|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology October categorized by USPTO classification 10/12Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 10/25/2012 > 122 patent applications in 71 patent subcategories.
20120270203 - Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect: The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage,... Agent:
20120270202 - Pre-transplant accommodated organs resistant to anti-donor immunity: This invention includes the composition of organ grafts accommodated prior to transplantation and therefore resistant to rejection by preformed antibodies. Accommodation is achieved within the donor animal by administration of sub-lethal levels of accommodation inducing factors derived from animals sensitized to the donor.... Agent: The Board Of Regents Of The University Of Nebraska
20120270204 - Magnetic sorting of mammalian sperm having damaged membranes: A method for magnetic sorting of mammalian sperm cells having damaged membranes is described. In an embodiment of the invention, carboxyl-group functionalized magnetic particles are conjugated to propidium iodide, the resulting composition is mixed with a sample of sperm cells, and sperm cells bound to magnetic particles are separated by... Agent:
20120270207 - Analyte detection: The present disclosure provides methods and/or kits for detecting an analyte in a sample. Some embodiments provide a method for detecting a non-nucleic acid analyte in a sample using a solid substrate comprising a bound immobilisation agent and an antibody capture agent and a detectable agent, which can bind to... Agent:
20120270205 - High-flux chemical sensors: The present invention relates to the field of chemical detection. Specifically, the invention provides devices that respond quickly to various target chemical analytes present in the environment. Responses are based on a change in an electrical property (such as impedance or resistance) caused by adsorption or absorption of the target... Agent:
20120270208 - Synthetic antigens for the detection of antibodies to hepatitis c virus: Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for the detection of... Agent: Innogenetics, S.a.
20120270206 - Systems and methods for analyzing nucleic acid sequences: The invention relates to systems and methods for analyzing clinically relevant nucleic acid sequences.... Agent: University Of Massachusetts
20120270211 - Chemically-enhanced primer compositions, methods and kits: A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a... Agent: Life Technologies Corporation
20120270210 - Method and reagent for gene sequence analysis: Provided is a nucleic acid substrate which has nucleic acid substrate characteristics equivalent to those of dATP, has a low substrate specificity for luciferase, exerts no negative effect on enzymatic reactions such as a complementary-strand synthesis, and therefore is particularly suitable for the pyrosequencing method. As a nucleic acid substrate... Agent:
20120270209 - Systems, devices, and methods for specific capture and release of biological sample components: Living cells can be selectively and reversibly bound to functionalized dissolvable material (e.g., cross-linked hydrogel compositions) and subsequently released from the composition as viable cells. In some examples, the cells are released by reducing the degree of cross-linking within a functionalized hydrogel composition and/or dissolving the functionalized hydrogel composition bound... Agent: The General Hospital Corporation
20120270216 - Compositions and methods for detecting and identifying salmonella enterica strains: The present specification describes several novel SNPs of Salmonella enterica subsp. enterica. SNP profiles comprising allelic compositions at each SNP position are described which may be used to identify and differentiate different strains and serovars of Salmonella enterica subsp. enterica. The specification also describes several compositions, methods and kits useful... Agent: Life Technologies Corporation
20120270220 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the... Agent: Cornell Research Foundation, Inc.
20120270218 - Method for analyzing cervical lymph node metastasis, and tumor marker for head and neck cancer: Provided are a method for analyzing metastasis of head and neck cancer to a cervical lymph node, and a tumor marker for head and neck cancer used therein. Specifically, provided is a method for analyzing metastasis of head and neck cancer to a cervical lymph node, involving: measuring an expression... Agent:
20120270214 - Methods for localized in situ detection of mrna: The present invention relates to the detection of RNA in a sample of cells. More particularly, the present invention relates to the localized detection of RNA in situ. The method relies on the conversion of RNA to complementary DNA prior to the targeting of the cDNA with a padlock probe(s).... Agent:
20120270212 - Methods for non-invasive prenatal ploidy calling: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father.... Agent: Gene Security Network Inc.
20120270219 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses: The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule... Agent: Millennium Pharmaceuticals, Inc.
20120270215 - Probe for detecting polymorphism in cyp3a gene, method of detecting polymorphism, method of evaluating drug efficacy, and reagent kit for detecting polymorphism: Provided in the present disclosure is a probe for detecting polymorphism that enables a simple detection of polymorphism in the CYP3A gene with high sensitivity.... Agent:
20120270217 - Restriction endonuclease enhanced polymorphic sequence detection: Provided in part herein is an improved method for the detection of specific polymorphic alleles in a mixed DNA population. The method comprises enriching the relative percentage of a given polymorphic allele that is exponentially amplifiable by PCR. Provided also are methods for selectively enriching target nucleic acid, for example,... Agent: Sequenom, Inc.
20120270213 - Screening method for cell aging: The present invention relates to a method for increasing the chronological lifespan of a cell comprising disrupting the function of at least one of the SAGA1 SLIK and/or SALSA complexes in said cell.... Agent: Chronos Therapeutics Limited
20120270226 - matching of forensic results: A method of analysing and comparing a test sample with another sample is provided, wherein: the test sample is analysed, the analysis producing test sample analysis data set; the test sample analysis data set is processed to give a test sample results data set; defining a search term relating to... Agent: Forensic Science Service Limited
20120270225 - Device and apparatus: A device (1) for carrying out a chemical or biochemical reaction and detecting the results, such as an assay to detect a target nucleic acid in a sample, said device comprising (i) a first well (8) in which a chemical or biochemical reaction such as a nucleic acid amplification reaction... Agent: The Secretary Of State For Environment, Food & Rural Affairs Acting Through The Animal Health And
20120270227 - Glycine n-methyltransferase (gnmt) animal model and use thereof: The present invention is a method of detecting abnormality of liver in a subject, comprising: (i) measuring expression level of genes consisting of survival and proliferation genes, oncogenes, tumor suppressor genes, one carbon metabolism genes and glycogen storage disease related genes, and (ii) determining expression level of genes are indicative... Agent: National Yang-ming University
20120270224 - Method for accurate assessment of dna quality after bisulfite treatment: The present invention is directed to methods useful for determining DNA quality after bisulfite treatment. The methods include a PCR-based assay, which allows ab-initio assessment of the DNA quality after bisulfite treatment and can help to prevent inaccurate quantitative measurement resulting from poor bisulfite treatment.... Agent: Sequenom, Inc.
20120270222 - Method for the efficiency-corrected real-time quantification of nucleic acids: The present invention concerns a method for the quantification of a target nucleic acid in a sample comprising the following steps: (i) determination of the amplification efficiency of the target nucleic acid under defined amplification conditions, (ii) amplification of the target nucleic acid contained in the sample under the same... Agent: Roche Diagnostics Operations, Inc.
20120270221 - Methods of sequencing fluorophore-quencher fret-aptamers: The present invention describes methods for the production and selecting of single chain (single-stranded) fluorescence resonance energy transfer (“FRET”) DNA or RNA aptamers containing fluorophores (F) and quenchers (Q) at various loci within their structures, such that when its specific matching analyte is bound and the FRET-aptamers are excited by... Agent: Pronucleotein Biotechnologies, LLC
20120270223 - Oligonucleotide sequences that identify species of animal: The present invention provides a method for identifying animal species, said method comprises a step of amplifying a DNA fragment by PCR using a DNA in a sample as a template and animal-specific DNA sequences as a primer pair, wherein the animal-specific DNA sequences are derived from a ATP synthase... Agent: National Institute Of Agrobiological Sciences
20120270228 - Predictors of patient response to treatment with egf receptor inhibitors: The present invention provides methods and compositions to facilitate determining whether an EGFR-expressing cancer in an individual is an EGFR inhibitor-responsive cancer, as well as methods for determining the likelihood that a patient having an EGFR-expressing cancer will exhibit a beneficial response to an EGFR inhibitor therapy. The methods generally... Agent: Genomic Health, Inc.
20120270229 - Device for detection of analytes and uses thereof: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.... Agent: Invisible Sentinel, Inc.
20120270232 - Characterization of granulocytic ehrlichia and methods of use: The present invention relates, in general, to methods of screening a sample obtained from a subject for antibodies relating to granulocytic ehrlichia (GE) infection.... Agent: Antigenics Inc.
20120270231 - Lattice-mismatched core-shell quantum dots: The disclosure relates to lattice-mismatched core-shell quantum dots (QDs). In certain embodiments, the lattice-mismatched core-shell QDs are used in methods for photovoltaic or photoconduction applications. They are also useful for multicolor molecular, cellular, and in vivo imaging.... Agent:
20120270230 - Mutant g-protein coupled receptors and methods for selecting them: The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the... Agent: Heptares Therapeutics Limited
20120270236 - Voltage-gated proton channel, hv1, and uses therefor: Nucleic acid and protein sequences relating to a proton channel (HvI) are disclosed. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the HvI gene and protein are disclosed. Also provided are methods of identifying modulators of HvI activity, methods of geno typing subjects with respect to... Agent: Children's Medical Center Corporation
20120270239 - Melanoma prognostic model using tissue microarrays and genetic algorithms: The invention provides a method for determining the risk that a patient diagnosed with melanoma will develop a recurrence of melanoma comprising: a) determining the level of expression for each marker of a panel of markers, wherein the panel comprises activating transcription factor 2, p21WAF1, p16INK4A, β-catenin, and fibronectin and... Agent:
20120270237 - Methods for the identification of kinase interacting molecules and for the purification of kinase proteins: The present invention relates to immobilization compounds (I), immobilization products and preparations thereof as well as methods and uses for the identification of kinase interacting compounds or for the purification or identification of kinase proteins.... Agent: Cellzone Ag
20120270238 - Peptides that bind the alpha-fetoprotein (afp) receptor and uses thereof: The present invention provides an active binding sequence of mammalian alpha-fetoprotein (AFP) to the receptor of AFP (AFPr or RECAP). The sequence is embodied in peptides comprising Lys-Glx-Glx-Xaa-Leu-Ile-Asn (SEQ. ID. NO: 1) and variants thereof, wherein GIx means GIn or GIu, each GIx being selected independently of the other, and... Agent:
20120270233 - Association of biomarkers with patient outcome: The present method relates to quantification of prognostic and predictive biomarkers of the PDK/AKT/mTOR pathway, such as GSK3β, S6, CREB, PTEN, AKT and mTOR, using AQUA® analysis to estimate both patient risk and benefit of treatment to patients diagnosed with glioblastoma. Unlike traditional IHC, the AQUA® system is objective and... Agent: Historx, Inc.
20120270234 - Ddr2 protein with activated kinase activity and preparation method thereof: The present invention relates to a protein containing a modified DDR (Discoidin Domain Receptor) 2 cytosolic tyrosine kinase domain having an increased autophosphorylation and tyrosine kinase activity; a method for preparing a large amount of a protein containing DDR2 cytosolic tyrosine kinase domain, having an increased autophosphorylation and tyrosine kinase... Agent: Korea Institute Of Science And Technology
20120270240 - Detection reagents for tyrosine kinase activity and methods of use thereof: Dual colored fluorescent indicators of specific tyrosine kinase activity and methods of use thereof are disclosed.... Agent:
20120270242 - Immunochemical detection of single target entities: The present invention relates to immunochemical visualization and quantification of single target entities, such as single molecules, single molecular structures, single particles, etc. in samples wherein said single entities are immobilized. In particular, the invention relates to methods for visualization and quantification of single units of biological or chemical targets,... Agent:
20120270241 - Systems and methods for evolving enzymes with desired activities: The present invention provides a new method for engineering or evolving enzymes to have desirable characteristics. Among the desirable characteristics is the ability to control catalytic activity through the use of a trigger molecule that rescues a catalytic site defect introduced during the engineering process. The method includes co-evolving enzyme... Agent:
20120270235 - Membrane biosensor having multi-hole film attached thereto and method for measuring immunological reaction or enzymatic reaction using the same: The present invention relates to a membrane sensor having a multi-hole film attached thereto and a method for measuring immunological reactions or enzymatic reactions using the same. More specifically, the present invention relates to a membrane sensor in which a multi-hole film is joined to the top of a membrane... Agent: Infopia Co., Ltd.
20120270243 - Diagnosing and managing venous thromboembolism and intracardiac thrombi using a provoked d-dimer test: The present invention provides methods for diagnosing a venous thromboembolism or intracardiac thrombi in an individual in need of such treatment. A representative method of the present invention comprises the steps of: obtaining a plasma sample from said individual; determining the baseline level of D-dimer in said sample; contacting said... Agent: Georgia Health Sciences University
20120270245 - Diagnosis and risk stratification of infections and chronic diseases of the respiratory tract and lungs by means of provasopressin, particularly copeptin or neurophysin ii: The invention relates to a method for diagnosing and/or stratifying the risk of infections or chronic diseases of the respiratory tract and lungs, particularly lower respiratory tract infections and chronic obstructive pulmonary disease. In said method, provasopressin (proAVP) or fragments or partial peptides thereof, especially copeptin or neurophysin II, is/are... Agent: Brahms Gmbh
20120270244 - Means and methods for diagnosing and/or treating a subject at risk of developing heart failure: The present invention relates to a method for identifying a subject at risk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample of the subject; (b) comparing the level of the biological marker to a standard level of the same... Agent:
20120270246 - Procollagen c-proteinase enhancer (pcpe) biomarker for bone formation: A method of diagnosing fibrosis in a subject is provided, comprising the steps of: determining a level of PCPE in a body fluid sample obtained from said subject; and detecting an increased level of PCPE in said body fluid sample relative to a normal control level of PCPE, wherein said... Agent: Tel Hashomer Medical Research Infrastructure And Services Ltd, The Chaim Sheba Medical Center
20120270247 - Luminescence measurement method and luminescence measurement system: Disclosed is a luminescence measuring method which can produce a luminous intensity depending on the amount of a substance to be measured even when the substance occurs in a biological sample in an amount equal to or more than a given amount, and which can achieve quantitative measurement. The method... Agent: Olympus Corporation
20120270248 - Detection of bacteria in biological fluids: A method for detecting bacteria in biological fluids is provided, the method comprising placing a biological fluid possibly containing bacteria in a container, the container including a detergent for reducing the respiration of blood cells, and a bacterial growth promoter, and measuring and/or detecting the level of glucose in the... Agent: Pall Corporation
20120270249 - Medium for the specific detection of resistant microorganisms: A method for distinguishing among a first group of microorganisms, belonging to a first taxon of bacteria that is vancomycin resistant; a second group of microorganisms, belonging to a second taxon of vancomycin resistant bacteria that is different than said first taxon; and a third group of microorganisms that is... Agent: Biomerieux
20120270250 - Test system for measuring mest activity as well as methods and uses involving the same: The present invention relates to a test system for measuring MEST activity, a method for screening for a ligand for MEST and the use of the test system for the identification of a MEST ligand, particularly a MEST inhibitor.... Agent: Sanofi
20120270251 - Inhibition of the activity of kinase and synthetase enzymes: The invention provides a method of inhibiting the activity of a kinase or a synthetase, the method including binding an active site of the kinase or synthetase with a deuterated imidazole moiety, thereby inhibiting the activity of the kinase or the synthetase.... Agent: Csir
20120270252 - Medium for the specific detection of resistant microorganisms: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of... Agent: Biomerieux
20120270253 - Method for preparing maltogenic alpha-amylase variants: The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties., e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an... Agent: Novozymes A/s
20120270254 - Method for analyzing secretome, biomarker for lung cancer metastasis, and sirna compound for inhibiting lung cancer metastasis: A method for analyzing secretome, a biomarker for lung cancer metastasis, and a siRNA compound for inhibiting lung cancer metastasis are disclosed. The method for analyzing secretome of the present invention comprises the following steps: (A) collecting proteome secreted from a cell; (B) providing a purification gel, wherein the purification... Agent: National Cheng Kung University
20120270255 - Methods for isolating and quantifying antigen from vaccines: The disclosure relates to the development of improved methods for quantifying antigen in a vaccine composition in the absence of available antigen standards. More specifically, the disclosure provides fast and robust methods of separating antigens from vaccine compositions, comprising the steps of solubilizing antigen without detergent and without alkylation, using... Agent: Baxter International Inc.
20120270259 - Fish cancer model: The present invention is directed to fish whose genome has integrated therein an oncogenic nucleic acid operably linked to a promoter. Methods of making the fish and methods for their use are also provided. The fish may advantageously be utilized in methods of screening for drugs or agents that modulate... Agent: Temasek Life Sciences Laboratory Limited
20120270258 - Methods and kits for detecting hemoglobin in test samples: The present invention relates to methods of detecting hemoglobin in a test sample. These methods can be used to diagnose a subject suffering from a genetic disorder relating to hemoglobin metabolism, to determine the eligibility of a subject to be a blood donor, to determine the age of a stored... Agent: Abbott Laboratories
20120270260 - Methods of developing terpene synthase variants: The present disclosure relates to methods of developing terpene synthase variants through engineered host cells. Particularly, the disclosure provides methods of developing terpene synthase variants with improved in vivo performance that are useful in the commercial production of terpene products. Further encompassed in the present disclosure are superior terpene synthase... Agent: Amyris, Inc.
