|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiologyBelow are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 12/05/2013 > 136 patent applications in 71 patent subcategories.
20130323708 - Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same: One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an... Agent: The General Hospital Corporation
20130323709 - Treating heart tissue: Some embodiments of a system or method for treating heart tissue can include a catheter device that provides a user with the ability to perform a number of heart treatment tasks (before, during, and after a cardiac surgery or a percutaneous coronary intervention). In particular embodiments, the catheter device can... Agent: Miracor Medical Systems Gmbh
20130323711 - Apparatus and method for isolating leukocytes and tumor cells by filtration: The present invention provides novel apparatuses and methods for isolating or recovering a subset of blood cells such as leukocytes and/or circulating tumor cells from blood samples by filtration without changing the intracellular concentration of a therapeutic agent such as an anticancer drug. Contrary to the art, the apparatuses and... Agent:
20130323712 - Method and material for separating leukocytes or mononuclear cells: An object of the present invention is to provide a separation system and a separation material for efficiently separating white blood cells or mononuclear cells from a biological fluid containing blood cell components. White blood cells or mononuclear cells can be efficiently separated by contacting a biological fluid containing blood... Agent: Kaneka Corporation
20130323710 - Methods for inducing the differentiation of blood monocytes into functional dendritic cells: Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood into a plasma component containing proteins, a platelet component and a buffy coat component. A plastic treatment device is provided having plastic channels... Agent: Yale University
20130323713 - Sun tracking light distributor system having a v-shaped light distribution channel: A sun-tracking light distributor system for use in one of an open-ended system and a closed photo-bioreactor for a photosynthetic culture having an aqueous liquid. The sun-tracking light distributor system comprises two light distribution walls, provided at an angle and oriented to converge at a bottom end, the light distribution... Agent: Institut National D'optique
20130323714 - System and method for micro-aeration based fermentation: A method and apparatus for micro-aeration of large scale fermentation systems is provided. The micro-aeration system includes a fermentation reactor, a sparging apparatus, and a micro-aeration gas mixture delivered to the fermentation reactor via the sparging apparatus. The micro-aeration gas mixture is a very low oxygen concentration mixture comprising an... Agent:
20130323715 - Container storing freeze-dried biological sample: Embodiments of the invention relate to a container holding, and a method of storing, freeze-dried biological samples. In particular, there is provided a container holding a freeze-dried material comprising a biological sample, the container comprising a chamber having an upper portion and a lower portion, the chamber comprising a wall... Agent: Ge Healthcare Uk Limited
20130323718 - Methods for the characterization of microorganisms on solid or semi-solid media: The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic... Agent: Biomerieux, Inc.
20130323719 - New iridium-based complexes for ecl: Novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, for example in the electrochemiluminescence based detection of an analyte.... Agent: Roche Diagnostics Operations, Inc.
20130323717 - Repeat-chain for the production of dimer, multimer, multimer complex and super-complex: The present invention relates to a super-complex prepared by cross-binding between repeat-chain/multiple-monomer complexes, and a method for amplifying the effect of monomer through the formation of the said super-complex. Particularly, the repeat-chain/multiple-monomer complex is prepared by containing repeat-chains of binding domain having binding specificity to monomers as active ingredients, and... Agent:
20130323716 - Signal encoding and decoding in multiplexed biochemical assays: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of... Agent: California Institute Of Technology
20130323721 - Hepatocytes for in vitro genotoxicity tests: The invention relates to a method for carrying out genotoxicity tests of chemical, biological and physical active substances or agents with the aid of cell culture systems of proliferating physiologically active liver cells.... Agent: Medicyte Gmbh
20130323722 - Methods for high fidelity production of long nucleic acid molecules: In a method for generating a long nucleic acid molecule, nucleic acids immobilized on a surface and having overlapping complementary sequences is released into solution. The overlapping complementary sequences are hybridized to form hybridized nucleic acids, followed by extension or ligation of the hybridized nucleic acids to synthesize the long... Agent: Massachusetts Institute Of Technology
20130323723 - Solid support and method of recovering biological material therefrom: The present invention relates to solid supports that are used for the storage and further processing of biological materials. The invention is particularly concerned with solid supports which have at least one surface coated with a chemical mixture that enhances the recovery of the biological material from the support. Methods... Agent: Ge Healthcare Uk Limited
20130323724 - Chemiluminescence proximity nucleic acid assay: This invention relates to the detection and quantitation of target nucleic acids in a heterogeneous mixture in a Sample and the methods of use thereof. The detection system includes a chemiluminescent molecule, a chemiluminescent substrate, a dye that is light responsive when intercalated into nucleic acids and nucleic acids. This... Agent: Beacon Biotechnology LLC
20130323731 - Determination of the depth coverage of the fetal genome: Systems, methods, and apparatus for determining at least a portion of fetal genome are provided. DNA fragments from a maternal sample (maternal and fetal DNA) can be analyzed to identify alleles at certain loci. The amounts of DNA fragments of the respective alleles at these loci can be analyzed together... Agent: The Chinese University Of Hong Kong
20130323734 - Genetic determinants of prostate cancer risk: Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa), e.g., an American or Caribbean subject of African descent and of reducing their risk.... Agent:
20130323735 - Means and methods for investigating nucleic acid sequences: The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid.... Agent: Stichting Sanquin Bloedvoorziening
20130323730 - Method for determining ploidy of a cell: A method for determining the ploidy of a test genome is provided. In some embodiments, the method may comprises: a) obtaining a plurality of ratios for polymorphisms that are distributed throughout a test genome, wherein each of the ratios is a ratio of the measured copy number of uncut allele... Agent:
20130323727 - Method of designing primers, method of detecting single nucleotide polymorphisms (snps), method of distinguishing snps, and related primers, detectable oligonucleotides, and kits: A method of designing a primer for detecting a single nucleotide polymorphism (SNP), a method of detecting an SNP, a method of distinguishing SNPs, primers, detectable oligonucleotides, and kits.... Agent:
20130323728 - Methods and kits for detection of 5-hydroxymethylcytosine: The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosme (5hmC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g.,... Agent: Oslo Universitetssykehus Hf
20130323726 - Methods and materials using signaling probes: The present invention relates to methods of isolating cells, generating cell lines, and detecting RNAs in cells using signaling probes that produce a signal upon hybridization to a target sequence. Other methods that utilize the signaling probe include methods of detecting or quantifying the effect of an agent on RNAs... Agent: Chromocell Corporation
20130323733 - Methods of assessing a risk of developing necrotizing meningoencephalitis: Methods of using single nucleotide polymorphisms (SNPs), SNP haplotype block, and haplotype to predict whether or not a subject will develop necrotizing meningoencephalitis (NME) and probe sets that facilitate those methods are disclosed. In preferred forms, the subject is a canine species.... Agent: Translational Genomics Research Institute
20130323729 - Proximity ligation technology for western blot applications: The invention provides a method for detecting a biomolecular feature (a protein, protein complex, or modified protein such as a phosphorylated protein) by a modified Western blot type of assay, which method either electrophoretic gel separation followed by transfer, or direct spotting of a sample containing the biomolecular feature onto... Agent: Olink Ab
20130323732 - Single-particle analysis of particle populations: In certain embodiments, the invention provides methods and devices for assaying single particles in a population of particles, wherein at least two parameters are measured for each particle. One or more parameters can be measured while the particles are in the separate reaction volumes. Alternatively or in addition, one or... Agent: Fluidigm Corporation
20130323725 - Target enrichment and labeling for multi-kilobase dna: This disclosure provides a method comprising: a) clamping the top and bottom strands of a double stranded DNA molecule to produce a duplex in which the top and bottom strands are linked; b) denaturing the duplex to produce a denatured product; and c) renaturing the denatured product in the presence... Agent: Agilent Technologies, Inc.
20130323741 - Amplification system with spatial separation: An automated nucleic acid analysis method and analytical system are described comprising separate modules, wherein the air flow of any one of said modules is controlled and wherein at least the air flow between the module for isolation and purification of the analyte and the module for analysis of the... Agent: Roche Molecular Systems, Inc.
20130323738 - Detection of amplification products: Compositions and methods are provided for quantitative detection of amplification products, the methods being suitable for multiplexing. A first oligonucleotide that includes a primer sequence for priming an amplification reaction and also is labeled with a fluorescent label or quencher is mixed with a second oligonucleotide which has a sequence... Agent: New England Biolabs, Inc.
20130323740 - Direct blood assay for detection of circulating microrna in cancer patients: Methods of diagnosing, determining the progression, or determining a prognosis of a cancer in a subject are provided. Such methods may include steps of measuring a test level of one or more miR molecules in a biological sample from the subject; comparing the test level to a control level of... Agent:
20130323737 - Method and system for analyzing a sample: A method and system for analysing a sample are provided, wherein one or more process steps and/or sample processors are provided separately from the instrument, for instance a sample receiving step and sample preparation step and sample extraction step and sample retention step and/or purification step and washing step and... Agent: Bioaccel
20130323739 - Method for determining recurrence or stable disease after treatment for prostate cancer: This invention describes compositions and methods for use in PSA assays having low functional sensitivity which are useful, for example, in the detection of early stage recurrence of prostate disease following treatment and in the determination of whether patients have prostate cancer recurrence or stable disease.... Agent: Iris International, Inc.
20130323736 - Polynucleotide primers: A polynucleotide primer comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 1 to 18, 21 to 45 or 74 to 77.... Agent: Qiagen Manchester Limited
20130323743 - Rate based identification of reaction points: An apparatus for identifying transition points in a chemical reaction, the apparatus comprising: a property value receiver, configured to receive a plurality of values of a physical property of the chemical reaction, a function calculator, associated with the property value receiver, configured to calculate a function and verify that the... Agent:
20130323744 - Signatures and determinants associated with cancer and methods of use thereof: The present invention provides methods of detecting cancer using biomarkers.... Agent: Dana-farber Cancer Institute, Inc.
20130323742 - Systems and methods for enhanced nucleic acid seperation: Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or... Agent: The University Of British Columbia
20130323745 - Method of detecting viable cells in a cell sample: The invention relates to a method for determining the presence and/or amount of viable cells in a liquid sample.... Agent: Charles River Laboratories, Inc.
20130323746 - Genotoxicity as a biomarker for inflammation: The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease... Agent: The Regents Of The University Of California
20130323747 - Targeting and tracing of antigens in living cells: The present invention relates to a method of detecting the presence, amount or subcellular location of an antigenic structure of interest in a cell.... Agent: Ludwig-maximilians-universitat Munchen
20130323754 - Diagnostic kit as well as a metho dfor the examination of a human patient sample for the presence of neuromyelitis optica-specific antibodies: The solution described is characterized in that as said initial substrate, an aquaporin-4-containing native substrate is used as well as that said neuromyelitis optica-specific antibodies at least partially bound to said aquaporin-4-containing initial substrate are reacted with components of the complement system and the reaction of said complement system is... Agent: Euroimum Medizinische Labordiagnostika
20130323753 - Methods and kits for identification of anti-excitotoxic compounds: The instant invention provides methods and kits for screening for anti-excitotoxic compounds which increase the total amount of EAAT-1 protein or the surface amount of EAAT-1 protein.... Agent: Rutgers, The State University Of New Jersey
20130323755 - Diagnostic tumor markers, drug screening for tumorigenesis inhibition, and compositions and methods for treatment of cancer: The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1 cell proliferation are discussed.... Agent: Minerva Biotechnologies Corporation
20130323756 - Methods and compositions for quantifying exosomes: Embodiments of the present invention relate to methods, compositions and kits for quantifying exosomes. In particular, methods, composition and kits that utilize lectins to quantify exosomes are provided.... Agent: Aethlon Medical, Inc.
20130323749 - Granzyme a and granzyme b diagnostics: A method for identifying a subject being at risk for or having a chronic Inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the... Agent: The University Of British Columbia
20130323750 - Method for analyzing apoptosis inducing factor-2: A method for analyzing apoptosis inducing factor-2 (AIF-2) is disclosed, which has not been found in urine samples of human patients with chronic kidney disease, to establish AIF-2 as a non-invasive biomarker for chronic kidney disease. The method includes: collecting a plurality of urine samples; conducting western blot for each... Agent: National Taiwan University Hospital
20130323748 - Method of judging risk of cancer recurrence and computer program: There is provided a method of judging a risk of cancer recurrence based on the activity value and expression level of the first CDK, the activity value and expression level of the second CDK, and the expression levels of uPA and PAI-1 and a computer program.... Agent: Sysmex Corporation
20130323751 - Urine biomarkers for prediction of recovery after acute kidney injury: proteomics: This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, renal recovery. For example, renal recovery can be determined by monitoring urine biomarkers related to the development of chronic... Agent: University Of Pittsburgh - Of The Common-wealth System Of Higher Education
20130323758 - Measurement device and measurement method: A measurement device that includes a plurality of lines for conveying a reaction container containing a sample and measures a predetermined material included in the sample while conveying the reaction container by the plurality of lines, wherein the plurality of lines include: a first reaction line for conveying a reaction... Agent: Fujirebio Inc.
