Chemistry: molecular biology and microbiology inventions

20090263780 - Organ preservation fluid: Novel organ preservation fluids, as well as related articles and methods, are disclosed.... Agent: Yanming Wang

20090263781 - Composition for preserving platelets and method of using the same: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally,... Agent: Morris Manning Martin LLP

20090263782 - Reaction apparatus: An apparatus 20 for biological or chemical reactions, in particular PCR, includes a heat removal module 22 adapted to receive snugly a reaction vessel 24 in such a manner as to create good thermal conductivity contact between the module and the vessel. The heat removal module 22 is formed of... Agent: J. Bruce Hoofnagle

20090263783 - Nucleic sequence and deduced protein sequence family with human endogenous retroviral motifs, and their uses: The present invention provides a translational product encoded by the nucleotide sequence of SEQ ID NO: 2, which corresponds to the gag gene of an endogenous human retrovirus named HERV-7q. The present invention also provides methods for diagnosing a neurological or autoimmune disease in a patient.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090263784 - Three-dimensional structure of prostaglandin d synthase and utilization thereof: A method of designing an anti-allergic agent, sleep controlling agent, anti-obesity agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090263787 - method for screening of infectious agents in blood: This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of infectious agent related antibodies and/or antigens in a serum sample, which can be used to screen for infectious agents in blood. It also discloses an efficient formula to make a mixed SAM that can greatly enhance... Agent: Weili Cheng

20090263788 - Efficient algorithm for pcr testing of blood samples: Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level. Samples are formed into pools which are subsequently tested for virus contamination by a high-sensitivity test such as PCR. The... Agent: Kauth , Pomeroy , Peck & Bailey ,llp

20090263786 - Mass spectrometric analysis method: Methods of using mass spectrometry and in particular matrix assisted laser Ligand-Complex from Target and desorption-ionization (MALDI) mass spectrometry to analyze, or otherwise detect the presence of or determine the identity of intact ions of undigested, unfragmented covalently stabilized supramolecular target-ligand-complexes, as well as the use of these methods in... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090263785 - Modified hiv-1 peptides and use thereof in the detection of anit-hiv antibodies: The invention relates to synthetic peptides having sequence (III), which are derived from HIV-1 virus gp41 and which can be used in immunoassays for the detection of infections caused by HIV-1 viruses. The invention also relates to the method of preparing said peptides, to compositions and kits containing same and... Agent: Jacobson Holman PLLC

20090263799 - Assay for prostate cancer: In certain embodiments, a method for detecting a prostate proliferative cell disorder, a prostate cancer or a prostate tumor and/or categorizing Gleason's Sum of the tumors includes performing a digital rectal examination on a subject; obtaining one or more expressed prostatic secretion (EPS) samples from the subject; measuring PSA levels... Agent: Perkins Coie LLP

20090263792 - Atopic dermatitis marker and technique of using the same: It is an object of the present invention to find substances that can be used as disease markers for atopic dermatitis and the present invention provides a method for determining atopic dermatitis, including measurement of the expression of specific proteins and/or their genes in skin cells and/or skin tissues, wherein... Agent: Knobbe Martens Olson & Bear LLP

20090263804 - Biomarkers for aging: A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified multiple groups of genes expressed in the hippocampi of mammals, where the genes were expressed at different levels for several ages. The aging changes in... Agent: Mcdermott Will & Emery LLP

20090263810 - Bisulfite conversion of dna: The present invention provides an improved method for the bisulfite conversion of DNA, and facilitates the analysis of cytosine methylation of genomic DNA. Novel combinations of denaturing solvents, new reaction conditions and new purification methods provide surprisingly efficacious methods for bisulfite conversion of DNA relative to prior art methods. The... Agent: Dla Piper LLP (us)

20090263815 - Cell culture system, process for the production thereof, and the use thereof in preclinical investigation: The invention relates to a cell culture system, in particular for the preclinical testing of active substances, comprising a first and a second compartment which are in communication with one another via a separating layer between the first and the second compartment, the separation layer being permeable for cellularly secreted... Agent: Knobbe Martens Olson & Bear LLP

20090263791 - Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods: This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3′-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods... Agent: Cooper & Dunham, LLP

20090263795 - Diagnostic methods involving determining gene copy numbers and snps in the fcyrii/fcyriii gene cluster, and probes for use in such methods to detect susceptibility to and treatment efficacy in autoimmune diseases: The invention relates to diagnostic methods to predict whether a subject is predisposed for acquiring a disease or to predict the therapy responsiveness of an individual patient. Provided is a method for determining whether a subject is predisposed for developing an autoimmune disease, comprising determining in a sample isolated from... Agent: Hoffmann & Baron, LLP

20090263819 - Gene and protein expression profiles associated with the therapeutic efficacy of egfr-tk inhibitors: The present invention provides protein and gene expression profiles indicative of whether a patient afflicted with non-small cell lung cancer is likely to be responsive to treatment with a therapeutic compound that is a EGFR-TK inhibitor. By identifying such responsiveness, a treatment provider may determine in advance those patients who... Agent: Nuclea Biotechnologies, LLC

20090263808 - Genetic analysis for stratification of cancer risk: The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of two or more genes, in combination, to identify individuals with increased or decreased risk of cancer. Exemplified is risk assessment for breast cancer in women. In addition, personal... Agent: Fulbright & Jaworski L.L.P.

20090263794 - High throughput flow through sample preparation using magnetic beads: A polymerase chain reaction system for analyzing a sample containing nucleic acid includes providing magnetic beads; providing a flow channel having a polymerase chain reaction chamber, a pre polymerase chain reaction magnet position adjacent the polymerase chain reaction chamber, and a post pre polymerase magnet position adjacent the polymerase chain... Agent: Lawrence Livermore National Security, LLC

20090263816 - Labelled beads: A labelled polymeric bead wherein individual beads comprise a primary particle formed of a synthetic polymeric material, and at least one secondary particle entrapped within the primary particle of the bead and being comprised of a synthetic polymer material incorporating reporter moieties.... Agent: Goodwin Procter LLP Patent Administrator

20090263806 - Method for detecting chikungunya virus: Compositions, methods and kits for detecting Chikungunya viral nucleic acids. Particularly described are methods for detecting very low levels of the viral nucleic acids using nucleic acid amplification.... Agent: Gen Probe Incorporated

20090263789 - Method for detecting nucleic acid sequences: The invention is directed to a method for detecting a target nucleic acid sequence by non-linear amplification.... Agent: Cheryl H Agris Phd

20090263798 - Method for identification of novel physical linkage of genomic sequences: The invention is directed to methods to identify the location in a genome of a nonfixed or multicopy genomic element using microarrays or sequencing.... Agent: Connolly Bove Lodge & Hutz, LLP

20090263818 - Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by ugt1a1 enzyme or whose metabolic intermediate is metabolized by the enzyme: A method of estimating a risk of the expression of an adverse drug reaction caused by the administration of irinotecan, and a method of reducing the adverse drug reaction caused by the administration of irinotecan. A polymorphism on the basis of a difference in the repeating numbers of TA repetitive... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20090263800 - Methods and compositions for diagnosing and monitoring transplant rejection: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same... Agent: Morrison & Foerster LLP

20090263796 - Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases: Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or... Agent: Morrison & Foerster LLP

20090263802 - Methods and compositions for efficient base calling in sequencing reactions: The present invention is directed to methods and compositions for acquiring nucleotide sequence information of target sequences. In particular, the present invention provides methods and compositions for improving the efficiency of sequencing reactions by using fewer labels to distinguish between nucleotides and by detecting nucleotides at multiple detection positions in... Agent: Morgan, Lewis & Bockius, LLP

20090263817 - Methods for diagnosing and treating systemic lupus erythematosus disease and compositions thereof: The present invention is directed to novel methods for diagnosis and prognosis of Systemic lupus erythematosus by identifying differentially expressed genes. Moreover, the present invention is also directed to methods that can be used to screen test compounds and therapies for the ability to inhibit systemic lupus erythematosus. Additionally, methods... Agent: Wyeth Patent Law Group

20090263809 - Methods for identification of bioagents: Methods for detecting and identifying known and unknown bioagents, particularly bacteria, by nucleic acid amplification and amplicon size determination are provided. Nucleic acid amplification utilises multiple primers which hybridize to conserved bioagent ribosomal sequence regions and which bracket variable bioagent ribosomal sequence regions to produce multiple amplicons that uniquely identify... Agent: Morrison & Foerster LLP

20090263790 - Methods for identifying functionally related genes and drug targets: The identification and evaluation of mRNA and protein targets associated with mRNP complexes and implicated in the expression of proteins involved in common physiological pathways is described. Effective targets are useful for treating a disease, condition or disorder associated with the physiological pathway.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20090263805 - Methods of identifying point mutations in a genome that affect the risk for or the age of appearance of disease: The invention relates to a method for identifying inherited point mutations in a targeted region of the genome in a large population of individuals and determining which inherited point mutations are deleterious, harmful or beneficial. Deleterious mutations are identified directly by a method of recognition using the set of point... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090263803 - Mirnas differentially expressed in lymph nodes from cancer patients: The present invention provides diagnostics and/or prognostic methods by identifying miRNAs that are differentially expressed or mis-regulated in various states of diseased, normal, cancerous, and/or abnormal tissues, including but not limited to cervix, skin, colon, breast, bladder, esophagus, liver, ovary, prostate, lung, pancreas, thyroid, kidney, stomach, testicle, uterus, spleen, tongue,... Agent: Fullbright & Jaworski L.L.P.

20090263793 - Novel method for diagnosing of mycobacterium tuberculosis: The present invention relates to a method and a kit for detecting Mycobacterium tuberculosis (MTB) or Nontuberculous mycobacteria (NTM) of patients. The present invention also relates to primers and probes used to detect Mycobacterium tuberculosis (MTB) or Nontuberculous mycobacteria (NTM) by performing PCR.... Agent: Wpat, PC Intellectual Property Attorneys

20090263807 - Optical detection field having diamond-like carbon thin film formed therein: An optical detection field, wherein a diamond-like carbon thin film containing therein fluorine is formed on a surface facing an existence region of a substance.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090263820 - Optimization of gene expression analysis using immobilized capture probes: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target “engineering”, as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers... Agent: Eric P. Mirabel

20090263801 - Phenotype-genotype relationship in age-related macular degeneration: Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take... Agent: Banner & Witcoff, Ltd.

20090263814 - Physiogenomic method for predicting metabolic and cardiovascular side effects of thiazolidinediones: Disclosed herein are genetic markers related to the efficacy and/or safety of thiazolidinedione therapy identified by a physiogenomic methodology that correlates the genetic markers with a physiological response. The genetic markers described herein were not previously associated with the efficacy and/or safety of thiazolidinedione therapy. The markers related to safety... Agent: Cantor Colburn, LLP

20090263797 - Reversible di-nucleotide terminator sequencing: The present teachings provide methods, compositions, and kits for synthesizing and sequencing nucleic acids. In some embodiments, reversible di-nucleotide compounds are employed along with cleaving reactions that remove a label and a blocking moiety. Improved sequencing efficiency is achieved by the rapid polymerase-mediated incorporation of reversible di-nucleotide compounds. In some... Agent: Life Technologies Corporation C/o Intellevate

20090263813 - Ribonucleotide tag nucleic acid detection: The present application provides polynucleotides comprising 5′-tails with sequence segments useful for the detection of target nucleic acid sequences, and methods for their use in detecting target nucleic acids. The polynucleotides are used to amplify a subsequence of a target nucleic acid in the presence of one or more ribonucleotides.... Agent: Townsend And Townsend And Crew, LLP

20090263811 - Target base discrimination method: A target base-specific primer for use in discrimination of the base type of a target base in a nucleic acid in a nucleic acid sample, which is capable of discriminating the target base clearly with less possibility of false positive, and a target base discrimination method using the target base-specific... Agent: Scully Scott Murphy & Presser, PC

20090263812 - Use of id4 for diagnosis and treatment of cancer: The invention relates to a method of determining whether a human subject is suffering from or at risk for developing pancreatic cancer by determining the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a biological sample from a human subject. Also disclosed... Agent: Hogan & Hartson L.L.P.

