Chemistry: molecular biology and microbiology inventions

20080102439 - Biological tissue for surgical implantation: A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 alcohol and removing a portion of the treatment solution from the solution-treated... Agent: Edwards Lifesciences Corporation

20080102438 - Novel technique to fabricate molded structures having a patterned porosity: The present invention relates to a process for fabricating molded structures having a radially organized pore structure. The molded structures are formed using a spinning-induced sedimentation technique such that sedimentation of a multi-component liquid suspension produces the internal geometry and porosity of the structure. The porous molded structures of the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080102441 - Analyte sensors and methods: Methods of determining analyte concentration. The methods use a fraction of the predicted total charge, from analyte electrolysis, instead of using time, for determination of a data collection endpoint. The total charge is then extrapolated from the data collection endpoint. The analyte concentration is determined from the total charge.... Agent: Merchant & Gould PC

20080102440 - Biological sensor: A biological sensor, especially a barosensor, which can be operated using a neuronal network is described. Neuronal cultures suitable for use in such a sensor are also described.... Agent: Nixon & Vanderhye, PC

20080102443 - Column cartridge, column cartridges assembly, analyzer, and analyzing method: The present invention is to present a column cartridge that enables the obtainment of a plurality of analysis objects from a single sample easily. The column cartridge comprises: a first liquid sample receiving part having an opening for receiving a liquid sample; a carrier for isolating a target substance from... Agent: Sughrue Mion, PLLC

20080102442 - Food sample collector: The present invention provides novel methods and devices for detection of pathogens or other microbes in an analyzed sample (e.g., food, industrial, pharmaceutical, botanical, environmental etc., sample). The inventive methods and devices provide for increasing the power of detection for pathogens on food surfaces, comprising increasing the number of independent,... Agent: Davis Wright Tremaine, LLP/seattle

20080102451 - Companion diagnostic assays for endothelin receptor antagonists: Methods for identifying cancer patients eligible to receive endothelin receptor antagonist therapy and for monitoring patient response to endothelin receptor antagonist therapy comprise assessment of the expression levels of at least one of PAI-1, uPA, TGFbeta2, IL-6, IL-8 and OPG in a patient tissue sample. The methods of the invention... Agent: Vysis, Inc Patent Department

20080102456 - Compositions and methods for obesity screening using polymorphisms in npy2r: Methods and constructs are provided that are predictive of a subject's susceptibility to developing a metabolic disorder, such as obesity. The disclosed naturally-occurring SNPs located upstream of the NPY2R gene can be used as targets for the design of diagnostic reagents and the development of therapeutic agents, as well as... Agent: Nutter Mcclennen & Fish LLP

20080102452 - Control nucleic acid constructs for use in analysis of methylation status: In some embodiments, control nucleic acid constructs useful as spiking reagents are provided which comprise a nucleic acid vector having an insert comprising a control nucleic acid molecule. In some embodiments, the insert contains at least one methyltransferase recognition site, such as a CpG dinucleotide. In some embodiments, the insert... Agent: Agilent Technologies Inc.

20080102450 - Detecting dna methylation patterns in genomic dna using bisulfite-catalyzed transamination of cpgs: Methods and compositions for identifying or detecting methylation patterns in a target nucleic acid are described. Cytosine residues in regions of interest are transaminated and labeled. The labeled residues are then hybridized to a microarray containing probes complementary to the region of interest, to identify the amount of methylation in... Agent: Agilent Technologies Inc.

20080102461 - Device and method for multiple analyte detection: The invention is directed to a method and device for simultaneously testing a sample for the presence, presence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, device for detecting or quantitating a plurality of different analytes in a liquid sample.... Agent: Kilyk & Bowersox, P.l.l.c.

20080102462 - Device and method for multiple analyte detection: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid... Agent: Kilyk & Bowersox, P.l.l.c.

20080102455 - Method of detecting aneuploidy: The present invention provides a method for detecting aneuploidy in a subject. This method has applications for the detection of aneuploidy in single cells, embryos and complete organisms. The present invention has particular application for the detection of aneuploidy in human and other animal embryos generated by in-vitro fertilization. Pre-implantation... Agent: Knobbe Martens Olson & Bear LLP

20080102459 - Method of screening antiobesity agents: The present invention relates to a method of screening for an antiobesity agent, an antidiabetic agent, and/or a hypolipidemic agent, comprising the step of analyzing whether or not a substance to be tested promotes an expression and/or a function of an angiopoietin-related growth factor. The present invention relates to a... Agent: Sughrue Mion, PLLC

20080102449 - Methods and compositions for detecting and identifying species of candida: Methods and compositions useful in the detection and identification of species of Candida are disclosed. These species include Candida albicans, Candida glabrata, Candida parapsilosis, and Candida tropicalis, each of which is a causative agent for vaginal candidiasis. The compositions of the invention are combinations of oligonucleotides. These oligonucleotides include pairs... Agent: Medical Diagnostic Laboratories LLC

20080102453 - Methods and systems and analysis of cgh data: Methods, systems and computer readable media for analysis of comparative genomic hybridization data analysis, including creating a centralization curve from log ratio data values for DNA copy numbers of a genome of a test sample relative to a genome of a reference sample, wherein the reference sample has a known... Agent: Agilent Technologies Inc.

20080102448 - Novel vector and utilization of the same: A vector characterized by having two restriction recognition sequences different in nucleotide sequence both of which are recognized by a first restriction enzyme, one of the restriction recognition sequences comprising a part of a restriction recognition sequence recognized by a second restriction enzyme that is different from the first restriction... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080102458 - Polymorphic loci that differentiate escherichia coli 0157:h7 from other strains: The present invention relates generally to the field of microbiology and food sciences. More particularly, the inventor has discovered several polynucleotide sequences encoding the gnd gene and corresponding 6-phosphogluconate dehydrogenase (6-PGD) proteins from different strains of Escherichia Coli and polymorphic sequences therein. Novel biotechnological tools, diagnostics, and food screening techniques... Agent: Seed Intellectual Property Law Group PLLC

20080102454 - Reducing size of analytes in rna sample: The invention relates to methods for treating samples of RNA. In an embodiment the method includes contacting the sample of RNA with a set of oligodeoxynucleotides to provide a DNA/RNA duplex. The method includes contacting the DNA/RNA duplex with an enzyme having a DNA:RNA nuclease activity to provide a digested... Agent: Agilent Technologies Inc.

20080102460 - System and method for quantifying the sequence specificity of nucleotide binding factors: Systems and methods for determining free energy parameters for predicting binding affinities of nucleotide sequences are provided. The disclosed subject matter obtains phenotypic measurements for nucleotide sequences (for example a DNA sequence or RNA sequence), links the phenotypic measurements to the nucleotide sequences to obtain linked pairs of phenotypic measurements... Agent: Baker Botts L.L.P.

