Chemistry: molecular biology and microbiology inventions

20090280469 - Cell mass capable of serving as a primitive organ-like structure comprised of a plurality of cell types of somatic origin: The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures... Agent: Foley And Lardner LLP Suite 500

20090280470 - Extraction and diagnostic fluid devices, systems and methods of use: The present invention provides devices, systems and methods for RNA isolation from biological samples containing white blood cells, such as whole blood. The devices have a device body that includes a first chamber having a first membrane that selectively binds white blood cells, a second chamber having a second membrane... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20090280473 - Inhibition of membrane fusion proteins: Methods of inhibiting viral infection of a eukaryotic cell by a target virus having a class II virus fusion protein are provided. Also provided are methods of screening a test compound for the ability to inhibit infection by a virus having a class II viral fusion protein. Additionally provided herewith... Agent: Amster, Rothstein & Ebenstein LLP

20090280474 - Method for detecting a virus: This invention is related a method for increasing the sensitivity of detecting a viral target in a sample. The sensitivity may be increased by disrupting a complex comprising the target or by measuring the level of the target from a larger volume of the sample.... Agent: Paul D. Yasger Abbott Laboratories

20090280472 - Method for detection of antigens: The field of the invention relates generally to the detection of antigens, including, but not limited to, quantum dots (Qdots) and metal oxide nanoparticles. More specifically, the invention relates to the detection of antigens on a surface or in a source, which antigens include bacteria, viruses, and small proteins. In... Agent: Fish & Richardson P.C.

20090280471 - Methods for rapid identification of pathogens in humans and animals: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or... Agent: Casimir Jones, S.c.

20090280495 - Activating mutations of platelet derived growth factor receptor alpha (pdgfra) as diagnostic markers and therapeutic targets: This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules... Agent: Klarquist Sparkman, LLP

20090280480 - Devices from prion-like proteins: The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected with such polynucleotides; novel fibrils with specific functionalities and unusually high chemical and thermal stability; and methods of making and using the foregoing in, for example,... Agent: Marshall, Gerstein & Borun LLP

20090280492 - Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a... Agent: Wilson, Sonsini, Goodrich & Rosati

20090280476 - Droplet-based affinity assay device and system: The present invention relates to a droplet-based affinity assay device and system. According to one embodiment, a droplet microactuator is provided and includes an antibody immobilized on a surface. According to another embodiment, a droplet microactuator is provided and includes a droplet on the droplet microactuator, the droplet comprising an... Agent: Ward And Smith, P.A.

20090280475 - Droplet-based pyrosequencing: The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting sequencing protocols, such as the... Agent: Ward And Smith, P.A.

20090280481 - Enhanced sequencing by hybridization using pools of probes: The invention provides methods for sequencing by hybridization (SBH) using pools of probes that allow greater efficiency in conducting SBH by reducing the number of separate measurements of hybridization signals required to identify each particular nucleotide in a target nucleic acid sequence. The invention also provides pools and sets of... Agent: Marshall, Gerstein & Borun LLP

20090280490 - Expression profile algorithm and test for cancer prognosis: The present invention provides a noninvasive, quantitative test for prognosis determination in cancer patients. The test relies on measurements of the tumor levels of certain messenger RNAs (mRNAs). These mRNA levels are inserted into a polynomial formula (algorithm) that yields a numerical recurrence score, which indicates recurrence risk.... Agent: Genomic Health, Inc. C/o Kathleen Determann

20090280478 - Gene methylation and expression: The invention provides a method of analyzing the methylation status of all or part of an entire genome. Moreover, the invention features methods of and reagents for characterizing biological cells containing DNA that is susceptible to methylation. Such methods include methods of diagnosing cancer, e.g., breast cancer.... Agent: Fish & Richardson P.C.

20090280489 - Ig genes specific oligonucleotides and uses thereof: The present invention provides oligonucleotides for detection of rearrangement of immunoglobulin genes for identifying clonality of cells, cancer cells, hypermutation in immunoglobulin gene, antibody isotype producing cell and/or assaying B cell repertoire in a sample. The oligonucleotides disclosed in the present invention are very specific to the immunoglobulin genes.... Agent: Schwegman, Lundberg & Woessner, P.A.

20090280494 - Method for the detection of cytosine methylations in immobilized dna samples: A method is described for the analysis of cytosine methylation patterns in genomic DNA samples. In the first method step, the genomic DNA is isolated from cells or other accompanying materials and bound essentially irreversibly to a surface. Then the DNA bound to the surface is treated, preferably with a... Agent: Kriegsman & Kriegsman

20090280493 - Methods and compositions for the prediction of response to trastuzumab containing chemotherapy regimen in malignant neoplasia: The invention relates to methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of neoplastic disease. Neoplastic disease is often caused by chromosomal rearrangements which lead to over- or underexpression of the rearranged genes. The invention discloses genes which are overexpressed in neoplastic tissue and are useful as... Agent: Siemens Corporation Intellectual Property Department

20090280485 - Methods and reagents for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population: The invention relates to methods and reagents for the determination of telomere length in tissue sections by the single cell telomeric mapping technique based on a fluorescent in situ hybridization step using a telomere-specific probe and an interpolation step using a standard curve correlating fluorescent intensity and telomere length obtained... Agent: Moore & Van Allen PLLC

20090280484 - Methods for gene mapping and haplotyping: The present invention is directed to methods for providing a definitive haplotype of a subject. The haplotype information generated by the methods described herein is more accurate than that provided by prior art methods that only give an inferred haplotype. Accordingly, in one aspect the present invention provides a method... Agent: Birch Stewart Kolasch & Birch

20090280487 - Methods for producing olfactory gpcrs: The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell... Agent: Arena Pharmaceuticals, Inc. Bozicevic, Field & Francis LLP

20090280483 - Methods for screening interleukin-6 (il-6) signal transduction inhibitors: The present invention provides methods for screening compounds which inhibit activation of a member of the IL-6 signaling pathways, comprising: (a) a positive screening step using a cell capable of being killed by IL-6 stimulation to select compounds which inhibit death of the cell when it is stimulated by IL-6;... Agent: Birch Stewart Kolasch & Birch

20090280497 - Multiplex detection compositions, methods, and kits: The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in... Agent: Life Technologies Corporation C/o Intellevate

20090280496 - Non-invasive method for diagnosing fetal cells and cancer cells: A non-invasive method for determining the developmental age of a fetus or detecting cancer cells in a sample is provided. The method utilizes, for example, a sample of blood from a pregnant female and telomeric nucleic acid probes.... Agent: Kelley Drye & Warren LLP

20090280482 - Novel nucleic acid sequences encoding adenylate kinases, alcohol dehydrogenases, ubiquitin proteases, lipases, adenylate cyclases, and gtpase activators: The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the... Agent: Millennium Pharmaceuticals, Inc.

20090280486 - Oligonucleotides for detecting nucleic acids of pathogen causing sexually transmitted diseases: The present invention relates to oligonucleotides hybridizable with nucleic acids of pathogens causing sexually transmitted diseases, kits comprising them, and processes for amplifying and detecting viral nucleic acids using them. The present oligonucleotides completely overcome problems of false-negative and false-positive products in detection of pathogens causing sexually transmitted diseases using... Agent: Miles & Stockbridge PC

20090280491 - Predicting cancer invasiveness: Provided are methods of determining the likelihood of a human cancer being invasive. Also provided are methods of determining whether a lung adenocarcinoma is a bronchioloalveolar carcinoma (BAC). Additionally provided are methods of deciding a course of treatment for a patient with a cancer.... Agent: Sonnenschein Nath & Rosenthal LLP

20090280488 - Prophylactic/therapeutic agent for neurodegenerative disease: (b) a protein having an amino acid sequence resulting from deletion, substitution, addition or insertion of one or more amino acids in the amino acid sequence of SEQ ID NO: 2, 4, 6 or 8 and having binding activity to an abnormal polyglutamine protein produced in a neurodegenerative disease.... Agent: Arthur G. Schaier Carmody & Torrance LLP

20090280498 - Rapid and efficient capture of dna from sample without using cell lysing reagent: Nucleic acids can be made available for amplification or other treatment after admixture of a sample with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, thereby releasing the nucleic acids from the polymer.... Agent: Philip S. Johnson Johnson & Johnson

20090280477 - Turn over probes and use thereof for nucleic acid detection: The invention provides turnover probes for use in a variety of detection assays, for example, nucleic acid detection assays. In addition, the invention provides assays, for example, nucleic acid detection assays, using such turnover probes.... Agent: Goodwin Procter LLP Patent Administrator

20090280479 - Use of free circulating dna for diagnosis, prognosis, and treatment of cancer funding: A method of detecting circulating DNA in a body fluid. The method comprises identifying a subject suffering from or at risk for developing cancer, obtaining a body fluid sample from the subject, and determining the sequence integrity of circulating DNA in the sample, wherein the circulating DNA is not purified... Agent: Hogan & Hartson L.L.P.

20090280501 - A method and a kit for diagnosing type 2 diabetes, metabolic syndrome, sub clinical atherosclerosis, myocardial infarct, stroke or clinical manifestations of diabetes: A method and a kit for diagnosing or prognosing susceptibility to develop type 2 diabetes, the metabolic syndrome, sub clinical atherosclerosis, myocardial infarct, stroke or clinical manifestations of diabetes in a subject. The method comprises detecting and quantifying the amount of bound protein (s), (apoCIII, apoCI, apoA1 or apoE) on... Agent: Pepper Hamilton LLP

20090280502 - Anti-2-o-desulfated acharan sulfate antibody and its application: An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The antibody that reacts with 2-O-desulfated acharan sulfate can be produced by immunizing a mammal using as an antigen a substance... Agent: Knobbe Martens Olson & Bear LLP

20090280500 - Assay for generation of a lipid profile using fluorescence measurement: The present invention relates to a method of generating a lipid profile for a sample solution. The method comprising: a first step of determining the concentration of total lipoprotein in a first aliquot of the sample using fluorescence analysis; a second step of determining the concentration of total cholesterol in... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20090280499 - Method and kit for detecting, or determining 3,4- methylenedioxymethamphetamine: The invention provides a hapten, an immunogen comprising the hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with MDMA.... Agent: Blank Rome LLP

20090280503 - Method for detecting and treating skin disorders: The invention provides for methods of detecting and treating diseased tissue, particularly in skin diseases or disorders, such as psoriasis, scleroderma, eczema or atopic dermatitis tissue. The method involves administrating a composition comprising an antibody specific to the diseased tissue to a patient. After administration, the antibody in the composition... Agent: Klauber & Jackson

20090280505 - Method for detecting lysosomal storage diseases: A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood can be employed as a specimen. The assay... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090280504 - Ns1-np diagnostics of influenza virus infection: The present application describes methods for assessing influenza infection, including prognosis. An assay that determines the amount of the NS1 and NP proteins of influenza virus shows enhanced sensitivity and reliability compared to either antigen alone. Many formats employ pan-specific antibodies (i.e., that react with all or at least with... Agent: Townsend And Townsend And Crew, LLP

20090280506 - Sf, a novel family of taste receptors: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.... Agent: Townsend And Townsend And Crew, LLP

20090280510 - Antibodies specific to heterodimers of bcl-2 family and uses thereof: Isolated antibodies specifically binding to heterodimers of the Bcl-2 family and uses thereof for detecting presence of Bcl-2 heterodimers in a patient.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090280508 - Methods and reagents for preparing and using immunological agents specific for p-glycoprotein: This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090280509 - Surface acoustic wave immunosensor for diagnosing allergy disease and method for diagnosing allergy disease using the same: A surface acoustic wave (SAW) immunosensor for diagnosing allergy disease includes one or more SAW devices on each of which allergens derived from one allergy-causing substance are fixed and an allergen derived from another allergy-causing substance is not included, that is, allergens derived from different allergy-causing substances being fixed on... Agent: Sughrue Mion, PLLC

20090280511 - Methods for selecting candidate peptides presented on the surface of cancer cells following their binding to mhc class i molecules: An objective of the present invention is to provide methods for selecting candidate peptides presented on the surface of cancer cells following binding to MHC class I molecules, wherein the peptides are involved in the stimulation of T cell immunity (cellular immunity). The present inventors discovered a new principle of... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090280512 - Tumor marker for renal cancer and method for determination of occurrence of renal cancer: The present invention provides a tumor marker more highly specific to renal cancer. The present invention provides a method for identifying the morbidity of renal cancer. A tumor marker for renal cancer comprising proteins identified from renal cancerous tissue. A method for identifying the morbidity of renal cancer by using... Agent: Cheng Law Group, PLLC

