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Chemistry: molecular biology and microbiology November recently filed with US Patent Office 11/12

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
11/29/2012 > 100 patent applications in 62 patent subcategories. recently filed with US Patent Office

20120301866 - Liquid formulation having dissolved gases useful for preserving biological material: The invention relates to a liquid formulation including a liquid solution and at least one gas selected from xenon, argon, hydrogen, H2S, helium, krypton, neon, radon or CO, said gas being dissolved in said liquid solution, for the use thereof as a preservative solution for preserving biological material, in particular... Agent: L'air Liquide, Soci&#xe9 T&#xe9 Anonyme Pour I'etude Et I'exploitation Des Proc&#xe9 D&#xe9 S Georges Claude

20120301868 - Extender for a semen suspension: The present invention belongs to the veterinary field, and particularly to the field of assisted reproduction. The invention more specifically consists of a semen extender comprising alginate and the use thereof for sperm preservation and for increasing the percentage of offspring of a certain sex.... Agent:

20120301869 - Particle separation devices, methods and systems: A device, system and method for the separation and collection of sperm cells into multiple subpopulations based upon sperm characteristics and for facilitating the collection of multiple subpopulations in limited space. The device can be a redirection device including one or more spaced apart tubes, where each tube has a... Agent: Inguran, LLC

20120301867 - Recovering nucleated red blood cells and method for concentrating and recovering nucleated red blood cells: Provided is a chip or the like having a particulate concentrating mechanism such as a mechanism that can selectively concentrate nucleated red blood cells contained in maternal blood and derived from a fetus and can collect the concentrated liquid rich in nucleated red blood cells, and also provided is a... Agent: Japan Advanced Institute Of Science And Technology

20120301870 - Enhanced stability of proteins immobilized on nanoparticles: This invention is directed to the application of a previously unknown property of nanomaterials—its ability to enhance protein activity and stability at high temperatures, in organic solvents, and in polymer composites. Nanomaterials such as single-walled carbon nanotubes (SWNTs) can significantly enhance enzyme function and stability in strongly denaturing environments. Experimental... Agent: Rensselaer Polytechnic Institute

20120301871 - Comparative ligand mapping from mhc positive cells: The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules... Agent:

20120301872 - System and method for increased fluorescence detection: The invention relates to systems and methods for improving optical detection and sensitivity in situations in which emission of luminescent light is monitored. It is provided a sample carrier which achieves increased sensitivity of luminescent light detection. The sample carrier comprises a sample carrying part and a light reflecting part;... Agent: Ge Healthcare Bio-sciences Ab

20120301873 - Human long pentraxin 3 expression system and uses thereof: The present invention relates to an eukaryotic expression vector comprising a nucleotide sequence encoding for the human long pentraxin PTX3 protein under the control of an effective promoter and a nucleotide sequence encoding for a selectable marker, recombinant human cell able to provide expression of proteins encoded by the vector... Agent: Technogen S.p.a.

20120301880 - Alkyl amine compounds for fluorescent labeling: Alkyl amine dyes, oligonucleotide probes prepared from the alkyl amine dyes, phosphoramidites and solid supports prepared from the alkyl amine dyes, and methods of labeling biological agents using the alkyl amine dyes.... Agent: Blood Cell Storage, Inc.

20120301875 - Amplicon melting analysis with saturation dyes: Methods are provided for nucleic acid analysis wherein a target nucleic acid that is at least partially double stranded is mixed with a dsDNA binding dye having a percent saturation of at least 50% to form a mixture. In one embodiment, the nucleic acid is amplified in the presence of... Agent:

20120301874 - Compositions and methods for detection of staphylococcus aureus: The present invention relates to methods for the rapid detection of the presence or absence of Staphylococcus aureus in a biological or nonbiological sample. The present invention includes methods of detection comprising performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, the present invention relates to primers,... Agent: Roche Molecular Systems, Inc.

20120301881 - Compositions, methods and related uses for cleaving modified dna: Compositions, methods and a kit are described relating to a novel family of enzymes which preferentially bind to a hydroxymethylated cytosine or a glucosylated hydroxymethylated cytosine and cleave double-stranded DNA at a defined distance 3′ of the recognition site to produce a cleavage fragment with a 1-3 base overhang.... Agent: New England Biolabs, Inc.

20120301885 - Cytogenic analysis of metaphase chromosomes: The present invention relates to methods and systems for analyzing chromosomes, and in particular to methods and systems for simultaneously performing banding and in situ hybridization on metaphase chromosomes.... Agent:

20120301884 - Method and device for detecting the presence of a single target nucleic acid in a sample: A method comprising subjecting one or more sample portion(s) to a single amplification step, thereby amplifying a single molecule in the sample portion to a detectable level, and, in some embodiments, then determining whether the sample portion contains at least one molecule of the target nucleic acid. In some embodiments,... Agent: Applied Biosystems, LLC

20120301876 - Method to quantify sirnas, mirnas and polymorphic mirnas: The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3′ end of a target polynucleotide, using a ligase that can ligate the 3′ end of RNA to the 5′ end of DNA using a DNA... Agent: Life Technologies Corporation

20120301878 - Methods and compositions for the detection of drug resistant braf isoforms: The present invention provides methods and compositions for the detection of novel BRAF splice variants that mediate resistance to BRAF and/or pan-RAF inhibitors. In particular, the invention provides PCR primer(s) to be used in the disclosed methods of detection. In some embodiments, the compositions and methods of the present invention... Agent:

20120301882 - Methods for generating databases and databases for identifying polymorphic genetic markers: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.... Agent: Sequenom, Inc.

20120301879 - Novel use of ca-125: Provided is novel use of CA-125. As it is discovered that CA-125 level are positively associated with bone mineral density, thereby CA-125 can be used in biomarker to diagnose osteoporosis or osteopenia, or extent of growth plate development.... Agent: Korea University Research And Business Foundation

20120301886 - Polytag probes: The present invention provides probes and probe systems for detection of nucleic acids, and in particular probes and probe systems comprising target nucleic acid probes which comprise a plurality of detection sequences and detection nucleic acid probes which hybridize to the detection sequences of the target nucleic acid probes and... Agent:

20120301883 - Sheath flow devices and methods: The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid... Agent: Cynvenio Biosystems, Inc.

20120301877 - Use of phenanthridium derivatives for distinguishing between intact and membrane comprised cells using molecular nucleic acid-based techniques: The present invention provides novel chemicals and methods for selectively excluding DNA of dead cells from a mixture containing live and dead cells from molecular detection.... Agent: Montana State University

20120301891 - Biomarkers of cancer metastasis: There is provided a method for determining tumour metastatic potential using biomarkers of tumour metastasis comprising any two of carbonic anhydrase-9 (CAIX), vascular endothelial growth factor C (VEGF-C), ephrin A5 (EFNA5), eph receptor B2 (EPHB2), transforming growth factor beta 3 (TGF-β3), pyruvate dehydrogenase kinase isoenzyme-3 (PDK3), carbonic anhydrase-12 (CAXII), keratin... Agent: British Columbia Cancer Agency Branch

20120301887 - Gene expression profiling for the identification, monitoring, and treatment of prostate cancer: A method is provided in various embodiments for determining a profile data set for a subject with prostate cancer or a condition related to prostate cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount... Agent:

20120301889 - Method and reagents for identifying pluripotent stem cells: The present invention relates to methods for distinguishing pluripotent stem cells from partially differentiated, or spontaneously differentiated cells, and to reagents for use in such methods. In particular, the method enables the detection of alternatively spliced transcripts and the polypeptides encoded thereby, which are uniquely associated with, or present at... Agent: City Of Hope

20120301890 - Methods for identifying nucleic acid ligands: The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid ligand of a target molecule from a candidate mixture of nucleic acids, including contacting at least one target molecule with a candidate... Agent: Infoscitex Corporation

20120301888 - Nmr systems and methods for the rapid detection of analytes: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.... Agent: T2 Biosystems, Inc.

20120301892 - In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes: A method of evaluating the effect of a xenobiotic on biomarkers, such as drug transporters and drug-metabolizing enzymes in hepatocytes is provided. The method comprises the formation of a xenobiotic-stimulated biological sample, such as whole blood, which contains a plurality of cytokines. A portion of xenobiotic-stimulated biological sample is cultured... Agent: Xenotech LLC

20120301893 - Analyte detection devices, multiplex and tabletop devices for detection of analyte, and uses thereof: Devices and methods for the detection of analytes are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.... Agent: Invisible Sentinel, Inc.

20120301894 - Labeling and detection of post translationally modified proteins: Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling a biomolecules with an azide group.... Agent: Life Technologies Corporation

20120301899 - Use of novel markers of pluripotent stem cells: The disclosure relates to novel markers of pluripotent stem cells and uses thereof, and particularly, though not exclusively, to antibody molecules based on fragments of mAb84 which bind to undifferentiated pluripotent stem cells via podocalyxin-like protein-1 (PODXL).... Agent: Agency For Science, Technology And Research

20120301900 - Apparatus and method for detecting tumor cells: Provided are an apparatus for detecting tumor cells including a tumor cell detection chip and a method for detecting tumor cells. The apparatus and method for detecting tumor cells according to the present disclosure enable convenient detection of tumor cells in short time and thus allow for treatment prior to... Agent: Korea Institute Of Science And Technology

20120301895 - Methods of modulating binding of son of sevenless to phosphatidic acid and identifying compounds that modulate such binding: The present invention relates to methods of modulating binding of Son of sevenless to phosphatidic acid and identifying compounds that modulate such binding. In particular, the present invention relates to a method of controlling pleckstrin homology domain-dependent membrane recruitment of Son of sevenless or histone folds domain-dependent membrane recruitment of... Agent: New York University

20120301897 - Acetaminophen-protein adduct assay device and method: The present invention describes devices and methods for detecting and measuring the amount of acetaminophen-protein adducts in a sample.... Agent: Board Of Trustees Of The University Of Arkansas

20120301898 - Assessing non-alcoholic fatty liver disease: The document provides methods and materials related to assessing NAFLD in a mammal. For example, methods and materials for determining whether or not a mammal has an NAFLD are provided. In addition, methods and materials for determining whether a mammal with an NAFLD has a severe or mild form of... Agent:

20120301896 - Tsh antibodies for point-of-care immunoassay formats: The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically... Agent: Abbott Point Of Care Inc.

20120301901 - Gemcitabine immunoassay: The present invention comprises novel analogs of gemcitabine and novel gemcitabine immunogens leased out of, i.e., derived from, the 5′-hydroxy position of gemcitabine. The invention also comprises unique monoclonal antibodies generated using gemcitabine linked immunogens as well as unique conjugates and tracers which antibodies, conjugates, and tracers are useful in... Agent:

20120301902 - Gemcitabine immunoassay: The present invention comprises novel conjugates and immunogens derived from gemcitabine and unique antibodies generated by using gemcitabine linked immunogens, which conjugates immunogens and antibodies, are useful in immunoassays for the quantification and monitoring of gemcitabine in biological fluids.... Agent:

20120301903 - Microfluidic devices and methods of manufacture and use: Series of bio-detection elements, shown as short hollow transparent reaction vessels (32), batch-surface-coated with capture-agent, are placed in channel of larger width (a3; c8; 15; 28; 44), and fixed by flexible or elastomeric over-lying sheet (a1; c7; 13; 38). Portions of sheet form pneumatically-activated pistons (22; 36) and valves (23-27;... Agent:

20120301904 - Multiprotein assemblies: The present invention provides compositions and methods of use in investigations of the formation of mulitprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.... Agent: Prosetta Antiviral, Inc

20120301905 - Tsh immunoassays and processes for performing tsh immunoassays in the presence of endogenous contaminants in restricted wash formats: The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating... Agent: Abbott Point Of Care Inc.

20120301906 - Tsh immunoassays employing scavenging reagents for cross-reacting endocrine glycoprotein hormone analogues: The invention relates to Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay that employs scavenging or sacrificial beads for reducing interference caused by cross-reacting endocrine glycoprotein hormone analogues such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).... Agent: Abbott Point Of Care Inc.

20120301907 - Methods, devices, and systems of detecting microorganisms: A rapid, sensitive method of separating and detecting microorganisms from a sample potentially containing microorganisms, such as but not limited to bacteria, fungi, yeast, viruses, and the like. The method relies on separation techniques to separate and concentrate the cells from the sample, together with chemical techniques to amplify the... Agent: Celsis Ltd.

20120301908 - Method for determining the reliability of a device for measuring the concentration of a substance in whole blood, method for treating whole blood, container and kit: The present invention pertains to the field of measuring the concentration of a substance in whole blood and relates to a method for determining the reliability of a device for measuring the concentration of a substance in whole blood, and to a method for treating whole blood, wherein a cell-free... Agent: Eurotrol B.v.

20120301909 - Sulfotransferase assay: Assays and methods for detecting and/or quantifying activity of a test sulfotransferase comprising by releasing a free phosphate from the PAP produced by the sulfotransferase reaction and detecting the free phosphate. The assay can includes gPAPP, a free phosphate detector and an optional control sulfotransferase. The method includes combining a... Agent: Research And Diagnostic Systems, Inc.

20120301910 - Detection of lysophosphatidylcholine for prognosis or diagnosis of a systemic inflammatory condition: The present invention provides methods and compositions useful for the diagnosis or prognosis of a systemic inflammatory condition such as sepsis.... Agent: Becton, Dickinson And Company

20120301911 - Rapid detection of molds that produce glucose oxidase: Methods and kits are disclosed for detecting microorganisms that produce glucose oxidase. The method includes providing a culture medium and a hydrogen peroxide indicating reagent comprising a chromogenic substrate that can provide a detectable chromogenic reaction indicating the presence of a microorganism that produces glucose oxidase, and additional methods are... Agent:

20120301914 - High resolution label-free sensor: t

20120301912 - Methods, compositions and kits for assaying mitochondrial function: The invention provides methods, compositions, devices, and kits relating to the use of cholesterol-dependent cytolysins (e.g., PFOs) for measuring intracellular mitochondrial activity.... Agent: Baystate Medical Center, Inc.

20120301913 - Microplate assemblies for flux determination by gradient monitoring and methods for using same: Microplate assemblies and methods for using same are provided. In accordance with some embodiments, microplate assemblies are provided, the assemblies comprising a microplate well portion that forms a microplate well and that includes at least one sensor in the microplate well that responds to analyte in the well. In accordance... Agent:

20120301915 - System and automated device for analysing a cell suspension: A system for analyzing a cell suspension includes at least one well for decanting (1) the suspension and elements (2, 3) for analyzing the cell deposits at the bottom of the well over time during the decanting, so as to allow an analysis of the cells by strata (T1, T2,... Agent: Novacyt

20120301916 - Growth medium for the detection of microorganisms by fluorescence allying a fluorogenic substrate and a ph-sensitive fluorophore: The invention relates to a growth medium allying a fluorogenic substrate and a pH-sensitive fluorophore, in particular the combination of 4-methylumbelliferone (4-MU) and derivatives of fluorescein. This growth medium is used for the detection by fluorescence of microorganisms by coupling the fluorescence measurements relating to the pH-sensitive fluorophor and the... Agent: Emd Millipore Corporation

20120301917 - Hydrophilic ir transparent membrane, spectroscopic sample holder comprising same and method of using same: The present invention features hydrophilic IR-transparent porous membranes, particularly hydrophilic IR-transparent porous polyethylene membranes and methods of preparing the hydrophilic membranes by treatment of hydrophobic IR-transparent porous membranes with plasma. The present invention further features spectroscopic sample holders which incorporate the hydrophilic IR-transparent porous membranes and methods of identifying bacteria... Agent: The Government Of The United States Of America, As Represented By The Secretary, Department Of

20120301918 - Method for producing alpha-l-aspartyl-l-phenylalanine-beta-ester and method for producing alpha-l-aspartyl-l-phenylalanine-alpha-methyl ester: A method of producing an α-L-aspartyl-L-phenylalanine-β-ester by forming the α-L-aspartyl-L-phenylalanine-β-ester from L-aspartic acid-α,β-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to selectively link L-phenylalanine to an α-ester site of the L-aspartic acid-α,β-diester through a peptide bond.... Agent: Ajinomoto Co., Inc.

20120301922 - Novel p. pastoris pastoris promoters, and the use thereof to direct expression of proteins in yeast, preferably using a haploid mating strategy: Novel promoters which are derived from P. pastoris pastoris which are inducible or repressible under specific growth conditions are provided. These promoters are useful for regulating the expression of a desired structural gene, e.g., a mammalian polypeptide. Particularly preferred is the use of these novel promoters to regulate gene expression... Agent:

20120301920 - Bacterial host strain comprising a mutant spr gene and a wild-type tsp gene: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a mutant spr protein and wherein the cell comprises a non-recombinant wild-type chromosomal Tsp gene.... Agent: Ucb Pharma, S.a.

20120301919 - Ires mediated multicistronic vectors: This invention relates to nucleic acid molecules comprising at least one nucleic acid sequence encoding for a peptide or protein of interest, at least one nucleic acid sequence encoding for a selectable marker, and at least one IRES sequence, wherein the at least one IRES sequence is located between the... Agent: Agency For Science, Technology And Research

20120301921 - Compositions and methods of treating disease with fgfr fusion proteins: The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their... Agent: Five Prime Therapeutics, Inc.

20120301923 - Dialysis fermenter-bioreactor with dialysis device: The present disclosure provides systems and methods of using a semipermeable membrane in a dialysis fermenter as a separation layer between a cell-containing liquid culture medium and a non-cell-containing dialysis medium. In some embodiments, the semipermeable membrane may have a molecular cut-off of 15 kDa to 50 kDa. The instant... Agent: Roche Diagnostics Operations, Inc.

20120301924 - Method for incubating the contents of a receptacle: In a computer-controlled, automated method, a nucleic acid amplification procedure is performed within a prescribed incubation temperature range within an instrument that comprises at least one thermal element situated at a first location of the instrument and an amplification incubator situated at a second, spaced-apart location of the instrument. A... Agent: Gen-probe Incorporated

20120301925 - Methods and compositions for dna fragmentation and tagging by transposases: The present invention provides new compositions for transposase-mediated fragmenting and tagging DNA targets. The invention relates to the surprising discovery that use of manganese ions (Mn2+) in transposase reactions improves the transposase reaction. It also relates to the surprising discovery that Mg2+ ions can be used in a transposase reaction... Agent:

20120301926 - Methods for manipulating biomolecules: In some embodiments, the present teachings provide compositions, systems, methods and kits for generating a population of nucleic acid fragments. In some embodiments, nucleic acids can be fragmented enzymatically. For example, methods for generating a population of nucleic acid fragments can include a nucleic acid nicking reaction. In one embodiment,... Agent: Life Technologies Corporation

20120301927 - Production of maltotetraose syrup using a pseudomonas saccharophila maltotetraohydrolase variant: Variants of a Pseudomonas saccharophila G4-forming amylase (PS4) advantageously can catalyze high temperature saccharification to produce maltotetraose syrup from a starch liquefact or granular starch, e.g., derived from cornstarch. The PS4 variants are useful in a process of saccharification of starch that advantageously produces significant amounts of maltotetraose, which can... Agent: Danisco US Inc.

20120301930 - Bio-engineered multi-enzyme complexes comprising xylanases and uses thereof: The present invention relates to bio-engineered multi-enzyme complexes having synergistic enzyme activity comprising xylanases and optionally further comprising additional carbohydrate active enzymes. Such complexes are advantageous for degrading recalcitrant cellulosic biomass.... Agent: Yeda Research And Development Co. Ltd.

20120301929 - Method for degrading organic material using mother cell lyases formed in association with spore formation of microorganism: Provided is a method for degrading an organic material. Also provided is a useful low-molecular organic material. The method for degrading an organic material is characterized by comprising a step for preparing the organic material to be degraded, and a step for treating said organic material with mother cell lytic... Agent: Meisho Co., Ltd.

