SEARCH:      Monitor Keywords |  Custom RSS

Chemistry: molecular biology and microbiology March listing by industry category 03/13

20130078608 - Zeodration method for the preservation of blood platelets: The present invention relates to a new method for the preservation of blood platelets. In particular, the present invention provides a method which includes submitting the platelets to zeodration carried out at temperatures between 18° C. and 24° C. The dried platelets thus obtained can be preserved at room temperature... Agent: Establissement Francais Du Sang

20130078610 - Method and system for thermal cycling of microfluidic samples: A thermal cycler for a microfluidic device includes a controller operable to provide a series of electrical signals, a heat sink, and a heating element in thermal communication with the heat sink and operable to receive the series of electrical signals from the controller. The thermal cycler also includes a... Agent: Fluidigm Corporation

20130078609 - Thermal cycling: A processing apparatus includes a carrier receiving region configured to receive a sample carrier with at least one channel that carries at least one sample. The apparatus further includes a thermal control device configured to thermal cycle the sample carrier when the sample carrier is installed in the carrier receiving... Agent: Analogic Corporation

20130078618 - Compositions, reaction mixtures and methods for detecting nucleic acids from type a1 and/or type c1 human papillomavirus: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products... Agent: Gen-probe Incorporated

20130078620 - Device and method for detection and identification of immunological proteins, pathogenic and microbial agents and cells: The present invention provides a method and device for detecting and quantifying the concentration of magnetic-responsive micro-beads dispersed in a liquid sample. Also provided is a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a sample medium by using antigen-specific antibody-coated magnetic-responsive... Agent:

20130078615 - Device and method for detection and quantification of immunological proteins, pathogenic and microbial agents and cells: The present invention provides a method and device for detecting and quantifying the concentration of magnetic-responsive micro-beads dispersed in a liquid sample. Also provided is a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a sample medium by using antigen-specific antibody-coated magnetic-responsive... Agent:

20130078616 - Method and system for amplification of nucleic acids in microfluidic volume hydrogels: The present invention provides for a novel method and system for amplification of nucleic acids within a hydrogel of microfluidic volume using a hydrocarbon wax as a support substrate.... Agent: The Governors Of The University Of Alberta

20130078611 - Method for detecting microorganisms and a kit thereof: The present invention provides a method for detecting microorganisms comprising steps of PCR, magbead, complex forming, blocking and washing and reporting, in which microorganisms, particular to HBV, can be easily detected via a time-saving and user-friendly process, with high sensitivity and stability. Furthermore, according to the method for detecting microorganisms,... Agent:

20130078612 - Method for detecting microorganisms and a kit thereof: The present invention provides a method for detecting microorganisms comprising steps of PCR, magbead, complex forming, blocking and washing and reporting, in which microorganisms, particular to HBV, can be easily detected via a time-saving and user-friendly process, with high sensitivity and stability. Furthermore, according to the method for detecting microorganisms,... Agent: Asiagen Corporation

20130078614 - Probe for hpv genotype diagnosis and analysis method thereof: The present invention relates to a probe for diagnosing HPV genotype and to a method of analyzing the same.... Agent: M & D, Inc.

20130078617 - Sample analyzer and method for controlling sample analyzer: A sample analyzer transports a first rack and a second rack, the first rack including a first number of supporters for supporting containers that contain biological samples of subjects, and the second rack including a second number of supporters for supporting containers that contain standard samples. The sample analyzer determines... Agent: Sysmex Corporation

20130078619 - Sample preparation device: A sample preparation device is disclosed. The sample preparation device includes a housing defining a passage way between a first opening and a second opening; and a sample filter occupying a section of said passage way. The sample filter contains a monolith adsorbent that specifically binds to nucleic acids. Also... Agent: Akonni Biosystems, Inc.

20130078613 - Selection of hcv treatment: The present invention is based on the discovery of an association between the SNP genotype at the rs12979860 locus in the IL28B gene promoter and the probability of achieving a SVR in HC V-infected patients that are given a triple therapy treatment that contains peginterferon alfa-2a, ribavirin, and a HCV... Agent: Roche Molecular Systems

20130078623 - Biological analysis arrangement and approach therefor: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20130078621 - Detection composition: The invention provides methods, kits, devices and compositions for detecting one or more target analytes. In some embodiments, the invention provides binding elements and labeling elements capable of being joined through a plurality of joining elements.... Agent: Nodality, Inc.

20130078622 - Electronic device for monitoring single molecule dynamics: A single molecule sensing device includes a first electrode, a second electrode and a single-walled carbon nanotube (SWNT) connected to the first and second electrodes. At least one linker molecule having first and second functional groups is functionalized with a sidewall of the SWNT, the at least one linker molecule... Agent: The Regents Of The University Of California

20130078637 - Antipsychotic-induced parkinsonism genotypes and methods of using same: The present invention relates to genotypes associated with resistance to antipsychotic-induced parkinsonism and other extrapyramidal symptoms induced by antipsychotics, and use of said genotypes for assessment of patient populations. The methods and kits of the invention are based on identifying in a sample obtained from a subject, specific SNPs in... Agent: Hadasit Medical Research Services And Development Ltd.

20130078626 - Categorization of dna samples: The present application describes methods for accurate and cost-effective categorization of DNA samples into different types of in vitro generated DNA or different types of natural DNA such as from different tissues and/or physiological/pathological states. The invention achieves categorization by comparing “signal ratios” that are correlated to ratios of methylation... Agent: Nucleix

20130078633 - Detection of isotype profiles as signatures for disease: The invention provides a non-invasive technique for the detection and quantification of immunoglobulin isotypes, in a biological sample containing a plurality of distinct cell populations. Methods are conducted using sequencing technology to detect and enumerate immunoglobulin isotype profiles within a heterogeneous biological sample.... Agent: Immumetrix, LLC

20130078625 - Fluid handling apparatus and configurations: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that... Agent: Theranos, Inc., A Delaware Corporation

20130078627 - Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, variant proteins... Agent: Celera Corporation

20130078632 - Materials and methods for prognosis of progression of barrett's esophagus: A method of prognosticating progression of Barrett's esophagus in a patient comprising detecting in a sample of esophageal cells from the patient at least one abnormality selected from the group consisting of p16 loss, p53 loss, chromosome 7 aneuploidy, and chromosome 17 aneuploidy, which method can further comprise detecting at... Agent: Academisch Medisch Centrum

20130078636 - Method for detecting and quantitating multiple subcellular components: A method for detecting and quantitating multiple and unique fluorescent signals from a cell sample is provided. The method combines immunohistochemistry and a fluorescent-labeled in situ hybridization techniques. The method is useful for identifying specific subcellular components of cells such as chromosomes and proteins.... Agent: Ikonisys, Inc.

20130078629 - Method for detecting nucleic acids by promoting branched dna complex formation: Disclosed is a method for detecting nucleic acids by promoting branched DNA complex formation. The target nucleic acid detection signal and sensitivity can be dramatically increased by promoting self assembly of branched DNA between a plurality of amplified DNA targets and a single-chain oligonucleotide probe, by means of the integrated... Agent:

20130078631 - Probe, and polymorphism detection method using the same: The present disclosure relates to a probe for detecting a polymorphism, a method of detecting a polymorphism, a method of evaluating the efficacy of a drug, and a reagent kit for detecting a polymorphism.... Agent: Arkray, Inc.

20130078635 - Rapid method for identifying drug-resistant gene using artificial chromosome of plasmodium, and method for preparing recombinant plasmodium: The present invention relates to a rapid method for identifying a drug-resistant gene using an artificial chromosome of a protozoa. Specifically, it relates to a method for screening for a drug-resistant gene, which involves preparing a recombinant Plasmodium using an artificial chromosome of a Plasmodium, either inoculating the recombinant Plasmodium... Agent: Mie University

20130078634 - Sequences and their use for detection and characterization of stec bacteria: This invention relates to a rapid method for detection and characterization of STEC bacteria based on the presence of nucleic acid sequences, in particular, to a PCR-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. This method is preferably employed to detect STEC bacteria in... Agent:

20130078628 - Single nucleotide polymorphisms of human chromosome 4 in the inositol polyphosphate-4-phosphatase type ii gene (inpp4b gene) for the diagnosis or pre-diagnosis of multiple sclerosis: The invention relates to a single nucleotide polymorphism (SNP) of the nucleobase at base position 143470133 (rs13102150) of human chromosome 4 in the inositol polyphosphate 4-phosphatase type II gene (INPP4b gene) for the diagnosis or pre-diagnosis of multiple sclerosis or for determining the risk of contracting multiple sclerosis.... Agent:

20130078624 - Systems and methods for multi-purpose analysis: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that... Agent: Theranos, Inc., A Delaware Corporation

20130078630 - Use of g-clamp for improved allele-specificpcr: The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having at least one selective nucleotide complementary to only one variant of the target sequence and incorporating at least one “G-clamp” nucleotide.... Agent: Roche Molecular Systems, Inc.

20130078638 - Bead emulsion nucleic acid amplification: Disclosed are methods for nucleic acid amplification wherein nucleic acid templates, beads, and amplification reaction solution are emulsified and the nucleic acid templates are amplified to provide clonal copies of the nucleic acid templates attached to the heads. Also disclosed are kits and apparatuses for performing the methods of the... Agent:

20130078642 - Biomarkers for lung neuroendocrine tumors: The present invention regards a method for providing a diagnosis for small cell lung carcinoma and for typical carcinoid tumor by using a panel of protein biomarkers which are differentially expressed and a method for screening compounds.... Agent: Porto Conte Richerche S.r.l.

20130078640 - Processes for detection of nucleic acids: This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the... Agent: Enzo Life Sciences, Inc.

20130078641 - Sample processing method and device: The present invention provides a method and device for treating and analyzing a biological specimen. The biological specimen is introduced into a processing device and treated thermally, mechanically, chemically or any combination thereof within the processing device to alter at least one constitutive characteristic of the biological specimen and to... Agent: Streck, Inc.

20130078639 - System and method of detecting and correcting for nucleic acid damage: The present disclosure describes a method to estimate a geometric parameter to describe the degradation pattern (i.e. the proportion of bases that are damaged) in a sample. Using the values provided by the described systems and methods, researchers can estimate the proportion of undamaged fragments that are a certain base... Agent: International Genomics Consortium

20130078643 - Device and method of detecting tsh: A device for detecting the concentration of biological materials, is formed in a body having a plurality of fluidic paths connectable to a multi-microbalance structure carrying a plurality of microbalances, each microbalance having a sensitive portion facing a reaction chamber. The body and the multi-microbalance structure are configured to be... Agent: Stmicroelectronics S.r.l.

20130078644 - Post-translational modifications identified by elemental analysis: Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate analysis of post-translation modifications of substrates by enzymes involved in post-translational modifications, including kinase and phosphatase enyzmes... Agent: Dvs Sciences, Inc.

20130078646 - Antibodies, compositions, and assays for detection of cardiac disease: The present invention provides antibodies, devices, and immunoassays for detection of ischemic cardiac events (unstable angina and heart attack) in patients experiencing chest pain. The invention allows for rapid determination of the cause of chest pain, and allows for differentiation of chest pain due to ischemic cardiac events and other... Agent: Nour Heart, Inc.

20130078649 - Combination therapy for the treatment of obesity and diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level: The present invention concerns combination of an amount of a BRS-3 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the... Agent: Arena Pharmaceuticals, Inc.

20130078648 - Direct examination of biological material ex vivo: The present invention relates to a method for the visual examination of biological material ex vivo and an apparatus for the sterical orientation of biological material which can be used in said method.... Agent: Eberhard-karls-universitaet Tuebingen Universitaetsklinikum

20130078647 - Methods of detection of changes in cells: Methods are provided to detect changes in cells without the use of detection labels.... Agent: X-body, Inc.

20130078650 - Identifying material from a breast duct: Methods and systems for identifying material from a breast duct using one or more markers that can be identified in ductal fluid retrieved from the breast are provided.... Agent: Atossa Genetics, Inc.

20130078645 - Biomarkers: The invention relates to a method of diagnosing or monitoring schizophrenia or other psychotic disorder. The biomarkers used are selected from cyclophilin A, cytosalic non-specific dipepditase, Caoctosin-like protein, Glucose-6-phosphate isomerase, uncharacterized protein KIAA0423, myosin 14, myosin 15, nicotinamide phosphoribosyltransferase, pyruvate kinase isozyme R/L, phosphoglyterate mutase 4.... Agent: Psynova Neurotech Ltd.

20130078653 - Antibodies, compositions, and assays for detection of cardiac disease: The present invention provides antibodies, devices, and immunoassays for detection of ischemic cardiac events (unstable angina and heart attack) in patients experiencing chest pain. The invention allows for rapid determination of the cause of chest pain, and allows for differentiation of chest pain due to ischemic cardiac events and other... Agent:

20130078651 - Individual information determining method, individual information determining device, electronic apparatus, and individual information determining program: Disclosed in an individual information determining method in which individual information of a subject is determined based on one or a plurality of pieces of biomolecule data collected from a surface of a body surface of the subject.... Agent: Sony Corporation

20130078652 - Methods and kits for determining von willebrand factor activity in the absence of ristocetin and for determining the activity of adamts-13 protease: Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.... Agent:

20130078654 - Methods for diagnosing rheumatoid arthritis: The present invention relates to methods of diagnosing, prognosing, preventing or delaying onset of or treating rheumatoid arthritis, methods of distinguishing between different types or stages of rheumatoid arthritis, of identifying an individual at risk of developing rheumatoid arthritis, and of monitoring efficacy of a treatment regime in an individual... Agent: Imperial Innovations Limited

20130078656 - Artificial immune system: methods of use: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates... Agent: The Scripps Research Institute

20130078657 - Hyperthermia augmented in-vitro immune recognition: The present invention relates to a method for generation of a test-antigen specific cell-mediated immune response by incubating at hyperthermic conditions and, more particularly, a method for generation of a test-antigen specific cell-mediated immune response by incubating at hyperthermic conditions and optionally adding IL-7 and/or blocking IL-10. Even more particularly,... Agent: Hvidovre Hospital

20130078655 - Kidney prognostic assay: The invention provides a method of predicting subjects at risk of loss of kidney function and/or identifying subjects at greater risk of loss of kidney function, and/or identifying subjects at risk of kidney failure/end stage kidney disease, the method comprising detecting an amount of free light chains (FLC) in a... Agent: The Binding Site Group Limited

20130078658 - Method of quantifying recovery rate of exosome: A recombinant exosome comprising a fusion protein of a membrane protein and light-emitting protein, and a method of determining an exosome recovery rate by using the recombinant exosome are provided. Use of the method ensures accurate quantification of exosomes in a sample, and thus, improves the efficiency of an exosome-based... Agent: Samsung Electronics Co., Ltd.