20090280507 - Method for measurement of sars virus nucleocapsid protein, reagent kit for the measurement, test device, monoclonal antibody directed against sars virus nucleocapsid protein, and hybridoma capable of producing the monoclonal antibody: The present invention provides a method for measuring SARS virus nucleocapsid protein (SARS-NP) using first and second antibodies both binding specifically to SARS-NP, wherein the first or second antibody is an antibody recognizing an epitope located in a region (Region C) of amino acid 283 to 422 from the N-terminus... Agent: Sughrue Mion, PLLC

20090280513 - Compositions and methods for detection, prevention, and treatment of anthrax and other infectious diseases: Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods of immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40... Agent: Nixon Peabody, LLP

20090280515 - Compositions and methods for the modulation of pgrmc1: The present invention provides for novel assays and the use of such assays for screening compounds that affect PGRMC1's and related homologue's ability to catalyze the incorporation of cholesterol into membranes. The present invention also provides for methods and compositions for affecting incorporation of cholesterol into membranes. The invention also... Agent: Foley & Lardner LLP

20090280514 - Method for measurement of cholesterol in high-density lipoprotein: The present invention provides a method, a reagent and a kit for the simple and accurate measurement of HDL cholesterol. The method for the measurement of cholesterol in high-density lipoprotein in a sample comprises reacting the sample with i) cholesterol esterase and cholesterol oxidase or ii) cholesterol esterase, oxidized coenzyme... Agent: Fitzpatrick Cella Harper & Scinto

20090280516 - Crystal structure of aldehyde dehydrogenase and methods of use thereof: The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090280519 - Biomarkers for assessing liver function: A method for assessing liver function in an individual, which method comprises determining the level of methylarginine(s) (such as ADMA and/or SDMA) and the ratio of ischemia modified albumin (IMA):albumin ratio (IMAR) in the individual, thereby to assess liver function in the individual.... Agent: Foley And Lardner LLP Suite 500

20090280520 - Fluorescent semiconductor particles, method of manufacturing the same, biosubstance fluorescent labeling agent employing the same, and bioimaging method thereof: Disclosed is a fluorescent semiconductor particle having a core/shell structure composed of a core particle as a semiconductor particle, and a shell layer by which the core particle is covered, wherein the core particle has a different chemical composition from that of the shell layer; the core particle has an... Agent: Lucas & Mercanti, LLP

20090280522 - Method for rapid detection and evaluation of cultured cell growth: Provided is a method and system for the rapid and accurate detection of growth and metabolism of a cellular microorganism in a population of microorganisms in a non-liquid, culture medium. Further provided is a gelled culture medium containing a non-toxic, water-soluble, phosphorescent compound which measures oxygen content (partial pressure) of... Agent: Montgomery, Mccracken, Walker & Rhoads, LLP

20090280521 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics: The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.... Agent: Mccarter & English, LLP Boston

20090280517 - Methods of diagnosis and prognosis for a muscular dystrophy: The invention relates to the treatment, diagnosis, and prognosis of a muscular dystrophy or myopathy. The present inventors have found that the quantity of mu-crystallin is increased in a muscular dystrophy. In particular, the inventors have found that mu-crystallin is increased in facioscapulohumeral muscular dystrophy (FSHD). Based on the inventors'... Agent: Morgan Lewis & Bockius LLP

20090280518 - System for high throughput measurement of mechanical properties of cells: A system for measuring a mechanical property of a cell is provided. The system includes a body having a channel therethrough with a first end and a second end, the channel including at least one cell deforming feature configured to deform a cell passing through the channel. A first sensor... Agent: Wolf Greenfield & Sacks, P.C.

20090280523 - Method for determining the molecular composition of a target tissue or another body structure, and its diagnostic applications: The present invention relates to a sampling instrument adapted for taking a sample in situ and in vivo or taking a sample ex vivo of a target tissue or body structure, in a maximum quantity of less than 10−6 g, said instrument comprising an elongated active member (10) with a... Agent: Oliff & Berridge, PLC

20090280524 - Solid culture medium for the detection and/or the species discrimination of glycopeptide-resistant enterococci: The present invention relates to a solid culture medium for the detection and/or discrimination, among glycopeptide-resistant enterococci, of the groups of species E. faecalis and/or E. faecium belonging to the groups of resistance to the VanA/VanB glycopeptides, and E. gallinarum/E. casseliflavus belonging to the group of resistance to the VanC... Agent: Birch Stewart Kolasch & Birch

20090280525 - Process for the enantioselective reduction and oxidation, respectively, of steroids: e

20090280526 - Method for in vitro molecular evolution of protein function:

20090280527 - Amylase variants:

20090280529 - High throughput transfection of filamentous fungi: The present invention provides a method for the transfection of filamentous fungal cells, comprising providing a multitude of containers, filling into each container an amount of polymer needed for the transfection, filling the cells to be transfected as well as an aqueous solution of transfection reagent into each of the... Agent: Nixon & Vanderhye, PC

20090280528 - Method for cloning and expression of nrui restriction endonuclease: Recombinant DNA encoding NruI- and SboI-like restriction endonucleases and methylases and their amino acid sequences are provided as well as methods for expressing the enzymes in transformed host cells and purifying the enzymes.... Agent: Harriet M. Strimpel, D. Phil.

20090280530 - Novel collagen-like protein clac, precursor thereof and genes encoding the same: A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific to these proteins; and methods of diagnosing treating and preventing Alzheimer's disease by using the same.... Agent: Studebaker & Brackett PC

20090280531 - Preparation of soluble capsid proteins of picornaviruses using sumo fusion technology: A method of producing a soluble capsid protein of a picornavirus using a novel and efficient SUMO fusion protein expression system.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090280532 - Serum-free mammalian cell culture medium, and uses thereof: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or... Agent: Life Technologies Corporation C/o Intellevate

20090280533 - Serum-free mammalian cell culture medium, and uses thereof: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or... Agent: Life Technologies Corporation C/o Intellevate

20090280534 - Recombinant production of serum albumin: The present invention relates to modified nucleotide sequences encoding serum albumin, wherein the mRNA sequence has been codon optimized for expression in a filamentous host cell. Furthermore the present invention relates to serum albumin produced in filamentous fungi or loaded by contacting serum albumin with an extract of a filamentous... Agent: Novozymes North America, Inc.

20090280535 - Sumo fusion protein expression system for producing native proteins: A simple and efficient SUMO fusion protein expression system for producing native proteins.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090280536 - Expression system for proteins: The invention provides a novel system for the tunable expression of nucleic acids encoding e.g., polypeptides such as recombinant proteins in prokaryotic systems. The system is based on the ability of T7 lysozyme (T7Lys) to inhibit the activity of T7RNAP. Expression of T7Lys can be continuously adjusted as its expression... Agent: Drinker Biddle & Reath (dc)

20090280540 - Directed enrichment of genomic dna for high-throughput sequencing: The present invention provides microarrays of oligonucleotide primer pairs, and in particular, microarrays of primers that comprise at least one cleavable linkage. Also provided are methods to capture oligonucleotide primer pairs from one or more microarrays, and methods to use the captured oligonucleotide primer pairs, such as for amplification of... Agent: Life Technologies Corporation C/o Intellevate

20090280539 - Dna polymerases and related methods: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects by an intercalating dye. Therefore, the mutant polymerases are useful in a variety of disclosed... Agent: Townsend And Townsend And Crew, LLP

20090280537 - Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations: The present invention provides methods, compositions and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DPD) gene in chromosome 1. Also provided are mutant forms of DPD.... Agent: Townsend And Townsend And Crew, LLP

20090280538 - Methods and compositions for nucleic acid sample preparation: Provided are methods and compositions for the production of linear single-stranded nucleic acids, which can be used as templates in high-throughput sequencing systems. Also provided are methods and compositions for the production of closed single-stranded nucleic acid loops, which can be used as templates in high-throughput sequencing systems.... Agent: Quine Intellectual Property Law Group, P.C.

20090280541 - Beta-xylosidase for conversion of plant cell wall carbohydrates to simple sugars: Xylose-containing plant material may be hydrolyzed to xylose using a β-D-xylosidase which exhibits unexpectedly high activity. The enzyme has a kcat value for catalysis of approximately 185 sec−1 for 1,4-β-D-xylobiose (X2) when measured at a pH of 5.3 and a temperature of 25° C.; this is at least 10-fold greater... Agent: Usda-ars-office Of Technology Transfer National Ctr For Agricultural Utilization Research

20090280542 - Method of production of l-amino acids: An isolated polynucleotide encodes a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, with the L-aspartic acid at position 5 of the amino acid sequence replaced by another proteinogenic amino acid, and possesses citrate synthase activity. In addition, a vector comprises the polynucleotide and a bacterium comprises... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090280543 - Regioselective glycosylation: We describe a screening method for the identification of glycosyltransferase polypeptides that regioselectively modify aglycones and the use of said glycosyltransferase polypeptides to modify aglycones.... Agent: Speckman Law Group PLLC

20090280544 - Method for producing optically active 2-benzyloxycyclohexylamine: The present invention relates to a method for the enantioselective acylation of trans-2-benzyloxycyclohexylamine or cis-2-benzyloxycyclohexylamine, according to which an enantiomer mixture of 2-benzyloxycyclohexylamine is reacted with an acylation agent in the presence of a hydrolase. The invention also relates to a method for producing optically active trans-stereoisomers of 2-benzyloxycyclohexylamine.... Agent: Connolly Bove Lodge & Hutz, LLP

20090280545 - Molecule production by photosynthetic organisms: The present invention provides compositions and methods for producing products by photosynthetic organisms. The photosynthetic organisms are genetically modified to effect production, secretion, or both, of products. The methods and compositions are particularly useful in the petrochemical industry.... Agent: Quine Intellectual Property Law Group, P.C.

20090280546 - Yeast strain for production of four carbon alcohols: Yeast cells with a reduced general control response to amino acid starvation were found to have increased tolerance to butanol in the growth medium. The reduced response was engineered by genetic modification of a gene involved in the response, a GCN gene, to eliminate activity of the encoded protein. Yeast... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090280547 - Cellooligosaccharide-fermentative zymobacter transformed microorganisms: This invention provides transformed microorganisms which can produce ethanol from cellooligosaccharide, by introducing β-glucosidase gene by recombinant DNA method, into microorganisms belonging to genus Zymobacter which cannot utilize cellooligosaccharide.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090280548 - Method and device for producing hydrogen: In a step of contacting an organic material including formic acid ions and a carbon source other than the formic acid ions with a microorganism having a formate dehydrogenase gene and a hydrogenase gene under an anaerobic condition, concentration of the formic acid ions in the organic material is set... Agent: Nixon & Vanderhye, PC

20090280549 - Method for treating body fluid: The invention provides a body fluid treatment method for selective ex vivo killing of malignant lymphoma cells, leukemia cells or activated macrophages in a body fluid, the body fluid treatment method comprising: an addition step wherein a compound represented by formula (I) below is added to a body fluid containing... Agent: Drinker Biddle & Reath (dc)

20090280550 - Polymer-factor ix moiety conjugates: Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the... Agent: Nektar Therapeutics

20090280551 - A reagent formulation using ruthenium hexamine as a mediator for electrochemical test strips: Described herein are various embodiments of a test strip, which may be capable of measuring an analyte. The test strip may include a working electrode and a reference electrode where the reagent formulation is disposed on the working electrode. The reagent formulation may be coated onto the test strip. The... Agent: Philip S. Johnson Johnson & Johnson

20090280552 - Methods and compositions for cancer therapy using a novel adenovirus: The invention comprises a novel virus that can kill mammalian cancer cells efficiently. The virus produces a novel protein that converts two non-toxic prodrugs into potent chemotherapeutic agents. These chemotherapeutic agents are produced locally and help the virus kill the cancer cells as well as sensitize them to radiation. In... Agent: Rader, Fishman & Grauer PLLC

20090280553 - Method for designing mutated enzyme, method for preparing the same, and mutated enzyme: It is intended to provide a novel method for improving an enzyme hydrolyzing an a-1,6-glycosidic linkage. A mutated enzyme is designed by specifying one or more amino acids selected from the group shown below in an amino acid sequence of an enzyme (an enzyme to be mutated) that hydrolyzes an... Agent: Edwards Angell Palmer & Dodge LLP

20090280554 - Modified vitamin k-dependent polypeptides: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.... Agent: Fish & Richardson P.C.