20130323752 - Blid; a novel protein domain for interaction with the bcl-2 family of proteins: In this invention, a novel protein interaction domain is provided along with several of its variants. This domain is involved in protein-protein interactions with the Bcl-2 family of proteins. It is named BLID (Bcl2 family of proteins Like Interaction Domain). Use of BLID and its variants for modulating cellular activity... Agent:
20130323762 - Anti-idiotype antibody against an antibody against the amyloid beta peptide: The present invention is directed to an anti-idiotype antibody binding to the complementary determining region of an antibody against the amyloid β peptide. In one embodiment said antibody binds to the same epitope or an overlapping epitope as the antibody obtainable from the cell line DSM ACC2939. Also reported is... Agent:
20130323761 - Biomarkers and therapeutic targets for treating cardiomyopathies and congestive heart failure: In alternative embodiments, the invention provides methods for predicting or diagnosing a heart disease or a defect in cardiac muscle contractility in an individual, or a defect in rate of cardiac muscle twitch relaxation and/or ventricular torsion, or detecting a cardiac trauma, in an individual or in a cardiac cell,... Agent: The Regents Of The University Of California
20130323760 - Composition of diagnostic biomarker for stomach cancer and method of diagnosing stomach cancer using the composition: Provided are a composition of a diagnostic biomarker for stomach cancer and a method of diagnosing stomach cancer using the same. The composition of a diagnostic biomarker for stomach cancer and the method of diagnosing stomach cancer using the same may be useful to determine stomach cancer from a patient... Agent: Korea Institute Of Science And Technology
20130323763 - Method for diagnosing acute lung injury: The present invention provides a useful examination method and diagnostic reagent, which are capable of diagnosing acute lung injury in clear distinction from chronic progressive interstitial pneumonia. Specifically, the present invention provides a method of determining whether or not a test subject is affected with acute lung injury, which comprises... Agent: Nagasaki University
20130323759 - Spinal muscular atrophy diagnostic methods: The present invention relates to the discovery of the human survival motor-neuron gene or SMD gene, which is a chromosome 5-SMA (Spinal Muscular Atrophy) determining gene. The present invention further relates to the nucleotide sequence encoding the SMN gene and corresponding amino acid sequence, a vector containing the gene encoding... Agent: Institut National De La Sante Et De La Recherche Medicale
20130323764 - Assay test card: The present invention relates to the use of surfaces that exhibit different surface energies wherein the difference in surface energies is configured to disrupt capillary laminar flow of a fluid travelling between the two surfaces. The invention further relates to the use of such surfaces in assay methods including a... Agent: L3 Technology Limited
20130323765 - Method for determining the activity of a proteolytic coagulation factor in a sample: A method for determining the activity of a proteolytic coagulation factor in a sample may include (a) providing and incubating a reaction mixture comprising (i) the sample, (ii) an agent for direct or indirect activation of the proteolytic coagulation factor in the sample, (iii) a cleavable substrate which has at... Agent:
20130323767 - Method to identify liver toxicity using metabolite profiles: The present disclosure relates to a methodology that identifies the underlying mechanisms that lead to hepatotoxicity. This is done by using the alterations in cellular metabolite profiles obtained before and after therapy/drug treatment in combination with a model of liver metabolism. Subsequently, by using a covariance matrix adaptation followed by... Agent: Strand Life Sciences Private Limited
20130323766 - Production of malonyl-coa derived products via anaerobic pathways: The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or... Agent: Mascoma Corporation
20130323768 - Culture substrate comprising cellulose gel, solid medium using same, and cellulase activity assay method using medium: A cellulose gel medium having good visibility of microbial colonies, a cellulose gel culture substrate for manufacturing the cellulose gel medium, a method for manufacturing the cellulose gel culture substrate, a method for screening cellulase-producing microorganisms or cellulase activity with greater efficiency and rapidity, and a culture substrate, which includes... Agent: Kyokuto Pharmaceutical Industrial Co., Ltd.
20130323769 - Endoplasmic reticulum calcium atpase kinetics indicator and use thereof: The present invention provides a fusion protein including sarco/endoplasmic reticulum calcium ATPase, a fluorescence donor for FRET, and a fluorescence acceptor, one of the fluorescence donor and the fluorescence acceptor being linked to the N-terminus side of the ATPase, the other of the fluorescence donor and the fluorescence acceptor being... Agent: Riken
20130323770 - Substrates and methods for staining live stem cells: The invention relates to novel substrates and methods for staining live stem cells. The stain may be used to identify induced pluripotent stem cell colonies during the process of somatic cell reprogramming.... Agent: Life Technologies Corporation
20130323771 - Copolymer-1, process for preparation and analytical methods thereof: The present invention relates to analytical methods such as molecular weight determination of polypeptide, in particular Glatiramer acetate. The present invention further relates to an improved process for preparation of polypeptides or pharmaceutically acceptable salts thereof, particularly Glatiramer acetate also known as Copolymer-1. The present invention further relates to characterization... Agent: Usv Limited
20130323772 - 3-hydroxypropionic acid and other organic compounds: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.... Agent: Cargill, Incorporated
20130323776 - Carrier peptide fragment and use thereof: A method for transferring a foreign substance includes: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including any amino acid sequence selected from SEQ ID NOS: 1-6, or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or... Agent:
20130323777 - Compact multifunctional ligand to enhance colloidal stability of nanoparticles: A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing... Agent: Naval Research Laboratory
20130323775 - Device for incubating a sample: The field of the invention relates to a device for incubating a sample. The present disclosure provides an incubator for shaking and/or heating at least one sample. The device comprises at least one inductor placed below an induction heating plate. A heat conducting plate is mounted onto the induction heating... Agent:
20130323774 - Homogenous and fully glycosylated human erythropoietin: The present invention provides homogenous, fully-glycosylated, full length erythropoietin and the methods of producing the same.... Agent: Sloan-kettering Institute For Cancer Research
20130323773 - Processes and kits for determining multi-drug resistance of cells: This invention relates to multi-drug resistance (MDR) in cells, and the use of certain xanthene compounds for determining drug resistance in cells and the effect of test compounds on cell membrane transport by the membrane transporters MDR1, MRP and BCRP. Processes and kits for making these determinations and measuring these... Agent:
20130323778 - Paper support and method of recovering biological material therefrom: The present invention relates to paper supports for neonatal screening that are used for the storage and further processing of biological materials. The invention is particularly concerned with paper supports which have at least one surface coated with a chemical that enhances the recovery of the biological material from the... Agent: Ge Healthcare Uk Limited
20130323779 - Lighting systems and methods of using lighting systems for in vitro potency assay for photofrin: Presently disclosed is a lighting system and methods of using the lighting system for in vitro potency assay for photofrin. The lighting system includes a lamp housing, a first lens, an infrared absorbing filter, an optical filter, and a second lens. The lamp housing includes a lamp and a light-port.... Agent: Pinnacle Biologics, Inc.
20130323781 - Device for detecting a fungal contamination: The present invention relates to a device for detecting a fungal contamination in an internal environment, to the use thereof and also to a method for detecting a fungal contamination in an internal environment using such a device.... Agent: Centre Scientifique Et Technique Du Batiment (cstb)
20130323782 - Method of generating induced pluripotent stem cells and differentiated cells: Methods for generating iPSCs and differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCs or by direct reprogramming the urine cells.... Agent: Universitat Fur Bodenkultur Wien
20130323780 - Promoters and terminators for use in eukaryotic cells: The present invention provides novel promoter and terminator sequences for use in heterologous gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a heterologous gene. The invention further provides expression vectors and host eukaryotic cells,... Agent: Exxonmobil Research And Engineering Company
20130323783 - Alkaline feed: A method for cultivating a bacterial cell comprising the addition of an amino acid in an alkaline solution used for pH regulation. Also an aspect is a method for producing a polypeptide comprising the steps of a) providing a bacterial cell comprising a nucleic acid encoding the polypeptide, b) cultivating... Agent:
20130323784 - Process for producing target substance by fermentation process: A target substance can be efficiently produced by culturing, in a medium, a coryneform bacterium in which the activity of a PTS protein relating to fructose uptake is reduced or lost as compared with a parent strain and the bacterium can produce the target substance, allowing the target substance to... Agent: Kyowa Hakko Bio Co., Ltd.
20130323785 - Method for producing human epidermal growth factor in large volume from yeast: The present invention relates to a method for producing hEGF (human epidermal growth factor) which has the same activity as the wild form, in high concentration and with a high degree of purity. More specifically, the invention relates to an hEGF expression vector comprising a nucleic acid sequence coding for... Agent: Korea Research Institute Of Bioscience And Biotechnology
20130323789 - Anti system asc amino acid transporter 2 (asct2) antibody: An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (ASCT2) or a method using the antibody. The present invention provides a monoclonal antibody which specifically recognizes a native three-dimensional structure... Agent: Kyowa Hakko Kirin Co., Ltd
20130323786 - Composition comprising antibodies to lingo or fragments thereof: Endogenous LINGO-1 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous LINGO-1 function, such anti-LINGO-1 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for LINGO-1, and methods of using such... Agent: Biogen Idec Ma Inc.
20130323787 - Phage displaying system expressing single chain antibody: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal... Agent:
20130323788 - Production cell line enhancers: The present invention relates to discovery of the ectopic expression of EDEM2 in a production cell to improve the yield of a useful multi-subunit protein. Thus, the present invention provides for production cell lines, such as the canonical mammalian biopharmaceutical production cell—the CHO cell, containing recombinant polynucleotides encoding EDEM2. Also... Agent: Regeneron Pharmaceuticals, Inc.
20130323790 - Human lambda light chain mice: Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an... Agent: Regeneron Pharmaceuticals, Inc.
20130323791 - Restricted immunoglobulin heavy chain mice: Mice having a restricted immunoglobulin heavy chain locus are provided, wherein the locus is characterized by a single polymorphic human VH gene segment, a plurality of human DH gene segments and a plurality of JH gene segments. Methods for making antibody sequences that bind an antigen (e.g., a viral antigen)... Agent: Regeneron Pharmaceuticals, Inc.
20130323793 - Compositions and methods for reducing background dna amplification: Compositions are provided that include a plurality of small molecules selected from the group consisting of an amide, urea or acetone having a molecular weight less than 300 g/mol; and dNTPs and a polymerase in a buffer suitable for use as an amplification buffer. Methods of use of the compositions... Agent: New England Biolabs, Inc.
20130323795 - Endonuclase-assisted isothermal amplification using contamination-free reagents: Disclosed are methods and kits for endonuclease-assisted DNA amplification reaction using decontaminated primer solutions that are pre-treated with a nuclease. Nucleic acid amplification assays that employ nuclease-resistant, inosine-containing primers, endonuclease V enzymes to introduce a nick into a target DNA comprising at least one inosine, and a DNA polymerase to... Agent: General Electric Company
20130323792 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent: The Penn State Research Foundation
20130323794 - Recombinational cloning using engineered recombination sites: Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have the desired characteristic(s) and/or DNA segment(s).... Agent: Life Technologies Corporation
20130323797 - Methods and reagents for molecular cloning: The present invention provides compositions, methods, and kits for covalently linking nucleic acid molecules. The methods include a strand invasion step, and the compositions and kits are useful for performing such methods. For example, a method of covalently linking double stranded (ds) nucleic acid molecules can include contacting a first... Agent: Life Technologies Cororation
20130323796 - Methods and compositions for synthesis of nucleic acid molecules using multiplerecognition sites: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination .sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the... Agent: Life Technologies Corporation
20130323798 - Method of using alpha-amylase from aspergillus clavatus for saccharification: A fungal α-amylase is provided from Aspergillus clavatus (AcAmyl). AcAmyl has an optimal pH of 4.5 and is operable at 30-75° C., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction. This obviates the necessity of running a saccharification reaction as a batch process,... Agent: Danisco US Inc.
20130323799 - Method for industrially producing cyclic-structure-containing branched glucan: An object of the present invention is to provide a method for industrially producing a branched glucan having a cyclic structure. The method for producing a branched glucan having a cyclic structure comprises the steps of: (1) preparing a mixed liquid which contains a branching enzyme in which starch granules... Agent: Ezaki Glico Co., Ltd.
20130323800 - Method for producing cadaverine: A method produces cadaverine more efficiently and at a higher yield than production methods by the conventional fermentation methods. The method includes culturing coryneform bacterium/bacteria having an ability to produce cadaverine and having a resistance to 2,2′-thiobis(ethylamine). Preferably, the coryneform bacterium/bacteria has/have lysine decarboxylase activity and, preferably, the coryneform bacterium/bacteria... Agent: Toray Industries, Inc.
20130323801 - Compositions, methods, and kits for polyunsaturated fatty acids from microalgae: The present invention provides compositions, methods, and kits comprising PUFAs produced by microalgae, in particular omega-3 and/or omega-6 fatty acids produced by members of the genus Rhodomonas, in particular Rhodomonas salina and/or genetically engineered bacteria or co-cultures of microalgae and bacteria. The invention also provides compositions, methods, and kits comprising... Agent: Wake Forest University School Of Medicine
20130323802 - Method for producing oil by yeast: A method for producing oil in a form of triglyceride is provided. The method comprises steps of providing a carbon source and a nitrogen source; and culturing a yeast strain of Pseudozyma pruni with the carbon source and the nitrogen source to produce the oil.... Agent:
20130323803 - Methods and compositions for the production of extremophile enzymes from green microalgae and cyanobacteria: The present invention relates to compositions and methods for stable transformation of green microalgae and for production of transgenic green microalgae and/or cyanobacteria that produce extremophile enzymes as co-products during the growth of the green microalgae and/or cyanobacteria for lipid biofuel production. Thus, the present invention provides nucleic acid constructs... Agent: North Carolina State University
20130323804 - Method to produce phbv by recombinant escherichia coli: The invention discloses a method for production of polyhydroxybutyrate-co-polyhydroxyvalerate (PHBV) by recombinant Escherichia coli harboring plasmid containing both phaCAB and prpE. Different percentage of hydroxyvalerate can be obtained from the recombinant E. coli when cultivated in the medium containing different concentrations of propionic acid. In this patent, we provide a... Agent: Yuan Ze University
20130323805 - Production method for chemicals by continuous fermentation: A method of producing chemicals through continuous fermentation includes washing a membrane with a washing liquid supplied from a permeate side of a membrane unit in a continuous fermentation; filtering a culture medium containing a fermentation feedstock, a chemical and a microbe or a cultured cell through a separation membrane;... Agent: Toray Industries, Inc.
20130323807 - 3-hydroxypropionic acid and other organic compounds: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.... Agent: Cargill, Incorporated
20130323806 - Recombinant microorganisms and uses therefor: Bacteria are genetically engineered to produce 3-hydroxypropionate (3-HP). The bacteria are carboxydotrophic acetogens. The bacteria produce acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/CO2. A malonyl-coA reductase from a bacterium that contains such an enzyme is introduced. Additionally, an acetyl-coA carboxylase may also be introduced The production of 3-HP can... Agent: Lanzatech New Zealand Limited
20130323808 - 3-hydroxypropionic acid and other organic compounds: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.... Agent: Cargill, Incorporated
20130323809 - Metabolic engineering of clostridium tyrobutyricum for butanol production: This invention relates to compositions, systems, and methods for producing biofuels, such as butanol, and related compounds. More specifically, provided are methods of making recombinant microorganisms having non-naturally occurring metabolic pathways for the production of biofuels, and methods of producing biofuels using such organisms. Also provided are metabolically engineered microorganisms... Agent: The Ohio State University
20130323810 - Biological method for liquid ferric sulfate manufacturing: The present document describes a process for manufacturing liquid ferric sulfate from an iron sulfide material provided from ore tailings or mine tailings, the process comprising the step of contacting an aqueous solution containing the iron sulfide material with a thermotolerant bacteria culture capable of promoting oxidation of the iron... Agent: Bactech Environmental Corporation
20130323811 - Biopolymer sensor and method of manufacturing the same: A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor... Agent: Tufts University
20130323812 - In situ restoration of apatite-based chromatography resins: Methods and compositions are provided for treatment of an apatite-based resin from which retained solutes have been eluted by an elution buffer that contains an alkali metal salt with solutions of calcium ion, phosphate ion, and hydroxide separately from any sample loading and elution buffers. The treatment solutions restore the... Agent: Bio-rad Laboratories, Inc.
