|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology August inventions list 08/12Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 08/30/2012 > 98 patent applications in 60 patent subcategories.
20120219940 - Abalone sperm preservation method for the aquaculture industry: The invention relates to a method for the preservation of sperm from abalone, in particular green abalone, Haliotis discus hannai and red abalone, H. rufescens: consisting in mixing the sperm with cryoprotectant containing propylene glycol, sucrose and egg yolk; freezing the sperm with cryoprotectant down to a temperature of approximately... Agent: Universidad Catolica Del Norte
20120219941 - Identification of oligonucleotides for the capture, detection and quantitation of hepatitis a viral nucleic acid: Hepatitis A virus-specific primers and probes derived from conserved regions of the hepatitis A virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes.... Agent: Chiron Corporation
20120219948 - Application of quantum dots for nuclear staining: Embodiments of a system, method, and kit for visualizing a nucleus are disclosed. A tissue sample is pretreated with a protease to permeabilize the nucleus, and then incubated with a nanoparticle/DNA-binding moiety conjugate. The DNA-binding moiety includes at least one DNA-binding molecule. The conjugate binds to DNA within the nucleus,... Agent: Ventana Medical Systems, Inc.
20120219950 - Assay systems for detection of aneuploidy and sex determination: The present invention utilizes detection of selected nucleic acid regions from pseudoautosomal regions to identify sex chromosomal aneuploidy and to determine fetal sex. Traditional methods of detecting sex chromosomal aneuploidies and performing sex determination typically involves some analysis of the Y chromosome. The assay systems of the present invention utilizing... Agent:
20120219952 - Carbapenemase and antibacterial treatment: The present invention relates to a carbapenemase and methods using said carbapenemase such as screening methods, predictive methods and therapeutic uses.... Agent:
20120219946 - Dna methylation markers associated with the cpg island methylator phenotype (cimp) in human colorectal cancer: Particular aspects confirm the existence of a CpG island methylator phenotype (CIMP) in colorectal cancer, and provide novel validated DNA methylation markers associated with CIMP. Additional aspects provide novel methods and compositions for: determining CIMP status in colorectal cancers, determining the relationship between CIMP status and other molecular features of... Agent: University Of Southern California
20120219954 - Genotyping: The object of the present invention is to provide a novel method that addresses the problem of differentiating large sets of genomic sequences. The invention relates to a method for genotyping N loci present in a sample in a target nucleic acid molecule, wherein each locus is located in a... Agent:
20120219953 - Method for detecting and quantifying poly(a) rna and mrna: The present invention relates to a method for detecting and/or for quantifying poly(A) RNA and/or mRNA, wherein a poly(dT) oligonucleotide which features a fluorescent dye and also a quencher is hybridized to the nucleic acid to be detected. Non-hybridized poly(dT) oligonucleotide is degraded by an added nuclease, and as a... Agent: Qiagen Gmbh
20120219949 - Method of detecting methylated dna in sample: In order to simply obtain a methylated DNA sample, a method including bringing a sample which may include methylated DNA into contact with a protein capable of binding to methylated DNA to bind the methylated DNA in the sample to the protein, bringing the sample obtained into contact with at... Agent: Sysmex Corporation
20120219942 - Methods employing mcra to detect 5-methyl cytosine: The invention provides methods for using the rMcrA protein, and derivatives thereof, for direct or semi-direct determination of the methylation status of CpG dinucleotides in methyl-CpG island sequences of interest.... Agent: Brookhaven Science Associates, LLC
20120219947 - Methods for forming mixed droplets: The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet.... Agent: Raindance Technologies, Inc.
20120219943 - Methods of prognosis and diagnosis in chronic heart failure: The present disclosure provides methods of diagnosing chronic heart failure in patients by detecting the presence and amounts of biomarkers of heart failure in samples from the patients. Such biomarkers may be used to develop a more accurate prognosis for a patient with heart failure, or to accurately diagnose a... Agent: Abbott Laboratories
20120219944 - Myh14 as causative gene responsible for complex phenotype of peripheral neuropathy, myopathy, hearing loss and hoarseness, and diagnostic method and kit for the complex phenotype using the same: The present invention newly identified a missense mutation in the MYH14 gene as a cause responsible for a complex phenotype of peripheral neuropathy, myopathy, hearing loss, and hoarseness. Further, the present invention provides a method for diagnosing inherited neuromuscular disorders showing a complex phenotype of peripheral neuropathy, myopathy, hearing loss,... Agent: Ewha University - Industry Collaboration Foundation
20120219951 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Canon Kabushiki Kaisha
20120219955 - Thd primer target detection: The present invention relates to the detection of a target nucleic acid sequence using a target hybridization and detection primer (THD primer). The present invention allows for both a target amplification and a signal amplification by introducing a label into a primer used in PCR reactions, ensuring a real-time target... Agent: Seegene, Inc.
20120219945 - Use of single-stranded binding protein in amplifying target nucleic acid: A PCR composition is described that includes a single-stranded nucleic acid binding protein, e.g. the G5p protein, that binds cooperatively to single-stranded nucleic acids such as primers and/or probe or single stranded nucleic acid templates and shields them from nuclease degradation. The single-stranded nucleic acid binding protein complex also prevents... Agent: Samsung Techwin Co., Ltd.
20120219957 - Method of preparing a reaction mixture and related products: The invention relates to a method of preparing a reaction mixture for Polymerase Chain Reaction (PCR) assay and a solution set for PCR. The method comprises providing a sample solution comprising a biological sample to be amplified in said PCR assay and first colorant providing the solution a first color,... Agent: Finnzymes Oy
20120219958 - Microrna signatures differentiating uterine and ovarian papillary serous tumors: The invention provides a papillary serous miRNA signature and methods for determining the identity, origin, and stage, of concurrent endometrial and ovarian papillary serous tumors. Exemplary origins of concurrent endometrial and ovarian tumors include, but are not limited to, the uterus, ovary, fallopian tubes, and peritoneum.... Agent: Yale University
20120219956 - Ngal for diagnosis of renal conditions: Use of serum neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker, alone or in conjunction with creatinine to aid in the diagnosis of renal conditions such as acute tubular necrosis and acute renal failure, and a method and a kit for assigning a diagnosis of acute tubular necrosis or acute renal... Agent:
20120219959 - Targeted chromosomal mutagenesis using zinc finger nucleases: The present invention provides for a method or methods of targeted genetic recombination or mutagenesis in a host cell or organism, and compositions useful for carrying out the method. The targeting method of the present invention exploits endogenous cellular mechanisms for homologous recombination and repair of double stranded breaks in... Agent:
20120219960 - Methods using pores: The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The... Agent: Isis Innovation Limited
20120219962 - Human embryonic stem cell methods and podxl expression: A method of identifying an undifferentiated human embryonic stem cell in a sample which may contain such cells, the method comprising identifying the cell or cells within the sample that express podocalyxin-like protein (PODXL) on their surface. A method of isolating an undifferentiated human embryonic stem cell from a sample... Agent: Agency For Science, Technology & Research
20120219961 - Methods of running assays using intrachain fluorophore-quencher fret-aptamers: The present invention describes methods for the production and use of single chain (single-stranded) fluorescence resonance energy transfer (“FRET”) DNA or RNA aptamers containing fluorophores (F) and quenchers (Q) at various loci within their structures, such that when its specific matching analyte is bound and the FRET-aptamers are excited by... Agent: Pronucleotein Biotechnologies, LLC
20120219967 - Cholinergic/serotoninergic receptor and uses thereof: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.... Agent:
20120219968 - Gpcr expressing cell lines and antibodies: The present invention provides expression vectors that facilitate high levels of expression of GPCR proteins. Encompassed by the invention are methods and compositions for recombinant cell lines expressing GPCR proteins with the aid of the expression vectors of the instant invention. The recombinant cell lines of the instant invention express... Agent: Multispan, Inc.
20120219969 - Marker for neuromyelitis optica: The present invention provides for methods and materials for diagnosing and treating neuromyelitis optica (NMO).... Agent:
20120219970 - Methods for modulating macrophage proliferation in ocular disease using polyamine analogs: Methods for modulating macrophage proliferation in an individual afflicted with or at risk for an ocular disease such as ARMD are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including ARMD. The invention also... Agent: Pathologica LLC
20120219971 - Transcription factor-based biosensors for detecting dicarboxylic acids: The invention provides methods and compositions for detecting dicarboxylic acids using a transcription factor biosensor.... Agent: The Regents Of The University Of California
20120219963 - Derivatives of uridine phosphate and their uses in protein binding assays: The present invention relates to compounds and their use in competitive protein binding assays, for example for use with glycosyl transferase and/or glycoprocessing proteins. The present application also provides kits and apparatuses for use in the assays. In particular, the present invention provides a compound of the formula (I): wherein... Agent:
20120219964 - Bacterial atp synthase binding domain: This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts... Agent:
20120219965 - Masp 2, a complement-fixing enzyme, and uses for it: The invention relates to the discovery and characterization of mannan binding lectin-associated serine protease-2 (MASP-2), a new serine protease that acts in the MBLectin complement fixation pathway.... Agent: Helion Biotech Aps
20120219966 - Method and kit for measuring component to be assayed in specimen (as amended): Methods for measuring a component to be measured, which comprise: reacting, in the presence of a fatty acid alkanolamide, a component to be measured in a specimen with a first antibody which binds to the component to be measured; then reacting a labeled second antibody, in which a label is... Agent: Kyowa Medex Co., Ltd.
20120219972 - Diagnosis and treatment of ehrlichiosis: The present invention provides an isolated Ehrlichia peptide and therapeutic and diagnostic uses therefor.... Agent: The Board Of Regents Of The University Of Texas System
20120219974 - Distinguishing assay: The current invention comprises a method for determining of an antibody against a drug antibody in a sample using an immunoassay comprising a capture drug antibody and a tracer drug antibody, wherein the method comprises providing i) a capture drug antibody, which is the drug antibody conjugated to a solid... Agent:
20120219975 - Galactose-alpha-1,3-galactose-macromolecule conjugates and methods employing same: Methods and reagents are disclosed for conducting assays for IgE. Embodiments of the present reagents comprise a conjugate of a macromolecule and a compound comprising a galactose-α-1,3-galactose epitope. Embodiments of the present methods are directed to determining the presence and/or amount of an IgE specific for a galactose-α-1,3-galactose epitope in... Agent: Siemens Healthcare Diagnostics Inc.
20120219973 - Immunoregulation in cancer, chronic inflammatory and autoimmune diseases: The present invention primarily relates to a method for analyzing the amount of immunoregulatory integrin binding factors and/or patient endogenous antibodies which are directed against such factors, the factors having the capacity to modulate the immune functions in a. subject suffering from cancer or inflammatory or autoimmune diseases, by utilizing... Agent: Canimguide Therapeutics Ab
20120219976 - Reducing the risk of human anti-human antibodies through v gene manipulation: The present embodiments relate to methods of identifying and creating human or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for... Agent: Amgen Fremont Inc.
20120219977 - Sequences, antibodies, methods and kits for detection and in vitro assay of periostin, in order to provide a diagnosis, follow-up or prognosis of diseases and biological phenomena involving periostin: Detection sequences of periostin having from 6 to 30 amino acids and which include all or part of peptide sequence SEQ ID No. 1, SEQ ID No. 2 or SEQ ID No. 3, or a homologous peptide sequence. Antibodies suitable for specifically recognizing minimally one of these detection sequences, including... Agent:
20120219978 - Method and system for detection of chloramphenicol: Fast and simple method of detecting the presence of chloramphenicol, a harmful compound if present in food products. The method makes use of a mutant chloramphenicol acetyltransferase (CAT) and a fluorophore-linked chloramphenicol in a system where chloramphenicol and the fluorophore-linked chloramphenicol competes for the active site of the mutant CAT.... Agent:
20120219979 - Pon1 as a marker for heart failure: Provided herein are methods for assessing the risk a test subject with heart failure has of experiencing a major adverse cardiac event, requiring revascularization, requiring a heart transplant, requiring unscheduled hospitalization for heart failure, progression of heart failure status, or any combination thereof. Also provided herein are methods for assessing... Agent: The Cleveland Clinic Foundation
20120219983 - method for obtaining structural and functional information on proteins, based on polarization fluorescence microscopy, and a device implementing said method: The invention pertains to a method of obtaining structural and functional information on proteins, based on polarization fluorescence microscopy, which comprises subjecting a protein tagged with a fluorophore to two- or multi-photon fluorescence microscopy, whereas the observed protein is irradiated with a laser beam with light of at least two... Agent: Centrum Vyzkumu Globalni Zmeny Av Cr, V.v.i.
20120219981 - Mechanical stretching device: The present invention is directed to a mechanical stretching device, comprising a stretchable substrate comprising at least one stretching material area within which a stretching material is placeable, and two engagement areas being located at opposite ends of the stretchable substrate, respectively, two movable elements, each of which comprising an... Agent:
20120219984 - Method for the anaerobic treatment of a wastewater and associated device: The invention relates to a device and a method for anaerobic treatment of wastewater in a biological reactor (100) involving at least one stabilised bacteria species including the following steps: measuring (150) a concentration, in an area linked to the reactor, of a reaction product inhibiting said at least one... Agent: Veolia Water Solutions & Technologies Support
20120219982 - Methods for selecting active agents for cancer treatment: The present invention provides methods for individualizing chemotherapy, and particularly methods for individualizing neoadjuvant chemotherapy. The present invention provides methods for predicting a cancer patient's response to neoadjuvant chemotherapy, including assessing the probability of a positive response upon treatment with candidate agents prior to surgery. In various aspects, the invention... Agent: Precision Therapeutics, Inc.
20120219980 - System and method for pipetting guidance: Embodiments are described wherein systems and methods for assisting with pipette-based substance transport between two or more trays is disclosed. A controller may be operatively coupled to each of a first matrix of lights and a second matrix of lights and configured to selectively and discretely illuminate one or more... Agent: Willow Garage, Inc.
20120219985 - Method for the toxicity assessments of nano-materials: The present invention relates to a method for the toxicity assessment of nano-materials, and more specifically, it is relates to an objective, reproducible and accurate assessment method for the unbiased toxicity testings of nano-materials, which minimize artifacts of the conventional methods for the toxicity assessment of the nano-materials by considering... Agent:
20120219987 - Device for electroporation and lysis: There is provided a membrane disruption device including a sample container and an electrode assembly. The sample container includes a sample-containing space defined by a containing surface and configured for containing a cellular-material comprising fluid, wherein the sample-containing space includes at least one membrane disruption space. The electrode assembly including... Agent:
20120219986 - Universal fixative: This invention provides compositions and methods for fixing biological samples, particularly fecal samples used in the diagnosis of parasitic infection. The fixative composition of the present invention includes a zinc salt, an organic acid and water and permits staining of biological samples without use of toxic compounds, such as formaldehyde... Agent: Medical Chemical Corporation
20120219988 - composition for polymerizing a protein: The present invention provides a highly efficient method of polymerizing a protein and a composition of polymerizing a protein. For example, the present invention provides a method comprising contacting a tyrosinase derived from nameko mushroom (Pholiota microspora) with a protein to be polymerized. The present invention also provides a composition... Agent: Sugiyo Co., Ltd.
20120219989 - Polypeptides having glucoamylase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s
20120219991 - Clonal expansion of b cells: The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are useful for inducing... Agent:
20120219990 - Pre-filtration adjustment of buffer solutes: Herein is reported a tangential flow filtration method with a pre-filtration solute concentration adjustment in order to ensure a defined concentration of the components of the solution after tangential flow filtration.... Agent:
20120219992 - Method and composition for crystallizing a family c gpcr: Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled receptor (GPCR), wherein the first portion comprises the TM1, TM2 and TM3, regions of the GPCR; b) a stable,... Agent:
20120219993 - Method of producing microbial intracellular products from volatile fatty acids: A method for producing microbial intracellular products, and more particularly a method of producing microbial intracellular products from volatile fatty acids derived from organic waste is provided. The method of producing microbial intracellular products from volatile fatty acids in a multi-stage continuous high-cell-density culture bioreactor system includes the steps of:... Agent: Korea Advanced Institute Of Science And Technology
20120219994 - Prophage element-free bacteria: The present invention provides a bacterium having a genome that is genetically engineered to be smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a commercial product more efficiently. The present invention also provides methods for deleting genes and other DNA sequences... Agent:
20120219995 - Method for producing an l-amino acid: A method for producing an L-amino acid which includes the steps of culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid producing ability in a medium to produce and accumulate an L-amino acid in the medium, and collecting the L-amino acid from the medium, wherein the... Agent:
20120219996 - Method for producing l-amino acids using bacteria of the enterobacteriaceae family: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.... Agent:
20120219997 - Strains of escherichia coli modified by metabolic engineering to produce chemical compounds from hydrolyzed lignocellulose, pentoses, hexoses and other carbon sources: The present invention refers to the new Escherichia coli strains denominated JU15, JU15A, LL26 and MS04 and their derivatives that produce metabolites, particularly D-lactate, L-lactate or ethanol, with high yield and selectivity from a wide variety of carbon sources, such as culture media with a high xylose content (as the... Agent:
20120219998 - Producing a trimethylpentanoic acid using hybrid polyketide synthases: The present invention provides for a polyketide synthase (PKS) capable of synthesizing trimethylpentanoic acid. The present invention also provides for a host cell comprising the PKS and when cultured produces the trimethylpentanoic acid. The present invention also provides for a method of producing the trimethylpentanoic acid, comprising: providing a host... Agent: The Regents Of The University Of California
20120220000 - Engineering microbes for efficient production of chemicals: This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic... Agent:
20120219999 - Microorganisms for c4-dicarboxylic acid production: The present invention relates to isolated polypeptides having bicarbonate transporter activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, and methods of producing C4-dicarboxylic acids, such as... Agent: Novozymes, Inc.