20090280555 - Enzyme treatment of foodstuffs for celiac sprue: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.... Agent: Bozicevic, Field & Francis LLP

20090280556 - Mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers and methods and kits for targeting the antigen: This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin, recombinant cells expressing it, methods for targeting... Agent: Townsend And Townsend And Crew, LLP

20090280557 - Method, a device, and an additive for digesting organic matter: A method of producing biogas by anaerobic digestion of organic matter may include adding cobalt, iron, and hydrochloric acid to an organic matter; bringing the organic matter in contact with biogas-producing bacteria; and digesting the organic matter under anaerobic conditions in a reactor while producing biogas and a digested sludge.... Agent: Harness, Dickey & Pierce, P.L.C

20090280558 - Process for dynamic kinetic resolution (dkr) of racemic compounds in (hydro) fluorocarbon solvents: A process for preparing a third compound stereo-selectively which process comprises reacting a substrate comprising a first enantiomeric compound with a racemisation catalyst to give a second enantiomeric compound, and concurrently reacting the second enantiomeric compound in the presence of a biological catalyst to give the third compound, wherein the... Agent: Cook Alex Ltd

20090280559 - Genetic sequencer incorporating fluorescence microscopy: A fluorescence microscopy sequencer comprises a fluid transport subsystem in which reagents are pumped through a series of multi-port valves to a mixer or one or more flow cells, or directly into the flow cell(s). The one or more multi-port valves can be mounted upon a fluids manifold having syringe... Agent: Vedder Price P.C.

20090280560 - Yeast cell surface display of proteins and uses thereof: The present invention provides a genetic method for tethering polypeptides to the yeast cell wall in a form accessible for binding to macromolecules. Combining this method with fluorescence-activated cell sorting provides a means of selecting proteins with increased or decreased affinity for another molecule, altered specificity, or conditional binding. Also... Agent: Greenlee Winner And Sullivan P C

20090280561 - Fusion protein of hiv regulatory/accessory proteins: The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins... Agent: Law Office Of Salvatore Arrigo

20090280562 - Materials and methods for preparing dimeric growth factors: Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a... Agent: Townsend And Townsend And Crew LLP

20090280563 - Method for production of antigen-specific hybridoma using artificial lymph node with good efficiency: o

20090280564 - Method for inducing differentiation of mesodermal stem cells, es cells, or immortalized mesodermal stem cells into neural cells: In addition, according to the present invention, mesodermal stem cells can be differentiated into neural cells by immortalizing the mesodermal stem cells by highly expressing or activating an immortalization gene in the mesodermal stem cells and culturing the cells under an appropriate condition. The methods of the present invention are... Agent: Foley And Lardner LLP Suite 500

20090280565 - High-rate perfusion bioreactor: The present invention relates to a novel perfusion bioreactor allowing continuous medium feed and extraction of metabolites or other desired products from cells. The invention is useful for plant cell cultures but may also be used for mammalian cell cultures, insect cell cultures and bacterial cell cultures. The design of... Agent: Choate, Hall & Stewart LLP

20090280566 - Methods for increasing germination frequency and/or vigor by cold shock treatment of conifer somatic embryos during development: In one aspect, a method is provided for increasing germination vigor and/or frequency of conifer somatic embryos produced in vitro. The method comprises (a) incubating a plurality of immature conifer somatic embryos for a first incubation period in, or on, a first development media at a temperature in the range... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20090280567 - Stabilized sirnas as transfection controls and silencing reagents: RNA molecules, including siRNA molecules and related control, trackability and exaequo agents with specific stability modifications are provided. These molecules are particularly advantageous as transfection control reagents. The molecules include first and second 5′ terminal sense nucleotides with 2′-O-alkyl groups and a label on the first 5′ terminal sense nucleotide,... Agent: Merchant & Gould PC

20090280568 - S100b mini-promoters: Isolated polynucleotides comprising an S100B promoter are provided, where an S100B regulatory element is operably joined to an S100B basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest,... Agent: Bozicevic, Field & Francis LLP

20090280569 - Chloramphenicol resistance selection in bacillus licheniformis: The present invention relates to a modified Bacillus licheniformis host cell, wherein one or more naturally occurring chromosomal chloramphenicol acetyl transferase encoding gene(s), cat, has been inactivated. The inactivation of the chromosomal cat gene(s) allows the use of chloramphenicol as an efficient selective agent in methods for DNA introduction into... Agent: Novozymes North America, Inc.

20090275011 - Sessile stem cells: Sterile, virally safe, heterologous, homologous, isologous or autologous tissue, tissue-typed or not tissue-typed, which contains predifferentiated and/or differentiable sessile stem cells and which can be used for wound closure and/or promotion of wound healing.... Agent: Baker Botts L.L.P.

20090275012 - Process for determining s-nitrosothiols in biological fluids: A process for determining S-nitrosothiols, in particular S-nitrosoglutathione, in biological fluids that is easy, selective, cheap with respect to the prior art, which requires the use of equipment commonly available in laboratories, at low cost, which can be used by not qualified operators. The process is based on the hydrolysis... Agent: Abelman, Frayne & Schwab

20090275016 - Arrayed detector system for measurement of influenza immune response: A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip... Agent: Nixon Peabody LLP - Patent Group

20090275013 - Method for preparing a monoclonal antibody to the common epitope of nonstructural nss protein of watermelon silver mottle virus and assay for detection of serological related species in the genus tospovirus with the monoclonal antibody: The invention is an assay for detection of Watermelon silver mottle virus (WSMoV)-serogroup tospoviruses using a monoclonal antibody and a method for preparing the monoclonal antibody. A hybridoma cell line that produces a monoclonal antibody against the NSs proteins of WSMoV-serogroup tospoviruses was produced. The hybridoma cell line produces a... Agent: Frenkel & Associates, P.C.

20090275015 - Non-invasive respiratory rapid diagnosis method: A non-invasive method for rapidly determining the specific presence or absence of respiratory pathogens and chemical entities.... Agent: David Allen Hall

20090275014 - Thermal cycling method: This invention provides a method for carrying out nucleic acid amplification reactions involving heating and cooling of samples in sample vessels utilizing a heat block comprising a liquid. The method can be used to perform multiple nucleic acid amplification reactions simultaneously in which each of the reactions is performed so... Agent: Wilson, Sonsini, Goodrich & Rosati

20090275031 - Biomolecular nano device: Methods for measuring environmental parameters using chemical recording are provided. In some embodiments, the methods include generating a polymer comprising an ordered series of chemical units, wherein the position and number of each chemical unit in the polymer is indicative of a reading of the environmental state variable at a... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20090275030 - Cell calcification suppressing proteins, and genes of the proteins: This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and... Agent: Morgan Lewis & Bockius LLP

20090275023 - Compositions and methods for detecting borrelia afzelii: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the p24 gene for the outer surface protein of... Agent: Medical Diagnostic Laboratories LLC

20090275040 - Detecting bcl-b expression in cancer and uses thereof: Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast cancer, prostate cancer, lung cancer, or gastric cancer.... Agent: Patent Correspondence Arnall Golden Gregory LLP

20090275018 - Detection of hepatotoxic cyanobacteria: The present invention relates to methods and kits for the detection of toxic cyanobacteria, in particular of hepatotoxin-producing cyanobacteria.... Agent: Townsend And Townsend And Crew, LLP

20090275037 - Fluorescent double stranded dna binding dyes: The present invention is directed to a fluorescent dye comprising a benzothiazolium moiety and a pyrimidinium moiety connected by a mono-methine bridge, characterized in that (i) the 2-position of the pyrimidine carries a substituent which starts with a C-atom and (ii) the 5- and 6-positions of the pyrimidine ring are... Agent: Roche Diagnostics Operations Inc.

20090275043 - Genetic variants in the tcf7l2 gene as diagnostic markers for risk of type 2 diabetes mellitus: Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090275025 - Hpv detection and quantification by real-time multiplex application: The present invention relates to amplification primers and detection probes, which are useful for the detection of human papillomaviruses (HPV), and more particularly of HPV, which can be oncogenic for the mucosal epithelia. The amplification and detection systems provided by the present invention are group-targeted systems, namely A5-, A6- A7-,... Agent: Nixon & Vanderhye, PC

20090275027 - Medium scale intergration of molecular logic gates in an automaton: Compositions and methods for optically detecting the presence of a plurality of oligonucleotides in a sample, wherein each oligonucleotide to be detected comprises consecutive nucleotides having a sequence different than the remaining oligonucleotides of the plurality are provided.... Agent: Cooper & Dunham, LLP

20090275038 - Method and apparatus for forensic screening: This invention relates to methods and system for forensic screening. More specifically, this invention relates to various methods to detect or screen for at least one designated genetic sequences in a plurality of biological sample 40 using a template 30 in conjunction with a laboratory management software 24 to automatically... Agent: Butler, Snow, O'mara, Stevens & Cannada PLLC

20090275044 - Method for detecting human papillomavirus mrna: An in vitro method is provided for screening human female subjects to assess their risk of developing cervical carcinoma which comprises screening the subject for expression of mRNA transcripts from the E6 and optionally the L1 gene of human papillomavirus, wherein subjects positive for expression of L1 and/or E6 mRNA... Agent: Wolf Greenfield & Sacks, P.C.

20090275045 - Method for detecting mammary cancer cells: The present invention provides a novel method for detecting mammary cancer cells which uses, as an index, an expression level of a specific gene in human mammary cancer tissue (or cells). The method is characterized by including (1) measuring an expression level of a gene having a specific nucleotide sequence... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090275042 - Method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator: The present invention relates to a method of detecting and/or quantifying expression of a target protein candidate in a cell, and to a method of identifying a target protein of a small molecule modulator.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090275028 - Method of detecting target nucleic acid: The present invention provides a method of detecting a target nucleic acid which includes a step of examining whether a washing step has been normally conducted. In an aspect of the invention, a monitoring nucleic acid probe to monitor the washing level is used. The probe shows a change in... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090275039 - Methods for detection and quantification of small rna: Disclosed are methods, kits, and components for detecting small RNA molecules, such as microRNA and siRNA, in a sample. The methods utilize primers and reporter molecules comprising non-natural bases. The disclosed kits may include one or more components for performing the disclosed methods.... Agent: Foley & Lardner LLP

20090275024 - Novel centrerosome-associated protein and applications thereof: A method for diagnosing a genetic disease associated with disturbances in mitotic spindle organization or with cell division anomalies or both, which comprises demonstrating a functional alteration of the gene encoding an ASAP protein comprising at least the following steps of: obtaining DNA containing the gene encoding the ASAP protein... Agent: Dickinson Wright PLLC

20090275017 - Novel nucleoside or nucleotide derivative and use thereof: In one embodiment, the nucleoside or nucleotide of the present invention has a fluorescent dye selected from the group consisting of 5-FAM, 6-FAM, 5-TAMRA, 6-TAMRA, DANSYL, 5-HEX, 6-HEX, 5-TET, 6-TET, 5-ROX and 6-ROX or a quencher dye selected from the group consisting of DABCYL, BHQ1 and BHQ2, which is attached... Agent: Birch Stewart Kolasch & Birch

20090275021 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis: Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.... Agent: Fennemore Craig

20090275041 - Nucleic acid and corresponding protein entitled 193p1e1b useful in treatment and detection of cancer: A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The... Agent: Agensys C/o Morrison & Foerster LLP

20090275019 - Pancreatic cancer genes: The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20090275026 - Primer and probe for detection of mycobacterium intracellulare, and method for detection of mycobacterium intracellulare by using the primer and probe: According to the detection method of the present invention, any false-positive result in diagnosis can be eliminated and detection or diagnosis of M. intracellulare can be carried out with higher accuracy, more preciseness, and more specifically compared to a conventional diagnostic method employing a cell culture assay or a PCR... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090275035 - Primers for human mitochondrial hypervariable region and method for detecting human dna by using the primers: The present invention relates to primer pairs for human mitochondrial hypervariable region and a method for detecting human DNA by using the primer pairs.... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20090275032 - Reprogramming a cell by inducing a pluripotent gene through use of an hdac modulator: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises inhibiting the activity of... Agent: Whyte Hirschboeck Dudek S.c. Intellectual Property Department

20090275022 - Stat6 effects on livestock animal growth: The present invention provides for selection of livestock animals, including bovines, whose genotypes based in the STAT6 gene are correlated with phenotypes reflecting desirable carcass and feedlot traits. These phenotypes include back fat (BFAT), calculated yield grade (CALCYG), cutability (CUT), hot carcass weight (HCW), dry matter intake (DMI), days on... Agent: Townsend And Townsend And Crew, LLP

20090275036 - Systems and methods for real time single molecule sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Life Technologies Corporation C/o Intellevate

20090275029 - Systems and methods to quantify and amplify both signaling and probes for cdna chips and gene expression microarrays: The invention provides a series of reagent compositions and methods for making and amplifying novel cDNA based probe sets from RNA samples to improve analysis with gene expression arrays. The methods globally produce probe sets with common universal linkers at one or both ends, called WRAP-Probes, wherein the linkers do... Agent: Fish & Richardson P.C.

