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Chemistry: molecular biology and microbiology May archived by USPTO category 05/12

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
05/31/2012 > 137 patent applications in 63 patent subcategories. archived by USPTO category

20120135390 - Plasma treatment for growth factor release from cells and tissues: Aspects of the present invention are related to methods comprising contacting an endothelial cell in an endothelial cell population with a non-thermal plasma to release an angiogenic growth factor. The released angiogenic growth factor may induce endothelial cell proliferation. In certain embodiments, the angiogenic growth factor is fibroblast growth factor-2.... Agent: Drexel University

20120135391 - Method of blood pooling and storage: The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from a plurality of blood units, and inactivating any pathogen contained therein. A storage solution added to the cellular component results in a cell-containing product that is... Agent: New York Blood Center, Inc.

20120135392 - Ultrasound stimulation devices and techniques: Ultrasound stimulation devices and related techniques are disclosed. An ultrasound transducer for generating ultrasound energy is carried by a transducer housing that seals the transducer and may also include a positioning element for positioning the transducer proximate an application area to which generated ultrasound energy is to be applied. The... Agent: The Governors Of The University Of Alberta

20120135394 - Apparatus for integrated real-time nucleic acid analysis, and method for detecting a target nucleic acid using same: Provided are an apparatus for integrated real-time nucleic acid analysis and a method for detecting target a nucleic acid using the same, and more particularly an integrated real-time nucleic acid analysis for simultaneously performing qualitative analysis or quantitative analysis on genes from various kinds of plural biological samples and a... Agent: Bioneer Corporation

20120135397 - Human immunodeficiency virus type 1 (hiv-1) detection method and kit therefor: The invention provides oligonucleotide(s) derived from the gene sequence encoding the gag region of HIV-I for simple, specific and/or sensitive test(s) for the presence of HIV-I. In particular, the present invention provides oligonucleotide(s) for test(s) for HIV-I. Kit(s) comprising the oligonucleotide(s) for use as probe(s) and/or primer(s) useful in the... Agent: Agency For Science, Technology And Research

20120135398 - Method of detection and related detection device: A method that uses an (DOPC) surfactant based biofilm that reacts with a material in a known manner, and a device that utilizes such a biofilm, to detect a material of interest is provided. The principles of the present invention are particularly useful in detecting/measuring a material that is harmful... Agent:

20120135395 - Methods and compositions for determining altered susceptibility of hiv-1 to anti-hiv drugs: This invention relates, in part, to methods and compositions for determining altered susceptibility of a human immunodeficiency virus (“HIV”) to the non-nucleoside reverse transcriptase inhibitors (“NNRTIs”) efavirenz (“EFV”), nevirapine (“NVP”), and delavirdine (“DLV”), the nucleoside reverse transcriptase inhibitor AZT, and the integrase strand transfer inhibitors diketo acid 1, diketo acid... Agent: Monogram Biosciences, Inc.

20120135396 - Multi-shell microspheres with integrated chromatographic and detection layers for use in array sensors: The development of miniaturized chromatographic systems localized within individual polymer microspheres and their incorporation into a bead-based cross-reactive sensor array platform is described herein. The integrated chromatographic and detection concept is based on the creation of distinct functional layers within the microspheres. In this first example of the new methodology,... Agent: Board Of Regents, The University Of Texas System

20120135393 - Real-time pcr point mutation assays for detecting hiv-1 resistance to antiviral drugs: Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID... Agent: The Gov't Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services

20120135399 - Cancer biomarker and methods of using thereof: Described herein are biomarkers which can be used for identifying a subject at risk for or evaluating the progression of cancer. In certain aspects, these biomarkers can be used to identify cancer stem cells. These biomarkers can include, but are not limited to, Oc1 or molecular variants thereof, Oc1 target... Agent: University Of Utah Research Foundation

20120135400 - Novel fluorescent and colored proteins, and polynucleotides that encode these proteins: The subject invention provides new fluorescent and/or colored proteins, and polynucleotide sequences that encode these proteins. The subject invention further provides materials and methods useful for expressing these detectable proteins in biological systems.... Agent:

20120135407 - Compositions and methods for intramolecular nucleic acid rearrangement: Aspects of the present invention are drawn to processes for moving a region of interest in a polynucleotide from a first position to a second position with regard to a domain within the polynucleotide, also referred to as a “reflex method”. In certain embodiments, the reflex method results in moving... Agent:

20120135403 - Fibrosis susceptibility gene and uses thereof: The present invention discloses the identification of a fibrosis susceptibility gene locus, the CTGF gene locus, which can be used for detecting predisposition to, diagnosis and prognosis of fibrosis as well as for the screening of therapeutically active drugs. The invention resides, in particular, in a method which comprises detecting... Agent:

20120135402 - Gene sequence variances in genes related to folate metabolism having utility in determining the treatment of disease: The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods of treatment of a disease or condition. The variance information is indicative of the expected response of a patient to a method... Agent:

20120135405 - Instrument and method for optical particle sensing: A new device capable of measuring the number of particles present in a colloidal suspension is disclosed, which includes a forward scatter detector, an extinction detector, a laser beam, a cylindrical lens with which to create a plane of light through which particles can pass, and the various pumps and... Agent: Invitrox, Inc

20120135406 - Method for determining lymph node metastasis in cancer or risk thereof and rapid determination kit for the same: The objective of the present invention is to provide a method and a means of rapidly and reliably detecting lymph node metastasis in cancer or the risk of lymph node metastasis. Specifically, the present invention provides a method and a rapid determination kit for detecting lymph node metastasis in cancer... Agent:

20120135401 - Methods and compounds for the diagnosis of inflammatory disease and identification of pharmacological agents useful in the treatment of inflammatory disease: Methods for the diagnosis of inflammatory bowel diseases and the identification of agents useful in the treatment of such diseases based upon the agent's effect on reducing Pim-2 expression.... Agent: Boehringer Ingelheim Pharmaceuticals, Inc.

20120135404 - Optoelectronic detection system: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor... Agent: Massachusetts Institute Of Technology

20120135418 - Automatic detection kit for detecting hla alleles using real-time polymerase chain reaction: Provided is an automatic detection kit for automatically detecting HLA alleles using a real-time polymerase chain reaction (PCR). The real-time PCR is performed on DNA isolated from a sample using a primer which is able to specifically bind to HLA alleles and a fluorescent probe which is able to detect... Agent: Catholic University Industry Academic Cooperation Foundation

20120135414 - Chemically-enhanced primer compositions, methods and kits: A composition is provided comprising a negatively charged group, an oligonucleotide sequence and at least none or one nuclease-resistant linkage group to form a chemically-enhanced primer. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the primer as well as a method of preparing DNA... Agent: Life Technologies Corporation

20120135416 - Compositions and methods for treating and diagnosing pancreatic cancer: The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors.... Agent: The Regents Of The University Of Michigan

20120135413 - Compositions for use in security marking: A composition comprising: a plurality of identical first synthetic nucleotide oligomers; and a plurality of identical second synthetic nucleotide oligomers which are different to the first synthetic nucleotide oligomers, wherein each of the first synthetic nucleotide oligomers comprises a first primer binding sequence of bases, a first identifier sequence of... Agent: Selectamark Security Systems PLC

20120135415 - Detecting cancer with anti-cxcl13 and anti-cxcr5 antibodies: Methods for diagnosing cancer in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a... Agent: Morehouse School Of Medicine

20120135410 - Method for imaging on thin solid-state interface between two fluids: Described herein is a fluid cell for an optical microscopy tool having a solid state membrane having a first side and a second, opposing side; a first fluid chamber comprising a first fluid having a first refractive index located on the first side of the membrane; and, a second fluid... Agent:

20120135419 - Method of determination of diagnosis and prognosis in patients with b-cell chronic lymphocytic leukemia and oligonucleotides for use in this method: The invention provides a method of determination of diagnosis and prognosis of B-cell chronic lymphocytic leukemia from a biological sample collected from the body of a patient, wherein the status of Wnt/PCP signaling pathway is determined. Within the framework of the present invention the relation of CLL and molecular signaling... Agent: Masarykova Univerzita

20120135417 - Methods for screening and identifying compounds: Methods, compositions and assays that measure the effect of a test compound on induction of ligand-induced ribowitch-mediated transcription termination are disclosed. The methods and the assays are useful in identifying drug candidates that modulate transcription by binding to a riboswitch, for example.... Agent:

20120135409 - Methods of monitoring conditions by sequence analysis: There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer. Provided herein are methods for using DNA sequencing to identify personalized biomarkers in patients with autoimmune disease and other conditions. Identified biomarkers can be used to determine the... Agent: Sequenta, Inc.

20120135411 - Pyrococcus furiosus strains and methods of using same: Provided herein are methods for transforming a Pyrococcus furiosus with a polynucleotide. In one embodiment, the method includes contacting a P. furiosus with a polynucleotide under conditions suitable for uptake of the polynucleotide by the P. furiosus, and identifying transformants at a frequency of, for instance, at least 103 transformants... Agent:

20120135412 - Quality control bioassays for nutriceutical and medicinal products: Bioassays for detecting the ability of one sample of a food substance, nutritional supplement, therapeutic agent and/or disease preventive agent relative to that of a second sample of such a substance, supplement and/or agent to inhibit, upregulate or otherwise modulate translation initiation, and thereby demonstrate a disease curative and/or preventive... Agent: President And Fellows Of Harvard College

20120135408 - Unc-45a splice variants based cancer diagnostics and therapeutics: Methods and compositions to diagnose and treat cancers using UNC-45A splice variants are disclosed. Expression of a human UNC-45A929 splice variant that is shorter than UNC-45A944 splice variant is increased in cancer cells including metastatic cancers. siRNA to inhibit or downregulate UNC-45A splice variants in cancers are disclosed.... Agent: The Board Of Regents Of The University Of Texas System

20120135420 - Method for detecting the presence of target bacteria or a target component carbohydrate antigen thereof: A process is disclosed for separating a carbohydrate antigen from a Gram-positive or Gram-negative bacteria in a purified form that contains no more than 10% protein. The separated antigen is coupled to an affinity column, over which polyclonal antibodies to the same bacteria are chromatographed and recovered in a purified... Agent: Binax, Inc

20120135423 - Methods for gpcr signaling pathway determination using biosensor-cell assays: A system and method for GPCR signaling pathway analysis and elucidation using a biosensor, a live-cell, and a pathway active compound, as defined herein.... Agent:

20120135424 - Mer diagnostic and therapeutic agents: Mer diagnostic and therapeutic agents are disclosed. The agents are useful in the diagnosis and treatment of a variety of diseases including leukemia, lymphoma, and clotting disorders.... Agent: The Regents Of The University Of Colorado, A Body Corporate

20120135421 - Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins: The present invention relates to immobilization compounds of formula (I), immobilization products and preparations thereof as well as methods and uses for the identification of phosphatidylinositol kinase interacting compounds or for the purification or identification of phosphatidylinositol kinase proteins.... Agent: Cellzome Ag

20120135422 - Anti-gpcr antibody and the method of producing the same: Disclosed is a discussion of a method for producing anti-mammalian GPCR antibody and of the antibody itself. Anti-mammalian GPCR antibody is produced through immunization involving exposure of fish to full-length or truncated mammalian GPCR, and anti-mammalian GPCR antibody that can be obtained by this method is also discussed.... Agent: Mie University

20120135430 - Complement assays and uses thereof: The present invention provides methods for assessing complement activation and methods for assessing the ability of an agent or condition of interest to modulate complement activation. The present invention provides methods for assessing whether a subject has or is at increased risk of developing a complement-mediated disorder, e.g., age-related macular... Agent: Potentia Pharmaceuticals, Inc.

20120135432 - Diagnostic method for determining the susceptibility to delivery and reagent kit for use thereof: The invention relates to a diagnostic method for detecting susceptibility to delivery, and to a test kit for this purpose. A low, but higher than baseline level concentration of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1), which is due to leakage from decidual cells, is detected by an immunological assay... Agent: Oy Medix Biochemica Ab

20120135425 - Elisa for haptoglobin-matrix metalloproteinase 9 complex as a diagnostic test for conditions including acute inflammation: A method for detecting a haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) complex in a biological sample. The sample includes incubating the biological sample with a capture reagent immobilized on a solid support to bind Hp-MMP 9 to the capture reagent. The capture reagent includes a monoclonal antibody that binds MMP9. The... Agent: The Ohio State University Research Foundation

20120135426 - Method for quantifying phosphokinase activity on proteins: The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine... Agent: Life Technologies Corporation

20120135427 - Methods for determining maternal health risks: The present description relates to a method for determining the risk of a pregnant woman developing a hypertensive disorder, more specifically gestational hyper-tension or late onset preeclampsia. The present description provides methods useful for determining risk that a pregnant individual will develop a hypertensive disorder or condition of pregnancy, such... Agent: Wallac Oy

20120135428 - Novel markers for chronic kidney disease: The present invention relates to a method for determining the progression of chronic kidney disease in a subject suspected of having chronic kidney disease, comprising of determining the expression levels of at least one marker selected from (a) FGF23; and (b) adiponectin in a biological sample. Furthermore, the present invention... Agent:

20120135429 - Pro-grp as a surrogate marker to predict and monitor response to bcl-2 inhibitor therapy: A method for classifying cancer patients as eligible to receive cancer therapy with a Bcl-2 inhibitor comprising determination of the presence or absence in a patient tissue sample of levels of pro-GRP, as a surrogate marker for the presence of chromosomal copy number gain at chromosomal locus 18q21-q22. The classification... Agent:

20120135433 - Prognosis diagnosis method and prognosis diagnosis kit for sepsis or multiple organ failure: Disclosed are: a prognosis diagnosis method which can diagnose the prognosis of a patient suffering from sepsis or sepsis-related multiple organ failure in a simple manner and with high accuracy and a prognosis diagnosis kit for use in the prognosis diagnosis method. The prognosis diagnosis method comprises: a first detection... Agent: The University Of Tokyo

20120135431 - Type iv collagen-like immunoreactive peptide: A type IV collagen-like immunoreactive peptide immunologically reacts with an isolated, chronic nephritis-derived biological sample. Preferably, the type IV collagen-like immunoreactive peptide includes at least one member selected from the group consisting of at least one chain selected from alpha 1 to alpha 6 chains as a constituent alpha chain,... Agent:

20120135434 - Mcpp immunoassay: The invention describes a practical and robust multi-antibody approach to the sensitive immunodetection and determination of the drug of abuse m-chlorophenyl piperazine (mCPP). The invention also describes methods and kits for mCPP detection in an in vitro sample.... Agent: Randox Laboratories Ltd.

20120135435 - Methods for identifying factors that control the folding of amyloid proteins of diverse origin: The present invention provides a yeast cell based system for determining factors that control the folding of amyloid proteins of diverse origins. Further the present invention provides methods of using such a system to screen for reagents that affect amyloid formation, a process that is integral to several devastating human... Agent: Arch Development Corporation

20120135436 - Method of determining enzymatic activity in biological media: A reliable, fast and convenient method is provided to determine the change in concentration of enzyme in time in a biological medium in the presence of a signal substrate that corrects for substrate consumption, color-dependency of the signal and non-linearity between the concentration of the leaving group of the signal... Agent:

20120135437 - Biosensors utilizing ink jet-printed biomolecule compatible sol gel inks and uses thereof: Novel solid-phase biosensors that utilize ink jet printing of biocompatible sol-gel based inks to create sensor strips are reported herein. Biomolecules and other reagents useful in bioassays to detect, for example, pathogenic microorganisms or toxic substances, are immobilized on a substrate, which can be paper based, by layering these substances... Agent: Mcmaster University

20120135438 - Detecting a microorganism strain in a liquid sample: The invention concerns a medium for detecting, identifying and differentiating a microorganism strain in a liquid medium by contacting said liquid sample with a combination of chromogens substrates of enzymes expressed or not by the strain to be detected, the final coloration of the mixture being detectable in the wavelengths... Agent:

20120135439 - Method for production of accumulated product of nano-substance, accumulated product of nano-substance, device comprising the accumulated product, and method for analysis of structure of nano-substance: A method for producing an accumulated product of a nano-substance that enables the accumulated product of the nano-substance to be produced at low cost, by a simple process that requires few conditions to be controlled and requires minimal energy, and with good reproducibility. Specifically, a method for producing an accumulated... Agent: Genesis Research Institute, Incorporated

20120135440 - Cationic anti-microbial peptides and methods of use thereof: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a cationic anti-microbial peptide that is degradable by an enzyme produced and/or secreted by a microorganism, and detecting degradation or... Agent: Systagenix Wound Management (us), Inc.

20120135441 - Enzymes and methods for resolving amino vinyl cyclopropane carboxylic acid derivatives: Preparation and isolation of amino vinyl cyclopropane carboxylic acid derivatives and salts thereof, methods of resolving enantiomers, and methods of identifying compositions and/or enzymes that are capable of resolving racemic or partially enantiomerically enriched mixtures.... Agent: Dr. Reddy's Laboratories Ltd.

20120135442 - Protein crystallization using molecularly imprinted polymers: The invention relates to a method comprising: providing a molecularly imprinted polymer imprinted with a first peptide or protein; exposing said molecularly imprinted polymer to a supersaturated solution of a second peptide or protein; and forming a nucleus of and/or growing a crystal of said second peptide or protein on... Agent: University Of Surrey

20120135443 - Rapid bed-side measurement of neutrophil elastase activity in biological fluids: The subject invention provides novel devices and methods for the detection and quantification of neutrophil elastase activity in biological samples.... Agent:

20120135444 - Sampling devices and methods of use: The present disclosure provides devices and rapid methods to acquire a wound sample to detect the presence of NOx and, optionally, one or more other analytes that are indicative of the status of a wound.... Agent:

20120135445 - Cell transport system: The present invention relates to a system for cell transport Said system allows the transport of cells, assuring their integrity and viability during the entire transport process. It consists of a system suitable for a wide variety of formats which allows a broad range of technical applications of the system... Agent: Histocell, S.l.

20120135449 - Iterative staining of biological samples: Automated methods and devices that facilitate iterative staining of biological samples from imaging applications are provided. The methods include the steps of providing a small volume flow cell containing a biological sample, applying a stain to the biological sample, combining at least two precursor reagents to form an activated destaining... Agent: General Electric Company

20120135451 - Method and apparatus for evaluation of toxicity: The present invention pertains to a method for evaluation of the toxicity of compounds comprising the use of spermatozoa. The inventions also relates to a high throughput system for the toxicity evaluation.... Agent: Biophos Sa

20120135448 - Methods and devices for the fabrication of 3d polymeric fibers: The present invention provides methods and devices for the fabrication of 3D polymeric fibers having micron, sub-micron, and nanometer dimensions, as well as methods of use of these polymeric fibers.... Agent: President And Fellows Of Harvard College

20120135446 - Microfluidic device and related methods: A combinatorial microenvironment generator is configured for the generation of arbitrary, user-defined, steady-state, concentration gradients with negligible to no flow through the growth medium to perturb diffusion gradients or cellular growth. More importantly, the absolute concentrations and/or gradients can be dynamically altered upon request both spatially and temporally to impose... Agent: University Of Maine System Board Of Trustees

20120135452 - Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof: A microfluidic device for culturing cells, termed a microscale cell culture analog (μCCA), is provided. The microfluidic device allows multiple cell or tissue types to be cultured in a physiologically relevant environment, facilitates high-throughput operation and can be used for drug discovery. The microfluidic device uses gravity-induced fluidic flow, eliminating... Agent: Cornell University

20120135447 - Nucleic acids encoding t2r, a novel family of taste receptors: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.... Agent: The Regents Of The University Of California

20120135450 - Substrates, devices, and methods for quantitative liquid crystal assays: The present invention relates to the field of molecular diagnostics, and in particular to diagnostics based on a liquid crystal assay format. In particular, the present invention provided improved substrates and methods of using liquid crystal assays for quantitating the amount of an analyte in a sample. The present invention... Agent: Platypus Technologies, LLC

20120135453 - Methods of treatment using cca1 inhibitors: Provided herein are methods for the treatment or prevention of a fungal infection in a host comprising the administration to the host a therapeutically or prophylactically effective amount of a CCA1 inhibitor.... Agent: Ucb Pharma Sa

20120135457 - Apparatus and method for the detection and analysis of particles in fluids: The invention relates to apparatus for the detection of particles and for particle analysis. The apparatus comprises a sample holder comprising a base and a projection extending from the base. The base includes a contact region where, in use, the surface of a fluid sample may contact the projection. The... Agent:

20120135456 - Method and kit for detection of guaiacol-producing bacterium: Disclosed is a method for detecting guaiacol-producing bacteria in a specimen comprising culturing the specimen or a dilution thereof on a plate of a solid medium for acidophilic bacteria comprising a compound represented by the following formula, wherein R is —H, —OH, —C(O)H, —C(O)CH3, —COOH, C1-C3 alkyl or C1-C3 alkenyl,... Agent: Calpis Co., Ltd.

20120135454 - Methods for separation, characterization and/or identification of microorganisms using spectroscopy: The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be... Agent: Biomerieux Inc.

20120135455 - Smart packaging for detecting microorganisms: The present invention relates to novel smart packaging, designed using a novel material comprising a partially polar adsorbent solid base impregnated with a solution of vanillin, which allows the growth of microorganisms in different types of products to be detected visually without having to be in direct contact with the... Agent: Universidad De Zaragoza

20120135458 - Closed loop monitoring of automated molecular pathology system: A closed loop automated method for staining of a biological sample is provided. The method comprises providing a biological sample, staining at least a portion of the biological sample by flowing in a reagent, monitoring one or more optical characteristics of the biological sample, and calculating a figure of merit... Agent: General Electric Company

20120135459 - Novel fluorinated rhodamines as photostable fluorescent dyes for labelling and imaging techniques: The present invention relates to novel fluorinated 3,6-diaminoxanthene compounds derived from the basic structural formula (I) and to their uses as photostable fluorescent dyes, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional microscopy, stimulated emission depletion (STED) reversible saturable optically linear fluorescent transitions (RESOLFT) microscopy, and... Agent: Max-planck-gesellschaft Zur Foerderung Der Wissenschaften E.v.

20120135462 - Polymer-von willebrand factor-conjugates: The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein.... Agent: Baxter International Inc.

20120135461 - Production of glycoproteins with reduced o-glycosylation comprising the use of an alpha-1,2-mannosidase: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of one or more α-1,2-mannosidases from Coccidiodes immitis, Coccidiodes posadasii, Penicillium citrinum, Magnaporthe grisea, Aspergillus saitoi, Aspergillus oryzae, and Chaetomiun globosum or a catalytically... Agent:

20120135460 - Recombinant porcine chymotrypsin: The present invention generally relates to the field of proteinases and more specifically to chymotrypsin. In particular, the present invention relates to recombinant porcine chymotrypsin and its use in food applications.... Agent: Nestec S.a.

