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Chemistry: molecular biology and microbiology June invention type 06/12

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
06/28/2012 > 113 patent applications in 67 patent subcategories. invention type

20120164622 - Method for harvesting and preparing porcine hearts for use in a cardiac surgical simulator: A method is described and disclosed for harvesting and preparing porcine hearts that may be used, among other things, as an improved analog of the human heart in cardiac simulator systems for training surgical personnel for performing beating heart surgery.... Agent: University Of The West Indies, A Regional Institution, Established By Royal Charter

20120164623 - Laminar flow reactor: The present invention describes a laminar flow bioreactor with improved laminar flow lines of fluids. The bioreactor housing defines a chamber adapted to receive a scaffold. An inlet aperture at one end of the chamber is in fluid communication with an outlet aperture at the opposite end of the chamber.... Agent:

20120164628 - Affinity capture of circulating biomarkers: Methods, devices and systems for capturing biomarkers are provided. In particular, methods, compositions, and systems that utilize affinity capture devices comprising a processing chamber, affinity capture agent and porous membrane are provided.... Agent:

20120164629 - Antibodies for oncogenic strains of hpv and methods of their use: The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The... Agent:

20120164626 - Detection of high grade dysplasia in cervical cells: Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to... Agent: Vysis, Inc.

20120164627 - Methods and devices for microfluidic point-of-care immunoassays: Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.... Agent: Micronics, Inc.

20120164625 - Methods for rapid identification of pathogens in humans and animals: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or... Agent: Ibis Biosciences, Inc.

20120164624 - Sers nanotag assays: Methods and systems for the use of Surface Enhanced Raman Scattering nanotags (SERS nanotags) to create homogeneous (no-wash), heterogeneous or sequence detection assay platforms. In certain embodiments the SERS nanotags are used in combination with magnetic particles. Multiplexed assay platforms are also disclosed. In certain embodiments, the assay is useful... Agent: Oxonica, Inc.

20120164631 - Apparatus and method for performing nucleic acid analysis: The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.... Agent: Pacific Biosciences Of California, Inc.

20120164633 - Digital droplet sequencing: The present invention provides systems, devices, methods, kits, and compositions for sorting and analysis of nucleic acid sequences using digital droplet PCR. In particular, provided herein are methods to convert complex samples into a plurality of simplified samples, and sequence analysis thereof.... Agent: Ibis Biosciences, Inc.

20120164635 - Large stoke shift nir dyes: e

20120164636 - Mammalian oocyte development competency granulosa markers and uses thereof: The present invention relates to the competence of oocytes to uterine implantation and development into living individual. The invention more particularly relates to marker that are detected and measured in granulosa cells collected along with the oocytes during oocyte aspiration as it is done in assisted reproduction techniques.... Agent: Universite Laval

20120164634 - Method for separating particles and/or cells having 2 and more surface specificities: The invention describes an easy method for the gentle separation of cells and/or particles from liquids, preferably blood. For that purpose known steps of magnetic separation procedures are combined with capture particle-assisted separating methods.... Agent: Pluriselect Gmbh

20120164630 - Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction: The invention generally relates to methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction. In certain embodiments, methods of the invention involve obtaining a template nucleic acid, incorporating a pair of sequence identifiers into the template, and sequencing the template.... Agent: Good Start Genetics, Inc.

20120164632 - Quantitation of cellular dna and cell numbers using element labeling: Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a... Agent: Dvs Sciences, Inc.

20120164646 - Detection of genetic abnormalities: The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA... Agent:

20120164638 - Digital quantification of dna methylation: Abnormal DNA methylation can be used as a biomarker in cancer patients. For such purposes, it is important to determine precisely the fraction of methylated molecules in an analyzed sample. A technology we term Methyl-BEAMing achieves this goal. Individual bisulfite-treated DNA molecules can be PCR-amplified within aqueous nanocompartments containing beads,... Agent: The Johns Hopkins University

20120164640 - Methods and compositions for correlating genetic markers with sudden cardiac death risk: The present invention provides a method of identifying a subject as having an increased risk of sudden cardiac death or cardiac arrhythmia by detecting in the subject the presence of various polymorphisms associated with an increased risk of sudden cardiac death or cardiac arrhythmia.... Agent: Duke University

20120164641 - Methods and compositions for detecting mutation in the human epidermal growth factor receptor gene: The invention comprises reagents and methods for detecting cancer-causing mutations in the human EGFR gene. Further, a method of detecting the mutations and a method of treatment are disclosed.... Agent: Roche Molecular Systems, Inc.

20120164642 - Methods and materials for identifying nodular fasciitis: This document provides methods and materials involved in detecting gene rearrangements indicative of nodular fasciitis. For example, methods and materials for determining if a mesenchymal neoplasm is nodular fasciitis based at least in part on the detection of a gene rearrangement (e.g. a USP6 or MYH9 rearrangement) are provided.... Agent:

20120164647 - Methods for assessing the susceptibility of a human to diminished health and wellness: The present invention relates to methods for assessing the advisability that a human should employ a compensatory composition comprised of one or more antioxidant ingredients. The methods involve assessing occurrence in the human's genome of a plurality of certain polymorphisms. Methods for determining the composition of preferred compensatory compositions are... Agent:

20120164639 - Methods for detecting low grade inflammation: The present invention relates to methods for detecting the presence of low grade inflammation in a patient.... Agent:

20120164645 - Multiplex amplification and detection: The invention relates to the field of multiplex amplification. In particular, the invention relates to methods for assaying a sample for one or more nucleic acid targets in a single reaction based on the distinct melting temperatures or melting profiles of primers and/or probes. The invention also provides probes and... Agent:

20120164644 - Nmr systems and methods for the rapid detection of analytes: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.... Agent: T2 Biosystems, Inc.

20120164643 - Set of oligonucleotide probes as well as methods and uses thereto: The present disclosure relates to a set of at least 100 single-stranded oligonucleotide probes directed against (or complementary to) portions of a genomic target sequence of interest. The present disclosure also relates to a method of detecting a genomic target sequence of interest using the set of oligonucleotide probes and... Agent: Roche Diagnostics Operations, Inc.

20120164637 - Susceptibility to bone damage: In one aspect, the present invention provides methods for determining susceptibility to bone damage in a subject. In some embodiments, the methods comprise screening for polymorphisms in the MTHFR and collagen Iα1 genes that are associated with susceptibility to bone damage. In some embodiments, the methods comprise screening for elevated... Agent:

20120164654 - Composition for reverse transcription polymerase chain reaction: A composition for a reverse transcription polymerase chain reaction, which comprises a thermostable DNA polymerase, a reverse transcriptase, a dye marker and a specific gravity-increasing agent; and a premix reagent for a one-step RT-PCR, which comprises the composition, is not frozen under usual storage conditions at −20 to −30° C.... Agent: Takara Bio Inc.

20120164655 - Heat flow polymerase chain reaction systems and methods: Methods and systems for polymerase chain reactions (PCR) that are capable of detecting amplified DNA during or after the PCR process. The methods and systems may utilize DSC or DTA analysis techniques.... Agent: Heatflow Technologies, Inc.

20120164648 - Integrated versatile and systems preparation of specimens: The invention of Integrated Versatile and Systems Preparation of Specimens relates an open module technology which integrates synchronously the methods of protection, isolation and alteration of specimens into the “One for All” product or kit. The product or kit comprises a core module without or with Plug-in modules and a... Agent: Bexmart

20120164650 - Method and means to modulate programmed cell death in eukaryotic cells: The invention provides for the use of isolated polynucleotides encoding maize poly (ADP-ribose) polymerase (PARP) proteins to produce eukaryotic cells and organisms, particularly plant cells and plants, with modified programmed cell death. Eukaryotic cells and organisms particularly plant cells and plants, are provided wherein either in at least part of... Agent: Bayer Bioscience N.v.

20120164651 - Methods and compositions for detection of small rnas: Currently, the circularization of small RNAs is broadly regarded as an obstacle in ligation-related assays and explicitly avoided while short lengths of linear RNA targets is broadly recognized as a factor limiting use of conventional primers in PCR-related assays. In contrast, the disclosed invention capitalizes on circularization of small RNA... Agent:

20120164653 - Methods for the diagnosis of multiple sclerosis based on its microrna expression profiling: The invention relates, in general, to a method for the diagnosis of multiple sclerosis based on determining amounts of one or more micro-RNAs correlated with multiple sclerosis in a biological sample from a subject.... Agent:

20120164652 - Quantitating high titer samples by digital pcr: The present invention provides systems, devices, methods, kits, and compositions for nucleic acid analysis using digital PCR. In particular, methods are provided to analyze high titer samples that cannot be divided into a sufficient number of partitions containing zero nucleic acid molecules per partition to allow for Poisson analysis (digital... Agent: Ibis Biosciences, Inc.

20120164649 - System, devices and methods for monitoring and detection of chemical reactions: Systems, devices and methods are described herein that are configured for use in the monitoring and detecting of chemical reactions, such as, for example, the monitoring and detection of Polymerase chain reactions (PCR). For example, the systems and devices described herein can be used for accelerated real-time PCR. A fully... Agent: Instantlabs Medical Diagnostics Corporation

20120164656 - Methods to identify compounds useful for the treatment of proliferative and differentiative disorders: The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases, and transgenic mice, knock-out mice, host-cell expression systems and proteins encoded by the nucleotides of the novel substrate-targeting... Agent:

20120164659 - Human hcv-interacting proteins and methods of use: The present invention generally relates to a method for identifying and cloning nucleic acid molecules encoding a new class of proteins or fragments thereof, capable of interacting with proteins associated with the Human Hepatitis C virus (HCV) and thus being suitable either alone or in complex with the HCV protein... Agent: Nexigen Gmbh

20120164657 - Method of detecting botulinum neurotoxin and antibodies that neutralize botulinum neurotoxin action: A highly sensitive method of analyzing a sample for the presence or activity of botulinum neurotoxin (BoNT) or antibodies specific for botulinum neurotoxin is disclosed. In one embodiment, the method comprises the steps of preparing primary non-human mammalian or avian spinal cord cells, and exposing the cells to a test... Agent:

20120164658 - Transcription factor modulator: The present invention relates to novel agents that are useful for modulating transcription factor activity. In particular, the present invention relates to a transcription factor modulator comprising (i) a pharmaceutically-effective amount of a HLS-5 polypeptide, isoform thereof, functional fragment thereof or pharmaceutical composition thereof or (ii) a compound or composition... Agent:

20120164664 - T1r taste receptors and genes encoding same: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent:

20120164665 - Interleukin-1 alpha antibodies and methods of use: Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.... Agent: Xbiotech, Inc.

20120164666 - Glycoprotein vesicles and their methods of use: Provided are methods of collecting, detecting and altering cells and molecular entities using glycoprotein micelles and vesicles. Glycoprotein vesicles comprising a glycoprotein micelle, at least a monolayer of lectin and/or a monolayer of biologically active glycoproteins are also provided. The invention further provides methods of detecting protein glycosylation using the... Agent: The Mitre Corporation

20120164660 - Method for using a diagnostic agent which includes a calcium binding protein assay reagent and assay method for calcium binding protein: A bovine- or human-derived calcium-binding protein with a prescribed amino acid sequence, a method for its production, and antibodies against the protein and uses thereof.... Agent:

20120164661 - Methods and reagents for signal amplification: The present invention provides reagents containing binding moieties conjugated to dextran moieties, methods of making such reagents, and use of such reagents in a variety of molecular and cellular assays.... Agent: Biocept, Inc.

20120164663 - Methylated arginine metabolites as risk predictors of cardiovascular disease: Methods for using methylated arginine metabolites and the arginine methylation index as markers for cardiovascular disease are described: The methods typically include determining the levels of dimethylarginine and N-monomethylarginine in a biological sample, comparing the levels of dimethylarginine and N-monomethylarginine to obtain an arginine methylation index; comparing the arginine methylation... Agent: The Cleveland Clinic Foundation

20120164662 - Test method on renal diseases: Provided is a test method for the assessment of the necessity of renal biopsy in a subject to be tested, who is suspected of having a renal disease. Specifically provided are a test method for a renal disease, including using urinary podocalyxin and one or more additional markers in combination,... Agent: Niigata University

20120164667 - Method for test on diabetic nephropathy: Provided is a test method for the detection of diabetic nephropathy at an early stage as compared to a conventional method. Specifically provided are: a test method for diabetic nephropathy, including detecting urinary podocalyxin; the test method, further including assessing diabetic nephropathy at least Stage I; a test reagent for... Agent: Niigata University

20120164668 - Ultrasound assisted immunoassay: The invention relates to methods, devices and systems for an enhanced, ultrasound assisted immunoassay (such as a Western blot immunoassay). In particular, there are provided methods, devices and system for the automated and enhanced processing of a membrane having proteins associated therewith, wherein the processing includes the use of ultrasonic... Agent: Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science

20120164669 - Marker panel for left ventricular hypertrophy: The present disclosure relates to methods, compositions, kits and devices for diagnosing, distinguishing and/or facilitating a therapeutic decision in a subject having left ventricular hypertrophy. In some aspects, the methods, compositions, kits and devices disclosed herein allow for diagnosing, distinguishing and/or facilitating a therapeutic decision in a subject having physiological... Agent: Roche Diagnostics Operations, Inc.

20120164670 - Methods and kits for measuring enzyme activity: The invention relates to methods and kits for measuring enzyme activity, including enzymes that produce nicotinamide.... Agent: President And Fellows Of Harvard College

20120164671 - Methods for monitoring immunosuppressant drug levels, renal function, and hepatic function using small volume samples: Systems and methods are provided for monitoring a immunosuppressant drug level and renal function, hepatic function, or a combination thereof in a patient, comprising obtaining a small volume blood sample from the patient; determining the level of at least one immunosuppressant drug in the small volume blood sample and determining... Agent:

20120164672 - High-throughput in vitro translation (cell-lysate based) assay for detecting quorum sensing signals: A cell-lysate extract based assay reagent for detecting quorum sensing signals is generally provided, along with methods of making and using the same. The assay reagent generally includes a cell-lysate extract formed from a biosensor bacterium (e.g., Agrobacterium tumefaciens NTL4 (pCF218)(pCF372)) and a detecting substrate (e.g., an absorbance-based or luminescence-based... Agent: University Of South Carolina

20120164673 - Ptp1b inhibitors: Described herein are agents, including antibodies, antibody fragments, polypeptides and organic small molecules, that bind reversibly inactive PTP1B (designated herein in the alternative as PTP1B-SN or PTP1B-OX) and stabilize it (stabilize PTP1B-OX) in such a manner that they inhibit reactivation of reversibly oxidized, inactive PTP1B by reduction (by reducing agent)... Agent: Cold Spring Harbor Laboratory

20120164674 - Devices and washes for biomarker stabilization: Herein are disclosed compositions, washes, rinses, devices, systems and methods for biomarker stabilization, in part in bodily fluids, as well as methods and formulations for improving the sampling and testing of fluids for biomarkers. Included in the disclosure are exemplary embodiments of rinses or washes containing a stabilizing agent to... Agent:

20120164675 - Methods and kit for protease enzyme assays: A method for testing efficacy of a protease enzyme assay, the method comprising providing an enzyme which acts as a surrogate enzyme control for the protease enzyme; combining the surrogate enzyme control with an assay substrate for the protease enzyme; and determining a change in the assay substrate resulting from... Agent:

20120164679 - Biological microfluidics chip and related methods: A biological microfluidics chip (100) comprising a substrate (102), a microfluidic inlet port (104) defining an opening in a surface of the substrate (102), and a microfluidic outlet port (106) defining an opening in a surface of the substrate (102). The biological microfluidics chip (100) also comprises a plurality of... Agent: Universiteit Leiden

20120164677 - Method and apparatus for viable and nonviable prokaryotic and eukaryotic cell quantitation: A rapid method for the quantitation of various live cell types is described. This new cell fluorescence method correlates with other methods of enumerating cells such as the standard plate count, the methylene blue method and the slide viability technique. The method is particularly useful in several applications such as:... Agent: Genprime, Inc.

20120164678 - Microbial production of natural sweeteners, diterpenoid steviol glycosides: The invention relates to recombinant expression of a steviol or steviol glycosides biosynthetic pathway enzymes in cells and the production of steviol or steviol glycosides.... Agent: Massachusetts Institute Of Technology

20120164676 - Use of diazolidinyl urea for anti-clumping of biological samples: The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices.... Agent: Biocept, Inc.

20120164680 - Asynchronous magnetic bead rotation sensing systems and methods: Described herein are various methods, devices and systems for performing asynchronous magnetic bead rotation (AMBR) to detect and monitor cellular growth and/or behavior. Cluster rotation of magnetic particles for AMBR is descried. In particular, described herein are systems for the parallel analysis of multiple wells of a sample plate. Also... Agent: The Regents Of The University Of Michigan

20120164683 - Buffy coat separator float system and method: A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced... Agent: Battelle Memorial Institute

20120164682 - Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching: A method for analyzing a blood sample residing within an analysis chamber, which sample has one or more first and second constituents, which constituents are different from one another. The method includes the steps of: a) imaging the sample containing the first and second constituents, which sample is mixed with... Agent: Abbott Point Of Care, Inc.