20090275034 - Temperature control system: Single molecule technologies generally require sensitive optical detection and the ability to operate at multiple temperatures simultaneously in different parts of the instrument. The system for controlling the temperature of a microfluidic device and methods for controlling the temperature of sequencing reactions includes a chamber for receiving a microfluidic device,... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090275020 - Traceability of cellular cycle anomalies targeting oncology and neurodegeneration: The present invention relates to the field of medicine and biology. It concerns a novel test for screening and for therapeutic follow-up in oncology. More particularly, it relates to diagnostic and/or therapeutic tests in oncology and on neurodegenerative diseases. It is a diagnostic test and a prognostic test for various... Agent: Jackie Jay Schwartz

20090275033 - Uses of bnipxl-beta in premature canities: The invention also concerns methods for screening molecules modulating the expression of a gene coding for BNIPXL-beta and molecules modulating the activity of the BNIPXL-beta polypeptide, in order to identify an agent for use for cosmetic or therapeutic purposes in the field of pigmentation. The invention also encompasses various uses... Agent: Cooper & Dunham, LLP

20090275048 - Anti-acharan sulfate antibody and its application: An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to acharan... Agent: Knobbe Martens Olson & Bear LLP

20090275046 - Complement factor h protein as a biomarker of parkinson's disease: The present invention relates to a Complement Factor H protein as a biomarker for neurodegenerative disease, including Parkinson's disease, and the related diseases. More specifically, the present invention relates to the identification of a Complement Factor H protein, useful for the screening, diagnosis, and differentiation between neurodegenerative diseases.... Agent: Benjamin A. Adler, Phd, Jd

20090275047 - Crystal structure of human soluble adenylate cyclase: The invention provides the crystal structure of the solAC catalytic domain. The structure is set out in Tables 1 to 5. The structure may be used in to model the interaction of ligands such as pharmaceutical compounds with this protein, and to determine the structure of related adenylate cyclase molecules.... Agent: Millen, White, Zelano & Branigan, P.C.

20090275050 - 14273 receptor, a novel g-protein coupled receptor: The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases,... Agent: Millennium Pharmaceuticals, Inc.

20090275049 - Epha4 polypeptide having a novel activity and use thereof: The present invention provides a polynucleotide which consists of a partial sequence of a polynucleotide encoding the amino acid sequence as shown in SEQ ID NO: 2, wherein the former polynucleotide encodes a polypeptide consisting of a partial amino acid sequence of SEQ ID NO: 2 whose N-terminus starts between... Agent: Darby & Darby P.C.

20090275051 - Luminogenic and nonluminogenic multiplex assay: A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.... Agent: Schwegman, Lundberg & Woessner, P.A.

20090275056 - Methods for obtaining antibodies: The invention is directed towards a method of enriching a population of cells in those cells that produce an antibody which recognises an antigen of interest. In particular, an untagged antigen is used in conjunction with a polyclonal antibody to isolate cells recognizing said antigen.... Agent: Klauber & Jackson

20090275055 - Monoclonal antibodies specific to denatured human class i leucocyte antigens: [MEANS FOR SOLVING THE PROBLEMS] It was discovered that injection of denatured recombinant HILA-A*2402 heavy chain proteins to mouse for immunization led to establish HLA class I-specific antibody binding all of denatured HLA-A, B and C. The present invention is a monoclonal antibody specifically binding HLA-A, HLA-B and HLA-C heavy... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20090275057 - Diagnostic markers predictive of outcomes in colorectal cancer treatment and progression and methods of use thereof: Colorectal cancer patients with operable tumors must decide whether to receive adjuvant therapy after surgical resection in order to reduce their chances of recurrence. Current clinical guidelines are crudely based on the stage of the disease, as well as a few other clinicopathologic features. The instant invention integrates data from... Agent: William C. Fuess

20090275058 - Method for specific detection of salmonella spp.: A method for specific detection of the presence of Salmonella spp. in a sample that is suspected to contain Salmonella spp. and which further comprises one or more other microorganism(s).... Agent: Berenbaum Weinshienk PC

20090275052 - Adjustable molecular motor micropower biosensor and its application: A regulable molecular motor micropower biosensor comprises: a rotary motor, an optical energy conversion device, a signal molecular output device, a power resource system, a protective layer, a supporting material, and a bilayer lipid membrane fixing material. The molecular motor micropower biosensor is used for detecting biological macromolecules, viral molecules,... Agent: Knobbe Martens Olson & Bear LLP

20090275053 - Cell-based pcsk9 screening assay: The present invention includes a PCSK9 activity inhibition assay system, kits, compositions and methods. The present invention includes a cell having a first vector capable of expressing a catalytic fragment of PCSK9, a second vector capable of expressing a prodomain of PCSK9 and a V5 protein with a detectable label.... Agent: Chalker Flores, LLP

20090275054 - Pancreatic cancer genes: The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20090275061 - method to measure serum biomarkers for the diagnosis of liver fibrosis: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different liver fibrosis-associated serum biomarkers in a serum sample, which can be used for the diagnosis of liver fibrosis. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization... Agent: Weili Cheng

20090275060 - Determination of serum anti-mullerian hormone as a diagnostic test for spay in companion animals: This invention relates to non-surgical assays that can be used to determine whether an animal that has a non-postpartum anestrous period of three months or greater, such as a dog or a cat, has been spayed. In particular, the present invention relates to devices, kits and methods that allow correlation... Agent: Casimir Jones, S.c.

20090275059 - Marker proteins for diagnosing liver disease and method of diagnosing liver disease using the same: Using the protein chip technology, biological samples such as sera are subjected to proteome analysis. Thus, a protein which is a human fibrinogen α-E chain decomposition product and has a molecular weight of 5,900, a protein which is an apolipoprotein AII decomposition product and has a molecular weight of 7,800,... Agent: Kratz, Quintos & Hanson, LLP

20090275062 - Method of tacrolimus extraction and quantification using aqueous detergents: The present invention relates to a method of extracting tacrolimus in a test blood sample to use in a tacrolimus quantification assay. The method of the present invention extracts tacrolimus in non-precipitating, non-denaturing aqueous environment, avoiding cumbersome manual pretreatment procedures or the use of organic solvents. The method of the... Agent: Paul D. Yasger Abbott Laboratories

20090275063 - Distinguishing cells in a sample by inactivating extracellular enzyme before releasing intracellular enzyme: A method for detecting the absence or presence of cells of interest in a liquid sample, wherein: (a) the sample: (i) comprises an extracellular medium containing an enzyme with a measurable activity; and (ii) is suspected of containing cells of interest that contain an enzyme with said measurable activity; and... Agent: Mueting, Raasch & Gebhardt, P.A.

20090275064 - Methods to identify therapeutic agents: As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cholesterol oxidation or ozonation products that can act as chemotactic attractants of macrophages, can promote differentiation of monocytes into macrophages and can increase expression of E-selectin and Class A scavenger receptor (SR-A). The present... Agent: The Scripps Research Institute

20090275066 - Immobilization of membrane porteins onto supports via an amphiphile: The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof, characterized in that said membrane protein is attached to said support using an amphiphilic molecule with which said membrane... Agent: Pepper Hamilton LLP

20090275065 - Methods and compounds for detecting beta-lactamase activity: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective... Agent: Foley & Lardner LLP

20090275067 - Method of acquiring hepatic oval cells: Provided are a method of isolating and identifying hepatic oval cells from the liver, and a method of single cell culture of hepatic oval cells. A method of separating and/or acquiring hepatic oval cells from a mammal, comprising a step for examining the expression of CD133, CD45 and Ter119. Particularly,... Agent: Leydig Voit & Mayer, Ltd

20090275068 - Method of determining chymase activity with secretory leukocyte protease inhibitor: It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a... Agent: Philip S. Johnson Johnson & Johnson

20090275070 - Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators: This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as... Agent: Kenyon & Kenyon LLP

20090275073 - Diagnosis device and diagnosis method: A diagnosis device includes: a pretreating portion configured to suspend tissue to obtain a suspension; and an analyzing portion configured to analyze the suspension.... Agent: Kimble Intellectual Property Law, PLLC

20090275071 - Diagnostic composition and article for monitoring intravaginal infections: The present invention provides a non-toxic diagnostic composition for intravaginal monitoring of vaginal infections. The present invention further provides a diagnostic article for intravaginal monitoring of vaginal infections with the article including an absorbent material for absorbing vaginal secretions and a composition suitable for identification of the pH or the... Agent: Winston & Strawn LLP Patent Department

20090275072 - In vitro bio-reactor circuit: Embodiments of the invention provide bio-reactor circuits for in vitro research applications. One embodiment provides a bio-reactor circuit comprising at least one bio-reactor and a pump fluidically coupled to the at-least-one bio-reactor. The bio-reactor comprises a housing having inlet and outlet ports and first and second chambers. The chambers are... Agent: Bell & Associates

20090275069 - Pancreatic cancer genes: The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20090275074 - System and method for performing g protein coupled receptor (gpcr) cell assays using waveguide-grating sensors: The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells... Agent: Corning Incorporated

20090275075 - Methods and systems for ensuring the security of food commodities: Aspects include claims, systems, and methods for testing food commodities, including without limitation bulk food commodity stores to identify the presence of contaminants. Such contaminants tested for may include biological, chemical, or radio nuclear material. Another aspect is marking and/or tracking food commodity stores that have been certified as either... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20090275076 - Cell sample preparation method and apparatus: An apparatus and method for automatic thin-layer cell sample slide preparation without requiring human intervention are disclosed. According to one embodiment, a cell sample is measured to derive a cell sample measurement. An estimation of total cellularity of the cell sample is determined based upon the cell sample measurement. A... Agent: Withrow & Terranova, P.l.l.c.

20090275077 - Methods of obtaining optically active epoxides and vicinal diols from styrene oxides: The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific meso-epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for obtaining... Agent: Fish & Richardson P.C.

20090275078 - Alpha-amylase variants: The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular increased starch affinity relative to the parent alpha-amylase.... Agent: Novozymes North America, Inc.

20090275081 - Biotin-ligase system for secretion of biotinylated protein: The present invention provides methods of metabolically biotinylating recombinant proteins. Cell lines and specific protein and nucleic acid constructs for use in the methods of the present invention are also provided herein.... Agent: Townsend And Townsend And Crew, LLP

20090275080 - Glucoamylase variants with altered properties: The present disclosure relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present disclosure provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions and cleaning compositions. The disclosure also relates to DNA constructs encoding the variants and methods of... Agent: Danisco US Inc. Attention: Legal Department

20090275082 - Mast cell-derived membrane proteins: An originally developed efficient signal sequence trapping method was used to screen a cDNA library prepared from cultured mast cells derived from mouse bone marrow. As a result, genes encoding type I membrane proteins and comprising a single immunoglobulin domain in the extracellular domain and a motif for transmitting an... Agent: Fish & Richardson PC

20090275079 - Novel genes encoding novel proteolytic enzymes: The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein and fragments thereof. The invention also relates to methods of using these... Agent: Nixon & Vanderhye, PC

20090275083 - Isolated peptides having phospholipase inhibitory activity: The invention provides for isolated peptides having phospholipase inhibitory activity, polypeptides comprising phospholipase inhibitory activity and lipases capable of being inhibited by the isolated peptides and/or polypeptides comprising phospholipase inhibitory activity. The invention also relates to nucleic acid constructs, recombinant expression vectors, and recombinant host cells comprising the polynucleotides as... Agent: Novozymes North America, Inc.