20120301928 - Preprocessing method of hydrolyzing lignocellulosic biomass and methods of manufacturing sugar compound and bioethanol from biomass processed using the preprocessing method: The present invention relates to a method of pretreating lignocellulosic biomass prior to hydrolysis, and, more particularly, to a method of pretreating lignocellulosic biomass prior to hydrolysis using wet milling in combination with popping, a method of manufacturing a sugar compound from the biomass pretreated using the method, and a... Agent: Industry Foundation Of Chonnam National University

20120301931 - Process for the reduction of cinnamaldehyde derivative employing enoate reductases: The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.... Agent: Basf Se

20120301932 - Expression of caleosin in recombinant oleaginous microorganisms to increase oil content therein: Recombinant oleaginous microorganisms having increased oil content due to the expression of a caleosin polypeptide are described. A recombinant oleaginous microorganism of the disclosed invention produces at least 25% of its dry cell weight as oil, and comprises a functional polyunsaturated fatty acid (PUFA) biosynthetic pathway and at least one... Agent: E I Du Pont De Nemours And Company

20120301933 - Pha-producing bacteria: The present disclosure relates to isolated bacterial strains producing polyhydroxyalkanoate (PHA), microbial consortia including such strains, and cultures of such strains and microbial consortia. In particular, the present disclosure relates to compositions including such strains, microbial consortia, and cultures and methods of use thereof.... Agent: Micromidas, Inc.

20120301934 - Process for the production of esters: Methods for producing an ester from a gas comprising carbon monoxide. More specifically the invention provides for methods for producing one or more products by the anaerobic fermentation of a gaseous substrate comprising CO and the subsequent conversion of the one or more products to an ester in a down-stream... Agent: Lanzatech New Zealand Limited

20120301935 - Recombinant microorganism for simultaneously producing 3-hydroxypropionic acid and 1,3 propanediol: A method of simultaneously producing 3-hydroxypropionic acid (3-HP) and 1,3-propanediol (1,3-PDO) using a microorganism is provided. The method includes converting glycerol into 3-HP and 1,3-PDO using a recombinant microorganism having both 3-HP and 1,3-PDO producing genes.... Agent: Samsung Electronics Co., Ltd.

20120301936 - Recombinant mutant microorganisms having increased ability to produce alcohols and method of producing alcohols using the same: The present invention relates to recombinant mutant microorganisms having an increased ability to produce alcohol and a method of producing alcohol using the same, and more particularly to recombinant mutant microorganisms which have an increased ability to produce butanol, ethanol, isopropanol or mixed alcohols, which can be used as fuel,... Agent: Biofuelchem Co.

20120301937 - Methods for producing and harvesting ethanol and apparatus for producing and harvesting the same: The invention relates to methods for producing and harvesting ethanol from fermentable sugars derived from sugar crops, starch-containing and lignocellulose-containing materials, and apparatuses for producing and harvesting the same.... Agent: Scale Biofuel, Aps

20120301938 - Method and apparatus for continuous flow bio-fuel production: A continuous flow system for production of bio-fuels using microbial cultures is provided. The present invention does not utilize batch type production, but follows a continuous flow protocol that eliminates much downtime inherent in conventional bio-fuel production systems while greatly reducing space and equipment requirements. Production is enhanced via controlled... Agent:

20120301939 - Methods of treating biomass: A process for producing biofuel from biomass that includes free monosaccharides is provided. The process comprises the steps of mixing the biomass with a recycled hydrolysate for a sufficient time to elute a portion of the free monosaccharides from the biomass thereby forming a sugar enriched hydrolysate. Sugar enriched hydrolysate... Agent:

20120301940 - Method for pretreating crude oil using microorganism: A method for pretreating a crude oil prior to a crude oil distillation process comprising the step of propagating a culture of a hydrocarbon-utilizing and biosurfactant-producing microbial strain and treating the crude oil with the propagated culture.... Agent:

20120301941 - Novel glycosyltransferases and polynucleotides encoding the same: The present invention provides novel glycosyltransferase proteins produced by ascomycetous filamentous fungi (preferably species belonging to the genus Trichoderma, more preferably Trichoderma viride), as well as genes encoding the same. Among novel enzyme proteins provided by the present invention, particularly preferred is an enzyme protein obtained from the culture supernatant... Agent: Suntory Holdings Limited

20120301942 - Chip provided with film having hole pattern with the use of thermoresponsive polymer and method of producing the same: A chip useful for treating cells and the like which has a mechanism and a structure wherein the size of a hole pattern is arbitrarily changed so that cells can easily move in and get out from the hole in scattering or collecting cells but can hardly get out from... Agent: Nissan Chemical Industries, Ltd.

20120301943 - Dry reagent, dry reagent kit, reagent container, and method for producing dry reagent: The present invention provides a dry reagent capable of amplifying a nucleic acid even after being stored in a dry state at room temperature, a dry reagent kit, a reagent container, and a method for producing the dry reagent and methods of producing and using thereof.... Agent: Arkray, Inc.

20120301944 - Bgl6 beta-glucosidase and nucleic acids encoding the same: The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding BGL6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL6, recombinant BGL6 proteins and methods for producing the same.... Agent: Danisco US Inc.

20120301945 - Protease screening methods and proteases identified thereby: Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha... Agent: Molecular Studies And Catalyst Biosciences, Inc.

20120301946 - Thermolysin for easy-cleaning of insect body stains: A substrate or coating is provided that includes a protease with enzymatic activity toward a component of a biological stain. Also provided is a process for facilitating the removal of a biological stain is provided wherein an inventive substrate or coating including a protease is capable of enzymatically degrading of... Agent: Toyota Motor Engineering & Manufacturing North America, Inc.

20120301947 - Enzymatic systems for carbon fixation and methods of generating same: A system for carbon fixation is provided. The system comprises enzymes which catalyze reactions of a carbon fixation pathway, wherein at least one of the reactions of the carbon fixation pathway is a carboxylation reaction, wherein products of the reactions of the carbon fixation pathway comprise oxaloacetate and malonyl-CoA, wherein... Agent: Yeda Research And Development Co. Ltd.

20120301949 - Method and system for producing hydrogen from carbon-containing raw materials: The invention refers to a process to produce H2 from biomass containing carbon. The biomass is gasified to obtain a gaseous flow essentially containing molecules of carbon monoxide (CO) and molecules of molecular hydrogen (H2). These molecules (CO) and (H2) are then oxidized by oxygen holders in oxidized state (MeO)... Agent: See - Solu&#xc7 &#xd5 Es, Energia E Meio Ambiente Ltda.

20120301948 - Novel method of acid hydrolysis of biomass and the recovery of sugars thereof by solvent extraction: The present invention provides for a method of hydrolyzing a cellulose, hemicellulose, or ligno-cellulose comprising: (a) contacting (i) an ionic liquid (IL) or ionic liquid-aqueous (ILA) phase comprising cellulose, hemicellulose, or ligno-cellulose, or a mixture thereof, and (ii) an acid, such that the cellulose, hemicellulose, or ligno-cellulose is hydrolyzed into... Agent: The Regents Of The University Of California

20120301950 - Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks: Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.... Agent:

20120301951 - Prevention of contamination of nutrient feed reservoirs & feed lines in bioreactor systems: A method to prevent contamination of feed line(s) and nutrient feed reservoirs(s) is disclosed. In this method the growth medium which flows from the nutrient feed reservoir through the feed line to the bioreactor contains at least one nutritional component supplied at a concentration which is inhibitory to cell growth.... Agent: E. I. Du Pont De Nemours And Company

20120301952 - System for hypothermic transport of samples: A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend the sample in preservation fluid, and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a... Agent: Paragonix Technologies, Inc.

20120301953 - Graphene nanomesh and method of making the same: A graphene nanomesh includes a sheet of graphene having a plurality of periodically arranged apertures, wherein the plurality of apertures have a substantially uniform periodicity and substantially uniform neck width. The graphene nanomesh can open up a large band gap in a sheet of graphene to create a semiconducting thin... Agent: The Regents Of The University Of California

20120301954 - Sensor attachment arrangement for flexible bags: an adaptor part provided outside the flexible bag and adapted to hold an optical fibre, said adaptor part comprising second locking means adapted to mate with said first locking means to lock the two parts together such that the optical fibre can communicate with the optical sensor inside the bag.... Agent: Ge Healthcare Bio-sciences Ab

20120301955 - Modified messenger rna stabilizing sequences for expressing genes in bacterial cells: The present invention relates to methods of producing a polypeptide having biological activity in a bacterial cell, comprising: (a) cultivating a bacterial host cell in a medium conducive for production of the polypeptide, wherein the bacterial host cell comprises a nucleic acid construct comprising a promoter region operably linked to... Agent: Novozymes, Inc.

20120301957 - Method and apparatus for collecting biological materials: A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is... Agent: Biomet Biologics, LLC

20120301956 - Novel hydroxylated enantiomers of (-) 3a,6,6,9a-tetramethylperhydronaphtho[2,1-b]furan as perfuming agents derived from a fungal fermentation process: (−)3a,6,6,9a-tetramethylperhydronaphtho[2,1-b]furan (ambrox) is a strong aromatic compound used widely in a variety of perfumery applications and is highly prized for its musky odor. We report novel polar metabolites of (−)3a,6,6,9a-tetramethylperhydronaphtho[2,1-b]furan prepared by a novel process of microbial fermentation using a fungi, Fusarium lini, of unique structures that would be difficult... Agent:

20120301958 - Bioartificial proximal tubule systems and methods of use: This application invention discloses bioartificial proximal tubule device, constructed by preparing a decellularized biological matrix, seeding the biological matrix with mammalian kidney-derived cells and optionally mammalian endothelial cells. The device may then be cultured statically or matured using bioreactor culture to allow differentiation of the kidney cells into functioning proximal... Agent: Advanced Technologies And Regenerative Medicine, LLC

20120301959 - Cryoconserved mature dendritic cells: The invention relates to a method for producing ready to use, antigen loaded or unloaded, cryoconserved mature dendritic cells especially for the production of a vaccine containing said dendritic cells, wherein immature dendritic cells are cultivated in the presence of suitable maturation stimuli and the mature dendritic cells thus obtained... Agent: Argos Therapeutics, Inc.

20120301960 - Lance device and associated methods for delivering a biological material into a cell: Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip... Agent: Brigham Young University

20120301961 - Polypeptide having affinity for envelope virus constituent and use thereof in transferring substance into cell: Delivery proteins are provided for transferring a protein, antibody or foreign substance into a cell without impairing the function or structure thereof. Further, methods of transferring a foreign substance into a cell at a high efficiency by using the delivery protein or an envelope virus or inactivated envelope virus in... Agent:

20120301962 - Vitronectin-derived cell culture substrate and uses thereof: Vitronectin-derived cell culture substrates and methods of using the same for culturing pluripotent stem cells are presented.... Agent:

20120301963 - Covered micro gel fiber: A microfiber showing improved mechanical strength, which comprises a micro gel fiber consisting of collagen gel or the like covered with high strength hydrogel such as alginate gel.... Agent: The University Of Tokyo

20120301964 - Methods and compositions for genetically engineering clostridia species: The present invention relates to methods and compositions for engineering Clostridia species. In particular, embodiments of the present invention relate to the expression of recombinant resolvase proteins in Clostridia species.... Agent: Northwestern University

20120301965 - Cell programming: The present invention is concerned with methods for reprogramming of mammalian somatic cells and in particular to reprogramming of mature mammalian somatic cells into multi-potent precursor cells.... Agent: Auckland Uniservices Limited

  
11/22/2012 > 112 patent applications in 63 patent subcategories. recently filed with US Patent Office

20120295245 - Dermal micro-organs, methods and appratuses for producing and using the same: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived, having dimensions... Agent:

20120295246 - Blood cell sorting methods and systems: The invention relates to methods of isolating white blood cells (WBCs) from a sample, e.g., whole blood, using magnetic particles that specifically bind to WBCs and a series of specific steps and conditions. The methods can include one or more of decreasing the viscosity of the sample prior to WBC... Agent: The General Hospital Corporation

20120295247 - Porcine seminal material composition for artificial insemination of sows: A porcine seminal material composition intended for artificial insemination of sows includes capsules containing a suspension made of porcine seminal material coated with a bi-valent or tri-valent ion alginate film, wherein the porcine spermatozoon concentration within the porcine seminal material suspension present in the capsules is between 900 and 1500... Agent: Genes Diffusion

20120295248 - Systems and methods for dynamic gas control in a disposable vessel: A disposable mixing vessel incorporates a system for dynamic gas control. The disposable mixing vessel includes a first agitating element and a second agitating element located above the first agitating element. The system for dynamic gas control enables a cell culture process to occur in the disposable mixing vessel while... Agent:

20120295251 - Determining codon distribution and/or base pair distance between codons in a nucleic acid: The present invention relates to methods for the design and/or production of a probe or primer that is capable of hybridizing to a plurality of sites in a sample comprising nucleic acid. Furthermore, the present invention provides methods for detecting and amplifying nucleic acid using such a probe or primer,... Agent:

20120295249 - Instrument and method for the automated thermal treatment of liquid samples: An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal... Agent: Roche Diagnostics Operations, Inc.

20120295250 - Microchip, measurement system and method using the same, and test reagent to be used for microchip: A microchip to be used for measuring a plurality of types of objects to be measured. The microchip includes at least a reagent retaining portion and a detecting portion. The test reagent retaining portion includes a plurality of types of test reagents corresponding respectively to the plurality of types of... Agent: Rohm Co., Ltd.

20120295252 - Composition for analyzing nucleic acid: A composition for analyzing nucleic acid that contains luciferase for which reactivity to dATP is equal to or less than 1/400 reactivity to ATP. A method for analyzing nucleic acid that comprises the use of the composition. A kit for analyzing nucleic acid comprising the composition. The method provides for... Agent: Kikkoman Corporation

20120295253 - Dynamic monitoring of activation of receptor tyrosine kinase (rtk) in living cells using real-time microelectronic cell sensing technology: Methods for identifying a compound capable of interacting with a Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance, adding test cells expressing a RTK to the device, measuring first impedances, adding a compound to at least one compound well and adding a vehicle control at... Agent:

20120295263 - Haplotype analysis: The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic acid markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these... Agent: Trustees Of Boston University

20120295264 - Method for detecting ulcerative colitis: An object of the present invention is to provide a method of detecting an inflammatory bowel disease, and particularly ulcerative colitis, by using a component contained in fecal matter as an indicator. Namely, the present invention provides a method for detecting ulcerative colitis comprising: (A) a step of extracting RNA... Agent: National University Corporation Hamamatsu University School Of Medicine

20120295255 - Method for high resolution melt genotyping: Various methods are described that provide for high resolution melt (HRM) genotyping. The embodiments include providing a locus specific primer and two allele specific primers each having a 5′ end with a short tail, providing a nucleic acid having a single nucleotide polymorphism (SNP) base located within 1-20 base pairs... Agent: Life Technologies Corporation

20120295261 - Method for the in vitro diagnosis of bronchopulmonary carcinoma by detection of major alternative transcripts of the klk8 gene encoding kallicrein 8 and use thereof for prognosticating survival: A method for the in vitro diagnosis of bronchopulmonary carcinoma, in particular of non-small cell bronchial carcinoma, that includes a stage of detecting, in a biological sample derived from a patient suspected to be suffering from bronchopulmonary carcinoma, at least one of the major alternative transcripts of the KLK8 gene... Agent: Biomerieux

20120295257 - Method, microchip and mixed reagent for analysis of nucleic acid base sequence: A technology is provided for achieving high efficiency of nucleic acid amplification reaction and high precision of melting curve analysis when performing melting curve analysis in a nucleic acid amplification process of obtaining an amplification product in which the target nucleic acids are continuously arranged via a loop. A method... Agent: Sony Corporation

20120295260 - Methods for accurate sequence data and modified base position determination: Disclosed herein are methods of determining the sequence and/or positions of modified bases in a nucleic acid sample present in a circular molecule with a nucleic acid insert of known sequence comprising obtaining sequence data of at least two insert-sample units. In some embodiments, the methods comprise obtaining sequence data... Agent: Industrial Technology Research Institute

20120295259 - Methods for determining the likelihood of survival and for predicting likelihood of metastasis in cancer patients: The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating the risk of brain relapse in such patients.... Agent: Laboratory Corporation Of America Holdings

20120295262 - Multibase delivery for long reads in sequencing by synthesis protocols: The present technology relates to molecular sciences, such as genomics. More particularly, the present technology relates to methods for obtaining long lengths of sequencing data.... Agent: Illumina, Inc.

20120295254 - Pna probes, mixtures, methods and kits pertaining to the determination of mycoplasma and related mollicutes: This invention is related to PNA probes, probe sets, mixtures, methods and kits pertaining to the determination of Mycoplasma and related Mollicutes.... Agent: Life Technologies Corporation

20120295258 - Utility of b-raf dna mutation in diagnosis and treatment of cancer: The present invention discloses a method of detecting a wild-type or mutant B-RAF gene in a body fluid sample from a subject. Also disclosed are methods of using B-RAF as a biomarker for detecting cancer, predicting the outcome of cancer, and monitoring the treatment of cancer or the status of... Agent: John Wayne Cancer Institute

20120295256 - Weight management genetic test systems and methods: Disclosed herein is a nutritional genomic weight management algorithm running on a computer system, and more specifically, a nutritional genomic weight management algorithm where an analysis of a customer's unique DNA results in individualized diet and exercise plans, in accordance with the present invention. Methods of weight management, weight management... Agent: Genovive LLC

20120295267 - Detecting dna mismatch repair-deficient colorectal cancers: Use of a CAT25 mononucleotide marker in a novel tetraplex PCR for the detection of MSH6-defective colorectal cancers (CRCs) is described herein. The tetraplex PCR of the present invention offers a facile, robust, less expensive (compared to the original pentaplex assay), highly sensitive, and specific assay for the identification of... Agent: Baylor Research Institute

20120295271 - Genotyping hla loci: This invention provides for an improved method for genotyping HLA loci using PCR.... Agent: Linkage Biosciences, Inc.

20120295268 - Instrument and method for detecting analytes: The present disclosure provides instruments and methods for detecting an analyte which are capable of exciting a plurality of luminescence labels and detecting light emitted therefrom. The instrument includes a filter carrier adapted for carrying a plurality of filter portion pairs, each pair related to a luminescence label and comprising... Agent: Roche Diagnostics Operations, Inc.

20120295269 - Method for separating an analyte from a sample: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge... Agent: Cepheid

20120295266 - Methods and systems for molecular fingerprinting: This invention relates in general to a method for molecular fingerprinting. The method can be used for forensic identification (e.g. DNA fingerprinting, especially by VNTR), bacterial typing, and human/animal pathogen diagnosis. More particularly, molecules such as polynucleotides (e.g. DNA) can be assessed or sorted by size in a microfabricated device... Agent: California Institute Of Technology

20120295270 - Methods of using improved polymerases: This invention provides for methods of sequencing and performing polymerase reactions using an improved generation of nucleic acid polymerases. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the processivity of the polymerase.... Agent: Bio-rad Laboratories, Inc.

20120295265 - Systems and methods for enhanced scoda: Methods and apparatus for separating, concentrating and/or detecting molecules based on differences in binding affinity to a probe are provided. The molecules may be differentially modified. The molecules may be differentially methylated nucleic acids. The methods can be used in fields such as epigenetics or oncology to selectively concentrate or... Agent: The University Of British Columbia

20120295272 - Proinflammatory nucleic acids: The present invention provides compositions and methods for identifying and utilizing proinflammatory nucleic acids. In particular, this invention relates to compounds, particularly oligonucleotides, which exert their effect through triggering receptors expressed by myeloid cells (TREMs), specifically TREM 2.... Agent: Isis Pharmaceuticals, Inc.

