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Chemistry: molecular biology and microbiology July category listing 07/12

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
07/26/2012 > 114 patent applications in 61 patent subcategories. category listing

20120190003 - Organ arrest, protection, preservation and recovery: The present invention relates to a composition for controlling viability of a tissue including a potassium channel opener or adenosine receptor agonist, a compound for inducing local anaesthesia and a compound for reducing the uptake of water by a cell in the tissue. The present invention also relates to the... Agent: Global Cardiac Solutions Pty Ltd.

20120190004 - Methods and compositions for the cryopreservation of duckweed: The present invention describes methods for the cryopreservation of duckweed plants and duckweed plant tissues. The methods comprise freezing a dehydrated duckweed frond colony to a cryopreservative temperature to obtain a frozen frond colony comprising at least one cryopreserved duckweed plant or a cryopreserved duckweed plant tissue. The method can... Agent: Biolex Therapeutics, Inc.

20120190005 - Method for a rational cell culturing process: Biopharmaceutical process development with recombinant protein producing mammalian cells has realized a tremendous increase in both productivity and product yields in the past years. These achievements can be mainly attributed to the advancements in cell line development, media, and process optimization. Only recently, genome-scale technologies enable a system-level analysis to... Agent: Boehringer Ingelheim International Gmbh

20120190011 - Compositions and methods for mammalian genetics and uses thereof: The invention provides compositions and methods for performing mammalian cell genetics, e.g., genetic screens, using near-haploid cells. The invention further provides genes and gene products isolated using the inventive methods and methods of use thereof.... Agent:

20120190010 - Generic matrix for control nucleic acids: The present invention belongs to the field of in-vitro diagnostics. Within this field, it particularly concerns the amplification of at least a first target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes and at least... Agent: Roche Molecular Systems, Inc.

20120190008 - Generic pcr: The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.... Agent: Roche Molecular Systems, Inc.

20120190007 - Method and system for monitoring and recording a viral infection process and that for screening vaccines: The present invention relates to a method and system for monitoring and recording a viral infection process and that for screening vaccines, which is characterized by providing a microcantilever detection device, which comprises a microcantilever comprising a contact area having an macromolecular material attached thereon; allowing host cell to be... Agent: National Taiwan Ocean University

20120190006 - Optoelectronic detection system: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the... Agent:

20120190009 - Viral modulators and processes thereof: A viral modulator and process thereof. A method may include contacting one or more viral modulators to one or more biological systems. A biological system may be configured to be infected by one or more virus. A virus may include an HIV virus, a VEEV virus and/or the like. A... Agent:

20120190012 - Compositions and methods for dna sequencing: The invention provides compositions and methods useful in DNA sequencing. In exemplary embodiments, a detectable label such as a luminescent macrocycle is used.... Agent: Lumiphore, Inc.

20120190013 - Hydrolase enzyme substrates and uses thereof: The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.... Agent:

20120190015 - Method for determining the presence and concentration of analytes using a nucleic acid ligand and rare earth elements: The present invention relates to methods and an apparatus for determining the presence and concentration of an analyte in a sample and the binding of the analyte to a nucleic acid ligand that include measuring the fluorescence emitted by a rare earth element, i.e., terbium, in the presence of the... Agent:

20120190014 - Phage phi 29 dna polymerase chimera: A DNA polymerase chimera comprising an amino-terminal (N-terminal) region encoding a φ29 type DNA polymerase and a carboxyl-terminal (C-terminal) region comprising at least one HhH domain which are bound by means of a connecting amino acid sequence is disclosed along with and the use thereof for replicating, amplifying or sequencing... Agent: Consejo Superior De Investigaciones Cientificas

20120190016 - Compositions for use in identification of salmonella: The present invention relates generally to identification of Salmonella enterica bacteria or strains of Salmonella enterica, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent: Ibis Biosciences, Inc

20120190019 - Concatameric ligation products: compositions methods and kits for same: The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form... Agent: Life Technologies Corporation

20120190020 - Detection of genetic abnormalities: The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA... Agent: Aria Diagnostics, Inc.

20120190021 - Detection of genetic abnormalities: The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA... Agent: Aria Diagnostics, Inc.

20120190030 - Detection of target nucleic acid sequences by cyclic exonucleolytic reactions: The present invention relates to the detection of a target nucleic acid sequence by a cyclic exonucleolytic reaction. The present method enabling to generate signals by probe digestion with no help of primers and to amplify signals with no help of simultaneous target amplification reactions may enable to detect multiple... Agent: Seegene, Inc.

20120190018 - Enhanced risk probabilities using biomolecule estimations: The present invention provides processes for determining more accurate risk probabilities for medical conditions. The risk probabilities of the presence or absence of a medical condition are calculated using frequency data from selected biomolecules and biomolecule source contribution of at least one source in a mixed sample.... Agent: Tandem Diagnostics, Inc.

20120190025 - Enterococcus and fecal bacteroides for rapid water quality assessment: The present invention is drawn to methods and compositions for the rapid assessment of fecal indicator bacteria in a sample. Provided herein are novel primer and probe compositions for use in detecting the presence of these organisms in a sample, particularly using quantitative PCR methods. Provided herein are novel oligonucleotide... Agent:

20120190027 - Ligation-based method of normalized quantification of nucleic acids: The present invention is related to normalized quantification of nucleic acids and to the normalization of quantities of nucleic acids in samples, e.g. mixtures of nucleic acids. The present invention relates to method for the normalization of the quantity of a nucleic acid to be quantified in a sample to... Agent: Qiagen Gmbh

20120190022 - Method for determination of the length of the g-tail sequence and kit for the method: A method of measuring the length of a G tail sequence, characterized by hybridizing the G tail of an nondenatured chromosomal DNA in a sample with a labeled DNA probe having a sequence complementary to the telomere repeat sequence, measuring chemiluminescence from the hybridized DNA probe, and determining the length... Agent: Hiroshima University

20120190024 - Method for determining presence or absence of epithelial cancer-origin cell in biological sample, and molecular marker and kit therefor: The present invention provides a method for determination of presence or absence of an epithelial cancer-derived cell in a biological sample obtained from a subject comprising the steps of: extracting DNA from the biological sample, analyzing methylation status of a CpG site located in at least one region represented by... Agent: Sysmex Corporation

20120190026 - Method of normalized quantification of rna: The present invention is related to normalized quantification of RNAs and to the normalization of quantities of RNAs in samples, e.g. mixtures of RNAs. The present invention relates to method for the normalization of the quantity of a RNA to be quantified in a sample to the total quantity of... Agent: Qiagen Gmbh

20120190029 - Methods for detecting dna originating from different individuals: In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient.... Agent: The Chinese University Of Hong Kong

20120190023 - Methods for distinguishing between natural and artificial dna samples: The present invention provides methods for distinguishing between natural and artificial DNA in samples containing nucleic acid molecules. In addition, the present invention provides methods for verifying that DNA profiles obtained from samples represent natural DNA. In various embodiments, the methods employ an array of nucleic acid based procedures for... Agent: Nucleix

20120190028 - Nucleic acids and methods for the detection of enterobacter sakazakii (cronobacter spp.): Provided are detection means and method specific for the genus Cronobacter (E. sakazakii) which are sensitive by using a target molecule which is multiple existent in Cronobacter cells.... Agent: Biotecon Diagnostics Gmbh

20120190017 - Polymorphisms in the human gene for the multidrug resistance-associated protein 1 (mrp-1) and their use in diagnostic and therapeutic applications: The present invention relates to a polymorphic MRP-1 polynucleotide, genes or vectors comprising the polynucleotides and a host cell genetically engineered with the polynucleotide or gene. Also provided are methods for producing molecular variant polypeptides, cells capable of expressing a molecular variant polypeptide and to a polypeptide encoded by the... Agent:

20120190036 - Clinical method for genotyping large genes for mutations that potentially cause disease: A method of determining polymorphisms within a large gene comprising the steps of: (a) making a Whole-Genome Amplification (WGA) to obtain sufficient amounts of genetic templates for DNA analysis; (b) enriching the WGA sample with nested primers designed for the large gene; (c) using the enriched WGA sample for high... Agent:

20120190035 - Detection of disease related genes: The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing... Agent: The Trustees Of Boston University

20120190032 - Droplet generation for droplet-based assays: A system, including method and apparatus, for generating droplets suitable for droplet-based assays. The disclosed systems may include either one-piece or multi-piece droplet generation components configured to form sample-containing droplets by merging aqueous, sample-containing fluid with a background emulsion fluid such as oil, to form an emulsion of sample-containing droplets... Agent:

20120190033 - Droplet transport system for detection: System, including methods and apparatus, for transporting droplets from a tip to an examination site for detection.... Agent:

20120190031 - Marker for diagnosis of active multiple sclerosis: The invention provides an improved method for monitoring the course of the MS disease and to predict, diagnose or prognosticate whether a subject is in an active or non-active period of MS. The method is based on determining the ratio of the expression levels of two cytokines, measured before and... Agent: Universit&#xc9 Libre De Bruxelles

20120190034 - Optical fiber measurement device and measurement method using same: Disclosed is a highly reliable optical fiber measurement device and measurement method having a simple and compact structure. The device includes a planar liquid holder having a plurality of liquid holding portions arranged along a flat face; a plurality of light receiving optical fibers for transmitting fluorescence generated in the... Agent: Universal Bio Research Co., Ltd.

20120190037 - Device and method for isolating biological or chemical targets: s

20120190038 - Lovd mutants exhibiting improved properties towards simvastatin synthesis: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the disclosure teaches that variants of the LovD acyltransferase polypeptide can be engineered to exhibit properties that facilitate their use in the production of simvastatin and/or huvastatin. The materials and... Agent: The Regents Of The University Of California

20120190040 - Cell concentration, capture and lysis devices and methods of use thereof: The present invention provides a microfluidic devices and methods of use thereof for the concentration and capture of cells. A pulsed non-Faradic electric field is applied relative to a sample under laminar flow, which results to the concentration and capture of charged analyte. Advantageously, pulse timing is selected to avoid... Agent: Qvella Corporation

20120190041 - Methods, immunoassays and devices for detection of anti-lipoidal antibodies: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a solid support (such as a nitrocellulose membrane) is described. The ability to immobilize a... Agent: The Government Of The United States Of America As Represented By The Secretary Of The

20120190039 - Raf dimers and uses thereof: Disclosed herein are mutated RAF and KSR nucleic acids and polypeptides. Also disclosed are methods of using the mutated RAF and KSR to inhibit the dimerization of RAF/RAF and RAF/KSR. Also disclosed are methods of using the mutated RAF and KSR to screen for inhibitors of dimerization.... Agent: Universite De Montreal & Mount Sinai Hospital

20120190048 - Method for determining the binding of a given compound to a membrane receptor: The invention relates to a method for determining whether a test compound binds preferentially to a membrane receptor R1 or to a membrane receptor R2, these receptors being known to be expressed on the surface of the cells in monomeric, homodimeric or heterodimeric form. This method is applied using one... Agent: Cis Bio International

20120190049 - Glypican-3 targeting of liver cancer cells using multifunctional nanoparticles: Method for labeling and detecting liver cancer cells using an anti-glycipan-3 antibody as a targeting agent and a magnetic nanoparticle as an imaging agent.... Agent: University Of Washington Through Its Center For Commercialization

20120190043 - Enzymatic substrates for multiple detection systems: An inventive substrate is provided which includes a substrate compound of formula A-B1-B2-B3-B4: wherein A is a sugar moiety; B1 is a linker moiety allowing the conjugation of moiety A and the remaining structure of the substrate; B2 is a linker moiety with a free reactive amino group so as... Agent: Perkinelmer Health Sciences, Inc.

20120190044 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney... Agent: Astute Medical, Inc.

20120190042 - Protein biomarkers and therapeutic targets for osteoarthritis: The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis. In particular, the invention provides the identity of marker proteins whose expressions are correlated with OA, and/or OA progression. Methods and kits are described for using these protein expression profiles in the... Agent:

20120190045 - Peptide inhibitors of abl kinases: Provided are purified compounds comprising SEQ ID NO:1, where the tyrosine at residue (10) is phosphorylated. Also provided are purified compounds comprising SEQ ID NO:1, where the amino acid sequence of the compound is less than 400 amino acids. Additionally provided are methods of determining whether an agent is a... Agent: New York Blood Center, Inc.

20120190046 - Dek as a urine based biomarker for bladder cancer: The present invention is directed to a method of detecting DEK protein in a urine sample. Methods and compositions are provided herein for detecting and diagnosing bladder cancer by chemical-induced precipitation of urine proteins, followed by filtration-induced concentration and Western blot analysis to specifically detect DEK protein. The present method... Agent: Medical Diagnostic Laboratories, LLC

20120190047 - Levetiracetam immunoassays: Methods, compositions and kits are disclosed directed at levetiracetam derivatives, immunogens, signal generating moieties, antibodies that bind levetiracetam and immunoassays for detection of levetiracetam.... Agent:

20120190050 - Cancer biomarker and the use thereof: Gastric cancer is one of the leading causes of cancer-related death worldwide. To date no specific marker is available for gastric cancer screening. The expression profile of 37 proteins was identified to be consistently different between the plasma of normal and gastric cancer subjects. The expression of complement component C9... Agent: National University Of Singapore

20120190051 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: Disclosed are methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, disclosed are assays that detect one or more markers selected from the group consisting of Prostatic acid phosphatase, Lactotransfenin, Soluble erythropoietin receptor, Von... Agent: Astute Medical, Inc.