20120164681 - Method for detection or identification of bacteria or bacterial spores: A method and apparatus for detecting bacteria and bacterial spores are disclosed in which a sample is assessed for the presence of bacteria and/or bacterial spores by reference to horizontally polarized fluorescent light.... Agent:

20120164684 - Sample measuring apparatus and sample measuring method: A sample measuring apparatus of measuring a component in a biological sample, comprising: an input section for inputting a sample species of a biological sample; a measurement sample preparation section for preparing a measurement sample by mixing the biological sample with a reagent; a first measurement section; a second measurement... Agent: Sysmex Corporation

20120164685 - Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use: The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compostions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.... Agent: Epitopix, LLC

20120164686 - Yeast promoters: The invention relates to recombinant promoters and expression constructs comprising the promoters that may be used to express a protein of interest in yeast, such as Yarrowia lipolytica.... Agent: Codexis, Inc.

20120164687 - New strain of salmonella enterica s. typhimurium, its use and a method to obtain a therapeutic vaccine vector: The present invention relates to a new bacterial strain of Samonella enterica serovar Typhimurium VNP20009 deposited in the Polish Collection of Microorganisms under access no. B/00024 and its us in the production of a vaccine, especially an anti-cancer vaccine. The present invention also relates to a method of obtaining a... Agent:

20120164688 - High affinity human antibodies to human nerve growth factor: A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or... Agent: Regeneron Pharmaceuticals, Inc.

20120164689 - Method for isolating specific genomic regions: h

20120164692 - Annealing control primer and its uses: The present invention relates to an annealing control primer for improving annealing specificity in nucleic acid amplification and its applications to all fields of nucleic acid amplification-involved technology. The present primer comprises (a) a 3′-end portion having a hybridizing nucleotide sequence substantially complementary to a site on a template nucleic... Agent: Seegene, Inc.

20120164691 - Compositions and methods for producing single-stranded circular dna: The present invention provides methods, kits, and compositions for producing single-stranded circular DNA by PCR. In particular, hairpin primers are provided, and methods of use thereof to produce single-stranded circular DNA molecules.... Agent: Ibis Biosciences, Inc.

20120164690 - Universal reference dye for quantitative amplification: Universal reference dye mixtures for quantitative amplification, and uses thereof, are provided.... Agent: Bio-rad Laboratories, Inc.

20120164693 - Methods of enzymatic discrimination enhancement and surface-bound double-stranded dna: Methods for discriminating between fully complementary hybrids and those that differ by one or more base pairs and libraries of unimolecular, double-stranded oligonucleotides on a solid support. In one embodiment, the present invention provides methods of using nuclease treatment to improve the quality of hybridization signals on high density oligonucleotide... Agent: Affymetrix, Inc.

20120164695 - Combinatorial variants of glucoamylase with improved specific activity and/or thermostability: Presently provided are variant glucoamylases displaying altered properties, such as improved thermostability and/or specific activity. Also disclosed are DNA sequences coding for the variants, vectors and host cells incorporating the DNA sequence, enzyme compositions, and methods of using the variants in various applications.... Agent: Danisco US Inc.

20120164694 - Method of producing saccharides containing glucose as major constituent: e

20120164696 - Recombinant beta-glucosidase variants for production of soluble sugars from cellulosic biomass: The invention relates to recombinant expression of a variant form of a fungal C1 strain β-glucosidase. The invention also relates to the generation of fermentable sugars from biomass and the production of biofuels by fermentation of the sugars using genetically modified organisms expressing the β-glucosidase variant. The invention provides methods... Agent: Codexis, Inc.

20120164697 - Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their percursors: Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways,... Agent: Cargill, Incorporated

20120164698 - Method for fermentatively preparing l-amino acids: The invention relates to a method for preparing organic-chemical compounds, characterized in that the following steps are carried out: a) fermentation of a microorganism secreting an L-amino acid, which microorganism contains an overexpressed polynucleotide coding for a polypeptide having polyphosphate-dependent NAD+ kinase activity, in a fermentation medium, to form a... Agent: Evonik Degussa Gmbh

20120164699 - Economical, food-safe extraction of bisphenols: Methods for extracting bisphenols from polymer substrates are described. The methods include contacting the polymer substrate with an aqueous composition which includes a phase transfer agent, a base and optionally an oxidant, whereby the bisphenol is extracted into the aqueous composition. Suitable phase transfer agents are delineated. Also described are... Agent: Empire Technology Development LLC

20120164700 - Prokaryotic acyl-acp thioesterases for producing fatty acids in genetically engineered microorganisms: The described invention provides genetically engineered photosynthetic microorganisms expressing prokaryotic acyl-ACP thioesterases and methods of using the genetically engineered photosynthetic microorganisms for producing free fatty acids and/or fatty acid derivatives.... Agent: Exxonmobil Research And Engineering Company

20120164701 - Renewable chemicals and fuels from oleaginous yeast: The invention provides methods of cultivating oil-bearing microbes using xylose alone or in combination with other depolymerized cellulosic material. Also provided are microorganisms comprising an exogenous gene encoding a polysaccharide degrading enzyme, such as a cellulase, a hemicellulase, a pectinase, or a driselase. Some methods of microbial fermentation are provided... Agent: Solazyme, Inc.

20120164702 - Biological synthesis of difunctional alkanes from carbohydrate feedstocks: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production... Agent: Celexion, LLC

20120164703 - Recombinant microorganisms for increased production of organic acids: Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant... Agent: Michigan Biotechnology Institute

20120164704 - Sugar transport sequences, yeast strains having improved sugar uptake, and methods of use: Disclosed are nucleic acid constructs comprising coding sequences operably linked to a promoter not natively associated with the coding sequence. The coding sequences encode Pichia stipitis proteins that allow recombinant strains of Saccharomyces cerevisiae expressing the protein to grow on xylose, and allow or increase uptake of xylose by Pichia... Agent: Wisconsin Alumni Research Foundation

20120164705 - Metabolic switch: The present invention provides compositions and methods for controlling biosynthetic pathways using a metabolic switch in microorganisms. Photoautotrophs are developed to be auxotrophic for certain exogenous compounds such as lipoic acid and/or a fixed nitrogen source. Depletion of the exogenous compound results in the carbon flux to be diverted to... Agent: Joule Unlimited Technologies, Inc.

20120164706 - System and method for purifying an aqueous organic matter, waste and/or wastewater under pressure and method for producing biogas: The present invention concerns a system and working method for purification and/or treatment of organic waste and/or wastewater flows. The invention also concerns a working method for the production of biogas. The system according to the invention contains: a sealable pressure vessel provided with an inlet to supply a flow... Agent:

20120164707 - Method for producing intracellular microorganisms using a protozoan as a host: The present invention relates to a method for producing intracellular microorganisms such as bacteria, parasitic protozoans or viruses, for example, characterised in that said method essentially comprises using a culture of at least one protozoan as a host cell in which said parasitic or non-parasitic intracellular microorganisms proliferate, and then... Agent:

20120164708 - Stabilized enzyme compositions: The present invention relates to a composition comprising an enzyme and octanol. Additionally, the present invention relates to a composition comprising a transition metal ion.... Agent:

20120164709 - Recombinant beta-glucosidase variants for production of soluble sugars from cellulosic biomass: The invention relates to recombinant expression of a variant form of a fungal C1 strain β-glucosidase. The invention also relates to the generation of fermentable sugars from biomass and the production of biofuels by fermentation of the sugars using genetically modified organisms expressing the β-glucosidase variant. The invention provides methods... Agent: Codexis, Inc.

20120164710 - Method of preparation of a biological particulate structure: The invention provides methods for the preparation of an isolated virus particle or virus-like particle by treating with an agent such that the particles are preferentially in the aqueous phase. The invention also provides methods of preparing a capsomere that is substantially-free of at least one host cell derived chaperone... Agent:

20120164711 - Compositions and methods for improved isoprene production using two types of ispg enzymes: The invention provides for compositions and methods for producing isoprene by using recombinantly engineered cells that utilize a system of dual IspG enzymes in addition to isoprene synthase.... Agent: Danisco US Inc.

20120164712 - Production of algae: A closed system for producing algae moves water that contains algae through an endless reactor tube that defines a continuous pathway. At least part of the tube floats on a volume of water. The tube is transparent to light. Water partially fills the tube and there is a gas space... Agent:

20120164713 - Genetically engineered microorganisms comprising 4-hydroxybenzoyl-coa thioesterases and methods of using the same for producing free fatty acids and fatty acid derivatives: The described invention provides genetically engineered microorganisms, including photosynthetic microorganisms, expressing 4-hydroxybenzoyl-CoA thioesterases and methods of using the genetically engineered microorganisms for producing free fatty acids and/or fatty acid derivatives.... Agent: Exxonmobil Research And Engineering Company

20120164714 - Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of dna: The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials... Agent: University Of South Florida

20120164715 - Device for porcessing a cytological or histological preparation: A device for processing a cytological or histological preparation includes: a carousel, including at least one space for receiving a slide for receiving a cytological or histological preparation, the carousel being rotatably mounted about an axis of rotation; a nebulizing head that passes above the carousel, including the piezoelectric element... Agent: Assistance Publique-h&#xf4 Pitaux De Paris

20120164716 - Biochip sensor: Small and extremely small molecules and ions or atoms may be detected with the novel device with exceptional sensitivity. The detection is implemented in a simple manner by the known acoustic resonator FBAR or by means of other technologies that measure the physical properties of the filled layer. The permeability... Agent: Eth Zurich

20120164717 - Identity profiling of cell surface markers: An apparatus and method of characterizing cells having surface markers includes the use of functionalized probes, the probes having absorption spectra characteristic of a probe geometry. The probes are functionalized with biomolecules (biomarkers) capable of binding to the surface markers, and cells having a particular combination of probes having specific... Agent:

20120164719 - Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching: A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb... Agent: Abbott Point Of Care, Inc.

20120164718 - Removable/disposable apparatus for mems particle sorting device: A micromechanical particle sorting system uses a removable/disposable apparatus which may include a compressible device, a filter apparatus and a cell sorter chip assembly. The chip assembly may include a tubing strain relief manifold and a microfabricated cell sorting chip. The chip assembly may be detachable from the filter apparatus... Agent: Innovative Micro Technology

20120164720 - Biogas plant and service device for a biogas plant: A biogas plant and a servicing device for a biogas plant having a servicing unit and a servicing section, the biogas plant includes a fermenter tank with a fermentation section and a gas section at an interior space of the fermenter tank. The fermenter tank is closed gas-tight by a... Agent:

20120164721 - Cell culture apparatus: A cell culture apparatus has four sections, including a cell culture chamber, refrigerator, control unit, and intermediate chamber. The cell culture chamber includes a culture vessel base as a holding member for holding and installing a culture vessel, a microscope for photographing a cell image within the culture vessel, and... Agent: Hitachi, Ltd.

20120164722 - Lighting apparatus for a bioreactor to enhance biological material growth: A lighting apparatus (10) for a bioreactor including a plurality of coloured light emitting diodes (11) mounted on a support (21), the number and colour of the light emitting diodes chosen to provide predetermined spectral wavelengths and an optical device (13) to transmit the emitted light to a biological material... Agent:

20120164723 - Reaction system for anaerobic digestion: The present invention provides an anaerobic digestion reaction system. This system includes a continuously stirred reaction tank having an agitator contained therein and one or more outlet pipes. A blend tank for receiving organic waste feedstock is in communication with the continuously stirred reaction tank. Organic waste feedstock is transferred... Agent:

20120164725 - Deepwell plate system with lid: The present invention relates to a deepwell plate system, comprising a deepwell plate and a lid system which can be detachably fitted to the deepwell plate by snap- or clamp-fastening means so as to tightly seal the deepwell plate and to a method for the cultivation of cells within the... Agent:

20120164724 - Novel aminotransferase, gene encoding the same, and methods of using them: The invention relates to a novel aminotransferase, DNA encoding the enzyme, a recombinant vector into which the DNA has been introduced, and a transformant into which the vector has been introduced. Further, the invention also relates to a method for producing an optically active amino compound utilizing the enzyme or... Agent:

20120164726 - Bivalent, bispecific antibodies: The present invention relates to a host cell for use in the expression of a novel domain exchanged, bivalent, bispecific antibody.... Agent:

20120164727 - Productivity augmenting protein factor, novel cell lines and uses thereof: The present invention provides a method for preparing a non-adenoviral target virus or target proteins utilizing a potent expression cell line having stably integrated into its genome a gene encoding a specific heterologous regulator protein.... Agent: Probiogen Ag

20120164728 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.

20120164729 - Composition for culturing pluripotent stem cells and use thereof: Disclosed are a composition for pluripotent stem cell culture containing activin (preferably, activin A); a medium for pluripotent stem cell culture containing the composition; a method for culturing pluripotent stem cells for proliferating or establishing pluripotent stem cells such as iPS cells (preferably, mammalian iPS cells, and particularly preferably, human... Agent: National University Corporation Chiba University

20120164730 - Compositions for silencing the expression of vdac1 and uses thereof: The present invention relates generally to the down regulation of mitochondrial protein, voltage-dependent anion channel (VDAC1) expression by RNAi or antisense therapy. In particular, the present invention is directed to VDAC1 silencing molecules useful in regulating cell proliferation and to pharmaceutical compositions comprising same useful in the treatment of diseases... Agent: Ben-gurion University Of The Negev Research And Development Authority Ltd.

20120164731 - Method of inducing differentiation from pluripotent stem cells to skeletal muscle progenitor cells: Provided is a method of producing a skeletal muscle progenitor cell using a pluripotent stem cell, particularly an iPS cell, the method comprising the step 1) of culturing a pluripotent stem cell under serum-free conditions, and in the presence of Activin A, to allow the cell to differentiate into a... Agent: Kyoto University

20120164732 - Cancer tissue-derived cell mass and a process for preparing same: Disclosed is a novel cell mass derived from a cancer tissue, which can reflect the in vivo behavior of a cancer cell correctly. Also disclosed is a process for preparing the cell mass. Specifically disclosed is a cell mass derived from a cancer tissue, which is an separated product that... Agent: Rei Medical Co., Ltd.

20120164733 - In-vitro fertilization systems with spermatozoa separated into x-chromosome and y-chromosome bearing populations: An IVF system for successfully utilizing spermatozoa separated into X-chromosome bearing and into Y-chromosome bearing population for insemination. The IVF system includes fertilization medium that can shorten the time from insemination to cleavage and a portable incubator for the transportation of maturing oocytes and inseminated oocytes comprising a straw (19)... Agent: Xy, LLC

20120164734 - Nucleotides encoding stop codons in multiple reading frames and methods of use: Compositions having polynucleotides encoding multiple translational stop signals in more than one reading frame are provided. The compositions include isolated polynucleotides, expression cassettes, and vectors, as well as host cells, prokaryotic organisms, and eukaryotic organisms comprising the polynucleotide(s). Methods include using the polynucleotides to stop translation of an mRNA into... Agent: Pioneer Hi Bred International Inc

  
06/21/2012 > 118 patent applications in 69 patent subcategories. invention type

20120156669 - Biomass production: A process of growing a phototrophic biomass in a reaction zone, including a reaction mixture that is operative for effecting photosynthesis upon exposure to photosynthetically active light radiation, is provided. The reaction mixture includes phototrophic biomass that is operative for growth within the reaction zone. In one aspect, the carbon... Agent: Pond Biofuels Inc.

20120156670 - In vitro urogenital co-culture models: The invention is directed to co-culture systems comprising (i) rotating wall vessel (RWV)-cultured epithelial or differentiated tissue attached to microcarrier beads and (ii) the peripheral tissue equivalent (PTE) module of the MIMIC® system, and to methods of using the co-culture systems for assessing chemical or biological (bacterial or viral) insults.... Agent: Sanofi Pasteur Vaxdesign Corp.

20120156671 - Labelled nucleotides: The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: Formula (1) (wherein X is selected from the group comprising O, S, NH and NQ wherein Q... Agent: Illumina Cambridge Limited

20120156673 - Methods for agrobacterium-mediated transformation of sugar cane: The present invention provides methods for producing a transformed sugar cane tissue or cell thereof, said methods comprising: a) inoculating a sugar cane tissue or a cell thereof with an Agrobacterium inoculation suspension, said Agrobacterium comprising a nucleic acid of interest, to obtain an Agrobacterium-inoculated sugar cane tissue or cell... Agent:

20120156672 - Novel stringent selectable markers: The present invention relates to nucleic acid constructs comprising selectable marker genes in a multicistronic transcription unit for use in the generation and selection of eukaryotic host cells for expression of a gene product of interest. For increased stringency of selection, the coding sequence of the selectable marker may be... Agent: Cella Genics B.v.

20120156678 - Binding-induced hairpin detection system: This application relates to a binding-induced hairpin detection system comprising: a. a first probe comprising a targeting molecule and an oligonucleotide that has a free end and an end attached to the targeting molecule; and b. a second probe comprising a targeting molecule and an oligonucleotide that has an end... Agent: The Governors Of The University Of Alberta

20120156677 - Detection and quantification of hydroxymethylated nucleotides in a polynucleotide preparation: Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use... Agent: New England Biolabs, Inc.