20090263824 - Detection of neurodegenerative disease: Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods for diagnosing a neurodegenerative disease in a subject, and methods for determining the efficacy of a drug against a neurodegenerative... Agent: Woodcock Washburn LLP

20090263823 - Glyceroglycolipid antigen of mycoplasma pneumoniae: The present invention provides a novel glyceroglycolipid produced by Mycoplasma pneumoniae. The glyceroglycolipid can be used as a diagnostic marker for a disease caused by Mycoplasma pneumoniae.... Agent: Foley And Lardner LLP Suite 500

20090263822 - In vitro procedure for diagnosis and early diagnosis of neurodegenerative diseases: An in vitro process for the detection and early detection of neurodegenerative diseases, for determination of the severity, and to evaluate the progression of and render a prognoses of neurogenerative diseases, in a patient suffering from a subjectively or objectively detectable cognitive impairment, by determining the concentration of an analyte... Agent: Heslin Rothenberg Farley & Mesiti PC

20090263826 - Means and method for diagnosing hemolytic anemia: The present invention relates to a method for diagnosing hemolytic anemia or a predis-position thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present... Agent: Connolly Bove Lodge & Hutz, LLP

20090263827 - Method for determining health status by analyzing analytes: A method to extract information from samples taken at different times from a mammalian. These samples are analyzed with respect to one or more analytes giving one or more responses, creating one or more response curves. From this/these response curves is/are changes in the responses calculated as slope, curvatures or... Agent: Frishauf, Holtz, Goodman & Chick, PC

20090263825 - Methods, immunoassays and devices for detection of anti-lipoidal antibodies: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a solid support (such as a nitrocellulose membrane) is described. The ability to immobilize a... Agent: Klarquist Sparkman, LLP

20090263821 - Ubiquitin ligase assays and related reagents: The disclosure provides, inter alia, methods and reagents for use in measuring the attachment of ubiquitin and ubiquitin-like proteins to a target protein, particularly an E3 protein.... Agent: Ropes & Gray LLP

20090263828 - Novel assay for precursor t-cells having high proliferative capacity (phpc-asay): Diagnostic assay of antigen-specific T-cell precursors to determine the immunological status of patients suffering in chronic infectious diseases and to anticipate the disease progression and the response to therapy... Agent: The Law Offices Of Valerie E. Looper

20090263835 - Genes that are up- or down-regulated during differentiation of human embryonic stem cells: Genes that are up- or down-regulated during differentiation provide important leverage by which to characterize and manipulate early-stage pluripotent stem cells. Over 35,000 unique transcripts have been amplified and sequenced from undifferentiated human embryonic stem cells, and three types of differentiated progeny. Statistical analysis of the assembled transcripts identified genes... Agent: Geron Corporation Attn. David J. Earp

20090263836 - Botulinum toxin screening assays: Methods for detecting BoNT/A activity in a sample, methods for screening molecules able to compete with BoNT/A receptor binding, methods for reducing BoNT/A activity in a human and methods of marketing a neurotoxin capable of selectively binding to a FGFR2, a FGFR3, a SV2, or any combination thereof, to a... Agent: Allergan, Inc.

20090263829 - Alzheimer's disease biomarkers and methods of use: The invention encompasses biomarkers for AD, a method for detecting AD, a method of monitoring AD, and a kit for quantifying biomarkers for AD.... Agent: Polsinelli Shughart PC

20090263830 - Visualization and quantitiation of cellular cytotoxicity using cell-permeable fluorogenic protease substrates and caspase activity indicator markers: This invention provides a non-radioactive assay to monitor and quantify the target-cell killing activities mediated by cytotoxic T lymphocytes (CTLs). This assay is predicated on the discovery that apoptosis pathway activation and, in particular, caspase activity, provides a measure of cytotoxic effector cell activity. In one embodiment, measurement of CTL-induced... Agent: Weaver Austin Villeneuve & Sampson LLP

20090263833 - In vitro estimation of in vivo half-life binding proteins: The present invention discloses methods used to estimate the in vivo half-life of a binding protein of interest. The disclosed methods involve (a) determining for a binding protein of interest and for each of at least two different reference binding proteins an in vitro half-life using an in vitro protease... Agent: Kenneth P. Zwicker, Esq. Abbott Bioresearch Center

20090263832 - Reagents for the detection of protein phosphorylation in leukemia signaling pathways: The invention discloses nearly 123 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20090263831 - Ubiquitin ligase assay: The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.... Agent: Klarquist Sparkman, LLP

20090263834 - Droplet actuator devices and methods for immunoassays and washing: Droplet actuator devices and methods for immunoassays and washing are provided. According to one embodiment, a method of providing a droplet in contact with a surface of a super paramagnetic bead with a reduced concentration of a substance is provided and includes: (a) providing a super paramagnetic bead in contact... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20090263838 - Method for determining a lung cancer treatment and method for determining the effectiveness of an agent for treatment of lung cancer: The present invention provides a method of determining a lung cancer treatment, the method comprising: measuring an amount of KL-6 in a sample of body fluid from a subject, and determining the treatment based on the amount of KL-6 measured, and a method of determining the effectiveness of an agent... Agent: Taiyo Corporation

20090263837 - Method of minimizing reagent consumption in microplate-based reactions: A method is provided for performing a reaction, such as the synthesis of concentrated cDNA, in the wells of a microplate while minimizing the volume of the solution of reagents required to perform the reaction. In the method, a pestle is inserted into the well of a microplate to which... Agent: Knobbe Martens Olson & Bear LLP

20090263839 - Acetaminophen-protein adduct assay device and method: The present invention describes devices and methods for detecting and measuring the amount of acetaminophen-protein adducts in a sample.... Agent: Polsinelli Shughart PC

20090263840 - Novel monoclonal anitbody and use thereof: The present invention provides an antibody capable of specifically recognizing the same amino acid sequence as an antigenic determinant of mouse monoclonal antibody MAB-ME-16F4.3 (FERM BP-10329), and an antibody of capable of specifically recognizing the same amino acid sequence as an antigenic determinant of mouse monoclonal antibody MAB-ME-12C9.2 (FERM BP-10328),... Agent: Hogan & Hartson L.L.P.

20090263841 - Use of nnmt as a marker for lung cancer: The present invention relates to the assessment of lung cancer. It discloses the use of protein NNMT in the assessment of lung cancer. It also relates to a method for assessing lung cancer by measuring NNMT in vitro in a liquid sample derived from an individual. Measurement of NNMT can,... Agent: Roche Diagnostics Operations Inc.

20090263842 - Method of assessing the metastatic status of a primary tumor: The current invention provides a method for determining the metastatic potential, capability, status, or characteristics of a primary tumor from a human cancer patient by determining expression patterns of proteins that initiate, cause, promote, mediate, inflict, or otherwise aid metastatic properties of cells from a primary tumor. The identification of... Agent: Proskauer Rose LLP

20090263843 - Protein labeling with cyanobenzothiazole conjugates: The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the invention provides methods for labeling the N-terminus of a protein that terminates with a cysteine residue. The invention also provides methods for isolating an N-terminally labeled protein and methods for detecting... Agent: Schwegman, Lundberg & Woessner, P.A.

20090263844 - Method and kit for quantitative determination for small, dense particle low density lipoproteins: A rapid and convenient method capable of performing fractional measurement of small, dense LDLs without pretreatment of a specimen, which is adaptable for an autoanalyzer, is provided. A method for quantitatively determining small, dense LDL cholesterol is provided, which comprises adding enzymes for cholesterol measurement to a test sample in... Agent: Foley And Lardner LLP Suite 500

20090263845 - Method and kit for assessing the suitability of erythrocytes for transfusion: A method of assessing whether or not erythrocytes are suitable for transfusion into a recipient comprising (i) assaying a sample of erythrocytes for free choline, and (ii) comparing the level of free choline in the sample with the level of free choline deemed suitable for transfusion therapies; and a kit... Agent: Paul D. Yasger Abbott Laboratories

20090263846 - Oxygen-resistant hydrogenases and methods for designing and making same: The invention provides oxygen-resistant iron-hydrogenases ([Fe]-hydrogenases) for use in the production of H2. Methods used in the design and engineering of the oxygen-resistant [Fe]-hydrogenases are disclosed, as are the methods of transforming and culturing appropriate host cells with the oxygen-resistant [Fe]-hydrogenases. Finally, the invention provides methods for utilizing the transformed,... Agent: Paul J White, Patent Counsel National Renewable Energy Laboratory (nrel)

20090263856 - Apparatus and method for detecting live cells with an integrated filter and growth detection device: A device for rapid concentration and detection of live cells in fluids includes a filter to capture a cell sample. The filter includes a first physical barrier with apertures of a first size and a second physical barrier with apertures of a second size smaller than the first size to... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090263849 - Bioprinting three-dimensional structure onto microscale tissue analog devices for pharmacokinetic study and other uses: A microfluidic system for monitoring or detecting a change in a parameter of an input substance, which includes a microfluidic device having a tissue chamber and a tissue analog placed in the tissue chamber, wherein the tissue analog has a vessel structure mimicking naturally occurring vessel network incorporated in the... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20090263855 - Compositions and methods for preventing or treating inflammatory bowel disease: Compositions comprising docosahexaenoic acid (DHA) and optionally one or more fatty acids selected from the group consisting of eicosapentaenoic acid (EPA), arachidonic acid (ARA), linoleic acid (LA), and α-linoleic acid (ALA) are administered to felines for preventing or treating feline inflammatory bowel disease (IBD).... Agent: Colgate-palmolive Company

20090263853 - High-throughput cell-based cftr assay: This invention provides a high throughput screen for measuring the transport of an ion through a cystic fibrosis transmembrane conductance regulator (CFTR) of a cell that endogenously expresses CFTR. The method requires culturing the cell that endogenously expresses CFTR in the presence of an ion-sensitive compound and then contacting the... Agent: Foley & Lardner LLP

20090263851 - In vivo selection system for enzyme activity: The present invention provides in vivo systems in which activity of a biological cleavage enzyme, such as a site-specific recombinase, a homing endonuclease, or an intein, is linked to cell viability and therefore can be selected. The invention further provides methods of making cells in which the activity of a... Agent: Choate, Hall & Stewart/harvard University

20090263854 - Integrated assay device and housing: A laminated, integrated, analyte assay device and methods of using the device are described. The assay device is useful as an inexpensive, disposable assay device for detecting the presence and/or amount of a particular analyte in a body fluid or other sample.... Agent: King & Spalding LLP