20090275084 - Long-acting epo polypeptides and derivatives thereof and methods thereof: A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to an EPO peptide are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.... Agent: Pearl Cohen Zedek Latzer, LLP

20090275085 - enzyme for obtaining prebiotic oligosaccharides: An industrially viable process of obtaining prebiotic oligosaccharides using a new Xanthophyllomyces dendrorhous enzyme, characterized by showing α-glucosidase activity is provided. A process of obtaining an enzymatic product with α-glucosidase activity as well as the substantially pure enzyme with α-glucosidase activity, are also provided. The enzymatic product and the enzyme... Agent: Berenbaum Weinshienk PC

20090275086 - Assembly of large nucleic acids: A method to assemble any desired nucleic acid molecule by combining cassettes in vitro to form assemblies which are further combined in vivo, or by assembling large numbers of DNA fragments by recombination in a yeast culture to obtain desired DNA molecules of substantial size is described.... Agent: Morrison & Foerster LLP

20090275087 - Asymmetric adapter library construction: The present invention provides methods and compositions for asymmetrically tagging a nucleic acid fragment using asymmetric adapters.... Agent: Bozicevic, Field & Francis LLP

20090275088 - Processes for the preparation of highly pure plasmid compositions: The present disclosure generally relates to processes for preparing highly pure plasmid compositions. The processes generally involve treating a composition comprising plasmid DNA with a polypeptide to digest colanic acid. The treated plasmid DNA is then separated from the treated composition.... Agent: Bryan Cave LLP

20090275089 - Mutant phosphoribosylpyrophosphate synthetase and method for producing l-histidine: The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP synthetase which is resistant... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090275090 - L-amino acid-producing bacterium and a method for producing l-amino acids: A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the β-glucoside PTS activity, and collecting the L-amino acid from the... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090275091 - L-amino acid-producing bacterium and a method for producing l-amino acids: A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the mannose PTS activity, accumulating the L-amino acid in the medium... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090275092 - Method for producing 4-hydroxy-l-isoleucine: A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090275093 - Biochemical synthesis of 1,4-butanediamine: The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein the increased ODC activity is obtained by means of overexpression of an... Agent: Nixon & Vanderhye, PC

20090275094 - Process for producing sulfur-containing hydroxycarboxylic acid: wherein R1 is the same as defined above, to the action of microbial cells of a microorganism belonging to the genus Pseudomonas, Rhodococcus or Bacillus capable of converting the ketol into a corresponding α-hydroxycarboxylic acid compound, or a treated material thereof, thereby producing the sulfur-containing α-hydroxycarboxylic acid without using a... Agent: Sughrue Mion, PLLC

20090275095 - Dna encoding a protein having a d-lactate dehydrogenase activity and uses thereof: This invention provides a polynucleotide that encodes a protein having lactate dehydrogenase activity and such protein that can be used for producing D-lactic acid. This polynucleotide has the nucleotide sequence as shown in SEQ ID NO: 1 (a), and it hybridizes under stringent conditions with a probe comprising all or... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090275096 - Microorganisms for the production of methacrylic acid: The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric... Agent: Mcdermott, Will & Emery

20090275097 - Primary alcohol producing organisms: The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.... Agent: Mcdermott, Will & Emery

20090275098 - Systems and processes for enhanced yield from fermentations that contain xylose: A system and process for the utilization of xylose during fermentation is described. The system uses a fermenter and a separate reactor to isomerize the xylose to xylulose. The separation of the two processes allows the optimization of each process since the isomerization operates ideally in a calcium free environment... Agent: White-welker & Welker, LLC

20090275100 - Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis: The present invention relates to nucleic acid inhibitors, compositions and method for enhancing synthesis of nucleic acid molecules. In a preferred aspect, the invention relates to inhibition or control of nucleic acid synthesis, sequencing or amplification. Specifically, the present invention discloses nucleic acids having affinity for polypeptides with polymerase activity... Agent: Life Technologies Corporation C/o Intellevate

20090275099 - Methods and compositions for treating diseases and conditions associated with mitochondrial function: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, mitochondrial F1F0 ATP hydrolase... Agent: Casimir Jones, S.c.

20090275101 - Pancreatic cancer genes: The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20090275102 - Ehrlichia disulfide bond formation proteins and uses thereof: Novel genes encoding homologous immunoreactive thio-disulfide oxidoreductases, or disulfide bond formation (Dsb) proteins from Ehrlichia chaffeensis and Ehrlichia canis are disclosed. While the E. chaffeensis and E. canis Dsb proteins are at most only 31% or less homologous to other known Dsb proteins, the Ehrlichia Dsbs contain a cysteine active... Agent: Fulbright & Jaworski, LLP

20090275103 - Recombinant hexose oxidase: v

20090275104 - Bacillus licheniformis chromosone: The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods... Agent: Novozymes, Inc.

20090275105 - Process for the production of bromelain by means of substances that induce proteins in pineapple plants: Provided are methods of producing, via induction, plant products such as bromelain from plants of the genus Ananas established in vitro. A process for extracting bromelain from tissues of the pineapple (Ananas comosus) plant that have been established and induced in vitro is provided. The plants have a higher proteolytic... Agent: Feldmangale, P.A.

20090275106 - Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090275107 - Scalable production method for aav: A method for producing AAV, without requiring cell lysis, is described. The method involves harvesting AAV from the supernatant. For AAV having capsids with a heparin binding site, the method involves modifying the AAV capsids and/or the culture conditions to ablate the binding between the AAV heparin binding site and... Agent: Howson & Howson LLP

20090275108 - bacillus pumilus strain for high yield of tetramethylpyrazine: This invention provides a high-yield bacterial strain for producing tetramethylpyrazine named Bacillus pumilus RX3-17. The strain has been deposited in China Center for Type Culture Collection on Apr. 19, 2006. The deposit number is CCTCC M 206043. The bacterial strain, isolated from soil, is rod-shaped, 1.5 μm to 3.0 μm... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090275109 - Bacillus strains useful for animal odor control: A composition is provided that includes Bacillus subtilis 2084 (NRRL B-50013) or a strain having all of the identifying characteristics of the Bacillus subtilis 2084 (NRRL B-50013), B. subtilis 27 (NRRL B-50105) or a strain having all of the identifying characteristics of the B. subtilis 27 (NRRL B-50105), and B.... Agent: Whyte Hirschboeck Dudek S.c. Intellectual Property Department

20090275110 - Microorganism that displays biotin on cell surface: Provided is a microorganism that can display, on the cell surface, any molecules other than a molecule comprising amino acids, more specifically, a microorganism that displays biotin on a cell surface. The microorganism is capable of co-expressing a biotinylating enzyme and an acceptor peptide having a sequence recognized by the... Agent: The Webb Law Firm, P.C.

20090275111 - Anaerobically compostable polymeric compositions, articles and landfill biodegradation: Compostable hydrocarbon polymers, composites, and articles anaerobically biodegrade in landfills in a relatively short time. Composite polymeric articles and sheets such as indoor or outdoor signs, billboards, banners, images, protective barriers, backdrops and wall coverings have very useful service durations and yet are landfill biodegradable.... Agent: Wood, Herron & Evans, LLP

20090275112 - Nutrient additives for start-up and sustained operation of a biological filter apparatus: A biological filter apparatus for biological degradation of contaminants in an air stream is operated by passing the air stream through a filter chamber containing a structure supporting a population of microbes and collecting water that drains from the structure and spraying the collected water onto the structure, whereby the... Agent: Smith-hill And Bedell, P.C.

20090275113 - Thermal cycling apparatus: This invention provides an apparatus for providing heating and cooling of samples in sample vessels having uniform temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity. The system employs a heat block containing a liquid composition to efficiently transfer... Agent: Wilson, Sonsini, Goodrich & Rosati

20090275114 - Vibratory mixer: To simplify mixing systems without stirrer systems and to minimize cleaning and validation operations, it is proposed that a vibratory mixer with a vibratory mechanism should have a container. Into this container is inserted a bag which, after use, need not be cleaned and is instead replaced by a new... Agent: George Pappas Harrison Place

20090275115 - Microreactor: Chemical and biological reactors, including microreactors, are provided. Exemplary reactors include a plurality of reactors operable in parallel, where each reactor has a small volume and, together, the reactors produce a large volume of product. Reaction systems can include mixing chambers, heating/dispersion units, reaction chambers, and separation units. Components of... Agent: Wolf Greenfield & Sacks, P.C.

20090275118 - Bacteria detecting instrument, bacteria detecting method, and bacteria detecting kit: A micro array instrument is used in which an oligonucleotide based on a species- or genus-specific nucleotide sequence of subject bacteria is immobilized on a surface of a substrate. By confirming whether the oligonucleotide immobilized on the substrate has hybridized with a probe prepared from a test sample, bacteria contained... Agent: Drinker Biddle & Reath (dc)

20090275116 - Metallic pcr frames: This invention along with certain methods of manufacture significantly contributes to the deterministic consistency of PCR results and the overall cycle time. The ability to achieve a significant reduction in costs is realized from the purchase of reusable PCR frames as well as the savings obtained from the costs associated... Agent: Venugopal Subramanyam

20090275117 - Slip cover for heated platen assembly: A heated platen assembly for use in a biological testing device is disclosed having a heated platen defining a plurality of optical openings configured to permit radiation to pass through the heated platen, a light transmissive slip cover configured to cover at least one of the plurality of optical openings,... Agent: Life Technologies Corporation C/o Intellevate

20090275119 - Liquid chromatograph: The present invention relates to a liquid chromatography apparatus X, which is provided with a deaerator 4. The liquid chromatography apparatus X is further provided with a dissolved oxygen density adjusting means for maintaining a density of dissolved oxygen in an eluting solution to be supplied to a column 60... Agent: Rader Fishman & Grauer PLLC

20090275120 - Extraction of co2 gas from engine exhaust: A photo-bioreactor is used for extraction of carbon dioxide from exhaust gases of an engine used for compression of natural gas by providing a series of vessels and in each contacting the gases with a labyrinthine flow of water containing photo-synthetic organisms. Each vessel receives the gases in series and... Agent: Ade & Company Inc.

20090275121 - Vibrational mixer: A vibrational mixer (1), in particular a single-path mixer for use in single-path bioreactors (4) with flexible walls, consisting of a mixer shaft (2) that can be set into longitudinal motions by a drive (8), with at least one mixing element (3), wherein at least one channel (13) is arranged... Agent: Casella & Hespos

20090275122 - Polypeptides having colanic acid-degrading activity: The present disclosure generally relates to polypeptides having colanic acid-degrading activity and methods of using the same. Polynucleotides encoding such polypeptides are also described. The polypeptides may be used, for example, in processes for degrading colanic acid, processes for the removal of endotoxins from biological samples, and processes for purifying... Agent: Bryan Cave LLP

20090275125 - Human t1r2 taste receptor nucleic acids and cells containing these nucleic acids: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20090275124 - Methods and compositions comprising anti-idiotypic antibodies to anti-mmp-14 antibodies: Provided are anti-idiotypic antibodies specific for a CDR of an anti-MMP-14 antibody for use as reagents in novel assays for anti-MMP-14 antibodies, pharmaceutical compositions and vaccines.... Agent: Lando & Anastasi, LLP

20090275123 - Modified vitamin k-dependent polypeptides: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.... Agent: Fish & Richardson P.C.

20090275126 - Antibodies against insulin-like growth factor i receptor and uses thereof: Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20090275130 - Biomimetic nucleic acids: The present invention is directed to nucleic acids with biomimetic properties and methods for producing said nucleic acids. In particular, this invention relates to nucleic acids exhibiting biomimetic properties in relation to proteins such as growth factors, hormones and/or other cell signaling proteins. Biomimetic properties may generally be defined as... Agent: Bio Tex, Inc.

20090275128 - Medium and culture of embryonic stem cells: Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if high levels of fibroblast growth factor, gamma... Agent: Quarles & Brady LLP

20090275131 - Method for production of mast cells from stem cells: Provided are methods for generating mast cells from pluripotent stem cells in vitro. Methods are disclosed for the differentiation of pluripotent cells, such as iPS cells and/or human embryonic stem cells, into mast cells. The resulting mast cells may be used for various purposes including screening cells for drug development... Agent: Fulbright & Jaworski L.L.P.

20090275129 - Tissue engineered blood vessels: Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.... Agent: Philip S. Johnson Johnson & Johnson

20090275127 - Viable cells from frozen umbilical cord tissue: Viable progenitor cells are extracted from frozen umbilical cord tissue. In embodiments, the umbilical cord tissue is a blood vessel bearing perivascular Wharton's jelly, and the extracted progenitor cells are HUCPVCs.... Agent: Clark & Elbing LLP

20090275132 - Method for purifying cardiomyocytes or programmed cardiomyocytes derived from stem cells or fetuses: The inventors of the present invention found that cardiomyocytes were effectively and highly selected and purified by culturing cardiomyocytes derived from embryonic stem cells in the culture medium under a condition selected from a low-serum-supplemented condition, a low-glucose-supplemented condition, a low-nutritional condition, a low calcium condition, a mildly-acidic pH condition,... Agent: Drinker Biddle & Reath (dc)

20090275133 - Antisense modulation of c-reactive protein expression: Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive... Agent: Jones Day For Isis Pharmaceuticals, Inc.