20120220001 - Method for the enzymatic production of 3-hydroxy-s-methylbutyric acid from acetone and acetyl-coa: Described is a method for the production of 3-hydroxy-3-methylbutyric acid by enzyme-catalyzed covalent bond formation between the carbon atom of the oxo group of acetone and the methyl group of a compound which provides an activated acetyl group. Also described are recombinant organisms which produce 3-hydroxy-3-methylbutyric acid, and related compositions... Agent:
20120220002 - Recombinant halohydrin dehalogenase polypeptides: The present disclosure provides engineered halohydrin dehalogenase (HHDH) polypeptides having improved enzyme properties as compared to the wild-type HHDH enzyme HheC and other reference engineered HHDH polypeptides. Also provided are polynucleotides encoding the engineered HHDH enzymes, host cells capable of expressing the engineered HHDH enzymes, and methods of using the... Agent: Codexis, Inc.
20120220003 - Method for continuously separating organic materials of interest from fermentation: A method for continuously separating organic materials of interest from fermentation, in particular lactic or alcoholic fermentation, by flash evaporation is described. The method can make it possible to avoid inhibiting the fermentation reaction and to obtain high yields and productivity.... Agent: Rhodia Operations
20120220004 - Ethanol production from ocean biomass: An object of the present invention is to provide a method for producing ethanol from polysaccharide alginate contained in a large amounts in brown algae, using the alginate assimilation capacity of the Sphingomonas sp. strain A1 and the strong ethanol production capacity of bacteria such as Zymomonas mobilis. Specifically, a... Agent: Kyoto University
20120220005 - Method for producing ethanol from lignocellulosic biomass:
20120220006 - Hydrogen production from microbial strains: The present invention is directed to a method of screening microbe strains capable of generating hydrogen. This method involves inoculating one or more microbes in a sample containing cell culture medium to form an inoculated culture medium. The inoculated culture medium is then incubated under hydrogen producing conditions. Once incubating... Agent: University Of Washington
20120220007 - Production of secreted bioproducts from photosynthetic microbes: The invention provides new compositions and methods for the production of useful chemicals from recombinant photosynthetic bacteria, such as recombinant cyanobacteria. Embodiments of the invention provide for the genetic engineering of photosynthetic bacteria to express and secrete a product of interest, such as hexose sugars or lactate. More specifically, the... Agent: President And Fellows Of Harvard College
20120220009 - Cross-flow membrane filtration-based process for protein recovery: The present methods relate to the isolation and concentration of proteins using cross-flow membrane filtration, and to proteins produced by such methods. A feature of the method is that the protein of interest is retained by a cross-flow membrane under certain conditions that promote retention, while under other condition the... Agent: Danisco US Inc.
20120220008 - Nucleic acids and polypeptides involved in the production of cryptophycin: The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins.... Agent:
20120220010 - Photosynthetic hydrogen production from the green alga chlamydomonas reinhardii: The present invention relates generally to hydrogen production for use in fuel cells, foodstuffs and chemical production, and more particularly, to biologically and photosynthetically produced hydrogen. Specifically, disclosed is a method for producing bacteria and green alga that can produce hydrogen in quantities that exceed four hundred percent of the... Agent:
20120220011 - Unstructured recombinant polymers and uses thereof: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous... Agent: Amunix Operating Inc.
20120220012 - Maize cellulose synthases and uses thereof: The invention provides isolated cellulose synthase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering cellulose synthase levels in plants. The invention further provides recombinant expression cassettes, host cells, and transgenic plants comprising said nucleic acids.... Agent: Pioneer Hi Bred International Inc
20120220013 - Covalent tethering of functional groups to proteins and substrates therefor: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two... Agent: Promega Corporation
20120220014 - Novel polypeptide having esterase activity and recombinant esterase and use thereof: Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.... Agent: Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg
20120220015 - Compositions and methods for production of aglycosylated plasminogen: Compositions and methods for producing aglycosylated plasminogen (PLG) polypeptides and fragments and variants thereof are provided. Compositions of the invention include isolated nucleic acid molecules encoding aglycosylated PLG polypeptides in which the asparagine (Asn) residue corresponding to residue Asn-289 of the mature human PLG polypeptide has been substituted with an... Agent: Biolex Therapeutics
20120220016 - Pectin lyase, pectin lyase gene, enzyme preparation, and method for producing single cells of plant tissue: To provide a pectin lyase and a gene for a pectin lyase which can be used in an enzyme preparation for processing plant tissue, and which possesses sufficient maceration activity even under highly acidic conditions. Isolation and purification of a pectin lyase and a gene for a pectin lyase having... Agent:
20120220017 - Method for manufacturing red mold dioscorea: The present invention discloses a method for manufacturing red mold dioscorea, and the method comprises the following steps: washing and cutting a fresh dioscorea into pieces with a specific dimension; drying the pieces of the fresh dioscorea for making the dried dioscorea contain a specific water content and a specific... Agent: Sunway Biotech Co., Ltd.
20120220018 - Method for nutrient pre-loading of microbial cells: A method is provided for supporting the growth of selected microbial cells and for obstructing the growth of contaminants in a non-sterile system. In the method, the microbial cells are pre-loaded with a surplus amount of a chosen nutrient, such as phosphorus, other macronutrients, or micronutrients. Further, the chosen nutrient... Agent: General Atomics
20120220019 - Air collector with functionalized ion exchange membrane for capturing ambient co2: Methods, systems, apparatuses and compositions for extracting selected gases from a gas stream are provided. In some embodiments the invention involve a process of bringing a gas stream in contact with a primary sorbent, releasing a selected gas from the primary sorbent to create a selected gas-enriched gas mixture, and... Agent:
20120220020 - Multichamber photobioreactor: A multichamber photobioreactor comprises at least one cultivation chamber and at least one temperature control chamber and is characterized in that at least one outer surface of the cultivation chamber comes in contact with the temperature-controlling medium in such a way that at least 50 percent of at least one... Agent: Wacker Chemie Ag
20120220021 - Herbicide resistant organisms: Disclosed herein are transformed non-vascular photosynthetic organisms that are herbicide resistant, nucleotides and vectors useful in conducting such transformations, and transformed strains produced by such transformations.... Agent: Sapphire Energy ,inc.
20120220022 - High throughput multichannel reader and uses thereof: The present invention relates generally to the field of high content screening of particles, e.g., cells in a flow cytometric system. In particular, the present invention relates to devices, methods and systems to obtain line-scan images of particles, e.g., cells, of a plurality of different samples simultaneously, where the line-scan... Agent: Trustees Of Boston University
20120220023 - Analysis device with transducer stiffening elements: Disclosed herein is an analysis device for use with an external testing apparatus to detect the presence of an analyte in a test sample. The device comprises a transducer formed of a layer of pyroelectric or piezoelectric material sandwiched between first and second electrode layers, the transducer being arranged to... Agent: Vivacta Ltd.
20120220026 - Gas temperature/humidity regulation method and gas supply device: When a gas containing an amount of water vapor equivalent to that contained in the gas at the desired temperature Td and the desired relative humidity Hd is assumed, and the temperature of the gas when its relative humidity is 100% is defined as an intermediate target temperature Tc, Tc... Agent: Hitachi High-technologies Corporation
20120220025 - Process for accelerated capture of carbon dioxide: The present invention generally relates to the removal of carbon dioxide from a gas stream, particularly a flue gas, hydrogen gas from a reformer, natural gas, or gas from a cement kiln. Immobilized enzymes for use in carbon capture and other systems are also disclosed.... Agent: Akermin, Inc.
20120220024 - Reaction vessel: A reaction vessel assembly for use with thermal cyclers is described. The assembly includes a reaction vessel and a casing defining a cavity. In a first configuration, the casing receives the reaction vessel within the cavity, to act as a protective casing for the reaction vessel. In a second configuration,... Agent: Epistem Limited
20120220027 - Magnetically coupled system for mixing: The invention provides a mixing system comprising a magnetically coupled drive system and a foil for cultivating algae, or cyanobacteria, in an open or enclosed vessel. The invention provides effective mixing, low energy usage, low capital expenditure, and ease of drive system component maintenance while maintaining the integrity of a... Agent: Algenol Biofuels Inc.
20120220028 - Enhancer for promoter, and use thereof: Disclosed is an enhancer for a viral promoter such as a promoter that can induce expression selectively and strongly in immunocompetent cells (e.g., lymphocytes) or blood cells. It is found unexpectedly that an intron has the above-mentioned enhancer activity. Thus, it is found that an enhancer for a promoter, which... Agent: The Research Foundation For Microbial Diseases Of Osaka University
20120220029 - Mutant sox proteins and methods of inducing pluripotency: There is presently provided mutant Sox2, Sox7 and Sox17 proteins that have acquired or increased ability to induce pluripotency in a partially differentiated or fully differentiated cell. Sox7 and Sox17 are mutated to resemble in part Sox2, or Sox2 is mutated to resemble in part Sox7 or Sox17. In one... Agent: Agency For Science, Technology And Research
20120220031 - Culture substrate for human pluripotent stem cells and use thereof: The present invention provides a culture substrate which enables maintenance culture of human pluripotent stem cells in a pluripotent state under a feeder-free culture environment, and a culture method of human pluripotent stem cells using the culture substrate. By seeding human pluripotent stem cells dissociated into single cells at a... Agent:
20120220030 - Enhanced efficiency of induced pluripotent stem cell generation from human somatic cells: A substantially pure population of human somatic cells that have enhanced potential to become induced pluripotent stem cells (iPS cells) is provided. Also provided are methods for generating this population of cells and methods for generating iPS cells from this population of cells.... Agent:
20120220032 - Optimizing culture medium for cd34<+> hematopoietic cell expansion: The present invention provides a method of determining the optimal composition of a serum-free, eukaryotic cell culture medium supplement, using 2-level factorial design and the steepest ascent method. The invention further provides a method of making a serum-free eukaryotic cell culture medium supplement and the generated thereof. The invention further... Agent: Sino Cell Technologies Inc.
20120220033 - Inhibition of viral gene expression using small interfering rna: The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES)... Agent: Somagenics, Inc.
20120220034 - Methods for reprogramming cells and uses thereof: Described herein are methods for cell dedifferentiation, transformation and eukaryotic cell reprogramming Also described are cells, cell lines, and tissues that can be transplanted in a patient after steps of in vitro dedifferentiation and in vitro re-programming In particular embodiments the cells are Stem-Like Cells (SLCs), including Neural Stem-Like Cells... Agent: New World Laboratories Inc.
20120220035 - Temperature-responsive co-polymers and uses thereof: This disclosure relates to temperature-responsive co-polymers, such as poly(N-isopropylacrylamide-co-hydroxypropyl methacrylate-co-3-trimethoxysilypropyl methacrylate). The disclosure also relates to polymeric films formed from these co-polymers and particular applications of these polymeric films, particularly in the cell culture field. More specifically, the present disclosure relates to the use of these polymeric films in the... Agent: The University Of Manchester
20120220036 - Media, kits, systems and methods for the micropropagation of bamboo: Disclosed herein are media, kits, systems and methods for achieving micropropagation of bamboo on a commercially-relevant scale.... Agent: Boo-shoot Gardens, LLC
20120220037 - Methods and materials for producing transgenic artiodactyls: Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells... Agent:08/23/2012 > 96 patent applications in 59 patent subcategories.
20120214148 - Polyfluoroalkylphosphonic acid salt emulsifier and mold-releasing agent comprising the same as active ingredient: Disclosed is an emulsifier comprising, as an active ingredient, a polyfluoroalkylphosphonic acid salt represented by the general formula: CnF2n+1(CH2CF2)a(CF2CF2)b(CH2CH2)cP(O)(OM1)(OM2), wherein M′ is a hydrogen atom, an alkali metal, an ammonium base, or an organic amine base, M2 is an alkali metal, an ammonium base, or an organic amine base, n... Agent: Unimatec Co., Ltd.
20120214149 - Cyclic implant perfusion, cleaning and passivation process and implant produced thereby: A method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant, and the implant produced by such treatment. A system wherein the rate of pressure... Agent:
20120214150 - Stirring method, cell culture method, stirring apparatus, and cell culture apparatus: A stirring method includes measuring, with respect to cells which adhere to an inner surface of a culture vessel to be cultured, an ease of peeling between the culture vessel and the cell and an ease of peeling between the mutual cells, and performing a stirring process on the cells... Agent: Nikon Corporation
20120214153 - Detection of an analyte in a sample: There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte to be detected, and at least a microstructure associated with the first measurement channel. When the mechanisms are in use,... Agent: International Business Machines Corporation
20120214151 - Detection of hiv-related proteins in urine: A method for detecting HIV infection in a mammal is disclosed. The method contains the steps of isolating exosomes from a urine sample of a mammal and detecting the presence of HIV-specific biomarker in said isolated exosomes. A method for diagnosing a mammal with an HIV-associated disease, in particular, HIV-associated... Agent: Morehouse School Of Medicine
20120214155 - Diagnostic assays for chordopoxviruses: This disclosure relates to compositions and methods of their use in detection and identification of a chordopoxvirus in a sample, such as diagnosis of an infection in a subject. The compositions and methods allow for detection and identification of all non-avian low-GC content chordopoxviruses, identification of most known high-GC content... Agent:
20120214154 - Genetically engineered biological indicator: The disclosed technology relates to a genetically engineered biological indicator, comprising: at least one test organism and at least one reporter gene suitable for producing an indicator enzyme, the reporter gene being taken up by the test organism; and at least one repressor gene that inhibits expression of the reporter... Agent: American Sterilizer Company
20120214152 - Rnascope® hpv assay for determining hpv status in head and neck cancers and cervical lesions: The present invention provides a method and a kit for determining whether a head and neck cancer is HPV-related. In one embodiment, an RNAscope® HPV assay was designed to detect the presence of E6/E7 mRNA of certain high-risk HPV subtypes related to head and neck cancer. The present invention also... Agent:
20120214156 - Device including a dissolvable structure for flow control: A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A retainment region can include a container such as a retainment region,... Agent: Life Technologies Corporation
20120214157 - Method to generate or determine nucleic acid tags corresponding to the terminal ends of dna molecules using sequences analysis of gene expression (terminal sage): We describe a method of providing an indication of an instance of expression of a gene, the method comprising the steps of: (a) providing a complementary deoxyribonucleic acid (cDNA) having a terminus comprising a terminal transcribed sequence of a gene; (b) linking the cDNA to an linker sequence thereby forming... Agent: The Agency For Science, Technology And Research
20120214162 - Assay methods using dna binding proteins: Assay methods for preparing a biomolecule analyte includes hybridizing a sequence specific oligonucleotide probe to a biomolecule template and reacting the resulting analyte with a binding moiety.... Agent: Nabsys, Inc.
20120214163 - Disease-associated genetic variations and methods for obtaining and using same: The invention provides a comprehensive, rapid, unbiased, and accurate method for identifying and/or discovering disease-associated genetic variations, e.g., disease-associated variations. The present invention further provides novel disease-associated genetic variations for use as genetic markers of disease, e.g., cancer. The invention further provides methods for assessing an individual's risk for developing... Agent: Brigham & Women's Hospital
20120214164 - Dna sequencing method: A method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and processes along the polynucleotide. The detection of a conformational change may be carried out by measuring changes in a fluorophore bound to the enzyme.... Agent: Gen-probe Incorporated
20120214161 - Method of detecting or quantitating endogenous wheat dna and method of determining contamination rate of genetically modified wheat in test sample: An object of the present invention is to discover an endogenous wheat sequence satisfying the conditions of: a) it is universally present in varieties of wheat, b) the amount present (detected amount) is not affected depending on the wheat variety, c) even if other grains are present, only wheat can... Agent: Nisshin Seifun Group Inc.
20120214165 - Methods and compositions for the diagnosis and treatment of thyroid cancer: Methods for detecting, diagnosing and monitoring thyroid cancer in a subject are described comprising measuring in a sample from the subject markers including Ep-ICD and EpEX. The invention also provides kits and compositions for carrying out the methods of the invention.... Agent:
20120214160 - Methods, compositions, and kits for detecting rare cells: Disclosed herein are methods for identifying rare cells containing particular markers and/or alleles from biological samples that have not been substantially pre-processed (e.g., unprocessed whole blood). The methods described herein provide a system for digital enrichment of target cells from a biological sample and detection of such target cells, thereby... Agent: Life Technologies Corporation
20120214158 - Mutational analysis: A method for analysing genetic mutations, and in particular single nucleotide polymorphisms (SNPs) and/or somatic mutations, is described, as well as methods for preferentially amplifying one allelic form compared with another form. The methods use an oligonucleotide probe which hybridises to a first allele with a lower melting temperature (Tm)... Agent: Epistem Limited
20120214166 - Probe for detecting polymorphism in egfr gene and use of the probe: m
20120214159 - Systems and methods for obtaining and managing sequencing data: Systems and methods for biological sample processing are described. A production line extracts genomic DNA from a biological sample, amplifies target components of the sample and produces sequence data for markers from the amplified components. The markers are associated with tests identified in a requisition received with the sample and... Agent:
20120214167 - Apparatus for bio-automation: wherein the plurality of processing modules includes a component isolation module capable of facilitating a separation process within the cartridge, a manipulator module capable of facilitating the movement of fluids within the cartridge; and an optical module capable of interacting optically with the cartridge.... Agent: Iti Scotland Limited
20120214170 - Cellular depletion of biomolecular targets: The present application relates to methods, compositions and systems for the specific, controllable degradation of targeted proteins. Typically, the target proteins have a function which has not yet been elucidated. The disclosure enables one to study the effect of degrading a targeted protein, which in turn, will lead to a... Agent:
20120214169 - Differential levels of haptoglodin isoforms in small cell lung cancer: The invention is directed to protein or nucleic acid assays for diagnosis, prognosis and monitoring of lung cancers, in particular small cell lung cancer using biomarkers comprising haptoglobin isoforms, or fragments or variants thereof.... Agent: Boston Medical Center Corporation
20120214168 - Microfluidic device-based nucleic acid purification method: A method is provided for purifying nucleic acid from a sample in a microfluidic device. The method can be used to purify nucleic acids from any source known in the art that comprises nucleic acids, such as prokaryotic or eukaryotic organisms, viruses, cell, tissues, organs, etc. In a specific example,... Agent: Rheonix, Inc.