20130323813 - Peptides for the specific binding of rna targets: A recombinant polypeptide is described including at least one PUF RNA-binding domain capable of specifically binding to a cytosine RNA base. The PUF RNA-binding domain of the polypeptide includes at least one RNA base-binding motif of the general formula X1X2X3X4X5X6X7X8X9X10X11 wherein X1 is selected from a defined group and wherein... Agent: The University Of Western Australia
20130323814 - Method for highly sensitive detection of protein-protein interaction: The present invention intends to provide an assay system using split luciferase that has a remarkably high detection sensitivity. In an embodiment, binding of mutually binding first and second proteins is detected by preparing a first fusion protein comprising the first protein fused with a peptide having the amino acid... Agent: Probex Inc.
20130323815 - Fungal nucleic acid extraction: The invention provides methods for extraction of fungal (e.g., yeast spp., filamentous fungal spp.) nucleic acid (e.g., DNA, RNA) from a sample (e.g., be human or veterinary clinical or research samples, agricultural samples, agricultural commodity samples, food products, or environmental samples). In some embodiments, the present invention provides enhanced nucleic... Agent: Ibis Biosciences, Inc.
20130323816 - Protease variants active over a broad temperature range: The present invention provides protease compositions particularly suited for dishwashing applications.... Agent: Danisco US Inc.
20130323817 - Compositions and methods for the production of recombinant virus vectors: A method for the production of a replication-deficient recombinant virus vector is disclosed. The replication-deficient recombinant virus vector has a recombinant virus genome with one or more defective viral genes. The method comprises infecting a host cell with a carrier virus having a carrier virus genome encoding one or more... Agent:
20130323818 - Novel thermophilic bacterium and uses of extracellular proteins therefrom: A novel thermophilic bacterium is provided, which has a 16S rDNA sequence as set forth in SEQ ID NO. 1. The thermophilic bacterium excretes extracellular proteins having excellent metal-ion binding ability, being useful in the treatment of boiler equipment, pipelines, geothermal wells or industrial wastewater or hard water.... Agent: Industrial Technology Research Institute
20130323819 - Expression of antibody or a fragment thereof in lactobacillus: Described herein are methods and compositions for expressing an antibody or a fragment thereof in a microorganism and use of the microorganism to treat or prevent a pathogenic infection in a mammal.... Agent:
20130323820 - Recombinant microorganisms and uses therefor: Terpenes are valuable commercial products used in a diverse number of industries. Terpenes may be produced from petrochemical sources and from terpene feed-stocks, such as turpentine. However, these production methods are expensive, unsustainable and often cause environmental problems including contributing to climate change. Microbial fermentation provides an alternative option for... Agent: Lanzatech New Zealand Limited
20130323821 - Non-natural amino acid replication-dependent microorganisms and vaccines: Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.... Agent: Ambrx, Inc.
20130323822 - Yeast expressing saccharolytic enzymes for consolidated bioprocessing using starch and cellulose: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose... Agent: Mascoma Corporation
20130323823 - Tailored oils: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced... Agent: Solazyme, Inc.
20130323824 - Control device for a food waste disposal apparatus: This invention relates to a control device for a food waste disposal apparatus. The control device is comprised of a touch screen, a memory device to perform a specific function to control the food waste disposal apparatus. The touch screen of the control device displays a plurality of input button... Agent:
20130323826 - Amplification system with spatial separation: An automated nucleic acid analysis method and analytical system are described comprising separate modules, wherein the air flow of any one of said modules is controlled and wherein at least the air flow between the module for isolation and purification of the analyte and the module for analysis of the... Agent: Roche Molecular Systems, Inc.
20130323827 - Biochip including conductive particle and device for detecting target antigen comprising the same: A biochip including conductive particle and a device for detecting target antigen comprising the biochip are disclosed. According to the present invention, a target antigen can be effectively detected using a small amount of target antigen alone, whereby nonspecific detection signal can be reduced and an amplified signal can be... Agent: Lg Electronics Inc.
20130323825 - Information processing apparatus, information processing method, and program: Provided is an information processing apparatus, including a testing section performing statistical testing on simple staining data obtained by performing fluorescence measurement on a particle subjected to simple staining with a staining material having a prescribed fluorescence characteristic and unstaining data obtained by performing fluorescence measurement on an unstained particle... Agent: Sony Corporation
20130323828 - Urine test sheet: A urine test sheet which can reduce the workload of a person performing a test through the use of a urine test sheet, caused by the above-mentioned temporary restriction and which makes it possible to obtain a determination result having high reliability. The urine test sheet includes a support, and... Agent:
20130323829 - Biological sample holder and method of assembling same: Embodiments of the invention relate to a biological sample holder and for holding biological samples. Conventionally, processing of biological samples, which may be stored on a biological sample storage medium, is done manually with samples being tested individually. However, handling of the samples is difficult and time consuming; greater demand... Agent: Ge Healthcare Uk Limited
20130323830 - Ensiling biomass for biofuels production and multiple phase apparatus for hydolyzation of ensiled biomass: A method, apparatus and system for the hydrolyzation of ensiled biomass is disclosed. Ensiled biomass is processed in multiple phases, resulting in a liquid precursor hydrozate and a solid precursor hydrozate. The liquid precursor having significant economic value, and being suitable for uses such as, for example, lower cost and... Agent:
20130323831 - Integrated versatile kit for isolating components in biological samples: The instant invention provides an intergrated kit with solutions and instruments to isolate various biological samples from biological samples. The kit enables an user to preserve specimens and isolate biomolecules with features and benefits of high quality, easy, fast, no toxicity, safe to user and environment, low demanding, cost-effective, reducing... Agent: Bexmart
20130323832 - Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance: The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to... Agent: Georgia Health Sciences University
20130323833 - Reprogramming cells: The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3′-phosphoinositide-dependent kinase-1 (PDK1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.... Agent:
20130323834 - Methods for inducing selective apoptosis: Provided herein are methods for cell therapy by modifying transfused cells to express an inducible caspase 9 protein, so that the cells may be selectively killed if the patient experiences dangerous side effects. Provided also within relates in part to methods for preventing or treating Graft versus Host Disease by... Agent: Bellicum Pharmaceuticals, Inc.
20130323836 - 5'-end derivatives: The present invention provides compounds of formula (1). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time... Agent: Isis Pharmaceuticals, Inc.
20130323837 - Defined systems for epithelial cell culture and use thereof: The present invention provides cell culture media formulations which support the in vitro cultivation of animal epithelial cells. The media comprise at least one fibroblast growth factor (FGF) and at least one agent that induces increased intracellular cAMP levels, and optionally comprise ascorbic acid. The present invention also provides methods... Agent: Life Technologies Corporation
20130323835 - Mammalian genes involved in infection: The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.... Agent: Zirus, Inc.
20130323838 - Triggered rnai: The present application relates to methods and compositions for triggering RNAi. Triggered RNAi is highly versatile because the silencing targets are independent of the detection targets. In some embodiments, methods of silencing or modulating the expression of a target gene are provided. The methods generally comprise providing an initiator to... Agent: California Institute Of Technology
20130323839 - Culture substrate and culture sheet: Provided is a culture sheet which enables a technique for forming a three-dimensional tissue having uniform diameter without applying any chemical on the surface of a culture substrate. On the culture sheet (150) of the culture substrate, a plurality of holes (152) are formed and nanopillars (153), which are capable... Agent: Hitachi, Ltd.
20130323840 - Cylinder channel having a sawtooth-shaped cross section, coaxial channel including same and method for manufacturing same: The present disclosure relates to a cylinder channel having a sawtooth-shaped cross section, a method for manufacturing same, a coaxial channel including same and a method for manufacturing a microfiber or a microparticle having a sawtooth-shaped cross section using same.... Agent: Korea University Research And Business Foundation
20130323842 - Artificial tissue construct and method for producing the same: An object of the present invention is to provide an artificial tissue construct that has means for transporting nutrients, oxygen, waste products, or the like and is viable in vivo. The present invention relates to a tissue construct formed in vitro, which comprises a vascular layer, a basal membrane layer,... Agent: Dai Nippon Printing Co., Ltd.
20130323841 - Dynamically alterable cell support: A dynamically alterable cell support may be altered at a large scale to induce mechanical removal of adherent cells in culture without the use of a removal solution. For example, adherent cells may be cultured on an elastic support with one or more textured surface regions and removed by expansion/contraction... Agent: Empire Technology Development LLC
20130323843 - Polyphenol production by vaccinium myrtillus cell cultures: Cell cultures of Vaccinium myrtillus configured to grow in suspension culture in a liquid medium. The cells are derived from one or more V. myrtillus plant parts, such as an edible plant part (e.g., a leaf part or a berry part) or a stem part. The cells are adapted to... Agent:11/28/2013 > 133 patent applications in 69 patent subcategories.
20130316326 - Animal model for the evaluation of the efficacy of an hiv vaccine: The present invention relates to the use of a Severe Combined T-B-Immune Deficient (SCID) mouse engrafted with human immunocompetent cells (Hu-SCID-mouse) as an animal model for the evaluation of the effectiveness of an HIV vaccine. Furthermore, the present invention relates to a method for the evaluation of an HIV vaccine,... Agent: Technologie Integrale Ltd.
20130316328 - Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup: The present invention provides rapid and accurate methods, primers, probes and kits for identifying the presence of a certain flaviviruses in a sample. Flaviviruses that can be detected include members of the Japanese encephalitis virus serogroup, Dengue virus, St. Louis encephalitis virus, Montana myotis leukoencephalitis virus, Modoc virus, and Yellow... Agent: Roche Molecular Systems, Inc.
20130316331 - Detection of infection by a microorganism using small rna sequencing subtraction and assembly: There is provided a method for the detection and identification of infection of a subject by a microorganism, wherein the method is based on the use of small RNA derived sequences and subtraction and assembly thereof.... Agent: Ramot At Tel-aviv University Ltd.
20130316333 - Method for detecting and quantifying microorganisms: The present invention relates to a method for detecting at least one microorganism in a sample, including: cultivating the sample in a liquid medium in the presence of at least one specific ligand of the microorganism, and at least one scavenger having a lower affinity to the microorganism than the... Agent: Commissariat A L'energie Atomique Et Aux Energies Alternatives
20130316329 - Micro-devices for disease detection: Among others, the present invention provides piezo-electric micro-devices for detecting at the microscopic level an electric, magnetic, electromagnetic, thermal, optical, acoustical, biological, chemical, physical, bio-chemical, bio-physical, physical-chemical, bio-physical-chemical, bio-mechanical, bio-electro-mechanical, electro-mechanical, or mechanical property of the biologic subject.... Agent:
20130316327 - Nmr diagnostics by means of a plastic sample container: Sample containers and methods for employing the same in in-vitro nuclear magnetic resonance measurements are provided. The sample containers are made of a material that comprises on or more polymeric materials.... Agent: T2 Biosystems, Inc.
20130316330 - Non-toxic solvent for chromogenic substrate solution and uses thereof: The present invention relates to a non-toxic dipolar solvent for chromogenic substrate for detecting presence of lacZ gene and/or gene activity, which comprises a stabilizing amount of a solubilizing agent. The present invention also relates to a method for inducing lac operon in screening assay, comprising the step of contacting... Agent: Pierce Biotechnology, Inc.
20130316334 - Transformation of material into an optically modulating state via laser radiation: A method for the transformation of material (e.g. plastic material) into an optically modulating state via laser radiation is described. The optically modulating state may be a state in which light is emitted at a different wavelength than it is absorbed. The plastic material to may be a thermoplastic or... Agent: Alere Technologies Gmbh
20130316336 - Analyzer: Provided is an analyzer capable of reducing the amount of wasted reagents and shortening time required for solution sending, thus increasing throughput for analysis. A microsyringe sucks a minimum required amount of reagent that is substantially the same amount of capacity of a flow cell to a sampling nozzle. Then,... Agent: Hitachi High-technologies Corporation
20130316335 - Sample handling: The invention provides containers and methods of use for the storage, transportation and preparation of samples, such as DNA samples for analysis. The container is pre-provided with the reagents in sealed chambers. The sample can be introduced and the container manipulated to release the reagents, provide the necessary conditions and... Agent: Forensic Science Service Limited
20130316346 - Brassica genomic assays: Methods and compositions for detecting, identifying, and quantifying Brassica A genomic DNA are described. The methods are specific to the Brassica A genome and do not cross-react with other Brassica species, crops or weedy relatives that could contribute to contamination of a canola field.... Agent: E I Du Pont De Nemours And Company
20130316338 - Ccr6 as a biomarker of alzheimer's disease: Disclosed are methods used to diagnose Alzheimer's disease (AD) in a subject. The methods involve determining the amount of chemokine receptor 6 (CCR6) expressed in a biological sample. Expression of CCR6 in the sample that exceeds a threshold level of expression signifies that the subject has AD, even if the... Agent: Oregon Health & Science University
20130316343 - Delta3, fthma-070, tango85, tango77, spoil, neokine, tango129, and integrin alpha subunit protein and nucleic acid molecules and uses thereof: The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins,... Agent: Millenium: The Takeda Oncology Company
20130316339 - Detection of nucleic acid sequences adjacent to repeated sequences: The present invention provides methods of quantifying a target locus adjacent to an extended repeat sequence in genomic DNA. The present invention further provides methods and kits for detecting methylation at a target locus adjacent to an extended repeat sequence in genomic DNA.... Agent: Orion Genomics LLC
20130316342 - Genetic barcodes: Herein are described multicolor FISH probe sets termed “genetic barcodes” targeting several cancer or disease-related loci to assess gene rearrangements and copy number changes in tumor cells. Two, three or more different fluorophores are used to detect the genetic barcode sections thus permitting unique labeling and multilocus analysis in individual... Agent: The Regents Of The University Of California
20130316348 - Herbicide tolerant cotton plants and methods for identifying same: The invention provides specific transgenic cotton plants, plant material and seeds, characterized in that these products harbor a specific transformation event at a specific location in the cotton genome. Tools are also provided which allow rapid and unequivocal identification of the event in biological samples.... Agent: Bayer Bioscience N.v.
