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Chemistry: molecular biology and microbiology

20120122071 - Method of processing allograft skin for transplantation, and cryopreserved allograft skin produced thereby: The present invention relates to a method of processing allograft skin for transplantation and a cryopreserved allograft skin produced thereby. More specifically, the present invention relates to a method in which a cryoprotectant is prepared by adding sucrose to basic constituents comprising dimethyl sulfoxide, an animal cell culture medium and... Agent:

20120122073 - Cis di-ahl modified controls for glycated hemoglobin s-a1c derived from healthy blood cells: The invention is composition comprising red blood cells in an aqueous suspension medium and one or more cis di-ahls; wherein more than 6 percent by weight of the hemoglobin in the red blood cells is S-Alc glycated hemoglobin. In another embodiment, the invention is a method comprising contacting red blood... Agent: Streck, Inc.

20120122072 - Method and system for heating and/or thawing blood products: A device for heating one or more blood product units using electromagnetic (EM) energy is disclosed. The device comprises a chamber sized and shaped for containing at least one frozen blood product unit, a dielectric heating unit for applying electromagnetic (EM) energy at a plurality of frequencies to the at... Agent: Rf Dynamics Ltd.

20120122074 - Mail screening to detect mail contaminated with biological harmful substances: A multi-tier approach for use in a mailroom for detecting bio-threats conveyed by mail. In a first tier procedure, mail entering the mailroom is continuously automatically screened at a mail screening station to detect a potential bio-threat contamination. If a potential bio-threat is detected, an alarm signal is generated, a... Agent: Mesosystems Technology, Inc.

20120122075 - System and method for detecting threatening agents in the air: A multi-tier approach for use in a detecting harmful agents conveyed by the air. In a first tier procedure, the air (in a structure or a predefined area) is continuously automatically screened at a plurality of different predefined locations by air sensors distributed in the area to be monitored. Each... Agent: Mesosystems, Inc.

20120122077 - Method to detect and sequence post translationally modified peptides: A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed.... Agent: Micromass Uk Limited

20120122076 - Purification of antibodies using simulated moving bed chromatography: The present invention relates to compositions and methods for the chromatographic purification of antibodies, such as monoclonal antibodies, employing improved simulated moving bed separation strategies and, in certain embodiments, Raman spectroscopy.... Agent: Abbott Laboratories

20120122081 - Differentiating picorna viruses, nucleic acids therefor, use thereof and bioassay methods employing them: A nucleic acid comprising a 13 base sequence selected from the group consisting of tcGg TtccgCt Gc, tcGgTtccgCc Ac, tcGgTcCcaTcCc, tcGgTtCcaTcCc, ttGgTcCcaTcCc, ttGgTtCcaTcCc, tcGgTcccgTcCc, and tcGgTtccgTcCc, where A and a are adenine, C and c are cytosine, G and g are guanine, and T and t are thymine or uracil,... Agent:

20120122080 - Fluorescence energy transfer by competitive hybridization: A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which have a fluorophore on one probe and a quencher on the other. The fluorophore and quencher are... Agent: Quest Diagnostics Investments Incorporated

20120122079 - Infection detection methods and systems and related compounds and compositions: m

20120122082 - Method and kit for detection of microorganism:

20120122078 - Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (cin) lesion from a suspension sample of cervical cells: Methods of predicting whether a subject has a cervical intraepithelial neoplasia (CIN) lesion are provided. Aspects of the methods include obtaining both morphometric and biomarker data from a liquid cervical cellular sample and then using both types of data to predict whether the subject has a CIN lesion. Also provided... Agent:

20120122083 - Expression vector for producing protein derived from foreign gene in large quantity using animal cells, and use thereof: The present inventors conducted dedicated studies and successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired dihydrofolate reductase gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a... Agent:

20120122085 - Recql4/recql4 variant-p53 complex for altered mitochondrial function in rothmund-thomson syndrome: The present invention discloses a functional interaction of the p53 with RECQL4/RECQL4 variant. The present invention further discloses co localization of RECQL4/RECQL4 variant and p53 complex in the mitochondrial nucleoids. The MLS at the N-terminus of RECQL4 that binds to Tom 20 receptor complex and transport RECQL4/RECQL4 variant-p53 complex into... Agent: National Instutute Of Immunology

20120122084 - System for identifying and sorting living cells: In embodiments of the present invention, a system and method of cytometry may include presenting a single sperm cell to at least one laser source configured to deliver light to the sperm cell in order to induce bond vibrations in the sperm cell DNA, and detecting the signature of the... Agent: 1087 Systems, Inc.

20120122087 - 5-hydroxymethylcytosine as a biomarker for early detection, treatment and prognostic monitoring of cancer: The present invention is related to the use of 5-hydroxymethylcytosine or a biomolecule having general structure of 5-hydroxymethycytosine as a biomarker for the detection, treatment monitoring, and prognostic prediction of cancer.... Agent:

20120122091 - Biological sampling device: A sampling device adapted for transcervical sampling of biological materials from a pregnant patient comprising: an elongate insertion tube (4) having a first end (5) adapted for insertion through the external orifice (external os) of said patient's cervix and a second end (6) including a handle means (7) for manipulating... Agent: Genetic Technologies Limited

20120122094 - Composition and method for stabilizing fluorescent particles: Embodiments of a composition for stabilizing fluorescent signal of nanoparticles and methods for its use are disclosed. In some embodiments, the composition has a pH from 7 to 10 and includes borate, protein and/or protein hydrolysate, an amine, a preservative, and a nonionic surfactant. In particular embodiments, the amine is... Agent:

20120122092 - Compositions and methods for detecting borrelia afzelii: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the p24 gene for the outer surface protein of... Agent: Medical Diagnostic Laboratories, LLC

20120122089 - Gene marker for evaluating genetic potential for marbling in bovine individual and method for evaluating genetic potential for marbling using the same: The present invention provides markers for evaluating a genetic potential for marbling of a bovine individual as well as methods for evaluating genetic potential for marbling using the markers.... Agent: Japan Livestock Technology Association

20120122090 - Gene methylation in cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of cancer.... Agent: Orion Genomics LLC

20120122086 - Method for rapid detection and identification of bioagents in epidemiological and forensic investigations: The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.... Agent: Isis Pharmaceuticals, Inc.

20120122093 - Methods and kits for multiplex amplification of short tandem repeat loci: Compositions, methods and kits are disclosed for use in simultaneously amplifying at least 20 specific STR loci of genomic nucleic acid in a single multiplex reaction, as are methods and materials for use in the analysis of the products of such reactions. Included in the present invention are materials and... Agent: Life Technologies Corporation

20120122088 - Methylation assay: A method for detecting a methylated genomic locus is provided. In certain embodiments, the method comprises: a) treating a nucleic acid sample that contains both unmethylated and methylated copies of a genomic locus with an agent that modifies cytosine to uracil to produce a treated nucleic acid; b) amplifying a... Agent:

20120122096 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122097 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122098 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122099 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122100 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122101 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122102 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122103 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122107 - Homeostatic multidomain protein, and uses for it: The invention relates to the discovery and characterization of mannan binding lectin-associated protein (map44), a new protein that acts in the lectin pathway of complement activation.... Agent: Aarhus Universitet

20120122095 - Materials and methods for the detection of anthrax related toxin genes: Disclosed are methods and kits for identifying a virulent bacteria in a sample, which may include virulent bacteria belonging to the Bacillus genus (e.g., Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis). Typically, the methods include (a) reacting a mixture that includes, in addition to nucleic acid isolated from the sample,... Agent: Eragen Biosciences, Inc.

20120122110 - Method for isolating cells: The present invention relates to a method and kit for the isolation of cells from a sample. The sample is treated with an extraction solution that comprises at least MgCl2 and/or an ionic liquid resulting in the isolation of preferably viable cells.... Agent: Merck Patent Gesellschaft Mit Besdchrankter Haftung

20120122108 - Microfluidic cartridge: The technology described herein generally relates to microfluidic cartridges configured to amplify and detect polynucleotides extracted from multiple biological samples in parallel. The technology includes a microfluidic substrate, comprising: a plurality of sample lanes, wherein each of the plurality of sample lanes comprises a microfluidic network having, in fluid communication... Agent: Handylab, Inc.

20120122106 - Mutation detection assay: A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant copies of the genomic locus that have a point mutation relative to said wild type copies of the... Agent:

20120122109 - Neural progenitor cells derived from embryonic stem cells: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells... Agent: Es Cell International Pte Ltd.