20120270257 - Observation cell arrangement: An observation cell arrangement for flow perfusion of a sample to be examined, the arrangement comprising a flow cell (21) having a cavity therein to receive the sample, the flow cell (21) arranged to receive a flow of fluid through the cavity that is directed over the sample from a... Agent:
20120270256 - Two-photon endoscopic scanning assembly for inflammatory disease detection: An endscopic imaging device is described that achieves longitudinal axis (z-axis) scanning into a tissue or sample, using a piezoelectric microactuator. In some configurations, additional lateral (xy-plane) scanning is also achieved, to allow for the creation of full three-dimensional imaging, ex vivo or in vivo. The techniques may be used... Agent: The Regents Of The University Of Michigan
20120270261 - Analytical instrument and method for evaluating microbial contamination of an object: An instrument and method for ascertaining a viable aerobic microbe count at to employing a two-point calibration curve of tthreshold to TVC for each type of sample. One point on the calibration curve is the x-intercept value (i.e., an estimated or experimental value for the logarithm of the minimum viable... Agent:
20120270262 - Methods for mobile zinc measurement: This invention relates to a method for using a zinc sensor compound to detect a disease associated with the disruption of zinc homeostasis, such as prostate cancer. The zinc sensor compound comprises an optical reporter having two or more recognition units where each of the recognition units is capable of... Agent: The General Hospital Corporation
20120270263 - Enzyme complex from trichoderma reesei and p. funiculosum enzymes: The invention relates to an improved enzyme complex having a plurality of enzyme activities of an expression product obtained by fermentation of the genus Trichoderma in combination with one or more enzymes of a different fungus strain.... Agent: Danisco A/s
20120270264 - Dna construct, and process for production of recombinant cho cell using same: Disclosed is a DNA construct that is useful for efficient production of recombinant CHO cells useful for the production of target proteins. The DNA construct is a construct comprising, from a 5′ end toward a 3′ end, a first homologous DNA fragment, a target protein gene, and a second homologous... Agent: Toto Ltd.
20120270267 - Alpha-amylases: The present invention relates to alpha-amylase variants, polynucleotides encoding the variants and nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes.... Agent: Novozymes A/s
20120270268 - Anti-cd100 neutralizing antibodies and methods of using the same: Compositions and methods are provided for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers. In particular, anti-CD100 monoclonal antibodies have been developed to neutralize CD100.... Agent: Vaccinex, Inc.
20120270265 - Methods of obtaining a specific binding member that binds eotaxin: Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralise eotaxin-1 activity. The antibodies VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT 213. One or more complementary determining... Agent: Medimmune Limited
20120270266 - Nucleic ac1d and amino ac1d sequences encoding high-level expressor factor viii polypeptides and methods of use: Methods and compositions are provided that allow for high-level expression of a factor VIII polypeptide. More specifically, methods and compositions are provided comprising nucleic acid and amino acid sequences comprising a modified factor VIII that result in high-level expression of the polypeptide. The methods and compositions of the invention find... Agent: Expression Therapeutics LLC
20120270269 - Organic solvent pretreatment of biomass to enhance enzymatic saccharification: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of ammonia and optionally an additional nucleophile to fragment and extract lignin without loss of hemicellulose. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for the... Agent: E I Du Pont De Nemours And Company
20120270270 - Variant humicola grisea cbh1.1: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are... Agent: Danisco US Inc.
20120270271 - Toxin-immunity system: The present invention provides host cells whose survivability can be conditionally controlled, and vectors that can be used for preparing such host cells and for selectable cloning.... Agent: University Of Washington
20120270272 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the... Agent: Cornell Research Foundation, Inc.
20120270273 - Transcription activator-like effectors: Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides.... Agent: President And Fellows Of Harvard College
20120270274 - Mannose-6-phosphate isomerase, mutant thereof, and use thereof: New mannose-6-phasphate isomerase, mutant enzyme thereof, and a method of producing L-ribose using the enzyme are provided, and more specifically, mannose-6-phosphate isomerase, mutant enzyme thereof, recombinant expression vectors including relevant genes, microorganisms transformed with the vectors, a method of producing mannose-6-phosphate isomerase or mutant thereof in bulk using them, and... Agent: Konkuk University Industrial Cooperation Corp.
20120270277 - Biomass hydrolysis process: The invention relates to a biomass process comprising split dosage of the cellulose hydrolysing enzyme.... Agent: Novozymes A/s
20120270276 - Method for producing saccharides containing glucose as main components: Provided is a method for producing saccharides containing glucose as the main components which can increase the generated amount of saccharides containing glucose as the main components even when an enzymatic saccharification reaction is performed with a small amount of enzyme. A method for producing saccharides containing glucose as the... Agent: Jgc Corporation
20120270275 - Systems and methods for treating biomass and calculating ethanol yield: The present invention provides processes, inter alia, for the treatment of a starch-based feedstock. The processes include mixing together a starch-based feedstock and a working fluid to form a slurry, hydrating the starch-based feedstock with the working fluid, adding an enzyme to the slurry, pumping the slurry into a substantially... Agent:
20120270278 - Compositions and methods for production of fermentable sugars: The present application provides genetically modified fungal organisms that produce enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to glucose, enzyme mixtures produced by the genetically modified fungal organisms, and processes for producing glucose from cellulose using such enzyme mixtures.... Agent: Codexis, Inc.
20120270281 - Bioreactor performance in the production of monatin: Methods and systems for increasing the production of monatin in a multi-step equilibrium pathway are described. Tryptophan and pyruvate are added to a bioreactor to form a mixture comprising monatin and a plurality of intermediates via a multi-step equilibrium pathway. The methods and systems include operating the bioreactor such that... Agent: Cargill, Incorporated
20120270279 - Method for producing monatin: The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin... Agent: Ajinomoto Co. Inc
20120270280 - Preparation of beta-amino acids: The present invention relates to a process for the biocatalytic, enantioselective production of a β-amino acid pre-cursor from an optionally substituted dihydrouracil using a hydantoinase and/or a dihydropyrimidinase, a process for producing a β-amino acid from said precursor, a hydantoinase and its use in said process for the biocatalytic production... Agent: Basf Se
20120270282 - Penicillin-g acylases: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.... Agent: Codexis, Inc.
20120270283 - Enzyme interesterification process: A fatty material enzyme interesterification process comprising the steps of: a) providing a fatty material that has optionally undergone at least one prior purification treatment; b) introducing soap into said fatty material to form a soap-containing fatty material mixture, c) homogenising said soap-containing fatty material mixture by mixing, d) contacting... Agent: Desmet Ballestra Engineering S.a.
20120270284 - Method and system for robotic algae harvest: A Robotic Algae Harvester (RAH) of the present invention works by providing a CO2 collection mechanism that is installed in power plants or vehicles. These systems are available using current technology and have been proven to be scalable. CO2 is then transported to RAH using ships. The RAH will feed... Agent:
20120270285 - Stereospecific carbonyl reductases: Stereospecific carbonyl reductases SCR1, SCR2, and SCR3 are described herein as are nucleotide sequences that encode these reductases. These stereospecific carbonyl reductases have anti-Prelog selectivity and have specificities that are useful for fine biochemical synthesis.... Agent:
20120270286 - Hollow fiber membrane module for use in production of chemical substance, and process for production of chemical substance: A hollow fiber membrane module for use in production of a chemical substance, which is used in continuous fermentation including filtering a fermentation broth of a microorganism or a cultured cell through a hollow fiber membrane, collecting a chemical substance from a filtrate, retaining a concentrated solution in the fermentation... Agent: Toray Industries, Inc.
20120270287 - Novel method of producing 3-hydroxypropionic acid from glycerol: The present invention relates to a novel method of producing 3-hydroxypropionic acid from glycerol, and more particularly to a method of producing 3-hydroxypropionic acid by culturing in a glycerol-containing medium a mutant microorganism obtained by amplifying an aldehyde dehydrogenase-encoding gene in a microorganism having the abilities to produce coenzyme B12... Agent: Korea Research Institute Of Bioscience And Biotechnology
20120270288 - Process to produce organic compounds from synthesis gases: At least one isolated microorganism and a fermentation method to convert hydrogen gas, carbon dioxide gas, and/or carbon monoxide gas to a lower alkyl alcohol and/or carboxylic acid and to produce at least 2% by volume of the lower alkyl alcohol or carboxylic acid in an aqueous-based medium.... Agent:
20120270289 - Co-fermentation of glucose, xylose and/or cellobiose by yeast: Provided herein are methods of using yeast cells to produce ethanol by contacting a mixture comprising xylose with a Spathaspora yeast cell under conditions suitable to allow the yeast to ferment at least a portion of the xylose to ethanol. The methods allow for efficient ethanol production from hydrolysates derived... Agent: Wisconsin Alumni Research Foundation
20120270290 - Pentose transporter: Disclosed is the production of useful substances such as bioethanol from pentose through effective use of biomass resources. Specifically, the invention discloses the following: Use of HGT2 gene or an expression product protein thereof as a xylose transporter. A xylose and/or L-arabinose transporter as an expression product protein of a... Agent: Kyoto University
20120270291 - Topical compositions comprising fermented extracts of traditional chinese medicinal (tcm) ingredients, and methods of making and using same: The present invention relates to topical compositions containing fermented extracts of Traditional Chinese Medicinal (TCM) ingredients for improving the appearance and skin condition of the user. The topical compositions of the present invention are tailored for different users of different skin compositions according to TCM principles. The fermented TCM extracts... Agent:
20120270292 - Photo-inactivated viruses and systems and methods of using the same: The present disclosure relates generally to systems and methods for the photo-inactivation of microorganisms. More specifically, the present invention is directed towards the photo-inactivation of microorganisms, such as viruses, using at least one furanocoumarin and broad spectrum pulsed light. For example, an aspect of the present invention includes a method... Agent: Georgia State University Research Foundation
20120270293 - Standardization of tissue specimen preservation by ultrasound and temperature control: A tissue sample preservation process and device for improving and standardizing tissue preservation procedure, including placing tissue specimens in a cold fixative, performing fixative penetration at a refrigerated temperature, and accelerating fixative penetration by ultrasound. Also disclosed is the application of ultrasound and temperature control in the dehydration, clearing, and... Agent:
20120270294 - Stem cell capture and immobilization coatings for medical devices and implants: Constructs and methods for immobilizing stem and other precursor cells, as well as other bioactive materials of therapeutic value on the surfaces of medical devices, such as bone, cartilage, spinal and tooth implants, are described herein. The present invention has broad application in the incorporation of bioactive and therapeutic materials... Agent: Bioactive Surgical, Inc.
20120270295 - Nested cell encapsulation: The invention relates to a method for encapsulating living cells and labels, as well as encapsulated labelled cells and kits for performing such encapsulation. The encapsulated cells may be useful in multiple parallel tissue culture experiments, where the labels in each microcapsule may be used to decipher a cells path... Agent:
20120270296 - Isotope-doped nano-structure and isotope labeled structure using the smae: An isotope-doped nano-structure is provided. The isotope-doped nano-structure includes at least one isotope-doped nano-structure segment having at least two isotopes of the element. The at least two isotopes of the element are mixed uniformly in a certain proportion. The isotope-doped nano-structure can be used for isotope labeling one type of... Agent: Tsinghua University
20120270297 - Culturing and genetic manipulations of thermotoga spp.: Described herein is the creation and use of Thermotoga-E. coli shuttle vectors; an embedded cultivation method that greatly simplifies the cultivation methods for Thermotoga previously used; and the subcloning, characterization, and use of a Thermotoga Restriction-modification system.... Agent: Bowling Green State University
20120270298 - Novel variant hyprocrea jecorina cbh1 cellulases: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.... Agent: Danisco US Inc.
20120270300 - Production of recombinant factor ix in a human hepatocyte cell line: The invention relates to a recombinant human factor IX (FIX) characterized in that said factor is obtained by a preparation method comprising, or even consisting of, the steps which consist in causing the genetic material encoding the FIX to be expressed in vitro in a human hepatocyte cell line Huh7,... Agent: Universite Claude Bernard Lyon I
20120270299 - Tissue plasminogen activator variant uses: A method is disclosed for using tenecteplase to restore function in dysfunctional hemodialysis catheters, which have a blood flow rate of less than 300 mL/minute. Kits are also provided with instructions to direct the user to administer tenecteplase in a total dose of about 3 to 4 mg locally into... Agent: Genentech, Inc.
20120270301 - Proteins with repetitive bacterial-ig-like (big) domains present in leptospira species: The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3... Agent: The Regents Of The University Of California
20120270302 - Method for making dehydrated mycelium elements and product made thereby: A living hydrated mycelium composite containing at least one of a combination of mycelium and fibers, mycelium and particles, and mycelium, particles and fibers is processed with a nutrient material to promote mycelia tissue growth; thereafter dehydrated to a moisture content of less than 50% by weight to deactivate the... Agent:
20120270303 - Manufacturing method of high content of starch from microalgae: The present invention provides a medium for culturing microalgae comprising NaNO3, K2HPO4, MgCl2.6H2O, Na2CO3, CaCl2, ethylene diamine tetraacetate, citric acid and Na2SiO3.9H2O or ferric citrate. The medium of the present invention can be used for culturing microalgae with high content of starch, and thus biomass materials can be obtained at... Agent: Hyundai Motor Company
20120270304 - Photo-bioreactor system and method: Systems and methods for cultivating photoautotrophic microorganisms are described. The systems and methods include a photo-bioreactor system and method for growing and harvesting algae in a mass production environment.... Agent: Arizona Technology Innovation Group, L.L.C.
20120270306 - Method and apparatus for rapidly counting and identifying biological particles in a flow stream: A method for increasing the throughput and/or the precision of a flow cytometer, or a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer. The system and method includes utilizing the technique of laser rastering in combination with a lysis-free single-dilution... Agent: Abbott Laboratories
20120270305 - Systems, methods, and apparatuses to image a sample for biological or chemical analysis: A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device... Agent: Illumina Inc.
20120270307 - Biogas desulfurization device: A biogas desulfurization device comprises an anaerobic system, a desulfurization liquid circulating system, an oxygen supply device and a desulfurization system, wherein the anaerobic system is used for generating biogas and filling the generated biogas into the desulfurization system, the desulfurization liquid circulating system is used for filling the desulfurization... Agent: Beijing Helee Bio-energy Technology Co., Ltd.
20120270308 - Pressing arrangement for a cover, in particular in a laboratory apparatus, and method for pressuring by using a pressing arrangement: The invention relates to a pressing arrangement for a cover, in particular in a laboratory thermostat, having at least: a first component disposed to exert an excitation force, a second component, in particular a plate component disposed to exert a pressing force Fz in at least one target position, a... Agent: Eppendorf Ag
20120270309 - Thermal cycler: A thermal cycler for incubating reaction mixture, the thermal cycler including:(1) a heat block for holding and heating reaction containers which contain the reaction mixture, the heat block being a double-layered structure of a lower layer heat block and an upper layer heat block; and (2) a thermal control means... Agent: Takara Bio Inc.
20120270310 - Apparatus for transfer of liquid for processing samples: An apparatus for transfer of a liquid using a diaphragm that separates a working fluid volume from a working air volume and can controllably induce a change pressure to draw or expel a target fluid into a tube. The apparatus is particularly suitable for automated processing of nucleic acids and... Agent:
20120270311 - Female specific insect expression system: The present invention provides an insect expression system that may be used to provide biological control of pest insects and control transmission of infectious diseases transmitted to the human population by insects.... Agent: Board Of Trustees Of The University Of Arkansas
20120270312 - Device and method for biological sample purification and enrichment: A device for sample purification and enrichment comprising a filtration unit having a filter and an agitator, wherein suction draws a sample across the filter and a back wash flushes materials collected in the filter. The amount of collected material in the filter is determined by a pressure measurer controlling... Agent: Liquid Biopsy Ab
20120270313 - Compositions and methods for establishing and maintaining stem cells in an undiffferentiated state: The present invention embraces compositions and methods for establishing and maintaining stem cells and inhibiting stem cell differentiation using a selective Protein Kinase C (PKC) inhibitor.... Agent: University Of Kansas
20120270315 - Methods and means for obtaining modified phenotypes: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells, particularly in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated target-specifc RNA is provided by transcription of a chimeric gene... Agent: Commonwealth Scientific And Industrial Research Organisation
20120270314 - Non-tumorigenic expansion of pluripotent stem cells: A method for expansion of human embryonic stem (hES) cells in a medium including human umbilical cord-derived mesenchymal stem cells (HUCMSCs) as a feeder is provided. The human embryonic stem cells (hES) maintain the features of embryonic stem cells in the medium, such as pluripotency, unlimited undifferentiated proliferation and normal... Agent: Buddhist Tzu Chi General Hospital
20120270316 - Methods and reagents for preserving rna in cell and tissue s amples: This specification relates to the field of molecular biology and provides novel methods and reagents for preserving and protecting the ribonucleic acid (RNA) content of samples from degradation prior to RNA isolation. This preservation may be accomplished without ultra-low temperature storage or disruption of the tissue.... Agent: Applied Biosystems, LLC
20120270317 - Alternative export pathways for vector expressed rna interference: The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules.... Agent:
20120270318 - Ion channel modulators and methods of use: In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.... Agent: Vertex Pharmaceuticals Incorporated
20120270319 - Amnion-derived cell compositions, methods of making and uses thereof: The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived... Agent:
20120270320 - Culture medium and manufacturing method thereof: A culture medium for growing at least one kind of cells is provided. The culture medium includes a carbon nanotube structure and a cell adhesion layer. The cell adhesion layer covers one surface of the carbon nanotube structure. The at least one kind of cells grows on the cell adhesion... Agent: Tsinghua University
20120270321 - Reverse genetics systems: The invention provides various reverse genetics systems for producing segmented RNA viruses, wherein the systems do not require bacteria for propagation of all of their expression constructs.... Agent: Novartis Ag
20120270322 - Shuttle vectors for mycobacteria-escherichia coli and uses thereof: The present disclosure provides a DNA molecule capable of replication in Mycobacteria having a nucleic acid sequence as disclosed in SEQ ID NO: 1, a shuttle vector constructed using it and a transformed cells containing the present vector. The vector of about 18 kb of the present disclosure contains 16... Agent: Snu R&db Foundation
20120270323 - Compositions and methods for altering alpha- and beta-tocotrienol content: Preparation and use of isolated nucleic acids useful in altering the oil phenotype in plants. Isolated nucleic acids and their encoded polypeptides that alter alpha- and beta-tocotrienol content in seeds and oil obtained from the seeds. Expression cassettes, host cells and transformed plants containing the foregoing nucleic acids.... Agent: E I Du Pont De Nemours And Company10/18/2012 > 116 patent applications in 73 patent subcategories.