20120214171 - Rotation-dependent transcriptional sequencing systems and methods of using: Provided herein are rotation-dependent transcriptional sequencing methods and systems.... Agent:
20120214172 - Graphene-based field-effect transistor biosensors: The disclosure provides a field-effect transistor (FET)-based biosensor and uses thereof. In particular, to FET-based biosensors using thermally reduced graphene-based sheets as a conducting channel decorated with nanoparticle-biomolecule conjugates. The present disclosure also relates to FET-based biosensors using metal nitride/graphene hybrid sheets. The disclosure provides a method for detecting a... Agent: Uwm Research Foundation, Inc.
20120214174 - Gene and polypeptide relating to breast cancer: Herein disclosed are methods of identifying substances suitable for the treatment and prevention of cancer, particularly cancers associated with the overexpression of GALNT6 gene. Methods of the present invention use or target the binding between GALNT6 protein and MUC1 protein, and the glycosylation of MUC1 protein by GALNT6 protein as... Agent: Oncotherapy Science, Inc.
20120214176 - Detection of specific antigens in a population of antigens: r
20120214175 - Separation, washing and determination of analytes tagged with magnetic particles: Method for detecting a material of interest, usually an antibody or an antigen on a red blood cell, in a liquid, by observing the potential antigen/antibody reaction products in a novel way. Reaction products are deposited on a magnetic substrate and will exhibit different properties depending upon whether or not... Agent:
20120214173 - Methods of identifying modulators of an ehd polypeptide: The invention relates to a method of identifying a modulator of an EHD family polypeptide, said method comprising (i) providing a first and second sample of an EHD polypeptide; (ii) contacting said first sample with a candidate modulator; (iii) contacting said first and second samples with ATP; and (iv) monitoring... Agent:
20120214181 - Assay for pcsk9 inhibitors: The present invention provides methods for identifying modulators of PCSK9, for example, using a variety of assay formats. Inhibitors of PCSK9 can be used for example, to treat diseases such as hyperlipidemia and related disorders.... Agent:
20120214178 - Mesenchymal stem cells expressing tnf-alpha receptors: Mesenchymal stern cells which express TNF-α receptor Type I in an amount of at least 13 pg/106 cells. Such mesenchymal stem cells inhibit the proliferation of lymphocytes and may be employed, in particular, in the treatment of graft-versus-host disease.... Agent:
20120214177 - Methods and compositions for diagnosis of urosepsis and urinary tract infection: Methods for diagnosis of and distinguishing between, urosepsis, sepsis, and urinary tract infections (UTIs) are disclosed The diagnostic methods are based on determining the level of NGAL protein in a bodily fluid sample, such as urine sample.... Agent: The Trustees Of Columbia University In The City Of New York
20120214179 - Methods for detecting pre-diabetes and diabetes using differential protein glycosylation: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include... Agent: Diabetomics, LLC
20120214183 - Methods for evaluating risk of mother's milk or food inducing an onset of atopic dermatitis, and mother's milk or food with reduced risk of inducing an onset of atopic dermatitis: An entity of a Th2 adjuvant activity in mother's milk has been revealed as coenzyme A by HPLC and mass spectrometry. The followings have been found out that: a risk of developing atopic dermatitis can be evaluated by targeting coenzyme A; and any one of a food and mother's milk... Agent: Immno, Inc.
20120214180 - Nt-pro anp and sflt-1 for the differentiation between circulatory and ischemic events: The present disclosure relates to the field of laboratory diagnostics. The present disclosure provides means and methods for differentiating between an acute circulatory event and an ischemic event, as the cause underlying an acute medical event of a patient.... Agent: Roche Diagnostics Operations, Inc.
20120214182 - System for determining unprocessed and partially processed neurotoxin type a: The present invention is concerned with tools for the quality control and safety during manufacture of neurotoxins. In particular, it relates to a method for the determination of the amount of partially processed and/or unprocessed Botulinum neurotoxin A polypeptide (BoNT/A) in a solution comprising processed and partially processed and/or unprocessed... Agent: Merz Pharma Gmbh & Co. Kgaa
20120214184 - Doxorubicin immunoassay: Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are useful in immunoassays for the quantification and monitoring of doxorubicin in biological fluids.... Agent:
20120214185 - Method of screening mhc molecules: The invention relates to a method for screening the binding properties of constituent peptides of MHC molecules by providing in solution MHC molecules or their constituent peptides for a set of MHC molecules including a plurality of subsets of MHC molecules, wherein the MHC molecules of each subset differ from... Agent: Proimmune Limited
20120214186 - Methods and compositions for detecting and quantifying sappbeta: The present invention provides methods (assays) for detecting and/or quantifying sAPPβ, a secreted β-secretase (BACE1) cleavage fragment of the β-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPPβ and... Agent:
20120214187 - Method for enhancing the sensitivity of antibody based assays: There is a constant need for increased sensitivity of antibody-based assays as well as a need for high affinity antibodies. Higher affinity molecules such as antibodies increase the specificity and sensitivity of assays. Both increased sensitivity and higher affinity can be achieved when multiple copies of a binding molecule are... Agent: Ffina Biolutions, LLC
20120214189 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent:
20120214188 - Light-activated ion channel molecules and uses thereof: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the use of light-activated ion channels (LAICs).... Agent:
20120214193 - Method for measurement of fluorescence intensity of voltage-sensitive fluorescent dye: The present inventors screened a variety of substances and found that vitamin E has an action for increasing the sensitivity of potential-sensitive fluorochromes whereas cholesterol has an action for enhancing the fluorescent intensity of potential-sensitive fluorochromes. In addition, it has become clear that these substances can be combined in such... Agent: Keio University
20120214192 - Method for producing antigen-specific b cell population: The present invention provides a method for producing an antigen-specific B cell population comprising IgG-positive B cells specific to a specific antigen, the method comprising: culturing IgG-positive B cells together with the specific antigen in the presence of IL-21, while conferring stimulation to the IgG-positive B cells via CD40, a... Agent: Tokyo University Of Science Educational Foundation Administrative Organization
20120214191 - Methods and systems for efficient processing of biological samples: Systems and methods of sample (1) and staining processing including compression and dynamic movement of liquids (3) in a fluidically moving substantially contained liquid bridge (6) perhaps between a hydrophobic wand (4) and a hydrophilic sample support element (2). Embodiments may include low volume reagent and perhaps even low volume... Agent: Biocare Medical, LLC
20120214190 - System and method based on blood components for estimating human physiological parameters: A system and method based on blood components for estimating human general physiological parameters comprises determining the predetermined value of general physiological parameters indicative of illness and disease to monitor health status at different time points on the basis of basic physiological parameters indicated as the percentage of a particular... Agent:
20120214194 - Process for synthesizing epicconone analogs: s
20120214195 - Method for tissue sample fixation: An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period... Agent:
20120214196 - Polypeptides having glucoamylase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s
20120214197 - Polypeptides having glucoamylase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s
20120214198 - Algaculture method: The present invention relates to bioprocess engineering methods in which aqueous phases of anaerobic biologically treated organic suspensions are supplied to algal cultures as media components. The present invention also relates to the use of aqueous phases of anaerobic biologically treated organic suspensions as media components of algal cultures. Additionally,... Agent: Fraunhofer-gesellschaft Zur Forderung Der Angewandten Forschung E.v.
20120214199 - Lis-pro proinsulin compositions and methods of producing lis-pro insulin analogs therefrom: Lis-Pro modified proinsulin sequences that have a modified C-peptide amino acid and/or nucleic acid modification are presented. Methods for producing Lis-Pro insulin analogs are also disclosed. Highly efficient processes for preparing the Lis-Pro insulin analogs and improved preparations containing the Lis-Pro insulin analogs prepared according to the methods described herein... Agent: Elona Biotechnologies
20120214201 - Probe incorporation mediated by enzymes: The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs recognized by lipoic acid ligase and lipoic acid ligase mutants.... Agent: Massachusetts Institute Of Technology
20120214200 - Prokaryotic expression construct: A pro-polypeptide which is useful for the expression of a polypeptide of interest in a prokaryotic cell. Therefore the pro-polypeptide is fused to the N-terminus of the polypeptide of interest. The pro-polypeptide as reported herein provides for improved expression yields and improves the handling of the fusion polypeptide (downstream processing,... Agent:
20120214203 - Methods for improving recombinant protein expression: Materials and methods are provided which allowed for increased expression of a transfected gene of interest in a recombinant host cell.... Agent: Cmc Icos Biologics ,inc.
20120214202 - Recombinant host cells having an increase in buoyant density: Methods are provided to obtain recombinant microbial cells having at least one genetic modification that increase the buoyant density of a recombinant microbial cell or the buoyant density of inclusion bodies produced within a recombinant microbial cell. Exemplified are genetic modifications that increase the buoyant density of a recombinant microbial... Agent: E. I. Du Pont De Nemours And Company
20120214204 - Cell culture media for uvc exposure and methods related thereto: The invention relates to cell culture media optimized for exposure to ultraviolet C (UVC) light exposure and related methods.... Agent: Amgen Inc.
20120214205 - Plant biomass pretreatment method: A plant biomass pretreatment method which allows prompt pretreatment of plant biomass with simple equipment is provided. The method includes continuously performing in sequence, inside an extruder, pretreatment steps of coarsely crushing the plant biomass to a predefined size or smaller, adding a decomposing agent(s) to the coarsely crushed plant... Agent: Toyota Jidosha Kabushiki Kaisha
20120214206 - Vectors for molecule delivery to cd11b expressing cells: The invention relates to a novel use of a Bordetella adenylcyclase toxin in the manufacturing of vectors for targeting in vivo a molecule of interest, specifically to CD11b expressing cells. The invention also relates to an immunogenic composition that primes immune responses, to pharmaceutical compositions and to a new vector... Agent: Institut Pasteur And Centre De La Recherche Scientifique
20120214207 - Methods and systems for fast pcr heating: A microplate for polymerase chain reaction (PCR) comprises a substrate having a metallic material for heating PCR samples, and a barrier layer disposed adjacent to the substrate. In some cases, the barrier layer is formed of a first polymeric material. The microplate includes one or more wells for containing PCR... Agent:
20120214208 - Fusion polypeptides and uses thereof: The invention relates to fusion polypeptides comprising a polynucleotide-binding domain, such as a DNA-binding domain, and a ligase domain, such as a DNA ligase domain, methods for the production of such fusion polypeptides, and uses of the fusion polypeptides, for example in a range of molecular biological techniques as well... Agent: Massey University
20120214209 - Methods for producing end-products from carbon substrates: The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction... Agent: Danisco US Inc.
20120214211 - Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the sugr gene is present in attenuated form: The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation... Agent: Evonik Degussa Gmbh
20120214212 - Expression and application of recombinant faees in algae as a novel method to produce biodiesel in vivo: This discovery is related to the production of bioenergy fuels in vivo, specifically related to the production of biodiesel fuels using algae. We express FAEES (fatty acid ethyl ester synthase) in algae, and use the recombinant FAEES (fatty acid ethyl ester synthase) in the algae to synthesize biodiesel, fatty acid... Agent:
20120214213 - Recombinant hosts and methods for manufacturing polyhydroxyalkanoate: Known attempts using engineered bacteria to produce P(3HB-co-4HB) with carbon sources that are structurally unrelated to 4-hydroxybutyrate resulted in relatively low 4HB monomer content of 1.5 to 5 mol %. The current invention provides recombinant hosts for producing P(3HB-co-4HB) wherein the plasmid including succinate semialdehyde dehydrogenase gene (sucD gene) and... Agent: Tianjin Greenbio Material Co., Ltd.
20120214214 - Transformant and process for production thereof, and process for production of lactic acid: The present invention relates to a transformant, containing a lactate dehydrogenase gene which is introduced into Schizosaccharomyces pombe as a host, in which a part of a gene cluster encoding a pyruvate decarboxylase in the Schizosaccharomyces pombe host is deleted or inactivated.... Agent: Asahi Glass Company, Limited
20120214215 - Packed bed scrubber using a fusel oil solvent: A two stage scrubber process has a first stage removing the hazardous air pollutants and recovering the majority of the ethanol. A second stage uses water as the scrubbing solvent to recover any residual ethanol that is stripped from the first stage.... Agent: Pinnacle Engineering, Inc.
20120214216 - Biomass pretreatment process: A process is described for pretreating lignocellulosic biomass. The process comprises swelling the lignocellulosic biomass with an aqueous liquid. The pretreated lignocellulosic biomass may be used as a feedstock for the enzymatic conversion to ethanol, or in a thermal conversion. process to produce bio-oil. The pretreatment results in a greater... Agent: Kior, Inc.
20120214217 - In situ tissue engineering using magnetically guided three dimensional cell patterning: Methods are provided for the three dimensional manipulation of cells, and for the formation of an organized engineered cell tissue. Also provided are the organized engineered cell tissues produced by the methods. In one method, a plurality of magnetically labeled cells are mixed with a cross-linkable hydrogel to form a... Agent:
20120214218 - Transfection with magnetic nanoparticles and ultrasound: The invention includes a magnetic nanoparticle molecular delivery vehicle to be used for transfection and delivery of therapeutic molecules across cell membranes and to specific sites in the body, using magnetic forces and ultrasound.... Agent: Intelligentnano Inc.
20120214219 - Separation of a target substance from a fluid or mixture using encapsulated sorbents: Method and apparatus for separating a target substance from a fluid or mixture. Capsules having a coating and stripping solvents encapsulated in the capsules are provided. The coating is permeable to the target substance. The capsules having a coating and stripping solvents encapsulated in the capsules are exposed to the... Agent:
20120214220 - Xylanase composition and method for manufacturing the same: A xylanase composition and a method for manufacturing the xylanase composition are provided, wherein the xylanase composition comprises a xylanase and a stabilizer, and the xylanase is from an anaerobic fungus, the stabilizer comprises a polyol, and the content of the polyol is at least 40 wt %, based on... Agent:
20120214221 - Methods for monitoring multiple gene expression: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media... Agent: Novozymes A/s
20120214222 - Method for manufacturing a device for regenerating biological tissues, particularly for regenerating tissues of the central nervous system: A method for manufacturing a device for regenerating biological tissues, particularly for regenerating tissues of the central nervous system, and a device that can be manufactured with said method, the device comprising an outer sheath based on collagen which is substantially tubular and can be interposed between the endings of... Agent:
20120214223 - Worm culture systems: Devices and methods are disclosed for the containment and culture of worms, and the preparation of composts, vermicomposts, and castings from organic and inorganic wastes.... Agent:
20120214224 - Flow based clinical analysis: Values of clinical properties are normally measured by taking a sample from a patient, mixing an aliquot with a reagent, placing the mixture into a selected instrument, and measuring a property. If another property is required, another measurement sequence must be created. This can be efficient on a large scale,... Agent:
20120214225 - Cell incubator and incubation condition monitoring system: A cell incubator includes: a culture cell accommodating section which accommodates cells to be cultured and a culture solution; and an RFID tag which is attached to the culture cell accommodating section and which is configured to transmit predetermined information to a communicating apparatus in response to reception of a... Agent: Nihon Kohden Corporation
20120214226 - Insert for cell cultures: An insert for cell cultures has a hollow housing (1) of a cylinder-like shape, with an upper, in particular circular, opening (2) and a membrane-like base located opposite the opening (2). On the peripheral opening edge (6) outward protruding support arms (5) are spaced apart from one another. The housing... Agent: Sabeu Kunststoffwerk Northeim Gmbh
20120214227 - Apparatus for preparing cytological specimens: A handheld apparatus for preparing a specimen slide includes a handle, a filter holder assembly coupled to and extending from the handle; and a slide holder assembly coupled to and extending from the handle spaced apart from the filter holder assembly, wherein the slide holder assembly comprises a plurality of... Agent: Hologic, Inc.
20120214228 - Tal effector-mediated dna modification: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.... Agent:
20120214230 - Cell culture/handling product and method for production and use thereof: The present invention relates to a fast a simple coating procedure for coating of cell culture and/or handling surfaces to prevent cell adhesion and growth. The invention relates to a cell culture/handling product coated with phenyl dextran, as well as methods of producing and using it.... Agent: Ge Healthcare Bio-sciences Ab
20120214229 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.
20120214231 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan,inc.
20120214232 - Methods of culturing cells in a medium comprising transforming growth factor beta 1 and basic fibroblast growth factor: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.... Agent: Technion Research & Development Foundation Ltd.
20120214233 - Cystatin c as an antagonist of tgf-beta and methods related thereto: Disclosed are Cystatin C (CysC) homologues, including CystC homologues that act as antagonists or inhibitors of transforming growth factor-β (TGF-β). Also disclosed are methods to identify CystC homologues that are antagonists or inhibitors of TGF-β and compositions and therapeutic methods using CystC and homologues thereof to regulate the activity of... Agent: National Jewish Health
20120214234 - Ips cells and method for preparing the same: The present invention provides a method for producing iPS cells, comprising reacting cells with at least one connexin inhibitor and at least one TGFβ signaling inhibitor; iPS cells comprising at least one connexin inhibitor; an iPS cell inducer comprising at least one inhibitor selected from the group consisting of connexin... Agent: Kyoto Prefectural Public University Corporation
20120214235 - Methods and compositions for treating neurodegenerative disorders and alzheimer's disease and improving normal memory: The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and progression of Alzheimer's disease.... Agent: The Regents Of The University Of California
20120214236 - Generating induced pluripotent stem cells and progenitor cells from fibroblasts: The present disclosure provides a method of generating progenitor cells, such as hematopoietic or neural progenitor cells, from fibroblasts, such as dermal fibroblasts, comprising providing fibroblasts that express or are treated with a POU domain containing gene or protein and culturing the cells under conditions that allow production of progenitor... Agent: Mcmaster University
20120214237 - Compositions and methods useful for culturing differentiable cells: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.... Agent: Viacyte, Inc.
