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Chemistry: molecular biology and microbiology

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
02/05/2015 > 112 patent applications in 68 patent subcategories.

20150037782 - Enhancement of electromagnetic freezing by stabilization and oscillation of biogenic magnetite particles: Novel methods and systems for electromagnetic freezing are disclosed. An oscillating magnetic field can be applied in conjunction with a static magnetic field in order to align magnetic particles inside biological tissues. Such chains may be naturally present or artificially introduced. Needle-shaped electrodes may be used to produce ions and... Agent:

20150037783 - System and substances for cryopreservation of viable cells: An improved cryopreservation process and substances can involve a cellular collection (1) in a cryopreservation fluid (4) that has been conditioned or treated (7) to enhance the cryopreservation process by adding (18) energy (19) such as in the surface energy of a substance in the cryopreservation fluid (4) prior to... Agent:

20150037784 - Flow regulation in fluidic systems using a phase-change material at system ports: Control of fluid flow in a fluidic network is provided by controlling phase transitions of a phase-change material between a liquid phase and a non-fluid phase. The phase-change material is disposed at ports of the fluidic network where the fluidic network is in communication with an ambient. This advantageously provides... Agent:

20150037786 - Handheld diagnostic system with chip-scale microscope and automated image capture mechanism: A handheld diagnostic system may include a disposable sample holder for receiving and containing a biological sample and an analysis module having a chip-scale microscope. The sample holder may include a plurality of uniformly spaced tick marks. The analysis module may include a sensor for detecting the tick marks as... Agent:

20150037785 - Hybridization assay detection probes for detecting human papilloma virus in a sample: Hybridization assay detection probes targeted to HPV Type 16 nucleic acid sequences which are particularly useful to aid in detecting HPV type 16 are described. The oligonucleotides can aid in detecting HPV Type 16 by acting singly or as part of a detection probe mixture. Compositions, reaction mixtures and methods... Agent:

20150037788 - Dna sequencing by nanopore using modified nucleotides: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.... Agent: The Trustees Of Columbia University In The City Of New York

20150037787 - Polynucleotide configuration for reliable electrical and optical sensing: A mixed polynucleotide includes a first double stranded (ds) portion, a second portion including at least one single stranded (ss) portion, and a third ds portion. The second portion connects the first ds portion and the third ds portion to provide a modified polynucleotide.... Agent: International Business Machines Corporation

20150037799 - Biochip and target dna quantitative method: A biochip used for quantitative analysis of a target DNA contained in a sample. The biochip includes a type I chamber that includes a primer designed to bind to the target DNA, an internal standard DNA of a first amount that has a sequence different from a sequence of the... Agent:

20150037790 - Cytosine variant detection: This invention relates to methods for variant cytosine detection, and kits and probes for variant cytosine detection. In particular the variant cytosine detection is related to detection of methylated cytosine, hydroxymethylated cytosine, carboxycytosine and/or formylcytosine in nucleic acid.... Agent: The University Of Southampton

20150037793 - Detection methods for oil palm shell alleles: Methods, compositions, and kits for determining SHELL genotype and predicting shell fruit form of oil palm plants.... Agent:

20150037797 - Immunoassay for detection of specific nucleic acid sequences such as mirnas: The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using... Agent: Siemens Healthcare Diagnostics Products Gmbh

20150037794 - Marker for diagnosing forelimb-girdle muscular anomaly in mammal individual, and detection method using same: The present invention uses an isolated polynucleotide having a part or whole of GFRA1 gene, mutant GFRA1 protein, and mRNA encoding the mutant GFRA1 protein, each of which includes a loss-of-function mutation of GFRA1, as markers for diagnosing an animal as affected by forelimb-girdle muscular anomaly or as a carrier... Agent:

20150037795 - Method and primer set for detecting mutation: Disclosed herein is a polymerase chain reaction (PCR)-based method for detecting an insertion/deletion variant, as compared with a reference sequence, in a selected region of a target gene in a sample. The target gene has a template strand and a coding strand complementary to the template strand. The method uses... Agent: Mackay Memorial Hospital

20150037791 - Methods and kits for multiplex amplification of short tandem repeat loci: Compositions, methods and kits are disclosed for use in simultaneously amplifying at least 20 specific STR loci of genomic nucleic acid in a single multiplex reaction, as are methods and materials for use in the analysis of the products of such reactions. Included in the present invention are materials and... Agent:

20150037800 - Methods and vectors for producing transgenic plants: Methods of, and compositions for, assembling one or more transcription units in a genome without a linked selectable marker or other unwanted transcription unit are provided. Also provided methods of, and compositions for, assembling one or more transcription units in a genome with a reduced frequency of vector backbone.... Agent: Monsanto Technology LLC

20150037798 - Precursor mirna loop-modulated target regulation: Modulation of mRNA activity is achieved with precursor miRNAs (ta-RNAs). ta-RNAs, primarily pre-miRNAs and pri-miRNAs, including truncated and mutated ta-RNAs, are employed for modulation of mRNA expression where it is found that pri- and pre-miRNA have activity independently of the presence of functional mature miRNAs. Modification of at least one... Agent:

20150037792 - Primers and methods for the detection and discrimination of nucleic acids: The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR.... Agent:

20150037789 - Systemic genotoxicity as blood marker for allergic inflammation: The invention provides a method for detection of allergic inflammation in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammation. The... Agent: The Regents Of The University Of California

20150037796 - Tbl1xr1 and tp63 translocations: This document provides methods and materials involved in detecting translocations of TBL1XR1 and TP63 nucleic acid. For example, methods and materials for detecting TBL1XR1 and TP63 gene rearrangements (e.g., translocations) associated with cancer (e.g., T-cell lymphomas) as well as methods and materials for detecting cancers (e.g., T-cell lymphomas) with a... Agent: Mayo Foundation For Medical Education And Research

20150037804 - 3.4 kb mitochondrial dna deletion for use in the detection of cancer: The present invention broadly claims a method for detecting cancer in an individual. The method comprises detecting a deletion in the nucleic acid sequence between residues 10743 and 12125 in mitochondrial DNA. The method comprises obtaining a biological sample from the individual; extracting the mitochondrial DNA (mtDNA) from the sample;... Agent:

20150037803 - Apparatus and method for automatically analyzing biological samples: Provided are an apparatus and a method for automatically analyzing biological samples capable of performing the entire processes of dissolving the biological samples in protease and cell lysate to dissolve a nucleic acid in a solution, attaching the nucleic acid to magnetic particles, finally washing the magnetic particle to which... Agent:

20150037802 - Fabrication of hierarchical silica nanomembranes and uses thereof for solid phase extraction of nucleic acids: The present invention provides a novel method to fabricate silica nanostructures on thin polymer films based on silica deposition and self-wrinkling induced by thermal shrinkage. These micro- and nano-scale structures have vastly enlarged the specific area of silica, thus the silica nanomembranes can be used for solid phase extraction of... Agent:

20150037801 - Method of amplifying nucleic acid: Provided is a method of amplifying a nucleic acid of a cell involving applying ultrasonic waves to lyse a cell bound to a solid support to provide a cell lysate comprising a nucleic acid; separating the cell lysate from the solid support; adding a protease to the cell lysate; and... Agent: Samsung Electronics Co., Ltd.

20150037805 - Double-stranded nucleic acid, use and kit thereof in ribonuclease detection: Provided are a double-stranded nucleic acid and use thereof in ribonuclease detection, and a ribonuclease detection method and use thereof in tumor detection and/or diagnosis. Specifically, a double-stranded nucleic acid substrate comprises at least one ribonuclease sensitive site. The activity and content of the ribonuclease in a sample are detected... Agent: Suzhou Ribo Life Science Co., Ltd

20150037807 - Direct and continuous root alone or root/shoot production from transgenic events derived from green regenerative tissues and its applications: The present invention provides assays and methods for efficiently testing a polynucleotide of interest for a phenotype in a root. In some embodiments, the assays and methods include regenerating green tissue that is transgenic for at least one polynucleotide of interest into one or more transgenic plantlets that have at... Agent:

20150037806 - Methods and systems for detecting a pathogen in a biological sample: Disclosed herein, inter alia, is method, kit and systems for detecting a pathogen infection in a bodily sample, the method comprising (i) staining said bodily sample with two or more dyes, comprising at least one dye predominantly staining DNA to thereby provide differential staining between DNA and at least one... Agent: Sight Diagnostics Ltd.

20150037809 - Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains: The present invention relates to polypeptides and more particularly to Transcription Activator-Like Effector derived proteins that allow to efficiently target and/or process nucleic acids. Particularly, the present invention reports the characterization of TALE derived proteins that can efficiently target methylated DNA. The present invention more specifically relates to TALE derived... Agent:

20150037808 - System and method for ultrasonic sample preparation: A system and method for ultrasonic sample preparation, includes a vessel having a wall defining an inner volume. An ultrasonic probe is disposed in the inner volume of the vessel. A microplate having a plurality of sample wells is also disposed in the inner volume of the vessel. An actuator... Agent:

20150037810 - Disease pathway-based method to generate biomarker panels tailored to specific therapeutics for individualized treatments: The increased efficacy and reduced unwanted side effects of drugs can be insured by treating only responsive patients. In an embodiment of the invention, signaling pathways that a particular drug interferes with, are derive together with predictive biomarkers and dynamic biomarker that can read the activity of these pathways before... Agent:

20150037812 - Fluorescent protein-based indicators: The presently-disclosed subject matter includes fluorescent protein-based indicators for detecting ions, small molecule analytes, or combinations thereof. In some embodiments the indicators include a polypeptide, which itself includes a fluorescent polypeptide, a compound-binding polypeptide, and a polypeptide target of the compound-binding polypeptide. In some embodiments the polypeptide includes an EosFP... Agent:

20150037811 - Ph-sensitive fluorescent sensors for biological amines: The invention is directed to dual-analyte fluorescent chemosensors for the direct detection and visualization (imaging) of neurotransmitters released upon exocytosis. The inventive sensor exploits the high concentration of neurotransmitters (e.g., glutamate, norepinephrine, and dopamine) and capitalizes upon the pH gradient between the vesicle and synaptic cleft.... Agent:

20150037813 - Antibody against affinity complex: The present invention provides a means and a method for specifically measuring a substance such as a small substance with high sensitivity by a sandwich method. Specifically, the present invention provides an antibody capable of specifically binding to an affinity complex and a method of measuring of the affinity complex... Agent: Fujirebio Inc.

20150037818 - Iron oxide-gold core-shell nanoparticles and uses thereof: Magnetic-optical iron oxide-gold core-shell nanoparticles are disclosed. Methods for making and using the nanoparticles are also disclosed.... Agent: University Of Memphis Research Foundation

20150037819 - Anti-hla monoclonal chimeric immunoglobulin, method and kit implementing such a monoclonal chimeric immunoglobulin: A method for determining the quantity of anti-HLA antibodies of a liquid medium containing antibodies.... Agent: Centre Hospitalier Universitaire De Toulouse

20150037815 - Method for the topographically-selective passivation of micro- and nanoscale devices: Disclosed is a method of preparing a biosensor that involves providing a substrate including a surface having a topographical pattern formed at one or more sites on or in the surface, coating the substrate with a solution including hydrogel particles, wherein the hydrogel particles self-assemble on the surface to mask... Agent: University Of Rochester

20150037814 - Non-invasive enzyme screen for tissue remodelling-associated conditions: Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions.... Agent: Children's Medical Center Corporation

20150037816 - Pcsk9 function assay: Methods and apparatuses for measuring the concentration of functional proprotein convertase subtilisin/kexin type 9 (PCSK9). A method of measuring functional PCSK9 in a sample is provided, by contacting the sample with a PCSK9-binding agent capable of binding to the LDL-R-binding region of a PCSK9; and measuring the amount of functional... Agent:

20150037817 - Bifunctional tumor diagnosis reagent and method for tumor diagnosis: The invention relates to a bifunctional tumor diagnostic reagent and a method for tumor diagnosis. The reagent consists of a protein shell specifically recognizing a cancer tissue and/or a cancer cell and an inorganic nano-core having the catalytic activity of a peroxidase. The bifunctional tumor diagnostic reagent has two functions,... Agent:

20150037820 - Lung cancer markers and uses thereof: Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness... Agent:

20150037822 - Maternal biomarkers for gestational diabetes: Embodiments herein relate to the field of screening tools for fetal/maternal wellness, and, more specifically, to biomarkers for gestational diabetes. In various embodiments, the methods may provide non-invasive and minimally-invasive screening tools for gestational diabetes that involve detection of changes in a proteomic profile of a test sample relative to... Agent:

20150037821 - Methods of identifying hit-antibodies and pf4 antagonists and cell lines for use therein: Methods and cells or cell lines for identifying antibodies or fragments thereof that activate heparin-induced thrombocytopenia (HIT) are described. The methods comprise contacting a hematopoietic cell or cell line that comprises, in operative association, the platelet receptor FcyRIIA under the control of a suitable promoter, and a reporter construct comprising... Agent:

20150037823 - Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereof: The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has applications in the diagnosis of osteoarthritis and/or other ageing-related diseases, in determining the prognosis for an individual diagnosed with osteoarthritis and/or other ageing-related... Agent:

20150037825 - Means and methods for assessing hematopoietic toxicity: The present invention pertains to the field of diagnostics for hematopoietic toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing hematopoietic toxicity. It also relates to a method for determining whether a compound is capable of inducing such hematopoietic toxicity in... Agent: Basf Se

20150037826 - Standard for quantifying pathogenic aggregates from proteins produced naturally in the body: The invention relates to standards for quantifying pathogenic aggregates or oligomers of endogenous proteins which characterize a protein aggregation disease, amyloid degeneration or protein misfolding diseases and use of these standards for quantifying these pathogenic aggregates or oligomers.... Agent:

20150037824 - Urinary biomarker for urinary tract cancer and application of the same: A urinary biomarker for urinary tract cancers and applications of the same are revealed. TACSTD2 is used as a non-invasive urinary biomarker for urinary tract cancers due to a feature that the TACSTD2 protein is increased significantly in urine of patients with urinary tract cancers. The quantitative urinary biomarker shows... Agent: Chang Gung University

20150037827 - Organic thin film transistors and the use thereof in sensing applications: The present invention relates to organic thin film transistors and the preparation and use thereof in sensing applications, and in particular in glucose sensing applications.... Agent:

20150037828 - Metal organic polymer matrices and systems for chemical and biochemical mass spectrometry and methods of use thereof: Aspects of the disclosure include methods for analyzing an analyte composition by mass spectrometry employing a macroporous metal organic polymer matrix. In practicing methods according to certain embodiments an analyte composition is applied to a macroporous metal organic polymer matrix, a voltage is applied to the macroporous metal organic polymer... Agent:

20150037829 - Cytosolically-active peroxidases as reporters for microscopy: An imaging method comprising expressing in cells a Class I heme peroxidase, which optionally is fused with a protein of interest or a cellular localization signal peptide, and contacting the cells with a substrate of the Class I heme peroxidase to allow conversion of the substrate into a product via... Agent: Massachusetts Institute Of Technology

20150037831 - Apparatus for filtering fluid and methods of isolating particle using the same: Provided are an apparatus for filtering a fluid, the apparatus including a first flow channel and a second flow channel which are connected to each other in a fluid communicable manner via a filtration medium, and a method of isolating particles using the apparatus.... Agent: Samsung Electronics Co., Ltd.

20150037830 - Container assembly and associated method: Container assembly including a container for storing a tissue sample and a cover adapted to engage with the container. The cover includes: a top member having a receptacle, a seal for sealing off the receptacle, a puncturing member for breaking the seal by displacement of the puncturing member. The container... Agent: Ax-lab Innovation Aps

20150037832 - Methods of facilitating the bioconversion of crude biodiesel-derived glycerol by microorganisms: The present disclosure generally pertains to a method of facilitating the bioconversion of glycerol by microorganisms. In one embodiment, biodiesel derived crude glycerol is purified by removing fatty acids through acid precipitation. The fatty acid-free crude glycerol is then utilized as a carbon source for the culture of microorganisms and... Agent:

20150037833 - Container and system for sample collection and preparation: The present invention relates to a system for collecting and preparing a body fluid sample, the system comprising a sample container (10) comprising a sample cup (38) for receiving the sample, said sample cup comprising graduated indicator markings (14) corresponding to equal increments of sample volume, a removable lid (16)... Agent: Northwestern University

20150037834 - Fluorogenic ph sensitive dyes and their method of use: e

20150037835 - System and method for automated diagnosis: An automated microscope apparatus comprises an outer housing having an external wall; optionally but preferably an internal wall in the housing configured to form a first compartment and a separate second compartment in the outer housing; a microscope assembly in the housing (preferably in the first compartment); a microprocessor in... Agent:

20150037836 - Temperature controlled dissection and observation stage: A temperature controlled tissue dissection and observation stage comprises a central working area and a first temperature controlled station positioned within the central working area. The first temperature controlled station comprises a first temperature controlling element configured to adjust the temperature of the first temperature controlled station. The stage further... Agent:

20150037837 - Cytological method using the auto fluorescence of white corpuscles for the early diagnosis and the monitoring of infections: The present invention relates to an in vitro method for diagnosing the infectious state of an individual on the basis of a sample of white corpuscles arising from a biological specimen taken from an organ potentially infected by a pathogenic micro-organism of said individual, comprising at least the following two... Agent: Universite Paris-sud 11

20150037838 - Production of astaxanthin and docosahexaenoic acid in mixotrophic mode using schizochytrium: New strains of protists belonging to the Schizochytrium genus, allow high-yield production of lipids and carotenoids, in particular of astaxanthin and docosahexaenoic acid (DHA), in mixotrophic mode, and a method for selecting and culturing such strains, using a variable and/or discontinuous light source, in particular a flashing light.... Agent: Fermentalg

20150037839 - Production of lutein in mixotrophic mode by scenedesmus: Novel strains of microalgae belonging to the Scenedesmus genus enable the production of lipids, in particular lutein, in mixotrophic mode, as well as a method for selecting and culturing the strains using a variable and/or discontinuous supply of light, in particular in the form of flashes.... Agent: Fermentalg

20150037840 - Side-chain protected oligopeptide fragment condensation using subtilisins in organic solvents: Method for enzymatically synthesising an oligopeptide, comprising the coupling of an (optionally N-protected) protected oligopeptide ester with an (optionally C-protected) protected oligopeptide nucleophile in an organic solvent or an organic solvent mixture having a water content of 0.1 vol % or less, by a subtilisin in any possible form.... Agent: Enzypep B.v.

20150037841 - Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least... Agent:

20150037842 - Modified bacterial cell: The disclosure relates to a Gram negative bacterial cell that is transformed with a nucleic acid molecule that encodes a Gram positive twin-arginine translocase and including methods for the production of polypeptides.... Agent:

20150037843 - Polynucleotide configuration for reliable electrical and optical sensing: A mixed polynucleotide includes a first double stranded (ds) portion, a second portion including at least one single stranded (ss) portion, and a third ds portion. The second portion connects the first ds portion and the third ds portion to provide a modified polynucleotide.... Agent: International Business Machines Corporation

20150037844 - Liquefaction and saccharification of granular starch at high concentration: The present teachings provide methods of processing granular starch in slurries containing high dry solids content. The slurries are initially incubated with enzymes at or below the gelatinization temperature. The use of pullulanase and glucoamylase at specified doses allows for improved glucose yields at lower energy cost.... Agent:

20150037846 - Method for biomass hydrolysis: Methods and systems for biomass hydrolysis are disclosed. The methods use wash liquor in a sequencing process to maximize sugar yields, particularly C5 saccharides.... Agent: Renmatix, Inc.

20150037848 - Method for producing saccharide: The invention provides a method for producing saccharide, the method including the following steps (1) and (2). In step (1), a cellulose raw material is heated in the presence of one or more additives selected from the group consisting of a nonionic surfactant and polyethylene glycol; and water, at a... Agent: Kao Corporation

20150037847 - Method of producing a composition containing galacto-oligosacchardies: The present invention relates to a method of producing compositions containing galacto-oligosaccharides as well as to galacto-oligosaccharide-containing compositions as such.... Agent: Arla Foods Amba

20150037845 - Thermophilic mutants of trichoderma reesei endoglucanase i: The present disclosure relates to mutant thermostable glycosyl hydrolases family 7 enzymes, including mutant Trichoderma reesei endoglucanase I. In particular, the present disclosure relates to mutant thermostable enzymes, compositions containing the enzymes, and methods of use thereof.... Agent: The Regents Of The University Of California

20150037849 - Microorganisms for the production of 5-hydroxytryptophan: Recombinant microbial cells and methods for producing 5-hydroxytryptophan (5HTP) using such cells are described. More specifically, the recombinant microbial cell comprises an exogenous gene encoding an L-tryptophan hydroxylase, and means for providing tetrahydrobiopterin (THB). Related sequences and vectors for use in preparing such recombinant microbial cells are also described.... Agent:

20150037850 - Recombinant microorganism producing quinolinic acid and a method for producing quinolinic acid using the same: The present invention relates to a quinolinic acid-producing recombinant microorganism expressing a fusion protein of L-aspartate oxidase and quinolinate synthase linked via a linker, and a method for producing quinolinic acid using the same.... Agent:

20150037851 - Variant lovd polypeptides and their uses: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound... Agent:

20150037852 - Method and system for reducing free fatty acid content of a feedstock: A method for reducing the free fatty acid content of a feedstock includes the steps of providing a free-fatty-acid-containing feedstock, treating the free-fatty-acid-containing feedstock to reduce the free fatty acid content thereof, where the step of treating includes combining at least one of an algae and a coagulant to the... Agent:

20150037853 - Methods and systems for chemoautotrophic production of organic compounds: The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products... Agent:

20150037854 - Diterpene synthases and method for producing diterpenoids: Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof.... Agent:

20150037855 - Fermentative production of alcohols: The invention relates to the fields of industrial microbiology and alcohol production. The invention also relates to the development of a microorganism capable of producing fermentation products via an engineered pathway, and uses of the microorganism. The invention also relates to the methods to improve cell viability and productivity and... Agent:

20150037857 - Oil compositions and methods of production: The present invention relates to methods of making an oil product from plant material that is used to make alcohol (e.g., ethanol) via fermentation. The methods extract oil from the plant material (e.g., corn oil from corn) before exposing to the fermented plant material to distillation temperatures so as to... Agent:

20150037856 - Rapid and low cost enzymatic full conversion of lignocellulosic biomass: Methods are provided for improved processing of lignocellulosic biomass. Hydrothermally pretreated lignocellulosic biomass is subject to separate hydrolysis and fermentation (SHF) or prehydrolysed and subject to simultaneous saccharification and fermentation (SSF) at high initial loadings of cellulase enzymes, at least 15 FPU/g DM. The cellulase enzymes are subsequently recycled and... Agent: Inbicon A/s

20150037859 - Composition of lignin pellets and system for producing the same: A system for treating biomass for the production of a composition of lignin pellets is disclosed. Pellets comprising at least 50 percent lignin by dry weight is disclosed. Also disclosed are pellets produced from a lignin composition by a process comprising: pre-treating lignocellulosic biomass into pre-treated biomass; separating the pre-treated... Agent:

20150037858 - Method for producing ethanol: A method for producing ethanol from lignocellulosic biomass using yeast at low cost is provided. The method of the present invention for producing ethanol from lignocellulosic biomass includes steps of (1) pretreating lignocellulosic biomass, (2) treating a cellulose fraction obtained in Step (1) with a cellulose hydrolase, (3) mixing saccharified... Agent:

20150037860 - Methods for biosynthesis of isoprene: This document describes biochemical pathways for producing isoprene by forming two vinyl groups in a central precursor produced from isobutyryl-CoA, 3-methyl-2-oxopentanoate, or 4-methyl-2-oxopentanoate as well as recombinant hosts for producing isoprene.... Agent:

20150037861 - Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities: The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms via the heterologous expression of the mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus.... Agent:

20150037862 - Over-production of secondary metabolites by over-expression of the vea gene: The invention provides a general and facile method to obtain secondary metabolites from fungal sources. The invention is based on the discovery that the fungal gene veA and protein encoded thereby regulates the activity of multiple secondary metabolite gene clusters in fungi. Over expression of the gene veA provides increased... Agent:

20150037863 - Method of forming a multilayer aggregate of objects: A method of forming a multilayer aggregate of objects in a channel including a liquid, the method including: a) providing objects at first and second superposed regions of the channel, b) obtaining first and second aggregates of objects, optionally by applying transverse acoustic waves, preferably stationary waves, within each region... Agent:

20150037864 - Processing of sperm cells: A process for separating sperm cells from a chemical compound by electrophoresis comprising subjecting the sperm cells to an electric potential between a cathode and an anode such that the sperm cells are separated from the chemical compound, and related methods including methods of using said sperm cells in intrauterine... Agent:

20150037865 - Compositions for causing, enhancing, and/or expediting oxo-biodegradation of articles and methods of production and use thereof: Kits and assemblies for causing, enhancing, and/or expediting consumption of an article by at least one biodegradative living organism are disclosed. The kits and assemblies include at least one additional living organism that enhances and/or expedites consumption of the article by the at least one biodegradative living organism. Methods of... Agent:

20150037866 - Composition, method and kit for obtaining purified recombinant proteins: Compositions relating to a combination of two types of separation matrix; and to variant host cells which contain at least one essential host protein that is fused to an affinity binding tag or has been mutated to replace at least two of a plurality of histidines or basic amino acids... Agent: New England Biolabs, Inc.