20130078659 - Method for quantitatively determining ldl cholesterols: A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholestrols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the... Agent:

20130078660 - Methods and compositions for detecting protein modifications: Methods and compositions for detecting a protein modification in vitro and in vivo are disclosed. In certain embodiments, the protein modification detected is phosphorylation.... Agent: Salk Institute For Biological Studies

20130078661 - Compounds and methods for fret based measurement of enzyme activity: Provided are compositions and methods for Fluorescence/Forster Resonance Energy Transfer (FRET) analysis of cleavage of Von Willebrand Factor (VWF) polypeptides by the metalloprotease ADAMTS13. The polypeptides contain: i) a first fluorescent protein ii) a VWF amino acid sequence and iii) a second fluorescent protein. The VWF amino acid can contain... Agent: The Research Foundation For The State University Of New York

20130078662 - Bacillus pumilus bilirubin oxidase and applications thereof: The present invention relates to a novel Bacillus pumilus bilirubin oxidase, to the method for preparing same and also to the use thereof in particular for assaying bilirubin and for using enzymatic biofuel cells.... Agent:

20130078664 - Methods for assaying percentage of glycated hemoglobin: The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular... Agent: General Atomics

20130078663 - Pore-limit electrophoresis (ple) microchannel assays: Pore-limit electrophoresis (PLE) microchannel assay methods are provided. Aspects of the methods include sequentially introducing samples at least suspected of containing first and second assay members into a PLE microchannel and then evaluating the microchannel for interaction between the first and second assay members. Aspects of the invention further include... Agent:

20130078666 - Scaffold-based organotypic culture for the long-term cultivation of human epidermal stem cells: The present invention relates to organotypic cultures of epidermal cells and the use thereof for the screening of pharmaceutical and cosmetic agents. Specifically, means for the improvement of the long-term stability of such cultures are disclosed. Thus, the present invention contemplates a skin equivalent comprising (a) a dermal equivalent comprising... Agent: Deutsches Krebsforschungszentrum

20130078665 - Test strip, a test kit and a method for detection of endotoxin in food: A home test strip for detection of endotoxin in food, the test strip includes an amebocyte lysate component, a chromogenic substrate component, and a carrier matrix. The amebocyte lysate component and the chromogenic substrate component are located in close proximity to each other and further incorporated within the carrier matrix.... Agent:

20130078668 - Method and apparatus for detecting the presence of intraerythrocytic parasites: An apparatus and method for determining the presence of an intraerythrocytic organism within a sample of liquid whole blood is provided. The method includes the steps of a) creating an image of the sample quiescently residing within a sample chamber; b) evaluating the image for the presence of at least... Agent: Abbott Point Of Care, Inc.

20130078669 - Method and devices for the cross-referencing of identification of tissue slice supports for microtomised analytical samples: The invention relates to a method and device for the cross-referencing of identification (1) of tissue slice supports (2), for microtomised analytical samples still to be mounted thereon, with identification information (3) of a tissue sample holder (4) of a tissue sample (5) which is not yet microtomised. The conventional... Agent: Microm International Gmbh

20130078667 - Methods for detecting and collecting circulating tumor cells: The present invention is directed towards methods of expanding circulating tumor cell populations and methods of detecting circulating tumor cells in a sample.... Agent:

20130078670 - Microtome sectionable biopsy support for orienting tissue samples: Tissue orientation devices include a perforated tissue support with at least one perforated channel for receiving a tissue sample, and a plurality of tabs configured to extend along and into the channel to retain the tissue sample during processing and embedding. Tissue orientation devices include elongated legs coupled together for... Agent: Biopath Automation, L.L.C.

20130078671 - Incorporation of two different noncanonical amino acids into a single protein: The invention relates to methods, systems, and compositions for the genetic incorporation of a plurality of different noncanonical amino acids into one target protein. The invention provides for multiple, mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs that suppress two different selector codons engineered into a polynucleotide molecule. By virtue of the suppression... Agent: The Texas A&m University System

20130078674 - Method for protein production in filamentous fungi: The present invention relates to a method for genetically modifying a filamentous fungus host for improved protein production. The method comprises that a filamentous fungus host is genetically modified to overexpress or to be deficient of specific genes. The invention relates also to the modified hosts. Furthermore, the invention relates... Agent: Teknologian Tutkimuskeskus Vtt

20130078672 - Polypeptides having xylanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20130078673 - Recombinant microorganism having an ability of using sucrose as a carbon source: The present invention relates to a recombinant microorganism capable of metabolizing sucrose, and more particularly to a recombinant microorganism capable of metabolizing sucrose in which a gene encoding sucrose phosphotransferase and/or a gene encoding sucrose-6-phosphate hydrolase is introduced or to a recombinant microorganism capable of metabolizing sucrose in which a... Agent: Korea Advanced Institute Of Science And Technology

20130078675 - High affinity human antibodies to human il-4 receptor: The present invention provides nucleic acid molecules that encode antibodies or antigen-binding fragments thereof, which specifically bind human interleukin-4 receptor (IL-4R). Also provided are expression vectors comprising nucleic acid molecule that encode anti-IL-4R antibodies, host cells comprising the expression vectors, and methods of producing anti-IL-4R antibodies or antigen-binding fragments thereof... Agent: Regeneron Pharmaceuticals, Inc.

20130078676 - Method of regulating oligonucleotide functionality: The present invention relates generally to a method of regulating oligonucleotide functionality and, more particularly, to a method of regulating the functionality of a primer or probe. The method of the invention is designed to provide a means to selectively inactivate or activate the functionality of an oligonucleotide, such as... Agent: Monoquant Pty Ltd

20130078680 - Method for production of fermentable sugars from biomass: A process for production of fermentable sugars from biomass using multi-enzyme multi-step system is provided herein. The process disclosed in the present invention provides high yielded sugars in less time period. The multi-enzyme system disclosed in the present invention converts celluloses, hemicelluloses and/or mixture thereof to fermentable sugar with higher... Agent: Chemical Engineering Department, Institute Of Chemical Technology (deemed University)

20130078679 - Polypeptides having cellobiohydrolase 1 activity and polynucleotides encoding same: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.... Agent: Novozymes A/s

20130078677 - Process for the production of carbohydrate cleavage products from a lignocellulosic material: A process for the production of carbohydrate cleavage products, characterized by a combination of the measures that a lignocellulosic material is treated with an aqueous solution containing an alcohol, in particular a C1-4-alcohol or a phenol, and having a pH-value of between 11.0 and 14.0 in order to cleave lignocellulose... Agent: Annikki Gmbh

20130078678 - Protozoan glycosidases and related methods: Nucleic acids encoding glycosidases useful for the hydrolysis of cellulose and hemicellulose obtained from ciliates residing in a bovine rumen are provided. Also provided recombinant nucleic acids encoding the glycosidases, transformed cells comprising the same and related methods of using the transformed cells and glycosidases to degrade cellulose and/or hemicellulose.... Agent: The Curators Of The University Of Missouri

20130078681 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family having attenuated expression of genes encoding a lysine/arginine/ ornithine transporter: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, in which expression of a gene encoding a lysine/arginine/ornithine transporter has been attenuated.... Agent: Ajinomoto Co., Inc.

20130078682 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family, having attenuated expression of gene(s) encoding peptidase: The present invention provides a method for producing L-amino acids, such as L-arginine, L-citrulline, and L-lysine, using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more genes, such as the pepA, pepB,... Agent: Ajinomoto Co., Inc.

20130078683 - Host cells and methods for producing cinnamoyl anthranilate and analogs thereof: The present invention provides for a method of producing a cinnamoyl anthranilate, or analog thereof, in a genetically modified host cell.... Agent: The Regents Of The University Of California

20130078684 - Acyl-acp wax ester synthases: The invention relates to acyl-CoA-independent methods of producing a wax ester in recombinant host cells engineered to express an acyl-ACP wax ester synthase, and an alcohol-forming acyl-ACP reductase. The methods of the invention may take place in photosynthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing an... Agent: Exxonmobil Research And Engineering Company

20130078685 - Ozonolysis of unsaturated fatty acids and derivatives thereof: The invention relates to a method for the ozonolysis of unsaturated fatty acids and derivatives thereof, comprising a) ozonolysis of a fatty acid or of a derivative thereof in an organic phase comprising an organic solvent, and b) contacting the organic phase with an aqueous phase comprising catalase and preferably... Agent: Evonik Degussa Gmbh

20130078686 - Production and secretion of fatty acids and fatty acid derivatives: The invention relates to acyl-CoA-independent methods of producing fatty alcohols in recombinant host cells engineered to express an alcohol-forming acyl-ACP reductase. The recombinant host cells may be photosynthetic microorganisms, such as cyanobacteria. Isolated nucleic acid molecules, vectors, and recombinant host cells expressing an alcohol-forming acyl-ACP reductase, and systems for producing... Agent: Synthetic Genomics, Inc.

20130078687 - From carbon monoxide and hydrogen anaerobic fermentation processes using a pre-reactor/deep tank reactor system: Processes are disclosed for the low energy, anaerobic bioconversion of hydrogen and carbon monoxide in a gaseous substrate stream to oxygenated organic compounds such as ethanol by contact with microorganisms in a fermentation system with high conversion efficiency of both hydrogen and carbon monoxide. The processes of this invention use... Agent: Coskata Energy

20130078690 - Biological and chemical process utilizing chemoautotrophic microorganisms for the chemosythetic fixation of carbon dioxide and/or other inorganic carbon sources into organic compounds, and the generation of additional useful products: The invention described herein presents compositions and methods for a multistep biological and chemical process for the capture and conversion of carbon dioxide and/or other forms of inorganic carbon into organic chemicals including biofuels or other useful industrial, chemical, pharmaceutical, or biomass products. One or more process steps utilizes chemoautotrophic... Agent: Kiverdi, Inc.

20130078688 - Low energy, high substrate efficiency, anaerobic, deep, bubble column fermentation processes: Bioconversion processes are disclosed that enable high conversion efficiencies of gas substrate containing both carbon monoxide and hydrogen to oxygenated organic compounds via the carbon monoxide and hydrogen pathways using anaerobic, deep, bubble column fermentation in a cost effective manner. The high conversion efficiency processes of this invention comprise the... Agent: Coskata Energy

20130078689 - Processes for enhancing the performance of large-scale, stirred tank anaerobic fermentors and apparatus therefor: Processes and apparatus are disclosed for the low energy, anaerobic bioconversion of hydrogen and carbon monoxide in a gaseous substrate stream to oxygenated organic compounds such as ethanol by contact with microorganisms in a deep, stirred tank fermentation system with high conversion efficiency of both hydrogen and carbon monoxide. Gas... Agent: Coskata, Inc.

20130078691 - Microorganisms having enhanced resistance to acetate and related compositions and methods of use: The present invention provides isolated or genetically modified strains of microorganisms that display enhanced resistance to acetate as a result of increased expression of a sodium proton antiporter. The present invention also provides methods for producing such microbial strains, as well as related promoter sequences and expression vectors. Further, the... Agent: Ut-battelle, LLC

20130078692 - Ketoreductase polypeptides for the reduction of acetophenones: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent: Codexis, Inc.

20130078694 - Pantothenic acid biosynthesis in zymomonas: Zymomonas is unable to synthesize pantothenic acid and requires this essential vitamin in growth medium. Zymomonas strains transformed with an operon for expression of 2-dehydropantoate reductase and aspartate 1-decarboxylase were able to grow in medium lacking pantothenic acid. These strains may be used for ethanol production without pantothenic acid supplementation... Agent: E. I. Du Pont De Nemours And Company

20130078693 - Processes for starting up deep tank anaerobic fermentation reactors for making oxygenated organic compound from carbon monoxide and hydrogen: wherein the mass transfer of carbon monoxide to an aqueous menstruum in the reactor is controlled to obtain the robust growth of the microorganism while maintaining the carbon monoxide concentration below that amount which is unduly adverse to the microorganism. In preferred aspects of the invention, recycled gas from the... Agent: Coskata Energy

20130078697 - Fermentation system and fermentation method using saccharide solution: An alcohol production system that produces alcohol by alcoholic fermentation using a saccharide solution, including an alcoholic fermentation vessel in which the saccharide solution is fermented by adding yeast to produce alcohol, which is an organic feedstock, and a biomass-hydrothermally-treated-product adding means that adds a biomass hydrothermally-treated product obtained by... Agent: Mitsubishi Heavy Industries Mechatronics Systems,ltd.

20130078695 - Pretreatment method for producing water-soluble sugars from lignocellulosic material: The invention relates to manufacturing hydrolyzable cellulose and further, if desired, sugars from lignocellulosic material by means of formic and performic acid treatment.... Agent: Chempolis Oy

20130078698 - Process for fractionation of biomass: A process of fractionation of biomass using aqueous ammonia for fractionation of biomass into lignin, cellulose and/or hemicellulose is provided herein. The process disclosed in the present invention is recovers lignin, cellulose and hemicellulose in more than 90% purity. The present invention also provides process of saccharification and fermentation of... Agent:

20130078696 - Processing biomass: Carbon-containing materials, such as biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) or coal are processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol.... Agent: Xylceo Inc.

20130078699 - Compositions and methods for producing isoprene: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.... Agent: Danisco US Inc.

20130078700 - Method and system for the gas-tight process control of percolators in a biogas method having two or more stages: The invention relates to a method and a system for obtaining biogas in two or more stages in a hydrolysis and a methane stage, wherein the hydrolysis of solid biogenic materials is performed in at least two percolators operated at offset times. Liquid hydrolyzate and CO2 rich hydrolysis gas, and... Agent: Gicon Grossmann Ingenieur Consult Gmbh

20130078701 - Device comprising a conductive surface and a conductive polymer for adhesion of cells and tissue: The conductive polymer (14), in a first state, before applying the potential difference, exhibits a first adhesive capacity, wherein the conductive polymer layer (14) is substantially attached to the conductive substrate surface (19). In a second state, subsequent to application of the potential difference, the conductive polymer (14), exhibits a... Agent: Oboe Ipr Ab

20130078702 - Device for viral inactivation of liquid media: An apparatus (100) capable of viral inactivation of liquid media includes at least one coaxial cylinder (110) constructed of an outer cylinder (120) and an inner cylinder (130), a liquid media inlet (140), at least one emitter of type C ultraviolet radiation (145), and a liquid media outlet (150). The... Agent: Genzyme Corporation

20130078703 - Method of regenerating an enzymati catalyst: A method of regenerating an enzymatic catalyst arranged in a reactor includes a mineral support based on metal oxide and at least one enzyme, wherein it contains at least one step of detachment of the spent enzymes by solvation by scavenging of the catalyst using at least one ionic surfactant,... Agent: Total Raffinage Marketing

20130078704 - Processing chemicals: Methods of processing chemicals change their structure, and in particular increase their solubility and/or rate of dissolution, for intermediates and products made from the structurally changed materials. Many of the methods provide materials that can be more readily utilized in reactions or other processes to produce useful intermediates and products,... Agent: Xyleco, Inc.

20130078705 - Protease for treating nail abnormalities: A protease for treating nail abnormalities is a type of protease. Since nails are mostly composed of keratin protein, the optimum protease for decomposing the main component (keratin) of the nail is keratinase or serine protease which is functionally similar to keratinase. The serine protease include trypsin, chymotrypsin, elastase, subtilisin,... Agent:

20130078706 - Method of transforming cells: Use of an isolated Ensifer adhaerens strain OV14 deposited under NCIMB Accession Number 4177, or an isolated variant thereof characterised by a 16S rRNA gene having at least 98.6% sequence homology with SEQUENCE ID NO: 1, as a gene delivery system in the genetic transformation of a plant cell or... Agent: University College Dublin, National University Of Ireland

20130078708 - Continuous or semi-continuous flow photobioreactor and method of use: The present invention is directed to a photobioreactor for continuous or semi-continuous flow culturing photosynthesizing biomass and related method. In particular, the invention relates to a photobioreactor for continuous or semi-continuous flow culturing photosynthesizing algal biomass and related method. The photobioreactor comprises a gas feeding portion (60), a biomass-directing flow... Agent:

20130078707 - Novel radioresistant alga of the coccomyxa genus: The invention relates to novel algae of the Coccomyxa genus, in particular the algae of a novel species called Coccomyxa actinabiotis, and to the use thereof for metal uptake from aqueous media, and in particular from radioactive media.... Agent:

20130078709 - Nucleic acids useful in the manufacture of oil: Novel gene sequences from microalgae are disclosed, as well as novel gene sequences useful in the manufacture of triglyceride oils. Also disclosed are sequences and vectors that allow microalgae to be cultivated on sugar cane and sugar beets as a feedstock. In some embodiments, the vectors are useful for the... Agent: Solazyme, Inc.