20080102469 - System for analysis of gene sequence: A conventional large-scale parallel pyrosequencing apparatus has the disadvantage that throughput decreases because much time and a large number of procedures are required for introduction of measurement beads, and analysis accuracy is deteriorated due to a reduction in accuracy of reagent replacement. There is provided an apparatus, wherein the apparatus... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080102457 - Target protein and target gene in drug designing and screening method: The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. To be specific, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating... Agent: Leydig Voit & Mayer, Ltd

20080102474 - Detection of a therapeutic antibody in an experimental animal: The present invention relates to the field of therapeutic antibodies. It especially relates to the study of therapeutic antibodies in an experimental animal. The present invention discloses a method of detecting a therapeutic antibody in a sample obtained from an experimental animal comprising the steps of a) providing the sample... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080102473 - Method and system to improve contrast in lateral flow assay: A lateral flow assay includes one or more optically-reactive test regions that are examined using light propagating at a wavelength that matches or nearly matches an absorption wavelength associated with each optically-reactive test region. The presence or absence of a color or absorption in each optically-reactive test region may be... Agent: Kathy Manke Avago Technologies Limited

20080102476 - Analyzing histamine h4 receptor-mediated effects in whole blood: Assay methods for analyzing whole blood to detect histamine H4 receptor-mediated effects, such as eosinophil shape change, cytoskeletal change, adhesion molecule up-regulation, or calcium flux are described. Such methods are useful in clinical and diagnostic applications.... Agent: Philip S. Johnson Johnson & Johnson

20080102477 - Method for screening an anticancer drug using acetylated bubr1: A method of screening for an anticancer drug comprising treating a cancer cell with candidate compounds and assessing the change in acetylated BubR1 level of the cancer cell is useful for efficiently screening an anticancer drug. An antibody which specifically binds to the 250th amino acid residue, Lys, of BubR1... Agent: Sughrue Mion, PLLC

20080102481 - Assay for cardiac troponin autoantibodies: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among... Agent: Paul D. Yasger Abbott Laboratories

20080102480 - Method and apparatus of enzyme-link immunosorbent assay: An improved method of enzyme-link immunosorbent assay (ELISA) is disclosed, which can be adapted to be implemented by an analytic apparatus having a testing platform and a conducting platform, being arranged separate from the testing platform, and comprises steps of: applying a specific agent upon a reaction zone of the... Agent: Wpat, PC

20080102482 - Apparatus for detecting drugs in a beverage: A test kit for detecting the presence of one or more drugs in a beverage comprising a support having a plurality of detector strips attached thereto. Drugs to be detected are e.g. benzodiazepines, gamma hydroxy butyrate GHB), Ketamines, Ectasy (MDMA), cocaine barbiturates, opiates, cannabis and flunitrazepam (Rohypnol®).... Agent: Sonnenschein Nath & Rosenthal LLP

20080102487 - Method and apparatus for non-invasive rapid fungal specie (mold) identification having hyperspectral imagery: In a method and apparatus for identifying and distinguishing fungal species, a hyperspectral imaging scanner is used to acquire hyperspectral image data for radiation obtained from a sample area in which at least one unknown fungal species is present. A computer compares the acquired hyperspectral image data with spectral signature... Agent: Crowell & Moring LLP Intellectual Property Group

20080102486 - Method for detection of yeast cell wall: Methods are provided for detecting the presence of a yeast cell wall in a food or animal feed suspected of containing the yeast cell wall. The method includes the steps of solubilizing the yeast cell wall, adding a lectin which preferentially binds to a mannose component of the solubilized yeast... Agent: King & Schickli, PLLC

20080102485 - Methods and systems for ensuring the security of grain stores: Aspects include claims, systems, and methods for testing bulk grain stores to identify the presence of contaminants. Such contaminants tested for may include biological, chemical, or radio nuclear material. Another aspect is marking and/or tracking grain stores that have been certified as either being contaminated or safe. Still another aspect... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20080102488 - Microorganism of enterobacteriacae genus haboring genes associated with l-carnitine biosynthesis and method of producing l-carnitine using the microorganism: Provided is a microorganism belonging to the family Enterobacteriaceae including: a polynucleotide encoding N-trimethyllysine hydroxylase activity derived from Neurospora crassa; a polynucelotide encoding 3-hydroxy-6-N-trimethyllysine aldolase activity derived from Neurospora crassa; a polynucleotide encoding γ-trimethylaminoaldehyde dehydrogenase activity derived from Neurospora crassa; and a polynucleotide encoding γ-butyrobetaine hydroxylase activity derived from Neurospora... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080102493 - Isolation of rna and dna from a biological sample: The invention relates to methods of isolating nucleic acids from a sample using a filter device comprising a plurality of membranes. The invention also provides for devices comprising a plurality of membranes and kits suitable for isolating nucleic acids from a sample.... Agent: Millipore Corporation

20080102494 - Dna amplification method: It is intended to provide a DNA amplification method whereby a single-stranded DNA in a desired direction and in a desired region can be conveniently and efficiently prepared. Namely, a DNA amplification method with the use of a DNA as a template which comprises: the first step wherein use is... Agent: Wood, Herron & Evans, LLP

20080102495 - Multi-stage amplification reactions by control of sequence replication times: The present invention provides methods and kits for conducting multiplex nucleic acid amplification reactions by controlling target sequence replication times. In one aspect, such control is exerted by selecting different lengths of target polynucleotides for amplification. In another aspect, control is exerted by providing sequence-specific polymerase inhibitors, such as specific... Agent: Townsend And Townsend And Crew, LLP

20080102496 - Expression of nitrile hydratases in a two-vector expression system: The present invention relates to a novel system for expressing nitrile hydratase. In this system, the nitrile hydratases, which are composed of subunits, are formed such that the respective subunits are located on different plasmids and are expressed simultaneously in E. coli.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20080102444 - Methods and compositions for detecting rhinoviruses: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of human rhinovirus (HRV) in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved 5′ untranslated region of the HRV genome. The... Agent: Foley & Lardner LLP

20080102447 - Methods for diagnosing chronic fatigue syndrome: Methods are provided for detecting enteroviral antigens in the stomach of patients having symptoms consistent with chronic fatigue syndrome (CFS). The presence of enteroviral viral antigens in the stomach of these patients is then correlated with the patients' symptoms to establish a diagnosis of CFS.... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20080102445 - Nucleic acid amplification controls: The present invention discloses positive control material for nucleic acid amplification based detection of microorganisms in biological samples. The control material comprises purified microorganism that is rendered non-infectious but is amenable to nucleic acid amplification. Also disclosed is a process for making and using the control material.... Agent: Hodgson Russ LLP The Guaranty Building

20080102446 - Nucleic acid amplification controls: The present invention discloses positive control material for nucleic acid amplification based detection of microorganisms in biological samples. The control material comprises purified microorganism that is rendered non-infectious but is amenable to nucleic acid amplification. Also disclosed is a process for making and using the control material.... Agent: Hodgson Russ LLP The Guaranty Building

20080102468 - Compositions and methods for treatment of non-hodgkin's lymphoma: The present invention is directed to compositions of matter useful for the treatment of non-Hodgkin's lymphoma in mammals and to methods of using those compositions for the same.... Agent: Genentech, Inc.