20150037867 - Purification method: The invention provides methods for purifying protein products.... Agent:

20150037868 - Engineered proteins with a protease cleavage site: Various aspects and embodiments herein relate to recombinant proteins with at least one protease recognition sequence that can be inactivated by a cognate protease and methods of preparing such proteins. In some embodiments, recombinant phosphoglucose isomerase (Pgi) proteins are provided. In other embodiments, recombinant phosphotransacetylase (Pta) proteins are provided. In... Agent: Greenlight Biosciences, Inc.

20150037869 - Transaminase biocatalysts: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.... Agent:

20150037870 - Enzyme catalysts for diels-alder reactions: The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other aspects, the invention provides methods of making the enzyme catalysts, including by de novo computational design. The present invention thereby provides enzyme catalysts capable of... Agent: University Of Washington

20150037871 - Therapeutic nuclease compositions and methods: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.... Agent:

20150037872 - Protein variants having modified immunogenicty: The present invention relates to a method of selecting a protein variant having modified immunogenicity as compared to the parent protein comprising the steps obtaining antibody binding peptide sequences, using the sequences to localise epitope sequences on the 3-dimensional structure of parent protein, defining an epitope area including amino acids... Agent:

20150037874 - Chimeric adenoviruses for use in cancer treatment: The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.... Agent:

20150037873 - Method for endotoxin removal: The present invention relates to a method for endotoxin removal from a sample comprising the following steps: combining the sample comprising one or more target molecule(s) with a chromatography media comprising beads having an inner porous core functionalized with ligands capable of binding endotoxin and an outer porous layer without... Agent: Ge Healthcare Bio-sciences Ab

20150037875 - Process of lysing yeast cell walls: The invention relates to the use of a composition comprising at least one polypeptide having glucoamylase activity and optionally at least one polypeptide having β-1,3-endoglucanase activity in a process of lysing yeast cell walls as well as to a process for lysing yeast cell walls which comprises exposing said yeast... Agent: Ab Enzymes Gmbh

20150037876 - Multi-channel fluorescence detecting module and nucleic acid analysis system having the same: Provided are a multi-channel fluorescence detecting module and a nucleic acid analysis system including the multi-channel fluorescence detecting module. The nucleic acid analysis system includes: a plurality of loaders configured to accommodate a plurality of cartridges respectively, the cartridges comprising microfluidic devices; a transfer module including a linear actuator, the... Agent: Samsung Electronics Co., Ltd.

20150037877 - Method of simultaneous frequency-sweeping lifetime measurements on multiple excitation wavelengths: A fast fluorescence lifetime microscopic system images FRET between multiple labels in live cells and deep tissue, using a quantitative analysis method to reconstruct the molecular machinery behind the multiplexed FRET phenomenon. The system measures fluorescence lifetime, intensity and anisotropy as images of excitation-emission matrices (EEM) in real time and... Agent: The Arizona Board Of Regents On Behalf Of The University Of Arizona

20150037878 - Portable system for brewing compost tea: Embodiments disclosed herein disclose a system for brewing compost tea. The system includes a bucket that has an opening and a handle. A lid defining a plurality of holes and is configured to cover the opening in the bucket. An air pump is coupled to the lid. At least one... Agent:

20150037879 - Thermal cycler and thermal cycling method: A thermal cycler includes a holder to which a biotip having a longitudinal direction is attached in such a manner that one end portion of the biotip is at a higher level than the other end portion, and that the distance between one end portion of the biotip and the... Agent:

20150037880 - Dna encoding canine monomeric crp and expression vector containing the dna: Pentameric CRP is produced at a high efficiency by transferring DNA, which encodes monomeric CRP, into a silkworm to thereby construct a transgenic silkworm and then collecting and purifying pentameric CRP that is produced by the transgenic silkworm constructed above.... Agent:

20150037881 - Proteins used for the diagnosis of lyme borreliosis: A nucleic acid encoding a chimeric protein, the chimeric protein including (i) at least one amino acid sequence having at least 50% sequence identity with any of the amino acid sequences selected from the group consisting of SEQ ID NOS: 1-5, and (ii) at least one amino acid sequence having... Agent: Biomerieux

20150037882 - Scalable process for therapeutic cell concentration and residual clearance: Apparatus and corresponding method for concentration and washing of live mammalian cells, for preparation of human cell therapy products. Optimized parameters for a temperature regulated, completely closed, fully disposable and scalable counterflow centrifugation separation system having integrated disposables designed for both the input cells and output cells are provided.... Agent: Lonza Walkersville, Inc

20150037883 - Method for derivation and long-term establishment of ground state pluripotent embryonic stem cells: The various embodiments herein provide a method for derivation and long term establishment of ground state pluripotent embryonic stem cells. Further the embodiments herein provides a method to inhibit the ERK and TGF β signalling pathways for long term maintenance of the embryonic stem cells. The R2i mouse embryonic stem... Agent: Royan Institute

20150037884 - Tissue scaffold: A tissue engineered construct made totally or in part from biocompatible materials and mammalian cells and/or cell products is provided. These constructs are useful in regenerating complex tissues such as bone, ligament and tendon, which may fabricated into medical devices suitable for use in the treatment of injuries and maladies... Agent:

20150037885 - Method of producing human retinal pigmented epithelial cells: The production of human retinal pigment epithelial cells having a step of incubating human pluripotent stem cells with binder molecules binding to terminal N-acetyllactosamine (Galβ1-4Glc NAc) and/or blood group H determinant type 2 (Fucα1-2Galβ1-4Glc NAc). A method of using lectin ECA in a culture of human pluripotent stem cells in... Agent: Glykos Finland Oy

20150037887 - Method for producing nk cell-enriched blood preparation: It is intended to provide a method for producing an NK cell-enriched blood preparation, which is low invasive and is capable of conveniently and rapidly growing NK cells, etc. in blood collected from an organism. The NK cells in blood are stimulated with NK cell growth-stimulating factors comprising an anti-CD16... Agent: Biotherapy Institute Of Japan

20150037888 - Polypeptides targeting vascular endothelial growth factor receptor-2 and alpha v beta 3 integrin: Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization.... Agent:

20150037889 - Polypeptides targeting vascular endothelial growth factor receptor-2 and alpha v beta 3 integrin: Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization.... Agent:

20150037886 - Treatment drug for autoimmune diseases and allergic diseases: The present invention provides an agent for the prophylaxis or therapy of autoimmune diseases or allergic diseases, which contains an anti-Embigin antibody, particularly an anti-Embigin antibody showing cytotoxicity or a cytotoxicity inducing activity, an agent for the prophylaxis or therapy of diseases involving Th17 cell, and a cytotoxic agent to... Agent:

20150037890 - Methods and apparatus for transplantation of nucleic acid molecules: In exemplary implementations, transplantation of nucleic acids into cells occurs in microfluidic chambers. The nucleic acids may be large nucleic acid molecules with more than 100 kbp. In some cases, the microfluidic chambers have only one orifice that opens to a flow channel. In some cases, flow through a microfluidic... Agent: Massacusetts Institute Of Technology

20150037891 - Methods for enhancing infectivity of retroviruses: The present invention provides methods for producing retroviruses or viral vectors with enhanced infectivity. The methods entail transfecting a retroviral vector into a packaging cell that has suppressed expression or inhibited enzymatic activity of a parvulin prolyl peptidyl isomerase (parvulin PPIase), and culturing the transfected packaging cell to allow production... Agent:

20150037892 - Recombination system: The present invention relates to a method for carrying out recombination at a target locus.... Agent:

20150037893 - Pathogen resistant plant cells and methods of making: The present invention relates to genetically modified plant cells that have reduced expression or activity of at least one amino acid efflux transporter and/or at least one mineral efflux transporter compared to levels of expression or activity of the at least one amino acid efflux transporter or mineral efflux transporter... Agent:

  
01/29/2015 > 123 patent applications in 68 patent subcategories.

20150031012 - Automated intracytoplasmic sperm injection assisted fertilization system: An integrated automated system comprising a microfluidic cassette, and methods of use thereof, for intracytoplasmic sperm injection assisted fertilization. The microfluidic cassette and the integrated automated system provides a complete set-up of human gametes for assisted in vitro fertilization, including proper cell stage recognition, gamete propulsion via microfluidic currents, microinjection... Agent:

20150031013 - Diagnostic agent for tumor: It is to provide a tumor diagnostic agent and a tumor determination method enabling not only determination of the presence or absence of a tumor in a subject, but also determination of whether the tumor is a malignant tumor or a benign tumor, which can be used simply at low... Agent:

20150031014 - Detecting analytes with a ph meter: Provided herein are sensors, kits that include such sensors, and methods for making and using such sensors. The sensors permit detection of a broad array of target molecules, such as nucleic acids (e.g., DNA and RNA), proteins, toxins, pathogens, cells, and metals, and can be used in combination with pH... Agent: The Board Of Trustees Of The University Of Illinois

20150031015 - Identification of poliovirus strains: The present invention relates to methods for identifying and/or distinguishing polioviral strains, in particular polioviral strains used in vaccine production. The methods are based on selective hybridisation with oligonucleotides, i.e. primers and/or probes, that allow to distinguish between closely related but different polioviral strains on the basis of nucleotidepolymorphisms existing... Agent: En Sport

20150031017 - Methods for detecting human papillomavirus-assocated cancers: The present invention provides probes and methods of use thereof in the diagnosis and/or prognosis of certain types of cancers, particularly human papillomavirus (HPV)-associated cancers. The probes are designed for hybridization with genomic material in a manner indicative of one or more aberrations in the genetic material present in the... Agent:

20150031018 - Methods for diagnosing feline coronavirus infections: Provided is a method for determining whether a feline is infected with pathogenic Feline Infectious Peritonitis Virus (FIPV) or Feline Enteric Infection Virus (FECV). The method involves determining the presence or absence of intact or mutated S1/S2 and S2′ cleavage sites in the spike protein of serotype 1 feline coronaviruses... Agent:

20150031016 - Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial... Agent: Diagnostic Hybrids Inc.

20150031019 - Computer assisted sperm profile analysis and recognition: The invention described herein relates to a device that will discriminate between normal sperm, and sperm that can look morphologically normal, but with >5% DNA fragmentation using an expert system that will allow the embryologist to select morphologically and genetically normal sperm.... Agent: Cellcura As

20150031020 - Enzyme-pore constructs: The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. The constructs can be used to generate transmembrane protein pores having a nucleic acid... Agent:

20150031031 - Apparatus for collecting fingerprints and buccal swabs: Disclosed are devices and methods for collection, labeling and matching biological samples containing nucleic acid in conjunction with collecting at least one ridge and valley signature such as a fingerprint or footprint of an individual. Such devices and methods are used in forensic, human identification, paternity, tissue typing, and screening... Agent: Life Technologies Corporation

20150031022 - Dna methylation markers and methods of use: The present invention provides methods for identifying metastases by detecting nucleic acid hypermethylation of one or more genes in one or more samples, and in particular in the lymph nodes. The invention further relates to DNA methylation as a predictor of disease recurrence and patient prognosis, specifically in the field... Agent: The Johns Hopkins University

20150031026 - Enhanced ligation reactions: In some embodiments, methods for ligating nucleic acid ends comprise: conducting a nucleic acid ligation reaction in the presence of at least one agent that generates a ligatable terminal 5′ phosphate group by removing an adenylate group from a terminal 5′ phosphate of a nucleic acid. In some embodiments, an... Agent:

20150031024 - Enzymatic preparation of 10 base to 50 kb double-strand dna reagent for sequencing with a nanopore-polymerase sequencing device: The invention herein disclosed provides for devices, reagents, and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore. Of particular note is the use of reagents to rapidly sequence a polynucleotide. The invention is... Agent: The Regents Of The University Of California

20150031025 - Genetic products differentially expressed in tumors and use thereof: The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in aberrant... Agent: Ganymed Pharmaceuticals Ag

20150031033 - Method and kit for detection of cancer, and therapeutic agent for cancer: The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA.... Agent: Sapporo Medical University

20150031030 - Method for analysing foetal nucleic acids: The invention relates to a method for analyzing fetal nucleic acids from the supernatant of the culture medium of fetal cell cultures of an in vitro fertilization, comprising the steps: a) removing from the culture vessel used for cultivating the fertilized egg cell the cell-free supernatant of the in vitro... Agent: Ivf Zentren Prof. Zech - Bregenz Gmbh

20150031023 - Method of detecting nucleic acids containing a genetic variation: Provided are a composition or a kit for detecting a nucleic acid with genetic variation including a first amplification blocking nucleic acid and a second amplification blocking nucleic acid, and a method of detecting a nucleic acid with genetic variation by using the same. Based on the above, a nucleic... Agent: Samsung Electronics Co., Ltd.