20090275134 - Compositions of active wnt protein: Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue. Methods for isolation of Wnt utilize detergents that maintain the solubility of the modified protein.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090275135 - Mammalian cytokines; receptors; related reagents and methods: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20090275137 - High affinity tcr proteins and methods: T cell receptors (TCRS) that have higher affinity for a ligand than wild type TCRs are provided. These high affinity TCRs are formed by mutagenizing a T cell receptor protein coding sequence to generate a variegated population of mutants of the T cell receptor protein coding sequence; transforming the T... Agent: Greenlee Winner And Sullivan P C

20090275136 - Nuclear targeting sequence: The present provides nuclear localization signaling (NLS) sequences derived from titin, comprised of amino acids 181-220: SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR and fragments thereof, such as amino acids 193-208: VQGEEEVP AKKTKTIV; amino acids 199-208: VPAKKTKTIV; and amino acids 200-206: PAKKTKT. The NLS sequences can be linked to agents, such as peptides,... Agent: The Webb Law Firm, P.C.

20090275138 - Production of raav in vero cells using particular adenovirus helpers: The present invention relates to methods and materials for recombinant adeno-associated virus production. More particularly, in some embodiments the invention contemplates the use of an adenovirus known as Simian Adenovirus 13 (SAdV-13) and Vero cells for production of recombinant adeno-associated virus (rAAV).... Agent: Marshall, Gerstein & Borun LLP

20090275139 - Materials and methods relating to the production and maintenance of cell lines: The invention provides methods for maintaining cell lines from primary cells, i.e., non-transformed cells, using expression of the signal transducer of activation and transcription (STAT). The methods are particularly suitable for maintenance of B-cells.... Agent: Dann, Dorfman, Herrell & Skillman

20090263780 - Organ preservation fluid: Novel organ preservation fluids, as well as related articles and methods, are disclosed.... Agent: Yanming Wang

20090263781 - Composition for preserving platelets and method of using the same: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally,... Agent: Morris Manning Martin LLP

20090263782 - Reaction apparatus: An apparatus 20 for biological or chemical reactions, in particular PCR, includes a heat removal module 22 adapted to receive snugly a reaction vessel 24 in such a manner as to create good thermal conductivity contact between the module and the vessel. The heat removal module 22 is formed of... Agent: J. Bruce Hoofnagle

20090263783 - Nucleic sequence and deduced protein sequence family with human endogenous retroviral motifs, and their uses: The present invention provides a translational product encoded by the nucleotide sequence of SEQ ID NO: 2, which corresponds to the gag gene of an endogenous human retrovirus named HERV-7q. The present invention also provides methods for diagnosing a neurological or autoimmune disease in a patient.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090263784 - Three-dimensional structure of prostaglandin d synthase and utilization thereof: A method of designing an anti-allergic agent, sleep controlling agent, anti-obesity agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090263787 - method for screening of infectious agents in blood: This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of infectious agent related antibodies and/or antigens in a serum sample, which can be used to screen for infectious agents in blood. It also discloses an efficient formula to make a mixed SAM that can greatly enhance... Agent: Weili Cheng

20090263788 - Efficient algorithm for pcr testing of blood samples: Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level. Samples are formed into pools which are subsequently tested for virus contamination by a high-sensitivity test such as PCR. The... Agent: Kauth , Pomeroy , Peck & Bailey ,llp

20090263786 - Mass spectrometric analysis method: Methods of using mass spectrometry and in particular matrix assisted laser Ligand-Complex from Target and desorption-ionization (MALDI) mass spectrometry to analyze, or otherwise detect the presence of or determine the identity of intact ions of undigested, unfragmented covalently stabilized supramolecular target-ligand-complexes, as well as the use of these methods in... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090263785 - Modified hiv-1 peptides and use thereof in the detection of anit-hiv antibodies: The invention relates to synthetic peptides having sequence (III), which are derived from HIV-1 virus gp41 and which can be used in immunoassays for the detection of infections caused by HIV-1 viruses. The invention also relates to the method of preparing said peptides, to compositions and kits containing same and... Agent: Jacobson Holman PLLC

20090263799 - Assay for prostate cancer: In certain embodiments, a method for detecting a prostate proliferative cell disorder, a prostate cancer or a prostate tumor and/or categorizing Gleason's Sum of the tumors includes performing a digital rectal examination on a subject; obtaining one or more expressed prostatic secretion (EPS) samples from the subject; measuring PSA levels... Agent: Perkins Coie LLP

20090263792 - Atopic dermatitis marker and technique of using the same: It is an object of the present invention to find substances that can be used as disease markers for atopic dermatitis and the present invention provides a method for determining atopic dermatitis, including measurement of the expression of specific proteins and/or their genes in skin cells and/or skin tissues, wherein... Agent: Knobbe Martens Olson & Bear LLP

20090263804 - Biomarkers for aging: A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified multiple groups of genes expressed in the hippocampi of mammals, where the genes were expressed at different levels for several ages. The aging changes in... Agent: Mcdermott Will & Emery LLP

20090263810 - Bisulfite conversion of dna: The present invention provides an improved method for the bisulfite conversion of DNA, and facilitates the analysis of cytosine methylation of genomic DNA. Novel combinations of denaturing solvents, new reaction conditions and new purification methods provide surprisingly efficacious methods for bisulfite conversion of DNA relative to prior art methods. The... Agent: Dla Piper LLP (us)

20090263815 - Cell culture system, process for the production thereof, and the use thereof in preclinical investigation: The invention relates to a cell culture system, in particular for the preclinical testing of active substances, comprising a first and a second compartment which are in communication with one another via a separating layer between the first and the second compartment, the separation layer being permeable for cellularly secreted... Agent: Knobbe Martens Olson & Bear LLP

20090263791 - Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods: This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3′-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods... Agent: Cooper & Dunham, LLP

20090263795 - Diagnostic methods involving determining gene copy numbers and snps in the fcyrii/fcyriii gene cluster, and probes for use in such methods to detect susceptibility to and treatment efficacy in autoimmune diseases: The invention relates to diagnostic methods to predict whether a subject is predisposed for acquiring a disease or to predict the therapy responsiveness of an individual patient. Provided is a method for determining whether a subject is predisposed for developing an autoimmune disease, comprising determining in a sample isolated from... Agent: Hoffmann & Baron, LLP

20090263819 - Gene and protein expression profiles associated with the therapeutic efficacy of egfr-tk inhibitors: The present invention provides protein and gene expression profiles indicative of whether a patient afflicted with non-small cell lung cancer is likely to be responsive to treatment with a therapeutic compound that is a EGFR-TK inhibitor. By identifying such responsiveness, a treatment provider may determine in advance those patients who... Agent: Nuclea Biotechnologies, LLC

20090263808 - Genetic analysis for stratification of cancer risk: The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of two or more genes, in combination, to identify individuals with increased or decreased risk of cancer. Exemplified is risk assessment for breast cancer in women. In addition, personal... Agent: Fulbright & Jaworski L.L.P.

20090263794 - High throughput flow through sample preparation using magnetic beads: A polymerase chain reaction system for analyzing a sample containing nucleic acid includes providing magnetic beads; providing a flow channel having a polymerase chain reaction chamber, a pre polymerase chain reaction magnet position adjacent the polymerase chain reaction chamber, and a post pre polymerase magnet position adjacent the polymerase chain... Agent: Lawrence Livermore National Security, LLC

20090263816 - Labelled beads: A labelled polymeric bead wherein individual beads comprise a primary particle formed of a synthetic polymeric material, and at least one secondary particle entrapped within the primary particle of the bead and being comprised of a synthetic polymer material incorporating reporter moieties.... Agent: Goodwin Procter LLP Patent Administrator

20090263806 - Method for detecting chikungunya virus: Compositions, methods and kits for detecting Chikungunya viral nucleic acids. Particularly described are methods for detecting very low levels of the viral nucleic acids using nucleic acid amplification.... Agent: Gen Probe Incorporated

20090263789 - Method for detecting nucleic acid sequences: The invention is directed to a method for detecting a target nucleic acid sequence by non-linear amplification.... Agent: Cheryl H Agris Phd

20090263798 - Method for identification of novel physical linkage of genomic sequences: The invention is directed to methods to identify the location in a genome of a nonfixed or multicopy genomic element using microarrays or sequencing.... Agent: Connolly Bove Lodge & Hutz, LLP

20090263818 - Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by ugt1a1 enzyme or whose metabolic intermediate is metabolized by the enzyme: A method of estimating a risk of the expression of an adverse drug reaction caused by the administration of irinotecan, and a method of reducing the adverse drug reaction caused by the administration of irinotecan. A polymorphism on the basis of a difference in the repeating numbers of TA repetitive... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20090263800 - Methods and compositions for diagnosing and monitoring transplant rejection: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same... Agent: Morrison & Foerster LLP

20090263796 - Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases: Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or... Agent: Morrison & Foerster LLP

20090263802 - Methods and compositions for efficient base calling in sequencing reactions: The present invention is directed to methods and compositions for acquiring nucleotide sequence information of target sequences. In particular, the present invention provides methods and compositions for improving the efficiency of sequencing reactions by using fewer labels to distinguish between nucleotides and by detecting nucleotides at multiple detection positions in... Agent: Morgan, Lewis & Bockius, LLP

20090263817 - Methods for diagnosing and treating systemic lupus erythematosus disease and compositions thereof: The present invention is directed to novel methods for diagnosis and prognosis of Systemic lupus erythematosus by identifying differentially expressed genes. Moreover, the present invention is also directed to methods that can be used to screen test compounds and therapies for the ability to inhibit systemic lupus erythematosus. Additionally, methods... Agent: Wyeth Patent Law Group

20090263809 - Methods for identification of bioagents: Methods for detecting and identifying known and unknown bioagents, particularly bacteria, by nucleic acid amplification and amplicon size determination are provided. Nucleic acid amplification utilises multiple primers which hybridize to conserved bioagent ribosomal sequence regions and which bracket variable bioagent ribosomal sequence regions to produce multiple amplicons that uniquely identify... Agent: Morrison & Foerster LLP

20090263790 - Methods for identifying functionally related genes and drug targets: The identification and evaluation of mRNA and protein targets associated with mRNP complexes and implicated in the expression of proteins involved in common physiological pathways is described. Effective targets are useful for treating a disease, condition or disorder associated with the physiological pathway.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20090263805 - Methods of identifying point mutations in a genome that affect the risk for or the age of appearance of disease: The invention relates to a method for identifying inherited point mutations in a targeted region of the genome in a large population of individuals and determining which inherited point mutations are deleterious, harmful or beneficial. Deleterious mutations are identified directly by a method of recognition using the set of point... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090263803 - Mirnas differentially expressed in lymph nodes from cancer patients: The present invention provides diagnostics and/or prognostic methods by identifying miRNAs that are differentially expressed or mis-regulated in various states of diseased, normal, cancerous, and/or abnormal tissues, including but not limited to cervix, skin, colon, breast, bladder, esophagus, liver, ovary, prostate, lung, pancreas, thyroid, kidney, stomach, testicle, uterus, spleen, tongue,... Agent: Fullbright & Jaworski L.L.P.

20090263793 - Novel method for diagnosing of mycobacterium tuberculosis: The present invention relates to a method and a kit for detecting Mycobacterium tuberculosis (MTB) or Nontuberculous mycobacteria (NTM) of patients. The present invention also relates to primers and probes used to detect Mycobacterium tuberculosis (MTB) or Nontuberculous mycobacteria (NTM) by performing PCR.... Agent: Wpat, PC Intellectual Property Attorneys

20090263807 - Optical detection field having diamond-like carbon thin film formed therein: An optical detection field, wherein a diamond-like carbon thin film containing therein fluorine is formed on a surface facing an existence region of a substance.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090263820 - Optimization of gene expression analysis using immobilized capture probes: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers... Agent: Eric P. Mirabel

20090263801 - Phenotype-genotype relationship in age-related macular degeneration: Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take... Agent: Banner & Witcoff, Ltd.