20120135463 - Rhamnose promoter expression system: b) a prokaryotic signal sequence operably linked to the nucleic acid sequence. The prokaryotic signal sequence is selected from signal peptides of periplasmatic binding proteins for sugars, amino acids, vitamins and ions. The expression of the nucleic acid sequence is controlled by the promoter region. The vector is used for... Agent:

20120135464 - Stirrer system: The present invention concerns a stirrer system for animal cell culture consisting of a combination of at least one radially-conveying stirrer element and at least one axially-conveying stirrer element, wherein at least three stirrer elements must be present and the uppermost stirrer element is an axially-conveying stirrer element. The stirrer... Agent:

20120135468 - Beta-galactosidase derived from bacillus circulans: Disclosed is a novel β-galactosidase. Specifically disclosed are a β-galactosidase derived from Bacillus circulans and a gene for the β-galactosidase. The β-galactosidase can be used, for example, in the production of milk, dairy products, fermented dairy products, galacto-oligosaccharides or supplements for foods.... Agent: Amano Enzyme Inc.

20120135465 - Endoglucanase for reducing the viscosity of a plant materials slurry: The present disclosure relates to composition comprising EG cellulase and methods of use, thereof. The compositions are useful, e.g., for reducing the viscosity of plant material slurry.... Agent:

20120135467 - Hmo synthesis: The present invention relates to a cell to be stably cultured in a medium, which cell is adjusted for the production of oligosaccharides, the cell being transformed to comprise at least one nucleic acid sequence coding for an enzyme involved in oligosaccharide synthesis. In addition the cell is transformed to... Agent: Jennewein Biotechnologie Gmbh

20120135466 - Production of maltotetraose syrup using a pseudomonas saccharophila maltotetraohydrolase variant and a debranching enzyme: The combination of a Pseudomonas saccharophila G4-forming amylase (PS4) variant and a pullulanase advantageously can catalyze at a high temperature saccharification to produce an increased amount of maltotetraose, which can be used downstream in a process of producing a maltotetraose syrup. In one embodiment, a thermostable PS4 variant supplement with... Agent: Danisco US Inc.

20120135469 - Novel glycosyltransferase, novel glycosyltransferase gene, and novel sugar donor compound: wherein R1 is independently selected from hydrogen, or C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl in which each of the groups is unsubstituted or substituted with one or more groups selected from OH, F, Cl, Br, I, CN, NO2, and SO2, n is 0, 1, 2, 3, 4 or 5,... Agent: National University Corporation Tokyo University Of Agriculture And Technology

20120135470 - Biotechnological production of chondroitin: An innovative method is described for the production of chondroitin at high concentration, by fermentation of genetically mutated bacteria.... Agent: Altergon S.a.

20120135472 - Hot-start pcr based on the protein trans-splicing of nanoarchaeum equitans dna polymerase: Disclosed is a hot-start PCR method, based on protein trans-splicing of intein-inserted large (Neq L) and small (Neq S) fragments of Neq DNA polymerase. The method comprises: preparing a PCR reaction mixture containing a sample DNA and primers; adding the Neq L fragment and the Neq S fragment together to... Agent: Research & Business Foundation Sungkyunkwan University

20120135471 - Method for concentrating sample constituents and amplifying nucleic acids: A method is disclosed for concentrating sample constituents and for multiplying nucleic acids from a biological sample which are containing in the sample constituents. The nucleic acids are amplified on the same filter on which the sample constituents are also separated off.... Agent: Robert Bosch Gmbh

20120135473 - Processes using dual specificity oligonucleotide and dual specificity oligonucleotide: The present invention relates to various processes by a template-dependent extension reaction using a dual specificity oligonucleotide and a dual specificity oligonucleotide composed of three different Tm portions therefor. Demonstrated in the present invention are the features of the dual specificity oligonucleotide, which are high hybridization specificity and mismatch tolerance.... Agent: Seegene, Inc.

20120135474 - Hemicellulose-degrading enzymes: The present disclosure provides methods for the conversion of hemicellulose into fermentable sugars using enzymes isolated from Prevotella bryantii. Hemicellulose-degrading enzymes include an endoxylanase, a β-xylosidase, a bifunctional β-xylosidase and β-glucosidase, a bifunctional arabinofuranosidase and β-xylosidase, a glucuronidase, and an acetyl xylan esterase. The enzymes can be used to release... Agent: The Board Of Trustees Of The University Of Illinois

20120135475 - Liquefied biomass: The invention is directed to a liquefied sugar beet and/or sugar cane biomass material as well as production methods and uses thereof. The liquefied biomass is storage stable and can be used for the production of a product resulting from fermentation.... Agent: Sud-chemie Ag

20120135476 - Process for preparing n-heterocyclic optically active alcohols: by reduction of the corresponding ketone, where the reduction is carried out using a dehydrogenase having the polypeptide sequence SEQ ID NO:2 or NO:4, or using a polypeptide sequence where, compared to SEQ ID NO:2 or NO:4, up to 25% of the amino acid residues are modified by deletion; insertion,... Agent: Basf Se

20120135477 - Biocatalytic production of ambroxan: The invention relates to a process for the biocatalytic production of ambroxan by means of a polypeptide with the activity of a homofarnesol-ambroxan cyclase, which are a novel class of enzymes.... Agent: Basf Se

20120135478 - Algal medium chain length fatty acids and hydrocarbons: The present invention provides methods and compositions for production of algal-based medium chain fatty acids and hydrocarbons. More specifically, the invention relates to a Nannochloropsis algal strain and mutants that produces high amounts of C16 fatty acids and hydrocarbons. The present invention provides methods and compositions for production of algal-based... Agent: Arizona Board Of Regents For And On Behalf Of Arizona State University

20120135479 - Fractionation of oil-bearing microbial biomass: The invention generally relates to the production of hydrocarbon compositions, such as a lipid, in microorganisms. In particular, the invention provides methods for extracting, recovering, isolating and obtaining a lipid from a microorganism and compositions comprising the lipid. The invention also discloses methods for producing hydrocarbon compositions for use as... Agent: Solazyme, Inc.

20120135480 - Methods for producing polyhydroxyalkanoates from biodiesel-glycerol: Methods are provided for producing biodegradable polyhydroxyalkanoates (PHAs) with desired geometry, molecular mass, mechanical and/or physical-chemical properties from glycerol, an inexpensive carbon source and byproduct of the biodiesel industry. Microorganisms capable of converting carbon to PHA can be used to convert biodiesel-glycerol to poly-3-hydroxybutyrate (PHB) or other monomer or copolymer... Agent:

20120135481 - Compositions and methods for 3-hydroxypropionic acid production: The present application discloses genetically modified yeast cells comprising an active 3-HP fermentation pathway, and the use of these cells to produce 3-HP.... Agent: Novozymes, Inc.

20120135482 - Dicarboxylic acid fermentation process: The present invention relates to a process for producing a dicarboxylic acid, comprising fermenting a recombinant fungal cell in a suitable fermentation medium, in the presence of high carbon dioxide concentrations.... Agent: DsmIPAssets B.v.

20120135484 - Method for producing microbial fermentation product: e

20120135483 - Preparation of isomerically pure substituted cyclohexanols: The present invention relates to the preparation of isomerically pure substituted cyclohexanols starting from a mixture of cis/trans substituted cyclohexanols which comprises reacting the cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase, to give the trans semi-ester which is separated off... Agent: Basf Se

20120135486 - Methods and compositions for the extracellular transport of biosynthetic hydrocarbons and other molecules: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into hydrocarbons, e.g., n-alkanes and n-alkenes, wherein the n-alkanes are secreted into the culture medium via recombinantly expressed transporter proteins. In particular, the use of such organisms... Agent: C/o Joule Unlimited Technologies, Inc.

20120135485 - Sorbent and process for removing fermentation inhibitors: The invention pertains to, for example, an improved sorbent and process for removing fermentation inhibitors such as furfural and/or HMF in microbial processes utilizing fermentable sugars obtained from biomass including, for example, in the production of bioalcohols. The sorbent is capable of separating one or more inhibitors from monosaccharides and... Agent: Georgia Tech Research Corporation

20120135487 - Mutant glycerol dehydrogenase (glydh) for the production of a biochemical by fermentation: e

20120135489 - Method of alcohol production: The present invention relates to a process for producing alcohol from a cellulosic material, said process comprising: hydrolyzing said cellulosic material with an aqueous acid to produce a hydrolysate; extracting acid and water from said hydrolysate with a water-miscible organic extraction solvent to yield (a) a first aqueous acidic solution... Agent: Weyland As

20120135488 - Methods for the preparation and use of cellulosic feedstock for ethanol production: The instant invention provides methods for increasing the efficiency and yield of cellulosic ethanol production.... Agent: Bp Corporation North America, Inc.

20120135490 - Isoprene hydrocarbon production using genetically engineered cyanobacteria: The present invention provides methods and compositions for producing isoprene hydrocarbons from cyanobacteria.... Agent: The Regents Of The University Of California

20120135491 - Method for producing biogas or sewage gas: The invention relates to a method for producing biogas or sewage gas by a multi-stage anaerobic reaction of biomass and/or sludge. Considering the disadvantages of the known prior art, a method is to be provided that leads to a higher yield of raw gas or biogas and a higher content... Agent: Dge Dr.-ing Guenther Engineering Gmbh

20120135492 - Apparatus and method of using an agricultural waste digester and biogas generation system: An agricultural waste digester and biogas generation system. The system includes a digester assembly having a cylindrical body, a hollow interior, a center axis and a plurality of wheel segments within the interior of the digester assembly. A gas conduit extends from the interior of the digester assembly to a... Agent:

20120135493 - Methods for phototransfecting nucleic acids into live cells: The present invention includes methods for transferring a multigenic phenotype to a cell by transfecting, preferably by phototransfection, and locally transfecting a cell or a cellular process with a laser while the cell is bathed in a fluid medium comprising two or more nucleic acids, thereby introducing the nucleic acid... Agent: The Trustees Of The University Of Pennsylvania

20120135494 - Systems and methods for magnetic separation of biological materials: A magnetic separator comprising a separation chamber is provided. The magnetic separator comprises an inlet and at least one outlet, and a magnetic source operatively coupled to the separation chamber and comprising a plurality of magnets that can be selectively turned off and on to create a dynamic magnetic field... Agent: General Electric Company

20120135495 - Neurotoxins with enhanced target specificity: Modified neurotoxins that contain protease cleavage sites susceptible uniquely to proteases present in certain tissues are described. The toxins can be selectively activated by proteases in muscle or selectively inactivated by proteases in blood.... Agent: Allergan, Inc.

20120135496 - Protein belonging to the tnf superfamily involved in signal transduction, nucleic acids encoding same and methods of use thereof: A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting... Agent: The Rockefeller University

20120135497 - Differentially fluorescent yeast biosensors for the detection and biodegradation of chemical agents: The present disclosure provides methods, devices, systems and compositions for detecting and/or modifying chemical agents. In some embodiments, a biosensor may be configured to detect a chemical agent, modify that agent to a form with reduced toxicity, and/or detect the modified form of the chemical agent. The present disclosure also... Agent:

20120135498 - Method for producing nucleases of a gram negative bacterium while using a gram positive expression host: A method for producing a nuclease of a gram negative bacterium or a nuclease preparation containing a nuclease of a gram negative bacterium including expression of the nuclease in a gram positive bacterium and subsequent secretion of the nuclease, as well as a nuclease or a nuclease preparation that can... Agent: C-lecta Gmbh

20120135500 - Cellulase variants with improved expression, activity and stability, and use thereof: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.... Agent: Danisco US Inc.

20120135499 - Exo-endo cellulase fusion protein: The present invention relates to a heterologous exo-endo cellulase fusion construct, which encodes a fusion protein having cellulolytic activity comprising a catalytic domain derived from a fungal exo-cellobiohydrolase and a catalytic domain derived from an endoglucanase. The invention also relates to vectors and fungal host cells comprising the heterologous exo-endo... Agent: Danisco US Inc.

20120135501 - Recombinant poxvirus expressing homologous genes inserted: The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use... Agent: Bavarian Nordic A/s

20120135503 - Minicell based delivery of biologically active compounds: Minicells are used to deliver biologically active compounds including radioisotopes, polypeptides, nucleic acids, small molecules, drug molecules, and chemotherapeutic agents. In some cases, the minicell displays ligands or binding moieties that target the minicell to a desired host cell.... Agent: Vaxiion Therapeutics, Inc.

20120135502 - Novel self-dying recombinant microorganism for measuring soil and water contamination: Provided is Sphingomonas paucimobilis SQL2 having base sequences of which a sequence number is 1, being deposited with a deposition number KCTC 1171BP, and being used for specifically measuring aromatic hydrocarbons as a contaminant in a sample.... Agent: Snu R&db Foundation

20120135504 - Method for producing fungus structures: A method for growing organically derived building materials in the form of a moldable substrate that can be engineered to serve a wide range of manufacturing and construction applications is presented. In particular, the embodiments consider a plurality of fungal molded shapes preferably grown from fungal inoculum and mechanically compressed... Agent:

20120135505 - Method for preparing microcrystalline cellulose: The present invention relates to a new method for preparing microcrystalline cellulose, comprising a prior step of compaction of the cellulose before degradation of the glucose chains and obtaining the suitable degree of polymerization. It is also described that the method of the invention allows a considerable reduction in the... Agent:

20120135506 - Process for producing microfibrillated cellulose: A process for treating cellulosic fibres comprising pre-treating the fibres with an enzyme in a first enzymatic treatment followed by mechanical pre-treating the fibres in a first mechanical treatment and a second enzymatic treatment followed by a second mechanical treatment of the fibres to form micofibrillated cellulose. In this way... Agent: Stora Enso Oyj

20120135507 - Biochip module with ceramic laminate structure and method of manufacturing the same: The present disclosure provides a biochip module having a ceramic laminate structure which uses advantages of ceramic and enables a reduction in a chip area, and a method of manufacturing the same. The biochip module includes a first ceramic layer mixing bacterial water with magnetic beads to which ligands capturing... Agent: Korea Institute Of Ceramic Engineering And Technology

20120135509 - Sensor devices: The present invention relates to a sensor device for measuring a level of an analyte of interest in a fluid, such as body fluid (for example blood, plasma, urine, interstitial fluid, saliva), a method of manufacturing a sensor device, a reagent film for use in a sensor, a method of... Agent: Suresensors Ltd.

20120135508 - System and method for analyte measurement: A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon... Agent:

20120135510 - Electrokinetic device for capturing assayable agents in a dielectric fluid: Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. In one embodiment, the agents are... Agent:

20120135511 - Portable high gain fluorescence detection system: Disclosed is a compact, microprocessor-controlled instrument for fluorometric assays in liquid samples, the instrument having a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high... Agent: Micronics, Inc.

20120135512 - Light trapping optical cover: A light trapping optical cover employing an optically transparent layer with a plurality of light deflecting elements. The transparent layer is configured for an unimpeded light passage through its body and has a broad light input surface and an opposing broad light output surface. The light deflecting elements deflect light... Agent:

20120135514 - Bioreactor comprising a silicone coating: The invention relates to a bioreactor for cultivating phototrophic organisms in an aqueous culture medium. The reactor parts and/or fittings that come into contact with the culture medium are entirely or partially coated with a silicone layer, and the surface of the silicone layer has a contact angle to the... Agent: Wacker Chemie Ag

20120135513 - Bioreactor consisting of silicone materials: The invention relates to a bioreactor for cultivating phototrophic organisms in an aqueous culture medium, the reactor parts that come into contact with the culture medium being entirely or partially produced from silicone materials. The invention is characterized in that the silicone materials are produced from addition-crosslinked silicones, and the... Agent:

20120135515 - Methods for producing preparations of recombinant aav virions substantially free of empty capsids: Methods for separating AAV empty capsids from mixtures of AAV vector particles and AAV empty capsids are described. The methods use column chromatography techniques and provide for commercially viable levels of recombinant AAV virions.... Agent:

20120135516 - Artificial antibody polypeptides: A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding said monobody, and a variegated nucleic acid library encoding said monobody, are provided by the invention. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform said methods. Further provided is a method of... Agent: Novartis International Pharmaceutial Ltd.

20120135517 - Synthetic genes and genetic constructs: The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise... Agent: Commonwealth Scientific And Industrial Research Organisation

20120135518 - Defined surfaces of self-assembled monolayers and stem cells: A method for the construction of arrays from self-assembling monolayers is described. The arrays have particular utility for the screening of peptides ligands that can foster the growth of cells in culture. This technique has been used to identify peptide ligands that foster the growth of human stem cells, which... Agent:

20120135519 - Induced derivation of specific endoderm from hps cell-derived definitive endoderm: The present invention relates to a method to control differentiation of human pluripotent stem cells, including human balstocyst derived stem (hBS) cells and to obtain specific endoderm cells. In particular, present invention relates to the use of FGF2 as the key factor in a specific concentration to control differentiation of... Agent: Novo Nordisk A/s

20120135520 - Unshrunken tissue equivalent, skin equivalent comprising such an unshrunken tissue equivalent, and methods for producing such an unshrunken tissue equivalent and such a skin equivalent: The invention relates to a method for producing an unshrunken tissue equivalent. Said method is comprising in that: a mixture is produced that contains at least one element of an extracellular matrix; at least one pluridimensional medium is soaked with said mixture; from the components of the mixture, a lattice... Agent: Universite De Franche-comte

20120135521 - Antigene locks and therapeutic uses thereof: An oligonucleotide based therapeutic strategy, called anti-gene locks, is described which specifically kills cells based on their genotype. The strategy employs oligonucleotides with arms and a backbone that are complementary to both strands of the gene target. Anti-gene locks bind in vitro in a sequence dependent fashion and inhibit DNA... Agent:

20120135522 - Methods of modulating cell regulation by inhibiting p53: Disclosed herein are methods of inhibiting the function of p53 in a cell by contacting the cell with an effective amount of a PP2A inhibitor. Also disclosed herein are processes for producing an induced pluripotent stem (iPS) cell by contacting a somatic cell expressing at least one gene that encodes... Agent:

20120135523 - Preparation and uses of polyarylates: s

20120135524 - Novel nucleic acid constructs containing orthogonal site selective recombinases (ossrs): The present invention provides for a recombinant nucleic acid comprising a nucleotide sequence comprising a plurality of constructs, wherein each construct independently comprises a nucleotide sequence of interest flanked by a pair of recombinase recognition sequences. Each pair of recombinase recognition sequences is recognized by a distinct recombinase. Optionally, each... Agent: The Regents Of The University Of California

20120135525 - Reprogramming t cells and hematopoietic cells: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the... Agent:

20120135526 - Low-pressure biolistic barrels: Low pressure biolistic barrels and biolistic devices including the same are provided. Aspects of the biolistic barrels include the presence of one or more pressure-reducing elements. Also provided are kits which include the biolistic barrels, as well as methods of delivering a molecule to a target site with the biolistic... Agent:

  
05/24/2012 > 118 patent applications in 62 patent subcategories. archived by USPTO category

20120129148 - Compositions and methods for the storage of red blood cells: The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one nonmetabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Also provided are improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and... Agent:

20120129147 - Method of preparing controls for glycated hemoglobin s-a1c derived from healthy blood cells: By way of summary, the present invention meets some or all of the above needs by providing in a first aspect a method comprising contacting red blood cells in a suspension medium containing mannose under conditions such that the concentration of S-Alc glycated hemoglobin is increased to greater than about... Agent: Streck, Inc.

20120129149 - Removal of oxygen from biological fluids: A system for reducing the concentration of oxygen in a fluid including red blood cells includes a housing, a plurality of hollow tubes extending within the housing and adapted for flow of the fluid therethrough, wherein each tube includes an inlet and an outlet, and a carrier system that reduces... Agent:

20120129150 - Particles embedded in a porous substrate for removing target analyte from a sample: The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 μm, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample.... Agent: Pathogen Removal And Diagnostic Technologies Inc.

20120129156 - Barriers for facilitating biological reactions: The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.... Agent: Northwestern University

20120129153 - Diagnostic method for the prediction of the development and control of the effectiveness of the treatment of oncological illnesses: A diagnostic method, in which patient tissue samples are taken, microassay are prepared, specific anti-viral immunoglobulins are processed, the number of cells infected by two or more viruses before the beginning of treatment are determined, and the dynamic of the change in the number of infected cells and their interrelationships... Agent:

20120129152 - Diagnostic method for the prediction of the development of and control over the effectiveness of treatment of cardiovascular illnesses: A diagnostic method for the prediction of the development and control of the effectiveness of the treatment of cardiovascular diseases, in which patient tissue samples are taken, microassay are prepared, specific antiviral immunoglobulins are processed, the number of cells infected by two or more viruses before the beginning of treatment... Agent:

20120129154 - Methods and compositions for the detection of bacterial blight: Methods and compositions relating to the detection of bacterial blight are provided. In one embodiment, a detection system is provided comprising a phage operable to infect a Pseudomonas cannabina and/or Pseudomonas syringae microorganism, the phage comprising a detectable reporter configured and arranged to be expressed upon infection of the microorganism... Agent:

20120129157 - Methods and devices for rapid detection and identification of live microorganisms by aptamers and/or antibodies immobilized on permeable membranes: The invention provides methods, devices and kits for rapid detection and identification of one or more live target microorganisms in a liquid sample or grown on plates containing nutrient media. The invention includes mixing one or more target microorganisms with one or more aptamers and/or one or more antibodies, each... Agent:

20120129155 - Methods for amplifying hepatitis c virus nucleic acids: A method of amplifying an HCV nucleic acid in an HCV infected sample comprises amplifying a segment of a DNA template that is complementary to a genome of HCV RNA from the sample by a two-stage PCR, wherein a first stage PCR employs a first outer primer and a second... Agent: Vertex Pharmaceuticals Incorporated

20120129151 - Quantitative real-time assay for noroviruses and enteroviruses with built in quality control standard: A method is provided for reverse transcription-polymerase chain reaction (RT-PCR) accomplished by: a) amplifying a reverse transcribed cDNA in a mixture containing Norovirus Genogroup I and Norovirus Genogroup II primers and probes, in which the Norovirus primers and probes can distinguish between Genogroup I and Genogroup II viruses; b) quantifying... Agent: Government Of The United States, Represented By The Secretary, Department Of Health And Human

20120129162 - Cell culture system for determining the sensitizing, allergenic and/or irritating effect of a substance: The present invention refers to a cell culture system especially for investigating the sensitizing, allergenic and/or irritating effect of substances, comprising a first and a second compartment that can communicate with each other via a permeable interlayer, whereby the first compartment has an epidermis model and the second a cell... Agent: Rules-based Medicine, Inc.

20120129164 - Device and process for isolating and cultivating live cells on a filter or extracting their genetic material: The process for isolating live cells on a filter or extracting their genetic material. The process comprises the steps of attaching, at least temporarily, a filter to a lower opening of a compartment having, in addition, an air inlet; inserting into the compartment a liquid carrying the cells; and attaching,... Agent:

20120129159 - Methods and compositions for protein labeling using lipoic acid ligases: The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs (e.g., lipoic acid analogs comprising a resorufin moiety) recognized by lipoic acid ligase and lipoic... Agent:

20120129161 - Methods for modulating embryonic stem cell differentiation: Described herein is Zscan4, a gene exhibiting 2-cell embryonic stage and embryonic stem cell specific expression. Identification of nine Zscan4 co-expressed genes is also described. Inhibition of Zscan4 expression inhibits the 2-cell to 4-cell embryonic transition and prevents blastocyst implantation, expansion and outgrowth. Provided herein are methods of inhibiting differentiation... Agent: The Government Of The United States Of America As Represented By The Secretary Of The

20120129160 - Rapid in vivo gene mutation assay based on the pig-a gene: The invention relates to methods and kits for the quantitative analysis of in vivo mutation frequencies of the Pig-A gene in individuals, particularly using peripheral blood samples of vertebrates.... Agent: Litron Laboratories, Ltd.