20150031029 - Method of detecting residual genomic dna and a kit thereof: The present disclosure relates to a highly specific and sensitive method of detecting host cell impurities in a biological sample by using quantitative real time polymerase chain reaction (q PCR). The present disclosure also provides novel designed primer and probe to amplify only the specific Alu family of dispersed repetitive... Agent:

20150031028 - Method of dna detection and quantification by single-molecule hybridization and manipulation: The present invention relates to a fast method for the detection and the quantification of a nucleic acid, DNA or RNA. Specifically, the invention provides a method for detecting and quantifying the presence of a specific nucleic acid molecule which is based on physical and electronic treatments. The method of... Agent:

20150031034 - Methods and compositions for detecting genetic material: This invention provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some cases, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). The methods and materials described apply techniques... Agent:

20150031032 - Methods and compositions for determining indication for prostate biopsy: The present invention provides a method of identifying a subject for whom a prostate biopsy is indicated, comprising: a) determining, from a nucleic acid sample obtained from the subject, a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele... Agent:

20150031021 - Methods and nucleic acids for determining the prognosis of a cancer subject: The invention provides methods, nucleic acids and kits for determining the prognosis of a subject having cancer. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.... Agent: Epigenomics Ag

20150031027 - Use of saa1 beta/beta homozygote in the prognosis diagnosis and diagnosis of liver cirrhosis: Provided is uses of SAA1β/β(1.5/1.5) homozygote in prognosis and/diagnosis of liver cirrhosis, and in preparation of a reagent for liver cirrhosis prognosis and/or liver cirrhosis diagnosis. Recognition of liver cirrhosis susceptible populations can be achieved by detection of human SAA1β/β homozygote and non-SAA1β/β homozygote through real-time fluorescence quantitative allele specific... Agent:

20150031043 - Determining paired immune receptor chains from frequency matched subunits: The invention is directed to methods for determining nucleic acids that encode immune receptor chains originating from the same cell, that is, paired immune receptor chains. Methods of the invention comprise high-throughput sequencing of rearranged nucleic acids encoding immune receptors from one or more samples of lymphocytes. In one aspect,... Agent:

20150031040 - Devices, apparatus, kit and method for treating a biological sample: Method for the treatment of a biological sample comprising at least one cell and a liquid component; according to the method, a force is applied to the sample inserted in an inner chamber of a hollow device towards a filter which has pores with diameters from 2 nm to 1... Agent: Silicon Biosystems S.p.a.

20150031044 - Gravitational fluctuation stress loading method, aircraft, aircraft-flying method, method for promoting serotonin-producing gene expression, serotonin-producing method, method for stimulating central nervous system, and efficacy-measuring method: A gravitational fluctuation stress loading method capable of causing a new acute stress reaction in a subject or a laboratory animal is provided. A gravitational fluctuation stress loading method including at least one first stress-loading step (S1) of placing a stress load on the subject or the laboratory animal by... Agent:

20150031045 - Markers for diagnosing amyotrophic lateral sclerosis: Disclosed herein are markers for diagnosing amyotrophic lateral sclerosis (ALS) and for monitoring efficacy of treatment for ALS. These markers allow for early detection of ALS, namely before the onset of clinical symptoms. Also disclosed herein are methods for diagnosing ALS in a subject in need thereof, for monitoring the... Agent:

20150031035 - Method and device for collection and amplification of circulating nucleic acids: Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-cellular fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random... Agent: General Electric Company

20150031041 - Method of evaluating inhibitory effect on damp-dry malodor: A method of evaluating inhibitory effect on damp-dry malodor, containing the steps of: bringing microorganisms which produce damp-dry malodor-causing substances and a test substance into contact with each other in the presence of a sebaceous dirt component; detecting expression of at least one kind of gene selected from a fatty... Agent: Kao Corporation

20150031042 - Method of identifying vdj recombination products: The invention relates to a method of identifying VDJ recombination products which comprises the use of sequence specific enrichment and specific restriction endonuclease enzymes or other DNA-shearing approaches to provide high resolution and high throughput interrogation of antigen receptor repertoires.... Agent: The Babraham Institute

20150031039 - Methods and device to balance radiation transference: A method and device for adjusting the temperature of a sample by heating a substrate with a laser diode light; said light projected on to the substrate to absorb the light and convert the light energy to a heat energy thereby raising the temperature of the substrate corresponding to the... Agent: Agency For Science, Technology And Research

20150031037 - Micro-reactor device: In some aspects, the present disclosure provides a magnetic rack comprising a lateral movement structure and/or a longitudinal movement structure. In particular embodiments, the lateral movement structure and/or longitudinal movement structure move one or more magnets to or away from a reaction tube, in order to control the magnetic forces... Agent:

20150031036 - Nucleic acid amplification reaction apparatus and nucleic acid amplifying method: A nucleic acid amplification reaction apparatus includes (A) a rotating body mounted with a nucleic acid amplification reaction container including reaction liquid in which nucleic acid is eluted and oil phase-separated from the reaction liquid, (B) a control section for rotating the rotating body and moving the reaction liquid back... Agent:

20150031038 - Sample preparation methods: The present invention provides whole blood nucleic acid extraction methods, compositions, and kits, as well as nested isothermal amplification methods, compositions, and kits. In certain embodiments, these methods are applied to detecting Lyme disease, including in patients without classic erythema migrans skin lesions.... Agent:

20150031046 - Bioanalytical reagent used in heterogeneous phase and usage method thereof: A bioanalytical reagent used in a heterogeneous phase and a usage method thereof are provided to increase the signal intensity from the bioanalytical reagent. The bioanalytical reagent includes a target detector and a signal generator. The signal generator is represented by the following formula: (p1) y-(a trigger)z-(LS) N-a degradable polymer... Agent:

20150031051 - Image analysis and measurement of biological samples: Methods, devices, apparatus, and systems are provided for image analysis. Methods of image analysis may include observation, measurement, and analysis of images of biological and other samples; devices, apparatus, and systems provided herein are useful for observation, measurement, and analysis of images of such samples. The methods, devices, apparatus, and... Agent:

20150031048 - Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the... Agent: The Johns Hopkins University

20150031049 - Method of predicting acute appendicitis: Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers: leucine-rich α-2-glycoprotein (LRG); S100-A8 (calgranulin); α-1-acid glycoprotein 1 (ORM); plasminogen (PLG); mannan-binding lectin serine protease 2 (MASP2); zinc-α-2-glycoprotein (AZGP1); Apolipoprotein D (ApoD); and α-1-antichymotrypsin (SERPINA3); are increased... Agent: Children's Medical Center Corporation

20150031047 - Methods and systems for the rapid characterization of functional biological molecules: In one non-limiting aspect, the invention provides a method for detecting the quality of a biological molecule comprising forming a first mixture of ingredients comprising: (i) a first binding agent that specifically binds to a tag, wherein the first binding agent is attached to a solid support; (ii) a decoy... Agent: Bioscale, Inc.

20150031050 - Method of screening therapeutic agent for treating inflammatory diseases: Uses and applications derived from the discovery of a novel binding site of IKK-β, such as method of screening a therapeutic agent as drug candidate for treating cancer, inflammation, or other diseases/disorders, are provided.... Agent:

20150031053 - Assay and method for determining insulin-resistance: The present invention provides for a home test or a point of care test device that can both detect blood glucose and insulin levels and methods using said device. The device and methods can be used to aid diabetic patients and medical practitioners to fine tune insulin administration, and to... Agent: Alere Switzerland Gmbh

20150031054 - Method and system for diagnosing alzheimer's disease: Disclosed herein is a method for diagnosing Alzheimer's disease capable of minimizing invasiveness to reduce the risk of infection. The method for diagnosing Alzheimer's disease includes the steps of: pretreating an intranasal specimen; detecting tau protein or amyloid beta peptide (Aβ) in the pretreated intranasal specimen; comparing a value of... Agent:

20150031052 - Method for reducing adsorption of bubbles: Provided is a means for improving measurement accuracy in an immunoassay using a dry plastic cell. A method for reducing adsorption of bubbles onto a cell side surface in an immunoassay, the method including carrying out a reaction and/or measurement in a presence of a surfactant, wherein the immunoassay comprises... Agent: Denka Seiken Co., Ltd.

20150031055 - Novel bioactive lipid derivatives, and methods of making and using the same: Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate)... Agent: Lpath, Inc.

20150031056 - Development of specific immunoassay critical reagents for pharmacokinetic assessments of peptide polymers in preclinical and clinical matrices: The present disclosure provides methods of developing a specific immunoassay for the Pharmacokinetic assessments of peptides, peptide oligomer and polymer including Glatiramer Acetate (GA), also known as Copolymer 1, Copolymer-1, Cop 1 or Cop in the clinical and preclinical matrices.... Agent:

20150031057 - Method for the determination of renal function: Method for the determination of the renal function wherein the amount of at least one agrin fragment derived by neurotrypsin cleavage of agrin is measured in a sample taken from a patient and the measured amount of the agrin-fragment in the sample is used as indicator for renal function.... Agent:

20150031058 - Driving patient compliance with therapy: Methods of the invention involve determining a patient's compliance with a cholesterol lowering therapy. In certain aspects, the invention provides methods that involve conducting a first assay to determine a cholesterol biomarker level in a first sample from a patient prior to the patient undergoing a cholesterol lowering therapy. The... Agent: Boston Heart Diagnostics Corporation

20150031060 - Fad-conjugated glucose dehydrogenase gene: Disclosed herein are a gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase which can be characterized by reactivity to glucose, thermal stability, substrate-recognition performance, and low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; a method for the determination of... Agent: Ikeda Food Research Co., Ltd.

20150031059 - Novel glucose dehydrogenase: An object of the present invention is to provide a novel glucose dehydrogenase, a method for producing the glucose dehydrogenase, and applications of the glucose dehydrogenase. The flavin-binding glucose dehydrogenase of the invention has the following characteristics (1) and (4): (1) Molecular weight: the molecular weight of a polypeptide moiety... Agent: Toyobo Co., Ltd.

20150031061 - Compositions and methods relating to fusion protein biomarkers: The present invention provides fusion proteins as biomarkers specific for chromosomal translocation-based conditions (e.g., cancer), related methods for detecting fusion protein biomarkers associated with chromosomal translocation-based conditions, related methods for quantifying amount of fusion protein expression, and related methods for diagnosing chromosomal translocation-based conditions through detection of such fusion protein... Agent:

20150031062 - Method for sorting of pluripotent cells: A method for sorting pluripotent cells using a compound which is eliminated from the pluripotent cells through the MDR1 transporter.... Agent:

20150031065 - Compositions, methods and kits for diagnosis of lung cancer: The present invention provides methods for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. The present invention also provides compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof... Agent:

20150031063 - Method of detecting at least one mechanism of resistance to carbapenems by mass spectrometry: The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterised in that the antimicrobial is a carbapenem, and said resistance... Agent: Biomerieux, Inc.

20150031064 - Multiple biomarker panels to stratify disease severity and monitor treatment of depression: Materials and Methods for identifying and measuring pharmacodynamic biomarkers of neuropsychiatric disease (e.g., major depressive disorder), stratifying disease severity, and monitoring a subject's response to treatment are provided.... Agent:

20150031068 - Methods and compositions for detecting immune system activation: The present invention relates to methods and compositions for detecting immune system activation and/or the presence of an immune disorder in a patient. More particularly, methods and compositions for detecting immune system activation and/or the presence of an immune disorder in a patient by detecting, for example, the concentration of... Agent: Lycera Corporation

20150031067 - Novel fluorescent sensor for metal cation detection based on 2-(2'-hydroxyphenyl)benzazole containing a schiff base moiety: Hydroxyphenylbenzazole compounds that are useful for the selective detection of zinc, aluminum, chromium, and iron cations in vitro and in vivo. The Hydroxyphenylbenzazole compounds include a 2-hydroxyphenyl group bound to a single benzazole group; a first ligand group that is a Schiff base moiety; and a second ligand group selected... Agent:

20150031070 - Optically sensitive cell network: A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected from any solid support having a shear modulus above 1 GPa.... Agent:

20150031069 - Phylogenetic analysis of mass spectrometry or gene array data for the diagnosis of physiological conditions: A universal data-mining platform capable of analyzing mass spectrometry (MS) serum proteomic profiles and/or gene array data to produce biologically meaningful classification; i.e., group together biologically related specimens into clades. This platform utilizes the principles of phylogenetics, such as parsimony, to reveal susceptibility to cancer development (or other physiological or... Agent:

20150031066 - Systems, methods, and apparatus for sample dispersion: Some embodiments comprise a sample dispersion system including a sample container having a housing with two or more orifices to control the introduction of said fluid and/or the passage of carrier solution into the sample container and/or the passage of fluid from the sample container. The carrier fluid may be... Agent: Union Biometrica, Inc.

20150031073 - Apparatus and method for biological sample processing: An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate... Agent:

20150031071 - Method and system for distributing and agitating an amount of liquid over a microscope slide: A system and method for distributing and agitating an amount of a liquid over a microscope slide, wherein a distribution plate having a microtextured lower surface and at least one passage extending through the plate is secured at a predetermined distance of 10-250 μm above the microscope slide. Liquid passes... Agent: Victorious Medical Systems Aps

20150031072 - Sample taking device: Sample taking device for extracting a fluid sample from a vessel comprising: a cover portion for closing the vessel such that, in use a headspace is defined between the cover portion and fluid held in the vessel, a sampling chamber comprising a sampling inlet and a sampling outlet, a cannula... Agent: Hexascreen Culture Technologies, S.l.

