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Chemistry: molecular biology and microbiology

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
12/18/2014 > 114 patent applications in 63 patent subcategories.

20140370490 - Heart-lung preparation and method of use: An isolated heart or heart-lung preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations of electrode leads, catheters, ablation methods, cardiac implants and other medical devices intended to be used in or... Agent:

20140370491 - Methods for treating a suspension of mononuclear cells to faciiltate extracorporeal photopheresis: A method for performing a photopheresis procedure is provided comprising collecting MNCs in a suspension comprising RBCs and plasma and lysing the red blood cells in the solution, preferably by combining the suspension with a solution to cause lysis. In one example, the solution for causing lysis of the red... Agent:

20140370492 - Liquid reflux high-speed gene amplification device: The present invention provides a liquid reflux reaction control device including an additional mechanism that allows more stable temperature control, a pre-treatment mechanism that performs pre-treatment including a pre-PCR reaction reverse transcription reaction process that allows RNA detection, a melting curve analysis function, chip technology optimal for holding liquid droplets... Agent:

20140370493 - Method for monitoring and controlling cellular growth: The present disclosure is drawn to a device for monitoring and controlling live cells and associated methods. In an example, the device can include a plurality of elongated nanostructures affixed to a substrate. The elongated nanostructures can each have an attachment end and a free end opposite the attachment end.... Agent:

20140370494 - Exogenous internal positive control: The present invention provides an internal positive control for contaminating viruses. The invention provides the use of a second virus as an exogenous internal positive control in methods for verifying the reliability of an assay to detect a first virus, in methods of ensuring the absence of the first virus... Agent: Novartis Ag

20140370497 - Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences: Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. Also provided are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular, provided is a mammalian MPV, subgroups and... Agent:

20140370496 - Oligonucleotide for hiv detection, hiv detection kit, and hiv detection method: The present invention provides an oligonucleotide for HIV detection including a base sequence which is at least 80% identical to a base sequence composed of 10 or more continuous bases in a base sequence represented by SEQ ID NO. 1 or 6, and an HIV detection kit and an HIV... Agent: Japan Science And Technology Agency

20140370495 - Recombinant mycobacteriophages for delivery of nucleic acids of interest into mycobacteria: Methods are provided for detecting mycobacteria in a sample, including clinical samples. Methods are also provided for determining susceptibility of mycobacterial strains to known or potential antibiotic agents, as are kits therefor. Recombinant mycobacteriophages are also provided comprising heterologous nucleic acids of interest.... Agent: University Of Pittsburgh - Of The Commonwealth System Of High Education

20140370498 - Compositions and methods for nucleotide sequencing: The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or... Agent: Illumina, Inc.

20140370499 - Device and method for fragmenting polymers and particles: The invention features devices for fragmenting polymers or particles in a sample using a centrifuge. In its simplest embodiment, the device includes a body and a valve. The valve, to one side of which a sample is applied, is designed to remain closed until a specified centrifugal force is reached... Agent:

20140370500 - Nonviral targeted nanoparticle system for gene transfer and drug delivery: The embodiments herein provide a nanoparticle system for targeted gene delivery or a drug delivery and a method of synthesising the same. The nanoparticle composition for targeted gene transfer and drug delivery comprises a protein, a chitosan and a lipid. A method of synthesizing the nanoparticles involves preparing a gelatine... Agent:

20140370506 - Asymmetric hairpin target capture oligomers: The invention provides an improved stem-loop target capture oligomer and methods of use. Such a target capture oligomer has a target-binding segment forming a loop flanked by stem segments forming a stem. The stem segments are of unequal length. Such probes show little or no binding to immobilized probes in... Agent: Gen-probe Incorporated

20140370501 - Hydrolase enzyme substrates and uses thereof: The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.... Agent:

20140370504 - Method for detecting genetic variation: The present invention relates to a method for detecting genetic variation, comprising the following steps: acquiring reads from a test sample; aligning said reads with a reference genome sequence; dividing said reference genome sequence into windows, calculating the number of said reads which are aligned to each window, and acquiring... Agent: Bgi Diagnosis Co., Ltd.

20140370503 - Method for the diagnosis or prognosis, in vitro, of prostate cancer: The present invention relates to a method for the in vitro diagnosis or prognosis of prostate cancer, which includes a step of detecting at least one expression product of at least one HERV nucleic acid sequence, the use of said nucleic acid sequences, once isolated, as one or more molecular... Agent: Hospices Civils De Lyon

20140370502 - Multilevel analyte assay: The present invention provides methods and devices for detecting the presence of two or more threshold levels of an analyte, including markers of myocardial damage such as cardiac troponins, in a sample. In various embodiments, the invention provides convenient point-of-care tests for determining the condition of a patient, so as... Agent: Nexus Dx, Inc.

20140370507 - Nucleic acid melting analysis with saturation dyes: Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye... Agent:

20140370505 - Saliva-derived measures of telomere abundance and sample collection device: This invention provides devices and methods for sample collection. Devices can include (a) a container having an opening and adapted to receive a liquid sample through the opening; (b) a cover configured to reversibly seal the opening; and (c) a capture device configured to be introduced into the container, wherein... Agent:

20140370508 - A method of preparing biological material: This invention pertains to a method of preparing biological material from a biological sample selected from the group consisting of blood and sputum samples. The method includes the step of altering at least one constitutive characteristic of the biological sample in the presence of a capturing scaffold by adding a... Agent: North-west University

20140370513 - Biological sample collection: Disclosed is a device (10) for collecting a biological sample, the device comprising an elongate handle (40) extending generally along a handle axis, and a sample collecting head (20) removably supported or supportable on the handle, the head being formed from a porous folded planar or sheet material, optionally including... Agent: Ge Healthcare Uk Limited

20140370511 - Chip device for manipulating object component, and method using the same: A chip device for manipulating an object component is described, in which multiple liquid substances such as reagents required for a series of manipulations on a sample are stably secured in separated states throughout the manipulations within the device. The chip device includes a manipulation chip, magnetic particles, and a... Agent:

20140370514 - Endonucleases: The present invention provides an endonuclease I or enzymatically active fragment thereof wherein said endonuclease I has the sequence of SEQ ID No. 4 or a sequence which is at least 70% identical thereto and wherein the amino acid residue which is immediately N-terminal of the FYCGC pentapeptide motif has... Agent: Biotec Pharmaconb Asa

20140370512 - Method for detecting a methicillin resistant coagulase positive staphylococcus aureus strain: The invention relates to a method for detection of a methicillin resistant coagulase positive Staphylococcus aureus (MRSA) strain by means of a sequence specific amplification reaction.... Agent:

20140370509 - Method for quantitative optical measurements and laboratory apparatus: The invention is related to a method for the quantitative optical measurement of a characteristic property of at least one analyte in at least one laboratory sample, in particular for the fluorescence measurement of at least one biochemical or biological sample, has the method using a laboratory apparatus, which h... Agent:

20140370515 - Method of co-culturing human endometrial stem cells and rat embryonic tooth bud cells to obtain ameloblast cells: The various embodiments herein provide a method of co-culturing human endometrial stem cells and rat embryonic tooth bud cells to obtain ameloblast cells. The human endometrial stem cells are isolated from human females between the ages of 18-40 and cultured. The hEnSCs are identified using flowcytometry. The rat embryonic tooth... Agent:

20140370510 - Modulation of peptidome using histone deacetylase inhibitor: Provided herein is a method of modulating an APC peptidome comprising identifying an APC or an APC cell population that expresses an HDACi-associated polypeptide and administering an HDACi to the APC. Also provided herein is a method of identifying an HDACi-associated peptide comprising administering an HDACi to an APC, isolating... Agent: University Of South Florida (a Florida Non-profit Corporation)

20140370516 - Diagnosis of tuberculosis: The invention comprises an oligonucleotide selected from the group comprising SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3; SEQ ID NO: 4; SEQ ID NO: 5 and SEQ ID NO: 6. The invention also comprises a complementary oligonucleotide of the oligonucleotide selected from the group comprising... Agent: Csir

20140370517 - Modular compositing-multiple lot screening protocols for detection of pathogens, microbial contaminants and/or constituents: Particular aspects provide a method of sampling, testing and validating test lots (e.g., single-unit production lots), comprising: assembling a plurality of product portions from each of a plurality of test lots and combining the collected product portions to provide a corresponding set of test lot samples (wherein each test lot... Agent:

20140370518 - Method for detecting risk of alzheimer's disease: The present invention provides a method for detecting the risk of Alzheimer's disease, comprising detecting immunomagnetic reduction signals of two biological markers in a biological sample from a subject, wherein the two biological markers is tau protein and Aβ-42 protein, respectively; and calculating concentrations of the above two biological markers... Agent: Magqu Co. Ltd.

20140370519 - Universal sample preparation system and use in an integrated analysis system: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.... Agent: Integenx Inc.

20140370522 - Detection of protein translocation by beta-galactosidase reporter fragment complementation: Methods and compositions are provided for detecting molecular translocations, particularly protein translocations within and between sub-cellular compartments, using at least two components that exhibit a localization-dependent difference in complementation activity. In particular, alpha-complementing β-galactosidase fragments are provided. These β-galactosidase reporter fragments display significantly enhanced enzymatic activity when one fragment is... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20140370523 - Methods of determining patient response by measurement of her-2 expression: Methods are provided for determining or otherwise assessing the response of a patient to treatment, in particular, to cancer treatment. The methods include the analysis of samples for the presence or the absence of HER2 markers alone or in conjunction with other biomarkers, such as HER3 markers. In certain examples,... Agent: Laboratory Corporation Of America Holdings

20140370524 - Method for producing an examination reagent and kit for analysing a t-cell frequency: A method for producing an examination reagent includes adding a helper ligand to an unfolded receptor protein in an initial solution so as to provide a pre-solution of the examination reagent with a folded receptor protein. The folded receptor protein comprises a bonded helper ligand which can be exchanged with... Agent:

20140370525 - Alpha-hemoglobin stabilizing protein antibodies and methods of use thereof: Methods for detecting and/or imaging erythrocyte precursor cells are provided.... Agent: The Children's Hospital Of Philadelphia

20140370521 - Identification of two novel biomarkers for niemann-pick disease type c: This invention provides novel biomarkers for Niemann-Pick disease, type C (NPC). In an exemplary embodiment, the invention provides methods for identifying a subject as having NPC. In embodiments, the methods involve detecting the level of biomarker selected from the group comprising i) galectin-3 (LGALS3); ii) cathepsin D (CTSD); iii) LGALS3... Agent:

20140370520 - Methods and compounds for detecting cancer: i

20140370526 - Detecting inclusion body myositis: Methods, devices, kits and systems for diagnosing inclusion body myositis (IBM) are provided. Methods, devices, kits and systems involves detecting the presence and/or level of autoantibodies that are reactive against at least a ˜43 kilodalton (kDa) protein or ˜43 kDa protein band from a muscle lysate or a mammalian cell... Agent: The Brigham And Women's Hospital, Inc.