20130078710 - Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ... Agent: Transmedics, Inc

20130078711 - Systems and methods for providing microfluidic devices: A microfluidic valve system is disclosed that includes a matrix, a hydrophilic acceptor region a hydrophilic transfer region, and a hydrophobic gap between the acceptor region and the transfer region.... Agent: Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations

20130078712 - Nucleic acid amplifier and nucleic acid inspection device employing the same: A nucleic acid amplifier comprises a holder 3 which is provided with a plurality of temperature control blocks 10 each designed to hold at least one reaction vessel 105 storing a reaction solution. The temperature of the reaction solution in each reaction vessel 105 is controlled individually by using temperature... Agent: Hitachi High-technologies Corporation

20130078714 - Culture apparatus provided with heat pipe: A culture apparatus includes a heat insulating box main body having an inner box; a culture vessel; a duct and a circulation blower forcing convection of a gas in the culture vessel; a humidifying pan disposed on the bottom of the culture vessel and positioned inside the duct; a heat... Agent: Panasonic Healthcare Co., Ltd.

20130078713 - Thermal cycler for pcr: An assembly for cycling vials of reaction mixtures through a series of temperature excursions is provided. The assembly can include a sample block for receiving the vials, a plurality of thermoelectric devices, a heat sink, and a clamping mechanism positioned to clamp the thermoelectric devices between the sample block and... Agent: Applied Biosystems, LLC

20130078715 - Anti-microrna oligonucleotide molecules: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.... Agent: Rockefeller University

20130078716 - Vcp-based vectors for algal cell transformation: Provided herein are exemplary vectors for transforming algal cells. In exemplary embodiments, the vector comprises a Violaxanthin-chlorophyll a binding protein (Vcp) promoter driving expression of an antibiotic resistance gene in an algal cell. Embodiments of the invention may be used to introduce a gene (or genes) into the alga Nannochloropsis,... Agent:

20130078717 - Binding members-513: This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a KD of 10 pM or less when measured by Kinexa™. The... Agent: Medimmune Limited

20130078718 - Conversion of vascular endothelial cells into multipotent stem-like cells: Disclosed herein is a method of producing multipotent cells, comprising, activating ALK2 of isolated endothelial cells in a serum starved environment, to thereby produce isolated multipotent cells. Activation can be following a threshold period of serum starvation. Activating ALK2 is by contacting the isolated endothelial cells with TGFβ-2 and/or BMP4.... Agent: President And Fellows Of Harvard College

20130078720 - Method for inducing pluripotency in human somatic cells with prdm14 or nfrkb: Methods of inducing pluripotency in human somatic cells and methods of maintaining pluripotency in human embryonic stem cells (hESCs) are provided, as well as cells and uses of employing such cells. The methods comprise culturing cells in the presence of (i) OCT4 and SOX2; (ii) at least one of KLF4... Agent: Agency For Science, Technology And Research

20130078719 - Novel shrna molecules and methods of use thereof: The present invention relates to certain novel shRNA molecules and methods of use thereof. According to certain embodiments of the present invention, methods for reducing the expression level of a target gene are provided. Such methods generally comprise providing a cell with one or more precursor nucleic acid sequences that... Agent: Gradalis, Inc.

20130078721 - Cell culture medium for the growth and differentiation of cells of the hematopoietic lineage: The present invention relates to a cell culture medium for the growth and/or differentiation of cells of the hematopoietic lineage, comprising: —insulin at a concentration of from 1 to 50 μg/ml; —transferrin at a concentration of from 100 μg/ml to 2000 μg/ml; and—plasma or serum at a concentration of from... Agent:

20130078722 - Methods of multiplying conifer embryogenic tissue: The invention provides methods for multiplying conifer embryogenic tissue. The methods of the invention comprise the steps of: (a) culturing conifer embryogenic tissue in or on a solid multiplication medium comprising one or more growth hormones; and (b) culturing the conifer embryogenic tissue multiplied in step (a) in or on... Agent: Weyerhaeuser Nr Company

20130078723 - Genetic material manipulation techniques and products thereof: The presently claimed invention applies to a genetic material processing and manipulation method and related product. The claimed invention relates to a method for changing the inherited characteristics of a cell through micro-beam chromosome modification. In one preferred embodiment, improvements to ‘genomic surgery’ are applied to modify source cell genetic... Agent:

20130071834 - Compositions and methods useful for hcv infection: The present invention provides compositions comprising cells that can effectively produce HCV after HCV infection, compositions for culturing the cells, methods for making the composition and methods for infecting the cells in the composition with HCV. The present invention also provides methods for assaying HCV production and methods for evaluating... Agent: Vertex Pharmaceuticals Incorporated

20130071833 - Means and methods for distinguishing fecv and fipv: The invention provides methods and means for distinguishing FECV and FIPV, and methods and means for determining whether FIPV is present in a sample. Further provided are primers and probes for detecting FIPV specific nucleic acid sequences encoding a spike protein, antibodies for detecting a FIPV, and an immunogenic composition... Agent: Universiteit Utrecht Holding B.v.

20130071835 - Qualitative and quantitative analytical method for analyzing the activity type of an enzyme that is activated by proteolysis: The present invention relates to a qualitative and quantitative analytical method for analyzing the activity type of an enzyme that is activated by proteolysis. The method of the present invention is advantageous in that the activity type of an enzyme present in a specimen is analyzed using an enzyme activity... Agent: Nanoenteck, Inc.

20130071836 - Colon cancer biomarker discovery: The present application discloses an epigenetic marker for colon cancer.... Agent:

20130071840 - Enhanced detection of non-somatic circulating nucleic acids: Methods, equipment and software for the detection of abnormal nucleic acid or fetal nucleic acid sequences circulating in the subject's blood or other body fluids. A scan of a subject's circulating nucleic acid (CNA) is compared to the CNA Data On Normal Healthy Population or to a scan of the... Agent:

20130071842 - Hypermethylation biomarkers for detection of head and neck squamous cell cancer: Differentially methylated oral squamous cell carcinoma (OSCC) biomarkers, identified in-vitro and validated in well-characterized surgical specimens, have shown poor clinical correlation in cohorts with different risk profiles. To overcome this lack of relevance we used the HumanMethylation27 BeadChip, publicly available methylation and expression array data, and Quantitative Methylation Specific PCR... Agent: The Johns Hopkins University

20130071845 - Identification of human mouse double minute 2 homolog nucleotide sequences: The invention is directed to isolated genomic polynucleotide fragments that encode human carboxypeptidase M and human mouse double minute 2 homolog, vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments. The invention is further directed to methods of using... Agent: Ryogen LLC

20130071846 - Kit and method: The present invention relates to a kit comprising a DNA-dependant DNA polymerase and at least one natural deoxynucleoside and to a kit comprising a DNA-dependent DNA polymerase and a detection system comprising a DNA template molecule, a DNA primer molecule, and a fluorescent moiety capable of being displaced from,or bound... Agent:

20130071837 - Method and system for characterizing or identifying molecules and molecular mixtures: A system and method for identifying a material passing through a nanopore filter wherein an electrical signal is detected as a result of the passage and that signal is processed in real-time using mathematical and statistical tools to identify the molecule. A carrier molecule is preferably attached to one or... Agent:

20130071844 - Method for detecting target base sequence using competitive primer: Disclosed is a method of detecting a target base sequence having a polymorphic base, the method including: (a) a step of adding to a nucleic acid sample having a target nucleic acid that includes a base sequence including the target base sequence: at least one type of detection primer, at... Agent: Toppan Printing Co., Ltd.

20130071843 - Methods, probe sets, and kits for detection of deletion of tumor suppressor genes by fluorescence in situ hybridization: Methods, probe sets, kits, and compositions for gene deletion assays are disclosed. In some embodiments, the methods relate to preparing probes for a deletion assay, performing a deletion assay, or optimizing a deletion assay. In some embodiments, the methods and probe sets can provide reduced artifactual deletion frequency, for example,... Agent:

20130071838 - Peptide nucleic acid probes for analysis of certain staphylococcus species: The present invention relates to peptide nucleic acid (PNA) probes, PNA probe sets and methods for the analysis of certain Staphylococcus species optionally present in a sample. The invention further relates to diagnostic kits comprising such PNA probes or PNA probe sets.... Agent: Advandx, Inc.

20130071839 - Systems and methods for detecting biomarkers of interest: In some embodiments, a strand displacement system is provided. Such a system may include a first nucleic acid catalyst molecule; a nucleic acid gate molecule, wherein the first nucleic acid catalyst molecule binds the nucleic acid gate molecule forming a nucleic acid gate-catalyst complex and releases an output molecule; and... Agent:

20130071841 - Translocation and mutant ros kinase in human non-small cell lung carcinoma: In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of Sodium-dependent Phosphate Transporter Isoform NaPi-3b protein (SLC34A2) with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The SLC34A2-ROS fusion... Agent: Cell Signaling Technology, Inc.

20130071852 - Controls for detecting methicillin resistant staphylococcus aureus (mrsa): The invention relates to the quality control of Staphylococcus aureus testing using nucleic acid amplification-based detection assays. A Staphylococcus aureus control containing a quantified amount of the microorganism with high reproducibility across vials and which is used to calibrate, validate, or verify the performance of an MRSA detection assay and... Agent: Life Technologies Corporation

20130071849 - Fret-labeled compounds and uses therefor: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other... Agent: Pacific Biosciences Of California, Inc.

20130071847 - Methods and materials for determining the source of waste: A method for identifying the source of animal waste is provided. The method includes taking DNA samples from a known group of animals, conducting DNA analysis on the DNA samples to prepare a genetic profile for each animal from the group, preparing a database of the genetic profiles, collecting a... Agent: Biopet Vet Lab

20130071851 - Moving microdroplets in a microfluidic device: The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms a fluid network through which fluid flows, and a... Agent: Handylab, Inc.

20130071848 - One-step method for quantitative determination of uracil in dna by real-time pcr: Uracil may occur in DNA due to either cytosine deamination or thymine replacing incorporation. Its quantitative characterization is important in assessing DNA damages in cells with perturbed thymidylate metabolism or within different DNA segments involved in immunoglobulin gene diversification. The archaeal DNA polymerase from Pyrococcus furiosus binds strongly to the... Agent:

20130071850 - Waveguide-based optical scanning systems: A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning senor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of... Agent:

20130071853 - Methods for identifying compositions that alter wildtype expression of genes and proteins in a plant cell: A method for identifying compounds that selectively alter wildtype gene expression of a plant cell includes comparing a first expression profile from a plant cell or tissue contacted with a first test compound, an additional expression profile from the same plant cell or tissue contacted with an additional test compound,... Agent: Rohm And Haas Company

20130071858 - Automated staining system and reaction chamber: An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid... Agent: Sakura Finetek U.s.a., Inc.

20130071859 - Methods of determining patient response by measurement of her-3: The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3.... Agent: Laboratory Corporation Of America Holdings

20130071860 - Methods for autoimmune disease diagnosis, prognosis, and treatment`: In one aspect, the present invention provides methods for the classification, diagnosis, prognosis, theranosis, and/or prediction of an outcome of an autoimmune disease in a subject.... Agent:

20130071855 - Flc as biomarker: The invention provides a method of identifying a subject likely to have liver disease, or for determining the prognosis of a subject previously identified as having a liver disease comprising detecting an amount of free light chains in a sample from the subject, wherein a higher amount of FLC is... Agent: The Binding Site Group Limited

20130071854 - Methods for the identification and characterization of hdac interacting compounds: The present invention relates to methods for the identification and characterization (e.g. selectivity profiling) of HDAC interacting compounds using protein preparations derived from cells endogenously expressing HDACs or cell preparations containing said HDACs.... Agent:

20130071856 - Method and biomarker for evaluating metastasis, and sirna compound for inhibiting metastasis: A method and biomarker for evaluating metastasis, and an siRNA compound for inhibiting metastasis. The method of the present invention includes: providing a sample of a subject, which includes a normal tissue and a tissue to be detected; detecting expression of a biomarker of the normal tissue and the tissue... Agent:

20130071857 - Biomarkers of gastric cancer and use thereof: A set of biomarkers indicative of early gastric cancer and method of diagnosing gastric cancer at an early stage by directing the these biomarkers in a blood sample. Detection of over-expression of one or more protein biomarks in the group consisting albumin, T-kininogen I, α-2-HS glycoprotein, α-1-antitrypsin, afamin and γ-actin... Agent:

20130071864 - Colorectal cancer marker vitronectin and method for analyzing vitronectin concentration in blood sample: The present invention provides a tumor screening marker that can be actually used in clinical practice to detect colorectal cancer, and a tumor progression marker that can complement CEA or CA19-9. Vitronectin for use as a tumor progression marker, a tumor screening marker or a prognostic prediction marker for colorectal... Agent:

20130071862 - Fusion proteins and their use in the diagnosis and treatment of leishmaniasis: The present invention relates generally to a fusion protein made from a synthetic gene construct comprising of elements derived from the Leishmania antigens K26, K39, and K9. The fusion protein is particularly useful in the diagnosis of leishmaniasis, particularly visceral leishmaniasis in animals such as humans and dogs.... Agent: Infectious Disease Research Institute

20130071861 - Methods and kits for detecting ita in a biological sample: Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect pregnancy, trophoblastic diseases, and Down's syndrome in fetuses of pregnant women. Some methods include screening the samples with a plurality of... Agent: Quest Diagnostics Investments Incorporated

20130071863 - Sulfur-containing amino acid derivative: The present invention provides a method of measuring an endogenous low-molecular-weight compound specifically and conveniently with high sensitivity. Using the particular sulfur-containing amino acid derivative, a method of measuring an endogenous low-molecular-weight compound specifically and conveniently with high sensitivity can be provided.... Agent: Ajinomoto Co., Inc.

20130071865 - Devices and methods for detecting amniotic fluid in vaginal secretions: The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies.... Agent: N-dia, Inc.

20130071866 - Method for testing the severtiy of an illness: An object of the present invention is directed to a method for assaying the severity of an illness in real time and is to provide a testing method capable of assessing the severity of an illness in more detail than the conventional APACHE II and SOFA scores. The established method... Agent: The University Of Tokushima

20130071867 - Method and apparatus for performing mass spectrometry: The invention feature devices and methods for preserving and processing samples comprising a fluid having deuterated compounds. The device of the present invention comprises a housing defining a first chamber and a second chamber. The first chamber is heated to an elevated temperature and receives the sample and performs a... Agent: Waters Technologies Corporation

20130071869 - Analysis compensation including segmented signals: A biosensor system determines analyte concentration from an output signal generated from a light-identifiable species or a redox reaction of the analyte. The biosensor system compensates at least 50% of the total error in the output signal with a primary function and may compensate a portion of the residual error... Agent: Bayer Healthcare LLC

20130071870 - Method for determining the stability of organic methyleneamines in the presence of semicarbazide-sensitive amine oxidase: The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing a methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.... Agent: Sanofi

20130071868 - Mutant lactate oxidase with increased stability and product, methods and uses involving the same: The present disclosure relates to a mutant lactate oxidase having increased stability, a nucleic acid encoding the mutant lactate oxidase, an expression vector comprising the nucleic acid, a host cell comprising the nucleic acid or the expression vector, a method of determining lactate in a sample, the use of the... Agent: Roche Diagnostics Operations, Inc.

20130071871 - Enzymatic determination of lithium ions using phosphoglucomutase: Kits and methods for measuring lithium ions using phosphoglucomutase are disclosed.... Agent: Specialty Assays, Inc.

20130071873 - Array microinjection apparatuses and methods: An array microinjection apparatus comprises a substrate (10) defining an in-use upper surface (11) having formed therein a plurality of part-spherical recesses (12). Each of these includes an in-use upwardly facing opening (13), the dimensions of the recesses (12) being such that each said recess accommodates therein a single cell;... Agent: Universiteit Leiden

20130071872 - Device and method for single-used matrix sampling: A single-used matrix sampling device for the single-used, disposable or autoclavble packed-bed bioreactor is provided herein. The present invention includes a tube means and a matrix collecting means. The matrix collecting means configured for collecting the cell culture matrix includes a receptacle and a pulling means connected to the receptacle... Agent:

20130071874 - System and method for anti-cancer drug candidate evaluation: The disclosure provides a method of evaluating the ability of an anti-cancer drug candidate to induce apoptosis in a known cancer cell line by placing a single-cell suspension of a known cancer cell line in a well of a plate, adding at least one drug candidate to the well in... Agent: Diatech Oncology, LLC

20130071875 - Method and system for the detections of biological objects: The present invention provides a method for identifying biological objects on a substrate; the method comprises: (i) illuminating the substrate carrying the biological objects with a light beam; (ii) acquiring at least one optical image of the illuminated substrate; the light beam comprises a wavelength band, the wavelength band is... Agent: Vbact Ltd.

