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Chemistry: molecular biology and microbiology

20130115588 - Integrated bioreactor and separation system and methods of use therof: The present invention relates to methods and systems for culturing and purifying target substance(s), such as selected proteins, viruses, pathogenic bacteria, antibodies, antigens, clotting factors, glycoproteins, and hormones, from source liquids wherein the culturing and purification is effected in an integrated system including a bioreactor and at least one separation... Agent: Smartflow Technologies, Inc.

20130115590 - Materials and method for immobilizing, isolating, and concentrating cells using carboxylated surfaces: The present disclosure relates to immobilization of a cell using a carboxylated surface by contacting the carboxylated surface with a sample comprising the cell for a sufficient time to permit the cell to bind to the carboxylated surface. The immobilized cell may then be separated from the remainder of the... Agent: Qiagen Gaithersburg, Inc.

20130115592 - Modified human hepatitis c virus genomic rna that can be autonomously replicated: The present invention provides modified hepatitis C virus genomic RNA, comprising nucleotide sequences of genomic RNA portions of two or more types of hepatitis C viruses, which comprises a 5′ untranslated region, a core protein coding sequence, an E1 protein coding sequence, a p7 protein coding sequence, an E2 protein... Agent: Tokyo Metropolitan Institute Of Medical Science

20130115591 - Molecular method for universal detection of citrus viroids: The present invention provides methods for universally detecting citrus viroids in plant material such as germplasm. In particular embodiments, the invention enables the determination of citrus viroid infection and plant resistance. Accordingly, the present method provides methods for improved universal detection of any citrus viroid.... Agent: Regents Of The University Of California

20130115589 - Pharmaceutical composition for treatment and prevention of herpes virus infections: e

20130115593 - Substrates for chromogenic detection and methods of use in detection assays and kits: Embodiments of substrates and processes for chromogenic detection, and in particular pyrazolyl dihydrogen phosphate compounds, are disclosed.... Agent: Ventana Medical Systems, Inc.

20130115596 - Dna polymorphisms as molecular markers in cattle: A method of predicting the phenotype of cattle through the analysis of one or more single nucleotide polymorphisms (SNPs) is described. More particularly, a method for predicting cattle temperament and behavior through the analysis of one or more single nucleotide polymorphisms (SNPs) mapped at specific regions of the bovine genome... Agent: The Governors Of The University Of Alberta

20130115602 - Endogenetic retroviral sequences, associated with autoimmune diseases or with pregnancy disorders: A genomic retroviral nucleic material, in an isolated or purified state, at least partially functional or non-functional, wherein the genome comprises a reference nucleotide sequence selected from the group including sequences of SEQ ID NOs: 1-15, their complementary sequences, and their equivalent sequences, in particular, nucleotide sequences having, for every... Agent: Biomerieux

20130115594 - High specificity and high sensitivity detection based on steric hindrance & enzyme-related signal amplification: The present invention relates to a molecular probe capable of high sensitivity and high specificity detection of a target nucleic acid in a sample. Also disclosed is a detection method using this probe.... Agent: The Regents Of The University Of California

20130115599 - Increased cip2a expression and bladder cancer in humans: The present invention provides a method of detecting CIP2A protein in a bladder tissue. Methods and compositions are provided herein for detecting and diagnosing bladder cancer by obtaining a bladder tissue from a human subject suspected of bladder cancer, followed by detecting CIP2A protein or mRNA levels in the bladder... Agent: Medical Diagnostic Laboratories, LLC

20130115597 - Method for detecting specific nucleic acid sequences: The present invention relates to a method and test kit for detecting specific nucleic acid sequences, comprising the steps of: 1. matrix-dependent new synthesis of the target nucleic acid; 2. target-specific probe hybridization; and 3. detection of the hybridization event. The invention is characterized in that, in the first step,... Agent: Aj Innuscreen Gmbh

20130115595 - Method to detect repeat sequence motifs in nucleic acid: Methods for determining the presence or absence of expansion of CGG repeat sequence in the FMR1 gene presence or absence of expansion of CCG repeat sequence in the FMR2 gene are provided. The methods are useful in identifying an individual with normal/intermediate, versus premutation or full mutation allele of FMR1... Agent: Quest Diagnostics Investments Incorporated

20130115598 - Oligonucleotide probe retrieval assay for dna transactions in mammalian cells: Methods to measure a variety of DNA synthetic processes in live human cells by introducing and retrieving exogenous DNA probes are provided herein. Using fragments of bacterial plasmid or phage DNA, a wide array of DNA constructs may be assembled to mimic the intermediates of DNA transactions, including replication, translation... Agent:

20130115600 - Sequences and their use for detection of salmonella: This invention relates to a rapid method for detection of Salmonella in a sample based on the presence of nucleic acid sequences, in particular, to a PCR-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. In certain embodiments, the method is employed to detect Salmonella... Agent: E. I. Du Pont De Nemours And Company

20130115601 - Tissue typing assays and kits: The present invention relates generally to compositions of lyophilised reagents suitable for nucleic acid amplification use in in-vitro diagnostics. More particularly, the invention relates to lyophilised PCR reagent compositions and methods for genotyping including HLA and/or ABO and/or HFE typing.... Agent:

20130115616 - Detection of nucleic acids by agglutination: Embodiments of the invention relate generally to methods detecting, quantifying, or purifying nucleic acids by way of agglutination reactions. Several embodiments amplify target nucleic acids while incorporating a label such as 5-methyl-cytosine into amplified product and detecting, quantifying, or purifying the product with latex beads coupled to antibody reactive to... Agent: Hitachi Chemical Co., Ltd.

20130115612 - Method for analyzing mucin 1 having siaalpha2-8siaalpha2-3galbeta glycans: The object of the present invention is to provide a clinical marker capable of distinguishing breast cancer from interstitial pneumonia; and a clinical marker for detecting malignancy or progress level of breast cancer, and for monitoring effects of the treatment of breast cancer. The object can be solved by a... Agent: Tokyo Institute Of Technology

20130115614 - Method for detecting and quantifying endogenous wheat dna sequence: A primer pair is provided capable of amplifying partial sequences of endogenous wheat DNA which are single copies and which allow wheat to be specifically detected without cross-reacting with other plants in a polymerase chain reaction. Also provided is a kit for detecting or assaying an endogenous wheat DNA sequence... Agent: Nisshin Seifun Group Inc.

20130115605 - Method for preparative production of long nucleic acids by pcr: The invention relates to a method for preparative production of long nucleic acids by PCR. The method involves the following hybridization steps: a) a nucleic acid base sequence is hybridized on the 3′ and 5′ ends with an adapter primer; b) the product from step a) is hybridized on the... Agent: Rina-netzwerk Rna-technolgien Gmbh

20130115615 - Method of classifying human subjects having adolescent idiopathic scoliosis (ais) and method for screening for a compound useful in the treatment of ais and related syndromes causing spinal deformities: A method of classifying a human subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting an impairment in melatonin-signaling pathway in the sample in the presence and in the absence of a known melatonin-signaling pathway agonist, whereby the results of the detecting step... Agent: Hopital Sainte-justine

20130115610 - Method of identifying prebiotics and compositions containing the same: A method for identifying test agents that exhibit prebiotic activity on human skin commensal microorganisms and compositions that include such agents. The method includes providing a test culture of a test agent, a human skin commensal microorganism and a minimal carbon medium. The method provides a time efficient and cost... Agent: The Procter & Gamble Company

20130115609 - Methods and kits for detecting circulating cancer stem cells: Disclosed herein is the use of LIN28B gene or a variant thereof as a cancer stem cell marker gene for the diagnosis, treatment, or prognosis of a malignant tumor such as hepatocellular carcinoma. Also included herein are methods and kits for detecting circulating cancer stem cells in a subject. According... Agent: National Cheng Kung University

20130115604 - Methods and materials for the diagnosis of prostate cancers: Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in a biological sample obtained from the subject and comparing the levels of expression with predetermined threshold levels. Levels of expression of at least two... Agent: Caldera Health Limited

20130115603 - Nucleotide repeat expansion-associated polypeptides and uses thereof: Isolated polypeptides that are endogenously expressed from nucleotide repeat expansions are disclosed. In some cases, the polypeptides include polypeptide repeats. In some cases, the polypeptide repeats include at least five contiguous repeats of a single amino acid. In other cases, the repeats include at least six contiguous amino acids of... Agent: Regents Of The University Of Minnesota

20130115607 - Sample preparation, processing and analysis systems: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic... Agent: Integenx Inc.

20130115613 - Screening assays based on mag and/or abhd6 for selecting insulin secretion promoting agent: The present application relates to a method of characterizing an agent's ability to increase insulin secretion in a subject. The method comprises determining whether the agent is able to modulate MAG level at the inner surface of the cytoplasmic membrane of a cell and/or ABHD6 activity. The agent is characterized... Agent: Val-chum, Limited Partnership

20130115608 - Screening methods for ocular irritation and toxicity: Methods of determining a level of ocular irritation and/or toxicity for a chemical compound are described. Kits for use in methods of determining a level of ocular irritation and/or toxicity for a chemical compound are also described.... Agent: Ceetox, Inc.

20130115606 - System and method for microfluidic cell culture: Microfluidic devices and methods for perfusing a cell with perfusion fluid are provided herein, wherein the gravitational forces acting on the cell to keep the cell at or near a retainer or a retaining position exceed the hydrodynamic forces acting on the cell to move it toward an outlet. Also... Agent: The University Of British Columbia

20130115611 - Systems and methods for calibration using dye signal amplification: The present teachings relate to a method of generating calibration information during a real-time polymerase chain reaction (RT-PCR) or other amplification reaction. A sample well plate or other support can contain one or more dyes or other reference materials that are subjected to the same RT-PCR thermal cycles or other... Agent: Applied Biosystems, LLC

20130115617 - Methods of cell culture for adoptive cell therapy: Production and use of novel therapeutic cells, called T-Vehicles, in the allogeneic Adoptive Cell Therapy setting allows a wide range of therapeutic benefits to accrue with minimal or no risk of GVHD. T-Vehicles are created from donor T cells that are altered to contain therapeutic attributes that do not include... Agent:

20130115620 - Novel hemopoietin receptor protein, nr10: The inventors succeeded in isolating a novel hemopoietin receptor gene (NR10) using a sequence predicted from the extracted motif conserved in the amino acid sequences of known hemopoietin receptors. It was expected that two forms of NR10 exists, a transmembrane type and soluble form. Expression of the former type was... Agent: Chugai Seiyaku Kabushiki Kaisha

20130115618 - Phospholipid profiling and cancer: In general, the present invention provides prognostic and predictive methods and kits for determining the lipogenicity of a tumor in a subject, by making use of phospholipid profiling, whereby a relative increase in mono-unsaturated phospholipid species in combination with a relative decrease in poly-unsaturated phospholipid species is indicative for a... Agent: Katholieke Universiteit Leuven

20130115619 - Ubiquitination assay: The present invention related to a method of assaying ubiquitination in a sample by combining ubiquitin and two or more of E1, E2, E3 and a substrate protein in a sample under conditions suitable for ubiquitination to take place, exposing the sample with a labelled binding partner which is specific... Agent:

20130115626 - Anti-neuropilin antibodies and methods of use: The invention provides anti-NRP1 antibodies and methods of using the same.... Agent: Genentech, Inc.