20120156674 - Methods of differentiating between non-genotoxin and genotoxin-associated tumors: Embodiments of the present disclosure are directed to methods of differentiation of non-genotoxin associated versus genotoxin-associated tumors.... Agent:

20120156675 - Picowell capture devices for analysing single cells or other particles: A convenient way of isolating individual cells permits individual analysis of their contents. A capture support for individually capturing cells of interest comprises a first surface including at least one well sized to accommodate an individual cell, wherein the support is made of a differentially permeable material which permits transfer... Agent: Oxford Gene TechnologyIPLimited

20120156676 - Single nucleotide polymorphisms in brca1 and cancer risk: The invention provides methods for identifying mutations, such as single nucleotide polymorphisms (SNPs), within breast and ovarian cancer associated genes that modify the binding efficacy of microRNAs (miRNAs). In a preferred embodiment, methods of the invention identify a SNP that decreases expression of the BRCA1 gene by increasing or decreasing... Agent:

20120156682 - Allelic discrimination analysis using an efficiency related value (efr): In various embodiments this invention provides novel methods for discriminating two or more different target nucleic acids. In certain embodiments the methods comprise providing data amplification reactions comprising reagents to amplify two or more different target nucleic acids where the data comprise signals comprising an amplitude measurement representing the degree... Agent: Abbott Laboratories

20120156681 - Composition for diagnosis of liver metastasis of colorectal cancer and the use thereof: The present invention relates to a composition for diagnosis of liver metastasis of colorectal cancer and the use thereof, and more particularly to a composition for diagnosis of liver metastasis of colorectal cancer, which comprises either a substance for measuring the mRNA level of CCL7 (Chemokine (C-C motif) ligand 7)... Agent:

20120156685 - Method for detecting and quantifying rare mutations/polymorphisms: The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare mutation can be any type of functional or non-functional nucleic acid change or mutation, such as deletion,... Agent: Trustees Of Boston University

20120156679 - Methods for making transcription products: The present invention provides methods, compositions and kits for using an RNA polymerase for making transcription products corresponding to a target sequence by obtaining circular single-stranded DNA transcription substrates using a promoter primer that encodes one strand of a double-stranded promoter. The invention has broad applicability for research, diagnostic and... Agent: Epicentre Technologies

20120156683 - One-step method of elution of dna from blood samples: Described are reagents, methods, and kits for eluting, and amplifying and/or characterizing DNA from liquid and dried blood samples. A one-step DNA elution buffer has been developed that simplifies purification of DNA from blood samples. The purified DNA is suitable for use in subsequent widely used techniques such as enzymatic... Agent:

20120156684 - Selection method of induced pluripotent stem cells: The present invention relates to a method for selecting induced pluripotent stem (iPS) cells. More particularly, the present invention provides: a method for selecting an iPS cell, comprising the steps of: (1a) measuring the expression level of an exogenous nuclear reprogramming gene(s) in a test iPS cell; and (2a) selecting... Agent: Kyoto University

20120156680 - Synthesis of four-color 3'-o-allyl modified photocleavable fluorescent nucleotides and related methods: This invention provides a process for making 3′-O-allyl-dGTP-PC-Biodopy-FL-510, 3′-O-allyl-dATP-PC-ROX, 3′-O-allyl-dCTP-PC-Bodipy-650 and 3′-O-allyl-dUTP-PC-R6G, and related methods.... Agent: The Trustees Of Columbia University In The City Of New York

20120156686 - Multifunctional particles providing cellular uptake and magnetic motor effect: Preparation of novel multifunctional particles and nanomaterials having a useful combination of magnetic and optical properties and biocompatibility. The internalization efficiencies in various in vitro cell studies have been investigated, and the external magnetic motor effect on the floating cells internalized with magnetic nanoparticles were clearly observed, for the first... Agent:

20120156687 - Nanoparticles with molecular recognition elements: A method of multiple protein biomarker detection, comprising providing at quantum dot-antibody conjugates that have an affinity for at least two different protein biomarkers; contacting the conjugates with a sample from a subject; allowing the proteins to bridge the antibodies, forming protein biomarker/quantum dot-antibody conjugate agglomerates; detecting the presence of... Agent:

20120156688 - Use and making of biosensors utilizing antimicrobial peptides for highly sensitive biological monitoring: A biosensor and method of making are disclosed. The biosensor is configured to detect a target and may include a peptide immobilized on a sensing component, the sensing component having an anode and a cathode. The immobilized peptide may comprise an antimicrobial peptide binding motif for the target. The sensing... Agent:

20120156689 - Method and apparatus for determining an analyte parameter: A method of determining an analyte parameter is described for an analyte in a detection region having at least one analyte binding zone. The method includes detecting presence of an analyte element bound at the binding zone, incrementing or decrementing a count and preventing recount of the element to obtain... Agent: Imperial Innovations Limited

20120156696 - container for forming a cell aggregate and a method for forming a cell aggregate: (in the formula, each of R1, R2, and R3 is independently a an alkyl group with a carbon number of 1 or more and 6 or less and m is an integer of 2 or more and 6 or less.) and at least one of an amino group, a carboxyl... Agent: Shiseido Company, Ltd.

20120156697 - Method for identifying an agent that inhibits candida albicans-mediated host cell differentiation: The present invention features a method for identifying an agent that inhibits Candida albicans-mediated differentiation of keratinocytes. Agents identified by the screening assay of the invention find application in the prevention and treatment of candidiasis.... Agent: Trustees Of Dartmouth College

20120156695 - Microorganism for expressing a human membrane protein: The invention relates to an isolated, genetically modified, living non-mammal organism, having increased HMG-CoA-reductase activity compared to the wild type, and having reduced C24-methyltransferase and/or delta22-desaturase activity compared to the wild type. The invention is characterized in that the organism has increased dehydrocholesterol-delta70-reductase activity compared to the wild type. The... Agent: Organobalance Gmbh

20120156698 - Device and methods for the detection of cervical disease: The present invention discloses a novel device and methods thereof with utility application in the high-throughput detection, screening and disease management of cervical disease. The “multiwell” device of the present invention consists of a solid support featuring multiple well-separated areas, each accommodating a patient sample, leading to simultaneous evaluation of... Agent: Milagen, Inc.

20120156699 - Pathogenic th17 cells; related reagents and methods: Methods and compositions are provided for the treatment of immune disorders, such as autoimmune diseases, or cancers, involving combination therapy with agents that inhibit the development or maintenance of Th17 cells. Treatment regimens are provided in which an antagonist of a pro-inflammatory cytokine is administered for a time sufficient to... Agent: Schering Corporation

20120156691 - Compound: Alternative methods for the detection and measurement of proteases in biological samples and compounds which allow for such detection are required to allow for rapid and selective identification of these enzymes. Compounds which allow for selective identification of these enzymes are provided with assays and kits for their use.... Agent: Queen's University Of Belfast

20120156690 - Method for diagnosing hemangiosarcoma in canine using detection of thymidine kinase activity: The disclosure relates to a method for detecting hemangiosarcoma in canines. The method includes the steps of: (1) obtaining a quantity of blood from the subject canine; (2) separating the quantity of blood into a serum portion and a non-serum portion; (3) contacting the serum portion of the blood with... Agent:

20120156692 - Method for selecting marker for diagnosis of nutritional status of plant, method for diagnosing nutritional status of plant, and method for determining growth status: The present invention provides a method for selecting a marker for diagnosis of the nutritional status capable of reflecting the status of a particular nutrient in a plant without being influenced by various stresses in environmental factors, etc., and a method for diagnosing the status of a particular nutrient in... Agent: Oji Paper Co., Ltd.

20120156693 - Methods of signal generation and signal localization for improvement of signal readability in solid phase based bioassays: A method for generating and localizing a signal in a solid phase substrate detection system comprises applying a solution of target material to a substrate; binding the target with a specific affinity molecule having an attached label, the label comprising multiple signal precursor molecules; applying a carrier to the substrate,... Agent: Supernova Diagnostics, Inc.

20120156694 - Proteins used for the diagnosis of lyme borreliosis: Chimera proteins including: (i) at least one sequence of a VlsE protein of a Borrelia species selected from B. garinii, B. burgdorferi sensu stricto and B. afzelii, and (ii) at least one sequence including sequences of the IR6 domain of B. burgdorferi sensu stricto, B. afzelii and B. garinii. Also,... Agent: Biomerieux

20120156702 - Cmybp-c and mlc2 as diagnostic markers of cardiac injury: The invention relates to markers for acute myocardial infarction (AMI), particularly markers that may be used in the rapid and accurate diagnosis of AMI or reinfarction. A method of diagnosing cardiac injury comprising identifying an elevated concentration of cardiac myosin binding protein C (cMyBP-C) or a fragment thereof or myosin... Agent: King's College London

20120156700 - Detection and quantitation of urine gelsolin: The invention relates generally to gelsolin binding agents (e.g., antibodies) which can bind to gelsolin polypeptides. Gelsolin binding agents of the invention are useful, alone or in combination, to detect a gelsolin polypeptide in a test sample. In particular, the gelsolin binding agents are useful in assays of urine samples... Agent:

20120156704 - In vitro method for detecting gp91phox as a marker of oxidative stress: The invention relates to an in vitro method for detecting the activation of NADPH oxidase by measuring gp91phox protein levels in biological fluids, as a marker of oxidative stress. The method is useful for testing the oxidative stress levels in dysmetabolic pathologies, such as diabetes, hypercholesterolemia and hyperlipidemia, in pathologies... Agent: Bios International S.r.l.

20120156701 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect C-X-C motif chemokines-1, -2, and -3 as diagnostic and prognostic biomarker assays... Agent:

20120156703 - Use of mimecan in the assessment of heart failure: The disclosure relates to assessing heart failure in vitro by measuring the concentration of the marker mimecan in a sample, and optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration of mimecan and the... Agent: Roche Diagnostics Operations, Inc.

20120156705 - luciferases and uses thereof: The present invention encompasses modified luciferases, methods for making modified luciferases, and assays utilizing modified luciferases. Modified luciferases of the invention show increased activity over wildtype luciferases and also show increased stability of signal. The present invention also encompasses multiplex assays utilizing multiple luciferases with different emission spectra.... Agent: Targeting Systems

20120156706 - process for the identification and preparation of a (r)-specific omega-transaminase: The present invention relates to processes for the screening, preparation and characterization of (R)-selective ω-transaminases, to transaminases obtained thereby and their uses in various transamination processes.... Agent: Lonza Ag

20120156709 - Electrochemical assay for the detection of enzymes: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process.... Agent: Ohmx Corporation

20120156710 - Method for quantifying protein: (D) identifying, in the MRM chromatogram detected in step (C), a peptide derived from the target protein (a target peptide) that shows the same retention time as a peptide derived from the internal standard (an internal standard peptide), and quantifying the target protein in the test sample by comparing the... Agent: Kyushu University, National University Corporation

20120156708 - Method for simultaneously determining multiple coagulation proteases: The present invention relates to a chromogenic method for simultaneously determining the activity of multiple coagulation proteases or for simultaneously determining the inhibition of multiple coagulation proteases in a single test reaction. For this purpose, use is made of two chromogenic substrates which have different absorption maxima and whose color... Agent: Siemens Healthcare Diagnostics Products Gmbh

20120156707 - Proteome analysis in mass spectrometers containing rf ion traps: A complex protein mixture is analyzed by jointly digesting the mixture, separating the digest peptides chromatographically or electrophoretically, and ionizing the digest peptides eluting from the separation device by an ionizing method that generates multiply charged ions. Digest peptide ions within a pre-selected range of m/z-values are isolated in an... Agent: Bruker Daltonik Gmbh

20120156714 - Integrated cytometric sensor system and method: The invention provides a flow cytometric system comprising a first sensor positioned axially to a light source; a channel comprising means for receiving a sample target and interposed between said first sensor and light source; and a second sensor placed at an angle to said first sensor adapted to sense... Agent: Radisens Diagnostics Limited

20120156713 - Method for analyzing and/or treating a fertilized egg, and corresponding system: The present invention relates to a method for analyzing and/or treating a fertilized egg and a system able to implement said method. According to the invention, the method comprises a step of puncturing and/or injecting substance into the albumin sac of the egg, said egg having between 5 and 19... Agent:

20120156712 - System and method for identification of biological tissues: The present invention provides for a system, method, and device for analyzing, localizing and/or identifying tissue types. The method includes analyzing, localizing and/or identifying one or more tissue samples, characterized in that the method comprises: (a) generating gaseous tissue particles from a site in the one or more tissue samples,... Agent: Medimass Kft.

20120156711 - System and method that allows the joined performance of optoelectric and respirometric sensors for instant and accurate ascertainment of biochemical oxygen demand (bod) in liquid industrial wastes: The present invention provides a system and method that combines the rapidity of the optoelectric signal and the simplicity of the respirometric cartridge wherein the greater accuracy of the respirometric biosensor is added to the rapidity of the optoelectric sensor, with the purpose of improving the accuracy of the measurements... Agent: Universidad Tecnica Federico Santa Maria

20120156715 - Environmental sentinel biomonitor system (esb): An embodiment of the invention provides a system for toxicity identification in water. The system includes a cell maintenance device having a cooling component that maintains an internal storage area of the cell maintenance device within a temperature range of 4 degrees Celsius to 25 degrees Celsius. Fluidic biochips in... Agent:

20120156716 - Methods for the isolation, accumulation, characterization and/or identification of microorganisms using a filtration and sample transfer device: The present invention is directed to methods, devises and kits for separating, accumulating, characterizing and/or identifying microorganisms known to be present or that may be present in a test sample. The method of the invention comprises optional lysing non-microorganism cells and/or particulates that may be present in a test sample,... Agent: Biomerieux, Inc.

20120156717 - Biofuel from recombinant oleaginous algae using sugar carbon sources: Recombinant oleaginous alga that include one or more heterologous genes that increase the ability of the alga to use one or more natural saccharides such as cellulosic or hemicellulosic sugars for algal growth are described. The recombinant oleaginous algae are transformed to include one or more genes expressing sugar metabolizing... Agent: Phycal, Inc.

20120156718 - Production of ketocarotenoids in plants: The present invention relates to optimized ketolase coding sequences, corresponding coding sequences and genetic constructs alone or in combination with beta-cyclase coding sequences, their use for the expression in plants, in particular in plants of the genus Tagetes, to such genetically modified plants, to a process for the preparation of... Agent: Basf Plant Science Gmbh

20120156721 - Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity: This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine hydrolases have one or more amino acid residues in a subsite replaced with a cysteine, wherein the cysteine is modified by replacing the thiol hydrogen in the... Agent: The Governing Council Of The University Of Toronto

20120156720 - Compositions and methods of producing enterokinase in yeast: The present specification disclose polynucleotide molecules encoding an enterokinase, yeast expression constructs including a yeast expression vector and a polynucleotide molecules encoding an enterokinase, yeast cells comprising such a yeast expression construct, methods of producing enterokinase using such yeast cells, and method of cleaving or preparing a recombinant polypeptide using... Agent: Allergan, Inc.

20120156719 - Method for universal enzymatic production of bioactive peptides: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.... Agent:

20120156722 - Tumor suppressor gene: A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells... Agent: Chugai Seiyaku Kabushiki Kaisha

20120156723 - Protein glycosylation: The disclosure relates to an oligosaccharyltransferase polypeptide and the production of glycosylated recombinant protein in a microbial host cell; and including vaccines comprising glycosylated recombinant antigens.... Agent:

20120156725 - Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors: Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.... Agent: Amgen Inc.

20120156724 - Humanized anti-cd47 antibody: The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing... Agent: Chugai Seiyaku Kabushiki Kaisha

20120156726 - Velocity factor: The current invention is directed to the velocity factor. Based on the velocity factor antibodies can be classified, i.e. antibodies can be characterized on their binding properties as e.g. entropic or enthalpic antigen binder. A velocity factor based classification does not require detailed thermodynamic determinations and/or calculations. The velocity factor... Agent:

20120156727 - Pretreatment of non-wood lignocellulosic material: The present disclosure provides a method for pre-treating non-wood lignocellulosic material containing less than 5 % (w/w) starch or sugar in a process for production of ethanol from lignocellulose, comprising the steps of: adding organic acid or organic acid-producing bacteria to the lignocellulosic material; storing the lignocellulosic material in the... Agent:

20120156728 - Clonal amplification of nucleic acid on solid surface with template walking: Novel methods of generating a localized population of immobilized clonal amplicons on a support are provided.... Agent: Life Technologies Corporation

20120156729 - Selective terminal tagging of nucleic acids: Methods are provided for adding a terminal sequence tag to nucleic acid molecules for use in RNA or DNA amplification. The tag introduced may be used as a primer binding site for subsequent amplification of the DNA molecule and/or sequencing of the DNA molecule and therefore provides means for identification... Agent:

20120156730 - Ligation method employing eukaryotic trna ligase: Provided herein is a method of preparing an RNA sample comprising: a) obtaining an RNA sample comprising: i. long RNA molecules that may be unfragmented or fragmented to contain 5′-OH group and a 2′-3′-cyclic phosphate group; and ii. short RNA molecules that comprise a 5′ phosphate group and a 3′... Agent:

20120156731 - Improved methods for rapid gene synthesis: Disclosed are methods and materials for assembling long polynucleotides from synthetic oligonucleotides. The use of synthetic oligonucleotides permits non-natural design of sequences. The oligonucleotides used for construction may be relatively short, according to practicalities of nucleotide synthesis. They are assembled using a ligase which is operative over a range of... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20120156732 - Useful polypeptides: The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using the... Agent: Kyowa Hakko Kirin Co., Ltd.