20120122105 - Real time cleavage assay: A cleavage-based real-time PCR assay method is provided. In general terms, the assay method includes subjecting a reaction mixture comprising a) PCR reagents for amplifying a nucleic acid target, and b) flap cleavage reagents for performing a flap cleavage assay on the amplified nucleic acid target to two sets of... Agent:

20120122104 - Triple-stranded nucleobase structures and uses thereof: The present disclosure relates to compositions and methods of using triplex structures generated by a duplex of a polypurine tract and complementary polypyrimidine tract and a triplex-forming nucleobase polymer that hydrogen bonds to both the purine and pyrimidine bases of the polypurine-polypyrimidine duplex.... Agent: Applera Corporation

20120122111 - Rna sequence-specific mediators of rna interference: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long... Agent:

20120122112 - Antibodies as a cancer diagnostic: Method and kits are provided for the detection and diagnosis of metastatic disease. More particularly, the methods and kits employ compounds that can detect EphA2, a specific epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. In one embodiment the compound is an antibody capable of binding to... Agent: Purdue Research Foundation

20120122113 - Signature of secreted protein isoforms specific to ovarian cancer: The present invention relates to the identification of secreted protein isoforms specific in ovarian cancer and methods for diagnosis or prognosis of ovarian cancer in a subject by detecting the secreted protein isoforms.... Agent: Socpra Sciences Sante Et Humaines S.e.c.

20120122114 - Immunoassay for the detection of procalcitonin: The present invention relates to an in vitro method for the detection of Procalcitonin or a fragment thereof of at least 20 amino acid residues in length in a biological sample derived from a bodily fluid obtained from a subject, comprising the steps of: (i) contacting said sample with at... Agent: B.r.a.h.m.s. Gmbh

20120122115 - Bacterial quorum sensing biosensor: The present invention generally relates to fluorescent resonance energy transfer protein compounds and methods for using such compounds as biosensors. The present invention also relates to one or more nucleic acids for encoding the protein compounds, vectors containing the nucleic acids, cells transformed by the vectors, and methods for making... Agent:

20120122119 - Methods of identifying compounds that bind to a toll-like receptor: The present invention is directed to nucleic acid molecules and polypeptides encoding a dsRNA receptor (dsRNA-R). The dsRNA-R contains a THD, interacts with the MyD88 adapter protein, and may bind to dsRNA. The present invention is also directed to antibodies against dsRNA-R and to methods of modulating an immune response... Agent:

20120122120 - Antibodies against human epo receptor: An antibody binding to human EPO-R, characterized in specifically binding pY461, pY430 or p465 is useful for the determination of activated EPO receptor.... Agent: Hoffmann-la Roche Inc.

20120122121 - Antibodies and immunotoxins that target human glycoprotein nmb: The invention provides high affinity antibodies suitable for forming Immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendroglioma cells, and melanoma cells.... Agent: The Government Of The United States As Represented By The Secretary Of Health

20120122122 - Method of diagnosing cancer: A method of diagnosing cancer is provided. The method comprising determining a level of CEACAM1 on isolated peripheral blood lymphocytes (PBLs) of a subject in need thereof, wherein an upregulation of the level of CEACAM1 above a predetermined threshold is indicative of cancer in said subject.... Agent: Tel Hashomer Medical Research Infrastructure And Services Ltd.

20120122117 - Secreted phospholipase a2 biomarkers for arthritis: The present invention relates to the use of protein expression profiles of sPLA2 isoforms with clinical relevance to osteoarthritis (OA). In particular, the invention provides methods for diagnosing OA or determining risk factors for development of OA based on expression of sPLA2-IIA.... Agent:

20120122116 - Use of lymphocytes to measure anthrax lethal toxin activity: It is disclosed herein that isolated lymphocytes, such as human B-cells and CD4+ T-cell can be used to determine an amount of lymphocyte-associated anthrax lethal toxin activity present. Methods of using isolated lymphocytes to identify anthrax therapeutic agents and to determine the efficacy of a potential anthrax therapeutic are disclosed.... Agent: The Government Of The Usa As Represented By The Secretary Of The Dep. Of Health And Human Service

20120122118 - Monclonal antibodies, hybridomas and methods for use: The present invention provides monoclonal antibodies to TM9SF-proteins and hybridoma cell lines that produce the monoclonal antibodies to TM9SF4. This invention also provides a method for determining the level of TM9SF4-protein in biological fluid samples, tissue samples and in microvesicles such as exosomes, comprising kit for determining the level of... Agent: Hansabiomed Ou

20120122126 - Anti-psk antibody: The object of the present invention is solved by an antibody characterized by recognizing PSK and inhibiting anti-tumor activity of PSK. In particular, the inhibition of anti-tumor activity of PSK is an inhibition of cytotoxic activity or an inhibition of anti-TGF-β1 activity of PSK. A physiologically active PSK can, using... Agent: Kureha Corporation

20120122125 - Anti-t. cruzi antibodies and methods of use: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.... Agent: Abbott Laboratories

20120122127 - Cleavage sensitive antibodies and methods of use thereof: We disclose cleavage-sensitive antibodies with epitopes spanning the scissile bond of the toxins molecular target protein, enabling toxin-associated proteolysis to be measured in a variety of assay formats.... Agent: United States Department Of The Army, As Represented By The Secretary Of The Army

20120122123 - Detection of anthrax pathogenicity factors: One major problem in diagnosis methods presently available for anthrax is that these methods require several days to produce a result. The only existing treatment for anthrax requires administration soon after infection at a time when patients are exhibiting only mild flu-like symptoms. Thus, a patient may be days beyond... Agent: The Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services

20120122124 - New bacteriophage adhesion proteins: The present invention relates to bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides. The invention further relates to nucleic acid molecules comprising a sequence encoding the proteins according to the present invention. In addition, the... Agent:

20120122128 - Immuno-based botulinum toxin serotype a activity assays: The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A... Agent:

20120122129 - Rapid nasal assay kit: The present invention relates to an assay which can be used on nasal secretions. The assay is used to determine the cause of nasal secretions, for example whether the secretions are due to an allergic reaction or a non-allergic reaction.... Agent: Toxcure, LLC

20120122130 - Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same: The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence... Agent: Ikeda Food Research Co., Ltd.

20120122131 - Simultaneous detection of metabolic enzyme activity and metabolite levels: Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) a metabolically indicative enzyme and (ii) a metabolic analyte, with a substrate for the enzyme to produce a reaction admixture, under conditions wherein the enzyme is capable... Agent: Perkinelmer Health Sciences, Inc.

20120122133 - Novel devices for the detection of the presence and/or activity of proteases in biological samples: The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples... Agent:

20120122132 - Protein structural biomarkers to guide targeted chemotherapies: A rapid, infrared spectroscopic method has been developed to assess the efficacy of targeted chemotherapeutics against the structure of the polypeptide target, based on the effect of natural polymorphic sequence variation on the conformation of the protein. This method has an advantage over the current genomics-based screening, as the new... Agent:

20120122134 - Novel peptidase substrates: r

20120122135 - Novel peptidase substrates:

20120122137 - Novel nitroreductase enzymatic substrates: The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or... Agent: Biom&#xe9 Rieux S.a.

20120122136 - Self-immolative probes for enzyme activity detection: In this compound, SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an... Agent: Enzo Life Sciences, Inc., C/o Enzo Biochem, Inc.

20120122142 - Cell deposition system: A system for depositing cells on an analysis plate, the cells being contained in a cell suspension including a fixing agent and the cells, included, for receiving the suspension, a chamber (5) which is positioned above the analysis plate and whose base is open and extends opposite a cell depositing... Agent: Novacyt

20120122138 - Consumable component kit: According to the invention there is provided a consumable component kit for use in a system which utilises a liquid culture of a microbiological material, the kit including: a sealed and aseptic culturing vessel; at least one sealed and aseptic chamber for storing a liquid nutrient medium; a sample of... Agent: Cymtox Limited

20120122145 - Insect-based ex vivo model for testing blood-brain barrier penetration and method for exposing insect brain to chemical compounds: There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different chemical compounds in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the... Agent: Entomopharm Aps

20120122144 - Methods employing insect models for determining intestinal absorption of chemical compounds: There is provided insect screening models to determine gastrointestinal absorption of different chemical compounds in vertebrates, and in particular humans, in order to improve the compound screening procedures/processes in the early drug discovery process. This offers many advantages relative to prior technologies since insect models are more reliable tools for... Agent: Entomopharm Aps

20120122139 - Microfluidic device and hemoglobin measurement method using the same: A microfluidic device and a method for measurement of biomaterials using the same. The microfluidic device includes a microfluidic structure including: a sample chamber which receives and accommodates blood; a reagent chamber which contains a luminescent reactant; a first detection chamber which contains a first material that is positively charged;... Agent: Samsung Electronics Co., Ltd.