20140370530 - Lasp-1, a novel urinary marker for transitional cell carcinoma detection: The invention relates to the use of LASP-1 in a urine sample obtained from a subject for diagnosing and/or grading transitional cell carcinoma. The invention furthermore relates to a method for diagnosing transitional cell carcinoma comprising detecting the presence or absence of LASP-1 in a urine sample obtained from a... Agent: Julius-maximilians-universit&#xc4 T W&#xdc Rzburg

20140370527 - Method and tool for predicting cancer and other diseases: The invention concerns a marker for low-grade inflammation and metabolic syndrome (MS) and MS-related diseases and/or low-grade inflammation-related diseases such as cardiovascular disease, ischemic heart disease and type 2 diabetes. More particularly it concerns the measurement of the concentration of soluble urokinase plasminogen activator receptor (suPAR) in human biological fluids... Agent:

20140370529 - Method for diagnosing alzheimer's disease: The present invention relates to a method for diagnosing a neurodegenerative disease in a subject, wherein the level of each of at least two catecholamines is measured in a sample of biological fluid from said subject.... Agent: Universite Paris- Sud 11

20140370531 - Method of diagnosing mild traumatic brain injury: The present invention relates to a method of determining whether a subject has suffered a mild traumatic brain injury. The method comprises selecting a subject exposed to a head trauma and determining an apoA-1 level in a body fluid sample obtained from the selected subject, wherein a decreased apoA-1 level... Agent: University Of Rochester

20140370528 - Proteasome deubiquinating inhibitor screening: A method for screening a compound to determine whether the compound is a proteasome deubiquinating inhibitor of high specificity comprises contacting the compound with human 19S regulatory particles (19S RP) of 26S proteasome and determining whether the compound inhibits activity of deubiquinating (DUB) enzymes UCHL5 and USP14; inhibition of UCHL5... Agent: Vivolux Ab

20140370533 - Method of detecting active tb: A method of detecting active TB in a patient comprising providing at least one peptide comprising an amino acid sequence with at least 80% sequence identity to a sequence selected from SEQ. ID NOS. 1 to 8, or an antigenic fragment thereof and contacting the peptide with a biological sample... Agent: Norwegian Institute Of Public Health

20140370532 - Quantitative multiplex detection of pathogen biomarkers: The present invention addresses the simultaneous detection and quantitative measurement of multiple biomolecules, e.g., pathogen biomarkers through either a sandwich assay approach or a lipid insertion approach. The invention can further employ a multichannel, structure with multi-sensor elements per channel.... Agent: Los Alamos National Security, LLC

20140370534 - Apparatus and method for processing sample using microwave: An apparatus for processing a sample using microwaves comprises: a reaction vessel comprising a chamber which accommodates a refrigerant and a sample and an injection port through which a gas is injected; a microwave source which irradiates microwaves into the chamber; a connector which carries the gas injected through the... Agent: Asta Co., Ltd.

20140370535 - Sterility indicating biological compositions, articles and methods: A sterility indicating composition comprising a plurality of sterilization process resistant spores which contain an active protease during germination and initial outgrowth of the spores; and a germination medium comprising at least one labeled protease substrate and at least one nutrient for germination of the spores; wherein the medium is... Agent:

20140370536 - Assemblies and methods for reducing optical crosstalk in particle processing systems: The present disclosure relates to optical crosstalk reduction in particle processing (e.g., cytometry including flow cytometry using microfluidic based sorters, drop formation based sorters, and/or cell purification) systems and methods in order to improve performance. More particularly, the present disclosure relates to assemblies, systems and methods for minimizing optical crosstalk... Agent: Cytonome/st, LLC

20140370538 - Biocompatible method of functionalising substrates with inert surfaces: Biocompatible methods of functionalising inert surfaces for use in biological applications are described. The methods employ the use of synthetic constructs of the generic structure F-S-L (where F is a functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a... Agent:

20140370539 - Hemolysis reagent composition for hemoglobin a1c quantitative analysis using enzymatic method: Disclosed is a hemolysis reagent composition for the quantitative analysis of glycated hemoglobin (HbAlc) via an enzymatic method. The hemolysis reagent compositions of the present invention containing a zwitterionic surfactant and a nitrous compound considerably accelerate hemolysis rate due to the presence of the zwitterionic surfactant, and also induce the... Agent: I-sens,inc. A Corporation

20140370537 - Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells: The present invention provides a method of producing a skeletal muscle cell from a pluripotent stem cell, which includes a step of expressing one or more exogenous factors selected from MyoD, Myf5 and nucleic acids encoding them on a pluripotent stem cell.... Agent: Kyoto Universtiy

20140370540 - Methods for observing samples and preprocessing thereof: Disclosed is a method for enabling flexibility of the exoskeletons or joints of aquatic organisms immersed in an ion liquid water solution to be maintained without destroying their original forms by reducing the difference in osmotic pressure between the inside and outside of the aquatic organisms, preventing dehydration of biological... Agent:

20140370541 - Cell culture liquid/gas-phase chamber devices and related methods, and exemplary use for measuring accumulation of gas-phase nitric oxide in differentiated cultures of normal and cystic fibrosis airway epithelial cells: Embodiments disclosed herein include cell culture liquid/gas-phase chamber devices and related methods that allow measurement of gas-phase components and their production rate as well as substances/mediators released into media by cultured cells in response to various stimuli. In embodiments disclosed herein, these chamber devices are cell culture liquid/gas-phase chamber devices.... Agent: University Of North Carolina

20140370542 - Apparatus and method for detecting and identifying microorganisms: The present invention is an apparatus for detecting the presence, quantity and identity of one or more microorganisms in a sample and a method for using the same. The apparatus is composed of one or more chambers and a sensing element for sensing microorganisms. In particular embodiments, the sensing element... Agent:

20140370543 - Expression process: A process for the production of a target recombinant polypeptide is provided. The process comprises expressing an expression cassette encoding the target polypeptide and co-expressing an expression cassette encoding a mitochondrial foldase. Preferred mitochondrial foldases include Mia 40 and Erv1, and homologs thereof.... Agent: Fujifilm Diosynth Biotechnologies Uk Limited

20140370544 - Methods for identifying sequence motifs, and applications thereof: The present invention relates to methods and algorithms that can be used to identify sequence motifs that are either under- or over-represented in a given nucleotide sequence as compared to the frequency of those sequences that would be expected to occur by chance, or that are either under- or over-represented... Agent:

20140370545 - Reengineering mrna primary structure for enhanced protein production: Described herein are rules to modify natural mRNAs or to engineer synthetic mRNAs to increase their translation efficiencies. These rules describe modifications to mRNA coding and 3′ UTR sequences intended to enhance protein synthesis by: 1) decreasing ribosomal diversion via AUG or non-canonical initiation codons in coding sequences, and/or 2)... Agent:

20140370546 - Protease deficient filamentous fungal cells and methods of use thereof: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.... Agent:

20140370548 - Antibodies immunoreactive with heregulin-coupled her3: Recombinant materials and methods for producing antibodies that specifically bind heregulin-coupled HER3, at a site distinct from the heregulin binding site, are described. These antibodies are particularly useful in treating cancer that expresses HER3.... Agent:

20140370547 - Expression vector organization, novel production cell generation methods and their use for the recombinant production of polypeptides: Herein is reported an expression vector comprising—an antibody light chain expression cassette,—an antibody heavy chain expression cassette, and—a selection marker expression cassette, wherein the expression cassettes are arranged unidirectional, and wherein the expression cassettes are arranged in the 5′ to 3′ sequence of antibody heavy chain expression cassette, antibody light... Agent:

20140370549 - Method for producing scyllo-inositol: The disclosure provides a method of producing a scyllo-inositol or a new scyllo-inositol derivative in a one-step process, from ubiquitous and inexpensive raw materials. Also provided is a scyllo-inositol derivative bonded to saccharides such as glucose and similar.... Agent: Asahi Kasei Chemicals Corporation

20140370550 - Methods for amplifying nucleic acid using tag-mediated displacement: Disclosed are methods for amplifying a nucleic acid target region using an amplification oligomer comprising a target-binding segment and a heterologous displacer tag situated 5′ to the target-binding segment. Initiation of an amplification reaction from the tagged amplification oligomer produces an amplicon comprising the displacer tag, such that once the... Agent:

20140370552 - Endoglucanase 1b (eg1b) variants: The present invention provides endoglucanase 1b (EG1b) variants suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce EG1b variants, as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms,... Agent:

20140370553 - Enzymes for starch processing: The present invention relates to polypeptides comprising a carbohydrate-binding module amino acid sequence and an alpha-amylase amino acid sequence as well as to the application of such polypeptides.... Agent:

20140370551 - Production of sugars and co-products from cellulosic waste streams: This disclosure provides a business method and system for generating sugars and recycling a non-biomass component from a waste stream. In some embodiments, a waste stream comprising cellulose and a non-biomass component is saccharified to produce glucose, followed by recovery of the glucose and non-biomass component, which may be recycled... Agent:

20140370554 - Novel mutant l-arabitol dehydrogenase derived from neurospora crassa with enhanced activity: The present invention is to enhance the stability and enzyme activity of an L-arabitol dehydrogenase derived from Neurospora crassa using techniques from quantum mechanics and molecular mechanics and partial mutation techniques. More specifically, the present invention relates to a method for preparing an L-arabitol dehydrogenase in which a residue which... Agent:

20140370555 - Method for preparing (r)-praziquantel: The invention relates to a new method for preparing (R)-praziquantel. In the invention, by taking advantage of the high stereo selectivity, site selectivity and region selectivity of an enzyme, an intermediate of a pure optical and chiral (R)-praziquantel are obtained by means of the dynamic kinetic resolution of an enantiomer... Agent:

20140370556 - Method for preparing (r)-praziquantel: The invention relates to a new method for preparing (R)-praziquantel. In the invention, by taking advantage of the high stereo selectivity, site selectivity and region selectivity of an enzyme, an intermediate of a pure optical and chiral (R)-praziquantel are obtained by means of the dynamic kinetic resolution of an enantiomer... Agent:

20140370557 - Genetically engineered microbes and methods for producing 4-hydroxycoumarin: Provided herein are methods for the biosynthesis of 4-hydroxycoumarin. In one embodiment, provided herein are genetically engineered microbes that include a metabolic pathway for the production of 4-hydroxycoumarin. Also provided are methods for using the genetically engineered microbes to produce 4-hydroxycoumarin, and using the 4-hydroxycoumarin as the starting point for... Agent:

20140370558 - Modifying soybean oil composition through targeted knockout of the fad2-1a/1b genes: Materials and methods are provided for making soybean varieties that have altered oil composition as a result of mutations in the FAD2-1A and FAD2-1B genes.... Agent: Cellectis

20140370559 - Fermentation of waste gases: The invention relates to the microbial fermentation of gaseous substrates to produce one or more products. The invention relates to the microbial fermentation of a gaseous substrate derived from the conversion of a biogas stream. The invention relates to the conversion of a biogas stream comprising methane to a gaseous... Agent: Lanzatech New Zealand Limited

20140370560 - Bacterial production of methyl ketones: The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces β-ketoacyl-CoAs through a re-engineered β-oxidation pathway and overexpresses FadM.... Agent:

20140370561 - Genetically modified clostridium thermocellum engineered to ferment xylose: One aspect of the invention relates to industrial bioconversion of the xylose portion of biomass materials into fuels and chemicals. Another aspect of the invention relates to industrial bioconversion of the xylan portion of biomass materials into fuels and chemicals. In one embodiment, the invention is directed to the bacterium... Agent: Mascoma Corporation

20140370562 - Production of beta-phellandrene using genetically engineered cyanobacteria: The present invention provides methods and compositions for producing β-phellandrene hydrocarbons from cyanobacteria.... Agent:

20140370563 - Compositions and methods for the relief of inhibition of aldehyde decarbonylase: The present invention is related to compositions and methods for enhanced synthesis of hydrocarbons, particularly, but not limited to, alkanes. The invention, in one embodiment, utilizes the co-expression of a hydrogen peroxide metabolizing enzyme in the presence of an aldehyde decarbonylase enzyme to relieve hydrogen peroxide inhibition of the aldehyde... Agent: Brookhaven Science Associates, LLC

20140370564 - Modified microorganisms and methods of making butadiene using same: The present disclosure generally relates to microorganisms that comprise one or more polynucleotides coding for enzymes in one or more pathways that catalyze a conversion of a fermentable carbon source to butadiene. Also provided are methods of using the microorganisms in industrial processes including, for use in the production of... Agent:

20140370565 - Production of 1,3-dienes by enzymatic conversion of 3-hydroxyalk-4-enoates and/or 3-phosphonoxyalk-4-enoates: The present invention relates to a method for generating 1,3-diene compounds through a biological process. More specifically, the invention relates to a method for producing 1,3-diene compounds (for example butadiene or isoprene) from molecules of the 3-hydroxyalk-4-enoate type or from 3-phosphonoxyalk-4-enoates.... Agent:

20140370566 - High-nitrogen loading for ammonia processing via anaerobic digestion: A method and system to improve in vitro anaerobic digestion processes are disclosed. Simultaneous digestion of dairy manures with various food wastes improves anaerobic process stability and methane production. Co-digestion with blood meal and sweet clover (“BMSC”) at the proper concentrations improves nutrient balance and digestion, biogas production, gives more... Agent:

20140370567 - Dual-functional nonfouling surfaces comprising target binding partner covalently coupled to polymer attached to substrate: Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that... Agent: University Of Washington

20140370568 - Specialized (iso)eugenol-4-o-methyltransferases (s-iemts) and methods of making and using the same: Specialized (iso)eugenol 4-O-methyltransferase (s-IEMT) enzymes having increased capacity for methylation of monolignols are disclosed. The s-IEMTs have unique activity favoring methylation of coniferyl alcohol versus sinapyl alcohol. Various s-IEMTs methylate ferulic acid. Means for producing the various s-IEMTs are provided. The s-IEMTs are useful for modification of lignin content and... Agent:

20140370569 - Expression method: In a microbial fermentation, the aim is to increase the product yield of protein. This is achieved by a method in which an expression construct is introduced into a microorganism of the species Bacillus pumilus which comprises a promoter and a nucleic acid coding for the protein, and the protein... Agent: Basf Se

20140370570 - Use of a cysteine protease of plasmodium vivax: A use of vivapain-4 (VX-4), which is a cysteine protease of Plasmodium vivax, showing pH-dependent switching of substrate specificity, is provided. More specifically, a method of treating a parasitic disease caused by Plasmodium vivax by inhibiting VX-4; a method of screening a protease inhibitor acting on VX-4, wherein the protease... Agent:

20140370572 - Means and methods of increasing viability of rod-shaped bacteria: This invention relates to use of peptone for controlling the volume and/or the length-to-diameter ratio of cells in culture, wherein said cells are cells of rod-shaped probiotic bacteria or rod-shaped fermentation bacteria.... Agent:

20140370571 - Versatile extremely thermophilic bacteria for the conversion of biomass: The present technology pertains to novel isolated xylanolytic, amylolytic and saccharolytic thermophilic bacterial cells belonging to the genus Thermoanaerobacter, isolated strains, microbial cultures, compositions comprising said cells and their use in the conversion of lignocelluslosic biomass.... Agent: Direvo Industrial Biotechnology Gmbh

20140370573 - Method for producing isopropanol and recombinant yeast capable of producing isopropanol: Isopropanol is produced with good productivity via fermentation processes. Specifically, isopropanol is produced at a high level in a medium by culturing recombinant yeast into which an acetoacetyl CoA synthase gene and a group of genes (isopropanol synthesis-related gene group) encoding a group of enzymes for synthesis of isopropanol from... Agent: Toyota Jidosha Kabushiki Kaisha

20140370575 - Genetically enhanced cyanobacteria for the production of a first chemical compound harbouring zn2+, co2+ or ni2+ -inducible promoters: One embodiment of the invention is directed to a genetically enhanced cyanobacterium for the production of a first chemical compound, comprising at least one first recombinant gene encoding a first biocatalyst for the production of the first chemical compound, wherein the gene is under the transcriptional control of a Co2+... Agent: Algenol Biofuels Inc.

20140370574 - Metabolically enhanced cyanobacterial cell for the production of ethanol: A metabolically enhanced cyanobacterial cell for the production of ethanol is provided. The metabolically enhanced cyanobacterial cell for the production of ethanol comprises at least one recombinant gene encoding a pyruvate decarboxylase enzyme (Pdc) converting pyruvate to acetaldehyde, and at least one recombinant gene encoding a first Zn2+ dependent alcohol... Agent:

20140370576 - Capture of carbon dioxide (co2) from air: Disclosed is a method for removing carbon dioxide from a gas stream, comprising placing the gas stream in contact with a resin, wetting the resin with water, collecting water vapor and carbon dioxide from the resin, and separating the carbon dioxide from the water vapor. The resin may be placed... Agent: Kilimanjaro Energy, Inc.

20140370577 - Dry scrubber system with bacteria: Implementations disclosed herein provide a scrubber system for the reduction and removal of acid gas from a gas stream. The scrubber system includes a dry chemical scrubber having an amount of bacteria therein. A gas stream containing an acid gas contaminant such as H2S is directed into and treated by... Agent:

20140370578 - Modified ceramsite packing useful for biomembrane trickling filter and a process for removing so2 from flue gas using the trickling filter: A process of removing SO2 from a flue gas with a trickling filter using modified ceramsite packing is described. The biological flue gas desulfurization process includes: feeding the flue gas containing sulfur dioxide through the column bottom into the biomembrane trickling filter at certain temperature, contacting with the modified ceramsite... Agent: Research Institute Of Nanjing Chemical Industrial Group

20140370579 - Dandelion processes, compositions and products: Dandelion processes, compositions and products are provided. One process is a method of preparing dandelion that utilizes a species of a Taraxacum genus, the process including the steps of extracting and recovering a rubber and a carbohydrate from a dandelion root substantially simultaneously. The process employs a dandelion species that... Agent:

20140370581 - Microfluidic devices for fluid manipulation and analysis: The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare... Agent: Micronics, Inc.

20140370582 - System and method for determining individualized medical intervention for a disease state: A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample from the patient, determining whether any molecular findings including one or more genes, one or more gene expressed proteins, one or more molecular... Agent:

20140370580 - Unitary biochip providing sample-in to results-out processing and methods of manufacture: A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating... Agent: Netbio, Inc.

20140370583 - Multi-fluidic cartridges for sample analysis and methods for using same: The invention is directed to multi-fluidic cartridges for sample analysis and to methods of using said cartridges. In one embodiment, the cartridge comprises: (a) a first conduit beginning at a sample entry port for receiving a fluid sample and in fluid communication with one or more sensors; (b) a plurality... Agent:

20140370585 - Environmental sampling articles and methods: The present invention refers to articles for collecting samples from a surface, articles for microbiological analyses of said samples, and methods of use of said articles. The articles include sample collectors, sample housings with optional barrier layers, and sample-ready reagent strips comprising hydrophilic agents to grow and detect microorganisms. The... Agent: 3m Innovative Properties Company

20140370584 - Sensor device: A sensor device includes a flow path and a metal layer disposed in the flow path. The flow path is configured to allow a sample containing analytes to flow and to allow a carrier to be disposed therein. The carrier has acceptors that are fixed on a surface thereof and... Agent:

20140370586 - Microchip and microchip-type fine-particle measuring device: A microchip is provided. The microchip includes an incident surface configured to receive light transmitted from a light source, the light being received from an incident direction and a back surface that is opposite the incident surface, the back surface including a portion that is configured to reflect light transmitted... Agent:

20140370587 - Integrated system for hydrogen and methane production from industrial organic wastes and biomass: The present invention provides a system that has been devised to overcome the two most important limitations for sustained biological hydrogen production, namely contamination of the microbial hydrogen-producing cultures with methane-producing cultures necessitating frequent re-start-up and/or other methanogenic bacteria inactivation techniques, and the low bacterial yield of hydrogen-producers culminating in... Agent:

20140370588 - Filtration apparatus for continuous perfusion: In one aspect, an apparatus for bioprocessing using a liquid comprises an at least partially flexible vessel for receiving the liquid, and a filter adapted for moving within the liquid. An agitator may also be provided for agitating the liquid, and may be connected to the mixer. The mixer may... Agent:

20140370589 - Subject selection device and subject selection method: A suction tip includes a tip opening, a tubular passage provided with a first selector configured to permit the passage of non-selection subjects included in a collection of subjects sucked through the tip opening, and a capture portion provided on a side of the tubular passage downstream of the first... Agent: Yamaha Hatsudoki Kabushiki Kaisha

20140370590 - Purification of nucleic acids: The present invention solves the problem of isolating nucleic acids from cells in the presence of the growth medium. The invention is particularly useful for isolating extrachromosomal replicons such as plasmids. Cells are lysed in the presence of the medium in which they were grown and nucleic acids are isolated... Agent:

20140370591 - Brown fat cell compositions and methods: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods... Agent: Biorestorative Ttherapies, Inc.

20140370593 - Flow chamber assembly and methods of using the same: A flow chamber assembly for subjecting cells or other biological reagents to laminar flow conditions and methods of using the flow chamber assembly are provided herein. The flow chamber assembly includes a bottom plate having at least one well with a bottom surface adapted to receive the cells or biological... Agent: Duke University

20140370592 - System for separating a cell sample by centrifugation and column chromatography while maintaining sterility: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so... Agent: Miltenyi Biotech Gmbh

20140370594 - Biological conversion of biomass-derived sugars to value added chemicals: A method of growing a microorganism by culturing the microorganism in a an aqueous solution of carbohydrates containing C6-sugar monomers or C5-sugar monomers, wherein the aqueous solution of carbohydrates is made by reacting biomass or a biomass-derived reactant with a solvent system including a lactone and water, and an acid... Agent: Wisconsin Alumni Research Foundation

20140370595 - Use of synthetic scaffolds for the production of biosynthetic pathway products: The present invention provides methods of producing a product or product precursor of a biosynthetic pathway in a genetically modified host cell. The present invention also provides genetically modified host cells comprising nucleic acids encoding a scaffold polypeptide and nucleic acids comprising nucleotide sequences encoding two or more enzymes in... Agent:

20140370596 - Neural stem cells: A homogenous, symmetrically dividing population of adherent neural stem cells is obtained from ES cells or foetal or adult brain isolates, using an activator of a signalling pathway downstream of a receptor of the EGF receptor family, optionally in combination with an activator of a signalling pathway downstream of an... Agent:

20140370598 - Articles and methods for stem cell differentiation: Articles and methods for stem cell differentiation are generally described. In some embodiments, an article for stem cell differentiation may comprise an oxygen permeable substrate having at least a portion of a surface coated with a matrix. The matrix may allow the surface chemistry of the substrate to be altered,... Agent: Massachusetts Institute Of Technology

20140370597 - Rna interference for the treatment of gain-of-function disorders: The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.... Agent: University Of Massachusetts

20140370599 - Method for preparing biological tissues for use in biological prostheses: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with... Agent:

20140370600 - Method of preparing mesenchymal stem cell basic culturing medium, making of cellular therapy product with mesenchymal stem cell basic culturing medium, and the differentiated one by using the medium: Disclosed is a basic culture medium for mesenchymal stem cells, and a cell therapeutic agent cultured and differentiated using same. The basic culture medium reduces the time taken from collection to mass culturing by increasing the proliferation rate of undifferentiated mesenchymal stem cells derived from an adult tissue such as... Agent: Sewon Cellontech Co., Ltd.

20140370601 - Compositions and methods for enhancing the pluripotency of stem cells: Described herein is the finding that increasing the frequency of Zscan4 activation in mouse ES cells not only enhances, but also maintains their developmental potency in long-term cell culture. Particularly disclosed herein is the finding that the constitutive presence of Zscan4-ERT2, even in the absence of its usual activator tamoxifen,... Agent:

20140370602 - Trophectodermal cell-specific gene transfer methods: The present inventors discovered that genes could be introduced specifically into trophectodermal cells with high efficiency, by infecting blastocysts with viral vectors carrying an arbitrary polynucleotide, or by using a nucleic acid transfection reagent in blastocysts, from which zona pellucida (extracellular matrix covering preimplantation early embryos to protect them from... Agent: Fuso Pharmaceutical Industries, Ltd.

20140370603 - Transgenic cells with increased plastoquinone levels and methods of use: Disclosed herein are transgenic cells expressing a heterologous nucleic acid encoding a prephenate dehydrogenase (PDH) protein, a heterologous nucleic acid encoding a homogentisate solanesyl transferase (HST) protein, a heterologous nucleic acid encoding a deoxyxylulose phosphate synthase (DXS) protein, or a combination of two or more thereof. In particular examples, the... Agent: Los Alamos National Security, LLC

12/11/2014 > 88 patent applications in 57 patent subcategories.