20130071876 - Method for utilizing soft x-ray microimaging for cancer cell image recognition: This invention discloses a method for utilizing soft X-ray microimaging for cancer cell image recognition. The method comprises the steps of 1) sample preparation; 2) pathological examination; 3) soft X-ray imaging; and 4) analysis and recognition. This invention applies soft X-ray microimaging for cancer cell image recognition, successfully obtains the... Agent: No. 128 Hospital Of Hangzhou

20130071877 - Chimeric isoprenoid synthases and uses thereof: Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of... Agent:

20130071878 - Two helix binders: Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders,... Agent: General Electric Company

20130071879 - Amplification methods to minimise sequence specific bias: Methods for amplifying nucleic acids are provided. The methods can be used to minimise sequence specific bias caused by the preferential amplification of certain nucleic acid sequences. Methods are described which can lower the efficiency of AT rich templates relative to GC rich templates, thereby minimising GC bias during amplification... Agent: Illumina Cambridge Limited

20130071880 - Dna amplification apparatus and method: The invention relates to a method for the amplification of DNA and apparatus for such amplification. The method comprises steps typically found in amplification methods but utilises an optical procedure to detect denaturation of DNA or attainment of the desired denaturation temperature. The apparatus (1) comprises a temperature controllable chamber... Agent: Corbett Life Science Pty Ltd

20130071881 - Methods for producing antibody-producing cells that produce desired polypeptides: An objective of the present invention is to provide methods for introducing DNAs encoding a desired amino acid sequence into a region comprising a DNA encoding an antibody variable region of antibody-producing cells. The present inventors developed methods for efficiently introducing DNAs encoding a desired amino acid sequence into the... Agent: Immuno Tec Laboratory Co. Ltd

20130071882 - Collective chirality of binary plasmonic nanoparticles janus assemblies: Multiple properties of plasmonic assemblies are determined by their geometrical organization. This patent focuses on the formation of Janus structure of the asymmetric assembly structure of the gold nanorods and gold nanoparticles. Chiral structure of gold nanorods and gold nanoparticles can be obtained through the characterization of optical spectra of... Agent:

20130071883 - Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol: The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2... Agent: Genomatica, Inc.

20130071884 - Plants expressing cell wall degrading enzymes and expression vectors: Vectors for expression of proteins in plants are described. The proteins may be enzymes and the enzymes can be but are not limited to cell wall degrading enzymes. A number of plants designed to express specific cell wall degrading enzymes are provided. The plants may have industrial and/or agricultural applications.... Agent: Agrivida, Inc.

20130071885 - Acyl amino acids: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.... Agent:

20130071886 - Microorganisms for the production of 1,4-butanediol: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.... Agent: Genomatica, Inc.

20130071887 - Enzymatic cleavage of stevioside to produce steviol: This invention is directed to a process for cleaving glycoside residues from stevioside to produce steviol using a commercially available enzyme mixture containing pectinase, CYTOLASE PCL5®. In preferred methods, the reaction takes place in the presence of a yeast culture. Also described are combinations of Helix pomatia enzymes and CYTOLASE... Agent: DsmIPAssets B.v.

20130071888 - Method for producing 1,5-pentanediamine: A method of producing 1,5-pentanediamine includes culturing coryneform bacterium having a gene encoding lysine decarboxylase in its chromosome, which coryneform bacterium maintains lysine decarboxylase activity of not less than 50 mU/mg protein during culturing and the gene encoding lysine decarboxylase is linked downstream of a promoter that functions during the... Agent: Toray Industries, Inc.

20130071889 - Production method for biofuel: The present invention provides a production method for biofuel based on a technology to convert carbon-dioxide as a carbon source through photosynthesis by photosynthetic microorganisms to biomass and produce biofuel of the biomass. The production method for biofuel of the present invention comprises a culturing process (S1) of culturing in... Agent:

20130071891 - In situ expression of lipase for enzymatic production of alcohol esters during fermentation: Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity.... Agent: Butamax(tm) Advanced Biofuels LLC

20130071892 - Process for production of polyhydroxyalkanoic acid using genetically modified microorganism having enoyl-coa hydratase gene introduced therein: The present invention intends to produce poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] with a high 3-hydroxyhexanoic acid fraction using a vegetable oil as a basic raw material. In accordance with the present invention, there is provided a method of producing a microorganism that produces poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) with a high 3-hydroxyhexanoic acid fraction using a vegetable... Agent: Tokyo Institute Of Technology

20130071890 - Production of pha using biogas as feedstock and power source: Methods for producing bioplastics from biogas include techniques for the production of PHB using a dirty biogas (e.g., methane from landfill, digester) as both a power source for the process and as feedstock. Biogas is split into two streams, one for energy to drive the process, another as feedstock. Advantageously,... Agent:

20130071893 - Methods for producing 3-hydroxypropionic acid and other products: This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid.... Agent: Opx Biotechnologies, Inc.

20130071894 - Glucose valve and other metabolite valves: Aspects of the invention relate to the design and construction of Metabolite Valves, such as Glucose Valves, that can be used to divert metabolites from endogenous pathways toward alternative pathways in a cell.... Agent: Massachusetts Institute Of Technology

20130071895 - L-lactate production in cyanobacteria: A process of producing L-lactate as defined herein by feeding carbon dioxide to a culture of a cyanobacterial cell and subjecting said culture to light, wherein said cell is capable of expressing a nucleic acid molecule, wherein the expression of said nucleic acid molecule confer on the cell the ability... Agent: Photanol B.v.

20130071896 - Method for controlling undesirable byproducts formation caused by contaminating organisms in the production of ethanol from syngas: A method of operating a fermentation zone for the production of ethanol from syngas uses a crotonate derivative to prevent or reverse the effects of butyrigen contamination. The crotonate compound works in continuous fermentation processes to reduce or eliminate contamination from butyrate and butanol in the syngas derived ethanol product.... Agent:

20130071897 - Method for controlling undesirable byproducts formation caused by contaminating organisms in the production of ethanol from syngas: A method of operating a fermentation zone for the production of ethanol from syngas uses a crotonate-like compound to prevent or reverse the effects of butyrogen contamination. The crotonate-like compound works in continuous fermentation processes to reduce or eliminate contamination from butyrate and butanol in the syngas derived ethanol product.... Agent: Coskata, Inc.

20130071898 - Host cells and methods for production of isobutanol: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having... Agent: Butamax(tm) Advanced Biofuels LLC

20130071899 - Process for producing aliskiren: A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described.... Agent: Chemo Iberica, S.a.

20130071900 - Process for processing a lignocellulosic material: Calcium-containing lignocellulosic material is converted at a temperature in the range from equal to or more than 120° C. to equal to or less than 210° C. with an aqueous acid solution containing one or more inorganic acids and having a pH in the range from equal to or more... Agent: Shell Oil Company

20130071901 - Process for the conversion of a xylan-containing feed: A xylan-containing feed is contacted, in the first reactor essentially operated at plug flow, with an aqueous solution of an acid at a temperature in the range from equal to or more than 140° C. to equal to or less than 210° C. to produce an intermediate product. Then, the... Agent: Shell Oil Company

20130071902 - Method and system for collecting water from an aquatic cell: Methods and systems for collecting, purifying, and/or extracting ethanol produced during anaerobic metabolism by aquatic plants is provided. The system includes a cell containing water and an aquatic plant, an ethanol extraction assembly in fluid communication with the cell for removing ethanol from the water. Ethanol is released by the... Agent: Aquatech Bioenergy LLC

20130071903 - Method for heating a feedstock: The present invention provides a method for producing a pretreated or hydrolyzed lignocellulosic feedstock. The method comprises feeding a lignocellulosic feedstock to a plug formation device and forming a feedstock plug therein. The plug or segments thereof are fed into an elongate chamber that comprises steam addition means for direct... Agent: Iogen Energy Corporation

20130071904 - Acetate-resistant yeast strain for the production of a fermentation product: The present invention provides methods and compositions for fermentations comprising acetate-resistant yeast. The present invention provides methods for use of acetate-resistant yeast for the production of fermentation products.... Agent:

20130071905 - Plasma irradiation device for substance introduction and substance introduction method using plasma irradiation device: Disclosed is a liquid culture medium for substance introduction, which is capable of increasing the survival rate of cells after substance introduction as much as possible when the cells are irradiated with plasma for the purpose of introducing a target substance into each of the cells. Specifically disclosed is a... Agent: National University Corporation Kumamoto University

20130071906 - Cell culture medium for adamts protein expression: The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high... Agent: Baxter International Inc.

20130071907 - Bile resistant bacillus composition secreting high levels of phytase: A bacillus composition characterized by fast germination and outgrowth in bile salts (simulated gut environment) and by high-level secretion of phytase. The bacillus composition may be used as supplement in animal feed where it has a probiotic (health promoting) effect and increases the digestion and availability of nutrients from animal... Agent: Chr. Hansen A/s

20130071908 - Compositions and methods for producing isoprene: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.... Agent: Danisco US Inc.

20130071909 - Heterotrophic cultivation of hydrocarbon-producing microalgae: The invention discloses novel methods of producing hydrocarbons through heterotrophic cultivation of Botryococcus braunii. Also provided are novel hydrocarbon compositions. A preferred species for engineering is the microalgae species Botryococcus braunii. Additional methods of cultivation include providing certain nutrient sources.... Agent: Solazyme, Inc.

20130071910 - Storage-stable liquid detergent or cleaning agent containing protease and lipase: The object is to improve the storage stability of a liquid washing or cleaning agent comprising a protease and lipase with regard to lipolytic activity. This is achieved through the use of a protease comprising an amino acid sequence that is at least 80% identical to the amino acid sequence... Agent: Henkel Ag & Co. Kgaa

20130071911 - Method for paper treatment with enzyme: Exemplary embodiments provide methods for treating a xerographic printed substrate with an enzyme solution to increase the surface free energy of the substrate. Other exemplary embodiments provide methods for making an adhesive medium with an enzyme-treated substrate.... Agent: Xerox Corporation

20130071912 - Methods and apparatus of controlling surface wettability of xerographic prints: Exemplary embodiments provide methods and apparatus of using an enzyme-surfactant solution to control surface wettability of a xerographic print.... Agent: Xerox Corporation

20130071913 - Use of amylase variants at low temperature: The present invention relates to the use of alpha-amylase variants having improved activity relative to the parent enzyme at low temperature, including improved washing and/or dishwashing performance and/or increased stability at low temperature. The invention further relates a method for doing laundry, dish wash and/or cleaning such as institutional cleaning... Agent: Novozymes A/s

20130071914 - Method for studying floating, living cells: Disclosed is a method of studying floating living cell by confining the cells floating in an aqueous medium in picowells located on a bottom surface of a top wall of a chamber. Disclosed is also a picowell-bearing device for the study of cells comprising a chamber having at least one... Agent: Seng Enterprises Ltd.

20130071915 - Microwell structures for chemically-sensitive sensor arrays: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.... Agent: Life Technologies Corporation

20130071916 - Synthetic coating for cell culture: A method for coating a surface of a cell culture article includes dissolving a polymer having a covalently attached polypeptide in an aqueous solution to produce a polymer solution. The polymer is formed from monomers selected to form a polymer having a linear backbone, wherein the polymer is crosslink free.... Agent:

20130071917 - Capillary for apparatus of insulated isothermal polymerase chain reaction: A capillary for apparatus of insulated isothermal polymerase chain reaction is mounted onto a test tube holder. The capillary includes a tube which has an elongated tubular housing space that is cut to form an axial cross section with a distance between left and right edges greater than the distance... Agent:

20130071918 - Cell culture container and method for fabricating the same: The present invention relates to a cell culture container, which enhances the efficiency of proliferation and differentiation of various cells including stem cells. The cell culture container according to an exemplary embodiment of the present invention includes a cell culture surface for adhering adult stem cells thereon to proliferate and... Agent: Postech Academy-industry Foundation

20130071920 - Mesenchymal stem cell attractant and method for attracting mesenchymal stem cell: The present invention aims to provide a mesenchymal stem cell attractant capable of attracting a mesenchymal stem cell; and others. The present invention provides a mesenchymal stem cell attractant containing at least one selected from the group consisting of an extract of a Bodhi tree, an extract of the root... Agent: Pias Corporation

20130071919 - Method of selecting induced pluripotent stem cell: The present invention provides a method of selecting a highly safe induced pluripotent stem cell, which includes comprehensively detecting the sequence of an expression vector used for induction of the induced pluripotent stem cell, in the nucleic acid in the cell, and a kit used for the method.... Agent: Kyoto University

20130071921 - Antibodies specific for dkk-1 and their uses: The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided are antibodies and fragments thereof which compete... Agent: Pfizer Inc.

20130071922 - Anti-c5 alpha antibodies: The present invention refers to recombinant antibodies of human origin specific for the C5 component of the activated complement and characterised by the ability to inhibit the conversion of the C5 alpha chain to C5a and C5b. Moreover the present invention refers to the nucleotide sequences coding for such antibodies... Agent: Adienne Srl

20130071923 - Human gm-csf antigen binding proteins: Antigen binding proteins that bind to human GM-CSF protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of GM-CSF to GM-CSFR, inhibit GM-CSF-induced proliferation and signaling of myeloid lineage cell lines and inhibit... Agent: Amgen Inc.

20130071924 - Cells exhibiting neuronal progenitor cell characteristics and methods of making them: Disclosed are cells exhibiting neuronal progenitor cell characteristics, and methods of making them from marrow adherent stem cells by regulating cellular pathways in the marrow adherent stem cells that are associated with glial transdifferentiation of the marrow adherent stem cells.... Agent: Sanbio, Inc.

20130071925 - Cell culture medium: The present invention relates to a cell culture medium for culturing human cells comprising an anti-coagulated total blood material wherein the hemoglobin level is from about 8 to about 16 g/dl. More particularly, the invention provides a cell culture medium in which cells present in the blood are disrupted and... Agent:

20130071926 - Compositions and methods for growing human embryonic cells: Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic germ (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or... Agent:

20130071927 - Media and methods for cell culture: The present invention provides a cell passaging medium comprising at least one agent capable of detaching from a surface a cell that is culture in vitro on said surface, and a water-soluble polymer capable of protecting the detached cell. The present invention also provides a cell culturing medium comprising one... Agent: Sydney Ivf Limited

20130071928 - Novel shrna molecules and methods of use thereof: The present invention relates to certain novel shRNA molecules and methods of use thereof. According to certain embodiments of the present invention, methods for reducing the expression level of a target gene are provided. Such methods generally comprise providing a cell with one or more precursor nucleic acid sequences that... Agent: Gradalis, Inc.

20130071929 - Remedy for chronic inflammation and antibody to be used therein: The invention provides a remedy for chronic inflammation and an anti-TNIIIA2 antibody to be used therein. The remedy includes an antibody recognizing TNIIIA2, that is a peptide derived from a partial sequence A2 of a human tenascin-C fibronectin III-like repetitive sequence and having the amino acid sequence RSTDLPGLKAATHYTITIRGVC (SEQ ID... Agent: Tokyo University Of Science Educational Foundation

20130071932 - Culture method for causing differentiation of pluripotent mammalian cells: Provided is a method that achieves control of embryoid body size and can induce differentiation in a state where the embryoid body size is controlled, by using a cell culture chamber having a plurality of microchambers formed therein. A culture method for causing differentiation of pluripotent mammalian cells uses a... Agent: Kuraray Co., Ltd.