20120156733 - Geobacillus stearothermophilus alpha amylase (amys) variants with improved properties: Described are variants of a parent α-amylase that exhibits an alteration in at least one of the following properties relative to said parent α-amylase: specific activity, substrate specificity, substrate binding, substrate cleavage, thermal stability, pH-dependent activity, pH-dependent stability, oxidative stability, Ca2+ dependency, pI, and wash performance. The variants are suitable... Agent: Danisco US Inc.

20120156734 - Thermostable paenibacillus xylanases: This invention relates to mutant xylanases, nucleic acids encoding them, and methods of using these xylanases.... Agent: Academica Sinica

20120156736 - Method for producing l-lysine using a vibrio bacterium: L-Lysine is produced by culturing in a medium a Vibrio bacterium which has an ability to produce L-lysine, and has been modified so that an activity of a protein encoded by the fucO gene is reduced to produce and accumulate L-lysine in the medium or cells of the bacterium, and... Agent:

20120156735 - Recombinant host cells comprising phosphoketolases: The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related... Agent: Butamax(tm) Advanced Biofuels LLC

20120156737 - Preparation of alpha-ketopimelic acid: The invention relates to a method for preparing alpha-ketopimelic acid, comprising converting alpha-ketoglutaric acid into alpha-ketoadipic acid and converting alpha-ketoadipic acid into alpha-ketopimelic acid, wherein at least one of these conversions is carried out using a heterologous biocatalyst. The invention further relates to a heterologous cell, comprising one or more... Agent: DsmIPAssets B.v.

20120156738 - Production of alcohol esters and in situ product removal during alcohol fermentation: An alcohol fermentation process and composition that includes production of alcohol esters by esterification of product alcohol in a fermentation medium with a carboxylic acid (e.g., fatty acid) and a catalyst (e.g., lipase) capable of esterifying the product alcohol, such as butanol, with the carboxylic acid to form the alcohol... Agent: Butamax(tm) Advanced Biofuels LLC

20120156739 - Fermentation method: This invention relates to the integration of an ammonia production process with a fermentation process to produce products such as alcohols and/or acids in addition to ammonia. In a specific embodiment, a natural gas stream comprising methane is passed to a reforming zone to produce a substrate comprising CO and... Agent: Lanzatech New Zealand Limited

20120156740 - Microorganisms and methods for the production of 1,4-cyclohexanedimethanol: A non-naturally occurring microbial organism includes a microbial organism having a 1,4-cyclohexanedimethanol pathway that includes at least one exogenous nucleic acid encoding a 1,4-cyclohexanedimethanol pathway enzyme expressed in a sufficient amount to produce 1,4-cyclohexanedimethanol. A method for producing 1,4-cyclohexanedimethanol includes culturing a non-naturally occurring microbial organism having a 1,4-cyclohexanedimethanol pathway.... Agent: Genomatica, Inc.

20120156744 - Multi-phase, gas-lift bioreactor for generation of biogas or biofuel from organic material: Provided herein is a multi-phase, gas-lift bioreactor device for digestion and production of biogas or biofuel from organic material, as well as methods of use thereof.... Agent:

20120156741 - Process for the production of alcohols from biomass: Alcohols useful as fuel compositions are produced from biomass by pretreating the biomass prior to hydrolysis and fermentation. In the pretreatment, the biomass is contacted with an aqueous solution containing a dilute acid with concentration of up to 10 wt % producing a predigested stream containing an aqueous liquor that... Agent: Shell Oil Company

20120156742 - Process to produce biofuels from biomass: A method to produce biofuels from biomass is provide by contacting the biomass with an aqueous media to form an extracted biomass, separating at least a portion of an aqueous liquor from the extracted biomass thereby providing the aqueous liquor stream comprising soluble carbohydrates; contacting the aqueous liquor stream with... Agent: Shell Oil Company

20120156743 - Process to produce biofuels from biomass: A method to produce biofuels from biomass is provide by contacting the biomass with an aqueous media to form an extracted biomass, separating at least a portion of an aqueous liquor from the extracted biomass thereby providing the aqueous liquor stream comprising soluble carbohydrates; contacting the aqueous liquor stream with... Agent: Shell Oil Company

20120156745 - Methyl butenol synthase: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.... Agent:

20120156746 - xylose utilization in recombinant zymomonas: Xylose-utilizing Zymomonas strains studied were found to accumulate ribulose when grown in xylose-containing media. Engineering these strains to increase ribose-5-phosphate isomerase activity led to reduced ribulose accumulation, improved growth, improved xylose utilization, and increased ethanol production.... Agent:

20120156747 - Novel ethanologenic clostridium species, clostridium coskatii: An isolated clostridia bacterial species (Clostridium coskatii ATCC No. PTA-10522, “PS02”) is provided. Under anaerobic conditions C. coskatii can convert CO and/or H2 and/or CO2 to ethanol or acetate. Thus, this bacterium is capable of transforming waste gases (e.g. syngas and refinery wastes) into useful products.... Agent: Coskata, Inc.

20120156748 - Process for treatment of a lignocellulosic material: A process for treatment of a lignocellulosic material comprising contacting the lignocellulosic material with a solution of chloride ions, which solution comprises a concentration of chloride ions in the range from equal to or more than 1 ppm weight to equal to or less than 350 ppm weight based on... Agent: Shell Oil Company

20120156749 - Separating material and method for collecting cell or the like using the same: The present invention provides a novel material useful for selectively isolating a cell such as monocyte and the like or a protein from a body fluid and a production method thereof, a physiological material using the material and an isolation material using the physiological material, as well as a method... Agent: Kaneka Corporation

20120156750 - Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices: Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular biological testing. Sensitive reagents are stored in dry form without lyophilization or freezing, and reconstituted at the point of use with either a biological sample or a sample eluate at the point... Agent: Micronics, Inc.

20120156751 - Preparation and isolation of 5' capped mrna: The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool for identifying RNA-protein interactions. Such capped RNA finds use... Agent: Applied Biosystems, LLC

20120156752 - Production of nucleic acid: separating the complexes into compartments wherein most or all of the compartments contain no more than one complex; (d) subjecting the complexes to reaction conditions which allow target protein activity; and (e) selecting nucleic acid encoding the target protein on the basis of the activity associated therewith, wherein when the... Agent: Fermentas Uab

20120156753 - Selective 5' ligation tagging of rna: The present invention provides novel compositions, kits and methods employing RNA 5′ polyphosphatases, RNA 5′ monophosphatases, capping enzymes, decapping enzymes, nucleic acid pyrophosphatases and RNA ligases, as well as other enzymes, for selective 5′ ligation tagging of desired classes of RNA molecules that differ with respect to particular chemical moieties... Agent: Illumina, Inc.

20120156755 - Polypeptides having cellobiohydrolase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20120156754 - Variant cbh2 cellulases and related polynucleotides: The invention provides variants of a Streptomyces sp. CBH2 that have improved properties compared to the wild type enzyme and methods of using the variants in the hydrolysis of substrates comprising cellulose.... Agent: Codexis, Inc.

20120156756 - Process and system for obtaining botulinum neurotoxin: Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.... Agent: Allergan, Inc.

20120156757 - Purification of immunogens using a non-polysaccharide matrix: The present invention relates, at least in part, to novel and improved chromatography matrices for separating or purifying immunogens, such as, for example, viruses and viral surface proteins, from one or more contaminants in a sample, where the matrix comprises a porous non-polysaccharide solid support comprising a negatively charged, multivalent... Agent: Millipore Corporation

20120156758 - Recombinant influenza viruses for vaccines and gene therapy: The invention provides compositions and methods useful to prepare segmented, negative strand RNA viruses, e.g., orthomyxoviruses such as influenza A viruses, entirely from cloned cDNAs and in the absence of helper virus.... Agent:

20120156759 - Method and product for decomposing organic compounds: A method for the biological decomposition of organic compounds of the group of hydrocarbons, fats, oils, waxes, and derivatives thereof as well as mixtures thereof in media polluted therewith, in the presence of at least one dispersant, wherein the medium polluted with the pollutants is treated with at least one... Agent: Georg Fritzmeier Gmbh & Co. Kg

20120156760 - Method for producing lactic acid bacteria having enhanced immunoregulating activities: The present invention provides a method for producing lactic acid bacteria having enhanced immunostimulating activities. Cultivation at a temperature that is higher than the recommended cultivation temperature of the lactic acid bacteria to be used increases the cell wall amount and the cell wall thickness. The immunoregulating activities of the... Agent: Suntory Holdings Limited

20120156761 - Biological methods for preparing adipic acid: The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.... Agent: Verdezyne, Inc.

20120156762 - Solar hybrid photobioreactor: A photobioreactor system is provided that comprises a bioreactor including at least two bioreactor tubes, each having an end and a hollow interior, the ends being connectively joined by one or more connector units having a hollow portion defined by a circumference, a solar concentrator configured to collect and concentrate... Agent: Ge Lighting Solutions, LLC.

20120156763 - Apparatus and methods for using biological material to discriminate an agent: An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of... Agent: Vanderbilt University

20120156764 - Automated analyzer: The automatic analyzer repeatedly performs a first processing operation for creating a pretreated specimen with a pretreatment solution in a first reaction cell. The analyzer also repeatedly performs a second processing operation for creating a reacted specimen by reacting the pretreated specimen with a reagent in a second reaction cell.... Agent: Jeol Ltd.

20120156765 - Fluid filtering device: The invention relates to a fluid filtering device comprising a filter (2) for filtering a fluid and a substrate (3) comprising a collecting structure (4) for collecting the filtered fluid from the filter (2). An adhesive (5) holds the filter (2) in place with respect to the collecting structure (4).... Agent: Koninklijke Philips Electronics N.v.

20120156766 - Sample analyzing chip and measurement system using same: Temperature of a sensor chip itself rises with the supply of power owing to temperature dependence of the sensor chip as its basic characteristics. When a chemiluminescence reagent is added at the point of time at which the temperature rise reaches a steady state and a sensor chip photodiode dark... Agent:

20120156767 - Pcr device: PCR device (1) comprising at least a chamber (2), the chamber (2) being delimited on one side by a PCR substrate (3) at least partially covered by a polyelectrolyte coating (4) forming hydrophilic regions. The polyelectrolyte coating comprises at least one layer facing the chamber (2), the layer being a... Agent: Stmicroelectronics S.r.l.

20120156768 - Pressure and circulation culture apparatus and pressure and circulation culture system: The pressure and circulation culture apparatus includes a holder (culture chamber part), a pressure transmission part and a culture solution circulation line (culture circuit). The holder is a means that reserves culture solution and that holds a cultured object. The pressure transmission part is a means that communicates with the... Agent: Purpose Co., Ltd.

20120156769 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.

20120156770 - Human androgen receptor alternative splice variants: The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate... Agent: University Of Maryland, Baltimore

20120156771 - Functional disruption of an immunoglobulin gene in an avian embryonic stem cell: A transgenic chicken is disclosed having disrupted endogenous immunoglobulin production. In one embodiment, a targeting construct is stably integrated into the genome of the chicken by homologous recombination in embryonic stem cells, and injection of the engineered embryonic stem cells into recipient embryos, thereby knocking out the endogenous immunoglobulin gene... Agent: Origen Therapeutics, Inc.

20120156772 - Cell carrier and methods of making: In one example of a carrier for growing adherent cells, comprises one or more surfaces; and one or more relief features on one or more of the surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in... Agent: General Electric Company

20120156773 - Cell carrier, methods of making and use: A method of culturing adherent cells is provided, wherein the method comprises providing a carrier for growing the cells, comprising one or more surfaces; and one or more relief features/indentations are present on one or more of the surfaces, wherein the carrier has a length at least about 0.2 mm,... Agent: General Electric Company

20120156776 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.

20120156774 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.

20120156775 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.

20120156777 - Cell carrier, associated methods for making cell carrier and culturing cells using the same: A carrier for growing adherent cells is provided, wherein the carrier comprises one or more outer surfaces; and one or more structured indentations on one or more of the outer surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and... Agent: General Electric Company

20120156778 - Method for efficient production of induced pluripotent stem cells utilizing cells derived from oral mucosa: A main object of the present invention is to provide a technique to produce iPS cells with less burden on the patient and with high establishment efficiency. iPS cells can be efficiently produced with significantly improved establishment efficiency by selecting cells derived from oral mucosa and introducing, into the cells,... Agent: Osaka University

20120156779 - Method for cell expansion: The present invention relates to a method for cell expansion. In the method, preferably a cell culture product is used, such as a microcarrier, or other adherent cell culture surface, comprising degradable polysaccharide, preferably starch, modified with small molecular weight cell-binding ligands. This allows recovery (detachment) of adhered cells to... Agent: Ge Healthcare Bio-sciences Ab

20120156780 - Polymer substrates having improved biological response from hkdcs: A method of surface modification of a biocompatible, biodegradable polymer substrate using RF plasma treatment is disclosed. This method and the resulting surface provide for enhanced adhesion and proliferation of cells, such as hKDCs, and can be used with scaffolds for tissue regeneration and with other delivery vehicles such as... Agent:

20120156781 - Temperature-responsive cell culture substrate on which a straight-chain temperature-responsive polymer is immobilized, and manufacturing method therefor: Provided is a temperature-responsive cell culture substrate. A non-crosslinked temperature-responsive polymer having a molecular weight between 10,000 and 150,000 is immobilized on the substrate surface with a density of 0.02 to 0.3 molecular chain per square nanometer. Using the provided temperature-responsive cell culture substrate, cells obtained from various tissues can... Agent:

20120156782 - Cell culture medium: The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells. When pluripotent human embryonic stem cells are cultured... Agent: Biolamina Ab

20120156783 - Automated liquid manufacturing system: A method for continuously preparing a medium formulation mixes a diluent with a plurality of chemically incompatible concentrate solutions in such a manner that none of the ingredients of the concentrate solutions chemically react in an adverse manner. The method utilizes a static mixing chamber to add the concentrate solutions... Agent: Life Technologies Corporation

20120156784 - Methods for improving competency of plant cells: The present invention provides methods for improving competency of plant cells for bacterial-mediated transformation comprising contacting the plant cells with an effective amount of polyethylene glycol (PEG) for a period of time prior to transformation. The ability to store and maintain competent plant cells for transformation and tissue culture allows... Agent:

20120156785 - Methods and products for biasing cellular development: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes... Agent:

20120156786 - Ready-to-use electroporation cuvette including frozen electrocompetent cells: A ready-to-use electroporation cuvette is provided that includes a cuvette, first and second electrodes positioned within the cuvette and electroporation competent cells frozen in a suspension solution within the cuvette, wherein the electroporation cuvette is configured to permit electroporation of the cells when the cells are thawed. The electroporation cuvette... Agent: Molecular Transfer, Inc.

  
06/14/2012 > 114 patent applications in 65 patent subcategories. invention type

20120149003 - Nerve graft: A nerve graft includes a lyophobic substrate, a carbon nanotube film structure, a protein layer, and a nerve network. The carbon nanotube film structure is located on a surface of the lyophobic substrate. The protein layer is located on a surface of the carbon nanotube film structure away from the... Agent: Tsinghua University

20120149004 - Blood collection devices containing blood stabilization agent: Disclosed are devices for collecting and stabilizing blood that contain a blood stabilization agent which includes variegin or an analog thereof, a polysulfated disaccharide, or a combination thereof, each in an amount effective to stabilize blood. Methods of making and using the devices, and kits containing the devices, are also... Agent: Becton, Dickinson And Company

20120149005 - Reaction treatment device and reaction treatment method: Disclosed herein is a reaction treatment device including a temperature control section which includes a first temperature control section disposed at an outer peripheral edge part of a group of reaction regions and a planar second temperature control section, wherein the first temperature control section and the second temperature control... Agent: Sony Corporation

20120149010 - Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions: The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with reduced or no contaminating baculoviral virions.... Agent: Genethon

20120149006 - Cellulose substrates, compositions and methods for storage and analysis of biological materials: wherein X and Y are independently N—O-L-A or O, with the proviso that when Y is O, then X is N—O-L-A, and when X is O, then Y is N—O-L-A; L is a direct bond, an aliphatic radical, an aromatic radical, a cycloaliphatic radical, or a combination thereof; and A=COOH,... Agent: General Electric Company

20120149008 - Chromatographic system for nucleic acid detection: The present disclosure provides a strip for separation and sequence specific detection of nucleic acids in a sample, a system for sequence specific detection of nucleic acids comprising the strip of the present disclosure and an epifluorescence detection device, and a method for qualitative and/or quantitative determination of a nucleic... Agent:

20120149007 - Method for detecting analytes: The invention provides an improved method for sensitive and specific detection of target molecules, cells, or viruses. The inventive method uses large area imaging to detect individual labeled targets complexed with a target-specific selection moiety. The invention eliminates wash steps through the use of target-specific selection through one or more... Agent: Straus Holdings Inc.