20120214238 - Microbubble devices, methods and systems: A hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator to apply dynamic deformational loading to a hydrogel is disclosed. Also disclosed are methods for producing hydrogels with microbubbles and for culturing cells using hydrogels with microbubbles.... Agent: The Trustees Of Columbia University In The City Of New York
20120214239 - Plant biochemical systems and uses thereof: Plants and plant cells including an isolated nucleic acid encoding for prephenate dehydratase, wherein the nucleic acid is operably linked to a promoter such that prephenate dehydratase is expressed at sufficient levels to protect the plant cell from damage from an abiotic or biotic stressor. The abiotic or biotic stressor... Agent: The Board Of Trustees Of The University Of Illinois
20120214240 - Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same: A reprogramming gene-loaded Sendai viral vector comprising Sendai virus genes and reprogramming genes, wherein the Sendai virus genes include an NP gene, P/C gene, M gene, F gene, HN gene and L gene, wherein each of the M gene, the F gene and the FIN gene is from a Sendai... Agent: National Institute Of Advanced Industrial Science And Technology
20120214242 - Cre-lox based gene knockdown constructs and methods of use thereof: The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo.... Agent: Massachusetts Institute Of Technology
20120214241 - Zinc finger nuclease modification of leucine rich repeat kinase 2 (lrrk2) mutant fibroblasts and ipscs: Disclosed herein are methods and compositions for alteration of an LRRK2 gene in a fibroblast or iPSC.... Agent:
20120214243 - Method of efficiently establishing induced pluripotent stem cells: Provided are a method of improving iPS cell establishment efficiency, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B to a somatic cell, particularly to a somatic cell on which Lin28 is ineffective or less effective than Lin28B in improving iPS cell establishment efficiency, and a... Agent: Kyoto University08/16/2012 > 110 patent applications in 62 patent subcategories.
20120208172 - Methods of increasing liver proliferation: The present invention is directed to methods of enhancing liver repair after injury, resection or transplantation using antagonists of the bone morphogenetic protein (BMP) signaling pathway in the liver.... Agent: Beth Israel Deaconess Medical Center, Inc.
20120208173 - Terpene synthases from santalum: An isolated nucleic acid molecule that encodes a terpene synthase and is selected from among: a) a nucleic acid molecule comprising the sequence of nucleotides set forth in SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 5; b) a nucleic acid molecule that is a fragment... Agent:
20120208177 - Assay methods for mdv-1: A method for the quantification of a vaccine strain and/or a virulent strain of Wlarek's Disease Virus Serotype-1 (MDV-1) in a sample from a bird, comprising the steps of: (i) providing a biological sample from the bird and optionally isolating nucleic acid from the biological sample; (ii) subjecting the biological... Agent:
20120208179 - Compositions for use in identification of orthopoxviruses: Oligonucleotide primers and compositions and kits containing the same for rapid identification of orthopoxviruses by amplification of a segment of viral nucleic acid followed by molecular mass analysis are provided.... Agent: Ibis Biosciences, Inc.
20120208175 - Detection of hiv-related proteins in urine: A method for detecting HIV infection in a mammal is disclosed. The method contains the steps of isolating exosomes from a urine sample of a mammal and detecting the presence of HIV-specific biomarker in said isolated exosomes. A method for diagnosing a mammal with an HIV-associated disease, in particular, HIV-associated... Agent: Morehouse School Of Medicine
20120208180 - Method for early diagnosis of carcinomas of the anogenital tract: A method for the early diagnosis of carcinomas of the anogenital tract, preferably of the cervical carcinoma, and the preliminary stages thereof is described. The method is based on the determination of the methylation status of segments of the gene regions of ASTN1 (astrotactin 1) and ZNF671 (zinc finger protein... Agent:
20120208176 - Multivalent epitope in complex with a detection marker for the early serodiagnosis of infections: The present invention relates to a new method to determine the presence of antibodies to a pathogen in a serological sample using a new detection reagent which comprises at least two and preferably at least four copies of an antigen from the pathogen and a detectable marker. The present invention... Agent: Institut Pasteur
20120208174 - Plasmonic system for detecting binding of biological molecules: Detection and characterization of molecular interactions on membrane surfaces is important to biological and pharmacological research. In one embodiment, silver nanocubes interfaced with glass-supported model membranes form a label-free sensor that measures protein binding to the membrane. The present device and technique utilizes plasmon resonance scattering of nanoparticles, which are... Agent: The Regents Of The University Of California
20120208178 - Probes comprising fluorescent artificial nucleobases and use thereof for detection of single base alteration: The present invention relates to forced intercalation probes (FIT-probes) comprising at least one nucleoside analogue which comprises at least a fluorescent artificial nucleobase directly bound to a carbon of a modified sugar moiety wherein said modified sugar moiety is a carba-sugar or an amino acid nucleic acid (AANA). Thereby the... Agent:
20120208181 - Biosynthesis of human milk oligosaccharides in engineered bacteria: The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.... Agent: Glycosyn LLC
20120208193 - Detecting methylation in a subpopulation of genomic dna: This invention provides methods of determining the biological, pathological, genetic, epigenetic or disease status in a biological sample by determining the methylation status of a subpopulation of genomic DNA in the sample.... Agent: Bio-rad Laboratories, Inc.
20120208188 - Diagnostic and treatment for chronic and acute phase myeloid leukemia: Disclosed are methods of predicting responsiveness of a cancer cell to a tyrosine kinase inhibitor, and methods of predicting the risk of progression of a cancer cell to a more aggressive form. Also provided are methods of reducing proliferation or promoting differentiation of a cancer cell having reduced level of... Agent:
20120208195 - Disease susceptibility: Provided herein is a method of assessing the susceptibility of a subject to, or aiding the diagnosis of, an anxiety disorder or depression, the method including determining whether the subject has a haplotype including rs3216799, rs6814934, rs7658048, rs2070950 and rs2070951 with respective alleles ‘+CT, ‘C’, ‘T’, ‘C’ and ‘C’. Also... Agent: Universiteit Leiden
20120208182 - Genetic test for liver copper accumulation in dogs and low copper pet diet: The present invention provides a method of determining the susceptibility of a dog to liver copper accumulation, comprising detecting the presence or absence in the genome of the dog of (a) a polymorphism in the GOLGA5, ATP7a or UBL5 gene that is indicative of susceptibility to liver copper accumulation and/or... Agent:
20120208190 - Luminescent metal ion complexes: The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion chelating component covalently bound to a carrier molecule. Also provided are methods of making and using the luminescent metal... Agent: Biosearch Technologies, Inc.
20120208187 - Method and kit for determining severity and progression of periodontal disease: An improved method and kit of determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising the steps of (i) taking a biological sample from said patient; (ii) genotyping said biological sample for genetic polymorphism pattern comprising IL 1B... Agent:
20120208185 - Method for determining the risk of developing a neurological disease: Methods and kits are provided for determining whether a subject is at risk of developing a neurological disease such as Alzheimer's disease and multiple sclerosis. The methods and kits are based on the detection of one or more nucleic acid variants in the MBL gene of the subject.... Agent: Abbott Healthcare Products B.v.
20120208183 - Methods for determination of haplotype dissection: A method for molecular haplotyping of a subject is disclosed. The method comprises: randomly selecting a set of chromosomes in each of a plurality of lyzed diploid cells of the subject, collecting the selected chromosomes from said plurality of cells into a plurality of sample tubes, wherein each sample tube... Agent: Morehouse School Of Medicine
20120208189 - Methods for isolation, identification, and quantification of mirnas: Method and compositions and kits for isolation, identification, and quantification of miRNAs and other small RNAs, including but not limited to, siRNAs, mRNAs, and snRNAs are disclosed. Methods of diagnosing a disease or its progression are also disclosed.... Agent: Life Technologies Corporation
20120208186 - Methods for the diagnosis of fetal abnormalities: The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a... Agent:
20120208192 - Nucleic acid amplification employing temperature oscillation: A method for carrying out an isothermal nucleic acid amplification reaction at a predetermined temperature, said method comprising changing the temperature of the reaction mixture away from the said predetermined temperature and allowing it to return to the predetermined temperature at least once during the amplification reaction so as to... Agent: Enigma Diagnostics Limited
20120208194 - Preparation of templates for nucleic acid sequencing: m
20120208191 - Staphylococcus detection assays: Provided herein are methods, kits, and compositions related to nucleic acid detection that allow the detection and discrimination of various Staphylococcus species and types. In particular, provided herein are assays that allow the detection of MSSA, MSSE, MRSA, MRSE, VRSA, VRSE, and MRSA community strain by detecting the presence of... Agent: Brandeis University
20120208184 - Systems and methods for imaging and processing tissue: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest... Agent:
20120208200 - Association of edg5 polymorphism v286a with type ii diabetes mellitus and venous thrombosis/pulmonary embolism and the use thereof: The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological... Agent: Sanofi-aventis Deutschland Gmbh
20120208197 - Monitoring gene silencing and annotating gene function in living cells: The cell-based assays described in the present invention can be used to directly assess the sensitivity and specificity of the gene annotation reagent against its target, mapping genes and to determine if a non-targeted gene participates in a pathway of interest or is functionally linked to another gene or protein.... Agent: Odyssey Thera, Inc.
20120208198 - Novel gene encoding myb transcription factor involved in proanthocyanidin synthesis: An isolated or recombinant MYB polypeptide having activity as a transcription factor in the synthesis of proanthocyanidins in plants, and nucleic acid molecule encoding same, wherein the polypeptide activates in the plants (a) promoters of the leucoanthocyanidin (LAR) and anthocyanidid reductase (ANR) genes, and (b) promoters of at least two... Agent: Commonwealth Scientific And Industrial Research Organization
20120208199 - Random-primed transcriptase in-vitro transcription method for rna amplification: A random-primed reverse transcriptase-in vitro transcription method of linearly amplifying RNA is provided. According to the methods of the invention, source RNA (or other single-stranded nucleic acid), preferably, mRNA, is converted to double-stranded cDNA using two random primers, one of which comprises a RNA polymerase promoter sequence (“promoter-primer”), to yield... Agent: Life Technologies Corporation
20120208201 - Enhanced gene expression in algae: The invention provides a system of enhancing the expression of transgenes in algae. Transgenes are engineered to have a binding site for certain proteins in proximity to their promoter, for example a LexA binding site. The algae is also engineered to express a nucleosome alteration protein fused to a protein... Agent:
20120208204 - Compositions and methods for inhibiting tumor growth: The invention provides methods and compositions for inhibiting p53-inactivated cancers. Cancer cells are preferentially inhibited compared to normal cells by inhibiting tumor survival kinases that are required for growth of tumor cells but not normal cells.... Agent: Peresident And Fellows Of Harvard College
20120208203 - Compositions and methods for modulating c-rel-dependent cytokine production: The present invention is directed to compositions and methods for modulating c-Rel-dependent cytokine production without materially altering the level of expression of NFκB and/or the amount of IκB. The present invention is also directed to screening for modulators of c-Rel activity as determined by assaying for altered subcellular localization of... Agent: Synta Pharmaceuticals Corp.
20120208206 - Method for producing mast cells from pluripotent stem cells: The present invention relates to a method for producing human mast cells from human pluripotent stem cells. More particularly, the present invention provides a method for producing human mast cells from human pluripotent stem cells, comprising the steps of: (a) culturing human pluripotent stem cells under a condition suitable for... Agent:
20120208202 - Method for the reduction of biological sampling errors by means of image processing: The present invention relates to methods and devices for reducing biological sampling errors by means of image processing. Image processing techniques are used to determine the volume of sample added to a device, such as a diagnostic test, and to correct for user error in sampling techniques.... Agent: Alere Scarborough, Inc.
20120208205 - Point-of-care test system and method for applying a sample: The present invention relates to a test system or assay system (detection system) and to a test method, preferably in use in the point-of-care (PoC) field.... Agent: Dst Diagnostische Systeme & Technologien Gmbh
20120208207 - Sample processing device: A floating chamber set may include a plurality of containers coupled to a frame such that each container translates vertically within a limited vertical range independent of the other containers. Each container may be perforated to allow liquid penetration.... Agent: The Johns Hopkins University
20120208211 - Humanised psoriasis model: The present invention relates to a new humanised animal model of psoriasis. Said model is generated by grafting humanised skin equivalents in the animal, injecting T lymphocytes and cytokines involved in the generation of the disease in humans, and performing the tape-stripping technique in order to generate damage in said... Agent: Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas (ciemat)
20120208210 - Post-translational modifications indentified by elemental analysis: Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate analysis of post-translation modifications of substrates by enzymes involved in post-translational modifications, including kinase and phosphatase enyzmes... Agent: Dvs Sciences Inc.
20120208208 - Pcsk9 immunoassay: Methods of using PCSK9 antagonists. More specifically, methods for measuring circulating PCSK9 levels in a biological sample by means of an immunoassay.... Agent:
20120208209 - Pcsk9 immunoassay: Methods of using PCSK9 antagonists. More specifically, methods for measuring circulating PCSK9 levels in a biological sample by means of an immunoassay.... Agent:
20120208215 - Biomarkers for pre-diabetes, cardiovascular diseases, and other metabolic-syndrome related disorders and methods using the same: Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are... Agent: Metabolon, Inc.
20120208213 - Detection of synthetic cannabinoids: The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the JWH and CP families. Unique antibodies derived from novel immunogens enable said methods and kits.... Agent: Randox Laboratories Limited
20120208212 - Methods of assessing crohn's disease patient phenotype by i2, ompc and asca serologic response: The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a... Agent: Cedars-sinai Medical Center
20120208216 - Non-cross-reactive anti igg antibodies: Herein are reported the cell lines DSM ACC3006, DSM ACC3007, and DSM ACC3008, as well as the antibodies obtained from the cell lines and the use of an antibody obtained from the cell lines in an immunoassay. Also are reported antibodies binding to human or chimpanzee IgG and not binding... Agent:
20120208214 - Rapid saccharide biomarker assay: The present invention includes compositions, methods, kits and diagnostics for biosugar profiling of biological samples from a patient suspected of having a disease associated with changes in the biosugar profile. The biosugar profile from the patient sample is compared to a healthy biosugar profile from the same type of biological... Agent: Mannatech, Incorporated
20120208217 - Methods for detecting pre-diabetes and diabetes using differential protein glycosylation: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include... Agent: Diabetomics, LLC
20120208218 - Methods for detecting pre-diabetes and diabetes using differential protein glycosylation: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include... Agent: Diabetomics, LLC
20120208219 - Method for assaying cholesterol in apoe-containing hdl: This invention provides a method for separately or simultaneously quantifying cholesterol in a total amount of HDL-C, cholesterol in an HDL subfraction of apoE-containing HDL-C, and cholesterol in an HDL subfraction of apoE-deficient HDL-C. The method comprises enzymatically and separately quantifying cholesterol in apoE-containing HDL and cholesterol in apoE-deficient HDL... Agent: Denka Seiken Co., Ltd.
20120208220 - Method and kit for detecting foltate: A method and a kit for detecting folate are disclosed. The method includes the following steps: (a) mixing a sample and an extraction buffer to form a mixture, heating and then cooling the mixture, and separating a supernatant from the mixture by centrifugation; (b) adding a recombinant γ-glutamyl hydrolase (GGH)... Agent: National Cheng Kung University
20120208221 - Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof: This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with,... Agent: Biomarin Pharmaceutical Inc.
20120208222 - Microchemical reactor: Microchemical reactors embedded in absorbant materials are described that allow operators to perform chemical reactions and chemical cascades using multiple microencapsulated reagents, which release stoichiometric amounts of reagents in a predetermined time sequence with a predetermined logic.... Agent:
20120208223 - Fluorescence resonance energy transfer enzyme substrates: Disclosed are compounds of formula (I) wherein D1 is a first dye moiety whose fluorescence properties may be modulated so as to be suitable as a donor or an acceptor in an energy transfer arrangement; D2 is a second dye moiety suitable as an acceptor or a donor in an... Agent: Ge Healthcare As
20120208224 - Novel method for quantifying proteins by mass spectrometry: The present invention relates to a method for the quantitative detection of a target protein in a sample, in which the second-generation fragment ions are detected for providing a series of quantitative measurements, at least one of which is correlated to the amount of proteotypic peptide generated and to the... Agent: Universite Claude Bernard Lyon I
20120208225 - Modified peptide substrate: The invention provides novel reagents and methodologies for detecting free versus bound enzyme. It is particularly useful to detect thrombin when it is not bound to A2M in the presence of thrombin bound to A2M by using a modified substrate that is sterically hindered from reacting with the bound thrombin.... Agent: Mcmaster University
20120208226 - Fructosyl amino acid oxidase: In one form, a mutant fructosyl amino acid oxidase modified at an amino acid residue involved in a proton relay system is provided. The mutant fructosyl amino acid oxidase has reduced oxidase activity while substantially maintaining its dehydrogenase activity. Other forms include an assay device and assay method for measuring... Agent:
20120208227 - Apparatus and method for processing cell culture data: One embodiment of the invention provides a method of processing cell culture data. The data comprises results from a large number of samples, the results being obtained by performing multiple stages of cell culture in succession on each sample. Each stage represents a cell culture treatment having a particular set... Agent: Plasticell Limited
20120208229 - Device for examining cells having an elastomer, and use of the device: A device for examining cells comprising an elastomer and the use thereof. The elastomer comprises a bottom and a thicker edge region; and the bottom is provided with regular microstructures. Such elastomers are suitable for stretch experiments, notably of the uniaxial type.... Agent:
20120208228 - Pipelining assembly for a blood analyzing instrument: A pipelining assembly for use in a blood analyzing instrument, methods for performing parallel pipelining functions, and methods for processing a plurality of prepared blood samples through a blood analyzing instrument. The pipelining assembly presented generally includes a first sample preparation chamber, a first queuing chamber in fluid communication with... Agent:
20120208230 - Em-lacquer water solution mixed with natural component, method for preparing fermented anti-oxidant material using the same, and method for processing the material: The present invention relates to an EM-lacquer water solution mixed with a natural component, a method for preparing a fermented anti-oxidant material using the same, and a method for processing the material. Particularly, the EM-lacquer water solution mixed with a natural component is prepared by mixing an EM-lacquer solution, which... Agent:
20120208231 - Metabolic engineering of arabinose-fermenting yeast cells: The invention relates to an eukaryotic cell expressing nucleotide sequences encoding the ara A, ara B and ara D enzymes whereby the expression of these nucleotide sequences confers on the cell the ability to use L-arabinose and/or convert L-arabinose into L-ribulose, and/or xylulose 5-phosphate and/or into a desired fermentation product... Agent: DsmIPAssets B.v.