20130071930 - Polyesters, methods of making polyesters and uses therefor: Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue engineering bioscaffold and as a drug-delivery vehicle.... Agent: University Of Pittsburgh - Of The Commonwealth System Of Higher Education

20130071931 - Process for hepatic differentiation from induced hepatic stem cells, and induced hepatic progenitor cells differentiated thereby: A method for hepatic differentiation of a stem cell selected from among embryonic stem cells, induced pluripotent stem cells or induced hepatic stem cells is presented. More specifically, a stem cell selected from among embryonic stem cells, induced pluripotent stem cells or induced hepatic stem cells is cultured for 1... Agent: National Cancer Center

20130071933 - Citrus shoot regeneration compositions, methods, and systems: The present disclosure relates, according to some embodiments, to citrus shoot regeneration compositions, methods, and systems. For example, citrus shoot regeneration compositions (e.g., culture media) may comprise one or more non-ionic surfactants. Methods may comprise preparing and using these compositions in some embodiments. Regeneration systems may comprise, in some embodiments,... Agent: The Texas A&m University System

20130065218 - Medical fluid, a method of treatment and use of the fluid: A medical fluid for a harvested organ, tissue or parts thereof, for evaluation and/or preservation. The fluid includes cocaine or a stimulating analogue thereof; nor-adrenalin; and/or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients... Agent: Vivoline Medical Ab

20130065217 - Organ protection solution and method of use: An organ protectant solution which is intravenously administerable includes a high concentration of cell impermeant molecules which have a charge and/or molecular weight which permit passage across a capillary endothelium and into an interstitial space in said subject but which are too large and/or charged to cross a cell plasma... Agent:

20130065219 - Nutrient monitoring and feedback control for increased bioproduct production: The present invention pertains to methods of increasing the efficiency of producing a bioproduct. In some embodiments, the method increases the quantity of a bioproduct produced, or decreases bioproduct production time, in a bioreactor cell culture producing the bioproduct, the method comprising, (a) intermittently or continuously analyzing the concentration of... Agent: Biogen Idec Ma Inc.

20130065222 - Compositions, methods and reaction mixtures for the detection of murine leukemia virus-related virus: The present invention relates to the detection of infectious agents, more specifically to the detection of murine leukemia viruses and other highly related viruses, including but not limited to ecotropic murine leukemia viruses, xenotropic murine leukemia viruses, and polytropic murine leukemia viruses. Compositions, methods, reaction mixtures and kits are described... Agent: Gen-probe Incorporated

20130065221 - Hmgb1 and anti-hmgb1 antibodies for the prognostic of neurological disorders: The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a patient, and the use of this method in the prognostic and/or diagnosis of neurological... Agent:

20130065220 - Method of rapidly detecting microorganisms using nanoparticles: The present invention detects microorganisms using nanoparticles having immobilized thereon an antibody that binds specifically to the microorganisms to be detected, so that the presence and concentration of the microorganisms can be determined in a more effective and simpler manner than a conventional detection method, and the inventive method is... Agent: Korea Research Institute Of Bioscience And Biotechnology

20130065224 - Personal glucose meters for detection and quantification of a broad range of analytes: A general methodology for the development of highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method uses recognition molecules that are specific for a target agent, enzymes that can... Agent:

20130065223 - Universally applicable lysis buffer and processing methods for the lysis of bodily samples: The present invention provides a universally applicable lysis buffer comprising a chaotropic 5 agent, a reducing agent, and a proteolytic enzyme suitable for processing a wide variety o different sample types, such as different types of bodily samples relevant for the diagnosis o a respiratory disease. Furthermore, the present invention... Agent: Curetis Ag

20130065226 - Method of determining dose and administration of statin: The object is achieved by the method of determining the dose and/or administration of statins to a patient suffering from a cardiovascular disease comprising Step (1) of measuring the intracellular SmgGDS expression level of a patient suffering from a cardiovascular disease before and after administration of statin; and Step (2)... Agent: Tohoku University

20130065227 - Methods of increasing macropinocytosis in cancer cells: This disclosure describes methods of stimulating macropinocytosis in cancer cells.... Agent:

20130065225 - Reversible di-nucleotide terminator sequencing: The present teachings provide methods, compositions, and kits for synthesizing and sequencing nucleic acids. In some embodiments, reversible di-nucleotide compounds are employed along with cleaving reactions that remove a label and a blocking moiety. Improved sequencing efficiency is achieved by the rapid polymerase-mediated incorporation of reversible di-nucleotide compounds. In some... Agent: Life Technologies Corporation

20130065232 - Assays and kits for serotyping pseudomonas aeruginosa and oligonucleotide sequences useful in such methods and kits: The present invention relates to assays, kits and oligonucleotides for the detection of Pseudomonas aeruginosa for a fast, sensitive and reliable detection of Pseudomonas aeruginosa in a species- and serotype-specific manner. In particular, the present invention provides an assay for the serotype-specific detection of Pseudomonas aeruginosa, a kit for the... Agent: Kenta Biotech Ag

20130065235 - Binding and functional assays that use the t1r3 receptor to screen for taste modulatory compounds: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent:

20130065229 - Biomarkers for systemic lupus erythematosus: The present invention provides methods and reagents for diagnosing system lupus erythematosus and for monitoring system lupus erythematosus disease activity in a subject.... Agent: Exagen Diagnostics, Inc.

20130065233 - Detection of dna methylation: In a first aspect, the invention concerns a method for detecting or quantifying DNA methylation at a locus. In one embodiment, a methylation-sensitive endonuclease is formulated together with a polymerase enzyme in an appropriate reaction mixture such that amplification of DNA occurs in a methylation specific manor. Quantitative DNA amplification... Agent: Zymo Research Corporation

20130065228 - Genome-scale analysis of aberrant dna methylation in colorectal cancer: Particular aspects provide methods and compositions (e.g., gene marker panels) having substantial utility for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive DNA methylation-based subgroups of CRC including CpG island methylator phenotype (CIMP) groups (e.g., CIMP-H and CIMP-L) and non-CIMP groups.... Agent: University Of Southern California

20130065234 - Method for diagnosing bone and joint disease based on single nucleotide polymorphism in chromosome 10q24: Provided is a method for diagnosing a bone and joint is disease such as scoliosis. A single nucleotide polymorphism present in region 24 on the long arm of chromosome 10 (region 10q24) is analyzed and the risk of onset of a bone and joint disease and/or the presence or absence... Agent: Riken

20130065236 - Method for real-time nucleic acid amplification by droplet manipulation: The present invention provides a real-time nucleic acid amplification method capable of quickly and accurately detecting fluorescence obtained by a nucleic acid amplification method performed in a droplet in a perfect closed system. A real-time nucleic acid amplification reaction method for performing a nucleic acid amplification reaction in a droplet... Agent: Shimadzu Corporation

20130065237 - Novel mixtures for assaying nucleic acid, novel method of assaying nucleic acid with the use of the same and nucleic acid probe to be used therefor: [Means for Solving Problems] 1) A mixture which comprises one internal standard nucleic acid and two nucleic acid probes labeled with a fluorescent dye; 2) a mixture for measuring Km value which comprises one internal standard nucleic acid having a partial mutation and one nucleic acid probe labeled with a... Agent:

20130065231 - Primer and probe for use in detection of mycobacterium kansasii and method for detection of mycobacterium kansasii using the same: The methods enable the detection of M. kansasii more rapidly and with higher accuracy compared with conventional methods performed by culture. Further, the methods can exclude false positive results for the diagnosis and can also detect and diagnose M. kansasii with higher accuracy compared with methods performed by PCR using... Agent: Wako Pure Chemical Industries, Ltd.

20130065230 - Soybean event pdab9582.814.19.1 detection method: Soybean Event pDAB9582.814.19.1 comprises genes encoding Cry1F, Cry1Ac (synpro), and PAT, affording insect resistance and herbicide tolerance to soybean crops containing the event, and enabling methods for crop protection and protection of stored products. The invention provides PCR event detection methods.... Agent: Dow Agrosciences LLC

20130065238 - Syngap1 dysfunctions and uses thereof in diagnostic and therapeutic applications for mental retardation: The invention identifies Syngap1 dysfunctions as causative of mental retardation. Described are methods of detecting mental retardation and methods of detecting non-syndromic mental retardation (NSMR) in a human subject. Particular methods comprise sequencing a human subject's genomic DNA for comparison with a control sequence from an unaffected individual. Also described... Agent: Centre Hospitalier Universitaire Sainte-justine

20130065240 - Culture medium, method for culturing salmonella and e. coli and method for detecting salmonella and e. coli: In embodiments there are disclosed culture media, compositions for supplementing culture media, and methods for culturing biological samples. In embodiments the methods are methods for detecting bacteria and in embodiments the bacteria include Salmonella spp and in embodiments include E. coli spp. In embodiments the media and compositions comprise an... Agent: Foodchek Systems, Inc.

20130065239 - Diagnostic method for detecting acute kidney injury using heat shock protein 72 as a sensitive biomarker: The invention relates to a reliable, easy-to-implement non-invasive diagnostic method for detecting early acute kidney injury by measuring the concentration of a biomarker in urine samples, said biomarker being selected from heat shock proteins of the 70 KDa family. More specifically, the invention relates to the identification of heat shock... Agent:

20130065241 - Methods and compositions related to continuous flow thermal gradient pcr: Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR.... Agent: University Of Utah Research Foundation

20130065242 - Methods for diagnosing, prognosing and treating muscular dystrophy: Disclosed herein are methods for diagnosing, prognosing and treating muscular dystrophy. The disclosed methods can be used to diagnosis, prognosis or treat a subject with merosin-deficient congenital muscular dystrophy Type 1A (MDC1A), limb-girdle muscular dystrophy (LGMD), facioscapulohumeral (FHMD), Beckers muscular dystrophy (BMD) or Duchenne muscular dystrophy (DMD). Also disclosed are... Agent: The Board Of Regents Of The Nevada System Of Higher Education,

20130065243 - Method for producing induced pluripotent stem cells: s

20130065244 - Method for producing camp using chimeric olfactory receptor: A method for producing cAMP using a chimeric olfactory receptor. The method includes a step of preparing a reaction system comprising a first layer, a lipid bilayer membrane, and a second layer, and a step of supplying a chemical substance which stimulates the chimeric olfactory receptor to the first layer... Agent:

20130065245 - Device: Provided is an assay device and kit for detecting the presence or amount of an analyte of interest.... Agent: Alere Switzerland Gmbh

20130065252 - Compositions and methods for detecting autoantibodies: The invention provides compositions and methods for detecting thyroid hormone blocking immunoglobulin (TBI). The invention's methods are sensitive and specific for TBI, and may be used for the dual detection of both TBI and TSI. The invention's compositions and methods are useful for the diagnosis of diseases that are associated... Agent: Quidel Corporation

20130065253 - Detection system and uses therefor: A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent, comprising a second interacting group coupled to a second reporter component; iii) a third agent, comprising a third interacting group;... Agent: Dimerix Bioscience Pty Ltd.

20130065246 - Method for diagnosing melanocytic proliferations: The invention provides a method for diagnosing a melanocytic proliferation in a subject comprising staining a sample of lesional melanocytes with an antibody against soluble adenylyl cyclase (sAC) and interpreting the sAC staining pattern, which is associated with a diagnosis of a melanocytic proliferation. The sAC staining pattern, which is... Agent: Cornell University

20130065247 - Methods of diagnosing latent and active malignancies: Disclosed are procedures and methods for diagnosing latent and active cancers in a subject. The described methods include the use of sandwich ELISA assays containing antibodies specific for certain epitopes on the A-protein. This enables the assay to discriminate between the monomelic and homopolymeric forms of A-protein.... Agent: Ask Diagnostics, Inc.

20130065248 - Reagents and methods for sirtuin capture: The invention provides a method of preparing a sirtuin complex. The invention also provides a method of detecting a sirtuin in a sample comprising use of the aforesaid sirtuin complex.... Agent: Cornell University

20130065249 - Signal amplification for immunoassays by use of avidin-biotin linkages: In sandwich-type immunoassays that capture a protein analyte between a capture antibody, typically bound to a solid phase, and a detection antibody that is coupled to a reporter group, the number of reporter groups associated with each molecule of analyte is increased by a variety of methods that utilize avidin-biotin-type... Agent: Bio-rad Laboratories, Inc.

20130065250 - Kit and method for detecting porous dental hydroxyapatite: The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite, comprising a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite comprising detecting in or on a tooth... Agent:

20130065251 - Method and system for determination of molecular interaction parameters: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations... Agent: Ge Healthcare Bio-sciences Ab

20130065256 - Assay system: An assay apparatus comprising: i) an assay cartridge (52, 53) comprising at least one well (57-62) and a pipette (50) positionable in at least one said well; ii) a holder arranged to received said cartridge; iii) drive means operable to position said pipette in selected wells of said cartridge; iv)... Agent: Axis-shield As

20130065255 - Biomarker to measure drug efficacy in enteropathic disease: The diagnosis of a patient with an enteropathic disease or the response of a patient with an enteropathic disease to therapy, particularly a candidate therapy in a clinical trial setting, is assessed by detecting the ability of the patient to metabolize an orally administered CYP3A substrate. The CYP3A metabolism may... Agent:

20130065258 - Colorectal cancer marker galectin, method for analyzing galectin concentration in blood sample, and kit for detecting colorectal cancer marker galectin: The present invention provides a tumor screening marker that can be actually used in clinical practice to detect colorectal cancer, and a tumor progression marker that can complement CEA or CA19-9. Galectin-1 used as a tumor screening marker or a tumor progression marker for colorectal cancer. Galectin-3 used as a... Agent:

20130065257 - Enzyme-logic biosensing: Techniques, apparatus and systems are disclosed for implementing enzyme-logic based diagnosis that uses patterns of multiple markers and biochemical processing of the signal information for reliably identifying cardiac abnormalities and providing a final digital binary answer. In one aspect, a biochemical logic sensing system includes a network of enzyme-biocatalyzed logic... Agent:

20130065254 - Novel epigenetic mechanisms related to dna damage and aging: This invention pertains to markers of cellular senescence. In particular methylation of histone H1 (or isoforms thereof) at residue 172 and/or at residue 180 is a marker of cellular senescence. Antibodies specific to histone H1 (or isoforms thereof) methylated at residue 172 and/or at residue 180 are provided.... Agent: Buck Institute For Research On Aging

20130065259 - Methods for detection of botulinum neurotoxin: Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin. This assay is designed to capture a low number of toxin molecules and to measure their intrinsic protease activity via conversion of a fluorogenic or luminescent substrate.... Agent: City Of Hope

20130065260 - Compositions, methods and uses for simultaneous assay of thrombin and plasmin generation: Embodiments of the present invention report compositions and methods of analyzing thrombin and plasmin generation in a sample from a subject. In certain embodiments, the methods may comprise introducing at least one activator of coagulation and at least one activator of fibrinolysis to a sample and analyzing the sample for... Agent: The Regents Of The University Of Colorado, A Body Corporate

20130065261 - Modified glucose dehydrogenase gene: The present invention relates to a modified glucose dehydrogenase (GLD), comprising an amino acid sequence of a wild-type FAD-conjugated glucose dehydrogenase (GLD) represented by SEQ ID NO: 1 having a substitution of at least one amino acid residue selected from the group consisting of amino acid residues at positions 298,... Agent:

20130065262 - Phosphatase coupled glycosyltransferase assay: A kit for detecting or measuring glycosyltransferase activity including a first reagent comprising a phosphatase and a second reagent comprising a free phosphate detector, and method of detecting and measuring glycosyltransferase activity. A sugar donor, an acceptor substrate, a glycosyltransferase enzyme and a phosphatase are combined and the amount of... Agent: Research And Diagnostic Systems, Inc.