20080102463 - Gene 4: A nucleotide acid sequence is provided encoding a protein having NAALAdase like activity. NALADase activity has been found to be decreased in schizophrenic brain tissue. Its encoded protein can be used to screen for glutamate peptidase modulators.... Agent: Organon Usa, Inc. Patent Department

20080102464 - Method and device to probe a membrane by applying an in-plane electric field: The present invention disposes a membrane, for example, a biological cell membrane including amphiphilic lipids, cholesterol and proteins, between two electrical conductive walls having a height at least as great as the thickness of the membrane. The conductive walls are fabricated on an electrically insulative chip base. Electrical conductors extend... Agent: Pearne & Gordon LLP

20080102466 - Method of generating nested sets of double stranded dna circles: The invention provides a method of generating nested sets of double stranded DNA (dsDNA) circles that may be used as size ladders in nucleic acid separations and as templates in DNA sequencing operations. In one aspect, the invention provides methods for generating nested sets of double stranded DNA circles in... Agent: Stephen C. Macevicz

20080102470 - Methods and substances for isolation and detection of small polynucleotides: A capture probe suitable for use with methods for isolating, labeling or detecting small polynucleotides. A method for isolating a small polynucleotide of interest from a sample comprising hybridizing the small polynucleotide to the capture probe and lengthening the small polynucleotide by primer extension or ligation. A method for detecting... Agent: Sheldon Mak Rose & Anderson PC

20080102467 - Methods to identify patients at risk of developing adverse events during treatment with antidepressant medication: The invention provides a method of screening patients to identify those patients more likely to exhibit an increased risk of treatment-emergent suicidal ideation comprising: (a) obtaining a sample of genetic material from the patients, and (b) assaying the sample for the presence of a genotype in the patients which is... Agent: Leydig, Voit & Mayer, Ltd.

20080102472 - Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same: Oncokinase fusion polypeptides associated with hyperproliferative disorders and the polynucleotides encoding for such fusion polypeptides are provided. The fusion polypeptides have a C-terminal tyrosine kinase domain fused to an N-terminal domain that is not normally fused to the C-terminal tyrosine kinase domain and they possess constitutively activated tyrosine kinase activity.... Agent: Theravance, Inc.

20080102471 - Plant myb transcription factor homologs: This invention relates to an isolated nucleic acid fragment encoding a Myb-related transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the Myb-related transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080102465 - Pthrp-based prediction and diagnosis of bone disease: The invention provides methods of diagnosing bone disease and/or a susceptibility thereto, in an individual. The method includes screening a biological sample obtained from the individual for one or more genetic indicators of bone disease in said PTHrP gene of the individual, and diagnosing the individual based on a characterization... Agent: Ogilvy Renault LLP

20080102475 - Alternatively spliced isoform of phosphodiesterase 4b (pde4b): The present invention features nucleic acids and polypeptides encoding novel splice variant isoform of phosphodiesterase 4B (PDE4B). The polynucleotide sequence of PDE4Bsv1 is provided by SEQ ID NO: 3. The amino acid sequence of PDE4Bsv1 is provided by SEQ ID NO: 4. The present invention also provides methods for using... Agent: R. Douglas Bradley Merck & Co., Inc.

20080102478 - 3d micro-scale engineered tissue model systems: A polymeric chip having at least one three-dimensional porous scaffold, a microfluidic channel inlet to the porous scaffold, and a microfluidic channel outlet from the porous scaffold. In one embodiment, the polymeric chip has two three-dimensional porous scaffolds: one scaffold comprises liver cells and the other scaffold comprises cancer cells.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080102479 - Method of diagnosing lawsonia intracellularis: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20080102483 - Device and direct method for detection of antibiotic-inactivating enzymes: A method for determining whether a microorganism produces an AmpC β-lactamase is disclosed in which a culture of a microorganism suspected of producing a β-lactamase that inactivates a β-lactam-containing antibiotic is admixed with an effective amount of each of i) a β-lactam-containing antibiotic, ii) a β-lactamase inhibitor to which AmpC... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20080102484 - Dendritic cell transmembrane serine protease: Isolated Dendritic Cell Transmembrane Serine Proteases (DCTSPs), DNAs encoding such DCTSPs, and pharmaceutical and/or diagnostic compositions made therefrom, are disclosed. The isolated DCTSPs can be used to hydrolyze peptide bonds. The DCTSPs are also useful in screening for inhibitors or agonists thereof.... Agent: Immunex Corporation Law Department

20080102491 - Bacterial host cell for the direct expression of peptides: Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth... Agent: Ostrolenk Faber Gerb & Soffen

20080102489 - Dna molecules encoding ligand gated ion channels from dermacentor variabilis: The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding D. variabilis LGIC/GluCl channels, substantially purified forms of associated D. variabilis channel... Agent: Judy Jarecki-black, Ph.d., J.d. Merial Ltd.

20080102490 - Interferon-like protein zcyto21: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.... Agent: Zymogenetics, Inc. Intellectual Property Department

20080102492 - Methods and compositions for the prevention and treatment of anemia: Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a... Agent: Amgen Inc.

20080102497 - Enzymatic hydrolysis of starch: Provided herein are methods of increasing the enzymatic rate of hydrolysis of starch substrates. In certain embodiments the method comprises contacting a starch substrate with one or more amylase family enzymes in the presence of greater than 0.001 mM manganese ions. In certain embodiments, the method comprises contacting a starch... Agent: Calfee Halter & Griswold, LLP

20080102498 - Methods for the separation of streptococcus pneumoniae type 3 polysaccharides: The present invention provides improved methods for the reduction or removal of protein impurities from a complex cellular Streptococcus pneumoniae lysate or centrate comprising serotype 3 polysaccharides involving steps relating to post-lysis heating or pH adjustment. In certain methods, the lysate is heated for a time and at a temperature... Agent: Alston & Bird LLP

20080102499 - Method of enhancing l-tyrosine production in recombinant bacteria: Tyrosine production in a tyrosine over-producing enteric bacterial strain was enhanced by expression of a tyrosine insensitive prephenate dehydrogenase. The prephenate dehydrogenase expressed was the cyclohexadienyl dehydrogenase encoded by the Zymomonas mobilis tyrc gene.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080102500 - Lipase powder compositions: The present invention provides a lipase powder composition which comprises a filter aid(s) and a product obtained by pulverizing a Thermomyces sp.-derived lipase immobilized to a silica carrier(s) into the average particle diameter of 1 μm or more and less than 300 μm. This lipase powder composition improves the lipase... Agent: Buchanan, Ingersoll & Rooney PC

20080102501 - Method of production of optically active halohydrocarbons and alcohols using hydrolytic dehalogenation catalysed by haloalkane dehalogenases: A method of production of optically active compounds, particularly halohydrocarbons, haloalcohols, alcohols, halopolyols and polyols using hydrolytic dehalogenation of racemic or prochiral halegenhydrocarbons by dehalohenation catalysed by haloalkane dehalogenases (the enzyme code number EC 3.8.1.5) where at least one wild type or modified haloalkane dehalogenase is applied to at least... Agent: Notaro And Michalos