20120122146 - Nanoparticle screening methods employing insects with blood brain barrier: There is provided an insect model for determining the penetration of nanoparticles through the BBB. The model is also directed to the use of insects for studying the environmental safety of nanoparticles. The particles are administered into the hemolymf of an insect having a BBB, such as the locust, and... Agent: Entomopham Aps

20120122141 - Point source diffusion cell activity assay apparatus: Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from a point source,... Agent: Neuro Probe Incorporated

20120122143 - Technique for determining maturity of a cell aggregation, image processing program and image processing device using the technique, and method for producing a cell aggregation: An image processing program (GP) is configured to comprise a step (A10) for obtaining time lapse images in which a cell aggregation is imaged over a predetermined time interval by an imaging device, a step (A20) for sequentially calculating a feature value relating to multi-layering of the cell aggregation from... Agent: Nikon Corporation

20120122140 - Ultrasonic method for monitoring cell cultures: A method for monitoring a cell culture, where the method includes measuring pulse-echo ultrasonic waveforms from the cell culture, and analyzing the pulse-echo ultrasonic waveforms to monitor the cell culture.... Agent: Utah State University

20120122148 - Media for the specific detection of gram-negative bacteria resistant to beta-lactam antibiotics: m

20120122147 - Real-time method for the detection of viable micro-organisms: The invention relates to a method for real-time detection of viable microorganisms comprising: a. addition of a cell-permeable, phototautomeric compound to a micro-organism or other living cell; and b. measuring the fluorescent emission of said phototautomeric compound. Preferably the phototautomeric compound is salicylic acid, 2-hydroxy-1-naphtoic acid or 1-hydroxy-2-naphtoic acid. Further,... Agent: Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno

20120122149 - Absorbent bead concentration method that eliminates the need for centrifugation: This invention is a technique that enables the concentration of cells, microorganisms, parasite eggs and cysts using absorbent beads, eliminating the need for centrifugation.... Agent: Salubris, Inc

20120122151 - Cytological or histological binding composition and staining methods: A histological and cytological fixing composition, includes at least alcohol, ethylene glycol, dimethyl sulfoxide, water, and sodium chloride. Also, process for preparing this fixer, as well as to its use in particular in processes for staining cells or cellular structures are described.... Agent: R.a.l. Diagnostics

20120122150 - Stabilization method for biological samples by combination of heating and chemical fixation: The present invention provides methods for stabilizing a biological sample for analysis. The invention more particularly provides methods combining heat treatment and chemical fixation of biological samples in order to maintain protein primary structure and post-translational modifications, such as protein phosphorylations.... Agent: Denator Aktiebolag

20120122152 - Treating biomass to produce materials useful for biofuels: Fermentable sugar useful for the production of biofuels can be produced from biomass by contacting the biomass with a solution containing at least one α-hydroxysulfonic acid. The α-hydroxysulfonic acid can be easily removed from the product and recycled.... Agent: Shell Oil Company

20120122153 - Acid-clevable linkers exhibiting altered rates of acid hydrolysis: An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid... Agent: E. I. Du Pont De Nemours And Company

20120122154 - Method of producing lipidated polypeptides: A method of producing a recombinant lipidated polypeptide in E. coli. The method includes providing an E. coli host cell adapted to express a recombinant lipidated polypeptide; and culturing the E. coli host cell in a minimal medium under conditions that allow expression of the polypeptide in lipidated form.... Agent: National Health Research Institutes

20120122155 - Immortalized avian cell lines and use thereof: The present invention relates to specific immortalized avian cell lines expressing telomerase reverse transcriptase (TERT), and exhibiting distinct biologics production patterns. More particularly, the present invention relates to immortalized avian cell line capable of either amplifying Flaviviridae but not capable of amplifying Vaccinia virus strain Copenhagen (W—COP) nor Modified Vaccinia... Agent: Transgene S.a.

20120122156 - Recombinant protein of fibroblast growth factor having adhesive activity for stem cells and method for culturing stem cells using the same: The present invention relates to a recombinant protein of a fibroblast growth factor (FGF) having an adhesive activity for stem cells and a method for culturing stem cells using the same. More particularly, the present invention relates to a recombinant protein having an adhesive activity for stem cells by fusion... Agent:

20120122157 - Signal peptide for producing a polypeptide: The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to... Agent: Novozymes A/s

20120122158 - Pcr for dna that is resistant to amplification: DNA that is difficult to amplify by conventional PCR is amplified by a modified PCR process that includes a high-temperature, short-term heating step as the last step of each thermal cycle, following the conventional denaturing and annealing/elongation steps.... Agent: Bio-rad Laboratories, Inc.

20120122159 - Pcr-based method of synthesizing a nucleic acid molecule: There is provided a method of synthesizing a nucleic acid molecule and in one aspect, the method comprises assembling a full length template nucleic acid molecule by PCR in a PCR reaction mixture comprising a set of assembly oligonucleotides having a first average melting temperature and a set of outer... Agent: Agency For Science, Technology And Research

20120122160 - Thermal cycler and thermal cycling method: A thermal cycler includes a holder to which a biotip having a longitudinal direction is attached in such a manner that one end portion of the biotip is at a higher level than the other end portion, and that the distance between one end portion of the biotip and the... Agent: Seiko Epson Corporation

20120122161 - Sorting asymmetrically tagged nucleic acids by selective primer extension: The present invention provides methods and compositions for amplifying and sorting adapter tagged nucleic acid fragments using selective primer extension. Immortalized pooled polynucleotide samples and method of producing the same are also provided.... Agent:

20120122162 - Enzymatic hydrolysis of pre-treated biomass: This disclosure relates to a method for performing high solids saccharification comprising by (a) providing a cellulosic biomass; (b) pretreating the cellulosic biomass in a pretreatment process to produce a pretreated cellulosic biomass; (c) adjusting said pretreated cellulosic biomass to a solids concentration of 6% to 35% w/w and a... Agent: Andritz Inc.

20120122163 - Microorganism which produces l-amino acid and method for producing l-amino acid using the same: The present invention relates to a microorganism belonging to the genus Escherichia sp. and a method for producing L-amino acid using the same. The microorganism belonging to the genus Escherichia sp. has a sucrose assimilability and L-amino acid producing ability, which is obtained by introducing a gene encoding a sucrose... Agent: Cj Cheiljedang Corporation

20120122164 - Method and system for processing a biomass for producing biofuels and other products: The present invention provides methods of processing a biomass, e.g., for producing lipid and non-lipid materials, by inducing autolysis of a biomass. The biomass may be generated using any species of microorganism and any available biodegradable substrate, including waste materials. The lipid and non-lipid materials are present in two separate... Agent:

20120122165 - Recombinant microorganism and method for producing aliphatic polyester with the use of the same: This invention provides a recombinant microorganism exhibiting excellent aliphatic polyester productivity and a method for producing an aliphatic polyester with the use of the recombinant microorganism. In this invention, the Megasphaera elsdenii-derived pct gene (and/or the Staphylococcus aureus-derived pct gene) and the Pseudomonas sp. 61-3 strain-derived PHA synthase gene (phaC2... Agent: Toyota Jidosha Kabushiki Kaisha

20120122167 - Method for producing lactic acid: Provided is a method for producing lactic acid, which includes: obtaining D-lactic acid or L-lactic acid by carrying out lactic acid fermentation using a lactic acid-producing microorganism under a pressurized condition that exceeds normal pressure and is capable of maintaining lactic acid production activity of the lactic acid-producing microorganism.... Agent: Mitsui Chemicals, Inc.

20120122166 - Mutant methylglyoxal synthase (mgs) for the production of a biochemical by fermentation: o

20120122168 - Recombinant escherichia coli having enhanced acetyl-coenzyme a synthetase activity for producing glyerol and glycerol-derived products: Recombinant E. coli having enhanced acetyl-CoA synthetase activity and the ability to produce glycerol and glycerol-derived products, such as 3-hydroxypropionic acid, methylglyoxal, 1,2-propanediol, and 1,3-propanediol, are described. The recombinant E. coli comprise a promoter operably linked to a nucleotide sequence encoding a polypeptide having acetyl-CoA synthetase enzyme activity, wherein the... Agent: E. I. Du Pont De Nemours And Company

20120122169 - Mutant yqhd enzyme for the production of a biochemical by fermentation: c

20120122170 - in situ production of furfural in a controlled amount in an alcohol production unit from a lignocellulosic biomass:

20120122171 - Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors: The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce... Agent: Genomatica, Inc.

20120122172 - Method for producing ethanol from xylose using recombinant saccharomyces cerevisiae transformed to eliminate functions of genes involved in tor signal transduction pathway: Disclosed is a method for producing ethanol from zylose using a Saccharomyces cerevisiae strain transformed to eliminate functions of genes involved in TOR signal transduction pathways. The method provides an increase in ethanol yield and production efficiency, as compared to a control group, and enables production of ethanol at higher... Agent: Snu R&db Foundation

20120122173 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing in a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor... Agent: Ineos Bio Limited

20120122174 - Non-sterile fermentation of bioethanol: A range of concentrations exists in which fermentation inhibitors derived from pretreatment of lignocellulosic feed stocks inhibit growth of lactic acid bacteria without affecting fermentive yeast. By optimizing levels of fermentation inhibitors to fall within this range, yeast fermentations of lignocellulosic biomass can be conducted under non-sterile conditions with ethanol... Agent: Inbicon A/s

20120122175 - Method and device for operating a fermentation plant: A method for operating a fermentation plant with at least one digester (1) that is supplied with a substrate (1a). The substrate (1a) is percolated using a percolate (2a) from a percolate container (2) and biogas that is generated via the percolation process in the digester (1) or/and in the... Agent: Kompoferm Gmbh

20120122176 - Cellulase cel5h related reagents and their use in microorganisms: The invention relates to applications of the cellulase Cel5H of Saccharophagus degradans and its homologues, functional fragments and/or variants and engineered forms thereof, in the context of recombinant, more particularly solventogenic microorganisms, more particularly C. acetobutylicum. The invention also characterizes a novel domain of the Cel5H cellulase with a putative... Agent: L'universite De La Mediterranee