20120149011 - Method for detecting target nucleic acids: The invention relates to a method for detecting target nucleic acids which are detected by means of a specific sequence tag which is not part of the target nucleic acid.... Agent: Qiagen Gmbh

20120149009 - Vaporization device and method for imaging mass spectrometry: Methods and apparatus for analyzing samples are disclosed. The samples are analyzed by vaporizing molecules from a sample in a sample area with a femtosecond laser beam under ambient conditions, ionizing the vaporized molecules with electrospray ionization under the ambient conditions to form ions; and analyzing and detecting the ions.... Agent:

20120149018 - Detection of small nucleic acids: The present invention relates to compositions and methods for the detection and characterization of interfering RNAs such as micro RNAs (miRNAs) and small interfering RNAs (siRNAs) and other short nucleic acid molecules. More particularly, the present invention relates to improved methods for the detection and quantitation of interfering RNA expression.... Agent: Third Wave Technologies, Inc.

20120149017 - Diagnostic markers of human female infertility: The subject invention pertains to methods and reagents for the diagnosis of female infertility, prognostic indicators for female infertility, compounds for the treatment of female infertility, compounds and methods for contraception. Methods and compounds are based on the levels of ebaf in endometrial tissue. Methods for diagnosing endometrial receptivity and... Agent: University Of South Florida

20120149012 - Dna methylation detection methods: The present teachings provide DNA methylation quantification methods that avoid bisulfite treatment of DNA. Methylation-specific binding proteins (MeDNA binding proteins) and non-methylation specific binding proteins (non-MeDNA binding proteins) are employed in various embodiments to modulate the accessibility of nucleic acids to primer extension reactions. After selectively removing the target nucleic... Agent: Life Technologies Corporation

20120149016 - Genetic variants in the tcf7l2 gene as diagnostic markers for risk of type 2 diabetes mellitus: Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes.... Agent: Decode Genetics Ehf.

20120149014 - Methods for obtaining fetal genetic material: The present invention relates to a method of enriching fetal nuclei from a sample. Enriched fetal nuclei can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing.... Agent: Genetic Technologies Limited

20120149013 - Methods of evaluating cells and cell cultures: Methods of evaluating the composition of a cell culture (e.g., to distinguish chondrocytes from fibroblasts) and methods for evaluating the phenotype of an individual cell (e.g., as a chondrocyte) are disclosed. The methods may be used, for example, for assessing chondrocyte cultures used for treatment of cartilage defects. In some... Agent: Genzyme Corporation

20120149015 - Soybean plant and seed corresponding to transgenic event mon87701 and methods for detection thereof: The present invention provides a transgenic soybean event MON87701, and cells, seeds, and plants comprising DNA diagnostic for the soybean event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for said soybean event in a biological sample, probes and primers for use in detecting nucleotide sequences that... Agent:

20120149019 - Use of a bis-maleic anhydride cross-linking agent for fixation of a cell or tissue sample: The present disclosure relates to novel bis-maleic anhydrides and to the surprising discovery that bis-maleic anhydride cross-linking agents can be used for preservation/fixation of a cell or tissue sample. Various bis-maleic anhydride cross-linking agent scan be used in methods requiring fixation of a cell or tissue sample. These reagents and... Agent: Roche Diagnostics Operations, Inc.

20120149022 - Compositions and methods for diagnosis and prognosis of colorectal cancer: Certain embodiments of the present invention provide methods and compositions related to the detection of colorectal cancer based upon the identification of biomarkers and combinations of biomarkers that indicate the present of colorectal cancer. One embodiment of the present invention provides a method for detecting colorectal cancer in a subject... Agent:

20120149024 - Cotton event mon 88913 and compositions and methods for detection thereof: The present invention provides a cotton plant event MON 88913 compositions and seed. Also provided are assays for detecting the presence of the cotton plant event MON 88913 based on a DNA sequence and the use of this DNA sequence as a molecular marker in a DNA detection method.... Agent:

20120149021 - Device for filtration of fluids therethrough and accompanying method: A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent.... Agent: Children's Medical Center Corporation

20120149023 - Engineered demeter 5-methylcytosine dna glyosylase with improved yield, stability and solubility: Improved active DEMETER polypeptides with internal deletions are provided.... Agent: The Regents Of The University Of California

20120149026 - Insulin resistance marker: It is provided an insulin resistance marker, a method of evaluating insulin resistance, a method of screening a substance that improves insulin resistance, and a pharmaceutical composition for improving insulin resistance. An insulin resistance marker including a polypeptide comprising at least any 15 continuous amino acids in the specific amino... Agent: Shimadzu Corporation

20120149027 - Method for determining the risk of metastasis as an indicator for diagnostic imaging: The present invention pertains to the field of in vitro diagnostics and relates to a method for determining the risk of metastasis of a tumor, wherein a high risk of metastasis shows that subsequent examinations by means of imaging methods are indicated for the patient.... Agent: Siemens Healthcare Diagnostics Inc.

20120149025 - Screening methods for human embryonic stem cells: This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described here, the role of feeder cells is replaced by components added to... Agent: Geron Corporation

20120149020 - Thermocooler for thermocycling a sample: A sample processing apparatus includes a sample carrier receiving region configured to receive a sample carrier carrying at least one sample, at least one sample processing station that processes the at least one sample, and a thermal control system that controls thermocycling of the sample during processing of the sample... Agent: Analogic Corporation

20120149028 - Detection and visualization of the cell cycle in living cells: The present invention relates to a nucleic acid molecule encoding a polypeptide specifically binding to proliferating cell nuclear antigen (PCNA), said nucleic acid molecule comprising a nucleic acid sequence encoding the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence deviating from SEQ ID NO: 2... Agent: Ludwig-maximilians Universitat M&#xdc Nchen

20120149029 - Magnetic needle biopsy: An apparatus and method for performing biopsies in-vivo using magnetically labeled nanoparticles is disclosed. One embodiment of the apparatus is called a magnetic needle. When used in a biopsy, one embodiment of the present invention collects diseased cells in-vivo which have been tagged with magnetic nanoparticles coated with receptors for... Agent:

20120149036 - Bioassay method for antibody against thyroid-stimulating hormone receptor, measurement kit for the antibody, and novel genetically modified cell for use in the bioassay method or the measurement kit: The present invention provides a method and a kit for assaying a TSH receptor antibody, which are easy to manipulate and are safe. Specifically, the present invention provides a composition comprising a genetically modified cell forced to co-express a TSH receptor, a cyclic nucleotide responsive calcium channel, and a luminescent... Agent:

20120149035 - Modular point-of-care devices, systems, and uses thereof: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods... Agent:

20120149037 - Colorimetric sensors constructed of diacetylene materials: Colorimetric sensors for detection of an analyte are disclosed. Methods of using the colorimetric sensor and a kit for the colorimetric detection of an analyte are also disclosed.... Agent:

20120149031 - Anti-cmet antibody and its use for the detection and the diagnosis of cancer: The present invention relates to the field of prognosis and/or diagnosis of a proliferative disease in a patient. More particularly, the invention relates to antibodies capable of binding to the human cMet receptor, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise... Agent:

20120149030 - Immunoassay for thrombin detection: The invention relates to an in vitro immunoassay for quantifying thrombin in a sample comprising anti-thrombin III (AT-III) and thrombin. The method comprises the following steps: contacting the sample with a small molecule that recognizes the substrate binding site of thrombin; contacting the thrombin with a thrombin specific antibody raised... Agent:

20120149032 - Enzyme detection device: An enzyme detection device (1) for detecting the presence, in a sample, of an enzyme capable of modifying a provided substrate (10). The device (1) comprises a substrate which has a modification region (14) that is sensitive to modification by the enzyme from an unmodified state to a modified state.... Agent: Mologic Ltd.

20120149033 - Antigen binding molecules that bind egfr, vectors encoding same, and uses thereof: The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human EGFR. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such... Agent:

20120149034 - Biomarker for mental disorders including cognitive disorders, and method using said biomarker to detect mental disorders including cognitive disorders: Methods are provided that detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence. Novel biomarkers are also provided for cognitive impairment and non-psychiatric disease, as well as methods for detecting cognitive impairment using such biomarkers.... Agent: Mcbi Inc.

20120149040 - Adam12, a novel marker for abnormal cell function: The present invention provides a method, an assay and a kit for providing an indication of abnormal cell function. The present inventors describes ADAM12 as a overall general marker for abnormal cell function, and the present inventor for the first time demonstrate that ADAM12 is an important indicator of fetal... Agent:

20120149038 - Diagnosis of autism: A method for diagnosing autism in a subject is performed by determining the presence and concentration of specific peptides in the body fluid. The peptides have the amino acid sequences SKITHRIHWESASLL, SSKITHRIHWESASLL, and SSKITHRIHWESASLLR with the molecular masses 1779+/−1 Da, 1865+/−1 Da and 2022+/−1 Da, respectively.... Agent:

20120149039 - Diagnostic apparatus for organic sample analysis: A diagnostic apparatus for organic-sample analyses including a fluid sucking and ejecting device to enable suction and inner storage or ejection to the outside of the fluid, a feeding needle that can be secured to the sucking device including an inner channel for passage of the fluids and to be... Agent: Btp Tecno S.r.l.

20120149041 - Identification and quantification of biomarkers for evaluating the risk of preterm birth: Described herein are methods for evaluating the risk of preterm birth in pregnant subjects. The methods involve detecting and quantifying a first biomarker and a second biomarker associated with preterm birth in a biological sample from the subject. Also described herein are isolated biomarkers and kits useful in predicting the... Agent: Brigham Young University

20120149044 - Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine-mediated toxicity: The present invention relates to diagnostic methods for determining migration inhibitory factor (MIF) mRNA content in a sample, wherein MIF is human MIF polypeptide having a molecular weight of approximately 12.5 kDa and kits for detecting MIF.... Agent: Baxter International Inc.

20120149042 - Methods for predicting outcome in traumatic brain injury: The invention describes methods for predicting outcome for patients suffering from traumatic brain injury (TBI) by evaluating levels of markers commonly associated with cellular damage in bodily fluids. Utilization of such methods improves diagnosis and treatment of patients suffering from traumatic brain injury, thus potentially minimizing and/or eliminating long-term adverse... Agent: Nexus Dx, Inc.

20120149043 - Urinary biomarkers for cancer diagnosis: The present invention is directed to the field of cancer diagnosis, specifically to the diagnosis of bladder cancer (BC) and prostate cancer (CaP). More specifically, the invention provides simple, non-invasive urinary tests characterized by high sensitivity and specificity, wherein urinary levels of heat shock proteins and anti-inflammatory cytokines are used... Agent: Yeda Research And Development Co. Ltd.

20120149046 - Bioluminescent bacterial detection: This invention relates to bioluminescent methods for detecting specific target bacteria, such as E. coli, coliforms, Enterococcus spp, Listeria spp and S. aureus in samples. The sample to be tested is incubated in a non-selective growth medium for up to 8 hours to produce a sample culture and which is... Agent:

20120149045 - Luminescent live and dead cell assay: A method to detect live and dead cells in a sample with one bioluminogenic reagent is provided.... Agent: Promega Corporation

20120149047 - Method for quantitatively determining ldl cholesterols: A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholestrols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the... Agent: Sekisui Medical Co., Ltd.

20120149048 - Method of differentiating between blood and control solutions containing a common analyte: Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples.... Agent: Bayer Healthcare, LLC

20120149050 - Automated systems and methods for preparing biological specimens for examination: The systems and methods disclosed herein permit automated preparation of biological specimens for examination. The disclosed systems and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a biological specimen to a substrate such as... Agent: Constitution Medical, Inc.

20120149053 - Carrier peptide fragment and use thereof: A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including any amino acid sequence selected from SEQ ID Nos. 1, 2, 3, 4, 5, and 6, or an amino acid sequence formed by the... Agent: Toagosei Co. Ltd.

20120149051 - Devices for the production of cell clusters of defined cell numbers and cluster sizes: Devices for the in vitro aggregation of cells. The devices are characterized by containing special ground cavities allowing cluster formation to take place when a cell suspension is seeded onto the device. Further, the present invention relates to a method for aggregating cells and the use of the devices of... Agent:

20120149054 - Measurement method for viable cell count, and culture medium: There are provided a method of identifying the longum species alone, such as Bifidobacterium longum subsp. longum alone, and measuring the viable cell count thereof, amongst the bacterial cells to be tested which include a microorganism belonging to the genus Bifidobacterium by using a culture medium that contains L-arabinose as... Agent: Morinaga Milk Industry Co., Ltd.

20120149052 - Method for optical measuring variations of cell membrane conductance: The instant invention refers to an optical method to extrapolate cell membrane conductance by indirect measurement of changes in transmembrane voltage, upon exposure of a cell sample to electric current pulses. The method is advantageously used for evaluating the activity of molecules able to alter, directly or indirectly, membrane permeability.... Agent: Fondazione Centro San Raffaele Del Monte Tabor

20120149049 - System and method for presenting an automated assessment of a sample's response to external influences: A biological sample is evaluated by an automated apparatus that operates to identify one or more areas of interest within the sample. Each area of interest has a classifiable appearance brought about from the sample's interaction with an external influence under investigation. The apparatus classifies each area of interest by... Agent: Mbt Technology LLC

20120149055 - Paper strip for determining minimum inhibitory concentrations of antibiotics: The present invention concerns the sector of chemical, clinical, bacteriological and immunological analyses and more specifically it concerns the use of a strip of impregnated paper in order to determine, in the simplest, most economical and most accurate way, the correct Minimum Inhibitory Concentration (M.I.C.) of antibiotic molecules to be... Agent: Liofilchem S.r.l.

20120149056 - Method and reagents for detecting the presence or absence of a target substance in a test sample: Reagent mixtures and testing procedures for detecting the presence or absence of various target substances such as aureus; vancomycin-resistant enterrococcus; Group B Streptococcus; E. coli; fungi; and others, involve the use of a testing reagents which include growth factors for the particular target substance, a detectable signal generator which is... Agent: Pilots Point LLC

20120149057 - Method for prognosing response to cancer therapy with 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine: Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the cancer with a solution of TCPP to permit binding of the TCPP to components of the abnormal... Agent: Biomoda, Inc.

20120149058 - Process and apparatus for testing substances for potential carcinogenicity: An apparatus (2) for the automatic testing of substances for carcinogenicity comprises: a plate support (3) on which at least one micro-well plate (1) can be placed; a movable pipetting unit (4) comprising a predetermined number of pipettes (40); a number of containers (5) containing a liquid culture medium (50),... Agent: F. Hoffman-la Roche Ag

20120149059 - Tissue processor: A tissue processing system includes a plurality of processing stations. Each processing station includes a plurality of tissue receiving areas that are each configured to accommodate a tissue sample as well as physically isolate that tissue sample from other tissue samples at other receiving areas of the same processing station.... Agent: Rushabh Instruments, LLC

20120149060 - Nucleic acids for cloning and expressing multiprotein complexes: The present invention relates to a nucleic acid containing at least one homing endonuclease site (HE) and at least one restriction enzyme site (X) wherein the HE and X sites are selected such that HE and X result in compatible cohesive ends when cut by the homing endonuclease and restriction... Agent: Europaisches Laboratorium Fur Molekularbiologie (embl)

20120149061 - Modified antibody compositions, methods of making and using thereof: The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified.... Agent:

20120149062 - High purity lipopeptides: The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion... Agent: Cubist Pharmaceuticals, Inc.

20120149063 - Process for the culturing of cells: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to... Agent: DsmIPAssets B.v.

20120149064 - Filamentous fungi with impaired ptrb activity for altered protein production: A filamentous fungal cell is provided comprising at least one mutation, wherein the filamentous fungal cell has impaired ptrB activity and has altered expression of a protein of interest as compared to a corresponding parent filamentous fungal cell. In one embodiment, the altered expression of the protein of interest is... Agent: Danisco US Inc.

20120149065 - Use of manganese peroxidase for enzymatic hydrolysis of lignocellulosic material: Improved manganese peroxidases, polynucleotides encoding improved manganese peroxidase and vectors and cells thereof are provided, as well as methods for converting a cellulose-containing biomass feedstock to ethanol using improved manganese peroxidases and cells expressing a heterologous manganese peroxidase as disclosed herein.... Agent: Edeniq, Inc.

20120149066 - Method for producing glucosamine by culturing microorganism with low-cost medium: A method for producing glucosamine with microorganism comprises of fermenting with a microorganism selected from the group consisting of Monascus pilosus and Aspergillus sp. in a novel low-cost medium, thereby enable it to produce glucosamine; wherein said medium is consisted of commercial Taiwan sugar, soy beam, rice bran and the... Agent: Yuan Ze University

20120149067 - Methods for producing hyaluronan in a recombinant host cell: The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a Bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein the Bacillus host cell comprises a nucleic acid construct comprising a hyaluronan synthase encoding sequence operably linked to a promoter sequence foreign... Agent: Novozymes, Inc.

20120149068 - Methods and compositions for amplification of rna sequences: The invention provides methods for isothermal amplification of RNA. The methods are particularly suitable for amplifying a plurality of RNA species in a sample. The methods employ a composite primer, a second primer and strand displacement to generate multiple copies of DNA products comprising sequences complementary to an RNA sequence... Agent: Nugen Technologies, Inc.