20120295277 - Device and method for detecting the presence of hemoglobin in a biological sample: A device and method for detecting the presence of hemoglobin in a biological sample, more particularly, the presence of blood in a fecal sample as an indicator of upper or lower gastrointestinal tract bleeding.... Agent: Quest Diagnostics Investments Incorporated

20120295278 - Fluorescence detecting method, method for producing fluorescent beads, and fluorescent beads: Two or more kinds of fluorescent beads containing at least two kinds of basic fluorochromes different in fluorescence intensity, fluorescence wavelength, and fluorescence relaxation time from each other, wherein a content ratio between the at least two kinds of basic fluorochromes and absolute amounts of contents of the basic fluorochromes... Agent: Mitsui Engineering & Shipbuilding Co.,ltd.

20120295276 - Mass spectral analysis: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis.... Agent: Purdue Research Foundation (prf)

20120295275 - Monoclonal antibodies and uses thereof: The technology relates to monoclonal antibodies useful in the identification of cancer cells. In one embodiment, mAbs with specificity for tumor antigens are provided. In one embodiment, methods for treating cancer using mAbs are provided. In another embodiment, methods for detecting cancerous cells are provided. In another embodiment, kits for... Agent: Sanofi Pasteur, Ltd.

20120295273 - N-acetylhexosamine-containing n-glycans in glycoprotein products: The present invention provides methods of evaluating a glycoprotein preparation for the absence, presence or amount of an N-acetylhexosamine glycan, e.g., an N-acetylglucosamine glycan.... Agent:

20120295279 - Pretreatment solution for immunohistochemical staining and condensed solution thereof: Disclosed are a pretreatment solution for immunohistochemical staining, which elutes a paraffin-containing embedding medium from a glass slide with a tissue specimen embedded in the medium, and retrieves antigenicity of the tissue specimen, and which is usable three or more times, and a pretreatment solution concentrate for immunohistochemical staining which... Agent: Nichirei Biosciences Inc.

20120295274 - Reporter vector presenting extracellular binding capacity to metallic compounds: According to one embodiment, a reporter vector presenting an extracellular binding capacity to metallic compounds contains a nucleotide sequence exhibiting a promoter activity depending on a specific condition, a nucleotide sequence encoding a metallic compound-binding peptide presented extracellularly, and a nucleotide sequence encoding transcription termination signals.... Agent:

20120295284 - Fluorecent saccharide conjugates: The present invention relates to improved fluorescently labeled monosaccharide and low molecular weight oligosaccharide conjugates for immunofluorescent staining, confocal microscopic imaging and flow cytometry/fluorescence activated cell sorting (FACS). These fluorophore conjugates target cells, components of cell surfaces and extracellular components; and are useful as probes for tumor targeting and cellular... Agent: B&g Partners, LLC

20120295285 - Ordered assembly of membrane proteins during differentiation of erythroblasts: Disclosed herein are methods for the isolation, identification, and quantification of red blood cells and red blood cell precursors at different developmental stages. Also disclosed are methods for monitoring ex vivo proliferation and differentiation of red blood cells and red blood cell progenitors.... Agent: New York Blood Center, Inc.

20120295280 - Citrullinated peptides for diagnosing and prognosing rheumatoid arthritis: The present invention provides novel citrullinated peptides, their use in methods for aiding, assisting, improving, or facilitating the diagnosis or prognosis of rheumatic diseases such as rheumatoid arthritis (RA), and methods for identifying novel citrullinated peptides that are immunoreactive with anti-citrullinated protein antibodies (ACPAs). The present invention also provides methods... Agent: Prometheus Laboratories Inc.

20120295282 - Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer: The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are... Agent: The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.

20120295281 - Specific salivary biomarkers for risk detection, early diagnosis, prognosis and monitoring of alzheimer's and parkinson's diseases: Methods by which specific biomarkers in saliva are used for risk detection, early diagnosis, prognosis and monitoring of Alzheimer's and Parkinson's diseases.... Agent: Bamburgh Marrsh LLC

20120295283 - Fluorescent molecular probes for use in assays that measure test compound competitive binding with sam-utilizing proteins: Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that... Agent: Cayman Chemical Company, Incorporated

20120295286 - Methods for the diagnosis, prognosis and monitoring of cancer therapy using bp1: The invention described herein relates to method for diagnosing or monitoring the progression of a cancer, e.g., breast cancer, prostate cancer or brain cancer, in a subject by determining the amount of one or more biomarkers in a bodily fluid sample, where the biomarkers comprise pBP1. The invention described herein... Agent: The George Washington University

20120295287 - Preparing hapten-specific antibodies and their application for immunodiagnostics and research: This document provides methods and materials related to detecting neurotransmitters and other biologically active small molecules. For example, methods for detecting and measuring hapten levels in a biological sample using antibodies specific for conjugated haptens are provided.... Agent: Pharmasan Labs, Inc.

20120295289 - Device and method for culturing cells: A device and method for culturing cells is described. Culture media is continuously or intermittently delivered to the cell culture for diluting concentration of at least one marker component in the cell culture. The concentration of the marker component may be measured continuously or intermittently to determined the culture media... Agent: The Governing Council Of The University Of Toronto

20120295290 - Magnetic beads for reducing leukocyte interference in immunoassays: Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes in the sample to the magnetic sacrificial beads, and magnetically retaining the... Agent: Abbott Point Of Care Inc.

20120295288 - Serological marker for detecting pancreatic cancer and a method for using the serological marker: UL16 binding protein 2 (ULBP2) is a protein overexpressed in pancreatic cancer tissues, and the ULBP2 levels are significantly higher in pancreatic cancer patients than those in healthy controls. This invention provides a method to detect pancreatic cancer using ULBP2 as a serological marker. The combination of ULBP2 and CA19-9... Agent:

20120295291 - Method for determining the risk of clopidogrel resistance: The present invention relates to a method for identifying patients for whom there is a high probability of their not benefiting from therapy with clopidogrel. It was found that the thrombocyte activity of a patient makes it possible to establish, even before the intake of clopidogrel, whether the patient has... Agent: Siemens Healthcare Diagnostics Products Gmbh

20120295292 - Detecting protein arginine deiminase (pad) activity in human tissues and sera: Methods for diagnosing disease that is characterized by an overabundance of citrullinated proteins such as colitis, rheumatoid arthritis, and/or malignant cancer in a subject are provided. The PAD protein activity level can be measured in a tissue sample (e.g., serum) of the subject and then compared to a control PAD... Agent: University Of South Carolina

20120295294 - Enzymatic method for preparing aspartam: An improved method is described for the synthesis of aspartame using a condensation reaction between the alpha-carboxyl group of the L-aspartic acid and the amino group of the methyl L-phenylalaninate catalyzed by an enzyme. The method allowed efficient and cost effective production of aspartame. A method of identifying an enzyme... Agent: Genscript Nanjing

20120295293 - Novel enhanced surface area conico-cylindrical flask (es-ccf) for biofilm cultivation: A novel enhanced surface area conico-cylindrical flask (ES-CCF) providing increased surface area by virtue of its' inner arrangement and useful in routine small-scale studies of bioactives production by any biofilm-forming marine as well as terrestrial microorganisms. Compared to corresponding Erlenmeyer flask of similar volume the ES-CCF provides more than 80%... Agent: Council Of Scientific & Industrial Research And School Of Environmental Studies

20120295295 - Detecting isomers using differential derivatization mass spectrometry: Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization,... Agent: Perkinelmer Las, Inc.

20120295297 - Assay method using encoded particle-based platform: Provided is an assay method using an encoded particle-based platform. In the assay method, first, a plurality of encoded particles having codes distinguishable from one another according to kinds of included target materials are prepared. The plurality of encoded particles are provided onto a plate including a plurality of wells... Agent: Snu R&db Foundation

20120295296 - Chlorite in the treatment of neurodegenerative disease: The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood... Agent:

20120295298 - Ex vivo method for determining potential glp-2 receptor modulators: Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue.... Agent: Nps Pharmaceuticals, Inc.

20120295299 - Method and apparatus for rapidly analyzing microorganisms using petri plates: A growth plate or Petri plate and a method for detection and identification of microorganisms by specific or non-specific staining of colonies or microcolonies is described. Analytical substances (chromogenic or fluorogenic substrates, biochemical dyes, dyes indicators of pH, antibiotics and other biological active substances) are applied to the lower surface... Agent:

20120295301 - Floating bacteria trapping device, floating bacteria counting method and floating bacteria counting system: A floating bacteria counting device capable of trapping floating bacteria in air continuously for a long time without decreasing trapping efficiency even if the time before a trapping carrier being replaced is prolonged and a floating bacteria counting method and a floating bacteria counting system using the floating bacteria trapping... Agent:

20120295302 - Magnetic separation of rare cells: A magnetic separation system configured to separate with high qualitative and quantitative yield magnetized cells from cell mixtures, comprising at least one electromagnet structured to generate a magnetic field flux about a plurality of separation zones and sufficient to attract a majority of the magnetized cells in the mixture, and... Agent: Biocep Ltd.

20120295300 - Viability cell counting by differential light absorption: Cell counts that distinguish between live and dead cells while providing an accurate count of the total of live and dead cells are obtained by the use of a vital stain in conjunction with illumination of the cell population and the taking of light images at different wavelengths, one which... Agent: Bio-rad Laboratories, Inc.

20120295303 - Photosynthetic organisms and cells adapted to metabolize phosphite as a source of phosphorus: System, including methods and compositions, for making and using photosynthetic organisms and cells that are adapted transgenically to metabolize phosphite as a source of phosphorus for supporting growth.... Agent: Centro De Investigacion Y De Estudios Avanzados Del Instituto Politecnico Nacional (cinvestav)

20120295305 - Cysteine protease autoprocessing of fusion proteins: Disclosed are fusion proteins, polynucleotides that encode the disclosed fusion proteins, and methods for expressing and autoprocessing of the disclosed fusion proteins to obtain a target protein. The disclosed fusion proteins include an autoproteolytic cysteine protease fused to a heterologous polypeptide, which may be isolated as the target protein. Preferably,... Agent: Northwestern University

20120295304 - Method for producing alpha-l-aspartyl-l-phenylalanine-beta-ester and method for producing alpha-l-aspartyl-l-phenylalanine-alpha-methyl ester: A method of producing an α-L-aspartyl-L-phenylalanine-β-ester by forming the α-L-aspartyl-L-phenylalanine-β-ester from L-aspartic acid-α,β-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to selectively link L-phenylalanine to an α-ester site of the L-aspartic acid-α,β-diester through a peptide bond.... Agent: Ajinomoto Co., Inc.

20120295308 - Carbohydate binding modules with reduced binding to lignin: Provided is a modified Family 1 carbohydrate binding module (CBM) comprising amino acid substitutions at one or more of positions 10, 11, 12, 14, 17, 21, 24, 29, 31, 33, and 37, said position determined from alignment of a Family 1 CBM amino acid sequence with SEQ ID NO: 30,... Agent: Iogen Enegy Corporation

20120295306 - Modified cipa gene from clostridium thermocellum for enhanced genetic stability: Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from Clostridium thermocellum is modified to generate a mutated gene with enhanced genetic stability. This mutated cipA gene can be introduced into a heterologous host, such as Thermoanaerobacterium saccharolyticum. Other cellulosome components may be introduced into... Agent: The Trustees Of Dartmouth College

20120295307 - Pichia pastoris deficient in endogenous secreted protease: The present invention relates to micro-organisms and to methods of producing proteins. More specifically, the inventions relates to a host cell useful for the expression of heterozygous proteins in which the host cell, Pichia pastoris, has been genetically modified so that the gene for endogenous secreted subtilisin Sub2 protease is... Agent: Centre Hospitalier Universitaire Vaudois (chuv)

20120295309 - Bacterial host strain comprising a mutant spr gene and having reduced tsp activity: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and... Agent: Ucb Pharma, S.a.

20120295310 - Nucleic acids encoding anti-il-23 antibodies: The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.... Agent: Zymogenetics, Inc.

20120295311 - Methods and materials for nucleic acid manipulation: The present invention is concerned with the field of nucleic acid manipulation and particularly DNA manipulation, and uses thereof. Specifically, the invention pertains to methods involving the joining of nucleic acids and uses of such joined nucleic acids, for example for creating transformed microorganisms. Also, the invention pertains to materials... Agent: Basf Se

20120295312 - Rotational pcr equipment and pcr method using the same: The rotational PCR apparatus includes: a PCR chip where PCR is performed; a rotating means connected to the PCR chip and rotating the PCR chip; and a temperature zone forming means spaced apart from the PCR chip, capable of applying thermal energy to the PCR chip and allowing the rotating... Agent: Korea Advanced Institute Of Science And Technology (kaist)

20120295313 - Process for producing granules: The present invention pertains to processes for preparing granules comprising cellulose-containing fibers and biocomposites comprising disintegrated fibers, granules and biocomposites produced by the processes of the invention, as well as uses of said granules in methods for producing biocomposites comprising disintegrated fibers.... Agent: Swetree Technologies Ab

20120295314 - Method for producing monatin: e

20120295315 - Nucleic acid encoding a cobalamin-dependent methionine synthase polypeptide: The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host... Agent:

20120295316 - Process for preparation of tacrolimus: Genetically modified strains of Streptomyces tsukubaensis (S. tsukubaensis) can be used for an improved fermentation process for the preparation of tacrolimus or a salt or derivative thereof by cultivation of these genetically modified strains. Novel genes allowing biosynthesis of allylmalonyl-CoA can be used for polyketide production with allylmalonyl extender unit.... Agent: Lek Pharmaceuticals D.d.

20120295317 - Processes and recombinant microorganisms for the production of cadaverine: The present invention relates to the use of recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine, as well as to recombinant DNA molecules and polypeptides used to produce the microorganism, said microorganism comprising an intracellular lysine decarboxylase activity and an enhanced lysine import... Agent: Basf Se

20120295318 - Cyclopropenones and the photochemical generation of cyclic alkynes therefrom: Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed... Agent: University Of George Research Foundation, Inc.

20120295320 - Apparatus and method for treatment of microorganisms during propagation, conditioning and fermentation using stabilized chlorine dioxide/sodium chlorite with hops acid extracts: A method of reducing undesirable microorganism concentration, promoting desirable microorganism propagation/conditioning, and increasing desirable microorganism efficiency in an aqueous fluid stream includes (a) introducing a quantity of fermentable carbohydrate, sugar or cellulose to an aqueous fluid stream, (b) introducing a quantity of desirable microorganism to the aqueous fluid stream, (c)... Agent: Resonant Biosciences, LLC

20120295319 - Method of modifying a yeast cell for the production of ethanol: The invention relates to a method of modifying a yeast cell for the production of ethanol. According to the invention, the activity of the Gpd1 protein and/or the Gpd2 protein is reduced.... Agent: Technische Universit&#xc4 T Berlin

20120295321 - Pentose transporters and uses thereof: The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the Aspergillus niger genes by xlnR and araR was instrumental in the identification of these... Agent: Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patient&#xeb Nzorg

20120295322 - Method of producing lycopene using recombinant esherichia coli: A method of producing lycopene, with high productivity by means of a recombinant bacterial strain includes preparing the recombinant vector containing genes encoding proteins, which are required for lycopene biosynthesis. The genes involved in lycopene biosynthesis are crtE, crtB and crtI, and at least one of the said three genes... Agent: Amicogen Co., Ltd.

20120295323 - Inactivation of proteases: The invention relates to a process for inactivating proteases by repeatedly changing the pH in the cell culture supernatant at the start of the process for the purification of biopharmaceuticals. The pH is adjusted first to 3-5, and then to 7-9.... Agent: Boehringer Ingelheim International Gmbh

20120295325 - Firefly luciferase, its gene, and method for producing firefly luciferase: A firefly luciferase having the amino acid sequence of firefly luciferase, wherein the amino acid corresponding to position 287 of Heike firefly luciferase is replaced with alanine, or wherein the amino acid corresponding to position 392 is replaced with isoleucine. The firefly luciferase has improved thermostability and storage stability. A... Agent: Kikkoman Corporation

20120295326 - Luciferases and methods for making and using the same: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides... Agent: The Regents Of The University Of California

20120295324 - Overproduction of ligninolytic enzymes: Methods, compositions, and systems for overproducing ligninolytic enzymes from the basidiomycetous fungus are described herein. As described, the method can include incubating a fungal strain of Cerrena unicolor IB303 in a fermentation system having growth medium which includes lignocellulosic material and then cultivating the fungal strain in the fermentation system... Agent: The Regents Of The University Of California

20120295327 - Targeted therapeutic proteins: Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor.... Agent: Biomarin Pharmaceutical Inc.

20120295329 - Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity: This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine hydrolases have one or more amino acid residues in a subsite replaced with a cysteine, wherein the cysteine is modified by replacing the thiol hydrogen in the... Agent: The Governing Council Of The University Of Toronto

20120295328 - Method for isolating small rna: A method for isolating small RNA from a sample is provided, the method comprising binding the RNA to silica particles by contacting the sample with a) at least one alcohol, b) at least one chaotropic salt comprising a chaotropic anion selected from the group consisting of trichloroacetate, perchlorate and trifluoroacetate... Agent: Qiagen Gmbh

20120295330 - Methods of intracellular conversion of single-chain proteins into their di-chain form: The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein... Agent: Allergan, Inc.

