flow assays: Systems and methods for determining the presence and/or amount of analytes in a fluid sample are described.... Agent: Quantrx Biomedical Corporation

20150010993 - System for conducting the identification of bacteria in urine: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical... Agent:

20150010994 - Non-invasive sensing of bioprocess parameters: A system and method for measuring at least one bioprocess parameter utilizes a barrier that separates an external sensor from a culture medium. The barrier allows analytes to diffuse in and out of the culture vessel, thereby allowing the bioprocess parameter to be measured non-invasively by the external sensor.... Agent: University Of Maryland Baltimore County

20150010995 - Microchip-based apparatus for examining platelet composite functions: There is provided a microchip-based platelet multi-function test apparatus. The apparatus includes a sample container configured to accommodate a blood sample therein, a stirrer that is installed inside the sample container and induces a shear flow in the blood sample, a parallel channel configured to divide and flow the blood... Agent: Korea University Research And Business Foundation

20150010996 - Cell culture device having culture medium replacement function: Provided is a small-scale cell culture apparatus having a culture medium replacement function for culturing cells in a small number of Petri dishes, the cell culture apparatus being capable of performing automatic replacement of the culture medium and cell culture within the same cavity and significantly reducing the apparatus cost.... Agent: Jtec Corporation

20150010997 - Methods and compositions for producing vitamin k dependent proteins: The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells.... Agent:

20150010998 - Anti-human ccr7 antibody, hybridoma, nucleic acid, vector, cell, pharmaceutical composition, and antibody-immobilized carrier: An object of the present invention is to provide a novel anti-human CCR7 antibody useful as a therapeutic agent for tissue fibrosis or cancer, and a pharmaceutical composition containing the anti-human CCR7 antibody, and the like. An anti-human CCR7 antibody specifically binding to an extracellular domain of human CCR7, having... Agent:

20150010999 - Synthetic attachment medium for cell culture: An aqueous cell culture medium composition includes an aqueous cell culture solution configured to support the culture of mammalian cells. The composition further includes a synthetic polymer conjugated to a polypeptide dissolved in the aqueous cell culture solution. The synthetic polymer conjugated to a polypeptide is configured to attach to... Agent:

20150011000 - Cryopreservation of biological cells and tissues: The method involves placing an oocyte cell in a cell holder (1), securing the cell holder in a treatment station, applying a treatment solution to the cell by washing the cell with the solution, and rapidly cooling the cell holder and cell to a predetermined cryopreservation temperature for cryopreservation of... Agent:

20150011002 - 2,4-pyrimidinediamine compounds and uses as anti-proliferative agents: The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.... Agent: Rigel Pharmaceuticals, Inc.

20150011001 - Compositions and methods for optimizing cleavage of rna by rnase h: The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer... Agent: Isis Pharmaceuticals, Inc.

20150011003 - Culture medium for proliferating stem cell, which contains sulfated compound: A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which promotes the growth of a stem cell in the presence of FGF, is useful for culturing stem cells.... Agent: Ajinomoto Co., Inc.

20150011004 - Systems and methods for expanding high density non-adherent cells: Embodiments described herein generally relate to systems and methods for promoting the expansion of high density non-adherent cells through the use of a cell growth chamber, a mass transfer device, and a fluid circulation loop. Improved cell growth is achieved in the cell growth chamber by using a chamber having... Agent: Terumo Bct, Inc.

20150011005 - Method for producing cell having nucleic acid introduced therein: A method for producing a cell having nucleic acid introduced therein and having low cytotoxicity is useful in primary cells and slowly dividing cells, for which nucleic acid introduction is difficult with conventional techniques. A method for introducing nucleic acid into a cell includes the steps of mixing a nucleic... Agent: National Cerebral And Cardiovascular Center

20150011006 - Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna: The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection... Agent: Centre National De La Recherche Scientifique

20150011007 - Synthetic transcriptional control elements and methods of generating and using such elements: Provided herein are nucleic acid constructs that contain a synthetic control element that includes a cis-regulator of translation, and an adapter translation-coupled regulator of transcription. Further provided herein are nucleic acid constructs that contain nucleic acid sequences under the control of the synthetic control elements. Also provided are compositions and... Agent:

20150011008 - Method of transferring gene into algal cell involving utilizing multiple square-wave pulses in three steps: To provide a technology that solves the above-mentioned problems, and is directly applicable to eukaryotic algal cells with cell-wall, the technology enabling gene transfer and transformation to be performed with high efficiency and good reproducibility irrespective of species of algae. Also provided is a method of transferring an exogenous gene... Agent: Kyoto University

  
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