20120129158 - Systems and methods for identifying and disrupting cellular organelles: This invention relates to optomechanical systems and methods for altering, modifying or disrupting a target object. Such systems and methods are used for, for example, ablating the endogenous nucleus in a cell.... Agent: The Regents Of The University Of California

20120129163 - Testing lumenectomy samples for markers of non-vascular diseases: Lumenectomy material is tested to determine the presence or likelihood of a condition of a patient. The lumenectomy material is in the form of at least one continuous tissue strand collected in vivo from an inner surface of a body lumen of the patient. The presence of at least one... Agent: Tyco Healthcare Group Lp

20120129171 - Genetic markers for assessing risk of developing bipolar disorder: This document provides methods and materials related to genetic markers of Bipolar Disorder (BD) and Schizophrenia (SZ). For example, methods for using such genetic markers to assess risk of developing BD and/or SZ are provided, as are methods for making a differential diagnosis between BD and SZ.... Agent: Suregene, LLC

20120129165 - Imaging individual mrna molecules using multiple singly labeled probes: A method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non-overlapping probe binding regions of 15-100 nucleotides, comprising immersing said cell in an excess of at least 30 nucleic acid hybridization probes, each singly labeled... Agent: University Of Medicine And Dentistry Of New Jersey

20120129172 - Method for selecting clone of induced pluripotent stem cells: To efficiently identify and select a clone from clones of induced pluripotent stem cells (iPS cell) having low tumor formation rate in vivo when allowed to differentiate and transplanted in a living body, iPS cells of the clones are induced to differentiate, undifferentiated cells among the cells after the induction... Agent: Kyoto University

20120129166 - Method of detecting fungi belong to genus geosmithia:

20120129170 - Methods for identifying genomic deletions: The genomic locus responsible for Van Buchem's disease is narrowed to an approximately 92 kb region of human chromosome 17 at 17q21. Individuals afflicted with or carriers of Van Buchem's disease exhibit a 52 kb deletion within this 92 kb region. Methods are provided that permit the differentiation between individuals... Agent: Celltech R&d Inc.

20120129173 - Recombinase polymerase amplification reagents and kits: This disclosure describes kits, reagents and methods for Recombinase Polymerase Amplification (RPA) of a target DNA that exploit the properties of re-combinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed kits, reagents and methods have the... Agent: Alere San Diego, Inc.

20120129174 - Target sequence amplification method, polymorphism detection method, and reagents for use in the methods: An object of the present invention is to provide an amplification method that inhibits amplification caused by erroneous annealing of a primer. Primers X1 and X2 are used in amplification of a target sequence including a target site showing a polymorphism. The primer X1 includes a sequence A1′ and a... Agent: Arkray, Inc.

20120129167 - Truncated cd20 protein, deltacd20: The present invention relates in particular to a protein from an alternative splicing of the gene encoding CD20, the nucleic acid sequences encoding the protein according to the invention, a mutated form of the CD20 gene as well as drugs, diagnostic tools, diagnostic methods and treatment methods using the protein... Agent: Etablissement Francais Du Sang (efs)

20120129168 - Tumor marker and use thereof: The present invention detects SNX5 in a sample from a subject. The SNX5 is used as a tumor marker specific to papillary thyroid carcinoma, whereby diagnosis of papillary thyroid carcinoma is carried out easily. The present invention provides also a technique of discriminating papillary thyroid carcinoma using the tumor marker.... Agent:

20120129169 - Two-step cold formalin fixation of organic tissue samples: A method for fixation of organic tissue samples includes immersing a tissue sample in a solution of Formalin at a temperature of between 2° C. and 10° C. for a first time period (A), and immersing the tissue sample in a cold fixation dehydrating agent for a second time period... Agent: Milestone S.r.l

20120129182 - Amplification of complex nucleic acids: What is described is a method for quantitative and qualitative analysis of complex template nucleic acids to be analyzed. The method comprises the co-amplification of a control nucleic acid with the complex template nucleic acid by means of isothermal strand displacement reaction. The method of the invention further comprises the... Agent: Qiagen Strasse 1

20120129176 - Cytokines as prognostic markers of respiratory-tract infection following major surgery: The invention relates to the use of a certain subset of cytokine markers as prognostic variables of infection status in an individual, and especially as prognostic markers of a patients developing severe infection such as pneumonia, and respiratory tract infection following surgery. The subset of cytokine markers consists of the... Agent: The Provost. Fellows And Scholars Of The College

20120129181 - Detection of bacterial (mollicutes) contamination: The present disclosure provides a method and system for the PCR amplification of a target sequence which suppresses non-specific amplification products. The disclosure concerns the use of a primer pair optimized to amplify a nucleic acid of a contaminant in the background of genomic DNA of a first organism. When... Agent: Roche Diagnostics Operations, Inc.

20120129177 - Evaluation of the potential risk of drug induced mood disturbance and suicide: use of a dedicated platform: The present invention relates to in vitro methods for the determination of the potential toxicity of test compounds. The invention also comprises in vitro methods for the selection of therapeutical compounds useful for the treatment of pathology related to an alteration of the mechanism of the mRNA editing of ADAR... Agent: Biocortech

20120129178 - Genomic polymorphism for predicting therapeutic response: The present invention relates to the use of genomic polymorphism to provide individualized therapeutic regimens to treat patients suffering from diseases such as cancer. The invention discloses methods for determining the efficacy or choice of chemotherapeutic drugs and regimens for use in treating a diseased patient by associating genomic polymorphism... Agent: University Of Southern California

20120129180 - Method and a kit for detecting antibiotic resistant bacteria: The present invention relates to a method and kit for detecting carbapenemase resistance genes causing carbapenem resistance in bacteria. The invention provides oligonucleotide primers, which can be used in the detection. The method can be used to detect OXA-48, SME, GIM-1, VIM 1-22, SPM, GES 1-10, KPC 1-7, IMI 1-3/NMC-A,... Agent:

20120129175 - Method for renal disease diagnosis and prognosis using annexin a1 and rab23 as markers: Use of Annexin A1 or Rab23 as a biomarker for diagnosing kidney disease or assessing efficacy of kidney disease treatment.... Agent: National Defense Medical Center

20120129183 - Methods and kits for isolating placental derived microparticles and use of same for diagnosis of fetal disorders: A prenatal method of analyzing a fetus is disclosed. The method comprising: (a) isolating placental derived microparticles; and (b) analyzing at least one component of the contents of the placental derived microparticles, wherein the at least one component is indicative of a characteristic of the fetus.... Agent: Fund For Medical Research Development Of Infrastructure And Health Services

20120129179 - Scn5a splicing factors and splice variants for use in diagnostic and prognostic methods: Provided herein are methods of identifying a subject at risk for arrhythmias, heart failure or sudden cardiac death. In exemplary aspects, the method comprises the step of determining a level of splicing factor hLuc7a, splicing factor RBM25 and/or PERK in a biological sample obtained from the subject, wherein an increased... Agent: The Board Of Trustees Of The University Of Illinois

20120129184 - Systemic carnitine deficiency gene and uses thereof: The gene responsible for systemic carnitine deficiency was found to be the OCTN2 gene involved in the transportation of organic cations. This invention enables tests for this disease by detecting whether or not the OCTN2 gene has a mutation. Furthermore, systemic carnitine deficiency can be treated using the normal OCTN2... Agent: Chugai Seiyaku Kabushiki Kaisha

20120129189 - Methods of controlling cell proliferation: The present disclosure provides methods for increasing self-renewal/expansion of stem cells. The present disclosure provides methods of reducing uncontrolled cell proliferation. The present disclosure provides methods of identifying agents that modulate Notch1/-catenin binding, and methods of identifying agents that inhibit enzyme-mediated cleavage of Notch1 intracellular domain from Notch1 transmembrane domain.... Agent:

20120129192 - Apparatus and methods for detection of tumor cells in blood: In one embodiment, the present invention provides the description of an inexpensive and disposable handheld device for detecting Circulating tumor cells (CTC) in blood called a handheld CTC detector (HCTCD). The HCTCD is capable of detecting less than 1 CTC per milliliter. The HCTCD consists of a dense array of... Agent: Nauganeedles LLC

20120129191 - Cocktail antibody, determination kit and determination method for determining histological type of carcinoma: The cocktail antibody is used to determine the histological type of lung carcinoma, and includes an ADC cocktail antibody that shows an antigen-antibody reaction with Napsin-A that is localized in cytoplasm of adenocarcinoma and TTF-1 that is localized in a cell nucleus of adenocarcinoma, and an SCC cocktail antibody that... Agent: National University Corporation University Of Toya

20120129190 - Ensemble-decision aliquot ranking: Provided herein, among other aspects, are methods and apparatuses for ranking aliquots from a suspension containing bioparticles. In certain embodiments, the bioparticles may be cells, organelles, proteins, DNAs, debris of biological origin, microbeads coated with biological compounds, or viral particles. As such, the methods and apparatuses provided herein may be... Agent:

20120129193 - Device and method for analysing cells: There is provided a carrier substrate for nonspecific immobilization of living bacterial and/or eukaryotic cells, especially of animal cells, which can be present as single cells, cell agglomerates or tissue sections. The surface of the carrier substrate is provided at least sectionally with a layer having or consisting of oligonucleic... Agent: Medizinische Hochschule Hannover

20120129194 - Visible detection of microorganisms: Methods of detecting very low levels of targets, such as cells, are provided. In some embodiments, for example, the methods can detect bacteria present in a sample at concentrations less than 25 cells/mL. The method involves detecting nanoparticle aggregation in the absence of the target.... Agent: Wisconsin Alumni Research Foundation

20120129186 - Devices and methods for the diagnosis and treatment of wounds using biomarkers: The present invention provides for devices and methods for determining the healing phase of a wound. In some aspects, the present invention provides a wound diagnosis device comprising a surface and at least one agent that is specific to a desired biomarker. In another aspect, the present invention provides a... Agent: Kci Licensing, Inc.

20120129187 - Diagnostical use of peroxiredoxin 4: The present invention relates to a method for the diagnosis or prognosis of a disease or clinical condition in a subject comprising the steps of: (i) providing a sample of bodily fluid of a subject, (ii) determining the level of peroxiredoxin 4 (PRX4) or a fragment thereof having at least... Agent: B.r.a.h.m.s. Gmbh

20120129185 - Methods and compositions for diagnosing ankylosing spondylitis using biomarkers: The invention provides a method for determining the efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a collagen degradation biomarker and/or a synovitis biomarker.... Agent: Abbott Biotechnology Ltd.

20120129188 - Circulating cytochrome c as biomarker of reperfusion injury and responsiveness to mitochondrial targeted interventions: The present invention relates generally to the use of circulating cytochrome c as a biomarker of reperfusion injury that results from whole body ischemia. Circulating levels of cytochrome c can be used as predictor of survival rates and to assess the effects of interventions aimed at ameliorating mitochondrial injury during... Agent: Rosalind Franklin University Of Medicine And Science

20120129199 - Compositions, kits and methods for in vitro antigen presentation, assessing vaccine efficacy, and assessing immunotoxicity of biologics and drugs: Nanoparticle-based compositions, assays, kits, methods and platforms for delivering an antigen (peptides, proteins) or a nucleic acid encoding an antigen to professional APCs (PAPCs) result in the generation of autologous APCs that present a natural peptide repertoire of the antigen for use in assessing the efficacy of a vaccine (e.g.,... Agent: University Of Miami

20120129196 - Highly sensitive monoclonal antibody residual detection assay: The present invention relates to compositions and highly sensitive methods for the detection of biotechnology product residual when monitoring product carry over and/or for cleaning verification in the manufacture of biotechnology products. In particular, the present invention is directed to immunoassays wherein one or more capture antibodies, or antigen binding... Agent: Abbott Laboratories

20120129197 - Immunomodulation of functional t cell assays for diagnosis of infectious or autoimmune disorders: Improved assays for detecting the presence of a specific cell-mediated immune response in an individual are provided, where a sample comprising T cells and other cells of the immune system, usually a blood sample or derivative thereof, is contacted with test antigen(s) of interest in the presence of a pattern... Agent:

20120129195 - Method of quick laboratory diagnosis if illnesses based on the discovery of specific proteins and equipment for its implementation: A method of quick laboratory diagnosis of diseases, based on the discovery of specific protein targets characteristic to the disease in the reaction of their specific interaction with other protein reagents, distinct in that specific protein targets for the given disease are hydrolyzed with proteolytic enzymes and then the chemical... Agent:

20120129198 - Novel methods for the assay of troponin i and t and complexes of troponin i and t and selection of antibodies for use in immunoassays: m

20120129200 - Prodefensin-a6 assay method for the in vitro diagnosis of colorectal cancer: The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Prodefensin-A6 tumour marker in a biological sample taken from a patient suspected of having colorectal cancer, it being possible for said method to be used both in early diagnosis,... Agent: Biomerieux

20120129202 - Composition for assaying glycated proteins: Compositions for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) stabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while avoiding the effects of glycated hemoglobin, and an assay method are... Agent:

20120129201 - Mass spectrometry imaging with substance identification: A method for the identification and localization of proteins or other biomolecules of a histologic tissue section comprises enzymatically digesting the biomolecules of two similar tissue sections while substantially preserving the biomolecule positions in the tissue sections. Next, a mass spectrometric image of the digest products in one of the... Agent: Bruker Daltonik Gmbh

20120129203 - Novel peptidase substrates: m

20120129204 - Novel nitroreductase enzymatic substrates: The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or... Agent: Biomerieux, Sa

20120129205 - Novel nitroreductase enzymatic substrates: e

20120129206 - Method of identifying patients suitable for high-dose cyclophosphamide treatment: The present invention provides methods of identifying subjects that are suitable for high-dose cyclophosphamide treatment.... Agent: The Johns Hopkins University

20120129209 - Aligning cells on wrinkled surface: A method is provided for preparing an aligned cell population comprising the culturing one or more cells on a surface having a texture, which texture has an average height of from about 100 nanometers to about 5 micrometers, thereby forming an aligned cell population on the textured surface. Also provided... Agent: The Regents Of The University Of California

20120129207 - Compositions and methods of functionally enhanced in vitro cell culture system: Compositions and methods described herein provide a cell culture system in which cells are in high metabolic states from the onset of the culture. Combinations of various cell culture components disclosed and employed herein allow cells to be in high metabolic states useful for drug testing immediately after the start... Agent: Hurel Corporation

20120129208 - Honeycomb shrink wells for stem cell culture: This invention provides a microwell array having a plurality of microwells on a hydrophobic surface wherein the microwells each is substantially proximate to each of its adjacent microwells, as well as methods to prepare arrays. Also provided is a plate that comprises at least one microarray, at least one input... Agent:

20120129210 - Method for assaying inositol hexaphosphate (ihp): The invention relates to a method for assaying inositol hexaphosphate (IHP) in a product that can be injected in humans or animals or in a fraction of this product, in which a metal compound is added to a sample or a fraction of this product and the complexation of said... Agent:

20120129212 - Method of monitoring erythropoiesis: The invention relates to methods of monitoring erythropoiesis. In particular, the invention relates to methods of detecting nascent erythrocyte production in vivo as methods for identifying modulators of erythropoiesis.... Agent: Vertex Pharmaceuticals Incorporated

20120129211 - Titration of differentiation medium components: Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including screening of optimal differentiation conditions for a selected stem cell clone in a selected batch of culture medium and use of the determined optimal condition for differentiation into a specific cell lineage.... Agent:

20120129213 - Multi-spectral imaging including at least one common stain: A method including: providing a sample with M components to be labeled, where M>2; labeling the components with N stains, where N<M so that at least two components are labeled with a common stain; obtaining a set of spectral images of the sample; classifying different parts of the sample into... Agent:

20120129215 - Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing... Agent: The Scripps Research Institute

20120129216 - Enzymatic antibody processing: The current invention comprises a method for producing an immunoglobulin or immunoglobulin fragment with defined glycostructure comprising the following steps: a) providing an affinity chromatography column eluate containing the immunoglobulin or immunoglobulin fragment, b) incubating the affinity chromatography column eluate with (α1,3)galactosidase of plant origin, e.g. from green coffee beans... Agent:

20120129214 - Peptide synthesis using enzymatic activation an coupling: Method for enzymatically synthesising a peptide, comprising enzymatically preparing an ester or a thioester from (i) an N-terminal protected amino acid, an N-terminal protected amino acid C-terminal ester, an N-terminal protected peptide, or an N-terminal protected peptide C-terminal ester and (ii) an alcohol represented by the formula HO—CX2—Z respectively a... Agent:

20120129217 - Polypeptide expression in ciliates: This invention is directed to methods for recombinant polypeptide production and, in particular, methods and products for the production of recombinant polypeptides in ciliates.... Agent:

20120129218 - Cofilin knockdown host cells and uses thereof: The present invention relates to a host cell comprising a cofilin-specific small interfering RNA (siRNA) sequence. The host cell may further comprise a nucleic acid encoding a recombinant protein. The present invention also relates to a method for producing a recombinant protein by the host cell comprising a cofilin-specific small... Agent: University Of Delaware

20120129219 - Antibody molecules which bind human il-17: The invention relates to antibody molecules having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecules and methods of producing the antibody molecules.... Agent: Ucb Pharma S.a.

20120129220 - Process for production of useful substance, and surfactant for use in the process: The present invention is aimed to provide a method for industrially producing a useful substance (protein etc.) utilizing a bacterium such as Escherichia coli in the presence of a surfactant and a surfactant to be used in this method for producing a useful substance. The present invention is a method... Agent: Sanyo Chemical Industries, Ltd.

20120129221 - Biochemical platform for fuels and chemicals production from cellulosic biomass: An alternative biochemical process for fuels and chemicals production from cellulosic biomass is presented. The method includes an aerobic step where microorganisms convert carbohydrates contained in cellulosic biomass into sugar acids, which can be converted to fuels and chemicals, including ethanol, gluconate, and acetic acid, via fermentation.... Agent: The Regents Of The University Of California

20120129222 - Mutant formate dehydrogenase, gene encoding the same, and method for producing nadh: Durability of formate dehydrogenase is improved with the use of formate dehydrogenase exhibiting high specific activity that is unpredictable from conventional findings. A specific amino acid substitution is introduced into Gibberella zeae-derived formate dehydrogenase. Mutant formate dehydrogenase exhibits durability that is extremely superior to that of wild-type formate dehydrogenase. Thus,... Agent: Toyota Jidosha Kabushiki Kaisha

20120129224 - Method and apparatus for changing one type of cell into another type of cell: A method and apparatus converts host cells of a first type into cells of a second type when the host cells are placed in intimate contact with donor cells of the second type. Under predetermined conditions there is transport of a sufficient number of mRNA molecules from the donor cells... Agent:

20120129223 - Dna loaded supported gold nanoparticles, process for the preparation and use thereof: The present invention relates to DNA loaded gold nanoparticles embedded in sharp carbonaceous carriers useful for higher DNA delivery efficiently into plants. These nanogold embedded carbon matrices are prepared by heat treatment of biogenic intracellular gold nanoparticles. The DNA delivery efficiency is tested on model plants. These materials reveal good... Agent: Council Of Scientific & Industrial Research

20120129225 - Methods and reagents for molecular cloning: The present invention provides compositions, methods, and kits for covalently linking nucleic acid molecules. The methods include a strand invasion step, and the compositions and kits are useful for performing such methods. For example, a method of covalently linking double stranded (ds) nucleic acid molecules can include contacting a first... Agent: Life Technologies Corporation

20120129227 - Thermostable cellulases, and mutants thereof, capable of hydrolyzing cellulose in ionic liquid: The present invention provides for a composition comprising an ionic liquid and a thermostable cellulose, and a method of hydrolyzing a cellulose, comprising: (a) providing a composition comprising a solution comprising an ionic liquid and a cellulose, and (b) introducing a thermostable cellulase to the solution, such that the cellulose... Agent: The Regents Of The University Of California

20120129226 - Trichoderma reesei alpha-amylase is a maltogenic enzyme: A maltogenic a-amylase from Trichoderma reesei (TrAA) and variants thereof are useful in the production of high-maltose syrups from liquefied starch. Particularly high maltose concentrations are achieved when TrAA is used in the presence of a pullulanase. Expression hosts and encoding nucleic acids useful for producing TrAA and its variants... Agent:

20120129228 - Bacterial cellulose based 'green' composites: ‘Green’ composites are fabricated using resins, such as soy-based resins, and reinforced with crystalline high strength bacterial cellulose (BC) fibers. Bacterial cellulose is produced by providing a bacterial cellulose-producing bacterium such as Acetobacter xylinum; providing an inexpensive bacteria nutritional medium; culturing the bacterium in the bacteria nutritional medium under conditions... Agent:

20120129229 - Yeast expressing cellulases for simultaneous saccharification and fermentation using cellulose: Host cells, comprising Kluveryomyces expressing heterologous cellulases produce ethanol from cellulose In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose The recombinant yeast strains and co-cultures of the yeast strains can be used to produce ethanol on their own,... Agent:

20120129230 - Genetically modified yeast of the species issatchenkia orientalis and closely related species, and fermentation processes using same: Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.... Agent:

20120129231 - Engineering of thermotolerant bacillus coagulans for production of d(-)-lactic acid: Genetically modified microorganisms having the ability to produce D(−)-lactic acid at temperatures between 30° C. and 55° C. are provided. In various embodiments, the microorganisms may have the chromosomal lactate dehydrogenase (ldh) gene and/or the chromosomal acetolactate synthase (alsS) gene inactivated. Exemplary microorganisms for use in the disclosed methods are... Agent: University Of Florida Research Foundation, Inc.

20120129232 - Polyhydroxyalkanoate production from polyols: Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase β-ketothiolase, acetoacetyl-CoA reductase, PHA synthase, glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase, which are useful for the production of PHAs. In some cases one or more of these genes are native to the host organism and the... Agent: Metabolix, Inc.

20120129233 - Method for producing an organic acid: An organic acid is produced by allowing a bacterium belonging to the family Enterobacteriaceae, which has an ability to produce an organic acid and has been modified so that the phosphoenolpyruvate carboxykinase activity is enhanced, and the glucose phosphotransferase activity is decreased, which is selected from Escherichia, Enterobacter, Pantoea, Erwinia,... Agent:

20120129234 - System for treatment of biomass to facilitate the production of ethanol: A method for treating fermented lignocellulosic biomass to be supplied to a distillation system for production of ethanol is provided. The method includes pre-treating lignocellulosic biomass into pre-treated biomass and separating the pre-treated biomass into a liquid component comprising sugars and a solids component comprising cellulose and lignin. The method... Agent: Poet Research, Inc.

20120129235 - System for treatment of biomass to facilitate the production of ethanol: The present invention is directed to novel methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethylspiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. Provided are methods for production of premnaspirodiene from a terpene substrate, methods for production of 5-epi-β-vetivone from premnaspirodiene as starting material, and methods for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and... Agent:

20120129236 - Formulation and process for co2 capture using amino acids and biocatalysts: A formulation and a process for CO2 capture, where a CO2-containing gas in contacted with water, biocatalyst and an amino acid compound, enabling the dissolution and transformation of the CO2 into bicarbonate ions and hydrogen ions, producing an ion-rich solution and a CO2-depleted gas. The amino acids may present slow... Agent: Co2 Solutions Inc.