20120208232 - Cell-free synthesis of active reprogramming transcription factors: Compositions and methods are provided for the cell-free synthesis of active reprogramming factor polypeptides. The reprogramming factors may be synthesized as fusion proteins comprising a permeant domain, such as polyarginme. The cell free-synthesis may be conducted at about 25 C in a bacterial cell extract from genetically alterd cells having... Agent:
20120208235 - Endoglucanase variants: The present invention relates to variant endoglucanases having improved thermoactivity, improved thermostability, and improved viscosity reduction activity over wild-type M. thermophila endoglucanase.... Agent: Codexis, Inc.
20120208233 - Enhancement of protein production in eukaryotic cells: An embodiment relates to the increased expression of polypeptides in eukaryotic cells. A method for increased production is described using an expression vector comprising a polynucleotide encoding a desired polypeptide and a G quartet like motif sequence.... Agent: Texas Department Of Transportation
20120208236 - Methods for detecting modulators of cytokine receptor zalpha11: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can... Agent: Zymogenetics, Inc.
20120208234 - Protein having affinity for immunoglobulin, and immunoglobulin-binding affinity ligand: An object of the present invention is to create a novel engineered Protein A ligand having better antibody dissociation properties in the presence of an acid than conventional engineered Protein A ligands and a further object of the present invention is to create a novel engineered Protein A ligand having... Agent: Kaneka Corporation
20120208238 - Engineered immunoglobulin fc polypeptides: Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example,... Agent:
20120208237 - Human anti-kir antibodies: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9... Agent: Novo-nordisk A/s - Novo Alle
20120208239 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecualr Systems, Inc.
20120208240 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecurlar Systems, Inc.
20120208241 - Thermocycling device for nucleic acid amplification and methods of use: The present invention provides thermocycling devices useful for amplification of nucleic acids in droplets. The thermocycling device utilizes the flow of one or more fluids through a main compartment at temperatures sufficient to conduct a polymerase chain reaction. Methods of amplifying nucleic acids in droplets are also provided.... Agent: Raindance Technologies, Inc.
20120208242 - Method and rna reactor for exponential amplification of rna: The present invention relates to a method for exponential amplification of RNA using a primer independent RNA-dependent RNA polymerase (RdRp) wherein reactants are premixed cycle and then transferred into the reaction chamber in which the steps of polymerisation of the complementary strand and separation of the resulting double-stranded RNA occur.... Agent: Riboxx Gmbh
20120208243 - Glucoamylase variants: The invention relates to a variant of a parent fungal glucoamylase, which exhibits altered properties, in particular improved thermal stability and/or increased specific activity.... Agent: Novozymes A/s
20120208244 - Method for producing monatin: [Means for solving the Problem] A method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin or a salt thereof, comprising isomerizing the 2S,4R-Monatin to form the 2R,4R-Monatin; and the... Agent: Ajinomoto Co., Inc.
20120208245 - Method for producing l-lysine using corynebacterium sp. that has obtained the activity of glyceraldehyde-3-phosphate dehydrogenase derived from an alien species: The present invention relates to a Corynebacterium sp. strain having an activity of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase and an improved productivity of L-lysine, and a method for producing L-lysine using the same. According to the Corynebacterium sp. strain of the present invention and the method for producing L-lysine using the same,... Agent: Cj Cheiljedang Corporation
20120208247 - Non-dispersive process for insoluble oil recovery from aqueous slurries: The development and application of a novel non-polar oil recovery process utilizing a non-dispersive solvent extraction method to coalesce and recover oil from a bio-cellular aqueous slurry is described herein. The process could apply to recovery of algal oil from a lysed or non-lysed algae slurry, recovery of Omega fatty... Agent: Board Of Regents, The University Of Texas System
20120208246 - Production of alcohol esters and in situ product removal during alcohol fermentation: An alcohol fermentation process and composition that includes production of alcohol esters by esterification of product alcohol in a fermentation medium with a carboxylic acid (e.g., fatty acid) and a catalyst (e.g., lipase) capable of esterifying the product alcohol, such as butanol, with the carboxylic acid to form the alcohol... Agent: Butamax(tm) Advanced Biofuels LLC
20120208248 - Fermentation of moderately thermophilic bacilli on sucrose: A method for the construction of a moderately thermophilic Bacillus strain capable of utilising sucrose as a carbon source includes the transformation of a parent moderately thermophilic Bacillus strain not capable of utilising sucrose as a carbon source with a polynucleotide comprising a DNA sequence that encodes a polypeptide having... Agent:
20120208249 - Microorganisms and methods for conversion of syngas and other carbon sources to useful products: A non-naturally occurring microbial organism having an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway includes at least one exogenous nucleic acid encoding an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway enzyme expressed in a sufficient amount to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol. The aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol.... Agent: Genomatica, Inc.
20120208250 - Process for producing alcohol and other bioproducts from biomass extracts in a kraft pulp mill: A method for the production of alcohol and other bioproducts from power boiler woody biomass extract containing hemicelluloses, with or without combining extract from wood prior to Kraft cooking. The process is integrated with the host Kraft pulp mill plant process to minimize the heat loss from extracting hemicelluloses and... Agent: Api Intellectual Property Holdings, LLC
20120208251 - Alpha-amylase variant with altered properties: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.... Agent: Novozymes A/s
20120208252 - Process and system for producing ethanol from a byproduct of an ethanol production facility: A process of producing ethanol from whole stillage, includes obtaining a supply of whole stillage from an ethanol production facility after ethanol has been extracted therefrom; pre-treating the whole stillage to convert hemicellulose portions of the whole stillage into sugars; adding enzymes to the whole stillage to convert cellulose portions... Agent: Quad County Corn Processors
20120208253 - Methods and compositions for producing alkenes of various chain length: The NonA alkene synthase in Synechococcus sp. displays selective synthesis of 1-nonadecene. Heterologous recombination of a domain, i.e. the acyl binding domain, with other acyl binding proteins, affects acyl substrate chain-length binding selectivity and therefore the chain-length of the synthesized 1-alkenes. Compositions and methods are provided to selectively synthesize 1-alkenes... Agent: Joule Unlimited Technologies, Inc.
20120208254 - Biorefinery system, components therefor, methods of use, and products derived therefrom: Embodiments of the present disclosure provide systems, components, methods directed to generating energy and output products from biomass in a biorefinery system. The systems, components, and methods can be used alone or in combination as part of an integrated biorefinery system.... Agent: Algae Aqua-culture Technology, Inc.
20120208255 - Apparatus and process for production of an encapsulated cell product: A process for production of an encapsulated cell product, the process comprises the steps of concentrating cells from a propagation medium using a tangential flow filtration system. Mixing the concentrated cells with an encapsulation medium to form a cell encapsulation mixture. Polymerizing, gelling, or cross-linking the cell encapsulation mixture to... Agent: Geosynfuels, LLC
20120208256 - Enzyme-functionalized supports: An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional... Agent: Gambro Lundia Ab
20120208257 - Additive for bioleaching that is substantially made up of the licanantase lipoprotein, and bioleaching process to which this additive is added to increase the recovery of copper: The invention discloses an additive for bioleaching that makes it possible to increase the recovery of copper from sulfide ores. In which this additive is substantially made up of the Licanantase lipoprotein and a solution of sulfuric acid with a pH of 0.8 to 3. The Licanantase lipoprotein that has... Agent: Biosigma S.a.
20120208258 - Conjugate of catechol-modified polyethylene glycol with protein or peptide and preparation method therof: The present invention relates to a conjugate of a protein or peptide with a polyethylene glycol derivative having catechol, wherein the protein or peptide is mono-PEGylated at the N-terminal with the polyethylene glycol derivative, and to a preparation method thereof. According to the invention, the catechol-PEG derivative can be site-specifically... Agent: Korea Advanced Institute Of Science
20120208259 - Halohydrin dehalogenases and related polynucleotides: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.... Agent: Codexis, Inc.
20120208260 - Novel lactobacillus plantarum and composition comprising the same: Lactobacillus plantarum CJLP243 (KCTC 11045P), a composition for treating intestinal diseases comprising Lactobacillus plantarum CJLP243, and a composition for enhancing immune response comprising Lactobacillus plantarum CJLP243.... Agent: Cj Cheiljedang Corp.
20120208261 - Method of removing heavy metals in soils and water: A method for sulfurous acid leaching of heavy metals from soils into a contaminated water fraction for subsequent precipitation with alkaline and nutrient reagents for filtration removal to provide a metal free soil and reclaimed water suitable for raising crops and open stream discharge.... Agent: Earth Renaissance Technologies LLC
20120208262 - Biotrickling filter for treating waste gas and treating method using the same: A biotrickling filter for treating waste gas including a waste gas inlet, packing layers, a spray pipe, a spray liquid storage tank, and a waste gas outlet. The waste gas passes through a first packing layer after passing through the waste gas inlet and then passes through a second packing... Agent:
20120208263 - Device for monitoring a plurality of discrete fluorescence signals: The present invention relates to a device and detector for monitoring a plurality of discrete fluorescence signals, in particular for DNA sequencing by use of fluorescently labeled nucleotides. The particular detector (118) is proposed comprising a plurality of pixels (130) for individually detecting said fluorescence signals from the plurality of... Agent: Koninklijke Philips Electronics N.v.
20120208264 - Method and apparatus for detection of livign phytoplankton cells in water: The invention relates to a method and an apparatus for detecting living phytoplankton cells and/or microorganisms in or out of water, particularly ballast water, bodies of water, sewage, or water in swimming and bathing devices. Said method is characterized by the following steps: the variable fluorescence (Fv) is calculated by... Agent: Rwo Gmbh
20120208265 - 3d microstructuring for generating mixed structures and channel structures in multilayer technology for use in or for the construction of reactors: The present invention relates to a channel structure for a bioreactor, biochemical reactor, chemical reactor or a reformer comprising a plurality of individual layers stacked on one another and having a respective plurality of openings which pass completely through the respective individual layer and which are characterized in that at... Agent:
20120208266 - Enzyme cleavable cell release polymeric surface: Disclosed herein are cell culture surfaces comprising a substrate and a polymer layer on the substrate where the polymer layer contains enzyme-cleavable amino acid sequences and cell adhesive peptide sequences.... Agent:
20120208267 - System for synergistic expression of multiple small functional rna elements: The present invention relates in general to microRNAs (miRNAs). More specifically, the invention relates to expression vectors comprising multiple miRNAs or families and, clusters capable of targeting multiple oncogenic pathways.... Agent: University Of Southern California
20120208268 - Media and method for cell separation: The present invention relates to a separation media and a method for separation of cells from different cell sources, such as umbilical cord blood, using the separation media to obtain the desired cells, such as stem cells. The separation media has beads with a diameter of 200-500 μm and is... Agent: Ge Healthcare Bio-sciences Ab
20120208269 - Method of isolating dermal stem cells: The invention provides a method of isolating dermal stem cells, having the steps of subjecting cells separated from the skin by enzyme treatment to suspension culture, and isolating cells positive for stem cell markers from the cultured cells.... Agent: Shiseido Company, Ltd.
20120208270 - Poly-n-acetyl glucosamine (pnag/dpnag)-binding peptides and methods of use thereof: The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express... Agent: The Brigham And Women's Hospital, Inc.
20120208272 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.
20120208271 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.
20120208274 - Adipose-derived stem cells and lattices: The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells.... Agent:
20120208273 - Vessel for culturing cells: The present invention provides an apparatus for culturing cells which may comprise two or more culture compartments and a pooling compartment, wherein each of said two or more culture compartments may be separated from the other culture compartments; each of said two or more culture compartments which may comprise a... Agent:
20120208275 - Methods for co-culturing cord blood cells or cord tissue with menstrual multipotent cells: Methods are provided for obtaining expanded human cord blood cells or cord tissue cells expressing CD34. The methods involve seeding a sufficient amount of human cord blood cells or cord tissue cells with a sufficient amount of menstrual cells under co-culture conditions suitable to promote expansion of the cord cells,... Agent: Cryo-cell International, Inc.
20120208276 - Tissue engineering supports and methods therefor: The present disclosure relates to supports and scaffolds for cell and tissue engineering. The supports disclosed herein are composed of a thermally responsive material, containing pillars, that is coated with an acrylic polymer, thereby imparting an amphipathic matrix foundation. When exposed to a change in temperature, the coated support reacts... Agent:
20120208277 - Novel dna cloning method relying on the e.coli rece/rect recombination system: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with... Agent: Europaisches Laboratorium Fur Molekularbiologie (embl)
20120208278 - Innate immune suppression enables repeated delivery of long rna molecules: The present invention relates in part to methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid, to methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and... Agent: Massachusetts Institute Of Technology
20120208280 - Brucella phage polynucleotides and uses thereof: An isolated polynucleotide is disclosed which comprises a nucleic acid sequence of a Brucella phage, the nucleic acid sequence being specific to the Brucella phage and comprising a sequence selected from the group consisting of SEQ ID NOs: 387-393. An exemplary polyncucleotide sequence is one which comprises at least 100... Agent: The State Of Isreal, Ministry Of Agriculture & Rural Development, Kimron Veterinary Institute
20120208279 - Transformation of algal cells: Exemplary methods include a method for transforming an algal cell by preparing a transformation construct, preparing a particle for bombarding the algal cell, adhering the transformation construct to the particle, bombarding the algal cell with the particle, and growing the algal cell into a colony. The transformation construct is replicated... Agent:
20120208281 - Method for incorporation of recombinant dna: The invention provides methods of preparing bacteria of interest with a stably integrated nucleic acid sequence of interest.... Agent: Eastman Renewable Materials, LLC08/09/2012 > 105 patent applications in 56 patent subcategories.
20120202188 - Serum-based biomarkers of pancreatic cancer and uses thereof for disease detection and diagnosis: Biomarkers of pancreatic cancer are described, as well as methods using these compounds for detecting pancreatic cancer. The methods can be used to diagnose a patient's health state, or change in health state, or for diagnosing risk of developing or the presence of pancreatic cancer. The method comprises analyzing a... Agent: Phenomenome Discoveries Inc.
20120202191 - Detection method based on time resolved real time fluorescent energy transfer (tr-fret): A method for detecting the presence of a diagnostic moiety indicative of exposure to an infectious organism in a biological sample taken from a human or animal, said method comprising use of a first and second fluorescently labelled reagent which are capable of binding to a diagnostic moiety or to... Agent: The Secretary Of State For Environment, Food & Rural Affairs
20120202190 - Detection of hepatitis b virus in blood using lamp method: A method for detection blood borne pathogen in whole blood, comprising collecting a blood sample from a subject, heating said sample for a period of time, adding said heated sample to a pre-mixed LAMP solution comprising one or more LAMP primer set, and Bst DNA polymerase to create a reaction... Agent:
20120202193 - Disposable device for storing biological liquids and use thereof to detect materials, particles, and/or cells: The device according to the invention for obtaining, storing and processing substances extracted from liquids consists of a cylinder for holding the liquids; solid carriers; seals on both ends of cylinders which can be perforated with a hollow needle, where at least one of the seals is formed as a... Agent:
20120202192 - Hyper-spectral imaging and analysis of a sample of matter, for identifying and characterizing an object of interest therein: Method for hyper-spectral imaging and analysis of a sample of matter, for identifying and characterizing an object of interest therein. Preparing test solution or suspension of the sample, including adding thereto a spectral marker specific to object of interest, such that if object of interest is in test solution or... Agent: Green Vision Systems Ltd.
20120202189 - Rapid, semi-automated method to detect respiratory virus infected cells in direct specimens: A novel cytometer system, methods and algorithms which provide a rugged, affordable and easy-to-use device in remote locations. All cells in a biological sample are fluorescently labeled, with target cells also magnetically labeled. Non-magnetically labeled cells are imaged for viability. Labeled sample is placed between two wedge-shaped magnets to selectively... Agent: Immunivest Corporation
20120202194 - Substance determining apparatus: The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles, which have attached the substance, are bound to a binding surface (30). A sensing unit (33) is adapted to generate a sensing signal being indicative of at least one of i) a distance between... Agent: Koninklijke Philips Electronics N.v.
20120202197 - Efficient proliferation method for a kupffer cell and use thereof: The present invention has successfully established a mixed culture system capable of actively proliferating a Kupffer cell in a primary culture of a cell population derived from a liver. Additionally, the present invention has successfully established a novel production method for efficiently producing a large amount of highly purified Kupffer... Agent: National Institute Of Agrobiological Sciences
20120202196 - Labelled nucleotides: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.... Agent: Illumina Cambridge Limited
20120202195 - Nucleic acid element for use in analysis, and analytical method, analytical reagent, and analytical instrument using same: The technique by which simple analysis of an intended subject to be analyzed can be carried out is provided. In this technique, a nucleic acid element 16 for use in analysis including: a first nucleic acid part 12; and a second nucleic acid part 13 is used. In the nucleic... Agent: Nec Soft, Ltd.
20120202204 - assay for determining a molecular risk assessment of a complex polymicrobial sample suspected to contain an ehec: The present invention relates to a process to perform a molecular risk assessment (MRA) upon a sample suspected to contain an enterohemorrhagic Escherichia coli (EHEC), comprising the steps: contacting said sample or DNA isolated therefrom with a pair of primers derived from the following target genes stx1, stx2, eae and/or... Agent:
20120202209 - Cell imaging method for viewing microrna biogenesis in the cells: The present invention relates to a method for viewing the biogenesis of at least one microRNA, preferably a microRNA group, in a living cell, characterised in that said method includes the following steps: transforming said cell by an encoding vector for a protein selected among the DGCR8 protein (DiGeorge syndrome... Agent: Centre National De La Recherche Scientifique - Cnrs
20120202201 - Device and method for analysis of kidney failure: The invention provides a method for analysis of the status of kidney function in a sample of body fluid obtained from a patient who has not been diagnosed with acute kidney injury (AKI, also referred to as acute kidney failure) or in a sample of body fluid obtained from a... Agent: Medizinische Hochschule Hannover
20120202205 - Diagnostic methods: This invention relates to a method of determining the susceptibility of an individual to statin-induced myopathy, comprising detecting the presence or absence of one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual, whereby the presence of one or more polymorphisms indicates that the individual... Agent:
20120202207 - Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of... Agent: The Johns Hopkins University
20120202200 - Methods for detecting human papilloma virus-associated cancers: The present invention provides probes and methods of use thereof in the diagnosis and/or prognosis of certain types of cancers, particularly human papillomavirus (HPV)-associated cancers. The probes are designed for hybridization with genomic material in a manner indicative of one or more aberrations in the genetic material present in the... Agent: Cancer Genetics, Inc.