20140363805 - Apparatus and methods for manipulation and optimization of biological systems: A method for optimization of a response of a biological system includes: (1) obtaining measurements of a biological system in response to varying concentrations of drugs in a drug combination; (2) fitting the measurements into a model of the biological system; and (3) using the model of the biological system,... Agent: The Regents Of The University Of California

20140363806 - Bio-electro reactors with real-time adjustable electric parameters and sequencing programmable power supplies: Bio-electro reactors with real-time adjustable electric parameters and sequencing programmable power supplies are disclosed. According to an aspect, a bio-electro reactor for control of electrolysis gases bubbles within a biologically-active substance includes a vessel defining an interior for holding a biologically-active substance. The bio-electro reactor also includes electrodes positioned to... Agent:

20140363808 - Aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method: Provided is aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method, and more particularly, a new GO-SELEX method without target immobilization in which a single-stranded nucleic acid pool may react with a non-bound target material or a counter-target material, after which a single-stranded... Agent: Korea University Research And Business Foundation

20140363809 - Compositions and methods for detecting certain flaviviruses including members of the japanese encephalitis virus serogroup: The present invention provides rapid and accurate methods, primers, probes and kits for identifying the presence of a certain flaviviruses in a sample. Flaviviruses that can be detected include members of the Japanese encephalitis virus serogroup, Dengue virus, St. Louis encephalitis virus, Montana myotis leukoencephalitis virus, Modoc virus, and Yellow... Agent:

20140363807 - Genetic marker for detection of human papillomavirus: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV... Agent: Trovagene, Inc.

20140363810 - Method of measuring human cyp3a inducibility: e

20140363811 - Compositions for detecting alicyclobacillus microorganisms: The invention provides nucleic acids, collections of nucleic acids, supports, assay kits, and methods for the sensitive and specific detection of microorganisms in a foodstuff. The nucleic acid comprises a nucleotide sequence selected from the group consisting of SEQ ID NOs: 1-15 and having a length of no more than... Agent:

20140363818 - Egfr and par2 regulation of intestinal permeability: The present invention provides methods for diagnosing an immune-mediated disease, e.g., an autoimmune disease, an allergy or an inflammatory disease. Diagnosis is made by detecting a heterozygous or homozygous genotype of haptoglobin 2 or by detecting and quantifying pre-haptoglobin 2 mRNA or protein. After diagnosis, the disease may be treated... Agent: University Of Maryland, Baltimore

20140363812 - Method for detecting nucleosomes containing nucleotides: The invention relates to a method for detecting and measuring the presence of mono-nucleosomes and oligo-nucleosomes and nucleosomes that contain particular nucleotides and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome associated nucleotide biomarkers for the... Agent: Singapore Volition Pte Limited

20140363817 - Method for specifically labeling living bacteria: The present invention concerns a method for labeling specifically living bacteria of a given category in a sample, the method including: a) incubating said bacteria of said sample with at least one analog of a monosaccharide compound, and b) contacting the bacteria with a labeling molecule having a second reactive... Agent:

20140363815 - Methods and kits for detection of methylation status: The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosine (5hmC) and/or 5-methylcytosine (5meC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC and/or 5meC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of... Agent:

20140363816 - Methods for prediction of clinical response to radiation therapy in cancer patients: Disclosed are biomarkers, methods and assay systems for the identification of cancer patients who are predicted to respond, or not respond to the therapeutic administration of radiation therapy to treat cancer. Thus, the invention provides a diagnostic paradigm to select cancer patients who will benefit from radiation therapy. In particular,... Agent:

20140363813 - Sperm-specific cation channel, catsper2, and uses therefor: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods... Agent:

20140363814 - Streptococcus pneumoniae detection in blood: The present invention provides a method and a kit for detecting a S. pneumoniae nucleic acid in a sample. The method comprises the steps of isolating said nucleic acid and detecting hybridization between the S. pneumoniae nucleic acid and a labeled probe, wherein the detection of hybridization comprises detecting a... Agent: Universit&#xc9 Libre De Bruxelles

20140363819 - Composition to overcome inhibitors in pcr and growth cultures: Provided herein are compositions and methods for improving amplification or detection of a target nucleic acid in a sample containing PCR inhibitors, such as polyphenols. One aspect provides an enhancer composition including casein or polyvinylpyrrolidone, or a modified polymer thereof. Another aspect provides a method of amplifying a target nucleic... Agent:

20140363820 - Method for detecting and examining traumatic brain injury in vitro: The present invention discloses a method for detecting and examining traumatic brain injury (TBI) in vitro. The method is according to the principle of expression of Etk/Bmx mRNA which is correspondingly increased when TBI occurs, so that the Etk/Bmx mRNA is defined as a quantification reference indicator specific for neurological... Agent: Taipei Medical University

20140363821 - Thermal control of droplets by nanoscale field effect transistors: Provided herein are methods and devices for rapidly and accurately heating fluid droplets surrounded by a gas-phase medium, such as air. Sub-nanoliter fluid droplets can be rapidly heated by nanoscale field effect transistors via microwave heating by an applied AC voltage to the FET. The heating is in a well-defined... Agent:

20140363822 - Compositions and methods for sample preparation: The invention relates generally to compositions and methods for disrupting cells (e.g., disrupting cellular and nuclear membranes). In particular, the invention provides modified solid surfaces (e.g., bead surfaces) and their use in disruption of cellular membranes (e.g., during cellular lysis procedures (e.g., for recovery of nucleic acid (e.g., DNA or... Agent:

20140363824 - Fluorescent metal ion indicators with large stokes shifts: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the... Agent:

20140363823 - Sensitive and rapid determination of antimicrobial susceptibility: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the... Agent: Accelerate Diagnostics, Inc.

20140363826 - Dll3 modulators and methods of use: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.... Agent: Stem Centrx, Inc.

20140363827 - Apparatus for identifying characteristic of liquid and the method thereof: An apparatus and a method for identifying the characteristics of a liquid sample due to capillary force are disclosed. The apparatus and the method spread the blood sample (which is obtained from the blood of a subject, or a mixture containing the blood of two different subjects) having an agglutination... Agent:

20140363828 - Method and device for assaying an antigen present on erythrocytes or an antibody binding to an antigen present on erythrocytes: An assaying kit is for pre-transfusion blood group matching between two blood samples. The kit includes at least two assemblies (101,201) corresponding to the first and the second blood sample, each assembly has at least two test units (1). Each test unit (1) includes a reagent containing an antigen present... Agent: Universite Libre De Bruxelles

20140363825 - Marker for detecting colorectal cancer or esophageal cancer and method for examining such cancer: This invention relates to a method for detecting or examining a cancer selected from colorectal cancer and esophageal cancer with high detection sensitivity and accuracy and with less invasiveness to a subject. Specifically, it relates to a method for examining a cancer comprising measuring in vitro a COTL1 protein in... Agent: Toray Industries, Inc.

20140363831 - Compounds and methods useful for detection and treatment of cancer: The present invention relates to compounds and methods useful for the detection and treatment of disorders associated with frameshift mutations in coding microsatellite regions. The compounds and methods are applicable in cancers, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors. The compounds are useful for... Agent:

20140363830 - Compounds that modulate hsp90 activity and methods for identifying same: The present invention relates to compositions and methods related to inhibitors of Hsp90, including substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such... Agent: Synta Pharmaceuticals Corp.

20140363829 - Method for increasing specificity of diagnostic tests for autoimmune diseases: Provided is a method for increasing the specificity of an antibody-based test to help in the diagnosis of autoimmune diseases by contacting a subject's sample with a blocking antigen prior interfering antibody present in the sample. More specifically, a method for increasing specificity of an antibody-based autoimmune disease assay comprising... Agent: Inova Diagnostics, Inc.

20140363832 - Molecular marker for the early detection of malignant pleural mesothelioma and the methods of its expression analysis using blood and pleural effusion samples: The present invention provides a method for testing mesothelioma comprising a step of determining a concentration of a human periostin protein in at least one type of sample of blood or pleural fluid of a subject. In the step of determining the concentration of human periostin protein, an antibody directed... Agent: Medical & Biological Laboratories Co., Ltd.

20140363833 - Affinity-based detection of ligand-encoded synthetic biomarkers: The invention relates to methods and products associated with in vivo enzyme profiling. In particular, biomarker nanoparticles capable of quantitatively detecting enzymatic activity in vivo are described. These nanoparticles can be used to detect in vivo enzyme activity. The invention also relates to products, kits, and databases for use in... Agent: Massachusetts Institute Of Technology

20140363834 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the... Agent:

20140363835 - Compatible solute ectoine as well as derivatives thereof for enzyme stabilization: Dry reagent compositions are disclosed for maintaining and preserving enzymatic activity. Also disclosed are test elements incorporating the same and methods of making and using the same for determining the presence or amount of an analyte in a body fluid sample. The dry reagent compositions can include components such as... Agent:

20140363836 - Method for determining the stability of organic methyleneamines in the presence of semicarbazide-sensitive amine oxidase: The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing an methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.... Agent:

20140363837 - Horseradish peroxidase isoenzymes: The present invention relates to recombinant heme-containing horseradish peroxidase isoenzymes with improved properties. In particular, the present invention relates to a plant enzyme kit comprising recombinant peroxidase isoenzymes, preferably horseradish peroxidase isoenzymes.... Agent: Technische Universitaet Graz (geaz University Of Technology

20140363841 - Induced pluripotent stem cell (ipsc)-derived cardiomyocyte-like cells and uses thereof: The present invention relates to a method for screening an agent as a drug candidate using induced pluripotent stem cell-derived cardiomyocyte-like cells (iPSC-CMs). The method is useful for screening cardiovascular agents and/or agents affecting cardiac function. The method is also useful for assessing the cardiotoxicity of agents. The present invention... Agent: Singapore Health Services Pte Ltd

20140363839 - Long wavelength fluorogenic intracellular ion indicators that are well retained in the cytosol: Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (Mc), a reporter molecule and two or more lipophilic groups (GL) covalently bonded through a linker to the reporter molecule, wherein the lipophilic groups, when present in a... Agent: Life Technologies Corporation

20140363840 - Method of determining the viability of at least one cell: This disclosure provides a method of determining the viability of at least one cell via quantification of nicotinamide adenine dinucleotide (phosphate) (NAD(P)H), flavin adenine dinucleotide (FAD), and/or collagen. The method includes the steps of contacting the at least one cell with light having a wavelength of from 700 to 900... Agent:

20140363838 - Microperfusion imaging platform: This disclosure describes the design and function of a microfluidic device for performing time course assays on 2D or 3D-cell culture models designed to interface with existing robotic, high-throughput instrumentation. The system, methods and devices described herein allow robotic handling of multiplex assay cards that allow continuous fluid flow past... Agent:

20140363842 - Radiation microdosimeters correlated with biological cells and cell components: One feature pertains to a radiation dosimeter comprising a microdosimeter cell array that includes a first microdosimeter cell having a first semiconductor volume configured to generate a first current in response to incident radiation. The first semiconductor volume may have at least one of a first size, a first shape,... Agent:

20140363843 - Systems and methods for acoustically processing tissue samples: Systems and methods for processing tissue samples using acoustic energy. The tissue sample may be collected and placed on a substrate (e.g., microscope slide), or other sample holder. A transfer substrate may be positioned on the other side of the sample opposite the substrate. A microscope incorporated with the acoustic... Agent:

20140363844 - Cyclic peptide production: An enzyme useful for producing cyclic peptides from linear peptide precursors and a gene encoding the enzyme are described. The enzyme is particularly useful for producing segetalins from linear presegetalin precursors. The linear presegetalin precursors may be derived from other linear presegetalin precursors farther upstream in the biosynthetic synthesis of... Agent:

20140363845 - Cholesterol-based media supplements for cell culture: The disclosure provides compositions and methods for high density cell culture and banking of cholesterol auxotrophic cells.... Agent: Biogen Idec Ma Inc.