20120129237 - Polynucleotides encoding novel pcsk9 variants: The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the... Agent: Bristol-myers Squibb Company

20120129238 - Reverse transcriptase mixtures with improved storage stability: Reverse transcriptase mixtures with improved storage stability are provided.... Agent: Bio-rad Laboratories, Inc.

20120129239 - Homologous recombination-based dna cloning compositions: Methods and compositions for cloning a donor DNA molecule into an acceptor vector at a predetermined location are described. The methods are based on homologous recombination mediated by in vitro treatment of the donor DNA and the acceptor vector with an enzyme cocktail containing an exonuclease and a single-stranded DNA... Agent: Genscript Holdings (hong Kong) Limited

20120129240 - Buffer compounds: t

20120129241 - An l-arabinose fermenting yeast: An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the... Agent: Alliance For Sustainable Engergy, LLC

20120129243 - Algae producing trough system: A trough lining assembly is placed in a series of troughs at a biomass processing facility. The trough lining assembly includes a waterproof liner that lies against the sides of a trough, an aerator, and a retention mechanism that retains the aerator at the bottom of the trough. The aerator... Agent: Phyco Biosciences, Inc.

20120129245 - Algae reactor: The invention relates to a lighting system for illuminating algae in an aqueous liquid. The lighting system includes a light source comprising a plurality of LEDs, a mounting structure for supporting the LEDs and a housing for accommodating the light source and the mounting structure. At least a portion of... Agent: Tendris Solutions B.v.

20120129242 - Falling film evaporator: An apparatus and method are disclosed for controlling the thickness of a flowing, laminar fluid film. The film flow may be gravity-induced or the result of an alternative force. The fluid is deposited on an upper end of a flow surface where a relatively thick layer of the film forms.... Agent:

20120129244 - Systems, methods and apparatuses for dewatering, flocculating and harvesting algae cells: Described herein are systems, methods and apparatuses, for dewatering, flocculating and harvesting microorganisms. In various implementations, at least one intracellular product from the microorganisms is recovered and processed according to methods disclosed herein. In some implementations, an electromagnetic field is applied to an aqueous suspension of microorganisms thereby causing flocculation... Agent:

20120129246 - Formulation and process for co2 capture using carbonates and biocatalysts: A formulation and process for capturing CO2 use an absorption mixture containing water, biocatalysts and a carbonate compound. The process includes contacting a CO2-containing gas with the absorption mixture to enable dissolution and transformation of CO2 into bicarbonate and hydrogen ions, thereby producing a CO2-depleted gas and an ion-rich solution,... Agent: Co2 Solutions Inc.

20120129247 - Sample analyzer: A sample analyzer for analyzing a sample with a liquid in a container is disclosed. The sample analyzer comprises: a reader that reads an information of a liquid in a container, the information of the liquid being stored in a storage medium; a display; and a controller including a processor... Agent:

20120129248 - Assay tools and methods of use: The present invention provides assay tools for the detection of biological or chemical activity in a sample. The assay tools of the invention provide direct detection using a positive signal generated on a surface of the assay tool. These assay tools provide improved methods for detection and/or identification of multiple... Agent: Prognosys Biosciences, Inc.

20120129249 - Stirring apparatus for stirring microorganisms in a culturing medium: The invention provides a stirring apparatus for stirring microorganisms such as, an alga in a culturing medium. The stirring apparatus includes one or more supporting structures. The stirring apparatus further includes a plurality of paddle units operatively connected to the one or more supporting structures. The plurality of paddle units... Agent: King Abdul Aziz City For Science And Technology

20120129250 - Microtitration plate: A microtitration plate, having a frame made of a plastic which has a plate with a multiplicity of holes, and a multiplicity of receptacles made of the same plastic which are fixedly connected to the plate at the holes by directly molding them thereto, have a receiving portion protruding from... Agent:

20120129253 - Adipose tissue-derived stromal cells and methods of isolating and using the same: Adipose tissue-derived stromal cells and methods of isolating and using the same. In at least one embodiment of isolated adipose tissue-derived stromal cells of the present disclosure, the cells are isolated by performing adipose tissue resection or suction on a mammalian patient, dissecting tissue obtained from said tissue resection or... Agent:

20120129252 - Method and system for cell filtration: Methods and systems disclosed in the present application include membrane-like filters and methods and systems that employ these membrane-like filters to isolate circulating tumor cells and other abnormal cells from biological fluids, such as blood. The disclosed methods and systems use membrane-like filters that include a pattern or array of... Agent:

20120129251 - Method for deparaffinizing formalin-fixed paraffin-embedded tissue: The invention provides a method for deparaffinizing a formalin-fixed paraffin-embedded tissue, including: providing a formalin-fixed paraffin-embedded tissue sample; mixing the formalin-fixed paraffin-embedded tissue sample with an organic solvent and water or with an organic solvent and an aqueous solution to form a mixture, wherein a density of the organic solvent... Agent: Industrial Technology Research Institute

20120129254 - Inducible expression system transcription modulators comprising a distributed protein transduction domain and methods for using the same: Aspects of the invention include inducible expression systems in which a transcription modulator having a distributed protein transduction domain is employed. Aspects of the invention further include methods of using the systems to induce expression of a coding sequence, as well as kits that find use in practicing methods of... Agent:

20120129255 - Functionalization of silk material by avidin-biotin interaction: The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such... Agent: Trustees Of Tufts College

20120129256 - Method of preparing pluripotent stem cells: The invention relates to biotechnology, and particularly to the preparation of pluripotent stem cells. The method involves introduction into umbilical cord and placental stem cells of RNA with at least one sequence which ensures the transition of cells to the pluripotent state. The method enables to effectively prepare pluripotent stem... Agent:

20120129257 - Apparatus for culturing anchorage dependent cells: The invention relates to an apparatus (1) for culturing anchorage-dependent cells. The apparatus (1) comprises a housing (2) with an inlet (4) and an outlet (5), and a plurality of culture plates (6) removably stacked within the housing (2). The housing (2) has a circumferential wall (7), a base (8)... Agent: Agency For Science, Technology And Research

20120129258 - Cell chip and method of fabricating the same: Disclosed herein are a cell chip and a method of fabricating the same. The cell chip includes a cell-adhesivecell-adhesive layer disposed on a substrate. Photocrosslinked polymer barriers are disposed on the cell-adhesivecell-adhesive layer. The photocrosslinked polymer barriers may serve to restrict and grow cells only on the cell-adhesivecell-adhesive layer exposed... Agent: Electronics And Telecommunications Research Institute

20120129259 - Method for producing a coated cell culture carrier: The present invention relates to a method for producing a coated cell culture carrier, wherein a solution comprising a polyurethane urea is applied to a cell carrier and dried. The polyurethane urea is produced beforehand by converting at least one polycarbonate polyol component, at least one polyisocyanate component, and at... Agent: Bayer Materialscience Ag

20120129260 - Method for producing pluripotent stem cells: Methods are provided for producing a human embryo capable of developing to the blastocyst stage. The method includes transferring a human somatic cell genome into a mature human oocyte by nuclear transfer and activating the oocyte, without removing the oocyte genome. Pluripotent human embryonic stem cells, and methods of obtaining... Agent: The New York Stem Cell Foundation

20120129262 - Methods of modifying transcriptional regulatory networks in stem cells: The vast differentiation potential of human embryonic and induced pluripotent stem cells, including their potential to cascade through all of the somatic cell lineages and to display the complete transcriptional regulatory network of human biology, has generated interest in deriving scalable, purified, and identified cell types and methods of discovering... Agent:

20120129261 - Transcriptome transfer produces cellular phenotype conversion: The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.... Agent: The Trustees Of The University Of Pennsylvania

20120129263 - Recombinant viral vector for gene transfer into lymphoid cells: A recombinant herpesvirus, a method for producing the recombinant herpesvirus, and a pharmaceutical composition comprising the recombinant herpesvirus, are provided with a method for producing a recombinant herpesvirus using a BAC vector sequence. In addition, a vector comprising a herpesvirus genomic gene and a BAC vector sequence, a cell comprising... Agent: The Research Foundation For Microbial Diseases Of Osaka University

20120129264 - Method for transforming a bacterium belonging to the streptococcus genus by natural competence: The present invention relates to peptides, nucleic acids and methods for transforming a bacterium belonging to the Streptococcus genus by natural competence and their use in the food and feed industry.... Agent: Danisco A/s

  
05/17/2012 > 155 patent applications in 85 patent subcategories. archived by USPTO category

20120122071 - Method of processing allograft skin for transplantation, and cryopreserved allograft skin produced thereby: The present invention relates to a method of processing allograft skin for transplantation and a cryopreserved allograft skin produced thereby. More specifically, the present invention relates to a method in which a cryoprotectant is prepared by adding sucrose to basic constituents comprising dimethyl sulfoxide, an animal cell culture medium and... Agent:

20120122073 - Cis di-ahl modified controls for glycated hemoglobin s-a1c derived from healthy blood cells: The invention is composition comprising red blood cells in an aqueous suspension medium and one or more cis di-ahls; wherein more than 6 percent by weight of the hemoglobin in the red blood cells is S-Alc glycated hemoglobin. In another embodiment, the invention is a method comprising contacting red blood... Agent: Streck, Inc.

20120122072 - Method and system for heating and/or thawing blood products: A device for heating one or more blood product units using electromagnetic (EM) energy is disclosed. The device comprises a chamber sized and shaped for containing at least one frozen blood product unit, a dielectric heating unit for applying electromagnetic (EM) energy at a plurality of frequencies to the at... Agent: Rf Dynamics Ltd.

20120122074 - Mail screening to detect mail contaminated with biological harmful substances: A multi-tier approach for use in a mailroom for detecting bio-threats conveyed by mail. In a first tier procedure, mail entering the mailroom is continuously automatically screened at a mail screening station to detect a potential bio-threat contamination. If a potential bio-threat is detected, an alarm signal is generated, a... Agent: Mesosystems Technology, Inc.

20120122075 - System and method for detecting threatening agents in the air: A multi-tier approach for use in a detecting harmful agents conveyed by the air. In a first tier procedure, the air (in a structure or a predefined area) is continuously automatically screened at a plurality of different predefined locations by air sensors distributed in the area to be monitored. Each... Agent: Mesosystems, Inc.

20120122077 - Method to detect and sequence post translationally modified peptides: A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed.... Agent: Micromass Uk Limited

20120122076 - Purification of antibodies using simulated moving bed chromatography: The present invention relates to compositions and methods for the chromatographic purification of antibodies, such as monoclonal antibodies, employing improved simulated moving bed separation strategies and, in certain embodiments, Raman spectroscopy.... Agent: Abbott Laboratories

20120122081 - Differentiating picorna viruses, nucleic acids therefor, use thereof and bioassay methods employing them: A nucleic acid comprising a 13 base sequence selected from the group consisting of tcGg TtccgCt Gc, tcGgTtccgCc Ac, tcGgTcCcaTcCc, tcGgTtCcaTcCc, ttGgTcCcaTcCc, ttGgTtCcaTcCc, tcGgTcccgTcCc, and tcGgTtccgTcCc, where A and a are adenine, C and c are cytosine, G and g are guanine, and T and t are thymine or uracil,... Agent:

20120122080 - Fluorescence energy transfer by competitive hybridization: A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which have a fluorophore on one probe and a quencher on the other. The fluorophore and quencher are... Agent: Quest Diagnostics Investments Incorporated

20120122079 - Infection detection methods and systems and related compounds and compositions: m

20120122082 - Method and kit for detection of microorganism:

20120122078 - Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (cin) lesion from a suspension sample of cervical cells: Methods of predicting whether a subject has a cervical intraepithelial neoplasia (CIN) lesion are provided. Aspects of the methods include obtaining both morphometric and biomarker data from a liquid cervical cellular sample and then using both types of data to predict whether the subject has a CIN lesion. Also provided... Agent:

20120122083 - Expression vector for producing protein derived from foreign gene in large quantity using animal cells, and use thereof: The present inventors conducted dedicated studies and successfully constructed expression vectors that enable high-level production of foreign gene-derived proteins in mammalian host cells, which comprise a translation-impaired dihydrofolate reductase gene cistron whose expression has been attenuated by altering the codons to the least frequently used codons in mammals; and a... Agent:

20120122085 - Recql4/recql4 variant-p53 complex for altered mitochondrial function in rothmund-thomson syndrome: The present invention discloses a functional interaction of the p53 with RECQL4/RECQL4 variant. The present invention further discloses co localization of RECQL4/RECQL4 variant and p53 complex in the mitochondrial nucleoids. The MLS at the N-terminus of RECQL4 that binds to Tom 20 receptor complex and transport RECQL4/RECQL4 variant-p53 complex into... Agent: National Instutute Of Immunology

20120122084 - System for identifying and sorting living cells: In embodiments of the present invention, a system and method of cytometry may include presenting a single sperm cell to at least one laser source configured to deliver light to the sperm cell in order to induce bond vibrations in the sperm cell DNA, and detecting the signature of the... Agent: 1087 Systems, Inc.

20120122087 - 5-hydroxymethylcytosine as a biomarker for early detection, treatment and prognostic monitoring of cancer: The present invention is related to the use of 5-hydroxymethylcytosine or a biomolecule having general structure of 5-hydroxymethycytosine as a biomarker for the detection, treatment monitoring, and prognostic prediction of cancer.... Agent:

20120122091 - Biological sampling device: A sampling device adapted for transcervical sampling of biological materials from a pregnant patient comprising: an elongate insertion tube (4) having a first end (5) adapted for insertion through the external orifice (external os) of said patient's cervix and a second end (6) including a handle means (7) for manipulating... Agent: Genetic Technologies Limited

20120122094 - Composition and method for stabilizing fluorescent particles: Embodiments of a composition for stabilizing fluorescent signal of nanoparticles and methods for its use are disclosed. In some embodiments, the composition has a pH from 7 to 10 and includes borate, protein and/or protein hydrolysate, an amine, a preservative, and a nonionic surfactant. In particular embodiments, the amine is... Agent:

20120122092 - Compositions and methods for detecting borrelia afzelii: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the p24 gene for the outer surface protein of... Agent: Medical Diagnostic Laboratories, LLC

20120122089 - Gene marker for evaluating genetic potential for marbling in bovine individual and method for evaluating genetic potential for marbling using the same: The present invention provides markers for evaluating a genetic potential for marbling of a bovine individual as well as methods for evaluating genetic potential for marbling using the markers.... Agent: Japan Livestock Technology Association

20120122090 - Gene methylation in cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of cancer.... Agent: Orion Genomics LLC

20120122086 - Method for rapid detection and identification of bioagents in epidemiological and forensic investigations: The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.... Agent: Isis Pharmaceuticals, Inc.

20120122093 - Methods and kits for multiplex amplification of short tandem repeat loci: Compositions, methods and kits are disclosed for use in simultaneously amplifying at least 20 specific STR loci of genomic nucleic acid in a single multiplex reaction, as are methods and materials for use in the analysis of the products of such reactions. Included in the present invention are materials and... Agent: Life Technologies Corporation

20120122088 - Methylation assay: A method for detecting a methylated genomic locus is provided. In certain embodiments, the method comprises: a) treating a nucleic acid sample that contains both unmethylated and methylated copies of a genomic locus with an agent that modifies cytosine to uracil to produce a treated nucleic acid; b) amplifying a... Agent:

20120122096 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122097 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122098 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122099 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122100 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122101 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122102 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122103 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:

20120122107 - Homeostatic multidomain protein, and uses for it: The invention relates to the discovery and characterization of mannan binding lectin-associated protein (map44), a new protein that acts in the lectin pathway of complement activation.... Agent: Aarhus Universitet

20120122095 - Materials and methods for the detection of anthrax related toxin genes: Disclosed are methods and kits for identifying a virulent bacteria in a sample, which may include virulent bacteria belonging to the Bacillus genus (e.g., Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis). Typically, the methods include (a) reacting a mixture that includes, in addition to nucleic acid isolated from the sample,... Agent: Eragen Biosciences, Inc.

20120122110 - Method for isolating cells: The present invention relates to a method and kit for the isolation of cells from a sample. The sample is treated with an extraction solution that comprises at least MgCl2 and/or an ionic liquid resulting in the isolation of preferably viable cells.... Agent: Merck Patent Gesellschaft Mit Besdchrankter Haftung

20120122108 - Microfluidic cartridge: The technology described herein generally relates to microfluidic cartridges configured to amplify and detect polynucleotides extracted from multiple biological samples in parallel. The technology includes a microfluidic substrate, comprising: a plurality of sample lanes, wherein each of the plurality of sample lanes comprises a microfluidic network having, in fluid communication... Agent: Handylab, Inc.

20120122106 - Mutation detection assay: A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant copies of the genomic locus that have a point mutation relative to said wild type copies of the... Agent:

20120122109 - Neural progenitor cells derived from embryonic stem cells: The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells... Agent: Es Cell International Pte Ltd.

20120122105 - Real time cleavage assay: A cleavage-based real-time PCR assay method is provided. In general terms, the assay method includes subjecting a reaction mixture comprising a) PCR reagents for amplifying a nucleic acid target, and b) flap cleavage reagents for performing a flap cleavage assay on the amplified nucleic acid target to two sets of... Agent:

20120122104 - Triple-stranded nucleobase structures and uses thereof: The present disclosure relates to compositions and methods of using triplex structures generated by a duplex of a polypurine tract and complementary polypyrimidine tract and a triplex-forming nucleobase polymer that hydrogen bonds to both the purine and pyrimidine bases of the polypurine-polypyrimidine duplex.... Agent: Applera Corporation

20120122111 - Rna sequence-specific mediators of rna interference: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long... Agent:

20120122112 - Antibodies as a cancer diagnostic: Method and kits are provided for the detection and diagnosis of metastatic disease. More particularly, the methods and kits employ compounds that can detect EphA2, a specific epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. In one embodiment the compound is an antibody capable of binding to... Agent: Purdue Research Foundation

20120122113 - Signature of secreted protein isoforms specific to ovarian cancer: The present invention relates to the identification of secreted protein isoforms specific in ovarian cancer and methods for diagnosis or prognosis of ovarian cancer in a subject by detecting the secreted protein isoforms.... Agent: Socpra Sciences Sante Et Humaines S.e.c.

20120122114 - Immunoassay for the detection of procalcitonin: The present invention relates to an in vitro method for the detection of Procalcitonin or a fragment thereof of at least 20 amino acid residues in length in a biological sample derived from a bodily fluid obtained from a subject, comprising the steps of: (i) contacting said sample with at... Agent: B.r.a.h.m.s. Gmbh

20120122115 - Bacterial quorum sensing biosensor: The present invention generally relates to fluorescent resonance energy transfer protein compounds and methods for using such compounds as biosensors. The present invention also relates to one or more nucleic acids for encoding the protein compounds, vectors containing the nucleic acids, cells transformed by the vectors, and methods for making... Agent:

20120122119 - Methods of identifying compounds that bind to a toll-like receptor: The present invention is directed to nucleic acid molecules and polypeptides encoding a dsRNA receptor (dsRNA-R). The dsRNA-R contains a THD, interacts with the MyD88 adapter protein, and may bind to dsRNA. The present invention is also directed to antibodies against dsRNA-R and to methods of modulating an immune response... Agent:

20120122120 - Antibodies against human epo receptor: An antibody binding to human EPO-R, characterized in specifically binding pY461, pY430 or p465 is useful for the determination of activated EPO receptor.... Agent: Hoffmann-la Roche Inc.

20120122121 - Antibodies and immunotoxins that target human glycoprotein nmb: The invention provides high affinity antibodies suitable for forming Immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendroglioma cells, and melanoma cells.... Agent: The Government Of The United States As Represented By The Secretary Of Health

20120122122 - Method of diagnosing cancer: A method of diagnosing cancer is provided. The method comprising determining a level of CEACAM1 on isolated peripheral blood lymphocytes (PBLs) of a subject in need thereof, wherein an upregulation of the level of CEACAM1 above a predetermined threshold is indicative of cancer in said subject.... Agent: Tel Hashomer Medical Research Infrastructure And Services Ltd.

20120122117 - Secreted phospholipase a2 biomarkers for arthritis: The present invention relates to the use of protein expression profiles of sPLA2 isoforms with clinical relevance to osteoarthritis (OA). In particular, the invention provides methods for diagnosing OA or determining risk factors for development of OA based on expression of sPLA2-IIA.... Agent:

20120122116 - Use of lymphocytes to measure anthrax lethal toxin activity: It is disclosed herein that isolated lymphocytes, such as human B-cells and CD4+ T-cell can be used to determine an amount of lymphocyte-associated anthrax lethal toxin activity present. Methods of using isolated lymphocytes to identify anthrax therapeutic agents and to determine the efficacy of a potential anthrax therapeutic are disclosed.... Agent: The Government Of The Usa As Represented By The Secretary Of The Dep. Of Health And Human Service

20120122118 - Monclonal antibodies, hybridomas and methods for use: The present invention provides monoclonal antibodies to TM9SF-proteins and hybridoma cell lines that produce the monoclonal antibodies to TM9SF4. This invention also provides a method for determining the level of TM9SF4-protein in biological fluid samples, tissue samples and in microvesicles such as exosomes, comprising kit for determining the level of... Agent: Hansabiomed Ou

20120122126 - Anti-psk antibody: The object of the present invention is solved by an antibody characterized by recognizing PSK and inhibiting anti-tumor activity of PSK. In particular, the inhibition of anti-tumor activity of PSK is an inhibition of cytotoxic activity or an inhibition of anti-TGF-β1 activity of PSK. A physiologically active PSK can, using... Agent: Kureha Corporation

20120122125 - Anti-t. cruzi antibodies and methods of use: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.... Agent: Abbott Laboratories

20120122127 - Cleavage sensitive antibodies and methods of use thereof: We disclose cleavage-sensitive antibodies with epitopes spanning the scissile bond of the toxins molecular target protein, enabling toxin-associated proteolysis to be measured in a variety of assay formats.... Agent: United States Department Of The Army, As Represented By The Secretary Of The Army

20120122123 - Detection of anthrax pathogenicity factors: One major problem in diagnosis methods presently available for anthrax is that these methods require several days to produce a result. The only existing treatment for anthrax requires administration soon after infection at a time when patients are exhibiting only mild flu-like symptoms. Thus, a patient may be days beyond... Agent: The Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services

20120122124 - New bacteriophage adhesion proteins: The present invention relates to bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides. The invention further relates to nucleic acid molecules comprising a sequence encoding the proteins according to the present invention. In addition, the... Agent:

20120122128 - Immuno-based botulinum toxin serotype a activity assays: The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A... Agent:

20120122129 - Rapid nasal assay kit: The present invention relates to an assay which can be used on nasal secretions. The assay is used to determine the cause of nasal secretions, for example whether the secretions are due to an allergic reaction or a non-allergic reaction.... Agent: Toxcure, LLC

20120122130 - Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same: The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence... Agent: Ikeda Food Research Co., Ltd.

20120122131 - Simultaneous detection of metabolic enzyme activity and metabolite levels: Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) a metabolically indicative enzyme and (ii) a metabolic analyte, with a substrate for the enzyme to produce a reaction admixture, under conditions wherein the enzyme is capable... Agent: Perkinelmer Health Sciences, Inc.