20130115627 - Methods for identifying candidate cytotoxic antibody molecules: The disclosure relates to methods for screening candidate antibody molecules which bind to podocalyxin-like protein (PODXL) and/or to undifferentiated pluripotent stem cells and particularly, although not exclusively, to methods for identifying candidate cytotoxic antibody molecules.... Agent: Agency For Science, Technology And Research

20130115624 - Methods to identify modulators: Disclosed are compounds that activate the human G-protein coupled receptor TAS2R41, and methods of using these compounds for identifying compounds that modulate the response of the TAS2R41 receptor. Compounds identified as modulators of the response of the receptor TAS2R41 may be used to decrease or mask the bitter taste of... Agent: Givaudan S.a.

20130115625 - Novel protein and use thereof: A protein being the following (A), (B), or (C): (A) a protein represented by the amino acid sequence of SEQ ID NO: 1; (B) a protein represented by an amino acid sequence in which one or a plurality of amino acid is substituted, deleted, inserted or added in the amino... Agent: Ochanomizu University

20130115623 - Use of markers of undifferentiated pluripotent stem cells: The disclosure relates to methods of binding and identifying undifferentiated pluripotent stem cells and particularly, although not exclusively, to use of binding moieties which bind to PHB on the surface of undifferentiated pluripotent stem cells, such as PHB-binding peptides, and to methods for depleting undifferentiated stem cells from a sample.... Agent: Agency For Science, Technology And Research

20130115628 - Method for selection of chemotherapeutic agents for adenocarcinoma cancer: The subject invention relates to determining the presence and level of hENT1 expression in tumor tissue that is appropriate for gemcitabine therapy, and more importantly, the level of hENT1 expression that signifies that treatment with a gemcitabine derivative is a more appropriate strategy.... Agent: Clovis Oncology, Inc.

20130115629 - Methods of breast cancer detection: Methods of diagnosing breast cancers are provided. The methods include analyzing the expression patterns of biomarkers in a plurality of cells to distinguish between invasive and non-invasive cancers, usual and atypical hyperplasias, and basal-like breast cancers. Breast cancers are diagnosed based upon different combinations of the biomarkers found in nipple... Agent: Atossa Genetics, Inc.

20130115630 - Automated multiplex immunoassay: Embodiments relate generally to an automated multiplex immunoassay for qualitatively and/or quantitatively detecting a plurality of targets on a tissue sample. Kits and apparatuses for practicing such assays are also provided.... Agent:

20130115621 - Highly sensitive immunoassays and antibodies for detection of blood factor viii: Disclosed are antibodies that selectively bind to blood coagulation factor FVIII, and highly sensitive immunological assays comprising these antibodies. Preferred assays can detect FVIII at about 3500-fold below the normal physiological levels, and have a wide array of applications including accurate monitoring of FVIII concentration in pharmaceutical products for treatment... Agent: The University Of Vermont And State Agriculture College

20130115622 - Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis: Provided are a prophylactic and therapeutic agent for amyotrophic lateral sclerosis containing an HMG-CoA reductase inhibitor and a method of screening for a prophylactic and therapeutic drug for amyotrophic lateral sclerosis using an induced pluripotent stem cell derived from a patient with amyotrophic lateral sclerosis.... Agent: Kyoto University

20130115637 - Efficiency of prion conversion in vitro and sensitivity of prion detection: The present invention relates to improved methods and kits for the amplification detection of pathogenic prion proteins in samples. In some aspects of the invention, the method comprises: i) contacting the sample with a source of PrPC to make a reaction mixture; ii) incubating the reaction mixture; iii) agitating the... Agent: University Of Maryland, Baltimore

20130115635 - Epitope tag for affinity-based applications: Described is an epitope tag useful in affinity-based applications. The invention further includes fusion proteins, methods for preparing fusion proteins, nucleic acid molecules encoding these fusion proteins and recombinant host cells that contain these nucleic acid molecules. The invention also relates to nanobodies and other affinity ligands specifically recognizing the... Agent:

20130115632 - Highly sensitive method for assaying troponin i: A highly sensitive method of assaying an analyte present in a sample using protamine is provided, as well as an immunoassay reagent and biosensor that reduces non-specific binding by electrostatic interaction of protamine with fibrinogen present in the sample.... Agent: Samsung Electronics Co., Ltd.

20130115636 - Histone citrullinated peptides and uses thereof: The present invention refers to citrullinated synthetic peptides derived from the histone H4 protein and their use in the diagnosis of autoimmune diseases,particularly Rheumatoid Arthritis (RA).... Agent: Toscana Biomarkers S.r.l.

20130115633 - Methods & devices for diagnosing cardiac disorders: A method for diagnosing a cardiac disorder by detecting levels of cardiac-specific membrane polypeptides in tissue samples.... Agent: St. George's Healthcare Nhs Trust

20130115631 - Methods for measuring high molecular weight complexes of fibrinogen with fibronectin and fibulin-1: A method of detecting MSDX Complex-1, the method introducing a first antibody to a sample to create an antibody-sample mixture, wherein the first antibody is specific for one of fibrinogen, fibronectin, or fibulin-1, the first antibody having a label molecule; providing a well coated with a second antibody, the second... Agent:

20130115634 - Peptides and methods for the detection of lyme disease antibodies: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for... Agent: Abaxis, Inc.

20130115638 - Method and rapid test for determining the fertility of sperm: The present invention concerns a procedure and a device to determine the concentration of protamine-1 and protamine-2 and the ratio between protamine-1 and protamine-2 as protamine/protein ratio in a questionable sample from an individual to be examined in order to assess the fertility of the sperm in vitro. This assessment... Agent: Justus-liebig-universitaet Giessen

20130115640 - Acth for treatment of kidney disease: Provided herein are methods for prophylactic treatment of Diabetes Mellitus comprising administration of adrenocorticotropic hormone (ACTH), or fragment, analog, complex or aggregate thereof, or any combination thereof, to an individual suspected of having, predisposed to, or at risk of developing Diabetes Mellitus. Also provided herein are methods for monitoring treatment... Agent:

20130115639 - Method for detecting a salmonella infection: o

20130115641 - Isolated luciferases and the use thereof: The invention relates to the nucleotide and amino acid sequences, and to the activity and use, of the luciferases LuAL, Lu164, Lu16, Lu39, Lu45, Lu52 and Lu22.... Agent: Bayer Intellectual Property Gmbh

20130115642 - Method for screening diabetes treating agent: The present invention provides a method for screening a diabetes treating agent comprising the following steps: (a) preparing cells inside a culture medium; (b) treating the culture medium with a test substance; (c) treating the result of step (b) with a glucose derivative which is not metabolized; and (d) measuring... Agent: Gwangju Institute Of Science And Technology

20130115643 - Colorimetric device for detecting, in an aqueous solution of interest, hydrolytic enzymatic activity with regard to at least one polymer of interest: e

20130115644 - Mass spectrometry method for measuring thiamine in body fluid: Provided are methods for determining the amount of total thiamine in a body fluid sample using liquid chromatography and mass spectrometry. Total thiamine is converted to free thiamine by treatment with an acid phosphatase prior to thiamine separation and quantification.... Agent: Quest Diagnostics Investments Incorporated

20130115645 - Fgl-2 prothrombinase as a diagnostic tool for malignancy: The present: invention reveals a strong correlation between FGL-2 prothrombinase activity levels and the presence of a malignant proliferative disorder in a subject. Thus, the present invention provides FGL-2 prothrombinase activity as a diagnostic tool for malignancy.... Agent: Mor Research Applications Ltd.

20130115646 - Method for measuring glycated hemoglobin: It is to provide a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising: reacting glycated hemoglobin in the hemoglobin-containing sample with a proteolytic enzyme in the presence of at least one salt selected from the group consisting of a pyridinium salt, a phosphonium salt, an imidazolium salt, and... Agent: Kyowa Medex Co., Ltd.

20130115651 - Fluorescent dyes: The present invention provides dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides... Agent: Enzo Biochem, Inc.

20130115650 - Isotopic biomarkers for rapid assessment of bone mineral balance in biomedical applications: The present invention relates to the use of natural isotopes 44Ca/42Ca87Sr/86Sr as biomarkers to measure changes in bone mineral balance and loss.... Agent: Arizona Board Of Regents, A Body Corporate Of The State Of Arizona

20130115648 - Method of identifying prebiotics and compositions containing the same: A high-throughput, tiered screening method of indentifying test agents that exhibit prebiotic activity on human skin commensal microorganisms and cosmetic compositions that include such agents. The method includes determining the metabolite level of a culture and comparing the metabolite level to a control value. The assay further comprises performing a... Agent: The Procter & Gamble Company

20130115647 - Method to increase the number of detectable photons during the imaging of a biological marker: The present invention relates a method to determine the presence of a photon producing biological marker in a cell, tissue or organism of interest. The method is based on Fluorescence by Unbound Excitation from Luminescence (FUEL) and comprises the steps of a) providing conditions suitable for the biological marker to... Agent: Institut Pasteur

20130115649 - Methods and reagents for metabolomics and histology in a biological sample and a kit for the same: A method of extracting and measuring one or more biochemicals from a biological sample, comprises immersing the biological sample in an organic solvent, whereby one or more biochemicals present in the biological sample are extracted into the organic solvent; separating the biological sample from the free organic solvent; and measuring... Agent:

20130115652 - Tissue array production method: In the tissue array production method in which roll-shaped tissue pieces 6 formed by rolling sheet-like tissue pieces 8 in the shape of a roll are arranged on a substrate in an array form, the tissue array is produced by placing a holding member 16 which holds a plurality of... Agent: Sakura Seiki Co., Ltd.

20130115654 - Method for producing biobased chemicals from agricultural biomass: A method for utilizing agricultural biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from agricultural biomass for producing derivative products while minimizing waste products.... Agent: Thesis Chemistry, LLC

20130115653 - Method for producing biobased chemicals from woody biomass: A method for utilizing woody biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from woody biomass for producing derivative products while minimizing waste products.... Agent: Thesis Chemistry, LLC

20130115655 - Method for the production of a lysate used for cell-free protein biosyntheses: The invention relates to a method for producing a lysate used for cell-fee protein biosynthesis, comprising the following steps: a) a genomic sequence in an organism, which codes for an essential translation product that reduces the yield of cell-fee protein biosynthesis, is replaced by the foreign DNA located under a... Agent: Rina-netzwerk Rna Technologien Gmbh

20130115656 - Engineered yeast cells and uses thereof: The present application provides engineered yeast cells and uses thereof. In specific embodiments, the yeast cells have a mutation in the GAL2 gene. In specific embodiments, the yeast cells can be used for producing a protein or compound of interest.... Agent: California Institute Of Technology

20130115657 - Humanized anti-cd19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease: The present invention provides chimeric and humanized versions of anti-CD19 mouse monoclonal antibodies. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human CD19 antigen and that may mediate ADCC, CDC, and/or apoptosis for the treatment of B cell diseases and... Agent: Medimmune, LLC.

20130115658 - Reversible, parallel and multitask cloning method and kit: The present invention is related to integrated method and tools to construct recombinant DNA molecules (to be used as DNA vaccine or gene therapy) without requiring the use of antibiotic(s) resistance gene(s) and without requiring the addition of one or more antibiotic(s) to the culture medium of cells submitted to... Agent:

20130115659 - Compositions and methods for grain processing without ph adjustment: Described are compositions and methods relating to starch processing without a phytase pretreatment step and without adjustment of the slurry pH adjustment.... Agent: Danisco US Inc.

20130115660 - Method of producing sugar: Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms comprising a non-gelatinous, solid cultivation support suitable for providing nutrients and moisture to photosynthetic microorganisms and a physical barrier covering at least a portion of the surface of... Agent: Proterro, Inc.