20120190052 - Method of determining factor xiii by means of nad(p)h-analogues: The invention is in the field of in-vitro diagnostics and relates to a photometric method for determining the blood-clotting factor XIII (factor XIII, F XIII) with the aid of NAD(P)H analogues, and a test kit for carrying out the method. The invention is in the field of in-vitro diagnostics and... Agent: Siemens Healthcare Diagnostics Products Gmbh

20120190053 - Method of determining factor xiii with the aid of plasma-based reference material: The present invention is in the field of in-vitro diagnostics and relates to a method of determining the blood-clotting factor XIII (factor XIII, F XIII) with the aid of plasma-based reference material, and a test kit for carrying out the method.... Agent: Siemens Healthcare Diagnostics Products Gmbh

20120190054 - Method of analyzing cellulose decay in cellulosic material hydrolysis: Enzymes and/or polypeptides and/or mixtures of interest are evaluated during hydrolysis of cellulosic material by the use of indicator constituents such as fluorescent agents, resulting in efficient high-throughput analysis of enzymes and/or polypeptides. A high-throughput assay for the analysis of inter alia, pretreated corn stover (PCS) hydrolysis is also disclosed.... Agent: Novozymes A/s

20120190056 - Encoded microparticles: The present invention relates to an encoded microparticle for labeling an isolated cell or an isolated embryo characterized in that it is made of a biocompatible material and its external shape comprises a code by which it can be identified. The use of an encoded microparticle for labeling and/or tracking... Agent: Universitat Autonoma De Barcelona

20120190058 - Method for evaluating cell populations: The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods... Agent: Suomen Punainen Risti, Veripalvelu

20120190057 - Method for the qualitative and/or quantitative analysis of tumour cells: A method for qualitative and/or quantitative analysis of tumor cells, including the following steps: a) generating a dye complex from an aminocoumarin and cyclodextrin; b) mixing the tumor cells with the dye complex prepared in step a); c) incubating the cells with the dye complex prepared in step a); d)... Agent: Onkotec Gmbh

20120190059 - Methods for obtaining hepatocytes, hepatic endoderm cells and hepatic progenitor cells by induced differentiation: The present invention discloses a method for inducing the differentiation of embryonic stem cells (ESC) or induced pluripotent stem cells (iPS cells) into hepatocytes, a method for inducing the differentiation of embryonic stem cells or induced pluripotent stem cells into hepatic endoderm cells, and a method for inducing the differentiation... Agent: Beijing Huayuanbochuang Technology Co., Ltd.

20120190055 - Molecule biomarkers of autism: This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present of secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein. The individual metabolites... Agent: Wisconsin Alumni Research Foundation

20120190060 - Microfluidic devices and methods for malaria detection: A device for identifying infection by the malaria parasite includes a microfluidic device having an inlet and an outlet and a diagnostic channel interposed between the inlet and the outlet. The diagnostic channel includes a contact surface and a sample pump configured to pump a RBC-containing sample into the inlet.... Agent: The Regents Of The University Of California

20120190061 - Novel strategy to reduce lactic acid production and control ph in animal cell culture: The present disclosure provides a method for culturing cells in exogenous lactic acid. Certain aspects of the present disclosure include the production of recombinant proteins, such as antibodies and fragments thereof. Certain aspects of the present disclosure also relate to methods of controlling lactic acid production, pH stability and osmolality... Agent: Keck Graduate Institute

20120190062 - Process for the conversion of biomass to liquid fuels and specialty chemicals: A process is disclosed for converting biomass to fuels and/or valuable chemicals. The process comprises the steps of a) activating biomass to make it more susceptible to conversion; c) partially converting the biomass to a solubilized material; and d) subjecting the unconverted biomass to a second conversion step. The process... Agent: Kior Inc.

20120190063 - Rhodanobacter ginsenosidimutans kctc22231t-derived ginsenoside glycosidase, and use thereof: The present invention relates to Rhodanobacter ginsenosidimutans KCTC22231T-derived ginsenoside glycosidase and use thereof, and this protein has an activity of converting PPD (protopanaxadiol)-type saponins into in vivo absorbable, highly active deglycosylated saponins by selective hydrolysis of a bond at a particular position of ginsenoside. More particularly, the present invention relates... Agent:

20120190064 - Feeding buffers, systems, and methods for in vitro synthesis of biomolecules: Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of... Agent: Life Technologies Corporation

20120190066 - host cell for the production of a compound of interest: The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides... Agent: DsmIPAssets B.v.

20120190065 - Combinatorial engineering: The invention concerns the field of cell culture technology. It concerns production host cell lines with increased expression of ribosomal RNA (rRNA) achieved through introduction of nucleic acids encoding UBF or reducing expression of NoRC proteins, especially of TIP-5. Those cell lines have improved secretion and growth characteristics in comparison... Agent: Boehringer Ingelheim International Gmbh

20120190067 - Promoter variants for expressing genes in a fungal cell: The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance, wherein the fungal host cell comprises a first nucleic acid sequence encoding the biological substance operably linked to a second nucleic... Agent: Novozymes, Inc.

20120190068 - Drain down and re-feed of microcarrier bioreactor: Disclosed is a method of increasing product yield per culture in a population of bound product-secreting cells in a bioreactor, the method comprising: semi-harvesting product by removing a volume of the culture medium with a first-secreted product concentration; re-feeding the bound population of product-secreting cells by adding an amount of... Agent: Xcellerex, Inc.

20120190069 - Glutamine-auxothrophic human cells capable of producing proteins and capable of growing in a glutamine-free medium: A glutamine-auxotrophic human cell transfected with an exogenous DNA sequence encoding a protein or an exogenous DNA sequence capable of altering the expression of an endogenous gene encoding a protein and an exogenous DNA sequence encoding a glutamine synthetase, wherein these exogenous DNA sequences are located on one or more... Agent: Lonza Biologics PLC.

20120190070 - Sp35 antibodies and uses thereof: Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such... Agent: Biogen Idec Ma Inc.

20120190071 - Lipa and its variant useful for biofuel production: The present invention relates to LipA and its variant that binds to the glucosyl- and acyl chain- region of its glycoside substrate in plant cell walls useful for biofuel production, wherein presence of a hydrophobic pocket confers extensive hydrophobic interaction of the acyl chain with the rest of the tunnel... Agent: Council Of Scientific & Industrial Research

20120190072 - Protein: The present invention relates to a method for preparing a variant lipolytic enzyme comprising expressing in a host organism a nucleotide sequence which has at least 90% identity with a nucleotide sequence encoding a fungal lipolytic enzyme and comprises at least one modification at a position which corresponds in the... Agent:

20120190073 - Process for large scale production of plasmid dna by e. coli fermentation: The present invention relates generally to a method for increasing the yield of plasmid DNA production. The method includes the steps of selecting a highly productive clonal subtype of a strain of E. coli, including but not limited to the DH5 strain, harboring a DNA plasmid and cultivating said clonal... Agent:

20120190074 - Thermocycler and sample port: The invention relates to continuous flow systems, in particular thermocyclers for the automated and continuous cycling of fluid between a plurality of temperature zones in the amplification of nucleic acids. The invention also relates to an improved sample port for introducing a volume of a liquid sample into a continuous... Agent: Corbett Life Science Pty Ltd

20120190075 - Amylase polypeptides: This invention relates to polypeptides, more specifically amylase polypeptides and nucleic acids encoding these, and their uses e.g. as non-maltogenic exoamylases in producing food or feed products.... Agent:

20120190076 - Recombinant c1 beta-glucosidase for production of sugars from cellulosic biomass: The invention relates to expression of a recombinant C1 β-glucosidase. The invention also provides methods for producing a fermentable sugar from cellobiose by contacting celiobiose with a recombinant host cell comprising a polynucleotide sequence encoding C1 β-glucosidase, operably linked to heterologous promoter, under conditions in which β-glucosidase is expressed and... Agent: Codexis, Inc.

20120190077 - Culture medium and methods for producing alginate from stable mucoid strains of pseudomonas aeruginosa: A specialized culture medium for the promotion of alginate production by stable mucoid Pseudomonas aeruginosa bacterial strains and methods for the production and purification of industrial, commercial, and pharmaceutical grade alginate from bacteriological sources are provided herein. Alginate produced using the media and methods disclosed herein is structurally uniform and... Agent: Progenesis Technologies, LLC

20120190078 - Three-dimensional bioprinting of biosynthetic cellulose (bc) implants and scaffolds for tissue engineering: A novel BC fermentation technique for controlling 3D shape, thickness and architecture of the entangled cellulose nano-fibril network is presented. The resultant nano-cellulose based structures are useful as biomedical implants and devices, are useful for tissue engineering and regenerative medicine, and for health care products. More particularly, embodiments of the... Agent:

20120190079 - Method for racemization of optically active alpha -amino acids: The present invention relates to a method for racemizing an optically active α-amino acid with a viable bacterial cell producing γ-aminobutyric acid aminotransferase or a processed product thereof. According to the present invention, racemic α-amino acids of high quality can be manufactured inexpensively.... Agent: Mitsubishi Gas Chemical Company, Inc.

20120190081 - Microorganism producing o-phosphoserine and method of producing l-cysteine or derivatives thereof from o-phosphoserine using the same: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase... Agent: Cj Cheiljedang Corporation

20120190082 - Microorganism producing o-phosphoserine and method of producing l-cysteine or derivatives thereof from o-phosphoserine using the same: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence... Agent: Cj Cheiljedang Corporation

20120190083 - Microorganism producing o-phosphoserine and method of producing l-cysteine or derivatives thereof from o-phosphoserine using the same: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism... Agent: Cj Cheiljedang Corporation

20120190080 - O-phosphoserine sulfhydrylase mutants and method for production of cysteine using the same: Disclosed is an O-phosphoserine sulfhydrylase (OPSS) mutant which has a Mycobacterium smegmatis-derived amino acid sequence corresponding to that of SEQ ID NO: 1 which is devoid of three to seven C-terminal amino acid residues. Also, a nucleic acid molecule encoding the OPSS mutant, an expression vector carrying the nucleic acid... Agent: Cj Cheiljedang Corporation

20120190084 - Process for the fermentative preparation of sulphur-containing amino acids: Disclosed herein is a process for the fermentative preparation of sulphur-containing amino acids chosen from the group of L-methionine, L-cysteine, L-cystine, L-homocysteine and L-homocystine, comprising the steps: a) provision of a microorganism of the family Enterobacteriaceae or of a microorganism of the family Corynebacteriaceae which has an increased thiosulphate sulphurtransferase... Agent:

20120190085 - Transaminase reactions: The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.... Agent: Codexis, Inc.

20120190086 - Ketoreductase-mediated stereoselective route to alpha chloroalcohols: The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α chloroalcohols from α chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.... Agent: Codexis, Inc.

20120190087 - Preparation of 1,4-diaminobutane: The present invention relates to a novel method for the preparation of 1,4-diaminobutane [DAB]. The method according to the present invention involves at least one biocatalytic step which comprises the biocatalytic production of at least one N-protected precursor of DAB. The present invention also relates to a method for the... Agent:

20120190088 - Method of producing fatty acid alkyl ester using microorganisms having ability to produce oil: The present invention relates to a method of producing a fatty acid alkyl ester using microorganisms having the ability to produce oil, and more particularly to a method of producing a fatty acid alkyl ester, the method comprising culturing microorganisms having the ability to produce oil, thus accumulating a large... Agent: Korea Advanced Institute Of Science And Technology

20120190089 - Engineered microogranisms capable of producing target compounds under anaerobic conditions: The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH... Agent: Gevo, Inc.

20120190090 - Microbial conversion of plant biomass to advanced biofuels: The invention provides consolidated bioprocessing methods and host cells. The host cells are capable of directly converting biomass polymers or sunlight into alcohols or branched-chain hydrocarbons. In particular, the invention provides a method for producing alcohols or branched-chain hydrocarbons from a biomass polymer, including providing a genetically engineered host cell,... Agent: The Regents Of The University Of California

20120190091 - Liquid-phase and vapor-phase dehydration of organic / water solutions: Disclosed herein are processes for removing water from organic compounds, especially polar compounds such as alcohols. The processes include a membrane-based dehydration step, using a membrane that has a dioxole-based polymer selective layer or the like and a hydrophilic selective layer, and can operate even when the stream to be... Agent: Membrane Technology And Research, Inc.

20120190092 - Processes and systems for enzymatically isolating lignin and other bioproducts from herbaceous plants: Methods for enzymatically isolating lignin and other bioproducts, such as fermentable sugars, from herbaceous plant materials, are described. The methods can provide improvements, such as increased product purity and reduced process energy requirements and product modifications and contamination. Systems for practicing the methods also are provided.... Agent: Buckman Laboratories International, Inc.

20120190093 - Method for producing b-glucanase and xylanase using fungus body debris, and liquid culture medium: t

20120190095 - Composition for treatment of neurodegenerative diseases or disorders, method and use comprising electromagnetically irradiated yeast: Provided is a composition which comprises yeast cells treated with, or grown from yeast cells treated with electromagnetic waves in the range of 30 GHz to 300 GHz. Said composition may be used for the treatment of neurodegenerative diseases or disorders. A method relating to the composition is also provided.... Agent: Mb Milmed Ab

20120190094 - Photoreactive regulator of protein function and methods of use thereof: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein... Agent:

20120190097 - Anionic-core composition for delivery of therapeutic agents, and methods of making and using the same: The present invention is directed to compositions comprising a polymer backbone with protective chain and anionic groups, and a cationic therapeutic agent. The present invention is directed to compositions for treating infections, inflammatory diseases, excess growth, and damaged cells and organs.... Agent:

20120190098 - Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems: Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used... Agent: Kent State University

20120190096 - Materials and methods for conjugating a water soluble fatty acid derivative to a protein: The invention relates to materials and methods of conjugating a water soluble fatty acid derivative to a therapeutic protein comprising contacting the therapeutic protein with an activated water soluble fatty acid derivative under conditions that allow conjugation.... Agent: Baxter International Inc.

20120190099 - Methods for enhancing the degradation or conversion of cellulosic material: The present invention relates to methods for degrading or converting a cellulosic material and for producing a substance from a cellulosic material.... Agent: Novozymes, Inc.

20120190100 - Enzymatic composition for the digestion of chicken embryos: The present invention relates to an enzymatic composition for the digestion of chicken embryos intended to the preparation of cells which are used for the production of viruses. The present invention also relates to a method for producing a wild type, an attenuated and/or a recombinant virus comprising a step... Agent: Transgene As

20120190101 - Biological oxidation of hydrogen sulphide in a psychrophilic anaerobic digestion bioreactor subjected to microaerobic conditions: A biological process for removing hydrogen sulphide from biogas is disclosed. The process involves injecting a small quantity of air into the gas phase or the liquid phase of a psychrophilic bioreactor to allow microbial flora to convert the hydrogen sulphide into elemental sulphur.... Agent:

20120190102 - Systems and methods for processing mixed solid waste: Solid waste that includes a mixture of wet organic material and dry organic material can be are separated using mechanical separation to produce a wet organic stream enriched in wet organics and a dry organic stream enriched in dry organics. The separated wet organic stream and dry organic stream are... Agent: Organic Energy Corporation

20120190103 - Device for the treatment of biological fluid: The invention relates to a device (1) for the treatment of a biological fluid, comprising at least three chambers, wherein a first chamber (3), which is provided for receiving the biological fluid, and a second chamber (7), which is provided for receiving a gas, are separated from each other by... Agent: Novalung Gmbh

20120190105 - Cartridge for mems particle sorting system: A disposable cartridge is described which is compatible with a MEMS particle sorting device. The disposable cartridge may include passageways which connect fluid reservoirs in the cartridge with corresponding microfluidic passageways on the MEMS chip. A flexible gasket may prevent leakages and allow the fluid to cross the gasket barrier... Agent: Innovative Micro Technology

20120190104 - Mems particle sorting actuator and method of manufacturing: A MEMS-based system and a method are described for separating a target particle from the remainder of a fluid stream. The system makes use of a unique, microfabricated movable structure formed on a substrate, which moves in a rotary fashion about one or more fixed points, which are all located... Agent: Innovative Micro Technology

20120190106 - Promoter system for regulatable gene expression in mammalian cells: The present invention is directed to a bidirectional human cytomegalovirus (hCMV) promoter that can be used to promote transcription on both strands of a double stranded DNA molecule. When used as part of a system that includes tet operator and the gene coding for the tet repressor, the promoter can... Agent: The Brigham And Women's Hospital, Inc.