20090263847 - Lsr receptor, its activity, its cloning and its applications to the diagnosis, prevention and/or treatment of obesity and related risks or complications: The present invention relates to a new complex receptor polypeptide LSR (Lipolysis Stimulated Receptor), characterized by its functional activities, the cloning of the cDNAs complementary to the messenger RNAs encoding each of the subunits of the multimeric complex, vectors and transformed cells, methods of diagnosis and of selection of compounds... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090263850 - Method and system for measuring single cell mechanics using a modified scanning probe microscope: One embodiment of the present invention provides a system that measures single cell mechanics using a scanning probe microscope. During operation, the system positions a modified probe of the scanning probe microscope above a cell which is located on a surface, wherein the modified probe is configured with a geometry... Agent: Park, Vaughan & Fleming LLP

20090263848 - Method for determining the viability of cells in cell cultures: The invention relates to a method for determining the viability of cells in cell cultures, said method comprising the steps of: colouring the sample with a dye which can penetrate into individual cells depending on the viability of the latter, determining the proportions of cells which are coloured to differing... Agent: Casella & Hespos

20090263852 - Nonapoptotic forms of cell death and methods of modulation: The invention is directed to methods for identifying molecules that modulate paraptosis, a newly identified nonapoptotic form of programmed cell death. The invention also provides a method of inhibiting paraptosis by preventing association of caspase-9 and an endogenous paraptosis-mediating molecule. In one embodiment, the invention provides a method of inhibiting... Agent: Morrison & Foerster LLP

20090263857 - Method for antigen retrieval and submersion fluid compositions for use therein: The present invention relates to a method for retrieving the antigenicity of a formaldehyde-fixed sample for immunological staining and to compositions used in such a method. A method of the invention comprises submerging a sample in a submersion fluid composition comprising an osmotically active compound and heating the said submerged... Agent: Ladas & Parry LLP

20090263858 - Process for synthesis of mucin-type peptides and muc1-related glycopeptides: The invention aims at providing novel compounds useful as primer in producing mucin-type glycopeptides which are useful in a wide field including materials for biochemical research, drugs, and food and the production of which was difficult in the prior art; and a process for the production of glycopeptides by using... Agent: Seed Intellectual Property Law Group PLLC

20090263859 - Thermophilic and thermoacidophilic glycosylation genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for glycosylating and/or post-translationally of modifying proteins using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.... Agent: Traskbritt / Battelle Energy Alliance, LLC

20090263861 - Host-vector system antibiotic-free cole1 plasmid propagation: A host-vector system that uses the RNA-based copy number control mechanism of ColE1-type plasmids for regulating the expression of a marker gene allows for antibiotic-free selection of plasmids and is useful for production of plasmid DNA and recombinant proteins.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20090263863 - Modification of protein glycosylation in methylotrophic yeast: The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable of producing glycoproteins with mammalian-like glycosylation. Glycoproteins produced from the genetically engineered methylotrophic yeast strains are also provided.... Agent: Scully Scott Murphy & Presser, PC

20090263860 - Novel 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228,... Agent: Millennium Pharmaceuticals, Inc.

20090263862 - Novel alkane polyol dehydrogenase: e

20090263864 - Recombinant production of mixtures of antibodies: The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention... Agent: Traskbritt, P.C.

20090263865 - Substance specific to human pd-1: The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein... Agent: Sughrue-265550

20090263866 - Industrial-scale serum-free production of recombinant factor vii in mammalian cells: The invention provides a method for industrial-scale production of FVII polypeptides in mammalian cell culture free of animal-derived components.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20090263867 - Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin: A method for producing a chondroitin sugar chain comprises at least the following step: a step of allowing “a glucuronic acid donor”, “an N-acetyl galactosamine donor”, “a sugar receptor” and “a bacterial cell enzyme which synthesizes chondroitin” to coexist in a reaction system in the presence of a surfactant. Here,... Agent: Knobbe Martens Olson & Bear LLP

20090263868 - Nucleotide compositions comprising photocleavable markers and methods of preparation thereof: Labelled nucleotides and polynucleotides useful in the sequencing of nucleic acids are described. Methods of preparing photocleavable marker nucleotides and photocleavable marker-polynucleotide conjugates are described. Such photocleavable marker nucleotides can be incorporated into nucleic acid so as to create photocleavable marker-polynucleotide conjugates.... Agent: Medlen & Carroll, LLP Suite 350

20090263871 - Methods and compositions for amplification of dna: The invention provides an Enzyme Blend comprising a DNA polymerase and a DNA repair enzyme. Methods and kits for amplification of DNA that is damaged, undamaged, or suspected of being damaged are also provided.... Agent: Senniger Powers LLP (sgm)

20090263869 - Methods and compositions for pcr: A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula I wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3′-5′ exonuclease... Agent: Life Technologies Corporation C/o Intellevate

20090263870 - System and method for amplifying a nucleic acid molecule: There is provided a method and/or system which allow on-chip preconditioning of complex real-world samples and/or handling of limited amounts of target material, and/or on-chip nucleic acid amplification process, using a free droplet containing magnetic attractable material. The nucleic acid amplification process comprises controlling the position of the magnetic attractable... Agent: Dinsmore & Shohl LLP

20090263872 - Methods and compositions for preventing bias in amplification and sequencing reactions: The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include template nucleic acids with stabilizing sequences. The present invention also includes concatemers formed from template nucleic acids that have stabilizing sequences, arrays of such concatemers, as well... Agent: Morgan, Lewis & Bockius, LLP

20090263873 - Linear vectors, host cells and cloning methods: Linear vectors derived from bacteriophage of E. coli and host cells suitable for cloning are provided. The linear vectors include a left arm comprising a left telomere and a first selectable marker, a right arm comprising a right telomere and a second selectable marker and a cloning region located between... Agent: Michael Best & Friedrich LLP

20090263874 - L-glutamic acid-producing bacterium and method for producing l-glutamic acid: L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Enterobacter or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutamic acid biosynthesis or which decreases in or is deficient in... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090263875 - Methods of generating protein variants with altered function: The present invention provides methods of designing and generating polypeptide variants that have altered function compared to a parent polypeptide. The present invention further provides a computer program product for carrying out the design of a variant polypeptide. The present invention further provides nucleic acids encoding terpene cyclase variants, as... Agent: Bozicevic, Field & Francis LLP

20090263876 - Hydrogen fermentor and method of producing hydrogen: The hydrogen fermentation apparatus is the one that generates hydrogen by decomposing organic matter through hydrogen fermentation. There are arranged a hydrogen fermentor which holds the treating liquid containing organic matter, and a string-shape carrier which is positioned to immerse itself in the treating liquid in the hydrogen fermentor, and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090263877 - Method of fermentation: The invention provides a process for the production of biomass by culturing a microorganism in an aqueous liquid culture medium circulating in a loop reactor having an effluent gas removal zone where from carbon dioxide-containing effluent gas is removed from the reactor and upstream thereof a degassing zone in which... Agent: Sughrue Mion, PLLC

20090263878 - Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof: The present disclosure describes mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. The ELSCs of the present disclosure are capable of proliferating in an in vitro culture, maintain the potential to differentiate into cells of endoderm, mesoderm, and ectoderm lineage in culture, and are... Agent: Vinson & Elkins, L.L.P.

20090263879 - Immunoassay for specific determination of s-adenosylmethionine and analogs thereof in biological samples: This invention pertains to a method for detecting a compound in the presence of other compounds that are substantially similar in structure and metabolically related to the analyte. The invention is particularly suited for the detection of S-adenosylmethionine in the presence of S-adenosylhomocysteine, other nucleosides and derivatives in a biological... Agent: Isac A. Angers Suite 301

20090263880 - Mutant luciferase: An object of the present invention is to provide a mutant luciferase having luciferase activity with an altered emission spectrum. A specific amino acid residue(s) is substituted in a luciferase derived from Cypridina noctiluca and then the resulting mutant luciferase having luciferase activity with an emission spectrum differing from that... Agent: Sughrue Mion, PLLC

20090263881 - Alpha-amylase mutants: The invention relates to a variant of a parent Termamyl-like α-amylase, which exhibits an alteration in at least one of the following properties relative to said parent α-amylase: i) improved pH stability at a pH from 8 to 10.5; and/or ii) improved Ca2+ stability at pH 8 to 10.5, and/or... Agent: Novozymes North America, Inc.

20090263882 - Thermostable neutral metalloproteases: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus... Agent: Kamrin T. Macknight Danisco US Inc., Genencor Division

20090263883 - Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from respiratory syncytial virus: The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products... Agent: Medimmune, LLC Patrick Scott Alban

20090263884 - Multi-action drain cleaning composition and method: The present invention relates to aspects of drain cleaning compositions, methods, and systems involving multiple levels of attack to facilitate decomposition of clogs in pipe systems. Aspects of the invention relate to a multi-action drain cleaning composition including chemical and biological components capable of producing an exothermic reaction, an oxidation... Agent: Duane Morris LLP - PhiladelphiaIPDepartment

20090263885 - Process for producing trans-4-hydroxy-l-proline: The present invention is directed to a process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090263886 - Farnesyl dibenzodiazepinone and processes for its production: This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in... Agent: Merchant & Gould PC

20090263887 - Identification, characterization, and application of pseudomonas stutzeri (lh4:15), useful in microbially enhanced oil release: The present disclosure relates to isolation and identification of unique Pseudomonas stutzeri strains that can grow on crude oil under denitrifying conditions and are useful in oil recovery.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090263888 - Koji mold-origin phospholipase a2: It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived... Agent: Edwards Angell Palmer & Dodge LLP

20090263889 - Method for increasing yield of biomass of and/or components of biomass from marine microorganisms: The present invention provides an optimized method of continuously culturing an auxotrophic marine microorganism in a fermentor under aerobic conditions at Y g/l of cell dry matter, CDM, wherein Y is in the range from 100-300 g/l, comprising culturing said auxotrophic marine microorganism in a culture medium comprising a carbon... Agent: Novozymes North America, Inc.

20090263890 - Method and equipment for reducing environmental pollution: The invention relates to a method and equipment for reducing atmospheric pollution levels, reducing the concentration of fine dust and nitric oxides. The de-polluting system is based on a synergetic combination of nitrifying and denitrifying microorganisms on suitable supports. The product can be used internally and externally, at urban and... Agent: David A. Guerra International Patent Group, LLC

20090263891 - Device for analyzing samples including a gas evolving means: The invention relates to a device for analyzing one or more samples for the presence, amount or identity of one or more target molecules in the samples, comprising one or more capture sites whereby the device comprises a gas evolving means. The gas evolved by the gas evolving means moves... Agent: Philips Intellectual Property & Standards

20090263892 - Float valve for cell culture vessel: A cell culture vessel includes a housing defining a reservoir, an inlet and an outlet in fluid communication with the reservoir, a valve assembly, and an antimicrobial filter. The valve assembly includes (i) a side wall defining a passageway for fluid flow between the reservoir and the outlet, (ii) a... Agent: Corning Incorporated

20090263893 - Flexible membrane valve for cell culture vessel: An assembly for culturing cells includes a housing defining a reservoir for containing cell culture media and an opening in fluid communication with the reservoir. The cell culture assembly further includes a filter valve assembly configured to sealingly engage the opening. The filter valve assembly includes a flexible membrane, a... Agent: Corning Incorporated

20090263894 - Antibodies that bind to mammalian ngal and uses thereof: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.... Agent: Paul D. Yasger Abbott Laboratories

20090263895 - Cell line for producing a non-retroviral vector: Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include one or more native... Agent: Enzo Biochem, Inc.