20080102502 - Inorganic salt recovery during processing of lignocellulosic feedstocks: A method for recovering inorganic salt during processing of a lignocellulosic feedstock is provided. The method comprises pretreating the lignocellulosic feedstock by adding an acid or a base to the feedstock to produce a pretreated lignocellulosic feedstock. A soluble base or acid is then added to the pretreated lignocellulosic feedstock... Agent: Fitzpatrick Cella Harper & Scinto

20080102503 - Systems and processes for cellulosic ethanol production: A cellulosic ethanol production process. Implementations may include providing a raw cellulose stream by mixing a waste cellulose feed and an algae cellulose feed and hydrolyzing the raw cellulose stream to form a hydrolyzed cellulose stream by reacting the raw cellulose stream with one or more fungi from the phylum... Agent: Booth Udall, PLC

20080102504 - Methods and apparatus for characterizing polynucleotides: Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase, adjacent the nanopore aperture.... Agent: Clark & Elbing LLP

20080102505 - Method of treating viral infections with ultraviolet light: A method of treating a viral infection by stimulating cell mediated immunity in a subject. Specifically, the instant method is performed by applying ultraviolet light to stimulating the subject's immune system to activate potent cell mediate immune responses, including inducing gene expression of various cytokines, against the specific viruses such... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20080102506 - Method for obtaining mesenchymal stem cells: The invention relates to the field of cell biology. In detail it relates to the obtainment of mesenchymal stem cells from human tissue. This invention might be applicable in healing within the frame of the treatment of several diseases. Due to the invention it will be possible to obtain mesenchymal... Agent: Klarquist Sparkman, LLP

20080102507 - Avian embryo particulate biomass for the production of virus antigens: The present invention provides a biomass which comprises avian embryonic particles having a particle size of about 0.5 mm to 10.0 mm and the use thereof in a method for the production of virus antigens. Also provided is a method for the preparation of a vaccine useful for the amelioration... Agent: Wyeth Patent Law Group

20080102508 - Formulation of adenovirus for gene therapy: The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired properties that allow both lyophilized and liquid adenovirus formulations to be stored at 4°... Agent: Fulbright & Jaworski L.L.P.

20080102509 - Bacterial host cell for the direct expression of peptides: Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth... Agent: Ostrolenk Faber Gerb & Soffen

20080102510 - Bacterial host cell for the direct expression of peptides: Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth... Agent: Ostrolenk Faber Gerb & Soffen

20080102511 - Process for the joint culture of an association of microorganism, using pyrite (fes2) as and energy source: The invention publishes a process for the joint culture of an association of microorganisms using pyrite (FeS2) as an energy source. This invention particularly publishes the use of a pyrite ore as an energy source in the joint culture of an association of Acidithiobacillus ferrooxidans and Acidithiobacillus thiooxidans type isolated... Agent: Merchant & Gould PC

20080102512 - Culture method of antrodia camphorata: A culture method of a fruiting body of Antrodia camphorata is provided, which includes: (a) fermenting a culture medium containing yeast at 5-35° C. for 3-30 days; (b) adding wood flour to the fermented culture medium with stirring; (c) placing the wood flour and the culture medium into a vessel;... Agent: Bacon & Thomas, PLLC

20080102513 - Methods and mediums for cultivating dinophysis acuminata: Disclosed are a method and a medium for cultivating the marine dinoflagellate Dinophysis acuminata. The laboratory culture of D. acuminata causing diarrhetic shellfish poisoning, whose cultivation was known difficult, has been first established, thereby contributing to a better understanding of ecophysiology, biology and toxicology of Dinophysis species, as well as... Agent: Jhk Law

20080102514 - Reactor for the culture, biooxidation of solutions and/or large-scale propagation of isolated microorganisms and/or native microorganisms that are useful in ore leaching: The invention publishes a reactor and method for the culture, biooxidation of cations in solution and/or large-scale propagation of jointly isolated microorganisms, with or without native microorganisms that are useful in sulfide metal ore bioleaching. The invention particularly publishes a reactor for the large-scale culture and/or propagation of an association... Agent: Merchant & Gould PC

20080102515 - Use of mining waste and concentrates containing pyrite, in the culture of iron-oxidizing and sulfur-oxidizing microorganisms as an energy source for bacterial growth: The invention publishes the use of mining products and sub-products that contain pyrite, such as copper concentrates, and waste from the process in which these concentrates are obtained, known as scavenger tail, as an energy source for the large-scale culture of an association of microorganisms that are useful for ore... Agent: Merchant & Gould PC

20080102516 - Microinjection equipment: To provide a microinjection equipment capable of fitting a micro needle to a manipulator etc. manipulating the micro needle in short time on the occasion of an injection operation. Included are a micro needle transporting device 12 detachably grasping a micro needle 10 filled with an introduction substance and disposed... Agent: Staas & Halsey LLP

20080102517 - Nanocatalyst-based biosensor: Disclosed is a biosensor for electrochemically detecting the presence of an analyte and measuring its concentration. In the biosensor, an organic substance as a substrate is reduced to a substance having an amine group by the catalysis of a nanocatalyst label with a plurality of active sites in the presence... Agent: Sofer & Haroun LLP.

20080102518 - Plate and method for high throughput screening: A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a ledge above a reservoir... Agent: Alston & Bird LLP

20080102519 - Apparatus and method for preparative scale purification of nucleic acids: Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to controllably generate bubbles that reduce the density of the cell debris and create a... Agent: Wong Cabello Lutsch Rutherford & Brucculeri, LLP

20080102520 - Novel human membrane proteins and polynucleotides encoding the same: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.... Agent: Lexicon Pharmaceuticals, Inc.

20080102521 - Stem cell banking system: Disclosed herein are methods for producing a stem cell bank and providing stem cell samples for purchase or use. Also, provided herein are embodiments relating to a stem cell bank and stem cell banking system.... Agent: Beusse Wolter Sanks Mora & Maire

20080102522 - Method of isolating cells from umbilical cord: The present invention relates a method for isolating four cell types from a single umbilical cord as pure cultures. These cell lines (epithelial cells, fibroblasts, smooth muscle cells and endothelial cells) can be characterised and utilised in experimental models and for therapeutic purposes. Particularly, the umbilical cells isolated herein are... Agent: David S. Resnick

20080102523 - Expression vector for animal cell comprising at least one copy of mar dna sequences at the 3'terminal of transcription termination region of a gene and method for the expression of foreign gene using the vector: Provided are an expression vector for an animal cell including a promoter, a cloning site or a polynucleotide encoding foreign product, and a transcription terminator, all of which are operably connected each other within the expression vector, in which at least one copy of human β-globin MAR sequence is attached... Agent: Cantor Colburn, LLP