20130316344 - Method and probe set for detecting cancer: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer... Agent:
20130316345 - Method of determining the genotype relating to hereditary nasal parakeratosis (hnpk) and nucleic acids usable in said method: The invention concerns an in vitro method of determining a genotype relating to hereditary nasal parakeratosis (HNPK) in a dog. According to the invention the presence or the absence of a genetic variation in the SUV39H2 gene sequence is indicative of said disorder. The invention also concerns polypeptide based methods... Agent: University Of Bern
20130316341 - Methods for detecting gene dysregulations: Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g., translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5′ and 3′ regions of the gene.... Agent: Quest Diagnostics Investments Incorporated
20130316337 - Methods of diagnosing and treating an inflammatory response: The present invention relates to the discovery that VEGF, PlGF, and sFlt-1 levels are increased in inflammatory response such as in sepsis, severe sepsis, or septic shock. Additionally, the invention provides methods of identifying treatments as well as providing treatments for such an inflammatory response, which include decreasing VEGF or... Agent: Beth Israel Deaconess Medical Center
20130316349 - N-methylpurine dna glycosylase and polymerase beta as biomarkers for alkylator chemotherapy potentiation: Described herein is the finding that polymerase β (Polβ) and N-methylpurine DNA glycosylase (MPG) can be used as biomarkers to evaluate the sensitivity of a subject to combination therapy that includes treatment with either temozolomide (TMZ) and methoxyamine, or TMZ and a poly(ADP-ribose) polymerase (PARP) inhibitor. Thus, provided herein is... Agent: University Of Pittsburgh - Of The Commonwealth System Of Higher Education
20130316347 - Process for multi-analyses of rare cells extracted or isolated from biological samples through filtration: A process for isolating or extracting rare cells from a biological sample comprising filtering a biological sample, which may be treated or diluted, through a filter that has a pore size, pore density or other physical properties that retain rare cells, but which permits other kinds of cells to pass... Agent: Rarecells Sas
20130316340 - Systems and methods for multiplexed electrochemical detection: Contemplated methods and devices comprise performing electrochemical sample analysis in a multiplexed electrochemical detector having reduced electrical cross-talk. The electrochemical detector includes electrodes that share a common lead from a plurality of leads. The sample, which may be a liquid sample, is introduced into one or more sample wells and... Agent:
20130316353 - Culture method for obtaining a clonal population of antigen-specific b cells: The present invention relates to methods of isolating antigen-specific cells and producing antibodies therefrom.... Agent: Alder Biopharmaceuticals, Inc.
20130316356 - Detection of nucleic acids and proteins: The invention generally relates to methods for detecting a target nucleic acid and a target protein in a single assay.... Agent: Predictive Biosciences Corporation
20130316354 - Mammalian cytokine; related reagents: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Merck Sharp & Dohme Corp.
20130316359 - Method for determining cancer prognosis: The present invention concerns an in vitro method for determining cancer prognosis for a patient suffering from early-stage or low-grade cancer, said method comprising measuring the expression level of ERRα in a biological sample comprising cancer cells. The invention further pertains to an in vitro method for determining bone metastases... Agent: Universite Claude Bernard Lyon 1
20130316361 - Method for the diagnosis of a carcinoma and uses thereof: The present invention relates to a method for diagnosing a carcinoma or a residual disease associated thereto, or for the prognosis of a carcinoma, or for monitoring the effectiveness of an anti-tumour therapy directed against a carcinoma, or for monitoring the follow-up of an individual affected by a carcinoma, in... Agent: Thd S.p.a.
20130316352 - Methods and compositions for amplification and sequencing of difficult dna templates: This disclosure provides methods and compositions for amplification and sequencing of DNA templates, comprising at least two of: 2′-deoxyinosine-5′ triphosphate, 5-propynyl-2′-deoxycytidine-5′-triphosphate, and 8-oxo-2′-deoxyguanosine-5′-triphosphate. Incorporation of these promoting nucleotides into amplification and sequencing reactions improves the amplification and sequencing of difficult-to-sequence DNA regions such as a GC rich regions or GT... Agent:
20130316351 - Methods and kits for diagnosing conditions related to hypoxia: The present invention provides a method for detecting a condition associated with hypoxia in a subject, a method for determining the severity of a condition associated with hypoxia, a method for determining the effectiveness of a therapeutic treatment of a condition associated with hypoxia and a method for selecting a... Agent:
20130316355 - Methods for isolating a target analyte from a heterogeneous sample: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.... Agent: Nanomr, Inc.
20130316360 - Methods for selecting competent oocytes and competent embryos with high potential for pregnancy outcome: The present invention relates to a method for selecting a competent oocyte or a competent embryo by determining the expression level of specific microRNA species in a body fluid or in cumulus cells.... Agent: Universite De Montpellier 1
20130316358 - Methods of diagnosing disease using overlap extension pcr: e
20130316350 - Nucleic acid molecules containing recombination sites and methods of using the same: The present invention relates to the fields of biotechnology and molecular biology. In particular, the present invention relates to the construction and use of nucleic acid molecules comprising cloning sites which differ in nucleotide sequence. In particular embodiments, the present invention relates to nucleic acid molecules which contain recombination sites... Agent: Life Technologies Corporation
20130316357 - Pdx1-expressing dorsal and ventral foregut endoderm: Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm... Agent: Viacyte, Inc.
20130316362 - Genotoxic testing: The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates DNA damage comprising subjecting a cell (containing a DNA sequence encoding a reporter protein operatively linked to a human GADD45α gene promoter and a human GADD45α gene regulatory element arranged to... Agent: Gentronix Limited
20130316363 - Cell capture system and use thereof: The invention relates to a cell capture system for use in determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using such a cell capture system.... Agent: Charles River Laboratories, Inc.
20130316364 - Selection method and recombinant microorganisms and uses therefor: One or more genes in a biosynthesis pathway for a vitamin or other essential nutrient which is needed for the survival of a microorganism can be used as an effective selective marker to identify cells transformed with an exogenous nucleic acid. The microorganism does not naturally contain or express the... Agent: Lanzatech New Zealand Limited
20130316365 - Method of preparing a biological sample for inspection with electron microscopy and fluorescent light microscopy: The invention relates to a method of forming sections for inspection in an electron microscope and a fluorescent light microscope. Conventionally these sections are made by for example the Tokuyama method, which involves freeze substitution and fixing at cryogenic temperatures. A problem is the time that it takes to come... Agent: Fei Company
20130316367 - Discrete contact mr bio-sensor with magnetic label field alignment: The invention describes a family of sensors for assaying macro-molecules and/or biological cells in solution. The invention also describes methods of making and using the sensors. Each sensor has the form of a well (a hollow cylinder having a floor but no lid) or a trench whose walls comprise a... Agent: Headway Technologies, Inc.
20130316366 - Expression of secreted and cell-surface polypeptides: Some embodiments herein provide compositions and methods for expressing secreted and cell-surface-bound polypeptides in a single cell. In some embodiments, secreted and cell-surface polypeptide are produced from a single polynucleotide. The polynucleotide can comprise a sequence (or sequence encoding a polypeptide) that mediates separation of a membrane anchor from the... Agent: California Institute Of Technology
20130316368 - Multi-target photonic biosensor, and method for manufacturing and preparing same: A component or device is provided for the detection or the measurement in parallel of one or more specific types of biological or chemical target products. This component includes a group of nanotubes selected and/or functionalized to interact with the target product, around an optical waveguide. Thus, an optical coupling... Agent: Centre National De La Recherche Scientifique
20130316373 - Separation of living untouched neurons: The present invention provides the use of the cell surface antigen CD51 as a negative selection marker for neuronal cells and a method for enrichment, isolation and/or detection of neuronal cells comprising the steps a) contacting a sample containing neuronal cells with an antigen-binding fragment specific for the CD51 antigen... Agent: Miltenyi Biotec Gmbh
20130316374 - Breast cancer diagnostics: The present invention relates to methods and means for detecting cancer or of predicting a patient developing cancer or of determining the rate of progression of cancer in a patient suffering from cancer, comprising determining RANKL activity and/or the amount of OPG in a sample of said patient.... Agent: Imba - Institut Fur Molekulare Biotechnologie Gmbh
20130316375 - Diabetes biomarkers: A new markers for insulin production decline in Type 1 diabetes has been found in the ratio the CD4 naïve (CD45RO-CD62L+) to central memory (CD45RO+CD62L+) and in the level of CD4 central memory T-cell subpopulations. A method of diagnosing autoimmunity and its progressiveness, more specifically diabetes, pre-diabetes, a susceptibility to... Agent: Orban Biotech LLC
20130316376 - Spider silk fusion protein structures for binding to an organic target: A protein structure capable of selective interaction with an organic target is provided. The protein structure is a polymer comprising as a repeating structural unit a recombinant fusion protein that is capable of selective interaction with the organic target. The fusion protein is comprising the moieties B, REP and CT,... Agent: Spiber Technologies Ab
20130316369 - Method for detecting escherichia coli: Described herein are methods of detecting an infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification or the substrate, as an... Agent: Systagenix Wound Management (us), Inc.
20130316370 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Beta-nerve growth... Agent: Astute Medical, Inc.
20130316372 - Method of differentiating oncogenic changes of the thyroid, a kit to embody the method and the use of metallothionein (mt) for differentiating oncogenic changes of the thyroid: A method of differentiating oncogenic changes of the thyroid encompassing follicular adenoma and follicular cancer, characterised in that in a sample of oncogenic tissue from a patient the expression of the metallothionein (MT) potein is evaluated using immunochistochemical methods using monoclonal anti-MT antibodies, the degree of intensity of the expression... Agent: Wroclawskie Centrum Badan Eit+sp. Z O.o.
20130316371 - Test kit for plasma or serum antibody titer against periodontal disease-causing bacteria: The object of the present invention is to provide: a test kit for an antibody titer or an antibody against a periodontal disease-causing bacterium in a blood sample, which enables the testing on a periodontal disease in patients having a wide scope of immunotypes with high accuracy and can be... Agent:
20130316381 - Method and reagent device for determining anti-ra33 antibody igg: The present invention provides a method for determining anti-RA33 antibody by ELISA based on a special device. The device comprises a substrate, wherein 8 wells are formed on the substrate, and one end of the substrate is provided with a handle and the handle is adhered with a bar-shaped code... Agent: Shenzhen Yhlo Biotech Co., Ltd.
20130316380 - Methods and assays for measuring p95 and/or p95 complexes in a sample and antibodies specific for p95: The invention provides methods of measuring and/or quantifying the presence and/or amount of p95 and/or p95 complex in a sample. The invention also provides antibodies specific for p95.... Agent: Laboratory Corporation Of America Holdings
20130316377 - Methods for predicting and treating myocardial damage: A method for predicting myocardial damage in a subject having or at risk of cardiac disease includes determining a level of apolipoprotein AI (ApoAI) and a level of Coenzyme Q10 (CoQ10) in the subject and comparing the determined levels of ApoAI and CoQ10 to control levels.... Agent:
20130316378 - Methods of diagnosing acute cardiac disorders using bnp-sp: The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.... Agent: Otago Innovation Limited
20130316379 - Moesin fragments associated with immune thrombocytopenia: The present application provides compositions and methods useful for detecting and monitoring immune thrombocytopenia.... Agent: Shanghai Kexin Biotech Co., Ltd.
20130316382 - Method for evaluating the vital prognosis of a subject in a critical condition: The invention relates to a method for evaluating the vital prognosis of a subject suffering from heart failure, said method comprising the step of determining the lactate/cholesterol ratio in a biological sample of said subject and comparing the lactate/cholesterol ratio to a threshold value.... Agent: Institut National De La Sante Et De La Recherche Medicale (inserm)
20130316383 - Methods of monitoring metabolic pathways: The present invention provides methods and compositions for monitoring cofactors and metabolites of a metabolic pathway of interest. The subject compositions and methods are particularly suited for monitoring the mevalonate pathway in a variety of cells. The invention also provides fermentation methods for the production of isoprenoids.... Agent: Amyris, Inc.
20130316384 - Ice-cleaved alpha-synuclein as a biomarker: The present disclosure provides ICE-cleaved alpha-synuclein fragments as biomarkers for alpha-synuclein-associated disease or disorder and/or for ICE-regulator therapy.... Agent:
20130316385 - Methods and compositions for cell-proliferation-related disorders: Methods and compositions for treating and evaluating subjects having a neoactive mutation at residue 97 of IDH1 or 137 of IDH2.... Agent:
20130316386 - Test element, test kit, test device, and test method: According to one embodiment, a test element includes a base, a pair of optical element units, an optical waveguide unit, a detection unit and a holding unit. The base has transparency. The pair of optical element units are arranged away from each other on a major surface of the base.... Agent: Kabushiki Kaisha Toshiba
20130316387 - Alginate hydrogel fibers and related materials: Alginate hydrogel fibers and related materials as well as methods for preparing such materials are provided. An alginate hydrogel fiber includes water in an amount of more than about 92% by weight of the fiber and a cross-linked alginate in an amount of about 0.1% to about 8% by weight... Agent:
20130316391 - Cells having disrupted expression of proteins involved in adme and toxicology processes: The present invention provides cells comprising disrupted expression of at least one membrane transporter, drug metabolizing enzyme, xenobiotic sensor, or cellular stress response pathway protein. Also provided are methods for assessing the effect of an agent in the cells disclosed herein relative to comparable control cells.... Agent: Sigmaaldrich Co., LLC
20130316389 - Method and system for determining characteristics of an embryo and uses thereof: A method for characterising an embryo is provided, the method comprising determining characteristics of the pattern of movement of the embryo; and comparing the determined characteristics with reference data relating to the expected movement pattern of the subject embryo. The method is of use in the staging of embryos and... Agent: University Of Plymouth
20130316390 - Method for diagnosis and/or prognosis of cancers by analysis of the mechanical properties of tumour cells: A method for diagnosis and/or prognosis of cancers, for diagnosis of the site of origin of tumour cells, for optimizing the treatment of cancer patients and for screening active substances for oncology. In the method, the mechanical properties of tumour cells and reference cells are analyzed under a mechanical load... Agent: Universitat Leipzig
20130316388 - Process and apparatus for rapid, high-throughput analysis of fatty acids: This invention relates to an apparatus and a process for rapid, high-throughput analysis of fatty acids in a plurality of samples. The apparatus comprises at least one multi-vessel plate, wherein each vessel is a unit for holding a sample, or mixing and/or reacting a sample with one or more solvents... Agent: Health Diagnostic Laboratory, Inc.
20130316392 - In vitro tumor in dish kit and method: This invention is a method and kit for preparing a Tumor in Dish model for use in screening anti-cancer agents and analyzing cancer growth and development.... Agent:
20130316393 - Microbial detection article having a water-absorbent filter assembly: A microbial detection article and methods of using the same, the article comprising: a base member comprising a self-supporting water impervious substrate with first and second generally opposed major surfaces; a filter assembly defining a filter assembly aperture therein, and having a composite filter body mounted across the filter assembly... Agent: 3m Innovative Properties Company
20130316395 - Optical particle detecting device and particle detecting method: An optical particle detecting device includes a light source that emits light, an optical fiber that carries the emitted light, an emission-side condensing lens that condenses the light emitted from an end portion of the optical fiber, and a jet mechanism that causes an airstream including a particle to cut... Agent: Azbil Corporation
20130316394 - Viability staining method: The invention relates to a method of detecting viable cells in a cell sample, using a membrane permeable fluorescent label that permeates both viable and non-viable cells and a membrane impermeant quencher that selectively permeates non-viable cells.... Agent: Charles River Laboratories, Inc.