20090263814 - Physiogenomic method for predicting metabolic and cardiovascular side effects of thiazolidinediones: Disclosed herein are genetic markers related to the efficacy and/or safety of thiazolidinedione therapy identified by a physiogenomic methodology that correlates the genetic markers with a physiological response. The genetic markers described herein were not previously associated with the efficacy and/or safety of thiazolidinedione therapy. The markers related to safety... Agent: Cantor Colburn, LLP

20090263797 - Reversible di-nucleotide terminator sequencing: The present teachings provide methods, compositions, and kits for synthesizing and sequencing nucleic acids. In some embodiments, reversible di-nucleotide compounds are employed along with cleaving reactions that remove a label and a blocking moiety. Improved sequencing efficiency is achieved by the rapid polymerase-mediated incorporation of reversible di-nucleotide compounds. In some... Agent: Life Technologies Corporation C/o Intellevate

20090263813 - Ribonucleotide tag nucleic acid detection: The present application provides polynucleotides comprising 5′-tails with sequence segments useful for the detection of target nucleic acid sequences, and methods for their use in detecting target nucleic acids. The polynucleotides are used to amplify a subsequence of a target nucleic acid in the presence of one or more ribonucleotides.... Agent: Townsend And Townsend And Crew, LLP

20090263811 - Target base discrimination method: A target base-specific primer for use in discrimination of the base type of a target base in a nucleic acid in a nucleic acid sample, which is capable of discriminating the target base clearly with less possibility of false positive, and a target base discrimination method using the target base-specific... Agent: Scully Scott Murphy & Presser, PC

20090263812 - Use of id4 for diagnosis and treatment of cancer: The invention relates to a method of determining whether a human subject is suffering from or at risk for developing pancreatic cancer by determining the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a biological sample from a human subject. Also disclosed... Agent: Hogan & Hartson L.L.P.

20090263824 - Detection of neurodegenerative disease: Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods for diagnosing a neurodegenerative disease in a subject, and methods for determining the efficacy of a drug against a neurodegenerative... Agent: Woodcock Washburn LLP

20090263823 - Glyceroglycolipid antigen of mycoplasma pneumoniae: The present invention provides a novel glyceroglycolipid produced by Mycoplasma pneumoniae. The glyceroglycolipid can be used as a diagnostic marker for a disease caused by Mycoplasma pneumoniae.... Agent: Foley And Lardner LLP Suite 500

20090263822 - In vitro procedure for diagnosis and early diagnosis of neurodegenerative diseases: An in vitro process for the detection and early detection of neurodegenerative diseases, for determination of the severity, and to evaluate the progression of and render a prognoses of neurogenerative diseases, in a patient suffering from a subjectively or objectively detectable cognitive impairment, by determining the concentration of an analyte... Agent: Heslin Rothenberg Farley & Mesiti PC

20090263826 - Means and method for diagnosing hemolytic anemia: The present invention relates to a method for diagnosing hemolytic anemia or a predis-position thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present... Agent: Connolly Bove Lodge & Hutz, LLP

20090263827 - Method for determining health status by analyzing analytes: A method to extract information from samples taken at different times from a mammalian. These samples are analyzed with respect to one or more analytes giving one or more responses, creating one or more response curves. From this/these response curves is/are changes in the responses calculated as slope, curvatures or... Agent: Frishauf, Holtz, Goodman & Chick, PC

20090263825 - Methods, immunoassays and devices for detection of anti-lipoidal antibodies: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a solid support (such as a nitrocellulose membrane) is described. The ability to immobilize a... Agent: Klarquist Sparkman, LLP

20090263821 - Ubiquitin ligase assays and related reagents: The disclosure provides, inter alia, methods and reagents for use in measuring the attachment of ubiquitin and ubiquitin-like proteins to a target protein, particularly an E3 protein.... Agent: Ropes & Gray LLP

20090263828 - Novel assay for precursor t-cells having high proliferative capacity (phpc-asay): Diagnostic assay of antigen-specific T-cell precursors to determine the immunological status of patients suffering in chronic infectious diseases and to anticipate the disease progression and the response to therapy... Agent: The Law Offices Of Valerie E. Looper

20090263835 - Genes that are up- or down-regulated during differentiation of human embryonic stem cells: Genes that are up- or down-regulated during differentiation provide important leverage by which to characterize and manipulate early-stage pluripotent stem cells. Over 35,000 unique transcripts have been amplified and sequenced from undifferentiated human embryonic stem cells, and three types of differentiated progeny. Statistical analysis of the assembled transcripts identified genes... Agent: Geron Corporation Attn. David J. Earp

20090263836 - Botulinum toxin screening assays: Methods for detecting BoNT/A activity in a sample, methods for screening molecules able to compete with BoNT/A receptor binding, methods for reducing BoNT/A activity in a human and methods of marketing a neurotoxin capable of selectively binding to a FGFR2, a FGFR3, a SV2, or any combination thereof, to a... Agent: Allergan, Inc.

20090263829 - Alzheimer's disease biomarkers and methods of use: The invention encompasses biomarkers for AD, a method for detecting AD, a method of monitoring AD, and a kit for quantifying biomarkers for AD.... Agent: Polsinelli Shughart PC

20090263830 - Visualization and quantitiation of cellular cytotoxicity using cell-permeable fluorogenic protease substrates and caspase activity indicator markers: This invention provides a non-radioactive assay to monitor and quantify the target-cell killing activities mediated by cytotoxic T lymphocytes (CTLs). This assay is predicated on the discovery that apoptosis pathway activation and, in particular, caspase activity, provides a measure of cytotoxic effector cell activity. In one embodiment, measurement of CTL-induced... Agent: Weaver Austin Villeneuve & Sampson LLP

20090263833 - In vitro estimation of in vivo half-life binding proteins: The present invention discloses methods used to estimate the in vivo half-life of a binding protein of interest. The disclosed methods involve (a) determining for a binding protein of interest and for each of at least two different reference binding proteins an in vitro half-life using an in vitro protease... Agent: Kenneth P. Zwicker, Esq. Abbott Bioresearch Center

20090263832 - Reagents for the detection of protein phosphorylation in leukemia signaling pathways: The invention discloses nearly 123 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20090263831 - Ubiquitin ligase assay: The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.... Agent: Klarquist Sparkman, LLP

20090263834 - Droplet actuator devices and methods for immunoassays and washing: Droplet actuator devices and methods for immunoassays and washing are provided. According to one embodiment, a method of providing a droplet in contact with a surface of a super paramagnetic bead with a reduced concentration of a substance is provided and includes: (a) providing a super paramagnetic bead in contact... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20090263838 - Method for determining a lung cancer treatment and method for determining the effectiveness of an agent for treatment of lung cancer: The present invention provides a method of determining a lung cancer treatment, the method comprising: measuring an amount of KL-6 in a sample of body fluid from a subject, and determining the treatment based on the amount of KL-6 measured, and a method of determining the effectiveness of an agent... Agent: Taiyo Corporation

20090263837 - Method of minimizing reagent consumption in microplate-based reactions: A method is provided for performing a reaction, such as the synthesis of concentrated cDNA, in the wells of a microplate while minimizing the volume of the solution of reagents required to perform the reaction. In the method, a pestle is inserted into the well of a microplate to which... Agent: Knobbe Martens Olson & Bear LLP

20090263839 - Acetaminophen-protein adduct assay device and method: The present invention describes devices and methods for detecting and measuring the amount of acetaminophen-protein adducts in a sample.... Agent: Polsinelli Shughart PC

20090263840 - Novel monoclonal anitbody and use thereof: The present invention provides an antibody capable of specifically recognizing the same amino acid sequence as an antigenic determinant of mouse monoclonal antibody MAB-ME-16F4.3 (FERM BP-10329), and an antibody of capable of specifically recognizing the same amino acid sequence as an antigenic determinant of mouse monoclonal antibody MAB-ME-12C9.2 (FERM BP-10328),... Agent: Hogan & Hartson L.L.P.

20090263841 - Use of nnmt as a marker for lung cancer: The present invention relates to the assessment of lung cancer. It discloses the use of protein NNMT in the assessment of lung cancer. It also relates to a method for assessing lung cancer by measuring NNMT in vitro in a liquid sample derived from an individual. Measurement of NNMT can,... Agent: Roche Diagnostics Operations Inc.

20090263842 - Method of assessing the metastatic status of a primary tumor: The current invention provides a method for determining the metastatic potential, capability, status, or characteristics of a primary tumor from a human cancer patient by determining expression patterns of proteins that initiate, cause, promote, mediate, inflict, or otherwise aid metastatic properties of cells from a primary tumor. The identification of... Agent: Proskauer Rose LLP

20090263843 - Protein labeling with cyanobenzothiazole conjugates: The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting... Agent: Schwegman, Lundberg & Woessner, P.A.

20090263844 - Method and kit for quantitative determination for small, dense particle low density lipoproteins: A rapid and convenient method capable of performing fractional measurement of small, dense LDLs without pretreatment of a specimen, which is adaptable for an autoanalyzer, is provided. A method for quantitatively determining small, dense LDL cholesterol is provided, which comprises adding enzymes for cholesterol measurement to a test sample in... Agent: Foley And Lardner LLP Suite 500

20090263845 - Method and kit for assessing the suitability of erythrocytes for transfusion: A method of assessing whether or not erythrocytes are suitable for transfusion into a recipient comprising (i) assaying a sample of erythrocytes for free choline, and (ii) comparing the level of free choline in the sample with the level of free choline deemed suitable for transfusion therapies; and a kit... Agent: Paul D. Yasger Abbott Laboratories

20090263846 - Oxygen-resistant hydrogenases and methods for designing and making same: The invention provides oxygen-resistant iron-hydrogenases ([Fe]-hydrogenases) for use in the production of H2. Methods used in the design and engineering of the oxygen-resistant [Fe]-hydrogenases are disclosed, as are the methods of transforming and culturing appropriate host cells with the oxygen-resistant [Fe]-hydrogenases. Finally, the invention provides methods for utilizing the transformed,... Agent: Paul J White, Patent Counsel National Renewable Energy Laboratory (nrel)

20090263856 - Apparatus and method for detecting live cells with an integrated filter and growth detection device: A device for rapid concentration and detection of live cells in fluids includes a filter to capture a cell sample. The filter includes a first physical barrier with apertures of a first size and a second physical barrier with apertures of a second size smaller than the first size to... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090263849 - Bioprinting three-dimensional structure onto microscale tissue analog devices for pharmacokinetic study and other uses: A microfluidic system for monitoring or detecting a change in a parameter of an input substance, which includes a microfluidic device having a tissue chamber and a tissue analog placed in the tissue chamber, wherein the tissue analog has a vessel structure mimicking naturally occurring vessel network incorporated in the... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20090263855 - Compositions and methods for preventing or treating inflammatory bowel disease: Compositions comprising docosahexaenoic acid (DHA) and optionally one or more fatty acids selected from the group consisting of eicosapentaenoic acid (EPA), arachidonic acid (ARA), linoleic acid (LA), and α-linoleic acid (ALA) are administered to felines for preventing or treating feline inflammatory bowel disease (IBD).... Agent: Colgate-palmolive Company

20090263853 - High-throughput cell-based cftr assay: This invention provides a high throughput screen for measuring the transport of an ion through a cystic fibrosis transmembrane conductance regulator (CFTR) of a cell that endogenously expresses CFTR. The method requires culturing the cell that endogenously expresses CFTR in the presence of an ion-sensitive compound and then contacting the... Agent: Foley & Lardner LLP

20090263851 - In vivo selection system for enzyme activity: The present invention provides in vivo systems in which activity of a biological cleavage enzyme, such as a site-specific recombinase, a homing endonuclease, or an intein, is linked to cell viability and therefore can be selected. The invention further provides methods of making cells in which the activity of a... Agent: Choate, Hall & Stewart/harvard University

20090263854 - Integrated assay device and housing: A laminated, integrated, analyte assay device and methods of using the device are described. The assay device is useful as an inexpensive, disposable assay device for detecting the presence and/or amount of a particular analyte in a body fluid or other sample.... Agent: King & Spalding LLP

20090263847 - Lsr receptor, its activity, its cloning and its applications to the diagnosis, prevention and/or treatment of obesity and related risks or complications: The present invention relates to a new complex receptor polypeptide LSR (Lipolysis Stimulated Receptor), characterized by its functional activities, the cloning of the cDNAs complementary to the messenger RNAs encoding each of the subunits of the multimeric complex, vectors and transformed cells, methods of diagnosis and of selection of compounds... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090263850 - Method and system for measuring single cell mechanics using a modified scanning probe microscope: One embodiment of the present invention provides a system that measures single cell mechanics using a scanning probe microscope. During operation, the system positions a modified probe of the scanning probe microscope above a cell which is located on a surface, wherein the modified probe is configured with a geometry... Agent: Park, Vaughan & Fleming LLP

20090263848 - Method for determining the viability of cells in cell cultures: The invention relates to a method for determining the viability of cells in cell cultures, said method comprising the steps of: colouring the sample with a dye which can penetrate into individual cells depending on the viability of the latter, determining the proportions of cells which are coloured to differing... Agent: Casella & Hespos