20130065263 - Fluorescent substrate for detection of enzymatic activity of nitrile-related enzyme: k

20130065264 - Method and medium for detecting shiga toxin-producing escherichia coli bacteria: The present invention relates to a method for specific and direct detection of Shiga toxin-producing Escherichia coli bacteria in a sample using a selective and differential isolation medium for Shiga toxin-producing Escherichia coli bacteria comprising at least one chromogenic agent and tellurite.... Agent:

20130065265 - Biomarker and method for determining an oxidative stress level: The present invention relates to a biomarker and a method for determining an oxidative stress level in a biological sample, which employs co-factor-dependent oxidative stress parameters, as well as a kit adapted for carrying out such a method. In one aspect the co-factor is tetrahydrobiopterin.... Agent:

20130065267 - Conjugates and methods for measuring chaperone-mediated autophagy: This disclosure relates to methods of detecting chaperone-mediated autophagy. In some embodiments, the disclosure relates to methods of measuring chaperone-mediated autophagy in living cells and in purified lysosomes. In some embodiments, the disclosure relates to methods of detecting, diagnosing, monitoring, and/or treating lysosomal diseases in a subject.... Agent: Emory University

20130065266 - Disease diagnosis method, marker screening method and marker using tof-sims: The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight... Agent: Korea Research Institute Of Standards And Science

20130065268 - Automatic device and method for inoculating a sample at different concentrations: An automatic device for inoculating a sample on a substrate with a dilution mechanism formed by a head that holds a stylus in cooperation with a first dilution tank and a second dilution tank to dilute an original sample in at least one sub-sample and for inoculating the sub-sample on... Agent: Interlab

20130065269 - Fine particle measuring apparatus: A fine particle measuring apparatus is provided. The fine particle measuring apparatus includes a detection unit configured to detect light emitted from a fine particle and a processing unit having a memory device storing instructions which when executed by the processing unit, cause the processing unit to calculate a corrected... Agent: Sony Corporation

20130065270 - Non-recombinant saccharomyces strains that grow on xylose: The present invention relates to methods for producing Saccharomyces strains that are capable of growth on xylose as a sole carbon source at a desired growth rate, (such as at least one generation per 48 hours), strains made by such methods, and Saccharomyces strains that grow at a growth rate... Agent: Microbiogen Pty Ltd.

20130065273 - Engineered e2 for increasing the content of free lys11-linked ubiquitin: The invention provides a chimeric E2 enzyme comprising a Ubc domain fused to a heterologous ubiquitin binding domain (UBD). The chimeric enzymes of the invention may be useful in producing elevated levels of free polyubiquitin.... Agent: Medical Research Council

20130065271 - Host cells and culture methods: Improved host cells and culture methods involving overexpression of MAN1C1 activity to improve protein production are provided.... Agent:

20130065272 - Synthesis of site specifically-linked ubiquitin: The invention relates to a method of modifying a specific lysine residue in a polypeptide comprising at least two lysine residues, said method comprising (a) providing a polypeptide comprising a target lysine residue protected by a first protecting group, and at least one further lysine residue; (b) treating the polypeptide... Agent: Medical Research Council

20130065274 - Recombinant prokaryotes and use thereof for production of o-glycosylated proteins: The present invention embraces a recombinant prokaryotic host cell containing nucleic acids encoding an eukaryotic UDP-GaINAc:UDP-GaINAc polypeptide transferase and expressing an UDP-GIcNAc C-4 epimerase and methods for using the same to produce an O-glycosylated protein.... Agent: Trustees Of Dartmouth College

20130065275 - Serum-free mammalian cell culture medium, and uses thereof: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or... Agent: Life Technologies Corporation

20130065276 - Compositions and methods of treating disease with fgfr fusion proteins: The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their... Agent: Five Prime Therapeutics, Inc.

20130065277 - Sequence dependent aggregation: Herein is reported a method for reducing the aggregation of an immunoglobulin in solution comprising the steps of i) comparing the amino acid sequence of the fourth framework region of the heavy chain of an antibody with a reference or germline sequence and determining whether one or more threonine residues... Agent:

20130065278 - Production of proteins and polypeptides: A method of producing a desired non-spidroin protein or polypeptide is comprising the steps of expressing in a suitable host a fusion protein, obtaining a mixture containing the fusion protein, and optionally isolating the fusion protein. The fusion protein is comprising at least one solubility-enhancing moiety which is derived from... Agent: Spiber Technologies Ab

20130065279 - Microorganisms for producing methacrylic acid and methacrylate esters and methods related thereto: The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or... Agent: Genomatica, Inc.

20130065281 - Method for synthesizing cdna: A method for synthesizing cDNA characterized by preparing a reaction solution that does not allow an endodeoxyribonuclease to show its activity, without thermal deactivation of the endodeoxyribonuclease or removal of the endodeoxyribonuclease, and carrying out a reverse transcription reaction, wherein the reaction solution contains a treated sample and a reverse... Agent: Takara Bio Inc.

20130065280 - Microfluidic apparatus and control method thereof: A microfluidic apparatus having an additional chamber containing material configured to prevent cross contamination between reaction chambers contained therein, and a control method thereof are provided. The microfluidic apparatus includes a sample chamber configured to accommodate a sample, a plurality of reaction chambers each configured to accommodate a reagent, a... Agent: Samsung Electronics Co., Ltd.

20130065282 - Fermentation process: Methods and systems for the production of one or more lipid products from a gaseous substrate using a two stage fermentation process are provided. The method comprises providing a gaseous substrate comprising CO2 and H2 to a primary bioreactor containing a culture or one or more microorganisms, and fermenting the... Agent: Lanzatech New Zealand Limited

20130065283 - Process for obtaining fatty acid alkyl esters from lipids in a membrane contactor: The present invention relates to a new process for obtaining fatty acid alkyl esters from fatty acid containing lipids, i.e. mono-, di- and triglycerides and phospholipids, in a membrane contactor.... Agent: Due Milj&#xd8 As

20130065285 - Chemoautotrophic conversion of carbon oxides in industrial waste to biomass and chemical products: Systems and methods for employing chemoautotrophic micro-organisms to capture carbon from industrial waste are provided. An exemplary system comprises an industrial source, such as a cement plant, and a bioreactor including the micro-organisms. The bioreactor is fed the waste stream from the source, which provides carbon to the micro-organisms, and... Agent:

20130065284 - Modified microorganism for highly efficient production of lactic acid: A modified microorganism for high efficient production of lactic acid, an expression vector for constructing the modified microorganism, and a method of producing a lactic acid using the same are disclosed. The modified microorganism may produce lactic acid at a high level under acid conditions.... Agent: Samsung Electronics Co., Ltd.

20130065286 - Processing biomass: Carbon-containing materials, such as biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) or coal are processed to produce useful products, such as fuels, carboxylic acids and equivalents thereof (e.g., esters and salts). For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials... Agent: Xyleco, Inc.

20130065287 - Chemical processing cell with nanostructured membranes: A chemical processing cell includes an upstream membrane and a downstream membrane. The upstream membrane generates a first reaction product. The downstream membrane converts the first reaction product to a second reaction product.... Agent: The University Of Kentucky Research Foundation

20130065288 - Production of xylitol from a mixture of hemicellulosic sugars: Materials and methods are described to produce xylitol from a mixture of hemicellulosic sugars by several routes. Examples include either as a direct co-product of a biorefinery or ethanol facility, or as a stand-alone product produced from an agricultural or forestry biomass feedstock including using, e.g. ethanol waste streams.... Agent: Zuchem Inc.

20130065289 - System for the treatment of biomass: A system for treating biomass for the production of ethanol is disclosed. A biorefinery for producing a fermentation product from biomass is disclosed. The biorefinery comprises a system for preparing the biomass into prepared biomass and a system for pre-treating the biomass into pre-treated biomass. The biorefinery comprises a separator,... Agent: Poet Research, Inc.

20130065290 - Combined dry and wet dual phase anaerobic process for biogas production: The present invention encompasses a self sustaining and combined dual biomethanation process to produce biogas and manure. The said biomethanation process comprises two or more different biogas reactors using mixed and/or multiple solid biomass as feed. The leachates generated from the solid digester are utilitzed by recirculating the leachates produced,... Agent: Kirloskar Integrated Technologies Limited

20130065291 - Coatings containing polymer modified enzyme for stable self-cleaning of organic stains: Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal... Agent: Toyota Motor Corporation

20130065292 - Method for increasing microbial catalase production: Disclosed are methods for increasing microbial catalase production. 1-10 g/L sodium hexametaphosphate was added to the culture medium between 30-40 hours of fermentation to inhibit proteinase activity and increase the production of catalase. This simple modification of fermentation procedure can result in up to 45% increase of the production of... Agent: Jiangnan University

20130065293 - Branched alpha-glucan, alpha-glucosyltransferase which forms the glucan, their preparation and uses: s

20130065294 - Cell-free synthesis of membrane bound polypeptides: Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of membrane-associated polypeptides.... Agent:

20130065295 - Compositions and methods relating to proteins requiring gamma-carboxylation: The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reductase and associated expression control sequences and a nucleic acid molecule encoding a γ-glutamyl... Agent: Medimmune Limited

20130065296 - Baculoviruses with enhanced virion production and a method for the production of baculoviruses: A method of co-expressing a portion of the VSV G protein gene or a truncated “stem” portion with GP64 and a retrovirus increases the titer of retroviral vectors. A truncated VSV G protein, preferably comprised of a small segment from the C-terminal portion of the ectodomain plus the transmembrane (TM)... Agent: Boyce Thompson Institute For Plant Research

20130065297 - Chromosomal insertion of gfp into bacteria for quality control: An isolated mutated green fluorescent protein (gfp) gene for chromosomal insertion into a bacterium, wherein the gene is capable of being expressed in bacteria and produce sufficient fluorescence under illumination from a UV lamp in a bacterial colony to be seen by the naked eye. A gene cassette for inserting... Agent: Btf Pty Ltd.

20130065298 - Sirna-mediated gene silencing: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.... Agent: University Of Iowa Research Foundation

20130065299 - Actriib-fc polynucleotides, polypeptides, and compositions: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuron. The present invention also provides methods of screening compounds that modulate activity of an ActRII protein and/or an ActRII ligand. The compositions and... Agent: Acceleron Pharma, Inc.

20130065300 - Dry powder cells and cell culture reagents and methods of production thereof: The present invention relates generally to nutritive medium, medium supplement, media subgroup and buffer formulations. Specifically, powdered nutritive medium, supplement, subgroup formulations, cell culture media comprising all of the necessary nutritive factors for in vitro cell cultivation, buffer formulations that produce particular ionic and pH conditions upon reconstitution with a... Agent: Life Technologies Corporation

20130065301 - Systems and methods for cryopreservation of cells: An auto-nucleating device includes a tube containing a crystalline cholesterol matrix. The ends of the tube are closed by a membrane impermeable to the cholesterol but permeable to liquids contained in a cryopreservation vessel. The auto-nucleating device provides a site for ice nucleation during freezing of the liquid within the... Agent:

20130065302 - Umbilical cord lining stem cells and methods and material for isolating and culturing same: Human umbilical cord lining stem cells that are capable of differentiating into cells of the mesodermal lineage and ectodermal lineage are described, as well as methods of isolating, expanding, culturing, and cryopreserving such cells.... Agent: Davinci Biosciences LLC

20130065304 - Differentiation process of mesenchymal stem cells and therapeutic use thereof: Process for inducing differentiation of mesenchymal stamina cells into neuroblasts and/or neurons that envisions the use of a differentiation solution consisting of retinoic acid and ethanol.... Agent:

20130065303 - Method for inducing spheroid formation of adipose-derived stem cells and trans-differentiation into neural lineage: The present invention relates to a basal medium for spheroid formation of adipose-derived stem cells, comprising a substrate; and a chitosan film faulted on a surface of the substrate, wherein the chitosan film comprises chitosan with 60-90% degree of deacetylation, and the chitosan film has a surface roughness defined by... Agent:

20130065305 - Mammary artery derived cells and methods of use in tissue repair and regeneration: An isolated mammalian internal mammary artery-derived cell is disclosed. Furthermore, methods of isolating the mammalian internal mammary artery-derived cell are disclosed. The cell is useful in tissue engineering technologies, specifically in vascular tissue engineering.... Agent: Advanced Technologies And Regenerative Medicine, LLC

20130065306 - Method for maturing and synchronizing conifer somatic embryos: A method for the culture of somatic plant embryos comprising contacting said embryos with a culture medium containing a plasmolytic or near plasmolytic concentration of a sugar alcohol or a combination of sugar alcohols; and culturing said embryos in said culture medium for a time period suitable for the desired... Agent:

20130065307 - Use of rna interference for the creation of lineage specific es and other undifferentiated cells and production of differentiated cells in vitro by co-culture: Methods for making human ES cells and human differentiated cells and tissues for transplantation are described, whereby the cells and tissues are created following somatic cell nuclear transfer. The nuclear transfer donor is genetically modified prior to nuclear transfer such that cells of at least one developmental lineage are de-differentiated,... Agent:

20130065308 - Cationic lipids: t

20130065309 - Preparation of negative-stranded rna viruses by electroporation: The present invention encompasses methods of preparing non-segmented negative-stranded RNA viruses from cells utilizing electroporation.... Agent: Medimmune, LLC

20130065310 - Use of endogenous promoters to express heterologous proteins: The present invention provides methods for using endogenous transcriptional control systems to regulate the expression of heterologous protein(s). In particular, targeted genome editing is used to integrate a sequence encoding the heterologous protein(s) in-frame with an endogenous coding sequence such that the expression of the heterologous and endogenous sequences is... Agent: Sigma-aldrich Co., LLC

20130065311 - Method of nuclear reprogramming: A method of producing an induced pluripotent stem cell includes introducing into a somatic cell one or more non-viral expression vectors. The vectors include one or more of an Oct family gene, a Klf family gene, a Sox family gene, a Myc family gene, a Lin family gene, and Nanog... Agent: Kyoto University

20130065314 - Algal transformation systems, compositions and methods: One aspect of the invention relates to a method for introducing a cargo molecule into an algal cell, the method comprising preparing a composition comprising the cargo molecule and a cell penetrating peptide (CPP) and exposing the algal cell to the composition. The method may also comprise treating the algal... Agent: Phytocentric Biotech Inc.

20130065312 - Method and composition for generating programmed cell death resistant algal cells: The present invention provides transgenic algal cells resistant to programmed cell death (PCD) and methods and compositions useful in generating such cells. Specifically, the invention utilizes expression of one or more mammalian anti-apoptotic genes in algal cells to promote resistance to PCD, which is useful for stress tolerance and increased... Agent: The Johns Hopkins University

20130065313 - Molecular biology tools for algal engineering: The present invention provides compositions and methods for the genetic manipulation of Algal cells. The compositions and methods allow enhanced transfer of genetic material into Algal cells and the cloning and selection of genetically modified cells. Expression of proteins encoded by the genetic material will be enhanced by the methods... Agent: Life Technologies Corporation

20130059285 - Aqueous solution for the preservation of tissues and organs: It is provided an improved aqueous solution for the preservation of tissues and organs comprising carvedilol, tacrolimus, and trimetazidine. A synergistic effect is observed for this preservation solution which is particularly effective in marginal organs, such as steatotic livers.... Agent: Institut D'investigacions Biom&#xc9 Diques August Pi I Sunyer

20130059286 - Cryopreservation of umbilical cord tissue for cord tissue-derived stem cells: A method of preserving an umbilical cord is disclosed. The method comprises obtaining a segment of an umbilical cord; mincing the segment of the umbilical cord into cord tissue pieces; admixing the cord tissue pieces with a cryogenic composition comprising a cryoprotectant and a protein to form a mixture; shaking... Agent: Healthbanks Biotech Co., Ltd.