20080102524 - Freeze-dried composition of inactivated virus envelope with membrane fusion activity: The present invention provides a freeze-dried composition for introducing a foreign matter which comprises an inactivated virus envelope having membrane fusion activity, and at least one stabilizer selected from the group consisting of a protein hydrolysate, leucine, an L-arginine-acid and a polysaccharide, and a method of introducing a foreign matter... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080096188 - Method to predict degradation of a landfill: Determining when a landfill is stabilized by comparing the biological signature of a landfill over a predetermined time period with that of a known stabilized landfill.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080096186 - Pcr primer set for detecting severe acute respiratory syndrome (sars)-coronavirus, method and kit for detecting sars-coronavirus using the same: Provided are SARS-CoV detection PCR primers having nucleotide sequences as set forth in SEQ ID NOS: 1-46, a method for detecting SARS-CoV using the primers, and a SARS-CoV detection kit including the primers.... Agent: Cantor Colburn, LLP

20080096196 - Method for analyzing samples by means of hybridization: o

20080096194 - Method for de novo detection of sequences in nucleic acids: target sequencing by fragmentation: The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic acid. The method is based on combining information about the mass of a fragment, the mass of any one... Agent: Ronald I. Eisenstein

20080096193 - Methods and compositions for detecting polynucleotides: Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a nucleic acid analog that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in... Agent: Donald Silvert Brinks Hofer Gilson & Lione

20080096192 - Nucleic acid amplification assay and arrangement therefor: A nucleic acid amplification assay for quantitative and/or qualitative analysis of the presence of a specific analyte or specific analytes in a biological sample, which analytes, if present, are contained in particles (4) of the sample (2), in which assay the sample is forced in a first direction through a... Agent: James C. Lydon

20080096195 - Salmonella selective enrichment medium containing tetrathionate and magnesium salt: The invention relates to a salmonella selective enrichment medium containing tetrathionate or a salt thereof and at least one type of magnesium salt and to a method for detecting salmonella in a sample by using said selective enrichment medium.... Agent: Alston & Bird LLP

20080096219 - Biological molecule-immobilized chip and its use: e

20080096220 - Novel triazine-based detoxification agents and their use: wherein one X is N and the other X is N, CCL or CCn; A1 and A2 are each independently O, S or N-R1 and R1 is H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or β-phenylethyl; B1 and B2 are each independently an optionally substituted hydrocarbon linkage containing from 1 to... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080096232 - Methods for the detection and diagnosis of trypanosoma cruzi infection: The present invention relates to the diagnosis of Trypanosoma cruzi infection.... Agent: Robert Deberardine Abbott Laboratories

20080096233 - Isolation of immune complexes: The present invention provides methods of detecting and/or isolating immune complexes. The antigen in the immune complexes can further be isolated from the immune complexes to facilitate research and characterization of the antigen. Other embodiments of the present invention can be used to, inter alia, develop assays for detecting immune... Agent: Agilent Technologies Inc.

20080096241 - Method of detecting drug resistant microorganisms by surface plasmon resonance system: The present invention relates to a method and a device for detecting a drug resistant microorganism by surface plasmon resonance (SPR).... Agent: Harness, Dickey & Pierce, P.L.C

20080096245 - Cystatin-based peptide tags for the expression and purification of bioactive peptides: Cystatin-based peptide tags, referred to here as inclusion body tags (IBTs), are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080096246 - Zein-based peptide tags for the expression and purification of bioactive peptides: Zein-based peptide tags, referred to here as inclusion body tags (IBTs), are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080096252 - Production and purification of il-29: The expression vectors and methods using an E. Coli expression system for the large scale production of IL-29 are described. The vectors utilize the IL-29 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Also included are methods... Agent: Zymogenetics, Inc. Intellectual Property Department

20080096255 - Method for preparing sequence tags: Means to circulate any nucleic acid molecule and to obtain from such circular nucleic acid molecules fragments that mark both ends of the initial nucleic acid molecule are provided. Means of high value to studies including, but not limited to, expression profiling, splicing, promoter identification, identification of genetic elements, and... Agent: Alston & Bird LLP

20080096184 - System for exsanguinous metabolic support of an organ or tissue: An exsanguinous metabolic support system for maintaining an organ or tissue at a near normal metabolic rate is disclosed that employs a warm perfusion solution capable of altering the production of nitric oxide (NO) in an organ or tissue and supporting the metabolism of the organ or tissue at normothermic... Agent: Heslin Rothenberg Farley & Mesiti PC

20080096185 - Method for eliminating potentially toxic and/or harmful substances: The invention describes a method for eliminating potentially toxic and/or harmful substances, wherein particles which are capable of binding, taking up and/or carrying the toxic and/or harmful substances, are removed from a body fluid in an extracorporeal step or in an extrinsic or exogeneous device.... Agent: Edwards Angell Palmer & Dodge LLP

20080096189 - Device and method for detection of analytes: The present invention provides assays and devices for detection of substances in liquid samples. The assays and devices utilize passive diffusion between a porous material and a porous membrane containing a specific binding pair member to enable detection of the substance of interest.... Agent: Latimer, Mayberry & MatthewsIPLaw, LLP

20080096191 - Methods and systems for detection and isolation of a nucleotide sequence: A method for isolating nucleic acid molecules having a repeating nucleotide sequence or a homopolymeric nucleotide sequence, e.g. a poly A stretch, is described. In particular, the method uses oligomeric capture probes spiked with various amounts of locked nucleic acid (LNA). The invention further describes methods for the isolation of... Agent: Edwards Angell Palmer & Dodge LLP

20080096187 - Molecular scaffolds for hiv-1 epitopes: Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are... Agent: Alston & Bird LLP

20080096190 - Sequences diagnostic for shrimp pathogens: Primers have been isolated that are diagnostic for the detection of the white spot syndrome virus (WSSV). The primers are based on a new portion of the WSSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080096209 - Analysis of hiv-1 coreceptor use in the clinical care of hiv-1-infected patients: A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a change in coreceptor usage from CCR5 to CXCR4. The change in coreceptor usage to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations... Agent: Frommer Lawrence & Haug

20080096202 - Animal models for demyelination disorders: This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in... Agent: Wilson Sonsini Goodrich & Rosati

20080096201 - Assay for identifying biological targets of polynucleotide-binding compounds: The present invention provides methods and systems for the identification of a biological target of a chemical compound, such as saframycin A, known to bind a polynucleotide. The invention also provides methods of screening chemical compounds for those which act in a similar method and may be more potent than... Agent: Choate, Hall & Stewart/harvard University

20080096208 - Biomarkers for assessing response to c-met treatment: Biomarkers that correlate to treatment with drugs that inhibit c-met are disclosed. These biomarkers have been shown to have utility in assessing response to the compounds. The expression level of the biomarkers is reduced upon treatment with c-met inhibitor compounds, thus indicating that these biomarkers are involved in c-met activity.... Agent: Philip S. Johnson Johnson & Johnson

20080096210 - Cancer suppressing agent: An object of the present invention is to provide a cancer suppressing agent containing a cancer suppressing gene that is discovered through the use of a novel method rather than through existing methods. The present invention provides a cancer suppressing agent which comprises an RGC32 gene or a gene homologous... Agent: Birch Stewart Kolasch & Birch