20120190107 - Enhanced protein transduction: Methods of enhanced protein transduction are provided. Aspects of the methods include contacting a cell with a transduction protein, where the transduction protein includes both a protein-of-interest domain and a protein transduction domain, and a nucleic acid transfection agent. Also provided are systems and kits that find use in practicing... Agent:

20120190108 - Neuronal progenitor cells and methods of derivation and purification of neuronal progenitor cells from embryonic stem cells: The invention provides neuronal progenitor cells, populations and cultures of cells, cell compositions and methods of producing neuronal progenitor cells. Neuronal progenitor cells can be prepared from embryonic stem cells, such as human embryonic cells.... Agent:

20120190109 - Process for obtaining myofibroblasts: e

20120190110 - Immunological uses of immunomodulatory compounds for vaccine and anti-infectious disease therapy: Methods of enhancing immune response to an immunogen in a subject are disclosed. Also disclosed are methods of reducing the sensitivity to an allergen in a subject. The methods comprise the administration of an immunomodulatory compound in specific dosing regimens that result in enhanced immune response or reduced sensitivity.... Agent:

20120190111 - Differentiation of pluripotent stem cells: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount... Agent:

20120190112 - Differentiation of pluripotent stem cells: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount... Agent:

20120190113 - Macroporous microcarrier specific to liver cell, preparation method and use thereof: The present invention provides a macroporous microcarrier specific to hepatocytes using silk fibroin and galactosylated chitosan as main raw material, a preparation method thereof, and application for hepatocyte culture under the culture condition of microgravity rotation. The macroporous microcarrier s a sphere prepared from silk fibroin and galactosylated chitosan under... Agent:

20120190114 - Silicon-incorporated diamond-like carbon film, fabrication method thereof, and its use: A silicon-incorporated diamond-like carbon thin film, a fabrication method thereof, and its use are disclosed. The silicon-incorporated diamond-like carbon thin film comprises a chemical bond between carbon and silicon atoms present on a surface of the silicon-incorporated diamond-like carbon thin film comprising silicon incorporated within and on the surface thereof... Agent: Korea Institute Of Science And Technology

20120190115 - Genes for enhanced lipid metabolism for accumulation of lipids: Provided herein are exemplary genes, constructs and methods for the formation of triacylglycerols (TAGs). The exemplary genes include a phosphatic acid phosphohydrolase (PA Hydrolase) gene, a diacylglycerol o-acyltransferase (DAGAT2A) gene, and a phospholipid:diacylglycerol acyltransferase (LROI) gene.... Agent:

20120190116 - Process for chromosomal integration and dna sequence replacement in clostridia: The present invention is related to a new method for replacing or deleting DNA sequences in Clostridia, with high efficiency, easy to perform and applicable at an industrial level. This method is useful to modify several genetic loci in Clostridia in a routine manner. This method is based on a... Agent: Metabolic Explorer

  
07/19/2012 > 92 patent applications in 55 patent subcategories. category listing

20120183944 - Decellularization and recellularization of organs and tissues: The invention provides for methods and materials to decellularize an organ or portion thereof and to recellularize such a decellularized organ or portion thereof to thereby generate an organ or portion thereof.... Agent: Regents Of The Univeristy Of Minnesota

20120183945 - Method, device and fluid for treatment of a heart after harvesting: Method and device for treatment of a heart after harvesting and before transplantation. The device includes a container intended to comprise the heart; a first line for connection to an aorta of the heart; a fluid circuit comprising an oxygenator for oxygenating said fluid and a heater/cooler for regulating the... Agent: Vivoline Medical Ab

20120183946 - Fabrication of microfilters and nanofilters and their applications: Micro- and nanofilters with precision pore sizes and pore layout have applications in many fields including capturing circulating tumor cells and fetal cells in blood, water treatment, pathogen detection in water, etc. Methods to fabricate micro- and nanofilters not using track etching or reactive ion etching are provided, allowing easy... Agent:

20120183947 - Multiple laminar flow-based particle and cellular separation with laser steering: The invention provides a method, apparatus and system for separating cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One exemplary method includes providing a first flow having a plurality of components; providing a second flow; contacting the first flow with the... Agent: Arryx, Inc.

20120183948 - Compounds and methods for detection of enzymes that remove formyl, succinyl, methyl succinyl or myristoyl groups from epsilon-amino lysine moieties: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample... Agent: Enzo Life Sciences, Inc. C/o Enzo Biochem, Inc.

20120183951 - Compositions for use in identification of arenaviruses: The present invention relates generally to the detection and identification of arenaviruses and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent:

20120183952 - Compositions for use in identification of caliciviruses: The present invention relates generally to the detection and identification of caliciviruses and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent:

20120183949 - Method, device, or system using lung sensor for detecting a physiological condition in a vertebrate subject: Devices, systems, and methods are disclosed herein for detecting one or more physiological conditions in lungs of a vertebrate subject. A method is described for administering at least one microparticle to lungs of a vertebrate subject, wherein the at least one microparticle includes one or more markers; wherein the one... Agent: Searete LLC, A Limited Liability Corporation Of The State Of Delaware

20120183950 - Tissue analysis: The present invention provides a method of tissue analysis, disease modelling or drug development comprising the steps of providing a tissue sample comprising cells of at least two different cell types; exposing cells in the tissue sample to an agent ex vivo; exposing the cells to three or more detection... Agent:

20120183955 - Design and construction of bifunctional short hairpin rna: A method for designing a bi-shRNA expression cassette encoding a bi-shRNA comprising: selecting one or more target site sequences; providing a backbone sequence comprising a first and a second stem-loop structure, inserting a first passenger strand and a second passenger strand and providing for synthesis of the bi-shRNA expression cassette.... Agent: Gradalis, Inc.

20120183953 - Genome assembly: The invention generally relates to methods for assembling sequence contigs. In certain embodiments, methods of the invention involve converting sequence contigs into maps, generating a plurality of single molecule restriction maps, aligning single molecule restriction maps to ends of the maps of the sequence contigs, thereby producing extended sequence contigs,... Agent: Opgen, Inc.

20120183954 - Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates: Chemically reactive dyes that are intramolecularly crosslinked with a water-soluble bridge, their bioconjugates and their uses are described. Reactive fluorescent dyes that have a water-soluble bridge are superior to those of conjugates of spectrally non-crosslinked dyes or the dyes that are crosslinked with a hydrophobic bridge. The invention includes reactive... Agent: Becton, Dickinson And Company

20120183956 - Sample handling: The invention provides containers and methods of use for the storage, transportation and preparation of samples, such as DNA samples for analysis. The container is pre-provided with the reagents in sealed chambers. The sample can be introduced and the container manipulated to release the reagents, provide the necessary conditions and... Agent: Forensic Science Service Limited

20120183957 - Systems and methods for measuring translation of target proteins in cells: The present invention relates to systems and methods for measuring the rate of translation of a target protein in cells, which are based on the detection of translation of one or more predetermined codon pairs during synthesis of the target protein. The detection is provided by a FRET signal emitted... Agent: Anima Cell Metrology, Inc.

20120183962 - Crude biological derivatives competent for nucleic acid detection: The invention relates generally to the fields of making biological unit lysates or admixtures of body fluids and of RNA analysis. More specifically, it relates to direct methods for the detection of a specific sequence of RNA in a biological unit, for example a virus, cell or tissue sample, or... Agent: Applied Biosystems, LLC

20120183963 - Determination of fetal aneuploidy by quantification of genomic dna from mixed samples: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a... Agent:

20120183964 - Mammalian cytokine; related reagents: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering Corporation

20120183961 - Method for functional testing of site-specific dna methylation: Methods and kits are provided for testing the functional effect of methylating different cytosine residues or testing patterns of DNA methylation on gene expression. Methods are also provided for site-specific methylation, as well as methylated DNA constructs.... Agent:

20120183960 - Method for identifying e. coli m-17: A method of identifying an M17 strain of E. coli in a human biological sample is provided. The method comprises analyzing products of an amplification reaction using DNA extracted from the human biological sample and a primer pair which amplifies an M17 specific nucleic acid sequence of an M17 nucleic... Agent: Enterologics, Inc.

20120183958 - Methods for predicting fat and lean phenotypes in chickens: The invention provides molecular methods for predicting chickens that are more likely to have a lean phenotype, comprising detecting in samples of genetic material obtained from the chickens for the presence of paired single nucleotide polymorphisms (SNPs) in the beta-defensin 9 (DEFB9) gene.... Agent: University Of Delaware

20120183959 - Selective detection of bordetella species: A process for detecting Bordetella spp. nucleic acid in a biological sample includes producing an amplification product(s) by amplifying one or more Bordetella spp. in a multiplex single chamber PCR assay, and measuring said amplification product(s) to detect or distinguish Bordetella spp. in the biological sample. Also provided are reagents... Agent:

20120183966 - Detection and quantitation of insulin receptor alpha isoform or beta isoform: Provided are methods and materials for quantitatively detecting the insulin receptor alpha isoform and the insulin receptor beta isoform.... Agent:

20120183968 - Fluorometer with low heat-generating light source: This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a... Agent:

20120183969 - Immunodiversity assessment method and its use: Disclosed is a method for distinguishing the immunorepertoires of normal, healthy individuals from those of individuals who have symptomatic and/or non-symptomatic disease.... Agent:

20120183967 - Method and compositions for detection and enumeration of genetic variations: Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to... Agent: The Johns Hopkins University

20120183971 - Method for producing implantable medical bioprostheses having reduced calcification properties: The application relates to a method for producing a medical bioprosthesis that can be implanted in a patient and comprises substances from animal tissue, said method comprising a step during which a bioprosthesis is positively selected for implantation in the body of said patient when (i) the phenotype in the... Agent:

20120183970 - Non-mass determined base compositions for nucleic acid detection: The present invention provides systems, methods, and compositions for nucleic acid detection based on non-mass determined base compositions. For example, in certain embodiments, base count data for a template nucleic acid is generated using an approach that does not measure molecular mass of the template nucleic acid (e.g., by sequencing... Agent: Ibis Biosciences, Inc.

20120183965 - Nucleic acid detection: e

20120183972 - Dna capable of inducing osteoblast-specific expression, and nucleotide sequence for same: The invention provides nucleotide sequences that function as enhancers and induce osteoblast-specific expression, expression vectors comprising such an enhancer, a promoter, and a gene containing a coding region, as well as screening methods utilizing such expression vectors.... Agent: Nagasaki University

20120183975 - Taste receptors of the t1r family from domestic dog: The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the canine Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino acid sequences of the polypeptides encoded thereby, and antibodies to the... Agent: Monell Chemical Senses Center

20120183976 - Methods of assessing activity of a polysaccharide composition: Methods of assessing polysaccharide preparations lacking substantial anticoagulant activity are provided herein.... Agent:

20120183973 - Biomarker composition for detecting diabetic retinopathy and diagnostic kit therefor: Provided is a biomarker composition for detecting diabetic retinopathy, comprising at least one protein selected from the group consisting of proteins as set forth in SEQ ID NOS: 1 to 169, a method and a kit for diagnosing diabetic retinopathy using the same. The biomarker can provide fundamental information in... Agent: Snu R & Db Foundation

20120183974 - Novel genes related to glutaminyl cyclase: Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl... Agent: Probiodrug Ag

20120183978 - Antibodies to disulfated heparin disaccharide in the diagnosis of neuropathy: Methods aiding in the diagnosis of certain neuropathies are disclosed, in which the titer of antibodies to a disulfated heparin disaccharide is assessed in a test sample from an subject. Also disclosed are apparatus and kits that can be used in the methods of the invention.... Agent: The Washington University

20120183979 - Protein fragments of virb10 and sero-detection of anaplasma phagocytophilum: Disclosed are cloning and expression of a plurality of protein fragments of virB10, a Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum. Such recombinant protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as kits for ELISA is also disclosed.... Agent: Medical Diagnostic Laboratories, L.L.C.

20120183977 - Sample plate systems and methods: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. A method of using the sample plate and a kit comprising the sample plate is also disclosed.... Agent: Dynex Technologies

20120183980 - Kit for amplifying detected signal in immunosensor and method for detecting target antigen using the same: Disclosed is a kit for amplifying detected signal in immunosensor and a method for detecting target antigen using the same according to the present invention, whereby a target antigen can be effectively detected even by a small amount of target antibody to thereby reduce nonspecific detection signal and to detect... Agent: Lg Electronics Inc.

20120183981 - Methoed for detecting circulating cartilage oligomeric matrix protein in the diagnosis and monitoring of cirrhosis: The present invention is in the field of diagnostics, and in particular to the early diagnosis of liver cirrhosis in a patient not known to have liver cancer by detecting and measuring circulating cartilage oligomeric matrix protein (COMP) alone or in conjunction with one or more additional liver cirrhosis biomarkers... Agent: Inova Diagnostics, Inc.

20120183982 - Non-invasive diagnostic method for the evaluation of intestinal lactase deficiency (hypolactasia): The test of the invention comprises the measuring the total amount of xylose in urine and/or its concentration in blood following oral administration of 4-O-β-D-galactopyranosyl-D-xylose (4-GX) to the patient. It is a non-invasive test that is based on the direct evaluation of the global enzyme activity in the whole individual,... Agent: Venter Pharma, S.l.