20120295331 - Savinase variants having an improved wash performance on egg stains: Subtilase variants having an improved wash performance on egg stains. These subtilases are useful exhibiting excellent or improved wash performance on egg stains when used in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.... Agent: Novozymes A/s

20120295332 - Systems and methods for delivering oxygen to a vessel: Oxygen is delivered into a liquid contained within a vessel. Oxygen-rich gas is introduced at an inner mixing region of a vessel toward an agitating element for dissolving some of the oxygen into the liquid. Air is introduced to the liquid at a location different from where the oxygen-rich gas... Agent:

20120295333 - Systems and methods for producing a gas dispersion in a biological substance in a disposable vessel: Biological liquid substances in a disposable bioreactor or a disposable fermentor is enriched with a dissolved gas such as oxygen. The gas is provided to the liquid in meeting growth needs of biomass within the disposable vessel. The liquid is processed through a bubble forming element such as a supersonic... Agent:

20120295334 - Method for the oxygenation of fermentations using oxygen and air or other oxygen reducing gases: An improved fermentation device and method uses a combination of substantially pure Oxygen as the Oxygenation gas and a separate air (or other Oxygen reducing gas) purge through the headspace of a fermentation device. The air injection and air purge vent line are configured to maintain a backpressure within the... Agent: Air Liquide Industrial U.s. Lp

20120295335 - Prevention of contamination of nutrient feed reservoirs & feed lines in bioreactor: A method to prevent contamination of feed line(s) and nutrient feed reservoirs(s) is disclosed. In this method the growth medium which flows from the nutrient feed reservoir through the feed line to the bioreactor contains at least one nutritional component supplied at a concentration which is inhibitory to cell growth.... Agent: E. I. Du Pont De Nemours And Company

20120295337 - Algae culture system: A microalgae culture system that provides greater control of a culture due to distribution and the shape of its components. The system allows for the possibility to incorporate gases into the medium, resulting in an increased culture yield and lower energy consumption per unit volume. The system generally includes a... Agent:

20120295336 - Microalgae cultivation system for cold climate conditions: A system and method are provided for growing microalgae in cold climate areas. The system includes an expanding Plug Flow Reactor with a plurality of ponds used to grow algae by mixing a culture fluid with a nutrient. To minimize the loss of heat due to environmental factors, the expanding... Agent:

20120295338 - Monitoring systems for biomass processing systems: A sensor array is disclosed that includes a conduit having a lumen extending between an inlet and an outlet of the conduit. The sensor array can include a plurality of sensors coupled to the conduit. Each sensor can have a probe member that is disposed within the lumen. The sensors... Agent:

20120295339 - Method and apparatus for detection, analysis, and collection of rare cellular events: Systems and methods for the detection, analysis, and collection of rare cellular events, wherein rare cellular events are defined by events comprising less than 5% of a total number of cells in a sample. The systems and methods generally include: (1) a flow cell dimensioned so as to permit a... Agent: Abbott Laboratories

20120295340 - Separation and concentration of biological cells and biological particles using a one-dimensional channel: This document discloses, among other things, a method and system for a substrate having a bypass region for fluid flow. The substrate includes a plurality of fluid flow channels with each channel configured to concurrently allow fluid flow while precluding passage of a target particle or object.... Agent: University Of Washington

20120295341 - Thermal treatment apparatus and fluid treatment method with fluidic device: A thermal treatment apparatus includes a fluidic device including at least one channel, a first temperature-changing unit that changes the temperature of a fluid in part of the channel, and a second temperature-changing unit that changes the temperature of the fluid in another part of the channel. The temperature changes... Agent: Canon Kabushiki Kaisha

20120295343 - Closure assembly for cell culture apparatus: A closure assembly for a cell culture apparatus includes a port and a snap cap. The port has an annular sidewall defining an opening in communication with a cell culture chamber of a cell culture apparatus. The sidewall has (i) external threads for cooperating with internal threads of a twist... Agent:

20120295342 - Prevention of contamination of feed reservoirs & feed lines in bioreactor systems: A method to prevent contamination of feed line(s) and nutrient feed reservoir(s) is disclosed. In this method a heated zone is established in the feed line close to the location where the feed line connects to the bioreactor. The heated zone prevents back growth of cells from the bioreactor back... Agent: E. I. Du Pont De Nemours And Company

20120295344 - Stem cell fusion model of carcinogenesis: Model systems and methods for exploring mechanisms of carcinogenesis and the acquisition of metastatic ability, and to provide insights into potential therapeutic targets. The systems include and methods involve fusion of a stem cell and a genetically altered cell to evaluate carcinogenesis and metastasis and for the discovery and evaluation... Agent: Arizona Board Of Regents On Behalf Of The University Of Arizona

20120295345 - Apparatuses and related methods for delivering biological material into a cell: Systems, devices, and methods for protecting a biological material during delivery into a biological structure are provided. In one aspect, for example, a device for protecting and delivering a preselected biological material into a biological structure can include a lance operable to maintain a charge capable of associating a biological... Agent:

20120295346 - Methods and compositions for modulating membrane potential to influence cell behavior: The present invention provides methods for controlling proliferation, differentiation, and/or migration of cells by modulating membrane potential through an endogenously expressed channel protein. The present invention also provides methods for identifying candidate instructor cells, as well as therapeutic agents that are useful for modulating (e.g., promote or inhibit) proliferation and... Agent: Tufts University

20120295347 - Methods and compositions for producing endothelial progenitor cells from pluripotent stem cells: Aspects of the present invention are drawn to methods and compositions for producing endothelial progenitor cells (EPCs) in vitro from pluripotent stem cells and compositions containing such EPCs. The methods produce sufficient EPCs to use in therapeutic applications. In certain embodiments the EPCs are bipotent, giving rise to both vascular... Agent:

20120295348 - Method for proliferating stem cells by activating c-met/hgf signaling and notch signaling: The present invention relates to stem cells in which a gene that activates signaling is introduced and to a method for proliferating the stem cells. More specifically, the invention relates to a method of significantly increasing the ability of stem cells to proliferate, either by transfecting stem cells with the... Agent: Samsung Life Public Welfare Foundation

20120295349 - Mammal dedicated cell line from human hepatocellular carcinoma cell: A mammal dedicated cell line is provided, which is a HepG2 hepatocellular carcinoma cell line (HepG2/NF-kB/Luc/sr39tk)1_18 obtained by co-transformation with NF-kB/Luc and NF-kB/sr39tk. Firstly, a successfully transformed pNF-kB/Luc HepG2 cell is obtained. Then, a dedicated cell line sensitive to TPA and MTX is generated by experimental screening Next, a plasmid... Agent: Institute Of Nuclear Energy Research Atomic Energy Council, Executive Yuan

20120295350 - Prospective identification and characterization of breast cancer stem cells: The invention provides methods for treating cancer via administering to a patient having a solid tumor a therapeutically effective amount of an antibody against Delta-like ligand 4(D114) or other Notch pathway components. The solid tumor may comprise solid tumor stem cells.... Agent: The Regents Of The University Of Michigan

20120295351 - Method for cloning pluripotent stem cells: Embodied herein are methods of reprogramming somatic cells or tissue stem cells to a more multipotent state or even a pluripotent state, the methods do not involve gene transfer of master transcription factor genes/proteins. The methods are also useful for rapid and efficient cloning of induced pluripotent stem cells after... Agent: Boston Biomedical Research Institute, Inc.

20120295352 - Systems and methods for expanding high density non-adherent cells: Embodiments described herein generally relate to systems and methods for promoting the expansion of high density non-adherent cells through the use of a cell growth chamber, a mass transfer device, and a fluid circulation loop. Improved cell growth is achieved in the cell growth chamber by using a chamber having... Agent: Terumo Bct, Inc.

20120295353 - Methods of making and using polymers and compositions: Disclosed are methods of making and using polymers compositions. The polymer compositions may have monomer/oligomer mixtures that may have at least one silicone monomer or oligomer and at least one non-silicone monomer or oligomer, at least one crosslinker, and/or at least one polymerization initiator. The polymer compositions are cured, after... Agent:

20120295354 - Sulfonylurea-responsive repressor proteins: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms... Agent: E. I. Du Pont De Nemours And Company And Pioneer Hi-bred International

20120295355 - Nucleic acid delivery using modified chitosans: The present invention is directed to the delivery of nucleic acids in a non-viral vector to cells by positively charged chitosan derivatives, including but not limited to chitosan-arginine, chitosan-lysine and chitosan-histidine.... Agent:

20120295356 - Apparatus and method for genetically transforming cells: A fluid containing cells and free genetic material is acoustically coupled to a propulsion surface of a diaphragm. A blast-receiving surface of the diaphragm is acoustically coupled to an explosion chamber in which an explosive material is disposed. An ignition system ignites the explosive material in the explosion chamber to... Agent:

  
11/15/2012 > 96 patent applications in 55 patent subcategories. recently filed with US Patent Office

20120288848 - Multi-dimensional flow pad technology for covering three-dimensional dome shaped anatomies: A three dimensional dome wrap or pad for direct patient surface tissue applications for symmetrical dome shaped anatomy and extremities is disclosed herein. The pad of the present invention comprises a system of smooth streamline mathematically configured channels throughout one or more similarly shaped panels or lobes bonded distinctively to... Agent: Traumatec, Inc.

20120288852 - Force mediated assays: A sensitive and specific method of detecting chemical species, viruses and microorganisms is presented to improve performance of molecular-recognition-based assays utilizing particles decorated with molecular recognition agents such as antibodies and DNA probes, and observing analyte-dependent changes in the response of the particles to forces such as magnetic or gravitational... Agent:

20120288851 - Measurement system, measurement method, program for implementing the method, and recording medium for the program: The invention relates to a measurement system MS1 provided with a plurality of loading units 10 into which a measurement tool 4 supporting a reagent is loaded. The measurement system MS1 includes reading means 2 for reading information on an analyte provider that includes identification information, and guidance means 11... Agent: Arkray, Inc.

20120288849 - Method and system for robust and sensitive analysis of bead-based assays: Computer-implemented methods and systems are provided for the analysis of multiplex fluorescent-dyed microsphere assays. The methods of the invention provide for determination of differences in analyte quantities between samples obtained from multiplex fluorescent-dyed microsphere assays by analysis of individual bead fluorescence and adjusting for variance; variance-stabilization of the data, and... Agent: The Board Of Trustees Of The Leland Stanford, Junior, University

20120288850 - Methods for diagnosis of immune responses against viruses: The present invention relates to methods for diagnosis of a cellular immune responses against a virus using an inactivated virus. In the method of the invention a cellular immune response against the virus is detected in a subject by incubating PBMCs from the subject with a preparation of inactivated virus... Agent: De Staat Der Nederlanden, Vert. Door De Minister Van Vws

20120288854 - Automated high-throughput seed sampler and methods of sampling, testing and bulking seeds: An automated system for sampling seeds includes a seed loading station for separating individual seeds from a plurality of seeds held in a seed hopper, an imaging station configured to receive the separated seeds from the seed loading station and collect image data of the received seeds, and a seed... Agent: Monsanto Technology LLC

20120288855 - Fluorescent chemical compounds having high selectivity for double stranded dna, and methods for their use: Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can... Agent: Life Technologies Corporation

20120288853 - Methods for operating chemically sensitive sensors with sample and hold capacitors: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and... Agent: Life Technologies Corporation

20120288858 - Assessing small cell lung cancer outcomes: This document provides methods and materials involved in assessing lung cancer (e.g., SCLC). For example, methods and materials for identifying a mammal having lung cancer (e.g., SCLC) as being susceptible to a poor outcome are provided.... Agent:

20120288864 - Detection of salmonella by real-time multiplex pcr: The invention relates to the detection of Salmonella by nucleic acid amplification. The invention provides primer and probe oligonucleotides that can be used in multiplex to detect Salmonella in real-time amplification. The oligonucleotides of the invention detect all group I serovars, and have an increased Salmonella detection range: they enable... Agent: Bio-rad Innovations

20120288860 - Differential gene expression for detecting and/or differentiating lung disease: Disclosed herein are methods, constructs, kits, and the like, which can be used for detecting and/or differentiating interstitial lung disease. For example, idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) can be detected and/or differentiated using at least one biomarker.... Agent: George Mason University

20120288861 - Germline polymorphisms in the sparc gene associated with clinical outcome in gastric cancer: This disclosure provides compositions and methods for determining the likely tumor recurrence of gastric cancer patients based on genomic polymorphisms of the SPARC gene. The disclosure also provides compositions and methods for selecting gastric cancer patients for appropriate treatments and methods of treating them.... Agent:

20120288862 - Kits for quantitative detection of k-ras mutations: The present invention relates to an assay kit for quantitatively detecting k-ras gene mutations. Particularly, the present invention relates to detection method and a detection kit for K-ras gene mutations, which relates to the therapeutic efficacy of targeted molecular anti-cancer drugs. More particularly, the present invention relates to a fluorescent... Agent:

20120288856 - Molecular sexing of avian subjects: The present invention provides oligonucleotides including amplification primers and probes as well as pairs of said oligonucleotides that are useful in methods and uses for the determination of the sex of an avian subject. Similarly, these oligonucleotides can be used for the preparation of a kit for the determination of... Agent:

20120288857 - Multifunctional probe-primers: Methods and reagents for detection and analysis of nucleic acids are provided. Certain methods involves an encoding amplification in which a target sequence is associated with probe-binding sequences and optionally with indexing sequences, (2) an optional distribution step in which the product of the encoding amplification is split into multiple... Agent: Fluidigm Corporation

20120288863 - Oligonucleotides and methods for detecting kras and pik3ca mutations: Provided are oligonucleotides that are capable of detecting KRAS and PIK3CA mutations in both cancer patients and healthy individuals with high specificity in kPCR assays. When the oligonucleotides are used as forward primers in conjunction with a defined genotyping algorithm spreadsheet, the primers are capable of enhancing detection of KRAS... Agent: Siemens Healthcare Diagnostics Inc.

20120288859 - Probe for detecting poly a repeat number polymorphism of hgf gene and uses thereof: The present disclosure relates to probes for detecting a polymorphism of HGF gene.... Agent:

20120288868 - Isolation of nucleic acids: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.... Agent: Exact Sciences Corporation

20120288865 - Method and apparatus for generating thermal melting curves in a microfluidic device: The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.... Agent: Caliper Life Sciences, Inc.

20120288869 - Modulating gene expression with agrna and gapmers targeting antisense transcripts: Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream... Agent:

20120288867 - Serial isolation of multiple dna targets from stool: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting multiple DNA targets from human stool samples.... Agent: Exact Sciences Corporation

20120288866 - Systems and methods for producing an evaporation barrier in a reaction chamber: The embodiments described herein relate to systems and methods for producing an evaporation barrier in a PCR vial. In some embodiments, beads with a particular distribution in diameters can be used to produce a barrier for reducing the evaporation of liquid PCR samples within the PCR vial. In some embodiments,... Agent: Genturadx, Inc.

20120288870 - Means for the inhibition of anti-beta1-adrenergic receptor antibodies: Embodiments of the present invention provide for novel peptides of use for detection and/or inhibition of anti-β1-adrenergic receptor antibodies. Certain embodiments concern uses of cyclic and/or linear peptides. In other embodiments, the present invention relates to novel peptides of use in diagnostic and/or pharmaceutical compositions. Some embodiments concern diagnosing and/or... Agent: Julius-maximilians-universitat Wurzburg

20120288871 - Modified carbocyanine dyes and their conjugates: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein... Agent: Life Technologies Corporation

20120288877 - Electrochemical methods of detecting colon cancer cells and use of same for diagnosing and monitoring treatment of the disease: A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cell with the substrate, so as to generate a product capable of producing an electrical signal; and (b) measuring... Agent: Ramot At Tel-aviv University Ltd.

20120288876 - Novel identified oncogene with kinase-domain (nok): A newly identified oncogene with kinase domain (NOK) and its encoded polypeptide, and vectors, fusions, host cells and transgenic animals comprising the said nucleotide sequence. Furthermore, the present invention also describes the methods for diagnosing diseases including tumor and the methods for screening agents capable of inhibiting the occurrence and/or... Agent: Tsinghua University

20120288878 - Methods for identifying immunobinders of cell-surface antigens: The invention provides methods for identifying immunobinders, such as scFv antibodies, capable of specifically binding to cell surface antigens, and compositions identified according to said methods.... Agent: Esbatech, An Alcon Biomedical Research Unit LLC

20120288873 - Biomarkers for the detection and screening of down syndrome: The disclosure includes assays and methods for screening for risk of Down syndrome and/or trisomy 21 in a fetus. The assays and methods comprise determining the level of at least one biomarker selected from mucin 13 (MUC13), bile salt-activated lipase (CEL), dipeptidyl peptidase 4 (DPP4), carboxypeptidase A1 (CPA1), amyloid precursor... Agent: University Health Network

20120288874 - Enzymatic activity-based detection: Disclosed herein are methods and kits which are useful for detecting presence of an enzyme in a test sample based upon the intrinsic enzymatic activity of such test sample. The present invention provides the ability to evaluate cell culture conditions and optimize the desired glycoform content of recombinantly prepared enzymes.... Agent:

20120288872 - Gene defects and mutant alk kinase in human solid tumors: Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion... Agent: Cell Signaling Technology, Inc.

20120288875 - Diagnostic test for the detection of a molecule or drug in whole blood: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand;... Agent: Abbott Laboratories

20120288881 - Method for evaluating the cure level of stroke: A method for evaluating the cure level of a stroke patient comprises following steps: (1) obtaining isolated blood sample from said stroke patient; (2) determining the concentration of serum granulocyte colony-stimulating factor (G-CSF) of said blood sample; (3) comparing the relationship between said concentration of granulocyte colony-stimulating factor (G-CSF) and... Agent: Changhua Christian Hospital

20120288880 - Methods and compositions for diagnosis or prognosis of cardiovascular disease: The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method comprises detecting a measurable feature of at least two biomarkers in an EMT subfraction, or in a complex containing apoA-I... Agent: Washington, University Of

20120288879 - Methods for developing and assessing therapeutic agents: Assays are provided that can effectively assess tumor response to one or more therapeutic agents. Preferred assays of the invention include assessment of posttranslation modification and expression of target proteins.... Agent: Altiok, Inc.

20120288882 - Type iv secretion system proteins in sero-detection of anaplasma phagocytophilum: Disclosed are two (2) proteins in the Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum (namely, virB 10 and virB 11) useful in the ELISA detection of Anaplasma pathogen. The recombinant expression of virB 10 and virB 11 and their use as kits for ELISA are also disclosed.... Agent: Medical Diagnostic Laboratories, LLC

20120288883 - Probe reagent for measurement of proteolytic activity: This invention relates to a probe reagent comprising, in order from the N-terminus to the C-terminus, the amino acid sequences of a fluorescent protein I, a peptide capable of terminating protein degradation (i.e., a degradation-terminating peptide), a spacer peptide, a fluorescent protein II, and a protein to be degraded, wherein... Agent: Japan Science And Technology Agency

20120288885 - Method and kit for measuring enzymatic activities of various cytochrome p450 molecule species comprehensively and with high efficiency: the cytochrome P450 generates NADPH by being irradiated with light in the presence of at least one caged compound selected from the group consisting of caged-NADP and caged-G6P, an enzyme utilizing NADPH as a coenzyme (i.e., cytochrome P450 reductase) and a substrate thereof to supply NADP and/or G6P from the... Agent: National University Corporation Kobe University

20120288884 - Quinazolinone based fluorogenic probes: The present invention relates to a compound of the general formula (I) useful in the determining the presence, amount or activity of an enzyme in living cells, a method of preparing said compounds and a kit thereof.... Agent: Nanyang Technological University

20120288887 - Blood cell agglutination image determining method and blood cell agglutination image determining apparatus: The present invention provides a blood cell agglutination image determining method and a blood cell agglutination image determining apparatus capable of processing a blood sample in a short time and obtaining a reproducible determination result. Provided are a blood cell agglutination image determining method and a blood cell agglutination image... Agent: Beckman Coulter, Inc.

20120288886 - Inhibiting binding of fgf23 to the binary fgfr-klotho complex for the treatment of hypophosphatemia: The present invention is directed to a method of treating hypophosphatemia in a subject. The present invention is also directed to a method of screening for compounds suitable for treatment of hypophosphatemia associated with elevated or normal FGF23. This method involves providing FGF23, FGFR-Klotho complex, and one or more candidate... Agent: New York University

20120288888 - Microbial detection article: The disclosure provides an article for the detection of a microorganism in a liquid sample. The article comprises a microporous membrane and a barrier layer to selectively regulate the contact between the sample and a detection reagent. A method of use is also provided.... Agent:

20120288890 - Microbial counting cell, microbe counting device using same, and microbe counting method using same: A microorganism counting cell of the present invention includes bottomed cylindrical vessel that includes upper surface opening and cylindrical retaining body disposed vertically on a bottom surface in vessel, a collecting element provided on a lower end portion of a rod-shaped cotton swab being inserted in retaining body from upper... Agent: Panasonic Corporation

20120288889 - Reagent for blood cell counting and blood analysis method: Disclosed is a novel reagent for blood cell counting and a novel blood analysis method, which enable blood cells such as leukocytes to be counted with high accuracy by dissociating platelet aggregates in capillary blood collected from a living body. The reagent for blood cell counting is used to dilute... Agent: Horiba, Ltd.

20120288891 - Production of acetyl-coenzyme a derived compounds: The present disclosure relates to the use of pantothenate compounds as a non-genetic switch for the production of heterologous acetyl-CoA derived (HACD) compounds in microbial host cells. The invention provides genetically modified microorganisms that are more stable when stored and initially cultured under reduced pantothenate concentrations, cell culture media having... Agent: Amyris, Inc.

20120288892 - Methods for producing polypeptidies in protease-deficient mutants of trichoderma: The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease... Agent: Novozymes, Inc.

20120288893 - Seed-specific expression vector and its construction methods and applications: A seed-specific expression vector and its construction methods and applications are disclosed. A fusion protein expression cassette consisting of Arachis hypogaea oleosin gene-apolipopoprotein A-IMilano (A-IM) gene driven by Brassica napus oleosin gene promoter is inserted between the HindIII and SacI sites of a plant binary expression vector pBI121, obtaining the... Agent:

20120288894 - Bacterial host strain expressing recombinant dsbc and having reduced tsp activity: The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell comprises a recombinant polynucleotide encoding DsbC and has reduced Tsp protein activity compared to a wild-type cell.... Agent: Ucb Pharma, S.a.

20120288895 - Compositions and methods for modulating hemostasis using variant forms of activated factor v: Methods for the treatment of coagulation disorders using Factor V/Va variants are provided.... Agent: The Children's Hospital Of Philadelphia

20120288896 - Nucleic acid molecules encoding anti-amyloid-beta antibodies: The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The... Agent: Ac Immune S.a.