20120122133 - Novel devices for the detection of the presence and/or activity of proteases in biological samples: The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples... Agent:

20120122132 - Protein structural biomarkers to guide targeted chemotherapies: A rapid, infrared spectroscopic method has been developed to assess the efficacy of targeted chemotherapeutics against the structure of the polypeptide target, based on the effect of natural polymorphic sequence variation on the conformation of the protein. This method has an advantage over the current genomics-based screening, as the new... Agent:

20120122134 - Novel peptidase substrates: r

20120122135 - Novel peptidase substrates:

20120122137 - Novel nitroreductase enzymatic substrates: The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or... Agent: Biom&#xe9 Rieux S.a.

20120122136 - Self-immolative probes for enzyme activity detection: In this compound, SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an... Agent: Enzo Life Sciences, Inc., C/o Enzo Biochem, Inc.

20120122142 - Cell deposition system: A system for depositing cells on an analysis plate, the cells being contained in a cell suspension including a fixing agent and the cells, included, for receiving the suspension, a chamber (5) which is positioned above the analysis plate and whose base is open and extends opposite a cell depositing... Agent: Novacyt

20120122138 - Consumable component kit: According to the invention there is provided a consumable component kit for use in a system which utilises a liquid culture of a microbiological material, the kit including: a sealed and aseptic culturing vessel; at least one sealed and aseptic chamber for storing a liquid nutrient medium; a sample of... Agent: Cymtox Limited

20120122145 - Insect-based ex vivo model for testing blood-brain barrier penetration and method for exposing insect brain to chemical compounds: There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different chemical compounds in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the... Agent: Entomopharm Aps

20120122144 - Methods employing insect models for determining intestinal absorption of chemical compounds: There is provided insect screening models to determine gastrointestinal absorption of different chemical compounds in vertebrates, and in particular humans, in order to improve the compound screening procedures/processes in the early drug discovery process. This offers many advantages relative to prior technologies since insect models are more reliable tools for... Agent: Entomopharm Aps

20120122139 - Microfluidic device and hemoglobin measurement method using the same: A microfluidic device and a method for measurement of biomaterials using the same. The microfluidic device includes a microfluidic structure including: a sample chamber which receives and accommodates blood; a reagent chamber which contains a luminescent reactant; a first detection chamber which contains a first material that is positively charged;... Agent: Samsung Electronics Co., Ltd.

20120122146 - Nanoparticle screening methods employing insects with blood brain barrier: There is provided an insect model for determining the penetration of nanoparticles through the BBB. The model is also directed to the use of insects for studying the environmental safety of nanoparticles. The particles are administered into the hemolymf of an insect having a BBB, such as the locust, and... Agent: Entomopham Aps

20120122141 - Point source diffusion cell activity assay apparatus: Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from a point source,... Agent: Neuro Probe Incorporated

20120122143 - Technique for determining maturity of a cell aggregation, image processing program and image processing device using the technique, and method for producing a cell aggregation: An image processing program (GP) is configured to comprise a step (A10) for obtaining time lapse images in which a cell aggregation is imaged over a predetermined time interval by an imaging device, a step (A20) for sequentially calculating a feature value relating to multi-layering of the cell aggregation from... Agent: Nikon Corporation

20120122140 - Ultrasonic method for monitoring cell cultures: A method for monitoring a cell culture, where the method includes measuring pulse-echo ultrasonic waveforms from the cell culture, and analyzing the pulse-echo ultrasonic waveforms to monitor the cell culture.... Agent: Utah State University

20120122148 - Media for the specific detection of gram-negative bacteria resistant to beta-lactam antibiotics: m

20120122147 - Real-time method for the detection of viable micro-organisms: The invention relates to a method for real-time detection of viable microorganisms comprising: a. addition of a cell-permeable, phototautomeric compound to a micro-organism or other living cell; and b. measuring the fluorescent emission of said phototautomeric compound. Preferably the phototautomeric compound is salicylic acid, 2-hydroxy-1-naphtoic acid or 1-hydroxy-2-naphtoic acid. Further,... Agent: Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno

20120122149 - Absorbent bead concentration method that eliminates the need for centrifugation: This invention is a technique that enables the concentration of cells, microorganisms, parasite eggs and cysts using absorbent beads, eliminating the need for centrifugation.... Agent: Salubris, Inc

20120122151 - Cytological or histological binding composition and staining methods: A histological and cytological fixing composition, includes at least alcohol, ethylene glycol, dimethyl sulfoxide, water, and sodium chloride. Also, process for preparing this fixer, as well as to its use in particular in processes for staining cells or cellular structures are described.... Agent: R.a.l. Diagnostics

20120122150 - Stabilization method for biological samples by combination of heating and chemical fixation: The present invention provides methods for stabilizing a biological sample for analysis. The invention more particularly provides methods combining heat treatment and chemical fixation of biological samples in order to maintain protein primary structure and post-translational modifications, such as protein phosphorylations.... Agent: Denator Aktiebolag

20120122152 - Treating biomass to produce materials useful for biofuels: Fermentable sugar useful for the production of biofuels can be produced from biomass by contacting the biomass with a solution containing at least one α-hydroxysulfonic acid. The α-hydroxysulfonic acid can be easily removed from the product and recycled.... Agent: Shell Oil Company

20120122153 - Acid-clevable linkers exhibiting altered rates of acid hydrolysis: An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid... Agent: E. I. Du Pont De Nemours And Company

20120122154 - Method of producing lipidated polypeptides: A method of producing a recombinant lipidated polypeptide in E. coli. The method includes providing an E. coli host cell adapted to express a recombinant lipidated polypeptide; and culturing the E. coli host cell in a minimal medium under conditions that allow expression of the polypeptide in lipidated form.... Agent: National Health Research Institutes

20120122155 - Immortalized avian cell lines and use thereof: The present invention relates to specific immortalized avian cell lines expressing telomerase reverse transcriptase (TERT), and exhibiting distinct biologics production patterns. More particularly, the present invention relates to immortalized avian cell line capable of either amplifying Flaviviridae but not capable of amplifying Vaccinia virus strain Copenhagen (W—COP) nor Modified Vaccinia... Agent: Transgene S.a.

20120122156 - Recombinant protein of fibroblast growth factor having adhesive activity for stem cells and method for culturing stem cells using the same: The present invention relates to a recombinant protein of a fibroblast growth factor (FGF) having an adhesive activity for stem cells and a method for culturing stem cells using the same. More particularly, the present invention relates to a recombinant protein having an adhesive activity for stem cells by fusion... Agent:

20120122157 - Signal peptide for producing a polypeptide: The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to... Agent: Novozymes A/s

20120122158 - Pcr for dna that is resistant to amplification: DNA that is difficult to amplify by conventional PCR is amplified by a modified PCR process that includes a high-temperature, short-term heating step as the last step of each thermal cycle, following the conventional denaturing and annealing/elongation steps.... Agent: Bio-rad Laboratories, Inc.

20120122159 - Pcr-based method of synthesizing a nucleic acid molecule: There is provided a method of synthesizing a nucleic acid molecule and in one aspect, the method comprises assembling a full length template nucleic acid molecule by PCR in a PCR reaction mixture comprising a set of assembly oligonucleotides having a first average melting temperature and a set of outer... Agent: Agency For Science, Technology And Research

20120122160 - Thermal cycler and thermal cycling method: A thermal cycler includes a holder to which a biotip having a longitudinal direction is attached in such a manner that one end portion of the biotip is at a higher level than the other end portion, and that the distance between one end portion of the biotip and the... Agent: Seiko Epson Corporation

20120122161 - Sorting asymmetrically tagged nucleic acids by selective primer extension: The present invention provides methods and compositions for amplifying and sorting adapter tagged nucleic acid fragments using selective primer extension. Immortalized pooled polynucleotide samples and method of producing the same are also provided.... Agent:

20120122162 - Enzymatic hydrolysis of pre-treated biomass: This disclosure relates to a method for performing high solids saccharification comprising by (a) providing a cellulosic biomass; (b) pretreating the cellulosic biomass in a pretreatment process to produce a pretreated cellulosic biomass; (c) adjusting said pretreated cellulosic biomass to a solids concentration of 6% to 35% w/w and a... Agent: Andritz Inc.

20120122163 - Microorganism which produces l-amino acid and method for producing l-amino acid using the same: The present invention relates to a microorganism belonging to the genus Escherichia sp. and a method for producing L-amino acid using the same. The microorganism belonging to the genus Escherichia sp. has a sucrose assimilability and L-amino acid producing ability, which is obtained by introducing a gene encoding a sucrose... Agent: Cj Cheiljedang Corporation

20120122164 - Method and system for processing a biomass for producing biofuels and other products: The present invention provides methods of processing a biomass, e.g., for producing lipid and non-lipid materials, by inducing autolysis of a biomass. The biomass may be generated using any species of microorganism and any available biodegradable substrate, including waste materials. The lipid and non-lipid materials are present in two separate... Agent:

20120122165 - Recombinant microorganism and method for producing aliphatic polyester with the use of the same: This invention provides a recombinant microorganism exhibiting excellent aliphatic polyester productivity and a method for producing an aliphatic polyester with the use of the recombinant microorganism. In this invention, the Megasphaera elsdenii-derived pct gene (and/or the Staphylococcus aureus-derived pct gene) and the Pseudomonas sp. 61-3 strain-derived PHA synthase gene (phaC2... Agent: Toyota Jidosha Kabushiki Kaisha

20120122167 - Method for producing lactic acid: Provided is a method for producing lactic acid, which includes: obtaining D-lactic acid or L-lactic acid by carrying out lactic acid fermentation using a lactic acid-producing microorganism under a pressurized condition that exceeds normal pressure and is capable of maintaining lactic acid production activity of the lactic acid-producing microorganism.... Agent: Mitsui Chemicals, Inc.

20120122166 - Mutant methylglyoxal synthase (mgs) for the production of a biochemical by fermentation: o

20120122168 - Recombinant escherichia coli having enhanced acetyl-coenzyme a synthetase activity for producing glyerol and glycerol-derived products: Recombinant E. coli having enhanced acetyl-CoA synthetase activity and the ability to produce glycerol and glycerol-derived products, such as 3-hydroxypropionic acid, methylglyoxal, 1,2-propanediol, and 1,3-propanediol, are described. The recombinant E. coli comprise a promoter operably linked to a nucleotide sequence encoding a polypeptide having acetyl-CoA synthetase enzyme activity, wherein the... Agent: E. I. Du Pont De Nemours And Company

20120122169 - Mutant yqhd enzyme for the production of a biochemical by fermentation: c

20120122170 - in situ production of furfural in a controlled amount in an alcohol production unit from a lignocellulosic biomass:

20120122171 - Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors: The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce... Agent: Genomatica, Inc.

20120122172 - Method for producing ethanol from xylose using recombinant saccharomyces cerevisiae transformed to eliminate functions of genes involved in tor signal transduction pathway: Disclosed is a method for producing ethanol from zylose using a Saccharomyces cerevisiae strain transformed to eliminate functions of genes involved in TOR signal transduction pathways. The method provides an increase in ethanol yield and production efficiency, as compared to a control group, and enables production of ethanol at higher... Agent: Snu R&db Foundation

20120122173 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing in a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor... Agent: Ineos Bio Limited

20120122174 - Non-sterile fermentation of bioethanol: A range of concentrations exists in which fermentation inhibitors derived from pretreatment of lignocellulosic feed stocks inhibit growth of lactic acid bacteria without affecting fermentive yeast. By optimizing levels of fermentation inhibitors to fall within this range, yeast fermentations of lignocellulosic biomass can be conducted under non-sterile conditions with ethanol... Agent: Inbicon A/s

20120122175 - Method and device for operating a fermentation plant: A method for operating a fermentation plant with at least one digester (1) that is supplied with a substrate (1a). The substrate (1a) is percolated using a percolate (2a) from a percolate container (2) and biogas that is generated via the percolation process in the digester (1) or/and in the... Agent: Kompoferm Gmbh

20120122176 - Cellulase cel5h related reagents and their use in microorganisms: The invention relates to applications of the cellulase Cel5H of Saccharophagus degradans and its homologues, functional fragments and/or variants and engineered forms thereof, in the context of recombinant, more particularly solventogenic microorganisms, more particularly C. acetobutylicum. The invention also characterizes a novel domain of the Cel5H cellulase with a putative... Agent: L'universite De La Mediterranee

20120122177 - Viral infection enhancing peptide: The invention relates to a peptide derived from HIV-1 gp120 which forms insoluble aggregates when introduced into an aqueous solution and its use for enhancing viral infection of cells. In addition, the invention comprises methods for enhancing viral infection of cells, for concentrating a virus and for separating a virus... Agent:

20120122178 - Human aminoacyl-trna synthetase polypeptides useful for the regulation of angiogenesis: The present invention provides an isolated polypeptide comprising residues 94-471 of SEQ ID NO: 10, wherein the isolated polypeptide does not comprise amino acid residues 1-47 of SEQ ID NO: 10. Nucleic acids and expression vectors encoding the peptide also are provided.... Agent: The Scripps Research Institute

20120122180 - Incorporation of type iii polyketide synthases into multidomain proteins of the type i and iii polyketide synthase and fatty acid synthase families: Recombinant fusion proteins in which intermediates are covalently bound to the fusion proteins and transferred between domains of the fusion proteins are provided. The fusion proteins include proteins having type I polyketide or fatty acid synthase domains fused with type III polyketide synthase domains. Methods of making such recombinant fusion... Agent: Salk Institute For Biological Studies

20120122179 - Means for purifying a protein of blood plasma and methods for implementing same: An affinity substrate for the selective binding of a protein of blood plasma includes a solid substrate material on which are immobilized deoxyribonucleic aptamers specifically binding with the plasma protein.... Agent: Lfb Biotechnologies

20120122181 - Method for determining antagonist activity to a cytokinin receptor: The present invention provides a method for analyzing agonist-activity to a cytokinin receptor, which comprises (1) bringing an examinee substance into contact with a transformed cell into which DNA coding the cytokinin receptor is introduced and (2) measuring the existence or the quantity of intracellular signal transduction from the cytokinin... Agent: Sumitomo Chemical Company, Limited

20120122182 - Gaussia luciferase variant for high-throughput screening: Described herein is a variant of wild type Gaussia luciferase that catalyzes glow-type emission kinetics suited for high-throughput functional screening applications. Polypeptides, functional fragments, variants, and nucleic acids that encode the enhanced luciferase are further described. One such polypeptide corresponds to wild type Gaussia luciferase with a substitution mutation of... Agent: The General Hospital Corporation

20120122183 - Flocculation with divalent salt and phosphate: A method of flocculating a bacterial cell, producing a protein of interest, from a fermentation broth, comprising a) diluting the fermentation broth up to 1000% (w/w) with water; b) adding a divalent salt to a concentration in the fermentation broth of more than 10 milli moles per liter diluted fermentation... Agent: Novozymes A/s

20120122184 - Polypeptides of strain bacillus sp. p203: m

20120122185 - Chimeric viruses presenting non-native surface proteins and uses thereof: The present invention provides chimeric negative-stand RNA viruses that allow a subject, e.g., an avian, to be immunized against two infectious agents by using a single chimeric virus of the invention. In particular, the present invention provides chimeric influenza viruses engineered to express and incorporate into their virions a fusion... Agent:

20120122186 - Novel bacteriophage strains for the treatment of bacterial infections, especially drug resistant strains of the genus enterococcus: Novel bacteriophage strains are disclosed and their use in the production of preparations for use in the treatment of bacterial infections, particularly with drug resistant strains of bacteria of the genus Enterococcus, particularly those belonging to the species Enterococcus faecalis.... Agent:

20120122188 - Live organism product: A live organism product wherein the organisms are in a dormant state and are suspended in a liquid carrier which is sufficiently devoid of moisture so that the organisms will remain in a dormant state for several months. The carrier is comprised of oil. The carrier may also include an... Agent:

20120122187 - Method for increasing the concentration of colonies of micro organisms in a process for removing contaminants by anaerobic digestion: The present invention refers to a process to increase the concentration of micro organisms' colonies which are formed on the surface of Gramineas bambusoideae in a batch and/or continuous flow process which utilizes biomass as a filtration means in order to remove nitrates as well as organic and inorganic impurities... Agent: Mercosul Comercial Ltda.

20120122189 - Lactobacillus mutant: The present invention discloses a Lactobacillus mutant, which is Lactobacillus paracasei subsp. paracasei PAN 101 and deposited in Agricultural Research Culture Collection (NRRL) in Nov. 13, 2009, and the accession number is NRRL B-50335; Lactobacillus paracasei subsp. paracasei PAN 101 can produce L(+)-lactate, and the production of L(+)-lactate in Lactobacillus... Agent:

20120122190 - Red mold mutant that can increase the production of monascus metabolites: The present invention discloses a Red mold mutant that can increase the production of monascus metabolites, wherein the Red mold mutant is Monascus purpureus NTU 568 and deposited in Agricultural Research Culture Collection (NRRL) in Nov. 13, 2009, and the accession number is NRRL 50338. The disclosed Monascus purpureus NTU... Agent:

20120122191 - Methods for producing secreted polypeptides: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a nucleic acid construct comprising a first nucleotide sequence encoding a signal peptide operably linked to a... Agent: Novozymes, Inc.

20120122192 - Edible oils and food compositions from heterotrophic microorganisms: The invention provides methods of manufacturing oils and oil-based products such as transportation fuels, industrial chemicals, edible oils, lubricants and plastics using sugar cane, sugar cane juice, corn steep liquor, corn starch or depolymerized cellulosic material as a feedstock for bioproduction processes. The disclosed processes utilize oil-bearing microbes as a... Agent: Solazyme, Inc.

20120122193 - Engineered co2 fixing microorganisms producing carbon-based products of interest: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the... Agent: Joule Unlimited Technologies, Inc.

20120122194 - Method for the total gasification of garbage or waste: A method for treating garbage or waste in which the garbage or refuse is subjected to at least one compression step (14) under conditions enabling the separation thereof into a putrescible fraction (15) in the form of a moist pulp, and into a dry fraction (16) with a relative moisture... Agent: D.m.s.

20120122195 - Process for co2 capture using micro-particles comprising biocatalysts: A process for capturing CO2 includes contacting a CO2-containing gas with an absorption mixture optionally within a packed reactor is provided. The absorption mixture includes a liquid solution and micro-particles. The micro-particles include a support material and biocatalyst supported by the support material and are sized and provided in a... Agent:

20120122196 - Methods and products for biomass digestion: Provided herein are methods and products for biomass digestion, which includes the production of biogas, U.S. Environmental Protection Agency classified Class A Biosolids, and pathogen reduced organic liquid fertilizer. Through the digestion of waste materials using sequential phases in an efficient digestion process, enhanced biomass conversion efficiency and improved output... Agent: Landmark Structures I, Lp

20120122197 - Inkjet reagent deposition for biosensor manufacturing: A technique for producing a biosensor includes inkjet printing a reagent onto electrodes of the biosensor. The ink has been specially formulated to allow the reagent to be printed using inkjet printing while at the same time produce commercially viable biosensor. The inkjet printing of the reagent allows for different... Agent:

20120122198 - Biosensor manufacturing method: A biosensor having a first conductive component is described, wherein the first conductive component includes at least one boundary formed by a first processing technique and at least one boundary formed by a second processing technique not the same as the first processing technique. The biosensor can also have a... Agent: Nipro Diagnostics, Inc.

20120122199 - Photobioreactor for the growth and development of photosynthetic and heterotrophic microorganisms: A photobioreactor, especially for the growth and development of photosynthetic microorganism such as microalgae or cyanobacteria. The photobioreactor includes at least one reflector (101) placed on one side of the photobioreactor and tubes arranged in a plurality of layers following one after another along a direction (N) normal to the... Agent:

20120122200 - Biogas plant service device: A biogas plant service device and an associated biogas plant with a service shaft for biogas plants includes a fermentation tank with a tank wall, a fermentation tank interior and a tank cover covering the fermentation tank interior. The service shaft has a service opening to carry out the assembly,... Agent:

20120122201 - Gas flow rate and liquid level monitoring apparatus: An incubator (10) comprising an incubator housing (14), at least one sealable incubation chamber (16) in the housing (14), means for controlling temperature, humidity and gas composition within the incubation chamber (16), a liquid container (26), and a window (24) for observing the gas flow rate and liquid level of... Agent: Planer PLC

20120122202 - Flask for preparing a cytological suspension based on a fixing solution: A system for preparing a cytological suspension is based on a fixing solution. The system containing a cytological sample-taking brush and a flask having an opening for receiving the cytological sample-taking brush are detachably fastened to a handle including a brush-receiving filter basket that is at least partially immersed in... Agent: Maclip

20120122204 - Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna: The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection... Agent:

20120122203 - Methods and kits to generate mirna- and small rna-expressing vectors, and its application to develop lentiviral expression libraries: The invention relates to novel expression systems for microRNAs (miRNAs) based on the expression of the sense and antisense strand from convergent promoters. The invention also provides a method for the direct cloning of small RNAs present in an RNA preparation by the direct ligation of the small RNAs present... Agent: Newbiotechnic, S.a.

20120122205 - Modular dna-binding domains and methods of use: The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specifically recognized by a polypeptide... Agent:

20120122206 - Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity: The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fragments, or a fusion protein that includes a region equivalent to the Fc region of an... Agent: Roche Glycart Ag

20120122207 - Method for expanding monocytes: The invention relates to an ex vivo method for expanding monocytes, macrophages or dendritic cells, which method comprises inhibiting the expression or the activity of MafB and c-Maf in monocytes, macrophages or dendritic cells; and expanding the cells in the presence of at least one cytokine or an agonist of... Agent: Inserm (institute National De La Sante Et De Recherche Medicale)

20120122210 - Carrier peptide fragment and use thereof: A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of... Agent: Toagosei Co. Ltd.

20120122208 - Tubular bioreactor system for use in bone and cartilage tissue engineering: A bioreactor system includes a growth chamber having an inlet, an outlet, and defining a cavity, a media reservoir is in fluid communication with the inlet, and a pump configured to perfuse a media from the reservoir into the inlet and through the growth chamber. A plurality of discrete scaffold... Agent: University Of Maryland, College Park

20120122209 - Undifferentiated stem cell culture systems: The present disclosure provides methods for maintaining and propagating undifferentiated pluripotent stem cells (SC) in suspension. The methods comprise culturing such SC in a non-adherent culture dish under conditions comprising a basic serum free medium and one or more of a basic medium, a serum replacement, an extra cellular matrix... Agent: Hadasit Medical Research Services & Development Limited

20120122211 - Generation of neural stem cells from undifferentiated human embryonic stem cells: The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention... Agent: Es Cell International Pte Ltd.