20120264103 - Compositions and method for tissue preservation: Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.... Agent: Unite States Government As Represented By The Department Of Veterans Affairs Office Of
20120264104 - Method for the hypothermic perfusion of a cardiac organ, and device for the implementation thereof: The present invention relates to a method and device for the hypothermic perfusion of a cardiac organ. According to the invention, the infusion device comprises: a. a first sealed tank (2) that is capable of containing a physiological liquid (LP); b. a second sealed tank (3) that is in communication,... Agent: Universite Claude Bernard Lyon 1
20120264105 - Composition for preserving reproductive cells and method of using: Disclosed are compositions for mammalian, avian or piscian reproductive cells and methods for the collection, holding, processing, in vitro fertilization, sexing culturing, or storing (including long-term cryopreservation) of mammalian or avian reproductive sperm cells. The compositions comprise suitable reproductive cell media and antioxidant bioflavonoids. These may be comprised of Oligomeric... Agent:
20120264106 - Novel methods for modulating inflammatory and/or immune responses: The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as... Agent:
20120264107 - Real time monitoring of microbial enzymatic pathways: This invention provides compositions and methods for monitoring and regulating the production of a target product of a biochemical pathway in an organism, such as butanol. A gene encoding a light-emitting reporter molecule, such as luciferase, is operatively linked with a transcription regulatory nucleotide sequence that regulates transcription of an... Agent:
20120264110 - Automated pap screening using a plurality of biomarkers and multi-spectral imaging: An automated screening method for detecting abnormalities in a sample. The method includes steps of staining a sample with a histologic or cytologic stain for transmission light microscopy to provide a stained sample; exposing the stained sample to a plurality of differentially-labeled biomarkers, wherein each of the biomarkers is labeled... Agent:
20120264114 - Disposable device for the detection of particles of interest, such as biological entities, detection system comprising said device and method for using same: The invention relates to a disposable device comprising all of the reagents necessary for the detection of one or more particles of interest, and which can be incorporated in a detection system including simple means for the automatic management of fluids. For this purpose, the invention relates to a disposable... Agent: Centre National De La Recherche Scientifique
20120264111 - Hydrophobic, functionalized particles: The present invention relates to a stable mixture comprising surface-modified particles which are obtained by reacting metal oxide or semimetal oxide particles with at least one compound selected from among silicon-comprising compounds bearing at least one metaloxy radical and optionally further alkoxy and/or hydroxy radical(s) and at least one solvent,... Agent: Basf Se
20120264108 - Intracellular molecular delivery based on nanostructure injectors: There is disclosed a method and device for the delivery of molecules into individual cells. A device for injecting a biological molecule into a target cell comprises a microscopic tip attached to a mechanical scanning device for positioning the tip relative to the target cell and for moving the tip... Agent: The Regents Of The University Of California
20120264109 - Lymphocyte analysis for monitoring the progression of immunodeficiency virus: The present disclosure describes a method of monitoring disease progression in a mammal positive for immunodeficiency virus which includes collecting blood cells from a mammal to obtain a first blood sample adding antibodies such as CD4 and CD8 to the first blood sample scanning the blood sample to produce a... Agent: Idexx Laboratories, Inc.
20120264112 - Method of measuring human cyp3a inducibility: A method for measuring human CYP3A inducibility upon administration of a test drug, characterized in that a non-human animal to which a test drug is administered or a population of human cells cultured in a medium containing a test drug is infected with viruses (A) and (B); virus (A) being... Agent: Daiichi Pure Chemicals Co., Ltd.
20120264113 - Use of superhydrophobic surfaces for liquid agglutination assays: This invention relates to the use of thermodynamically incompatible surfaces in agglutination assays for the express purpose of using the sample as a key component of the detection instrument. Specifically, the invention relates to formation of a lense and a virtual container for rapid mixing via thermal energy by a... Agent:
20120264117 - Method for purification and identification of sperm cells: The present disclosure describes the isolation, identification and purification of aptamers having sufficiently high affinity and specificity to capture and immobilize intact sperm cells in the presence of female epithelial cells and other non-sperm semen components. The present disclosure also describes affinity-based methods for the detection of sperm cells in... Agent: Somalogic, Inc.
20120264116 - Methods and apparatus for point-of-care nucleic acid amplification and detection: Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for... Agent:
20120264115 - Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies: The present invention provides a method capable of detecting single or multiple fetal chromosomal aneuploidies in a maternal sample comprising fetal and maternal nucleic acids, and verifying that the correct determination has been made. The method is applicable to determining copy number variations (CNV) of any sequence of interest in... Agent: Artemis Health, Inc.
20120264118 - Quantitation of cellular dna and cell numbers using element labeling: Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a... Agent: Dvs Sciences, Inc.
20120264130 - Corn event mir162: A novel transgenic corn event designated MIR162 is disclosed. The invention relates to nucleic acids that are unique to event MIR162 and to methods for detecting the presence of the MIR162 event based on DNA sequences of the recombinant constructs inserted into the corn genome that resulted in the MIR162... Agent: Syngenta Participations Ag
20120264123 - Extracellular serine protease: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of... Agent: Board Of Trustees Of The University Of Arkansas
20120264129 - K-ras mutations and anti-egfr antibody therapy: The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors.... Agent:
20120264128 - Method for qualitative and quantitative detection of common wheat: Disclosed are: a method for detecting common wheat among from wheat varieties contained in a sample of interest such as a food raw material or a processed food specifically, with high sensitivity, and in a qualitative and/or quantitative manner; a method for discriminating between common wheat and a wheat variety... Agent: Nippon Flour Mills Co., Ltd
20120264122 - Methods and compositions for nucleic acid amplification: Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specifically to a target sequence that is amplified and a universal (U) sequence that is introduced... Agent: Gen-probe Incorporated
20120264126 - Methods for the diagnosis of bacterial vaginosis: The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or... Agent: Quest Diagnostics Investments Incorporated
20120264124 - Microsatellite marker combination and method for identifying lanyu pig breed: The present invention provides a microsatellite marker combination for identifying Lanyu pig breed, and the identification method thereof. The identification method comprises the following steps: (a) providing a genomic DNA sample obtained from a pig; (b) identifying the polymorphism of microsatellite markers of said genomic DNA sample; and (c) analyzing... Agent:
20120264119 - New method for decontamination and processing of clinical specimens from a patient: The present invention relates to a new method for decontaminating and processing clinical samples suspected of containing Mycobacteria. In this method the clinical samples are processed in a solution comprising a hypochlorite salt and N-acetyl cysteine.... Agent:
20120264121 - Resolving genome fractions using polymorphism counts: Methods of reliably estimating genomic fraction (e.g., fetal fraction) from polymorphisms such as small base variations or insertions-deletions are disclosed. Sequenced data from a multigenomic source is used to determine allele counts for one or more of the polymorphisms. For one or more of the polymorphisms, zygosity is assigned, and... Agent: Verinata Health, Inc.
20120264125 - Screening method for trinucleotide repeat sequences: A method for screening for a trinucleotide repeat sequence in a biological sample is provided. The method comprises the step of contacting a nucleic acid sequence obtained or derived from the biological sample under amplification conditions with i) a first primer having a target sequence in a region 3′ or... Agent: National University Of Singapore
20120264127 - Simultaneous detection of mutational status and gene copy number: The present invention provides compositions and methods for simultaneously detecting mutational status and gene copy number. In particular, the present invention provides simultaneous measurement of gene copy number and detection of the L858R and Exon 19 del mutations in a tissue sample.... Agent:
20120264120 - Specimen for detecting infiltrative large intestine tumors: The present invention is characterized in that it enables to obtain a specimen that can be used to detect invasive colorectal tumors by spraying a washing fluid onto the colonic mucous layer of a subject to detach the mucus from the mucous layer, and collecting the detached mucus together with... Agent: Sapporo Medical University
20120264132 - Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes: Provided are devices and methods for effecting processing of samples, including essentially isothermal amplification of nucleic acids, at multiple reaction locations in a single device. In some embodiments, the disclosed devices and methods provide for effecting parallel sample processing in several hundred locations on a single device.... Agent:
20120264131 - Changes in the expression of mir-200c/141 cluster of micrornas as biomarkers for epithelial-to-mesenchymal transition in human colorectal cancer metastasis: The present invention includes methods, kits and biomarkers for detecting and determining the development of colorectal cancer (CRC) metastasis based on changes in the expression pattern of one or more microRNAs (miR) or miR clusters that include the miR-200/141 family.... Agent: Baylor Research Institute
20120264133 - Lateral flow nucleic acid detector: Point-of-care binding assays include at least one target nucleic acid binding in a multiplex structure with at least one sequence in a partner nucleic acid associated with a label, due to complementary base pairings between at least one sequence in the target nucleic acid and at least one sequence in... Agent: Rapid Pathogen Screening, Inc.
20120264134 - Methods and apparatus for the manipulation of particle suspensions and testing thereof: Apparatus and methods are provided for analysis of individual particles in a microfluidic device. The methods involve the immobilization of an array of particles in suspension and the application of experimental compounds. Such methods can also include electrophysiology studies including patch clamp recording, electroporation, or both in the same microfluidic... Agent: Fluxion Biosciences Inc.
20120264135 - Method of detecting coccidioides species: The present invention provides methods and kits that may be used to detect and quantify the presence of Coccidioides species. The methods include quantification PCR assays, and the kits and compositions include oligonucleotides used as primers and probes.... Agent: Translational Genomics Research Institute
20120264136 - Methods of detecting charcot-marie tooth disease type 2a: Methods are described for screening a subject for risk of Charcot-Marie-Tooth Disease Type 2A or for diagnosing Charcot-Marie-Tooth disease or a predisposition for developing Charcot-Marie-Tooth disease in a subject, by detecting the presence or absence of a mutation in the mitofusin gene in a biological sample collected from the subject.... Agent: Duke University
20120264137 - Techniques for bufferless lysing of cells and separation of cellular components using modified membranes: A porous membrane for lysis of a cell population enriched from a biological sample, and isolation of cellular components is provided. The porous membrane contains embedded lysing agents to perform lysing. The biological sample is brought into contact with the membrane. Lysis occurs through the action of the embedded lysing... Agent: Indian Institute Of Science
20120264140 - Methods and kits to detect and monitor ovarian cancer and preeclampsia: The present invention provides methods and kits related to a prognostic, and, in certain embodiments, diagnostic indicator for ovarian cancer which comprises measuring the level of MUC16 bound to immune cells. The level of MUC16 bound to immune cells can by itself be an indicator of disease regression or recurrence,... Agent: Wisconsin Alumni Research Foundation
20120264142 - Detection of b-cell activating factor as a biomarker for antibody mediated rejection in transplant recipients: The invention relate to methods, compositions, and kits for detection of biomarkers. hi one embodiment, the invention relates to a method for detecting AMR biomarkers in a biological sample. In another embodiment, the invention relates to a method for detecting, monitoring, diagnosing and predicting antibody mediated rejection. In yet another... Agent: Wisconsin Alumni Research Foundation
20120264141 - Tuberculosis diagnostic test: A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which... Agent: Isis Innovation Limited
20120264139 - Method for diagnosing acute coronary syndrome: m
20120264138 - Method for diagnosing and monitoring cardiac ischemia in patients with acute chest pain and without myocardial infarction: The present disclosure relates to a method for diagnosing the ischemic state in a subject suffering from acute coronary syndrome who does not fulfilling the diagnostic criteria for a myocardial infarction. The present disclosure also relates to a method for identifying a subject being susceptible to cardiac intervention, wherein the... Agent: Roche Diagnostics Operations, Inc.
20120264145 - Assay for soluble cd200: The disclosure relates to methods for identifying a subject having elevated CD200 levels and/or comprising cells overexpressing CD200, the method comprising the step of assaying a biological fluid from the subject to determine a level of soluble CD200, wherein a level above control indicates the subject has elevated CD200 levels.... Agent: Trillium Therapeutics Inc.
20120264146 - Combination of spla2 activity and lp(a) cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event: The present invention related to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising: -measuring, in a sample obtained from said subject, at least two cardiovascular risk factors: a) s PLA2 activity and b) Lipoprotein(a), -combining said... Agent: Inserm (institut National De La Sante Et De La Recherche Medicale)
20120264143 - Cytokine-like proteins: A full-length cDNA corresponding to an EST (AA418955), which does not show any homology to other proteins in the database but has a weak homology to G-CSF, has been successfully isolated by synthesizing primers based on the EST sequence, and effecting PCR-cloning from a human fetal spleen library. Sequencing of... Agent:
20120264147 - Diagnostic marker for hepatocellular carcinoma comprising anti-fasn autoantibodies and a diagnostic composition for hepatocellular carcinoma comprising antigens thereof: The present invention relates to an autoantibody specifically recognizing the epitope sequence of FASN (fatty acid synthase), more particularly, to the autoantibody or a fragment comprising an antigen-binding site thereof, a diagnostic composition for hepatocellular carcinoma comprising an agent capable of assessing the expression level of the autoantibody, a hybridoma... Agent: Korea Research Institute Of Bioscience And Biotechnology
20120264144 - Method for binding a recombinant polypeptide to a carrier: The present invention refers to a method for binding a recombinant polypeptide to a carrier, wherein a layer is bound to a carrier, and the layer comprises a recombinant polypeptide on the surface distal to the carrier.... Agent: Autodisplay Biotech Gmbh
20120264148 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Dashurin as a diagnostic and prognostic biomarker in renal injuries.... Agent:
20120264149 - Method for the determination of the formation of endothelins for medical diagnostic purposes, and antibodies and kits for carrying out such a method: An in vitro method for the determination of the formation of endothelins in serious diseases, in particular cardiovascular diseases, inflammations, sepsis and cancer, in whole blood, plasma or serum of a human patient for medical diagnostics purposes, in which relatively long-lived peptide fragments of the processed primary prepro- or proendothelins... Agent: B.r.a.h.m.s Gmbh
20120264150 - Detection of restenosis risk in patients receiving a stent by measuring the characteristics of blood clotting including the measurement of maximum thrombin-induced clot strength: Provided is a method of selecting a stent for implantation in the circulatory system of a human being. The method comprises obtaining a blood sample from a patient who requires implantation of a stent and testing said blood sample to determine a platelet coagulability level. The determined platelet coagulability level... Agent:
20120264152 - Diagnostic and prognostic assays based on circulating tyrosine kinase activity: Provided herein are methods for the diagnosis, prognosis, or management of diseases, such as cancer, by measuring the tyrosine kinase activity in acellular body fluids. Further provided are methods of predicting response to therapy in certain populations of cancer patients by contacting an acellular body fluid sample from a patient... Agent: Quest Diagnostics Investments Incorporated
20120264151 - System and method for diagnosing lymphoma in cats: The invention provides a method and a system for diagnosing lymphoma in cats. The system allows a care giver to measure the enzymatic activity of thymidine kinase in a blood sample. The invention teaches that when the enzymatic activity of thymidine kinase in the blood stream of a cat is... Agent:
20120264153 - Method of detecting phytase activity or protease activity: A method of detecting a phytase activity or a protease activity is described. The method comprises the steps of: (a) providing a composition comprising a phytate/protein complex in a liquid or a gel; wherein the phytate/protein complex provides a detectable property to the composition; (b) providing a sample that comprises... Agent: Danisco A/s
20120264157 - Anionic acid-labile surfactants and methods of use: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile... Agent: Protea Biosciences, Inc.
20120264158 - Anionic acid-labile surfactants and methods of use: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile... Agent: Protea Biosciences, Inc.