20120202202 - Methods for detecting rare circulating cancer cells using dna methylation biomarkers: Provided are new and improved methods for detecting circulating tumor cells and tumor cell DNA in patient blood or other biofluid samples. Particular aspects comprise three steps: DNA extraction from patient samples, DNA digestion with multiple selected methylation-sensitive enzymes, and target amplification by a conventional or a real-time PCR with... Agent:
20120202208 - Nucleic acid and corresponding protein entitled 193p1e1b useful in treatment and detection of cancer: A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The... Agent: Agensys, Inc.
20120202206 - Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors: Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors.... Agent: Technion Research & Development Foundation Ltd.
20120202198 - Process for the synthesis of a cdna in a sample in an enzymatic reaction: This invention relates to a process for synthesis of a cDNA in a sample, in an enzymatic reaction, whereby the process comprises the steps: simultaneous preparation of a first enzyme with polyadenylation activity, a second enzyme with reverse transcriptase activity, a buffer, at least one ribonucleotide, at least one deoxyribonucleotide,... Agent: Qiagen Gmbh
20120202203 - Single probe, multiple temperature, nucleic acid detection methods, kits, and compositions: Provided herein are methods, kits, and compositions related to nucleic acid detection assays that allow discrimination of multiple target sequences with a single probe. In particular, provided herein are methods kits, and compositions that include single-probe target sequence discrimination where different target amplicons may have identical probe hybridization sequences by... Agent: Brandeis University
20120202211 - Apparatus and method for biologic sample rapid collection and recovery device, and convenient storage: In accordance with exemplary embodiments, apparatus and method for biologic sample rapid collection and recovery device, and convenient storage are provided. An exemplary embodiment includes an apparatus comprising a lateral flow technology device including at least a membrane configured to bind an analyte from a sample that flows through the... Agent: The Board Of Regents For Oklahoma State University
20120202210 - Biohazard detection system with exhaust stream recycling: A system capable of detecting low-level releases of bio-agents and other harmful substances contained in air concentrates and recycles exhaust air from a collector in order to entrain and retain more particles from an aerosol release event. The system ensures that particles that were not initially entrained or subsequently retained... Agent: Northrop Grumman Systems Corporation
20120202214 - Method for detecting fusion gene: Disclosed is a means which enables simple and rapid detection of the presence of any fusion genes including even unknown fusion genes. The method for measuring a fusion gene(s) according to the present invention is applied to a sample separated from a living body, and comprises: measuring expressions of a... Agent:
20120202212 - Methods for genetic composition analysis of natural products: Provided herein are novel methods for identifying component species in a natural product using genetic testing methods.... Agent:
20120202213 - Oligonucleotides for amplifying chlamydophila pneumoniae nucleic acid: Amplification oligonucleotides for use in amplifying a sequence contained in nucleic acid derived from Chlamydophila pneumoniae.... Agent: Gen-probe Incorporated
20120202215 - Mitochondrial function of prohibitin 2 (phb2): The present invention relates to a PHB2 gene regulator and a therapeutic drug for mitochondrial-function-related disease containing the same, for example.... Agent: Jichi Medical University
20120202217 - Autoantibody enhanced immunoassays and kits: The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies reactive with the analyte... Agent: Abbott Laboratories
20120202216 - Novel photoactivable fluorescent dyes for optical microscopy and imaging techniques: The present invention relates to novel photoactivable rhodamine or carbopyronine derivatives of the following general formulae G1-G4 (I), G1: A1=O, A2=N, A3=C; G2: A1=S, A2=N, A3=C; G3: A1=O, A2=O, A3=N; G4: A1=S, A2=O, A3=N; comprising UV light absorbing chromophores which after photolysis by irradiation at 254-490 nm (preferably at 375-420... Agent: Max-planck-gesellschaft Zur Foerderung Der Wissenschaften E.v.
20120202222 - Enzyme fragment complementation assays for monitoring the activation of the voltage-gated potassium ion channel herg: The present invention provides methods and cell based assays for testing for the binding of a ligand to a human Ether-a-go-go-related (hERG) voltage-gated potassium ion channel protein in an enzyme complementation assay. The invention is of particular use in toxicological and drug screening, particularly for high throughput screening.... Agent: Ge Healthcare Uk Limited
20120202220 - Multivalent fluorescent probes: Multivalent fluorescent probes and methods of using these multivalent fluorescent probes for in vitro and in vivo imaging are described.... Agent: Caliper Life Sciences
20120202221 - Natural peptide and derivatives as modulators of gpcr gpr1 and uses thereof: The invention relates to the identification of Humanin and derivatives thereof as ligands of the GPR1 GPCR (G-protein coupled receptor). The invention encompasses the use of the interaction of GPR1 polypeptides and Humanin polypeptides as the basis of screening assays for agents that modulate the activity of the GPR1 receptor.... Agent: Actelion Pharmaceuticals Ltd.
20120202223 - Ki-67 assay for patient immune system status: Novel diagnostic assay based on the detection of Ki-67 expression to anticipate the response to anti-HIV therapy... Agent:
20120202224 - Polypeptide variants with altered effector function: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.... Agent:
20120202225 - Methods and devices for immunodiagnostic applications: Methods and devices for evaluating a sample from a subject for detecting a target red blood cell protein or antibody are disclosed. In one embodiment, optimized antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood... Agent: Arryx, Inc.
20120202218 - Detection method and device based on nanoparticle aggregation: A method for determining the presence of a compound in a liquid solution, by admixing the liquid solution with a plurality of nanoparticles; providing conditions effective to cause aggregation of the nanoparticles in the liquid solution in the absence of said compound in the liquid solution; and observing a detectable... Agent: Modpro Ab
20120202219 - Psa capture agents, compositions, methods and preparation thereof: Disclosed herein are novel synthetic prostate specific antigen (PSA)-targeted capture agents that specifically bind PSA. In certain embodiments, these PSA capture agents are biligand or triligand capture agents containing two or three target-binding moieties, respectively.... Agent:
20120202226 - method and system for the detection of cancer: Disclosed are a method and kit of diagnosis of cancer in a body sample of a subject, comprising contacting the sample with at least two different suitable antigens to form at least two different complexes with antibodies present in the sample, determining the actual levels of each of said antigen-antibody... Agent: Eventus Diagnostics Israel Ltd.
20120202228 - Antibody profiles characteristic of tuberculosis state: Serum antibody assays capable of distinguishing cases of inactive TB from cases of active TB include a combination at least three M. tuberculosis protein antigens, at least one for which a positive response is consistent with inactive TB and antigens, and at least one for which a negative response is... Agent: University Of Medicine And Dentistry Of New Jersey
20120202227 - Babesia microti genomic clones containing novel antigens useful in the diagnosis of babesiosis: Disclosed are the cloning and expression of novel antigens in Babesia microti. The recombinant polypeptides are highly immunogenic. The polypeptides of the present invention provide the basis of a diagnostic assay that is sensitive, rapid and accurate using patient's sera. Also disclosed is an IgG and IgM ELISA using two... Agent: Medical Diagnostic Laboratories, LLC
20120202229 - Immunoassay tracer reagents and methods for measuring the amount of native human bioactive hepcidin: The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive... Agent: Intrinsic Lifesciences LLC
20120202230 - Liquid reagent of thyroid hormone-immobilized carrier and use thereof: A liquid reagent of a stabilized thyroid hormone-immobilized carrier, by which a thyroid hormone can be measured easily in a short time and at low cost, is provided. The liquid reagent of a thyroid hormone-immobilized carrier according to the present invention includes: a thyroid hormone-immobilized carrier; and a solvent, and... Agent: Arkray, Inc.
20120202231 - Synergistic biomarker assay of neurological condition using s-100b: Processes and assays are provided for detecting and determining the magnitude of traumatic brain injury such as that from impact or percussive trauma or stroke. The inventive assays and processes recognize a synergistic correlation between detection of S-IOOb and one or more other injury specific biomarkers.... Agent:
20120202232 - Heparin-insensitive method for determining direct coagulation factor inhibitors: The invention is in the field of coagulation diagnostics and relates to a heparin-insensitive method for determining direct coagulation factor inhibitors in a sample, in particular direct thrombin and factor Xa inhibitors.... Agent: Siemens Healthcare Diagnostics Products Gmbh
20120202234 - Methods and composition for isoprenoid diphosphate synthesis: Provided herein are methods and compositions relating to the synthesis of isoprenoid diphosphates using a mutated isopentenyl phosphate kinase.... Agent: The Salk Institute For Biological Studies
20120202233 - Methods and uses of ksr kinase, and mutations thereof: Mutant KSR proteins are disclosed. The mutants include single amino acid substitutions, leading to either a loss of kinase activity or a loss of scaffolding activity. Also disclosed are methods of screening compounds for inhibitors of KSR kinase activity or KSR scaffolding activity. In some embodiments, the screening methods include... Agent: Washington University
20120202235 - Novel fructosyl peptidyl oxidase: In one form, a fructosyl peptidyl oxidase derived from a budding yeast Phaeosphaeria nodorum for assaying a glycated protein in a sample is provided. The fructosyl peptidyl oxidase has higher activity toward fructosyl valine as well as fructosyl valyl histidine, and may be useful in assaying HbA1c with higher sensitivity... Agent:
20120202236 - Composite animal litter material and methods: A composite litter material for detecting a disease, such as urinary tract disease, when contacted by feline urine includes an absorptive polymer material forming a solid matrix, exfoliated clay embedded and dispersed within the solid matrix, a chromogenic indicator provided within the solid matrix, and an oxidizing agent distributed and... Agent: 7905122 Canada Inc.
20120202238 - Determining conditions in centrifuged blood using measured pressure: A method for determining a condition in a blood sample includes: providing a sample of blood; providing a metering probe having a pump for aspirating and dispensing; inserting the metering probe a selected distance into the blood sample; measuring the pressure between the sample and pump during sample aspiration or... Agent:
20120202239 - Materials, monitoring, and controlling tissue growth using magnetic nanoparticles: Systems and method for releasing a biological factor in a tissue or organ are disclosed. The system includes one or more nanoparticles distributed in the tissue or organ, the nanoparticles including the biological factor; and a magnetic field generator configured to generate a magnetic field at a first frequency and... Agent:
20120202240 - Method for predicting the likelihood of an onset of an inflammation associated organ failure: The present invention relates to a reliable and statistically significant method for predicting the likelihood of an onset of an inflammation associated organ failure from a biological sample of a mammalian subject in vitro, by means of a subject's quantitative metabolomics profile comprising a plurality of endogenous metabolites, and comparing... Agent: Biocrates Life Sciences Ag
20120202237 - Particle sorting apparatus and method: A particle analyzing and/or sorting apparatus and the associated methods. One aspect of the described embodiments relates to an analyzer, or a sorter, having acquisition and sort electronics in the form of a field programmable gate array for processing detected signals. Another aspect relates to a droplet based approach of... Agent: Cytonome/st, LLC
20120202241 - Histological specimen treatment apparatus and method: Method and apparatus for processing tissue specimens against decomposition, putrefaction and autolysis which use a simple three step procedure in a single vessel or container. First, the specimens are saturated with a solvent mixture of a ketone and a hydrocarbon, e.g., an Acetone/Hexane or an Acetone/Xylene mixture, to dissolve lipids... Agent:
20120202242 - System and method for non-sterile heterotrophic algae growth: A system and method for non-sterile heterotrophic algae growth is provided. The system includes a first Continuous Stirred Tank Reactor (CSTR), kept under sterile conditions, for mixing a full load nutrient with algae cells to create a culture. After being transferred to a first Plug Flow Reactor (PFR), a nutrient... Agent:
20120202243 - in vivo incorporation of unnatural amino acids: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.... Agent: The Scripps Research Institute
20120202244 - Antibodies capable of specifically binding to a specific amino acid sequence: The present invention provides for an antibody or fragment thereof capable of specifically binding to an epitope of the amino acid sequence CDPAFLYKVVD (SEQ ID NO:1) or a fragment of at least 5, 6, or 7 amino acids thereof.... Agent: The Regents Of The University Of California
20120202245 - Method for producing natively folded proteins in a prokaryotic host: The present invention relates to a method for producing a protein of interest containing one or more disulfide bonds in its native state. The method comprises that a prokaryotic host cell is genetically engineered to express the protein of interest and a sulfhydryl oxidase in the cytoplasm of the host... Agent: University Of Oulu
20120202247 - Method, computing routine, device for predicting properties of mhc/peptide complexes, and data and peptides produced therefrom: The present invention relates to a method for structure-based prediction of properties of peptides and peptide analogs in complex with major histocompatibility (MHC) class I and class II molecules. The said properties mainly relate to the three-dimensional structure of an MHC/peptide complex and the binding affinity of a peptide for... Agent: Algonomics N.v.
20120202248 - Novel hansenula polymorpha gene coding for dolichyl-phosphate- mannose dependent alpha-1,3 mannosyltransferase and process for the production of recombinant glycoproteins with hansenula polymorpha mutant strain deficient in the same gene: The present invention relates to a process for producing a human-type glycoprotein having reduced glycosylation by genetically manipulating an enzyme involved in glycosylation using a Hansenula polymorpha system. In detail, the present invention relates to a process for producing a human-type glycoprotein by identifying a dolichyl-phosphate-mannose dependent α-1,3-mannosyltransferase gene from... Agent: Korea Research Institute Of Bioscience And Biotechnology
20120202246 - Vector comprising mannose promoter and mannose promoter: The present invention relates to a vector expressible in a prokaryotic host and a nucleic acid sequence comprising a mannose-inducible promoter of the mannose operon of Bacillus subfiles wherein the vector and nucleic acid sequence, respectively, can be suitably used for transforming a host cell for expression of a heterologous... Agent: Lonza Ag
20120202249 - Production of an intact virus in a mammalian (non-host) cell system using a secondary non-host viral construct: The present invention relates to constructs and methods for the production of recombinant proteins, viruses, and viral vaccines in heterologous culture systems by expressing intact genes or viral genomes under the control of a pantropic promoter in a culture system that is not considered a host to the virus so... Agent:
20120202250 - Method for exponential amplification of rna using thermostable rna-dependent rna polymerase: The present invention relates to a method for exponential amplification of RNA in vitro by using a thermostable RNA-dependent RNA polymerase (RdRp) of a sapovirus or norovirus.... Agent: Riboxx Gmbh
20120202251 - In vivo assembly of dna via homologous recombination: According to the present invention, a DNA construct of interest is assembled from overlapping subfragments via an acceptor module which comprises the distal end of the construct at a position downstream from a promoter. The construct is assembled distal to proximal via homologous recombination events occurring in the span between... Agent:
20120202253 - Alcohol sulfite biorefinery process: A biorefinery process to fractionate lignocellulosic materials into cellulose, hemicelluloses and lignin using a pretreatment with mixture of alcohol, sulfur dioxide and water. Further treatment with enzymes, micro-organisms, and optionally bisulfite ion, are used to convert intermediate products to alcohol and lignin derivatives.... Agent: Api Intellectual Property Holdings, LLC
20120202252 - Effect of radiation on cellulase enzymes: A method for recycling cellulase enzymes. Also provided is a method for producing fermentable carbohydrates, plant leaf protein, and lignin, by adding a cellulase enzyme complex expressed from and on irradiated cellulase complex-producing organisms with sufficient radiation to kill biological activity without destroying all cellulase enzyme complex activity to biomass.... Agent:
20120202254 - Method for producing lactic acid by non-sterile fermentation: The present invention relates to a method for producing lactic acid from plant biomass without requiring sterilization, and specifically relates to a method for producing lactic acid comprising culturing alkaliphilic lactic acid bacteria under non-sterile condition and at a pH of 9 to 11 in a medium containing a cellulose... Agent: National Institute Of Advanced Industrial Science And Technology
20120202255 - Method for producing an l-amino acid: A method for producing an L-amino acid by preparing a processed product of a microalgae, which promotes production and accumulation of the L-amino acid by a bacterium having an ability to produce the L-amino acid, by culturing the microalgae in a medium, and processing the resulting culture at a midtemperature;... Agent:
20120202256 - Novel preparation method of human metabolites of simvastatin or lovastatin using bacterial cytochrome p450 and composition therefor: A method of producing human metabolites of simvastatin or lovastatin, and more particularly, a method of producing human metabolites of simvastatin and lovastatin by using bacterial cytochrome P450 BM3(CYP102A1) or mutants thereof, and a composition and kit therefor.... Agent: Glo Biotech
20120202257 - Lige-type enzymes for bioconversion of lignin-derived compounds: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as... Agent:
20120202258 - Lige-type transformants for bioconversion of lignin-derived compounds: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as... Agent:
20120202259 - Metabolic evolution of escherichis coli strains that produce organic acids: This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires... Agent: Myriant Corporation
20120202260 - Hybrid biorefining and gasification of lignocellulosic feedstocks: Processes and systems for concurrent recovery of lignin derivatives and syngas from a lignocellulosic feedstock. The processes and systems therefor generally comprise the steps of: (a) perfusing and cooking the lignocellulosic feedstock with a suitable organic solvent for a suitable period of time thereby producing a cellulosic solids output stream... Agent: Lignol Innovations Ltd.