20120149069 - Methods and compositions for seamless cloning of nucleic acid molecules: The present invention is in the fields of biotechnology and molecular biology. More particularly, the present invention relates to cloning or subcloning one or more nucleic acid molecules comprising one or more type IIs restriction enzyme recognition sites. The present invention also embodies cloning such nucleic acid molecules using recombinational... Agent: Life Technologies Corporation

20120149070 - Variants of glucoamylase: The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DNA constructs... Agent: Danisco A/s

20120149071 - D-aminoacylase: A D-aminoacylase produced by a microorganism of genus Defluvibacter; which acts on a N-acetyl-D-amino acid; which has a molecular weight (as determined by electrophoresis) of about 55,000 daltons, and an isoelectric point (as determined by two-dimensional electrophoresis for denatured system) of 5.3; which acts on N-acetyl-D-valine, N-acetyl-D-leucine, and the like,... Agent: Daiichi Pure Chemicals Co., Ltd.

20120149072 - Method for producing basic substance: A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter... Agent:

20120149073 - Ketoreductase polypeptides for the preparation of phenylephrine: The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.... Agent: Codexis, Inc.

20120149075 - Soaps produced from oil-bearing microbial biomass and oils: Soap and cosmetic products can be made from oil-bearing microbial biomass via the alkaline hydrolysis of glycerolipids and fatty acid esters to fatty acid salts. The saponified microbial oils/lipids can be combined with a variety of additives to produce compositions for use as soaps and other cosmetic products, which may... Agent: Solazyme, Inc.

20120149074 - Transformant comprising gene coding for ws/dgat and method of producing fatty acid ethyl esters using the same: The present invention relates to a transformant comprising a gene encoding ws/dgat (wax ester synthase/acyl-coenzyme A: diacylglycerol acyltransferase) and a method of producing fatty acid ethyl esters using the same. Specifically, the transformant for producing fatty acid ethyl esters is constructed such that glycerol is used as a fermentation substrate,... Agent: Korea University Research And Business Foundation

20120149076 - Integration of fermentaiton with membrane: Herein disclosed is a method comprising a) fermenting biomass to produce a fermentation broth; b) separating the fermentation broth into a liquid stream and a solid or slurry stream; c) passing the liquid stream through a reverse osmosis membrane to obtain a permeate and a retentate; and d) concentrating the... Agent: Terrabon Mix-alco, Inc.

20120149077 - Mesophilic and thermophilic organisms modified to produce acrylate, and methods of use thereof: The present invention provides for novel metabolic pathways leading to acrylate formation in a consolidated bio-processing system (CBP) where lignocellulosic biomass is efficiently converted to acrylate. In one such metabolic pathway, pyruvate is converted to lactate, which is converted to lactoyol-CoA, which is converted to acryloyl-CoA, and which is finally... Agent: Mascoma Corporation

20120149078 - Polypeptides having acetylxylan esterase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having acetylxylan esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20120149079 - Polypeptides having c4 dicarboxylic acid transporter activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having C4-dicarboxylic acid transporter activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, and methods of producing C4-dicarboxylic acids, such... Agent: Novozymes, Inc.

20120149080 - Yeast production culture for the production of butanol: High cell density cultures of yeast were found to have higher tolerance for butanol in the medium. The high cell density yeast cultures had greater survival and higher glucose utilization than cultures with low cell densities. Production of butanol using yeast in high cell density cultures is thus beneficial for... Agent: Butamax(tm) Advanced Biofuels LLC

20120149081 - Method for fermentation culture in medium containing xylose: The xylose-metabolizing ability and particularly the xylose incorporation rate, of yeast to which xylose-metabolizing ability has been imparted are significantly improved. The method according to the present invention comprises the steps of: culturing yeast having xylose-metabolizing ability in a xylose-containing medium in which the concentration of at least one amino... Agent: Toyota Jidosha Kabushiki Kaisha

20120149084 - Fusion proteins: The invention provides a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a target cell; a Targeting Moiety that is capable of binding to a Binding Site on... Agent: Syntaxin, Limited

20120149085 - Fusion proteins containing recombinant cytotoxic rnases: Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse fused to the N-terminus of one antibody variable domain can be prepared and retain the ability to specifically bind antigen. The immunotoxins may be... Agent: Immunomedics, Inc.

20120149082 - Method for the preparation of cross-linked enzyme aggregates with improved properties: The invention relates to a method for the preparation of hybrid cross-linked enzyme-silica aggregates including the steps of taking up enzyme molecules in a solvent, precipitating the enzyme molecules using a precipitation agent, and adding an alkoxysilane and crosslinking the mixture of alkoxysilane and precipitated enzyme aggregates, using a crosslinking... Agent:

20120149083 - Peg-urate oxidase conjugates and use thereof: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and... Agent: Mountain View Pharmaceuticals, Inc.

20120149086 - Cutinase-producing genetically engineered microorganism and use thereof: The present invention relates to the field of bioengineering and discloses a cutinase-producing genetically engineered microorganism and use thereof. Recombinant plasmid Tfu_0883-hlyAs/pET20b(+) was constructed and transformed into E. coli BL21(DE3) to obtain recombinant E. coli strain Tfu_0883-hlyAs/pET20b(+)/E. coli BL21(DE3). Specific growth rate was maintained at a certain value using fed-batch... Agent: Jiangnan University

20120149087 - Glucoamylase variants with altered properties: The present disclosure relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present disclosure provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions and cleaning compositions. The disclosure also relates to DNA constructs encoding the variants and methods of... Agent: Danisco US Inc.

20120149088 - Alkylene glycols and polymers and copolymers thereof for direct isolation of nucleic acid from embedded samples: Methods of directly isolating nucleic acid from an embedded biological sample are provided. An emulsified digest is generated in the presence of a thermostable protease, and an additive selected from an alkylene glycol, a poly(alkylene glycol), or a block copolymer having an average Mn of 76 to 2900, or a... Agent: Life Technologies Corporation

20120149089 - Animal product free system and process for purifying a botulinum toxin: Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.... Agent: Allergan, Inc.

20120149090 - Cell for preparing competent cell, method for preparing competent cell and bacterial strain of escherichia coli: The invention provides a cell for preparing competent cells, wherein the cell is capable of spontaneously accumulating self-producing trehalose therein and the cell is used for the preparation of competent cells. The invention also provides a method for preparing competent cells, including: culturing the cell for preparing the competent cell... Agent:

20120149091 - Systems, devices, and methods for biomass production: Systems, devices, and methods for cultivating biomasses. A bioreactor system is operable for growing photosynthetic organisms. The bioreactor system includes a bioreactor and a lighting system. The lighting system includes one more light-emitting substrates configured to light at least some of a plurality of photosynthetic organisms retained in the bioreactor.... Agent:

20120149092 - Ethanol production in microorganisms: The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium.... Agent: Joule Unlimited Technologies, Inc.

20120149093 - Method and apparatus for automating chemical and biological assays: A device which collects specimen fluids or performs chemical or biological assays of the specimen fluid is provided with a specimen fluid receiver and a fluid actuated expandable trigger coupled to receive specimen fluid from the specimen fluid receiver such that a predetermined delay occurs before the trigger expands sufficiently... Agent:

20120149094 - Biological sterilization indicator and method of using same: A biological sterilization indicator (BI) and a method of using same for assaying the lethality of a sterilization process. The BI can include a housing, which can include a first portion, and a second portion, which can be movable with respect to the first portion between a first and second... Agent:

20120149095 - Dna promoters and anthrax vaccines: The invention is related to intracellularly induced bacterial DNA promoters and vaccines against Bacillus anthracis.... Agent: The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Srvcs

20120149097 - Nonviral vectors for delivering polynucleotides to target tissue: Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal.... Agent: Gencia Corporation

20120149096 - Prrs viruses, infectious clones, mutants thereof, and method of use: The present invention provides isolated infectious polynucleotides, such as infectious clones, having a nucleotide sequence with identity to PRRS viruses such as VR-2332, Lelystad, or others, and optionally further including a deletion in a region of ORF1 that encodes the nsp2 polypeptide.... Agent: Regents Of The University Of Minnesota

20120149100 - Cardiomyocyte cell populations: The present invention provides methods for inducing the differentiation of cardiac progenitor cells and cell populations produced by the methods of the invention. The invention further provides a method of screening for agents that affect cardiomyocytes, and a method of cardiomyocyte replacement therapy.... Agent: Mount Sinai School Of Medicine

20120149099 - Differentiation process of mesenchymal stem cells and therapeutic use thereof: Process for inducing differentiation of mesenchymal stamina cells into neuroblasts and/or neurons that envisions the use of a differentiation solution consisting of retinoic acid and ethanol.... Agent: Davide Vannoni

20120149098 - Extraction of process for mesenchymal stromal stem cells: Mesenchymal stromal stem cells are obtained starting with a biopsy sample from the iliac crest of the pelvis that is fragmented with surgical forceps in a saline solution and the saline solution containing the pulverised biopsy sample is then subjected to centrifugation, so to obtain mesenchymal stromal stem cells. The... Agent: Davide Vannoni

20120149101 - Methods and kits for regulating intracellular trafficking of a target protein: A method and kits for regulating the intracellular trafficking of a target protein. In a retained state, the target protein is retained in a first compartment by an interaction with a hook protein. In a released state, the interaction is disrupted and the target protein traffics to a target compartment.... Agent: Institut Curie

20120149102 - Agonist and antagonist peptides of carcinoembryonic antigen (cea): The invention provides a polypeptide comprising an agonist of a MHC Class I binding native sequence having amino acid substitution(s) and enhanced immunogenicity compared to the native sequence. The invention provides DNA encoding the polypeptide, as well as vectors and cells comprising the DNA and methods comprising the administration of... Agent: The United States Of America, As Represented By The Secretary, Department Of Health And

20120149103 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.

20120149104 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.

20120149105 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.

20120149106 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.

20120149107 - Process for the culturing of cells: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to... Agent: DsmIPAssets B.v.

20120149108 - Cell preservation method: A method for cryopreservation of cells characterized by the use of a solution containing, as essential components, a sodium salt, a potassium salt, a saccharide, a cryoprotectant, and a hydrogencarbonate salt and/or a carbonate salt, the solution further optionally containing a component selected from the group consisting of proteins, magnesium... Agent:

20120149109 - Modulation of transthyretin expression: Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.... Agent: Isis Pharmaceuticals, Inc.

20120149110 - Process for production of bioartificial organ: A method for inducing the differentiation of stem cells into tissue cells; a bioartificial organ, which contains the tissue cells; and a material for medical purposes, which contains the bioartificial organ are disclosed. Stem cells capable of proliferation, self-replication and differentiation are used and cultured by a hanging-drop method to... Agent: Organ Technologies Inc.

20120149111 - Porous polymer scaffolds for neural tissue engineering and methods of producing the same: The present invention relates to scaffolds that can physically guide cells, e.g. neurons, while best matching the material properties of native tissue. The present invention also relates to methods of generating such scaffolds, and for the use of such scaffolds, e.g. in spinal cord and peripheral nerve injury repair. The... Agent: Drexel University

20120149112 - Method for making nerve graft: A method for making a nerve graft includes the following steps. A culture layer including a lyophobic substrate, a carbon nanotube film structure, and a protein layer is provided. The carbon nanotube film structure is sandwiched between the lyophobic substrate and the protein layer. A number of nerve cells are... Agent: Tsinghua University

20120149113 - Method for making nerve graft: A method for making a nerve graft includes the following steps. A culture layer including a carbon nanotube film structure and a protein layer is provided. The protein layer is located on a surface of the carbon nanotube film structure. A number of nerve cells are seeded on a surface... Agent: Tsinghua University

20120149114 - Methods for cell culture using a synthetic, defined collagen mimetic surface: The present invention discloses methods for enhancing cell attachment, cell proliferation and cell function using a surface which mimics a collagen coated surface. Advantageously, such methods employ a xeno-free, synthetic, chemically defined surface.... Agent: Becton, Dickinson And Company

20120149115 - Targeted genomic rearrangements using site-specific nucleases: The present invention relates to a method for genomic DNA rearrangements, and more particularly, to a method for deletion, duplication, inversion, replacement, or rearrangement of genomic DNA using pairs of site-specific nucleases targeting two or more sites in the genome, a cell in which genomic DNA is deleted, duplicated, inverted,... Agent: Toolgen Incorporation

20120149116 - Cellulose degradable yeast and method for production thereof: The present invention provides a method for producing a cellulose degradable yeast, comprising the step of co-introducing genes coding for at least two cellulose-degrading enzymes into a yeast host via integration with a yeast δ sequence. According to the invention, a yeast having an improved cellulose degradation ability are provided.... Agent: Kansai Chemical Engineering Co., Ltd.

  
06/07/2012 > 138 patent applications in 70 patent subcategories. invention type

20120141973 - Perfusion and/or preservation solution for organs: The present invention relates to a solution for preservation, perfusion, and/or reperfusion of an organ, especially the heart, for transplantation. The solution contains peptide inhibitor(s) of protein kinase C βII (PKC βII) and/or of protein kinase C ζ (PKC ζ) and/or peptide activator(s) of protein kinase C δ (PKCδ). Methods... Agent: Philadelphia College Of Osteopathic Medicine

20120141975 - Blood component separation system and separation material: The present invention relates to a separation system and a separation material for easily and rapidly separating a red blood cell-rich fraction, a white blood cell-rich fraction, and/or a platelet-rich fraction from a biological fluid containing these blood cell components without the necessity of performing centrifugation. The separation of a... Agent: Kaneka Corporation

20120141974 - Cryopreservation of human red blood cells: A red blood cell storage composition includes a composition of red blood cells and biochemistry altering reagents, the biochemistry altering reagents being present at a concentration so as to reduce the percent hemolysis of the red blood cells during the freeze-thaw cycle below that of the percent hemolysis of the... Agent: Lifecell Corporation

20120141977 - Hepatitis b virus mutation strain with resistance to adefovir dipivoxil and the uses thereof: A HBV mutation strain is provided, wherein rtE218G mutation occurs at the polymerase region of the mutation strain. The use of the HBV strain in screening anti-HBV drugs and related detection reagents used to detect rtE218G mutation are also provided.... Agent: Peking University People's Hospital

20120141976 - Method for detecting viable cells in a sample by using a virus: A method for detecting viable cells such as bacterial cells, within a sample, said method comprising (i) incubating said sample with a virus which is able to infect said cells under conditions which allow said virus to infect and replicate within any such cells which are viable; and (ii) detecting... Agent: Enigma Diagnostics Ltd

20120141980 - Method for isolating viruses: The present invention relates to a method and kit for the isolation of viruses from a sample. The sample is treated with an extraction solution that comprises at least a divalent chloride salt and/or an ionic liquid.... Agent: Merk Patent Gesellschaft Mit Beschrankter Haftung

20120141979 - Oligonucleotides for detecting chicken astrovirus: There is provided an oligonucleotide sequence capable of binding to a portion of a CAstV genome, wherein the oligonucleotide sequence has binding specificity to the precapsid region of CAstV or to cDNA of the precapsid region. The oligonucleotide sequence can be one of a primer pair for use in a... Agent:

20120141978 - Prrsv gp5 based compositions and methods: The disclosure includes compositions and methods for the production of an immune response against porcine reproductive and respiratory syndrome (PRRS) virus, or PRRSV. The disclosure is based in part on the use of two or more peptide domains, each with a different sequence, from the PRRSV GP5 protein ectodomain. Compositions... Agent: Mj Biologics, Inc.

20120141982 - Culture method for obtaining a clonal population of antigen-specific b cells: The present invention relates to methods of isolating antigen-specific cells and producing antibodies therefrom.... Agent:

20120141984 - Methods of isolating stem cells: The present inventors discovered for the first time that labeling cell nuclei makes it possible to efficiently isolate stem cells. Namely, it was elucidated that stem cells with labeled nuclei remained labeled even after cell division, and showed self-renewing and long-living abilities characteristic of stem cells. Efficient isolation of stem... Agent: Stelic International, Inc.