20120264156 - Method for characterizing at least one microorganism by means of mass spectrometry: The present invention relates to a method for characterizing at least one microorganism from a sample, said method including identifying said at least one microorganism and determining the properties of typing, potential resistance to at least one antimicrobial, and virulence factor, characterized in that determining the properties of typing, resistance... Agent: Biomerieux, Sa
20120264154 - Method for quantifying biomolecules: The present invention relates to a method that allows comprehensive quantitation of one or a plurality biomolecules, including the entire complement of biomolecules in a sample by comparing their quantity to the quantity of reference biomolecules in a standard mixture obtained via extraction from at least two different cell populations.... Agent:
20120264155 - Multiplex quantitation of individual recombinant proteins in a mixture by signature peptides and mass spectrometry: The present invention relates to an analytical method for quantitation of selected multiple recombinant proteins in a complex matrix such as recombinant polyclonal antibodies in serum or recombinant polyclonal antibodies expressed in a culture supernatant.... Agent: Symphogen A/s
20120264161 - Mhc peptide complexes and uses thereof in infectious diseases: Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of... Agent: Dako Denmark A/s
20120264160 - Revolving cell culture cartridge and methods of use: A cell culture device and system can be used for high throughput biological assays to study the biological effect of a test substance. The device and system can include a revolving cartridge having a body including a center aperture and two or more evenly spaced sample wells that are spaced... Agent: Empire Technology Development LLC
20120264159 - Screening system for modulators of her2 mediated transcription and her2 modulators identifed thereby: This invention pertains to the development of a screening system to identify (screen for) HER2 promoter silencing agents. Such agents are expected to be of therapeutic value in the treatment of cancers characterized by HER2 amplification/upregulation. In addition, this invention pertains to the discovery that histone deacetylase (HDAC) inhibitors like... Agent: Buck Institute For Age Research
20120264162 - Mass spectrometric measurement of microbial resistances: Microorganisms, particularly bacteria, are identified and characterized on the basis of a mass spectrometric measurement of their protein profiles with ionization by matrix-assisted laser desorption. In order to measure the microbial resistance to antibiotics, the protein profiles of microorganisms are measured after cultivation for a short time duration in nutrient... Agent: Bruker Daltonik Gmbh
20120264163 - Apparatus and method for detecting bacterial growth beneath a wound dressing: An apparatus and method are provided for visually monitoring, detecting, and/or determining the presence, absence, and/or growth of harmful or potentially harmful bacterial microorganisms beneath a wound dressing, in one example used to cover an indwelling central venous catheter or other catheter. A bacteria detection apparatus includes a barrier membrane,... Agent: Indicator Systems International, Inc.
20120264164 - Lymph node specimen collection kit and method of pathological analysis for lung cancer diagnosis using such a kit: A unique system for the correlation between removed lymph nodes for lung cancer diagnosis and pathological analysis thereof is provided. Such a system includes the removal of certain lymph nodes from a suspected or known lung cancer patient with subsequent categorization thereof and placement within a properly divided and labeled... Agent:
20120264165 - Method of detecting tumor cells by fluorescence signals: The invention relates to a method of detecting dividing cells, or cells having the potential of dividing, in a cytological specimen stained using a Papanicolaou staining process, by the detection of a fluorescence signal coming from the membranes of these cells.... Agent: Universite Paris-sud
20120264166 - Multifunctional biomaterials as scaffolds for electronic, optical, magnetic, semiconducting, and biotechnological applications: One-dimensional ring structures from M13 viruses were constructed by two genetic modifications encoding binding peptides and synthesis of a heterobifunctional linker molecule. The bifunctional viruses displayed an anti-streptavidin peptide and hexahistidine (SEQ ID NO:4) peptide at opposite ends of the virus as pIII and pIX fusions. Stoichiometric addition of the... Agent: Board Of Regents, The University Of Texas System
20120264167 - Novel ginsenoside glycosidase derived from the genus terrabacter, and use thereof: The present invention relates to a novel ginsenoside glycosidase protein derived from the genus Terrabacter, the protein having an activity of converting protopanaxadiol (PPD)-type saponins into highly active substances, which can be absorbed inside the body, by selective hydrolysis of a particular bond of ginsenoside. More specifically, the present invention... Agent: Korea Research Institute Of Bioscience And Biotechnology
20120264169 - Dnase expression in recombinant host cells: e
20120264168 - Zcytor17 heterodimeric cytokine receptor polynucleotides: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and... Agent: Zymogenetics, Inc.
20120264170 - Cell line 3m: The present invention provides, inter alia, an isolated cell line, 3M as well as methods for making such a cell line and methods of using such a cell line, e.g., to produce a protein such as an immunoglobulin.... Agent:
20120264171 - Stabilization of alpha-amylases towards calcium depletion and acidic ph: The present invention relates to variants of a parent alpha-amylase, the variant having improved stability or activity at low calcium conditions or at low pH.... Agent: Novozymes A/s
20120264172 - Protein from photobacterium damselae and use thereof: A derivative of a 55 kDa extracellular protein from Photobacterium damselae subsp. piscicida is the basis for a vaccine against Photobacterium infection, and thereby protects fish from pasteurellosis.... Agent: Novartis Ag
20120264173 - Organic solvent pretreatment of biomass to enhance enzymatic saccharification: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of one or more alkylamine and optionally one or more additional nucleophile to fragment and extract lignin. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for... Agent: E I Du Pont De Nemours And Company
20120264174 - Assay for vitamin b12 absorption and method of making labeled vitamin b12: The invention provides methods for labeling vitamin B12 with 14C, 13C, tritium, and deuterium. When radioisotopes are used, the invention provides for methods of labeling B12 with high specific activity. The invention also provides labeled vitamin B12 compositions made in accordance with the invention.... Agent: The Regents Of The University Of California
20120264175 - Thermostable biocatalyst combination for nucleoside synthesis: The present invention relates to a recombinant expression vector comprising: a) the sequence encoding a purine nucleoside phosphorylase (PNPase, E. C. 184.108.40.206), b) the sequence encoding a uridine phosphorylase (UPase, E. C. 220.127.116.11), c) or both; each of the sequences operably linked to one or more control sequences that direct... Agent:
20120264176 - Alpha-amylases: The present invention relates to alpha-amylases, nucleic acids encoding the alpha-amylases, methods of producing the alpha-amylases, and methods of using the alpha-amylases.... Agent: Novozymes A/s
20120264177 - Compositions for improving the health and appearance of skin: Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health... Agent: Solazyme, Inc.
20120264178 - Methods of enabling enzymatic hydrolysis and fermentation of lignocellulosic biomass with pretreated feedstock following high solids storage in the presence of enzymes: The present invention provides methods of producing pretreated lignocellulosic biomass combined with enzymes for the storage and transporation of the pretreated lignocellulosic biomass that may be used in biofuel and bioproduct production. The methods allows the coexistence of the pretreated lignocellulosic biomass and the enzymes during storage and transporation, the... Agent:
20120264179 - Microorganisms for the production of adipic acid and other compounds: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or... Agent: Genomatica, Inc.
20120264180 - Process for the biologic treatment of organic wastes and plant therefor: Process for the biological treatment of organic wastes, includes a first anaerobic digestion phase and a second aerobic digestion phase in succession, a respective filtration phase of the solid substance being provided between the two digestion phases, a separation phase of the biogas released in the anaerobic digestion phase and... Agent: Bioenergia S.r.l.
20120264181 - Method for producing butyric acid, butanol and butyrate ester: The present disclosure is directed to methods for producing butyric acid comprising fermenting a feedstock using a bacterium. The feedstock comprises lactic acid, or the feedstock comprises lactic acid and at least one carbohydrate.... Agent: Industrial Technology Research Institute.
20120264182 - Use of a protein homologous to a meab protein for increasing the enzymatic activity of a 3-hydroxycarboxylic acid-coa mutase: The invention relates to the use of a protein homologous to a MeaB protein for increasing the enzymatic activity of a 3-hydroxycarboxylic acid-CoA mutase, a fusion protein comprising a 3-hydroxycarboxylic acid-CoA mutase and a protein sequence homologous to a MeaB protein and an enzymatic method for producing 2-hydroxyisobutryric acid.... Agent: Evonik Roehm Gmbh
20120264183 - Cellulose and xylan fermentation by novel anaerobic thermophilic clostridia isolated from self-heated biocompost: A new species of an anaerobic thermophilic cellulolytic and xylano lytic bacterium is disclosed. One particular strain of this new species has been deposited with the ATCC under Deposit No. PTA-10114. It is also provided a method for isolating, culturing and utilizing this novel bacterium for the conversion of biomass... Agent:
20120264184 - Alternative paths to alcohols and hydrocarbons from biomass: A method of producing alcohols, hydrocarbons, or both from biomass, the method including converting biomass into a carboxylic acid; reacting the carboxylic acid with an olefin to produce an ester; and hydrogenolyzing the ester to produce alcohol. The steps of reacting the carboxylic acid with an olefin to produce an... Agent: The Texas A&m University System
20120264185 - Foam microreactor for multi-phase shear-sensitive reactions: The present invention relates to a method for controlling multi-phase chemical reactions using the architecture of surfactant foams to control mass transport of chemical reactants, catalysts, and products and the kinetics with which they react. More specifically, the invention relates to transformations that require both gaseous and liquid components with... Agent:
20120264186 - Method for preparing animal cells capable of proliferation: A method for preparing animal cells with good adhesion and proliferation properties which are capable of proliferation is provided. the method permits the detachment of cultured cells without damaging the cells. A method for preparing a sheet of animal cells such as skin cells which are capable of proliferation is... Agent:
20120264187 - Reactor system for electroporation: The invention relates to a reactor system, comprising: —a reactor chamber having a length and a width, whereby the reactor chamber contains a central section along its length; —a first pulse generator to which two electrodes A1 and A2 are connected, whereby the electrodes A1 and A2 are located in... Agent:
20120264188 - Method for preparing ni-containing magnetic mesoporous silica whose surface strongly binds histidine-tagged protein, protein-binding material for degrading toxic aromatic compound comprising the magnetic mesoporous silica, and method for degrading toxic a: The present invention relates to a protein-binding material including a mesoporous silica and a method for selectively separating and purifying using the protein-binding material. More specifically, the present invention relates to a method of preparing a magnetic mesoporous silica responding to a magnetic field by adsorbing a precursor of a... Agent: Korea Institute Of Ceramic Engineering And Technology
20120264189 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent:
20120264190 - Decellularized and delipidized extracellular matrix and methods of use: Compositions comprising decellularized and delipidized extracellular matrix derived from adipose or loose connective tissue, and therapeutic uses thereof. Methods for treating, repairing or regenerating defective, diseased, or damaged adipose or loose connective tissues or organs in a subject, preferably a human, and/or for tissue engineering, filing soft tissue defects, and... Agent: The Regents Of The University Of California
20120264191 - Protein and dna sequence encoding a cold adapted-subtilisin-like activity: Nucleic acid and corresponding amino acid sequences of a cold adapted subtilisin-like activity protein, insolated from antarctic marine origin, preferably from an Antarctic bacteria (Polar ibacter sp) that can be used in a variety of industrial contexts and commercial purposes including laundry detergents, food processing, leather processing and skin care... Agent: University Of Chile
20120264192 - Adenovirus library and methods: Described herein is a method that generally includes infecting a host cell with a rescue adenovirus, wherein the rescue adenovirus genome comprises a loxP site and encodes at least one marker, and wherein the host cell comprises a library of polynucleotides that complement the adenovirus genome marker and encode a... Agent:
20120264193 - Method for producing medium and medium produced thereby: s
20120264194 - Methods of and systems for dewatering algae and recycling water therefrom: A method of dewatering algae and recycling water therefrom is presented. A method of dewatering a wet algal cell culture includes removing liquid from an algal cell culture to obtain a wet algal biomass having a lower liquid content than the algal cell culture. At least a portion of the... Agent: Heliae Development, LLC
20120264195 - High bio-productivity chlamydomonas strain dg8-108: A novel strain of the unicellular green algae Chlamydomonas reinhardtii, named “Strain DG8-108”, was created by exposing wild-type C. reinhardtii to γ-radiation exposure. This new strain demonstrates nearly double the biomass and photosynthetic productivity of wild-type C. reinhardtii under both optimal and stress conditions.... Agent:
20120264196 - Thixotropic gel for vadose zone remediation: A thixotropic gel suitable for use in subsurface bioremediation is provided along with a process of using the gel. The thixotropic gel provides a non-migrating injectable substrate that can provide below ground barrier properties. In addition, the gel components provide for a favorable environment in which certain contaminants are preferentially... Agent: Savannah River Nuclear Solutions, LLC
20120264197 - H2s removal from contaminated gases: A process for removing hydrogen sulfide from a raw natural gas stream such as biogas from landfills or controlled anaerobic digestion comprises passing the natural gas stream though a separation unit such as a PSA unit to form a product stream comprising a high concentration of methane and a low... Agent: Guild Associates, Inc.
20120264198 - In-situ reclaimable anaerobic composter: An in-situ dry anaerobic composter containing 40% to 75% by weight solids and located in a section of ground including a pit having side walls and a bottom, an essentially impervious liner located in the pit such that the liner abuts the pit side walls and bottom to form a... Agent: Waste Management, Inc.
20120264199 - Preparation method of the compounds for absorbing heavy metals: The present invention is related to a preparation method of the compounds for absorbing heavy metals. First of all, prepare natural vegetable or fruit and extract a B-M sulfur peptide from the said natural vegetable or fruit. Second, place the natural vegetable or fruit into fermentation and extract the mixed... Agent:
20120264200 - Systems and methods for isolating and using clinically safe adipose derived regenerative cells: Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating... Agent: Cytori Therapeutics, Inc.
20120264201 - Culture apparatus: A culture apparatus comprising: an inner box configured to form a culture chamber; an outer box configured to cover the inner box; a fan configured to circulate gas inside the culture chamber through an air passage provided in the inner box within the culture chamber; a first through hole configured... Agent: Sanyo Electric Co., Ltd.
20120264203 - Heat flow polymerase chain reaction systems and methods: Methods and systems for polymerase chain reactions (PCR) that are capable of detecting amplified DNA during or after the PCR process. The methods and systems may utilize DSC or DTA analysis techniques.... Agent: Heatflow Technologies, Inc.
20120264202 - System for performing polymerase chain reaction nucleic acid amplification: A printed circuit structure containing a fluidic chamber configured to receive an aqueous solution containing a sample to be analyzed and fluorophore for polymerase chain reaction analysis. The printed circuit structure also contains a heating element that provides for temperature cycling of the fluidic chamber to support polymerase chain reaction... Agent:
20120264204 - Method and apparatus using optical techniques to measure analyte levels: A device is provided for use with a tissue penetrating system and/or a metering device for measuring analyte levels. The device comprises a cartridge and a plurality of analyte detecting members mounted on the cartridge. The cartridge may have a radial disc shape. The cartridge may also be sized to... Agent:
20120264205 - Microbial decomposition treatment device and organic substance treatment unit: A organic substance treatment device is proposed which includes a cylindrical treatment tank (11) having a central raised portion on its bottom surface to create a step. An agitating vane unit (14) is provided on the raised portion. The vane unit is rotated counterclockwise if the device is located in... Agent:
20120264206 - Device for the carrying out of chemical or biological reactions: The invention relates to a device for performing biological reactions in a nucleic acid sample. The device can comprise a reaction vessel receiving element that includes a plurality of reaction vessel holders and a gastight jacket or equalization plate containing a fluid changeable between liquid and gaseous states. The gastight... Agent: Life Technologies Corporation
20120264207 - Polymeric members and methods for marking polymeric members: Generally, polymeric members and laser marking methods for producing visible marks on polymeric members, such as on thin and/or curved surfaces. The laser marking methods can include methods of laser marking straws with the step of matching laser source properties to the properties of straws being marked or with the... Agent: Inguran LLC
20120264208 - Materials and methods for enhanced iron uptake in cell culture: A serum-free, synthetic tissue culture media is described which is completely defined chemically. The media do not require any supplementation with serum to support growth of cells. The media and methods described herein can also be used for growing all types of mammalian cell lines in culture without addition of... Agent:
20120264210 - Method for expanding and/or preserving cells by means of gas enrichment of the culture medium: A method for expanding and/or preserving cells inside a culture vessel containing a culture medium provides for the renewal of the culture medium by a culture medium stream, at least a portion of which comes from a culture medium volume contained in a gas-enrichment vessel of the culture medium, the... Agent: Maco Pharma
20120264209 - Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage: Methods and devices for culturing human pluripotent stem cells to produce cells of the pancreatic lineage are disclosed. The methods include steps of culturing the stem cells under conditions that induce the expression of mesendoderm/primitive streak and definitive endoderm markers in a chemically defined medium including an effective amount of... Agent:
20120264211 - Cryopreservation of articular cartilage: The invention relates generally to methods and compositions for the cryopreservation and/or vitrification of tissue including articular cartilage and the preparation of said tissue for clinical or research use, including but not limited to joint replacement and the treatment and prevention of osteoarthritis.... Agent:
20120264212 - Compounds and methods for inhibiting the metastasis of cancer cells: The present invention relates to compounds and methods for inhibiting cancer metastasis. In an embodiment, the compound of the present invention contains the sulfatide binding region of the terminal phosphotyrosine binding domain (N-PTB) of Disabled-2 (Dab2).... Agent: Virginia Tech Intellectual Properties, Inc.