20120288897 - Apparatus and methods for integrated sample preparation, reaction and detection: An apparatus includes a housing, a reaction vial and a transfer mechanism. The housing defines a first flow path and a second flow path. The housing has transfer port defining an opening in fluid communication with the second flow path and a volume outside of the housing. The transfer port... Agent: Genturadx, Inc.

20120288898 - Microbial production of multi-carbon chemicals and fuels from water and carbon dioxide using electric current: The invention provides systems and methods for generating organic compounds using carbon dioxide as a source of carbon and electrical current as an energy source. In one embodiment, a reaction cell is provided having a cathode electrode and an anode electrode that are connected to a source of electrical power,... Agent:

20120288899 - Continuous method of producing a mash extract: The present invention relates to a mash extract and a continuous method of producing the mash extract by decoction mashing. The method comprises: (a) mixing a first malt enzyme source with an aqueous liquid to obtain an aqueous malt enzyme suspension; (b) separately, mixing a second enzyme source with one... Agent: Heineken Supply Chain B.v.

20120288900 - Method of producing corn starch by enzymatic process: A method of producing corn starch by enzymatic process involving: soaking the corn; crushing the corn, separating and washing embryo; fine grinding; washing and drying fiber; separating and drying protein; washing, dewatering and drying the starch. An enzyme preparation is added before the step of washing, dewatering and drying the... Agent: Baiyin Sino Biotechnology Co., Ltd.

20120288903 - Increasing methionine production by overexpressing succinate dehydrogenase: The present invention relates to a process for improving the production of methionine by culturing a microorganism modified for enhancing the expression of genes involved in succinate dehydrogenase synthesis. The microorganisms were modified in a way that the methionine/carbon source yield is increased. The isolation of methionine from the fermentation... Agent: Metabolic Explorer

20120288902 - L-cysteine-producing bacterium and a method for producing l-cysteine: An L-cysteine-producing bacterium is provided, as well as a method for producing L-cysteine etc. using the bacterium by developing a novel technique for improving L-cysteine-producing ability of a bacterium. By culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and is modified so that activity of a... Agent:

20120288901 - Method of producing methionine in corynebacteria by over-expressing enzymes of the pentose phosphate pathway: The present invention relates to a method of producing methionine in Coryneform bacteria in which enzymes of the pentose phosphate pathway are over-expressed. The present invention also relates to Coryneform bacteria for producing methionine in which at least two enzymes of the pentose phosphate pathway are over-expressed.... Agent:

20120288904 - Strains and method for the production of methionine: The present invention relates to a method for the production of methionine using modified strains with attenuated transformation of threonine. This can be achieved by reducing threonine transformation into glycine, and/or by reducing its transformation to α-ketobutyrate. The invention also concerns the modified strains with attenuated transformation of threonine.... Agent: Metabolic Explorer

20120288905 - Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof: The present invention provides isolated nucleic acids comprising nucleotide sequences encoding isoprenoid modifying enzymes, as well as recombinant vectors comprising the nucleic acids. The present invention further provides genetically modified host cells comprising a subject nucleic acid or recombinant vector. The present invention further provides a transgenic plant comprising a... Agent:

20120288906 - Process for obtaining fatty acid lower alkyl esters from unrefined fats and oils: e

20120288907 - Glucose transport mutants for production of biomaterial: A method is disclosed for restoring a Glu+ phenotype to a PTS−/Glu− bacterial cell which was originally capable of utilizing a phosphotransferase transport system (PTS) for carbohydrate transport. Bacterial cells comprising the Glu+ phenotype have modified endogenous chromosomal regulatory regions which are operably linked to polynucleotides encoding galactose permeases and... Agent: Danisco US Inc.

20120288908 - Method for producing carboxylic acids having 1-3 carbon atoms from renewable resources: The invention relates to a method for producing carboxylic acids having 1-3 carbon atoms, characterized in that 2,3-butanediol and/or acetoin are reacted to form carboxylic acids having 1-3 carbon atoms.... Agent: Wacker Chemie Ag

20120288909 - Microbial production of pentanol from glucose or glycerol: The invention relates to the production of pentanol through recombinant gene expression and metabolic engineering.... Agent: Massachusetts Institute Of Technology

20120288910 - Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids: The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or... Agent: Gevo, Inc.

20120288911 - Bioreactor for engineered tissue: A system for generating a tissue construct includes a mixing chamber, a piston chamber, a reaction chamber, and a pump. The mixing chamber is configured to receive a hydrogel solution and a cell suspension solution. The piston chamber includes a first piston and is configured to receive a mixture of... Agent: Empire Technology Development LLC A Limited Liability Company

20120288912 - Synthetic microcarriers for culturing cells: A coated microcarrier for cell culture includes a microcarrier base and a polymeric coating grafted to the base via a polymerization initiator. A method for forming the coated microcarrier includes (i) conjugating a polymerization initiator to the microcarrier base to form an initiator-conjugated microcarrier base; (ii) contacting the initiator-conjugated microcarrier... Agent:

20120288913 - Novel fusion partners for the purpose of crystallizing g-protein coupled receptors: GPCR-fusion partner proteins comprising G protein coupled receptors (GPCRs) of GPCRs and fusion partners such as rubredoxin, cytochrome b562 RIL (Bril, bRIL, BRIL), T4 lysozyme C-terminal fragment (Cterm-T4L), flavodoxin, or xylanase either substituted for some or all of the third intracellular loop of the GPCR between the fifth and sixth... Agent: Receptos, Inc.

20120288914 - Crystal structure of glyphosate acetyltransferase (glyat) and methods of use: The presently disclosed subject matter provides compositions and methods for evaluating the potential of candidate polypeptides to associate with glyphosate with a higher binding affinity, higher binding specificity, or both or to have N-acetyltransferase activity with a higher catalytic rate when compared to a native glyphosate acetyltransferase (GLYAT) polypeptide through... Agent: Pioneer Hi Bred International Inc.

20120288915 - Modified nucleotide molecules of xylanase and application thereof: Modified nucleotide molecules of xylanase and the application of the nucleotide molecules in constructing recombinant vectors, host cells or producing xylanase are disclosed, wherein the nucleotide molecules contain nucleotide sequences having greater than 80% identity with nucleotide sequence shown by SEQ ID NO: 1.... Agent:

20120288916 - Immortalized avian cell lines for virus production: The present invention relates to immortalized avian cell lines suitable for production of biologicals or viruses for vaccination. In particular, the cell lines are derived from primary cells which are transformed with at least two viral or cellular genes, one of which causes cell cycle progression whereas the other interferes... Agent: Probiogen Ag

20120288917 - Algae growth system: The invention includes a bioreactor system for growing a photosynthetic culture in an aqueous liquid and harvesting the photosynthetic culture. The present invention further relates to a method for growing a photosynthetic culture in an aqueous liquid and harvesting the photosynthetic culture. The present invention further relates to a use... Agent: Algae-tech (uk) Ltd

20120288918 - Salt tolerant organisms: Disclosed herein are transformed non-vascular photosynthetic organisms that are salt tolerant, nucleotides and vectors useful in conducting such transformations, and transformed strains produced by such transformations.... Agent: Sapphire Energy, Inc.

20120288919 - Novel process for enzymatic bleaching of food products: The present invention relates to a process for the production of a food product whereby an intermediate form of said food product comprises a pigment, which process comprises adding at least one enzyme that is effective in directly converting said pigment into a form which results in increasing the whiteness... Agent: DsmIPAssets B.v.,te

20120288920 - Disposable chip-type flow cell and flow cytometer using the same: e

20120288922 - Apparatus for faciltiating evaluating migration of cells in vitro: Method and apparatus for processing a cell culture are provided. The method includes establishing a cell culture within a holding device having one or more wells, each well holding a cell culture, and including a well substrate with at least one electrode in contact with the cell culture; periodically applying... Agent: Applied Biophysics, Inc.

20120288921 - Solar powered spectral photosynthetic bioreactor system for culturing microalgae at high density: A solar powered spectral photosynthetic bioreactor system for culturing microalgae at high density, the system comprising a photobioreactor and further comprising a solar collector, optical fiber, an illuminant device within the photobioreactor, and a residual gas absorption device and culture medium separation and recovery device each connected to the photobioreactor;... Agent: Guangzhou Institute Of Energy Conversion, Chinese Academy Of Sciences

20120288924 - Cartridge for conducting a chemical reaction: A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls... Agent: Cepheid

20120288923 - Instrument and method for automatically heat-sealing a microplate: A heating device for heating a thermally fixable sealing cover disposed over the microplate adjacent the wells, a cooling device for actively cooling the microplate and a controller set up to control activity of the heating and cooling devices in a manner to heat the sealing cover so as to... Agent: Roche Molecular Systems, Inc.

20120288925 - Optical trapping particles, angular optical trap systems, methods of making, and methods of use: The present invention relates to an optical trapping particle including a birefringent crystalline particle having a body and a length extending between a first end and a second end, said particle comprising an optic axis perpendicular to the length of the body, wherein the length of the body is greater... Agent: Cornell University-cornell Center For Technology Enterprise & Commercialization (cctec)

20120288926 - Blood cell trajectory displaying device: Disclosed is a blood cell trajectory display device (1) for displaying the blood cell trajectory leading to an agglutination, that is equipped with a TV camera (3) for sequential photographing the flow of blood, a calculation unit (70) that analyzes the blood flow images obtained by the TV camera (3),... Agent: Konica Minolta Advanced Layers, Inc.

20120288927 - Biomass treatment device: A biomass treatment device (A) includes a hot compressed water reaction device (1) that hydrolyzes a biomass by passing hot compressed water to the biomass to prepare polysaccharides, and a solid-acid catalytic reaction device (2 and 3) that generates monosaccharides from the polysaccharides using a solid-acid catalyst, and the device... Agent:

20120288928 - Photobioreactor for culturing microalgae using hollow fiber membrane: Disclosed is a high-speed photobioreactor for culturing microalgae using a hollow fiber membrane. More particularly a high-speed photobioreactor for culturing microalgae using a hollow fiber membrane capable of facilitating growth of microalgae and maximizing carbon dioxide fixation by increasing the rate of carbon dioxide saturation in a culture medium. Specifically,... Agent: Hyundai Motor Company

20120288929 - Inoculating apparatus for biological samples in agar surface of petri capsules: A disposable microsyringe, whose tubular body is attached by its rear end into the front starting point of a longitudinal void of an intermediate housing, has located in the longitudinal void a moving head movable upon an axis and, which is connected to the rear end of the syringe plunger.... Agent:

20120288930 - Lipid pathway modification in oil-bearing microorganisms: The invention provides methods of modifying the lipids produced by microbial organisms through genetic engineering. The invention also provides genetically engineered microbes and methods of fermenting microbes for oil production. Also provided are oils, fuels, oleochemicals, chemical precursors, and other compounds manufactured by such modified microorganisms. Exemplary oil-bearing organisms include... Agent: Solazyme, Inc.

20120288931 - Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with rna: Disclosed are cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells (e.g., dendritic cells or macrophage) that have been loaded with RNA derived from tumors or pathogens. By administering the RNA-loaded antigen-presenting cells to a... Agent: Duke University

20120288932 - Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.... Agent: Battelle Energy Alliance, LLC

20120288935 - \"click\" nanoparticle conjugates: Modified nanoparticles are disclosed. More specifically, nanoparticles modified with an agent through a triazole linkage are disclosed. Also disclosed are methods of preparing modified nanoparticles and methods of using these modified nanoparticles.... Agent: Northwestern University

20120288934 - Device and method for treating living cells by means of a plasma: A device for treating living cells by plasmaporation contains, in addition to devices for generating plasma and generating a field, devices for mixing and transporting active substances, predominantly in the form of nano and microparticles, for affecting the metabolism of the cells.... Agent: Leibnitz-institut Fuer Plasma. Und Tech. E. V.

20120288933 - Synthetic mimics of mir-34: Embodiments concern methods and compositions involving miR-34 mimics, including miR-34a and miR-34c mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34a sequence and a complementary passenger strand. In additional embodiments, there are double-stranded RNA molecules with modified nucleotides having an... Agent:

20120288936 - Methods for reprogramming cells and uses thereof: Described herein are methods for cell dedifferentiation, transformation and eukaryotic cell reprogramming. Also descried are cells, cell lines, and tissues that can be transplanted in a patient after steps of in vitro dedifferentiation and in vitro reprogramming. In particular embodiments the cells are Stem-Like Cells (SLCs), including Neural Stem-Like Cells... Agent: New World Laboratories Inc.

20120288937 - Bioreactor for controlling cellular growth: A system includes a first chamber configured to receive a hydrogel and a scaffold comprising a cell, wherein the hydrogel is in fluid communication with the scaffold, and wherein the hydrogel includes a plurality of unidirectional pores. The system also includes a second chamber configured to receive a first fluid... Agent:

20120288938 - Self-assembling cell aggregates and methods of making engineered tissue using the same: A composition comprising a plurality of cell aggregates for use in producing engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension, extruding the resulting pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell... Agent: The Curators Of The University Of Missouri

20120288939 - Nanoparticulate cell culture surface: where (x), (y), (z), R, R′, R″, S, W, and X, are as defined herein. Methods for making the cell culture article or cell culture article and methods for performing an assay of a ligand with the article are also disclosed.... Agent:

20120288940 - Dipeptide acetylene conjugates and a method for photocleavage of double strand dna by dipeptide acetylene conjugates: Photoreactive DNA cleaving conjugate compounds are provided comprising a DNA cleaving moiety which comprises an aryl alkyne group and a polyfunctional pH-regulated DNA-binding moiety which comprises at least one or two amino groups.... Agent: The Florida State University Research Foundation, Inc.

20120288941 - Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof: Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and to its application for genome engineering and gene therapy.... Agent: Cellectis S.a.

20120288942 - Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof: Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and to its application for genome engineering and gene therapy.... Agent: Cellectis S.a.

20120288943 - Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof: Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and to its application for genome engineering and gene therapy.... Agent: Cellectis S.a.

  
11/08/2012 > 111 patent applications in 55 patent subcategories. recently filed with US Patent Office

20120282591 - Compositions and methods for tissue preservation: Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.... Agent: President And Fellows Of Harvard College

20120282592 - Biomarker of depression, method for measuring biomarker of depression, computer program, and recording medium: Provided is a method for using low molecular weight compounds found in the body as a biomarker for diagnosing depression. Specifically, more than one compound selected from a group comprising the following are used: ADP-ribose, ATP, ADP, AMP, serotonin, tryptophan, kynurenine, SDMA (symmetrical dimethylarginine), threonine, glyceric acid, serine, N-acetylaspartic acid,... Agent: Human Metabolome Technologies Inc.

20120282595 - High throughput cell-based hpv immunoassays for diagnosis and screening of hpv-associated cancers: Methods for quantifying an HPV protein expression in a clinical sample are disclosed. The quantifying methods include the process for obtaining the clinical sample. Such a clinical sample is consisted of a population of cells that are susceptible to infection by an HPV. The quantifying methods also include the process... Agent:

20120282593 - Method and kit for detecting virulent strains of influenza virus: The present invention is a kit and method for determining the virulence of an influenza virus based upon the presence or absence of leucine at position 62, arginine at position 75, arginine at position 79 and leucine at position 82 of the polymerase basic 1-F2 protein amino acid sequence.... Agent: St. Jude Children's Research Hospital

20120282594 - Method of enhanced detection for nanomaterial-based molecular sensors: Sensors based on single-walled carbon nanotubes and graphene which demonstrate extreme sensitivity as reflected in their electrical conductivity to gaseous molecules, such as NO, NO2 and NH3, when exposed to in situ ultraviolet (UV) illumination during measurement of the analytes are disclosed. The sensors are capable of detection limits of... Agent: Honda Motor Co., Ltd.

20120282596 - Sensor for biomolecules: A method for sensing biomolecules in an electrolyte includes exposing a gate dielectric surface of a sensor comprising a silicon fin to the electrolyte, wherein the gate dielectric surface comprises a dielectric material and antibodies configured to bind with the biomolecules; applying a gate voltage to an electrode immersed in... Agent: International Business Machines Corporation

20120282603 - Automated system for isolating, amplifying and detecting a target nucleic acid sequence: A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively compliant articulated robot arm (SCARA). This synergistic integration of previously separate diagnostic tools creates a system and method whereby a minimum of... Agent:

20120282600 - Basophil analysis system and method: Provided herein are systems and methods for analyzing blood samples, and more specifically for performing a basophil analysis. In one embodiment, the systems and methods include: (a) staining a blood sample with an exclusive cell membrane permeable fluorescent dye; and then (b) using measurements of light scatter and fluorescence emission... Agent: Abbott Laboratories

20120282597 - Biomarker and method for evaluating risk of proliferation, invasion, or metastasis of cancer: The present invention relates to a biomarker associated with a cancer and a method using the biomarker to evaluate a risk of proliferation, invasion, or metastasis of a cancer. The method of the present invention comprises the following steps: (A) providing a tissue sample to evaluate for risk of proliferation,... Agent: National Cheng Kung University

20120282601 - Blood analyzer, blood analysis method, and computer program product: A blood analyzer, a blood analysis method, and a computer program product that can distinguishably detect abnormal lymphocytes, blasts, and atypical lymphocytes are provided. A blood analyzer prepares a first measurement sample from a first reagent containing a hemolyzing agent, a second reagent containing a fluorescence staining dye, and the... Agent:

20120282602 - Multiple- analyte assay device and system: Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including... Agent: Ibis Biosciences, Inc.

20120282599 - Nucleated red blood cell analysis system and method: Systems and methods for analyzing blood samples, and more specifically for performing a nucleated red blood cell (nRBC) analysis. The systems and methods screen a blood sample by means of fluorescence staining and a fluorescence triggering strategy, to identify nuclei-containing particles within the blood sample. As such, interference from unlysed... Agent: Abbott Laboratories

20120282598 - White blood cell analysis system and method: Systems and methods for analyzing blood samples, and more specifically for performing a white blood cell (WBC) differential analysis. The systems and methods screen WBCs by means of fluorescence staining and a fluorescence triggering strategy. As such, interference from unlysed red blood cells (RBCs) and fragments of lysed RBCs is... Agent: Abbott Laboratories

20120282604 - Copy number variation determination, methods and systems: The present invention methods and systems for determining copy number variation of a target polynucleotide in a genome of a subject including amplification based techniques. Methods can include pre-amplification of the sample followed by distribution of sample and a plurality of reaction volumes, quantitative detection of a target polynucleotide and... Agent: Fluidigm Corporation

20120282609 - Gene mutation detection probe: A gene mutation detection probe for detection of a target gene mutation in a base sequence encoding a gene of interest that includes the target gene mutation and a non-target gene mutation, the probe including at least one oligonucleotide selected from the group consisting of oligonucleotides P1, P1-1, P1′, and... Agent:

20120282612 - Method for analyzing psa, and a method for distinguishing prostate cancer from prostatic hypertrophy using that method for analyzing psa: An object of the present invention can be solved by being brought into contact a lectin having an affinity for β-N-acetylgalactosamine residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for the lectin. A method for distinguishing prostate cancer from prostatic hypertrophy can... Agent: Tokyo Institute Of Technology

20120282606 - Method, kits and reaction mixtures for high resolution melt genotyping: Various methods are described that provide for high resolution melt (HRM) genotyping. Some embodiments comprise providing a locus specific primer, and two allele specific primers each comprising at least one single nucleotide polymorphism (SNP) allele-hybridizable sequence, wherein at least one of the allele specific primers also comprises at least one... Agent: Life Technologies Corporation

20120282613 - Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies: The invention provides methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies. A large panel of differentially methylated regions (DMRs) have been identified. Certain of these DMRs are hypomethylated in adult female blood DNA and hypermethylated in fetal DNA, whereas others are hypermethylated in adult female blood DNA and... Agent: Nipd Genetics Ltd

20120282614 - Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders: The invention provides methods, nucleic acids and kits for detecting metastasis of colon cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of metastasis of colon cell proliferative disorders, thereby enabling the improved diagnosis and treatment of patients.... Agent:

20120282615 - Methods of screening for compounds for use as modulators of left-right asymmetry in scoliotic subjects and for monitoring efficacy of an orthopaedic device: A method of screening for a compound for treating or preventing adolescent idiopathic scoliosis (AIS), said method comprising: (a) contacting a test compound with a paraspinal skin fibroblast or a paraspinal muscle cell sample from the right and/or left side of the spine of a subject; and (b) determining at... Agent:

20120282611 - Methods, kits and reaction mixtures for analyzing single-stranded nucleic acid sequences: Provided herein are fluorescence detection methods for nucleic acid sequences and to kits for performing such methods.... Agent: Brandeis University

20120282610 - Oligonucleotides for detection test of polymorphism of egfr exon 19 and use thereof: An oligonucleotide for a detection test of a polymorphism of EGFR exon 19, the oligonucleotide being at least one selected from the group consisting of a P1 oligonucleotide and a P1′ oligonucleotide, the P1 oligonucleotide having a 3′ end subjected to an extension inhibition treatment, which has an identity of... Agent:

20120282608 - Probe, polymorphism detection method, method of evaluating drug efficacy or tolerance, and reagent kit: A probe for detecting polymorphism in the ABCC2 gene is constituted by including, for example, an oligonucleotide which is complementary to a base sequence including the 207th to the 217th bases of the base sequence indicated in SEQ ID NO:1 and having a length of from 11 bases to 60... Agent:

20120282607 - Probe, polymorphism detection method, method of evaluating drug efficacy or tolerance, disease prediction method and reagent kit: A probe for detecting polymorphism in the ABCG2 gene is constituted by including, for example, an oligonucleotide which is complementary to a base sequence including the 301st to the 311th bases of the base sequence indicated in SEQ ID NO:1 and having a length of from 11 bases to 50... Agent:

20120282605 - Process controls for molecular assay: A full process control for use with a molecular assay and a method of determine the efficacy of the molecular assay. A full process control can include a fixed cell, and specifically can include a fixed vegetative cell. A method of determining the efficacy of a molecular assay can include... Agent: Geneohm Sciences, Inc.