20080096215 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20080096197 - Compounds and methods for assessment of microsatellite instability (msi) status: The present invention provides a method for assessment of the Microsatellite Instability (MSI) status of medically relevant conditions associated with MSI phenotype such as e.g. neoplastic lesions. The method is based on the analysis of a monomorphic T25 (CAT25) mononucleotide repeat located in the 3′-UTR of the Caspase 2 (CASP2)... Agent: Howrey LLP

20080096211 - Corynebacterium glutamicum genes encoding proteins involved in genetic stability, gene expression, and protein secretion and folding: Isolated nucleic acid molecules, designated SES nucleic acid molecules, which encode novel SES proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SES nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20080096205 - Diagnostic methods and kits for colorectal cancer: The present application discloses a diagnostic method and a kit for prognosis assessment of colorectal cancer (CRC) and a novel tumor suppressor gene to be used for diagnosis of colorectal cancer (CRC), the method comprising the steps of: (a) identifying recurrently altered regions (RAR) on a chromosome; and (b) detecting... Agent: Edwards Angell Palmer & Dodge LLP

20080096207 - Leptin and growth hormone receptor gene markers associated with rearing, carcass traits and productive life in cattle: The invention provides a method for sub-grouping animals according to genotype wherein the animals of each sub-group have a similar polymorphism or combination of polymorphisms in the leptin gene selected from the group consisting of UASMS1, UASMS2, UASMS3, EXON2-FB, and E2JW. The combination of single nucleotide polymorphisms of the leptin... Agent: Frommer Lawrence & Haug

20080096204 - Method and apparatus for determining cancer metastasis: A method which can objectively determine to what extent a cancer cell has metastasized to a lymph node, the method being a method for determining a size of a metastatic focus, including a step of quantitating a tumor marker mRNA in an assay sample prepared from a lymph node suspected... Agent: Sughrue Mion, PLLC

20080096203 - Method and device for detecting quinolone-resistant escherichia coli: The present invention pertains to a method for detecting quinolone-resistant Escherichia coli strains in a biological sample. The present invention also relates to a kit adapted to perform the inventive method.... Agent: Foley And Lardner LLP Suite 500

20080096214 - Method for agitating the fluid contents of a container: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080096213 - Method for confirming conversion treatment and nucleic acid molecule used therefor: There is provided a method for confirming conversion treatment of non-methylated cytosine, including a step of mixing a DNA taken from a living body, with a nucleic acid for accuracy control having a sequence A which is not contained in a genome of the living body and contains cytosine, a... Agent: Sughrue Mion, PLLC

20080096199 - Method for the carry-over protection in dna amplification systems targeting methylation analysis achieved by a modified pre-treatment of nucleic acids: Disclosed is a method for the specific amplification of template DNA in the presence of potentially contaminating PCR products from previous amplification experiments. In the first step DNA is contacted with a bisulfite solution, which reacts with unmethylated cytosines but not with methylated cytosines, by sulfonating them. This results in... Agent: Kriegsman & Kriegsman

20080096212 - Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments: The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus,... Agent: David S. Resnick

20080096216 - Methods and apparatuses for analyzing polynucleotide sequences: Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080096200 - Methods for detection of a target nucleic acid by capture using multi-subunit probes: The invention relates to generating a signal indicative of a target nucleic acid sequence, comprising forming a complex by incubating a sample comprising a target nucleic acid sequence with a probe comprising a first and second subunit, and a binding moiety, and dissociating the first and second subunit to release... Agent: Agilent Techologies Inc

20080096217 - Methods for evaluating pathologic conditions using extracellular rna: This invention provides methods for the detection, diagnosing, monitoring, or predicting of non-neoplastic diseases, pathologic conditions, and injury. The methods of the invention detect extracellular non-neoplastic mammalian RNA in the blood, blood plasma, serum, or other bodily fluid of an animal, most preferably a human, having or predisposed to having... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080096218 - Polynucleotide encoding a maize herbicide resistance gene and methods for use: This invention relates to polynucleotide sequences encoding a gene that can confer resistance to at least one herbicide. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to at least one herbicide, and methods of making said plants... Agent: Pioneer Hi-bred International, Inc.

20080096206 - Polynucleotide sequencing using a helicase: The present invention pertains to a method for sequencing a polynucleotide, comprising the steps of: (i) reacting a target polynucleotide with a helicase/primase enzyme (which may be immobilised), under conditions suitable for enzyme activity; and (ii) detecting the interaction between the enzyme and a nucleotide on the target, by measuring... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080096198 - Primer having promoter region added thereto: It is intended to provide a primer having a promoter region added thereto; and a method of using the primer having a promoter region added thereto in RNA amplification, gene expression analysis and/or identification analysis of an organism. A primer is constructed by adding a promoter region to a random... Agent: Young & Thompson

20080096225 - Assays for detecting modulators of cytoskeletal function: Described herein are methods of identifying compounds which modulate the activity of the cytoskeletal system. The methods are rapid, convenient and sensitive. Preferably, the method is used to identify lead compounds that can be used as therapeutics, diagnostics and agricultural agents. Generally, test compounds are added to two cytoskeletal components... Agent: Medlen & Carroll, LLP

20080096222 - Compositions and methods based upon the kinase haspin: The present invention is directed to methods for increasing or decreasing the phosphorylation of histone H3 using factors that alter the activity of the kinase haspin. The invention includes assays for identifying inhibitors, peptides that can serve as inhibitors or in the generation of antibodies that specifically recognize phosphorylated histone,... Agent: Law Office Of Michael A. Sanzo, LLC

20080096224 - Emission ratiometric indicators of phosphoinositides: Emission ratiometric indicators of phosphoinositides comprise a fusion protein comprising a pleckstrin homology (PH) domain of Akt (also known as protein kinase B) and a “pseudoligand” containing acidic amino acid residues, which is sandwiched between resonance energy transfer (RET) pairs, such as cyan and yellow mutants of GFP (a FRET... Agent: Banner & Witcoff, Ltd.

20080096226 - Method for predicting responsiveness of breast cancer to antiestrogen therapy: The invention is directed to diagnostic and monitoring methods (assays) for cancer and kits that may be used in such methods. More particularly, an aspect of the invention relates to the use of activated Stat5 for diagnosing and monitoring breast cancer and predicting the effectiveness of cancer treatment. The invention... Agent: Conley Rose, P.C. David A. Rose

20080096221 - Method of detecting platelet thrombosis or organ failure: A method of detecting platelet thrombosis or organ failure in a patient suffering from disseminated intravascular coagulation (DIC) or systemic inflammatory response syndrome (SIRS), comprising analyzing a von Willebrand factor-cleaving protease and/or a cleaving factor thereof, is disclosed. A kit for detecting platelet thrombosis or organ failure in a patient... Agent: Heslin Rothenberg Farley & Mesiti PC

20080096223 - Methods and assays for distinguishing between different forms of diseases and disorders characterized by thrombocytopenia and/or by spontaneous interaction between von willebrand factor (vwf) and platelets: The invention relates to a method for distinguishing between different states or forms of diseases and disorders characterized by thrombocytopenia and/or by spontaneous interaction between Von Willebrand Factor (vWF) and platelets, and/or to predict the progression of such a disease or disorder, said method comprising the steps of providing at... Agent: Wolf Greenfield & Sacks, P.C.