20130115661 - Method for producing biobased chemicals from cultivated plant biomass: A method for utilizing cultivated plant biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from cultivated plant biomass for producing derivative products while minimizing waste products.... Agent: Thesis Chemistry, LLC

20130115662 - Fungal peroxygenases and methods of application: The invention relates to polypeptides having peroxygenase activity and compositions comprising such polypeptides, their encoding polynucleotides, expression vectors and recombinant host cells comprising such polynucleotides or vectors, methods of producing the polypeptides, as well as methods of application and uses thereof, including a process for enzymatic, regioselective oxygenation of N-heterocycles... Agent: Novozymes A/s

20130115663 - Enone reductases: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.... Agent: Codexis, Inc.

20130115666 - Method for production of euglena containing wax ester at high cotent, and method for production of wax ester: e

20130115665 - Methods and compositions for producing fatty alcohols: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.... Agent: Ls9, Inc.

20130115664 - Process and system for producing algal oil: A method for producing an algal oil is provided. The method includes continuously providing a growth medium and an algal strain to a bioreactor at a predetermined fluid flow rate; illuminating the growth medium and algal strain contained within the bioreactor by a first artificial light source for a time... Agent: Bard Holding, Inc.

20130115667 - Amycolatopsis sp. strain and methods of using the same for vanillin production: This invention provides an Amycolatopsis sp. strain (zhp06), and a method of using the whole cell preparation of the strain for vanillin production. The strain was deposited in China Center for Type Culture Collection on Jul. 26, 2011 with the number of CCTCC NO: M 2011265. Under high concentrations of... Agent:

20130115668 - Host cells and methods for producing fatty acid derived compounds: The present invention provides for a method of producing one or more fatty acid derived compounds in a genetically modified host cell which does not naturally produce the one or more derived fatty acid derived compounds. The invention provides for the biosynthesis of fatty acid derived compounds such as C18... Agent: The Regents Of The University Of California

20130115669 - Bioprocessing ligno-cellulose into ethanol with recombinant clostridium: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell... Agent: L'universit&#xe9 De La Mediterran&#xe9 E

20130115670 - Cell disruption: A process for the disruption of a biological cell comprising freezing, boiling or perhaps alternately freezing and boiling the material containing the biological cell using a thermoelectric cell a base face whereof is contiguous with a heat sink/source held at a substantially constant temperature and a working face . Apparatus... Agent:

20130115671 - Enzymes from conidiobolus brefeldianus and process for preparation thereof: The instant invention relates to a fungus of the Conidiobolus species bearing accession number MTCC 5185. The invention further relates to the process for preparing an enzyme mix of proteases, carbohydrases, and lipases for the Conidiobolus species. Such enzymes find use in the leather, silk and other industries.... Agent: Council Of Scientific And Industrial Research

20130115672 - Biological composite and method for reducing h2s: A biological composite and method for reducing H2S are disclosed. The biological composite for reducing H2S includes a carrier and Thermus sp. immobilized on the carrier. Therefore, if a sample containing H2S has contact with Thermus sp. or the carrier with Thermus sp. immobilized thereon, the amount of H2S can... Agent: National Chiao Tung University

20130115673 - Methods of screening embryonic progenitor cell lines: Aspects of the present invention include methods and compositions related to the production and use of numerous clonal lineages of embryonic progenitor cell lines derived from differentiating cultures of primordial stem cells with diverse molecular markers and having been cultured for >21 doublings of clonal expansion. The robustness of these... Agent: Biotime, Inc.

20130115674 - Human monoclonal antibodies to human nucleolin: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the... Agent: Musc Foundation For Research Development

20130115675 - Dehalogenases, nucleic acids encoding them and methods for making and using them: The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature.... Agent: Verenium Corporation

20130115676 - High fidelity restriction endonucleases: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction... Agent: New England Biolabs, Inc.

20130115677 - High fidelity restriction endonucleases: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction... Agent: New England Biolabs, Inc.

20130115678 - High fidelity restriction endonucleases: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction... Agent: New England Biolabs, Inc.

20130115679 - High fidelity restriction endonucleases: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction... Agent: New England Biolabs, Inc.

20130115680 - High fidelity restriction endonucleases: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction... Agent: New England Biolabs, Inc.

20130115681 - High fidelity restriction endonucleases: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions includes restriction... Agent: New England Biolabs, Inc.

20130115682 - Fusion proteins: The invention provides a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a target cell; a Targeting Moiety that is capable of binding to a Binding Site on... Agent: Syntaxin, Limited

20130115683 - Method for the preparation of a pharmaceutical composition: The present invention relates to a method for the preparation of a pharmaceutical composition for the prevention or/and treatment of an influenza virus infection.... Agent: Max-planck-gesellschaft Zur Foerderung Der Wissenschaften E.v.

20130115684 - Methods and systems for reduction of halogenated compounds: Methods and systems for dehalogenating organohalides are disclosed. In one respect, the systems can generate hydrogen in an electrolysis cell and supply the hydrogen to anaerobic dehalogenating bacteria to decontaminate organohalides at a contamination site.... Agent:

20130115686 - Method of manufacturing micro chamber plate with built-in sample and analytic micro chamber plate, analytic micro chamber plate and apparatus set for manufacturing analytic micro chamber plate with built-in sample: The present invention relates to a micro chamber plate, and more particularly, to an analytic micro chamber plate in which a plurality of reaction solutions including a primer or probe selectively reacting with a nucleic acid react with each other without cross-contamination to measure and analyze a fluorescence level in... Agent: Bioneer Corporation

20130115685 - Point-of-care fluidic systems and uses thereof: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.... Agent:

20130115687 - Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of dna: The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials... Agent: University Of South Florida

20130115688 - Laminar photobioreactor for the production of microalgae: A modular photobioreactor for the production of microalgae particularly suited for absorber emission gases with a high carbon dioxide (CO2) content. It is based on the continuous recirculation of a microalgae-containing liquid medium through sheets of fabric facilitating CO2 absorption and microalgae illumination. The photobioreactor enables supplying the gases to... Agent: Universidad Politecnica De Madrid

20130115689 - Photobioreactor: Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms comprising a non-gelatinous, solid cultivation support suitable for providing nutrients and moisture to photosynthetic microorganisms and a physical barrier covering at least a portion of the surface of... Agent: Proterro, Inc.

20130115690 - Cell culture vessel and cell culture device: Disclosed is a cell culture vessel that can prevent liquid leakage from the cell culture space and entry of particles containing microorganisms from outside the cell culture space, and that can prepare regenerated tissue in a manner that is safe and results in peace of mind. The cell culture vessel... Agent: Hitachi, Ltd.

20130115691 - Thermo-conductive cell culture dish holder: The present invention describes various devices for holding cell culture dishes in a secure manner and to ensure rapid and uniform heat transfer to and from the cell culture dish.... Agent: Biocision, LLC

20130115693 - Device for isolation and/or purification of biomolecules: The present invention refers to a device, comprising a hollow body having at least one open end comprising at least one solid matrix binding, adsorbing, absorbing, chelating or retaining compounds which are not desired in a sample and preferably at least one barrier which is non-permeable for liquids and solids... Agent:

20130115692 - Methods and compositions relating to improved lentiviral vectors and their applications: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise a self-inactivating configuration for biosafety and promoters such as the... Agent: Research Development Foundation

20130115694 - Formation of neuromuscular junctions in a defined system: A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more human muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a human muscle... Agent: University Of Central Florida Research Foundation, Inc.

20130115695 - Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.... Agent: Viacyte, Inc.

20130115696 - Sirna that inhibits wt1 gene expression and uses thereof: The present inventors discovered that siRNAs targeting the 17AA site of the WT1 gene not only suppress the expression of the WT1 gene, but also demonstrate remarkable cell growth-suppressing effects and cell death-inducing effects in cancer cell lines.... Agent:

20130115697 - Methods and apparatus for enhanced recovery of cells from tissue samples: This document describes methods and an apparatus for recovery of cells from a tissue sample. In some embodiments, at least two rounds of acceleration and deceleration are performed.... Agent:

20130115698 - Methods and combination: A method and a combination for the cultivation of eukaryotic cells are provided, as well as a method for preparation of eukaryotic cells. The methods comprise providing a sample of eukaryotic cells to be cultured, applying said sample to a cell scaffold material; and maintaining said cell scaffold material having... Agent: Spiber Technologies Ab

20130115699 - Polyplex gene delivery vectors: Compositions comprising linear PNAI, cyclic PNAI, linear PEI, and/or cyclic PEI, useful for delivering compounds or substances into a cell, are provided, as well as methods of making linear PNAI, cyclic PNAI, linear PEI, and cyclic PEI. Also provided are methods of using compositions comprising linear PNAI, cyclic PNAI, linear... Agent: The Administrators Of The Tulane Educational Fund

20130115700 - Method for transfecting nucleic acid to cell and nucleic acid complex: A method for transacting nucleic acid to cell comprising a step for forming a nucleic acid complex by bringing a double-stranded nucleic acid molecule into contact with a nucleic acid carrier having an amino acid sequence of alternating a basic amino acid and a hydrophobic amino acid, which has a... Agent: Kitakyushu Foundation For The Advancement Of Industry Science And Technology

20130115701 - Transgenic photosynthetic microorganisms: Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms comprising a non-gelatinous, solid cultivation support suitable for providing nutrients and moisture to photosynthetic microorganisms and a physical barrier covering at least a portion of the surface of... Agent: Proterro, Inc.

20130115702 - Transgenic photosynthetic microorganisms: Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms comprising a non-gelatinous, solid cultivation support suitable for providing nutrients and moisture to photosynthetic microorganisms and a physical barrier covering at least a portion of the surface of... Agent: Proterro, Inc.

20130109006 - Apparatus and method for maintaining and/or restoring viability of organs: Methods of monitoring, maintaining, and/or restoring viability of at least one organ in at least one device selected from an organ transporter, perfusion apparatus, cassette, and organ diagnostic apparatus, the methods including monitoring data comprising information relating to events occurring while at least one organ is present in at least... Agent: Lifeline Scientific, Inc.

20130109007 - Bioreactor and method for creating and/or conditioning biological tissues: Disclosed herein is a bioreactor (12) for creating and/or conditioning biological tissues and in particular artificial heart valves, vascular grafts and/or cardiovascular patches. The bioreactor (12) comprises a bioreactor housing (30, 32) having a first section (42) and a second section (54), said first section (42) being adapted to receive... Agent: Ludwig-maximilians-universit&#xc4 T M&#xdc Nchen

20130109008 - Method and apparatus for growing photosynthetic organisms: A biological cultivation system for the culture of photosynthetic organisms including at least one cultivation chamber permitting exposure of the culture medium to natural and/or artificial light and including; a light transmissive wall or walls defining a gas space; and a culture medium containment area below the gas space; one... Agent: Mbd Energy Limited

20130109009 - Biological sample preparation: A biological sample collection and preparation kit includes a container-closure combination and collector including a handle, screen, and probe. The screen includes tapered apertures for separating sample debris from sample constituents collected via floatation. The probe is combined with the handle and screen to provide a disposable collector for safe... Agent:

20130109010 - Method for detection of infection with human cytomegalovirus: A novel means by which HCMV infection can be detected with a high sensitivity and whose practicality is high is disclosed. The present inventors synthesized as many as 15 kinds of HCMV proteins in their full length forms, and intensively studied their reactivities with sera from HCMV-infected patients to find... Agent: Fujirebio Inc.