20120122177 - Viral infection enhancing peptide: The invention relates to a peptide derived from HIV-1 gp120 which forms insoluble aggregates when introduced into an aqueous solution and its use for enhancing viral infection of cells. In addition, the invention comprises methods for enhancing viral infection of cells, for concentrating a virus and for separating a virus... Agent:

20120122178 - Human aminoacyl-trna synthetase polypeptides useful for the regulation of angiogenesis: The present invention provides an isolated polypeptide comprising residues 94-471 of SEQ ID NO: 10, wherein the isolated polypeptide does not comprise amino acid residues 1-47 of SEQ ID NO: 10. Nucleic acids and expression vectors encoding the peptide also are provided.... Agent: The Scripps Research Institute

20120122180 - Incorporation of type iii polyketide synthases into multidomain proteins of the type i and iii polyketide synthase and fatty acid synthase families: Recombinant fusion proteins in which intermediates are covalently bound to the fusion proteins and transferred between domains of the fusion proteins are provided. The fusion proteins include proteins having type I polyketide or fatty acid synthase domains fused with type III polyketide synthase domains. Methods of making such recombinant fusion... Agent: Salk Institute For Biological Studies

20120122179 - Means for purifying a protein of blood plasma and methods for implementing same: An affinity substrate for the selective binding of a protein of blood plasma includes a solid substrate material on which are immobilized deoxyribonucleic aptamers specifically binding with the plasma protein.... Agent: Lfb Biotechnologies

20120122181 - Method for determining antagonist activity to a cytokinin receptor: The present invention provides a method for analyzing agonist-activity to a cytokinin receptor, which comprises (1) bringing an examinee substance into contact with a transformed cell into which DNA coding the cytokinin receptor is introduced and (2) measuring the existence or the quantity of intracellular signal transduction from the cytokinin... Agent: Sumitomo Chemical Company, Limited

20120122182 - Gaussia luciferase variant for high-throughput screening: Described herein is a variant of wild type Gaussia luciferase that catalyzes glow-type emission kinetics suited for high-throughput functional screening applications. Polypeptides, functional fragments, variants, and nucleic acids that encode the enhanced luciferase are further described. One such polypeptide corresponds to wild type Gaussia luciferase with a substitution mutation of... Agent: The General Hospital Corporation

20120122183 - Flocculation with divalent salt and phosphate: A method of flocculating a bacterial cell, producing a protein of interest, from a fermentation broth, comprising a) diluting the fermentation broth up to 1000% (w/w) with water; b) adding a divalent salt to a concentration in the fermentation broth of more than 10 milli moles per liter diluted fermentation... Agent: Novozymes A/s

20120122184 - Polypeptides of strain bacillus sp. p203: m

20120122185 - Chimeric viruses presenting non-native surface proteins and uses thereof: The present invention provides chimeric negative-stand RNA viruses that allow a subject, e.g., an avian, to be immunized against two infectious agents by using a single chimeric virus of the invention. In particular, the present invention provides chimeric influenza viruses engineered to express and incorporate into their virions a fusion... Agent:

20120122186 - Novel bacteriophage strains for the treatment of bacterial infections, especially drug resistant strains of the genus enterococcus: Novel bacteriophage strains are disclosed and their use in the production of preparations for use in the treatment of bacterial infections, particularly with drug resistant strains of bacteria of the genus Enterococcus, particularly those belonging to the species Enterococcus faecalis.... Agent:

20120122188 - Live organism product: A live organism product wherein the organisms are in a dormant state and are suspended in a liquid carrier which is sufficiently devoid of moisture so that the organisms will remain in a dormant state for several months. The carrier is comprised of oil. The carrier may also include an... Agent:

20120122187 - Method for increasing the concentration of colonies of micro organisms in a process for removing contaminants by anaerobic digestion: The present invention refers to a process to increase the concentration of micro organisms' colonies which are formed on the surface of Gramineas bambusoideae in a batch and/or continuous flow process which utilizes biomass as a filtration means in order to remove nitrates as well as organic and inorganic impurities... Agent: Mercosul Comercial Ltda.

20120122189 - Lactobacillus mutant: The present invention discloses a Lactobacillus mutant, which is Lactobacillus paracasei subsp. paracasei PAN 101 and deposited in Agricultural Research Culture Collection (NRRL) in Nov. 13, 2009, and the accession number is NRRL B-50335; Lactobacillus paracasei subsp. paracasei PAN 101 can produce L(+)-lactate, and the production of L(+)-lactate in Lactobacillus... Agent:

20120122190 - Red mold mutant that can increase the production of monascus metabolites: The present invention discloses a Red mold mutant that can increase the production of monascus metabolites, wherein the Red mold mutant is Monascus purpureus NTU 568 and deposited in Agricultural Research Culture Collection (NRRL) in Nov. 13, 2009, and the accession number is NRRL 50338. The disclosed Monascus purpureus NTU... Agent:

20120122191 - Methods for producing secreted polypeptides: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a nucleic acid construct comprising a first nucleotide sequence encoding a signal peptide operably linked to a... Agent: Novozymes, Inc.

20120122192 - Edible oils and food compositions from heterotrophic microorganisms: The invention provides methods of manufacturing oils and oil-based products such as transportation fuels, industrial chemicals, edible oils, lubricants and plastics using sugar cane, sugar cane juice, corn steep liquor, corn starch or depolymerized cellulosic material as a feedstock for bioproduction processes. The disclosed processes utilize oil-bearing microbes as a... Agent: Solazyme, Inc.

20120122193 - Engineered co2 fixing microorganisms producing carbon-based products of interest: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the... Agent: Joule Unlimited Technologies, Inc.

20120122194 - Method for the total gasification of garbage or waste: A method for treating garbage or waste in which the garbage or refuse is subjected to at least one compression step (14) under conditions enabling the separation thereof into a putrescible fraction (15) in the form of a moist pulp, and into a dry fraction (16) with a relative moisture... Agent: D.m.s.

20120122195 - Process for co2 capture using micro-particles comprising biocatalysts: A process for capturing CO2 includes contacting a CO2-containing gas with an absorption mixture optionally within a packed reactor is provided. The absorption mixture includes a liquid solution and micro-particles. The micro-particles include a support material and biocatalyst supported by the support material and are sized and provided in a... Agent:

20120122196 - Methods and products for biomass digestion: Provided herein are methods and products for biomass digestion, which includes the production of biogas, U.S. Environmental Protection Agency classified Class A Biosolids, and pathogen reduced organic liquid fertilizer. Through the digestion of waste materials using sequential phases in an efficient digestion process, enhanced biomass conversion efficiency and improved output... Agent: Landmark Structures I, Lp

20120122197 - Inkjet reagent deposition for biosensor manufacturing: A technique for producing a biosensor includes inkjet printing a reagent onto electrodes of the biosensor. The ink has been specially formulated to allow the reagent to be printed using inkjet printing while at the same time produce commercially viable biosensor. The inkjet printing of the reagent allows for different... Agent:

20120122198 - Biosensor manufacturing method: A biosensor having a first conductive component is described, wherein the first conductive component includes at least one boundary formed by a first processing technique and at least one boundary formed by a second processing technique not the same as the first processing technique. The biosensor can also have a... Agent: Nipro Diagnostics, Inc.

20120122199 - Photobioreactor for the growth and development of photosynthetic and heterotrophic microorganisms: A photobioreactor, especially for the growth and development of photosynthetic microorganism such as microalgae or cyanobacteria. The photobioreactor includes at least one reflector (101) placed on one side of the photobioreactor and tubes arranged in a plurality of layers following one after another along a direction (N) normal to the... Agent:

20120122200 - Biogas plant service device: A biogas plant service device and an associated biogas plant with a service shaft for biogas plants includes a fermentation tank with a tank wall, a fermentation tank interior and a tank cover covering the fermentation tank interior. The service shaft has a service opening to carry out the assembly,... Agent:

20120122201 - Gas flow rate and liquid level monitoring apparatus: An incubator (10) comprising an incubator housing (14), at least one sealable incubation chamber (16) in the housing (14), means for controlling temperature, humidity and gas composition within the incubation chamber (16), a liquid container (26), and a window (24) for observing the gas flow rate and liquid level of... Agent: Planer PLC

20120122202 - Flask for preparing a cytological suspension based on a fixing solution: A system for preparing a cytological suspension is based on a fixing solution. The system containing a cytological sample-taking brush and a flask having an opening for receiving the cytological sample-taking brush are detachably fastened to a handle including a brush-receiving filter basket that is at least partially immersed in... Agent: Maclip

20120122204 - Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna: The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection... Agent:

20120122203 - Methods and kits to generate mirna- and small rna-expressing vectors, and its application to develop lentiviral expression libraries: The invention relates to novel expression systems for microRNAs (miRNAs) based on the expression of the sense and antisense strand from convergent promoters. The invention also provides a method for the direct cloning of small RNAs present in an RNA preparation by the direct ligation of the small RNAs present... Agent: Newbiotechnic, S.a.