20080096227 - Crac modulators and use of same for drug discovery: The invention relates to use of a calcium release activated Ca+2 (CRAC) channel (CRACM) such as CRACM1 and CRACM2 to identify bioactive agents which can modulate store operated calcium entry and CRAC channel activity. The invention further relates to the use of recombinant nucleic acids that encode CRACM. One aspect... Agent: Morgan, Lewis & Bockius, LLP

20080096231 - Simultaneous assay of target and target-drug binding: Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding.... Agent: Baker & Mckenzie LLP

20080096235 - Biomarkers for cancer sensitivity and uses thereof: Disclosed herein are biomarkers and uses thereof for evaluating anti-cancer efficacy and sensitivity.... Agent: Fish & Richardson P.C.

20080096234 - Method for examining carcinoma and adenoma: [MEANS FOR SOLVING PROBLEMS] Significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, between non-carcinoma tissues and carcinoma tissues or adenoma tissues were discovered. The discovery is evidently applicable to detect carcinomas and adenomas (except colorectal carcinomas and colorectal adenomas) specifically by assaying a certain range... Agent: Drinker Biddle & Reath (dc)

20080096236 - Method for detecting the presence of target bacteria or a target component carbohydrate antigen thereof: A process is disclosed for separating a carbohydrate antigen from a Gram-positive or Gram-negative bacteria in a purified form that contains no more than 10% protein. The separated antigen is coupled to an affinity column, over which polyclonal antibodies to the same bacteria are chromatographed and recovered in a purified... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080096228 - Compositions and methods relating to mammalian internal ribosome entry sites: Contemplated compositions and methods are directed to IRES sequences and their use, especially in the context of CML. Among other contemplated aspects IRES sequences described herein are highly active in recombinant in vitro systems and allow high-level of recombinant protein from two, typically opposite reading frames. In vivo, and particularly... Agent: Fish & Associates, PC Robert D. Fish

20080096230 - Methods for assaying percentage of glycated hemoglobin: The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular... Agent: Morrison & Foerster LLP

20080096229 - Modified flagellins and flagellar filaments useful as receptors and methods for the preparation thereof: In general, the invention relates to receptors capable of the efficient recognition and binding of target molecules, said receptors being composed of flagellin proteins which comprise the flagellar filaments of bacteria. More closely, the invention relates to modified flagellins or flagellin fragments useful as receptors, and filamentous receptor-structures comprising them.... Agent: Hahn & Voight PLLC

20080096238 - High throughput assay for human rho kinase activity with enhanced signal-to-noise ratio: The present invention provides a high throughput assay with increased signal-to-noise ration for human Rho kinase activity in vitro, and methods and kits therefor. A high throughput method of assaying a test compound for human Rho kinase modulating activity is also provided.... Agent: Winstead PC

20080096237 - Method for identifying agents which modulate cell growth or survival: The present invention relates to a method for identifying an agent, for modulating cell growth or survival. The method involves the identification of an agent which modulates the net ratio of nuclear-localized versus cytosolic-localized H11 kinase or mutant H11 kinase in a cell. A method for diagnosing a cancer associated... Agent: Licata & Tyrrell P.C.

20080096240 - Novel prostamide receptor antagonists: e

20080096239 - Orphan nuclear receptor: The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monoxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B475

20080096242 - Enhanced substrate conversion efficiency of fermentation processes: The present invention relates to the field of fermentation technology. In particular the invention relates to fermentation processes for the production of a first and a second fermentation product by a single production organism wherein the first product is in a more reduced state than the substrate and the second... Agent: Morgan Lewis & Bockius LLP

20080096243 - Soy protein isolate and process for its manufacture: A soy protein isolate and method for preparing the same are disclosed. The novel soy protein isolate possesses excellent suspension stability and flavor. The process used to produce the soy protein isolate includes an enzyme hydrolysis process, and the resulting soy protein isolate can be used in acidic beverage formulations.... Agent: Solae, LLC

20080096249 - Agarase and gene thereof: Production of efficiently producing agaro-oligosaccharide; a polypeptide having an agarase activity which is usable in, for example, efficiently extracting a substance such as a nucleic acid from an agarose gel; the amino acid sequence of the polypeptide; a gene encoding the polypeptide; a process for producing the polypeptide; a process... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080096244 - D-aminoacylase: A D-aminoacylase produced by a microorganism of genus Defluvibacter; which acts on a N-acetyl-D-amino acid; which has a molecular weight (as determined by electrophoresis) of about 55,000 daltons, and an isoelectric point (as determined by two-dimensional electrophoresis for denatured system) of 5.3; which acts on N-acetyl-D-valine, N-acetyl-D-leucine, and the like,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080096248 - Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems: The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.... Agent: Allergan, Inc.

20080096247 - Nucleic acids encoding duramycin: Nucleic acids encoding preduramycin and produramycin are described, along with recombinant nucleic acids host cells containing the same and methods of use thereof, such as for the manufacture of the lantibiotic duramycin.... Agent: King & Spalding LLP

20080096250 - Toll/interleukin-1 receptor adapter protein (tirap): TIRAP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TIRAP polypeptides and polynucleotides in therapy, and diagnostic assays for such.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080096251 - Invertebrate-derived gonadotropic hormone and its synthesis: The structure of gonadotropic hormone of an invertebrate (Asterina pectinifera) was elucidated. The gonadotropic hormone is a peptide with molecular weight 4500 to 4900 composed of two subunits, wherein the structure of the protein has the structure bound by SS bridges formed between SH residues of cysteines contained in the... Agent: Drinker Biddle & Reath (dc)

20080096253 - Methods of making nanotechnological and macromolecular biomimetic structures: The present invention is in the fields of nanotechology and biomimetics. In particular, the present invention relates to the use of modified ribosomes to produce biomimetic structures. These biomimetic structures, also known as directed element polymers, are not produced by traditional industrial means but instead are produced by living systems... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080096254 - Process for producing alpha1,4-galactosyltransferase and galactose-containing complex carbohydrate: The present invention can provide a process for producing a protein having α1.4-galactosyltransferase activity using a transformant comprising a DNA encoding a protein having α1.4-galactosyltransferase activity derived from a microorganism belonging to the genus Pasteurella and a process for producing a galactose-containing complex carbohydrate using a transformant capable of producing... Agent: Fitzpatrick Cella Harper & Scinto

20080096256 - Method for gene expression: The invention relates to a method for gene expression in a cell-free translation system, wherein the reaction solution comprises an RNA matrix with a gene sequence, which codes for an expression product to be expressed, and a translation system from eukaryotic cells, wherein the reaction solution is incubated, and wherein... Agent: Mayer & Williams PC

20080096257 - Methods for rapid, single-step strand displacement amplification of nucleic acids: A single-step, isothermal strand displacement amplification method that is conducted without the requirement for heat denaturation of the target nucleic acid. The method is particularly useful for analysis of clinical samples due to the decreased risk of potential contamination of the patient sample.... Agent: O''melveny & Myers LLP Ip&t Calendar Department La-1118

20080096258 - Rolling circle amplification of circular genomes: Disclosed are compositions and a method for amplification of circular genomes. The method is based on rolling circle amplification of the circular genomes which involves strand displacement replication by primers. The disclosed method allows differential amplification of circular genomes of interest. In genomic nucleic acid samples containing both a circular... Agent: Needle & Rosenberg, P.C.