20130316396 - Bioreactor with feed and harvest flow through filter assembly: The present invention relates to a bioreactor and a method for operating a bioreactor which comprises a chamber (100) capable of receiving a liquid media, and a filter assembly (200) comprising a perfusion filter (210; 212; 214). The filter assembly (200) is disposed in the chamber (100) and the filter... Agent: Ge Health Care Bio-sciences Ab
20130316397 - Cell-free polypeptide synthesis: Methods, microbial strains and reaction mixtures for cell-free synthesis of polypeptides are provided. The methods of the invention utilize a reaction mixture comprising microbial cell extracts that are modified in the protein component relative to an extract from a native cell. The modification may be one or both of (i)... Agent:
20130316398 - Efficient production of heterologous proteins using mannosyl transferase inhibitors: Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.... Agent: Merck Sharpe & Dohme Corp.
20130316400 - High yield transient expression in mammalian cells using unique pairing of high density growth and transfection medium and expression enhancers: The present invention is directed generally to cell culture media (particularly serum free, non animal derived, and/or chemically defined media) which are useful for introducing macromolecules and compounds (e.g., nucleic acid molecules) into cells (e.g., eukaryotic cells). According to the invention, such introduction can take place in the presence of... Agent: Life Technologies Corporation
20130316401 - Method for modifying a property of a protein: A method for improving the thermostability of a protein includes introducing, into the protein, two or more amino acid substitutions selected from the group consisting of: (i) substitution of an arginine residue for a lysine residue, (ii) substitution of a threonine residue for a serine residue, and (iii) substitution of... Agent: Ajinomoto Co., Inc.
20130316399 - Promoters for expressing genes in a fungal cell: The present invention relates to isolated promoters and constructs, vectors, and fungal host cells comprising such promoters operably linked to polynucleotides encoding polypeptides. The present invention also relates to methods for producing such polypeptides.... Agent:
20130316402 - Antibodies and immunoconjugates and uses therefor: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.... Agent: Genentech, Inc.
20130316403 - Vectors and yeast strains for protein production: ca2+ atpase overexpression: Lower eukaryote host cells in which an endogenous or heterologous Ca2+ ATPase is overexpressed are described. Also described are lower eukaryote host cells in which a calreticulin and/or ERp57 protein are overexpressed. These host cells are useful for producing recombinant glycoproteins that have reduced O-glycosylation.... Agent: Glycofi, Inc.
20130316404 - Covalently linked interleukin-10: The present invention relates to a polypeptide having interleukin-10 function, comprising two interleukin-10 monomer subunits covalently linked by a linker. The present invention further relates to a nucleic acid molecule encoding the polypeptide of the invention, a vector comprising said nucleic acid molecule, a non-human host transformed with the nucleic... Agent: Technische UniversitÄ T Dresden
20130316405 - Process for the production of a composition containing 5'-ribonucleotides: The present invention describes a process comprising a) subjecting a microorganism to autolysis under conditions at which a substantial part of the RNA remains in a form degradable into 5′-ribonucleotides; b) subjecting the autolysate to solid/liquid separation and recovering the RNA-containing cell wall fraction; and c) converting the RNA in... Agent: DsmIPAssets B.v.
20130316406 - Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic... Agent: Battelle Energy Alliance, LLC
20130316407 - Process of producing a fermentation product: The invention relates to a process of producing a fermentation product in the presence of pyridoxamine.... Agent: Novozymes A/s
20130316408 - Marine streptomyces, pyranosesquiterpene compound, as well as preparation method and applications thereof: The invention discloses marine Streptomyces sp., a Pyranosesquiterpene compound, as well as a preparation method and uses thereof. Streptomyces sp. SCSIO 01689 was collected in China Center for Type Culture Collection (CCTCC) (Address: Wuhan University, Wuhan City, China) with the collection number of CCTCC NO: M 2011257 on Jul. 18,... Agent: South China Sea Institute Of Oceanology, Chinese Academy Of Sciences
20130316409 - Nitrilases, nucleic acids encoding them and methods for making and using them: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.... Agent: Verenium Corporation
20130316410 - Tailored oils: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced... Agent: Solazyme, Inc.
20130316412 - Fermentation and simulated moving bed process: The invention provides an improved method for the production, separation and recovery of one or more fermentation products from a fermentation broth. Further, the invention provides a method for increasing efficiency of a fermentation reaction. In particular, the invention relates to a fermentation system which incorporates a simulated moving bed... Agent: Lanzatech New Zealand Limited
20130316411 - Methods and systems for the production of alcohols and/or acids: Methods and systems for the production of one or more products from a gas stream produced in a methanol production process. The method comprises converting at least a portion of a methane feedstock to a substrate comprising CO and H2. The substrate comprising CO and H2 is anaerobically fermented in... Agent:
20130316413 - Reverse beta oxidation pathway: The invention relates to recombinant microorganisms that have been engineered to produce various chemicals using genes that have been repurposed to create a reverse beta oxidation pathway. Generally speaking, the beta oxidation cycle is expressed and driven in reverse by modifying various regulation points for as many cycles as needed,... Agent: William Marsh Rice University
20130316414 - Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria: A high flux of metabolites from pyruvate to 2,3-butanediol in Lactobacillus plantarum was achieved through genetic engineering. Substantial elimination of lactate dehydrogenase activity in the presence of heterologously expressed butanediol dehydrogenase activity led to 2,3 butanediol production that was at least 49% of the total of major pyruvate-derived products.... Agent: Butamax Advanced Biofuels LLC
20130316415 - Production of branched-chain alcohols by photosynthetic microorganisms: The present invention provides genes, polypeptides and expression constructs therefor, recombinant photosynthetic microorganisms, and method of use thereof, such as for the production of branched-chain alcohols (including 2-methyl-1-butanol, 3-methyl-1-butanol, and isobutanol) and derivatives thereof for a variety of uses.... Agent: Synthetic Genomics, Inc.
20130316416 - Engineering microbes and metabolic pathways for the production of ethylene glycol: The invention relates to recombinant cells and their use in the production of ethylene glycol.... Agent: Massachusetts Institute Of Technology
20130316418 - Method for producing 2,3-butanediol by fermentation: The invention relates to a production strain for producing 2,3-butanediol. Said production strain can be produced from an original strain selected from the genes Klebsiella, Raoultella, Paenibacillus and Bacillus and has an acetoin reductase activity at least 3.6-34.8 times higher than the original strain. The invention also relates to the... Agent: Wacker Chemie Ag
20130316419 - Method for producing 2,3-butanediol by fermentation: The invention relates to a microorganism strain which has an acetolactate decarboxylase activity 2-12.8 times higher than the non-improved original strain. The invention also relates to a method for producing 2,3-butanediol (2,3-BDL) by fermentation by means of said strain.... Agent: Wacker Chemie Ag
20130316417 - Process for the conversion of glycerol to 1,3-propanediol: The present application includes a process and a microorganism of the genus Lactobacillus that converts glycerol to 1,3-propanediol. The conversion is accomplished by a proprietary microorganism that is easily cultured in glycerol rich waste products of ethanol production, such as thin stillage.... Agent: University Of Saskatchewan
20130316424 - Carbon capture in fermentation: The invention relates to methods of capturing carbon by microbial fermentation of a gaseous substrate comprising CO. The methods of the invention include converting CO to one or more products including alcohols and/or acids and optionally capturing CO2 to improve overall carbon capture. In certain aspects, the invention relates to... Agent: Lanzatech New Zealand Limited
20130316422 - Method of operation of a syngas fermentation process: A process is provided for fermentation of syngas that is effective for reducing conductivity and providing an alcohol STY of about 10 g ethanol/(L·day). The process includes introducing the syngas into a reactor vessel and providing a nitrogen feed rate to the reactor vessel of about 100 mg or more... Agent: Ineos Bio S.a.
20130316423 - Process for fermenting co-containing gaseous substrates: A process is provided for fermenting CO-containing gaseous substrates. Bacteria are sporulated and then germinated in the presence of a CO-containing gaseous substrate to provide an inoculum. The resulting inoculum is effective for providing a fermentation with an ethanol productivity having a specific STY of 1 or greater.... Agent:
20130316420 - Syngas fermentation process and medium: A process for fermenting syngas and a fermentation medium provides high ethanol productivity while removing medium components that were previously thought to be essential. The process is effective for providing a specific STY of at least about 1 g ethanol/(L·day·gram cells). In this aspect, the fermentation medium has less than... Agent:
20130316421 - Syngas fermentation process and medium: A process for fermenting syngas and a fermentation medium provides high ethanol productivity while removing medium components that were previously thought to be essential. The process is effective for providing a specific STY of at least about 1 g ethanol/(L·day·gram cells). In this aspect, the fermentation medium has a weight... Agent: Ineos Bio S.a.
20130316426 - Methods for synthesis of olefins and derivatives: The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method... Agent: Genomatica, Inc.
20130316425 - Production of alkenes by combined enzymatic conversion of 3-hydroxyalkanoic acids: The present invention relates to a method for generating alkenes through a biological process. More specifically, the invention relates to a method for producing alkenes (for example propylene, ethylene, 1-butylene, isobutylene or isoamylene) from molecules of the 3-hydroxyalkanoate type.... Agent: Global Bioenergenies
20130316427 - Foam microreactor for multi-phase shear-sensitive reactions: The present invention relates to a method for controlling multi-phase chemical reactions using the architecture of surfactant foams to control mass transport of chemical reactants, catalysts, and products and the kinetics with which they react. More specifically, the invention relates to transformations that require both gaseous and liquid components with... Agent:
20130316428 - Process for the production of fuel gas from municipal solid waste: After separating from solid urban waste an organic fraction containing biological cells, the latter is extruded through a grid having small-bore holes, under a pressure higher than the bursting pressure of the cell membranes, so that most of these are disrupted and a gel of a doughy consistency is produced.... Agent: Vm Press S.r.l.
20130316429 - Anti-apoptosis or anti-necrosis induction method: Disclosed herein is a method for simply inducing an anti-apoptotic effect and/or an anti-necrotic effect in a living cell with good control without administering any drug. The method includes applying an alternating-current voltage to the living cell so that an electric current of 25 μA or higher but 75 μA... Agent: Fukuoka University
20130316430 - Polyvinyl chloride surface co-immobilized with enzymes and uses thereof: A PVC surface co-immobilized with the multiple enzymes for removal of stains useful in the field of washing or cleaning cloth and other household textile such as towels and sheets. The present invention also provides a process of preparation of the PVC surfaces and using such PVC surface. The PVC... Agent: Maharshi Dayanand University
20130316431 - Immobilized organophosphate-degrading enzymes and methods of making the same: The present application discloses immobilized enzymes and immobilized enzyme materials comprising a crosslinked organophosphate-degrading enzyme having a support material which includes a biomass material and/or a polymeric material. The resulting immobilized enzyme materials may be biodegradable. The present application also discloses methods of making and using the disclosed immobilized organophosphate... Agent:
20130316432 - Inhibitors of extracellular proteases: Provided is a plant derived extract including inhibitory activity against one or more extracellular proteases which degrade human tissue matrix. Moreover, the amount of inhibitory activity in an extract can be increased by stressing the plant prior to forming an extract. These extracts are each prepared by a process and... Agent:
20130316433 - Enzyme composition and methods to transform perfluoroalkyl compounds in soil and/or groundwater: The present disclosure provides systems and methods for at least partially remediating soil and/or groundwater containing perfluroroalkyl compounds (PFCs). In some embodiments, the systems and methods utilize an oxidase such as laccase, optionally with one or more enzyme-catalyzed oxidative humification reaction (ECOHR) mediators. In some embodiments the method is an... Agent:
20130316434 - Animal protein free media for cultivation of cells: The present invention relates to animal protein free cell culture media comprising a combination of non-animal derived peptides derived from soy hydrolysate and yeast hydrolysate. The invention also provides an animal protein free culture process, wherein cells are cultivated, propagated and passaged without animal-derived components. This process is useful for... Agent: Baxter International Inc.
20130316435 - Process for culturing microorganisms on a selected substrate: A process is provided that is effective for allowing bacteria to be cultured in a selected substrate. Bacteria are sporulated and then germinated in the presence of a selected substrate and medium.... Agent:
20130316437 - Methods and compositions for improving sugar transport, mixed sugar fermentation, and production of biofuels: The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods... Agent: The Board Of Trustees Of The University Of Illinois
20130316436 - Novel sphingomonas sp. microorganism, and method for decomposing methane or odor-producing compounds using same: The present invention relates to a Sphingomonas sp. MD2 strain (KCTC 11845BP), a composition including the strain for decomposing methane or odor-producing compounds, a biocover or biofilter including the composition, a method for decomposing methane or odor-producing compounds using the composition, a system for decomposing methane or odor-producing compounds using... Agent:
20130316438 - Methods for increasing homologous recombination of a nucleic acid sequence: The present invention relates to methods for increasing homologous recombination of a nucleic acid sequence introduced into a host cell, comprising: (a) introducing into a population of filamentous fungal host cells a first nucleic acid sequence encoding a recombination protein and a second nucleic acid sequence comprising one or more... Agent:
20130316439 - Biomass production: A process of growing a phototrophic biomass in a reaction zone, including a reaction mixture that is operative for effecting photosynthesis upon exposure to photosynthetically active light radiation, is provided. The reaction mixture includes phototrophic biomass that is operative for growth within the reaction zone. In one aspect, the carbon... Agent: Pond Biofuels Inc.