20120264213 - Device and method for delivering mechanically released cells from liposcuction aspirates: A lipoaspirate collection device to aid in the collection and processing of human tissue and fluid obtained during liposuction for use in point-of-care cell therapy. The collection device includes a collection body and a collection cap. The collection cap may have a fluid port, a lipoaspirate port, a vacuum port,... Agent: Spinesmith Partners Lp
20120264214 - Biocompatible polymerizable acrylate products and methods: Sugar-acrylic monomers are synthesized to have a carbohydrate moiety linked to an acrylate group. The sugar-acrylic monomers may be polymerized to form polymers, adhesives, hydrogels, and the like. The sugar-acrylic monomers and polymers may be used in tissue engineering, adhesives and sealers, wound healing, and the like.... Agent: Empire Technology Development LLC
20120264215 - Placenta-derived cell-conditioned culture media and animal-free, feeder-free method for culturing stem cells using the same: Disclosed are placenta-derived cell-conditioned culture media for stem cells. An animal-free, feeder-free method using the media is also provided for culturing stem cells. The media can prevent the stem cells from being contaminated with xenogeneic proteins or cells, and maintain human embryonic stem cells in an undifferentiated state for a... Agent: Korea University Research And Business Foudation Of Korea University
20120264216 - Media, kits, systems and methods for the micropropagation of bamboo: Disclosed herein are media, kits, systems and methods for achieving micropropagation of bamboo on a commercially-relevant scale.... Agent: The Red Triangle, Lcc
20120264217 - Respiratory syncytial virus expression vectors: In certain embodiments, the disclosure relates to vectors containing bacterial nucleic acid sequences and a paramyxovirus gene. Typically, the expression vector comprises a bacterial artificial chromosome (BAC), and a nucleic acid sequence comprising a respiratory syncytial virus (RSV) gene in operable combination with a regulatory element and optionally a reporter... Agent: Emory University
20120264218 - Induction of pluripotent cells: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment.... Agent: The Scripps Research Institute10/11/2012 > 103 patent applications in 59 patent subcategories.
20120258439 - Protein-free culture media products: Disclosed herein are compositions and methods for a substantially protein-free media (PFM) optimized for stem cell research.... Agent:
20120258441 - Method for controlling culture parameters in a bioreactor: s
20120258440 - Method of deciding detachment time for cell, method of subculturing cell and apparatus for subculturing cell using the same: A method of deciding detachment time of cells, and a method and apparatus for subculturing the cells using the method. The method of deciding detachment time of the cells from a culturing vessel using a separation enzyme in subculturing the cells includes: a photographing step of photographing an image of... Agent: Logos Biosystems, Inc.
20120258444 - Acoustic wave (aw) sensing devices using live cells: In one embodiment according to the invention, there is provided a method of sensing a response of a living cell or virus to a change in conditions. The method comprises applying an essentially constant external electromotive force that causes oscillation of an acoustic wave device at essentially constant amplitude and... Agent:
20120258442 - Determining tumor origin: The disclosure provides methods for the use of gene expression measurements to classify or identify among 54 cancer types in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.... Agent: Bio Theranostics, Inc.
20120258443 - Methods for the detection of jc polyoma virus: Methods and compositions for determining whether a subject is at risk for PML, including subjects being treated with immunosuppressants, by determining whether the subject harbors a JCV variant with reduced binding for sialic acid relative to a normal JCV, are presented. Furthermore, combinations of JCV-VP1 sequence variations that are associated... Agent: Biogen Idec Ma Inc.
20120258445 - Methods for using nanowire sensors: Methods for using nanowire sensors are described. In one embodiment, the nanowire sensor may be field effect transistor having a nanowire and a functionalized control electrode. One method of using such a nanowire sensor includes exposing the functionalized control electrode to a test sample and an enhancing reagent. In another... Agent: Nanolvd, Inc.
20120258448 - Mutational profile in hiv-1 gag cleavage site correlated with phenotypic drug resistance: The invention concerns novel mutations or mutational profiles of HIV-1 protease cleavage sites (CS) in the Gag region correlated with a phenotype causing alterations in sensitivity to anti-HIV drugs. The present invention also relates to the use of genotypic characterization of a target population of HIV and the subsequent association,... Agent:
20120258447 - Real-time multiplexing detection of target nucleic acid sequences with elimination of false signals: The present invention relates to the real-time multiplex detection of at least three target nucleic acid sequences with elimination of false positive signals. Unlikely to conventional real-time multiplex PCR methods, the present invention comprises two different amplification reactions in different reaction vessels from each other: a primary multiplex PCR for... Agent: Seegene, Inc
20120258446 - Universal multi-variant detection system: The present invention provides a method to diagnostically detect the variants of a given pathogen, such as HIV, hepatitis C, hepatitis B (HBV), Parvovirus B19, etc., with the use of a single detection probe.... Agent: New York Blood Center, Inc.
20120258452 - Dna-based molecular switches and uses thereof: Disclosed are nucleic acid-based molecular switches that respond to changes in pH. The switches may be used in DNA nanodevices. The switches may also act as sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The switch includes an A-motif that forms at acidic... Agent:
20120258451 - Laser isolation of viable cells: Methods for laser microdissection isolation of viable cells are provided. Cells of a desired type may be isolated from a diverse population, optionally with detection and exclusion of undesired cells. Desired cells may be isolated from a population that arose from differentiation of pluripotent cells, preferably embryonic stem cells or... Agent: Advanced Cell Technology, Inc.
20120258450 - Method for monitoring gene expression of translation and integral/secretory protein synthesis by magnetic resonance spectroscopy (mrs): Disclosed is a method for monitoring change in gene expression of translation and integral/secretory protein synthesis in a sample comprising measuring the amount of Choline and/or a fatty acid present in the sample as a function of time wherein the measurement is carried out by Magnetic Resonance Spectroscopy (MRS) and... Agent: Receptomon, LLC
20120258449 - Method of determining the nucleotide sequence of oligonucleotides and dna molecules: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown... Agent: Arizona Board Of Regents
20120258454 - Bisulfite conversion of dna: The present invention relates to an improved method for the bisulfite conversion of DNA. In certain time-temperature ranges the efficacy of the bisulfite conversion is clearly improved. By combination with denaturating solvents, new reaction conditions and new purification methods the efficacy can be further increased The converted DNA can subsequently... Agent: Epigenomics Ag
20120258458 - Interferon-like protein zcyto21: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.... Agent: Zymogenetics, Inc.
20120258457 - Methods for detection of a single- or double-stranded nucleic acid molecule: The present invention is related to a method for the detection of a nucleic acid molecule comprising at least a strand comprising a sequence of nucleotides in a sample, whereby the method comprises the following steps: providing a sample containing the nucleic acid molecule; providing a capture probe, whereby the... Agent: Noxxon Pharma Ag
20120258456 - Monitoring recombinase polymerase amplification mixtures: A process includes providing a mixture that includes a recombinase, a single-strand binding protein, and one or more oligonucleotides; and detecting particles in the reaction mixture.... Agent: Alere San Diego, Inc.
20120258453 - Nucleic acid probe-based diagnostic assays targeting ssra genes of prokaryotic and eukaryotic organisms: Use of the ssrA gene or tmRNA, an RNA transcript of the ssrA gene, or fragments thereof as target regions in a nucleic acid probe assay for the detection and identification of prokaryotic and/or eukaryotic organisms is described. Nucleotide sequence alignment of tmRNA sequences from various organisms can be used... Agent:
20120258455 - Rnase h-based assays utilizing modified rna monomers: The present invention provides methods of cleaving a nucleic acid strand to initiate, assist, monitor or perform biological assays.... Agent: Integrated Dna Technologies, Inc.
20120258459 - System and method for particle filtration: Embodiments of the present disclosure feature a filtration system comprising a filtration module for particle filtration and methods of using the device for the isolation of particles (e.g., viable cells). Advantageously, embodiments of the device provide for the high throughput filtration of large volumes of sample while preserving cell viability... Agent: Cytovera Inc.
20120258462 - Combinations of tumor-associated antigens in diagnostics for various types of cancers: Disclosed herein are methods for matching a cancer condition with an appropriate immunotherapeutic agent and/or regimen. Also disclosed are methods for confirming diagnosis of a particular type of cancer. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs to optimize the match between... Agent: Mannkind Corporation
20120258464 - Method for detection and quantification of wheat endogenous gene: Provided is a method of detecting or quantifying a wheat species-specific DNA in a test sample by polymerase chain reaction. The method comprises a step of amplifying a nucleic acid molecule having a partial sequence of a nucleotide sequence identified as SEQ ID NO: 1 using a nucleic acid molecule... Agent:
20120258461 - Methods for determining and inhibiting rheumatoid arthritis associated with the braf oncogene in a subject: The invention provides methods for determining whether a subject is suffering from a rheumatoid arthritis associated with the BRAF oncogene comprising contacting isolated fibroblasts from the subject with a molecule or pool of molecules directed to the BRAF oncogene; and culturing the sample in the presence of the agent and... Agent:
20120258463 - Rack for sample tubes and reagent holders: A rack for holding samples and various reagents, wherein the rack may be used for loading the samples and reagents prior to using the reagents. The rack accepts complementary reagent holders, each of which contain a set of reagents for carrying out a predetermined processing operation, such as preparing biological... Agent: Handylab, Inc.
20120258460 - Sso7-polymerase conjugates with decreased non-specific activity: Improved Sso7-polymerase conjugate proteins are provided... Agent: Bio-rad Laboratories, Inc.
20120258465 - Mutant apoprotein of photoprotein with low calcium sensitivity: Calcium-binding photoproteins showing the luminescence pattern with a slow decay of are desired. The invention provides a mutant apoprotein comprising an amino acid sequence wherein the 23rd to 34th amino acids in the amino acid sequence of SEQ ID NO: 2 are substituted with an amino acid represented by formula... Agent: Jnc Corporation
20120258466 - Filtration device for assays: A device and method for filtering blood is disclosed herein. The device can filter blood and attach analytes within the blood to magnetic particles. The analytes can then be strongly bound to an analyzing device by a magnetic force. The analytes can then be counted by the analyzing device and... Agent: Silicon Biodevices, Inc.
20120258467 - Transdermal systems, devices, and methods to optically analyze an analyte: The invention provides transdermal optical analysis systems, test sensors, methods, and kits for determining the presence and/or concentration of at least one analyte in a fluid sample. The system includes a transdermal test sensor including an aqueous material including at least one analyte selective reagent and at least one optically... Agent: Bayer Healthcare LLC
20120258474 - Methods of detecting dna damage: The present invention relates to methods of detecting agents that cause or may potentiate DNA damage, and to assays that may be employed in such methods. In particular, the invention relates to methods of detecting DNA damage in in vitro cultures of human cells.... Agent: Ge Healthcare Uk Limited
20120258475 - Recovery of rare cells using a microchannel apparatus with patterned posts: A microflow apparatus for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts. The posts are spaced across the width of a collection region in the flow path, extending between the upper... Agent: Biocept, Inc.
20120258476 - Methods for inducing a natural killer (nk) cell-mediated immune response and for increasing nk cell activity: This disclosure relates to methods of inducing a natural killer (NK) cell-mediated immune response and increasing NK activity in a mammal for the treatment of tumors and virus infections, comprising isolating peripheral blood mononuclear cells (PBMCs) from a subject, exposing them in vitro to a protein conjugate comprising granulocyte macrophage... Agent: Dendreon Corporation
20120258468 - Indicator agent for noninflammatory stress response and use thereof: A system enabling the molecular biological visualization and quantitative detection of events in a stress-exposed living organism and a means enabling the management of stress are provided. An indicator agent for non-inflammatory stress responses mediated by superoxide, which comprises IL-18, a visualizing agent for non-inflammatory stress responses for detecting the... Agent:
20120258469 - Methods and devices for using mucolytic agents including n-acetyl cysteine (nac): Devices and methods incorporate mucolytic agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters one or more lysis agents and/or mucolytic agents. The mucolytic agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the mucolytic agent is localized... Agent: Rapid Pathogen Screening, Inc.
20120258470 - Compositions comprising a dehalogenase substrate and a radionuclide and methods of use: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one... Agent: Promega Corporation
20120258471 - Peptide marker for cancer diagnosis, and cancer diagnosis method using same: The present invention relates to a peptide marker for cancer diagnosis and a cancer diagnosis method using the same, more precisely to a peptide marker for cancer diagnosis screened by the following steps: separating and concentrating glycoproteins including a certain glycan chain related to the occurrence of cancer; hydrolyzing the... Agent: Korea Basic Science Institute
20120258473 - Method of collecting specimen and method of diagnosing subject to detect upper digestive system disease: A method of collecting a specimen of the present invention is used in detecting upper digestive system disease. The method of collecting a specimen includes: a step of positioning sampling equipment in the duodenum of the subject into which duodenal juice is secreted, the sampling equipment being used to collect... Agent: Olympus Corporation
20120258472 - Systems and methods of fluidic sample processing: The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.... Agent:
20120258479 - Assay device having rhombus-shaped projections: An assay device includes: a liquid sample receiving zone; a capture zone in fluid communication with the sample receiving zone having capture elements bound thereto, the capture zone having a substrate and projections which extend substantially vertically from the substrate, the projections having a rhombus-shaped cross-section and the projections arranged... Agent:
20120258477 - Fecal neopterin concentration measurement as an indicator of disease activity in inflammatory bowel disease: Disclosed are methods for determining disease activity in a patient having or at risk for developing inflammatory bowel disease (IBD) which include measuring neopterin concentration in a fecal sample from the patient.... Agent: Northwestern University
20120258478 - Method of collecting specimen and method of diagnosing subject to detect upper digestive system disease: A method of collecting a specimen of the present invention detects upper digestive system disease. The method of collecting a specimen includes: a step of administering a stimulant of pancreatic juice secretion or a stimulant of bile secretion to a subject; a step of positioning sampling equipment in the duodenum... Agent: Olympus Corporation
20120258480 - Adp detection based luminescent phosphotransferase or atp hydrolase assay: The invention provides provides compositions and methods to determine or detect the activity of enzymes, including phosphotransferases such as kinases (e.g., protein, lipid, and sugar kinases) and ATP hydrolases such as ATPases, e.g., HSP90, that employ ATP as a substrate and form ADP as a product by monitoring changes in... Agent: Promega Corporation
20120258481 - Cross-linking atp analogs: An adenosine 5′-triphosphate analogs modified at the gamma-phosphate with a reactive reagent. A method of forming the analog by activating a 4-amino benzoic acid, incubating the activated acid to obtain an amine, and coupling the amine with ATP in the presence of water soluble EDCI. A method of detecting the... Agent: Wayne State University
20120258482 - Pcna methyltransferase: Proliferating cell nuclear antigen (PCNA)-dependent glutamate methyltransferases are disclosed that can methylesterify one or more glutamic acid or aspartic acid residues of PCNA.... Agent: Indiana University Research And Technology Corporation
20120258484 - Cancer diagnosis marker using the aberrant glycosylation of a protein: The present invention relates to a method for diagnosing cancer using information on the aberrant glycosylation of a glycoprotein. More precisely, the present invention relates to a cancer diagnosis peptide marker, which is screened by: a step of separating, using a lectin, a glycoprotein which is aberrantly glycosylated in accordance... Agent: Korea Basic Science Institute
20120258483 - Method for detecting a wound infection: The present invention relates to a method for detecting a wound infection comprising the steps of: contacting a sample obtained from a wound with at least two substrates for at least two enzymes selected from the group consisting of lysozyme, elastase, cathepsin G and myeloperoxidase, and detecting a wound infection... Agent: Forschungsholding Tu Graz Gmbh
20120258485 - Method for detecting and quantifying a target molecule in a sample: e
20120258486 - Calcium-binding photoprotein, gene encoding the same, and use thereof: A protein according to the invention can be used to detect or measure calcium ions is provided. Further the protein is useful as a reporter protein or a luminescence marker. A polynucleotide according to the invention is also useful as a reporter gene.... Agent: Jnc Corporation
20120258487 - Microfluidic platform for synthetic biology applications: This invention provides methods and compositions for assembling biological constructs (e.g., plasmids, transformed cells, etc.). In certain embodiments the methods involve encapsulating separate components of said biological construct each in a fluid droplet confined in a fluid channel; optionally mixing droplets from different fluid channels to for a sequenced order... Agent: Sandia Corporation
20120258488 - Systems and methods for electrophysiological activated cell sorting and cytometry: Provided herein are methods and systems for non-genetic, label-free cell purification (i.e., cell cytometry and sorting), which classifies cells based on their spontaneous electrophysiological response or their electrophysiological response to a stimulus. For example, in one embodiment, there is provided a method of cell sorting comprising: stimulating a cell with... Agent: The Board Of Trustees Of The Leland Stanford Junior University
20120258489 - Fungal promoters for expressing a gene in a fungal cell: The present invention relates to isolated fungal promoter DNA sequences, to DNA constructs, vectors, and fungal host cells comprising these promoters in operative association with coding sequences encoding polypeptides. The present invention also relates to methods for expressing a gene and/or producing a polypeptide using the new promoters isolated. The... Agent: DsmIPAssets B.v.
20120258490 - Process for producing dipeptides or dipeptide derivatives: The present invention provides a process for producing a dipeptide or a dipeptide derivative using a phosphate donor, a substance selected from the group consisting of adenosine-5′-monophosphate, adenosine-5′-diphosphate and adenosine-5′-triphosphate, one or more kinds of amino acids or amino acid derivatives, and as enzyme sources, a protein having polyphosphate kinase... Agent: Kyowa Hakko Bio Co., Ltd.