20090263896 - Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells: The present disclosure relates to compositions and methods comprising cell surface markers for hES-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hES cells.... Agent: Knobbe Martens Olson & Bear LLP

20090263897 - Reishi f3 sub fraction polysaccharides and methods of using same: The present disclosure relates to the discovery of methods of isolating subfractions of an F3 Reishi extract, and of administration of these novel isolates to eukaryotic cells in order to induce certain immumodulatory, hematopoeitic and tumor-inhibiting phenotypic changes in those eukaryotic cells, mediated through particular toll-like receptor (TLR) and other... Agent: Greenberg Traurig LLP (la)

20090263898 - Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes: Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, methods for amplification of nucleic acids and methods for delivery of the chromosomes to selected cells and tissues are... Agent: K&l Gates LLP

20090263899 - Cell modification method and cell modification device: The present invention relates to a cell modification method for modifying human or mammal immune cells, especially effector cells outside the human or mammal body, wherein in a first step at least one encapsulated substance, preferably an active pharmaceutical ingredient, is introduced in and/or arranged on isolated human or mammal... Agent: Millen, White, Zelano & Branigan, P.C.

20090263900 - Linear donor constructs for targeted integration: Disclosed herein are linear donor molecules comprising homology arms of 50-750 base pairs (e.g., 50-100 base pairs) flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest... Agent: Robins & Pasternak

20090263901 - Stable neural stem cell lines: A systematic and efficient method for establishing stable neural stem cell lines and neuronal progenitor lines is described. The resulting cell lines provide robust, simple, and reproducible cultures of human and other mammalian neurons in commercially useful mass quantities while maintaining normal karyotypes and normal neuronal phenotypes.... Agent: K&l Gates LLP

20090263902 - Method for regulating agrobacterium-mediated transformation: A method for regulating expression of a virulence gene of Agrobacterium is described. The method comprises the steps of stimulating cereal cells, such as sorghum, so as to produce an active, typically phenolic, compound and exposing the Agrobacterium to this compound. The compound induces expression of the virulence gene of... Agent: Morrison & Foerster LLP

20090258337 - Thawed organ or tissue or thawed cell group to be donated, transplanted, added, or administered to living body, production process thereof, supercooled solution therefor, and production apparatus of the organ or tissue: The present invention aims to freeze and store organs or tissues taken from human bodies or animals and after thawing, use the resulting organs or tissues, or cells taken and extracted therefrom for medical treatment. The present invention is characterized in that the organs or tissues taken from human bodies... Agent: Hedman & Costigan P.C.

20090258338 - Simulated 5-part differential leukocyte granules, the method for preparing the same and control products and calibrators comprising the same: A method for preparing five-part differential leukocyte analogs from red blood cells includes selecting appropriate red blood cells; treating the red blood cells with a multi-functional reagent system for maintenance of a structural integrity of the membranes of the red blood cells and synchronous adjustment of cell volume, morphology and... Agent: Mindray C/o Stoel Rives LLP

20090258340 - Assay for sars coronavirus by amplification and detection of the replicase sequence: Primers and probes derived from SARS-CoV nucleic acid that facilitate detection and/or quantification of the replicase gene are disclosed. The disclosed sequences may be used in a variety of amplification and non-amplification formats for detection of SARS-CoV infection.... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090258341 - Compositions and methods for detecting bacteria: Genetically modified bacteriophage and methods of using the same to detect bacterial types of interest are provided.... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20090258342 - Optimized probes and primers and methods of using same for the detection, quantification and grouping of hiv-1: Described herein are optimized primers and probes useful for detecting, quantitating and grouping variant HIV-1 strains, and methods and kits of using the described primers and probes.... Agent: Foley & Lardner LLP

20090258343 - Semi-quantitative immunochromatographic device and method for the determination of hiv/aids immune-status via measurement of soluble cd40 ligand/cd154, a cd4+ t cell equivalent and the simultaneous detection of hiv infection via hiv antibody detection: A semi-quantitative, immunochromatographic dual test device for the simultaneous detection of HIV/AIDS immune status CD4+ T cell equivalents, such as soluble CD40 ligand/CD 154, and the detection of an HIV antibody, includes one or more support materials capable of providing lateral flow. The one or more support materials include at... Agent: Bodner & O'rourke, LLP

20090258339 - Systems, methods and compositions for detection of human papilloma virus in biological samples: The present invention comprises, without limitation, systems, methods, and compositions for the detection, identification, and quantification, down to the single copy level, of human papillomavirus (HPV) in biological samples, including but not limited to, mammalian body fluids and cervix scrapings, for purposes of detection, treatment and/or management of cancer and... Agent: Casimir Jones, S.c.

20090258370 - Acute myelogenous leukemia biomarkers: The present invention provides novel compositions and their use in classifying acute myelogenous leukemia.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090258357 - Cytokine receptor common gamma chain like: The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL... Agent: Kenyon & Kenyon LLP

20090258350 - Diagnostic methods for determining prognosis of non-small cell lung cancer: The invention provides methods for identifying early stage non-small cell lung cancer (NSCLC) patients who will have a favorable prognosis for the recurrence of lung cancer after surgical resection. The invention is based on the discovery that assessment of chromosomal copy number abnormalities at two or more of chromosome 5p15,... Agent: Vysis, Inc Patent Department

20090258348 - Esterases for monitoring protein biosynthesis in vitro: The present invention relates to the use of an esterase for monitoring and/or tracking the synthesis of a protein, polypeptide or peptide in a cell-free translation system or in an in vivo expression system in which the synthesis of a protein, polypeptide or peptide can occur, wherein said monitoring and/or... Agent: Foley And Lardner LLP Suite 500

20090258349 - Method for detecting and quantifying perchlorate-reducing bacteria: The present invention provides methods, compositions, and kits for detecting and quantitating perchlorate-reducing bacteria in samples using reagents that hybridize to and allow amplification of the pcrA gene. The invention includes a quantitative real-time PCR assay for amplification of the pcrA gene which may be used to detect and quantitate... Agent: Townsend And Townsend And Crew, LLP

20090258365 - Method for detecting igf1r/chr 15 in circulating tumor cells using fish: The present invention describes methods and probe composition for an automated FISH assay of a blood sample containing circulating tumor cells expressing the IGF-1R gene. The assay provides genetic analysis of suspect circulating tumor cells that have been identified after immunomagnetic selection and fluorescent labeling. Using unique, repeat-free probes to... Agent: Philip S. Johnson Johnson & Johnson

20090258347 - Method for diagnosing and monitoring cellular reservoirs of disease: The invention provides an assay for diagnosing and/or monitoring a viral infection or disease in a patient, the assay including the steps of mixing a sample of leucocytes with a fluorescent cell membrane-permeable dye which stains RNA or both DNA and RNA within the leucocytes; identifying from all the leucocytes... Agent: Ratnerprestia

20090258360 - Method of detecting equine polysaccharide storage myopathy: The present invention relates to diagnosing Polysaccharide Storage Myopathy (PSSM) disease in equines.... Agent: Viksnins Harris & Padys Pllp

20090258364 - Method of determining the sensitivity of cancer cells to egfr inhibitors including cetuximab, panitumumab and erlotinib: (b) Determining if said cells contain a biomarker that is predictive of a therapeutic response to response to treatment with cetuximab or panitumumab. The biomarker is the mutation status of the PIK3CA gene and the expression status of the PTEN gene. Tumors that harbor activating mutations in Exon 9 and... Agent: Hedman & Costigan P.C.

20090258367 - Method of mapping of mrna distribution with atomic force microscopy: The present invention relates to a method of mapping of mRNA distribution, comprising the steps of a preparing a probe DNA attached to a apical liner region of the dendron on AFM cantilever where the probe DNA can specifically hybridize a target mRNA and measuring specific adhesive force between the... Agent: Jhk Law

20090258346 - Method of selecting sunflower genotypes with high oleic acid content in seed oil: The present invention relates to the selection of sunflower genotypes with high oleic acid content in seed oil. The invention concerns more particularly molecular markers useful for a rapid and easy selection of sunflower lines and then sunflower hybrids capable of producing seeds having high oleic acid content.... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090258351 - Methods and reagents for combined pcr amplification: An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease activity of a polymerase and the... Agent: Life Technologies Corporation C/o Intellevate

20090258358 - Methods for diagnosing and treating kidney and colorectal cancer: Methods, reagents and kits for diagnosing and treating cancer such as kidney or colorectal cancer are disclosed. An immunoassay for detecting kidney or colorectal cancer is based on the relative change of the ADAMTSL4 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney or... Agent: King & Spalding LLP

20090258354 - Methods for dna length and sequence determination: Methods for determining nucleic acid length and sequence variation are provided, for example, between an unknown sample and a reference sample. In various embodiments, a method amplifies one or more specific regions of an oligonucleotide molecule in a sample comprising oligonucleotide molecules to produce a sample of amplicons, the sample... Agent: Bozicevic, Field & Francis LLP

20090258344 - Methods for identifying risk of breast cancer and treatments thereof: Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments... Agent: Grant Anderson LLP C/o Portfolioip

20090258359 - Modular compositing-multiple lot screening protocols for detection of pathogens, microbial contaminants and/or constituents: Provided are methods for sampling, testing and validating test lots, comprising: assembling a plurality of product portions from each of a plurality of test lots and combining the portions to provide a corresponding set of test lot samples; enriching the test lot samples; removing portions of each enriched sample, and... Agent: Davis Wright Tremaine, LLP/seattle

20090258356 - Modulators of the transporter abcd3 for treating acne or hyperseborrhea: An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the peroxisome membrane transporter 1 comprising a type 3 ATP-binding site of the sub-family D (ABCD3), and... Agent: Buchanan, Ingersoll & Rooney PC

20090258355 - Nanoscale clusters and methods of making same: The present invention is a method of making a nanocluster. The method comprises providing a surface comprising at least one anchoring biomolecule, wherein the surface is in a solution; adding an initial recognition-nano-component to the solution wherein the initial recognition-nano-component comprises i) a nanoparticle and one specifically-bindable-biomolecule, or ii) a... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20090258369 - Over-expression and mutation of a tyrosine kinase receptor fgfr4 in tumors: This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly FGFR4 variants, which are linked to increased risk of tumor metastasis. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and... Agent: Klarquist Sparkman, LLP

20090258368 - Paramagnetic nucleation nanoparticles: A nucleic acid binding substance which has affinity for nucleic acid polymers. The nucleic acid binding substance is comprised of a nucleic acid binding element capable of specific binding to nucleic acid molecules and connected to a nucleation nanoparticle having paramagnetic properties.... Agent: Hiscock & Barclay, LLP

20090258353 - Pcr primer capable of reducing non-specific amplification and pcr method using the pcr primer: The present invention relates to a PCR primer facilitating hot-start PCR by suppressing non-specific amplification at room temperature and at the same time capable of reducing significantly non-specific amplification by dominating the amplification of the PCR product rather than the amplification of the original template from the third PCR cycle,... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090258366 - Pcryptornai: A vector developed to transform fungi can be used to study the expression of a gene of interest. The vector can provide for the expression of signal proteins in fungi that can be observed and/or monitored. The vector can be used to investigate the effects of RNA interference on a... Agent: Kilyk & Bowersox, P.l.l.c.