20120122205 - Modular dna-binding domains and methods of use: The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specifically recognized by a polypeptide... Agent:

20120122206 - Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity: The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fragments, or a fusion protein that includes a region equivalent to the Fc region of an... Agent: Roche Glycart Ag

20120122207 - Method for expanding monocytes: The invention relates to an ex vivo method for expanding monocytes, macrophages or dendritic cells, which method comprises inhibiting the expression or the activity of MafB and c-Maf in monocytes, macrophages or dendritic cells; and expanding the cells in the presence of at least one cytokine or an agonist of... Agent: Inserm (institute National De La Sante Et De Recherche Medicale)

20120122210 - Carrier peptide fragment and use thereof: A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of... Agent: Toagosei Co. Ltd.

20120122208 - Tubular bioreactor system for use in bone and cartilage tissue engineering: A bioreactor system includes a growth chamber having an inlet, an outlet, and defining a cavity, a media reservoir is in fluid communication with the inlet, and a pump configured to perfuse a media from the reservoir into the inlet and through the growth chamber. A plurality of discrete scaffold... Agent: University Of Maryland, College Park

20120122209 - Undifferentiated stem cell culture systems: The present disclosure provides methods for maintaining and propagating undifferentiated pluripotent stem cells (SC) in suspension. The methods comprise culturing such SC in a non-adherent culture dish under conditions comprising a basic serum free medium and one or more of a basic medium, a serum replacement, an extra cellular matrix... Agent: Hadasit Medical Research Services & Development Limited

20120122211 - Generation of neural stem cells from undifferentiated human embryonic stem cells: The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention... Agent: Es Cell International Pte Ltd.

20120122213 - Method for culturing stem cells: In the field of biological technology, a stem cell culture method is provided. The method includes preparing an amniotic epithelial cell feeder layer that is not treated to lose the division ability; and seeding the stem cells onto the amniotic epithelial cell feeder layer, and culturing in a culture medium.... Agent:

20120122212 - Tgf-beta pathway inhibitors for enhancement of cellular reprogramming of human cells: The present disclosure provides methods and compositions to enhance reprogramming in human cells. In some cases, the method includes contacting human cells with an inhibitor of the TGFβ pathway, for example a TGFβ receptor (TGFβR) inhibitor in combination with one or more induction factors.... Agent:

20120122214 - Method for producing cell medicine: It is an object of the present invention to provide a method for producing a cell medicine that is effective for diseases while causing a low risk to these diseases. The present invention provides a method for producing a phagocyte that expresses a foreign protein, which comprises: a step of... Agent: National University Corporation Kumamoto University

20120122215 - Placental stem cell populations: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.... Agent:

20120122217 - Methods and compositions for reducing target gene expression using cocktails of sirnas or constructs expressing sirnas: The present invention concerns methods and compositions involving the production or generation of siRNA mixtures or pools capable of triggering RNA-mediated interference (RNAi) in a cell. Compositions of the invention include kits that include reagents for producing or generating siRNA pools. The present invention further concerns methods using polypeptides with... Agent: Applied Biosystems, LLC

20120122216 - Oligomeric compounds and compositions for use in modulation of small non-coding rnas: Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment... Agent: Regulus Therapeutics, Inc.

20120122218 - Harnessing cell dynamics to engineer materials: The invention features synthetic materials and methods for inducing cell behavior. Matrix materials induce cell differentiation and cell manipulation based on mechanical and physical characteristics of the materials rather than chemical characteristics.... Agent: President And Fellows Of Harvard College

20120122219 - Porous composite biomaterials and production method of the same: The invention discloses a porous composite biomaterial comprising of poly(γ-glutamic acid)-g-chondroitin sulfate (γ-PGA-g-CS) copolymer and poly(ε-caprolactone). The composite biomaterial provides a three-dimensional microenviroment for using as a scaffold for tissue engineering and for supporting the attachment and proliferation of cells. The invention also discloses a method of producing a porous... Agent:

20120122220 - Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells: A method of preparing a stromal cell conditioned medium useful in expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) establishing a stromal cell culture in a stationary phase plug-flow bioreactor under continuous flow on a substrate in the... Agent: Pluristem Ltd

20120122221 - Culture medium and hydrophilic composite thereof: A hydrophilic composite includes a carbon nanotube structure and a protein layer. The carbon nanotube structure has at least one carbon nanotube film. The protein layer covers one surface of the carbon nanotube structure, and is coupled to the at least one carbon nanotube film. The carbon nanotube structure is... Agent: Tsinghua University

20120122222 - Nanotopographic compositions and methods for cellular organization in tissue engineered structures: The present invention relates to tissue engineered compositions and methods comprising nanotopographic surface topography (“nanotopography”) for use in modulating the organization and/or function of multiple cell types.... Agent: The Charles Stark Draper Laboratory

20120122223 - Mutated protoporphyrinogen ix oxidase (ppx) genes: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.... Agent: Cibus US LLC

20120122224 - Device for performing photochemical processes: Device for carrying out photochemical processes on a microscale and use of the device for photochemical reactions and culturing photosynthesizing cells and/or microorganisms.... Agent: Ehrfeld Mikrotechnik Bts Gmbh

20120122225 - Carrier peptide fragment and use thereof: The method for transferring a foreign substance provided by the present invention includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence WRRQARFK (SEQ ID NO. 1) or any amino acid sequence formed by the substitution,... Agent: Toagosei Co. Ltd.

20120115124 - Irradiation of red blood cells and anaerobic storage: A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon... Agent:

20120115125 - Assay for detecting and quantifying hiv-1: Method of detecting HIV-1 nucleic acids using nucleic acid amplification and a molecular torch hybridization probe. The invented method is characterized by high levels of precision in the quantitation of HIV-1 targets at low copy numbers, and by accurate detection of different HIV-1 subtypes, including M group and O group... Agent: Gen-probe Incorporated

20120115126 - Compositions and methods for rapid, real-time detection of influenza a virus (h1n1) swine 2009: Disclosed are oligonucleotide amplification primers and detection probes specific for the amplification and detection of pathogenic organisms, including for example, specific Influenza A H1N1 viral isolates. Also disclosed is a biological organism identification kit including the disclosed nucleic acid probes and primers, as well as thermal cycling reagents that is... Agent: Longhorn Vaccines & Diagnostics, LLC

20120115129 - Enzyme substrate comprising a functional dye and associated technology and methods: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least... Agent: Biotium, Inc.

20120115130 - Method for detecting target cell: A target cell detection method includes performing a test measurement on a dispersion to obtain a measurement result 1, the test measurement being an optical or electromagnetic measurement, and the dispersion including labeled particles and target cells, the labeled particles being particles on each of which a substance that specifically... Agent: Jsr Corporation

20120115127 - Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity: The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes... Agent: The Regents Of The University Of California

20120115128 - Selective protein labeling: The present invention is related to methods of detecting protein-protein interactions in living cells, as well as detecting the formation and/or inhibition of protein-protein interactions in cells.... Agent: The Board Of Trustees Of The University Of Illinois

20120115133 - Cyanine dyes: The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.... Agent: Biosearch Technologies Inc.

20120115144 - Detection of extracellular tumor-associated nucleic acid in blood plasma or serum: This invention relates to detection of specific extracellular DNA in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease. Specifically, the invention relates to detection tumor-associated DNA, and to those methods of detecting and monitoring tumor-associated DNA found in the plasma or serum... Agent: The Penn State Research Foundation

20120115142 - Endpoint taqman methods for determining zygosity of cotton comprising cry1ac event 3006-210-23: A method for zygosity analysis of the cotton Cry1Ac event 3006-210-23 is provided. The method provides 3006-210-23 event-specific and cotton-genome-specific primers and TaqMan probe combinations for use in an endpoint biplex TaqMan PCR assay capable of determining event zygosity and for assisting in event introgression and breeding.... Agent: Dow Agrosciences LLC

20120115141 - Endpoint taqman methods for determining zygosity of cotton comprising cry1f event 281-24-236: A method for zygosity analysis of the cotton Cry1F event 281-24-236 is provided. The method provides 281-24-236 event-specific and cotton endogenous reference gene-specific primers and TaqMan probe combinations for use in an endpoint biplex TaqMan PCR assay capable of determining event zygosity and for assisting in event introgression and breeding.... Agent: Dow Agrosciences LLC

20120115131 - Genetic lesion associated with cancer: The invention comprises methods for identifying mutations within the 3′ UTRs of genes that lead to increased risk or probability of developing cancer.... Agent: Yale University

20120115132 - Identification of centromere sequences using centromere associated proteins and uses thereof: The present invention is directed to methods of centromere discovery using centromere-associated proteins in a variety of experimental formats. The methods of the invention can be used on any organism, and include using Cal1, Cbf1, Cbf3, Cbf5, CenH3 (Cenp-A), Cenp-B, Cenp-C, Cenp-D, Cenp-E, Cenp-F, Cenp-G, Cenp-H, Cenp-I, Cenp-K, Cenp-L, Cenp-M,... Agent: Chromatin, Inc.