20130109012 - Device to expose cells to fluid shear forces and associated systems and methods: The present technology relates generally to devices to expose cells to fluid shear forces and associated systems and methods. In particular, several embodiments are directed toward devices to expose cells to fluid shear forces in order to measure changes in internal cell forces. In some embodiments, a fluidic device includes... Agent: University Of Washington Center For Commercialization

20130109011 - Methods of and devices for capturing circulating tumor cells: A device and methods are provided for efficient and quick capture of target cells through a main microchannel having capture elements immobilized thereon and manipulating a velocity profile of a sample as it passes through the main microchannel. The cell capture device may have a main microchannel with a depth... Agent: Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College

20130109014 - Automatic system for detection and identification of isolated cells from blood or tissue: A non-invasive method for determining the developmental age of a fetus or detecting cancer cells in a sample is provided. The method utilizes, for example, a sample of blood from a pregnant female and telomeric nucleic acid probes.... Agent: Ikonisys, Inc.

20130109019 - Hapten conjugates for target detection: Embodiments of hapten conjugates including a hapten, an optional linker, and a peroxidase-activatable aryl moiety are disclosed. In some embodiments, the peroxidase-activatable aryl moiety is tyramine or a tyramine derivative. Embodiments of methods for making and using the hapten conjugates also are disclosed. In particular embodiments, the hapten conjugates are... Agent:

20130109018 - Methods and compositions for detection and enrichment of target small rnas: Methods and compositions are provided for detecting small target RNAs where the target RNA may be single-stranded or double-stranded and may be contained in a mixture of RNAs of different types and sizes. The methods and compositions utilize a p19 fusion protein that is capable of binding double-stranded RNA in... Agent: New England Biolabs, Inc.

20130109017 - Multiple myeloma prognosis and treatment: Disclosed herein are diagnostic and prognostic methods for determining the overall survival, and therapeutic regimes, for multiple myeloma patients. The methods involve the detection of PTHR1 gene expression alone or in combination with other clinical factors. The tests are suitable for diagnosing and monitoring treatment of patients having or suspected... Agent: University Of Utah Research Foundation

20130109016 - Primer composition for amplifying a gene region having various variations in a target gene: The present invention provides a primer composition for amplifying a gene region having various variations in a target gene comprising: a first primer group comprising at least one primer specific to at least one template including a genotype-analyzable sequence of a genetically variant base sequence subjected to be analyzed in... Agent: Genematrix Inc.

20130109013 - Probe and primer for tubercle bacillus detection, and method of detecting human tubercle bacillus therewith: An object of the present invention is to provide a novel primer and prove for detecting tubercle bacillus capable of avoiding false positive, and an easy-to-use, rapid and high-sensitivity method for detecting human tubercle bacillus (Mycobacterium tuberculosis) using the same. The present invention relates to an oligonucleotide comprising a part... Agent: Wako Pure Chemical Industries, Ltd.

20130109015 - Single nucleotide polymorphisms associated with left ventricular hypertrophy and use thereof: The present invention relates to single nucleotide polymorphisms associated with left ventricular hypertrophy and use thereof. The present invention provides a convenient and high reliable in vitro diagnosis system for left ventricular hypertrophy and cardiovascular diseases.... Agent: Industry-academic Cooperation Foundatin, Yonsei University

20130109026 - Interference control panel for evaluation of analytical assays for samples derived from blood: The invention relates to quality control of analytical assays, particularly NAT assays of blood samples containing nucleic acids. A control panel containing quantified amounts of substances known to interfere with an analytical assay is used and compared with a reference sample in the analytical assay. A comparison of the assay... Agent: Life Technologies Corporation

20130109023 - Method and composition for nucleic acid amplification: The present teachings provide methods, compositions, and kits for nucleic acid amplification. In some embodiments of the present teachings, amplification reactions are performed with at least one high stability primer. In some embodiments, the present teachings provide a method comprising a high stability primer for amplification of a nucleic acid... Agent: Applied Biosystems LLC

20130109024 - Obtaining analytes from a tissue specimen: A method of obtaining for analysis one or more analytes of diagnostic interest from a tissue specimen having an identified area of diagnostic interest in a two-dimensional spatial location, comprising contacting the identified area of diagnostic interest with a contact medium, effecting at least partial transfer of the one or... Agent:

20130109025 - Prevention of crystal formation in liquid solutions during storage by adding a betaine: The present invention relates to the field of improving and stabilizing concentrated solutions and in particular to improving and stabilizing concentrated solutions for the extraction of nucleic acids from sample material. Thus, the present invention, further, relates to the field of molecular biology. The present invention describes the use of... Agent:

20130109027 - Procedure for the specific isolation of total dna content of bacterial germs and a kit for this purpose: Procedure for the specific isolation of total DNA content of bacterial germs of different samples, in the course of which the cells are lysated, the DNA content of the lysate is bound selectively, it is washed and then the desalinated linear polymer nucleic acid is eluted from the binding surface... Agent:

20130109022 - Three-stage thermal convection apparatus and uses thereof: Disclosed is a multi-stage thermal convection apparatus and uses thereof. In one embodiment, the invention features a three-stage thermal convection apparatus that includes a temperature shaping element for assisting a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without... Agent: Ahram Biosystems, Inc.

20130109021 - Two-stage thermal convection apparatus and uses thereof: Disclosed is a multi-stage thermal convection apparatus such as a two-stage thermal convection apparatus and uses thereof. In one embodiment, the two-stage thermal convection apparatus includes a temperature shaping element that assists a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying... Agent: Ahram Biosystems, Inc.

20130109020 - Use of an isoform of hla-g as an osteogenesis marker: The invention relates to the use of at least one isoform of HLA-G as a marker for assessing osteogenesis in mammals.... Agent: Commissariat A L'energie Atomique Et Aux Energies Alternatives

20130109028 - Vector, vector combinations, methods and kit thereof: The disclosure relates to a method of identification of antiviral molecules that help in efficient viral control and thereby aid in disease management. In particular, the disclosure relates to identification of anti-Tat molecules and hence is directed towards antiviral drug development. The disclosure also relates to Tat-inducible GFP-anti RFP shRNA... Agent: Jawaharlal Nehru Centre For Advanced Scientfic Research

20130109030 - Examination system with sample incubation: The invention relates to a cartridge(10) and its use in an examination apparatus(100). A sample(1) can be introduced into an inlet(11) of the cartridge(10) and conducted through a channel(12) to a reaction chamber(13). In the reaction chamber(13), an examination of the sample takes place, for example by frustrated total internal... Agent: Koninklijke Philips Electronics N.v.

20130109029 - Methods and compositions for cellular imaging and cancer cell detection using light harvesting conjugated polymer-biomolecular conjugates: The present invention relates to conjugated polyelectrolyte (CPE) or oligoelectrolyte (COE) compounds represented by general structural formulae (I)-(IV), or a salt thereof and methods of using these compounds to detect targets in samples. In particular, the methods include: (1) exposing a sample to a compound of structural formula (I), (II)... Agent: National University Of Singapore

20130109032 - Use of biomarkers for assessing treatment of gastrointestinal inflammatory disorders with beta7 integrin antagonists: The present invention is directed to methods of using biomarkers to assess treatment of gastrointestinal inflammatory disorders with beta7 antagonists. More particularly, the present invention relates to methods of using the level of gut-homing lymphocytes in peripheral blood, the level of drug occupancy on gut-homing lymphocytes, and/or the level of... Agent: Genentech, Inc.

20130109031 - Inhibitor scaffold for the inhibition of the enzyme phosphoenolpyruvate carboxykinase: A PEPCK inhibitor can include identifying a molecule that has a size capable of fitting into and interacting with the PEPCK binding site and at least one of the following: (a) a first terminal substituent having co-planar atoms acting as metal ligands to the active site metal ion PEPCK; (b)... Agent: University Of Kansas

20130109034 - Compositions and methods for determining celiac disease: Provided are compositions and methods for diagnosis of celiac disease. The compositions include recombinant proteins that contain tissue transglutaminase and deamidated gliadin sequences. The gliadin sequences are repeated in the recombinant proteins. Also provided is a method for identifying an individual as having celiac disease based on the presence of... Agent: Immco Diagnostics, Inc.

20130109035 - Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma: The present invention relates to diagnostic, prognostic and clinical methods of distinguishing high-risk IPMN from more benign IPMN as well as high-grade PanIN and PDAC from low-grade PanIN with moderate sensitivity and very high specificity using Das-1 and related antibodies.... Agent: University Of Medicine And Dentistry Of New Jersey

20130109033 - Method, particularly enzyme-linked immunosorbent assay (elisa), for in vitro detection of amyloid beta autoantibodies, microtiter plate, and test kit: A method, particularly an enzyme-linked immunosorbent assay (ELISA), for the in-vitro detection of Aβ autoantibodies in human serum and/or plasma contains the following steps: preparing an antigen-coated solid phase; incubating the solid phase with a blocking solution; incubating the solid phase with a sample to be examined; immunological detection of... Agent: Philipps-universitat Marvurg

20130109036 - Protein substrate and its manufacturing method: A protein substrate includes a base having micro-passages and reaction grooves, a polyethyleneimine (PEI) fixed on the base and a specific protein fixed on the PEI. The base is modified by plasma stripper to make the PEI bonded on the base. Mixed with tyrosinase, the specific protein can stably stick... Agent: National Formosa University

20130109037 - Methods for detecting adenosine monophosphate in biological samples: The present invention provides compositions and methods to detect and/or determine the amount and/or presence of adenosine monophosphate (AMP) in biological samples. The method comprises converting substantially all AMP in the solution to adenosine diphosphate (ADP) using a first enzyme, suitably polyphosphate:AMP phosphotransferase (PAP), that is capable of converting AMP... Agent: Promega Corporation

20130109038 - Analytical instrument and analytical method: Provided are an analytical instrument and an analytical method that allow for the direct analysis of a target substance in an undiluted specimen by a transmission photometry in a tightly closed cell container space. An analytical instrument is an analytical instrument for analyzing a target substance contained in a specimen... Agent: Arkray, Inc.

20130109040 - In vitro point-of-care sensor and method of use: An in vitro sensor for point-of-care detection of at least one analyte or reaction product includes an inert, impermeable substrate, a sensing system, and a reference system. The substrate includes a first transparent surface oppositely disposed from a second surface and first and second cavities. Each of the first and... Agent: Case Western Reserve University

20130109039 - Methods and materials for modulating start-up time and air removal in dry sensors: The invention relates to sensors configured to include compositions disposed in specific regions of the sensor in order to provide the sensors with enhanced functional properties, for example faster start-up times. These compositions include, for example, hygroscopic compositions, gas generating compositions and gas solvating compositions. While typical embodiments of the... Agent: Medtronic Minimed, Inc.

20130109041 - Fast screening of clones: The invention relates to a method of fast identification and isolation of cells featuring a desired phenotype. The phenotype is coupled to the amount of gas-liberating enzymes or increased growth. The cells are encapsulated into microcapsules allowing exchange of solvents through the microcapsule wall, but retaining some or all of... Agent:

20130109043 - Method for inspecting gastroenterological cancer by utilizing n-linked sugar chain: As a result of collecting blood from pancreatic cancer patients, esophageal cancer patients, and stomach cancer patients, and conducting mass spectrometry on N-linked sugar chains in the plasmas, sugar chains whose abundances are significantly different from those of healthy subjects have been successfully identified from the blood samples of the... Agent: Sumitomo Bakelite Co., Ltd.

20130109042 - Sample containers adapted for acoustic ejections and sample preservation and methods thereof: Sample container for holding and transferring a liquid sample and method thereof. The sample container includes an inlet configured to allow a liquid sample to enter a sample container, and an outlet configured to allow one or more droplets of the liquid sample to exit the sample container by one... Agent: Labcyte Inc.