20090258352 - Pin1 as a marker for abnormal cell growth: Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment... Agent: Clark & Elbing LLP

20090258345 - Protein associated with colorectal cancer, polynucleotide including single-nucleotide polymorphism associated with colorectal cancer, microarray and diagnostic kit including the same, and method of diagnosing colorectal cancer using the same: Provided are an isolated nucleolar protein having an amino acid sequence of NCBI GenBank Accession No. XP_033371, a method of diagnosing colorectal cancer in an individual, including measuring an expression level of a protein having an amino acid sequence of NCBI GenBank Accession No. XP_033371 in the individual, and a... Agent: Cantor Colburn, LLP

20090258362 - Rna bioassay: The present invention relates to methods for characterizing the pathological state of the kidney, methods of characterizing an agent, methods of evaluating the kidney protective and therapeutic characteristics of an agent and methods of monitoring the effect of a pharmaceutical agent on the kidney of a subject, related to measuring... Agent: Myers Bigel Sibley & Sajovec

20090258363 - Targeted integration and expression of exogenous nucleic acid sequences: Disclosed herein are methods and compositions for targeted integration of a exogenous sequence into a predetermined target site in a genome for use, for example, in protein expression and gene inactivation.... Agent: Robins & Pasternak

20090258361 - Variant tlr4 nucleic acid and uses thereof: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.... Agent: Schwegman, Lundberg & Woessner, P.A.

20090258372 - Detection systems utilizing supported lipid bilayers: The invention relates to lipid bilayer coated beads and methods of using those beads in immunoassays, in analytical assay and the like.... Agent: Gonzales Patent Services

20090258371 - Method of detecting very low levels of analyte within a thin film fluid sample contained in a thin thickness chamber: A method and apparatus for the detection and quantification of very low levels of a target analyte using an imaging system is provided. In the case of some analytes such as certain hormones, for example TSH, their levels may be as low as several tens of thousands of molecules per... Agent: O''shea Getz P.C.

20090258373 - Methods of controlling the sensitivity and dynamic range of a homogeneous assay: A method is disclosed for accurately determining the concentration of a target analyte utilizes reagent pairs having different affinity for the target. The different affinity provides distinct binding profiles that can be analyzed to absolutely determine the analyte concentration. The method provides an assay system having expanded dynamic range to... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090258376 - Protein isoforms and uses thereof: (b) comparing the abundance of said Protein Isoform(s) in the test sample with the abundance of said Protein Isoform(s) in a test sample from one or more persons free from neurological disorder, or with a previously determined reference range for that Protein Isoform in subjects free from neurological disorder, wherein... Agent: Klauber & Jackson

20090258375 - Assays for detecting pregnancy-associated glycoproteins: Disclosed are methods and compositions for detecting pregnancy in an animal by means of assaying peptidase activity of one or more Pregnancy Associated Glycoproteins (PAGs). In certain aspects, methods also comprising use of an antibody that binds immunologically to a PAG that displays proteolytic activity are provided. Substrates of proteolytic... Agent: Sonnenschein Nath & Rosenthal LLP

20090258374 - Multisignal labeling reagents, and processes and uses therefor: The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in detecting or amplifying analyte-specific moieties.... Agent: The Webb Law Firm, P.C.

20090258379 - Isolation of membrane vesicles from biological fluids and methods of using same: Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about... Agent: Stites & Harbison, PLLC

20090258377 - Method of measuring enzymatic activity of adsorbed allergenic enzyme: The invention relates to a method of measuring the immunological activity of a vaccine preparation in the form of a mixture of one or more allergenic enzyme(s) and an oxygen-containing metal salt adjuvant, wherein the mixture comprises a liquid phase and a solid phase, and wherein at least a part... Agent: Birch Stewart Kolasch & Birch

20090258378 - Stress-induced phosphoprotein 1 as a biomarker for the detection of human ovarian cancers and endometriosis: Disclosed herein is a method for the detection, preliminary screening or monitoring of a gynecological disease selected form ovarian cancers and endometriosis, in which STIP1 is used as a biomarker for the gynecological disease.... Agent: Christie, Parker & Hale, LLP

20090258380 - Perhydrolase epitopes: The present invention provides perhydrolase enzyme CD4+ T-cell epitopes, as well as variants that exhibit reduced immunogenic responses, as compared to the parental perhydrolase . The present invention further provides DNA molecules that encode perhydrolase variants, and host cells comprising DNA encoding perhydrolase variants, as well as methods for making... Agent: Jill A. Jacobson Genencor International

20090258381 - Methods for determining the cleavability of substrates: The invention relates to methods for examining the enzymatic cleavability of substrates. In the methods, compounds, which have a cleavability of the section to be examined, are firstly synthesized on a first solid phase, separated therefrom, the cleavage reaction is carried out in solution and the cleaved and uncleaved compounds... Agent: Nixon & Vanderhye, PC

20090258382 - Novel devices for the detection of the presence and/or activity of proteases in biological samples: The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090258383 - Opto-fluidic architecture for particle manipulation and sorting: This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to individual chambers in the device, detection and/or analysis of the particles is carried out, such that a cell or population whose... Agent: Pearl Cohen Zedek Latzer, LLP

20090258384 - Direct antimicrobial susceptibility assay: An antimicrobial susceptibility assay, including the steps of: providing an assay dish; providing a growth medium in said dish; providing an antimicrobial agent sample; providing an interpretive indication located a predetermined distance from a sample location adjacent the growth medium in the assay dish; providing an interfitting element which interfits... Agent: Read R. Taintor

20090258385 - Method of analyzing cells by flow cytometry, use of an antioxidant and/or free radical-scavenging agent in such a method and incubation buffer comprising an antioxidant and/or free radical-scavenging agent: The invention relates to a method of analyzing cells by flow cytometry and the use of an antioxidant and/or free radical-scavenging agent in such a method. It also relates to an incubation buffer comprising an antioxidant and/or free radical-scavenging agent. The method of the invention comprises a step for labeling... Agent: Alston & Bird LLP

20090258386 - Methods for solid mutagenesis and semi-solid fluid mutagenesis fermentation and purification of lipid soluble vitamins and nutrients: According to the invention, Applicants have demonstrated methods for improving industrial biosynthesis of lipid soluble vitamins and nutrients. Applicants have also provided methods for cost-efficient and commercially-viable chemotherapeutic biosynthesis and purification. This invention provides novel methods for both solid mutagenesis and semi-solid fluid mutagenesis fermentation and the purification of lipid... Agent: Nyemaster, Goode, West, Hansell & O'brien, P.C.

20090258387 - Bioactive whey protein hydrolysate: The invention relates to a partial hydrolysate of when protein which contains bioactive peptides but does not have a bitter flavour. The hydrolysate is carried out using selective enzymes which produce the active peptides and is terminated at a degree of hydrolysis before substantial bitter flavours are created. There are... Agent: Knobbe Martens Olson & Bear LLP

20090258389 - Construction of new variants of dextransucrase dsr-s by genetic engineering: The present invention relates to a recombinant process for the production of truncated and/or mutated dextransucrases while conserving their enzymatic activity and/or their specificity in the synthesis of the α-1,6 bonds. More precisely, the present invention relates to nucleic acid sequences of truncated and/or mutated dextransucrases, vectors containing said nucleic... Agent: Kusner & Jaffe Highland Place Suite 310

20090258388 - Methods of enhanced heterologous protein secretion: A method of enhancing heterologous protein secretion in a yeast cell is disclosed. In one embodiment, the method comprising the steps of engineering a yeast cell to overexpress at last one gene selected from the group consisting of CCW12, CWP2, SED1, RPP0, ERO1 and their homologs, supplying the yeast cell... Agent: Quarles & Brady LLP

20090258390 - Prokaryotic collagen-like proteins and uses thereof: The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host... Agent: Benjamin Aaron Adler Adler & Associates

20090258391 - Recombinant cell clones having increased stability and methods of making and using same: Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention... Agent: Baxter Healthcare Corporation

20090258394 - Method for the production of high-level soluble human recombinant interferon alpha in e. coli and vectors useful for such a production: A method for the production of high-level soluble human recombinant interferon alpha protein (rhuIFNα) in E. coli and vectors useful for such a production which comprises: (1) transforming an E. coli selected in the group consisting of E. coli protease deficient host strains, and E. coli reductase deficient host strains,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090258392 - Sequence diversity generation in immunoglobulins: Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations... Agent: Seed Intellectual Property Law Group PLLC

20090258393 - Single chain class i major histocompatibility complexes, constructs encoding same and methods of generating same: Provided are methods of generating a functional mammalian single chain MHC class I complex in prokaryotic expression systems and a host cell transformed with expression construct(s) capable of expressing a functional human single chain MHC class I complex capable of presenting specific antigenic peptides restricted to specific CTL clones.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090258395 - Irx-2 modified manufacturing process: A highly efficient method of making a primary cell derived biologic by purifying mononuclear cells (MNCs) in a automated cell processor to remove contaminating cells by loading leukocytes onto lymphocyte separation medium (LSM) and centrifuging the medium to obtain purified MNCs, storing the MNCs overnight in a closed sterile bag... Agent: Kohn & Associates, PLLC

20090258396 - Crustaceans as production systems for therapeutic proteins: A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus... Agent: Moore & Van Allen PLLC

20090258397 - Method of producing meningococcal meningitis vaccine for neisseria meningitidis serotypes a, c, y, and w-135: Methods for producing quadrivalent meningococcal meningitis polysaccharide and conjugate vaccines for serotypes A, C, Y and W-135 disclosed. Neisseria meningitidis fastidious medium was designed to maximize the yield of capsular polysaccharides and generate minimal cellular biomass and endotoxin in a short duration of fermentation. The crude polysaccharides are isolated, purified,... Agent: Jeeri R. Reddy

20090258399 - Method for production of amino acid: According to the present invention, there are provided a microorganism belonging to Enterobacteriaceae wherein a function of CsrB RNA or CsrC RNA has been decreased or lost, and which has the ability to produce and accumulate an amino acid, and a process wherein the microorganism is cultured in a medium... Agent: Leydig Voit & Mayer, Ltd

20090258398 - Process for the production of beta-amino acids using acylase: The present invention relates to a Variovorax sp. which produces an acylase having an asymmetric hydrolysis activity on an N-acetyl β-amino acid to selectively produce an R-β-amino acid, and a Burkholderia sp. which produces both an acylase having an asymmetric hydrolysis activity on an N-acetyl β-amino acid to selectively produce... Agent: Cermak & Kenealy LLP Acs LLC

20090258401 - L-amino acid producing bacterium and method of producing l-amino acid: L-amino acid is produced by culturing a bacterium belonging to the Enterobacteriaceae family which has L-amino acid-producing ability and is modified so that expression of the nhaA gene, nhaB gene, nhaR gene, chaA gene, mdfA gene, or combinations thereof is enhanced.... Agent: Cermak & Kenealy LLP Acs LLC

20090258400 - Mutant tyrosine repressor, a gene encoding the same, and a method for producing l-dopa: A mutant tyrosine repressor that does not require tyrosine to induce expression of tyrosine phenol-lyase gene is obtained by introducing a mutation into a tyrosine repressor. A microorganism which is able to express large amounts of tyrosine phenol-lyase is obtained by introducing the mutant tyrosine repressor into the microorganism. The... Agent: Cermak & Kenealy LLP Acs LLC