20120183983 - Polymeric reverse micelles as selective extraction agents and related methods of maldi-ms analysis: Methods for liquid-liquid extraction, as can be effected using polymeric reverse micelles, such methods as can be used in conjunction with various mass spectrometric techniques.... Agent:

20120183984 - Hydrogen peroxide sensors based upon photo-induced electron transfer: The invention provides compounds of formula I F-L-Q (I) where F comprises a fluorophore capable of absorbing energy at an excitation wavelength and, in the absence of a quencher, emitting energy at an emission wavelength, which is different than the excitation wavelength; Q comprises a quencher; L comprises a linker... Agent: Opti Medical Systems

20120183987 - Co-culture bioreactor system: Disclosed herein are bioreactor systems and methods of utilizing said systems.... Agent:

20120183986 - Fluorescent lactone ion indicators and their applications: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations.... Agent:

20120183988 - Intein-based fluorescent bio-circuit for vitamin d detection: This invention is directed to an intein-based vitamin D fluorescent biosensor that accurately and rapidly measures 1α,25-hydroxyvitamin D3. Measurement at picomolar quantities is noted. Particular reference is made to the use of Escherichia coli (E. coli) as a sensor organism, although yeast and mammalian host organisms are also contemplated.... Agent:

20120183989 - Method for culture of hepatocytes: A method for culturing hepatocytes, wherein hepatocytes embedded in an extracellular matrix is placed on a gas-permeable membrane and the hepatocytes are cultured while being supplied with oxygen from the gas-permeable membrane side. By this, the polarity in the hepatocytes can be induced and a bile canaliculus can be formed... Agent:

20120183985 - Method for the manufacture of microtissues for inducing the growth of a hair follicle: Disclosed is a method for the manufacture of microtissues, comprising the steps of: providing a biomaterial substrate; simultaneously seeding a plurality of dermal papilla (DP) cells and keratinocytes on the substrate surface with a predetermined ratio and cellular density; co-culturing for a predetermined period; and carrying the keratinocytes to the... Agent: National Taiwan University

20120183990 - Microfluidic system and method for producing same: A closed microfluidic system is equipped with a carrier plate and a cover plate as well as wall regions arranged therebetween, which form a system of channels and/or cavities with an inner surface. Selected regions of the inner surface are selectively functionalized.... Agent:

20120183991 - Method for testing drug sensitivity of mycobacterium tuberculosis, application of indicator, and solid medium: A method for testing of drug sensitivity of Mycobacterium tuberculosis. The method includes: pre-treating a specimen, adding a liquid medium to conduct enrichment culturing, heating a solid medium, mixing the specimen after enrichment culturing with the solid medium in a liquid state, cooling, and preparing a solid specimen for testing... Agent:

20120183992 - Reagents and methods for classifying leukocytes: A reagent for classification of leukocytes includes (a) at least two cationic surfactants; (b) at least one organic compound bearing a hydrophobic group and an anionic group; (c) a buffer for adjusting pH into a range of approximately 2-8. Also disclosed is a method for classifying leukocytes with the reagent.... Agent: Shenzhen Mindray Bio-medical Electronics Co., Ltd.

20120183993 - Process for enzymatic hydrolysis of lignocellulosic materila and fermentation of sugars: r

20120183995 - Enhanced protein expression in bacillus: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and... Agent: Danisco US Inc.

20120183994 - Vector for expression of hegf and uses thereof: A vector for expression of hEGF that is made by constructing a gene sequence of SEQ NO: 1 on an expression vector for the transformation of E. coli with said gene sequence to produce hEGF. Through said vector, high purity hEGF can be produced in E. coli and directly excreted... Agent: Ladies Biotechnology Co., Ltd.

20120183996 - Antibody molecules having specificity for human il-6: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.... Agent:

20120183997 - Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.... Agent: Seattle Genetics, Inc.

20120183998 - Modified promoter: The present invention provides a modified promoter, an expression vector and a transformant each containing the promoter, and a method for producing a gene product of interest using the transformant. The invention provides a modified promoter, including a nucleotide sequence of a promoter derived from bacterium belonging to the genus... Agent: Kao Corporation

20120183999 - Use of multiple recombination sites with unique specificity in combinational cloning: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are... Agent: Life Technologies Corporation

20120184000 - Ketoreductase polypeptides for the production of (s,e)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent: Codexis, Inc.

20120184002 - Culturing a microorganism in a medium with an elevated level of a carboxylate counterion source: The invention provides a method of culturing a microorganism that produces a free fatty acid in a culture medium, comprising culturing the microorganism in the culture medium comprising a sufficient amount (e.g., at least about 0.5 mM) of a carboxylate counterion source to enhance viability of the microorganism in the... Agent: Exxonmobil Research And Engineering Company

20120184004 - Methods and compositions for the production of fatty acids in photosynthetic prokaryotic microorganisms: Provided herein are methods and compositions for the production of renewable fatty acids from photosynthetic prokaryotic microorganisms, such as a blue green algae, any specie of the phylum Cyanophyta, a chloroplast of a green algae and/or a Cyanobacterium. Engineered or natural strains of these organisms or organelles can be used... Agent: The Regents Of The University Of California

20120184003 - Production of fatty acids and fatty acid derivatives by recombinant microorganisms expressing polypeptides having lipolytic activity: The invention provides transgenic photosynthetic microorganisms that include non-native genes encoding polypeptides having lipolytic activity for production of free fatty acids and fatty acid derivatives, and methods of producing free fatty acids and fatty acid derivatives using the transgenic microorganisms disclosed herein. The invention also provides transgenic microorganisms that include... Agent: Exxonmobil Research And Engineering Company

20120184001 - Systems and methods for sustainable aquaculture: Provided herein are systems and methods for sustainable aquaculture. The methods provided herein allows recovery and/or recycling of autochthonous nutrients in fish farming, and recovery of allochthonous nutrients present in eutrophic water. The systems provided herein comprises two closely spaced cages, an array of rotary panels that regulates the flow... Agent: Livefuels, Inc.

20120184005 - Bacterial strains and variants thereof that can degrade polylactic acid, and uses of same: The invention relates to strains of bacteria of the genus Ochrobactrum, that can degrade polylactic acid. The invention also relates to an enzyme that can degrade polylactic acid, characterized in that it is produced by said bacteria strains according to the invention. The invention also relates to the applications of... Agent: Universite De Poitiers

20120184006 - Reductase enzymes: In some embodiments, the present invention relates to isolated enzymes useful in reducing a fatty acyl-CoA to a corresponding fatty alcohol in a single biosynthetic step, polynucleotides encoding the enzymes, and methods for making and using these polynucleotides and enzymes. In some embodiments, the invention provides for isolated or recombinant... Agent: Utah State University

20120184007 - Engineered microorganisms with enhanced fermentation activity: Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms.... Agent:

20120184008 - Filamentous fungi and methods for producing trichodiene from lignocellulosic feedstocks: The present invention relates to the production of a C-15 fuel from lignocellulosic or other feedstock. Specifically at least double mutant of filamentous fungi having the isoprenoid pathway results in production of trichodiene in commercial quantities. One embodiment of the invention relates to producing the fuel at the site of... Agent: Novozymes A/s

20120184009 - Continuous culture apparatus with mobile vessel, allowing selection of fitter cell variants and producing a culture in a continuous manner: A method and device for growing plant, animal or stem cells in a continuous manner.... Agent:

20120184010 - Microfluidic device for isolation of cells: A microfluidic system (1) for the isolation of cells (C1) of at least one given type from a sample; the system (1) comprises a separation unit (3), for transferring at least part of the cells (C1) of the given type from a main chamber (4) to a recovery chamber (5)... Agent: Silicon Biosystems S.p.a.

20120184011 - Emulsion compositions: An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality of compartments containing a functional in vitro eukaryotic expression... Agent:

20120184012 - Methods for generation of reporter phages and immobilization of active bacteriophages on a polymer surface: Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of E. coli 0157:H7 to be propagated in nonpathogenic E. coli, thereby eliminating the safety and security risks of propagation in E. coli 0157:H7. Provided are compositions and methods... Agent: Purdue Research Foundation

20120184013 - Inhibitors of bmx non-receptor tyrosine kinase: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.... Agent: Pharmacyclics, Inc.

20120184014 - Photoactive metal nitrosyls for blood pressure regulation and cancer therapy: Disclosed are nitric oxide delivery agents and methods of their use, more specifically to photoactive compounds, which are able to perform targeted delivery of nitric oxide in vitro and in vivo and are useful for medicinal applications including, but not limited, to blood pressure regulation and cancer treatment.... Agent: The Regents Of The University Of California

20120184015 - Cytochrome p450 oxygenases: Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having... Agent: The California Institute Of Technology

20120184016 - Novel protein and gene that codes therefor: The present invention provides a novel protein having neuraminidase activity and/or β-galactoside-α2,6-sialyltransferase activity and a nucleic acid encoding the protein. The present invention further provides a vector containing a nucleic acid encoding the protein, a host cell transformed with the vector, together with a method for producing a recombinant β-galactoside-α2,6-sialyltransferase.... Agent:

20120184017 - Mutant dna polymerases and uses therof: The present invention relates to mutant DNA polymerases which incorporate dideoxynucleotides with about the same efficiency as deoxynucleotides. The present invention also related to mutant DNA polymerases which also have substantially reduced 5′-to-3′ exonuclease activity or 3′-to-5′ exonuclease activity. The invention also relates to DNA molecules coding for the mutant... Agent: Life Technologies Corporation

20120184018 - Genetically programmed expression of selectively sulfated proteins in eubacteria: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods... Agent: The Scripps Research Institute

20120184019 - Stable plasmid expression vector for bacteria: The invention provides compositions and methods for stable plasmid maintenance and protein expression in bacteria. Further provided are compositions and methods for promoting competence in bacteria that are otherwise not transformable.... Agent: The Regents Of The University Of California

20120184020 - Engineered microorganisms with enhanced fermentation activity: Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms.... Agent: Verdezyne, Inc.

20120184021 - Method for effectively controlling harmful organisms in large-scale culture of microalgae: (2) adjusting the pH value of the microalgae culture system according to the different acid and alkali tolerance levels of the harmful organisms; when the harmful organisms are determined to be killed or inhibited effectively, adjusting the pH value back to be suitable for the normal growth of the microalgae.... Agent: Enn Science & Technology Development Co., Ltd.

20120184022 - Convenient system and method of composting: The present invention describes a system and method for convenient composting. The system is comprised of a door within a building that opens to the outdoors. Additionally, the system comprises a chute proximal to the door, or affixed to a portion of the door wherein the chute can transport compostable... Agent:

20120184023 - Method of preparing a glycoside of a mono- or diacylglycerol product from a plant material: The present invention provides a method of preparing a glycoside of a mono- or diacylglycerol product from a plant material. The method comprises the steps of: (i) optionally milling the plant material, (ii) extracting the optionally milled plant material with a first aqueous extraction solution obtaining a first liquid phase... Agent: Hyben Vital Licens Aps

20120184024 - Container and supporting structure for housing an organ: An apparatus intended for evaluation, preservation and perfusion of an organ, such as a lung. The apparatus includes a container with a bottom portion, an insert portion and a lid portion. A pulmonary artery tube is intended to be connected to the lung pulmonary artery and a trachea tube is... Agent: Vivoline Medical Ab

20120184025 - Nucleic acid analyzer: A nucleic acid analyzer includes a nucleic acid purification kit yielding a nucleic acid solution by isolating and purifying nucleic acid from a specimen; a nucleic acid analysis chip having a rotation axis positioned at a center thereof, with reaction containers at an outer portion than the rotation axis, and... Agent:

20120184026 - Integrated processing plants: An integrated plant comprising: (a) one or more lignocellulose processing units producing one or more sugar streams and one or more lignin streams; (b) one or more lignin-processing units processing one or more of said lignin streams into a lignin product; and (c) one or more sugar processing units processing... Agent:

20120184027 - Polymer composition for photobioreactors: A polymer composition having a modified absorption and transmission characteristic particularly suited for photoreactors or photobioreactors made of plastic molded parts and exposed to sunlight or suitable artificial light sources, the polymer selectively comprises the following substances or a combination thereof in addition to the conventional standard additives: an inorganic... Agent: Georg Fischer Deka Gmbh

20120184028 - Micro ivf chamber: A micro IVF chamber that enables rapid filling, hermetic sealing, and custom gas environment control for secure cell extraction, fertilization, culturing, insemination, macro and microscopic content examination, post examination rapid refilling, return to optimal gas levels and pH values, with direct view of cell in conventional microscopes while maintaining culture... Agent:

20120184029 - Polymer coating comprising 2- methoxyethyl acrylate units synthesized by surface-initiated atom transfer radical polymerization: The present invention relates to preparation of a polymer coating comprising or consisting of polymer chains comprising or consisting of units of 2-methoxyethyl acrylate synthesized by Surface-Initiated Atom Transfer Radical Polymerization (SI ATRP) such as ARGET SI ATRP or AGET SI ATRP and uses of said polymer coating.... Agent: Technical University Of Denmark

20120184030 - Methods for establishing symbioses: The present invention relates to methods for establishing a symbiosis, including the following steps: selecting an organism or an organelle to constitute the symbiont and an organism to constitute the host, the latter not existing naturally in a symbiotic relationship; contacting the symbiont and the host; and maintaining the combination... Agent:

20120184031 - Antisense inhibition via rnase h-independent reduction in mrna: The present invention provides compositions and methods for reducing levels of a preselected mRNA, using antisense compounds targeted to a splice site or a region up to 50 nucleobases upstream of an exon/intron junction on said mRNA. Preferably, said antisense compounds do not elicit RNAse H cleavage of the mRNA.... Agent: Isis Pharmaceuticals, Inc.

20120184032 - Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1−/Pax6+ in the presence of retinoic acid, wherein the cells... Agent: Wisconsin Alumni Research Foundation

20120184033 - container for storing a flowable bodily material, and a method for storing a flowable bodily material: A container (1) for storing stem cell material of an animal for subsequent treatment of the animal contains discrete pouches (15) for the stem cell material. The container (1) comprises a pair of transparent flexible panels (3) which are secured together by a peripheral heat seal (4) to define a... Agent: Fuil Technologies Limited

20120184034 - Specimen preservation chamber and method: The present invention comprises a specimen preserver. A bubble reservoir is used to hold a preserving liquid such as artificial cerebrospinal liquid (aCSF). Oxygen is introduced into the aCSF by a gas diffuser which is attached to the bubble reservoir. The tissue samples are contained in one or more chambers... Agent:

20120184035 - Methods and compositions for reprogramming cells: Methods and compositions are provided for reprogramming cells. In an exemplary embodiment, fibroblasts are reprogrammed to adopt a skeletal, cardiac, or smooth muscle cell fate. Cell and tissue therapies using said methods and compositions are also disclosed.... Agent:

  
07/12/2012 > 95 patent applications in 57 patent subcategories. category listing

20120178075 - Emulsion and mold-releasing agent using the same: Disclosed is an emulsion formed using, as an emulsifier, 0.01 to 30 parts by weight of a perfluoroalkylethyl phosphonic acid salt represented by the general formula: CnF2n+1CH2CH2P(O)(OM1)(OM2) [III] (M1: a hydrogen atom, ammonium salt, or organic amine salt, M2: an ammonium salt or organic amine salt, n: 1 to 6),... Agent: Unimatec Co., Ltd.