20120115135 - Method for detection of active periodontal disease at the local tooth site: A method for site-specific detection and early diagnosis of periodontal disease using periodontal pocket fluid biomarkers is disclosed.... Agent: University Of Medicine And Dentistry Of New Jersey

20120115139 - Method for evaluating cancer: Provided is a cancer evaluation method using a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject. At least one miRNA selected from hsa-miR-92 and hsa-miR-494 is used as the novel cancer marker in cancer evaluation. The... Agent: Nec Corporation

20120115138 - Method for in vitro diagnosing a complex disease: The present invention relates to a method and kit for in vitro diagnosing a complex disease such as cancer, in particular, acute myeloid leukemia (AML), colon cancer, kidney cancer, prostate cancer; transient ischemic attack (TIA), ischemia, in particular stroke, hypoxia, hypoxic-ischemic encephalopathy, perinatal brain damage, hypoxic-ischemic encephalopathy of neotatals asphyxia;... Agent: Biocrates Life Sciences Ag

20120115151 - Method for testing a subject thought to be predisposed to having metastatic cancer using delta133p53beta: The present invention concerns a method of testing a subject thought to be predisposed to having a metastatic cancer which comprises: analyzing a biological sample from said subject for detecting the presence of a p53 isoform selected from the group consisting of Δ133p53, Δ133p53γ and Δ133p53β, the presence of said... Agent: Centre National De La Recherche Scientifique (cnrs)

20120115146 - Method of analyzing genetically abnormal cells: The present invention relates to a method for analyzing genetically abnormal cells including (a) preparing a cell sample containing eukaryotic cells, (b) conducting an antigen-antibody reaction to cells contained in the cell sample using antibodies which specifically bind to a molecule existing on the cell surface of eukaryotic cells after... Agent: Olympus Corporation

20120115134 - Methods for diagnosis and prognosis of cancer: We have discovered a protein in humans, herein referred to as collagen like gene (CLG) product (SEQ ID NOS: 12 and 13), that is expressed in human prostate cancer and breast cancer cell lines but not in normal adult, placenta, lung, liver, skeletal muscle, kidney or pancreas tissues. We have... Agent: Children's Medical Center Corporation

20120115137 - Methods of predicting osteoarthritis: The present invention relates generally to methods for predicting progression, initiation and susceptibility of osteoarthritis in human subjects using their genotype test results.... Agent:

20120115150 - Mirna biomarkers for the diagnosis of duchenne muscular dystrophy, its progression and for monitoring therapeutic interventions: The invention refers to diagnosis and therapy of muscle degenerative disorders, as Duchenne Muscular Dystrophy (DMD) by means of a class of specific miRNAs.... Agent: Universit&#xc0 Degli Studi Di Roma "la Sapienza"

20120115140 - Molecular diagnosis of fragile x syndrome associated with fmr1 gene: The present invention includes a rapid, selective, and accurate method of diagnosing a human subject with a triplet repeat genetic disorder of the FMR1 gene that leads to fragile X syndrome. The present invention also includes a rapid, selective, and accurate method of diagnosing a human subject at risk for... Agent: Yale University

20120115147 - Neuropsychiatric test reports: Methods and reports for presenting genetic information that is patient-specific and relevant to treatment of neuropsychiatric disorders, including treatment resistant depression. The methods and reports described include genotype information for each of six specific genetic loci and allow patient-specific therapy for the effective treatment of treatment resistant disorders (TRD).... Agent:

20120115136 - Pna diagnostic use: The present invention pertains to certain nucleic acid analogs and related kits that are useful for the capture, recognition, detection, identification, or quantification of certain chemical or biological entities.... Agent: Pna Patent Owners (a/k/a Cig)

20120115148 - Reagents and methods for detecting neisseria gonorrhoeae: This invention provides compositions and methods for detecting Neisseria gonorrhoeae in a sample. This invention also provides related reaction mixtures, kits, systems, and computers.... Agent: Roche Molecular Systems, Inc.

20120115152 - Screening method: The present invention relates to clinical diagnosis of Alzheimer's disease or early-stage Alzheimer's disease in the live patient. In particular, the invention provides a screening method which can be used to assist with diagnosis of Alzheimer's disease in live human subjects, or to identify human subjects with a predisposition to... Agent:

20120115149 - Serotonin transporter gene and treatment of alcoholism: The gene (SLC6A4) responsible for encoding the serotonin transporter (SERT) has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the... Agent: University Of Virginia Patent Foundation

20120115145 - Strand displacement activity of modified polymerases and uses thereof: The present invention is directed to the use of the strand displacement activity of a modified polymerase. The present invention is more specifically directed to a modified Taq DNA polymerase, which exhibits strand displacement activity, whereas the native polymerase does not possess the strand displacement activity.... Agent: Oxitec Ltd

20120115143 - Universal probe assay methods: Reagents and methods are provided for detecting the presence of a target polynucleotide in a sample are disclosed. In one aspect, a method for producing a labeled amplification product by amplifying a target nucleic acid sequence to produce an amplification product comprising the target sequence, a first probe-binding sequence 5′... Agent: Fluidigm Corporation

20120115153 - Marker for prognosis of liver cancer: The present invention relates to a marker for the prognosis of liver cancer; a composition for estimating the prognosis of liver cancer, which contains a substance for detecting a change in the expression level of the prognostic marker for liver cancer; a kit for estimating the prognosis of liver cancer,... Agent: Cbs Bioscience, Co., Ltd.

20120115155 - Method for amplifying nucleic acid: Disclosed is a nucleic acid amplification method which is based on a new principle and enables to amplify a nucleic acid having a specific nucleotide sequence in a simple manner, within a short time and with efficiency. The nucleic acid amplification method comprises the steps of: (a) obtaining a linear... Agent: Toyo Seikan Kaisha Ltd

20120115154 - Reference markers for biological samples: DNA oligomers comprising sequences that are absent from the genome of one or more organisms of interest are used as reference markers (RMs). The RMs are added to biological samples to “tag” and subsequently identify the samples as authentic and to distinguish tagged samples from samples obtained without said markers,... Agent:

20120115157 - Methods for screening for antibiotic compounds: The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.... Agent: Trustees Of Dartmouth College

20120115156 - Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use: Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was... Agent: Institut Pasteur And Centre Nationale De La Recherche Scientifique

20120115158 - Method to determine embryo and oocyte quality based on ceramidase: The present invention relates to a method of predicting the likelihood of embryo or oocyte survival. This method involves providing a sample of an embryo, an oocyte, or surrounding liquid or cells, and screening the sample for ceramidase expression or activity. The ceramidase expression or activity obtained through said screening... Agent: Mount Sinai School Of Medicine

20120115159 - Blood analyzer and blood analyzing method: The present invention provides a blood analyzer and a blood analyzing method capable of obtaining information regarding B lymphocytes and T lymphocytes without using a fluorescence-labeled antibody. The blood analyzer of the present invention includes a blood specimen supplying portion, a sample preparation portion that prepares a measurement sample without... Agent: Sysmex Corporation

20120115162 - Anti-fatty acid amide hydrolase-2 antibodies and uses thereof: Antibodies that specifically bind to fatty acid amide hydrolases and methods of using the antibodies are provided herein.... Agent: Infinity Pharmaceuticals, Inc.

20120115161 - Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growth: Serum-containing and serum-free immunoglobulin inhibitors of steroid hormone responsive cancer cell growth are disclosed, along with their methods of production. Also disclosed are defined cell culture media, assay protocols, and model systems using the inhibitors for demonstrating steroid hormone growth effects of natural and synthetic substances, and other cell culture... Agent:

20120115164 - Mammalian cytokines; related reagents: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering Corporation

20120115163 - Marked peptides and use thereof for assaying circulating irap: A method for the assay of the circulating extracellular portion of the IRAP protein (“insulin responsive aminopeptidase”) includes at least one stage of quantitative assay of the purified, secreted, extracellular portion of IRAP, via at least one labelled peptide, the labelled peptide interacting specifically with the extracellular portion of IRAP.... Agent: Universite Joseph Fourier

20120115160 - Method for detecting invasive microvescles derived from tumor cells: The present application relates to the isolation and analysis of populations of microvesicles, such as populations of microvesicles that are shed by tumor cells and contain the protein ARF6. Invasive microvesicles from tumor cells contain a variety of specific proteins, including ARF6.... Agent:

20120115167 - Method and apparatus for isolating a target bioentity from a biological sample: A method for isolating a target bioentity from a biological sample, comprises contacting the biological sample with a magnetically-labelled ligand having selective binding affinity for the target bioentity, or for a determinant on the target bioentity, to form a target bioentity/labelled ligand complex, locating a separation module having a defined... Agent: Clinical Genomics Pty. Ltd.