20130109048 - Method for in-vitro monitoring of neuronal disorders and use thereof: The present invention relates to methods and neuronal cellular preparations allowing monitoring intracellular and transcellular molecular events on both short and long timescales in an ex vivo neuronal network of intact post-mitotic neurons. In particular, the invention relates to methods, kits, genetically engineered neuronal cells, preparations and uses thereof allowing... Agent: Ecole Polytechnique Federale De Lausanne (epfl)

20130109047 - Method of sampling and/or depositing a sample of biological matter and device implementing such a method: The aim of the present invention is a method of sampling all or part of a sample (11) of biological matter (7), which is crude, enriched or cultured through contact with a culture medium (8), such as agar, for example in a Petri dish, using a probe (3) equipped with... Agent: Biomerieux S.a.

20130109046 - Methods for detecting sulfhydryl-containing compounds in a biological test sample: e

20130109045 - Methods of identifying hsp90 inhibitors with less ocular toxicity: Provided is a method of identifying Hsp90 inhibitors with substantially less ocular toxicity or with substantially improved ocular toxicity profile. The method comprises measuring the respective concentrations of an Hsp90 inhibitor in the retina and plasma at certain time points following the administration of the Hsp90 inhibitor in a subject,... Agent: Synta Pharmaceuticals Corp.

20130109044 - Quantification method for total amount of microalgal lipids by near-infrared raman spectrometry: A quantification method for a total amount of microalgal lipids by near-infrared Raman spectrometry is disclosed, which includes the following steps: providing a microalgae sample and a substrate of which a surface is covered by a metal layer; applying the microalgae sample on the metal layer of the substrate; supplying... Agent:

20130109049 - Method of establishing a fungal nail infection: The present invention provides a method of infecting a nail fragment with a fungus, to form an infected nail fragment comprising at least 1×102 fungal colony forming units (cfu) per cm2 of the infected surface(s). There is also provided a method of assessing the efficacy of potential therapeutic compounds in... Agent: Novabiotics Limited

20130109051 - Method for detecting microorganisms, device for detecting microorganisms and program: A method for detecting microorganisms, which comprises: a training step for forming, by a classifier, feature vectors based on color data on individual points within a subject region of training in a culture medium, mapping the points in the culture medium, that are specified by the feature vectors, on a... Agent: Kabushiki Kaisha Yakult Honsha

20130109050 - Microbead kit and method for quantitative calibration and performance monitoring of a fluorescence instrument: Fluorescently labeled microsphere calibration and quality control particles for use in establishing standardized fluorescence detector setup, monitoring daily QC of flow cytometers and quantitative calibration of the fluorescence detectors in traceable units of measure (molecules equivalent soluble fluorescence; MESF).... Agent: Nodality, Inc.

20130109052 - Sterility test method and totally enclosed bacterial ampoule incubator used by it: A sterility test method includes: selecting strain and culture medium, preparing bacterial cultures, transcribing fingerprint characteristics in thermograms as indices to verify the characteristics, drawing the thermodynamic parameters of the thermogram, determining the positive judgment index and performing sterility test for the samples. A fully-enclosed bacteria collecting ampoule incubator includes... Agent: 302 Military Hospital Of China

20130109053 - Genetically modified t cell receptor mice: The invention provides a genetically modified non-human animal that comprises in its genome unrearranged T cell receptor variable gene loci, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified non-human animal and methods of making the same. Various methods of... Agent: Regeneron Pharmaceuticals, Inc.

20130109055 - Use of mammalian promoters in filamentous fungi: The present disclosure is directed to the use of mammalian promoters to drive recombinant expression in filamentous fungal cells. In certain aspects, the present disclosure provides an expression cassette useful for the expression of polypeptide in filamentous fungal cells. Also provided herein, are vectors and recombinant filamentous fungal cells comprising... Agent: Bp Corporation North America Inc.

20130109054 - Use of plant promoters in filamentous fungi: The present disclosure is directed to the use of plant promoters to drive recombinant expression in filamentous fungal cells. In certain aspects, the present disclosure provides an expression cassette useful for the expression of polypeptide in filamentous fungal cells. Also provided herein, are vectors and recombinant filamentous fungal cells comprising... Agent: Bp Corporation North America Inc.

20130109056 - Immunoglobulin aggregate removal: For the removal of high molecular weight compounds from recombinantly produced polypeptides generally chromatographic methods are employed. It has been found that underivatized controlled pore glass (uCPG) selectively binds high molecular weight compounds present in a solution. The purified polypeptide can be recovered e.g. from the flow through of a... Agent: F. Hoffmann-la Roche Ag

20130109057 - Method for immunizing animal, composition for immunization, method for producing antibody, method for producing hybridoma, and method for producing monoclonal antibody: It is an object of the present invention to a method whereby a humoral immune response is induced more efficiently in producing an antibody against an antigen protein by gene immunization. A fusion gene composed of a gene encoding the full-length of a part of the antigen protein or a... Agent: Sekisui Chemical Co., Ltd.

20130109058 - Polypeptide producing cells: The current invention describes a nucleic acid comprising in a 5′ to 3′ direction a) a first nucleic acid encoding a heterologous polypeptide without an in frame stop codon, b) a second nucleic acid beginning with a 5′ splice donor site and terminated by a 3′ splice acceptor site comprising... Agent: Hoffmann-la Roche Inc.

20130109059 - Method for mass production of high-purity nucleotides: Provided is a method of mass-producing high-purity nucleotides including providing a sequencing substrate having a clonal library of oligonucleotides on a solid support, sequencing the clonal library, obtaining measured location data of the solid support on the sequencing substrate, mapping pixel data of a signal generated from the solid support... Agent: Snu R&db Foundation

20130109060 - Nucleic acid amplification in the presence of modified randomers: The present invention is directed to a composition comprising a DNA Polymerase which is preferably thermostable, Deoxynucleotides, at least one primer oligonucleotide or a pair of amplification primers, and randomized 5-8 mer oligonucleotide, characterized in that said oligonucleotide comprises a modification with an organic hydrophobic moiety Such a composition is... Agent:

20130109061 - Hyperproliferative recombinant cell: A method increases the growth of a cell by a deletion or one or more mutation(s) in the tldD and/or tldE genes, coupled with one or more mutation(s) in dam or a partial deletion or deletion of the dam gene. A cell is obtained by the method and used.... Agent: Universite Libre De Bruxelles

20130109062 - Thermostable xylanase for the selective hydrolysis of pentose-containing polysaccharides: The present invention relates to polypeptides having xylanase activity and nucleic acid sequences encoding such polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides. One specific application of the xylanase is... Agent: S&#xdc D-chemie Ag

20130109063 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family: The present invention provides a method for producing L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to enhance the expression of the bssR gene, which encodes a regulator of biofilm through signal secretion.... Agent: Ajinomoto Co., Inc.

20130109064 - Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols: The invention provides non-naturally occurring microbial organisms containing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol, crotyl alcohol or 3-buten-1-ol pathways comprising at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol, crotyl alcohol or 3-buten-1-ol. The invention additionally provides methods of... Agent:

20130109065 - Sustainable conversion of citrus peel waste: A sustainable method and system for producing bio-fuels from citrus peels and the recovery of limonene and pectin prior to fermentation of the peel solids. In one embodiment a sustainable method and system for the concurrent recovery of limonene and pectin from citrus peels is disclosed. The peels are optionally... Agent:

20130109066 - Acid production by fermentation: The invention provides methods for producing Lactate by anaerobic Fermentation. According to particular methods of the invention, Lactate is produced by anaerobic fermentation of a substrate comprising hydrogen and carbon monoxide.... Agent: Lanzatech New Zealand Limited

20130109067 - Method for the preparation of hydroxy acids: e

20130109068 - Methods for producing acetone, butanol, and ethanol: Methods of producing solvents from algae, where the methods include processing algae to yield processed biomass, fermenting the processed biomass with a Clostridium bacteria to yield solvents.... Agent: Utah State University

20130109069 - Microorganisms for the production of 1,4-butanediol: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.... Agent: Genomatica, Inc.

20130109070 - Transformant for enhancing bioethanol production, and method for producing ethanol by using said strain: The present invention relates to a transformant for inhibiting glycerol production through deletion of glycerol producing genes of Saccharomyces cerevisiae modified so as to use glycerol as a fermentation source, or enhancing bioethanol production through overexpression of TATA-binding proteins, SPT3 and SPT15, and a method for producing ethanol by using... Agent: Korea University Research And Business Foundation

20130109071 - Fermentation process: The present invention relates to methods of enhancing fermentation for the production of fermentation products. Specifically, the invention relates to enhancing fermentation in processes of producing ethanol from plant material using one or more fermenting organisms.... Agent: Novozymes North America, Inc.

20130109072 - Support for protein immobilization, immobilized protein, and methods for producing the same: A support for enzyme immobilization is described, which is for immobilizing enzymes of various molecular sizes and also for, due to the modification of the surface silanol groups of porous silica particles, for immobilizing various kinds of enzymes, and enables the design of an immobilized enzyme, which exhibits an activity... Agent: Jgc Corporation

20130109073 - Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (dnl) technology: The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the cytokine-MAb DNL complex comprises an IgG antibody attached to two AD (anchor domain) moieties and four cytokines, each attached to a DDD (docking and dimerization domain) moiety. The DDD moieties form dimers... Agent: Ibc Pharmaceuticals, Inc.

20130109074 - Polymer-encapsulated carbon capture liquids that tolerate precipitation of solids for increased capacity: A system for carbon dioxide capture from flue gas and other industrial gas sources utilizes microcapsules with very thin polymer shells. The contents of the microcapsules can be liquids or mixtures of liquids and solids. The microcapsules are exposed to the flue gas and other industrial gas and take up... Agent: Lawrence Livermore National Security, LLC

20130109075 - Novel herbicide resistance gene: The subject invention provides novel polynucleotides and polypeptides encoding a methyltransferase. The subject invention provides novel plants that express the methyltransferase disclosed herein and are resistant to auxin-based herbicides. The subject invention also provides transgenic plants have been transformed with one or more other herbicide resistance genes such that the... Agent: University Of Tennessee Research Foundation

20130109076 - Protein exhibiting activity of pyrethrin biosynthetic enzyme, gene encoding the protein, and vector bearing the gene: Amino acid sequences of an enzyme involved in pyrethrin biosynthesis and a base sequence of the gene thereof; constructing vectors bearing the gene and transformants; and extractable from plant bodies producing pyrethrin by applying such creative techniques to plant bodies with faster growth aiming to provide a method to efficiently... Agent: An Educational Foundation Kinki University

20130109077 - Baculovirus-mediated transgene expression in both mammalian and insect cells: This invention relates to a method for expressing a gene in a cell. The method includes introducing into a cell an agent that inhibits one or both of miRNA pathway and antiviral defense pathway; and a baculovirus that contains a nucleic acid molecule including a gene operably linked to a... Agent: Academia Sinica

20130109078 - Methods for harvesting biomass: A method of harvesting biomass in an aqueous solution, where the method includes mixing an organic coagulant or flocculant with a solution comprising biomass and water.... Agent: Utah State University

20130109079 - Method for separating an organic component from a mixture containing the organic component: A method for separating an organic component from a mixture containing the organic component, water, and a microorganism, the method comprising (a) subjecting the mixture to a first separation step under mild conditions in order to generate a first stream containing water and organic component, and a second stream containing... Agent: Shell Oil Company

20130109080 - Integrated systems and assemblies for sample processing: Methods and devices for the thermal processing of samples are disclosed, including portable, integrated processing assemblies for occluding channels in a fluidic device.... Agent: 3m Innovative Properties Company

20130109081 - Culture apparatus for microscope viewing and method therefor: A culture apparatus for microscopic viewing enables effective microscopic viewing at high magnification of samples such as cells suspended in a culture solution while the samples are maintained at a uniform temperature. The apparatus is used to microscopically view a sample placed on a microscope stage, and is provided with... Agent: Tokai Hit Co., Ltd.