20140363846 - Process for producing cellulase mixtures from myceliophthora and related organisms: The present invention provides a fermentation process for producing a cellulase enzyme mixture comprising the steps of (a) providing a fungal cell of the genus Myceliophthora or a taxonomically equivalent genus; (b) culturing the fungal cell in a submerged liquid batch culture in which the carbon source comprises about 0%... Agent: Iogen Energy Corporation

20140363847 - Microorganism having carbon dioxide fixation pathway introduced thereinto: An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA... Agent: Mitsui Chemicals, Inc.

20140363848 - Chimeric dna polymerases: The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA polymerases that have at least one distinct functional characteristics (e.g., elongation rate, processivity, error rate or fidelity, salt tolerance or resistance) and methods of making and using the same.... Agent: Kapa Biosystems, Inc.

20140363849 - Method for improving nucleic acid synthesis reaction: Provided are the following: a method, for improving reactivity of a nucleic acid synthesis reaction, comprising a step for adding an ω-amino acid to a reaction solution; a composition, for a nucleic acid synthesis reaction, comprising DNA polymerase, reaction buffer, at least one primer, at least one deoxyribonucleotide triphosphate, and... Agent: Takara Bio Inc.

20140363850 - Methods to mutate circular deoxyribonucleotides: The invention provides improved mutagenic plasmids and a method for making and using them. In one embodiment a cyclic mutagenic nucleic acid is replicated to form interlocking, digestibly separable duplex or simplex rings; and then one or more of the interlocked rings are cleaved selectively by means of a restriction... Agent: Kennesaw State University Research And Services Foundation

20140363853 - Nucleotide cloning methods: Methods of cloning insert sequences into cloning vectors with high efficiency and in the correct orientation are described. In one aspect, the invention features a method of producing a plasmid comprising an insert fragment and a vector fragment in a predetermined orientation. In some embodiments, the method includes cleaving a... Agent:

20140363851 - Methods and apparatus for synthesizing nucleic acids: The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.... Agent:

20140363852 - Methods and apparatus for synthesizing nucleic acids: The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using enzymes and specially designed nucleotide analogs. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.... Agent:

20140363854 - Thermostable reverse transcriptases and uses thereof: The present invention is in the fields of molecular and cellular biology. The invention is generally related to reverse transcriptase enzymes and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to reverse transcriptase enzymes which have been mutated or modified to... Agent:

20140363855 - Processes for increasing bioalcohol yield from biomass: A process for increasing alcohol yield from biomass (the form or agro- or forest residue, grains, hops, etc.), involving multiple hydrodynamic cavitation treatments of biomass filtrate—both before and after fermentation. Carbohydrates extracted from biomass are subjected to a first cavitation treatment to promote additional conversion into carbohydrates. The carbohydrates are... Agent: Cavitation Technologies, Inc.

20140363856 - An improved pre-hydrolysis step involving vacuum: An improved pre-hydrolysis step involving exposing water insoluble pre-treated ligno-cellulosic biomass to vacuum conditions, with and without enzymes is disclosed. After exposing the water insoluble pre-treated ligno-cellulosic biomass to vacuum conditions, enzymatic hydrolysis is conducted on the pre-treated material. The result is an increased yield of glucose and often xylose... Agent: Beta Renewables S.p.a.

20140363857 - Method for producing an l-amino acid: A method for producing an L-amino acid by preparing a processed product of a microalgae, which promotes production and accumulation of the L-amino acid by a bacterium having an ability to produce the L-amino acid, by culturing the microalgae in a medium, and processing the resulting culture at a midtemperature;... Agent: Ajinomoto Co., Inc.

20140363858 - Methods for hydroxylating phenylpropanoids: Provided herein are methods for producing an ortho-hydroxylated phenylpropanoid. In one embodiment the method includes culturing a microbe that includes HpaBC activity in the presence of a phenylpropanoid substrate. Also provided are genetically engineered microbes engineered to have greater levels of HpaB and/or HpaC than a control microbe.... Agent:

20140363859 - Recombinant microorganism having improved putrescine producing ability and method for producing putrescine by using same: The present invention relates to a recombinant microorganism having enhanced ability to produce putrescine at high yield, wherein the activity of NCgl0101 is weakened in a microorganism of genus Corynebacterium that has been modified to produce putrescine, and a method for producing putrescine using the same.... Agent: Cj Cheiljedang Corporation

20140363860 - Omega-3 desaturase used in the biosynthesis of polyunsaturated fatty acids: The present invention provides novel fatty acid desaturases genes used for synthesis of polyunsaturated fatty acids, especially ω3 desaturases (FADS15). The present invention also provides nucleic acid sequence coding the above-described desaturases, expression vector of the above-described desaturases and recombinant microorganism expressing above-described desaturases.... Agent: University Of Jiangnan

20140363861 - Methods for producing high levels of carboxylic acids by lignocellulosic biomass processing: The technology relates, in certain aspects, to the use of novel extreme thermophile microorganisms, which are able to convert lignocellulosic biomass to carboxylic acids, in particular to lactic acid and/or acetic acid, salts or esters thereof.... Agent:

20140363862 - Methods for succinate production: Provided herein are genetically modified yeast cells for the production of succinate, methods of making these yeast cells, and methods of using these cells to produce succinate.... Agent: Bioamber International S.&#xe0 .r.l.

20140363863 - Process for producing 3-hydroxybutyric acid or salt thereof: The invention provides a process for producing 3-hydroxybutyric acid or a salt thereof. The process includes (1) culturing one or more halophilic bacteria belonging to the genus Halomonas under aerobic conditions in a medium containing an inorganic salt and one or more organic carbon sources; (2) changing the culture conditions... Agent:

20140363864 - Microorganisms and methods for the production of 1,4-cyclohexanedimethanol: A non-naturally occurring microbial organism includes a microbial organism having a 1,4-cyclohexanedimethanol pathway that includes at least one exogenous nucleic acid encoding a 1,4-cyclohexanedimethanol pathway enzyme expressed in a sufficient amount to produce 1,4-cyclohexanedimethanol. A method for producing 1,4-cyclohexanedimethanol includes culturing a non-naturally occurring microbial organism having a 1,4-cyclohexanedimethanol pathway.... Agent: Genomatica, Inc.

20140363865 - Supplementation of fatty acids for improving alcohol productivity: Fatty acids derived from biomass at a step in a fermentation process can be added to a fermentation medium comprising a recombinant microorganism that produces a product alcohol. At least one of growth rate and fermentable carbon consumption of the microorganism is greater in the presence of the fatty acids... Agent: Butamax Advanced Biofuels LLC

20140363866 - Control of conductivity in anaerobic fermentation: Process are provided which are effective for controlling medium conductivity during fermentation of a CO-containing gaseous substrate while providing an STY of about 10 g ethanol/(L·day) or more. The process includes balancing medium conductivity, specific carbon uptake or cell density levels.... Agent: Ineos Bio Sa

20140363867 - Process for fermenting co-containing gaseous substrates in a low phosphate medium effective for reducing water usage: A process is provided for fermenting CO-containing gaseous substrates in a low phosphate medium. The process includes blending a liquid medium that includes at least one transition metal element with a liquid medium that includes at least at least one other transition metal element and one non-metal element to provide... Agent: Ineos Bio Sa

20140363868 - Transgenic plants and methods of using same: Provided herein are plants having altered expression of a coding region encoding a hydroxyproline-rich glycoprotein. In some embodiments the expression is decreased, and the resulting plant has decreased recalcitrance, increased growth, or a combination thereof. In some embodiments the expression is increased, and the resulting plant has decreased growth, biomass... Agent: University Of Georgia Research Foundation, Inc.

20140363869 - Single-step bioconversion of lignocellulosic biomass to biofuels using extreme thermophilic bacteria: The present technology pertains to improved methods for the conversion of lignocellulosic biomass material to bio-fuels using novel isolated cellulolytic extreme thermophilic bacterial cells belonging to the genus Caldicellulosiruptor, and mutants thereof.... Agent:

20140363871 - Process for obtaining copper nanoparticles from a fungus selected between hypocrea lixii and trichoderma koningiopsis and use of fungi selected between hypocrea lixii and trichoderma koningiopsis in bioremediation of wastewater and production of copper na: e

20140363870 - Process for obtaining copper nanoparticles from rhodotorula mucilaginosa and use of rhodotorula mucilaginosa in bioremediation of wastewater and production of copper nanoparticles:

20140363872 - Materials and methods for producing cell-surface directed and associated non-naturally occurring bioinorganic membrances and uses thereof: Materials and Methods are provided for producing cell-surface directed, non-naturally occurring, bioinorganic membranes for association with the cell surfaces of living cells. The methods comprise exposing a cell to an acidic biomineralization buffer environment for cell-mediated deposition of the biomineral membrane onto the surface of the cell. The methods also... Agent:

20140363873 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20140363874 - Method for producing laccase by means of liquid fermentation of lentinus edodes: A method for producing laccase by liquid fermentation of Lentinus edodes comprises the following steps of: (1) inoculating strains of Lentinus edodes into the PD liquid fermentation medium to perform activation culture and obtain a seed liquid; (2) inoculating the seed solution into a liquid fermentation medium to perform liquid... Agent: Institute Of Agricultural Resources & Environment Shandong Academy Of Agricultural Sciences

20140363876 - Kits and methods for generating 5' capped rna: The present invention relates to kits and methods for efficiently generating 5′ capped RNA having a modified cap nucleotide and for use of such modified-nucleotide-capped RNA molecules. In particular, the present invention provides kits and methods for capping RNA using a modified cap nucleotide and a capping enzyme system, such... Agent:

20140363875 - Novel dna polymerase: Provided are: a DNA polymerase comprising: an amino acid sequence modified from the amino acid sequence of SEQ ID NO: 12, which has a substitution of arginine at position 651 by an amino acid residue having a negatively charged side chain, preferably by asparatic acid or glutamic acid, more preferably... Agent: Kyushu University, National University Corporation

20140363877 - Process: In one aspect, there is provided a process for treating a plant oil, comprising a step of contacting the oil with an enzyme, wherein the enzyme is capable of hydrolysing an a′ or b′ stereoisomer of chlorophyll or a chlorophyll derivative.... Agent: Dupont Nutrition Biosciences, Aps

20140363878 - Recombinant negative strand virus rna expression systems and vaccines: The present invention relates to recombinant RNA virus templates derived from and applicable to negative strand naturally non-segmented viruses, including the families Bornaviridae, Filoviridae, and Paramyxoviridae, and methods for generating such recombinant RNA virus templates, wherein the templates are generated from two or more recombinant RNA molecules. The invention relates... Agent:

20140363879 - System and method for sulfur bioadaptation in a stable dispersion form for industrial bioreactor feeding: A system for sulfur (S) bioadaptation in a stable dispersion form for feeding industrial bioreactors, which are composed of a tank with a liquid medium made up of a supernatant dilution or part of a sulfur oxidizing bacterial culture, a recirculating pump fed from the tank, and an eductor which... Agent: Biosigma S.a.