20150031074 - Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample: A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification... Agent:

20150031075 - Method of detecting a salmonella microorganism: A composition is provided for detecting a Salmonella microorganism in sample. The composition comprises at least one first selective agent that inhibits the growth of Gram-positive microorganisms, a first differential indicator system comprising at least one first differential indicator compound that is converted to a first detectable product by a... Agent:

20150031076 - Transformed cells that ferment pentose sugars and methods of their use: The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the host cell the ability to convert xylose to xylulose which may be further metabolized by the... Agent:

20150031077 - Conversion systems for biomass: The efficient production of ethanol from low-cost biomass (e.g., corn, sugar beets, sugar cane, switchgrass and/or paper) has become increasingly important in making ethanol competitive with gasoline and decreasing the United States' dependence on foreign oil. For example, to reduce the cost of transporting biomass to ethanol production facilities, mobile... Agent:

20150031080 - Cellobiohydrolase variants and polynucleotides encoding same: The present invention relates to variants of a parent cellobiohydrolase II. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.... Agent:

20150031078 - Kluyveromyces lactis yeast strain and methods for the production of sugars, ethanol, beta-galactosidase and biomass: The present invention is a Kluyveromyces lactis yeast strain comprising the sequence identified by SEQ ID NO: 1, and methods for the production of sugars (glucose and galactose), ethanol, β-galactosidase and biomass, in which said Kluyveromyces lactis yeast strain is cultured in the presence of a lactose-containing medium. The lactose-containing... Agent: Queizuar, S.l.

20150031079 - Polypeptides having xylanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent:

20150031083 - Adenoviral-based biological delivery and expression system for use in the treatment of osteoarthritis: The invention relates to an adenoviral-based biological delivery and expression system for use in the treatment or prevention of osteoathritis in human or mammalian joints by long-term inducible gene expression of human or mammalian interleukin-1 receptor antagonist (Il-1Ra) in synovial cells, comprising a helper-dependent adenoviral vector containing a nucleic acid... Agent:

20150031081 - Methods and materials for reducing degradation of recombinant proteins: Described herein are methods and materials for reducing degradation of recombinant proteins in fungal cells such as Yarrowia.... Agent:

20150031082 - Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent:

20150031084 - Methods and systems for producing products using engineered sulfur oxidizing bacteria: Methods and systems for producing a biofuel using genetically modified sulfur-oxidizing and iron-reducing bacteria (SOIRB) are disclosed. In some embodiments, the methods include the following: providing a SOIRB that have been genetically modified to include a particular metabolic pathway to enable them to generate a biofuel; feeding a first source... Agent:

20150031085 - Novel leech hyaluronidase and its application: The present invention provides a novel leech HAase and a method of producing low-molecular-weight HA oligosaccharides using the leech HAase. This invention successfully cloned the first leech HAase gene and provides a method for high-level expression of the leech HAase gene. By controlling the incubation condition, different HA oligosaccharides, particularly... Agent: Jiangnan University

20150031088 - Gene synthesis process, gene chip and kit: Provided is a chip process of gene synthesis, and the process comprises incorporating the whole procedure, which comprises amplifying oligonucleotides and assembling the oligonucleotides into a gene in parallel, onto a single chip. A specific mismatch endonuclease is also used in the process to establish an error repair system in... Agent:

20150031086 - Ligase-assisted nucleic acid circularization and amplification: Provided herein are methods for generation and amplification of a single-stranded DNA circle in a single reaction vessel from a linear DNA without any intervening purification steps. The single-stranded DNA circle is generated via a template-independent single-stranded DNA ligation. Whole-genome amplification of circulating nucleic acids extracted from blood is provided.... Agent: General Electric Company

20150031087 - Nucleic acid amplification method: The invention provides an ultra-rapid nucleic acid amplification method performed in a flow channel. Specifically, the invention provides a nucleic acid amplification method for performing a PCR reaction by supplying a PCR sample solution to a nucleic acid amplification device comprising a serpentine channel adapted to perform at least one... Agent: National Institute Of Advanced Industrial Science And Technology

20150031089 - Dna assembly using an rna-programmable nickase: This disclosure provides, among other things, a method of combining nucleic acid fragments, comprising: (a) providing two double-stranded DNA molecules with a common sequence, wherein the common sequence is at the end of each molecule; (b) nicking one strand in the common sequence of both molecules at a respective nicked... Agent:

20150031090 - Methods and compositions for targeted genomic deletion: Disclosed herein are compositions and methods for generating chromosomal translocations and targeted deletions of specific lengths and at specific locations the genome of cell.... Agent:

20150031091 - Polypeptides having alpha-amylase activity and polynucleotides encoding same: The present invention provides isolated polypeptides having alpha-amylase activity catalytic domains, carbohydrate binding domains and polynucleotide encoding the polypeptides, catalytic domains or carbohydrate binding domains. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic... Agent: Novozymes A/s

20150031092 - Process for pretreatment of the lignocellulosic biomass with a hydrated inorganic salt making it possible to obtain a cellulosic fraction and a hemicellulosic fraction: A method for pretreating lignocellulosic biomass by: a) acid hydrolysis with an acid solution resulting in a liquid fraction and a solid fraction, b) separating the solid fraction and the liquid fraction, c) drying the solid fraction, d) firing the dried solid fraction in a medium comprising at least one... Agent: Ifp Energies Nouvelles

20150031093 - L-aspartate oxidase variant and a method for producing quinolinate or nicotinic acid using the same: To produce quinolinate effectively, a L-aspartate oxidase variant that the feedback regulation by nicotinic acid or NAD is released, and a microorganism including the L-aspartate oxidase variant are provided. Quinolinate may be effectively produced by culturing of the microorganism including the L-aspartate oxidase variant.... Agent:

20150031095 - Enone reductases: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.... Agent:

20150031094 - Polynucleotides encoding engineered ketoreductase polypeptides: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent:

20150031097 - Mobile processing systems and methods for producing biodiesel fuel from waste oils: The present invention improves biodiesel production in several ways. Unique combinations of unit operations and flow configurations are disclosed in mobile processing units that are feedstock-flexible and can be dynamically deployed in a distributed way. In some embodiments, a process includes introducing a waste oil and an alcohol into a... Agent:

20150031096 - Multizymes and their use in making polyunsaturated fatty acids: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding multizymes (i.e., single polypeptides having at least two independent and separable enzymatic activities) along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these multizymes in plants and oleaginous yeast are disclosed.... Agent:

20150031098 - Mutant of propionyl-coa transferase from clostridium propionicum and preparing method for pla or pla copolymer using the same: Provided is a mutant of propionyl-CoA transferase from Clostridium propionicum that can convert lactate into lactyl-CoA with high efficiency in a method of preparing a polylactate (PLA) or PLA copolymer using microorganisms. Unlike conventional propionyl-CoA transferase which is weakly expressed in E. coli, when a mutant of propiony-CoA transferase from... Agent:

20150031099 - Fermentation of gaseous substrates: A reactor system is provided for improved fermentation of a gaseous substrate through the introduction of a secondary loop to a forced-circulation loop reactor. The reactor comprises a primary loop through which fermentation broth comprising a gaseous substrate is circulated through a riser segment and a downcomer section by a... Agent:

20150031101 - Bacterial cell having enhanced succinic acid production and a method for producing the succinic acid using the same: A genetically engineered bacterial cell wherein activity of a pathway in the cell of converting α-ketoglutarate into succinate semialdehyde; or activity of succinyl semialdehyde dehydrogenase in the cell is increased compared to the activity in a non-genetically engineered cell of the same type, and a method of producing succinic acid... Agent:

20150031100 - Compositions and methods for chemical reporter vectors: Embodiments of the present invention concerns methods and compositions for the construction of a series of vectors containing a chemical sensing module to assess the production of a chemical compound by a microorganism.... Agent: The Regents Of The University Of Colorado, A Body Corporate

20150031102 - Methods and compositions for enhanced production of butanol by clostridia: The invention relates generally to methods and compositions for maintaining and manipulating microbial cultures of Gram-positive bacteria. Also provided are methods for identifying quorum sensing regulatory proteins and auto-inducing peptides in Gram-positive bacteria. Also provided are methods and compositions believed to affect quorum sensing pathways of the genus Clostridium to... Agent:

20150031103 - Novel promoter and use thereof: The promoter of the present invention causes a desired gene to be highly expressed, especially in thermotolerant yeast. The promoter is located upstream of the PIR1 gene or the CTR1 gene on the Kluyveromyces marxianus chromosome and comprises a region controlling expression of the PIR1 gene or the CTR1 gene.... Agent: Yamaguchi University

20150031105 - Membrane bioreactor for increased production of isoprene gas: The invention provides improved methods for the production of isoprene from biological materials.... Agent:

20150031104 - System for generating biogas and method for operating such a system: A system for generating biogas comprises at least one fermenter (1) for fermenting solid biomass (13). The fermenter (1) comprises a device for charging the biomass with a liquid medium, a gas outlet (2) for removing the biogas from the fermenter (1) and a gas inlet (3) for supplying gases... Agent:

20150031106 - Hcv protease inhibitors and uses thereof: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.... Agent: Celgene Avilomics Research, Inc.

20150031107 - Pcr reaction mixtures with decreased non-specific activity: The present invention provides methods for improving the specificity of nucleic acid amplification comprising incubating a nucleic acid molecule with a polymerase-Sso7 DNA binding domain conjugate and arginine, spermidine, or spermine. The present invention also provides reaction mixtures and kits for improving the specificity of nucleic acid amplification.... Agent:

20150031108 - Processes for preparing peptide conjugates and linkers: The present invention provides a process for preparing a compound of Formula 5b, as well as intermediates thereof, and novel classes of compounds useful in process for preparing these and similar compounds.... Agent:

20150031109 - Polyol oxidases: The present invention provides compositions and methods for producing a polyol oxidase in micoroorganisms, and the use of polyol oxidases in cleaning compositions. The invention includes cleaning compositions that contain combinations of two or more POx oxidases, and cleaning compositions that contain combinations of two or more POx oxidases and... Agent: Danisco US Inc.

20150031110 - Phytase having improved enzymatic activity: A phytase having improved enzymaic activity is disclosed. The phytase has a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of Valine at position 90 with Threonine. Alternatively, the phytase has a modified amino acid sequence of SEQ ID NO: 6, wherein the... Agent:

20150031111 - Lipase variants and polynucleotides encoding same: The present invention relates to isolated lipase variants, comprising a substitution at one or more positions corresponding to positions I86D,E,N,Q, E87C, I90D,E,Q, and N92D,E,Q of the mature polypeptide of SEQ ID NO: 2, wherein the variant has lipase activity. In some embodiments the present invention relates to isolated polynucleotides encoding... Agent:

20150031112 - Crystal structure of human alpha-n-acetylglucosaminidase: The present invention provides the three-dimensional structure of human α-N-acetylglucosaminidase (NAGLU) protein. This crystallographic information is useful in the identification and development of novel binding compounds of NAGLU, NAGLU mutants, for example, those associated with Sanfilippo syndrome type B (mucopolysaccharidosis III B (MPS III-B)), and other NAGLU family members (family... Agent: Shire Human Genetic Therapies, Inc.

20150031113 - Polypeptides having endoglucanase activity and polynucleotides encoding same: Provided are isolated polypeptides having endoglucanase activity, catalytic domains, cellulose binding domains and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides catalytic domains or cellulose... Agent:

20150031114 - Detergent compositions comprising subtilase variants: The present invention relates to detergent compositions comprising subtilisin variants and methods for obtaining such detergent compositions. The present invention also relates to the use of such detergent compositions, especially in laundry or in hard surface cleaning applications.... Agent:

20150031115 - Expression in insect cells of genes with overlapping open reading frames, methods and compositions therefor: The present teachings disclose nucleic acid cassettes for expressing in an insect cell a plurality of polypeptides encoded by a gene comprising overlapping open reading frames (ORFs). A cassette comprises, in 5′ to 3′ order, a) a first insect cell-operable promoter, b) a 5′ portion of a gene comprising a... Agent:

20150031116 - Integrated active flux microfluidic devices and methods: The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g.,... Agent: California Institute Of Technology

20150031117 - Methods for rapid forensic analysis of mitochondrial dna and characterization of mitochondrial dna heteroplasmy: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.... Agent:

20150031118 - Acoustic mass sensor: A mass sensor has a common RF input, a set of mass sensor cells, and a common hold input. Each of the mass sensor cells has a local input node coupled to the common RF input, a local output node, a mass-dependent RF filter that includes an electroacoustic resonator having... Agent: Avago Technologies GeneralIP(singapore) Pte. Ltd.