20130109082 - Device for sequentially dispensing liquid reagents to a reaction chamber: An apparatus for delivering a plurality of liquid volumes sequentially to a reaction site is provided, the apparatus comprising a vessel having a plurality of solid spacers arranged in linear order therein so as to define a series of adjacent voids, separated by individual solid spacers, for receiving said liquid... Agent: Avacta Limited

20130109083 - Device and system for counting and analysing particles and use of said system: A MIR-type device is described for determining the measurement and analysis of particles using optical means, especially particles of a suprananometric size, which can be found in a suspension injected in said device. Likewise, a particle analysis system is described that makes use of said device connected to a light... Agent: Consejo Superior De Investigaciones Cientificas (csic)

20130109084 - Closed photobioreactor system for continued daily in situ production of ethanol from genetically enhanced photosynthetic organisms with means for separation and removal of ethanol: The invention provides a device for growing genetically enhanced aquatic photoautotrophic organisms in a stable culture, causing the organisms to produce ethanol, and then separating, collecting, and removing the ethanol in situ.... Agent: Algenol Biofuels Switzerland Gmbh

20130109085 - Closed photobioreactor system for continued daily in situ production of ethanol from genetically enhanced photosynthetic organisms with means for separation and removal of ethanol: The invention provides a device for growing genetically enhanced aquatic photoautotrophic organisms in a stable culture, causing the organisms to produce ethanol, and then separating, collecting, and removing the ethanol in situ.... Agent: Algenol Biofuels Switzerland Gmbh

20130109086 - Disposable set for cell culture, cell culture device and cell preparation method: It is an object to achieve a closed system that has a simple structure without resorting to large scale equipment and that sequentially carries out all of the step of separating useful cells, the step of culturing the useful cells separated in the separation step, and the step of washing... Agent: Kaneka Corporation

20130109087 - Transgenic animal with enhanced immune response and method for the preparation thereof: The present invention provides a method for producing a transgenic (Tg) non-human animal capable of developing an enhanced humoral immune response against an antigen as compared to a non-transgenic control animal of the same species, comprising introducing into said non-human animal a genetic construct providing for enhanced MHC class I-related... Agent: Agricultural Biotechnology Center

20130109088 - Decellularization and recellularization of solid organs: The invention provides for methods and materials to decellularize a solid organ and to recellularize such a decellularized organ to thereby generate a solid organ.... Agent: Regents Of The University Of Minnesota

20130109089 - Methods for reprogramming somatic cells: The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated... Agent: Whitehead Institute For Biomedical Research

20130109090 - Methods for reprogramming somatic cells: The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated... Agent: Whitehead Institute For Biomedical Research

20130109091 - Compositions and methods for modulation of smn2 splicing: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.... Agent: Isis Pharmaceuticals, Inc.

20130109092 - Method for obtaining pancreatic endocrine cells from adipose tissue-origin cells: A method of obtaining pancreatic endocrine cells from cells originating in an adipose tissue characterized by comprising culturing the adipose tissue-origin cells; the pancreatic endocrine cells that can be obtained thereby; a method of treating or preventing a disease caused by the hypofunction in pancreatic endocrine cells wherein the above-described... Agent: Osaka University

20130109093 - Method of producing tooth, set of teeth, and method of producing tissue: A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured... Agent: Organ Technologies Inc.

20130109094 - Dry powder cell culture products and methods of production thereof: The present invention relates to nutritive medium, medium supplement, media subgroup and buffer formulations. The present invention provides powder nutritive medium, medium supplement and medium subgroup formulations, e.g., cell culture medium supplements (including powdered sera such as powdered fetal bovine serum (FBS)), medium subgroup formulations and cell culture media comprising... Agent: Life Technologies Corporation

20130109095 - Method for transfecting a eukaryotic cell: The present invention relates to a method for transfecting a eukaryotic cell, wherein a compound comprising at least one saccharide and at least one protein and optionally a salt and/or a component stabilizing pH is brought into contact with a nucleic acid and a transfection reagent, a complex of nucleic... Agent: Qiagen Gmbh

20130109096 - Method for gene transfer: Disclosed is a method for introducing a gene into a target cell using a retrovirus vector, which is simple and highly efficient. Specifically disclosed is a method for introducing a gene into a target cell using a retrovirus vector, which comprises the steps of (a) placing a liquor containing a... Agent:

20130109098 - Biosecure genetically modified algae: Biosecure algae and methods for preparing biosecure algae that have a substantially decreased capability to survive in a natural environment are described. The methods include transforming a genetically modified alga to include an essential gene that is operably linked to a promoter system that is active only in the presence... Agent: Phycal, Inc

20130109097 - Compositions and methods for altering alpha- and beta-tocotrienol content using multiple transgenes: Preparation and use of isolated nucleic acids useful in altering the oil phenotype of plants are described. Isolated nucleic acids and their encoded polypeptides are described that alter the content of alpha-tocotrienol, beta-tocotrienol, or both, in transformed seeds and oil obtained from the transformed seeds. Expression cassettes, host cells and... Agent: E I Du Pont De Nemours And Company

20130101981 - Particle matrix for storage of biomolecules: Matrices for manipulation of biopolymers, including the separation, purification, immobilization and archival storage of biopolymers is disclosed.... Agent:

20130101982 - Fluid mixing systems with adjustable mixing element: A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive... Agent: Hyclone Laboratories, Inc.

20130101983 - Non contact real time micro polymerase chain reaction system and method thereof: The present disclosure provides a non contact real time micro Polymerase Chain Reaction [PCR] system comprises; a chip having a reaction chamber for holding a sample and an embedded metal heater below the reaction chamber for heating the sample; an optical unit comprising associated LED driver and photo detector amplifier... Agent: Bigtec Private Limited

20130101984 - Methods of detecting sleepiness: The present application is directed to methods of detecting sleepiness.... Agent: The Washington University

20130101988 - Compositions, methods and kits to detect herpes simplex virus nucleic acids: The disclosed invention is related to methods, compositions, kits and isolated nucleic acid sequences for targeting Herpes Simplex Virus (HSV) nucleic acid (eg. HSV-1 and/or HSV-2 nucleic acid). Compositions include amplification oligomers, detection probe oligomers and/or target capture oligomers. Kits and methods comprise at least one of these oligomers.... Agent: Gen-probe Incorporated

20130101987 - Detection of feline immunodeficiency virus: Method, device and kit for the detection of antibodies directed to Feline Immunodeficiency Virus (FIV). The method includes contacting the felid biological sample with FIV env polypeptide and detecting whether the polypeptide substantially binds to the antibody in the biological sample. The method will detect FIV antibodies in a sample... Agent:

20130101992 - Diagnostic assay for type 1 diabetes: There is an association between enteroviruses and type 1 diabetes (T1D). The present invention is based on the finding that particular enterovirus serotypes are T1D risk serotypes, while others are protective against the disease. The present invention relates to a diagnostic assay for type 1 diabetes (T1D), and especially to... Agent: Vactech Oy

20130101989 - Diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy: Described is a diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy, comprising exposing primary tumor cells from a patient, e.g., tumor cells obtained from a brain tumor or pancreatic cancer, to (i) a parvovirus and/or (ii) a chemotherapeutic agent or radiotherapy, and determining the reduction... Agent: Ruprecht-karis-universitaet Heidelberg

20130101986 - In vitro method for obtaining intrahepatic fibroblasts infected with hepatitis c virus: The present invention relates to in vitro methods for obtaining intrahepatic fibroblasts infected with hepatitis C virus, to the infected intrahepatic fibroblasts obtained by means of these methods, and also to methods for screening for anti-fibrogenesis molecules and for anti-HCV molecules using these cells.... Agent:

20130101985 - Methods for the detection of jc polyoma virus: Methods and compositions for determining whether a subject is at risk for PML, including subjects being treated with immunosuppressants, by determining whether the subject harbors a JCV variant with reduced binding for sialic acid relative to a normal JCV, are presented. Furthermore, combinations of JCV-VP1 sequence variations that are associated... Agent: Biogen Idec Ma Inc.

20130101993 - Microchemical chip, producing method thereof and method for using the microchemical chip: According to the microchemical chip of the present invention, the sample introducing port 11 is formed as a hole penetrating a face and a back of the first substrate 10, the sample flow path 21 is formed as a slit penetrating a face and a back of the second substrate... Agent: Metaboscreen Co., Ltd.

20130101991 - Microfluidic assay in idealized microvascular network for selection and optimization of drug delivery vehicles to simulated tumors: An apparatus for assaying a tumor drug delivery vehicle and or drug can include an idealized microvascular network (IMN) of one or more interconnected idealized flow channels in fluid communication through a porous wall with a tissue space (e.g., idealized tissue space) containing animal cells and means for quantifying drug... Agent: Cfd Research Corporation

20130101990 - Microfluidic system for amplifying and detecting polynucleotides in parallel: The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept... Agent: Handylab, Inc.

20130101996 - Detection method and apparatus of activated neutrophils: To provide a detection method of activated neutrophils enabling the classification of normal leukocytes and the detection of activated neutrophils, a measurement sample in which erythrocytes in a biotic sample are hemolyzed and nucleic acid of leukocytes is stained by a nucleic acid staining fluorochrome is prepared, the sample is... Agent: Sysmex Corporation

20130101995 - Device and method for pressure-driven plug transport: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.... Agent: The University Of Chicago

20130101994 - Method of analysing a cell or other biological material containing a nucleic acid: According to the invention there is provided a compound of Formula (I) in which: A is a C2-8 alkylene group; R1, R2, R3, and R4 are independently selected from hydrogen, C1-4 alkyl, C2-4 dihydroxyalkyl in which the carbon atom attached to the nitrogen atom does not carry a hydroxyl group... Agent: Biostatus Limited

20130102004 - Endometrial phase or endometrial cancer biomarkers: Methods for detecting endometrial diseases or an endometrium phase in a subject are described comprising measuring endometrial markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for endometrial diseases, and kits for carrying out the methods of the invention.... Agent:

20130101997 - Genetic marker for the diagnosis of dementia with lewy bodies: Specific alterations in BChE gene have been found which allow determining whether a patient suffers from dementia with Lewy bodies (DLB), and allow distinguishing it from Alzheimer's disease. The invention provides an in vitro method for the diagnosis of DLB comprising determining in a biological sample from a subject, the... Agent: Universitat Aut&#xd2 Noma De Barcelona

20130101998 - Method for diagnosing kidney disease comprising detecting the level of annexin a2 or s100a6: The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting,... Agent: National Defense Medical Center

20130102001 - Method to determine zygosity of the fad2 gene in canola using end-point taqman pcr: The subject disclosure relates in part to endpoint TaqMan® PCR assays for the detection and high throughput zygosity analysis of the fad-2 gene in canola. The subject disclosure further relates, in part, to the use of wild type DNA as a reference for use in determining zygosity. These and other... Agent: Dow Agrosciences LLC

20130102002 - Method to determine zygosity of the fad3 gene in canola using end-point taqman® pcr: The subject disclosure relates in part to endpoint TaqMan® PCR assays for the detection and high throughput zygosity analysis of the fad-3c gene in canola. The subject disclosure further relates, in part, to the use of wild type DNA as a reference for use in determining zygosity. These and other... Agent: Dow Agrosciences LLC

20130101999 - Multi-leg luminescent nanoparticles, multi-leg luminescent nanoparticle compounds and various applications: Multi-leg luminescent nanoparticles (“MLN's”) that can be paired to other MLN's as well s biological molecules to film branched multi-leg luminescent nanoparticles (“BMLN's) that can be used in biological multiplexing applications, imaging applications, biological detection applications and other biological applications.... Agent: Nanoaxis, LLC

20130102000 - Peptide nucleic acid probe, kit and method for detection and/or quantification of salmonella spp. and applications thereof: The present invention refers to the development of a Peptide Nucleic acid (PNA) probe for the detection of the Salmonella genus in different types of samples. PNA is a synthetic molecule analogue to DNA that, due to its physicochemical properties, allows a faster analysis with higher sensitivity than the DNA... Agent: Universidade Do Minho

20130102003 - Point-of-care immunoassay for quantitative small analyte detection: Point-of-care assays for quantitatively measuring the amount of small analytes, such as opioids, tetrahydrocannibinol (“THC”), or hormones, in a biological sample are disclosed. The assays are capable of non-competitive detection of a small analyte using binding agents that selectively bind the analyte and capture agents that selectively bind a complex... Agent: Decimadx, LLC

20130102006 - Detection method for novel ros1 fusions: Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising... Agent: Japanese Foundation For Cancer Research

20130102005 - Inhibitor leaching resistant nucleic acid storage reagent: The invention provides compositions and methods related to a nucleic acid storage reagent.... Agent: Imigene, Inc.