20120282617 - Detection using a dye and a dye modifier: The present invention relates to dyes in general. The present invention provides a wide range of dyes and kits containing the same, which are applicable for labeling a variety of biomolecules such as nucleic acids, cells and microorganisms. The present invention also provides various methods of using the dyes for... Agent: Biotium, Inc.

20120282619 - Method for screening anti-cancer compounds inhibiting function of tm4sf5 and anti-cancer composition containing chalcone compounds: The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as... Agent: Seoul National University Industry Foundation

20120282620 - Method of manufacturing reference material using plant cultured cell lines: A method of manufacturing a reference material for determining incorporation of a genetically modified (GM) plant into a sample or analyzing a mixing ratio from a tissue-cultured cell line that is obtained by incubating tissues of either a GM plant or a non-GM plant, and a method of determining incorporation... Agent: Korea Research Institute Of Standards And Science

20120282618 - Methods and assays for risk prediction, diagnosis, and analysis of myocardial infarction, heart failure and reduced cardiac function: Methods and kits adapted for risk prediction, diagnosis, and analysis of myocardial infarction (MI), myocardial failure, and reduced cardiac function such as heart failure. The methods include collecting a sample of human body fluid or tissue from a subject and then identifying the presence of cardiac myosin binding protein-C 25-nucleotide... Agent: Loyola University Chicago

20120282621 - Methods and compositions for assessment of pulmonary function and disorders: The present invention provides methods for the assessment of risk of developing chronic obstructive pulmonary disease (COPD), emphysema or both COPD and emphysema in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing... Agent: Synergenz Bioscience Limited

20120282622 - Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind... Agent: The Regents Of The University Of California

20120282623 - Rapid pathogen detection techniques and apparatus: Methods for selectively detecting a live pathogen in a sample containing live and dead pathogens, without detecting the dead pathogen are disclosed. Such methods may include: (i) immobilizing at least a portion of the live and dead pathogens on a solid support with a physical barrier; (ii) incubating the solid... Agent: Hitachi Chemical Co., Ltd.

20120282616 - Treatment of a sample with focused acoustic energy: A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision... Agent: Biocartis Sa

20120282624 - Integration of genes into the chromosome of saccharopolyspora spinosa: This invention includes a process for the identification and validation of a neutral polynucleotide integration site within the S. spinosa genome. In addition, the invention includes the use of the neutral site and methods for the integration of a polynucleotide containing a gene expression cassette, which is stably maintained and... Agent: Dow Agrosciences LLC

20120282625 - Microfluidic device comprising microchannel where protrusions are formed on bottom surface: Disclosed is a microfluidic device comprising a microchannel through which fluid can flow. Protrusions are formed on the bottom surface of the microchannel. The microfluidic device increases detection sensitivity by improving optical characteristics and enhances the reactivity of biochemical reaction by slowing down the velocity of fluid flowing inside the... Agent: Nanoentek, Inc.

20120282626 - Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells: This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.... Agent: The Scripps Research Institute

20120282633 - Antibody specific to activated egfr: Disclosed is a means for accurately measuring activated EGFR regardless of whether phosphorylation has occurred or not. The antibody or antigen-binding fragment thereof according to the present invention can bind to activated EGFR regardless of whether the activated EGFR is in a phosphorylated form or in a nonphosphorylated form. By... Agent:

20120282632 - Functionalized chromophoric polymer dots and bioconjugates thereof: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed.... Agent: Clemson University

20120282631 - Method for diagnosis non-small-cell-lung-carcinoma (nsclc) and classification of its subtypes with different combinations of 6 protein biomarkers: A method of identifying and classifying non-small-cell lung carcinoma in a biological sample includes a first test wherein the expression level of at least one biomarker is measured in a sample, the at least one=biomarker is selected from a first group consisting of chaperonin, 2,3-bisphosphoglycerate mutase, thymidine phosphorylase, and minichromosome... Agent: The Hong Kong Polytechnic University

20120282634 - Blood separation system and method for a dry test strip: A dry test strip layer for filtering red blood cells includes a Borosilicate Glass Fiber layer and lectin, impregnated in the borosilicate layer, such that the dry test strip is configured to filter red blood cells from a blood sample.... Agent: Polymer Technology Systems, Inc.

20120282635 - Self-calibrating gradient dilution in a constitutent assay and gradient dilution apparatus performed in a thin film sample: A method and apparatus for measuring antibody titers in a thin film sample in an automated system which does not require multiple dilutions. The system provides a simple method for creating an in-situ dilution within a sample analysis chamber without the use of any precision fluid-handling components, and further, to... Agent: Abbott Point Of Care, Inc.

20120282627 - Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase: The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders.... Agent:

20120282628 - Method for diagnosing cancer using lectin: The present invention relates to a method for diagnosing cancer using information on aberrant glycosylation of glycoproteins, which is related with cancer progression. More particularly, the present invention relates to a peptide marker for cancer diagnosis and a method for diagnosing cancer using the peptide marker, wherein glycoproteins aberrantly glycosylated... Agent: Korea Basic Science Institute

20120282629 - Enhancers of protein degradation: The present invention relates to compounds suitable for modulating huntingtin protein processing and useful for treating or preventing huntingtin-related disorders. The invention provides pharmaceutical compositions comprising said compounds and methods of syntheses thereof.... Agent: Max-delbruck-centrum Fur Molekulare Medizin

20120282630 - Mixed-metal substrates for metal-enhanced fluorescence: The present invention provides for mixed metal structures that can be deposited on a substrate or free in solution that exhibit several distinctive properties including a broad wavelength range for enhancing fluorescence signatures. Further, metal surface plasmons can couple and such diphase coupled luminescence signatures create extra plasmon absorption bands.... Agent:

20120282636 - Diagnostic device: The invention provides for rapid response analysis through lateral flow chromatographic assays of specific antigens present in human or animal fluids, or in agricultural, microbial or biological products, with an audio and visual result of the analysis and when needed, an electronic surge to provide heat for rapid results. A... Agent: Pop Test, LLC

20120282638 - Method for immunoassay of autoantibody against ku86, kit for use in same, and method for determination of primary hepatocellular carcinoma using same: An autoantibody against Ku86 can be measured by reacting the autoantibody contained in a sample with a Ku86 antigen (which serves as a reagent) to produce an immune complex of the autoantibody and the Ku86 antigen and measuring the immune complex using a labeled anti-human immunoglobulin antibody. The measurement of... Agent:

20120282637 - Polypeptides for binding to the receptor for advanced glycation endproducts as well as compositions and methods involving: The present invention relates to a polypeptide or polypeptide complex comprising at least the two amino acid sequences arranged to allow for specific binding to the “receptor for advanced glycation endproducts” (RAGE), one or more nucleic acid(s) coding for the polypeptide or polypeptide complex, a cell producing an antibody against... Agent: Sanofi

20120282639 - Light collection system: The present teachings provide a detection cell for a biological material and methods for detecting biological material including a photosensitive material optically coupled to an interior volume containing the biological material so to avoid optical components or an external light source.... Agent: Life Technologies Corporation

20120282641 - Method of identifying peptides: Methods of identifying polypeptides have been developed using a de novo sequencing technique. Methods use photodissociation and low-energy fragmentation and the spectra of peptide ions obtained therefrom, such as obtained by post-source decay (PSD), have been developed. The methods include photodissociation and the spectra therefrom obtainable from treating ions with... Agent: Indiana University Research And Technology Corporation

20120282642 - Methods for measuring the metabolism of neurally derived biomolecules in vivo: The present invention relates to methods of diagnosing, monitoring, and assessing treatment effects for neurological and neurodegenerative diseases and disorders, such as Alzheimer's Disease, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms. Methods of measuring the in vivo metabolism of... Agent: The Washington University

20120282640 - Methods of measuring cell viability in tissue engineered products: This invention provides methods of measuring the viability of cultured cells by detecting one or more cell death-stable proteins or enzyme activities. Methods provided by the invention correlate viability to relative levels of enzyme activity in cell-containing and non-cell-containing fractions of a cell culture.... Agent: Genzyme Corporation

20120282647 - Assay for quantifying clostridial neurotoxin: i

20120282643 - Cyan and yellow fluorescent color variants of split gfp: Disclosed herein are Split-Fluorescent proteins (SFPs) including Split-Yellow Fluorescent Proteins and Split-Cyan Fluorescent proteins. Further disclosed are methods of using SFPs. For example, methods of identifying the subcellular localization of a protein and methods of identifying the membrane topology of a membrane protein are disclosed herein.... Agent: Los Alamos National Security, LLC

20120282648 - Method and system for detecting and grading prostate cancer: A method of analyzing a plurality of biopsy cores extracted from a plurality of respective biopsy locations in a prostate is disclosed. The method comprises: measuring a level of a chemical element in each of the biopsy cores, and generating a chemical element map of at least a portion of... Agent: Yeda Research And Development Co., Ltd.

20120282646 - Method for activating a natural killer cell by adjusting the expression of the socs2 gene: The present invention relates to a method for activating natural killer cells (NK cells), and more particularly, to a method for enhancing the cytotoxicity of natural killer cells by inducing the overexpression of suppressor of cytokine signaling 2 (SOCS2) which is a protein involved in cell-signaling pathways in natural killer... Agent: Korea Research Institute Of Bioscience And Biotechnology

20120282644 - Multiple-electrode and metal-coated probes: Provided are probes featuring multiple electrodes, which probes have diameters in the nanometer range and may be inserted into cells or other subjects so as to monitor an electrical characteristic of the subject. The probes may also include a conductive coating on at least one probe element to improve the... Agent: The Trustees Of The University Of Pennsylvania

20120282645 - Nanoparticles: Nanoparticles, compositions comprising the nanoparticles, and methods for manufacture and uses thereof are provided. In at least one specific embodiment, the nanoparticle can include at least one isotopically enriched metal oxide. The isotopically enriched metal oxide can be copper or zinc.... Agent: Natural History Museum

20120282649 - Fluorescence detecting apparatus, fluorescence detecting method, and fluorescence signal processing method: Disclosed herein is a fluorescence detecting apparatus. The fluorescence detecting apparatus includes a light-receiving element that receives fluorescence emitted from an object to be measured irradiated with laser light modulated at a predetermined frequency and outputs a fluorescence signal at an adjusted output level; a signal processing unit that mixes... Agent: Mitsui Engineering & Shipbuilding Co., Ltd.

20120282650 - Composite material: A composite material includes a body and a plurality of nano-scale probes. The body is made of a polymer. The plurality of nano-scale probes is embedded in the body. The nano-scale probes are substantially uniformly distributed in the polymer matrix. The nano-scale probes are nanowires, nano-particles or nanotubes... Agent: Tsinghua University

20120282651 - System and method of co-cultivating microalgae with fungus: c

20120282652 - Preparation of peptide mixtures by protease catalysis designed to provide useful biological and physical properties: A process for preparing unique peptide mixtures with a broad range of uses using combinations of natural and non-natural amino acid alkyl ester monomers and specific combinations of these monomers as dimers, trimers and higher oligomers selected from the large group of structural motifs that lead to useful physical and/or... Agent: Polytechnic Institute Of New York University

20120282653 - Method for making polypeptides: The invention provides an improved method for producing polypeptides with a C-terminal glycine in a yeast transformant being characterized in having a non functional KEX1 gene. The method is in particular well suited to produce polypeptides with an aromatic amino acid residue attached to the C-terminal glycine. The yeast strain... Agent: Novo Nordisk A/s

20120282654 - Antibody purification: The present invention provides, in part, a multi-step process for purifying antibodies including chromatographic purification and filter purification.... Agent: Schering Corporation

20120282655 - Enhanced soluble c5 saccharide yields: Methods are disclosed for increasing the level of soluble C5 saccharides produced from lignocellulosic biomass comprising acidifying fractionated lignocellulosic biomass to prevent the recondensation of soluble C5 saccharides, including C5 oligosaccharides and xylose and arabinose monomers, to insoluble higher molecular weight C5 oligosaccharides.... Agent: Renmatix, Inc.

20120282656 - Multistage fractionation process for recalcitrant c5 oligosaccharides: Methods are disclosed for increasing the level of C5 monosaccharides produced from lignocellulosic biomass using a multistage fractionation process to handle recalcitrant C5 oligosaccharides without producing unwanted degradation products. Methods for reducing C5 monosaccharides degradation products produced from lignocellulosic biomass are also disclosed. In addition, compositions and products produced by... Agent: Renmatix, Inc.

20120282657 - Enhancing spinosyn production with oxygen binding proteins: The invention describes the integration of polynucleotides into chromosomal DNA of S. spinosa species, which are useful for the production of insecticides, integrants thereof, and also to the use of the integrants. The invention includes the stable integration and expression of an oxygen-binding protein, VHb, which results in increased spinosyn... Agent: Dow Agrosciences LLC

20120282658 - Alpha-amylase variants and polynucleotides encoding same: The present invention relates to variants of a parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes.... Agent: Novozymes A/s

20120282659 - Novel beta-galactoside-alpha2,6-sialyltransferase, a gene encoding thereof, and a method for enhancing enzyme activity: The present invention provides an extremely useful and novel β-galactoside-α2,6-sialyltransferase having an optimum reaction pH in a neutral to alkaline range, and a nucleic acid encoding the sialyltransferase. The present invention further provides a vector carrying a nucleic acid encoding the sialyltransferase, and a host cell transformed with the vector,... Agent:

20120282660 - Novel method for processing lignocellulose containing material: With such a process it is possible to disintegrate or make more accessible for subsequent treatments the lignocellulose from lignocellulose containing materials, like wood or other plant material, chitin from exoskeletons from Crustacea like crabs and shrimps, and proteins such as keratin from pig hair or chicken feather, for further... Agent: Nederlandse Organisatie Voor Toegepast-natuurwetenschappelijk Onderzoek Tno

20120282661 - Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid: The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing... Agent: Genomatica, Inc.

20120282662 - Methods of and systems for producing diesel blend stocks: A method for producing biofuels is provided. A method of making biofuels includes dewatering substantially intact algal cells to make an algal biomass, extracting neutral lipids from the algal biomass, and esterifying the neutral lipids with a catalyst in the presence of an alcohol. The method also includes separating a... Agent: Heliae Development, LLC

20120282663 - Methods and compositions for producing fatty alcohols and fatty aldehydes: Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.... Agent: Ls9, Inc.

20120282665 - Method and apparatus for bio-fuel seeding: A method and apparatus is provided for microbial seeding and amendment of traditional alternative fuels production systems and processes using immobilized microbe bioreactors. The system addition utilizes attachment of yeast or other microbial consortia to a substrate to enhance alternative fuels production in fermentation processes. The system allows for the... Agent:

20120282664 - Process for production of ethanol from biomass: An object of the present invention is to provide a method for producing ethanol efficiently even in the presence of a fermentation inhibitor in a saccharified biomass. The present invention provides a method for producing ethanol from biomass, comprising: culturing a transformed xylose-utilizing yeast to overexpress the gene for at... Agent:

20120282666 - Method for producing ethanol: The present invention provides a method for producing ethanol, including: subjecting a cellulose-based material to a hot-water treatment and an ammonia treatment to obtain a fermentation substrate; and reacting the fermentation substrate with a yeast to produce ethanol. The present invention also provides a method for producing a fermentation substrate... Agent:

20120282667 - Method for positioning biological samples in a microscopic arrangement: The invention relates to methods for positioning at least one preferably biological specimen in the specimen space of a microscope arrangement, and to devices for carrying out these methods. Methods and devices arc proposed, wherein the specimen's orientation relative to a detection objective's optical axis can be repeatedly changed and,... Agent:

20120282668 - Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel sythetases molecules, methods... Agent: The Scripps Research Institute

20120282670 - Compositions and methods for enhancing production of a biological product: Provided herein are methods, nucleic acids, polypeptides, compositions, and kits relating to the conjugation of a heterologous polypeptide to a molecule of interest during production of the polypeptide in cell culture. In various embodiments, the heterologous polypeptide is linked to a sortase ligation sequence and the molecule of interest is... Agent: Alnylam Pharmaceuticals, Inc.

20120282671 - Multi-arm polyethylene glycol derivatives, conjugates and gels of pharmaceuticals and the same: A multi-arm polyethylene glycol (I) having different kinds of reactive groups and the uses thereof are disclosed, which is formed by polymerizing ethylene oxide with oligo-pentaerythritol as an initiator, wherein, PEG is same or different and is —(CH2CH2O)m-, the average value of m is an integer of 2-250; I is... Agent: Jenkem Technology Co. Ltd., Tianjin Branch

20120282669 - Solubilized phospholipids for stabilizing nucleic acid polymerases: Compositions and methods are provided that relate to solubilized phospholipids and their use in stabilizing nucleic acid polymerases. For example, a phospholipid with a tail containing at least 8 carbons can be solubilized in the presence of an amphipathic molecule.... Agent: New England Biolabs, Inc.

20120282672 - Alpha-amylase mutants: The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to the parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+... Agent: Novozymes A/s

20120282673 - Functional mutation in respiratory syncytial virus: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins... Agent: Medlmmune, LLC

20120282674 - Method for the preparation of an influenza virus: The present invention relates to a method for the preparation of a pharmaceutical composition for the prevention or/and treatment of an influenza virus infection.... Agent: Maxplanck-gesellschaft Zur Forderung Der Wissenschaften E.v.