20120115165 - Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma: Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.... Agent: University Of Miami

20120115166 - Diagnostic methods for the detection of risk of neurodevelopmental disorders: The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD,... Agent: The Regents Of The University Of California

20120115168 - Bioassay and peptides for use therein: The invention provides a bioassay for detection of Mycobacterium tuberculosis infection comprising artificially modified peptide subsequences of the T-cell epitope from M. tuberculosis Ag85B. Particularly preferred peptides have the form: SGGNNSPAX (SEQ ID 26), where X is Methionine (SEQ ID 18), Leucine (SEQ ID 17), Alanine (SEQ ID 15) or... Agent: Rapid Biosensor Systems Limited

20120115173 - Biomarkers for motor neuron disease: The invention provides methods of determining a diagnosis or prognosis of motor neuron disease in a mammal comprising determining the expression level of one or more proteins or polypeptides of the renin-angiotensin system in a sample taken from a subject. Similarly, aberrant post-translational modification of the proteins or polypeptides as... Agent: University Of Pittsburgh - Of The Commonwealth System Of Higher Education

20120115169 - Hydroxycholesterol immunoassay: Provided is a derivative of 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol,... Agent: Enzo Life Sciences, Inc. C/o Enzo Biochem, Inc.

20120115171 - Method for diagnosing thrombophilia: The invention relates to a method for diagnosing thrombophilia in a subject suffering from HIV or from a systemic auto-immune disease, said method comprising determining in a blood sample obtained from said subject the level of free Protein S having Activated Protein C (APC) cofactor activity and the level of... Agent: Centre National De La Recherche Scientifique-cnrs

20120115172 - Pten/akt methods and compositions relating to bmp: The present invention relates to a purified molecules, including antibodies, that bind specifically to murine β-catenin phosphorylated at amino acid position Serine552 and to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are... Agent:

20120115170 - Serum mg53 as a diagnostic marker for tissue injury: Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a muscle-related disease or disorder. In addition, the invention relates to targeting the native MG53 found in the blood... Agent: Trimedicine, Inc.

20120115174 - Urinary trypsin inhibitors as diagnostic aid for interstitial cystitis: A method aiding the diagnosis of interstitial cystitis involving the combination of an infection marker and an inflammation marker. More specifically, the method includes correlating the presence of urinary trypsin inhibitors in urine with the absence of traditional infection markers in urine to aid in the diagnosis of interstitial cystitis.... Agent: Siemens Healthcare Diagnostics Inc.

20120115175 - Methods for diagnosing elevated right or left ventricular filling pressure: The present invention features a method of diagnosing elevated left or right ventricular filling pressure and cardiovascular dysfunction in a subject by detecting increased levels of sEng in a biological sample from the subject.... Agent: Tufts Medical Center, Inc.

20120115176 - Method for detecting compounds modulating dimers of vft domain membrane proteins: e

20120115177 - Compositions and methods for diagnosis of shock: Methods and kits for diagnosis and staging of shock, and especially non-septic shock are presented in which protease activities and/or volatile compounds are measured from a biological sample to so identify and/or stage shock.... Agent: Anazyme, LLC

20120115179 - Arrangement, substrate and method for preparing a cell sample: A flexible, thin, elongated band is used as a substrate. Similarly to a magnetic tape, the band is unwound from a feed reel and is transported past an outlet opening of a receptacle containing the cells such that the cells are poured onto the band. Subsequently, the band containing the... Agent: Siemens Aktiengesellschaft

20120115178 - Method of diagnosing gastric cancer by using human neutrophil peptide 1-3: Human neutrophil peptide (HNP) 1-3, used as diagnostic and therapeutic molecular probes, are found in clinical tissues of gastric cancer patients. In the analytical process according to the present disclosure, pairs of gastric cancer tissues are used to seek the putative biomarkers by proteomic strategy based on matrix assisted laser... Agent: Atomic Energy Council-institute Of Nuclear Energy Research

20120115180 - Use of animal cells for screening probiotic bacteria strains: The present invention relates to an in vitro and/or ex vivo method of screening probiotic bacterial strains. The present invention also relates to a method of assessing quality of probiotic culture. In addition, the present invention relates to use of animal cells in screening of a probiotic strain. The present... Agent: Suomen Punainen Risti Veripalvelu

20120115183 - Detector arrangement for blood culture bottles with colorimetric sensors: A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference... Agent: Biomerieux, Inc.

20120115182 - Mass spectrometric diagnosis of septicemia: The invention mainly relates to the mass spectrometric identification of pathogens in blood cultures from blood-stream infections (septicemia). The invention provides a method with which microbial pathogens can be separated in purified form from blood after a relatively brief cultivation in a blood culture flask, without any interfering human proteins... Agent:

20120115184 - Method for the detection of mastitis and milk quality and mastitis sensor: A mastitis sensor and a method for detection of mastitis and determination of milk quality in real time (on-line). Methods and apparatuses for the rapid non-invasive determination of the concentration of dissolved molecular oxygen in milked milk are disclosed. Mastitis sensors are disclosed that include a fiberoptic, amperometric or potentiometric... Agent: University Of Tarty

20120115181 - Systems and methods for cerebrospinal fluid collection: A test tube insert includes a flange having a width greater than a width of a mouth of a larger test tube into which the insert is to be inserted. The flange defines a first central opening. An annulus extends integrally downward from the flange. The annulus includes a fenestrated... Agent: King Saud University

20120115185 - device and method for recovering biogas: A device for recovering biogas, comprising at least one fermenter (13) and a percolate tank (10) for collecting the percolate removed from the fermenter or fermenters (13). The percolate tank (10) has a percolate inlet (10c) that can be connected to an outlet of the fermenter or fermenters (13) and... Agent:

20120115186 - Fermentative production of ethanol from glucose, galactose and arabinose employing a recombinant yeast strain: d

20120115187 - Production of recombinant proteins utilizing non-antibiotic selection methods and the incorporation of non-natural amino acids therein: Provided herein are methods and compositions for expression of a nucleic acid construct comprising nucleic acids encoding a) a recombinant polypeptide, and b) a prototrophy-restoring enzyme in a host cell that is auxotrophic for at least one metabolite. In various embodiments, the host cell is auxotrophic for a nitrogenous base... Agent:

20120115188 - Chimeric dna polymerases: The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA polymerases that have at least one distinct functional characteristics (e.g., elongation rate, processivity, error rate or fidelity, salt tolerance or resistance) and methods of making and using the same.... Agent: Kapa Biosystems

20120115190 - Air cooling systems and methods for microfluidic devices: Systems and methods for air cooling a microfluidic device using confinement channels to isolate cooling air from exposed liquids are disclosed. The systems and methods may also thermally condition the cooling airflow for improved robustness of the microfluidic device. In one embodiment, the air cooling system includes a split-level cooling... Agent: Canon U.s. Life Sciences, Inc.

20120115189 - Microfluidic and nanofluidic devices, systems, and applications: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves... Agent: Integenx, Inc.

20120115191 - Production of fructo-oligosaccharide and derivatives by use of aspergillus spp: There is provided a new strain, that is Aspergillus fumigatus, MTCC 5453, and its use in the production of fructo-oligosaccharide. The invention also provides an efficient, rapid and method for increased production of fructo-oligosaccharide by using the strain Aspergillus fumigatus MTCC 5453.... Agent: Godavari Biorefineries Ltd.

20120115192 - Method for production of fermentable sugars from biomass: A process for production of fermentable sugars from biomass using multi-enzyme multi-step system is provided herein. The process disclosed in the present invention provides high yielded sugars in less time period. The multi-enzyme system disclosed in the present invention converts celluloses, hemicelluloses and/or mixture thereof to fermentable sugar with higher... Agent:

20120115193 - Transformation of glycerol and cellulosic materials into high energy fuels: The present invention includes a system and method for making a biofuel comprising: providing a nitrogen-limiting, minimal growth media comprising glycerol, sugars generated from cellulosic biomass or both, under conditions in which an oleaginous microbe converts the growth media into at least one of triacylglycerol, neutral lipids, fatty acids, long-chain... Agent: The Texas A&m University System

20120115194 - Microorganisms for the production of adipic acid and other compounds: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or... Agent: Genomatica, Inc.

20120115195 - Product of fatty acid esters from biomass polymers: The invention provides consolidated bioprocessing methods and host cells. The host cells are capable of directly converting biomass polymers or sunlight into biodiesel equivalents and other fatty acid derivatives. In particular, the invention provides a method for producing biodiesel equivalents and other fatty acid derivatives from a biomass polymer including... Agent: The Regents Of The University Of California

20120115196 - Coryneform bacterium transformant and process for producing isobutanol using the same: e

20120115197 - Ketol-acid reductoisomerase using nadh: Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.... Agent: E. I. Du Pont De Nemours And Company

20120115198 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from anaerobic fermentation of a gaseous substrate containing at least one reducing gas in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This... Agent: Ineos Bio Limited

20120115200 - Continuous process for the production of ethanol from lignocellulosic biomass: A continuous process for the recovery of ethanol from hemicellulose and cellulose from lignocellulosic biomass. Yield of fermentable sugars can be maximized by continuous operation of the pre-treatment system and careful selection of pretreatment conditions including the addition of only small amounts of dilute mineral acid and low pressure. With... Agent: Greenfield Ethanol Inc.