20120178076 - Magnetic resonance and non-magnetic resonance analysis: In one embodiment, a hypothermic pulsatile perfusion (HPP) apparatus is described. The example HPP includes a chamber configured to house an object (e.g., kidney, liver, heart, skin graft) to be transplanted. The example HPP may include a nuclear magnetic resonance (NMR) element(s) (e.g., coil) configured to facilitate performing a first... Agent:

20120178077 - Thermal calibration: The present invention relates to the use of one or more amplicons as temperature calibrators. In some embodiments, the calibrators may be used to calibrate the temperature of a microfluidic channel in which amplification and/or melt analysis is performed. In some embodiments, the amplicons may be genomic, ultra conserved elements... Agent: Canon U.s. Life Sciences, Inc.

20120178079 - Human bocavirus and methods of diagnosis and treatment: Human parvovirus, genus Bocavirus, associated with respiratory tract infections in children. Nucleic acid and polypeptide sequences of the virus. Methods and products for diagnosing past or present infection of bocavirus in an individual e.g., by serology testing. Viral nucleic acid, polypeptide and/or viral particles for generating immune response in an... Agent: Karolinska Institutet Innovations Ab

20120178078 - Methods and compositions for nucleic acid detection: The present application relates to Multicomponent Nucleic Acid Enzymes (MNAzymes), which may be used for detecting, identifying and/or quantifying targets. More particularly, this application provides methods of designing and making more reliable MNAzymes, as well as compositions comprising MNAzyme components and methods of using MNAzymes.... Agent: Qiagen Gaithersburg, Inc.

20120178080 - 1,2,4-oxadiazole benzoic acid compositions and their use in bioassays: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.... Agent:

20120178087 - Genotyping assay to predict gamma glutamyl hydrolase (ggh) activity: Single nucleotide polymorphisms (SNPs) in the gene encoding gamma glutamyl hydrolase (GGH) associated with reduced GGH activity are disclosed. The primary SNP is a change from a cytosine to a thymine at a position corresponding to nucleotide 511 of Genbank sequence accession no. NM 003878. Methods and kits for detecting... Agent: St. Jude Children's Research Hospital, Inc.

20120178084 - Integrated active flux microfluidic devices and methods: The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g.,... Agent: California Institute Of Technology

20120178085 - Method for evaluation of cultured cells, and method for screening of biomarker: Disclosed are novel means by which evaluation of cultured cells and screening of biomarkers can be attained without consuming the cultured cells. A method for evaluating cultured cells according to the present invention comprises culturing cells in a serum-free medium, and measuring at least one nucleic acid released from the... Agent:

20120178082 - Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer: The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of having or developing aggressive prostate cancer.... Agent: Wake Forest University Health Sciences

20120178081 - Methods of labeling cells, labeled cells, and uses thereof: Methods of detecting nucleic acids, proteins and cells including methods of detecting two or more nucleic acids, proteins and cells in multiplex bDNA assays, are provided. Assays may be conducted at least in vitro, in vivo, in cellulo, and in situ. Nucleic acids are detected, through cooperative hybridization that results... Agent: Affymetrix. Inc.

20120178086 - Reductive release probes containing a chemoselectively cleavable alpha-azidoether linker and methods of use thereof: Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20120178083 - Specific marker lmx1a on dopaminergic neurons: The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for... Agent: Eisai R&d Management Co., Ltd.

20120178088 - The tumor suppressor killin: The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies.... Agent:

20120178091 - Assay cartridges and methods of using the same: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods... Agent: Meso Scale Technologies, LLC

20120178095 - Cardiomyocyte differentiation: This invention provides a method for testing a factor for cardiogenicity which comprises differentiating human embryonic stem (hES) cells to cardiomyocytes in the presence and absence of the factor wherein the human embryonic stem (hES) cells are cultured under a serum free condition comprising co-culture in the presence of END-2... Agent: Es Cell International Pte Ltd

20120178089 - Materials and methods for the identification of drug-resistant cancers and treatment of same: Disclosed herein are diagnostic methods for identifying cancer and predicting drug resistance. The assays involve the detection of NEK2 gene expression alone or in combination with other genes or clinical factors. The test is suitable for diagnosing and monitoring treatment of subjects having or suspected of having a neoplastic disease,... Agent:

20120178094 - Method for categorizing circulating tumor cells: The present invention provides method for categorizing circulating tumor cells (CTCs) using various cellular markers and revealing or non-revealing assays which provide beneficial insights for clinical staging and therapy decision making in cancer patients.... Agent:

20120178090 - Method for isolating nucleic acids and protein from a single sample: The present invention comprises a method of isolating nucleic acid and protein from the same sample with solid supports, wherein nucleic acid and protein components contained in the sample become bound to distinct solid supports. The invention also allows for kits for isolating nucleic acid and protein from the same... Agent: Invitrogen Dynal As

20120178092 - Method for the replication, amplification or sequencing of a dna template: Methods for replicating, amplifying or sequencing a deoxyribonucleic acid with a φ29 type DNA polymerase are disclosed, along with kits for carrying out the methods.... Agent: Consejo Superior De Investigaciones Cientificas

20120178093 - Methods of assessing a risk of cancer progression: Methods and kits that use miRNA expression to predict the development of brain metastases in non-small cell lung cancer patients are disclosed.... Agent: The Translational Genomics Research Institute

20120178096 - Method for isolating weakly interacting molecules from a fluidic sample: Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred... Agent: Wisconsin Alumni Research Foundation

20120178099 - Highly fluorescent carbon nanoparticles and methods of preparing the same: Highly fluorescent carbon nanoparticles (FCNs), with tunable emission colours of particle size between 1-10 nm also stable in solid form with high quantum yield (>5%) and its method of synthesis thereof yielding said carbon nanoparticles in milligram to gram scale in high synthesis yield (>80%). The present invention also provides... Agent: Indian Association For The Cultivation Of Science

20120178097 - Methods and design of membrane filters: The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design... Agent: California Institute Of Technology

20120178098 - Whole blood assay for measuring ampk activation: A method of sample analysis is provided. In certain embodiments, the method comprises: a) labeling cells of a blood sample using an antibody that specifically binds to phospho-AMPK or a phosphorylated target thereof, to produce a labeled sample; and b) measuring antibody binding by a population of blood cells of... Agent:

20120178103 - Detection of dysplastic or neoplastic cells using anti-mcm6 antibodies: Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the preinitiation complex of DNA replication in tissue, cells or fluid. Target polypeptides include CDC6, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Test samples include tissue of... Agent: Cancer Research Technology Limited

20120178104 - Spatial biomarker of disease and detection of spatial organization of cellular receptors: A signature of a condition of a live cell is established in an assay that allows distribution of the receptors on the cell surface in response to binding a ligand. The receptors can be optically detected and quantified to provide a value for the condition, Test drugs can be screened... Agent: The Regents Of The University Of California

20120178101 - Device, method, and system for quantitatively measuring a specimen using a camera: The present invention relates to a device and method for quantitatively measuring an analyte using a camera. More particularly, to capture the identification code required for obtaining an accurate analysis result for the analyte to be analyzed, to capture the result of the reaction of the analyte using a camera... Agent: Infopia Co., Ltd.

20120178100 - Serum markers predicting clinical response to anti-tnf alpha antibodies in patients with psoriatic arthritis: The invention provides tools for management of patients diagnosed with psoriatic arthritis, specifically, prior to the initiation of therapy with an anti-TNFα agent. The tools are specific markers and algorithms of predicting response to therapy based on standard clinical primary and secondary endpoints using serum marker concentrations. In one embodiment... Agent: Centocor Ortho Biotech Inc.

20120178102 - Characterization of granulocytic ehrlichia and methods of use: The present invention relates, in general, to granulocytic ehrlichia (GE) proteins. In particular, the present invention relates to nucleic acid molecules coding for GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins; purified GE S2, S7, S22, S23, C6.1, C6.2, S1, E8, E46#1, and E46#2 proteins... Agent: Antigenics Inc.

20120178106 - Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof: The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human EGFR. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such... Agent:

20120178105 - Detection of globotriaosylceramide (glc) in human urine samples using an antibody sandwich: Applicant has developed an assay for the detection of GL3 in human samples using a sandwich based immunoassay in which utilizes a pair of GL3 specific monoclonal antibodies, one for capture and one for detection, to create an antibody “sandwich” around the GL3 ligand. To further increase sensitivity, Applicant has... Agent: Genzyme Corporation

20120178109 - Diagnosis of a parasitic disease such as leishmaniasis using ribosomal protein extract (rpe): The invention relates to a diagnosis method for Leishmaniasis using a RPE.... Agent:

20120178107 - Human antibodies that bind human tnfalpha: Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTNFα activity in vitro and in... Agent: Abbott Biotechnology Ltd.

20120178108 - Immunodetectability: In the present disclosure, there is provided a method for improving the immunodetectability of at least one protein in an optionally diluted sample of blood, serum or plasma, comprising a step of heating the sample to a temperature of 64-85° C. prior to a contact between the sample and at... Agent: Atlas Antibodies Ab

20120178111 - Methods and compositions for the detection of lung cancers: A method of screening for, diagnosing or detecting lung cancer in a subject, the method comprising: a) determining a level of a biomarker or a plurality of biomarkers in a sample from the subject, wherein the biomarker(s) is/are selected from the biomarkers listed in Table 8, and b) comparing the... Agent:

20120178110 - Screening of protein candidates: Successful application of an engineered protein as therapeutics or in other industries would require the protein to have good expression level, good biophysical properties and often desired affinity to its target. The present invention provides a method of screening large numbers of protein candidates (PCs) in all three aspects simultaneously.... Agent: National Research Council Canada

20120178112 - Method of detecting skeletal muscle damage: The present invention relates to a method of detecting skeletal muscle damage and to the use of certain proteins and fragments thereof as biological markers (commonly known as “biomarkers”) for such damage. The present invention has particular reference to the detection of muscle toxicity in mammals, particularly humans.... Agent: Biowisdom Ltd.

20120178113 - Detection of igfbp-4 fragments as a diagnostic method: The present invention relates to a method for diagnosing a cardiovascular or cancer disease by detecting IGFBP-4 (Insulin-like Growth Factor Binding Protein-4) fragments in a patient sample. Antibodies specifically recognizing novel epitopes originated by enzyme-dependent cleavage of IGFBP-4 are also disclosed.... Agent: Hytest Ltd.

20120178114 - Methods and devices for detecting thrombin generation: Methods and devices for detecting thrombin generation are disclosed. Generally, the methods include combining a blood sample with a reagent composition so that reaction of the reagent composition and thrombin, if present in the sample, produces a detectable signal; and detecting the detectable signal. Generally, the devices include a fluid-tight... Agent: Mayo Foundation For Medical Education And Research

20120178115 - Mutants of pyrroloquinoline quinine-dependent soluble glucose dehydrogenase: t

20120178116 - Polypeptides for identifying fungicidally active compounds: The invention relates to a combination of polypeptides from phytopathogenic fungi having the biological activity of an aurora kinase and the function of an aurora kinase activator, to nucleic acids coding therefore, to the use of the polypeptides and nucleic acids for identifying modulators of an aurora kinase, to processes... Agent:

20120178117 - Method of lipid assay and reagent for use therein: A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy... Agent: Daiichi Pure Chemicals Co., Ltd.

20120178118 - Biomarkers for monitoring treatment of neuropsychiatric diseases: Methods for identifying and measuring pharmacodynamic biomarkers of neuropsychiatric disease, and for monitoring a subject's response to treatment.... Agent:

20120178122 - Apparatus and method for analyzing bacteria: An apparatus for analyzing bacteria is described that includes an analytic sample preparation section for preparing an analytic sample by treating a specimen so as to generate a morphological difference between Gram-negative bacteria and Gram-positive bacteria, a detector for detecting optical information from each particle contained in the analytic sample... Agent: Sysmex Corporation

20120178119 - Method for measuring autophagy: This invention relates to a method for measuring autophagy in cells, comprising using, as a probe reagent, a single fluorescent protein, to measure a change in fluorescence properties of the fluorescent probe reagent depending on pH changes associated with autophagy, thereby determining the presence or activity of autophagy, wherein the... Agent: Japan Science And Technology Agency

20120178121 - Method to characterize blood and red blood cells via erythrocyte membrane fragility quantification: An apparatus and method for quantifying RBC fragility via stress-induced hemolysis and subsequent optical and computational analysis. While directed toward applications in blood quality control, the technology could have application in diagnosis. The apparatus comprises: a hemolysis unit; an optical analysis unit; and a computation unit. Similarly, the associated process... Agent:

20120178120 - Microplate: The present invention relates to a microplate, or microtitration plate, having an invagination consisting of a continuous peripheral channel making it possible to add thereto, in a single introduction step, a liquid acting as an “evaporation curtain”. The invention is also directed to a device comprising such a microplate, to... Agent: Pierre Fabre Medicament

20120178123 - Enhanced lipid production from algae: A method for stimulating enhanced lipid accumulation by algae includes growing algae in a bioreactor medium including nutrients. The algae have an average lipid content that averages a first % of total cell biomass. A stress inducing environmental condition is initiated that keeps the algae alive, stops cell reproduction, and... Agent:

20120178124 - Sterol side chain-cleaving enzyme protein and use thereof: (2) substrate specificity: when microorganisms that produce the enzyme protein are allowed to react with an aqueous solution containing 100 μg/ml 4-cholesten-3-one or cholesterol at 28° C. for 5 hours, the conversion reaction rate from 4-cholesten-3-one to progesterone is 10% or more, and the conversion rate from cholesterol to pregnenolone... Agent: Mitsubishi Chemical Corporation

20120178125 - Mutant strain of aspergillus sojae with enhanced protease activity and preparation method of natural taste enhancer using the same: The present invention relates to a mutant strain of Aspergillus sojae with an enhanced protease activity and a preparation method of a natural taste enhancer using the same. More specifically, the present invention relates to the mutant strain of Aspergillus sojae with an enhanced protease activity is obtained by selecting... Agent: Cj Cheiljedang Corporation

20120178126 - Methods and materials for increasing expression of recombinant polypeptides: The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription... Agent: Xoma Technology Ltd.

20120178127 - Nucleic acid encoding apoptotic anti-ige antibodies: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.... Agent: Genentech, Inc.

20120178128 - Process for producing cysteine and/or glutathione from cystine employing yeast: The invention provides a process for the conversion of cystine to cystein and/or glutathione comprising contacting cystine with a microorganism. The invention also relates to a yeast extract comprising at least 1.8 mg/g cystein and a yeast autolysate comprising at least 1.3 mg/g cystein.... Agent: DsmIPAssets B.v.