20130316440 - Device for inspecting a biological fluid: A device for inspecting a biological fluid, including a channel through which the fluid flows, a first inspection module arranged in a first region of the channel, and a second inspection module arranged in a second region of the channel, the device configured to provide a quantity that is representative... Agent: Universite De Limoges
20130316441 - Genetic analyzer: A nucleic acid analysis apparatus capable of selecting an optimal analysis method for every user and improving throughput is provided. In a genetic analyzer for measuring and analyzing amplification reaction of a nucleic acid in real time, an amplification curve is analyzed and a user can select conditions for terminating... Agent: Hitachi High-technologies Corporation
20130316442 - Monitoring system for cell culture: Cell culture environment monitoring system (6) for monitoring parameters relevant to cell growth in at least one culture dish (4) containing a cell growth medium (14), including at least one sensing device (22, 22′) configured to measure environmental parameters relevant to cell growth, and a tray (24) supporting said at... Agent: Ecole Polytechnique Federale De Lausanne (epfl)
20130316444 - Apparatus for analyzing particles in urine and method thereof: An apparatus, intended for use in analyzing particles in urine is disclosed, that comprising: a sample distribution section for distributing urine samples to a first aliquot and a second aliquot; a first specimen preparing section for preparing a first specimen for measuring urinary particles, containing at least erythrocytes, by mixing... Agent: Sysmex Corporation
20130316443 - System for detecting microorganisms: A system for detecting microorganisms in a test sample is provided that includes a fluorescently detectable product having both acidic and basic species, wherein the fluorescently detectable product is the reaction product of (a) an enzyme substrate that comprises an enzymatically hydrolysable group and a fluorescent group and (b) a... Agent: 3m Innovative Properties Company
20130316445 - Automated method and apparatus for embryonic stem cell culture: The invention concerns methods for automated culture of embryonic stem cells (ESCs) such as human ESCs. In some aspects, methods of the invention employ optimized culture media and limited proteolytic treatment of cells to separate cell clusters for expansion. Automated systems for passage and expansion of ESCs are also provided.... Agent: Cellular Dynamics International, Inc.
20130316446 - Bioreactor including a rocking device: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the... Agent: Ge Health Care Bio-sciences Ab
20130316447 - Oncolytic virus: Malignant tumors that are intrinsically resistant to conventional therapies are significant therapeutic challenges. An embodiment of the present invention provides an oncolytic virus capable of killing target cells, such as a tumor cells. In various embodiments presented herein, the oncolytic virus is armed or encodes a therapeutic polypeptide. In at... Agent: The Ohio State University Research Foundation
20130316448 - Peptides and related molecules that modulate nerve growth factor activity: The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically active polypeptides comprising peptides linked to one or more Fc domains are... Agent: Amgen Inc.
20130316449 - Supercoiled minicircle dna for gene therapy applications: The present invention relates to nucleic acid molecule compositions comprising minivectors encoding a nucleic acid sequence and methods of gene therapy using minivectors encoding a nucleic acid sequence.... Agent: Baylor College Of Medicine
20130316450 - Compositions and methods for diagnosing and treating cancer: Isolated antibodies that specifically bind the human MET Receptor and inhibit MET signaling are described. Also described are methods of treating cancer, the methods comprising administering a therapeutically effective amount of the provided MET antibodies and combinations thereof.... Agent: Oncomed Pahrmaceuticals, Inc.
20130316451 - Modalities for the treatment of degenerative diseases of the retina: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.... Agent: Advanced Cell Technology, Inc.
20130316452 - Modalities for the treatment of degenerative diseases of the retina: This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.... Agent: Advanced Cell Technology, Inc.
20130316453 - Composition for enhancing cellular uptake of carrier particles and method for the same: A composition for enhancing cellular uptake of carrier particles comprises a delivery system for a drug or biochemical molecule; and a polyphenolic compound, wherein the polyphenolic compound is added to the drug or biochemical molecule delivery system to enhance cellular uptake of drug or biochemical molecules carried by the delivery... Agent: Chang Gung University
20130316454 - Methods for producing tissue scaffold directing differentiation of seeded cells and tissue scaffolds produced thereby: Methods for producing a tissue scaffold which direct differentiation of seeded stem cells on the scaffold to a selected cell type and tissue scaffolds produced thereby are provided.... Agent: The Trustees Of Columbia University In The City Of New York
20130316455 - Method of isolating cells from a tissue in a mammal: Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are also disclosed. The solutions and suspensions may be employed in methods of... Agent: Opk Biotech, LLC.
20130316456 - Cell transdifferentiation into brown adipocytes: A method for converting animal cells into brown adipose tissue cells is provided that includes transforming the animal cells using an expression vector. The expression vector includes a nucleotide sequence encoding HB-EGF operatively linked to a promoter and a nucleotide sequence encoding ADAM 12 operatively linked to a promoter. Converting... Agent: Miami University
20130316457 - Compositions and methods for altering tocotrienol content: The invention provides isolated nucleic acids and their encoded polypeptides that alter tocol content in seeds. The invention further provides expression cassettes, host cells and transformed plants containing the nucleic acids. The present invention further provides methods for altering tocol content in seeds.... Agent: E.i. Dupont De Nemours And Company
20130316458 - Photosynthetic microorganisms expressing thermostable lipase: The present invention encompasses a photosynthetic microorganism that produces biofuels and biofuel precursors.... Agent: The Arizona Board Of Regents For And On Behalf Of Arizona State University11/21/2013 > 122 patent applications in 70 patent subcategories.
20130309651 - Compositions and methods for improving the quality of processed sperm: The present invention relates to compositions and methods for the handling of processed sperm including samples that are freshly collected, those transported as fresh samples, samples that are frozen and thawed, those sorted into one or more subpopulations, and those that are otherwise processed or handled that impose trauma on... Agent: Inguran, LLC
20130309653 - Sperm cell separation system: A sperm cell process system providing to generate sperm cell insemination samples having controlled sperm cell fertility characteristics of sperm cells.... Agent: Xy,llc
20130309652 - System and method for automated platelet wash: A method for washing platelets includes introducing anticoagulant into a platelet product container, drawing re-anticoagulated platelet product from the platelet product container, and introducing it into a centrifuge bowl. The centrifuge bowl separates the platelets from the supernatant in which they are suspended. The method then washes the platelets by... Agent:
20130309654 - Method of selecting a surface chemistry for culturing a given cell line: In one embodiment of the invention, there is provided a method of selecting a surface chemistry for culturing a given cell line, including the steps of: (i) providing a first substrate having a plasma polymerized surface with first and second regions, said first region having a first concentration of carboxylic... Agent: Corning Incorporated
20130309655 - Capillary electrophoresis method for fine structural analysis of enoxaparin sodium: A capillary electrophoresis method for quantitatively analyzing characteristic oligosaccharide present in enoxaparin sodium is provided in this invention. The method may be used for quantitatively determining the contents of disaccharides, trisaccharides, tetrasaccharides and in particular oligosaccharides having a 1,6-anhydro ring, which are unique compounds for enoxaparin sodium, within an exhaustively... Agent: Hangzhou Jiuyuan Gene Engineering Co., Ltd.
20130309656 - Antibody detection method and device for a saliva sample from a non-human animal: A rapid test apparatus, system, and method of use utilizing lateral flow immunoassay (LFIA) detection of a selected ligand in a liquid sample from a body fluid such as saliva in a pet in which antibodies and their complimentary antigens are used with detection-nanoparticles to provide a visual or measurable... Agent:
20130309657 - Devices and methods for separating particles: Embodiments of the present disclosure provide for particle-imprinted polymer films, methods of making particle-imprinted polymer films, methods for separating particles, devices or systems for separating particles, and the like.... Agent: The Board Of Trustees Of The Leland Stanford Junior University
20130309658 - Method for detecting human papillomavirus mrna: An in vitro method is provided for screening human female subjects to assess their risk of developing cervical carcinoma which comprises screening the subject for expression of mRNA transcripts from the E6 and optionally the L1 gene of human papillomavirus, wherein subjects positive for expression of L1 and/or E6 mRNA... Agent: Norchip A/s
20130309659 - Cell culturing formulation and culturing and quantification method of cd140b+ cells thereof: The present invention discloses a cell culturing formulation and a culturing and quantification method of CD140b+ cells thereof. The cell culturing formulation is applicable for inducing the growth of the CD140b+ cells in peripheral blood. The cell culturing formulation comprises a culturing medium, a serum, a mixed additive and a... Agent: Chang-gung University
20130309661 - Free solution measurement of molecular interactions by backscattering interferometry: Disclosed are methods, systems, and apparatuses for the free solution measurement of molecular interactions by backscattering interferometry. In one aspect, the invention relates to method and systems for detecting molecular interaction between analytes in free-solution wherein the analytes are label-free and detection is performed by back-scattering interferometry. Also disclosed are... Agent: Vanderbilt University
20130309662 - Method of separating target cell in biological sample: Provided is a method of separating a rare cell from a sample comprising incubating a sample comprising a rare cell and a second cell with a particle comprising a moiety capable of binding to the rare cell to form a complex comprising the particle and the rare cell; applying the... Agent: Samsung Electronics Co., Ltd.
20130309660 - Methods of characterizing, determining similarity, predicting correlation between and representing sequences and systems and indicators therefor: A computer implemented method for characterizing one or more sequences by generating index values representing portions of the sequences and finding characterizing index values based on a comparison of the index values. The index values may be obtained by applying one or more mask over each sequence. The modified masks... Agent: Real Time Genomics, Inc.
20130309674 - Analysis of the methylation pattern of the alpha-synuclein gene from dna of peripheral blood monocytes for diagnosing parkinson's disease: A method of using peripheral blood monocytes of a patient to at least one of diagnose and assess a risk of a patient of developing Parkinson's disease includes obtaining peripheral blood monocytes from the patient, and determining a methylation pattern of the SNCA(−926/−483) region of the SNCA gene of the... Agent: Rheinische Friedrich-wilhelms Universitaet Bonn
20130309664 - Heat shock proteins as autoantigens: The present invention relates to methods of diagnosing and/or determining a prognosis for various diseases, including lung diseases such as idiopathic pulmonary fibrosis, chronic obstructive lung disease, and emphysema as well as osteoporosis, comprising detecting the presence of autoantibodies specific for heat shock proteins in a subject.... Agent: University Of Pittsburgh- Of The Commonwealth System Of Higher Education
20130309663 - Method for detecting mutations at il28b and itpa: The disclosure relates to probes for detecting a polymorphism in the IL28B gene and in the ITPA gene, and methods of use thereof.... Agent: Arkray, Inc.
20130309668 - Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation: The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the preparation, amplification and analysis of Methylome libraries. In particular, the method employs preparation of a DNA molecule by digesting the DNA molecule with at least one methylation-sensitive restriction enzyme;... Agent: Rubicon Genomics, Inc.
20130309673 - Methods and compositions for nucleic acid amplification: Compositions, reaction mixtures, and methods for performing an amplification reaction, including multiplex amplification reaction, wherein the method comprises using one or more amplification oligomer complexes comprising linked first and second amplification oligomer members. In one aspect, the amplification oligomer complex is hybridized to a target nucleic acid, the target nucleic... Agent: Gen-probe Incorporated
20130309666 - Methods and processes for non-invasive assessment of genetic variations: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.... Agent: Sequenom, Inc.
20130309669 - Methods of identification using methylation of cpg: The invention comprises a method of detecting cancer in a patient by detecting methylated DNA at a specific locus by treating the patient's sample with a methyl-active cleavage method utilizing 5-methyl deoxycytidine glycosylase/lyase.... Agent: Roche Molecular Systems, Inc.
20130309675 - Microparticle having single-molecule nucleic acid probe, method for producing same, method for analyzing nucleic acid using same, device for nucleic acid analysis, and apparatus for analyzing nucleic acid: A microparticle having a probe molecule able to capture a specific nucleic acid group to be analyzed is used to extract only the specific nucleic acid group to be analyzed from a nucleic acid sample and the microparticle is thereafter directly immobilized on a smooth plate, whereby a device for... Agent: Hitachi High-technologies Corporation
20130309670 - Nuclease-mediated targeting with large targeting vectors: Compositions and methods are provided for making one or more targeted genetic modifications at a target genomic locus by employing homologous recombination facilitated by single or double-strand break at or near the target genomic locus. Compositions and methods for promoting efficiency of homologous recombination between an LTVEC and a target... Agent: Regeneron Pharmaceuticals, Inc.
20130309665 - Polymorphisms in the human gene for the multidrug resistance-associated protein 1 (mrp-1) and their use in diagnostic and therapeutic applications: The present invention relates to a polymorphic MRP-1 polynucleotide, genes or vectors comprising the polynucleotides and a host cell genetically engineered with the polynucleotide or gene. Also provided are methods for producing molecular variant polypeptides, cells capable of expressing a molecular variant polypeptide and a polypeptide encoded by the polynucleotide... Agent:
20130309667 - Primers for analyzing methylated sequences and methods of use thereof: Primers having abasic regions or mismatches for amplifying sequences suspected of having methylation. Primers having abasic regions or mismatches for amplifying sequences adjacent to suspected or known methylated sequences. Methods of using primers having abasic regions or mismatches for identification of methylated sequences or sequences adjacent to suspected or known... Agent:
20130309672 - Soybean transgenic event mon87705 and methods for detection thereof: The present invention provides a transgenic soybean event MON87705, and cells, seeds, and plants comprising DNA diagnostic for the soybean event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for said soybean event in a sample, methods for detecting the presence of said soybean event nucleotide sequences... Agent: Monsanto Technology LLC
20130309671 - Spectro-temporal optical encoding of information using a time-gated fluorescence resonance energy transfer (fret): Described herein is a time-gated, two-step FRET relay effective to provide temporal transference of a prompt FRET pathway, or provide spectro-temporal encoding analytical signals and other information. A FRET relay assembly includes a long lifetime FRET donor (for example, a lanthanide complex), a semiconductor quantum dot (QD) configured as an... Agent: The Government Of The United States Of America, As Represented By The Secretary Of The Navy
20130309676 - Biased n-mers identification methods, probes and systems for target amplification and detection: A method for selecting oligonucleotides for biased polynucleotide amplification is described. Related probes, methods and systems are also described.... Agent: Alfred E. Mann Foundation For Scientific Research
20130309678 - Compositions and methods for nucleic acid sequencing: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are... Agent: Pacific Biosciences Of California, Inc.
20130309679 - Fluidic devices and systems for sample preparation or autonomous analysis: The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis.... Agent: Slipchip, LLC
20130309681 - Immortalization of epithelial cells and methods of use: The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte epithelial cells in the presence of feeder cells and a calcium-containing medium while inhibiting the activity of Rho kinase (ROCK) in the feeder cell, the non-keratinocyte epithelial cells or both during culturing.... Agent: Georgetown University
20130309677 - In vitro model for pathological or physiologic conditions: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also... Agent: Hemoshear, LLC
20130309680 - Method of determining rna integrity: A method of determining a quantitative measure of the integrity of RNA in a sample, the method comprising: (i) assaying a sample containing instances of an RNA molecule transcribed from a reference gene, at least some of the instances being damaged, to determine quantitative measures of the relative or absolute... Agent:
20130309683 - Methods and compositions for detecting and identifying species of candida: Methods and compositions useful in the detection and identifcation of species of Candida are disclosed. The compositions are combinations of oligonucleotides, where the forward primers of the primer pairs have identical sequences, while each reverse primer of the primer pairs has a unique sequence relative to all of the other... Agent: Medical Diagnostic Laboratories, LLC
20130309684 - Nucleic acid-free thermostable enzymes and methods of production thereof: The present invention provides thermostable enzymes, such as DNA polymerases and restriction endonucleases, that are substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in amplifying or sequencing nucleic acid molecules, including... Agent: Life Technologies Corporation
20130309682 - Ribosomal polynucleotides and related expression systems: Provided herein is a synthetic or isolated polynucleotide encoding a mammalian 18S rRNA that is resistant to pactamycin. The pactamycin-resistance is conferred by one or more single residue substitutions in the 18S rRNA sequence; a fragment thereof harboring said substitutions; a complementary sequence thereto; or a substantially identical sequence of... Agent:
20130309685 - Method for target based cancer classification, treatment, and drug development: A method of classifying a cancerous tumor is described and comprises the steps of: screening a set of targetable events within a tumor, determining a profile for tumor, and classifying the tumor based on the variant profile of the tumor. More specifically, the tumor is defined and classified based on... Agent:
20130309686 - Viability staining method: The invention relates to a method of detecting viable cells in a cell sample, using a membrane permeable fluorescent label that permeates both viable and non-viable cells and a membrane impermeant quencher that selectively permeates non-viable cells.... Agent: Charles River Laboratories, Inc.