20120282675 - Novel lactobacillus plantarum and composition containing same: The present invention provides Lactobacillus plantarum CJLP55 KCTC 11401BP, a composition for treating bowel disease containing the lactobacillus, and a composition for immunological enhancement containing the lactobacillus.... Agent:

20120282676 - Compositions and methods for enhancing lipid production in marine microalgae: Methods for enhancing lipid production and growth rate of marine algae are provided.... Agent: Old Queens

20120282678 - Method for recovering inert or living microparticles and use and installation of same: A method for recovering inert or living microparticles in which a rising liquid column is set up under negative pressure of an aqueous effluent that includes inert or living microparticles, and a foam is separated at the top of the column into a multiphase effluent enriched with inert or living... Agent: Institut National Des Sciences Appliquees

20120282679 - Methods of and systems for dewatering algae and recycling water therefrom: A method of dewatering algae and recycling water therefrom is presented. A method of dewatering a wet algal cell culture includes removing liquid from an algal cell culture to obtain a wet algal biomass having a lower liquid content than the algal cell culture. At least a portion of the... Agent: Heliae Development, LLC

20120282677 - Photobioreactor comprising rotationally oscillating light sources: m

20120282680 - Further improved blasting method: The present invention relates to a method of deactivating an explosive composition in order to render the composition safe. The present invention also relates to a cartridge that contains an explosive composition and that is adapted to achieve deactivation of the explosive composition in the event that it is not... Agent: Orica Explosives Technology Pty Ltd

20120282684 - Automated analyzer for clinical laboratory: A laboratory automation system that is capable of carrying out clinical chemistry assays, immunoassays, amplification of nucleic acid assays, and any combination of the foregoing, said laboratory automation system employing at least one of micro-well plates and deep multi-well plates as reaction vessels. The use of micro-well plates as reaction... Agent:

20120282682 - Micro-channel structure method and apparatus: A method is provided of forming a micro-channel structure for use in a biosensing device. A master structure is provided having a first configuration of micro-channels with respective first fluid flow characteristics. One or more regions of material are deposited onto the master structure using a fluidjet process so as... Agent: Ffei Limited

20120282681 - Rapid identification of organisms in bodily fluids: There is provided a device that retains a collected sample for on-demand testing of a small portion of the collected sample while the rest of the sample remains for optional additional analysis. The on-demand test provides relatively immediate information about aspects of the sample, e.g. presence of microbes, chemistry, nutritional... Agent:

20120282683 - Sample analysis device: Disclosed is a sample analysis device provided with: a first sample processing portion which is disposed in a first layer and performs some of a plurality of processes on a sample in a container; a second sample processing portion which is disposed in a second layer located above or under... Agent:

20120282685 - Expression vector suitable for expression of a coding sequence for gene therapy: Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used... Agent: Mogam Biotechnology Research Institute

20120282686 - Expression vector suitable for expression of a coding sequence for gene therapy: Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used... Agent: Mogam Biotechnology Research Institute

20120282687 - Expression vector suitable for expression of a coding sequence for gene therapy: Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used... Agent: Mogam Biotechnology Research Institute

20120282688 - Reactor systems: This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.... Agent: Abec, Inc.

20120282689 - Expanding the eukaryotic genetic code: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic... Agent: The Scripps Research Institute

20120282690 - Atmosphere control composition: The atmosphere control composition according to the present invention is an atmosphere control composition for use in the culture of cells, which comprises (a) an ascorbic acid component, (b) water, (c) a porous carrier, (d) an aldehyde-removing agent, (e) a transition metal catalyst and/or an alkaline earth metal hydroxide, wherein... Agent: Mitsubishi Gas Chemical Company, Inc.

20120282691 - Extracellular matrix coated surface for culturing cells: A cell culture product is provided for propagating embryonic stem cells, and maintaining their self-renewal and pluripotency characteristics for extended periods of time in culture. The cell culturing product includes a substrate; and a coating thereon deposited from a coating solution. The coating solution includes a mixture of extracellular matrix... Agent: Becton Dickinson And Company

20120282692 - Oocytes derived from ovarian culture initially containing no oocytes: Ovarian germ-line-competent embryonic stem cells (GLC-ESC) are cultured, either in the presence or absence of a compound having estrogenic activity. The GLC-ESC are either collected prior to specific commitment or are permitted to remain in the culture medium for a time sufficient to develop into oocytes, and the oocytes may... Agent: Ovacyte LLC

20120282693 - Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts: This invention provides methods of generating natural killer (NK) cells and dendritic cells (DCs). The methods utilize human hemangioblasts as intermediate cells to generate the NK cells and DCs. In various embodiments, the methods do not require the use of stromal feeder layers.... Agent: Stem Cell & Regenerative Medicine International, Inc.

20120282694 - Methods for the isolation and expansion of cord blood derived t regulatory cells: The present invention encompasses methods, and kits for the isolation and expansion of T regulatory cells having the CD45RA+ phenotype, including such cells from human umbilical cord blood.... Agent: The Trustees Of The University Of Pennsylvania

20120282695 - Constructs for enhancement of gene expression in muscle: Efficient and muscle-specific gene expression can be obtained with constructs containing two or more copies of USE and/or ΔUSE fused to the minimal promoter of the TnISlow gene. USE is a small (about 160-bp) upstream enhancer of the TnISlow gene that confers slow-twitch muscle fiber specificity. ΔUSE is generated from... Agent:

20120282696 - Functions and targets of let-7 micro rnas: The present invention concerns methods and compositions for treating or assessing treatment of diseases related to mis-expression of genes or genetic pathways that can be modulated by let-7. Methods may include evaluating patients for genes or genetic pathways modulated by let-7, and/or using an expression profile to assess the condition... Agent:

20120282697 - Synthetic composition and coating for cell culture: A composition for forming a polymeric cell culture surface includes (i) a pre-polymer comprising a polymer backbone, a cationic moiety conjugated to the backbone, and a cross-linker moiety conjugated to the backbone; and (ii) a peptide-polymer comprising a polymer backbone and cell adhesive peptide conjugated to the backbone. Cross-linked coatings... Agent:

20120282698 - Method for homologous recombination in eukaryotic cells: A method to construct eukaryotic cells having a target sequence in a chromosomal DNA sequence replaced by a desired replacement sequence is disclosed.... Agent: DsmIPAssets B.v.

20120282699 - Mutagenesis method using polyethylene glycol mediated introduction of mutagenic nucleobases into plant protoplasts: Method for targeted alteration of a duplex acceptor DNA sequence in a plant cell protoplast, comprising combining the duplex acceptor DNA sequence with a donor mutagenic nucleobase, wherein the duplex acceptor DNA sequence contains a first DNA sequence and a second DNA sequence which is the complement of the first... Agent: Keygene N.v.

20120282701 - Dna promoters and antrhax vaccines: The invention is related to intracellularly induced bacterial DNA promoters and vaccines against Bacillus anthracis.... Agent: Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services

20120282700 - Modified food grade microorganism for treatment of inflammatory bowel disease: The present invention relates to microorganisms that express, or have attached to their surface, a TNFα binding polypeptide. Peptides expressed or attached on the surface of microorganism are more resistant to chemical and enzymatic degradation in the gastrointestinal tract. Such microorganisms are capable of binding TNFα and therefore reducing the... Agent: Institute Jozef Stefan

  
11/01/2012 > 123 patent applications in 72 patent subcategories. recently filed with US Patent Office

20120276518 - Method and device for perfusing tissue by exvivo attachment to a living organism: P

20120276519 - Cannula: Disclosed is a cannula including a first clamping portion, a second clamping portion and a force applying portion configured to apply at least two different clamping forces across the first clamping portion and the second clamping portion when the cannula is in a closed state. The first clamping portion includes... Agent: Lifeline Scientific, Inc.

20120276520 - Assay for mutations in stem cells and their derivatives: The present invention provides methods to assess the genetic safety of stem cells, whether endogenous embryonic stem cells, somatic or adult stem cells, or artificially induced stem cells from non-pluripotent cells, and their differentiated derivatives for use in human medicine, and the applications of modified stem cells to testing environmental... Agent: The Board Of Regents Of The University Of Texas System

20120276524 - Genotyping method: The present invention relates to a genotyping method, and more particularly to an ID sequence, which is assigned to each genotype, and a multiplex genotyping method which uses the ID sequence. When pyrosequencing is performed using the ID sequence, a unique and simple pyrogram can be obtained for each genotype.... Agent: Genomictree, Inc.

20120276523 - Liquid drop diagnostic assays: The present invention provides simple and inexpensive assays for the detection of virtually any analyte in any sample that is in liquid form or that can be solubilized. The assays utilize the fluid dynamics of drop evaporation whereby soluble materials, including analytes and particles binding thereto, are drawn to the... Agent: Vanderbilt University

20120276526 - Method and system for monitoring and recording viral infection process and screening for agents that inhibit virus infection: The present invention relates to a method for monitoring and recording a viral infection process, which is characterized by providing a microcantilever detection device, which comprises a microcantilever comprising a contact area having an macromolecular material attached thereon; loading host cells to the contact area to allow the host cells... Agent: National Taiwan Ocean University

20120276525 - Method and system for preventing virus-related obesity and obesity related diseases: A method for preventing obesity related to infection by an adipogenic adenovirus includes assaying a sample from a person to determine whether the person has been previously infected with an adipogenic adenovirus, and if the person has not been previously infected, providing the person with at least one sensor positioned... Agent:

20120276522 - Methods and compositions for determining virus susceptibility to integrase inhibitors: Methods and compositions for the efficient and accurate determination of HIV susceptibility to an integrase inhibitor and/or HIV replication capacity are provided. In certain aspects, the methods involve detecting in a biological sample a nucleic acid encoding an HIV integrase that comprises a primary mutation at codon 143, wherein the... Agent: Laboratory Corporation Of America Holdings

20120276521 - Oral fluid rapid assay for hepatitis c virus (hcv) antibodies using non-antibody labeling of lga molecules recognizing hcv peptide epitopes: A method and device to detect Hepatitis C (HCV) antibodies in oral fluid is provided. This method introduces a non-antibody detection molecule that labels all classes of patient antibodies in oral fluid, followed by the specific concentration of labeled anti-HCV antibodies by selective capture in a trapping zone consisting of... Agent:

20120276527 - Gene recombination screening methods: Methods and compositions for detecting recombination events are disclosed. Methods and compositions for expressing a gene of interest are also disclosed.... Agent:

20120276531 - Genes for prognosis of cancer: To provide a novel method for determining the risk of lymph node metastasis of breast cancer uses as an index the difference in the expression levels of marker genes in at least one material selected from the group consisting of a breast tissue and a breast cell of a patient.... Agent: Oriental Yeast Co., Ltd.

20120276528 - Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and... Agent: Celera Corporation

20120276536 - Hair shape susceptibility gene: A genetic polymorphism and a hair shape susceptibility gene that are related to hair shape, and a method for determining the genetic susceptibility to hair shape in individual test subjects are provided. Disclosed is a hair shape susceptibility gene, which overlaps with a haplotype block in in the 11q12.2 to... Agent: Kao Corporation

20120276537 - Homologous recombination in the oocyte: The present invention relates to a method of modifying a target sequence in the genome of a mammalian or avian oocyte by homologous recombination with a donor nucleic acid sequence, the method comprising the steps (a) introducing into the oocyte a zinc finger nuclease or a nucleic acid molecule encoding... Agent:

20120276530 - Label-free sensing of pna-dna complexes using nanopores: Embodiments disclosed herein relate to a method of detecting specific DNA sequences and the application of this method in the detection of pathogens, viruses, drug-resistant pathogens, genomic variations associated with disease/disorder susceptibility etc. based on specific signature sequences unique to the pathogens, viruses, drug-resistant pathogens or genomic variations. The method... Agent: Trustees Of Boston University

20120276540 - Method and probe set for detecting cancer: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer... Agent:

20120276533 - Method for simultaneously detecting polymorphisms of acetaldehyde dehydrogenase 2 and alcohol dehydrogenase 2: A probe for detection of at least 1 type of genetic polymorphism of the ALDH2 gene rs671 and the ADH2 gene rs1229984, a kit therefore, and methods of detecting the polymorphism(s).... Agent: Arkray, Inc.

20120276535 - Method for the diagnosis of limbal stem cell deficiency: The invention relates to a method for the diagnosis of limbal stem cell deficiency (LSCD) in a subject, based on detecting or quantifying the expression of the MUC5AC gene in a cornea sample from said subject.... Agent: Bioftalmik, S.l.

20120276529 - Mutated sumo isoforms and uses thereof: Disclosed herein are substantially pure nucleic acids encoding mutated SUMO isoforms, polypeptides, vectors, cells and methods of their use to identify and quantify protein SUMOylation in mammalian cells. Also disclosed is a dual affinity method for detecting a mutated SUMOylated protein substrate fragment.... Agent: Universite De Montreal

20120276534 - Probe for detecting polymorphism in exon 12 of npm1 gene and use thereof: The present invention relates to probes which detect a polymorphism(s) in exon 12 of the NPM1 gene, a kit therefor, and the method of detecting the polymorphism(s) thereof.... Agent: Arkray, Inc.

20120276532 - Sample processing device for pretreatment and thermal cycling: A sample processing device may include an opening, a sample pretreatment unit, a thermal cycling reaction unit, and a detection unit.... Agent: Chen & Chen, LLC

20120276538 - Sequence-specific methods for homogeneous, real-time detection of lamp products: Presented herein are methods and compositions for generating sequence-specific, secondary amplification products during Loop-mediated Isothermal Amplification (LAMP). Conventional LAMP produces a preponderance of high molecular weight DNA structures concatenated into self-complementary hairpins, which are not amenable to detection by routine probe-based hybridization methods, making multiplex detection of two or more... Agent: Becton, Dickinson And Company

20120276539 - Use of metastasis progressor s100a4 transcripts in body fluids of colorectal and gastric cancer patients: Transcript quantification of the metastasis progressor S100A4 is performed in body fluids. Methods, assays and kits relying on this quantification are disclosed that have diagnostic and/or prognostic applications in colorectal and gastric cancer patients.... Agent: Max-delbrueck-centrum F&#xdc R Molekulare Medizin

20120276543 - Microfabricated crossflow devices and methods: A microfluidic device is provided for analyzing or sorting biological materials, such as polynucleotides, polypeptides, proteins, enzymes, viruses and cells. The invention can be used for high throughput or combinatorial screening. The device comprises a main channel and an inlet channel that communicate at a droplet extrusion region so that... Agent: California Institute Of Technology

20120276544 - Microfabricated crossflow devices and methods: A microfluidic device is provided for analyzing or sorting biological materials, such as polynucleotides, polypeptides, proteins, enzymes, viruses and cells. The invention can be used for high throughput or combinatorial screening. The device comprises a main channel and an inlet channel that communicate at a droplet extrusion region so that... Agent: California Institute Of Technology

20120276541 - Microplates, reaction modules and detection systems: Microplates, reaction modules and optical detection systems for chemical and/or bio-chemical reactions including polymerase chain reactions.... Agent:

20120276542 - Quantification of a minority nucleic acid species: The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.... Agent: Sequenom, Inc.

20120276545 - Method for using division arrested cells in screening assays: Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.... Agent: Life Technologies Corporation

20120276546 - Periodontal disease marker: A marker for determining the onset of periodontal disease and a marker far determining the progression stage of periodontal disease, each containing autoinducer-2.... Agent: Kao Corportation

20120276547 - Aptamers selected against live s. pyogenes cells: The invention is directed to aptamers, methods and kits comprising same for detecting Streptococcus pyogenes. The method of screening a subject for Streptococcus pyogenes involves obtaining a body sample from the subject; contacting the sample or a bacterial culture of the sample with an aptamer or a panel of aptamers... Agent: Governors Or The University Of Alberta

20120276548 - Multimer glycosylated nucleic acid binding protein conjugates and uses thereof: The technology relates in part to multimer conjugates comprising a scaffold linked to two or more polypeptides that specifically interact with a nucleic acid containing beta-D-glucosyl-hydroxymethylcytosine or beta-D-glucosyl-hydroxymethyluracil. The scaffold can be chosen from an antibody, an antibody fragment, a multimerized binding partner that interacts with a binding partner counterpart... Agent: Sequenom, Inc.

20120276550 - Microfluidics apparatus and methods: This invention relates to microfluidics apparatus and methods for particle concentration in sensors for sensing biological entities such as cells, spores and the like. We describe a microfluidic sensor for sensing biological particles including a particle concentration device for performing concentration of particles in three dimensions. The sensor device comprises... Agent:

20120276549 - Photonic biosensors incorporated into tubing, methods of manufacture and instruments for analyziing the biosensors: Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection... Agent: The Board Of Trustees Of The University Of Illinois Sru Biosystems, Inc.

20120276554 - Isolation and use of ryanodine receptors: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families. The genes and their corresponding polypeptides have a number of uses including but not limited to the development of screens to identify insecticidally active compounds. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in... Agent: E.i. Du Pont De Nemours And Company

20120276553 - Mesenchymal precursor cell: A method of enriching mesenchymal precursor cells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differentiated mesenchymal cells, or iii) expression levels of... Agent: Angioblast Systems, Incorporated

20120276555 - Method of using non-rare cells to detect rare cells: The invention provides seminal computational approaches utilizing data from non-rare cells to detect rare cells, such as circulating tumor cells (CTCs). The invention is applicable at two distinct stages of CTC detection; the first being to make decisions about data collection parameters and the second being to make decisions during... Agent:

20120276558 - Kits for multiparametric phospho analysis: As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise... Agent: Nodality, Inc.

20120276556 - Ligating bdca-2 protein for the purpose of isolating or modulating dendritic cells: The invention provides antigen-binding fragments specific for dendritic cells and effective in treatment and/or diagnosing a variety of disorders. Methods of use are also provided as are methods for screening for additional such antigen-binding fragments and the products obtained thereby.... Agent: Miltenyi Biotech Gmbh

20120276557 - Method for the quantitative and qualitative characterization of antigen-specific t cells recognizing a specific antigen: e

20120276551 - Methods predicting risk of an adverse clinical outcome: Provided are methods for evaluating the risk of an adverse clinical outcome in a subject, deciding whether to discharge or continue treating a subject (e.g., on an inpatient basis), or to initiate or terminate treatment, selecting a subject for participation 5 in a clinical study, and selecting a therapeutic treatment... Agent: Critical Care Diagnostics, Inc.

20120276552 - Serum spla2-iia as diagnosis marker for prostate and lung cancer: Methods for diagnosing prostate cancer and lung cancer are disclosed. The methods include obtaining a biological sample from a subject, determining a level of serum secretory phospholipase A2-IIA in the biological sample, comparing the level of serum secretory phospholipase A2-IIA with a baseline level of serum secretory phospholipase A2-IIA, and... Agent: University Of Cincinnati

20120276560 - Biomarkers for assessing sialic acid deficiencies: The present invention relates to methods of diagnosing, monitoring and assessing conditions of sialic acid deficiency such as Hereditary Inclusion Body Myopathy (HIBM) and to methods of predicting/determining responsiveness to treatment.... Agent:

20120276561 - Marker protein for type-2 diabetes: The present invention provides a marker protein for the early detection of type II diabetes, antibodies directed to the marker protein and their use in a diagnostic method for type II diabetes and in drug development.... Agent: Hoffmann-la Roche Inc.

20120276559 - Thrombospondin fragments and uses thereof in clinical assays for cancer and generation of antibodies and other binding agents: The invention relates to thrombospondin fragments found in plasma, their use or use of portions thereof in diagnostic methods, as method calibrators, method indicators, and as immunogens, and as analytes for methods with substantial clinical utility; and their detection in plasma or other bodily fluids for purpose of diagnostic methods,... Agent: W2 Holdings, Inc.

20120276562 - 5.9 kda peptide immunoassay method: Disclosed is an immunoassay method whereby a 5.9 kDa peptide which results from the degradation of the α-E chain and α chain of human fibrinogens and which is used as a peptide marker for diagnosing hepatic disease can be specifically assayed in a biological sample containing contaminating peptides by bringing... Agent: Nitto Boseki Co., Ltd.