20120141983 - Quantitative aggregation sensors: Composition, systems and methods are provided for quantifying the amount of protein aggregation occurring in a cell in vitro and in vivo. These compositions, systems and methods find use in a number of applications, including in screening candidate agents for activity in modulating intracellular and extracellular protein aggregation in vitro... Agent:

20120141985 - Real-time monitoring of depletion of high-abundance blood proteins or recovery of low-abundance blood proteins by uv spectrometry: Disclosed is a method for monitoring depletion of high-abundance and/or recovery of low-abundance proteins from blood in real time, comprising: (a) labeling high-abundance and/or low-abundance proteins of a blood specimen with a fluorescent or UV marker; and (b) passing blood samples containing the fluorescent or UV marker-labeled high-abundance and/or low-abundance... Agent: Snu R&db Foundation

20120141981 - Second harmonic imaging nanoprobes and techniques for use thereof: Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an... Agent:

20120141998 - Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance: The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to... Agent: Georgia Health Sciences University

20120141997 - Compositions and methods for free-solution conjugate nucleic acid analysis: The present invention provides compositions and methods for performing free-solution conjugate analysis of nucleic acid molecules. For example, the present invention provides multiplexed single-base extension assays for genotyping. In particular, the present invention provides a series of disperse polyamide “drag tags” for use in achieving high-resolution separation of nucleic acid... Agent: Northwestern University

20120141993 - Compositions and methods for neisseria gonorrhoeae diagnostic testing: The invention provides methods, reagent, and kits for detecting the presence of Neisseria gonorrhoeae in a test sample.... Agent: Program For Appropriate Technology In Health

20120141992 - Compositions and methods for trichomonas vaginalis diagnostic testing: The invention provides methods, reagents and kits for determining the presence of Trichomonas vaginalis in a test sample.... Agent: Program For Appropriate Technology In Health

20120141996 - Cystic fibrosis transmembrane conductance regulator gene mutations: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further... Agent: Quest Diagnostics Investments Incorporated

20120141989 - Kit and method for rapidly detecting a target nucleic acid fragment: The invention provides a kit for rapidly detecting a target nucleic acid fragment comprising a magnetic bead; an inner primer pair and an outer primer pair suitable for loop-mediated isothermal amplification; and reagents for loop-mediated isothermal amplification. The invention also provides a kit for detecting a pathogen in fish, a... Agent: National Cheng Kung University

20120141987 - Method and probes for the detection of cancer: Probe sets and methods of using probes and probe sets for the detection of cancer are described. Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if cancer cells are present the sample. Also included are methods... Agent:

20120141995 - Method for the detection of multiple single nucleotide variations or single nucleotide polymorphisms in a single tube: The present invention discloses a method for detecting multiple single nucleotide variations or polymorphisms in a single reaction tube, and the oligonucleotide, the probe, the set of probes, the kit used, as well as the use thereof. Specifically, it relates to a method for identifying the genotype of multiple single... Agent: Xiamen University

20120141988 - Method of cell-line identification: The present invention discloses a method of cell-line identification comprising one or more of the following steps: (a) analysis of the calmodulin gene; (b) analysis of the Axl receptor tyrosine kinase gene; (c) analysis of an attacin gene; or a combination thereof.... Agent:

20120141994 - Methods and compositions for prognosing and detecting age-related macular degeneration: The invention provides methods and compositions for determining whether a subject is at risk of developing age-related macular degeneration, for example, the wet or neovascular form of age-related macular degeneration. The method involves determining whether the subject has a protective variant and/or a risk variant at a polymorphic site in... Agent:

20120141991 - Methods and probes for detecting esophageal cancer: Probe sets and methods of using probes and probe sets for selectively detecting high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia from biologic samples are described. Methods of the invention include contacting a biological sample obtained from a subject with a set of chromosomal probes to selectively detect... Agent:

20120141990 - Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria: The present invention relates generally to detection of antibiotic-resistant bacteria in a sample. In particular, the invention provides methods, compositions and kits for detecting and analyzing methicillin-resistant Staphylococcus aureus (MRSA) and other methicillin-resistant bacteria in a sample.... Agent: Molecular Detection, Inc.

20120141986 - Multivalent substrate elements for detection of nucleic acid sequences: The invention provides a method of detecting multiple nucleic acid sequences using multiplex substrate elements, each having predetermined sets of independent probes, and using mistures of distinguishably labeled nucleotides.... Agent:

20120142012 - Biomarker for colorectal cancer: The present invention relates to new methods for predicting the clinical outcome or determining the treatment course in a subject afflicted with solid tumors, like colorectal cancer, and for monitoring the progression of solid tumors, like colorectal cancer, in a subject. Moreover, the present invention relates to a method for... Agent:

20120142009 - Compositions and methods for preventing or treating inflammatory bowel disease: Compositions comprising docosahexaenoic acid (DHA) and optionally one or more fatty acids selected from the group consisting of eicosapentaenoic acid (EPA), arachidonic acid (ARA), linoleic acid (LA), and α-linoleic acid (ALA) are administered to felines for preventing or treating feline inflammatory bowel disease (IBD).... Agent: Hill's Pet Nutrition, Inc.

20120141999 - Gene analysis apparatus and gene analysis method using the same: A gene analysis apparatus includes a sample preparation chip in which a polymerase chain reaction (“PCR”) sample is prepared, a PCR chip in which a PCR is performed on the PCR sample, and a package layer on which the sample preparation chip and the PCR chip are mounted. The package... Agent: Samsung Electronics Co., Ltd.

20120142006 - Massive parallel method for decoding dna and rna: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise... Agent: The Trustees Of Columbia University In The City Of New York

20120142001 - Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom: A method for extracting nucleic acids from a biological sample by isolating nucleic acid-containing particles from the biological sample by one or more centrifugation procedures, performing one or more steps to mitigate adverse factors that prevent or might prevent high quality nucleic acid extraction, and extracting nucleic acids from the... Agent: Exosome Diagnostics, Inc.

20120142005 - Method for screening of regenerative medicine: A method for screening for a substance capable of regulating the regeneration, proliferation or differentiation of a cell or an organ, which comprises the steps of: (1) allowing a cell having a regenerative, proliferative or differentiative capability to form an embryoid body; (2) treating the embryoid body produced in step... Agent: Takeda Pharmaceutical Company Limited

20120142000 - Methods and compositions for assessment of pulmonary function and disorders: The present invention is concerned with methods for the assessment of pulmonary function and/or disorders, and in particular for diagnosing predisposition to and/or severity of chronic obstructive pulmonary disease in smokers and non-smokers usins analysis of genetic polymorphisms and altered gene expression, particularly with regard to genes involved in matrix... Agent: Auckland Uniservices Ltd.

20120142008 - Methods for evaluating gastrointestinal absorption of chemicals: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing... Agent: Absorption Systems Group, LLC

20120142010 - Microfabricated integrated dna analysis system: Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cycling chambers. A microreactor element may include a microcarrier element carrying the multiple copies of the... Agent: The Regents Of The University Of California

20120142011 - Modified sina: The present invention pertains to the use of at least one abasic modification within the first 8 nucleotide positions of the 5′ region of the antisense strand of a small interfering nucleic acid (siNA) molecule for reducing off-target effects. Provided are suitable modified siNAs, compositions and methods for producing respective... Agent: Qiagen Gmbh

20120142002 - Spontaneously immortalized multicomponent mesenchymal cell-line derived from mouse subcutaneous adipose tissue: tool for regenerative medicine and bioactive molecules and/or drugs screening: Disclosed is a spontaneously immortalized multipotent mesenchymal cell-line, wherein the cell-line has been isolated from mouse subcutaneous adipose tissue, and wherein the cell-line presents fibroblastoid morphology and expresses Sca-1, c-Kit/CD117, nestin, nucleostemin, CD44 and CD106 markers.... Agent: Universita Degli Studi Del Piemonte Orientale "amedeo Avogadro"

20120142007 - Stable compositions for nucleic acid amplification and sequencing: The present invention is directed to compositions comprising mixtures of reagents, including thermostable enzymes (e.g., thermostable DNA polymerases), buffers, cofactors and other components, suitable for immediate use in nucleic acid amplification or sequencing techniques without dilution or addition of further components. The compositions contain no stablizing agents (e.g., glycerol or... Agent: Life Technologies Corporation

20120142003 - Trichomonas vaginalis testing using tv5.8s as a target: The invention provides methods, reagents and kits for determining the presence of Trichomonas vaginalis in a test sample.... Agent: Program For Appropriate Technology In Health

20120142004 - Universal tags with non-natural nucleobases: The present invention relates to amplification primers with a universal tag and sequencing primers comprising at least one non-natural nucleobase capable of hybridizing to a complementary non-natural nucleobase. The present invention further relates to amplification methods of nucleic acid amplification and sequencing using an amplification primer with a universal tag... Agent: Siemens Healthcare Diagnostics Inc.

20120142013 - Nucleic acid aptamer capable of binding specifically to pancreatic cancer cells or tissues and use thereof: The present invention relates to a nucleic acid aptamer which can specifically recognize and bind to pancreatic cancer cells or tissues. The nucleic acid aptamer can bind specifically only to pancreatic cancer cells or tissues without binding to normal pancreatic cancer tissue, and thus can be effectively used as a... Agent: Sungkyunkwan University Foundation For Corporate Collaboration

20120142014 - Molecular indicia of cellular constituents and resolving the same by super-resolution technologies in single cells: Methods and systems are provided for creating molecular barcodes or indicia for cellular constituents within single cells and for resolving such barcodes or indicia with super resolution technologies such as super resolution microscopy. By this approach, numerous molecular species that can be measured simultaneously in single cells. It has been... Agent: California Institute Of Technology

20120142015 - Gfp fusion proteins and their use: The present invention provides fusion proteins including a green fluorescent protein inserted into the internal amino acid sequence of a Gαs protein and further provides method of using the fusion protein construct to follow activation of a G-protein receptor by a candidate drug.... Agent: The Board Of Trustees Of The University Of Illinois

20120142016 - Array-based bioactivated nanopore devices: A nanopore device capable of single molecule detection is described. The nanopores are formed in thin, rigid membranes and modified by a sputtered metal that forms an overhang during application. The overhang causes the pore to be narrower in a certain region, allowing passage of only a single molecule through... Agent: The Board Of Trustees Of The Leland

20120142017 - Biosensor device and manufacturing method thereof: Disclosed is a biosensor device, comprising: a capillary tube with probe molecules immobilized on the inner wall surface thereof, and a liquid sample containing target molecules, said biosensor device being characterized in that a contact angle between the inner wall surface of the capillary tube and the liquid sample changes... Agent: Electronics And Telecommunications Research Institute

20120142022 - Glycosylated mammalian ngal and use thereof: The present invention relates to glycosylated mammalian NGAL, and methods of using said glycosylated mammalian NGAL.... Agent: Abbott Laboratories

20120142021 - Ph modulation methods and systems for detecting binding events: Methods and systems for detecting binding between first and second molecules using a pH-sensitive fluorophore. A change in fluorescence emission intensity of the fluorophore is indicative of binding.... Agent: The Texas A&m University System

20120142018 - Rapid single cell based parallel biological cell sorter: A disposable rapid cell sorter comprises of microfluidic chip with electrodes and sorts biological cells of interest through magnetic field and electric field based on biological cell functional antibody bonded magnetic beads and luminescent labeling.... Agent:

20120142019 - Sample metering device and assay device with integrated sample dilution: In one embodiment, the invention is to a sample metering device, comprising a sample holding chamber oriented between a sample entry port and a sample isolation unit and having a diluent introduction port disposed therebetween for introduction of a diluent into the sample holding chamber. The volume within the sample... Agent: Abbott Point Of Care Inc.

20120142020 - Sample metering device and assay device with integrated sample dilution: In one embodiment, the invention is to a sample metering device, comprising a sample holding chamber oriented between a sample entry port and a sample extraction unit, wherein a portion of said extraction unit defines a metered volume of a sample. A diluent may be transported over and/or through the... Agent: Abbott Point Of Care Inc.

20120142028 - Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors: The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. These methods are based on the surprising discovery that the effectiveness of treatment with an EGFR kinase inhibitor is predicted by whether a patient's tumor cells express a high... Agent: Osi Pharmaceuticals, LLC

20120142027 - Compositions and methods for modulating the immune response and identifying immunomodulators: The present invention provides compositions and methods for the identification of immunomodulators. The invention further provides an isolated complex comprising an UNC93B polypeptide and an UNC93B-dependent TLR polypeptide and methods of use thereof. The invention further provides methods of modulating immune system activity and methods of treating diseases characterized by... Agent: Whitehead Institute For Biomedical Research

20120142029 - Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.... Agent: The Regents Of The University Of California

20120142030 - Biomarkers for follicular thyroid carcinoma and methods of use: The present invention provides protein biomarkers for determining whether a thyroid nodule is malignant or benign and methods for using the same.... Agent: The Regents Of The University Of Colorado, Body Co Rporate

20120142032 - Multi-frequency impedance method and apparatus for discriminating and counting particles expressing a specific marker: An analysis method for identifying and counting particles expressing a specific antigenic marker is proposed. One example (but not exclusive) is CD4+ T-lymphocyte analysis in blood. The method comprises obtaining a sample comprising particles in suspension, labeling the particles expressing the specific marker with an impedance label, and measuring the... Agent: Koninklijke Philips Electronics N.v.

20120142031 - Real time electronic cell sensing systems and applications for cell-based assays: The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In... Agent:

20120142023 - Proteins and method for detection of lyme disease: Recombinant B. burgdorferi proteins, representative of the life cycle, are membrane-immobilized to capture antibodies in biological samples. Lateral flow technology incorporating gold colloid deposition results in band visualization indicative of a positive test.... Agent:

20120142026 - Assay devices with integrated sample dilution and dilution verification and methods of using same: The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the... Agent: Abbott Point Of Care Inc.

20120142024 - Means and methods for the determination of the amount of neurotoxin polypeptide and of its catalytic and proteolytic activities: The present invention pertains to the field of tools for ensuring manufacture of polypeptides and quality control. Specifically, it relates to a method for determining the amount of processed (active) neurotoxin polypeptides in a solution comprising processed neurotoxin polypeptides and partially processed or unprocessed neurotoxin polypeptides. The present invention further... Agent:

20120142025 - Ratiometric immunoassay method and blood testing device: The invention is to devices and methods for rapid determination of analytes in liquid samples. The devices and methods incorporate a sample dilution feature and multiple immunosensors for performing a ratiometric immunoassay on a first analyte and a second analyte, for example, hemoglobin and hemoglobin A1c or albumin and glycosylated... Agent: Abbott Point Of Care Inc.

20120142035 - Calibrator/control for simultaneous assay of proteins capable of complexing with one another: Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and assays for determining the amount of one or more... Agent:

20120142033 - Method for extraction and purification of recombinant proteins from transgenic plants: Extraction and purification of recombinant proteins rendered difficult to extract from transgenic plants by using an extraction solution containing reducing agents and surfactants or an extraction solution containing reducing agents and organic solvents.... Agent: National Institute Of Agrobiological Science

20120142034 - Pvdf membranes: t

20120142036 - Enhanced cleavage of von willebrand factor by adamts13: Novel methods are described for measuring the rate of ADAMTS13-mediated cleavage of von Willebrand Factor (VWF) multimers. Through the use of the reagent, ristocetin, the method can advantageously be performed in the absence of an applied shear stress or added denaturing agent. Also described are methods for diagnosing ADAMTS13-associated disorders... Agent:

20120142037 - Glucose dehydrogenase: A modified pyrroloquinoline quinone glucose dehydrogenase that exhibits a high selectivity for glucose is provided. A modified pyrroloquinoline quinone glucose dehydrogenase is disclosed in which the amino acid residue G at Position 99 of a pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) represented by SEQ ID NO: 1, or the amino acid... Agent: Ultizyme International Ltd.

20120142038 - Kits for assaying enzyme-mediated oxidative demethylation: Methods of assaying enzyme-mediated oxidative demethylation are provided according to embodiments of the present invention which includes combining, under reaction conditions, an oxidative demethylation enzyme, a substrate for the oxidative demethylation enzyme and a formaldehyde detection reagent. Detection of fluorescence is indicative of formaldehyde generated by oxidative demethylation of the... Agent: Arbor Assays LLC

20120142039 - Method for predicting glycaemic response and use thereof: The present invention relates to an in vitro method for predicting the in vivo glycaemic response to carbohydrates in a food. Provided is a method wherein a food is digested in vitro in more than one compartment. Also provided is the use of such a method for determining the suitability... Agent: Nederlandse Organisatie Voor Toegepast-naruurwetenschappelijk Onderzoek Tno

20120142040 - Methods and kits for quantitative methyltransferase and demethylase measurements: The invention provides methods and kits for characterizing the activity of a methyltransferase or demethylase. The method involves enzymatically methylating or demethylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically methylating the peptide substrate with methyl groups that differ in molecular weight... Agent:

20120142041 - Methods and kits for measuring toxicity and oxidative stress in live cells: Compositions and methods for the measuring toxicity, antioxidant capacity, and oxidative stress are provided.... Agent:

20120142043 - Method for automatic determination of sample: A method of determining a kind of a sample, in a method for analyzing a substance by the steps of supplying the sample to be analyzed to a reaction system by a supplying means comprising a transparent region composed of a transparent material, reacting a reagent for detecting the substance... Agent: Mitsubishi Chemical Medience Corporation

20120142044 - Methods for ionophorically screening pore forming bacterial protein toxins and receptors: One embodiment of the present invention is directed to methods for ionophorically screening pore forming bacterial protein toxins and receptors for insect toxicity. The method includes: a) forming a membrane comprising a lipid and an insect receptor, b) contacting the membrane with the pore forming bacterial protein toxin and an... Agent:

20120142042 - Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide: A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus inside cell. The polypeptide conjugated with various functional moieties delivers and... Agent: Yale University

20120142045 - Use of an amorphous silicon layer and analysis methods: A method of detecting substances or reactions of substances in a sample, comprising: (i) providing a layer (CS) based on hydrogenated or unhydrogenated amorphous silicon with attached probes, (ii) bringing the layer (CS) in contact with the sample that may contain the substances that bind specifically to or reacts specifically... Agent: Ecole Polytechnique/dgar

20120142046 - Yeast cells expressing an exogenous cellulosome and methods of using the same: The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can... Agent:

20120142047 - Purification and separation treatment assembly (pasta) for biological products: An assembly capable of capturing and purifying expressed biological products during or at the end of a bioreaction cycle is disclosed wherein a binding resin is kept separated from the contents of the bioreactor allowing capturing, harvesting and purification of biological products in a bioreactor; the invention additionally provides means... Agent: Therapeutic Proteins, Inc.