20150031119 - Device for early detection of micro-organisms: The device permitting an early detection, without measurement of the fluorescence, of colonies resulting from the multiplication of micro-organisms present in a sample to be tested, includes a substantially flat and horizontal detection surface, on which at least one support for growing the micro-organisms in the form of colonies is... Agent:

20150031120 - Mems particle sorting actuator and method of manufacture: A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located... Agent: Innovative Micro Technology

20150031121 - Sample holding carrier and fluorescence detection device using same: Disclosed is a sample holding carrier allowing samples to be measured accurately, and a fluorescence detection device for use with the sample holding carrier. A biosensor substrate includes a base substrate, a plurality of wells formed on a first surface side of the base substrate; and grooves formed on the... Agent:

20150031122 - Panelized drum system: A rotating drum that is made from a plurality of panels that are connected to form sub-cylinders that, in turn, are connected to form a drum cylinder. Drum heads are connected at both ends of the drum cylinders. The drum may be rotated using rotational means. In one preferred embodiment... Agent:

20150031123 - Composting device: A device for transforming refuse into compost according to a cycle of operation has a cabinet, a hopper, a first reducing mechanism in the hopper, a first heating element coupled to the hopper, a transfer mechanism disposed in a conduit from the hopper to an outlet, a motor beneath the... Agent: Whirlpool Corporation

20150031124 - Separator: The present invention concerns in one aspect a separator for separating the gas and liquid phases of a foam and, in another aspect, a foam reducing apparatus. The separator comprises a first side and a second side and having through-flow means provided therein for permitting a foam or a foam... Agent:

20150031125 - Micro-device and methods for disrupting cells: A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in... Agent:

20150031126 - System and method of taking and collecting tissue cores for treatment: A tissue cutting device that is especially suited for neurosurgical applications is disclosed and described, as well as alternative systems for tissue preservation and transport. The cutting device includes an outer cannula in which a reciprocating inner cannula is disposed. A tissue collector is also provided and is in fluid... Agent:

20150031127 - Self-assembled nanostructures: The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nano structures.... Agent: Northwestern University

20150031128 - Culture medium for eukaryotic cells: The invention pertains to the use of (i) one or more C2-C6 alpha-hydroxy acids, salts of these acids, esters of these acids and combinations thereof; and (ii) one or more compounds selected from—the group of amino acid derivatives consisting of γ-glutamyl amino acids, pyroglutamyl amino acids, glutamate-containing or proline-containing dipeptides,... Agent: Friesland Brands B.v.

20150031129 - Method for proliferating stem cells by activating c-met/hgf signaling and notch signaling: The present invention relates to stem cells in which a gene that activates signaling is introduced and to a method for proliferating the stem cells. More specifically, the invention relates to a method of significantly increasing the ability of stem cells to proliferate, either by transfecting stem cells with the... Agent:

20150031130 - Compounds and methods for enhanced cellular uptake: Described herein are conjugated modified oligonucleotides that are complementary to a target RNA. The conjugate facilitates cellular uptake of the modified oligonucleotide, resulting improved potency.... Agent: Regulus Therapeutics Inc.

20150031131 - Tissue-engineered constructs: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also... Agent:

20150031132 - Genome engineering: Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided.... Agent:

20150031133 - Genome engineering: Methods of genome engineering in cells using a TALEN lacking repeat sequences or Cas9 is provided.... Agent:

20150031134 - Crispr-cas component systems, methods and compositions for sequence manipulation: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are... Agent:

  
01/22/2015 > 128 patent applications in 73 patent subcategories.

20150024374 - Gas exchanger and artificial lung: Blood or other fluids can be caused to interact with a gas by providing a plurality of fluid flow channels that are surrounded by nanotubes, each of the channels having an inflow end and an outflow end, wherein each of the channels is wide enough for the blood to flow... Agent:

20150024373 - Microfluidic chip: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the... Agent:

20150024375 - Reflex testing of samples using residual materials from a prior test: Embodiments disclosed herein relate to methods and systems for performing automated assays, and particularly to performing sequential assays on a sample on an automated instrument.... Agent:

20150024378 - Analysis of dna-containing samples and resolution of mixed contributor dna samples: Methods for analyzing DNA-containing samples are provided. The methods can comprise isolating a single genomic equivalent of DNA from the DNA-containing sample to provide a single isolated DNA molecule. The single isolated DNA molecule can be subjected to amplification conditions in the presence of one or more sets of unique... Agent:

20150024377 - Apparatus comprising magnetically actuated valves and uses thereof: The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In... Agent: Sandia Corporation

20150024382 - Assay methods for mdv-1: A method for the quantification of a vaccine strain and/or a virulent strain of Marek's Disease Virus Serotype-1 (MDV-1) in a sample from a bird, comprising the steps of: (i) providing a biological sample from the bird and optionally isolating nucleic acid from the biological sample; (ii) subjecting the biological... Agent:

20150024383 - Assay methods for mdv-1: A method for the quantification of a vaccine strain and/or a virulent strain of Marek's Disease Virus Serotype-1 (MDV-1) in a sample from a bird, comprising the steps of: (i) providing a biological sample from the bird and optionally isolating nucleic acid from the biological sample; (ii) subjecting the biological... Agent:

20150024381 - Detecting and quantifying cryptic hiv replication: The present invention relates to a novel method for detecting efficient cryptic HIV replication in a patient who receives a suppressive antiviral therapy followed by administration of the HIV integrase inhibitor in an effective amount for intensifying the suppressive antiviral therapy, and has undetectable plasma viremia prior to the administration... Agent: University Of Delaware

20150024379 - Fiber sampler for recovery of bioaerosols and particles: An aerosol collection system and method. The system includes a bio-aerosol delivery device configured to supply bioparticles in a gas stream, a moisture exchange device including a partition member coupled to the gas stream and configured to humidify or dehumidify the bioparticles in the gas stream, and an aerosol collection... Agent: Aerosol Dynamics Inc.

20150024380 - Interfering peptides and method for detecting microorganisms: The invention relates to novel interfering peptides having peptide sequence S with between 7 and 12 amino acids, originating from the peptide sequence of an antigenic protein of a micro-organism M, the sequence S being aligned with a peptide sequence S′ with between 7 and 12 amino acids originating from... Agent:

20150024376 - Trap and flow system and process for capture of target analytes: A magnetizable trap and flow system and process are detailed that uniformly disperse paramagnetic or superparamagnetic analyte capture beads within a scaffold of magnetizable beads or other magnetizable materials in a capture zone that provides selective capture of target analytes. A magnet placed or energized in proximity to the trap... Agent: Battelle Memorial Institute

20150024385 - Prediction of fertility in males: A method for evaluating sperm fertility. The method includes the steps of obtaining a sample of sperm from an animal of a species; staining the sample with a fluorescent DNA-binding dye; collecting at least one image of the stained sample; determining an edge of a nucleus of at least one... Agent:

20150024384 - Sequential delivery device and method: A reagent delivery device includes a reagent delivery column with a housing receiving reagent storage elements that can move, and a breaching element coupled to the housing. The device includes an actuation member that during operation forces the reagent storage elements toward the breaching element. Breaching the storage elements releases... Agent:

20150024396 - Brassica ahas genes and gene alleles that provide resistance to imidazolinone herbicides: Plants, plant parts and plant seeds that are resistant to imidazolinone herbicides are provided. Plants are disclosed that contain a mutation in an AHAS gene. Specifically, plants are disclosed that contain a mutant AHAS gene allele of the Brassica juncea B genome. Two B. juncea AHAS gene sequences (BjAHAS-a and... Agent:

20150024391 - Compositions and methods for detecting allogeneic matter in a subject: The present disclosure provides a panel of nucleic acid molecule primers specific for HLA-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious... Agent:

20150024388 - Expression of sep-like genes for identifying and controlling palm plant shell phenotypes: Methods and compositions are provided for optimizing fruit morphology.... Agent:

20150024390 - Method and kit for detecting specific single nucleotide polymorphism associated with ankylosing spondylitis: Disclosed is a nucleotide fragment of pathogenic single nucleotide polymorphism associated with ankylosing spondylitis with genome-wide correlation analysis of the ankylosing spondylitis patient and healthy control population in large sample by an intensive genome-wide SNP chip, the nucleotide fragment being located at the site of rs17095830, wherein for the ankylosing... Agent:

20150024386 - Method and rapid test for the detection of specific nucleic acid sequences: A universally usable method for specific detection of target nucleic acid sequences, which method can be performed very rapidly and also simply and furthermore which does not need any expensive instrumental systems. The method is intended to be suitable as a molecular genetic rapid test and to respect the requirements... Agent: Aj Innuscreen Gmbh

20150024393 - Method and system for automated image analysis in cancer cells: A method of screening for the presence and/or extent of a pathology in a subject, the pathology characterized by an abnormal chromosomal component in a cell of the subject, comprising the steps of: contacting a biological sample comprising cell nuclei from said subject with, one or more distinguishable labeled probes... Agent: Neodiagnostix Inc

20150024394 - Method and system for automated image analysis in cancer cells: A method of screening for the presence and/or extent of a pathology in a subject, the pathology characterized by an abnormal chromosomal component in a cell of the subject, comprising the steps of: contacting a biological sample comprising cell nuclei from said subject with, one or more distinguishable labeled probes... Agent: Neodiagnostix, Inc.

20150024395 - Method and system for automated image analysis in cancer cells: A method of screening for the presence and/or extent of a pathology in a subject, the pathology characterized by an abnormal chromosomal component in a cell of the subject, comprising the steps of: contacting a biological sample comprising cell nuclei from said subject with, one or more distinguishable labeled probes... Agent:

20150024389 - Method for detecting bladder cancer cells, primer used in method for detecting bladder cancer cells, and bladder cancer marker: Provided are: a method for detecting bladder cancer with high detection sensitivity, which has a high specificity for bladder cancer and is capable of detecting bladder cancer tissues with low grade of malignancy; and a bladder cancer marker. A method for detecting bladder cancer cells, which comprises detection of the... Agent: Lsip, LLC

20150024392 - Method for producing a biosensor: An object of the present invention is to provide a biosensor comprising a hydrogel capable of immobilizing a physiologically active substance thereon, which can be produced conveniently by use of a safe material, and a method for producing the same. The present invention provides a method for producing a biosensor,... Agent: Fujifilm Corporation

20150024387 - Methods for the reduction of stutter in microsatellite amplification: The invention provides a method for reducing stutter in the amplification of a microsatellite comprising the steps of providing a sample comprising a microsatellite having a G+C content of 50% or less; contacting the sample with at least one enzyme having nucleic acid polymerase activity; and incubating the sample with... Agent:

20150024398 - Analysis of genetic biomarkers for forensic analysis and fingerprinting: The present invention relates generally to methods of determining base compositions for PCR products (e.g., RT PCR products, (rt) RT-PCR products, etc.). In particular, the present invention provides base-composition determination of PCR products containing up to five different nucleobases (e.g., A, C, G, T, U) and/or significant levels of non-templated... Agent: Ibis Biosciences, Inc.

20150024401 - Analyzer: An object of the present invention relates to providing a nucleic acid analyzer capable of testing a plurality of test items in parallel, and of obtaining high efficiency of specimen processing even if the test item or a measuring object is changed. The present invention relates to an analyzer including... Agent:

20150024399 - Molecular diagnosis and typing of lung cancer variants: Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. The expression of the gene or biomarker is indicative of the lung tumor subtype. The compositions include subsets of genes... Agent:

20150024397 - Monitoring recombinase polymerase amplification mixtures: A process includes providing a mixture that includes a recombinase, a single-strand binding protein, and one or more oligonucleotides; and detecting particles in the reaction mixture.... Agent: Alere San Diego, Inc.