20090258402 - L-glutamic acid producing bacterium and a method for production of l-glutamic acid: A method for producing L-glutamic acid by culturing a coryneform bacterium which has L-glutamic acid producing ability and which has been modified so that expression of the fasR gene is enhanced in a medium to produce and accumulate L-glutamic acid in the medium or cells, and collecting L-glutamic acid from... Agent: Cermak & Kenealy LLP Acs LLC

20090258403 - Novel aldolase, and method for producing optically active ihog and monatin: The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090258404 - Production of fermentation products in biofilm reactors using microorganisms immobilised on sterilised granular sludge: Production of fermentation products, such as ethanol and lactic acid in biofilm reactors by microorganisms immobilised on sterilised granular sludge.... Agent: Roberts Mlotkowski Safran & Cole, P.C. Intellectual Property Department

20090258405 - Preparation of optically active alcohols with whole-cell catalysts: The present invention relates to a process for the preparation of optically active alcohols from ketones with the aid of whole-cell catalysts comprising an alcohol dehydrogenase and also an enzyme capable of cofactor regeneration, a substrate concentration of at least 500 mM of ketone being provided for the conversion and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090258406 - Use of esterases for separating plastics: The invention relates to agents containing esterases, and to the use thereof for dressing fibres, in particular, artificial fibres, washing and cleaning agents comprising esterases and corresponding washing and cleaning methods, in addition to additional technical areas of application. The invention also relates to the use of esterases for protecting... Agent: Connolly Bove Lodge & Hutz LLP

20090258407 - Temperature transfer devices: A portable temperature transfer device for transferring thermo energy to and/or from a laboratory culture plate is provided as well as its methods of use. The temperature transfer device comprises a base and a raised stage that comprises a thermal conductive material. The raised stage allows direct contact between individual... Agent: Don D. Cha

20090258408 - Method for the isolation of spiroplasma in mammals: The present invention is directed to a method of isolating and culturing spiroplasma by obtaining a tissue sample from a bovine; inoculating embryonated eggs with the tissue sample; mixing fluid from the inoculated egg with culture media; culturing the media mixed with the egg fluid at approximately 32° C. for... Agent: Birch Stewart Kolasch & Birch

20090258410 - Methods for producing soluble membrane spanning proteins: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in... Agent: Morrison & Foerster LLP

20090258409 - Purified sr-p70 protein: The invention relates to new nucleic acid sequences of the family of tumor-suppressing genes related to the gene for the p53 protein, and to corresponding protein sequences.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20090258411 - Centrifugal device and method for ova detection: A centrifugal device and method are provided for the separation of buoyant material such as parasitic ova from fecal matter. A rotor assembly, rotatable about its central axis in a centrifuge, includes a housing with a centrally located top opening leading to a centrally located mixing chamber. An annular sediment... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20090258412 - Reactor: Disclosed herein is a reactor, including, a plurality of reaction regions, a plurality of heating elements, each arranged in each of the reaction regions, and cooling elements that cool other regions than reaction regions which are heated by the heating elements, wherein the heating element including a heater and a... Agent: Wolf Greenfield & Sacks, P.C.

20090258413 - Reactor: Disclosed herein is a reactor including, a plurality of reaction regions, and a plurality of heaters, each arranged in each of the reaction regions, wherein the heater including a semiconductor heat generating element and a semiconductor temperature detecting element and being capable of independent temperature control, and the temperature detecting... Agent: Wolf Greenfield & Sacks, P.C.

20090258415 - Fluid manipulation assembly: Microfluidic assemblies, systems, and methods are provided for manipulating fluid samples. Assemblies include an elastically deformable cover layer and a less elastically deformable substrate. The methods include deforming the substrate through the cover layer so that when the cover layer rebounds a new communication results in the assembly between the... Agent: Life Technologies Corporation C/o Intellevate

20090258414 - System for fluorescence monitoring: The present invention is directed to devices for performing PCR and monitoring the reaction of a sample comprising a nucleic acid and a fluorescent dye. Illustrative devices comprise a heat exchange component for heating and cooling the sample, a control device for repeatedly operating the heat exchange component to subject... Agent: Ice Miller LLP

20090258416 - Polymer micelle complex including nucleic acid: It is an object of the present invention to provide a polyion complex used as a non-viral gene vector, which achieves sufficiently high gene expression efficiency to a target cell. The polyion complex of the present invention comprises a block copolymer formed by binding polyethylene glycol to polycation via a... Agent: Darby & Darby P.C.

20090258417 - Culture vessel and a method of culture: A culture vessel comprising a gas permeable film which has oxygen permeability of PO2×S/V>2.0, carbon dioxide permeability of PCO2×S/V>8.0 and water vapor permeability of PH2O×S/V<0.02 where V (ml) is a set capacity, S (cm2) is area of the gas permeable film, PO2 (ml/cm2•day•atm) is oxygen permeability at 37° C., PCO2... Agent: Hedman & Costigan P.C.

20090258418 - Reactive 1,3'-crosslinked carbocyanines and their bioconjugates: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.... Agent: Jeffrey A. Mckinney, J.d., Ph.d.

20090258419 - Method for removing prion protein: The present invention relates to a method for removing prion PrPSc proteins from biological material by contacting a biological material comprising prion PrPSc proteins with sepharose under conditions that allow for the specific and high affinity binding of the sepharose to the prion PrPSc proteins and removing the biological material... Agent: The Nath Law Group

20090258420 - Altered polypeptides, immunoconjugates thereof, and methods related thereto: The present invention features inter alia altered binding polypeptides having engineered cysteine residues or analogs thereof at a predetermined site within, for example, a constant region domain or a portion thereof. The engineered cysteine residues or analogs thereof provide sites for conjugating effector moieties (e.g. diagnostic or therapeutic agents) that... Agent: Lahive & Cockfield, LLP / Biogen Idec Floor 30, Suite 3000

20090258421 - Embryonic stem cells and neural progenitor cells derived therefrom: The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving... Agent: Scully Scott Murphy & Presser, PC

20090258422 - Optically detectable organophosphonates: in which X represents an optically detectable moiety, n is an integer with 1≦n≦20, R1 is an unbranched or branched alkyl group having 1 to 20 carbon atoms, and R2 is hydrogen or —CH2—O—R3 group, wherein R3 has the same meaning as R1. These compounds are useful as inhibitors of... Agent: Birch Stewart Kolasch & Birch

20090258423 - Cell cycle regulation and differentiation: The present invention provides compositions and methods for regulating neural cell proliferation or differentiation. The present invention also provides methods for selecting for bioactive agents effective in regulating proliferation or differentiation.... Agent: Wilson, Sonsini, Goodrich & Rosati

20090258424 - Cellular delivery of sirna: The invention provides a method for delivering a nucleic acid to a cell using a targeting molecule that is bound non-covalently to the nucleic acid. Compositions and kits are also provided.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20090258425 - Gene knock-down by intracellular expression of aptamers: Materials and Methods are provided for target validation by gene knock-down with intracellularly expressed aptamers and siRNAs. The aptamers produced by the materials and methods of the invention are useful in target validation for therapeutics development.... Agent: Mintz, Levin, Cohn, Ferris, Glovskyand Popeo, P.C.

20090253115 - Composition for preserving platelets and method of using the same: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally,... Agent: Morris Manning Martin LLP

20090253117 - Enzymatic substrates for multiple detection systems: An inventive substrate is provided which includes a substrate compound of formula A-B1-B2-B3-B4: wherein A is a sugar moiety; B1 is a linker moiety allowing the conjugation of moiety A and the remaining structure of the substrate; B2 is a linker moiety with a free reactive amino group so as... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20090253118 - Luminescence quenchers and fluorogenic probes for detection of reactive species: Provided herein are compounds or fluorogenic probes which can be used as reagents for measuring, detecting and/or screening ROS or RNS such as peroxynitrite or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of peroxynitrite or hypochlorite in chemical samples and... Agent: Jones Day

20090253116 - Metabolic syndrome evaluating apparatus, method, system, program, and recording medium therefor: According to the method of evaluating metabolic syndrome, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and the state of metabolic syndrome in the subject is evaluated based on the measured amino acid concentration data of... Agent: Foley And Lardner LLP Suite 500

20090253120 - Dna virus detection by dna chip: The disclosure relates to chips containing nucleic acid probes or primers and their use in methods to detect nucleic acid molecules of DNA viruses. The disclosure includes DNA chips in contact with a thermocycler capable of automatically regulating the temperature, temperature cycle times, and number of temperature cycles of the... Agent: Patentique PLLC

20090253123 - Hepatitis b variants with reduced sensitivity to therapeutic compounds, their detection and uses thereof: The present invention is a diagnostic kit and materials for: 1) the prediction of the long-term response of a chronic hepatitis B virus (HBV) carrier to treatment with nucleoside/nucleotide analogue, or their combination; 2) the detection of HBV variants that exhibit reduced reactivity to antibody detection; 3) the detection of... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090253119 - Lateral flow system and assay: The present invention relates to a lateral flow assay and system, including a test strip, for detection and quantification of analytes in samples, such as samples containing cells and fluid. In general, according to the present invention, a test strip for a lateral flow assay for detection of at least... Agent: Global Patent Group - Rla

20090253121 - Method for amt-rflp dna fingerprinting: An improved method for identifying and classifying organisms is provided. The method comprises the steps of obtaining a sample of DNA, isolating a portion of the sample to be analyzed, cutting the sample portion into at least two fragments, ligating both ends of the fragments with double-stranded linker sequences, adding... Agent: Husch Blackwell Sanders LLP

20090253124 - Method for detecting human papillomavirus mrna: An in vitro method is provided for screening human female subjects to assess their risk of developing cervical carcinoma which comprises screening the subject for expression of mRNA transcripts from the E6 and optionally the L1 gene of human papillomavirus, wherein subjects positive for expression of L1 and/or E6 mRNA... Agent: Wolf Greenfield & Sacks, P.C.

20090253122 - Method for measuring resistance of a patient hiv-2 to protease inhibitors: A search method in a biological sample containing an HIV 2 viral strain for possible resistance of said strain to treatment by an anti-protease agent, and nucleotide probes for the implementation thereof. According to methods known per se, the presence of at least one mutation at certain, specified, particular positions... Agent: Oliff & Berridge, PLC

20090253140 - Assay for genetic polymorphisms using scattered light detectable labels: Described are methods for determining the presence or absence of particular polymorphisms in CYP2D6 and other genes using scattered light detectable particles as detectable labels, and compositions useful in such methods.... Agent: Buchanan, Ingersoll & Rooney PC

20090253130 - Bio memory disc and bio memory disc drive apparatus, and assay method using the same: The present invention provides a bio memory disc where a lab-on-a-chip process system including an assay-diagnosis unit, a nucleic acid hybridization assay unit, or an immuno-assay unit and a semiconductor memory is disposed, a bio memory disc drive apparatus including a controller for controlling and driving an optical disc including... Agent: Staas & Halsey LLP

20090253126 - Biomarker detection assays: A method for identifying compounds capable of modulating the Notch pathway. The test compound is either administered to an animal or is brought into contact with a cell in culture, after which the expression of the basic helix-loop-helix transcription factor Math1 in a sample from said animal or cell is... Agent: Astra Zeneca Pharmaceuticals Lp Global Intellectual Property

20090253134 - Cellular pyrogen test: The invention concerns methods, agents and kits for qualitative and quantitative detection and identification of pathogens and pathogen spectra based on endotoxins and other pyrogens.... Agent: BatemanIPLaw Group

20090253142 - Compositions and methods for analysis of nucleic acid molecules during amplification reactions: The present invention provides systems, methods and kits for performing a detection assay (e.g., invasive cleavage assay) in combination with an amplification assay (e.g., PCR), where the detection assay employs enzyme footprint probes with relatively short (e.g., 6-12 bases) analyte-specific regions configured to provide a preferred footprint length of duplex... Agent: Casimir Jones, S.c.