20120178129 - Gene synthesis method: The present invention relates to polymerase chain reaction (PCR)-based methods for the one-step synthesis of nucleic acid molecules, wherein the amplification primers used in said methods are designed such that they have two distinct melting temperatures in order to minimize the competition between polymerase cycling assembly (PCA) and polymerase chain... Agent:

20120178130 - Reusable pcr amplification system and method: A DNA amplification device utilizing a polydimethylsiloxane (PDMS) and silicon substrate coated with spin-on glass (SOG) is provided. This PDMS layer is irreversibly bonded to the SOG layer of the silicon substrate using oxygen plasma. The amplification device is an inexpensive, microfluidic device, which can be utilized as a portable... Agent: The Curators Of The University Of Missouri

20120178131 - Tal effector-mediated dna modification: Materials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.... Agent:

20120178132 - Endoglucanases: The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.... Agent: Codexis, Inc.

20120178133 - System for producing l-homophenylalanine and a process for producing l-homophenylalanine: The present invention relates to a system (10) for producing L-homophenylalanine and a process for producing L-homophenylalanine using the system (10). The system (10) and the process include monitoring and controlling of the reaction conditions (e.g., temperature and pH) to desired or predetermined values. The monitoring, adjusting and agitating steps... Agent: University Sains Malayasia

20120178135 - Enhanced production of lipids containing polyenoic fatty acids by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Martek Biosciences Corporation

20120178134 - Enhancement of biomass production by disruption of light energy dissipation pathways: The invention provides a method of producing biomass or at least one biomolecule comprising culturing a photosynthetic microorganism that comprises a disrupted Non-Photochemical Quenching (NPQ) process, and isolating biomass or at least one biomolecule from the culture.... Agent: Exxonmobil Research And Engineering Company

20120178136 - Fermentation process for producing glycolic acid: The present invention relates to a process of fermentation for producing glycolic acid under specific pH conditions with an increase of the pH during fermentation. The invention relates more particularly to a method for producing glycolic acid by fermentation, which comprises culturing a microorganism having glycolic acid producing ability in... Agent: Roquette Freres

20120178137 - Cell-mediated silica sol-gel encapsulation of living cells and tissues: Methods are provided for the encapsulation of living cells with a silica glass layer. The methods comprise adding a sol solution to cells in buffered media, forming a sol-gel layer on the cells and then diluting the media or removing the cells from the media.... Agent: Purdue Research Foundation

20120178139 - Erythrocyte-binding therapeutics: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created... Agent:

20120178138 - Modifications of peptide compositions to increase stability and delivery efficiency: The disclosed invention relates to methods of modifying peptide compositions to increase stability and delivery efficiency. Specifically, the disclosed invention relates to methods to increase the stability and delivery efficiency of protein kinase C (PKC) modulatory peptide compositions. A “therapeutic peptide composition” comprises a “carrier peptide” and a “cargo peptide.”... Agent: Kai Pharmaceuticals, Inc.

20120178140 - Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems: The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.... Agent: Allergan, Inc.

20120178141 - Luciferases and methods for making and using the same: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20120178142 - Ketoreductases and uses thereof: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent: Codexis, Inc.

20120178143 - Alpha/beta hydrolase-fold enzymes: The present invention relates to the identification of novel hydrolases in gram positive microorganisms. The present invention provides amino acid sequences for the hydrolase. The present invention provides host cells which comprise nucleic acid encoding the hydrolase. The present invention also provides cleaning compositions, animal feeds and compositions used to... Agent: Danisco US Inc.

20120178144 - Method of producing cellulase: A method is described for producing cellulase by fermentation wherein the fermentation is conducted using Trichoderma reesei in a medium containing sewage treatment plant sludge. By utilizing sewage sludge, wastewater could be managed effectively. This is an approach which not only reduces environmental pollution, but also produces cellulase effectively. After... Agent:

20120178145 - Virus scaffold for self-assembled, flexible and light lithium battery: A variety of compositions that include a metal oxide, films and batteries comprising one or more of the compositions, and methods of making the same.... Agent: Massachusetts Institute Of Technology

20120178146 - Bacteria capable of degrading multiple petroleum compounds in solution in aqueous effluents and process for treating said effluents: The invention also relates to a process for treating aqueous effluents comprising a complex mixture of substances containing native hydrocarbons of gasolines and additives that are present in gasolines or diesel fuel, in which process said bacteria are grown under aerobic conditions in the presence of a growth substrate containing... Agent: Ifp Energies Nouvelles

20120178147 - Microbial cultures and methods for anaerobic bioremediation: The invention relates to a consortium of microorganisms that can be used to dehalogenate a chemical composition. Methods of use of the same for biomass production and for use of the same in bioremediation are described.... Agent: Arizona Board Of Regents For And On Behalf Of Arizona State University

20120178148 - Detergent composition: A detergent composition comprising; a subtilisin variant having the amino acid sequence set forth in SEQ ID NO 1, and at least one additional ingredient selected from; i) bleaches selected from percarbonates, persulphates and organic peracids, ii) aminocarboxylates, or iii) sulphonated polymers, or iv) organophosphoric acids or salts thereof and... Agent: Reckitt Benckiser N.v.

20120178149 - Method of preparing plant-derived vlps: Methods of preparing plant-derived virus like particles (VLPs) are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized VLPs, producing a protoplast/spheroplast fraction and apoplast fraction from the plant or plant matter, and recovering the apoplast fraction. The apoplast fraction comprises plant-derived VLPs. Alternatively, VLPs may... Agent: Medicago Inc.

20120178150 - System for fluid perfusion of biological matter comprising tissue: System for fluid perfusion of biological matter that includes tissue. According to one embodiment, the system may include a storage container for storing the biological matter, a thermal control device for cooling the contents of the storage container, a gas generator for generating a preserving gas, a fluid conduit coupled... Agent:

20120178151 - Unitary plastic conductivity sensor: A contacting-type conductivity sensor includes an electrically-insulative plastic body and a plurality of electrodes. The plurality of conductive electrodes is disposed in the plastic body. Each electrode is constructed of plastic and fused with the electrically-insulative plastic body. A method of manufacturing the conductivity sensor is provided along with a... Agent:

20120178152 - Medical hand-held device: A medical hand-held device is disclosed comprising a test tape unit that can be inserted into a device housing which comprises a test tape provided with a plurality of analytical test elements which can be wound by means of a spool, and a tape drive comprising an electric motor and... Agent:

20120178154 - Organic material production system using biomass material and method: An organic material production system using biomass material includes: a hydrothermal decomposition apparatus that causes the biomass material and hot compressed water to countercurrently contact with each other and undergo hydrothermal decomposition, so as to separate the lignin component and the hemicellulose component from a biomass solid residue; a cellulose... Agent: Mitsubishi Heavy Industries, Ltd.

20120178153 - Ph sensor integration to single use bioreactor/mixer: A pH sensing bioreaction system is provided. The system includes a bioreaction container having a plastic wall and a pH sensor attached to the plastic wall. The pH sensor includes a sensor body having a flange that is sealingly attached to the plastic wall. The sensor body has a reference... Agent:

20120178155 - Rotating cell seeding module: An apparatus and method is described for seeding cells on a sample or specimen. The cells may be selectively and locally seeded on an upper and lower surface of a planar sample or specimen or on either or both of an interior luminal surface and exterior surface of a hollow... Agent: Tissue Growth Technologies Corporation

20120178156 - Genetic variant of the annexin a5 gene: The present invention relates to a nucleic acid molecule comprising an annexin A5 (ANXA5) gene regulation element which comprises at least one point mutation, corresponding to nucleotide 186 (G to A), 203 (A to C), 229 (T to C), and 276 (G to A) of SEQ ID NO: 2, a... Agent:

20120178157 - Recombinant poxvirus expressing homologous genes inserted into the poxviral genome: The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use... Agent:

20120178158 - Adult animals generated from induced pluripotent cells: The present invention provides methods and compositions for generating and using induced pluripotent stem cells.... Agent: The Scripps Research Institute

20120178160 - Cultivation of primate embryonic stem cells: The invention relates to methods for culturing human embryonic stem cells by culturing the stem cells in an environment essentially free of mammalian fetal serum and in a stem cell culture medium including amino acids, vitamins, salts, minerals, transferrin, insulin, albumin, and a fibroblast growth factor that is supplied from... Agent: Wicell Research Institute, Inc.

20120178161 - Medium and culture of embryonic stem cells: Previous methods for culturing primate pluripotent stem cells have required either fibroblast feeder cells or a medium which was exposed to fibroblast feeder cells to maintain the stem cells in an undifferentiated state. It has now been found that high levels of fibroblast growth factor in a medium together with... Agent: Wisconsin Alumni Research Foundation

20120178159 - Mesenchymal stem cells (msc) expansion methods and materials: The subject invention concerns materials and methods for growing and expanding MSC while maintaining their undifferentiated phenotype, self-renewal ability, and/or multi-lineage potential. In one embodiment, a method of the invention comprises i) seeding freshly isolated MSC on a planar surface or a 3-D scaffold and growing the cells under physiological... Agent: Florida State University Research Foundation, Inc.

20120178162 - Polymer matrices for cell culture: Synthetic cell culture surfaces, including a hydrophobe modified cellulose or an hydroxylated acrylate polymer composition and optionally including a silica source, cell culture coating and cell culture articles incorporating the composition, and methods of making and using the articles for cell culture, as defined herein.... Agent:

20120178163 - Novel tumor necrosis factor receptor homologs and nucleic acids encoding the same: The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptides molecules comprising the polypeptides of the present invention... Agent:

20120178164 - Treating cardiovascular tissue: This document provides methods and materials for treating cardiovascular tissue. For example, stem cells, compositions containing stem cells, methods for obtaining stem cells, compositions for generating stem cells expressing particular markers, and methods for repairing cardiovascular tissue are provided.... Agent: Mayo Foundation For Medical Education And Research, A Minnesota Corporation

20120178165 - Polymeric coatings and methods for forming them: The present invention relates to a controllable polymeric surface coating including a macromolecule, which is covalently bound to the surface of a substrate, the macromolecule including a plurality of polymerisation initiators and a plurality of surface binding groups. Pendant polymers may be grafted from at least some of the polymerisation... Agent: Commonwealth Scientific And Industrial Research Organisation

20120178168 - Method for regulating protein function in cells using synthetic small molecules: Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20120178167 - Methods for transfecting nucleic acid into live cells: The present invention includes methods for transferring a multigenic phenotype to a cell by transfecting, preferably by phototransfection, and locally transfecting a cell or a cellular process with a laser while the cell is bathed in a fluid medium comprising two or more nucleic acids, thereby introducing the nucleic acid... Agent: The Trustees Of The University Of Pennsylvania

20120178166 - Simplified basic media for human pluripotent cell culture: Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS cells from adult individuals under defined, xeno-free conditions are also described.... Agent:

20120178169 - Tal effector-mediated dna modification: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.... Agent:

  
07/05/2012 > 114 patent applications in 66 patent subcategories. category listing

20120171658 - Device and procedure for the manufacture of blood products: The present invention relates to a device and a procedure for the withdrawal, manufacture, storage and transportation of blood products in the widest sense, in particular a closed blood removal, processing and storages system, as well as a system suitable for the administration of medicinal products which are obtained from... Agent: Justus-liebig-universit&#xc4 T Giessen

20120171659 - Particle analyzer and method for analyzing particles: A particle analyzer may include a sampling unit configured to collect samples containing particles; a sample preparing unit configured to prepare different sub-samples; a reaction unit configured to incubate the sub-samples and one or more corresponding reagents respectively and provide them to the injecting unit; an injecting unit configured to... Agent: Shenzhen Mindray Bio-medical Electronics Co., Ltd.

20120171661 - Detection of antigens: The invention discloses a method for detecting at least one antigen, comprising the following steps: providing magnetic beads, which are coated with antibodies specific for at least one antigen to be detected; bringing the magnetic beads in contact with a washing buffer that comprises at least 8% BSA and incubating... Agent: Eads Deutschland Gmbh

20120171660 - Method for screening and purifying enterovirus, method for mass-producing enterovirus, and method for manufacturing enterovirus vaccine: The present invention relates to methods for screening or purifying enteroviruses, a method for mass-producing enteroviruses, and a method for manufacturing an enterovirus vaccine. The method for screening enteroviruses in a sample comprises the following steps: (A) providing a sample and a carrier, wherein monosaccharides such as glucose or galactose... Agent: National Cheng Kung University

20120171664 - Methods and devices for detection of the strain of a pathogen: Provided are methods and devices for determining the strain of a pathogen in a sample.... Agent:

20120171662 - Simplified device for nucleic acid amplification and method for using same: o

20120171663 - System for detection of occult murine cytomegalovirus (mcmv): Methods and compositions for detecting, treating, characterizing, and diagnosing cytomegalovirus in mammals using a nested-PCR methodology using specific predesigned primers are described.... Agent: The Ohio State University

20120171668 - Enhanced deposition of chromogens utilizing pyrimidine analogs: where R1, R2, R3, and R4 are independently selected from aliphatic, aryl, halogen, a heteroatom-containing moiety, and hydrogen; R1 and/or R3 can be bound to R2 to form a fused, aromatic ring system; R5 is selected from a heteroatom-containing moiety; A is selected from, a carbon atom, a heteroatom, other... Agent: Ventana Medical Systems, Inc.