20150024400 - Sample collection devices, kits and methods of use: Devices, methods, and kits are disclosed for collection, labeling and analysis of samples containing a substance of interest. Such devices and methods are used in forensic, human identification, access and importation control, and other investigative technologies to collect even limited amounts of a substance of interest that may be present... Agent:

20150024402 - Method and kit for measuring interaction between molecules: The present invention relates to methods of measuring interaction between a first and a second molecule, for example a protein and an antibody, by conjugation of one of these molecules with nanoparticles, and measuring the interaction between the first and second molecule via changes in the optical properties of the... Agent:

20150024406 - Increased aquaporin expression on cellular membrane to improve cryopreservation efficiency: A method of storing mammalian cells or tissue (e.g., liver cells or hepatocytes) for subsequent use comprises the steps of: (a) contacting the cells or tissue in vitro to a choleretic agent in an effective amount; (b) combining said cells or tissue with a cryopreservative; (c) freezing said cells or... Agent:

20150024407 - T1r hetero-oligomeric taste receptors: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are... Agent:

20150024408 - Water soluble nanocrystalline quantum dots capable of near infrared emissions: A novel quantum dot capable of near infrared emissions at wavelengths of 750-1100 is made by forming solid solutions of metal sulfide, metal selenide or metal sulfide selenide by incorporating a suitable amount of an additional metallic element or elements to provide an emission wavelength in the range of 750... Agent: Drexel University

20150024409 - Methods and systems for predicting drug-response: Disclosed herein are methods and systems for determining whether a cell is resistant to one or more drugs. Also, disclosed herein are methods and systems for monitoring the treatment of a cancer patient to determine whether the cancerous cells being treated are resistant to the treatment. Further, disclosed herein are... Agent:

20150024411 - Chromatographic isolation of cells and other complex biological materials: The present invention relates to the chromatographic isolation of a target cell or another complex biological material, in particular by column chromatography such as affinity chromatography or gel permeation chromatography. The invention employs a receptor binding reagent that binds to a receptor molecule that is located on the surface of... Agent:

20150024412 - Humanized fcgammar mice: Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low... Agent:

20150024410 - Method for determining the glycosylation of an antibody: The invention relates to a method for detecting the binding of an antibody to an Fc receptor present on the surface of a cell as well as to a method for determining the level of glycosylation of an antibody. The invention also relates to a reagent kit for carrying out... Agent: Cisbio Bioassays

20150024413 - Biomarkers of oxidative stress: The present invention relates to a method for detecting cardiovascular oxidative stress in an individual, comprising detecting in a blood sample from the individual modification of a cysteine at position 45 of the β1-subunit of the human erythrocyte ATP-dependent Na+K+ pump protein or of an equivalent cysteine in a homologue... Agent: Northern Sydney Local Health District

20150024414 - Amplification of biological targets via on-chip culture for biosensing: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded... Agent: Sandia Corporation

20150024403 - Method for detecting replication or colonization of a biological therapeutic: Methods for detecting replication in or colonization of a host by a biological therapeutic, such as an oncolytic virus, cells administered for cell therapy and gene therapy vectors, are provided. In the methods, a product produced by the biological therapeutic is detected in a sample of tissue or body fluid... Agent:

20150024415 - Detection and quantification of analytes based on signal induced by alkaline phosphate: A general methodology for highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method and sensors take advantage of the ability of alkaline phosphatase (ALP) to convert glucose-1-phosphate to glucose,... Agent: The Board Of Trustees Of The University Of Illinois

20150024404 - Assays for the detection of anti-tnf drugs and autoantibodies: The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against... Agent:

20150024405 - Enhanced deposition of chromogens utilizing pyrimidine analogs: where R1, R2, R3, and R4 are independently selected from aliphatic, aryl, halogen, a heteroatom-containing moiety, and hydrogen; R1 and/or R3 can be bound to R2 to form a fused, aromatic ring system; R5 is selected from a heteroatom-containing moiety; A is selected from, a carbon atom, a heteroatom, other... Agent: Ventana Medical Systems, Inc.

20150024416 - Correction method for estimating free light chain production: The invention provides a method of estimating free light chain production (FLC) in a subject comprising (i) determining an amount of FLC in a sample from the subject; and (ii) correcting the amount of FLC in the sample for FLC cleared from the source of the sample by glomerular filtration... Agent: The Binding Site Group Limited

20150024420 - Extracellular and membrane-associated prostate cancer markers: This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring... Agent: Mayo Foundation For Medical Education And Research

20150024418 - Method for diagnosing or prediagnosing a beta-amyloidopathy or an alpha-synucleopathy: The invention relates to a method for the diagnosis or prediagnosis of a β-amyloidopathy or an α-synucleopathy accompanied by a cerebral protein deposit and a reduced activity of the cerebral ABCC1-transporter, or for determining the risk of a proband suffering from such an illness, the proband already having accumulated substances... Agent:

20150024419 - Method for the assay of synucleins: The present invention provides a method for the assay of synucleins in a body fluid or tissue sample, wherein said method comprises the steps of contacting said sample with membrane lipids under conditions enabling binding of the synuclein to said lipids, and the detection of the lipid-bound synuclein by a... Agent:

20150024417 - Peptides, devices, and methods for the detection of ehrlichia antibodies: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions... Agent:

20150024421 - Number of il4 and/or il13 secreting t-cells as a biomarker for allergic diseases: The present invention relates to an in vitro use of a number of IL-4 and/or IL-13 secreting T-cells as a biomarker for diagnosing and/or monitoring an IgE-dependent allergic disease.... Agent:

20150024422 - Method of determination of risk of 2 hour blood glucose equal to or greater than 140 mg/dl: This invention relates to methods for predicting likelihood of a subject having abnormal glucose tolerance based on analyzing a combination of three or more biomarkers relating to specific physiological processes. This invention also relates to methods of accessing insulin sensitivity in a subject based on analyzing a combination of three... Agent:

20150024423 - Programmed surface enhanced spectroscopy particles: Embodiments include types of programmable surface-enhanced spectroscopy (SES) particles (PSPs), including PSP 200 having a SES-active surface 202 and a programmable reporter 206 associated with the SES surface 202 and methods of fabricating and using same. The programmable reporter 206 provides that the PSP 200 will return a controlled but... Agent:

20150024425 - Apparatuses and methods for forming wounds in cell layers: In one embodiment, an apparatus for forming wounds in cell layers includes a base that includes a guide track, and a sliding member adapted to fit within the guide track, the sliding member including a scratching element holder adapted to secure a scratching element in a position in which it... Agent: Board Of Regents, The University Of Texas System

20150024426 - Blood cell counting device and method: A device for use in imaging a liquid sample comprises an inlet for accepting the sample, a connection conduit and a detection chamber for detection of the sample, preferably optical detection of the sample. The connection conduit connects the inlet to the detection chamber and contains one or more dry... Agent:

20150024424 - Engineered living tissue substitute: The present invention relates generally to the field of tissue engineering and in particular to the production of tissue films or cell matrices, which can be used as a living tissue substitute or an artificial tissue construct in tissue repair or replacement.... Agent: National University Of Ireland, Galway

20150024427 - Solution and method for adhering suspension components to a substrate: This disclosure is directed to a method and an attachment solution for adhering a cytological or histological sample, such as buffy coat, to a substrate, such as a microscope slide. The attachment solution includes an attachment base and an anti-coagulant. The attachment base may be an alcohol, an acid, an... Agent: Rarecyte, Inc.

20150024428 - Method of identification of spore-forming bacillus spp. by direct in-situ analysis of maldi-tof mass spectrometry, and analysis system: A method of the identification of Bacillus species by direct in-situ analysis of MALDI-TOF MS (Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectometry) in which spore-forming bacteria are applied intact without any pretreatment, and an analysis system of distinctive biomarkers which allow Bacillus spores to be distinguished. Rapid and accurate detection and... Agent: Agency For Defense Development

20150024429 - Method and device for the homogeneous distribution of suspended cell components: A method for the homogeneous distribution of cell components suspended in a liquid on a surface and a device for the implementation thereof.... Agent:

20150024430 - Method for producing milk protein nanoparticles: The disclosure relates to milk protein nanoparticles produced according to a polymerization method in which at least one protein, which is obtained from milk and which can be thermally plasticized, is plasticized using a plasticizing agent, such as for example, water or glycerol at temperatures between room temperature and 140°... Agent:

20150024431 - Thrombopoietic compounds: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.... Agent: Amgen Inc.

20150024433 - Humanized antibodies that recognize alpha-synuclein: The present application discloses humanized 1H7 antibodies. The antibodies bind to human alpha synuclein and can be used for treatment and diagnosis of Lewy body disease.... Agent: Neotope Biosciences Limited

20150024434 - Method for obtaining fab fragments from single antibody producing cells by multiplexed cpr in combination with taqman probes: Herein is reported a method for a multiplex one tube real-time reverse-transcriptase gene-specific polymerase chain reaction for the amplification and quantification of cognate IgG heavy and light chains encoding nucleic acids (human IgG isotype) from a single cell.... Agent:

20150024432 - Methods for identifying immunobinders of cell-surface antigens: The invention provides methods for identifying immunobinders, such as scFv antibodies, capable of specifically binding to cell surface antigens, and compositions identified according to said methods.... Agent: Esbatech, An Alcon Biomedical Research Unit LLC

20150024435 - Mutated t7 rna polymerases: The present invention pertains to a mutated T7 RNA polymerase and its use, the T7 RNA polymerase being mutated at position 744, the glutamine (Q) being replaced by an amino acid selected from arginine (Q744R), leucine (Q744L) or proline (Q744P).... Agent:

20150024436 - Sample preparation, processing and analysis systems: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic... Agent: Integenx Inc,

20150024437 - Maltitol enriched products: The present invention relates to a process for producing a syrup which is rich in maltitol. The process is comprising the successive steps of liquefaction of a starch milk and saccharification of the liquefied starch milk in the presence of alpha-amylase, beta-amylase and a debranching enzyme selected from the group... Agent: Cargill, Incorporated

20150024438 - Heterologous expression of termite cellulases in yeast: The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast Saccharomyces cerevisiae. The cellulases can also be co-expressed in host cells with other cellulases. The expression in such host cells... Agent: Mascoma Corporation

20150024439 - Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent:

20150024440 - Microorganisms for the production of melatonin: Recombinant microbial cells and methods for producing melatonin and related compounds using such cells are described. More specifically, the recombinant microbial cell may comprise exogenous genes encoding one or more of an L-tryptophan hydroxylase, a 5-hydroxy-L-tryptophan decarboxylyase, a serotonin acetyltransferase, an acetylserotonin O-methyltransferase; an L-tryptophan decarboxy-lyase, and a tryptamine-5-hydroxylase, and... Agent:

20150024442 - Modified diacylglycerol acyltransferase proteins and methods of use thereof: Provided are fusion proteins of diacylglycerol acyltransferase (DGAT) polypeptides fused to at least one heterologous intracellular localization domain, such as a bacterial membrane-targeting domain, modified photosynthetic microorganism that comprise such fusion proteins, and related methods for improving the production of lipids by photosynthetic microorganisms, including lipids such as triglycerides, fatty... Agent: Matrix Genetics, LLC

20150024441 - Peroxisome biogenesis factor protein (pex) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms: Methods of increasing the amount of polyunsaturated fatty acids (PUFAs) in the total lipid fraction and in the oil fraction of PUFA-producing, oleaginous eukaryotes, accomplished by modifying the activity of peroxisome biogenesis factor (Pex) proteins. Disruptions of a chromosomal Pex3 gene, Pex10p gene or Pex16p gene in a PUFA-producing, oleaginous... Agent:

20150024443 - Process for the preparation of ingenol-3-angelate: The invention relates to methods for preparing ingenol-3-angelate from ingenol or ingenol derivatives.... Agent:

20150024445 - Method of producing chemical substance: A method of producing a chemical product by continuous fermentation includes filtering a culture liquid of a microorganism(s) through a separation membrane; retaining unfiltered liquid in, or refluxing unfiltered liquid to, the culture liquid; adding a fermentation feedstock to the culture liquid; and recovering a product in the filtrate, wherein... Agent:

20150024444 - Yeast cell with inactivated nadh dehydrogenase and method of producing lactate using the yeast cell: Provided are a yeast cell in which the activity of an external mitochondrial NADH dehydrogenase is decreased and a method of producing lactate by using the yeast cell.... Agent:

20150024446 - Methods for improving malic acid production in filamentous fungi: The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous... Agent:

20150024447 - Butyraldehyde dehydrogenase mutant, polynucleotide encoding the mutant, vector and microorganism having the polynucleotide, and method of producing 1,4-butanediol using the same: A mutant butyraldehyde dehydrogenase (Bld), a polynucleotide having a nucleotide encoding the mutant, a vector including the polynucleotide, a microorganism including a nucleotide encoding the mutant, and a method of producing 1,4-butanediol using the same.... Agent:

20150024448 - Integrated processes for the conversion of coal to chemicals: Integrated processes are disclosed for the conversion of coal containing mercury compounds, hydrocarbon-containing compounds, sulfur-containing compounds and nitrogen-containing compounds to chemicals in which coal is heated to remove mercury components, pyrolyzed to remove sulfur-containing and nitrogen-containing compounds and then gasified to provide syngas, and syngas is bioconverted to liquid product.... Agent:

20150024449 - Process and medium for reducing selenium levels in biomass from fermentation of co-containing gaseous substrates: A process for fermenting syngas and a fermentation medium provides high ethanol productivity while removing medium components that were previously thought to be essential. The process is effective for providing a specific STY of at least about 1 gram of ethanol/(L·day·gram cells) and for providing a selenium content in cell... Agent: Ineos Bio Sa

20150024450 - Gene knockout mesophilic and thermophilic organisms, and methods of use thereof: One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt... Agent: Mascoma Corporation

20150024451 - Protein recovery: A process for recovering a protein-containing fermentation agent, comprising (i) forming an aqueous mixture of an organic material and a protein-containing fermentation agent capable of fermenting the organic material to produce ethanol, (ii) fermenting the aqueous mixture to produce ethanol, (iii) recovering from the fermented aqueous mixture an ethanol stream... Agent:

20150024452 - Exhaust scrubber: Provided herein are methods, devices and systems for decreasing emissions in exhaust comprising contacting the exhaust with a liquid waste stream from a biogas production unit, the liquid waste stream being contacted with the exhaust, optionally, in a plurality absorbers operatively connected in-line and/or in parallel.... Agent:

20150024453 - Integrated process for dual biocatalytic conversion of co2 gas into bio-products by enzyme enhanced hydration and biological culture: A method, process, apparatus, use and formulation for dual biocatalytic conversion of CO2 containing gas into carbon containing bio-products by enzymatic hydration of CO2 into bicarbonate ions in the presence of carbonic anhydrase and metabolic conversion of the bicarbonate ions into carbon containing bio-products in a biological culture. The dual... Agent:

20150024454 - Oil absorption and bioremediation apparatus employing oil digesting microorganisms: An absorbent material may include banana tree stalk fibers separated and processed for moisture content reduction to generate processed fibers, and oil eating microorganisms (OEMs) infused into the processed fibers to form OEM infused fibers. The processed fibers may be configured to concentrate oil therein responsive to exposure to the... Agent:

20150024457 - Antibodies to troponin i and methods of use thereof: The subject invention relates to antibodies to troponin I as well as methods of use thereof. In particular, such antibodies may be used to detect Troponin I in a patient and may also be used in the diagnosis of, for example, a myocardial infarction or acute coronary syndrome.... Agent:

20150024456 - Compounds and methods for use in detecting gabapentin: Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce gabapentin conjugates. A gabapentin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-gabapentin antibody. A gabapentin-detectable label may be used in a... Agent:

20150024458 - Dock-and-lock (dnl) complexes for therapeutic and diagnostic use: Disclosed herein are methods and compositions dock and lock (DNL) complexes comprising an AD moiety selected from an AKAP protein and a DDD moiety selected from a protein kinase A regulatory subunit. Also disclosed are fusion proteins comprising an AD moiety or DDD moiety attached to an effector moiety. The... Agent:

20150024459 - Multivalent antibody complexes targeting igf-1r show potent toxicity against solid tumors: The present invention concerns methods and compositions comprising an anti-IGF-1R antibody or fragment thereof for treatment of cancer or autoimmune disease. Preferably, the cancer is renal cell carcinoma, breast cancer or pancreatic cancer. The anti-IGF-1R antibody or fragment may be part of a complex, such as a DOCK-AND-LOCK™ (DNL™) complex.... Agent:

20150024460 - Npp1 fusion proteins: The present invention provides a novel fusion polypeptide containing a catalytic domain of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.... Agent:

20150024455 - Nucleophilic catalysts for oxime linkage: The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and... Agent:

20150024461 - Mutant enzyme and application thereof: An object is to provide a novel enzyme that exhibits glucose dehydrogenase activity. Furthermore, another object is to provide a novel method pertaining to enzyme modification. Provided is a mutated enzyme containing an amino acid sequence wherein one or at least two amino acids selected from a group are substituted... Agent:

20150024462 - Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin: The present disclosure relates to improved expanded bed adsorption processes for isolating proteins from milk sources. In particular embodiments, the present disclosure provides a process for isolating a milk protein, such as lactoferrin, from a milk source comprising establishing an expanded bed adsorption column comprising a particulate matrix, applying a... Agent:

20150024463 - Modified polymerases for improved incorporation of nucleotide analogues: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly... Agent: Illumina Cambridge Limited

20150024464 - Engineered nucleases and their uses for nucleic acid assembly: Aspects of the invention provide engineered endonucleases that are characterized by both a long recognition sequence and specific cleavage outside of the recognition site. Engineered endonucleases of the invention are useful for manipulating long pieces of DNA.... Agent: Celexion, LLC

20150024465 - Carbohydrate-binding modules of a new family: The present invention relates to non-catalytic carbohydrate-binding modules (CBM) belonging to a new family of CBM's. A CBM of the invention was found attached to a glycosyl hydrolase family 61 (GH61) polypeptide and was shown to have little homology with known CBM's indicating that it is the first known member... Agent:

20150024466 - Polypeptides with xylanase activity: The present invention relates to polypeptides with xylanase activity and uses thereof. The present invention also relates to method of modifying polypeptides with xylanase activity to affect, preferably to increase, xylanase activity and/or bran solubility.... Agent:

20150024467 - Methods for purification of recombinant aav vectors: Provided herein are methods for the purification of recombinant adeno-associated virus (rAAV) vectors that can be used for gene transfer and specifically for gene therapy or vaccination. Recombinant AAV vectors of the invention are substantially free of in-process impurities, including production components such as cellular nucleic acids, cellular proteins, helper... Agent: Genzyme Corporation

20150024469 - Endolysin obpgplys: The present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO: 1 and fragments or derivatives thereof. The present invention further relates to fusion proteins comprising said polypeptide and an additional peptide stretch fused to said polypeptide at the N- or C-terminus. Moreover, the... Agent: Katholieke Universiteit Leuven, K.u. Leuven R&d

20150024468 - Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol: The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2... Agent: Genomatica, Inc.

20150024470 - Microorganism belonging to yarrowia genus, and oil decomposition agent and oil decomposition/removal method using same: The present invention addresses the problem of providing a new microorganism that is useful for efficiently decomposing oils and fats, and a use for said microorganism. According to screening results, a new Yarrowia lipolytica having a high capacity to assimilate free fatty acids was successfully obtained. Efficient decomposition of oils... Agent:

20150024471 - Enzyme catalyzed disassembly of corn kernels: Whole corn kernels or particles thereof are enzymatically disassembled. The method can produce a solid starch fraction, a solid pericarp fraction, and a liquid fraction. A high purity starch solids product can be provided suitable for use as a feedstock in other chemical processes.... Agent:

20150024472 - Biological growth monitoring and parameter extraction system: A biological growth monitoring and parameter extraction system includes a comparison group platform and an experimental group platform. First environmental sensing modules of the comparison group platform extracts first environmental parameters of a biological comparison area, a first control module transmits the parameters to the experimental group platform, and a... Agent: National Taiwan University

20150024473 - Device and method for performing blood thromboelastographic assays by magnetic sensing: A magnetic sensor elastometry device (MSED) and a method to perform the whole blood thromboelastography assay. It contains key components, including sample cuvette, detecting head, rotating disc, optical motion detector, and etc; and measures viscoelasticity of whole blood samples. The device optically monitors the physical motion of the magnetically driven... Agent:

20150024475 - Affinity capture of circulating biomarkers: Methods, devices and systems for capturing biomarkers are provided. In particular, methods, compositions, and systems that utilize affinity capture devices comprising a processing chamber, affinity capture agent and porous membrane are provided.... Agent:

20150024474 - Thermal cycler device: The present invention relates to a thermal cycler device for carrying reaction slides for assays with thermal cycling reactions. The thermal cycler device includes a conveyer with a plurality of slide holders for conveying slide plates through more than one temperature zones for thermal cycling reactions.... Agent:

20150024477 - Biosensor chip, and biosensor device equipped with same: This biosensor chip is placed in a biosensor device and is rotated while a specimen is measured, the biosensor chip comprising a main body, a holding chamber, a dispensing chamber, a plurality of quantification chambers, and a plurality of measurement chambers. The main body has an inlet into which a... Agent:

20150024476 - Cell sorting system and methods: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of... Agent:

20150024478 - One-way separator for retaining and recirculating cells: The invention relates to the use of single- or multilayer plastic web plates in a sloped channel-type solid material separator with a lamella package.... Agent: Mayer Intellectual Property Gmbh

20150024479 - Thermal cycling apparatus and method for providing thermal uniformity: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.... Agent:

20150024481 - Sample preparation devices and systems: Devices and system for preparing samples are described. Such devices can comprise fluidic chambers, reservoirs, and movable structures for controlling the movement of samples. The device can also comprise functional elements for performing specific operations.... Agent:

20150024480 - System, apparatus and method for material preparation and/or handling: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along... Agent:

20150024482 - Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer: The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is... Agent:

20150024483 - Therapeutic conditioned media: Disclosed are therapeutic compositions useful for treatment of degenerative, autoimmune, inflammatory, and neurological conditions. In one embodiment, clinical conditions are treated by administration of a standardized composition of stem cell, progenitor cell, or cellular supernatant. The invention provides doses of conditioned media that mediate therapeutic effects at concentrations that would... Agent:

20150024484 - Antibody inhibitors of gdf-8 and uses thereof: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.... Agent: Wyeth LLC

20150024485 - Puro-dhfr quadrifunctional marker and its use in protein production: This invention relates to industrial production of proteins. More specifically, the invention relates to the res-DHFR surrogate marker, which corresponds to a fusion between DHFR and a protein conferring resistance to a toxic compound or conferring a metabolic advantage. The invention further relates to the use of res-DHFR for screening... Agent:

20150024486 - Embryonic stem cell specific micrornas promote induced pluripotency: The methods of the present application describe that introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells). These miRNAs did not further enhance reprogramming in the presence of cMyc. Furthermore, unlike previously described methods of generating iPS cells, such as... Agent:

20150024487 - Cryopreservation storage device for cell collection bag, and using method thereof: The present invention relates to a cryopreservative device comprising an outer case, one or more layers of space for the cryo-bags, and two or more Teflon cryopreservative bags. The outer case has a cover lip for opening and closing. The Teflon cryopreservative bags are filled with a freezing resistant. In... Agent: Steminent Biotherapeutics, Inc.

20150024489 - Device for enhancing immunostimulatory capabilities of t-cells: T-cells are generated with enhanced immunostimulatory capabilities for use in self therapy treatment protocols, by utilizing a biodegradable device with a biodegradable support that has one or more agents that are reactive to T-cell surface moieties. The biodegradable devices are mixed with the T-cells sufficiently so that the one or... Agent:

20150024488 - Nucleic acid complex: The present invention relates to a complex comprising a cationic block copolymer and a nucleic acid, the cationic block copolymer having at least a tri-block structure comprising a cationic block and two hydrophilic blocks, or a hydrophilic block and two cationic blocks.... Agent: Commonwealth Scientific And Industrial Research Organisation

20150024490 - Chemically labile peptide-presenting surfaces for cellular self-assembly: Methods of cell culture using patterned SAM arrays are disclosed. Advantageously, the disclosed methods use SAM arrays presenting adhesion peptides to grow confluent monolayers that can invaginate to form an embryoid body.... Agent:

20150024491 - Neuronal culture medium and method for producing in vivo-like and enhanced synaptogenesis neuron model: An object of the present invention is to develop and provide a method for producing a neuron model having reproduced in vivo properties by improving a cell culture medium composition and a cell culture medium composition necessary for the production of such neuron model. According to the present invention, cell... Agent: Okinawa Institute Of Science And Technology Graduate University

20150024492 - Cell expansion system and methods of use: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits... Agent: Terumo Bct, Inc.

20150024494 - Defined cell culturing surfaces and methods of use: a cell culture surface having a film attached thereto, wherein the film includes one or more plasma polymerized monomers; and a coating on the film-coated surface, the coating deposited from a coating solution comprising one or more extracellular matrix proteins and an aqueous solvent, where the total extracellular matrix protein... Agent:

20150024493 - Method for preparing a patterned substrate and use thereof in implants for tissue engineering: A method for preparing a patterned substrate is provided. The method includes melt-spinning at least one biocompatible polymer to form fibers; collecting the fibers on a substrate such that the fibers are aligned on the substrate; and applying a binding agent to the aligned fibers to bond the fibers into... Agent:

20150024495 - Device and method for engineering living tissues: A device for assembling aggregations of adherent cells includes a gripper moveable within an assembly vessel that fixes aggregations of adherent cells at a membrane of the gripper and, by movement of the gripper, assembles aggregations of cells on a separate membrane within the vessel, thereby creating a three-dimensional assembly... Agent:

20150024496 - Methods and systems for utilizing sperm for molecular delivery: Disclosed herein include embodiments related to delivery of molecular molecules by a sperm cell to an egg cell for expression, including transient expression, in a fertilized progeny. Further embodiments relate to computerized systems for assisting in the disclosed methods.... Agent:

20150024497 - Methods and systems for utilizing sperm for molecular delivery: Disclosed herein include embodiments related to delivery of molecular molecules by a sperm cell to an egg cell for expression, including transient expression, in a fertilized progeny. Further embodiments relate to computerized systems for assisting in the disclosed methods.... Agent:

20150024498 - Cldn5 mini-promoters: Isolated polynucleotides comprising a CLDN5 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of... Agent:

20150024500 - Methods and compositions for producing double allele knock outs: The present invention provides a method and compositions utilizing the CRISPR system to disrupt a target gene in eukaryotic cells to produce double allele knock outs. The method finds use in producing afucosylated antibodies with enhanced ADCC activity.... Agent: Larix Bioscience, LLC

20150024499 - Modified cascade ribonucleoproteins and uses thereof: A clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for adaptive antiviral defence (Cascade); the Cascade protein complex comprising at least CRISPR-associated protein subunits Cas7, Cas5 and Cas6 which includes at least one subunit with an additional amino acid sequence possessing nucleic acid or chromatin modifying, visualising, transcription activating or... Agent:

  
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