20130102007 - Compositions and methods for characterizing and regulating olfactory sensation: The present invention relates to the characterization of odorant receptors. In particular, the present invention relates to the OR7D4 proteins and nucleic acids encoding OR7D4 proteins and cell systems for screening for modulators of OR7D4 receptors. The present invention further provides assays for the detection of OR7D4 polymorphisms and mutations... Agent:

20130102008 - Method for screening for s1p lyase inhibitors using cultured cells: To provide a method for screening using cultured cells, intended to find a compound which increases the amount of sphingosine-1-phosphate or dihydrosphingosine-1-phosphate by SPL inhibitory activity rapidly, simply and highly sensitively. Provided are: a rapid and simple measurement method employing a scintillation proximity assay (SPA); a method with greatly improved... Agent: Daiichi Sankyo Company, Limited

20130102010 - T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds:

20130102011 - Human leucine-rich a-2-glycoprotein-1 and aminopeptidase n as risk indicators for cancer: Diagnostic tests for characterizing a test subject's risk of developing or having cancer, based on determining the level of LRG1 and/or CD13 in a bodily sample obtained from a test subject are described. Levels of LRG1 and/or CD13 are then compared to a predetermined value that is derived from measurements... Agent: Cleveland State University

20130102009 - Sirtuin activators and activation assays: Provided are methods and compositions for detecting a compound that activates a sirtuin deacetylase activity on a fluorescent-free activation substrate in vitro. Further provided are sirtuin modulating compounds of the formulas (I)-(XXI), and related compounds (XXXI), (XXXII), (XXXIII), and (XXXIV), including the fluorescent free-substrate SIRT1 activator compounds of formulas (XL),... Agent:

20130102012 - Fluorescent-labelled diubiquitin substrate for a deubiquitinase assay: The application relates to a substrate for measuring the activity of a deubiquitinating enzyme (DUB), comprising a diubiquitin molecule, wherein an ubiquitin monomer is labeled with a fluorescent label, as well as an assay for DUB enzymes using such substrates.... Agent: Medical Research Council

20130102014 - Fluorinated resorufin compounds and their application: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.... Agent: Life Technologies Corporation

20130102013 - Materials and methods to detect pyrimidine-pyrimidine dimer formation: Disclosed are methods and apparatuses pertaining to measuring DNA damage due to exposure to ultraviolet light, as measured by formation of pyrimidine-pyrimidine dimers in a polynucleotide. The apparatuses can be in the form of a patch which can be particularly useful in measuring the effectiveness of a sunscreen. The apparatuses... Agent: Empire Technology Development LLC

20130102015 - Composition for the determination of coagulation characteristics of a test liquid: The present invention is directed to a diagnostic composition for use in the viscoelastic analysis of a test liquid, and to a container (1) comprising same. The composition comprises at least an activator of coagulation, and at least one further constituent selected from CaCl2 and from one or more inhibitors... Agent: C A Casyso Ag

20130102016 - Glucose dehydrogenase: A modified pyrroloquinoline quinone glucose dehydrogenase that exhibits a high selectivity for glucose is provided. A modified pyrroloquinoline quinone glucose dehydrogenase is disclosed in which the amino acid residue G at Position 99 of a pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 1, or the amino acid... Agent: Arkray, Inc.

20130102017 - Fluorescent carbapenems: Chromogenic or fluorescent carbapenems according to formula I, wherein Ar is a mono or disubstituted carbocyclic aromatic group or an optionally mono or disubstituted heterocyclic aromatic group, are useful compounds for the detection of bacterial carbapenemase.... Agent:

20130102018 - Device and method for monitoring and quantifying analytes: The present invention can be described as an apparatus and cartridge for detecting the presence of an analyte in a fluid. The invention can also be described as a method of detecting the presence of an analyte in a fluid using the apparatus and cartridge. The method comprises the steps... Agent: The Research Foundation Of State University Of New York

20130102019 - Assessing the risk of a major adverse cardiac event in patients with chest pain: Methods for characterizing the near term risk of experiencing a major adverse cardiac event in a patient presenting with chest pain are provided. In one embodiment the method comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the patient. In another embodiment, the method comprises... Agent: The Cleveland Clinic Foundation

20130102020 - Detection and characterization of protein interactions, protein interaction modulation and protein interaction modulators: Protein interactions, protein interaction modulation, and protein interaction modulators can be detected and characterized through assessment of differential angular mobility and/or differential polarity exhibited by protein interaction reactants and products.... Agent:

20130102021 - Fluorogenic ph sensitive dyes and their method of use: o

20130102023 - Methods and compositions for growth of cells and embryonic tissue on a synthetic polymer matrix: The present invention provides methods and compositions for establishing and maintaining growth of cells and embryonic tissue on a synthetic polymer matrix. For example, the present invention provides synthetic growth matrices for stem cells, gametes, mature differentiated cells, and embryonic tissue (e.g., blastomeres, embryos, and embryoid bodies). In certain embodiments,... Agent: The Regents Of The University Of Michigan

20130102022 - Plants with altered cell wall biosynthesis and methods of use: Provided herein are plants having altered expression of a GAUT polypeptide. Such plants have phenotypes that may include decreased recalcitrance, increased growth, decreased lignin content, or a combination thereof. Also provided herein are methods of making and using such plants.... Agent: University Of Georgia Research Foundation, Inc.

20130102026 - Culture medium and a method for detection of parasites: This invention relates to a culture medium, a kit containing the culture medium and to a method for detection of a parasite such as Dientamoeba fragilis and/or another parasite. The culture medium of the invention is bi-phasic and includes a solid phase containing an egg slope or agar slope and... Agent:

20130102025 - Methods and compositions for identifying a cell phenotype: The present invention is directed to a method of identifying cancerous or precancerous cells suspended in a liquid carrier, such as, a biological fluid.... Agent: Zetiq Technologies Ltd.

20130102024 - Optical fluorescence dual sensors and methods of preparing and using them: The present invention relates to an optical fluorescence dual sensor comprising a probe for sensing pH, a probe for sensing oxygen, an intra-reference probe and a matrix. The present invention also relates to methods of preparing an optical fluorescence dual sensor and methods of using them.... Agent: Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of

20130102027 - Method for detecting cancer cells using vertically carbon nanotubes: The various embodiments herein provide a method for detecting the cancerous cells using the carbon nanotubes. The method comprises preparing a solution of the tissue cells. The prepared solution of the tissue cells is poured on a fabricated substrate to carry out an entrapment of the tissue cells on the... Agent:

20130102028 - Cartilage-specific hif-2alpha transgenic mouse as an animal model for arthritis, and use thereof: The present invention relates to a transgenic fertilized egg in which expression constructs, excluding human expression constructs, are introduced, including: (a) a nucleotide sequence encoding hypoxia-inducible factor 2α (HIF-2α); and (b) a transcription-regulating sequence which is operatively linked to the nucleotide sequence, as well as to a transgenic animal model... Agent: Gwangju Institute Of Science And Technology

20130102029 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy or sugary materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent: Xyleco, Inc.

20130102030 - Antibody molecules which bind il-17a and il-17f: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.... Agent: Ucb Pharma S.a.

20130102032 - Cell culture medium: A cell culture medium with high content of choline chloride is provided. The cell culture media further comprise only moderate amounts of amino acids, in particular the amount of glutamine in the cell culture media is limited. The cell culture media can be used for large scale production of polypeptides... Agent: Novartis Ag

20130102031 - Use of somatic hypermutation to create insertion and deletion mutations in vitro: The invention is directed to an in vitro method for introducing one or more insertion mutations and/or one or more deletion mutations in a nucleic acid sequence encoding a polypeptide. The method comprises contacting a cell in vitro with a nucleic acid sequence, and expressing Activation Induced Cytidine Deaminase (AID)... Agent: Anaptysbio, Inc.

20130102033 - Production method of extracellular polysaccharopeptides by trametes versicolor lh1 immobilization using liquid-surface complex carriers in submerged fermentation: The present invention relates to a culture method for enhancing the production of the extracellular polysaccharopeptides (EPS) by submerged fermentations with a mycelium immobilization by a local Trametes versicolor strain LH1 and significantly increasing the production of polysaccharopeptides with immunomodulatory activity of Trametes versicolor LH1 through mycelium immobilization by liquid-surface... Agent:

20130102034 - Modified nucleosides, nucleotides, and nucleic acids, and uses thereof: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using thereof.... Agent:

20130102035 - Variants of glucoamylase: The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DNA constructs... Agent: Dupont Nutrition Biosciences Aps

20130102036 - Novel marine bacterium of metabolizing 3,6-anhydro-l-galactose and use of the same: Disclosed is a novel marine microorganism which can metabolize 3,6-anhydro-L-galactose and use of the same. The novel marine microorganism belongs to Vibrio sp. which utilizes 3,6-anhydro-L-galactose (3,6-L-AHG) as a single carbon source to convert 3,6-L-AHG to ribose and 3,6-anhydrogalactonic acid.... Agent: Korea University Research And Business Foundation

20130102037 - Microorganism with enhanced l-lysine productivity and method for producing l-lysine using the same: Disclosed is an L-lysine-producing microorganism having gluconate kinase activity weakened in comparison to the endogenous activity thereof, and methods provided for preparing the microorganism and for producing L-lysine using the same.... Agent: Cj Cheiljedang Corporation

20130102038 - Method for producing patchoulol and 7-epi-alpha-selinene: A method of producing patchoulol and 7-epi-α-selinene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). The method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-α-selinene, compounds which can be useful in the field of perfumery.... Agent: Firmenich Sa

20130102041 - Enzymatic process for synthesizing estolides: This invention is a process for enzymatic synthesis of estolides through the reaction between stearic acid and methyl ricinoleate, using an immobilized lipase as the catalyst, in a solvent-free medium. This process prevents degradation of the product, reduces the formation of secondary products that generate color and odor in the... Agent: Petroleo Brasileiro S.a. - Petrobras

20130102042 - Genetically modified fungi and their use in lipid production: The invention refers to fungal cells, and especially to oleaginous fungal cells that have been genetically modified to produce enzymes of the pyruvate dehydrogenase bypass route to enhance their lipid production. Especially the cells are modified to over-express genes encoding pyruvate decarboxylase (PDC), acetaldehyde dehydrogenase (ALD) and/or acetyl-CoA synthetase (ACS),... Agent: Teknologian Tutkimuskeskus Vtt

20130102039 - Methods of producing triacylglyceride compositions comprising tailored oils: Methods and compositions for the production of food compositions, oils, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase,... Agent: Solazyme, Inc.