20140363880 - Novel lactic acid bacterium having iga production promoting activity, and use thereof: Disclosed are: a lactic acid bacterium belonging to Lactobacillus kunkeei, the bacterium having a higher IgA production inducing activity than that of Lactobacillus strain GG (ATCC53103), and a lower mitogenic activity and a lower IL-2 production inducing activity than those of Listeria strain EGD; and a food composition, a pharmaceutical... Agent: Yamada Bee Company

20140363881 - Modular adjustable pulse generator: A pulse generation system for applying electric pulses across a load includes a first plurality of energy storage modules connected in series on a positive chain and configured to apply a positive potential to the load and a second plurality of energy storage modules connected in series on a negative... Agent:

20140363882 - Rapid detection of analytes in liquid samples: A device for detecting at least one analyte in a liquid sample generally comprises (i) a support having a chamber for receiving a biological fluid (e.g., milk) therein, wherein said chamber is an elongate chamber having a length axis; (ii) a (stationary or movable) carrier (in some embodiments in the... Agent:

20140363883 - Device for cell culture and direct imaging: A cell culture device for the study of barrier function and differentiation are provided by this invention.... Agent:

20140363884 - Cell culture tube and multiple roller tube cell culture apparatus including the same: Disclosed is a cell culture tube, having in opposite end walls two respective eccentric openings which communicate with each other through an inner straight passage formed in the cell culture tube, in which the inner straight passage is tilted at an angle relative to a longitudinal axis of the cell... Agent:

20140363885 - Tear-away multi well plate: The present invention relates to a method for producing a perforated breakable multi well plate comprising providing a multi well plate, and generating one or more perforated section lines along the width and/or length of the multi well plate by puncturing the multi well plate with a slotted blade for... Agent:

20140363887 - Dll3 modulators and methods of use: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.... Agent: Stem Centrx, Inc.

20140363886 - Method for preparing induced paraxial mesoderm progenitor (ipam) cells and their use: The present invention relates to an ex vivo method for preparing induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signaling pathway and an effective amount of an inhibitor... Agent: Cnrs (centre National De La Recherche Scientifique)

20140363888 - Method for inducing differentiation of human pluripotent stem cells into intermediate mesoderm cells: The present invention provides a method for inducing differentiation of a human pluripotent stem cell into an intermediate mesoderm cell without the use of a growth factor. Such method comprises performing culture in a medium containing a specific compound, so as to induce differentiation of a human pluripotent stem cell... Agent: Kyoto University

20140363889 - Method for producing multipolar cell: This invention provides a multipolar cell including three or more centrosomes dispersed therein and a multipolar spindle formed so as to extend from the three or more respective centrosomes. The multipolar cell production method provided by the present invention supplies cultured eukaryotic cells with a synthetic peptide as a multipolarity-inducing... Agent:

20140363890 - Three-dimensional structures for cell or tissue culture: Among others, the present invention provides devices for cell or tissue culture, comprising a three-dimensional structure, which further includes fibrils with beads and/or particles. The present invention also relates to novel methods for manufacturing devices for cell or tissue culture.... Agent:

20140363891 - Method and apparatus for processing adipose tissue: A portable apparatus for collection and processing of human biological material, such as containing adipose extracted during a lipoplasty procedure, is useful for multi-step processing to prepare a concentrated product (e.g., stromal vascular fraction) or a fat graft composition. The apparatus has a container with a containment volume with a... Agent: The Gid Group, Inc.

20140363892 - Regulatory elements and uses thereof: The present application provides novel regulatory elements including promoter sequences from marine microorganisms. The application further discloses DNA constructs containing these novel regulatory elements; transgenic cells, transgenic non-human organisms, and progeny containing these novel regulatory elements. Methods of modifying, producing, and using the regulatory elements are also disclosed. The regulatory... Agent: Synthetic Genomics, Inc.

12/04/2014 > 114 patent applications in 63 patent subcategories.

20140356850 - Apparatus for oxygenation and perfusion of tissue for organ preservation: Systems and methods of the invention generally relate to prolonging viability of bodily tissue in static cold storage and hypothermic machine perfusion techniques by reducing the rate of edema through the application of compressive force to the bodily tissue via a compression device. Compression devices of the invention may comprise... Agent:

20140356849 - Integrated organ-on-chip systems and applications of the same: In one aspect of the invention, an integrated bio-object microfluidics chip includes a fluidic network having a plurality of inlets for providing a plurality of fluids, a plurality of outlets, a bio-object chamber for accommodating at least one bio-object, a plurality of fluidic switches, and one or more pumps, coupled... Agent:

20140356851 - System and method for the re-anticoagulation of platelet rich plasma: A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell... Agent:

20140356853 - Automated nucleic acid analysis system: A nucleic acid analysis system comprising a seating area configured to receive a microfluidic cartridge; a pneumatic module configured to supply a pneumatic pressure or a vacuum to the cartridge when mounted on the seating area; a thermal module configured to control temperature in a predetermined portion of the cartridge... Agent: Samsung Electronics Co., Ltd.

20140356852 - System and method for micro-aeration based fermentation: A method and apparatus for micro-aeration of large scale fermentation systems is provided. The micro-aeration system includes a fermentation reactor, a sparging apparatus, and a micro-aeration gas mixture delivered to the fermentation reactor via the sparging apparatus. The micro-aeration gas mixture is a very low oxygen concentration mixture comprising: (i)... Agent:

20140356854 - Methods and compositions relating to mevalonate phosphate decarboxylase: Methods and compositions related to a novel mevalonatephosphate decarboxylase enzymes are provided. The methods and compositions provided herein are particularly useful for the synthesis of isopentyl phosphate. The compositions and methods provided herein may also be used in combination with isopentyl phosphate kinase for the synthesis of isopentyl diphosphate.... Agent:

20140356855 - Methods of diagnosing a disease and methods of monitoring treatment of a disease by quantifying a non-reducing end glycan residual compound and comparing to a second biomarker: Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.... Agent:

20140356864 - Analysis of colorimetric or fluorometric test assays: The present invention provides for the analysis of colorimetric or fluorometric assays by way of capturing an image of the assay on the camera (32) built into the mobile phone (30). A disposable tool (20) is provided to enable the assay to be positioned an appropriate distance from the phone... Agent:

20140356858 - Biological tag tracking of agricultural products, foods, and other items: The disclosure relates to compositions and methods for applying a biological tag to a product and detection of the biological tag on the product by another. The compositions and methods are useful for tracing the provenance of a product, such as a food product or an agricultural product.... Agent: Advanced Biological Marketing, Inc.

20140356859 - Detection of nucleic acids using unmodified gold nanoparticles: A gold nanoparticle-based colorimetric assay kit for nucleic acids from viral, bacterial and other microorganisms that detects unamplified or amplified polynucleotides in clinical specimens using unmodified AuNPs and oligotargeter polynucleotides that bind to a pathogen's nucleic acids. A method for detecting a pathogen comprising contacting a sample suspected of containing... Agent: American University Of Cairo (auc)

20140356857 - Interparticle spacing material including nucleic acid structures and use thereof: Provided is an interparticle spacing material comprising a nucleic acid structure which comprises at least one nucleic acid lattice comprising a double helix domain; and at least one metal particle which is in contact with a plane of the nucleic acid lattice, in a direction extending obliquely or perpendicularly away... Agent: Sungkyunkwan University Foundation For Corporate Collaboration

20140356861 - Method for checking the self-healing process carried out by the immune system of a test subject infected with human papilloma virus: A method and device for checking the self-healing process carried out by the immune system of a test subject infected with human papillomavirus (HPV) using one or more cell-containing samples taken from the test subject, to prevent the formation of an HPV-induced carcinoma. The method involves: (1) determining whether HPV... Agent:

20140356860 - Method for isolating nucleic acids from a veterinary whole blood sample: The present invention provides a method for isolating nucleic acids from a veterinary whole blood sample, said method comprising at least the following steps a) preparing a binding mixture comprising—the lysed sample—at least one chaotropic agent—at least one alcohol—at least one polyoxyethylene fatty alcohol ether; b) passing the binding mixture... Agent: Qiagen Gmbh

20140356856 - Method for manufacturing and using a test paper and chemical composition thereof: A method for manufacturing a test paper is disclosed in the present invention, and at least comprises the following steps. First, a chemical precursor comprising at least a reducing agent is coated onto a substrate. The substrate is then dipped into a metal salt solution comprising a plurality of metal... Agent:

20140356863 - Methods for determining the susceptibility of a virus to an attachment inhibitor: The present invention provides novel compositions and methods that can be used for determining the susceptibility of virus to an attachment inhibitor. The present invention also provides methods for predicting whether an infected individual will respond to treatment with an attachment inhibitor, thereby allowing an effective treatment regimen to be... Agent:

20140356862 - System for on-line monitoring and controlling of chemical reactions in reactors: The application describes an MRD-based reactor. The reactor is characterized by a continuous wall portion, and is in connection with a MRD, adapted for performing localized NMR spectroscopy of the medium inside the reactor. MRD-based reactors, in which the MRD is at least partially inside the reactor or reaction media,... Agent:

20140356865 - Methods and compositions for efficient base calling in sequencing reactions: The present invention is directed to methods and compositions for acquiring nucleotide sequence information of target sequences. In particular, the present invention provides methods and compositions for improving the efficiency of sequencing reactions by using fewer labels to distinguish between nucleotides and by detecting nucleotides at multiple detection positions in... Agent: Complete Genomics, Inc.

20140356866 - Computer readable medium for enabling a computer to carry out provision of information on colon cancer and marker and kit for obtaining information on colon cancer: The above object is achieved by obtaining the analysis result on methylation status of a CpG site located in a promoter region of at least one gene selected from LONRF2 and CUX2 in a DNA sample derived from the subject and providing information on colon cancer in the subject based... Agent: Sysmex Corporation

20140356873 - Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes.... Agent:

20140356871 - Diagnostic tests for the detection of inherited peripheral neuropathies: The disclosure relates to the field of human genetics, particularly the field of peripheral neuropathy, particularly inherited peripheral neuropathy. Specifically, the disclosure relates to methods and materials to detect hereditary peripheral neuropathy, more particularly autosomal recessive Charcot-Marie-Tooth disease.... Agent: Vib Vzw

20140356872 - Homologous pairing capture assay and related methods and applications: A Homologous Pairing Capture Assay is described which enables detection of coalignment between homologous DNA sequences. The assay involves ligating closely positioned homologous sequences to each other thereby generating head-to-head ligation products or inverted repeats. DNA fragments containing an inverted repeat are then converted into hairpin DNA molecules. The hairpin... Agent:

20140356868 - Macc1 as a prognostic biomarker for hepatobiliary tumors: The present invention is directed to a method of diagnosis and prognostication of a hepatobiliary tumor, the method comprising the step of determining expression of MACC1 polypeptide or of a nucleic acid encoding said MACC1 polypeptide in a biological sample.... Agent:

20140356870 - Method for transcriptional amplification of nucleic acids combining steps of different temperatures: A method of transcriptional amplification includes: (a) obtaining a mixture by combining (i) a biological sample comprising nucleic acids, (ii) amplification primers, (iii) amplification reagents including enzymes required for amplification, and (iv) at least one polyol capable of stabilizing the enzymes required for amplification; (b) denaturing the nucleic acids by... Agent:

20140356867 - Nucleic acid enrichment using cas9: A method of enriching for a fragment of a genome, as well as corresponding compositions and kits, are provided. In certain embodiments, the method comprises: (a) contacting a sample comprising fragmented DNA with a Cas9-gRNA complex comprising mutant Cas9 protein that has inactivated nuclease activity and a Cas9-associated guide RNA... Agent: Agilent Technologies, Inc.