20120171665 - Fluorescent markers and use thereof for labeling specific protein targets: n is an integer ranging from 1 to 5; F is a fluorophore selected from the group consisting of fluorescein, rhodamine, eosin, thionine, safranin, coumarin, methoxycoumarin, dansyl, BODIPY and BODIPY derivatives; and wherein X, Y and L may be positioned in a 1,3,5; 1,2,3; 1,3,4 or in a 3,4,5 configuration... Agent: Universite De Montreal

20120171666 - Rare cell analysis using sample splitting and dna tags: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with... Agent:

20120171667 - Rare cell analysis using sample splitting and dna tags: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with... Agent:

20120171678 - Apparatus for thermal cycling: This invention provides a system for performing PCR, and real time PCR in particular, with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly transfer heat to and from reaction vessels. The system makes use of the reflective properties of the liquid metal... Agent: California Institute Of Technology

20120171669 - Assay and compositions for detection of bacillus anthracis nucleic acid: The invention includes compositions and methods of detection of Bacillus anthracis that use oligonucleotide probes specific for genetic material contained in the pXO1 and pXO2 plasmids in nucleic acid hybridization reactions. Embodiments of the method may include additional probes specific for other gene sequences to distinguish B. anthracis from other... Agent: Gen-probe Incorporated

20120171670 - Bcr-abl1 splice variants and uses thereof: The present invention is based on BCR-ABL1 splice variants which result from insertion and/or truncation of the bcr-abl1 transcript and the finding that these variants provide resistance to kinase domain inhibitors such as imatinib, nilotinib and dasatinib.... Agent: Quest Diagnostics Investments Incorporated

20120171671 - Chk2 polymorphism as a cancer marker: The invention relates to the use of gene modifications in the human gene CHK2 (CHEK2), which encodes the checkpoint kinase 2, for predicting the risk and progression of cancer diseases, for predicting the response to pharmacological or non-pharmacological therapeutic measures for treating cancer diseases, and for predicting undesired effects of... Agent: Universitaet Duisburg-essen

20120171677 - Compensation for spectral crosstalk in multiplex nucleic acid amplification: A method includes performing a nucleic acid amplification of a nucleic acid sample using a detection probe, wherein the nucleic acid amplification occurs over one or more interrogation periods, and, from the nucleic acid amplification, acquiring amplification data that indicates an amount of nucleic acid present for each of the... Agent:

20120171674 - Detection of cells expressing t1r2 taste receptor: Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or the modulation of the specific binding of a compound that specifically binds to a human T1R2 polypeptide. The binding assays may include... Agent:

20120171676 - Highly sensitive rapid isothermal method for the detection of point mutations and snps, a set of primers and a kit therefor: The present invention refers to a method for detecting a point mutations of a nucleotide sequence by an improve- ment of the LAMP (loop amplification mediated polymerization) amplification method, as well as to a set of primers and kit there- for. As a non limitative embodiment, the invention refers to... Agent:

20120171672 - Inflammatory bowel disease prognostics: The methods and systems of the present invention are useful in the diagnosis of inflammatory bowel disease (IBD) and in the prognosis of IBD progression and disease complications. With the present invention, it is possible to predict outcome of disease and patients who will have a particular risk of disease... Agent: Prometheus Laboratories Inc.

20120171675 - Method for isolating nucleic acids: e

20120171673 - Sample analysis method and assay kit used therein: One embodiment is related to a method of analyzing plural samples. The method includes amplifying a plurality of samples using a first primer and second primer, wherein the first primer includes a tag sequence having a sequence different from a sample to one another and wherein a second primer used... Agent:

20120171683 - Analysis of fragmented genomic dna in droplets: Method of analyzing genomic DNA. Genomic DNA including a target may be obtained. The genomic DNA may be fragmented volitionally to produce fragmented DNA. The fragmented DNA may be passed through a droplet generator to generate aqueous droplets containing the fragmented DNA. An assay may be performed on the droplets... Agent:

20120171685 - Buffers for the stable storage of nucleic acids: Provided herein are buffers for the stabilization of nucleic acid molecules. The buffers find particular use for the stabilization of trace amounts of nucleic acid molecules in a variety of environments, including repeated freeze/thaw cycles. For example, in some embodiments, provided herein are compositions comprising tris(hydroxymethyl)aminomethane (Tris), ethylenediaminetetraacetic acid (EDTA),... Agent: Ibis Biosciences, Inc.

20120171684 - Ddao compounds as fluorescent reference standards: o

20120171689 - Fuidi herd management schema: The invention is a herd management schema based upon the inventor's analysis of the natural history of bovine infection due to Mycobacterium avium subspecies paratuberculosis (Map) and related genomic variants and upon the ability of two distinct Map ELISA tests to sequentially or in parallel determine prior and current Map... Agent:

20120171688 - Gene expression markers for colorectal cancer prognosis: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.... Agent:

20120171682 - Method for detecting, identifying and/or quantifying carbon nanotubes: The present invention relates to a method and a kit for detecting, optionally identifying and optionally quantifying at least one carbon nanotube possibly included in a sample, including the steps consisting in: (a) subjecting said sample to conditions enabling the amplification of a nucleotide sequence using primers capable of amplifying... Agent: Commissariat A L'energie Atomique Et Aux Ene Alt

20120171679 - Method for rapid detection and identification of bioagents in epidemiological and forensic investigations: The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.... Agent: Ibis Biosciences, Inc.

20120171686 - Methods for the identification of microrna and their applications in research and human health: The press invention concerns a method for prediction and identification of microRNA precursors (pre-microRNA) and microRNA molecules using data processing programs and databases. The invention also pertains to the isolated form of these pre-microRNAs, microRNA molecules and derived nucleic acids there of. The invention also relates to recombinant vector, host... Agent: Cepheid

20120171681 - Oligonucleotides, methods and kits for detecting and identifying vancomycin-resistant enterococcus: The present invention relates to methods for detecting the presence or absence of vancomycin resistant enterococci (VRE) in a sample using a multiplex polymerase chain reaction (mtx-PCR) assay. Furthermore, the present invention relates to oligonucleotide primers and kits for the detection of VRE.... Agent:

20120171687 - Response prediction in cancer treatment: Methods comprising detecting whether the p53 gene is present in native form on DNA molecules in tumor cells or cell-free tumor DNA in a sample of body fluid or a tissue sample of the tumor patient or whether the p53 gene on said DNA molecules in said tumor cells or... Agent:

20120171680 - Single-molecule pcr for amplification from a single nucleotide strand: A method, apparatus and system for performing single molecule PCR for amplification from single stranded polynucleotides.... Agent:

20120171690 - Transgenic animals for analyzing cyp3a4 cytochrome p450 gene regulation: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position... Agent: The University Of Sydney

20120171691 - Method for monitoring the bisulfite-mediated conversion of dna: The present invention relates to a method for monitoring the progression of the bisulfite-mediated conversion of DNA during DNA methylation analysis. The method is based on the reaction of the enzyme uracil-DNA-glycosylase (UNG) with at least one labeled DNA reporter molecule, the reporter molecule comprising at least one unmethylated cytosine... Agent: Koninklijke Philips Electronics N.v.

20120171692 - Composition for use in identification of bacteria: The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of bacteria by amplification of a segment of bacterial nucleic acid followed by molecular mass analysis.... Agent: Ibis Biosciences, Inc.

20120171693 - Methods for generating novel stabilized proteins: The disclosure provides methods for identifying and producing stabilized chimeric proteins.... Agent: The California Institute Of Technology

20120171694 - Predictive markers and biomarker panels for ovarian cancer: Methods are provided for predicting the presence, subtype and stage of ovarian cancer, as well as for assessing the therapeutic efficacy of a cancer treatment and determining whether a subject potentially is developing cancer. Associated test kits, computer and analytical systems as well as software and diagnostic models are also... Agent: Vermillion, Inc.

20120171695 - Spontaneously contracting fish cell aggregates, use thereof and method for the production thereof: The invention relates to an in vitro method for producing spontaneously contracting fish cell aggregates, to the fish cell aggregates obtained thereby, and to the use thereof, in particular for testing biological active substances and pharmaceuticals. The in vitro method according to the invention for producing contracting fish cell aggregates... Agent: Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

20120171699 - Antibodies for the detection of integrin complexes in ffpe material: The invention relates to antibodies that are capable to bind the extracellular domain of integrin. Another object of the invention concerns the use of said antibodies for detecting integrins in archival formalin fixed paraffin embedded (FFPE) tissue. The invention also relates to methods for preparing monoclonal rabbit antibodies, wherein the... Agent: Merck Patent Gesellschaf Mit Beschrankter Haftung

20120171700 - Cell identifying apparatus and cell identifying method: A cell identifying apparatus includes a capillary through which a sample flow passes, an irradiating unit that irradiates irradiation light, a light receiving unit that receives transmitted light and outputs a transmitted light signal based on the transmitted light, a measuring unit that receives the transmitted light signal output from... Agent: Furukawa Electric Co., Ltd.

20120171701 - Identification of regulatory t cells via the global gene regulator satb1: A method for the identification of regulatory T cells based on the diminished abundance or even absence of the global gene regulator SATB1 in such regulatory T cells. In particular, the invention relates to a method utilizing ligands that specifically bind to SATB1 for identifying regulatory T cells which are... Agent: Becton, Dickinson And Company

20120171696 - Gene defects and mutant alk kinase in human solid tumors: In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated... Agent: Cell Signaling Technology, Inc.

20120171697 - Method of determining inhibitors of coagulation: A homogeneous method of determining inhibitors of proteolytically active coagulation factors (anticoagulants) in a sample, in particular direct thrombin and factor Xa inhibitors, and also a test kit to be used in such a method. Use is made of ligands which bind to the proteolytically active coagulation factor but are... Agent: Siemens Healthcare Diagnostics Products Gmbh

20120171698 - Method and device for rapid parallel microfluidic molecular affinity assays: Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume flowing through a single channel.... Agent: University Of Washington

20120171703 - Imidazo[1,2-alpha]pyrazin-3(7h)-one derivatives bearing a new electron-rich structure: The present invention relates to compound of formula I: and their use as chemiluminescent and/or bioluminescent reagents.... Agent: Universit&#xc1 Degli Studi Di Siena

20120171702 - Quantitative and self-calibrating chemical analysis using paper-based microfluidic systems: A method of determining the concentration of a test fluid sample using a paper-based microfluidic system having a plurality of hydrophilic testing zones, including: a) depositing said test fluid sample on at least one said testing zone; b) depositing a plurality of standard fluid samples or reactives of differing known... Agent: Monash University

20120171705 - Combination of spla2 activity and oxpl/apob cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event: The use of a combination of sPLA2 activity and OxPL/apoB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event or for the monitoring of a cardiovascular disease.... Agent: The Regents Of The University Of California

20120171704 - Elisa for a naturally-occurring soluble truncated form of il-23 receptor: A naturally-occurring soluble truncated IL-23Rα protein (i.e., Δ9 IL-23Rα) is shown to be present in a biological sample and can serve as a diagnostic tool for autoimmune diseases. There is provided an enzyme-linked immunosorbent assay (ELISA) and test kit for the serological detection of the soluble truncated form of IL-23Rα... Agent: Medical Diagnostic Laboratories, LLC

20120171707 - Assay for inhibitors of sumo and sumo-targeted ubiquitin ligase pathway: The present invention provides a method for determining a putative agent that inhibits the SUMO or the SUMO-targeted ubiquitin ligase pathway comprising the steps of contacting mutant MOT1 cells with the putative agent under conditions (1) permitting mutant MOT1 cell growth in the presence of a SUMO or SUMO-targeted ubiquitin... Agent: Albert Einstein College Of Medicine Of Yeshiva University

20120171706 - Glucose measurement using a current source: A blood glucose meter comprises a blood sample test strip, a constant current source, a precision timer, a digital processor and memory, and an analog measurement circuit, e.g., voltage comparator, analog-to-digital converter (ADC), etc., that eliminates the complex analog front end and other related circuits of present technology glucose meters.... Agent: Microchip Technology Incorporated

20120171708 - Modified flavin adenine dinucleotide-dependent glucose dehydrogenase: b

20120171709 - Method for identifying bacteria from the bacillus cereus group: in which the pH of the reaction medium and the time necessary for detecting the PC-PLC substrate hydrolysis reaction carried out are adapted in such a way that said hydrolysis reaction by the bacteria of the Bacillus cereus group is detected before the hydrolysis of the PC-PLC substrate by the... Agent: Biomerieux, Sa

20120171710 - Method for grass species identification: The present invention relates to the use of at least one peptide comprising or consisting of a sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5, for determining the presence of... Agent: Stallergenes S.a.

20120171711 - Novel method for isolating trichinella or other parasites from organic tissue: The present invention relates to a method for the detection of essentially intact encapsulated or non-encapsulated parasites in meat, comprising the maceration of the meat with an alkaline digestion solution which contains a digestive enzyme that is active in an alkaline environment. Further, uses of a serine endopeptidase in a... Agent:

20120171712 - process for realising a device for collecting and transferring samples for molecular biology: A process for realising a device (1) for collecting and transferring samples for molecular biology, the device including at least: a support body (2) having at least a first portion (2a), and a plurality of fibres (6) attached and arranged on the first portion (2a) of the support body (2)... Agent: Copan Italia S.p.a.

20120171716 - Measurement of mitochondrial membrane potential to assess organ dysfunction: The present invention relates to the field of organ transplantation. More specifically, the present invention provides methods for predicting organ function after transplantation. In certain embodiments, the method comprises measuring mitochondrial membrane potential from a biopsy sample from the donor organ. The present invention is also applicable to organ dysfunction... Agent: The Johns Hopkins University

20120171714 - Method and particle analyzer for measuring a low concentration particle sample: A method and particle analyzer for measuring a low concentration particles sample disclosed.... Agent: Shenzhen Mindray Bio-medical Electronics Co., Ltd.

20120171715 - Semiconductor biosensors: The present application relates to semiconductor devices, in particular to a device for monitoring a cell signal such as an electrical signal produced by living cells in response to external stimulation, optionally in real time, comprising (a) at least one discrete area comprising a high electron mobility transistor (HEMT); and... Agent:

20120171713 - Single chip having the chemical sensor and electronics on the same die: A semiconductor die includes a chemical sensor, a digital to analog converter, and microcontroller formed therein. The chemical sensor detects the presence of a chemical and outputs an analog signal to the digital to analog converter. The analog to digital converter converts the analog signal to a digital signal. The... Agent: Stmicroelectronics Pte Ltd.