20090253139 - Compositions and methods for glioma classification: The present invention provides novel compositions and their use in classifying gliomas. In a preferred embodiment, the methods are used to discriminate between oligodendroglioma and glioblastoma.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090253127 - Compositions for marking objects with dna and methods for marking and linking an object to its owner: The invention can be summarized as follows. There is provided one or more DNA coating compositions that comprise one or more polymer compounds, water, and optionally one or more non-water polar solvents. The DNA coating composition may also comprise DNA. Also provided are methods and kits for marking objects with... Agent: Suzannah K. Sundby Smith, Gambrell & Russel, LLP

20090253133 - Enhanced t cell receptor-mediated tumor necrosis factor superfamily and chemokine mrna expression in peripheral blood leukocytes in patients with crohn's disease: A method is disclosed for determining whether a human having Crohn's disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohn's disease therapy in... Agent: Knobbe Martens Olson & Bear LLP

20090253143 - Fluorophore compounds: Provided herein are fluorophore compounds including rhodol and rhodamine compounds which can be used as fluorescent labels and/or fluorogenic probes and methods of making same. Provided also herein are methods that can be used to track, measure, detect, or screen biological species such as protein, DNA, enzyme, antibody, organelle, cell,... Agent: Jones Day

20090253136 - Genetic risk assessment technology for epithelial cancer involving gene-environment interaction between ercc5 and tobacco use: Methods and compositions for assessing ERCC5 gene expression in view of certain environmental exposures and determining the risk of an individual for developing one or more epithelial cancers are provided.... Agent: Banner & Witcoff, Ltd.

20090253131 - Hybrid fusion reporter and uses thereof: The invention provides vectors encoding hybrid fusion proteins and vector sets encoding different hybrid fusion proteins useful, for instance, in protein complementation assays.... Agent: Schwegman, Lundberg & Woessner, P.A.

20090253129 - Identification of usa300 community-associated methicillin-resistant staphylococcus aureus: The present invention provides methods for identifying the US A300 strain of methicillin-resistant Staphylococcus aureus (MRSA).... Agent: Mueting, Raasch & Gebhardt, P.A.

20090253138 - Kif20a directed diagnostics for neoplastic disease: Disclosed are methods for diagnosing cancer in a test cell sample or fluid sample by detecting an increase in the level of expression of KIF20A in the test cell sample or fluid sample as compared to the level of expression of KIF20A in a control cell sample or fluid sample... Agent: Wilmerhale/boston

20090253145 - Method for detecting and quantitating multiple subcellular components: A method for detecting and quantitating multiple and unique fluorescent signals from a cell sample is provided. The method combines immunohistochemistry and a fluorescent-labeled in situ hybridization techniques. The method is useful for identifying specific subcellular components of cells such as chromosomes and proteins.... Agent: Kelley Drye & Warren LLP

20090253141 - Methods and apparatuses for analyzing polynucleotide sequences: Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090253144 - Methods of assessing dna damage: This invention relates to the finding that HP1β is phosphorylated at Thr51 at an early stage in the DNA damage response in cells. Thr51P HP1β is therefore a biomarker for DNA damage which may be useful, for example, in assessing DNA damage, cancer susceptibility or the responsiveness of an individual... Agent: Bozicevic, Field & Francis LLP

20090253137 - Methods of screening for risk of proliferative disease and methods for the treatment of proliferative disease: A method of screening a subject for a proliferative disease risk factor comprises detecting the presence or absence of upregulation of the CLN3 gene in the subject. The upregulation of the CLN3 gene in the subject indicates the subject is at increased risk of developing a proliferative disease. Methods of... Agent: Myers Bigel Sibley & Sajovec

20090253132 - Mutated acvr1 for diagnosis and treatment of fibrodyplasia ossificans progressiva (fop): This invention is directed to mutated Activin A type I receptor proteins (ACVR1) and isolated nucleic acids encoding same. The invention also relates to the use of mutated ACVR1 in the diagnosis and treatment of Fibrodysplasia Ossificans Progressiva (FOP).... Agent: Pearl Cohen Zedek Latzer, LLP

20090253128 - Nucleotide sequence for identifying of acinetobacter bacteria, and method and kit of identification of acinetobacter bacteria: Nucleotide primers for identifying Acinetobacter bacteria. The nucleotide primers of the invention are SEQ ID No: 1 to 13, which can be used to effectively and accurately identify various Acinetobacter bacteria. Additionally, the invention further provides a method and kit of identification of Acinetobacter bacteria using the SEQ ID No:... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20090253135 - Polymorphisms of the blys gene and use in diagnostic methods: The present invention provides an isolated polynucleotide comprising at least one polymorphic nucleotide sequence, for example, the major alleles of the SNPs described as rs12583006, rs1224141, and rs1248930 and diagnostic assays for detecting the presence of these polymorphism associated with a condition associated with BLyS activity, such as hematological malignancy... Agent: Fish & Richardson P.C.

20090253147 - Marker for stem cells: Methods and compositions are provided for the identification of stem cells, including neural, muscle and hair follicle stem cells.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090253146 - Methods of expressing integrin beta6 subunits: The present invention provides substantially pure integrins containing a novel β subunit designated as β6. The novel β6 subunit forms heterodimers with αV and αF. Methods of controlling cell adhesion using the β6-containing integrins are also provided.... Agent: Townsend And Townsend And Crew, LLP

20090253148 - Fluorescence polarization herg assay: Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein... Agent: Life Technologies Corporation C/o Intellevate

20090253153 - Methods of using a g protein-coupled receptor to identify peptide yy (pyy) secretagogues and compounds useful in the treatment of conditions modulated by pyy: The present invention relates to methods of using GPR119 receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY, such as conditions modulated by stimulation of NPY Y2 receptor (Y2R). Agonists of GPR119 receptor are useful as therapeutic agents for treating or... Agent: Fish & Richardson P.C.

20090253152 - Novel mutant igfbp-3 molecules that do not bind to igfs, but retain their ability to functionally bind igfbp-3 receptor: There is disclosed novel mutant IGFBP-3 polypeptides and fragments thereof that have either no binding, or diminished binding to IGFs, yet retain their ability to bind to the human IGFBP-3 receptor (“P4.33”). The present invention provides novel mutant IGFBP-3 nucleic acid sequences, and expression systems. Additional exemplary embodiments provide for... Agent: Davis Wright Tremaine, LLP/seattle

20090253151 - Self-renewing master adult pluripotent stem cells: The present invention relates to a method for obtaining master adult pluripotent stem (MAPS) cells from adult human corneal epithelial tissues. The MAPS cells are obtained on the basis of pluripotent markers. Further the invention provides MAPS cells that are capable of self renewal and differentiation and have characteristics similar... Agent: Oliff & Berridge, PLC

20090253149 - Novel chemistry used in biosensors: The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.... Agent: Morgan, Lewis & Bockius, LLP

20090253150 - Three part assay for kinase or phosphatase activity: The present invention relates to a method of determining kinase or phosphatase activity based on a three parts system. The method comprises contacting a binding partner which can bind phosphorylated peptides, a detection molecule and a substrate peptide. Determination of activities is achieved by measuring energy transfer between an energy... Agent: Hoffmann-la Roche Inc. Patent Law Department

20090253154 - Blood and saliva test for detection of delayed food allergy and intolerance against modified foods: A method for determining the presence of delayed food allergy and intolerance against antigens extracted from modified foods. The method includes determining a level of antibodies against a modified dietary food antigen in blood and mucosal samples from the patient and comparing the level with normal levels of the antibodies.... Agent: Cislo & Thomas LLP

20090253155 - Method for diagnosing irritable bowel syndrome and monitoring inflammatory bowel disease: A method for aiding in differentiating irritable bowel syndrome from inflammatory bowel disease by determining the level of total endogenous human lactoferrin in clinical specimens, such as feces, mucus and bile, wherein an elevated level of lactoferrin substantially precludes diagnoses of IBS and other noninflammatory etiologies, and a kit usable... Agent: Shook, Hardy & Bacon LLP Intellectual Property Department

20090253156 - Mass spectrometry methods for multiplexed quantification of protein kinases and phosphatases: The inventions relates to methods and kits for capture and/or analysis of kinases and/or phosphatases in one or more samples. In some embodiments, a kinase inhibitor, e.g. staurosporine or its derivative, is used to capture kinases from a sample. In some embodiments, a phosphatase inhibitor, e.g. microcystin or its derivative,... Agent: Wilmer, Hale, Perkin & Elmer, LLP

20090253157 - Method of directed differentiation of porcine embryonic stem cells and using the said cells in drug screening: The present invention relates to a method of directed differentiation of porcine embryonic stem cells into specific neural lineages. The present invention also relates to a method for identifying neurogenic stimulator using the said porcine embryonic stem cells.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090253158 - Lipoxygenase enzyme assay: A method for identifying inhibitors of a lipoxygenase enzyme, the assay comprising: contacting a lipoxygenase enzyme with a test Compound, a lipoxygenase enzyme Substrate and oxygen; adding a fluorometric reagent and a peroxidase; measuring the fluorescent signal; determining the amount of enzyme inhibition by the test Compound.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20090253161 - Fluorescent prochelators for cellular iron detection: m

20090253159 - Ion channel assay methods: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a... Agent: Knobbe Martens Olson & Bear LLP

20090253162 - Method and apparatus for analyzing skin and hair: The present invention includes compositions, methods, and systems for the analysis of skin and hair conditions. The system includes a method and apparatus for analyzing skin and hair samples by taking a sample, identifying desired components of the sample, obtaining an image electronically, storing the image, and analyzing the image... Agent: Chalker Flores, LLP

20090253160 - Novel method of predicting pig litter size by evaluating semen: e

20090253163 - Iterative staining of biological samples: Automated methods and devices that facilitate iterative staining of biological samples from imaging applications are provided. The methods include the steps of providing a small volume flow cell containing a biological sample, applying a stain to the biological sample, combining at least two precursor reagents to form an activated destaining... Agent: General Electric Company Global Research

20090253164 - E. coli for efficient production of caratenoids: An improved E. coli for carotenoid production comprising exogenous nucleic acids for expressing a carotenoid that the E. coli requires as necessary condition for the E. coli to reproduce. Some E. coli embodiments have diminished or abrogated expression of a gene in the group consisting of ldhA, frdA, poxB, pta,... Agent: Dardi & Associates, PLLC

20090253166 - conjugation of peptides: Methods for the selective conjugation of peptides which comprises an enzymatic incorporation of a functional group at the C-terminal end of a peptide followed by reaction with a second compound comprising the moiety to be conjugated to the peptide, wherein said second compound comprises a functional group which selectively reacts... Agent: Novo Nordisk, Inc. Intellectual Property Department

20090253165 - Method for preparing microcapsules by coacervation: The present invention relates to a method for preparing microcapsules by coacervation, and to the use of transglutaminase for cross-linking in complex coacervation. The present invention relates further to coacervation processes in general in which a material to be encapsulated is added to a solution comprising at least one colloid... Agent: Winston & Strawn LLP Patent Department

20090253176 - Cell lines and methods for producing proteins: The methods of the present invention involve the manipulation and/or propagation of oviduct tumor cells derived from either wild-type or transgenic avians.... Agent: Synageva Biopharma Corp.