20130059288 - Method for isolating target cells: The present invention relates to a method for the enrichment and/or isolation of target cells in a sample, which sample comprises red blood cells and/or platelets, comprising (a) filtering the sample through a filter element having a pore or mesh size of between 0.5 and 5 μm, (b) contacting the... Agent: Universit&#xc4 Tsklinikum Hamburg-eppendorf

20130059287 - Prolonging survival of platelets using cmp-sialic acid, udp-galactose or both: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to... Agent:

20130059289 - Adeno-associated virus serotype i nucleic acid sequences, vectors and host cells containing same: The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors.... Agent: The Trustees Of The University Of Pennsylvania

20130059291 - Compositions and methods for identifying dengue virus: The invention generally relates to compositions and methods for identifying dengue virus. In certain embodiments, the invention provides methods for identifying a dengue virus serotype that involve obtaining a sample comprising at least one dengue virus protein; digesting the protein to produce peptides; ionizing the peptides; detecting a parent and... Agent: Purdue Research Foundation

20130059290 - Detection of nucleic acids in crude matrices: A method includes contacting a crude matrix with components of an isothermal nucleic acid amplification reaction for a target nucleic acid species, thereby providing a mixture; incubating the mixture under conditions sufficient for the isothermal nucleic acid amplification reaction to proceed, thereby providing a product; and determining whether an indicator... Agent: Alere San Diego, Inc.

20130059294 - Identification of polymorphic hepatitis b viruses and kras oncogene mutations and clinical use: The present application provides a method of monitoring patients of chronic hepatitis B virus (HBV) infection undergoing nucleoside/nucleotide analogue antiviral treatment for treatment efficacy and for risk of drug-resistance, by simultaneous determination of quantities of viral DNA and identification of mutant viruses responsible for drug-resistance. This invention also provides methods... Agent:

20130059293 - Magnetic resonance system and method to detect and confirm analytes: A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the... Agent: Menon International, Inc.

20130059292 - Method of detecting a target using aptamer-mediated protein precipitation assay: The present invention relates to a method and detection kit for determining a presence of one or more proteins using aptamer-mediated pull-down assays. Specifically, a reproducible a protein precipitation (Co-AP/AP) method is provided to identify physiologically relevant protein-protein interactions by using target protein-specific aptamers, and to confirm its superior performance... Agent: Aptamer Sciences Inc.

20130059298 - Composition and method for treatment of tumors: The present invention relates to a composition which is useful in the treatment of a tumor, a method for making such a composition, and a method for using such a composition. The invention relates also to a method for assaying for inhibitors of the activity of Core 1 protein and/or... Agent: Sanofi

20130059296 - Compositions and methods for high fidelity assembly of nucleic acids: Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end double-stranded nucleic acid fragments having a restriction enzyme recognition sequence at both ends thereof; (2) producing via enzymatic digestion a plurality of... Agent: Gen9, Inc.

20130059295 - Host cells and methods for producing fatty acid: The present invention provides for a genetically modified host cell capable of producing fatty acid comprising an increased expression of FadR, or a functional variant thereof. The host cell under environmental conditions wherein fatty acid is produced expresses an increased amount of FadR when compared to an unmodified host cell.... Agent: The Regents Of The University Of California

20130059297 - Method for isolating renal stem/progenitor cells, renal stem/progenitor cells and therapeutic agent for renal disease: It is intended to provide a method for noninvasively isolating human renal stem/progenitor cells, an isolated renal stem/progenitor cells, a therapeutic agent for renal disease, mouse mesenchymal cells which can be used for isolating human renal stem/progenitor cells and a culture supernatant of the same. Renal stem/progenitor cells are isolated... Agent: Bio Link, Incorporated

20130059299 - Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefore: The present invention provides novel mitochondrial fusion transcripts, the parent mutated mtDNA molecules, and the resulting translation products (proteins) for predicting, diagnosing and/or monitoring cancer. Hybridization probes complementary thereto for use in the methods of the invention are also provided.... Agent: Mitomics Inc.

20130059301 - Asxl1 as a new diagnostic marker of myeloid neoplasms: A method for diagnosing a myeloid cancer in a subject, includes the step of analyzing a biological sample from the subject by determining the presence or the absence of a mutation in the ASXL1 (additional sex combs like 1) gene coding for the polypeptide having the sequence SEQ ID N°2.... Agent: Ipsogen

20130059303 - Cdkn2a as a prognostic marker in bladder cancer: The present invention provides methods for predicting clinical outcome and for providing information for determining follow-up strategy of a subject affected with a non-muscle invasive bladder cancer, as well as a method for selecting a subject affected with a non-muscle invasive bladder cancer for an anti-tumoral therapy. The present invention... Agent:

20130059300 - Insect resistant cotton plants and methods for identifying same: The invention provides specific transgenic cotton plants, plant material and seeds, characterized in that these products harbor a specific transformation event at a specific location in the cotton genome. Tools are also provided which allow rapid and unequivocal identification of the event in biological samples.... Agent: Bayer Cropscience, N.v.

20130059307 - Methods and compositions for detecting fungi and mycotoxins: The invention relates to a method of identifying a specific fungal species in patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the fungal species from the patient tissue or body fluid, amplifying the DNA, hybridizing a probe to the DNA to specifically... Agent: Medical Service Consultation International, LLC

20130059302 - Nucleic acid detection apparatus, method and computer readable recording medium: A light reception section receives fluorescence emitted according to the amount of target nucleic acid that has been amplified by PCR due to a light source illuminating excitation light onto a reaction liquid. Electrical signals from the light reception section whose level depends on the received fluorescence intensity are amplified... Agent: Arkray, Inc.

20130059308 - Polymer microfilters and methods of manufacturing the same: A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the... Agent:

20130059306 - Primer and probe for detecting chlamydia trachomatis, and method for detecting chlamydia trachomatis using same: The present invention relates to an oligonucleotide which is designed on the basis of a nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2 and hybridizes with the endogenous plasmid gene of Chlamydia trachomatis, oligonucleotide primer and probe for detecting Chlamydia trachomatis, the detection method of... Agent:

20130059304 - Translocation and mutant ros kinase in human non-small cell lung carcinoma: In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of Sodium-dependent Phosphate Transporter Isoform NaPi-3b protein (SLC34A2) with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The SLC34A2-ROS fusion... Agent: Cell Signaling Technology, Inc.

20130059305 - Translocation and mutant ros kinase in human non-small cell lung carcinoma: In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of Sodium-dependent Phosphate Transporter Isoform NaPi-3b protein (SLC34A2) with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The SLC34A2-ROS fusion... Agent: Cell Signaling Technology, Inc.

20130059310 - Compositions and methods for intramolecular nucleic acid rearrangement: Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving... Agent: Population Genetics Technologies Ltd

20130059309 - Dopaminergic neurons derived from induced pluripotent stem cells and method of making same: Provided are compositions and methods that relate to cultured neurons. The cultured neurons can either have or not have genetic mutations that are characteristic of Parkinson's disease (PD). The cultured neurons are generated from induced pluripotent stem cells made from human fibroblasts that are obtained from individuals with and without... Agent:

20130059311 - Method for the identification of memory modulating compounds by assessing kibra expression: Provided are cell based methods to identify memory modulating compounds based on the assessment of KIBRA expression. These methods are also suitable to uncover memory related pathways. The methods comprise the contacting of test compounds with cultured cells and the subsequent assessment of modulation of the KIBRA expression within the... Agent: Sygnis Bioscience Gmbh & Co Kg

20130059312 - Methods of using chimeric receptors to identify autoimmune disease: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much... Agent: Quidel Corporation

20130059313 - Analyte quantification using flow induced dispersion analysis: A method for quantitative characterization of non-covalent interactions and analyte quantification in nanoliter samples is described. The procedure is based on Flow Induced Dispersion Analysis (FIDA), of which the only system requirements is a narrow tube, capillary or channel equipped with a detector. The technique can be implemented using standard... Agent: Fida-tech Aps

20130059317 - Binding partners for the thyrotropin receptor and uses thereof: A binding partner for the TSH receptor, which binding partner comprises, or is derived from, a human monoclonal or recombinant antibody, or one or more fragments thereof, reactive with the TSH receptor, uses thereof, methods of diagnosis and therapy employing the same, and anti-idiotypic antibodies thereto.... Agent: Rsr Limited

20130059315 - Alpha-amylase mutants: b

20130059314 - Fret-based method for the determination of protein phosphatase and kinase activity: This disclosure relates to methods of determining activities of protein phosphatases and kinases. The disclosure further relates to methods of clinical monitoring of calcineurin activity and immunosuppression in patients and which may be used to predict transplant acceptance in patients.... Agent: Emory University

20130059316 - Plasmonic electricity: The present invention relates to detection systems and methods that detect fluorescence, luminescence, chemiluminescence or phosphorescence signatures in the form of an electrical signal conducted and emitted from metallic containing surfaces. Thus, the present invention provides for detecting fluorescence digitally and directly without the need for expensive detectors.... Agent:

20130059318 - Anti-iga1 antibody: An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is... Agent: Kyowa Hakko Kirin Co., Ltd.

20130059319 - Method and a device for detecting, classifying, and identifying particles, aerosols, and/or vapors in the air: A method and device are disclosed for continuously detecting, classifying and identifying toxic particles, aerosols and/or vapor in an air sample, in near real time by directing an air sample containing an optional target analyte, in the form of particles, aerosols and/or vapors, enzyme(s), and enzyme substrate(s), to a surface... Agent:

20130059320 - Selective growth media for campylobacter bacteria and plating media with said growth media: A selective growth media for Campylobacter bacteria comprising nutrients, growth inhibitors for organisms other than Campylobacter including bile salts, Irgasan DP 300, sodium cefsulodin hydrate, cycloheximide and sodium cefoperazone, and one or more ingredients for absorbing oxygen. Also, selective plating media for Campylobacter bacteria comprising said growth media, a thickening... Agent:

20130059321 - Labeling of proteins with the fluorophore 7-amino-4-methylcoumarin (amc) generated novel proteolytic substrates: A method of measuring the degradation of intact proteins includes a step of providing a protein substrate having one or more free or exposed carboxyl groups and then reductively attaching 7-amino-4-methylcoumarin (AMC) to the protein substrate with a reducing agent. The protein substrate is contacted in a test solution with... Agent: University Of Southern California

20130059322 - Cell culture and invasion assay method and system: Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.... Agent: Cellasic, Inc.

20130059323 - Detection of overtraining syndrome in an individual: The onset of or the existence of overtraining syndrome in an individual is detected by a method which comprises a) contacting leucocytes in, or obtained from, a blood sample provided by the individual with a luminescence reagent which emits light on reaction with an oxidant; b) adding an activator to... Agent:

20130059325 - Isolated populations of adult renal cells and methods of isolating and using same: A method of generating a nephrospheroid is disclosed. The method comprises culturing human adult kidney cells in a culture medium under non-adherent conditions. Uses thereof and other renal cell populations are also disclosed.... Agent: Tel Hashomer Medical Research Infratructure And Services Ltd.

20130059324 - Systems and methods for mechanically strained cell culture: A method for in vitro drug screening can include: providing one or more cells in vitro; introducing a chemical to the one or more cells; introducing a mechanical strain to the one or more cells in the presence of the chemical; and determining whether or not the chemical has bioactivity... Agent: The University Of Kansas

20130059326 - Membrane transfer method and tool: A method for transferring a filter membrane (130) bearing a retentate to a reagent pad (310), in which the membrane is mounted in a support frame (120) having a shoulder (121) and a skirt (122) projecting from the shoulder, the pad being mounted on a cassette (300) of complementary form... Agent: Emd Millipore Corporation

20130059327 - Automatic toxicological fluid sample preparation module, automatic analysis system and method for use thereof: This present invention relates to an automatic toxicological fluid sample preparation module and method for use thereof, for automatically preparing a fluid sample for the detection and measurement of toxics and/or toxicological effects. The invention further relates to an automatic analysis system. The automatic toxicological fluid sample preparation module comprising:... Agent: Dutch Water Technologies B.v.

20130059328 - Production of enteritis evoking causal factor by highly pathogenic oral bacteria and high sensitivity detection method therefor: Disclosed is the construction of a system capable of quickly and easily identifying patients having a risk for worsening inflammatory digestive tract disease by identifying a causal factor for the worsening of the inflammatory digestive tract disease. Specifically disclosed is a method for detecting oral bacteria that cause worsening of... Agent: Osaka University

20130059329 - Apparatus and method for distributing liquid samples in small volumes: Apparatus for dispensing liquids in small sample volumes, comprising a preformed rigid duct of impermeable material, with one inlet and one or more outlets, characterized in that the duct dimensions vary along it, forming communicating ducts, bifurcations and reservoirs; and a process for its manufacture.... Agent:

20130059330 - Fixing solution for biological cells: p

20130059331 - Cell suitable for fermentation of a mixed sugar composition: The present invention relates to a cell suitable for production of one or more fermentation product from a sugar composition comprising glucose, galactose, arabinose and xylose, wherein the cell comprises two to fifteen copies of one or more xylose isomerase gene or two to fifteen copies of one or more... Agent: DsmIPAssets B.v.

20130059332 - Method for the production of an aqueous glucose solution: The present invention relates to a process for the production of an aqueous glucose solution from maize or maize kernels. The invention also relates to a glucose solution obtainable by this process, and to its use for the production of organic compounds. The process according to the invention comprises: a)... Agent: Basf Se

20130059333 - Hematopoietic cell selectin ligand polypeptides and methods of use thereof: The invention feature methods and compositions for treating inflammatory disorders, hematopoietic disorders and non-hematopoietic disorders (e.g., non-hematopoietic cancers) and for isolating cells (e.g., stem cells) in a mammal.... Agent:

20130059336 - Hydrophobic interaction chromatography method: Herein is reported a method for purifying a polypeptide comprising a histidine-tag comprising the steps of i) applying a solution comprising the polypeptide with a histidine-tag to a hydrophobic interaction chromatography material, and ii) recovering the polypeptide comprising a histidine-tag with a solution comprising imidazole or an imidazole-derivative and thereby... Agent: Hoffmann-la Roche Inc.

20130059334 - Production of recombinant selenoprotein mutants with enhanced catalytic activity: The present invention generally relates to the production of industrially relevant quantities of selenoprotein enzymes in eukaryotic cell cultures. More specifically, the present invention generally relates to the production of such enzymes wherein one or more catalytic cysteine or serine residues are mutagenically replaced by selenocysteine.... Agent: The Ohio State University Research Foundation

20130059335 - Use of a genetically modified cell line expressing functional asialoglycoprotein receptor in the production of sialylated glycoproteins: The present invention is directed to the use of a cell line in the production of sialylated glycoprotein, wherein said cell line expresses functional ASGPR protein as well as to a method for the production of sialylated glycoproteins, characterized in that such a cell line is used.... Agent: Charite-universitatsmedizin Berlin

20130059337 - Therapeutic uses of humanized antibodies against alpha-4 integrin: The invention provides method of treatment using humanized immunoglobulins that specially bind to alpha-4 integrin. The methods are useful for treatment of asthma, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, transplant rejection, graft versus host disease, tumor metastasis, nephritis, atopic dermatitis, psoriasis, myocardial ischemia, and acute leukocyte mediated... Agent: Elan Pharmaceuticals, Inc.