20120258492 - Bacterial host strain: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene... Agent: Ucb Pharma S.a.
20120258491 - Expression of biologically active polypeptides in duckweed: Methods, nucleic acid sequences, and transformed duckweed plant or duckweed nodule cultures for the expression and the secretion of biologically active polypeptides from genetically engineered duckweed are provided. Expression of recombinant polypeptides in duckweed is improved by modifying the nucleotide sequence of the expression cassette encoding the polypeptide for improved... Agent: Biolex Therapeutics, Inc.
20120258493 - Promoter sequences: The present invention relates to new promoter sequences and uses thereof, in particular expression cassettes, vectors, and methods of expressing genes using the new promoters.... Agent: Sandoz Ag
20120258494 - Retroviral vector particles and methods for their generation and use: The present invention relates to methods of host cell transduction utilising ecotropic retroviral vector particles. The retroviral vector particle may comprise an envelope of Friend murine leukaemia virus, in particular the envelope encoded by molecular clone PVC-211 and the host cell may be engineered to recombinantly express the Reel receptor.... Agent: 4-anitbody Ag
20120258497 - Alpha-amylases: The present invention relates to alpha-amylase variants, polynucleotides encoding the variants and nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes.... Agent: Novozymes A/s
20120258496 - Production of low fucose antibodies in h4-ii-e rat cells: The invention concerns the field of cell culture technology. It specifically concerns a rat hepatoma cell, preferably a H4-II-E rat hepatoma cell, carrying a DNA encoding an antibody or Fc-fusion protein and having low fucosylation activity for adding fucose to glycosidic structures such as biantennary glycans, e.g. N-acetylglucosamine. The invention... Agent: Boehringer Ingelheim International Gmbh
20120258495 - Sequence diversity generation in immunoglobulins: Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations... Agent:
20120258498 - High yield antibiotics producing fungus strain, preparation method and use thereof: High yield antibiotics producing fungus strain, preparation method and use thereof are provided. The fungus strain is a mutant derived from Glarea lozoyensis, and deposited in CGMCC with the accession number of CGMCC 2933. The preparation method concludes following steps: (a) mixing the culture media of Glarea lozoyensis strain ATCC... Agent: Shanghai Techwell Biopharmaceutical Co., Ltd.
20120258501 - Dna polymerases with improved activity: Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host... Agent: Roche Molecular Systems, Inc.
20120258500 - Pcr reaction mixtures with decreased non-specific activity: The present invention provides methods for improving the specificity of nucleic acid amplification comprising incubating a nucleic acid molecule with a polymerase-Sso7 DNA binding domain conjugate and arginine, spermidine, or spermine. The present invention also provides reaction mixtures and kits for improving the specificity of nucleic acid amplification.... Agent: Bio-rad Laboratories, Inc.
20120258499 - Recombinase polymerase amplification: The present invention features novel, diverse, hybrid and engineered recombinase enzymes, and the utility of such proteins with associated recombination factors for carrying out DNA amplification assays. The present invention also features different recombinase ‘systems’ having distinct biochemical activities in DNA amplification assays, and differing requirements for loading factors, single-stranded... Agent: Alere San Diego, Inc.
20120258502 - Method of producing recombinant plasmid dna using substantially solid growth medium: A method of producing recombinant plasmid DNA using substantially solid growth medium and disposable vessels in place of conventional liquid fermentation processes. The method includes inoculating a host organism containing the recombinant plasmid DNA onto the substantially solid growth medium in a disposable vessel; allowing the host organism to grow... Agent:
20120258503 - Consolidated pretreatment and hydrolysis of plant biomass expressing cell wall degrading enzymes: Methods for consolidated pretreatment and hydrolysis of genetically engineered plants expressing cell wall degrading enzymes are provided. Expression cassettes and vectors for making transgenic plants are described. Plants engineered to express one or more cell wall degrading enzymes using expression cassettes and vectors of the invention are also provided.... Agent: Agrivida, Inc.
20120258504 - Biological synthesis of difunctional alkanes from carbohydrate feedstocks: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production... Agent: Celexion, LLC
20120258505 - Hydrolases, nucleic acids encoding them and methods for making and using them: Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils,... Agent: Bunge Oils, Inc.
20120258506 - Cell-based systems for production of methyl formate: Disclosed is a process in which a recombinant organism, such as a yeast, expressing a heterologous S-adenosylmethionme (SAM)-dependent methyl halide transferase (MHT) protein is combined with a halide and a carbon source in a cultivation medium under conditions in which methyl formate is produced. The cell may genetically modified to... Agent: The Regents Of The University Of California
20120258507 - Detergent compositions containing thermobifida fusca lipase and methods of use thereof: The present compositions and methods relate to a lipase cloned from Thermobifida fusca, polynucleotides encoding the lipase, and methods of use thereof. The compositions and methods have particular application in detergent cleaning compositions and methods.... Agent: Danisco US Inc.
20120258508 - Alternative paths to alcohols and hydrocarbons from biomass: A method of producing hydrocarbons from biomass that includes converting at least a portion of the biomass into a first product having at least one of a carboxylic acid, a ketone, an ammonium carboxylate salt, and combinations thereof; converting at least a portion of the first product into an alcohol;... Agent: The Texas A&m University System
20120258509 - Methods and systems for pretreatment and processing of biomass: A method of biomass pretreatment that includes forming a mixture comprising alkali and lignocellulosic biomass; controlling at least one physical property of the mixture selected from the group of pressure, temperature, and a combination thereof; contacting the mixture with a fluid; fermenting at least a portion of the mixture; and... Agent: The Texas A&m University System
20120258510 - Vinyl acid monomer recovery: The present disclosure relates to a method for recovering a vinyl acid monomer by providing an aqueous fermentation broth which undergoes microbial fermentation of a nutrient medium containing a carbon source including at least one microorganism to produce a vinyl acid monomer. The method provides a direct overall route to... Agent: University Of New Hampshire
20120258511 - Genes related to xylose fermentation and methods of using same for enhanced biofuel production: The present invention provides isolated gene sequences involved in xylose fermentation and related recombinant yeast which are useful in methods of enhanced biofuel production, particularly ethanol production. Methods of bioengineering recombinant yeast useful for biofuel production are also provided.... Agent: Wisconsin Alumni Research Foundation
20120258512 - Static solid state bioreactor and method for using same: A static solid state bioreactor and method of using same. The bioreactor comprises a vessel having an upper end and a lower end, the upper end having a sealable opening. A gas distribution system in communication with the upper end and the lower end of the vessel. A liquid distribution... Agent:
20120258513 - Selective neuronal nitric oxide synthase inhibitors: Compounds and related methods for selective inhibition of neuronal nitric oxide synthase over inducible and endothelial isoforms, such compounds as can provide reduced cationic character and enhanced bioavailability.... Agent: Northwestern University
20120258515 - Cytolytic rtx-toxin from gallibacterium anatis: The present invention relates to the field of animal health and in particular the causative agent of a new bacterial poultry disease caused by Gallibacteruim spp, including Gallibacterium anatis, Gallibacterium genomospecies 1 and Gallibacterium genomospecies 2. The invention provides a novel RTX toxin from said Gallibacterium species, the novel toxin... Agent: KØ Benhavns Universitet
20120258514 - Kits for analysis of biological samples: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.... Agent: Anaspec Incorporated
20120258516 - System and methods for making and processing emulsions: An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may... Agent: Life Technologies Corporation
20120258517 - Cytolethal distending toxins and detection of campylobacter bacteria using the same as a target: The present inventors succeeded in cloning the CDT genes of C. coli and C. fetus, which were previously unknown, and in determining their sequences. In addition, the inventors also developed specific primers and primers common to the two species by comparing the CDTs of C. jejuni and C. fetus. Furthermore,... Agent: Fuso Pharmaceutical Industries, Ltd.
20120258518 - Method for incorporating internal polar and ionizable groups in proteins: Internal polar and ionizable groups are essential for enzymatic catalysis, proton transport, redox reactions, and many other functional properties of proteins. To engineer novel enzymes or to modify the function of existing ones, and to build switches that can be used to modify the stability of proteins in response to... Agent: The Johns Hopkins University
20120258519 - Protein harvesting: Methods of harvesting proteins directly from bioreactors to avoid at several steps in the purification of recombinant drugs are disclosed.... Agent: Therapeutic Proteins Inc.
20120258520 - Polypeptides having beta-glucosidase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes. Inc.
20120258521 - Methods and genetically engineered micro-organisms for the combined production of pdo, bdo and php by fermentation: The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by fermentation. In particular, the invention relates to a genetically engineered micro-organism suitable for combined production of PDO, BDO and PHP by fermentation, characterized in that: compared with corresponding... Agent: Tsinghua University
20120258522 - Method for treating waste: A method of treating waste comprises first separating the waste material into at least one first fraction, preferably with waste parts above a predetermined size of waste parts, and into a second organic-rich fraction, preferably with waste parts below the specified size of waste parts. Next the second fraction is... Agent: Kompoferm Gmbh
20120258523 - Process for remediating biofouling in water systems with virulent bacteriophage: Bacterial contamination of industrial water systems lead to biofouling by biofilms and corrosion from bacterial induced corrosion. This invention provides a method for control of fouling and contamination of industrial water systems caused by bacteria. Prevention or reduction of process interruptions and general contamination, fouling and corrosion is achieved by... Agent: Phage Biocontrol Research, LLC
20120258524 - Annealing curve analysis in pcr: The present invention is directed to devices for performing PCR and monitoring the reaction of a sample comprising a nucleic acid and a fluorescent dye. Illustrative devices comprise a heat exchange component for heating and cooling the sample, a control device for repeatedly operating the heat exchange component to subject... Agent:
20120258525 - Device for bacteria classification and pretreatment device for bacteria test: When automatically classified results are different from judgment of a laboratory technician, the laboratory technician has to reselect the bacterial colonies one-by-one to be a pickup colony through watching the displayed image. To get rid of the inconvenience, provided is a pretreatment device for a bacteria test comprising: a specification... Agent:
20120258526 - Packing material comprising starch-modified polyurethane for the biofiltration of organic compounds present in gaseous or liquid effluents, production methods thereof and biofiltration system: The invention relates to a packing material for biofilters, having a polyurethane polymer and starch. The packing material is resistant to compaction, can sorb pollutant organic compounds and reduces the start-up time of the biofilter. The packing material can be used as a substrate in the biofiltration of volatile and/or... Agent:
20120258527 - Bioreactor: A bioreactor including a substantially horizontal containing vessel having a base and at least one upstanding side-wall, at least one inlet located at a lower portion of the containing vessel, at least one outlet located at an upper portion of the containing vessel, an upper wall having a reflective material... Agent:
20120258528 - Culture apparatus: A culture apparatus comprising: a fan configured to circulate air inside a culture chamber in a predetermined direction in the culture chamber; a duct configured to guide air circulating inside the culture chamber along a wall face inside the culture chamber from an upper part to a lower part of... Agent: Sanyo Electric Co., Ltd.
20120258529 - Apparatus for separating target molecules and method of separating target molecules by using the same: An apparatus for separating target molecules includes a plurality of protruding portions on a first sidewall of a fluid channel to control a flow of a fluid containing the target molecules, and a fluid channel portion having a variable height for separating the target molecules depending on sizes of the... Agent: Samsung Electronics Co., Ltd.
20120258532 - Drug resistant immunotherapy for treatment of a cancer: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immune cell line and uses thereof in conjunction with cytotoxic drugs.... Agent:
20120258530 - Novel therapeutical tools and methods for treating blindness: The present inventions relates to the use of an isolated nucleic acid molecule comprising a nucleotide sequence coding for a hyperpolarizing light-gated ion channel or pump gene from an archeon or for a light-active fragment of said gene, or the nucleotide sequence complementary to said nucleotide sequence, for treating or... Agent: Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Resear
20120258531 - Systems and methods for harvesting target particles of a suspension: Tube and float systems and methods for isolating, enumerating, and harvesting target materials of a suspension are described. In one aspect, a tube and float system includes a filter embedded in a tube cap. The filter enables the passage of fluids but prevents the passage of the target materials. The... Agent:
20120258533 - Protein-free culture media products for manufacturing viral-based vaccines: Disclosed herein are compositions and methods for a substantially protein-free media (PFM) optimized for cultivation of mammalian and/or avian cell-lines for manufacturing viral-based vaccines.... Agent: Cellcura Asa
20120258534 - Method of delivering rna interference and uses thereof: The invention provides a method of RNA interference, which comprises contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a fusion protein, the fusion protein comprising (1) a targeting moiety, which will specifically... Agent: Immune Disease Institute, Inc.
20120258535 - Methods and compositions for the specific inhibition of gene expression by double-stranded rna: The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded... Agent: City Of Hope
20120258536 - Method and device for dispersion of assemblies of biological material: Methods and devices for dispersion of assemblies of biological material (such as plant embryogenic mass, plant tissue, cultured plant cells, animal tissue and/or cultured animal cells) suspended in a liquid are disclosed. The methods comprise i) subjecting the assemblies of biological material to fluid dynamics forces causing axially extensional strain... Agent: Georgia Tech Research Corporation
20120258537 - I-crei meganuclease variants with modified specificity, method of preparation and uses thereof: Method of preparing I-CreI meganuclease variants having a modified cleavage specificity, variants obtainable by said method and their applications either for cleaving new DNA target or for genetic engineering and genome engineering for non-therapeutic purposes. Nucleic acids encoding said variants, expression cassettes comprising said nucleic acids, vectors comprising said expression... Agent: Cellectis
20120258538 - Culture method for hematopoietic stem cells: By culturing hematopoietic stem cells in the presence of SFRP-F protein, hematopoietic stem cells for hematopoietic stem cell transplantation can be produced.... Agent: Keio University
20120258539 - Use of nibp polypeptides: Methods for regulating NF-κB activation in cells comprising introducing into the cell a vector comprising a nucleic acid sequence encoding a NIK and IKK2 Binding Protein (NIBP) polypeptide, wherein the NIBP polypeptide is expressed in the cell, are provided. Also provided are methods for reversing the cancerous phenotype of a... Agent: Temple University Of The Commonwealth Of Higher Education Office Of Technology Transfer
20120258540 - Methods for modifying virus surfaces: Nucleic acid delivery vehicles and methods of their use are provided. One embodiment provides a virus having a lipid-polymer conjugate intercalated into the virus's membrane. The lipid-polymer conjugate includes a biocompatible polymer having first and second ends, a lipid conjugated to the first end, and a targeting moiety conjugated to... Agent: Georgia Tech Research Corporation
20120258541 - Chromosomal landing pads and related uses: Provided herein are methods for stable integration and/or expression of one or more recombinant polynucleotides in a host cell. The recombinant polynucleotides are typically integrated into the host genome at some native chromosomal integration sites. The integration can be mediated by homologous recombination or by using a hybrid recombinase targeting... Agent: The Scripps Research Institute10/04/2012 > 127 patent applications in 75 patent subcategories.
20120251998 - Device and method for blood treatment with single needle operation: The present invention relates to a device and a method for blood treatment in a single-needle operating mode. The blood treatment device has an extracorporeal blood circuit comprising a blood supply line leading to the inlet of a blood treatment unit and a blood return line leading away from the... Agent:
20120252001 - Method of blood pooling and storage: The disclosure provides methods of making a red blood cell, plasma, and platelet products having a uniform dose and volume. The method comprises pooling a plurality of blood units, leukoreducing the blood and inactivating any pathogen contained therein. Plasma, RBCs, and platelets are then divided into uniform dose and volume... Agent: New York Blood Center, Inc.
20120252000 - Real time multipoint assay for optimizing performance: Described herein are methods of optimizing the performance of a mammalian semen sample with respect to outcomes such as fertility, using a multipoint assay to determine an optimum time point for preparing the semen sample for use in insemination. The multipoint assay is based upon a kinetic model of biomarker... Agent:
20120251999 - Vitrification systems and methods: The embodiments of the invention described herein relate to systems and methods for the vitrification of biological samples. Vitrification is achieved by generating nanodroplets of a solution comprising the biological sample with a means that can be automated and adapted to high-throughput applications.... Agent: The Brigham And Women's Hospital, Inc.
20120252003 - Bacteria identification by phage induced impedance fluctuation analysis: Methods for detection and identification of bacteria within a sample include the step of inserting a pair of electrodes into the sample. A first impedance across the electrodes is established with a first AC voltage source having a first frequency. A phage is introduced into the sample, and impedance fluctuations... Agent: United State Of America, As Represented By The Secretary Of The Navy
20120252002 - Fluorescent nanoparticle composites themselves, process for the preparation of such composites, and use in rapid diagnosis systems with affinity to biological molecules: The present invention provides fluorescent nanoparticle composites themselves, the process of preparing such composites, to systems for rapid diagnosis (as “kits”) containing such composites, and to the use of such composites. In a preferential embodiment, the composites of the present invention have an affinity for biological molecules, such as DNA.... Agent: Universidade Federal De Pernambuco- Ufpe
20120252004 - Highly sensitive immunochromatography method: Provided is an immunochromatography method that enables highly sensitive detection by reducing the background density of a non-measurement site in the immunochromatography method. The immunochromatography method includes developing a complex of a substance to be tested and a labeling substance containing a metal modified with a first binding substance for... Agent: Fujifilm Corporation
20120252006 - Methods and systems for multiple control validation: The invention provides methods for validating a multiplex binding assay that results in a reduced number of false invalidations. The invention further provides systems for validating a multiplex binding assay that results in a reduced number of false invalidations. The invention further provides a computer readable medium containing program instructions... Agent: Laboratory Corporation Of America Holdings
20120252005 - Multi-wavelength analyses of sol-particle specific binding assays: The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms... Agent: Abaxis, Inc.