20120115199 - Enzymatic hydrolysis of pretreated lignocellulose-containing material with basidiomycota mycelia and yeast cells: A method for producing a fermentation product from a lignocellulose-containing material comprises pre-treating the lignocellulose-containing material; introducing treated basidiomycota mycelia and/or yeast cells to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to an effective amount of hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation... Agent: Novozymes North America, Inc.

20120115201 - Methods and systems for producing biomass and/or biotic methane using an industrial waste stream: Systems and methods for capture and sequestration of CO2, SOx, NOx, and/or other compounds present in industrial waste streams and use of the captured waste as a nutrient source to support a microbial population. The microbial population can use the nutrients from the industrial waste stream and an energy source... Agent:

20120115202 - Photocatalytic hydrogen production in cyanobacteria: A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed.... Agent: Ramot At Tel-aviv University Ltd.

20120115203 - Method for producing 4-hydroxy-l-isoleucine: A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.... Agent:

20120115204 - Virus filtration of liquid factor vii compositions: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).... Agent: Novo Nordisk Healthcare A/g

20120115205 - Botulinum neurotoxin serotype b activatable botulinum neurotoxin serotype bs: The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located in the di-chain loop region; and method of producing modified Clostridial toxins comprising Clostridial toxin substrate... Agent: Allergan, Inc.

20120115206 - Non-tumorigenic mdck cell line for propagating viruses: The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for... Agent: Medlmmune Way

20120115207 - Enhanced production of papillomavirus-like particles with a modified baculovirus expression system: The present invention is concerned with the provision of a method for manufacturing papillomavirus like particles (PV-VLP), comprising the steps of a) culturing a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises at least one polynucleotide encoding a PV L1 polypeptide, and b)... Agent: Deutsches Krebsforschungszentrum

20120115208 - Modular method for rapid assembly of dna: The invention is directed to methods, kits and compositions using specially designed nucleic acid components for efficient assembly of a DNA construct. The method involves a) incubating a support with a first form of nucleic acid components under conditions to form support-bound nucleic acid component complexes; b) removing unbound first... Agent: The Governors Of The University Of Alberta

20120115209 - Method for culturing microorganisms, bioreactor for implementing same and method for producing such a bioreactor: The present invention thus aims to propose a bioreactor which has an improved yield (concentration, productivity), which is capable of culturing microorganisms sensitive to mechanical stresses, and which is energy-saving. The subject matter of the invention is a method for culturing microorganisms in suspension in a culture medium, in which... Agent:

20120115210 - Outdoor cultivator for photosynthetic microorganisms: A novel waterborne cultivator, which provides the benefits of known systems for culture of photosynthetic micro-organisms in a novel configuration, incorporating a simplified, two-phase rotary mixing and gas injection system, the two phases being liquid and gas (CO2). The mixing system provides optimum growth conditions through increased turbulent vertical mixing... Agent: Element Cleantech Inc.

20120115211 - Apparatus for testing the quality of a fluid sample: Apparatus for testing the quality of a fluid sample comprising a body defining an interior space including a primary chamber and one or more secondary chambers, the apparatus having a first configuration in which it is arranged to hold at least some of the fluid sample in the primary chamber... Agent: The University Of Bristol

20120115212 - Assay tube: A non-instrumented biochemical assay device, such as a device for the processing of clinical specimens for molecular diagnostic applications. In one embodiment, an assay device comprises a lid which covers a reagent tube, which is disposed on a base. The platform utilizes chemical heating and optional temperature modulation by phase... Agent:

20120115214 - Portable high gain fluorescence detection system: An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays... Agent: Micronics, Inc.

20120115213 - Systems for bioagent identification: The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis... Agent: Ibis Biosciences, Inc.

20120115216 - Container for testing for micro-organisms: A multi-compartment resealable container for testing for the presence of micro-organisms is provided with or adapted to receive a sample in a first substantially rigid transparent compartment, a growth medium in a second compartment, and a sanitizer in a third compartment, the compartments being separated by foil seals, the second... Agent: Zyzeba Testing Limited

20120115215 - Light source reflector: A light source reflector includes a structure having three or more internal reflective surfaces defining a first light entry aperture and a second light exit aperture having an area that is greater than the area of the entry aperture. A single light source, or a plurality of uniformly distributed light... Agent: Li-cor, Inc.

20120115217 - Device and method for photosynthetic culture: A device and system for growing a photosynthetic culture is provided which employs one or a plurality of vertically disposed photopanels having interior cavities configured for holding liquid and the photosynthetic culture such as algae. The inner chamber of the photopanels may have a shape that is structurally supported by... Agent:

20120115218 - Bioreactor comprising a mixing chamber: The invention relates to a bioreactor (1) comprising a reactor vessel (41) having a mixing chamber (3) separated by a partition (44) from a reaction chamber (2) located generally above the mixing chamber (3), the mixing chamber (3) having an inlet system (4) for influent or a mixture of influent... Agent: Paques Bio Systems B.v.

20120115220 - Anti-microrna oligonucleotide molecules: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.... Agent: Rockefeller University

20120115219 - High affinity binding site of hgfr and methods for identification of antagonists thereof: Use of a polynucleotide encoding or a polypeptide comprising at least the extra-cellular IPT-3 and IPT-4 domains of hepatocyte growth factor receptor for the screening and/or development of pharmacologically active agents useful in the treatment of cancer, preferably a cancer with dysregulation of hepatocyte growth factor receptor.... Agent: Metheresis Translational Research Sa

20120115221 - Sparc-derived tumor rejection antigenic peptides and medicaments comprising the same: (B) a peptide which consists of an amino acid sequence comprising a substitution or addition of one or several amino acids with respect to the peptide consisting of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has capacity to induce... Agent: Onco Therapy Science, Inc.

20120115222 - Composition and method for maintenance, differentiation, and proliferation of stem cells: Compositions and methods for the proliferation, differentiation, and maintenance of stem cells are described. Preferred are the use of hematopoietic stem cells in combination with a collagen matrix.... Agent: Purdue Research Foundation

20120115223 - Preparation of inactivated artificial antigen presenting cells and their use in cell therapies: Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their generation and use in cell therapy compositions comprising activated cytotoxic T lymphocytes. Inactivated aAPCs are advantageously generated through crosslinking, such as via a photoreaction involving a... Agent:

20120115224 - Culture methods of bone marrow stromal cells and mesenchymal stem cells, and manufacture method of graft cells for central nerve system diseases therapy: In a culture method of the present invention, by culturing bone marrow stromal cells or mesenchymal stem cells under a pseudo micro-gravity environment generated by multi-axis rotation, bone marrow stromal cells or mesenchymal stem cells having an average cell size smaller than that before the culture are obtained. The bone... Agent: Mitsubishi Heavy Industries, Ltd.

20120115226 - 3d culturing systems for growth and differentiation of human pluripotent stem (hps) cells: The present invention relates to the use of 3D culturing systems for the derivation of hepatocyte-like cells from human pluripotent stem cells (hPS). In particular, the invention concerns the directed differentiation and maturation of human pluripotent stem cells into hepatocyte like cells in 3D hollow fiber capillary bioreactors.... Agent: Cellartis Ab

20120115225 - Reprogramming of somatic cells with purified proteins: Purified somatic cell reprogramming factors are described herein. The factors are particularly useful alone or in combination with at least one effector of cellular metabolism, in order to generate at least one reprogramming somatic cell. Methods for using at least one somatic cell reprogramming factor and at least one somatic... Agent:

20120115227 - Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements: The present invention relates to a gene transfer vector (GTV) and in particular to an integrating gene transfer vector (IGTV), which comprises at least one genetic insulator element (GIE), wherein the each comprises at least two copies of an element selected from the group consisting of: a CTF binding site;... Agent: Centre National De La Recherche Scientifique

20120115228 - Oligomeric compounds and compositions for the use in modulation of micrornas: Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA... Agent: Isis Pharmaceuticals, Inc.

20120115229 - Embryonic stem cells and neural progenitor cells derived therefrom: The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving... Agent: Es Cell International Pte Ltd.

20120115230 - Phenylpropanoid related regulatory protein-regulatory region associations: Materials and methods for identifying lignin regulatory region-regulatory protein associations are disclosed. Materials and methods for modulating lignin accumulation are also disclosed.... Agent: Ceres, Inc.

20120115231 - Novel lysophospholipid acyltransferase: The present invention provides novel lysophospholipid acyltransferases. The object of the present invention is attained by the nucleotide sequences of SEQ ID NOs: 1 and 6 and the amino acid sequences of SEQ ID NOs: 2 and 7 of the present invention.... Agent:

20120115232 - Method for inducing degradation of protein in mammalian cell: Provided is a system which can induce the degradation of a protein of interest in a mammalian cell system reliably and stably within a short time. A mammalian cell inducible for protein degradation, the degradation of a protein of interest being induced by an auxin, in which the mammalian cell... Agent: Osaka University

20120115233 - Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof: The present invention relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the leafhopper ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation... Agent: Intrexon Corporation

20120115234 - Down-regulation of gene expression using artificial micrornas: Isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression are described.... Agent:

20120115235 - Enhanced cellulase expression in s. degradans: The invention provides organisms and methods of using and making organisms with enhanced cellulase expression.... Agent: University Of Maryland