20120122213 - Method for culturing stem cells: In the field of biological technology, a stem cell culture method is provided. The method includes preparing an amniotic epithelial cell feeder layer that is not treated to lose the division ability; and seeding the stem cells onto the amniotic epithelial cell feeder layer, and culturing in a culture medium.... Agent:

20120122212 - Tgf-beta pathway inhibitors for enhancement of cellular reprogramming of human cells: The present disclosure provides methods and compositions to enhance reprogramming in human cells. In some cases, the method includes contacting human cells with an inhibitor of the TGFβ pathway, for example a TGFβ receptor (TGFβR) inhibitor in combination with one or more induction factors.... Agent:

20120122214 - Method for producing cell medicine: It is an object of the present invention to provide a method for producing a cell medicine that is effective for diseases while causing a low risk to these diseases. The present invention provides a method for producing a phagocyte that expresses a foreign protein, which comprises: a step of... Agent: National University Corporation Kumamoto University

20120122215 - Placental stem cell populations: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.... Agent:

20120122217 - Methods and compositions for reducing target gene expression using cocktails of sirnas or constructs expressing sirnas: The present invention concerns methods and compositions involving the production or generation of siRNA mixtures or pools capable of triggering RNA-mediated interference (RNAi) in a cell. Compositions of the invention include kits that include reagents for producing or generating siRNA pools. The present invention further concerns methods using polypeptides with... Agent: Applied Biosystems, LLC

20120122216 - Oligomeric compounds and compositions for use in modulation of small non-coding rnas: Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment... Agent: Regulus Therapeutics, Inc.

20120122218 - Harnessing cell dynamics to engineer materials: The invention features synthetic materials and methods for inducing cell behavior. Matrix materials induce cell differentiation and cell manipulation based on mechanical and physical characteristics of the materials rather than chemical characteristics.... Agent: President And Fellows Of Harvard College

20120122219 - Porous composite biomaterials and production method of the same: The invention discloses a porous composite biomaterial comprising of poly(γ-glutamic acid)-g-chondroitin sulfate (γ-PGA-g-CS) copolymer and poly(ε-caprolactone). The composite biomaterial provides a three-dimensional microenviroment for using as a scaffold for tissue engineering and for supporting the attachment and proliferation of cells. The invention also discloses a method of producing a porous... Agent:

20120122220 - Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells: A method of preparing a stromal cell conditioned medium useful in expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) establishing a stromal cell culture in a stationary phase plug-flow bioreactor under continuous flow on a substrate in the... Agent: Pluristem Ltd

20120122221 - Culture medium and hydrophilic composite thereof: A hydrophilic composite includes a carbon nanotube structure and a protein layer. The carbon nanotube structure has at least one carbon nanotube film. The protein layer covers one surface of the carbon nanotube structure, and is coupled to the at least one carbon nanotube film. The carbon nanotube structure is... Agent: Tsinghua University

20120122222 - Nanotopographic compositions and methods for cellular organization in tissue engineered structures: The present invention relates to tissue engineered compositions and methods comprising nanotopographic surface topography (“nanotopography”) for use in modulating the organization and/or function of multiple cell types.... Agent: The Charles Stark Draper Laboratory

20120122223 - Mutated protoporphyrinogen ix oxidase (ppx) genes: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.... Agent: Cibus US LLC

20120122224 - Device for performing photochemical processes: Device for carrying out photochemical processes on a microscale and use of the device for photochemical reactions and culturing photosynthesizing cells and/or microorganisms.... Agent: Ehrfeld Mikrotechnik Bts Gmbh

20120122225 - Carrier peptide fragment and use thereof: The method for transferring a foreign substance provided by the present invention includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence WRRQARFK (SEQ ID NO. 1) or any amino acid sequence formed by the substitution,... Agent: Toagosei Co. Ltd.

  
05/10/2012 > 112 patent applications in 60 patent subcategories. archived by USPTO category

20120115124 - Irradiation of red blood cells and anaerobic storage: A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon... Agent:

20120115125 - Assay for detecting and quantifying hiv-1: Method of detecting HIV-1 nucleic acids using nucleic acid amplification and a molecular torch hybridization probe. The invented method is characterized by high levels of precision in the quantitation of HIV-1 targets at low copy numbers, and by accurate detection of different HIV-1 subtypes, including M group and O group... Agent: Gen-probe Incorporated

20120115126 - Compositions and methods for rapid, real-time detection of influenza a virus (h1n1) swine 2009: Disclosed are oligonucleotide amplification primers and detection probes specific for the amplification and detection of pathogenic organisms, including for example, specific Influenza A H1N1 viral isolates. Also disclosed is a biological organism identification kit including the disclosed nucleic acid probes and primers, as well as thermal cycling reagents that is... Agent: Longhorn Vaccines & Diagnostics, LLC

20120115129 - Enzyme substrate comprising a functional dye and associated technology and methods: Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least... Agent: Biotium, Inc.

20120115130 - Method for detecting target cell: A target cell detection method includes performing a test measurement on a dispersion to obtain a measurement result 1, the test measurement being an optical or electromagnetic measurement, and the dispersion including labeled particles and target cells, the labeled particles being particles on each of which a substance that specifically... Agent: Jsr Corporation

20120115127 - Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity: The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes... Agent: The Regents Of The University Of California

20120115128 - Selective protein labeling: The present invention is related to methods of detecting protein-protein interactions in living cells, as well as detecting the formation and/or inhibition of protein-protein interactions in cells.... Agent: The Board Of Trustees Of The University Of Illinois

20120115133 - Cyanine dyes: The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.... Agent: Biosearch Technologies Inc.

20120115144 - Detection of extracellular tumor-associated nucleic acid in blood plasma or serum: This invention relates to detection of specific extracellular DNA in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease. Specifically, the invention relates to detection tumor-associated DNA, and to those methods of detecting and monitoring tumor-associated DNA found in the plasma or serum... Agent: The Penn State Research Foundation

20120115142 - Endpoint taqman methods for determining zygosity of cotton comprising cry1ac event 3006-210-23: A method for zygosity analysis of the cotton Cry1Ac event 3006-210-23 is provided. The method provides 3006-210-23 event-specific and cotton-genome-specific primers and TaqMan probe combinations for use in an endpoint biplex TaqMan PCR assay capable of determining event zygosity and for assisting in event introgression and breeding.... Agent: Dow Agrosciences LLC

20120115141 - Endpoint taqman methods for determining zygosity of cotton comprising cry1f event 281-24-236: A method for zygosity analysis of the cotton Cry1F event 281-24-236 is provided. The method provides 281-24-236 event-specific and cotton endogenous reference gene-specific primers and TaqMan probe combinations for use in an endpoint biplex TaqMan PCR assay capable of determining event zygosity and for assisting in event introgression and breeding.... Agent: Dow Agrosciences LLC

20120115131 - Genetic lesion associated with cancer: The invention comprises methods for identifying mutations within the 3′ UTRs of genes that lead to increased risk or probability of developing cancer.... Agent: Yale University

20120115132 - Identification of centromere sequences using centromere associated proteins and uses thereof: The present invention is directed to methods of centromere discovery using centromere-associated proteins in a variety of experimental formats. The methods of the invention can be used on any organism, and include using Cal1, Cbf1, Cbf3, Cbf5, CenH3 (Cenp-A), Cenp-B, Cenp-C, Cenp-D, Cenp-E, Cenp-F, Cenp-G, Cenp-H, Cenp-I, Cenp-K, Cenp-L, Cenp-M,... Agent: Chromatin, Inc.

20120115135 - Method for detection of active periodontal disease at the local tooth site: A method for site-specific detection and early diagnosis of periodontal disease using periodontal pocket fluid biomarkers is disclosed.... Agent: University Of Medicine And Dentistry Of New Jersey

20120115139 - Method for evaluating cancer: Provided is a cancer evaluation method using a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject. At least one miRNA selected from hsa-miR-92 and hsa-miR-494 is used as the novel cancer marker in cancer evaluation. The... Agent: Nec Corporation

20120115138 - Method for in vitro diagnosing a complex disease: The present invention relates to a method and kit for in vitro diagnosing a complex disease such as cancer, in particular, acute myeloid leukemia (AML), colon cancer, kidney cancer, prostate cancer; transient ischemic attack (TIA), ischemia, in particular stroke, hypoxia, hypoxic-ischemic encephalopathy, perinatal brain damage, hypoxic-ischemic encephalopathy of neotatals asphyxia;... Agent: Biocrates Life Sciences Ag

20120115151 - Method for testing a subject thought to be predisposed to having metastatic cancer using delta133p53beta: The present invention concerns a method of testing a subject thought to be predisposed to having a metastatic cancer which comprises: analyzing a biological sample from said subject for detecting the presence of a p53 isoform selected from the group consisting of Δ133p53, Δ133p53γ and Δ133p53β, the presence of said... Agent: Centre National De La Recherche Scientifique (cnrs)

20120115146 - Method of analyzing genetically abnormal cells: The present invention relates to a method for analyzing genetically abnormal cells including (a) preparing a cell sample containing eukaryotic cells, (b) conducting an antigen-antibody reaction to cells contained in the cell sample using antibodies which specifically bind to a molecule existing on the cell surface of eukaryotic cells after... Agent: Olympus Corporation

20120115134 - Methods for diagnosis and prognosis of cancer: We have discovered a protein in humans, herein referred to as collagen like gene (CLG) product (SEQ ID NOS: 12 and 13), that is expressed in human prostate cancer and breast cancer cell lines but not in normal adult, placenta, lung, liver, skeletal muscle, kidney or pancreas tissues. We have... Agent: Children's Medical Center Corporation

20120115137 - Methods of predicting osteoarthritis: The present invention relates generally to methods for predicting progression, initiation and susceptibility of osteoarthritis in human subjects using their genotype test results.... Agent:

20120115150 - Mirna biomarkers for the diagnosis of duchenne muscular dystrophy, its progression and for monitoring therapeutic interventions: The invention refers to diagnosis and therapy of muscle degenerative disorders, as Duchenne Muscular Dystrophy (DMD) by means of a class of specific miRNAs.... Agent: Universit&#xc0 Degli Studi Di Roma "la Sapienza"

20120115140 - Molecular diagnosis of fragile x syndrome associated with fmr1 gene: The present invention includes a rapid, selective, and accurate method of diagnosing a human subject with a triplet repeat genetic disorder of the FMR1 gene that leads to fragile X syndrome. The present invention also includes a rapid, selective, and accurate method of diagnosing a human subject at risk for... Agent: Yale University

20120115147 - Neuropsychiatric test reports: Methods and reports for presenting genetic information that is patient-specific and relevant to treatment of neuropsychiatric disorders, including treatment resistant depression. The methods and reports described include genotype information for each of six specific genetic loci and allow patient-specific therapy for the effective treatment of treatment resistant disorders (TRD).... Agent:

20120115136 - Pna diagnostic use: The present invention pertains to certain nucleic acid analogs and related kits that are useful for the capture, recognition, detection, identification, or quantification of certain chemical or biological entities.... Agent: Pna Patent Owners (a/k/a Cig)

20120115148 - Reagents and methods for detecting neisseria gonorrhoeae: This invention provides compositions and methods for detecting Neisseria gonorrhoeae in a sample. This invention also provides related reaction mixtures, kits, systems, and computers.... Agent: Roche Molecular Systems, Inc.

20120115152 - Screening method: The present invention relates to clinical diagnosis of Alzheimer's disease or early-stage Alzheimer's disease in the live patient. In particular, the invention provides a screening method which can be used to assist with diagnosis of Alzheimer's disease in live human subjects, or to identify human subjects with a predisposition to... Agent:

20120115149 - Serotonin transporter gene and treatment of alcoholism: The gene (SLC6A4) responsible for encoding the serotonin transporter (SERT) has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the... Agent: University Of Virginia Patent Foundation

20120115145 - Strand displacement activity of modified polymerases and uses thereof: The present invention is directed to the use of the strand displacement activity of a modified polymerase. The present invention is more specifically directed to a modified Taq DNA polymerase, which exhibits strand displacement activity, whereas the native polymerase does not possess the strand displacement activity.... Agent: Oxitec Ltd

20120115143 - Universal probe assay methods: Reagents and methods are provided for detecting the presence of a target polynucleotide in a sample are disclosed. In one aspect, a method for producing a labeled amplification product by amplifying a target nucleic acid sequence to produce an amplification product comprising the target sequence, a first probe-binding sequence 5′... Agent: Fluidigm Corporation

20120115153 - Marker for prognosis of liver cancer: The present invention relates to a marker for the prognosis of liver cancer; a composition for estimating the prognosis of liver cancer, which contains a substance for detecting a change in the expression level of the prognostic marker for liver cancer; a kit for estimating the prognosis of liver cancer,... Agent: Cbs Bioscience, Co., Ltd.

20120115155 - Method for amplifying nucleic acid: Disclosed is a nucleic acid amplification method which is based on a new principle and enables to amplify a nucleic acid having a specific nucleotide sequence in a simple manner, within a short time and with efficiency. The nucleic acid amplification method comprises the steps of: (a) obtaining a linear... Agent: Toyo Seikan Kaisha Ltd

20120115154 - Reference markers for biological samples: DNA oligomers comprising sequences that are absent from the genome of one or more organisms of interest are used as reference markers (RMs). The RMs are added to biological samples to “tag” and subsequently identify the samples as authentic and to distinguish tagged samples from samples obtained without said markers,... Agent:

20120115157 - Methods for screening for antibiotic compounds: The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.... Agent: Trustees Of Dartmouth College

20120115156 - Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use: Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was... Agent: Institut Pasteur And Centre Nationale De La Recherche Scientifique

20120115158 - Method to determine embryo and oocyte quality based on ceramidase: The present invention relates to a method of predicting the likelihood of embryo or oocyte survival. This method involves providing a sample of an embryo, an oocyte, or surrounding liquid or cells, and screening the sample for ceramidase expression or activity. The ceramidase expression or activity obtained through said screening... Agent: Mount Sinai School Of Medicine

20120115159 - Blood analyzer and blood analyzing method: The present invention provides a blood analyzer and a blood analyzing method capable of obtaining information regarding B lymphocytes and T lymphocytes without using a fluorescence-labeled antibody. The blood analyzer of the present invention includes a blood specimen supplying portion, a sample preparation portion that prepares a measurement sample without... Agent: Sysmex Corporation

20120115162 - Anti-fatty acid amide hydrolase-2 antibodies and uses thereof: Antibodies that specifically bind to fatty acid amide hydrolases and methods of using the antibodies are provided herein.... Agent: Infinity Pharmaceuticals, Inc.

20120115161 - Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growth: Serum-containing and serum-free immunoglobulin inhibitors of steroid hormone responsive cancer cell growth are disclosed, along with their methods of production. Also disclosed are defined cell culture media, assay protocols, and model systems using the inhibitors for demonstrating steroid hormone growth effects of natural and synthetic substances, and other cell culture... Agent:

20120115164 - Mammalian cytokines; related reagents: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering Corporation

20120115163 - Marked peptides and use thereof for assaying circulating irap: A method for the assay of the circulating extracellular portion of the IRAP protein (“insulin responsive aminopeptidase”) includes at least one stage of quantitative assay of the purified, secreted, extracellular portion of IRAP, via at least one labelled peptide, the labelled peptide interacting specifically with the extracellular portion of IRAP.... Agent: Universite Joseph Fourier

20120115160 - Method for detecting invasive microvescles derived from tumor cells: The present application relates to the isolation and analysis of populations of microvesicles, such as populations of microvesicles that are shed by tumor cells and contain the protein ARF6. Invasive microvesicles from tumor cells contain a variety of specific proteins, including ARF6.... Agent:

20120115167 - Method and apparatus for isolating a target bioentity from a biological sample: A method for isolating a target bioentity from a biological sample, comprises contacting the biological sample with a magnetically-labelled ligand having selective binding affinity for the target bioentity, or for a determinant on the target bioentity, to form a target bioentity/labelled ligand complex, locating a separation module having a defined... Agent: Clinical Genomics Pty. Ltd.

20120115165 - Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma: Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.... Agent: University Of Miami

20120115166 - Diagnostic methods for the detection of risk of neurodevelopmental disorders: The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD,... Agent: The Regents Of The University Of California

20120115168 - Bioassay and peptides for use therein: The invention provides a bioassay for detection of Mycobacterium tuberculosis infection comprising artificially modified peptide subsequences of the T-cell epitope from M. tuberculosis Ag85B. Particularly preferred peptides have the form: SGGNNSPAX (SEQ ID 26), where X is Methionine (SEQ ID 18), Leucine (SEQ ID 17), Alanine (SEQ ID 15) or... Agent: Rapid Biosensor Systems Limited

20120115173 - Biomarkers for motor neuron disease: The invention provides methods of determining a diagnosis or prognosis of motor neuron disease in a mammal comprising determining the expression level of one or more proteins or polypeptides of the renin-angiotensin system in a sample taken from a subject. Similarly, aberrant post-translational modification of the proteins or polypeptides as... Agent: University Of Pittsburgh - Of The Commonwealth System Of Higher Education

20120115169 - Hydroxycholesterol immunoassay: Provided is a derivative of 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24S-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol,... Agent: Enzo Life Sciences, Inc. C/o Enzo Biochem, Inc.

20120115171 - Method for diagnosing thrombophilia: The invention relates to a method for diagnosing thrombophilia in a subject suffering from HIV or from a systemic auto-immune disease, said method comprising determining in a blood sample obtained from said subject the level of free Protein S having Activated Protein C (APC) cofactor activity and the level of... Agent: Centre National De La Recherche Scientifique-cnrs

20120115172 - Pten/akt methods and compositions relating to bmp: The present invention relates to a purified molecules, including antibodies, that bind specifically to murine β-catenin phosphorylated at amino acid position Serine552 and to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are... Agent:

20120115170 - Serum mg53 as a diagnostic marker for tissue injury: Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a muscle-related disease or disorder. In addition, the invention relates to targeting the native MG53 found in the blood... Agent: Trimedicine, Inc.

20120115174 - Urinary trypsin inhibitors as diagnostic aid for interstitial cystitis: A method aiding the diagnosis of interstitial cystitis involving the combination of an infection marker and an inflammation marker. More specifically, the method includes correlating the presence of urinary trypsin inhibitors in urine with the absence of traditional infection markers in urine to aid in the diagnosis of interstitial cystitis.... Agent: Siemens Healthcare Diagnostics Inc.

20120115175 - Methods for diagnosing elevated right or left ventricular filling pressure: The present invention features a method of diagnosing elevated left or right ventricular filling pressure and cardiovascular dysfunction in a subject by detecting increased levels of sEng in a biological sample from the subject.... Agent: Tufts Medical Center, Inc.

20120115176 - Method for detecting compounds modulating dimers of vft domain membrane proteins: e

20120115177 - Compositions and methods for diagnosis of shock: Methods and kits for diagnosis and staging of shock, and especially non-septic shock are presented in which protease activities and/or volatile compounds are measured from a biological sample to so identify and/or stage shock.... Agent: Anazyme, LLC

20120115179 - Arrangement, substrate and method for preparing a cell sample: A flexible, thin, elongated band is used as a substrate. Similarly to a magnetic tape, the band is unwound from a feed reel and is transported past an outlet opening of a receptacle containing the cells such that the cells are poured onto the band. Subsequently, the band containing the... Agent: Siemens Aktiengesellschaft

20120115178 - Method of diagnosing gastric cancer by using human neutrophil peptide 1-3: Human neutrophil peptide (HNP) 1-3, used as diagnostic and therapeutic molecular probes, are found in clinical tissues of gastric cancer patients. In the analytical process according to the present disclosure, pairs of gastric cancer tissues are used to seek the putative biomarkers by proteomic strategy based on matrix assisted laser... Agent: Atomic Energy Council-institute Of Nuclear Energy Research

20120115180 - Use of animal cells for screening probiotic bacteria strains: The present invention relates to an in vitro and/or ex vivo method of screening probiotic bacterial strains. The present invention also relates to a method of assessing quality of probiotic culture. In addition, the present invention relates to use of animal cells in screening of a probiotic strain. The present... Agent: Suomen Punainen Risti Veripalvelu

20120115183 - Detector arrangement for blood culture bottles with colorimetric sensors: A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference... Agent: Biomerieux, Inc.

20120115182 - Mass spectrometric diagnosis of septicemia: The invention mainly relates to the mass spectrometric identification of pathogens in blood cultures from blood-stream infections (septicemia). The invention provides a method with which microbial pathogens can be separated in purified form from blood after a relatively brief cultivation in a blood culture flask, without any interfering human proteins... Agent:

20120115184 - Method for the detection of mastitis and milk quality and mastitis sensor: A mastitis sensor and a method for detection of mastitis and determination of milk quality in real time (on-line). Methods and apparatuses for the rapid non-invasive determination of the concentration of dissolved molecular oxygen in milked milk are disclosed. Mastitis sensors are disclosed that include a fiberoptic, amperometric or potentiometric... Agent: University Of Tarty

20120115181 - Systems and methods for cerebrospinal fluid collection: A test tube insert includes a flange having a width greater than a width of a mouth of a larger test tube into which the insert is to be inserted. The flange defines a first central opening. An annulus extends integrally downward from the flange. The annulus includes a fenestrated... Agent: King Saud University

20120115185 - device and method for recovering biogas: A device for recovering biogas, comprising at least one fermenter (13) and a percolate tank (10) for collecting the percolate removed from the fermenter or fermenters (13). The percolate tank (10) has a percolate inlet (10c) that can be connected to an outlet of the fermenter or fermenters (13) and... Agent:

20120115186 - Fermentative production of ethanol from glucose, galactose and arabinose employing a recombinant yeast strain: d

20120115187 - Production of recombinant proteins utilizing non-antibiotic selection methods and the incorporation of non-natural amino acids therein: Provided herein are methods and compositions for expression of a nucleic acid construct comprising nucleic acids encoding a) a recombinant polypeptide, and b) a prototrophy-restoring enzyme in a host cell that is auxotrophic for at least one metabolite. In various embodiments, the host cell is auxotrophic for a nitrogenous base... Agent:

20120115188 - Chimeric dna polymerases: The present invention provides, among other things, chimeric DNA polymerases containing heterologous domains having sequences derived from at least two DNA polymerases that have at least one distinct functional characteristics (e.g., elongation rate, processivity, error rate or fidelity, salt tolerance or resistance) and methods of making and using the same.... Agent: Kapa Biosystems

20120115190 - Air cooling systems and methods for microfluidic devices: Systems and methods for air cooling a microfluidic device using confinement channels to isolate cooling air from exposed liquids are disclosed. The systems and methods may also thermally condition the cooling airflow for improved robustness of the microfluidic device. In one embodiment, the air cooling system includes a split-level cooling... Agent: Canon U.s. Life Sciences, Inc.

20120115189 - Microfluidic and nanofluidic devices, systems, and applications: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves... Agent: Integenx, Inc.

20120115191 - Production of fructo-oligosaccharide and derivatives by use of aspergillus spp: There is provided a new strain, that is Aspergillus fumigatus, MTCC 5453, and its use in the production of fructo-oligosaccharide. The invention also provides an efficient, rapid and method for increased production of fructo-oligosaccharide by using the strain Aspergillus fumigatus MTCC 5453.... Agent: Godavari Biorefineries Ltd.

20120115192 - Method for production of fermentable sugars from biomass: A process for production of fermentable sugars from biomass using multi-enzyme multi-step system is provided herein. The process disclosed in the present invention provides high yielded sugars in less time period. The multi-enzyme system disclosed in the present invention converts celluloses, hemicelluloses and/or mixture thereof to fermentable sugar with higher... Agent:

20120115193 - Transformation of glycerol and cellulosic materials into high energy fuels: The present invention includes a system and method for making a biofuel comprising: providing a nitrogen-limiting, minimal growth media comprising glycerol, sugars generated from cellulosic biomass or both, under conditions in which an oleaginous microbe converts the growth media into at least one of triacylglycerol, neutral lipids, fatty acids, long-chain... Agent: The Texas A&m University System

20120115194 - Microorganisms for the production of adipic acid and other compounds: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or... Agent: Genomatica, Inc.