20090263852 - Nonapoptotic forms of cell death and methods of modulation: The invention is directed to methods for identifying molecules that modulate paraptosis, a newly identified nonapoptotic form of programmed cell death. The invention also provides a method of inhibiting paraptosis by preventing association of caspase-9 and an endogenous paraptosis-mediating molecule. In one embodiment, the invention provides a method of inhibiting... Agent: Morrison & Foerster LLP

20090263857 - Method for antigen retrieval and submersion fluid compositions for use therein: The present invention relates to a method for retrieving the antigenicity of a formaldehyde-fixed sample for immunological staining and to compositions used in such a method. A method of the invention comprises submerging a sample in a submersion fluid composition comprising an osmotically active compound and heating the said submerged... Agent: Ladas & Parry LLP

20090263858 - Process for synthesis of mucin-type peptides and muc1-related glycopeptides: The invention aims at providing novel compounds useful as primer in producing mucin-type glycopeptides which are useful in a wide field including materials for biochemical research, drugs, and food and the production of which was difficult in the prior art; and a process for the production of glycopeptides by using... Agent: Seed Intellectual Property Law Group PLLC

20090263859 - Thermophilic and thermoacidophilic glycosylation genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for glycosylating and/or post-translationally of modifying proteins using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.... Agent: Traskbritt / Battelle Energy Alliance, LLC

20090263861 - Host-vector system antibiotic-free cole1 plasmid propagation: A host-vector system that uses the RNA-based copy number control mechanism of ColE1-type plasmids for regulating the expression of a marker gene allows for antibiotic-free selection of plasmids and is useful for production of plasmid DNA and recombinant proteins.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20090263863 - Modification of protein glycosylation in methylotrophic yeast: The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable of producing glycoproteins with mammalian-like glycosylation. Glycoproteins produced from the genetically engineered methylotrophic yeast strains are also provided.... Agent: Scully Scott Murphy & Presser, PC

20090263860 - Novel 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228,... Agent: Millennium Pharmaceuticals, Inc.

20090263862 - Novel alkane polyol dehydrogenase: e

20090263864 - Recombinant production of mixtures of antibodies: The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention... Agent: Traskbritt, P.C.

20090263865 - Substance specific to human pd-1: The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein... Agent: Sughrue-265550

20090263866 - Industrial-scale serum-free production of recombinant factor vii in mammalian cells: The invention provides a method for industrial-scale production of FVII polypeptides in mammalian cell culture free of animal-derived components.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20090263867 - Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin: A method for producing a chondroitin sugar chain comprises at least the following step: a step of allowing “a glucuronic acid donor”, “an N-acetyl galactosamine donor”, “a sugar receptor” and “a bacterial cell enzyme which synthesizes chondroitin” to coexist in a reaction system in the presence of a surfactant. Here,... Agent: Knobbe Martens Olson & Bear LLP

20090263868 - Nucleotide compositions comprising photocleavable markers and methods of preparation thereof: Labelled nucleotides and polynucleotides useful in the sequencing of nucleic acids are described. Methods of preparing photocleavable marker nucleotides and photocleavable marker-polynucleotide conjugates are described. Such photocleavable marker nucleotides can be incorporated into nucleic acid so as to create photocleavable marker-polynucleotide conjugates.... Agent: Medlen & Carroll, LLP Suite 350

20090263871 - Methods and compositions for amplification of dna: The invention provides an Enzyme Blend comprising a DNA polymerase and a DNA repair enzyme. Methods and kits for amplification of DNA that is damaged, undamaged, or suspected of being damaged are also provided.... Agent: Senniger Powers LLP (sgm)

20090263869 - Methods and compositions for pcr: A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula I wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3′-5′ exonuclease... Agent: Life Technologies Corporation C/o Intellevate

20090263870 - System and method for amplifying a nucleic acid molecule: There is provided a method and/or system which allow on-chip preconditioning of complex real-world samples and/or handling of limited amounts of target material, and/or on-chip nucleic acid amplification process, using a free droplet containing magnetic attractable material. The nucleic acid amplification process comprises controlling the position of the magnetic attractable... Agent: Dinsmore & Shohl LLP

20090263872 - Methods and compositions for preventing bias in amplification and sequencing reactions: The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include template nucleic acids with stabilizing sequences. The present invention also includes concatemers formed from template nucleic acids that have stabilizing sequences, arrays of such concatemers, as well... Agent: Morgan, Lewis & Bockius, LLP

20090263873 - Linear vectors, host cells and cloning methods: Linear vectors derived from bacteriophage of E. coli and host cells suitable for cloning are provided. The linear vectors include a left arm comprising a left telomere and a first selectable marker, a right arm comprising a right telomere and a second selectable marker and a cloning region located between... Agent: Michael Best & Friedrich LLP

20090263874 - L-glutamic acid-producing bacterium and method for producing l-glutamic acid: L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Enterobacter or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis or which decreases in or is deficient in... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090263875 - Methods of generating protein variants with altered function: The present invention provides methods of designing and generating polypeptide variants that have altered function compared to a parent polypeptide. The present invention further provides a computer program product for carrying out the design of a variant polypeptide. The present invention further provides nucleic acids encoding terpene cyclase variants, as... Agent: Bozicevic, Field & Francis LLP

20090263876 - Hydrogen fermentor and method of producing hydrogen: The hydrogen fermentation apparatus is the one that generates hydrogen by decomposing organic matter through hydrogen fermentation. There are arranged a hydrogen fermentor which holds the treating liquid containing organic matter, and a string-shape carrier which is positioned to immerse itself in the treating liquid in the hydrogen fermentor, and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090263877 - Method of fermentation: The invention provides a process for the production of biomass by culturing a microorganism in an aqueous liquid culture medium circulating in a loop reactor having an effluent gas removal zone where from carbon dioxide-containing effluent gas is removed from the reactor and upstream thereof a degassing zone in which... Agent: Sughrue Mion, PLLC

20090263878 - Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof: The present disclosure describes mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. The ELSCs of the present disclosure are capable of proliferating in an in vitro culture, maintain the potential to differentiate into cells of endoderm, mesoderm, and ectoderm lineage in culture, and are... Agent: Vinson & Elkins, L.L.P.

20090263879 - Immunoassay for specific determination of s-adenosylmethionine and analogs thereof in biological samples: This invention pertains to a method for detecting a compound in the presence of other compounds that are substantially similar in structure and metabolically related to the analyte. The invention is particularly suited for the detection of S-adenosylmethionine in the presence of S-adenosylhomocysteine, other nucleosides and derivatives in a biological... Agent: Isac A. Angers Suite 301

20090263880 - Mutant luciferase: An object of the present invention is to provide a mutant luciferase having luciferase activity with an altered emission spectrum. A specific amino acid residue(s) is substituted in a luciferase derived from Cypridina noctiluca and then the resulting mutant luciferase having luciferase activity with an emission spectrum differing from that... Agent: Sughrue Mion, PLLC

20090263881 - Alpha-amylase mutants: The invention relates to a variant of a parent Termamyl-like α-amylase, which exhibits an alteration in at least one of the following properties relative to said parent α-amylase: i) improved pH stability at a pH from 8 to 10.5; and/or ii) improved Ca2+ stability at pH 8 to 10.5, and/or... Agent: Novozymes North America, Inc.

20090263882 - Thermostable neutral metalloproteases: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus... Agent: Kamrin T. Macknight Danisco US Inc., Genencor Division

20090263883 - Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from respiratory syncytial virus: The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products... Agent: Medimmune, LLC Patrick Scott Alban

20090263884 - Multi-action drain cleaning composition and method: The present invention relates to aspects of drain cleaning compositions, methods, and systems involving multiple levels of attack to facilitate decomposition of clogs in pipe systems. Aspects of the invention relate to a multi-action drain cleaning composition including chemical and biological components capable of producing an exothermic reaction, an oxidation... Agent: Duane Morris LLP - PhiladelphiaIPDepartment

20090263885 - Process for producing trans-4-hydroxy-l-proline: The present invention is directed to a process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090263886 - Farnesyl dibenzodiazepinone and processes for its production: This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in... Agent: Merchant & Gould PC

20090263887 - Identification, characterization, and application of pseudomonas stutzeri (lh4:15), useful in microbially enhanced oil release: The present disclosure relates to isolation and identification of unique Pseudomonas stutzeri strains that can grow on crude oil under denitrifying conditions and are useful in oil recovery.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090263888 - Koji mold-origin phospholipase a2: It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived... Agent: Edwards Angell Palmer & Dodge LLP

20090263889 - Method for increasing yield of biomass of and/or components of biomass from marine microorganisms: The present invention provides an optimized method of continuously culturing an auxotrophic marine microorganism in a fermentor under aerobic conditions at Y g/l of cell dry matter, CDM, wherein Y is in the range from 100-300 g/l, comprising culturing said auxotrophic marine microorganism in a culture medium comprising a carbon... Agent: Novozymes North America, Inc.

20090263890 - Method and equipment for reducing environmental pollution: The invention relates to a method and equipment for reducing atmospheric pollution levels, reducing the concentration of fine dust and nitric oxides. The de-polluting system is based on a synergetic combination of nitrifying and denitrifying microorganisms on suitable supports. The product can be used internally and externally, at urban and... Agent: David A. Guerra International Patent Group, LLC

20090263891 - Device for analyzing samples including a gas evolving means: The invention relates to a device for analyzing one or more samples for the presence, amount or identity of one or more target molecules in the samples, comprising one or more capture sites whereby the device comprises a gas evolving means. The gas evolved by the gas evolving means moves... Agent: Philips Intellectual Property & Standards

20090263892 - Float valve for cell culture vessel: A cell culture vessel includes a housing defining a reservoir, an inlet and an outlet in fluid communication with the reservoir, a valve assembly, and an antimicrobial filter. The valve assembly includes (i) a side wall defining a passageway for fluid flow between the reservoir and the outlet, (ii) a... Agent: Corning Incorporated

20090263893 - Flexible membrane valve for cell culture vessel: An assembly for culturing cells includes a housing defining a reservoir for containing cell culture media and an opening in fluid communication with the reservoir. The cell culture assembly further includes a filter valve assembly configured to sealingly engage the opening. The filter valve assembly includes a flexible membrane, a... Agent: Corning Incorporated

20090263894 - Antibodies that bind to mammalian ngal and uses thereof: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.... Agent: Paul D. Yasger Abbott Laboratories

20090263895 - Cell line for producing a non-retroviral vector: Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include one or more native... Agent: Enzo Biochem, Inc.

20090263896 - Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells: The present disclosure relates to compositions and methods comprising cell surface markers for hES-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hES cells.... Agent: Knobbe Martens Olson & Bear LLP

20090263897 - Reishi f3 sub fraction polysaccharides and methods of using same: The present disclosure relates to the discovery of methods of isolating subfractions of an F3 Reishi extract, and of administration of these novel isolates to eukaryotic cells in order to induce certain immumodulatory, hematopoeitic and tumor-inhibiting phenotypic changes in those eukaryotic cells, mediated through particular toll-like receptor (TLR) and other... Agent: Greenberg Traurig LLP (la)

20090263898 - Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, methods for amplification of nucleic acids and methods for delivery of the chromosomes to selected cells and tissues are... Agent: K&l Gates LLP

20090263899 - Cell modification method and cell modification device: The present invention relates to a cell modification method for modifying human or mammal immune cells, especially effector cells outside the human or mammal body, wherein in a first step at least one encapsulated substance, preferably an active pharmaceutical ingredient, is introduced in and/or arranged on isolated human or mammal... Agent: Millen, White, Zelano & Branigan, P.C.

20090263900 - Linear donor constructs for targeted integration: Disclosed herein are linear donor molecules comprising homology arms of 50-750 base pairs (e.g., 50-100 base pairs) flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest... Agent: Robins & Pasternak

20090263901 - Stable neural stem cell lines: A systematic and efficient method for establishing stable neural stem cell lines and neuronal progenitor lines is described. The resulting cell lines provide robust, simple, and reproducible cultures of human and other mammalian neurons in commercially useful mass quantities while maintaining normal karyotypes and normal neuronal phenotypes.... Agent: K&l Gates LLP

20090263902 - Method for regulating agrobacterium-mediated transformation: A method for regulating expression of a virulence gene of Agrobacterium is described. The method comprises the steps of stimulating cereal cells, such as sorghum, so as to produce an active, typically phenolic, compound and exposing the Agrobacterium to this compound. The compound induces expression of the virulence gene of... Agent: Morrison & Foerster LLP