20120142048 - Nucleic acid which is stabilized against decomposition: The invention relates to a nucleic acid which is stabilised against decomposition by exonucleases. Said nucleic acid contains the following constituents: a) a code sequence coding for a defined protein, b) optimally, a promoter sequence controlling the expression of the code sequence, and c) at least one molecule A added... Agent: Siemens Building Technologies Ag

20120142052 - Method and device for multiple feed cultivation: The current invention is directed to support units for mounting a cell cultivation liquid storage unit which can be connected to a balance, a cell cultivation apparatus using such a support unit, and the use of such a support unit in a method for the cultivation of cells.... Agent:

20120142053 - Method for methanol independent induction from methanol inducible promoters in pichia: A method for producing a polypeptide in a methylotrophic yeast host cell is described, where expression of the polypeptide is controlled by a methanol inducible promoter, including: i) expression of a positive regulator from a non-native promoter, the positive regulator activating transcription from the methanol inducible promoter, and ii) no... Agent: Novozymes A/s

20120142050 - Novel expression vector: m

20120142049 - Recombinant gene expression: Genes are expressed by culturing cells comprising a host chromosome comprising an integrated artificial chromosome comprising recombinant genes, under conditions whereby each recombinant gene is expressed copy number dependently and position independently. Deletions increase expression from recombinant gene(s) inserted into the artificial chromosome.... Agent:

20120142051 - Transcription regulatory factors for mannanases or cellulases, and genes for the transcription regulatory factor: Disclosed are: transcription regulatory factors capable of regulating the transcription or expression of genes for mannanases or cellulases, as mentioned below; and others. Specifically disclosed is a protein selected from the following proteins (a), (b) and (c): (a) a protein comprising the amino acid sequence depicted in SEQ ID NO:2;... Agent: Noda Institute For Science Research

20120142054 - Srsv detection kit: A polynucleotide base sequence represented by SEQ ID NO: 22, a vector containing the polynucleotide and a method of preparing a small round structure virus (SRSV) virus-like particle in insect cells with vector.... Agent: Jp As Rep By Dir-gen Natl Inst Of Inf Dis

20120142055 - Targeted integration into the ppp1r12c locus: Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest.... Agent: Sangamo Biosciences, Inc.

20120142056 - Mammalian expression vector puhab: The present invention relates to the construction and utilization of a new mammalian expression vector that contains a unique multiple cloning site (MCS), designated pUHAB. The pUHAB vector comprises a high copy replication origin (ColE1), a drug resistance gene (TK-Hygromycin), and a human cytomegalovirus promoter operably associated with a unique... Agent:

20120142057 - Method for production of polypeptide: The present invention provides a method capable of producing a natural or recombinant protein in high yield. The present invention relates to a method of producing a polypeptide, comprising culturing a cell which strongly expresses cysteine sulfinic acid decarboxylase and has a transferred DNA encoding a desired polypeptide and thereby... Agent: Chugai Seiyaku Kabushiki Kaisha

20120142058 - Conversion of chitin into n-acetylglucosamine, glucosamine and bioethanol: Compositions and methods are provided for converting chitin into N-acetylglucosamine, glucosamine and ethanol. The chitin may be used directly from the environment, for example, as occurs in invertebrate cuticles, fungal cells and/or algae. Mutant bacteria were created by knocking out or inactivating one or more genes preferably resulting in the... Agent:

20120142060 - Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction: The present invention concerns preparation of DNA molecules, such as a library, using a stem-loop oligonucleotide. In particular embodiments, the invention employs a single reaction mixture and conditions. In particular, at least part of the inverted palindrome is removed during the preparation of the molecules to facilitate amplification of the... Agent: Rubicon Genomics, Inc.

20120142059 - Sequence amplification with target primers: The present disclosure relates to the amplification of target nucleic acid sequences for various sequencing and/or identification techniques. This can be accomplished via the use of target primers and isothermal multiple strand displacement (MDA) processes. The use of these target primers and MDA, as described herein, allows for the reduction... Agent: Life Technologies Corporation

20120142061 - Recombinant colwellia psychrerythraea alkaline phosphatase and uses thereof: A heat labile alkaline phosphatase enzyme and methods of using the same and kits including the same are disclosed. Specifically, a nucleotide sequence of, peptide sequence of, methods of using, and kits comprising, a heat labile alkaline phosphatase isolated from Colwellia psychrerythraea are provided. Methods of over-expression and purification of... Agent: Affymetrix, Inc.

20120142062 - Engineered cleavage half-domains: Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.... Agent: Sangamo Biosciences, Inc.

20120142063 - Nitrilase biocatalysts: The present disclosure relates to polypeptides having nitrilase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.... Agent: Codexis ,inc.

20120142064 - Recombinant bacteria having the ability to metabolize sucrose: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct: a nucleotide sequence from Bacillus licheniformis ATCC® 14580 encoding a polypeptide having sucrose transporter activity and a nucleotide sequence from Bacillus licheniformis ATCC® 14580 encoding a polypeptide having... Agent: E.i. Du Pont De Nemours And Company

20120142065 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent: Xyleco, Inc.

20120142066 - Metabolically enhanced photoautotrophic ethanol producing host cells, method for producing the host cells, constructs for the transformation of the host cells, and method of producing ethanol using the host cells: o

20120142067 - Method for preparing an industrial yeast, industrial yeast, and application to the production of ethanol from at least one pentose:

20120142068 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent:

20120142069 - Interpenetrating biomaterial matrices and uses thereof: The present invention relates to matrices (e.g., fibrin-alginate matrices; fibrin-alginate-matrigel matrices) for culture of cells, organs (e.g., ovary or fragment thereof), cells and cell aggregates (e.g., ovarian follicles, embryoid bodies), and tissues. In some embodiments, protease inhibitors e.g., aprotinin) are used to prevent the degradation of fibrin.... Agent: Northwestern University

20120142070 - Rehydratable matrices for dry storage of taq polymerase in a microfluidic device: Formulations for dry storage of PCR reagents are described. These formulations find use in manufacture of self-contained microfluidic card devices for PCR clinical testing in which the reagents are reconstituted at the point of testing. In these cards, TAQ polymerase is stored “on-board” in vitrified dry form without lyophilization or... Agent: Micronics, Inc.

20120142071 - Thymidine kinase mutants: The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution located toward the N-terminus from a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as... Agent: Darwin Molecular Corporation

20120142072 - Soluble protein and utilization of the same: Disclosed is a method for screening a medicine using a protein, and a compound obtained by the screening method. A compound or a salt thereof inhibiting activity or expression of the protein of the present invention, a neutralizing antibody against the protein, a polynucleotide that are complementary to a polynucleotide... Agent: Ono Pharmaceutical Co., Ltd.

20120142073 - Hide processing methods and compositions: Provided in part herein are compositions that include isolated microbial enzymes, such as proteases, lipases, useful in dehairing leather. Also provided are methods for isolating proteases, lipases, from microbes, as well as methods of reusing these enzymes effectively for several cycles in an environment friendly process.... Agent: West Bengal University Of Technology

20120142074 - Compositions and uses for an alpha-amylase polypeptide of bacillus species 195: Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from Bacillus sp. no. 195, and methods of using the enzyme to clean surfaces and textiles. Also disclosed are variants of the enzyme with different signal sequences.... Agent: Danisco US Inc.

20120142075 - Microbial trypsin mutants having chymotrypsin activity and nucleic acids encoding same: The present invention relates to microbial trypsin variants having chymotrypsin-like activity, comprising: (a) a one or more substitutions corresponding to positions 144, S193, 198, 201, 218, 223, 227, 228, 229, 230, and 231 of amino acids 25 to 248 of SEQ ID NO: 2, (b) one or more deletions corresponding... Agent: Novozymes, Inc.

20120142076 - Bacillus strain for increased protein production: The present invention provides host cells that have been genetically manipulated to have an enhanced capacity to produce proteins of interest. In particular, the invention relates to modified Bacillus sp. Host cells that have at least one inactivated phr gene. The enhanced production of proteins of interest by the modified... Agent: Danisco US Inc.

20120142077 - Synthetic enzymes derived from computational design: Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used... Agent: University Of Washington

20120142078 - System for generation of viable reovirus from cloned cdna: The present invention provides methods for the generation of viable reoviruses using only cloned nucleic acid segments representing the RNA segments of the reovirus genome.... Agent: Vanderbilt University

20120142079 - Minicell based delivery of biologically active compounds: Minicells are used to deliver biologically active compounds including radioisotopes, polypeptides, nucleic acids, small molecules, drug molecules, and chemotherapeutic agents. In some cases, the minicell displays ligands or binding moieties that target the minicell to a desired host cell.... Agent: Vaxiion Therapeutics, Inc.

20120142080 - Live bacterial vaccines for viral infection prophylaxis or treatment: A live bacterium, having a DNA construct stabilized against transduction of other bacteria, having a promoter sequence and encoding a fusion peptide, comprising a bacterial secretion peptide portion and a non-bacterial immunogenic polypeptide portion, having a nucleotide sequence coding for the non-bacterial immunogenic polypeptide portion which has at least one... Agent: Aviex Technologies LLC

20120142081 - Biosynthesis of commodity chemicals: Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting suitable monosaccharides or oligosaccharides, such as those derived from biomass, as well as various aldehydes and/or ketones, into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum... Agent: Bio Architecture Lab, Inc.

20120142082 - Carotenoid production in a recombinant oleaginous yeast: Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing carotenoids (e.g., β-carotene, lycopene, lutein, zeaxanthin, canthaxanthin, astaxanthin) are provided. The strains may also be engineered to co-produce at least one ω-3/ω-6 polyunsaturated fatty acid and/or at least one additional antioxidant. Methods of using the carotenoid products obtained (e.g.,... Agent:

20120142083 - Biofilter: A biofilter for use in treating contaminated gases is provided with a container having a layer of rubber particulate, which serves as a filter media. One preferred source of the rubber particulate is recycled tires. The rubber particulate provides a platform for the growth and maintenance of a microbial ecosystem... Agent:

20120142084 - Graphical interface for analyte meter: Diagnostic systems include a meter that is configured to receive a test sensor during a testing procedure. The diagnostic systems also include a computing device coupled to the meter. The test sensor receives a fluid sample during the testing procedure. The meter includes a measurement system that determines a measurement... Agent: Bayer Healthcare LLC

20120142085 - Systems for rapid identification of pathogens in humans and animals: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or... Agent: Ibis Biosciences, Inc.

20120142086 - Imaging system comprising microlenses and associated device for detecting a sample: The invention relates to an imaging system and an associated device for detecting a sample (4). The imaging system comprises a matrix (24) of photosensors (26), a first lamina (28) disposed opposite the matrix (24) of photosensors defining a face (28A) for supporting the sample, and a set (30) of... Agent: Comissariat A L'energie Atomique Et Aux Energies Alternatives

20120142087 - Reactor for the anaerobic digestion of biomass: A reactor for the anaerobic digestion of biomass, includes: a gas-tight tank that is accessible by a sealed door designed for the intake of the biomass, the tank being designed in the form of a garage; equipment for heating the biomass provided e.g. at the walls of the tank; a... Agent: Enerbiom

20120142088 - Dna-cell conjugates: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.... Agent: The Regents Of The University Of California

20120142089 - Method of separating target cell in biological sample: Provided is a method of separating a target cell in a biological sample. A target cell may be efficiently separated from a biological sample including at least a second cell of similar density to the target cell using the disclosed method of separating a target cell in a biological sample... Agent: Samsung Electronics Co., Ltd.

20120142090 - Protein expression system: The present invention relates to a method of producing a target protein, which method comprises expressing said protein in a host cell which contains a nucleic acid molecule which encodes a chimeric protein, said chimeric protein comprising a signal peptide from a non-mammalian bulk-secreted protein and said target protein; nucleic... Agent:

20120142091 - Antibodies against human angiopoietin 2: The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.... Agent:

20120142092 - Rat embryonic stem cell: The present invention provides a rat embryonic stem cell characterized by having the following properties of (a) expressing Oct3/4 gene and Nanog gene, (b) positive for alkaline phosphatase activity, (c) having an embryoid body forming ability, (d) expressing SSEA (Stage-Specific Embryonic Antigen)-1 and SSEA-4, (e) having the same number of... Agent: Dainippon Sumitomo Pharma Co., Ltd.

20120142093 - Method for inducing differentiation of pluripotent stem cells into neural precursor cells: The present invention provides a method for inducing differentiation of pluripotent stem cells into neural precursor cells, comprising culturing the pluripotent stem cells in the presence of a small molecule BMP inhibitor, and induced neural precursor cells prepared by this method.... Agent: Kyoto University

20120142096 - Fusion proteins of hiv regulatory/accessory proteins: The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins... Agent:

20120142097 - Fusion proteins of hiv regulatory/accessory proteins: The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins... Agent:

20120142094 - Generating ips cells by protein transduction of recombinant potency-determining factors: The present invention relates generally to compositions and methods for reprogramming a primate somatic cell to a higher potency level. Specifically, the invention includes compositions which comprise a recombinant polypeptide that is a potency-determining factor and methods of reprogramming a primate somatic cell to a higher potency level under conditions... Agent: Ld Biopharma, Inc.

20120142095 - Technique for determining the state of a cell aggregation image processing program and image processing device using the technique, and method for producing a cell aggregation: An image processing program (GP) attains (S10) time lapse images, extracts (S20) a cell aggregation from each of the obtained images, and calculates (S50), for the entire region of the cell aggregation, the spatial distribution in pixel values and temporal change in pixel values of a small region in the... Agent: Nikon Corporation

20120142098 - Fc receptor-binding polypeptides with modified effector functions: Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having modified binding characteristics for human Fc gamma receptor IIA (CD32A) leading to increased inhibition of proinflammatory mediators while retaining binding to a target antigen via its Fv portion, which processes comprise altering the polypeptides by substitution of at least... Agent:

20120142100 - Heat shock rna from various species and its use in activation of heat shock transcription factor, in treatment of various diseases in animals and in generation of stress-resistant plants: The present invention provides a novel RNA, designated herein as the “HSR1” (Heat Shock RNA), and its use together with translation elongation factor eEF1A in activation of heat shock transcription factor HSF. The invention further provides the use of HSR1 for generation of novel therapeutics for the treatment of various... Agent: New York University

20120142099 - Novel bak binding protein, dna encoding the protein, and methods of use thereof: The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to... Agent: Genentech, Inc.

20120142101 - Oligonucleotide end caps: Modified nucleic acids are described herein, including pharmaceutical compositions comprising the modified nucleic acids, and methods of using the modified nucleic acids.... Agent: Alnylam Pharmaceuticals, Inc.

20120142102 - Isolation of human umbilical cord blood-derived mesenchymal stem cells: Human umbilical cord blood (UCB) contains mesenchymal stem cells (MSCs) that have higher multipotentiality than adult marrow-derived MSCs. However, it has been difficult to obtain these cells because the frequency of MSCs in UCB is extremely rare (0.4-30 out of 1×108 mononuclear cells). To date, the isolation of MSCs has... Agent: The Board Of Regents Of The University Of Texas System

20120142103 - Method for inducing differentiation into epithelial progenitor cell/stem cell population and corneal epithelial cell population from induced pluripotent stem cells: The present invention relates to: a method for inducing differentiation into an epithelial progenitor cell/stem cell population or a corneal epithelial cell population by culturing, under particular conditions, induced pluripotent stem cells induced from mammalian somatic cells or undifferentiated stem cells; an epithelial progenitor cell/stem cell population or a corneal... Agent:

20120142104 - Supplement for cell cultivation media: A method of preparing a supplement for cell cultivation media, which comprises concentrating porcine blood by centrifugation and obtaining supernatant, adding agonist for activating platelets into the supernatant to obtain activated supernatant, and sterilizing the activated supernatant is presented. A supplement for cell cultivation media, which is made by the... Agent:

20120142105 - Production and extraction of procyanidins from plant cell cultures: A method of preparing cocoa oligomeric procyanidins from cocoa cell cultures grown in the presence of monosaccharide can increase production of procyanidins as follows: culturing cells sufficient to result in production of cocoa oligomeric procyanidins at a first rate; and introducing a monosaccharide to the cells sufficient for inducing the... Agent: Dianaplantsciences, Inc.

20120142106 - Method of forming dendritic cells from embryonic stem cells: This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells.... Agent: Wisconsin Alumni Research Foundation

20120142108 - Compositions for treating bacterial infections: Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of... Agent: St. Jude Children's Research Hospital

20120142107 - Method and system for somatic cell nuclear transfer: Provided is a method for nuclear transfer. An exogenous donor nucleus is introduced into an enucleated oocyte and one or more enucleated sperm cells or one or more enucleate sperm cell fractions are introduced into the oocyte. The one or more sperm cells or one or more sperm cell fractions... Agent: Mazorel Ltd.

20120142109 - Method for producing t cell population under presence of retinoic acid: Disclosed is a method for producing a cell population containing memory-like T cells, said method being characterized by including a step for in vitro culturing of a cell population containing T cells or T cell precursor cells using a retinoic acid and a CD3 ligand. Further disclosed is a method... Agent:

20120142110 - Method of genetically altering and producing allergy free cats: A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, Fel d I. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct. The phenotype of the transgenic cat is transmissible to its... Agent:

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