20120115195 - Product of fatty acid esters from biomass polymers: The invention provides consolidated bioprocessing methods and host cells. The host cells are capable of directly converting biomass polymers or sunlight into biodiesel equivalents and other fatty acid derivatives. In particular, the invention provides a method for producing biodiesel equivalents and other fatty acid derivatives from a biomass polymer including... Agent: The Regents Of The University Of California

20120115196 - Coryneform bacterium transformant and process for producing isobutanol using the same: e

20120115197 - Ketol-acid reductoisomerase using nadh: Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.... Agent: E. I. Du Pont De Nemours And Company

20120115198 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from anaerobic fermentation of a gaseous substrate containing at least one reducing gas in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This... Agent: Ineos Bio Limited

20120115200 - Continuous process for the production of ethanol from lignocellulosic biomass: A continuous process for the recovery of ethanol from hemicellulose and cellulose from lignocellulosic biomass. Yield of fermentable sugars can be maximized by continuous operation of the pre-treatment system and careful selection of pretreatment conditions including the addition of only small amounts of dilute mineral acid and low pressure. With... Agent: Greenfield Ethanol Inc.

20120115199 - Enzymatic hydrolysis of pretreated lignocellulose-containing material with basidiomycota mycelia and yeast cells: A method for producing a fermentation product from a lignocellulose-containing material comprises pre-treating the lignocellulose-containing material; introducing treated basidiomycota mycelia and/or yeast cells to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to an effective amount of hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation... Agent: Novozymes North America, Inc.

20120115201 - Methods and systems for producing biomass and/or biotic methane using an industrial waste stream: Systems and methods for capture and sequestration of CO2, SOx, NOx, and/or other compounds present in industrial waste streams and use of the captured waste as a nutrient source to support a microbial population. The microbial population can use the nutrients from the industrial waste stream and an energy source... Agent:

20120115202 - Photocatalytic hydrogen production in cyanobacteria: A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed.... Agent: Ramot At Tel-aviv University Ltd.

20120115203 - Method for producing 4-hydroxy-l-isoleucine: A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.... Agent:

20120115204 - Virus filtration of liquid factor vii compositions: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).... Agent: Novo Nordisk Healthcare A/g

20120115205 - Botulinum neurotoxin serotype b activatable botulinum neurotoxin serotype bs: The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located in the di-chain loop region; and method of producing modified Clostridial toxins comprising Clostridial toxin substrate... Agent: Allergan, Inc.

20120115206 - Non-tumorigenic mdck cell line for propagating viruses: The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g., viruses). More specifically, the cell lines of the present invention are useful for... Agent: Medlmmune Way

20120115207 - Enhanced production of papillomavirus-like particles with a modified baculovirus expression system: The present invention is concerned with the provision of a method for manufacturing papillomavirus like particles (PV-VLP), comprising the steps of a) culturing a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises at least one polynucleotide encoding a PV L1 polypeptide, and b)... Agent: Deutsches Krebsforschungszentrum

20120115208 - Modular method for rapid assembly of dna: The invention is directed to methods, kits and compositions using specially designed nucleic acid components for efficient assembly of a DNA construct. The method involves a) incubating a support with a first form of nucleic acid components under conditions to form support-bound nucleic acid component complexes; b) removing unbound first... Agent: The Governors Of The University Of Alberta

20120115209 - Method for culturing microorganisms, bioreactor for implementing same and method for producing such a bioreactor: The present invention thus aims to propose a bioreactor which has an improved yield (concentration, productivity), which is capable of culturing microorganisms sensitive to mechanical stresses, and which is energy-saving. The subject matter of the invention is a method for culturing microorganisms in suspension in a culture medium, in which... Agent:

20120115210 - Outdoor cultivator for photosynthetic microorganisms: A novel waterborne cultivator, which provides the benefits of known systems for culture of photosynthetic micro-organisms in a novel configuration, incorporating a simplified, two-phase rotary mixing and gas injection system, the two phases being liquid and gas (CO2). The mixing system provides optimum growth conditions through increased turbulent vertical mixing... Agent: Element Cleantech Inc.

20120115211 - Apparatus for testing the quality of a fluid sample: Apparatus for testing the quality of a fluid sample comprising a body defining an interior space including a primary chamber and one or more secondary chambers, the apparatus having a first configuration in which it is arranged to hold at least some of the fluid sample in the primary chamber... Agent: The University Of Bristol

20120115212 - Assay tube: A non-instrumented biochemical assay device, such as a device for the processing of clinical specimens for molecular diagnostic applications. In one embodiment, an assay device comprises a lid which covers a reagent tube, which is disposed on a base. The platform utilizes chemical heating and optional temperature modulation by phase... Agent:

20120115214 - Portable high gain fluorescence detection system: An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays... Agent: Micronics, Inc.

20120115213 - Systems for bioagent identification: The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis... Agent: Ibis Biosciences, Inc.

20120115216 - Container for testing for micro-organisms: A multi-compartment resealable container for testing for the presence of micro-organisms is provided with or adapted to receive a sample in a first substantially rigid transparent compartment, a growth medium in a second compartment, and a sanitizer in a third compartment, the compartments being separated by foil seals, the second... Agent: Zyzeba Testing Limited

20120115215 - Light source reflector: A light source reflector includes a structure having three or more internal reflective surfaces defining a first light entry aperture and a second light exit aperture having an area that is greater than the area of the entry aperture. A single light source, or a plurality of uniformly distributed light... Agent: Li-cor, Inc.

20120115217 - Device and method for photosynthetic culture: A device and system for growing a photosynthetic culture is provided which employs one or a plurality of vertically disposed photopanels having interior cavities configured for holding liquid and the photosynthetic culture such as algae. The inner chamber of the photopanels may have a shape that is structurally supported by... Agent:

20120115218 - Bioreactor comprising a mixing chamber: The invention relates to a bioreactor (1) comprising a reactor vessel (41) having a mixing chamber (3) separated by a partition (44) from a reaction chamber (2) located generally above the mixing chamber (3), the mixing chamber (3) having an inlet system (4) for influent or a mixture of influent... Agent: Paques Bio Systems B.v.

20120115220 - Anti-microrna oligonucleotide molecules: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.... Agent: Rockefeller University

20120115219 - High affinity binding site of hgfr and methods for identification of antagonists thereof: Use of a polynucleotide encoding or a polypeptide comprising at least the extra-cellular IPT-3 and IPT-4 domains of hepatocyte growth factor receptor for the screening and/or development of pharmacologically active agents useful in the treatment of cancer, preferably a cancer with dysregulation of hepatocyte growth factor receptor.... Agent: Metheresis Translational Research Sa

20120115221 - Sparc-derived tumor rejection antigenic peptides and medicaments comprising the same: (B) a peptide which consists of an amino acid sequence comprising a substitution or addition of one or several amino acids with respect to the peptide consisting of the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has capacity to induce... Agent: Onco Therapy Science, Inc.

20120115222 - Composition and method for maintenance, differentiation, and proliferation of stem cells: Compositions and methods for the proliferation, differentiation, and maintenance of stem cells are described. Preferred are the use of hematopoietic stem cells in combination with a collagen matrix.... Agent: Purdue Research Foundation

20120115223 - Preparation of inactivated artificial antigen presenting cells and their use in cell therapies: Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their generation and use in cell therapy compositions comprising activated cytotoxic T lymphocytes. Inactivated aAPCs are advantageously generated through crosslinking, such as via a photoreaction involving a... Agent:

20120115224 - Culture methods of bone marrow stromal cells and mesenchymal stem cells, and manufacture method of graft cells for central nerve system diseases therapy: In a culture method of the present invention, by culturing bone marrow stromal cells or mesenchymal stem cells under a pseudo micro-gravity environment generated by multi-axis rotation, bone marrow stromal cells or mesenchymal stem cells having an average cell size smaller than that before the culture are obtained. The bone... Agent: Mitsubishi Heavy Industries, Ltd.

20120115226 - 3d culturing systems for growth and differentiation of human pluripotent stem (hps) cells: The present invention relates to the use of 3D culturing systems for the derivation of hepatocyte-like cells from human pluripotent stem cells (hPS). In particular, the invention concerns the directed differentiation and maturation of human pluripotent stem cells into hepatocyte like cells in 3D hollow fiber capillary bioreactors.... Agent: Cellartis Ab

20120115225 - Reprogramming of somatic cells with purified proteins: Purified somatic cell reprogramming factors are described herein. The factors are particularly useful alone or in combination with at least one effector of cellular metabolism, in order to generate at least one reprogramming somatic cell. Methods for using at least one somatic cell reprogramming factor and at least one somatic... Agent:

20120115227 - Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements: The present invention relates to a gene transfer vector (GTV) and in particular to an integrating gene transfer vector (IGTV), which comprises at least one genetic insulator element (GIE), wherein the each comprises at least two copies of an element selected from the group consisting of: a CTF binding site;... Agent: Centre National De La Recherche Scientifique

20120115228 - Oligomeric compounds and compositions for the use in modulation of micrornas: Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapeutic index. Further provided are methods for selectively modulating miRNA... Agent: Isis Pharmaceuticals, Inc.

20120115229 - Embryonic stem cells and neural progenitor cells derived therefrom: The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving... Agent: Es Cell International Pte Ltd.

20120115230 - Phenylpropanoid related regulatory protein-regulatory region associations: Materials and methods for identifying lignin regulatory region-regulatory protein associations are disclosed. Materials and methods for modulating lignin accumulation are also disclosed.... Agent: Ceres, Inc.

20120115231 - Novel lysophospholipid acyltransferase: The present invention provides novel lysophospholipid acyltransferases. The object of the present invention is attained by the nucleotide sequences of SEQ ID NOs: 1 and 6 and the amino acid sequences of SEQ ID NOs: 2 and 7 of the present invention.... Agent:

20120115232 - Method for inducing degradation of protein in mammalian cell: Provided is a system which can induce the degradation of a protein of interest in a mammalian cell system reliably and stably within a short time. A mammalian cell inducible for protein degradation, the degradation of a protein of interest being induced by an auxin, in which the mammalian cell... Agent: Osaka University

20120115233 - Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof: The present invention relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the leafhopper ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation... Agent: Intrexon Corporation

20120115234 - Down-regulation of gene expression using artificial micrornas: Isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression are described.... Agent:

20120115235 - Enhanced cellulase expression in s. degradans: The invention provides organisms and methods of using and making organisms with enhanced cellulase expression.... Agent: University Of Maryland

  
05/03/2012 > 149 patent applications in 78 patent subcategories. archived by USPTO category

20120107791 - Compositions and methods for prolonging survival of platelets: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to... Agent:

20120107793 - Sample processing system and method of processing sample: A sample processing system comprising: a transporting device that transports a sample; a plurality of sample processing devices that are arranged along a transport path for the sample transported by the transporting device and configured to process the sample transported by the transporting device based on a processing order; a... Agent:

20120107792 - Systems and methods for delivery of gases to algal cultures: Photobioreactors according to embodiments of the present invention deliver nutrient gas intermittently to the photobioreactor media. In some embodiments, one or more gases are delivered according to a duty cycle or timing pattern. According to some embodiments, algae is grown in a photobioreactor using intermittent introduction of carbon dioxide. In... Agent:

20120107794 - Cross-coupled peptide nucleic acids for detection of nucleic acids of pathogens: The present invention concerns methods for detecting a nucleic acid comprising (i) contacting a solution comprising a first PNA having a first cross-reactive functional group with a substrate having a second PNA affixed thereto, the second PNA having a second first cross-reactive functional group, wherein the first PNA has a... Agent:

20120107797 - Genotyping of bovine papillomavirus genotypes: The present invention is concerned with the provision of diagnostic means and methods. Specifically, it relates to a composition comprising oligonucleotides selected from at least two different groups of oligonucleotides, said groups comprising at least one pair of oligonucleotides being capable of specifically amplifying polynucleotides comprised by a Bovine Papillomavirus... Agent: Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Offentlichen Rechts

20120107796 - Methods and kits to detect new h1n1 \"swine flu\" variants: Methods and kits used in the detection of the H1N1/09 influenza virus are disclosed. The methods comprise methods of using the nucleic acids to detect H1N1/09 generally as well as H1N1/09 variants resistant to antiviral compositions.... Agent: The Translational Genomics Research Institute

20120107795 - Methods for concurrent identification and quantification of an unknown bioagent: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis,... Agent: Ibis Biosciences, Inc.

20120107798 - Single molecule sensitive probes for detecting rna: The various embodiments of the present disclosure relate generally to single molecule sensitive probes for detecting RNA, and more particularly to multivalent fluorescent probes for detecting a single molecule of RNA in a cell. The present invention includes a RNA imaging probe comprising: a multivalent core comprising a plurality of... Agent: Georgia Tech Research Corporation

20120107800 - Cell-targeting nanoparticles and uses thereof: The invention generally refers to a cell-targeting nanoparticle, wherein the cell-targeting nanoparticle is directly conjugated to at least one cysteine-containing peptide, wherein the cysteine-containing peptide is selected from the group consisting of glutathione (GSM, a GSH-containing peptide, and a peptide comprising a nuclear localization signal (NLS) sequence and a transporter... Agent:

20120107804 - Disintegration of cellular components in body fluids: The present invention refers to a method of processing a biological fluid which comprises cellular components by a freezing/thawing treatment. The method is particularly useful for preparing biological samples for analyte detection.... Agent: Sebo Gmbh

20120107799 - Disposable, rapid extraction apparatus and methods: An extraction apparatus and methods adapted to extract and preferably also isolate structures of interest from a test sample. The extraction apparatus contains a volume-dispensing mechanism that facilitates control over the injection of a sample suspected of containing a structure of interest into a filtration vessel that contains a membrane... Agent: Longhorn Vaccines & Diagnostics LLC.

20120107805 - Generating a fluid stream in a microfluidic device: A fluid handling and delivery system useful in generating a fluid stream in the flow path of microfluidic device.... Agent:

20120107801 - High-efficiency homologous recombination in the oil-producing alga, nannochloropsis: Transformation methods are provided for introducing deoxyribonucleic acid (DNA) into the nucleus of an algal cell. A transformation construct may be prepared, with the transformation construct having a first sequence of DNA similar to a corresponding first sequence of nuclear DNA, a second sequence of DNA similar to a corresponding... Agent:

20120107806 - Method and kits for repairing nucleic acid sequences: Methods and kits for DNA repair are provided. The methods and kits described herein repair multiple types of DNA damage. The kit may include a plurality of enzymes to repair a greater variety of lesions than any single enzyme is capable of repairing. Repair of damaged DNA may include releasing... Agent: General Electric Company

20120107803 - Method for enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates: A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a second fluorescent labeled antibody having binding specificity for a surface marker for platelets, and a nucleic... Agent: Litron Laboratories, Ltd.

20120107802 - Method for sequencing a heteropolymeric target nucleic acid sequence: The invention relates to a method for sequencing a heteropolymeric target nucleic acid sequence that involves stochastic sensing. The invention also relates to a method for improving a pore for sequencing a target nucleic acid sequence by modifying one or more sites in the pore.... Agent: Isis Innovation Limited

20120107811 - Burstable liquid packaging and uses thereof: The present invention relates to systems, devices, and methods for performing biological and chemical reactions. In particular, the present invention relates to the use of burstable liquid packaging for delivery of reagents to biological and chemical assays.... Agent:

20120107819 - Detection of clostridium difficile: The invention provides methods to detect C. difficile in biological samples using real-time PCR. Primers and probes for the detection of C. difficile are provided by the invention. Articles of manufacture containing such primers and probes for detecting C. difficile are further provided by the invention.... Agent:

20120107818 - Detection of multiple nucleic acid sequences in a reaction cartridge: The present invention relates to a method for amplifying and detecting nucleic acid sequences in a reaction cartridge comprising the following steps, (i) providing a sample comprising at least one nucleic acid molecule, (ii) in a first reaction chamber of the cartridge providing reagents for an amplification reaction, (iii) mixing... Agent: Qiagen Gmbh

20120107810 - Epigenetic markers for the identification of blood sub-cells of type 1: The present invention relates to a method, in particular an in vitro method, for identifying CD3CD4 positive T lymphocytes of a mammal, wherein said method comprises analysing the methylation status of at least one CpG position in the CD3a/b/c/d/g genes, in particular their “upstream” regulatory regions, and in particular the... Agent:

20120107808 - High throughput detection of gene-specific hydroxymethylation: This invention provides a method for the detection of hydroxymethylation patterns in a DNA sample, especially in genetic regions. A test sample containing hydroxymethylated DNA is hybridized to capture oligonucleotides immobilized on a solid phase. The hydroxymethylated DNA in hybrid is detected using an antibody which specifically recognizes hydroxymethylcytosine structure... Agent:

20120107807 - Highly sensitive method for the detection of cytosine methylation patterns: The present invention concerns a method for the detection of cytosine methylation in DNA samples, wherein the following steps are conducted: (a) a genomic DNA sample, which comprises the DNA to be investigated and background DNA, is chemically treated in such a way that all of the unmethylated cytosine bases... Agent:

20120107812 - Means and methods for investigating nucleic acid sequences: The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid. The invention further provides improved calibrators which are particularly suitable for determining (pseudo)gene variants and copy number variation.... Agent:

20120107814 - Method for determining the predisposition of a patient to changed biotransformation and to the development of undesired drug effects in a treatment of the patient with atrovastatin: A method for determining a predisposition of a patient to the development of muscular diseases and/or to changed biotransformation in a treatment of the patient with atorvastatin is disclosed. The presence of at least one single nucleotide polymorphism (SNP) in the UGT1A3 gene (uridine diphosphate glucuronosyltransferase gene 1A3) and/or an... Agent: Robert Bosch Gmbh

20120107809 - Method for simultaneously detecting histoplasma capsulatum and paracoccidioides brasiliensis: The present invention relates to a method for simultaneously detecting DNA of Histoplasma capsulatum and Paracoccidioides brasiliensis by means of the real-time quantitative multiplex PCR technique, based on specific probes marked with different fluorophores. This technique is applicable both in biological samples and microbiological cultures and environmental samples. Furthermore, another... Agent: Instituto De Salud Carlos Iii

20120107820 - Multiplexed quantitative pcr end point analysis of nucleic acid targets: Certain embodiments of the present invention are directed to one pot multiplexed quantitative PCR methods for end point analysis of a plurality of nucleic acid targets in a complex sample without user intervention, and to various encoded particles on which are immobilized one or more probes that hybridize with the... Agent: Massachusetts Institute Of Technology

20120107815 - Polymorphism detection probe, polymorphism detection method, evaluation of drug efficacy, and polymorphism detection kit: The invention provides a probe which detects a polymorphism in the MDR1 gene. The probe has a P1 and/or a P2 oligonucleotide. The P1 oligonucleotide has a sequence that is complementary to a first base sequence, in which the first base sequence is a partial sequence of SEQ ID NO:... Agent: Arkray, Inc.

20120107816 - Primer set for detecting egfr exon 21 polymorphism and application thereof: The invention provides a primer set for detecting a polymorphism in EGFR exon 21 L858R. The primer set has a P1 oligonucleotide and a P2 oligonucleotide and can performing amplification by using a region including the 172792nd base of SEQ ID NO: 1 as a template. As a base that... Agent: Arkray, Inc.

20120107817 - Probe for detection of polymorphism in egfr gene, amplification primer, and use thereof: A polymorphism-detecting probe, an amplification primer and the use thereof are provided to enable simple and highly reliable determination of different polymorphisms in an EGFR gene.... Agent:

20120107813 - Quantification of nucleic acids: The invention relates to a method for the quantification of one or more nucleic acids in a sample. The method comprises the following steps: making a sample available which contains at least one nucleic acid to be quantified, adding an oligonucleotide probe to the sample, the oligonucleotide probe comprising a... Agent: Qiagen Gmbh

20120107822 - Method of delivering pcr solution to microfluidic pcr chamber: The present invention relates to systems and methods of performing in-line mixing of assay components and delivery of such mixed components into microfluidic channels. In one aspect, a method of delivering mixed assay components is provided which comprises causing an unmixed primer solution to flow into a first mixing channel,... Agent:

20120107825 - Methods and compositions for assessing patients with reproductive failure using immune cell-derived microrna: The invention is directed to methods and compositions for collecting immune cells, preferably peripheral blood mononuclear cells (PBMCs), before or after an intervention, extracting microRNA-comprising RNA from said cells, quantifying microRNAs within the extracted RNA, determining one or more microRNAs that display a bimodal response amongst a statistically sufficient number... Agent:

20120107821 - Methods for the diagnosis and prognosis of leukemia and other cancer types: Methods for diagnosing leukemia and other cancer types, so that the malignancy thereof dependent on expression of ARTS at low levels or an absence of ARTS expression are disclosed. Moreover methods for prognosis of leukemia and other cancer types, which are prone for an effective treatment by restoring ARTS expression... Agent:

20120107823 - Micro-device and methods for disrupting cells: A micro-device for disrupting cells includes a first chamber in which the cells are disrupted, a second chamber which is pressurized and depressurized, a flexible membrane which separates the first chamber and the second chamber and is vibrated by pressuring and depressurizing the second chamber, and a micro-unit confined in... Agent: Samsung Electronics Co., Ltd.

20120107824 - Mpcr methods for analyzing repeat sequences: Methods are provided for determining the methylation status of GC-rich templates. The methods include use of GC reference standards that allow simultaneous characterization of methylation status and CGG repeat length. The methods are useful for detecting genotypes associated with GC-rich repeats, including Fragile X Syndrome.... Agent:

20120107826 - Znf217 a new prognostic and predictive biomarker of recurrent invasive and metastatic phenotypes in breast cancer: The present invention relates to methods for determining the prognosis of a cancer. The methods involve determining the level of expression of the ZNF217 gene in a cancer cell sample or in a tumor sample wherein over-expression of ZNF217 is correlated with likelihood of metastasis and with likelihood of relapse/recurrence... Agent: Centre Leon Berard

20120107827 - Psmcs as modifiers of the rb pathway and methods of use: Human PSMC genes are identified as modulators of the RB pathway, and thus are therapeutic targets for disorders associated with defective RB function. Methods for identifying modulators of RB, comprising screening for agents that modulate the activity of PSMC are provided.... Agent: Exelixis, Inc.