20120252007 - Optimized real time nucleic acid detection processes: This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the... Agent: Enzo Biochem, Inc.
20120252011 - Composition for treatment of pancreatic cancer: Disclosed is a composition for treating pancreatic cancer. The composition comprises a pharmaceutically effective amount of an antisense nucleic acid or siRNA that inhibits expression of at least one gene selected from the group consisting of SON gene, MCM5 gene, WDR5 gene, PBK gene and CENPA gene. The composition inhibits... Agent: Tokyo Women's Medical University
20120252008 - Compositions and methods for capture and elution of biological materials via particulates: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a... Agent: Claremont Biosolutions, LLC
20120252010 - Labelled nucleotides: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.... Agent: Illumina Cambridge Limited
20120252009 - Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides: Compositions and methods are provided for enriching non-target polynucleotides from a mixture of non-target and target polynucleotides where differences between the target polynucleotides and the non-target polynucleotides include the extent of modified bases that are present in a greater density in the target polynucleotides than in the non-target polynucleotides. This... Agent: New England Biolabs, Inc.
20120252019 - Detection of bladder cancers: The present invention generally relates to methods of screening for cancer. Methods of the invention involve identifying a threshold parameter of a protein and of two or more nucleic acids, where the threshold parameters are indicative of the absence of cancer, conducting an assay in a sample to determine a... Agent: Predictive Biosciences, Inc.
20120252017 - Device and method for extraction and analysis of nucleic acids from biological samples: Device and methods for extracting and analyzing nucleic acids from biological samples.... Agent: Blood Cell Storage, Inc.
20120252021 - Dopaminergic neuron progenitor cell marker 187a5: An object of the present invention is to provide a probe, a primer, a primer set and an antibody for use in the detection or selection of a dopaminergic neuron progenitor cell. The present invention provides a probe, a primer and a primer set for use in the detection or... Agent: Eisai R&d Managmenet Co., Ltd.
20120252023 - Materials and methods useful for affecting tumor cell growth, migration and invasion: It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance... Agent: The Ohio State University
20120252012 - Method for detecting prokaryotic dna from a feces sample:
20120252018 - Method of detecting an analyte in a sample using semiconductor nanocrystals as a detectable label: The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength.... Agent: Life Technologies Corporation
20120252014 - Method of normalized quantification of nucleic acids using anchor oligonucleotides and adapter oligonucleotides: The present invention is related to normalized quantification of nucleic acids and to the normalization of quantities of nucleic acids in samples, e.g. mixtures of nucleic acids. The present invention relates to method for the normalization of the quantity of a nucleic acid to be quantified in a sample to... Agent:
20120252015 - Methods and compositions for detecting genetic material: The present disclosure provides methods and compositions for detecting polynucleotides in a sample and for quantifying polynucleotide load in a sample. The polynucleotides can be associated with a disease, disorder, or condition. In some applications, methylated DNA is quantified, e.g., in order to determine the load of polynucleotides in a... Agent: Bio-rad Laboratories
20120252022 - Methods and compositions for the diagnosis and treatment of thyroid cancer: Methods for detecting, diagnosing and monitoring thyroid cancer in a subject are described comprising measuring in a sample from the subject markers including Ep-ICD and β-catenin. The invention also provides kits and compositions for carrying out the methods of the invention.... Agent:
20120252013 - Methods for identifying multiple dna alteration markers in a large background of wild-type dna: Methods for simultaneously surveying the status of a large number of DNA mutation markers are described. In addition, methods for simultaneously determining the methylation status at multiple sites of a collection of genes, in a single assay, are described.... Agent: Cleveland State University
20120252016 - Optimized oligonucleotides and methods of using same for the detection, isolation, amplification, quantitation, monitoring, screening, and sequencing of group b streptococcus: Described herein are oligonucleotides useful for detecting, isolating, amplifying, quantitating, monitoring, screening and sequencing GBS genes and methods of using the described oligonucleotides.... Agent: Intelligent Medical Devices, Inc.
20120252024 - Probe for detection of polymorphism in c-kit gene and use thereof: The present invention provides probes that can identify different polymorphisms in a c-kit gene easily with high reliability and use thereof.... Agent: Arkray, Inc.
20120252020 - Screening assay for bladder cancer: The present invention generally relates to methods of screening for cancer. Methods of the invention involve identifying a threshold parameter of a protein and of two or more nucleic acids, where the threshold parameters are indicative of the absence of cancer, conducting an assay in a sample to determine a... Agent: Predictive Biosciences, Inc.
20120252026 - Cancer biomarker, diagnostic methods, and assay reagents: This disclosure describes APOBEC3B as a biomarker for certain cancers such as, for example, breast cancer. This disclosure therefore describes methods for detecting APOBEC3B in a biological sample. The methods generally include measuring expression of APOBEC3B in a biological sample obtained from a patient and identifying the patient as having... Agent:
20120252027 - Method for rapidly evaluating performance of short interfering rna with novel chemical modifications: It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It... Agent:
20120252025 - Methods for covalent linking of optical reporters: A method to link a light emitting reporter to biomolecules with nucleotide oligomers is described. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particle generated by the methods of... Agent: Apdn, Inc.
20120252028 - Target genes for cancer therapy: The invention provides new gene targets for cancer chemotherapy, their use in assays for identifying new small molecule cancer chemotherapeutic agents, methods for inhibiting cancer cell growth comprising contacting a cell with a gene expression blocking agent that inhibits the expression of such genes and methods for therapeutic treatment of... Agent:
20120252029 - Simultaneous quantitative multiple primer detection of clostridium difficile: This invention comprises a multiplex-capable oligonucleotide which is capable of hybridizing to at least one of the C. difficile tcdB, tcdC, or cdtB genes, wherein, wherein said primer consists of a sequence selected from the group consisting of SEQ ID NOS: 1 through 9, or a sequence that exhibits no... Agent: Brown University
20120252030 - 5-bromo-2'-deoxy-uridine labeled nucleotide triphosphates and nucleic acid probes and methods of making and using the same: 5-bromo-2′-deoxy-uridine (BrdU) labeled nucleotide triphosphates and nucleic acid probes are described herein. The BrdU labeled nucleotide triphosphates include a linker between the nucleotide triphosphate and the BrdU moiety. The linker can be cleavable or non-cleavable. The nucleotide triphosphates can be a ribonucleotide triphosphates, 2′-deoxyribonucleotide triphosphates or 2′,3′-dideoxyribonucleotide triphosphates. The nucleic... Agent: Life Technologies Corporation
20120252031 - Compositions and methods for regulating sas1r: The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor. Six SAS1R variants, including the full length SAS1R, were identified. mSLLP1 and... Agent: University Of Virginia Patent Foundation
20120252035 - Gdf-15 and/or troponin t for predicting kidney failure in heart surgery patients: The present disclosure relates to the field of laboratory diagnostics. Specifically, means and methods are disclosed for determining a patient's risk of suffering from acute kidney injury after a surgical procedure based on the detection of GDF-15, troponin T and/or a natriuretic peptide.... Agent: Roche Diagnostics Operations, Inc.
20120252032 - Immunoassay device with improved sample closure: An apparatus and method for sealing a fluid sample collection device, comprising loading a fluid sample collection device with a fluid sample, said device comprising a housing having at least one substantially planar surface that includes an orifice in fluid communication with an internal fluid sample holding chamber which terminates... Agent: Abbott Point Of Care Inc.
20120252034 - Quality assays for antigen presenting cells: The present invention provides methods for evaluating the quality of a preparation of antigen presenting cells, such as dendritic cells. Assays for antigen-independent co-stimulation of T cells and for presentation of predetermined antigen by APCs are provided... Agent: Northwest Biotherapeutics, Inc.
20120252033 - Substance determining apparatus: The invention relates to a substance determining apparatus and method for determining a substance within a fluid. Particles attach to the substance and bind to a binding surface (30), wherein a particle release curve being indicative of a release of bound particles from the binding surface (30) is determined, and... Agent: Koninklijke Philips Electronics N.v.
20120252037 - Stimulatory auto-antibodies to the pdgf receptor as pathology marker and therapeutic target: An in vitro method for detecting the presence in a body sample of auto-antibodies for the PDGF receptor suitable for the diagnosis and prognosis of autoimmune diseases, in particular the systemic sclerosis and related diagnostic kits. Use of an inhibitor of ROS and/or Ras-ERK1/2 for the preparation of a medicament... Agent:
20120252038 - Steroid receptor assays: Methods for the detection, enumeration and analysis of circulating tumor cells expressing steroid receptors, particularly estrogen receptors are disclosed. These methods are useful for cancer screening and staging, development of treatment regimens, and for monitoring for treatment responses, cancer recurrence or the like. Test kits that facilitate the detection, enumeration... Agent:
20120252036 - Diagnostic tests for abnormal ovarian conditions: Methods and compositions, and a kit for diagnosing ovarian disorders including autoimmunity and ovarian cancer. Ovarian autoimmunity is associated with unexplained infertility or idiopathic premature ovarian failure that occurs in the absence of polyglandular disease. Methods and composition described herein are used to detect ovarian autoimmunity before the onset of... Agent: Rush University Medical Center
20120252040 - Kit for diagnosing prostate cancer and diagnosis method: The present invention relates to a kit and method for diagnosing prostate cancer, which use an antibody to prostate-specific antigen (PSA) to detect PSA in human urine. More specifically, the invention relates to a kit for diagnosing prostate cancer, which comprises an antibody to PSA and uses human urine as... Agent: Cell & Bio Co., Ltd.
20120252039 - Plasma kallikrein fragments as diagnostic biomarkers for lung cancers: Disclosed herein are diagnostic markers for lung cancer, isolated from serum glycoproteins. The disclosed diagnostic markers for lung cancer are specifically expressed only in the sera of lung cancer patients at high levels, and thus will be very useful for diagnosing lung cancer and estimating disease progression and treatment.... Agent: Protan Bio Co., Ltd.
20120252041 - Method of prognosis: The present invention relates to the use of soluble CD163 as a prognostic marker for the assessment of the risk for contracting a disorder, in particular for contracting diabetes and/or a liver disorder. The invention also relates to the use of CD163 as a prognostic marker for assessing lifetime expectancy.... Agent: Aarhus Universitet
20120252042 - Artificial feces: A composition to simulate feces. A method of using artificial feces to evaluate the efficacy of a cleaning product and/or cleaning procedure. A method of demonstrating the cleaning efficiency of a cleaning product and/or cleaning procedure using artificial feces.... Agent:
20120252043 - Blood coagulation time determination method and apparatus: The invention relates to a method for determining the coagulation time of a sample fluid containing blood components by means of a resonator whose vibration parameters are measured and then used as a basis for determining the sample fluid viscosity change, which resonator has an at least partially adhesive surface... Agent: Andreas Hettich Gmbh & Co. Kg
20120252044 - Controls and kit for thrombocyte activity tests: The present invention is in the field of coagulation diagnostics and relates to a kit and method for preparing controls for use in test methods for determining thrombocyte function.... Agent: Siemens Healthcare Diagnostics Products Gmbh
20120252045 - Method of assessing islet function: A method for assessing islet function comprising determining an oxygen consumption rate (OCR) of the islets; determining an islet index (II) of the islets; and determining an OCR/II ratio, wherein a high OCR/II ratio correlates with increased islet function. The methods may be performed on islets in vitro. In some... Agent:
20120252046 - Transdermal systems, devices, and methods for biological analysis: A transdermal test sensor includes a test chamber including a liquid, a reagent system in contact with the liquid, a housing containing the liquid, and a semipermeable membrane. The housing includes an opening, the semipermeable membrane is connected to the housing and covers the opening, and the housing and the... Agent: Bayer Healthcare LLC
20120252047 - Salicylic acid derivatives with fluorophores and method of making and using the same: wherein the fluorogenic group is directly linked to the moiety of formula I or indirectly linked thereto via a linkage structure. In addition, a method of preparing a latent fluorophore, a method of using the same and a kit containing the same are also introduced.... Agent: National Taipei University Of Technology
20120252048 - Compositions comprising a dehalogenase substrate and a contrast agent and methods of use: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one... Agent: Promega Corporation
20120252049 - Methods of detecting microorganisms and kits therefore: A method of detecting microorganisms in a test sample is provided. The method includes the steps of: a) incubating the test sample with a growth media to form an incubated sample, wherein the growth media includes an enzyme substrate and the enzyme substrate includes an enzymatically hydrolysable group and a... Agent:
20120252055 - Arrangement and method using microsensors for measuring cell vitalities: An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the... Agent:
20120252056 - Imaging method and system using substrate functionalization: An imaging system for analyzing fluorescent molecules in a sample, including a confocal microscope device, has a support in contact with at least a portion of the sample. In the system, the support surface in contact with the sample is functionalized so as to reduce the observation volume of the... Agent: Universite De Technologies De Troyes
20120252050 - Methods for assessing risk of bone fracture: The invention generally relates to methods for assessing risk of bone fracture. In certain embodiments, methods of the invention involve a) conducting an assay to determine a characteristic of keratinized tissue obtained from a mammal, b) analyzing at least one bone-fracture risk factor associated with the mammal, and c) correlating... Agent: Crescent Diagnostics Limited
20120252053 - Reagents and methods and systems using them: Certain embodiments described herein are directed to a reagent that includes an effective amount of an adsorber to remove interfering species present during heavy metal level measurement in a fluid sample. In some examples, the reagent can include an effective amount of an adsorber to remove a suitable amount of... Agent: Magellan Biosciences Point-of-care, Inc.
20120252054 - System for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp.: The present disclosure relates to methods of transforming various species of algae, for example, algae from the genus Scenedesmus and the genus Dunaliella, vectors and nucleic acid constructs useful in conducting such transformations, and recombinant algae, for example, Scenedesmus and Dunaliella produced using the vectors and methods disclosed herein.... Agent: Sapphire Energy Inc
20120252051 - Tlr8 transgenic animals: Provided herein are human Toll-like receptor 8 (TLR8)-expressing transgenic animals and methods of use thereof.... Agent: Dynavax Technologies Corporation
20120252059 - Fluorescent derivatives of polyamines, method for preparing same and applications thereof as diagnosis tools in the treatment of cancerous tumors: The invention relates to novel fluorescent derivatives of polyamines having a benzoxadiazole group, to a method for preparing the same and to the use thereof as diagnosis tools for emphasising the polyamine transport system in cancerous cells in order to adapt the treatment thereof, and thus for selecting patients carrying... Agent:
20120252057 - Method and device for detecting tumorous living cell tissue: The invention relates to a method and to an apparatus for recognizing tumorous living cell tissue. It furthermore relates to a method and to an apparatus for recognizing tumorous cell tissue at collected living cell tissue samples. In the method, electromagnetic radiation is emitted with local definition onto cell tissue... Agent:
20120252061 - Novel yeast strains for the production of alcohol: e
20120252060 - Self-renewing single human hematopoietic stem cells, an early lymphoid progenitor and methods of enriching the same: This invention relates to human hematopoietic stem cells. Specifically the invention relations to the identification of single human hematopoietic stem cells capable of long-term multilineage engraftment and self-renewal. The invention also relates to an early lymphoid progenitor with monocytic potential, including dendritic cell potential.... Agent:
20120252058 - System and method for the assessment of biological particles in exhaled air: A system and method for the deposition and analysis of a sample comprising exhaled particles. The sample may be deposited on a substrate and regions of interest comprising exhaled particles may be targeted using autofluorescence. Regions of interest comprising exhaled particles may then be interrogated to thereby generate a spectroscopic... Agent: Chemimage Corporation
20120252062 - Method for diagnosing and/or predicting the development of neurodegenerative diseases: The present invention relates to a method for diagnosing and/or predicting the development of neurodegenerative diseases; in the method, white blood cells are isolated and enriched or cultivated for forming colony-forming units, wherein CFU-M and other CFU are formed. Subsequently, the relative number of CFU-M formed in the previous cultivation(/enrichment... Agent: Eberhard-karls-universitat Tubingen Universitatsklinikum
20120252063 - Substituted anthraquinone dyes for cellular stains and enzyme detection: The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that... Agent: Biotium, Inc
20120252064 - Protease enzyme and uses thereof: The present invention is related to a fungal serine protease enzyme, which said enzyme has serine protease activity and comprises an amino acid sequence of Malbranchea ALKO4122 mature protease as defined in SEQ ID NO:18 or an amino acid sequence having at least 66% identity to the amino acid sequence... Agent: Ab Enzymes Oy
20120252066 - Methods of foam control: The invention relates to a method for decreasing foam formation as well as maximizing expression of a biosurfactant in a microorganism. The methods encompasses precipitating a biosurfactant from the microorganism which results in decreased form formation.... Agent:
20120252068 - Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes, Inc.