20140356869 - Single nucleotide polymorphisms associated with dietary weight loss: The present invention relates to genetic polymorphisms associated with obesity and obesity-related phenotypes and their use in predicting if an individual looses weight during a dietary weight loss intervention program.... Agent:

20140356875 - Evaluation of the potential risk of drug induced mood disturbance and suicide: use of a dedicated platform: The present invention relates to in vitro methods for the determination of the potential toxicity of test compounds. The invention also comprises in vitro methods for the selection of therapeutical compounds useful for the treatment of pathology related to an alteration of the mechanism of the mRNA editing of ADAR... Agent:

20140356874 - Methods and apparatus for point-of-care nucleic acid amplification and detection: Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for... Agent:

20140356877 - Nucleic acid sample preparation: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids... Agent:

20140356878 - Primers and methods for determining rhd zygosity: Provided herein are primers comprising a nucleotide sequence complementary to a portion of a RhD gene. Also provided herein are methods of determining a RhD zygosity in a subject. Also provided are methods of detecting a weak D allele in a subject. Further provided are kits for determining an RhD... Agent:

20140356876 - Systems and methods for imaging and processing tissue: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest... Agent:

20140356879 - Genes conferring tolerance to ethanol and high temperature for yeasts: Methods of identifying genes conferring ethanol tolerance in yeasts, genes that confer ethanol tolerance, and mutant strains used to identify such genes are described. A gene herein designated HpETT1 was isolated from the yeast Hansenula polymorpha. Expression of HpETT1 in an ethanol sensitive mutant H. polymorpha strain designated 7E complimented... Agent:

20140356880 - Apparatus for automated determining of at least two different process parameters: An apparatus for automated determining of at least two different process parameters of a process liquid of a process, especially a bioprocess, comprising: a first measuring cell, which is embodied to provide a first measurement signal dependent on a first process parameter of a first sample of the process liquid;... Agent: Endress + Hauser Conducta Gesellschaft F&#xfc R Mess- Und Regeltechnik Mbh + Co. Kg

20140356881 - Inspection instrument, inspection system, and inspection method: With an inspection instrument in which an optical window is disposed so as to enable optical detection in a sample holder, an analysis involving use of a three-order nonlinear Raman scattering microscope, a treatment with an agent, such as staining, and an analysis involving use of a normal optical microscope... Agent: Canon Kabushiki Kaisha

20140356884 - Boundary layer suction for cell capture: Capturing particles includes introducing a fluid sample, which includes particles of a first type, into a first channel of a microfluidic device and flowing the fluid sample past a porous or partially porous membrane. The pores fluidly connect the first channel to a second channel, and the device further includes... Agent:

20140356883 - Method for evaluating the sensitivity and specificity of fast malaria- diagnosis test kits: The invention relates to a method for evaluating kits for rapid diagnosis of malaria, in order to determine or to test the sensitivity and specificity thereof. To that end, the reactive strips of the diagnostic kits are exposed to different concentrations of the malaria parasite in a method that allows... Agent: Instituto Nacional De Salud

20140356882 - Non-invasive enzyme screen for tissue remodelling-associated conditions: Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of metastatic cancer by the identification of high molecular... Agent: Children's Medical Center Corporation

20140356885 - Reducing non-specifically bound molecules on supports: Methods and reagents are disclosed for preparing a support for reaction of the support with an assay molecule. In the method the support is treated with a detergent at a concentration of about 0.01% to about 5% (by weight) at a temperature of about 4° C. to about 50° C.... Agent: Siemens Healthcare Diagnostics Inc.

20140356886 - Method for measuring beta-glucan, and beta-glucan-binding protein for use in the method: Disclosed are a method for measuring βG comprising the steps of bringing a sample into contact with a βG-binding protein 1 and a βG-binding protein 2, each comprising an amino acid sequence which is identical or substantially identical to an amino acid sequence shown in any one of SEQ ID... Agent:

20140356887 - Glucose dehydrogenase: Amino acid mutation(s) can be introduced to Sclerotinia sclerotiorum- or Aspergillus niger-derived glucose dehydrogenase to obtain a glucose dehydrogenase variant with significantly enhanced productivity in E. coli. The glucose dehydrogenase of the present invention is low reactive with xylose.... Agent: Ultizyme International Ltd.

20140356888 - Method of detecting a salmonella microorganism: A method of detecting a Salmonella microorganism is provided. The method includes the use of a selective growth medium, a first indicator system that is converted to a first detectable product by a Salmonella microorganism, and a second indicator system that is converted to a second detectable product by β-galactosidase... Agent:

20140356889 - Composition from lobster hemocyte extracts for detection of lipopolysaccharides, peptidoglycans and 1,3-beta-d-glucans: The present invention relates to the pharmaceutics, biotechnological and chemical, and particularly to a process for preparing a composition for detecting and measuring the concentration of endotoxins or lipopolysaccharides, peptidoglycans and (1,3)-β-D-glucans, using an extract from the hemocytes of the lobster as a starting material, the changes to the composition... Agent:

20140356895 - Bacteria analyzing method and specimen analyzer: Disclosed is a bacteria analyzing method comprising: irradiating with light a measurement sample prepared by mixing a specimen and a reagent; obtaining two types of optical information from each of at least some particles contained in the measurement sample; and generating a measurement result of the specimen with a flag... Agent: Sysmex Corporation

20140356893 - Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation: Methods are described for using compositions containing platelet-rich plasma for the treatment of a variety of tissue lesions, and the use of compositions containing platelet-rich plasma to accelerate or complete the differentiation of a cell line. Particularly, use of platelet-rich plasma in conjunction with cell differentiation.... Agent:

20140356891 - Determining the dynamic state of analytes by magnetic flow measurement: Devices and methods for magnetic flow measurement are provided. Individual analytes are detected in the through-flow, and a dynamic detection of a changing analyte state is carried out, for example with respect to the analyte size or morphology. For this purpose, the analytes to be detected, such as cells for... Agent:

20140356897 - In vivo label-free histology by photoacoustic microscopy of cell nuclei: The present disclosure is directed to methods of non-invasively imaging cell nuclei. More particularly, the present disclosure is directed to methods of imaging cell nuclei in vivo using ultraviolet photoacoustic microscopy (UV-PAM), in which ultraviolet light is used to excite unlabeled DNA and RNA in cell nuclei to produce photoacoustic... Agent:

20140356890 - Method of re-collecting target material: A method of re-collecting a target material using a filter is provided. The method includes reversely flowing a first fluid from a first flow channel towards a second flow channel through a filter unit so that the target material is included in the first fluid that flows through the second... Agent: Samsung Electronics Co., Ltd.

20140356892 - Optical stimulation device: In an aspect of the disclosure, a stimulation device includes a probe attached to a first support. The probe includes at least one grating coupler for coupling light into the probe. The device further includes at least one optical source for providing an optical stimulation signal mounted on a second... Agent: Katholieke Universiteit Leuven, Ku Leuven R&d

20140356894 - Site-specific orthogonal labeling of the carboxy terminus of alpha-tubulin in live cells: A technique is provided to visualize microtubules in live cells that does not require genetic manipulation or microinjection. Moreover, this method also avoids perturbation of the endogenous microtubule network that occurs with taxol treatment. This technique exploits tyrosination and detyrosination of tubulin, a posttranslational modification cycle specific to the C-terminus... Agent: The Research Foundation For The State University Of New York

20140356896 - Transmembrane protein as biosensors: The disclosure relates to engineered transport proteins comprising at last one fluorescent reporter covalently bound to the transporter protein, wherein the transporter proteins comprise a structural inverted repeat motif, with the motif comprising a first and second subunit that are structural inverted repeats of one another and that are joined... Agent:

20140356898 - Devices and methods for overlaying blood or cellular suspensions: A device is described that overlays a first fluid, such as blood or a cellular suspension onto a base material, such as a density gradient. In some embodiments, the fluid layering device includes a cylindrical reservoir, a fluid barrier, a coupling extension, a plunger, and an exhaust vent. The fluid... Agent:

20140356899 - Biological contamination modeling of surfaces in hot humid air: d

20140356900 - Detection of luminal urinary catheter colonization: Technologies are generally described for indwelling medical devices for detection of luminal catheter colonization. A substrate for use as an indwelling medical device includes an elevated biofilm releasing medium including a dye for release into urine on the occurrence of an elevated biofilm build-up on the substrate in the urine;... Agent: Empire Technology Development LLC

20140356901 - Method and device for detecting device colonization: Technologies are generally described for a method and a device for detecting device colonization. Disclosed herein is an indwelling medical device configured to detect a biofilm. The device comprises a substrate configured to contact blood and a detecting material, disposed with the substrate, configured to detect the presence of a... Agent: Empire Technology Development LLC

20140356902 - Method for discovering algal strains with reduced pigment to attain higher photosynthetic efficiency: A method for determining and/or engineering photosynthetic mutant algal strains comprising: (A) pre-screening wild-type or parent strains to select for photosynthetic efficiency; (B) cause genetic mutations in the group of wild-type and/or parent strains from pre-screening (A) to form genetic mutant strains; (C) screening the genetic mutant strains for photosynthetic... Agent: Exxonmobil Research And Engineering Company

20140356903 - Hematological analyzer, method for analyzing body fluid and computer program product: A hematological analyzer for measuring blood, sets a body fluid measurement mode; receives a measurement start instruction; irradiates a measurement sample with light and obtains optical information from cells contained in the measurement sample; and classifies at least white blood cells and nucleated cells other than white blood cells contained... Agent: Sysmex Corporation

20140356904 - Baculovirus expression systems: The present invention relates to an optimized baculovirus construct useful for the production of virus (-like) particles or viral vectors, in particular viral vectors for gene therapy.... Agent: Genethon

20140356905 - Mammalian cell culture system for large-scale expression of recombinant proteins: Compositions and methods for large-scale recombinant protein expression are disclosed.... Agent: Rutgers, The State University Of New Jersey

20140356906 - Methods and products for transfecting cells: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods,... Agent: Factor Bioscience Inc.

20140356907 - Antibody production: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.... Agent: Erasmus University Medical Center

20140356908 - Binding molecules: A transgenic non-human mammal containing a heterologous heavy chain gene locus that is capable of producing soluble heavy chain only antibodies and antigen-binding fragments thereof following immunization.... Agent: Erasmus University Medical Center

20140356909 - Il-17 binding proteins: Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.... Agent: Abbvie Inc.

20140356911 - Method for producing protein: The present invention relates to a recombinant host cell, wherein the cell is modified to increase the expression levels of Ero1 and XBP1 relative to the expression levels of Ero1 and XBP1 in an unmodified cell. The present invention also relates to a method of producing a recombinant protein of... Agent: Ucb Pharma S.a.

20140356910 - Methods for increasing mannose content of recombinant proteins: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.... Agent: Amgen Inc.

20140356912 - Cell-based production of nonulosonates: The present invention relates to the the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-□-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-□-D-glucopyranose. Methods for producing the sugars are also provided.... Agent:

20140356914 - Endoglucanase 1b: The present invention provides endoglucanase 1b (EG1b) suitable for use in saccharification reactions.... Agent: Codexis, Inc.

20140356913 - Enzymes manufactured in transgenic soybean for plant biomass engineering and organopollutant bioremediation: A strategy for eliminating or greatly reducing the need for physical/chemical treatments or the use of whole microbes for lignocellulosic biomass and organopollutant degradation is disclosed. The soybean is a practical, cost-efficient and sustainable bioreactor for the production of lignin-degrading and cellulose-degrading enzymes. The use of soybean as a transgenic... Agent:

20140356915 - Integrated biorefineries for production of sugars, fermentation products, and coproducts: Processes are described for fractionating lignocellulosic biomass into cellulose, hemicellulose, and lignin, comprising fractionating lignocellulosic biomass in the presence of a solvent for lignin (such as ethanol), a hydrolysis catalyst (such as sulfur dioxide), and water, to produce a liquor containing hemicellulose, cellulose-rich solids, and lignin; hydrolyzing the hemicellulose to... Agent: Api Intellectual Property Holdings, LLC

20140356916 - Processes and recombinant microorganisms for the production of fine chemicals: Recombinant microorganisms with deregulated succinyl-CoA synthetase activity, as well as the uses for producing lysine, β-lysine, cadaverine or N-acetylcadaverine thereby are provided. Recombinant polypeptides comprising an amino acid sequence being at least 80% identical to SEQ ID NO: 51 or 53 are also provided. The method of producing fine chemicals... Agent: Basf Se

20140356917 - Process for producing lipids suitable for biofuels: The present invention provides a cost effective biotechnological process for production of bio-fuels from isolated and characterized microalgae. The algal strains used in the present invention having higher biomass, higher lipid productivity, higher pH and temperature tolerance are selected from the group consisting of Chlorella vulgaris iOC-1, Chlorella vulgaris iOC-2,... Agent: Indian Oil Corporation Ltd.