20130059338 - Artificial entropic bristle domain sequences and their use in recombinant protein production: Compositions and methods for recombinant protein production and, more particularly, fusion polypeptides, polynucleotides encoding fusion polypeptides, expression vectors, kits, and related methods for recombinant protein production.... Agent: Molecular Kinetics Incorporated

20130059339 - Apparatus and methods for cell culture: A bioreactor (1) for the culture of cells (C) comprising a stack of carriers (7) for cell (C) adherence and liquid medium (M) distribution. The carriers (7) are stacked so as to define levels (6) between adjacent carriers (7) for the flow of the liquid medium (M). Adjacent levels (6)... Agent:

20130059340 - Biocatalytic production of glycosides: The present invention relates to the biocatalytic production of glycosides. In particular, the invention discloses a method to produce alkylcellobiosides, arylcellobiosides, cellobiolipids, cellotriolipids, glucosophorolipids and cellobiosesophorolipids via the usage of a cellodextrin phosphorylase (CDP) derived from Clostridium stercorarium (CsCDP). The method of the present invention is feasible for use in... Agent: Universiteit Gent

20130059341 - Method for producing glucuronic acid conjugate using saccharomyces cerevisiae: Provided is a new method for producing a glucuronide, having excellent productivity and being replaceable with a method using Saccharomyces pombe, and to provide a new means used in this production method. Disclosed are: a transformed Saccharomyces cerevisiae wherein a gene coding for a UDP-glucose dehydrogenase and a gene coding... Agent: Toyama Prefecture

20130059342 - Compositions and methods for use in recombinational cloning of nucelic acids: The present invention relates to compositions and methods for use in recombinational cloning of nucleic acid molecules. In particular, the invention relates to nucleic acid molecules encoding one or more recombination sites or portions thereof, to nucleic acid molecules comprising one or more of these recombination site nucleotide sequences and... Agent: Life Technologies Corporation

20130059344 - Transcription terminator sequences: The present invention provides new transcription termination signal sequences, especially a polynucleotide comprising at least two consecutive transcription termination signals, characterized in that said consecutive transcription termination signals comprise at least a first and a second transcription termination signal that are at most 1000 nucleotides apart, and at least one... Agent: Sandoz Ag

20130059343 - Nucleotide derivatives: The present invention provides compounds and methods for attaching fluorescent labels to biological molecules such as nucleotides. The compounds and methods are useful for biological assays including DNA modification reactions.... Agent: Li-cor, Inc.

20130059346 - Conversion system for biomass: The efficient production of ethanol from low-cost biomass (e.g., corn, sugar beets, sugar cane, switchgrass and/or paper) has become increasingly important in making ethanol competitive with gasoline and decreasing the United States' dependence on foreign oil. For example, to reduce the cost of transporting biomass to ethanol production facilities, mobile... Agent: Xyleco, Inc.

20130059345 - Manufacturing method for sugar solution and device for same: A method of hydrolysis of cellulose uses a filamentous fungus-derived cellulase as a carbohydrase and includes adding the carbohydrase to cellulose to perform primary hydrolysis and then subjecting the primary hydrolysate to solid-liquid separation into a primary sugar liquid and solids; adding water to the solids and performing secondary hydrolysis,... Agent: Toray Industries, Inc.

20130059347 - Saccharified-solution manufacturing method and saccharified-solution manufacturing device used in said method: A substrate and ammonia water are mixed at a predetermined mass ratio to yield a substrate mixture, the mixture is retained at a predetermined temperature for a predetermined time period for dissociating lignin from the substrate or swelling the substrate to yield a pretreated ammonia-containing product for saccharification. To a... Agent: Honda Motor Co., Ltd.

20130059349 - Method for producing acrylamide using microbial catalyst: The present invention provides a more efficient method for producing acrylamide from acrylonitrile by the action of a microbially-derived enzyme, nitrile hydratase. More specifically, the present invention provides a method for producing acrylamide from acrylonitrile using a biocatalyst having nitrile hydratase, which comprises the step of keeping acrylonitrile while cooling... Agent: Dia-nitrix Co., Ltd.

20130059348 - Novel amidase, gene for the same, vector, transformant, and method for production of optically active carboxylic acid amide and optically active carboxylic acid by using any one of those items: The present invention has its object to provide a novel polypeptide having amidase activity to selectively hydrolyze S-enantiomer in racemic nipecotamide, a DNA encoding the polypeptide, a vector containing the DNA, a transformant transformed with the vector, and a method for producing an optically active carboxylic acid amide and an... Agent: Kaneka Corporation

20130059350 - Constructs and methods for increasing yield of fatty alcohols in cyanobacteria: A construct containing a gene operably linked to a promoter having activity in cyanobacteria, and vector and cyanobacterium comprising such construct for increasing the yield of fatty alcohols in cyanobacterium is provided.... Agent: Shell Oil Company

20130059351 - Thioesterase and a method of producing fatty acids or lipids using the thioesterase: A thioesterase comprising an amino acid sequence set forth in SEQ ID NO: 1, a thioesterase gene encoding the thioesterase, a transformant comprising the gene, and a method of producing fatty acids or lipids using the transformant.... Agent:

20130059352 - Alcohol production process: The invention relates generally to methods for improving the microbial fermentation of gaseous substrates to produce one or more products. The invention relates to the capture of one or more components of a gaseous stream in a liquid. The invention relates to the deoxygenation of a liquid by contacting the... Agent: Lanzatech New Zealand Limited

20130059353 - Recombinant microorganisms for production c4-dicarboxylic acids: Provided herein are host cells comprising carbonic anhydrase activity, wherein the cells are capable of producing C4-dicarboxylic acid. Also provided are methods of producing C4-dicarboxylic acid comprising (a) cultivating the host cells having carbonic anhydrase activity in a medium under suitable conditions to produce C4-dicarboxylic acid; and (b) recovering the... Agent: Novozymes, Inc.

20130059354 - Alkanol: The present invention provides a process for the production of an alkanol (e.g. butanol) comprising converting a carbon source such as a biomass into a carboxylic acid or a derivative thereof using a microorganism, and electrochemically reducing said acid to said alkanol, as well as an apparatus for carrying out... Agent: Statoil Petroleum As

20130059355 - Thermophilic micro-organisms for ethanol production: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.... Agent: Tmo Renewables Limited

20130059356 - Ethanol production from mannitol using yeast: This invention provides a method for producing ethanol from mannitol using yeast and a yeast strain that produces ethanol from mannitol. The method for producing ethanol from mannitol comprises culturing yeast strains capable of mannitol assimilation and ethanol production from mannitol in a medium containing mannitol.... Agent: Maruha Nichiro Holdings, Inc.

20130059358 - In-situ electrical stimulation of bioconversion of carbon-bearing formations: Methods of stimulating microbial consortia, such as microbial consortia in a geological formation, such as comprising methanogens and other bacteria, for producing methane and other fuels or fuel precursors from coal or other carbonaceous materials, are disclosed along with methods for increasing bioconversion of carbonaceous materials, such as coal, into... Agent: Ciris Energy, Inc.

20130059357 - Process for producing biogas: Process for the production of a biogas containing methane from an organic matter amenable to anaerobic digestion comprising feeding an anaerobic digester with the organic matter, said anaerobic digester containing a digestion medium comprising microorganisms capable of digesting said organic matter, wherein the total inorganic carbon concentration of the digestion... Agent: Solvay Sa

20130059360 - Polymer-based compositions and conjugates of antimicrobial agents: Provided herein are water-soluble polymer conjugates and polymer-based compositions of antimicrobial agents. Also provided are methods for synthesizing and administering such conjugates and compositions.... Agent: Nektar Therapeutics

20130059359 - Protein nanorings: The invention provides protein nanorings.... Agent: University Of Minnesota

20130059361 - Compositions and methods for effecting the levels of high density lipoprotein (hdl) cholesterol and apolipoprotein ai, very low density lipoprotein (vldl) cholesterol and low density lipoprotein (ldl) cholesterol: Compositions and methods for raising the level of HDL cholesterol and apolipoprotein AI in a patient and for lowering the levels of VLDL cholesterol and LDL cholesterol in a patient, including compositions and methods which effect the expression of a gene, LIPG, which encodes a lipase enzyme that is a... Agent:

20130059362 - Biosensors comprising protein-binding domains and fluorescent proteins: The present invention provides compositions and methods for monitoring cellular signal transduction events. In particular, signal transduction events may be monitored by the use of biosensors comprising protein-binding domains, which bind signal-transduction proteins, and fluorescent proteins. Provided herein, therefore, methods for detecting activation of signal transduction proteins or screening for... Agent: Sigma-aldrich Co., LLC

20130059363 - Isolated nucleic acids for producing high viscosity diutan gums and methods: The production of a diutan polysaccharide exhibiting increased viscosity properties as compared with previously produced polysaccharide of the same type of repeating units. Such an improved diutan polysaccharide is produced through the generation of a derivative of Sphingomonas sp. ATCC 53159 that harbors a multicopy broad host-range plasmid into which... Agent: Cp Kelco U.s., Inc.

20130059364 - Cultivation of dispersed mycobacteria: The present invention relates to a culture medium for disperse mycobacteria comprising at least one detergent and an antifoam agent, whereby said antifoam agent is a member of the silicone family. In addition, the invention provides for methods for the activation of dipressed mycobacteria, for obtaining a standardized mycobyterial culture... Agent: Novartis Vaccines And Diagnostics Gmbh

20130059365 - Target gas capture: Capturing a target gas includes contacting a gas mixture including a target species with an aqueous solution including a buffer species, and transferring some of the target species from the gas mixture to the aqueous solution. The target species forms a dissolved target species in the aqueous solution, and the... Agent: Carbon Engineering Limited Partnership

20130059366 - Integrated droplet actuator for gel; electrophoresis and molecular analysis: The invention is directed to a droplet actuator device and methods for integrating gel electrophoresis analysis with pre or post-analytical sample handling as well as other molecular analysis processes. Using digital microfluidics technology, the droplet actuator device and methods of the invention provide the ability to perform gel electrophoresis and... Agent: Advanced Liquid Logic, Inc.

20130059367 - Ultrasensitive biosensors: The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are... Agent: University Of Hawaii

20130059369 - Microalgae cultivation module: A microalgae cultivation module for carbon reduction and biomass production is provided, which includes a first photobioreactor set, a second photobioreactor set, a gas switching device and a control unit. The gas switching device is communicated to the first and the second photobioreactor sets. The control unit is coupled to... Agent: National Chiao Tung University

20130059368 - System for culturing and recovering micro algae: A system for culturing and recovering micro algae comprises a photo-bioreactor, a floatation separator, a centrifugal separator, and a micro bubble generator. The photo-bioreactor unit is configured to culture micro algae by a photochemical reaction to produce a micro algae precipitate. The precipitated micro algae is separated by the floatation... Agent: Hyundai Motor Company

20130059370 - Recovery of higher alcohols from dilute aqueous solutions: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation... Agent: Gevo, Inc.

20130059371 - Device, system and process for modification or concentration of cell-depleted fluid: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at... Agent:

20130059372 - Sample processing units, systems, and related methods: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing... Agent: Ibis Biosciences, Inc.

20130059373 - Endometrial polyp stem cell: An endometrial polyp stem cell is disclosed in the present invention. The endometrial polyp stem cell is isolated from an endometrial polyp tissue, expresses vimentin, CD13, CD29, CD44, and CD90, and has no expression of CD1q, CD3, CD34, and CD45.... Agent: Buddhist Tzu Chi General Hospital

20130059375 - Method for preparing es cells: The present invention provides a method of producing a mammalian ES cell, including cultivating a mammalian inner cell mass in a medium containing adrenocorticotropic hormone, an FGF receptor inhibitor, an MEK activation inhibitor and a GSK3 inhibitor, and isolating a mammalian ES cell from the culture.... Agent: Riken

20130059374 - Novel therapeutical tools and methods for treating blindness: The present inventions relates to the use of an isolated nucleic acid molecule comprising a nucleotide sequence coding for a hyperpolarizing light-gated ion channel or pump gene from an archeon or for a light-active fragment of said gene, or the nucleotide sequence complementary to said nucleotide sequence, for treating or... Agent: Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Resear

20130059376 - Culture vessel and method of growing cells in culture vessel: A culture vessel and a method of growing cells in a culture vessel. The culture vessel includes a container and a plurality of agitators. The container receives a medium and cells. The plurality of agitators is positioned to contact the medium when received in the container and configured to promote... Agent: Global Cell Solutions, LLC

20130059377 - Stem cell defined media for xeno-free and feeder free conditions and uses thereof: The invention provides a defined low protein culture medium for maintaining cells in an undifferentiated state, the medium comprising: a basal medium, an organic acid from the tricarboxylic acid cycle, nonessential amino acids, a combination of growth factors selected from the group consisting of FGF-2 protein, an IGF-1 protein or... Agent:

20130059378 - Human epidermis-derived mesenchymal stem cell-like pluripotent cells and preparation method thereof: The invention discloses a cell culture medium, human epidermis-derived mesenchymal stem cell-like pluripotent cells and a preparation method thereof. The culture medium is formed by adding fetal bovine serum, hbFGF, hSCF, non-essential amino acids, L-glutamine and gentamicin into a DMEM culture medium with the glucose content of 0.5-5 g/L, wherein... Agent:

20130059379 - Method for the generation of a cik cell and nk cell population: The present invention is directed a method for the generation and/or expansion of CIK cell and/or NK cells by culturing peripheral blood cells in the presents of cytokines. The cytokines used in the method comprise interleukin 15 (IL-15) and interleukin 7 (IL-7), possibly in combination with further cytokines like interleukin... Agent:

20130059380 - Preservation solutions for biologics and methods related thereto: The present invention provides compositions (i.e., preservation solutions) for preserving biologies comprising at least one membrane penetrable sugar, at least one membrane impenetrable sugar, at least one anti-microbial agent, at least one anti-oxidant, adenosine, albumin, a salt, a buffer, and a chelating agent, and to methods of using such preservation... Agent: Hememics Biotechnologies, Inc.

20130059381 - Solution for non-programmed cell cryopreservation: The invention provides a solution for non-programmed cell cryopreservation, which comprises 1.0-28 w/v % of cell membrane protectant, 1.0-18 w/v % of permeable intracellular protectant, 3.0-28 w/v % of cell sedimentation stabilizer, and the balance of solvent. The cell cryopreservation solution provided by the invention is good for protecting cells.... Agent:

20130059382 - Biomedical materials for tissue engineering: In an embodiment of the disclosure, a biomedical material is provided. The biomedical material includes a biocompatible material having a surface and a carrier distributed over the surface of the biocompatible material, wherein both of the biocompatible material and the carrier have no charges, one of them has charges or... Agent:

20130059383 - Cell-culture-bag: The present invention is directed to a method to expand adherent cells comprising addition of adherent cells to an expansion container comprising microcarriers and culture medium; removing medium from the expansion container through a 8-20 mm filter; allowing cells to attach to microcarriers and keeping the expansion container in motion... Agent:

20130059384 - Compositions and methods for enhancing bioenergetic status in female germ cells: Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.... Agent: The General Hospital Corporation

20130059386 - Induced pluripotent stem cells produced with oct3/4, klf and sox: The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including... Agent: Kyoto University

20130059385 - Methods of generating pluripotent stem cells: Disclosed are methods, compositions, and kits of producing an induced pluripotent stem cell from a mammalian non-pluripotent cell that does not endogenously or heterologously express Sox2 and is not in contact with a Sox2 polypeptide.... Agent: The Scripps Research Institute

20130059387 - Meganuclease variants cleaving a dna target sequence from the hprt gene and uses thereof: A method for inducing a site-specific modification in the HPRT gene, for a non-therapeutic purpose, by contacting a DNA target sequence selected from the group consisting of the sequences SEQ ID NO: 1 to 14 thereby cleaving the DNA target with an I-CreI variant or single-chain derivative having at least... Agent: Cellectis

20130059388 - Methods for generating endogenously tagged proteins: The present disclosure provides a method for endogenously tagging an endogenous protein in a cell, and a cell comprising an endogenously tagged protein. Also described are cells produced using such a method and a kit comprising a cell having tagged endogenous protein.... Agent: Sigma-aldrich Co., LLC

20130059389 - Method for producing kluyveromyces marxianus transformant: An object to be solved by the present invention is to provide, for example, a method for producing a Kluyveromyces marxianus transformant by a method for conveniently and efficiently connecting the ends of DNA fragments without using specific restriction enzymes or their recognition sequences, and a method for producing a... Agent: Yamaguchi University