20120202261 - 3d trophoblast matrix for preparing organ-specific stem cells: This disclosure relates generally to methods, apparatuses, and cellular compositions and cellular products that use a unique trophoblast-containing 3D matrix as a compartmental chamber for growing embryoid bodies that can be induced to differentiate into organ-specific cell types.... Agent: Empire Technology Development LLC
20120202263 - Bioactive macromers and hydrogels and methods for producing same: The invention concerns macromers, having a molecular weight of at least 2 kDa, comprising at least one unit of the formula P-(protein-P)n, wherein: P is selected from polyethylene glycol (PEG), alginate, polyurethane, and polyvinyl alcohol; protein comprises at least one bis-cysteine matrix metalloproteinase (MMP)-sensitive peptide; and n is an integer... Agent: The Trustees Of The University Of Pennsylvania
20120202264 - Inhibitors of il2-inducible t-cell kinase: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.... Agent: Pharmacyclics, Inc.
20120202262 - Process for production of an enzyme product: The invention relates to a process for production of an enzyme product having a plurality of enzyme activities obtained by fermentation of an Aspergillus strain.... Agent: Danisco A/s
20120202265 - Methods for reducing blue saccharide: The present disclosure relates to a Bacillus subtilis alpha-amylase (AmyE) or its variant thereof. AmyE or its variants thereof may be used to eliminate or reduce the iodine-positive starch presented in saccharide liquor. Also disclosed are a composition comprising an AmyE or variant thereof and a method utilizing an AmyE... Agent:
20120202266 - Polypeptides having endoglucanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes A/s
20120202267 - Method for the purification of adenovirus particles: The invention provides methods for large-scale adenovirus purification from high cell density suspensions, using host cell DNA precipitation followed by a clarification step.... Agent:
20120202268 - Process for adenovirus purification from high cell density cultures: The invention provides methods for large-scale adenovirus purification from high cell density suspensions, using host cell DNA fragmentation and/or precipitation followed by a clarification step with tangential flow filtration.... Agent: Crucell Holland B.v.
20120202269 - Gelatinous substance based growth medium filtration device and method: Growth medium filtration devices are provided which are particularly well adapted to sterilize gelatinous substance based growth mediums including agar, agarose and other polysaccharide derived growth mediums for use in agar plates and the like for culturing microorganisms. The devices may include one or more filtration units and at least... Agent: Toku-e Company
20120202271 - Method producing an immune response for reducing the risk of developing brucellosis: This invention relates to unique antigens in a brucellosis vaccine which Provide an immune response against bacteria which cause brucellosis in cattle and Other animals. The vaccine specifically uses Bp26 and LeuB expressed to create the immunity.... Agent:
20120202270 - Producing an immune response for reducing the risk of developing brucellosis: This invention relates to unique antigens in a brucellosis vaccine which Provide an immune response against bacteria which cause brucellosis in cattle and other animals. The vaccine specifically uses L7L12, 85A, Bp26 and/or LeuB and may or may not include GFP with any combination of polypeptides... Agent:
20120202272 - Lige-type systems for bioconversion of lignin-derived compounds: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as... Agent:
20120202273 - Enzymatic conversion of blood group a, b, and ab red blood cells using alpha-n-acetylgalactosaminidases and alpha-galactosidases with unique substrate specificities and kinetic properties: This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique α-N-acetylgalactosaminidases and α-galactosidases with superior kinetic properties for removing... Agent:
20120202274 - Systems and methods for cultivating, harvesting and processing biomass: Combining controlled open-ocean iron enrichment with a system for collecting the ensuing biological growth can lead to a fundamental shift towards using marine biomass feedstock for large-scale global biodiesel production. The literature review reveals that open-ocean enrichment effectively reduces both the atmospheric carbon dioxide partial pressure and ocean acidity. A... Agent:
20120202275 - System and method for removing airborne contaminants from exhaust gas: The present invention provides a system and method for purifying and/or filtering gases. The system and method remove undesired species from a gas through the use of bioorganisms which reside in and on a filtration media. Water and nutrients can be supplied to the filtration media to promote the growth... Agent:
20120202276 - Modified proteins and methods of making and using same: Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for... Agent: Life Technologies Corporation
20120202277 - Minimally invasive cytometry system with qcl inspection of single cells for cancer detection: This disclosure concerns a minimally invasive cytometry system including a handling system that presents single cells to at least one QCL laser source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce vibrational bond absorption in one or more analytes... Agent: 1087 Systems, Inc.
20120202278 - System and method for repeat measurement of single cells using vibrational spectroscopy: This disclosure concerns a high-throughput cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light successively to single cells over a time period in order to make successive measurements of induced resonant... Agent: 1087 Systems, Inc.
20120202279 - Onsite integrated production factory: An onsite integrated production factory having an electrolytic plant, an ethanol plant, a vegetable plant, a culturing plant, and a power generation unit. The onsite integrated production facility is arranged so that fresh water, sulfuric acid or caustic soda produced by and received from the electrolytic plant is used in... Agent: M Hikari & Energy Laboratory Co., Ltd.
20120202280 - Treatment system of wet organic waste: Provided is a treatment system whereby a wet organic waste can be effectively treated and CO2 produced in the course of the treatment can be immobilized to thereby contribute to the reduction of CO2. The treatment system is characterized by including microbiologically fermenting a wet organic waste in a fermentation... Agent:
20120202282 - Gravity flow tubular photobioreactor and photobioreactor farm: A gravity flow photobioreactor core (10) comprised of a support means (3); a tube (5) that continuously runs and curls with declination about a vertical axis to form a stack (7) of levels (9) and having an inlet sparge (11); a gas exchange tank (13) and a central feed pipe... Agent: Advanced Algae, Inc.
20120202281 - Light energy supply for photobioreactor system: Photobioreactor systems including a supply material processing sub-system, a reactor sub-system, a product material processing sub-system, and a solar energy supply sub-system are provided. The reactor sub-system includes a photobioreactor configured for containing a reaction mixture that is operative for effecting photosynthesis upon exposure to photosynthetically active light radiation. The... Agent: Pond Biofuels Inc.
20120202283 - Freeze-dried product for introducing nucleic acid, oligonucleic acid or derivative thereof: A freeze-dried product of a complex containing (i) a nucleic acid, an oligonucleic acid or a derivative thereof, (ii) polyethyleneimine and (iii) hyaluronic acid or chondroitin sulfate. The freeze-dried product can be used to introduce a nucleic acid or an oligonucleotide into a cell.... Agent:
20120202284 - Cell sorting apparatus and method: Apparatus and method for sorting cells is provided in which two or more cells are delivered along a flow path, the two or more cells including a first type of cells having a first mechanical stiffness and at least a second type of cells having a second mechanical stiffness different... Agent: Empire Technology Development LLC
20120202285 - Antibodies to il-6 and their uses: Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.... Agent: Pfizer Inc.
20120202286 - Rblif protein for use in embryonic stem cell cultures: Provided herein methods of maintaining an embryonic stem cell culture in an undifferentiated state, wherein the method includes culturing an embryonic stem cell on a rabbit feeder cell layer, wherein the rabbit feeder layer expresses a leukemia inhibitory factor (LIF) protein. Also provided are methods of maintaining an embryonic stem... Agent:
20120202288 - Compositions comprising cyclic amp enhancers and/or ep ligands, and methods of preparing and using the same: Provided are improved pharmaceutical compositions that comprise ligands or agonists to prostaglandin EP receptors, and/or cyclic AMP enhancers, and suitable organic solvents that are substantially free of methyl acetate, the compositions being provided for storage and/or use in an endotoxin-free vessel, such as a tube or PE bag. The compositions... Agent: Fate Therapeutics, Inc.
20120202287 - Stem cell culture methods: The invention provides methods for reversibly inhibiting stem cell differentiation wherein a compound of formula (I) is contacted with a stem cell. The invention further provides a method for preparing a culture medium, a culture medium supplement and a composition comprising a compound of formula (I).... Agent:
20120202289 - Separator device, deposition device and system for handling of somatic plant embryos: Methods and devices for separating fluid-suspended plant somatic embryos and embryogenic tissue based on differences in their fluid drag properties are disclosed. Deposition method and device for depositing plant somatic embryos into embryo receiver comprising growth substrate by means of a fluid jet is disclosed. An automated system for processing... Agent: Georgia Tech Research Corporation
20120202290 - Tubular photobioreactor: The invention relates to a tubular photobioreactor that has a core structure in the shape of a truncated cone and one or more transparent or translucent tubes which are helically wound around the outer surface and/or inner surface of the core structure. Said tubular photobioreactor is characterized in that the... Agent: Wacker Chemie Ag
20120202291 - Simplified basic media for human pluripotent cell culture: Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS cells from adult individuals under defined, xeno-free conditions are also described.... Agent:
20120202292 - Novel method to generate nutritional compounds from microalgae: The present invention relates to the application of genomics technology to generate nutritional compounds in algae, such as microalgae. The present invention discloses a novel method to modify algae to produce a variety of nutritional compounds. Specifically, this method utilizes microalgae genomics technology to manipulate the existing metabolic pathways in... Agent:08/02/2012 > 103 patent applications in 58 patent subcategories.
20120196270 - Methods for preserving an organ for transplantation using a hemoglobin-carbon monoxide complex: The present invention relates generally to methods of preserving an organ for transplantation. Specifically, the present invention is directed towards treating an organ with a hemoglobin-carbon monoxide complex to preserve the organ before transplantation.... Agent: Sangart, Inc.
20120196271 - Iris control system for conducting the identification of bacteria in biological samples: A system and a method for optimizing an iris setting, used in combination with a lamp, for each excitation wavelength for each carousel run in an apparatus for identifying and measuring bacteria in biological samples. The system includes a feedback control loop positioned between a filter wheel and an optical... Agent: Pocared Diagnostics Ltd.
20120196273 - Devices and method for enrichment and alteration of cells and other particles: The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present... Agent:
20120196277 - Diagnosis of liver pathology through assessment of protein glycosylation: Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting lectin binding on proteins in biological fluids, and comparing the detected lectin binding with reference values for the binding of lectin of such proteins in healthy or disease... Agent:
20120196274 - Materials and methods for genotyping and quantifying a high-risk human papillomavirus: Nucleic acids, assays, and methods for the detection and quantification of high risk HPV types are disclosed.... Agent: Qiagen Gaithersburg, Inc.
20120196276 - Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial... Agent:
20120196275 - Multicellular organotypic model of human intestinal mucosa: Disclosed are methods of preparing multi-cellular three-dimensional tissue constructs, that include fibroblasts, endothelial cells, lymphocytes and epithelial cells. The present methods may include embedding fibroblasts and endothelial cells in a matrix enriched with gut basement membrane proteins to form a cell containing matrix that is then added to a bioreactor... Agent:
20120196272 - Prediction of hcv viral kinetics in interferon-free treatment: The present invention is based on the discovery of associations that exist between single nucleotide polymorphisms (SNPs) on chromosome 19 and virological outcomes in a diverse population of patients with hepatitis C virus (HCV) who received interferon-free treatment.... Agent: Roche Molecular Systems, Inc.
20120196281 - Functionalized organotypic systems: The present invention provides an organotypic system comprising a portion of a retina containing live cells in a cultured in medium, wherein photosensitivity has been restored in at least some of said live cells. Methods of use thereof are also provided.... Agent:
20120196279 - Methods and compositions for nucleic acid sample preparation: Provided are methods and compositions for the production of double-stranded nucleic acids, which can optionally be used as templates in high-throughput sequencing systems. In certain embodiments, these templates do not require exogenous primers to facilitate initiation of polymerase-dependent nascent strand synthesis. In certain embodiments, these templates comprise a single-stranded or... Agent: Pacific Biosciences Of California, Inc.
20120196280 - Microfabricated device for metering an analyte: The present invention relates to a microfabricated device for metering an analyte comprising a nucleic acid sequence into a plurality of parallel reaction chambers for nucleic acid sequence amplification. The present invention further provides a method of metering an analyte into a plurality of parallel reaction units of an integrated... Agent: Norchip A/s
20120196278 - Rna polyphosphatase compositions, kits, and uses thereof: The present invention relates to the discovery of RNA 5′ polyphosphatase enzymes not previously described in the art, methods for discovery of said enzymes, compositions of said enzymes, methods for making said enzymes, and various methods and kits for using said enzymes for biomedical research, for human and non-human diagnostics,... Agent:
20120196286 - Method and apparatus for diagnosing age-related macular degeneration: Disclosed is a method for identifying an individual who has an altered risk for developing age-related macular degeneration comprising detecting an insertion/deletion polymorphism in the ARMS2 gene... Agent: University Of Regensburg
20120196284 - Method of measuring telomere length: Disclosed herein is a novel method of measuring telomere length comprising determining the DNA content (Dx) of a sample, determining the telomeric content (T) of a sample, and determining the value of T/Dx.... Agent: University Of Medicine And Dentistry Of New Jersey
20120196282 - Method of regenerating elastic fiber and screening method: A method of regenerating an elastic fiber according in the present invention is characterized in that the method comprises bringing an elastic fiber regenerating agent containing LTBP-4 into contact with a cell having the fiber regenerating ability. Preferably, the elastic fiber regenerating agent further contains DANCE and/or LTBP-4 expression potentiating... Agent:
20120196285 - Methods for enriching microparticles or nucleic acids using binding molecules: Methods for enriching specific microparticles, such as fetal microparticles or disease specific microparticles, in a biological sample are disclosed. In certain embodiments, the methods include combining a biological sample with a molecule that binds specific microparticles, and separating fractions of the biological sample, wherein the fraction that contains the binding... Agent: Esoterix Genetic Laboratories, LLC
20120196283 - Qualitative and quantitative detection of microbial nucleic acids: The present invention relates to new methods and uses for the qualitative and quantitative detection of microbial nucleic acids using at least a first control nucleic acid, or a first and a second control nucleic acid in different concentrations. The method is based on amplification of nucleic acids, for example... Agent: Roche Molecular Systems, Inc.
20120196287 - Tmsb4 as a biomarker for iga nephropathy: The present invention provides a method for diagnosis or prognosis of IgA nephropathy in a subject based on detection of the expression level of one or more biomarker genes selected from the group consisting of thymosin β4 (Tmsb4), serine or cysteine proteinase inhibitor clade E member 2 (Serpine2), secreted phosphoprotein... Agent: National Defense Medical Center
20120196288 - Chip-based droplet sorting: A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.... Agent: Lawrence Livermore National Security, LLC
20120196291 - Control nucleic acids for multiple parameters: The present invention concerns the amplification of at least a first and a second target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes.... Agent: Roche Molecular System, Inc.
20120196296 - Dna sequencing system: An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection... Agent: Life Technologies Corporation
20120196293 - Method and kit for in vitro diagnosis of atherosclerosis: A method for in vitro diagnosis of atherosclerosis, comprising: (a) obtaining a sample from a subject; (b) determining expression levels of one or more microRNAs (miRNAs) as atherosclerotic biomarkers and an internal control RNA; (c) computing the relative expression levels of the one or more miRNAs as atherosclerotic biomarkers; (d)... Agent: Kaohsiung Medical University
20120196290 - Method for diagnosing spinal muscular atrophy: A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a universal multiplex PCR using the nucleotide as a template and... Agent: Kaohsiung Medical University
20120196289 - Novel assay for detecting immune responses involving antigen specific cytokine and/or antigen specific cytokine secreting t-cells: Here, we describe a sensitive and specific assay and kit for the detection of chemokines having activity that is upregulated by Th-1 cytokines (such IFN-γ) and chemokines that upregulate the activity of Th-1 cytokines (such as IFN-γ). In a typical embodiment, detection of the chemokine monokine induced by gamma interferon... Agent:
20120196292 - Sequence amplification with linear primers: The present disclosure relates to the amplification of target nucleic acid sequences for various sequencing and/or identification techniques. The use of these primers, as described herein, allows for the reduction in the amplification of nonspecific hybridization events (such as primer dimerization) while allowing for the amplification of the target nucleic... Agent: Life Technologies Corporation
20120196295 - Uv excitable fluorescent energy transfer dyes: Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted from the donor dye. One... Agent: Life Technologies Corporation
20120196294 - Workflow for detection of ligands using nucleic acids: This application relates to methods for ligating oligonucleotides having complementarity to a target nucleic acid, and amplifying the ligated oligonucleotides, where ligation and amplification occur in the same reaction mixture.... Agent: Life Technologies Corporation
20120196297 - Mass tags for mass spectrometric analysis of immunoglobulins: The present invention is a method for the characterization or detection of one or more antibodies in a sample. The method comprises obtaining a tagged antigen comprising an antigen and a mass tag attached to the antigen. The tagged antigen has specificity for the antibody. In addition, the method comprises... Agent:
20120196298 - Mitochondrial function of prohibitin 2 (phb2): The present invention relates to a PHB2 gene regulator and a therapeutic drug for mitochondrial-function-related disease containing the same, for example.... Agent: Jichi Medical University
20120196301 - Use of binding partners for 5-ht5 receptors for the treatment of neurodegenerative and neuropsychiatric disorders: The present invention relates to the use of binding partners for 5-HT5 receptors for the treatment of neuropathological, in particular neurodegenerative and/or neuropsychiatric, disorders, which can occur, in particular, in cerebral ischemia, stroke, epilepsy and seizures in general, chronic schizophrenia, other psychotic disorders, dementia, in particular Alzheimer's dementia, demyelinizing disorders,... Agent:
20120196302 - Detecting method: A detecting method is herein disclosed. The method includes steps of providing an eukaryotic cell, having a cell nucleus and a cell membrane, wherein the cell nucleus endogenetically translates a first receptor and a second receptor, and wherein the first receptor and the second receptor pass through the cell nucleus... Agent:
20120196299 - Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto: Methods, assays, and apparatus are disclosed for testing of antigens associated with intestinal and/or blood-brain barrier permeability. For example, blood, saliva or other bodily fluid can be tested for binding (1) to a bacterial toxin (preferably a lipopolysaccharide), and (2) binding to tissue antigens selected from at least one of... Agent:
20120196300 - Neurodegenerative markers for psychiatric conditions: The present invention relates to methods for detecting a psychiatric condition optionally associated with a depression comprising the steps of measuring the concentration of at least one in vivo degradation product of tryptophan. Further, the present invention relates to the use of said values as predictive markers for the detection... Agent: University Of Maastricht
20120196306 - Compositions and methods for the detection of hiv-1/hiv-2 infection: This invention relates to compositions and methods for the detection of immunodeficiency virus infection, especially immunodeficiency virus-1 (HIV-I) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-HIV-1 antibodies.... Agent: The United States Of America
20120196303 - Cybp as a marker for lung cancer: The present invention relates to the assessment of lung cancer. It discloses the use of protein CYBP in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample, derived from an individual by measuring CYBP in said sample. Measurement... Agent:
20120196304 - Detection apparatus: The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides... Agent: Life Technologies Corporation
20120196305 - Detection of a specific dek isoform as a urine-based biomarker for bladder cancer: The present invention is directed to a method of detecting a DEK protein isoform 2 in a human urine sample using ELISA. Methods and compositions for detection of DEK isoform 2 in human urine are provided herein. The presence of DEK isoform 2 in urine is shown to correlate with... Agent: Medical Diagnostic Laboratories, LLC
20120196308 - Methods and kits for measuring von willebrand factor: Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Iba having at least two of a G233V, D235Y and M239V mutations and an agent to detect a complex between the recombinant glycoprotein Iba... Agent:
20120196307 - Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological samples after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain.... Agent: University Of Florida Research Foundation, Inc.