20120276564 - Luciferins: Novel luciferins, methods of making luciferins, and uses of the same are disclosed.... Agent: University Of Massachusetts

20120276563 - Method for screening a potential modulator compound of a taste receptor: A method for screening a potential modulator compound of a taste receptor wherein use is made of a BRET technique.... Agent:

20120276566 - Medium for the specific detection of resistant microorganisms: A method for distinguishing among a first group of microorganisms, belonging to a first taxon of yeasts that is resistant to an antifungal; a second group of microorganisms, belonging to a second taxon of yeasts that is different than the first taxon of yeasts, and that exhibits the mechanism of... Agent: Biomerieux

20120276565 - Stabilization of enzymes with stable coenzymes: Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems... Agent:

20120276567 - Talaromyces transformants: The invention relates to a Talaromyces transformant comprising one or more recombinant gene, capable of producing cellulase in the absence of cellulase inducer in a glucose medium, having a cellulase activity of 2 WSU/ml or more, in 16 times or more diluted supernatant or broth.... Agent: DsmIPAssets B.v.

20120276568 - Dry test strip and method for measuring creatinine: A dry test strip for measuring creatinine comprises: a support; a reagent layer that is disposed on the support; a reagent holding layer that is disposed on the reagent layer; and a connection layer that is composed of an adhesive which adhesively bonds the reagent layer to the reagent holding... Agent: Arkray, Inc.

20120276569 - Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity: This invention relates to methods for determining the activity of Lp-PLA2 in at least one sample from an animal. The invention also relates to methods for determining the inhibition of Lp-PLA2 activity in samples from animals that are administered an Lp-PLA2 inhibitor.... Agent:

20120276570 - Peptide antibody depletion and its application to mass spectrometry sample preparation: The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant and/or well-ionizing and/or proteotypic peptides from the sample. Also described are methods for identifying well-ionizing peptides for use in this and other... Agent: The Johns Hopkins University

20120276571 - Method of analyzing formation and phase transition characteristic of amorphous calcium carbonate: Provided is a method of analyzing a formation and a phase transition characteristic of amorphous calcium carbonate that may adjust a preferred orientation in crystalline calcium carbonate as well as an amorphous state of calcium carbonate using a water-soluble material containing an amino acid in an operation of forming calcium... Agent:

20120276572 - Methods and compositions for identifying and validating modulators of cell fate: The invention provides for compositions and methods for identifying and validating modulators of cell fate, such as such as maintenance, cell specification, cell determination, induction of stem cell fate, cell differentiation, cell dedifferentiation, and cell trans-differentiation. The invention relates to reporter nucleic acid constructs, host cells comprising such constructs, and... Agent: Chromocell Corporation

20120276574 - Microfluidic mixer: e

20120276573 - Nanotube structures, methods of making nanotube structures, and methods of accessing intracellular space: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making a structure including nanotubes, a structure including nanotubes, methods of delivering a fluid to a cell, methods of removing a fluid to... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20120276576 - Porous polymer monoliths, processes for preparation and use thereof: The present invention generally relates to porous polymer monoliths. The present invention also relates to processes for the preparation of porous polymer monoliths, storage mediums formed from porous polymer monoliths and use thereof in the drying and storage of body fluids including blood and blood plasma samples.... Agent:

20120276575 - Unit and device for the preparation of cells and/or particles in a liquid and method for microscopic analysis: A unit (10) for the preparation of cells contained in a liquid comprises a storage chamber (20) configured to store the liquid containing the cells and to release the stored liquid via an exit opening (22) upon the application of a predetermined external force, in particular a centrifugal force. A... Agent:

20120276577 - Method for determining the susceptibility of a cell strain to drugs: u

20120276581 - Method for preserving cancellous bone samples and preserved cancellous bone tissue: The claimed subject matter is based on the finding that it is possible to cryopreserve cancellous bone tissue with viable cells (after reconstitution by either thawing or rehydration), the viability after reconstitution being comparable to that of a fresh sample (without freezing) and of beneficial value for use in, for... Agent: Core Dynamics Ltd.

20120276580 - Microorganism concentration process and concentration agent for use therein: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing an adsorption buffer-modified inorganic concentration agent that is prepared by a process comprising (1) contacting at least one inorganic concentration agent with at least one cation-containing salt solution, so as to wet at least a portion... Agent:

20120276579 - Organic compounds: The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the... Agent: Novartis Ag

20120276578 - Phasor method to fluorescence lifetime microscopy to discriminate metabolic state of cells in living tissue: “A label-free imaging method to monitor stem cell metabolism discriminates different states of stem cell as they differentiate in a living tissues. We use intrinsic fluorescence biomarkers and the phasor approach to Fluorescence Lifetime Imaging Microscopy (FLIM). We identify and map intrinsic fluorophores such as collagen, retinol, retinoic acid, flavins,... Agent:

20120276582 - Disposable cassette and method of use for blood analysis on blood analyzer: A disposable cassette for blood analysis includes a housing having an upper panel and a sampling section having a filling inlet; at least one pair of chambers in a form of depression of the upper panel of the housing and sealed by a diaphragm; portions of the diaphragm over the... Agent:

20120276583 - Method, processor and carrier for processing frozen slices of tissue of biospecimens: A method for processing frozen slices of tissue of biospecimens mounted on or adhered to glass slides, i.e. forming a frozen section (2), and arranged on a carrier (1), has the following steps: a.) immersing the frozen tissue slices in a fixative, b.) staining the tissue slice, c.) dehydrating the... Agent: Milestone S.r.l.

20120276584 - Stabilized hematoxylin: A stabilized hematoxylin composition is disclosed that includes one or both of a host compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process without undue degradation prior to use of the composition to stain a biological sample. Methods of using and... Agent:

20120276585 - Method for producing fermentation products from lignocellulose-containing material: The present invention relates to a method for producing a hydrolysate of from lignocellulose-containing material, comprising pre-treatment with low temperature, hydrolysis and fermentation, wherein hydrolysis is performed by contacting the lignocellulose-containing material with an enzyme composition comprising at least 10% xylanase enzyme protein w/w%.... Agent: Novozymes A/s

20120276586 - Desmosterol-producing yeast strains and uses thereof: The invention concerns the production of cholesterol of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention also concerns the use of the inventive Fungus for producing non-marked and marked cholesterol.... Agent: Aventis Pharma S.a.

20120276587 - Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids: The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms by engineering a microorganism for increased carbon flux towards mevalonate production in the following enzymatic pathways: (a) citrate synthase, (b) phosphotransacetylase, (c) acetate kinase, (d) lactate dehydrogenase, (e) malic enzyme,... Agent: Danisco US Inc.

20120276589 - Method for producing proteins comprising non-natural amino acids incorporated therein: Producing proteins incorporating non-natural amino acids can involve introducing genes into and knocking inherent genes out of eukaryote-type cells. Genes to be introduced include genes encoding eukaryote-type aminoacyl tRNA synthetase mutants having enhanced specificity to non-natural amino acids, compared with specificity to similar natural amino acids, and tRNA genes for... Agent: Riken

20120276590 - Recombinant silkworm and silkworm protein comprising heterologous protein produced by the recombinant silkworm: The present invention relates to a recombinant organism having any one of nucleic acids (i) to (iv) introduced therein: (i) a nucleic acid having a base sequence of SEQ ID NO: 1; (ii) a nucleic acid encoding a protein having an amino acid sequence of SEQ ID NO: 2; (iii)... Agent: Okamoto Corporation

20120276588 - Use of galerina marginata genes and proteins for peptide production: The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic... Agent: Board Of Trustees Of Michigan State University

20120276591 - Compositions and methods for use for antibodies against sclerostin: The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat a pathological disorder that is mediated by sclerostin or disease related to bone abnormalities such as osteoporosis.... Agent:

20120276592 - Microfluidic system and method for a polymerase chain reaction: A microfluidic system for a polymerase chain reaction is disclosed. The system includes a substrate having three chambers fluidically connected to one another in series, which chambers are held at different temperature levels. An elastic film on the substrate closes the chambers, wherein the chambers connected to one another in... Agent: Robert Bosch Gmbh

20120276593 - Use of cellulase and glucoamylase to improve ethanol yields from fermentation: An improved saccharification process comprises the use of a glucoamylase and at least one cellulase. The improved saccharification process results in improved yields of fermentations products, such as ethanol. In one embodiment, the improved saccharification process results in an increased yield of up to 0.5% to 1% ethanol using commercially... Agent: Danisco US Inc.

20120276594 - Cellobiohydrolase variants: The present invention relates to cellobiohydrolase variants having improved thermostability and/or thermoactivity in comparison to wild-type Myceliophthora thermophila CBH2b.... Agent: Codexis, Inc.

20120276595 - Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.... Agent: Danisco US Inc.

20120276596 - Modified biomaterial, uses thereof and modification methods: The present invention relates to the fields of biomass technology, and more precisely to applications of packaging, and coating products for food and cosmetics. The present invention relates to a method of modifying a polymeric polysaccharide matrix and to a method of coating a product to impart new properties to... Agent: Teknologian Tutkimuskeskus Vtt

20120276597 - Process for production of fructo-oligosaccharides: A microbial consortium comprises of an Aureobasidium sp. to metabolise a sugar substrate into fructooligosaccaride, glucose and fructose and a Pachysolen sp to metabolise the glucose and the fructose into ethanol.... Agent: Tata Chemicals Limited

20120276598 - Method for producing an l-amino acid: A method for efficiently producing an L-amino acid, especially L-lysine, by using a γ-proteobacterium is provided. In a method for producing an L-amino acid comprising culturing a bacterium belonging to γ-Proteobacteria and having an ability to produce an L-amino acid, for example, an Enterobacteriaceae bacterium such as Escherichia coli, in... Agent:

20120276599 - Ketoreductase polypeptides for the production of (r)-3-hydroxythiolane: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.... Agent: Codexis, Inc.

20120276600 - Process for preparing dipeptidyl peptidase iv inhibitors and intermediates therefor: e

20120276601 - Method for producing acrylamide using microbial catalyst: A method for producing acrylamide from acrylonitrile by a biocatalyst method, wherein both evaporation of acrylonitrile into a gas phase and damaging of a catalyst by stirring are prevented, is provided. In the present invention, the production of acrylamide from acrylonitrile by the biocatalyst method comprises feeding acrylonitrile into an... Agent: Dia-nitrix Co., Ltd.

20120276602 - Method for treatment of oil: The present invention relates to a method for treatment of oil with a lipolytic enzyme which comprises contacting of the oil with particles of base-containing porous amorphous silica.... Agent: Novozymes A/s

20120276604 - Microorganisms for the production of methacrylic acid: The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric... Agent: Genomatica, Inc.

20120276605 - Microorganisms for the production of methacrylic acid: The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric... Agent: Genomatica, Inc.

20120276603 - Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities: The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms via the heterologous expression of the mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus.... Agent: Danisco US Inc.

20120276606 - Recombinant microorganisms with 1,3-butanediol-producing function and uses thereof: e

20120276607 - Zymomonas with improved xylose utilization in stress conditions: Strains of xylose utilizing Zymomonas with improved xylose utilization and ethanol production during fermentation in stress conditions were obtained using an adaptation method. The adaptation involved continuously growing xylose utilizing Zymomonas in media containing high sugars, acetic acid, ammonia, and ethanol.... Agent: E. I. Du Pont De Nemours And Company & Alliance For Sustainable Energy LLC

20120276608 - Multivalent immunoglobulin-based bioactive assemblies: The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and which may be monospecific or bispecific. The disclosed methods and compositions provide a... Agent: Ibc Pharmaceuticals, Inc.

20120276609 - Stabilization of perhydrolases: Disclosed herein are enzyme powders comprising a spray-dried formulation of at least one CE-7 esterase, at least one oligosaccharide excipient, and optionally at least one surfactant. Also disclosed herein is a process for producing peroxycarboxylic acids from carboxylic acid esters using the aforementioned enzyme powders. Further, disinfectant and laundry care... Agent:

20120276610 - Isolation of a protein responsible for uranium (vi) reduction: The present invention relates to the isolation and characterization of a protein responsible for the reduction of uranium (VI) to uranium (IV). The present invention extends to the use of the isolated protein in the reduction of uranium (VI) to uranium (IV) and further extends to a process for the... Agent: University Of The Free State

20120276611 - Recombinantly modified plasmin: Polynucleotides and polypeptides relating to a recombinantly modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the... Agent:

20120276613 - Modified vaccinia ankara virus variant and cultivation method: The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a... Agent: Bavarian Nordic A/s

20120276612 - Phage of acinetobacter baumannii: The present invention provides an isolated Acinetobacter baumannii phage, comprising one or more genomic sequences selected from the group consisting of sequences of SEQ. ID. NO: 1, 2, 3 and 4, and sequences having more than 80% homology thereof. The phages of the present invention infect Acinetobacter baumannii specifically, and... Agent: Tzu Chi Buddhist General Hospital

20120276614 - Process for producing poxviruses and poxvirus compositions: The present invention relates to compositions and pharmaceutical compositions comprising poxviruses and more particularly extracellular enveloped viruses. The present invention also relates to a process for producing poxviruses and poxviruses obtained thereof. Moreover, the present invention also relates to the use of said poxvirus and said composition for the preparation... Agent: Transgene S.a.

20120276615 - Recombinant bacterium capable of removing mercury (ii) species, cadmium (ii) and copper (ii) in presence of other heavy metals from polluted sites, product for the bioremediation, process of obtaining the product and method of bioremediation: A heavy metal-resistant recombinant bacterium capable to remove mercury (II) species, cadmium and copper (II) in presence of other heavy metals from polluted sites, which corresponds to Cupriavidus metallidurans strain MSR33, deposited under the access number NRRL B-50299, a product for the bioremediation of environments contaminated with heavy metals, where... Agent:

20120276616 - Method and system for methane separation and purification from a biogas: The method and system for methane separation and purification from a biogas includes collecting a raw Biogas gas stream having methane, carbon dioxide, water, sulfur compounds and non-methane organic compound (NMOC) constituents. The Biogas stream is fed into the intake of a liquid sulfur scrubber or a sulfur adsorber unit... Agent:

20120276617 - Coatings containing polymer modified enzyme for stable self-cleaning of organic stains: Temporary active coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the... Agent: Toyota Motor Engineering & Manufacturing North America, Inc.

20120276618 - Hydrolases, nucleic acids encoding them and methods for biocatalytic synthesis of structured lipids: Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils,... Agent:

20120276619 - Method for recycling paper products glued and/or coated with biodegradable polymers: o

20120276620 - Portable organ transportation system: Disclosed is portable organ transportation system including a mobile cart and an organ container. At least one of the mobile cart and the organ container include a latch for releasably attaching the organ container to the mobile cart. The organ container may be a portable organ preservation device or a... Agent: Lifeline Scientific, Inc.

20120276621 - Multi-way sorter system and method: Provided herein are improved multi-way cell sorter systems and methods. For example, provided are systems and methods for the collection of cells that are sorted in multiple directions. The systems and methods allow for the construction of a multi-way sorter (e.g., a ten-way sorter in the space that currently only... Agent:

20120276622 - Apparatus and method for high-throughput micro-cell culture with mechanical stimulation: A method and apparatus for high-throughput micro-cell culture with mechanical stimulation is disclosed. In one embodiment, the apparatus includes a cell culture vessel and a fluid pressure supply unit. The cell culture vessel has a membrane, a culture medium chamber, and a pressure chamber; and the fluid pressure supply unit... Agent: Chang Gung University

20120276623 - Dna removal in target molecule purification: Removal of genomic DNA from biological samples using cation exchange is described.... Agent: Bio-rad Laboratories, Inc.

20120276624 - Methods for identifying factors for differentiating definitive endoderm: Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.... Agent:

20120276625 - Method for producing mesenchymal stem cells from human pluripotent stem cells, and mesenchymal stem cells produced by same: Provided is a method for producing mesenchymal stem cells from human pluripotent stem cells, the method including: a) forming embryonic bodies from human pluripotent stem cells; b) attaching the embryonic bodies to a culture dish to induce natural differentiation of the embryonic bodies into mesenchymal stem cells; and c) performing... Agent: Snu R&db Foundation

20120276626 - Synthetic surfaces for culturing stem cell derived cardiomyocytes: Synthetic surfaces suitable for culturing stem cell derived cardiomyocytes contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived cardiomyocytes in chemically defined media.... Agent:

20120276627 - Synthetic mimics of mir-124: Embodiments concern methods and compositions involving miR-124 mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-124 sequence and a complementary passenger strand.... Agent:

20120276628 - Automated systems and methods for isolating regenerative cells from adipose tissue: A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer;... Agent: General Electric Company

20120276629 - Methods for isolating stem cells: Disclosed is a method for isolating stem cells. The method uses a specially designed apparatus including: a container containing an aspirate; a piston having an outer diameter corresponding to the inner diameter of the container and having at least one through-hole; and a connection tube adapted to feed an enzyme... Agent: Hee Young Lee

20120276630 - Dry powder cells and cell culture reagents and methods of production thereof: The present invention relates generally to nutritive medium, medium supplement, media subgroup and buffer formulations. Specifically, powdered nutritive medium, supplement, subgroup formulations, cell culture media comprising all of the necessary nutritive factors for in vitro cell cultivation, buffer formulations that produce particular ionic and pH conditions upon reconstitution with a... Agent: Life Technologies Corporation

20120276631 - Methods for controlling the galactosylation profile of recombinantly-expressed proteins: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.... Agent: Abbott Laboratories

20120276632 - Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics: The present invention provides a cell culture medium supplement comprising plasma-free platelet lysate and medium supplemented with this supplement. The present invention further provides a method for preparing the supplement comprising the steps of (a) preparing platelet rich plasma; (b) removing the plasma; and (c) lysing the platelets.... Agent: Medical University Of Graz

20120276633 - Supplying treated exhaust gases for effecting growth of phototrophic biomass: There is provided a process for growing a phototrophic biomass in a reaction zone. The process includes treating an operative carbon dioxide supply-comprising gaseous material feed so as to effect production of a carbon dioxide-rich product material. The carbon dioxide concentration of the carbon dioxide-rich product material is greater than... Agent: Pond Biofuels Inc.

20120276634 - somatic embryogenesis and embryo harvesting and method and apparatus for preparing plant embryos for plant production: Described herein are methods and media for facilitating somatic embryogenesis and for collecting, conditioning, and transferring the washed embryos onto a substrate and into an environment suitable for conditioning the embryos for a desired period of time so they become germination-competent for plant production. The described plant embryo cleaning apparatus... Agent: Arborgen Inc.

20120276635 - Fluidic device: A fluidic device for cell electroporation, cell lysis, and cell electrofusion based on constant DC voltage and geometric variation is provided. The fluidic device can be used with prokaryotic or eukaryotic cells. In addition, the device can be used for electroporative delivery of compounds, drugs, and genes into prokaryotic and... Agent: Purdue Research Foundation

20120276636 - Method for improving induced pluripotent stem cell generation efficiency: The present invention provides a method for improving iPS cell generation efficiency, which comprises a step of introducing a Myc variant having the following features: (1) having an activity to improve iPS cell generation efficiency which is comparative to, or greater than that of c-Myc; and (2) having a transformation... Agent: Kyoto University

20120276637 - Genetically engineered cyanobacteria: The disclosed embodiments provide cyanobacteria spp. that have been genetically engineered to have increased production of carbon-based products of interest. These genetically engineered hosts efficiently convert carbon dioxide and light into carbon-based products of interest such as long chained hydrocarbons. Several constructs containing polynucleotides encoding enzymes active in the metabolic... Agent: South Dakota State University

20120276639 - Genetically engineered recombinant escherichia coli producing l-tryptophan having originally l-phenylalanine productivity, and method for producing l-tryptophan using the microorganism: The present invention relates to a microorganism having L-tryptophan productivity and a method for producing L-tryptophan using the same. More precisely, the present invention relates to the recombinant E. coli strain CJ600 (KCCM 10812P) having tryptophan productivity produced from the mutant form (KFCC 10066) of E. coli having L-phenylalanine productivity,... Agent: Cj Cheiljedang Corporation

20120276638 - Methods of improving the introduction of dna into bacterial cells: The present invention relates to methods of improving the introduction of DNA into bacterial host cells.... Agent: Novozymes, Inc.

20120276640 - Polypeptides having cellobiohydrolase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

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