20130309687 - Biomarker and therapeutic for urinary tract infection: The present invention encompasses methods and compositions for detecting pathogenic bacteria. Additionally, the present invention encompasses methods and compositions for catalyzing the dismutation of superoxide radicals.... Agent: The Washington University
20130309688 - Efficient processing systems and methods for biological samples: Systems and methods of sample and staining processing including compression and dynamic movement of liquids in a fluidically moving substantially contained liquid bridge perhaps between a hydrophobic wand and a hydrophilic sample support element. Embodiments may include low volume reagent and perhaps even low volume buffer wash in sample processing.... Agent:
20130309689 - Methods and reagents for biomolecule labeling, enrichment and gentle elution: Methods and sets of non-biological reagents (elution reagents, tag isomers, tag reactive groups, crosslinkers) for single or multiplexed capture and gentle elution of biomolecules. Examples are provided using amine- and cysteine-reactive reagents for enrichment of proteins, peptides, and rare peptide modifications.... Agent: Pierce Biotechnology, Inc.
20130309690 - Tetrameric alpha-synuclein as biomarkers: The present invention provides the surprising finding that alpha-synuclein exists in vivo as a folded tetramer. Provided are various methods and technologies that arise from this finding, including methods and kits for identifying individuals susceptible to or suffering from certain diseases, disorders or conditions associated with stability of alpha-synuclein tetramers,... Agent: Brandeis University
20130309692 - Markers for detecting human follicular helper t cells and method for detecting human follicular helper t cells: The present invention relates to polynucleotide markers and protein markers for detecting human follicular helper T cells. The present invention also relates to methods for detecting human follicular helper T cells using the markers.... Agent: Sysmex Corporation
20130309693 - Polypeptides for microbial detection: Polypeptides which can be activated to cause the formation of pores in a lipid membrane are disclosed. Also disclosed are polypeptide compositions for the detection of target microorganisms and methods of using said compositions.... Agent: 3m Innovative Properties Company
20130309691 - Use of heat-resistant biotin-binding protein, and solid support having the protein attached thereto: The present invention relates to a solid support having a heat-resistant biotin-binding protein attached thereto. The present invention also relates to the use of the solid support of the present invention having a heat-resistant biotin-binding protein attached thereto. The present invention further relates to technical fields such as purification, concentration,... Agent: Japan Tobacco Inc.
20130309697 - Biomarkers for prostate cancer and methods using the same: Methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for prostate cancer.... Agent:
20130309694 - Hybridoma cell line for producing antibody for type ii collagen: The present invention provides a hybridoma cell line (DSM ACC3145), wherein the hybridoma cell line produces an antibody which specifically binds to an amino acid sequence of type II collagen comprising: K-G-E-P-G-D-D-G-P-S-C (as set forth in SEQ ID NO. 1); and a method for detecting osteoarthritis, by identifying a presence... Agent:
20130309698 - Methods for diagnosing systemic lupus erythematosus: The present invention provides methods of diagnosing and monitoring systemic lupus erythematosus.... Agent: Exagen Diagnostics, Inc.
20130309695 - Methods of diagnosing asthma: A method of detecting a risk for or presence of asthma in a subject. The method comprises obtaining a biological sample comprising human airway smooth muscle cells from a subject and testing the biological sample for the presence of a pentraxin-3 (PTX3) polypeptide. The presence and/or quantity of PTX3 polypeptide... Agent: University Of Manitoba
20130309696 - Therapeutic and diagnostic methods for alzheimer's disease: The invention relates to diagnosing the presence or absence of antibodies, such as IgM, IgG or IgA antibodies, related to increased or decreased risk of developing Alzheimer's disease, using a phosphorylcholine conjugate. In addition, the invention relates to methods of immunization and prophylaxis, prevention and/or treatment of a subject against... Agent: Athera Biotechnologies Ab
20130309699 - Antibody purification via affinity chromatography: Embodiments herein provide methods of purifying monoclonal and polyclonal anti-bodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins,... Agent: University Of Notre Dame Du Lac
20130309700 - Methods, devices, and systems of detecting microorganisms: A rapid, sensitive method of separating and detecting microorganisms from a sample containing microorganisms, such as but not limited to bacteria, fungi, yeast, viruses, and the like. The method relies on separation techniques to separate and concentrate the cells from the sample, together with chemical techniques to amplify the amount... Agent: Celsis International Limited
20130309701 - Nucleic acid fragment encoding a horseshoe crab-derived pro-clotting enzyme: Objects of the present invention are to provide a DNA fragment encoding a limulus-derived pro-clotting enzyme, a virus harboring the DNA fragment, a cell harboring the virus, a method of producing the pro-clotting enzyme by use of the cell, and means for assaying an endotoxin or (1→3)-β-D-glucan employing the enzyme,... Agent: Seikagaku Corporation
20130309702 - Magnetic nanoparticle, having a curie temperature which is whithin biocompatible temperature range, and method for preparing same: The present invention relates to a magnetic nanoparticle having a Curie temperature which is within a biocompatible temperature range, a method for preparing same, and a nanocomposite and a target substance detection composition comprising the magnetic nanoparticle. As the magnetic nanoparticle of the present invention has a Curie temperature within... Agent: Korea University Research And Business Foundation
20130309703 - Novel method for analyzing glycosaminoglycan: A method of analyzing a sugar chain by high performance liquid chromatography uses a column packed with a stationary phase including anion and cation exchangers. A fluorescence-labeled sample is prepared for the analysis by decomposing glycosaminoglycans to be analyzed into their constitutional units being disaccharides, capturing the disaccharides by glycoblotting,... Agent: Cellseed, Inc.
20130309704 - Method and apparatus for measuring physiologically active substance derived from organism: The purpose of the present invention is to improve the measurement accuracy in the measurement of the concentration of a physiologically active biological substance in a sample by a stirring turbidimetry, a light scattering method or an AL-bound beads method, wherein the purpose can be achieved by preventing the occurrence... Agent: Kowa Company, Ltd.
20130309705 - Method for determining the concentration of hmg-coa reductase inhibitors: The invention, which belongs to the field of enzymology and pharmaceutical chemistry, relates to a method for determining the concentration of a HMG-CoA reductase inhibitor, and to a method for determining the inhibition rate of HMG-CoA reductase. In particular, the method for determining the inhibition rate of HMG-CoA reductase comprises... Agent: Beijing Peking University Wbl Biotech Co. Ltd
20130309707 - Circulating tumor cell capturing techniques and devices: Candidate cells, such as circulating tumor cells (CTCs), present with blood are captured using a multiple stage device, having successive stages configured to deviate candidate cells out of the blood while slowing down the flow rates of the deviated resultant for easier capture of CTCs through progressive stages. The devices... Agent:
20130309708 - Compositions and methods useful for culturing differentiable cells: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.... Agent: Viacyte, Inc.
20130309710 - Observation system, recording medium, and control method of observation system: An observation system to observe a sample mass formed of samples gathering in a container containing the samples and a solution, includes: an entire image pickup unit to image the entire container; a sample mass identification unit to identify a sample mass formed in the container, from a macro observation... Agent: Sanyo Electric Co., Ltd.
20130309709 - Photouncaging-assisted evaluation of large-scale synaptic reorganization of brain circuits: Photouncaging-assisted evaluation of large-scale synaptic reorganization of brain circuits and methods in use thereof. The current invention utilizes laser-scanning photostimulation in large-scale and with higher accuracy to detect synaptic reorganization in neurological disorders, such as Alzheimer's disease, Parkinson's disease and epilepsy. Using the invention's methodology, disease and non-disease conditions can... Agent: The Florida State University Research Foundation, Inc.
20130309706 - Selective 3d biopatterning: Methods, systems, and articles for selective three dimensional (3D) biopatterning are disclosed. A biological target may be imaged and a selected area of the image may define a desired pattern for guiding the emission of EM radiation into the biological target. Two or more groups of photosensitive elements responsive to... Agent: Empire Technology Development LLC
20130309711 - Preparing blood smears on a fiber surface: The present application discloses methods and apparatus for preparing blood film or smear samples on a fiber surface, staining the test sample, and generating digital cell images of the films or samples for classification and review. The techniques disclosed herein replace conventional microscope slides with fibers when preparing blood film... Agent:
20130309712 - Mass spectrometric identification of hyphal fungi: A method is provided for identifying a hyphal fungus in a sample by similarity comparisons between a mass spectrum of the fungus and reference spectra. The method includes growing fresh hyphae without any adhering contact to surfaces as to form a mycelium with undifferentiated hyphae cells. A sample is prepared... Agent:
20130309714 - Methods for inactiviation and extraction of acid-fast bacteria for characterization and/or identification using mass spectrometry: The present invention is directed to a method for inactivation and/or extraction of acid-fast bacteria (e.g., mycobacteria or nocardia), the method comprising the following sequential steps: (a) acquiring a test sample known to contain or that may contain acid-fast bacteria and suspending the test sample in a container containing ethanol... Agent: Biomerieux, Inc.
20130309713 - Pathogen detection systems and methods: Pathogen and chemical detection systems for use with a patient support apparatus and related methods are disclosed. A fluid or biologic sample from the vicinity of a person supported by a person support apparatus is acquired and transmitted to a pathogen detection sensor. A graphical caregiver interface is supplied output... Agent:
20130309715 - Pentamethine cyanine fluorescent dyes, preparation methods and uses thereof: A pentamethine cyanine fluorescent dye having the general formula I, a synthetic method and a use thereof are disclosed. In the general formula, X is CHO or CHCR3R4; R1 and R2 are independently selected from the group consisting of (CH2)nR2 and et al.; R3 and R4 are independently selected from... Agent:
20130309716 - Methods for inactiviation and/or extraction of a fungus test sample for characterization and/or identification using mass spectrometry: The present invention is directed to a method for inactivation and/or extraction of fungus samples (e.g., mold or yeast samples), the method comprising the following sequential steps: (a) acquiring a test sample known to contain or that may contain fungus and suspending the test sample in a container containing water... Agent: Biomerieux Inc.
20130309717 - Method of cutting at least one thin section and tagging at least one specimen slide: A method of cutting at least one thin section from a sample block that is arranged in a cassette and tagging at least one specimen slide such that it can be allocated to the specific sample block from which the thin section has been cut. The method includes removing a... Agent:
20130309718 - Methods and compositions for a microemulsion-based tissue treatment: The invention is directed to methods and compositions for deparaffinizing paraffin-embedded biological samples for subsequent tissue staining. The compositions are microemulsions that may include water/oil/surfactant microemulsions, and optionally a cosurfactant. The microemulsions enable deparaffinization without the use of xylene or toluene, and also enable solvent exchange without the use of... Agent: Ventana Medical Systems, Inc.
20130309719 - Heterotrophic microbial production of xanthophyll pigments: The invention relates to a microbial biomass wherein the biomass comprises at least one xanthophyll selected from any one or more of fucoxanthin, diatoxanthin and diadinoxanthin. The invention further relates to a process for producing such a microbial biomass. Further the invention relates to compositions comprising at least one xanthophyll... Agent: Photonz Corporation Limited
20130309720 - Methods and compositions for the production of orthogonal trna-aminoacyl trna synthetase pairs: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.... Agent: The Scripps Research Institute
20130309721 - Solutions of mannoproteins and their use: The present invention describes a mannoprotein solution which has a turbidity, when measured by nephelometry at a concentration of 200 g/l of mannoprotein and at a pH in the range of pH 4 to pH 8 lower than 70 NTU, preferably lower than 60 NTU, more preferably lower than 50... Agent: DsmIPAssets B.v.
20130309722 - Use of browned glucose as a feed substrate: A method for fermenting a microorganism, producing a compound of interest, in a culture medium comprising: adding a browned glucose solution to the culture medium, wherein the browned glucose solution is a glucose solution that has been acid treated and heated to a temperature of at least 90 degrees Celsius,... Agent: Novozymes A/s
20130309723 - Methods for degrading or converting cellulosic material: Provided are methods for degrading or converting a cellulosic material, comprising: treating the cellulosic material with an enzyme composition in the presence of a polypeptide having catalase activity; and enzyme composition used for degrading or converting a cellulosic material comprising one or more (e.g., several) enzymes having cellulolytic and/or hemicellulolytic... Agent: Novzymes A/s
20130309724 - Step-up method for cold-pcr enrichment: Methods of using polymerase chain reactions to enrich a target sequence in a sample containing reference sequences and target sequences having high homology and amplifiable by the same primer pair are provided herein. In particular the methods provide a robust means to improve the fold enrichment of the target sequence... Agent:
20130309725 - Methods and devices for in situ nucleic acid synthesis: Disclosed are compositions, methods and devices for the in situ synthesis of nucleic acids. In an exemplary embodiment, a support-bound oligonucleotide is elongated by addition of one or more nucleotides by hybridization of a partially double-stranded oligonucleotide, ligation and removal of unwanted nucleotides.... Agent: Gen9, Inc.
20130309726 - Variants of glucoamylase: The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DNA constructs... Agent: Dupont Nutrition Biosciences Aps
20130309727 - Methods and systems for processing biomass material: Embodiments of the present invention provide for efficient and economical production and recovery of ethanol or other volatile organic compounds. One embodiment comprises contacting a solid component of a biomass material with a solution adapted to facilitate saccharification. The solid component is generated by a method comprising: introducing a biomass... Agent:
20130309729 - Mutant cellobiohydrolase: The invention relates to Mutant cellobiohydrolase, being a mutant of SEQ ID NO:1, having a substitution at position N247(I,F,H,W) of SEQ ID NO: 1, wherein the mutant cellobiohydrolase has at least 50% sequence identity with SEQ ID NO: 1, and wherein the mutant cellobiohydrolase has CBHI activity.... Agent: DsmIPAssets B.v.