20130102040 - Use of endogenous promoters in genetic engineering of nannochloropsis gaditana: The present disclosure is directed to novel polynucleotide sequences for use in Nannochloropsis gaditana. The novel polynucleotide sequences include control sequences and coding sequences. Also disclosed are novel gene expression constructs wherein N. gaditana promoters/control regions are operatively linked to N. gaditana or non-N. gaditana coding sequences. These novel polynucleotide... Agent: Colorado School Of Mines

20130102043 - Efficient process for producing alcohol: A process for producing ethanol including a combination of biochemical and synthetic conversions results in high yield ethanol production with concurrent production of high value coproducts. An acetic acid intermediate is produced from carbohydrates, such as corn, using enzymatic milling and fermentation steps, followed by conversion of the acetic acid... Agent: Zeachem, Inc.

20130102044 - Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation: Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme... Agent:

20130102045 - Grain milling process: A modification is described of a dry grind process for producing ethanol and other co-products from whole grain, whereby the mash is thermochemically treated by cooking the mash in the presence of an organic acid. The organic acid effectively hydrolyzes both the starch and hemicellulosic components in the milled corn... Agent: Archer Daniels Midland Company

20130102046 - Xylose-fermenting microorganism: The present disclosure provides compositions and methods related to the fermentation of xylose. Host cells having recombinant polynucleotides encoding one or more of aldose reductases, xylitol dehydrogenases, and xylulokinase are provided herein. Host cells having reduced expression of PHO13 are also provided herein. Also provided herein are uses of host... Agent: The Board Of Trustees Of The University Of Illinois

20130102047 - Oil-based material-producing method and oil-based material-producing apparatus: An oil-based material-producing method includes a microwave irradiation step of irradiating oil-based material-producing microorganisms with microwaves. The oil-based material-producing method may also include a collecting step of collecting an oil-based material produced by the oil-based material-producing microorganisms after the microwave irradiation step.... Agent: Microwave Chemical Co., Ltd.

20130102048 - Method of retrovirus storage: A method of retrovirus storage, characterized in that a retrovirus is sustained in the presence of a substance with retrovirus binding activity immobilized on a solid phase. Further, there is provided a retrovirus composition characterized in that a retrovirus in the form of binding to a substance with retrovirus binding... Agent: Takara Bio Inc.

20130102049 - Removable saccharide-benzimidazole (bim) tags and conjugates thereof via 1h-position of the benzimidazoles: Novel method and reagents for generating reversibly tagged saccharides, aldehydes, carboxyl acids, or orthoacetates useful in analytical and diagnostic applications are disclosed. Saccharides are coupled at the reducing end to tagging moieties comprising a reagent selected from a ortho-diaminobenzoic(DAB)-peptide, an aldo-imidazole or N-methylated aldo-imidazole, or an ortho-phenyldiamine (OPD) or substituted... Agent: Academia Sinica

20130102050 - Enzymatic nucleic acid synthesis: compositions and methods for inhibiting pyrophosphorolysis: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents... Agent: Life Technologies Corporation

20130102051 - Cellulose hydrolase and gene thereof: A cellulose hydrolase and a gene thereof are obtained by screening a cDNA genomic library constructed with Orpinomyces sp. Y102. The gene is 1071 base pairs long and comprises an open reading frame (ORF) for producing the cellulose hydrolase comprising 357 amino acids by translation. A transformed cell and a... Agent: Institute Of Nuclear Energy Research, Atomic Energy Council, Executive Yuan

20130102052 - Modified secretion system to increase expression of polypeptides in bacteria: The present invention provides methods of altering the production of desired polypeptides in a host cell. In particular, the present invention provides polynucleotides encoding truncated SecG proteins capable of facilitating the secretion of desired proteases by a bacterial host cell, such as Bacillus species, as well as expression vectors and... Agent: Danisco US Inc.

20130102053 - Multi plasmid system for the production of influenza virus: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken... Agent: Medimmune, LLC

20130102054 - Systems and methods for interior energy-activation from an exterior source: A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce... Agent: Immunolight, LLC

20130102055 - Continuous flocculation deflocculation process for efficient harvesting of microalgae from aqueous solutions: A continuous process for efficiently harvesting microalgae from aqueous systems is described herein. The method and apparatus of the present invention allows continuous harvesting of algae from a variety of source waters including saltwater, brackish water, fresh water, and treated wastewater. High concentration factors are achievable and the system produces... Agent: Board Of Regents, The University Of Texas System

20130102056 - Liquid curtain photobioreactors: A relatively low cost, highly productive, scalable culture vessel, and method to grow photosynthetic organisms, in particular autotrophic algae, is provided. The culture vessel can be constructed of a transparent plastic enclosure. One or more thin sheets, films, droplets, or streams of a free falling suspension of organism in liquid... Agent: Exxonmobil Research And Engineering Company

20130102057 - Vmp-like sequences of pathogenic borrelia species and strains: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis.... Agent: Board Of Regents, The University Of Texas System

20130102058 - Dehairing of skins and hides: The present invention relates to a method for the processing of hides or skins into leather, comprising enzymatic treatment of the hide or skin with carbohydrase in the soaking step. The present invention can achieve optimal fiber opening results in a relatively short period of time and at the same... Agent: Novozymes A/s

20130102059 - Methods and apparatus for organ support: An organ support apparatus includes: (a) a fluid circuit defining upstream and downstream legs adapted to be connected to an organ to be supported; (b) a circulation pump connected to the fluid circuit for circulating a process fluid through the fluid circuit and the organ; and (c) a first waveform... Agent:

20130102060 - Lance device and associated methods for delivering a biological material into a biological structure: Systems, devices, and methods for delivering a biological material into a biological structure are provided. In one aspect, for example, a lance device for introducing biological material into a biological structure and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a... Agent: Nanoinjection Technologies, L.L.C.

20130102061 - Systems and methods for auto-calibration of resistive temperature sensors: The invention relates to systems and methods for calibrating and using resistance temperature detectors. In one embodiment, the system includes a calibration circuit comprising a resistance temperature detector in a bridge circuit with at least one potentiometer, and a programmable gain amplifier coupled to the bridge circuit. Embodiments of the... Agent: Canon U.s. Life Sciences, Inc.

20130102062 - Microchip for nucleic acid amplification reaction and method of producing the same: Provided is a microchip for a nucleic acid amplification reaction, including a well configured to function as a reaction site of the nucleic acid amplification reaction, and the well has a center portion and a marginal portion, a substance anchored in a form that the substance is eccentrically-located less at... Agent: Sony Corporation

20130102064 - Rt-pcr chip with optical detection: An apparatus (100) for performing thermal cycles has a frame (131-134, 137, 147) enclosing a thermal chamber (110) laterally delimited by delimitation walls (103, 154a, 154b) and configured so as to be delimited at the bottom by a reaction holder (104) carrying a plurality of reaction chambers (107) designed to... Agent: Stmicroelectronics S.r.l.

20130102063 - Small molecules and protein analysis devices based on molecular imprinted polymers: Devices, methods and kits for rapid and simple determination of target molecules, including small molecules, polypeptides, proteins, cells and infectious disease agents in liquid samples that are capable of real-time measurement of these entities in fluid samples that are highly selective, highly sensitive, simple to operate, low cost, and portable.... Agent:

20130102067 - Cell monitoring by means of scattered light measurement: A device for monitoring test cells has at least one receiving unit for the test cells and a first measuring unit for cell measurement. With a second measuring unit, which has a light source and a scattered light detector, cell monitoring can be carried out during the cell measurement. For... Agent:

20130102066 - Chalcogenide-fibre, infrared evanescent wave sensor and process for producing same: The invention relates to a fibre sensor that enables the propagation of infrared light at at least one wavelength of 0.8 to 25 micrometres, the fibre successively comprising along its length a first infrared waveguide section (23), a second detection section (25) intended to come into contact with an external... Agent: Universite De Rennes 1

20130102065 - Small volume and fast acting optical analyte sensor: A fast acting sensor designed to accommodate an aqueous analyte-containing sample having a volume of less than one microliter and that can be used to quantify the amount and concentration of such analyte in the sample through light reflectance or fiber-optic light reflectance. The sensor includes a storage chamber, a... Agent:

20130102068 - Culture apparatus and method of replacing culture medium: There is provided a culture apparatus including: a first pipe having a discharge channel formed at one end thereof; a second pipe having a suction channel formed at one end thereof; and a connection channel connecting the first and second pipes.... Agent: Samsung Electro-mechanics Co., Ltd.

20130102069 - Algae reactor: The invention relates to a method for transferring light generated by a light emitting diode towards an aqueous liquid containing algae. The method includes emitting light by the light emitting diode having a first refractive index, transferring the light through a liquid medium having a second refractive index, and a... Agent: Tendris Solutions B.v.

20130102070 - Cell expansion system and methods of use: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits... Agent: Terumo Bct, Inc.

20130102071 - System and method for preparing cell culture dish media: Systems for preparing cell culture dish media are provided which are well adapted for preparing cell culture media, supplements, additives and/or other ingredients in an efficient and versatile manner to form sterilized cell culture dish media having a variety of ingredients well adapted with respect to uniformity and nutritional content... Agent: Toku-e Company

20130102072 - Suppression of b-cell apoptosis in transgenic animals expressing humanized immunoglobulin: The invention provides a novel approach to increase immunoglobulin expression in non-human transgenic animals. For instance, the invention provides a method to increase humanized immunoglobulin production in animals genetically engineered to express one or several human or humanized immunoglobulin transloci. This can be done by overexpressing the apoptosis inhibitor, i.e.... Agent: Therapeutic Human Polyclonals, Inc.

20130102073 - Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells: Activated human embryos produced by therapeutic cloning can give rise to human totipotent and pluripotent stem cells from which autologous cells for transplantation therapy are derived. The present invention provides methods for producing activated human embryos that can be used to generate totipotent and pluripotent stem cells from which autologous... Agent: Advanced Cell Technology, Inc.

20130102074 - Methods for reprogramming somatic cells: The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated... Agent: Whitehead Institute For Biomedical Research

20130102075 - Methods of cell culture for adoptive cell therapy: An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up... Agent:

20130102076 - Systems and methods for growing photosynthetic organisms: Methods and apparatus for promoting the growth of an aquatic photosynthetic organism within a growth medium in a photobioreactor may use a luminescent material targeting the aquatic photosynthetic organism in the photobioreactor. The luminescent material may be a substrate with a matrix of conductors coupled to the substrate, and light... Agent:

20130102077 - Alterations utilizing nanoparticles: Alterations utilizing nanoparticles. Certain embodiments of the invention are methods of delivering a substance to a target using a delivery-aid which includes nanoparticles. Those nanoparticles may be nanocarbon particles. Other embodiments are methods of delivering nanoparticles to a target involving placing a mask between a source of ballistic delivery of... Agent: International Technology Center

20130102078 - Nanoinjection system dna placement pipette coupler: Systems, devices, and methods for injecting biological material into a micro-object such as a cell are provided. In one aspect, for example, a cellular injection device can include a housing, an injection lance coupled to the housing and having a working tip extending outward from the housing, and a biological... Agent: Nanoinjection Technologies, L.L.C.

20130102079 - Polyamine-containing polymers and methods of synthesis and use: The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).... Agent: Alberta Innovates - Technology Futures

20130102080 - Methods for reprogramming somatic cells: The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated... Agent: Whitehead Institute For Biomedical Research