20120252067 - Systems for the expression of orthogonal translation components in eubacterial host cells: The invention related to compositions and methods for the in vivo production of polypeptides comprising one or more unnatural amino acids. Specifically, the invention provides plasmid systems for the efficient eubacterial expression of polypeptides comprising one or more unnatural acids at genetically-programmed positions.... Agent: The Scripps Research Institute
20120252069 - Process for the purification of glycoproteins: The present invention relates to a process for the purification of a glycoprotein comprising subjecting a liquid containing said glycoprotein to the steps of: a) reverse phase chromatography, b) size exclusion chromatography, and c) hydrophobic interaction chromatography. Also provided is a manufacturing process for producing a glycoprotein of interest.... Agent: Glycotope Gmbh
20120252070 - Biomass shock pretreatment: Methods and apparatus for treating biomass that may include introducing a biomass to a chamber; exposing the biomass in the chamber to a shock event to produce a shocked biomass; and transferring the shocked biomass from the chamber. In some aspects, the method may include pretreating the biomass with a... Agent: The Texas A&m University System
20120252071 - T7 rna polymerase variants with cysteine-serine substitutions: The present disclosure provide novel variants of T7 RNA polymerase. Embodiments of T7 variants, according to the instant invention, include a Cysteine-Serine substitution on position 723 of the amino acid sequence of the T7 polypeptide. Embodiments of T7 variants according to the instant invention have a DNA-dependent RNA polymerase enzymatic... Agent: Roche Diagnostics Operations, Inc.
20120252072 - Restriction/modification polypeptides, polynucleotides, and methods: The present invention relates to the discovery of a novel restriction/modification system in Caldicellulosiruptor bescii. The discovered restriction enzyme is a HaeIII-like restriction enzyme that possesses a thermophilic activity profile. The restriction/modification system also includes a methyltransferase, M.CbeI, that methylates at least one cytosine residue in the CbeI recognition sequence... Agent:
20120252073 - Method and composition for treating stubble: A method of decomposing stubble, which is crop residue left on the ground, and a composition for treating the stubble are disclosed. The method comprises treating the stubble with the composition comprising a) polysaccharide-degrading enzyme; b) wetting agent; and, optionally, c) water and allowing the treated stubble to remain on... Agent: Rhodia Operations
20120252074 - Pentose fermentation by a recombinant microorganism: The present invention provides methods and compositions suitable for use in the conversion of xylose to xylitol and xylulose, including nucleic acid constructs, recombinant fungal host cells, and related materials.... Agent: Codexis, Inc.
20120252075 - Microorganism and method for the fermentative production of an organic-chemical compound: The invention relates to a microorganism which produces and/or secretes an organic-chemical compound, wherein the microorganism has increased expression, compared to the particular starting strain, of one or more protein subunits of the ABC transporter having the activity of a trehalose importer, said microorganism being capable of taking up trehalose... Agent: Evonik Degussa Gmbh
20120252076 - Method for producing l-cysteine: A method for producing L-cysteine and the like is provided by developing a novel technique for improving bacterial L-cysteine-producing ability. The method includes the steps of culturing a bacterium belonging to the genus Escherichia which has L-cysteine-producing ability, and in which expression of a gene involved in sulfite reduction is... Agent:
20120252077 - Use of inducible promoters in the production of methionine: m
20120252078 - Microorganism which produces l-amino acid and method for producing l-amino acid using the same: The present invention relates to a microorganism belonging to the genus Escherichia sp. and a method for producing L-amino acid using the same. The microorganism belonging to the genus Escherichia sp. with sucrose assimilability and L-amino acid producing ability is obtained by introducing a gene encoding a sucrose assimilative microorganism-derived... Agent: Cj Cheiljetdang Corporation
20120252080 - Metabolic pathway targeting by transcription factor overexpression: The invention provides microorganisms such as cyanobacteria genetically engineered to express proteins that include transcription factor domains for upregulation of lipid biosynthetic pathways. In addition to expression a gene encoding a transcription factor domain protein, the recombinant microorganisms can express at least one exogenous gene that encodes a polypeptide for... Agent: Exxonmobil Research And Engineering Company
20120252079 - Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast: Promoter regions associated with the Yarrowia lipolytica diacylglycerol acyltransferase 2 (dgat2) gene are disclosed and have been found to be particularly effective for the expression of heterologous genes in yeast. These promoter regions will be useful for driving high-level expression of genes involved in the production of omega-3 and omega-6... Agent: E I Du Pont De Nemours And Company
20120252081 - Using cell debris generated from pha recovery for enhanced cell growth and biopolyester formation: The present invention relates to a process for producing biodegradable polymeric materials including polyhydroxyalkanoates (PHAs) by using the cell debris left from PHA recovery and purification. The process comprises: (a) cultivating PHA-producing microbial cells in a medium solution containing an organic carbon source to form PHAs that are accumulated in... Agent: Bio On S.r.l.
20120252082 - Fermentation process for controlling butanediol production: Methods for improving the efficiency of 2,3-butanediol fermentations are disclosed. More specifically methods of increasing the butanediol productivity from the anaerobic fermentation of a substrate comprising carbon monoxide or carbon monoxide and hydrogen by one or more caboxydotrophic acetogenic bacteria are disclosed. The method includes supplying a hydrogen depleted substrate... Agent: Lanzatech New Zealand Limited
20120252083 - Fermentation process for producing isopropanol using a recombinant microorganism: The invention provides, inter alia, methods for the production of acetone, isopropanol and/or precursors of acetone and/or isopropanol by microbial fermentation of substrates comprising CO, genetically modified microorganisms of use in such methods, nucleic acids suitable for preparation of genetically modified microorganisms, a novel alcohol dehydrogenase and nucleic acids encoding... Agent: Lanzatech New Zealand Limited
20120252084 - Enhanced pyruvate to acetolactate conversion in yeast: A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase activity. Additional manipulations to improve flux to acetolactate are reduced pyruvate dehydrogenase activity and reduced glycerol-3-phosphate dehydrogenase activity. Production of compounds having... Agent: E. I. Du Pont De Nemours And Company
20120252086 - Compositions comprising boosting polypeptide and starch degrading enzyme and uses thereof: The present invention provides a composition comprising a polypeptide comprising or consisting of an X46 domain and further a starch degrading enzyme and uses of such composition. The polypeptide comprising or consisting of an X46 domain can boost the activity of a starch-degrading enzyme.... Agent: Novozymes A/s
20120252085 - Method for the production of a fermentation product from a pretreated lignocellulosic feedstock: A method for obtaining a fermentation product from a sugar hydrolysate obtained from a feedstock containing hemicellulose, by (i) removing suspended fiber solids from said sugar hydrolysate to obtain a clarified sugar solution; (ii) fermenting xylose in the clarified sugar solution in a fermentation reaction with yeast to produce a... Agent: Iogen Energy Corporation
20120252087 - Bipolar flyback power supply: A device, system and method for treating biological cells includes a voltage source, a half-controlled bridge connected to the voltage source, and a load connected across the half-controlled bridge. The half-controlled bridge includes a first switch, a second switch, a first diode and a second diode. The load includes an... Agent: Board Of Regents, The University Of Texas System
20120252088 - Floating magnet probe for cell isolation: A cell isolation device with an inner freely floating magnetic probe to capture and collect biological cells, such as circulating tumor cells (CTCs), during immunomagnetic incubation provides a highly efficient, low cost method to collect target cells at a single cell level. A special membrane filter may be placed above... Agent:
20120252089 - Cytocompatible alginate gels: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.... Agent: Abbott Cardiovascular Systems Inc.
20120252090 - Heat resistant bioactive composition: A process for stabilizing a bioactive composition includes forming hydrogel matrix pores around protein molecules and reducing a water content within the hydrogel matrix pores while keeping the protein molecules biologically active.... Agent: Toyota Motor Engineering & Manufacturing North America, Inc.
20120252091 - Ligand functional substrates: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of... Agent: 3m Innovative Properties Company
20120252092 - Clostridium histolyticum recombinant collagenases and method for the manufacture thereof: The present invention relates to the production of recombinant collagenases, and in particular describes a method for the production of recombinant Clostridium histolyticum collagenases CoI characterized by a yield higher than approximately 140 mg/l of culture of said collagenases in soluble and biologically active form, collagenases produced by this method,... Agent: Abiel S.r.l.
20120252093 - Yarrowia esterase/lipase promoter regions for gene expression in yeast: Promoter regions associated with the Yarrowia lipolytica esterase/lipase (EL1) gene are disclosed and have been found to be particularly effective for the expression of heterologous genes in yeast. These promoter regions will be useful for driving high-level expression of genes involved in the production of omega-3 and omega-6 fatty acids.... Agent: E I Du Pont De Nemours And Company
20120252094 - Recombinant butyrylcholinesterases and truncates thereof: Isolated nucleic acids encoding polypeptides that exhibit butyrylcholinesterase (BChE) enzyme activity are disclosed, along with molecular criteria for preparing such nucleic acids, including codon optimization. Methods of preparing modified and/or truncated BChE molecules having selected properties, especially selective formation of monomers, are also described. Vectors and cells containing and/or expressing... Agent:
20120252095 - Alpha-amylase variants: The invention relates to a variant of a parent Termamyl-like alpha-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of... Agent: Novozymes A/s
20120252096 - Mutant proteinase with reduced self-cleavage activity and method of purification: The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method... Agent: Yale University
20120252097 - Therapeutic agents comprising pro-apoptotic proteins: The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax.... Agent:
20120252098 - Dissociation of product-complexed contaminants in chromatography: The invention provides methods and materials for using apatite chromatography supports to dissociate and remove contaminants that are complexed to biological products. The invention further provides materials and methods for dissociating aggregations of target biological molecules or improperly folded target molecules to improve purification of the target molecule.... Agent: Bio-rad Laboratories, Inc.
20120252099 - Immunogenic minicells and methods of use: The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.... Agent: Vaxiion Therapeutics, Inc.
20120252101 - Variants of bacillus sp. ts-23 alpha-amylase with altered properties: Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased themostability, reduced calcium dependence, increased washing/cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.... Agent: Danisco US Inc.
20120252100 - Mixed strain culture for the disposal of food waste, and food waste disposal method using same: The present invention relates to a mixed strain culture for the disposal of food waste, and more particularly, to a mixed strain culture for the disposal of food waste which has high degradation activity on cellulose, amylose, protein, and fat at a wide range of temperatures, pH levels, and salinities,... Agent:
20120252102 - Bioremediation systems, compositions, and methods: Systems, compositions, and methods for the anaerobic oxidative bioremediation of a contaminant contained within a treatment zone associated with a contaminated region. These systems, compositions, and methods may include a bioremediation formulation that includes a high-mobility oxidant, a low-mobility oxidant, and a nutrient source. The high-mobility oxidant may include a... Agent: Bioremediation Specialists, LLC
20120252103 - Apparatus, method and system for algae growth: The cultivation, by optimized growth and harvesting of algae derived bio-mass may provide useful feedstock for various products and processes. The present invention provides an apparatus that allows for the optimized growth and harvesting of algae within a photo-bioreactor. The photo-bioreactor may include a channel and a propulsion unit for... Agent:
20120252104 - Energy efficient temperature control of enclosed microalgae cultivator: The present invention provides methods and systems for energetically efficient and economically viable temperature regulation of the environment within commercial scale enclosed microalgae cultivators.... Agent: Elemen Cleantech, Inc.
20120252105 - Systems, apparatuses and methods of cultivating organisms and mitigation of gases: Cultivators and methods of cultivating microorganisms are provided. In some examples, a cultivator may include a retaining wall defining a cavity for retaining liquid and may also include a horizontally orientated frame at least partially positioned within the cavity and having media for supporting microorganisms. In other examples, the horizontal... Agent: Bioprocessh20 LLC
20120252106 - Use of protease variants: The present invention relates to protease variants, in particular to the use of the protease variants in hard surface cleaning. The present invention also relates to detergent compositions, such as dish wash compositions, comprising the protease variants, and the use of such compositions for removal of proteinaceous stains, especially boiled... Agent: Novozymes A/s
20120252107 - Bio-reactor system and method for composting food waste: A bio-reactor made according to this invention uses low temperature aerobic composting to decompose bio-compostable material. The reactor includes mixing paddles with wiper blades which aerate and agitate a set of plastic resin biochips which house microorganisms and cause the chips to come into contact with bio-compostable material. A water... Agent:
20120252108 - Pneumatically agitated and aerated single-use bioreactor: A single-use round flexible mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element comprising a radial flow impeller driven by an internal pneumatic vane motor is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are... Agent: Therapuetic Proteins International, LLC
20120252109 - Reagent cartridge for an assembly for selectively performing a clincial chemical test or an elisa test, use of said reagent cartridge and assembly: The invention relates to a reagent cartridge 10 for an assembly for selectively performing a clinical chemical test or an ELISA assay comprising a housing 11 having at least one cavity 12, 13, 14 that contains a reaction or diluting component and having a recess 15 in which a solid... Agent: Drg Instruments Gmbh
20120252110 - Cell culture apparatus: A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of... Agent: Nihon Kohden Corporation
20120252111 - Measuring system using optical waveguide, measuring device, measuring method, optical waveguide type sensor chip, and magnetic fine particle: According to one embodiment, a measuring system using an optical waveguide is provided. The measuring system has an optical waveguide, magnetic fine particles, a magnetic field applying unit, a light source and a light receiving element. The optical waveguide has a sensing area to which first substances having a property... Agent: Kabushiki Kaisha Toshiba
20120252112 - Thin-layer photobioreactor with high volume productivity: The invention relates to a photobioreactor (1) for the culture of cells, comprising a runoff substrate (2) having a surface inclined at an average slope along a direction of inclination (I-I) on which a solution flows and including an upstream side (21) and a downstream side (22), said solution comprising... Agent:
20120252115 - Methods and devices for nucleic acid purification: The invention provides pipette tip columns and automated methods for the purification of nucleic acids such as plasmids from unclarified cell lysates containing cell debris as well as methods for making and using such columns. The columns typically include a bed of medium positioned in the pipette tip column, above... Agent:
20120252113 - Use of triplex structure dna in transferring nucleotide sequences: The invention concerns a recombinant vector characterized in that it comprises a polynucleotide comprising a central initiation cis-active region (cPPT) and a termination cis-active region (CTS), the regions being of retroviral or retroviral-like origin, and the vector further comprising a predetermined nucleotide sequence (transgene or nucleotide sequence of interest) and... Agent:
20120252114 - Use of triplex structure dna in transferring nucleotide sequences: The invention concerns a recombinant vector characterized in that it comprises a polynucleotide comprising a central initiation cis-active region (cPPT) and a termination cis-active region (CTS), the regions being of retroviral or retroviral-like origin, and the vector further comprising a predetermined nucleotide sequence (transgene or nucleotide sequence of interest) and... Agent:
20120252116 - Fluid flow device containing nanotubes and method for cell trafficking using same: The present invention relates to device and method for cell trafficking. In particular, the invention relates to a fluid flow device in which the flow surface has nanotubes immobilized thereon. The nanotubes have molecules on their outer surface, which support cell rolling. Also provided is a method for separation of... Agent: Cornell University
20120252117 - Optimized messenger rna: The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common... Agent:
20120252118 - Plastic pressure vessel for biopharmaceutical applications and methods thereof: Described herein is a molded plastic pressure vessel for biopharmaceutical applications and methods thereof. The molded plastic pressure vessel has a surface area of at least 500 inches2 and comprises a polyphenylene oxide polymer; and at least one antioxidant.... Agent:
20120252119 - Methods for the collection and maturation of oocytes: The present invention relates to a method of producing an embryo from an oocyte by an assisted reproduction technology. The method includes (a) collecting an oocyte from an ovary of a subject in a collection medium comprising a first phosphodiesterase inhibitor and an agent that increases intracellular cAMP concentration in... Agent:
20120252120 - Diazonium salt modification of silk polymer: A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These... Agent: Trustees Of Tufts College
20120252121 - Culture method for amplifying large numbers of hair follicle stem cells in vitro: The present invention is a method, belonging to the field of cell culture, for amplifying a large numbers of hair follicle stem cells in vitro by using microspheres as carriers for cell culture and a revolving bottle as a fermentation tank for cell proliferation. The method is simple in its... Agent: Jilin University
20120252122 - Methods and compositions for increasing production of induced pluripotent stem cells (ipscs): Disclosed herein are methods and compositions for increasing yield of induced pluripotent stem cells (iPSCs).... Agent: Sangamo Biosciences, Inc.
20120252123 - Nucleic acid silencing sequences: The present invention features compositions and methods for introducing, into cells, nucleic acids whose expression results in chromosomal silencing. The nucleic acids are targeted to specific chromosomal regions where they subsequently reduce the expression of deleterious genes, or cause the death of deleterious cells. Where the nucleic acid sequence is... Agent: University Of Massachusetts
20120252124 - Compositions and methods for altering alpha- and beta-tocotrienol content using multiple transgenes: Preparation and use of isolated nucleic acids useful in altering the oil phenotype of plants are described. Isolated nucleic acids and their encoded polypeptides are described that alter the content of alpha-tocotrienol, beta-tocotrienol, or both, in transformed seeds and oil obtained from the transformed seeds. Expression cassettes, host cells and... Agent: E I Du Pont De Nemours And CompanyPrevious industry: Education and demonstration
Next industry: Chemistry: analytical and immunological testing
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