20130309728 - Process for producing hemicellulose sugars and energy from biomass: A method for the production of alcohol and other bioproducts hemicelluloses extracted from biomass prior to thermal conversion of the biomass to energy. The process can be integrated with the host plant process to minimize the energy loss from extracting hemicelluloses. Also disclosed is a Stepwise enzymatic break down of... Agent: Api Intellectual Property Holdings, LLC
20130309730 - Laccases and uses thereof: The present invention relates to novel enzymes and the uses thereof. The invention also relates to methods of producing such enzymes, coding nucleic acid molecules, recombinant cells and methods of modifying biomass from such materials. The invention is particularly suited to degrade biomass and/or to improve biomass degradation. The invention... Agent: Deinove
20130309731 - Method for manufacturing red mold dioscorea: The present invention discloses a method for manufacturing red mold dioscorea, and the method comprises the following steps: washing and cutting a fresh dioscorea into pieces with a specific dimension; drying the pieces of the fresh dioscorea for making the dried dioscorea contain a specific water content and a specific... Agent: Sunway Biotech Co., Ltd.
20130309732 - Biosynthesis methods of norephedrine with specific optical activities: A biosynthesis method of norephedrine with specific optical activities is revealed to convert and generate optical isomers with specific optical activities by biocatalysis. A two-step biotransformation reaction is carried by a whole-cell biocatalyst for converting reaction substrates, benzaldehyde and pyruvate, to L-phenylacetylcarbinol (L-PAC) in the first step and the yield... Agent: Hungkuang University
20130309734 - Engineered amine dehydrogenases and methods of use thereof: Non-naturally occurring amine dehydrogenases (AmDH) and methods of use thereof the produce chiral amines are disclosed. The AmDH are variants of amino acid dehydrogenases. AmDH based on phenylalanine, leucine, and valine scaffolds are provided. The AmDH typically have one, two, three, four, or more amino acid alterations relative to the... Agent: Georgia Tech Research Corporation
20130309733 - Stabilized recombinant expression plasmid vector in hafnia alvei and applications thereof: One aspect of the present disclosure relates to a stabilized recombinant expression plasmid vector comprising a polynucleotide encoding an antitoxin gene which expresses a polypeptide that neutralizes a polypeptide toxic to a host cell, the toxic polypeptide being expressed by a toxin gene in the host cell, and a polynucleotide... Agent: Cathay Industrial Biotech Ltd.
20130309735 - Process for producing volatile organic compounds from biomass material: Embodiments of the present invention provide for efficient and economical production and recovery of ethanol or other volatile organic compounds, such as acetic acid, from solid biomass material, particularly on a larger scale, such as on the commercialization or industrial scale. According to one aspect of the invention, the method... Agent: Shell Oil Company
20130309736 - Compositions and methods for malate and fumarate production: The present application provides genetically modified yeast cell comprising an active malate fermentation pathway and/or an active fumarate fermentation pathway, as well as methods of using these cells to produce malate and/or fumarate.... Agent: Cargill, Incorporated
20130309737 - Method for the preparation of 1,3-propanediol from sucrose: The invention also concerns a new method for the biological preparation of 1,3-propanediol by fermentation, comprising cultivating said microorganism genetically modified, wherein the culture is performed in an appropriate medium comprising a source of sucrose, and recovering the 1,3 -propanediol being produced. In a preferred aspect of the invention, the... Agent: Metabolic Explorer
20130309738 - Processes and systems for alcohol production and recovery: The present invention relates to processes for recovering butanol produced in a fermentative process using, for example, an ethanol production plant which has been reversibly-retrofitted for butanol production, that is, the ethanol production plant may be converted for butanol production, but can also revert to an ethanol production. The present... Agent: Butamax Advanced Biofuels LLC
20130309739 - Methods and systems for processing biomass material: Embodiments of the present invention provide for efficient and economical production and recovery of volatile organic compounds and hydrocarbons. One embodiment comprises contacting a solid component of a biomass material with a solution adapted to facilitate saccharification, and contacting the at least one fermentable sugar with a microorganism capable of... Agent: Shell Oil Company
20130309743 - Conversion of prenyl derivatives to isoprene: The present invention provides methods for producing derivatives from cultured cells. In addition, the present invention provides methods for conversion of prenyl derivatives, obtained from biological or petrochemical sources, to isoprene by employing chemical or biological catalysts. The present invention also provides compositions that include the cultured cells or isoprene... Agent: Danisco US Inc.
20130309741 - Microorganisms and processes for the production of isoprene: The present invention provides a novel biosynthetic pathway for the production of isoprene from 3-methyl-2-buten-1-ol or 2-methyl-3-buten-2-ol. Further embodiments provide non-naturally occurring microorganism that have been modified to produce isoprene from 3-methyl-2-buten-1-ol or 2-methyl-3-buten-2-ol and methods of producing isoprene using said microorganism.... Agent: Glycos Biotechnologies, Inc.
20130309742 - Microorganisms and processes for the production of isoprene: The present invention provides a novel biosynthetic pathway for the production of isoprene from 3-methyl-2-buten-1-ol or 2-methyl-3-buten-2-ol. Further embodiments provide non-naturally occurring microorganism that have been modified to produce isoprene from 3-methyl-2-buten-1-ol or 2-methyl-3-buten-2-ol and methods of producing isoprene using said microorganism.... Agent: Glycos Biotechnologies, Inc.
20130309740 - Two-stage anaerobic digestion systems wherein one of the stages comprises a two-phase system: Low cost, efficient two-stage anaerobic digestion systems for the production of biogas (e.g. methane) are provided. During the first stage, biogas is produced in a first reactor by anaerobic microbes cultured in two phases: a high solids phase and a low solids phase. During the second stage, biogas is produced... Agent: Washington State University Research Foundation
20130309744 - Mutant microorganism with enhanced sugar utilization and methods for preparing the same: The present invention relates to a mutant microorganism with enhanced sugar utilization and methods for preparing the same. The mutant strain is capable of effectively utilizing various sugars including cellobiose and xylose, and can thus be useful in the production of biofuels, physiologically active materials, medicinal materials or industrial chemicals... Agent: Unist Academy-industry Research Corporation
20130309745 - Porous structure for forming an anti-fingerprint coating, method for forming an anti-fingerprint coating using the porous structure, substrate comprising the anti-finger-print coating formed by the method, and products comprising the substrate: Provided are a porous structure for forming anti-fingerprint coating capable of providing a self-cleaning function to a surface of a substrate, a method of forming anti-fingerprint coating using the same, an anti-fingerprint coated substrate prepared by the same method, and a product including the same. When the porous structure including... Agent:
20130309746 - Biodegradable immobilized enzymes and methods of making the same: The present application discloses immobilized enzymes and immobilized enzyme materials comprising a crosslinked enzyme having a support material which includes a biomass material different than the biomass used to initially derive the enzyme. Optionally, the immobilized enzyme further includes a polymeric material and/or the biomass which was used to initially... Agent:
20130309748 - Enzymatic conversion of volatile organic compounds: The present invention relates to a composition comprising a stable aqueous dispersion of polymer particles, an oxidoreductase, and a cofactor for the oxidoreductase and a method for its preparation. The invention is useful for converting certain classes of VOCs to non-VOCs.... Agent:
20130309747 - Mgmt-based method for obtaining high yeilds of recombinant protein expression: The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 18.104.22.168), a mutant or a catalytic domain thereof, and... Agent:
20130309749 - Nucleic acid encoding n-methylputrescine oxidase and uses thereof: The gene encoding N-methylputrescine oxidase (MPO) and constructs comprising such DNA are provided, including methods of regulating MPO expression independently or with other alkaloid biosynthesis genes to modulate alkaloid production in plants and host cells. MPO genes or fragments thereof are useful for reducing pyrrolidine or tropane alkaloid production in... Agent: National Research Council Of Canada
20130309750 - E. coli transformant, method for producing flavin-bound glucose dehydrogenase using the same, and mutant flavin-bound glucose dehydrogenases: A flavin-bound glucose dehydrogenase (FAD-GDH) with high substrate specificity for D-glucose. A gene encoding a mutant FAD-GDH with its N-terminal region, containing an amino acid sequence corresponding to MKITAAIITVATAFASFASA that exists in the N-terminal region, deleted from the amino acid sequence of a wild-type FAD-GDH derived from Mucor is introduced... Agent:
20130309751 - Polypeptides having phospholipase c activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having phospholipase C activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s
20130309752 - Polypeptides having colanic acid-degrading activity: The present disclosure generally relates to polypeptides having colanic acid-degrading activity and methods of using the same. Polynucleotides encoding such polypeptides are also described. The polypeptides may be used, for example, in processes for degrading colanic acid, processes for the removal of endotoxins from biological samples, and processes for purifying... Agent: Gradalis, Inc,
20130309753 - Recombinant auto-activating protease precursors: A recombinant serine protease precursor that auto-activates in an aqueous buffer to form a mature active enzyme is disclosed. A contemplated precursor contains 1 to about 10 heterologous amino acid residues that function to enhance by at least ten-fold the room temperature rate of auto-lytic bond cleavage to form the... Agent: Saint Louis University
20130309754 - Porphyrin containing lactic acid bacterial cells and use therof: Culturally modified lactic acid bacterial cells containing a porphyrin compound and their use in a novel method of reducing the oxygen content in a food and feed product or starting material is provided and means of improving the shelf life and/or quality of such products by using the culturally modified... Agent: Chr. Hansen A/s
20130309755 - Fungal leachate and method of making same: A method of producing a fungal leachate solution comprises the steps of obtaining a feedstock of lignocellulosic substrate; colonizing the substrate with a selected fungus; and adding water to the colonized substrate to form a liquid medium containing at least one of sugar alcohol, a phenolic compound and a fatty... Agent:
20130309756 - Method and apparatus for extracting carbon dioxide from air: A method and apparatus for extracting CO2 from air comprising an anion exchange material formed in a matrix exposed to a flow of the air, and for delivering that extracted CO2 to controlled environments. The present invention contemplates the extraction of CO2 from air using conventional extraction methods or by... Agent: Kilimanjaro Energy, Inc.
20130309757 - Method and apparatus for producing cells and fat soluble materials by cell culture: The present invention relates to a method and apparatus for producing cells without injury and fat-soluble materials by from cell culturing in an inexpensive and highly efficient manner. The apparatus according to the present invention comprises a culturing device 10, a solvent device 20, a mixing device 30, a separation... Agent:
20130309758 - Apparatus and method for conducting microbiological processes: A method and apparatus are provided for conducting a microbiological process on a bulk material in which a quantity of the bulk material is loaded onto a waterproof lining forming part of a bio cell with a heat transfer arrangement below the quantity of bulk material or within its volume,... Agent: University Of The Free State
20130309759 - Methods and apparatuses for removal of hydrogen sulfide and carbon dioxide from biogas: Methods, systems and apparatuses herein provide a unique and novel process to remove H2S from biogas. Methods, systems and apparatuses herein provide a unique and novel process to remove H2S from biogas with ease of operation and reduced operating and capital costs. Methods, systems and apparatuses herein provide a unique... Agent:
20130309760 - Assay device: The present invention relates generally to an assay device with improved tolerance to mishandling and/or use by the user. More particularly, the invention relates to an assay device with reduced susceptibility to flooding.... Agent: Spd Swissprecicion Diagnostics Gmbh
20130309761 - Apparatus for producing saccharide solution that uses biomass as feedstock: There is provided an apparatus for treating a biomass feedstock at a high temperature, including a cooling means for cooling a biomass treated liquid at a high temperature; an enzymatic saccharification tank for saccharifying a cooled treated liquid with an enzyme; a solid-liquid separation apparatus for removing water-slightly soluble substances... Agent: Toray Industries, Inc.
20130309762 - Photobioreactor made of a transparent film: The photobioreactor according to the present invention is advantageous in that the reaction vessel in which photosynthesis occurs is a plate-type and made of a transparent film, thus achieving improved light transmittance and mobility, and enabling the economically advantageous manufacture and operation thereof. Therefore, the photobioreactor of the present invention... Agent: Sungkyunkwan University Foundation For Corporate Collaboration
20130309764 - Apparatus for removal of specific seed tissue or structure for seed analysis: An apparatus for reducing resources for selecting seed to be produced in commercial quantities or for research is disclosed. Samples of seed which are candidates for selection are collected and given an identifier. Specific tissue or structure from candidate seed is removed. A test or analysis is performed on the... Agent: Pioneer Hi-bred International, Inc.
20130309763 - Sample feeding apparatus, flow cytometer, and sample feeding method: A sample feeding apparatus includes a first cylinder, a second cylinder, and a sealing section. The first cylinder is configured to be mounted with a sample tube. The second cylinder is configured to move the first cylinder between a first position and a second position, the first position being for... Agent: Sony Corporation
20130309765 - Modified tamavidin: The present invention provides modified tamabidin 2, which is a modified biotin-binding protein comprising an amino acid sequence represented by SEQ ID NO: 2, an amino acid sequence having one or more amino acid mutations in the amino acid sequence of SEQ ID NO: 2, or an amino acid sequence... Agent: Japan Tobacco Inc.
20130309766 - Endogenous and non-endogenous versions of human g protein-coupled receptors: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown, and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.... Agent: Arena Pharmaceuticals, Inc.
20130309768 - Method for culturing human pluripotent stem cells: An aim of the present invention is to provide a method for culturing a human pluripotent stem cell while maintaining an undifferentiated state, more efficiently than conventional methods, and a kit therefor. The pluripotency of a stem cell was found to be maintained at a high rate, regardless of experimenter's... Agent: National Institute Of Biomedical Innovation
20130309767 - Methods and compositions for enhancing the efficacy and specificity of rna silencing: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are... Agent: University Of Massachusetts
20130309770 - Scaffolds and other cell-growth structures using microfluidics to culture biological samples: Methods and apparatuses for using microfluidics to generate bubbles and using the generated bubbles to construct scaffolds and cell-holding structures for culturing biological samples or analytes. In one implementation, a scaffold for growing cells is provided to include a matrix of interconnected cavities formed from mixing a gas and a... Agent:
20130309771 - Bioreactor system: Disclosed herein are bioreactor systems and methods of utilizing said systems.... Agent: Kiyatec Inc.
20130309772 - Method for transformation of stramenopile: To provide a transformation method for producing a stramenopile organism having an improved unsaturated fatty acid production capability by disrupting a gene of the stramenopile organism or inhibiting the expression of the gene in a genetically engineering manner. [Solution] A method for transforming a stramenopile organism, which comprises disrupting a... Agent: University Of MiyazakiPrevious industry: Education and demonstration
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