20120196309 - Methods and kits for detection of antibiotic resistance: The present invention relates to a method of detecting antibiotic resistant bacteria in a sample. The method includes the steps of analyzing a sample derived from bacteria via mass spectrometry to produce a data set, and determining from the data set the presence or absence of a covalently modified antibiotic... Agent: Yale University
20120196310 - A-fucosylation detection in antibodies: This invention describes a new analytical method to determine the quantity and distribution of fucose per Fc within an antibody preparation.... Agent:
20120196316 - Analysis of ova or embryos with digital holographic imaging: Method for analyzing a sample comprising at least one ovum or embryo, the method being based on digital holographic imaging, the method comprising the following steps: creating at least one object beam and at least one reference beam of light, where said at least one object beam and said at... Agent: Phase Holographic Imaging Phi Ab
20120196312 - Culture medium for epithelial stem cells and organoids comprising the stem cells: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising the epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem... Agent:
20120196313 - Devices and methods for enhanced cellular sample transfer: Described are embodiments of a biological specimen collection transfer and container system and method for handling and processing specimens of cellular, and related particulate matter, directly into a vial or other like container. The vial, or container, assembly includes a series of ridges, protrusions, or like engagement members, that extend... Agent: Resolution Biomedical, Inc.
20120196318 - Method and assembly for determining cell vitalities: The method includes binding living cells to magnetic particles, adding them to a sensor array, uniformly distributing over the sensor array, magnetically fixing the magnetic particles having the bound cells over the sensor array, and adding substances to maintain and/or improve the cell vitality to the sensory array, and/or adding... Agent:
20120196315 - Methods of developing terpene synthase variants: The present disclosure relates to methods of developing terpene synthase variants through engineered host cells. Particularly, the disclosure provides methods of developing terpene synthase variants with improved in vivo performance that are useful in the commercial production of terpene products. Further encompassed in the present disclosure are superior terpene synthase... Agent: Amyris, Inc.
20120196317 - Portable enrichment, aliquoting, and testing device of microorganisms and toxins: The present invention relates to devices for conducting microorganism or toxin detection. More particularly, the invention relates to portable, pre-packaged devices that are suitable for culturing microorganisms, aliquoting predetermined volumes of testing samples, and conducting microorganism or toxin detection based on immunological reactions using samples of considerable size collected at... Agent: Fundacion Gaiker
20120196314 - Three-dimensional (3d) hydrodynamic focusing using a microfluidic device: A microfluidic device comprises inlets for a sample flow and an out-of-plane focusing sheath flow, and a curved channel section configured to receive the sample flow and out-of-plane focusing sheath and to provide hydrodynamic focusing of the sample flow in an out-of-plane direction, the out-of-plane direction being normal to a... Agent: The Penn State Research Foundation
20120196311 - Using cells reprogrammed with oncogenic factors for screening anti-neoplastic agents: Cells reprogrammed with oncogenic factors (CROFs) include incorrectly programmed stem cells such as induced pluripotent stem cells (iPSCs). The present application discloses linkages between iPS reprogramming and its potential roles in neoplastic transformation and thus establishes a foundation for using iPSCs as a class of CROFs for screening anti-neoplastic agents.... Agent:
20120196319 - Method for activating a self-contained biological indicator: The present invention provides a device for activating a self-contained biological indicator. The biological indicator includes a casing, an ampule having a growth-promoting medium disposed therein and microorganisms. The ampule and microorganisms are disposed within the casing. The device is comprised of a first lever arm having a cavity formed... Agent: American Sterilizer Company
20120196320 - Optical projection tomography microscopy (optm) for large specimen sizes: Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images... Agent:
20120196321 - Selectable markers and related methods: The invention relates to newly identified selectable marker systems, cells for use in a selectable marker system, and methods for using the selectable marker systems.... Agent: Gt Life Sciences, Inc.
20120196323 - Fermentation process: The present invention relates to a fermentation process for culturing a host cell comprising a vector which comprises an inducible promoter of the mannose operon wherein the inducible promoter of the mannose operon controls expression of a nucleic acid sequence encoding for a polypeptide, in particular the present invention relates... Agent: Lonza Ag
20120196325 - Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor: Carbohydrate utilization-related and multidrug transporter nucleic acids and polypeptides, and fragments and variants thereof, are disclosed in the current invention. In addition, carbohydrate utilization-related and multidrug transporter fusion proteins, antigenic peptides, and anti-carbohydrate utilization-related and anti-multidrug transporter antibodies are encompassed. The invention also provides vectors containing a nucleic acid of... Agent: North Carolina State University
20120196324 - Method for producing an antifungal peptide in a filamentous fungal host cell: The present invention provides a method for producing an antifungal peptide in a filamentous fungal host cell by expressing the antifungal peptide in a host cell which is deficient or partially deficient in the expression of an endogenous glucosylceramide synthase (gcs) gene.... Agent: Novozymes A/s
20120196322 - Protein production: A method for producing from host cells a heterologous polypeptide or protein comprising at least one cysteine residue in a reduced state. The method cultured the host cells in a culture medium comprising a reducing agent; and recovered the heterologous polypeptide or protein comprising at least one cysteine residue in... Agent: Fermentas Uab
20120196326 - Mammalian cell lines for increasing longevity and protein yield from a cell culture: Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene,... Agent: Immunomedics, Inc.
20120196327 - Process for production of protein: The present invention relates to a method for integrating a gene fragment inserted between a pair of transposon sequences into a chromosome of a mammalian cell, comprising introducing at least one expression vector which comprises a gene fragment comprising a DNA encoding a protein of interest and also comprises a... Agent: Inter-university Research Institute Corporation Research Organization Of Information And Systems
20120196328 - Fusion protein mixture for inducing human pluripotent stem cell and preparation method there of: The invention provides the protein mixture including the fusion proteins of C-myc, SOX2, KLF4, OCT-4, wherein each protein comprises a protein transduction domain (PTD) and a small ubiquitin-like modifier (SUMO) fused with the said protein. The invention further provides the preparation method of the protein mixture and its use for... Agent: Novoprotein Scientific (shanghai) Inc.
20120196330 - Isothermal dna amplification: Provided herein are nucleic acid synthesis methods and agents that employ an endonuclease for example, endonuclease V, to introduce a nick into a target DNA including one or more inosine, and uses a DNA polymerase to generate amplicons of the target DNA.... Agent: General Electric Company
20120196329 - Polymerization of nucleic acids using activation by polyphosphorolysis (app) reactions: This disclosure relates to methods of performing activation by polyphosphorolysis (APP) reactions using at least one of the polyphosphorylating agents triphosphate, polyphosphate, imidodiphosphate, thiodiphosphate (or μ-monothiopyrophosphate), and related compounds.... Agent: Life Technologies Corporation
20120196331 - Highly-branched starch, its production and uses: An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-α-maltosyl- and/or 6-α-maltotetraosyl-structure(s) with... Agent: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
20120196333 - Synthesis of statins: The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.... Agent: Lek Pharmaceuticals D.d.
20120196334 - Ligf-type enzymes for bioconversion of lignin-derived compounds: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as... Agent:
20120196335 - Ligf-type transformants for bioconversion of lignin-derived compounds: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as... Agent:
20120196337 - Heterogenous enzymatic catalyst, preparation method, and use: The invention relates to a heterogenous enzymatic catalyst that takes the form of a cellular monolith consisting of a silica or organically modified silica matrix, said monolith including macropores, mesopores, and micropores, said pores being interconnected, and wherein the inner surface of the macropores is functionalized by a coupling agent... Agent:
20120196336 - Radial counterflow reactor with applied radiant energy: An improvement is described for the processing of biological material in a continuous stream by the application of radiant energy taken from the wavelengths from infrared to ultraviolet, and its absorption by a feedstock in a workspace of featuring controlled turbulence created by one or more counter-rotating disk impellers. The... Agent: Mccutchen Co.
20120196338 - Methods and compositions for improving the production of products in microorganisms: Methods and compositions are provided for improving the production of products, such as fuel products like ethanol, in microorganisms. In particular, methods and compositions are described for improving ethanol production utilizing genes identified in Clostridium phytofermentans.... Agent: University Of Massachusetts
20120196339 - Production of industrially relevant compounds in prokaryotic organisms: Disclosed herein are methods for producing compounds (such as 3,4-dihydroxybenzoate, catechol, cis,cis-muconate, or β-carboxy-cis,cis-muconic acid) utilizing biosynthetic pathways in prokaryotic organisms expressing one or more heterologous genes. In some embodiments, the method includes expressing a heterologous asbF gene (for example, a gene having dehydroshikimate dehydratase activity) in a prokaryotic cell... Agent: Los Alamos National Security LLC
20120196340 - Novel sesquiterpene synthase gene and protein: The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene synthase (CVS) which codes for at least one CVS. The invention further provides nucleic acids comprising the nucleotide sequence coding for amino acid residues... Agent:
20120196341 - Fermentive production of four carbon alcohols: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol... Agent: Butamax(tm) Advanced Biofuels LLC
20120196342 - Industrial applications of a novel aldo/keto reductase of zymomonas mobilis: The present invention relates to methods of reducing the toxicity of lignocellulosic hydrolysates which comprise one or more inhibitors. One method reduces the amount of furfural inhibitor leading to a more effective process. Another method reduces the amount of xylitol produced during the fermentation of xylose present in lignocellulosic hydrolysates.... Agent:
20120196344 - Cytoblock preparation system and methods of use: An apparatus and method that may be used for collecting target cells or tissue and preparing a cell block are disclosed.... Agent:
20120196343 - Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same: Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and... Agent: The Curators Of The University Of Missouri
20120196345 - Double coating procedure for the membranes of bioartificial kidneys: The present invention generally relates to modified substrates such as membranes for use in bioartificial organs, such as bioartificial kidneys, and other applications. Certain aspects are generally directed to a membrane or other substrate modified to facilitate the attachment of cells. In one set of embodiments, the substrate or membrane... Agent: Agency For Science, Technology And Research
20120196346 - Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses: The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached to a precursor. The precursors may be virtually any molecule or structure, such as... Agent: Ibc Pharmaceuticals, Inc.
20120196347 - Delta-8 desaturases and their use in making polyunsaturated fatty acids: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) and using these delta-8 desaturases in plants.... Agent:
20120196348 - Large-scale production of soluble hyaluronidase: Provided are methods for preparing culture medium that contains soluble hyaluronidases. The methods employ cells that contain a plurality of active copies of nucleic acid encoding the soluble hyaluronidase and a plurality of feedings and temperature changes, whereby the encoded soluble hyaluronidase is secreted into the cell culture medium.... Agent:
20120196349 - Methods and systems for purifying non-complexed botulinum neurotoxin: Methods and systems for chromatographically purifying a botulinum neurotoxin are provided. These methods and systems allow for efficient purification of a non-complexed form of the botulinum neurotoxin in high purity and yield that can be used as an active ingredient in pharmaceutical preparations.... Agent: Revance Therapeutics, Inc.
20120196350 - Bacterium that can perform complete dechlorination of trichloroethene and the method to dechlorinate soils or ground water contaminated with trichloroethene using the bacterium: The bacterium that can perform complete dechlorination of trichloroethene, and the bacteria consortium containing the bacterium are provided, and the method to dechlorinate soils or ground water contaminated with trichloroethene using the bacterium is also provide.... Agent: Page Science Co., Ltd.
20120196351 - Process for the preparation of talc based formulation for ldpe-degrading bacterial consortia: This invention is a process for the preparation of talc based formulation for LDPE-degrading bacterial consortia. The process comprises preparing an active consortium. The active consortium is divided into four parts in centrifuge tubes. The tubes are spun at 5000 rpm. A supernatant is decanted from the tubes. The tubes... Agent: Department Of Biotechnology Delhi
20120196353 - Ligf-type systems for bioconversion of lignin-derived compounds: The teachings provided herein are generally directed to a method of converting lignin-derived compounds to valuable aromatic chemicals using an enzymatic, bioconversion process. The teachings provide a selection of (i) host cells that are tolerant to the toxic compounds present in lignin fractions; (ii) polypeptides that can be used as... Agent:
20120196352 - Novel lactobacillus plantarum and composition comprising same: The present invention provides Lactobacillus plantarum CJLP133 KCTC 11403BP, a composition for treating intestinal diseases comprising the lactic acid bacteria, and a composition for enhancing immunity comprising the lactic acid bacteria.... Agent:
20120196354 - Analysis device: The analysis device includes a main body, an insertion slot into which a sensor piece is inserted in a manner such that the sensor piece sticks out from the main body in a measurement operation, and a pair of projections spaced apart from each other in a y-direction, with the... Agent: Arkray, Inc.
20120196355 - Sterilization indicator: The disclosed technology relates to a sterilization indicator, including a carrier, the carrier having a first surface and a second surface; a support, the support having a first section and a second section, the carrier overlying the first section of the support, the second surface of the carrier being adhered... Agent: American Sterilizer Company
20120196356 - Combined inspection system including mid-ir vibrational spectroscopy and a fluorescent cytometry facility: This disclosure concerns a cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source configured to deliver light to a cell within the cells in order to induce resonant mid-infrared absorption by one or more analytes of... Agent: 1087 Systems, Inc.
20120196357 - Composting machine: An apparatus for the in-vessel composting of feedstock into nutrient-rich compost comprising means for shredding said input material, said means configured and powered for shredding said feedstock into a particle size no larger than one cubic inch, a vessel having an input port on top of such vessel and a... Agent:
20120196358 - Device for removing cumulus from oocytes: Disclosed herein are devices, methods, and kit of parts adapted for stripping cumulus from a plurality of oocytes contained therein.... Agent:
20120196359 - Poly-n-acetyl glucosamine (pnag/dpnag)-binding peptides and methods of use thereof: The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express... Agent: The Brigham And Women's Hospital, Inc.
20120196360 - Method of efficiently establishing induced pluripotent stem cells: Provided is a method of producing an iPS cell, comprising bringing (a) Oct3/4 or a nucleic acid that encodes the same, (b) Klf4 or a nucleic acid that encodes the same, and (c) Sox2 or a nucleic acid that encodes the same, as well as (d1) L-Myc or a nucleic... Agent: Kyoto University
20120196361 - Mart-1 t cell receptors: T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma.... Agent: California Institute Of Technology
20120196362 - Method for treatment and storage of platelets: Provides are improved methods for storing platelets and compositions that contain stored platelets for use in transfusions. The method entails obtaining a platelet concentrate from blood obtained from an individual and holding the platelet concentrate in at refrigerated temperatures under an atmosphere having a pressure of from 3.5 to 5... Agent:
20120196364 - Inhibition of migration and induction of cell death by the type ii collagen amino propeptides: The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an αvβ3 and/or an αvβ5 integrin.... Agent: The Washington University
20120196363 - Method for modulating activity of t lymphocytes: The invention relates to methods and compositions which modulate T lymphocyte activity. It has been found that two, T lymphocyte receptors, especially TCR and CD8, are present at a distance from each other on T lymphocyte surfaces. Via use of modulators which change the distance between these receptors, the activity... Agent: Ludwig Institute For Cancer Research
20120196365 - Differentiation of pluripotent stem cells: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount... Agent:
20120196366 - Method for forming nerve graft: A method for forming a nerve graft includes the following steps. A carbon nanotube structure is provided. A hydrophilic layer is formed on a surface of the carbon nanotube structure. The hydrophilic layer is polarized to form a polar surface on the hydrophilic layer. A number of neurons are formed... Agent: Tsinghua University
20120196368 - Culture medium: A culture medium includes a carbon nanotube structure and a hydrophilic layer. The culture medium is capable of culturing at least one neuron. The hydrophilic layer has a polar surface and is located on a surface of the carbon nanotube structure. The polar surface is located on a surface of... Agent: Tsinghua University
20120196367 - Method for culturing cells on culture medium: A method for culturing a number of cells includes the following steps. A culture medium is provided. The culture medium has a carbon nanotube structure and a hydrophilic layer. The hydrophilic layer is formed on a surface of the carbon nanotube structure. A polar layer is formed on a surface... Agent: Tsinghua University
20120196369 - Method for forming culture medium: A method for forming a culture medium includes the following steps. A carbon nanotube structure is provided. A hydrophilic layer is formed on a surface of the carbon nanotube structure. The hydrophilic layer is polarized to form a polar surface on the hydrophilic layer. A number of neurons are formed... Agent: Tsinghua University
20120196370 - Methods and compositions for targeted genomic deletion: Disclosed herein are compositions and methods for generating chromosomal translocations and targeted deletions of specific lengths and at specific locations the genome of cell.... Agent:
20120196371 - Multi plasmids system for the production of influenza virus: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken... Agent: Medimmune, LLC
20120196372 - Methods for reducing gluconoylation of proteins: The present invention relates to methods of preventing glyconoylation of polypeptides produced in micororganisms.... Agent:Previous industry: Education and demonstration
Next industry: Chemistry: analytical and immunological testing
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