20140356918 - Process for synthesizing bifunctional hydrocarbon-based compounds from biomass: The subject of the present invention is a process for synthesizing bifunctional hydrocarbon-based compounds from biomass, comprising a step of fermentation of the biomass and a step of oxidation of the intermediate compounds resulting from the fermentation step.... Agent: Arkema France

20140356919 - Organisms for the production of cyclohexanone: A non-naturally occurring microbial organism has cyclohexanone pathways that include at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. A pathway includes a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on C—C bond), a 2-ketocyclohexane-1-carboxylate decarboxylase and an enzyme selected from a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxyl-CoA transferase, and a... Agent:

20140356920 - Recovery of higher alcohols from dilute aqueous solutions: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allow recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation... Agent: Gevo, Inc.

20140356924 - Alpha-amylase variant with altered properties: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.... Agent:

20140356923 - Bacteria with reconstructed transcriptional units and the uses thereof: The present invention relates to recombinant bacteria and the uses thereof, particularly for the production of ethanol. The invention also relates to methods for the production of such bacteria, as well as to nucleic acid constructs suitable for such production. The invention specifically relates to bacteria having a reconstructed biomass... Agent:

20140356921 - Engineering microorganisms to increase ethanol production by metabolic redirection: The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting organisms that have been genetically modified to allow the production of ethanol at a high yield by redirecting carbon flux at key steps... Agent: Mascoma Corporation

20140356922 - Polypeptides having glucoamylase activity and method of producing the same: The present invention relates to polypeptides having glucoamylase activity with improved properties and to compositions comprising these polypeptides suitable for use in the production of a food, beverage (e.g. beer), feed, or biofuel. Also described is an improved and cost-effective process for isolating glucoamylases suitable for large scale protein purification... Agent:

20140356925 - Polypeptide capable of enhancing cellulosic biomass degradation: The saccharification efficiency of cellulase is enhanced within reaction temperature regions of general fermenting microorganisms other than heat-resistant yeast. Cellulosic biomass is saccharified with cellulase in the presence of a polypeptide comprising the amino acid sequence shown in SEQ ID NO: 2 or 4 and having a function of enhancing... Agent: Toyota Jidosha Kabushiki Kaisha

20140356926 - Novel sesquiterpene synthase gene and protein: The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene synthase (CVS) which codes for at least one CVS. The invention further provides nucleic acids comprising the nucleotide sequence coding for amino acid residues... Agent:

20140356927 - Anaerobic process: The invention relates to processes and equipment for treatment of a feedstock by anaerobic organisms to produce a methane containing biogas that can be used as a source of energy. The invention is particularly concerned with producing methane from a waste plant material such as produced by fermentation processes used... Agent: Blaygow Limited

20140356928 - Amadoriase with improved thermostability, gene and recombinant dna for the amadoriase, and method for production of amadoriase with improved thermostability: An amadoriase having a substitution or a deletion of one or more amino acid residues at positions corresponding to amino acids selected from the group consisting of three amino acid residues from the carboxyl terminal and amino acids at positions 151, 43, 53, 267, 350, 185, 196, 299 and 323... Agent:

20140356929 - Expression vector for an improved protein secretion: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes... Agent: Basf Se

20140356930 - Immune system enhancing immunotherapy for the treatment of cancer: This application discloses immunoconjugates comprising antibodies against a particular target (such as cancer associated antigen or cancer specific antigen) that are conjugated with an immune enhancer, recruiter or solicitor. Also discloses are compositions and methods of using the inventive immunoconjugates to treat cancer.... Agent:

20140356931 - Method and system for the culture of microalgae: Described is a method for the culture of microalgae, comprising: providing a consortium of at least two living species of microalgae; culturing under illumination the consortium in a controllable bioreactor and under non-sterile aqueous culture conditions; and controlling the culture conditions for affecting at least one of the following output:... Agent: Institut National D'optique

20140356932 - Waste disposal apparatus: A waste disposal apparatus, for disposing of waste materials using aerobic decomposition, includes a decomposition chamber (14) including a waste inlet (34) for receiving waste materials, a waste outlet (70) for discharging waste materials from the chamber after aerobic decomposition thereof, and a sieve element (16) located within the decomposition... Agent:

20140356933 - Apparatus for oxygenation and perfusion of tissue for organ preservation: An apparatus according to an embodiment is configured to oxygenate and perfuse a bodily tissue for extracorporeal preservation of the bodily tissue. The apparatus includes a pneumatic system, a pumping chamber, and an organ chamber. The pneumatic system is configured for the controlled delivery of fluid to and from the... Agent:

20140356934 - Incubation chamber: An incubation chamber (10) having a water reservoir (12) has a climate controlling device, which makes it possible to set a desired temperature, as well as an object holder (18) for biological or chemical specimens. To make defined and replicable conditions possible, for instance for digestion processes of proteins, it... Agent: Sunchrom Gmbh

20140356935 - Information notification sample processing system and methods of biological slide processing: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential... Agent:

20140356936 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent:

20140356938 - Method for performing a blood count and determining the morphology of a blood smear: m

20140356937 - Patterned capillary device and process for fabricating thereof: A patterned capillary device comprising a pattern on an inner surface is described herein. More specifically, the patterned capillary device comprises a wall having an outer surface and an inner surface, the wall defining a fluidic channel. A substantially opaque film covers the inner surface of the wall, the opaque... Agent:

20140356939 - Cell separation container: A cell separation container includes a collection chamber and a tissue holding chamber which are partitioned by a filter. The cell separation container includes a first air pressure adjuster configured to adjust the inflow and outflow of gas in the collection chamber and a second air pressure adjuster configured to... Agent: Japan Tissue Engineering Co., Ltd

20140356940 - Waste biofermenter, based on temperature control by means of heating and cooling an added liquid or gaseous solution for energy-use optimization: The present invention comprises a waste-bio-fermenter device based on temperature control by means of heating and cooling an added liquid or gaseous solution, for energy-use optimization. The device makes it possible to utilize, for energy purposes, biomass and gases that result from anaerobic biodigestion in the thermophilic phase, said device... Agent: Soli&mi&#xc9 Res Energia Sustentabilidade E Gerenciamente Ambiental Ltda

20140356941 - Cartridge for preparing a sample fluid containing cells for analysis: A cartridge configured for use in a blood analyzer is provided. The cartridge may include a substantially rigid frame, a flow path within the rigid frame, at least one opening in the substantially rigid frame configured to align and stabilize a capillary tube, and a seal within the flow path.... Agent:

20140356942 - Isolator: An isolator includes: a chamber including a working chamber in which a work is performed by a worker, and a storage chamber provided under the working chamber in communication with an opening formed in a bottom plate of the working chamber, the chamber being configured to isolate the working chamber... Agent:

20140356943 - Reprogrammation of eukaryotic cells with engineered microvesicles: The present invention relates to a non-genetic, detergent-free, bacteria-free method for reprogramming a eukaryotic cell, in particular for obtaining induced pluripotent stem cells (iPS), by using engineered microvesicles carrying at least one reprogramming transcription factor, wherein said engineered microvesicles are virus-free.... Agent: Inserm (institut National De La Sante Et De La Recherche Medicale)

20140356944 - Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3′-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and... Agent:

20140356945 - Potential regenerative cell and its culturing method: The present invention relates to a type of cell—potential regenerative cell (PRC) capable of continuous proliferation, and generated mammal (including human) cells, tissues and tissue-organs by in vitro culture and replication of PRCs. The present invention also relates to the methods and cell growth regulators for culturing mammal (including human)... Agent:

20140356949 - Cell carrier, associated methods for making cell carrier and culturing cells using the same: A carrier for expansion of induced pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces.... Agent:

20140356946 - Lentiviral vectors containing an mhc class i, mhc class ii, or b2 microglobulin upstream promoter sequence: The present invention relates to the insertion of an MHC class I, MHC Class II, or β2 microglobulin upstream promoter sequence into a lentiviral vector to increase viral titers. The invention encompasses these vectors, methods of making the vectors, and methods of using them, including medicinal uses.... Agent: Theravectys

20140356948 - Method for stably preserving useful substances of cells at room temperature: There is provided a method for stably preserving cells and valuable materials included in the cells at room temperature by lyophilizing the cells. When the cells are lyophilized using a lyoprotectant, damage to the structure of the cells which may otherwise occur during a freezing process can be prevented, the... Agent: Tego Science Inc.

20140356947 - Methods and compositions for somatic cell proliferation and viability: Methods and compositions for somatic cell proliferation as well as increasing viability of somatic cells are provided. The compositions include heparin binding protein isolated from a medium conditioned by growth of pluripotent stem cells, such as, human embryonic stem cells, human embryonic carcinoma cells. The methods include contacting a somatic... Agent:

20140356950 - Methods of deriving mammalian pluripotent stem cell lines: A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.... Agent:

20140356951 - Differentiating induced pluripotent stem cells into glucose-responsive, insulin-secreting progeny: This document provides methods and materials related to differentiating iPS cells into glucose-responsive, insulin-secreting progeny. For example, methods and material for using indolactam V (ILV) and glucagon like peptide-1 (GLP-1) to produce glucose-responsive, insulin-secreting progeny from iPS cells are provided.... Agent:

20140356952 - Derivation of embryonic stem cells and embryo-derived cells: This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to... Agent: Advanced Cell Technology, Inc.

20140356953 - Dispensing unit for dispensing preservation fluid into a tissue sample container: The invention relates to a dispensing unit for dispensing fluid into an external container. The dispensing unit comprises: a connector, a reagent cylinder for storing the fluid, and a locking ring. The connector comprises an upper fastener, and a bottom wall with at least one passage therethrough. The reagent cylinder... Agent:

20140356954 - Method for producing different populations of molecules or fine particles with arbitrary distribution forms and distribution densities simultaneously and in quantity, and masking member therefor: A masking member contains parallel through-holes, each of the through-holes contains a tilted wall structure; an upper end of the tilted wall structure of one of the through-holes abuts on an upper end of the tilted wall structure of an adjacent one of the through-holes thereby forming a knife-edge ridge... Agent:

20140356955 - Ferromagnetic cell and tissue culture microcarriers: A porous, collagen coated, ferromagnetic cell culture microcarrier, which is suitable for in vitro cell and tissue culture and which facilitates 3D multicellular construct generation. Also provided is a method for creating batches of microcarriers which have inserted within them magnetite (Fe3O4) in the presence of collagen, thus creating a... Agent: University Of South Florida

20140356956 - Rna-guided transcriptional regulation: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding... Agent:

20140356957 - Biological pacemaker: Disclosed are methods and systems for modulating electrical behavior of cardiac cells. Preferred methods include administering a polynucleotide or cell-based composition that can modulate cardiac contraction to desired levels, i.e., the administered composition functions as a biological pacemaker.... Agent: The Johns Hopkins University

20140356958 - Rna-guided human genome engineering: A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in... Agent:

20140356959 - Rna-guided transcriptional regulation: Methods of modulating expression of a target nucleic acid in a cell are provided including introducing into the cell a first foreign nucleic acid encoding one or more RNAs complementary to DNA, wherein the DNA includes the target nucleic acid, introducing into the cell a second foreign nucleic acid encoding... Agent:

20140356960 - Nucleic acids for cloning and expressing multiprotein complexes: The present invention relates to a nucleic acid containing at least one homing endonuclease site (HE) and at least one restriction enzyme site (X) wherein the HE and X sites are selected such that HE and X result in compatible cohesive ends when cut by the homing endonuclease and restriction... Agent:

20140356961 - Use of phased small rnas for suppression of plant defense and other plant genes: A method for generating a phased siRNA (phasiRNA) in a plant cell comprises introducing into the plant cell an effective amount of a microRNA (miRNA). A transcript of a NB-LRR encoding gene may be cleaved in the plant cell. Resistance of the plant to a microbe may be reduced. The... Agent: University Of Delaware Technology Park

20140356962 - Novel attenuated poliovirus: pv-1 mono-cre-x: A novel and stable attenuated poliovirus is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region (with inactivation of the native ere element located in the coding region of 2C (mono-crePV), and replacing the nucleic acid sequence of all or part of the capsid coding... Agent:

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