20080096259 - Method of aminoacylating trna: It is intended to provide a method of chemically synthesizing an aminoacyl tRNA which is completely different from the existing methods, namely, a highly efficient and practically usable method for synthesizing an aminoacyl tRNA whereby any nonnatural amino acid can be conveniently aminoacylated without a need for genetic engineering techniques... Agent: Rader Fishman & Grauer PLLC

20080096260 - Method of preparing a heat-treated product: The formation of acrylamide during heat treatment in the production of a food product is reduced by treating the raw material with an enzyme before the heat treatment. The enzyme is capable of reacting on asparagine as a substrate.... Agent: Novozymes North America, Inc.

20080096261 - Alcohol production using sonication: A system comprising one or more transducers and an alcohol production facility having a liquid medium processing stream, the alcohol production facility adapted for use with the one or more transducers is provided. In one embodiment, the one or more transducers apply sonication to the liquid medium processing stream in... Agent: Schwegman, Lundberg & Woessner, P.A.

20080096262 - Method for enhancing polymerase activity: A polymerase activity is effectively enhanced by adding an anionic surfactant, in particular an anionic surfactant having a polyethoxyl group, to a reaction mixture containing a polymerase.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080096264 - Attenuated parainfluenza virus (piv) vaccines: The invention provides isolated nucleic acids encoding recombinant genomes or antigenomes of Human Parainfluenza Viruses that are useful as vaccines. The recombinant genomes or antigenomes can be incorporated into expression vectors for production of recombinant viruses in vitro. The invention also provides recombinant Human Parainfluenza viruses having one or more... Agent: Birch, Stewart, Kolasch & Birch, LLP

20080096263 - Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from respiratory syncytial virus: The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products... Agent: Johnathan Klein-evans

20080096265 - Culture medium for the production of filamentary fungi: A culture medium for filamentary fungi comprising at least one carbon source chosen from the group consisting of molasses, malt extract and sucrose a nd at least one organic nitrogen source chosen from yeast extract and corn steep liquor is described; a method for producing filamentary fungi, in particular nematophagus... Agent: Akerman Senterfitt

20080096266 - Method for stabilizing the antiallergic activity of lactic acid bacteria against high-temperature treatment, stabilized compositons, and food and drink: The present invention provides a method for stabilizing an antiallergic activity of lactic acid bacteria against a high-temperature treatment and a composition for the stabilization, which can maintain an antiallergic activity of lactic acid bacteria against a high-temperature treatment, and foods and drinks such as drinks having a stabilized antiallergic... Agent: Foley And Lardner LLP Suite 500

20080096267 - Systems and methods for large-scale production and harvesting of oil-rich algae: Systems and methods for the growing of microorganisms such as algae, yeast, and bacteria are described. Seed fermentation units are associated with final fermentation ponds in various arrangements. Continuous, semicontinuous, fed batch, and batch modes of operation of the seed and final fermentations are included. Harvest methods for the cellular... Agent: Knobbe Martens Olson & Bear LLP

20080096268 - Biotrickling filter packing material and systems and methods of using same to remove odour causing compounds from waste gas streams: The present invention relates to biotrickling filter systems and the packing material employed in such systems, as well as, methods of using same to remove odour causing compounds from waste gas streams. The packing material for the biotrickling filter system includes a plurality of expanded glass granules. When used in... Agent: Fasken Martineau Dumoulin LLP

20080096269 - Plate and method for high throughput screening: A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a ledge above a reservoir... Agent: Alston & Bird LLP

20080096270 - Plate and method for high throughput screening: A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a ledge above a reservoir... Agent: Alston & Bird LLP

20080096271 - Polymeric self-assembly multiplayer membranes for ion screening: design, fabrication and application in sensors: The embodiments of the invention are related to an extrinsically compensated multilayer membrane comprising at least a first layer comprising charged polymers and a second layer comprising neutral polymers, wherein the first layer is characteristic of extrinsic compensation and the charges on the polymer are balanced by mobile counter ions.... Agent: Darby & Darby P.C.

20080096272 - Plate and method for high throughput screening: A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a ledge above a reservoir... Agent: Alston & Bird LLP

20080096273 - Method for preparing conditioned medium of astrocyte-like cells: Disclosed are a method for preparing a conditioned medium of astrocyte-like cells derived from embryonic stem cells, characterized in that astrocyte-like cells, which are prepared by differentiation of embryonic stem cells, are cultured; the medium obtained by said method, the use of the conditioned medium for culturing neural cells as... Agent: Birch Stewart Kolasch & Birch

20080096274 - Recombinant alphavirus vectors and methods of using same: The present invention describes nucleic acid segments, recombinant alphavirus vectors, and recombinant alphavirus particles that include a Sindbis viral vector. The Sindbis viral vector includes a nucleic acid segment encoding a fusion protein comprising a Sindbis virus nonstructural protein and a protein or peptide of interest, wherein the production of... Agent: Dunlap Codding & Rogers, P.C.

20080096275 - Protein for improving cell-attachment efficiency and use thereof: The present invention provides a method for improving cell-attachment efficiency comprising (a) preparing a protein in aqueous solution, wherein the protein has a formula A-B-C, wherein A represents a GRGDS amino acid sequence; B represents a cellulose binding domain (CBD); and C represents a GRGDS amino acid sequence, an RGD... Agent: Wpat, PC Intellectual Property Attorneys

20080096276 - Cis-prenyltransferases from plants: This invention pertains to nucleic acid fragments encoding plant proteins that are homologs to the cis-prenyltransferases UPP synthase from the bacterium Micrococcus luteus or Dedol-PP synthase from yeast Saccharomyces cerevisiae. More specifically, this invention pertains to cis-prenyltransferase homologs from wheat, grape, soybean, rice, African daisy, rubber tree latex and pot... Agent: Pioneer Hi-bred International, Inc.

20080096277 - Plant with reduced protein content in seed, method of constructing the same and method of using the same: It is intended to provide a method of reducing the total amount of stored protein, to develop a technique required therefor, and to provide a plant and its seeds developed by the above method and a method of using such a plant and seeds. More specifically, a nucleic acid molecule... Agent: Perkins Coie LLP

20080096278 - Rf2a and rf2b transcription factors: A method of activating the rice tungro bacilliform virus (RTBV) promoter in vivo is disclosed. The RTBV promoter is activated by exposure to at least one protein selected from the group consisting of Rf2a and Rf2b....