20120171717 - Method of selecting safe pluripotent stem cells: Provided is a method of selecting highly safe pluripotent stem cells that do not exhibit differentiation resistance, comprising the steps of (1) inducing a pluripotent stem cell to differentiate, (2) culturing the cell under conditions for maintaining undifferentiated state, (3) detecting the generation of an undifferentiated cell by the cultivation,... Agent: Kyoto University

20120171718 - Submerged perfusion bioreactor: A device for biological purposes such as cell culturing, enzymatic reactions or filtering of fluid has a body with first and second surfaces. The body is delimited by a rim and an aperture in the center of the body. The aperture is covered at the first and second surface by... Agent: Aarhus Universitet

20120171719 - Use of saccharomyces cerevisiae suc2 gene in yarrowia lipolytica for sucrose utilization: Disclosed herein are transformed Yarrowia lipolytica comprising an exogenous polynucleotide encoding a polypeptide having sucrose invertase activity. Also disclosed are methods of using the transformed Y. lipolytica.... Agent: E. I. Du Pont De Nemours And Company

20120171720 - Method of making ribosomes: Methods for making in vitro assembled ribosomal subunits and in vitro assembled ribosomes are provided. Methods of transcribing synthetic rRNA and including the synthetic RNA in a synthetic ribosome are provided. Single vessel methods of transcribing synthetic rRNA, forming a synthetic ribosome that includes the synthetic RNA, and allowing the... Agent: President And Fellows Of Harvard College

20120171721 - Host cell protein knock-out cells for production of therapeutic proteins: The present invention relates to methods and means for making Vitamin K-dependent protein compositions which are devoid or substantially devoid of protein contaminants. In particular, methods and means useful for the reduction or elimination of protein contaminants also being Vitamin K-dependent proteins are described.... Agent: Novo Nordisk Health Care Ag

20120171722 - Personalized production of biologics and method for reprogramming somatic cells: The invention provides a method for producing polypeptide protein products and nucleic acid products having reduced levels of antigenicity in an animal being treated with a biologic product. Somatic cells are isolated from an animal, transformed into pluripotent stem cells, transfected with a nucleic acid(s) of interest, and re-differentiated towards... Agent: Avm Biotechnology, LLC

20120171723 - Fgf homologs compositions and uses thereof: The present invention relates to zFGF5 compositions and methods of using the compositions to proliferate chondrocytes and their progenitors, and to induce deposition of cartilage. zFGF5 compositions are disclosed for treating disorders associated with chondrocytes, such as cartilage injuries and defects. In addition, methods for treating neurological disorders, such as... Agent:

20120171724 - High yield suspension cell line, system, and method for making same: A system and method of adapting host cells to suspension cell culture and a suspension cell line produced thereby are disclosed. The method includes the serial replating of substantially undiluted culture cells onto a surface area until cell clumps are visualized and then, upon cell clumping, moving the cells into... Agent:

20120171725 - Amplicon rescue multiplex polymerase chain reaction for amplification of multiple targets: Disclosed is a method for amplifying and detecting polynucleotides which can provide sensitive, specific detection of multiple targets from a clinical specimen within a relatively short time.... Agent:

20120171727 - Novel genome walking method for cloning of unknown dna sequences adjacent to known sequence: A method and a kit for cloning a nucleotide sequence adjacent to a known nucleotide sequence by PCR are disclosed. The method includes 1) preparing a DNA fragment with cohesive ends by cleaving a DNA that contains the known first nucleotide sequence and the second nucleotide sequence adjacent thereto using... Agent: Korea Research Institute Of Bioscience And Biotechnology

20120171728 - Process for amplifying dna using tetratethylene glycol, kit of parts therefor and use thereof: Disclosed is a process for amplifying DNA, a process for preparing and amplifying DNA, a kit of parts for DNA amplification and DNA preparation, and the use thereof, all of which are characterized by the use of tetraethylene glycol. Moreover, the use of tetraethylene glycol in a reaction solution by... Agent: Qiagen Gmbh

20120171726 - Rapid whole genome amplification: The present invention provides compositions and methods for rapidly amplifying target nucleic acid (e.g., using whole genome amplification) that allows small amounts of starting nucleic acid to be employed. In certain embodiments, the methods employ compositions that comprise: phi29 polymerase, exo- Klenow polymerase and/or Klenow polymerase, dNTPs, primers, and a... Agent: Ibis Biosciences, Inc.

20120171729 - Methods for the synthesis of polyadenylic acid: The present invention provides compositions, kits, and methods for synthesizing polyadenylic acid using polynucleotide phosphorylase, adenosine diphosphate, a buffering agent, and a divalent metal cation. In certain embodiments, the adenosine diphosphate is present at a concentration between about 5.0 mM and about 100 mM, and the buffering agent has a... Agent: Ibis Biosciences, Inc.

20120171730 - Method and substances for preparation of n-substituted pyridinium compounds: Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.... Agent: Roche Diagnostics Operations, Inc.

20120171731 - Alpha-amylase blend for starch processing and method of use thereof: The present disclosure relates to an enzyme blend comprising a low pH, thermostable alpha-amylase and a Bacillus licheniformis alpha-amylase. The blend can include at least about 1.0 Liquefon Unit (LU) of the B. licheniformis alpha-amylase for every 5.0 Modified Wohlgemuth Unit (MWU) of the low pH, thermostable alpha-amylase. The enzyme... Agent: Danisco US Inc.

20120171732 - Non-pressurised pre-treatment, enzymatic hydrolysis and fermentation of waste fractions: The present invention relates to a process for production of fermentation products, including bioethanol by non-pressurised pre-treatment, enzymatic hydrolysis and fermentation of waste fractions containing mono- and/or polysaccharides, having a relatively high dry matter content. The process in its entirety, i.e. from non-pressurised pre-treatment over enzymatic hydrolysis and fermentation to... Agent: Renescience

20120171733 - Microalgae fermentation using controlled illumination: Bioreactors and methods for cultivating microalgae are provided herein. The bioreactor and methods include features and modifications to improve heterotrophic growth efficiency by providing a light signal.... Agent: Phycoil Biotechnology International, Inc.

20120171734 - Extraction of extracellular terpenoids from microalgae colonies: The invention provides methods of extracting and quantifying extracellular terpenoid hydrocarbons, e.g., botryococcenes, methylated squalenes, and carotenoids, from terpenoid-producing and secreting green microalgae.... Agent: The Regents Of The University Of California

20120171736 - Powdery lipase preparation and use thereof: The present invention discloses a powdery lipase preparation in which the particles constituting the powdery lipase have 3,000 to 40,000 pores/mm2 on the surface thereof, and each pore has a diameter of 0.5 μm to 6 μm. This powdery lipase preparation was able to improve lipase activity without using a... Agent: The Nisshin Oillio Group, Ltd.

20120171735 - Production of triacylglycerides, fatty acids, and their derivatives: The invention relates to production of triacylglycerols in cells.... Agent: Massachusetts Institute Of Technology

20120171738 - Enzymatically catalyzed method of preparing mono-acylated polyols: The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacyl-glycerol lipase mutants, as for example derived from Candida antarctica lipase B (CALB); a biocatalytic method of enantioselectively preparing an asymmetric mono-acylated polyol, catalyzed by the same enzyme mutants; as well as the use of... Agent: Basf Se

20120171737 - Preparation method of lactate polymers and lactate copolymers using polyhydroxyalkanoate synthase mutants: Mutants of various polyhydroxyalkanoate (PHA) synthases capable of synthesizing a lactate polymer (PLA) and a lactate copolymer (PLA copolymer), and a method of preparing a lactate polymer and a lactate copolymer using the same are provided. More specifically, a mutant of polyhydroxyalkanoate synthase set forth in SEQ ID NO: 2,... Agent: Lg Chem, Ltd

20120171739 - Xylitol producing microorganism introduced with arabinose metabolic pathway and production method of xylitol using the same: The present invention relates to an efficient production method of xylitol by using the xylitol producing microorganism introduced with arabinose metabolic pathway to inhibit the production of arabitol, the byproduct, and instead to use arabinose only for cell metabolism in xylose/arabinose mixed medium. More precisely, to express efficiently L-arabinose isomerase... Agent: Korea Advanced Institute Of Science And Technology

20120171740 - De-fatted soy production process and value added by-products from de-fatted soy flour: An improved process for producing de-fatted soy utilizing a de-fatted soy flour and for producing value added by-products from de-fatted soy flour wherein soybeans are de-hulled and the de-hulled stream ground to a flour consistency. The ground soy flour is mixed with water and other additives to produce a vitamin... Agent:

20120171741 - Renewable xylenes produced from bological c4 and c5 molecules: The present invention is directed to a method for preparing renewable and relatively high purity p-xylene from biomass, and from C5 molecules in particular. For example, biomass treated to provide a fermentation feedstock is fermented with a microorganism capable of producing a C5 alcohol such as 3-methyl-1-butanol, followed by dehydration... Agent: Gevo, Inc.

20120171742 - Method and apparatus for treating fermentable substances: The present invention relates to a method for treating fermentable organic substances, the method comprising the anaerobic fermentation thereof in a fermentation tank (10), and to equipment which is used to mix the fermentation material and is located, at least in part, outside the fermentation tank. In the case of... Agent: Romil Beheer Bv

20120171743 - Thermotolerant actinomadura strain capable of degrading polyesters: A new thermotolerant Actinomadura sp., which is capable of degrading polyesters, is provided. Compositions comprising the species for use in degrading polyesters are also provided. The invention also relates to methods for degrading polyesters by using the strain and the composition.... Agent: Food Industry Research And Development Institute

20120171744 - Materials for magnetizing cells and magnetic manipulation: A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it... Agent: N3d Biosciences, Inc.

20120171745 - Method for selectively damaging and killing tumor cells and apparatus therefor: A method and an apparatus capable of selectively damaging and killing tumor cells includes a step of irradiating tumor cells with a UV pulse flash having continuous emission spectra ranging at least from 230 to 270 nm, outside a living body of a human or a living body of a... Agent: Tokai University Educational System

20120171746 - Method and system for manipulation of cells: The invention is directed to a method for the manipulation of at least one cell, the method comprising the steps of depositing a metal onto the surface of a substrate, placing the at least one cell at or near the surface of the substrate, and irradiating the surface of the... Agent: Gottfried Wilhelm Leibniz Universitat

20120171747 - Signal amplification microspheres, their use in one-step and multi-step analytical amplification procedures and methods for their production: The present invention relates to microspheres comprising protein signal precursor molecules, or a carrier protein bonded to signal precursor molecules, wherein said signal precursor molecules are activatable to generate a detectable signal whilst remaining bonded to the carrier protein. Also disclosed is a method of making such microspheres comprising the... Agent: Supernova Diagnostics, Inc.

20120171748 - Halomonas strain wdg195-related alpha-amylases, and methods of use, thereof: Compositions and methods relating to an alpha-amylase enzyme obtained from Halomonas variabilis WDG195 are described.... Agent:

20120171749 - Methods for monitoring multiple gene expression: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media... Agent: Novozymes A/s

20120171750 - Purification of vaccinia viruses using hydrophobic interaction chromatography: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in... Agent:

20120171751 - Novel microbe, lipid modifying agent, process for producing 2-acyl-lysophospholipid, process for producing diacylglycerol, process for producing ceramide, and method of degumming oil or fat: A new supply source of enzymes useful for modification of phospholipids for example, and a method for producing 2-acyl lysophospholipid, a method for producing monoacylglycerol, and a method for producing ceramide, as well as a new method for degumming fat and oil. A novel microorganism is provided, which belongs to... Agent: Tokyo University Of Marine Science And Technology

20120171752 - Water/carbonate stripping for co2 capture adsorber regeneration and co2 delivery to photoautotrophs: The invention provides systems and methods for the delivery of carbon to photoautotrophs. The invention utilizes low energy regeneration of adsorbent for CO2 capture and provides for effective CO2 loading into liquids useful for photoautotroph growth and/or production of photosynthetic products, such as biofuels, via photoautotrophic culture media. The inventive... Agent: Algenol Biofuels Inc.

20120171753 - System and method for treating materials in pools: System and method are provided for treating materials in a liquid in a pool having a bottom, using at least one of a stirring device, a brushing device and a wiping device, and an automatic moving arrangement configured for moving any of these devices in the pool. The stirring device... Agent: Seambiotic Ltd.

20120171754 - Stabilized enzymatic composition: The invention relates to compositions comprising enzymes and enzyme stabilizing agents. This is achieved by using an enzyme-stabilizing component which comprises a calcium compound with a bidentate ligand and a phenylboronic acid derivative. Enzyme-containing compositions comprising such an enzyme-stabilizing component are advantageously stable in storage.... Agent: Henkel Ag & Co. Kgaa

20120171755 - Fabrication of hollow nanoneedles: e

20120171756 - Systems and devices for isothermal biochemical reactions and/or analysis: An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters,... Agent:

20120171757 - Cartridge and sensor-dispensing instrument: A disposable cartridge adapted to be used with a sensor-dispensing instrument comprises a housing, test sensors, a mechanical mechanism and moveable seals. The housing forms at least one opening therethrough. The test sensors are stacked in the housing. The test sensors are adapted to assist in testing at least one... Agent: Bayer Healthcare LLC

20120171758 - Device for extracting nucleic acid from a sample: The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection... Agent: Cepheid

20120171759 - Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples: The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within... Agent: Handylab, Inc.

20120171760 - Non-invasive sensing of bioprocess parameters: A system and method for measuring at least one bioprocess parameter utilizes a barrier that separates an external sensor from a culture medium. The barrier allows analytes to diffuse in and out of the culture vessel, thereby allowing the bioprocess parameter to be measured non-invasively by the external sensor.... Agent:

20120171761 - Industrialized algae culturing method and system thereof: An industrialized algae culturing method is provided, which comprises the following steps of: placing algae and a culture solution into a pipeline photosynthesis unit for photosynthesis; introducing the photosynthesized algae and the culture solution into a gas intake/venting unit by means of a powered liquid transport unit to remove oxygen... Agent:

20120171763 - Dissociation method and dissociation agent for avidin and biotin derivatives:

20120171764 - Method of cell cultures and device for implementing it: The invention generally provides a cell culture vessel having at least one first zone and at least one second zone, wherein the first zone is a transfer zone for a culture medium which essentially contains no cells and the second zone is a cell culture zone. The invention further includes... Agent:

20120171762 - Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof: The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and... Agent:

20120171765 - Factor vii or viia - like molecules: Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa conjugate are provided.... Agent: Bayer Healthcare LLC

20120171767 - Compositions and methods for growing human embryonic cells: Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic gem (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or... Agent:

20120171766 - Medium composition comprising neuropeptide y for the generation, maintenance, prolonged undifferentiated growth of pluripotent stem cells and method of culturing pluripotent stem cell using the same: The present invention relates to a medium composition comprising neuropeptide Y, effective for proliferation and maintenance of undifferentiated pluripotent stem cells, and a method for culturing undifferentiated pluripotent stem cells using the same. The present invention improves the culture conditions for undifferentiated pluripotent stem cells, and ultimately, the present invention... Agent:

20120171768 - Collagen-based matrices for vessel density and size regulation: Collagen based-matrices and methods of their use are described. More particularly, collagen-based matrices and methods for regulating vessel density and size within collagen-based matrices are described.... Agent: Purdue Research Foundation

20120171769 - Cell attachment coatings and methods: Cell attachment coatings for articles such as implantable medical devices and cell culture vessels are disclosed. The coatings include an intermediate coater layer which includes a sulfonated component that is bonded in the coating by reacted aryl ketone functional groups. The coating also include a second coated layer including an... Agent:

20120171770 - Bioengineered silk protein-based nucleic acid delivery systems: Nucleic acid transfer is achieved using a silk-based delivery system which releases nucleic acids from silk-based complexes. The silk-based complexes, which are composed, for example, of plasmid DNA (pDNA) and recombinant silk containing polycation and specific polypeptides sequences, can show high biocompatibility, high delivery efficiency, cell selectivity and controlled release... Agent: Trustees Of Tufts College

20120171771 - Modified ips cells having a mutant form of a human immunodeficiency virus (hiv) cellular entry gene: Methods and composition for generation of genetically modified induced pluripotent stem cells and hematopoietic cell derived therefrom are provided. For example, in certain aspects those cells comprise a modified gene structure related to HIV cellular entry, such as CCR5 mutants.... Agent: Cellular Dynamics International, Inc.

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