20090253174 - Expression of heterologous sequences: The present invention provides compositions and methods for expression of heterologous sequences. The compositions and methods are particularly useful for expressing large quantity of heterologous proteins and nucleic acids of therapeutic, diagnostic and industrial applications.... Agent: Wilson Sonsini Goodrich & Rosati

20090253173 - Filamentous fungi with inactivated protease genes for altered protein production: The invention relates to a filamentous fungal cell (e.g., Aspergillus sp.) comprising at least one inactivated protease gene chosen from apsB, a homolog of apsB, cpsA, a homolog cpsA, and combinations thereof. Nucleic acids and methods for making the inactivated mutant filamentous fungal cells are provided as well as methods... Agent: Steven G. Bacsi Danisco US Inc., Genencor Division

20090253172 - Growth factor homolog zvegf4: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the... Agent: Townsend And Townsend And Crew LLP

20090253177 - Maize cellulose synthases and uses thereof: The invention provides isolated cellulose synthase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering cellulose synthase levels in plants. The invention further provides recombinant expression cassettes, host cells, and transgenic plants comprising said nucleic acids.... Agent: Pioneer Hi-bred International, Inc.

20090253167 - Methanol-responsive promoter, fusion gene comprising promoter and foreign gene connected so that foreign gene can be expressed, vector, transformant, and method of producing protein: A methanol-responsive promoter includes the following regions (1) and (2) in this order in the direction from its 5′- to 3′-terminal (1) a methanol-responsive region that is selected from the group consisting of the following (a), (b) and (c) (a) a polynucleotide consisting of the nucleotide sequence of SEQ ID... Agent: Charles N.j. Ruggiero, Esq. Ohlandt, Greeley, Ruggiero & Perle, L.L.P.

20090253171 - Methods for producing secreted polypeptides having biological activity: The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a... Agent: Novozymes, Inc.

20090253168 - Novel transporter protein: A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912, a novel gene was discovered to encode a protein which is able to transport hydantoin compounds. A recombinant with an excellent ability to... Agent: Cermak & Kenealy LLP Acs LLC

20090253170 - Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same: Novel plant derived regulatory sequences and constructs and methods of using such sequences for directing expression of exogenous polynucleotide sequences in trichomes are provided.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090253178 - Recombinant cell clones having increased stability and methods of making and using the same: Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention... Agent: Baxter Healthcare Corporation

20090253175 - Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof: Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active... Agent: K&l Gates LLP

20090253169 - Use of genetically modified organisms to generate biomass degrading enzymes: The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga... Agent: Quine Intellectual Property Law Group, P.C.

20090253179 - Mammalian cell lines for increasing longevity and protein yield from a cell culture: Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene,... Agent: Immunomedics, Inc.

20090253180 - Diagnosis of liver pathology through assessment of anti-gal igg glycosylation: Methods for diagnosing pathology of the liver in subject suspected of having such pathology by measuring the glycosylation of anti-gal IgG in various biological fluids of the subject.... Agent: Woodcock Washburn LLP

20090253182 - Fed-batch fermentation process and culture medium for the production of plasmid dna in e. coli on a manufacturing scale: A process for producing plasmid DNA E. coli cells comprises a pre-culture and fed-batch process. The culture media of the batch phase and the culture medium added during the feeding phase are chemically defined. The culture medium of the feeding phase contains a growth-limiting substrate and is added, for at... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20090253181 - Universal sample preparation system and use in an integrated analysis system: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.... Agent: Wilson Sonsini Goodrich & Rosati

20090253183 - Amplicon rescue multiplex polymerase chain reaction for amplification of multiple targets: Disclosed is a method for amplifying and detecting polynucleotides which can provide sensitive, specific detection of multiple targets from a clinical specimen within a relatively short time.... Agent: Donna J. Russell

20090253184 - Compositions and methods related to an adenoviral trans-complementing cell line: Embodiments of the invention include E1 expressing cell lines that can be used in a variety of methods for production of an E1 defective adenovirus. In certain aspects a cell of the invention can be adapted to various culture conditions, e.g., suspension culture in serum free medium. In a further... Agent: Fulbright & Jaworski L.L.P.

20090253185 - Avipox recombinants expressing foot and mouth disease virus genes: The present invention relates to modified poxyiral vectors and to methods of making and using the same. In particular, the invention relates to recombinant avipox that expresses gene products of foot and mouth disease virus (FMDV), and to compositions or vaccines that elicit immune responses directed to FMDV gene products... Agent: Frommer Lawrence & Haug

20090253125 - Denaturat stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof: Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids encoding SPs; antibodies recognizing SPs; the use of SPs for stabilizing, refolding, repairing, preventing aggregation and de-aggregating... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090253186 - Microorganism producing l-methionine precursor and the method of producing l-methionine precursor using the microorganism: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.... Agent: Lucas & Mercanti, LLP

20090253187 - Microorganism producing l-methionine precursor and the method of producing l-methionine precursor using the microorganism: The present invention relates to a microorganism producing L-methionine precursor, O-succinylhomoserine, and a method of producing L-methionine precursor using the microorganism,... Agent: Lucas & Mercanti, LLP

20090253188 - Delta-4 desaturase and its use in making polyunsaturated fatty acids: Described here are Δ4 desaturases that convert all-cis-7,10,13,16,19-docosapentaenoic acid [“DPA”; 22:5 ω-3] to docosahexaenoic acid [“DHA”; 22:6 ω-3], with secondary activity in converting docosatetraenoic acid [“DTA”; 22:4 ω-6] to all-cis-4,7,10,13,16-docosapentaenoic acid [“DPAn-6”; 22:5 ω-6]. Also, described here are isolated nuclei acid fragments and recombinant constructs comprising such fragments encoding Δ4... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090253189 - Lactic acid-producing yeast cells having nonfunctional l- or d-lactate:ferricytochrome c oxidoreductase cells: Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced I, or D-lactate:ferricytochrome c oxidoreductase... Agent: Gary C. Cohn, PLLC

20090253190 - Enhanced metabolite generation: The present invention relates to the enhanced production of metabolites by a process whereby a carbon source is oxidized with a fermentative microbe in a compartment having a portal. An electron acceptor is added to the compartment to assist the microbe in the removal of excess electrons. The electron acceptor... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20090253191 - Use of rhizopus amylases in granular starch hydrolysis: Described are compositions and methods relating to granular starch hydrolysis. Exemplary used for the compositions and methods are for ethanol production.... Agent: Danisco US Inc. Attention: Legal Department

20090253192 - Process for the biological production of 1,3-propanediol with high titer: The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanediol is achieved by the use of an E. coli transformed with... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090253193 - Apparatus and method for evaluating ex vivo tissue samples by electrical impedance: A device for characterizing ex vivo tissue employs a set of independent electrodes that may be used to scan the tissue by moving a voltage gradient across the tissue surface acquiring impedance spectrographs that may be mapped to an image.... Agent: Boyle Fredrickson S.c.

20090253194 - Dna analysis apparatus: Accurate and sensitive sequencing in pyrosequencing is achieved by allowing complementary strand synthesis reaction to proceed homogeneously and completely in a short time while performing luminescence reaction for a sufficiently long time. DNA as a sequencing target is immobilized on the surface of a solid supporter. Nucleic acid substrates are... Agent: Mattingly & Malur, P.C.

20090253196 - Fluid handling unit and fluid handling apparatus using same: A fluid handling unit 16 has an inside cylindrical portion 16c which is arranged in an outside small-diameter cylindrical portion 16b so as to be eccentric with respect to the outside small-diameter cylindrical portion 16b, and a plurality of slits 16d for establishing a communication between an inside fluid housing... Agent: Bachman & Lapointe, P.C.

20090253195 - Plate platform with visual indicator: A plate platform having a visual indicator that allows the user to track his or her progress in loading the platform wells is generally disclosed. The plate platform is constructed from a substantially transparent base having a plurality of elongated bore-holes internally from the side surface in the substantially transparent... Agent: Dority & Manning, P.A.

20090253197 - Culture plate comprising a lid for lateral ventilation: The present invention pertains to a culture plate, and in particular to a culture plate comprising a lid wherein the peripheral side wall of the lid is formed at least partially of at least one filter element made of a filter material. This enables lateral, uniform ventilation of the culture... Agent: Knobbe Martens Olson & Bear LLP

20090253198 - Cell culture dish: The present invention relates to a to a cell culture dish and particularly to a Petri dish. In the present cell culture dish the wall portion of the base and the top portion of the cover are both provided with markings enabling the correlation of particular cell growth areas to... Agent: Knobbe Martens Olson & Bear LLP

20090253199 - Card member for receiving a tissue specimen to be processed for histological examination: The present invention is directed to a card member for receiving a tissue specimen to be processed for histological examination including an absorbent portion for maintaining the tissue specimen in engageable contact with the card member, and a generally non-adhesive portion for allowing separation of the tissue specimen from the... Agent: Thompson Coburn LLP

20090253200 - Cadherin-11 antagonists and methods for the treatment of inflammatory joint disorders: The present invention relates to Cadherin-11 antagonists and compositions comprising Cadherin-11 antagonists. The invention also relates to methods for treating inflammatory joint disorders, such as rheumatoid arthritis, in a mammalian subject by administering a therapeutically effective amount of a Cadherin-11 antagonist.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090253201 - Embryonic stem cells capable of differentiating into desired cell lines: An embryonic stem cell which may be induced to differentiate homogeneously into a desired primary cell line. The embryonic stem cell may be engineered with DNA, which encodes a protein or polypeptide which promotes differentiation of the stem cell into a specific cell line, such as, for example, a neuronal... Agent: Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein

20090253202 - Definitive endoderm: Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.... Agent: Knobbe Martens Olson & Bear LLP

20090253203 - Reprogramming a cell by inducing a pluripotent gene through use of a small molecule modulator: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises exposing a cell to... Agent: Whyte Hirschboeck Dudek S.c. Intellectual Property Department

20090253204 - Continuous flow chamber device for separation, concentration, and/or purification of cells: The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive... Agent: Blank Rome LLP

20090253205 - Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.... Agent: Traskbritt / Battelle Energy Alliance, LLC

20090253207 - Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells: A gene delivery vehicle having been provided with at least a tissue tropism for cells selected from the group of smooth muscle cells, endothelial cells, and/or liver cells. The tissue tropism is generally provided by a virus capsid, such as one comprising protein fragments from at least two different viruses,... Agent: Traskbritt, P.C.

20090253206 - Nuclear transport agent and method for producing said agent: The present invention relates to a transport agent for transporting nucleic acids into eukaryotic cells and a method for producing said agent. The invention further concerns methods for transporting nucleic acids into eukaryotic cells using the transport agent according to the invention. The present invention provides an alternative transport agent... Agent: Joyce Von Natzmer Pequignot + Myers LLC

20090253208 - Recombinant viral vector for gene transfer into lymphoid cells: A recombinant herpesvirus, a method for producing the recombinant herpesvirus, and a pharmaceutical composition comprising the recombinant herpesvirus, are provided with a method for producing a recombinant herpesvirus using a BAC vector sequence. In addition, a vector comprising a herpesvirus genomic gene and a BAC vector sequence, a cell comprising... Agent: King & Spalding LLP