20120107828 - Method for identifying a subpopulation of mammalian cells with distinctive ribosome translation profiles: The present invention generally relates to subpopulations of mammalian cells with distinctive ribosome translational profiles, i.e. translational activities. The present invention further relates to methods for identifying and isolating such cells, kits comprising the same, or methods which utilize different translational activities of these subpopulations of mammalian cells.... Agent: Wayne State University

20120107831 - Method for detecting afferent lymph vessel inflow regions and method for identifying specific cells: Regions where metastatic cancer cells can exist are detected with high accuracy in a sentinel lymph node. Quantum dots are injected into the vicinity of a cancer in a living body, thereby identifying the location of the sentinel lymph node by means of fluorescence. Subsequently, the sentinel lymph node is... Agent: Tohoku University

20120107832 - Method for the detection of organ or tissue injury: This invention relates to methodology for detecting, assessing and/or diagnosing the presence of organ or tissue injury. More specifically, the present invention relates to methodology for detecting particular serum biomarkers that can be used in the detection, assessment and/or diagnosis of organ (e.g. liver) or tissue (e.g. skin) injury.... Agent: The University Of Liverpool

20120107830 - Reagents for biomolecular labeling, detection and quantification employing raman spectroscopy: i

20120107829 - Stabilizing compositions for immobilized biomolecules: The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. The invention furthermore relates to a... Agent: Leukocare Ag

20120107838 - Cancer diagnostics: The invention concerns kits and methods for the diagnosis, prognosis and monitoring of cancer. In one aspect, there is provided a method for identifying whether or not a mammal is suffering from cancer, wherein the method comprises the steps of: (a) measuring a signal due to a non-IgG immunoglobulin binding... Agent: Total Scientific Limited

20120107837 - Method for screening anticancer substances, set or kit for implementing said method: e

20120107839 - Nmr device for detection of analytes: This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR... Agent: T2 Biosystems, Inc.

20120107840 - Methods for label free testing of cells: The invention provides methods of detecting activation of an immune cell, methods for detecting blocking or enhancing properties of a test reagent or stimuli on activation of one or more immune cells or platelets, methods for selecting hybridomas producing antibodies to an antigen for quality of strength of binding to... Agent: Sru Biosystems, Inc

20120107833 - Antibody specific for a mammalian sphingosine kinase type 2 isoform protein and methods of use thereof: Polyclonal or monoclonal antibodies which are specific for a mammalian sphingosine kinase type 2 isoform protein and methods for detecting the presence of sphingosine kinase type 2 isoform using the antibodies.... Agent: Sankyo Company, Limited

20120107834 - Encapsulated reagents and methods of use: The present invention contemplates use of encapsulated aqueous and non-aqueous reagents, solutions and solvents and their use in laboratory procedures. These encapsulated aqueous or non-aqueous reagents, solutions and solvents can be completely contained or encapsulated in microcapsules or nanocapsules that can be added to an aqueous or non-aqueous carrier solution... Agent:

20120107835 - Method for detecting beta-amyloid using amino acid dimers: A method for detecting β-amyloid using an amino acid dimer instead of a secondary antibody binding to the β-amyloid primary antibody in an immunoassay based on an antigen-antibody reaction, and a kit for detecting β-amyloid including the dimer. The method is advantageous in that the dimer has good properties in... Agent: Electronics And Telecommunications Research Institute

20120107836 - Development of fluorescently p-loop labelled kinases for screening of inhibitors: The present invention relates to a kinase labelled at an amino acid naturally present or introduced in the P-loop of said kinase, wherein said labelling is effected at a free thiol or amino group of said amino acid and said label is (a) a thiol- or amino-reactive fluorophore sensitive to... Agent:

20120107843 - Anti bone-loss and anti attachment-loss effects of an oral composition: Methods for identifying compounds useful for treating diseases and conditions of the oral cavity are described herein.... Agent: Colgate-palmolive Company

20120107845 - Disrupting fcrn-albumin interactions: Provided herein are, inter alia, methods for identifying a candidate compound for treating the toxic effects of compounds or molecules that bind to albumin in a subject. The methods include identifying test compounds that inhibit the binding between FcRn and albumin.... Agent: The Brigham & Women's Hospital, Inc.

20120107844 - Immunosorbent assay support and method of use: Embodiments of the present invention provide an immunosorbent assay support immobilized with an intermediate binding antibody and their method of use in an improved immunoassay format.... Agent: Life Technologies Corporation

20120107846 - Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using elisa assays: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic... Agent:

20120107842 - Method for detecting antibody against sith-1 in biological sample: e

20120107841 - Serum diagnostic method, biomarker and kit for early detection and staging of alzheimer's disease: A laboratory method for screening, diagnosing, monitoring and/or staging early onset Alzheimer's disease which consists of mild cognitive impairment entails conducting a blood test after an oxidative exposure of serum to assay for the presence of an elevated level of redox-reactive autoantibodies.... Agent:

20120107847 - Testing efficacy for celiac disease: determining whether there is a change in condition of celiac disease or gluten intolerance of the one or more patients that results from administration of the compound or composition and challenge with gluten; whereby no significant change in condition indicates that the compound or composition would be effective in treating... Agent: DsmIPAssets B.v.

20120107848 - Polyclonal-monoclonal elisa assay for detecting n-terminus pro-bnp: A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure... Agent: Nexus Dx, Inc.

20120107849 - Coelenterazine derivatives and methods of using same: The invention provides coelenterazine derivatives which are substrates for a non-luminescent enzyme and a pro-substrate for a luminescent enzyme. The invention also provides a method of using the derivatives.... Agent:

20120107850 - Analysis reagent and analysis device having the analysis reagent carried therein: A reagent including a combination of a polyanionic compound and a bivalent cationic compound contains one substance selected from the group consisting of succinic acid, gluconic acid, alanine, glycine, valine, histidine, maltitol, and mannitol or at least one compound of the substance. A dry state of the reagent and deliquescence... Agent: Panasonic Corporation

20120107851 - Lateral flow assay device for coagulation monitoring and method thereof: The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate... Agent:

20120107852 - Method for preparing modified polypeptides: d) optionally subjecting the nucleotide sequence encoding the polypeptide selected in step c) to one or more repeated cycles of steps a)-c). In a further step the expressed polypeptides of step a) or c) can be conjugated to at least one non-polypeptide moiety.... Agent:

20120107853 - Use of genetically modified organisms to generate biomass degrading enzymes: The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga... Agent: Sapphire Energy, Inc.

20120107854 - Reagent for measurement of cholinesterase activity: An N-alkylpiperidine methanethiol ester derivative represented by any one of the general formulae (1) to (4) or a salt thereof has been discovered. The N-alkylpiperidine methanethiol ester derivative or the salt thereof has specificity for acetylcholinesterase or butyrylcholinesterase and is useful as a reagent for measurement of cholinesterase activity by... Agent: National Institute Of Radiological Sciences

20120107858 - Cancer diagnosis method using the glycosylation of a glycoprotein: The present invention relates to a cancer diagnosis method using peptides containing information on the glycosylation of a glycoprotein involving cancer development. More particularly, the present invention relates to a cancer diagnosis method which obtains peptides from the glycoprotein involving cancer development through a hydrolysis process using an enzyme, and... Agent: Korea Basic Science Institute

20120107855 - Crosslinking reagent for analysis of protein-protein interaction: Crosslinking reagents and methods for using the same for analysis of protein-protein interactions, are provided. The crosslinking reagents include a trifunctional scaffold that links two protein linking groups to each other and branches to link an affinity tag, where the protein linking groups can be fragmented from the scaffold. The... Agent: Agilent Technologies, Inc.

20120107857 - Di- and poly-ubiquitin deubiquitinase substrates and uses thereof: Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.... Agent:

20120107859 - Methods for early detection of blood disorders: Disclosed herein are methods of detecting blood disorders, such as diabetes. In particular examples the method includes contacting a blood sample with an amine reagent, blocking an excess of the amine reagent with a blocking reagent, digesting the modified blood sample with trypsin to produce a digested blood sample containing... Agent:

20120107856 - New fungal production system: The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20% of the endogenous cellulase secretion of Chrysosporium lucknowense strain UV 18-25. Preferably, also the secretion of endogenous protease, endogenous β-glucanase and endogenous cellobiohydrolase is... Agent:

20120107860 - Cell sorting apparatus, cell sorting chip, and cell sorting method: Disclosed herein is a cell sorting apparatus, including: a branch portion branching a flow path in which a fluid containing therein cells flows into a first branch flow path, and a second branch flow path; a coupling portion coupling the first branch flow path and the second branch flow path... Agent:

20120107862 - Factors: A method for determining a prognosis for benefit for a cancer patient receiving immunotherapy treatment involving (a) measuring a level of haematocrit and haemoglobin in a sample from the cancer patient, and (b) comparing the level of haematocrit in the sample to a reference level of platelets and comparing the... Agent: Oxford Biomedica (uk) Limited

20120107861 - Method of determining risk of arrhythmia: The present invention relates to a method of determining the risk of drug induced arrhythmia using stem cell derived cardiomyocytes in a high-throughput impedance or multi-electrode array assay.... Agent:

20120107863 - Modulation of telomere length in telomerase positive cells and cancer therapy: Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention of tumorigenic telomerase positive cells from having a chance to grow into a tumor and methods for promoting tumor regression (decrease in size... Agent: Alt Solutions Inc.

20120107865 - Detection of bacteria and fungi: A method of detecting a ligase expressing micro-organism in a sample comprises steps of treating the sample under conditions that inhibit the activity of ATP-dependent ligase from mammalian cells but which do not inhibit the activity of the microbial ligases, contacting the sample or a portion of the sample with... Agent: Momentum Bioscience Ltd

20120107864 - Mass spectrometric rapid detection of salmonella: The invention relates to the detection of specified, flagellated bacteria, particularly Salmonella, in food and stool. A single culturing period of about 12 to 24 hours in a liquid nutrient medium without agitation is combined with a position-selective sampling of the flagellated microbes from the liquid of the culture, after... Agent:

20120107866 - Methods to increase and harvest desired metabolite production in algae: Enhanced yields of photosynthetically fixed carbon produced by hypersaline photosynthetic algae are provided by co-culturing with a halophilic archaea. Further, methods are provided to control harvesting of desired metabolic products from hypersaline photosynthetic algae by controlling caspase activity.... Agent: Institute For Systems Biology

20120107867 - Glycopegylated erythropoietin: The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified... Agent: Novo Nordisk A/s

20120107869 - Organic compounds: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically... Agent: Sandoz Ag

20120107868 - Processes for making protein hydrolysates from animal peptone and for preserving mucosa: A process for hydrolyzing products with enzymatic activity remaining in peptone solutions after mucosa hydrolysis is provided along with a process for preserving mucosa tissue. Broadly, the processes are carried out by hydrolyzing mucosa tissue according to conventional heparin manufacturing processes wherein an excess quantity of proteolytic enzymes is used.... Agent:

20120107870 - Selective enzymatic amidation of c-terminal esters or acids of peptides: p

20120107873 - Method of producing a sweet protein: The present invention relates to a method of producing a recombinant sweet protein in a filamentous fungus. The invention also relates to isolated polynucleotides encoding the sweet protein and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, as well as methods of using the sweet protein produced... Agent: Novozymes A/s

20120107871 - Method of producing human igg antibodies with enhanced effector functions: A method for generating human IgG1 antibodies with enhanced Fc effector function is disclosed. In practicing the method, an IgG1 Fc look-through mutagenesis (LTM) coding library directed at four receptor-contact regions of the Fc CH2 portion in human IgG1. Fc is expressed in a system in which the mutated Fc... Agent: Pfizer Inc.

20120107872 - Thermostable trichoderma cellulase: Described are compositions and methods relating to the thermostable fungal cellulase enzyme, EGV, and Trichoderma host cells having a modification comprising or consisting essentially of disruption or deletion of nucleotide(s) for expression of this cellulose, whereby EGV expression is prevented.... Agent:

20120107874 - Modified host cells and uses thereof: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.... Agent: Eureka Therapeutics, Inc.

20120107875 - Expression cassette, recombinant host cell and process for producing a target protein: Disclosed herein is a process for producing a target protein, in which a recombinant polynucleotide is constructed to encode a fusion protein including: (i) an anchoring protein that includes a N-terminal amino acid sequence of an ice nucleation protein, so that the fusion protein, once expressed in the host cell,... Agent: National Chung-hsing University

20120107877 - Methods and compositions for concentrating secreted recombinant protein: Methods and compositions are described that relate to obtaining concentrated preparations of secreted recombinant proteins. These proteins are expressed in the form of fusion proteins with a chitin-binding domain (CBD). The fusion proteins are capable of being concentrated in the presence of chitin. Also described is: a shuttle vector that... Agent: New England Biolabs, Inc.

20120107876 - Novel fusion tag offering solubility to insoluble recombinant protein: The invention relates to a fusion tag comprising Serine-aspartic acid repeats of the well conserved region of the Staphylococcus aureus Sdr C gene superfamily. A START codon and an enterokinase cleavage site has been incorporated into this repeat region to make a novel fusion tag that is responsible for expressing... Agent: Lupin Limited

20120107878 - Multiplex assembly of high fedelity dna: The present invention relates to novel sequence normalization protocols and methods which utilize this protocol to provide a robust multiplexed assembly of high fidelity polynucleotides/genes... Agent:

20120107879 - Methods for production and purification of nucleic acid molecules: The present invention is directed to methods for the production and isolation of nucleic acid molecules. In particular, the invention concerns isolation of mRNA molecules and the production and isolation of nucleic acid molecules (e.g., cDNA molecules or libraries), which may be single- or double-stranded. Additionally, the invention concerns selection... Agent: Life Technologies Corporation

20120107880 - Fungal strains: The present invention provides improved fungal strains. In some embodiments, the improved fungal strains find use in hydrolyzing cellulosic material to glucose.... Agent: Codexis, Inc.

20120107881 - Compositions and methods for production of fermentable sugars: The present application provides genetically modified fungal organisms that produce enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to glucose, enzyme mixtures produced by the genetically modified fungal organisms, and processes for producing glucose from cellulose using such enzyme mixtures.... Agent: Codexis, Inc.

20120107882 - Recombinant microorganism and method for producing l-lysine: The present invention provides methods of producing L-lysine at a high yield using an Escherichia bacterium, especially E. coli, comprising a wild type or variant dapA gene of B. subtilis. The invention also provides related recombinant Escherichia bacteria, especially E. coli, for use to produce L-lysine.... Agent:

20120107883 - Method for producing 4-hydroxy-l-isoleucine: A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.... Agent:

20120107884 - Method for producing 4-hydroxy-l-isoleucine: A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.... Agent:

20120107885 - Anaerobic fermentation of glycerol: The invention relates to the development of appropriate cultivation conditions for a bacteria to grow anaerobically (fermentatively) on a glycerol substrate. The method requires culturing bacteria having a functional 1,2-propanediol pathway and a functional type II glycerol dehydrogenase-dihydroxyacetone kinase pathway in a culture medium containing high concentrations of glycerol, a... Agent: William Marsh Rice University

20120107886 - Lignin oxidation and products thereof: Provided herein is a method of oxidizing lignin. Further disclosed herein are aromatic and non-aromatic compounds obtained from oxidized lignin.... Agent: Strategic Enzyme Applications, Inc.

20120107888 - Modulation of fermentation products through vitamin supplementation: Improved yields of biofuels and other chemicals are obtained by culturing a cellulolytic microorganism, such as Clostridium phytofermentans, Clostridium sp. Q.D, or Clostridium biocatalysts thereof in modulated amounts of vitamins, such as thiamine or nicotinic acid. Provided are methods to increase yields of ethanol and other fermentation products through vitamin... Agent: Qteros, Inc.

20120107887 - Process for the production of alcohols from biomass: Alcohols useful as fuel compositions are produced from biomass by: contacting the biomass with a cooking liquor containing 1 to 20 wt %, based on the cooking liquor, of sodium hydroxide, and under conditions effective to provide a pulp stream containing pulp having a lignin content of 5% to 20%... Agent: Shell Oil Company

20120107889 - Endophytic yeast strains, methods for ethanol and xylitol production, methods for biological nitrogen fixation, and a genetic source for improvement of industrial strains: The present invention provides novel endophytic yeast strains capable of metabolizing both pentose and hexose sugars. Methods of producing ethanol and xylitol using the novel endophytic yeast are provided herein. Also provided are methods of fixing nitrogen and fertilizing a crop using the novel endophytic yeast strains provided herein.... Agent:

20120107890 - Recovery of higher alcohols from dilute aqueous solutions: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation... Agent: Gevo, Inc.

20120107891 - Recovery of higher alcohols from dilute aqueous solutions: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation... Agent: Gevo, Inc.

20120107892 - Production of ethanol from lignocellulosic biomass: Described herein are methods for converting lignocellulosic biomass to ethanol, comprising the step of contacting the lignocellulosic biomass with a mixture for a period of time at an initial temperature and an initial pH, wherein the mixture comprises a first microorganism and a second microorganism, thereby producing an amount of... Agent:

20120107894 - Methods and compositions for the recombinant biosynthesis of terminal olefins: The present disclosure identifies methods and compositions for modifying microbial cells, such that the organisms efficiently synthesize terminal olefins, and in particular the use of such organisms for the commercial production of propylene and related molecules.... Agent: Joule Unlimited Technologies, Inc.

20120107893 - Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.... Agent: Massachusetts Institute Of Technology

20120107895 - Method and apparatus for membrane-based, two-stage gas production from solid biomaterials: Embodiments of the present invention preferably relate to a method and apparatus for a two-stage membrane-based production of gas, preferably hydrogen gas or the like, from solid biological materials, preferably organic waste materials or the like, comprising anaerobic hydrolysis and fermentation and photofermentation using microorganisms.... Agent: Arrowhead Center, Inc.

20120107897 - Double-stranded oligonucleotides: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the... Agent: Life Technologies Corporation

20120107896 - Method for treating a biological material comprising living cells: A plasma containing at least one reactive species are used to deliver agents into living cells or an extracellular matrix of the living cells. The method and system allows for treatment of the living cells without causing irreversible damage to the cell membranes of the living cells. The plasma is... Agent:

20120107898 - Method for obtaining human microglial precursor cells from pluripotent stem cells: A method for obtaining human microglial precursor cells, comprising: (a) providing a cell population comprising neural precursor cells, wherein the cell population is obtainable from embryoid bodies differentiated from human pluripotent stem cells; (b) differentiating the cell population comprising neural precursor cells into microglial precursor cells by culturing in medium... Agent:

20120107899 - Heat-stable carbonic anhydrases and their use: The present invention relates to use of Caminibacter carbonic anhydrase in CO2 extraction, e.g., from flue gas, natural gas, biogas or ambient air. The Caminibacter carbonic anhydrases are especially well suited for these purpose due to their extreme thermostability.... Agent: Novozymes A/s

20120107900 - Electrospun polymer fibers comprising particles of bacteria-containing hydrogels: The electrospun polymer fibers according to the present invention comprising bacteria-containing hydrogels are suitable for use in the dry storage of useful bacteria or for killing harmful bacteria. Textiles and membranes, for example, are suitable to be equipped with it. However, they are also suitable for applications in wastewater treatment,... Agent: Philipps-universitat Marburg

20120107901 - Method of treating the surface of a medical device with a biomolecule: A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid... Agent: Ension, Inc.

20120107903 - Mutant glucose dehydrogenase: A mutant glucose dehydrogenase having an amino acid sequence at least 80% identical to SEQ ID NO:3 and having glucose dehydrogenase activity, wherein amino acid residues corresponding to positions 326, 365 and 472 of said amino acid sequence are replaced with glutamine, tyrosine and tyrosine, respectively, and wherein said mutant... Agent: Arkray, Inc.

20120107902 - Processes for forming amide bonds and compositions related thereto: The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an O-silylated thionoester and an amine under conditions such that an amide is formed. In another embodiment, the disclosure relates to mixing a... Agent: Emory University

20120107904 - Carboxy terminal residues as predictors and regulators of protein stability: Compositions and methods are provided that are useful for predicting and controlling the stability of expressed polypeptides. The compositions and methods may be used to predict and as desired, increase or decrease the stability of proteins recombinantly expressed in mycobacteria, for example DesA3 expressed in Mycobacterium smegmatis. At the C... Agent:

20120107905 - Variants of fungal serine protease: The present invention relates to fungal serine protease variants, which comprise an amino acid substitution of valine at position 208 of the parent Fusarium equiseti Fe_RF6318 serine protease, wherein the position of the substitution corresponds to the amino acid sequence of the mature Fe_RF6318 enzyme defined in SEQ ID NO:2.... Agent: Ab Enzymes Oy

20120107906 - Novel lipolytic enzyme lip1: The present invention provides a novel nucleic acid sequence, designated LIP1, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for... Agent:

20120107907 - Thermostable neutral metalloproteases: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus... Agent:

20120107908 - Enzymatic formulation and composition for co2 capture reactions: A triphasic bioreactor and process for physico-chemically treating a gas includes a reaction chamber and its use with a liquid and biocatalysts in suspension, for catalyzing a reaction between the gas and the liquid to obtain a treated gas and a solution containing a reaction product. An enzymatic formulation for... Agent: Co2 Solution Inc.

20120107912 - Cell lysis device and methods of lysing cells or viruses: A method of lysing at least one of a cell and a virus, the method including: contacting a sample, which includes at least one of a cell and a virus, with a plurality of beads which are disposed in a first chamber to obtain a combination of the sample and... Agent: Samsung Electronics Co., Ltd.

20120107909 - Novel hiv-2 isolate: The invention provides a novel strain of HIV-2 capable of causing immunodeficiency. The invention also provides compositions comprising the nucleic acids and polypeptides characteristic of this HIV-2 virus, antibodies specific for this HIV-2 virus, methods of using these compositions, and methods of detecting HIV-2 virus.... Agent:

20120107910 - Recombinant envelope protein of human immunodeficiency virus (hiv) and vaccine containing the same: The present invention provides a recombinant HIV Env antigenic protein, a virus-like particle and a recombinant HIV virus. The present invention further provides a vaccine comprising the recombinant HIV Env antigenic protein, the virus-like particle or recombinant HIV virus.... Agent:

20120107911 - Recombinant hemagglutinin protein of influenza virus and vaccine containing the same: The present invention provides a recombinant hemagglutinin antigenic protein, a virus-like particle and a recombinant influenza virus. The present invention further provides a vaccine comprising the recombinant hemagglutinin antigenic protein, the virus-like particle or recombinant influenza virus.... Agent:

20120107913 - Microorganism culture sheet and manufacturing method therefor: A microorganism culture sheet is provided which can limit the use of a costly cultivation material to a necessary portion, which has simple production at the time of manufacture, and can be simply and stably used by a user. The microorganism culture sheet of the present invention is a microorganism... Agent: Dai Nippon Printing Co., Ltd.

20120107914 - Microbial activity improvement agent, microbial activity improvement method, and biological waste treatment method: A compound selected from the group consisting of 4-quinolone and derivatives thereof, homoserine lactone derivatives, and indole and derivatives thereof, and salts thereof have an action of a microbial activity improvement agent, and when it is used for a microbial activity improvement method and a biological waste treatment method, the... Agent: Sumitomo Heavy Industries, Ltd.

20120107915 - Method for high-throughput identification of microbial antagonists against pathogens: The present invention relates to high-throughput methods of screening biological samples to identify microorganisms having potential utilities as biocontrol agents. The methods include, for example, the use of multitest platforms for the simultaneous identification of microorganisms having biocontrol activity, including those useful in improving plant, animal, and human health. In... Agent: Synthetic Genomics, Inc.

20120107916 - Methods and compositions for affecting the differentiation of clostridia in culture: The invention relates generally to methods and compositions for maintaining and manipulating microbial cultures of Gram-positive bacteria. Also provided are methods for identifying quorum sensing regulatory proteins and auto-inducing peptides in Gram-positive bacteria. Also provided are methods and compositions for affecting quorum sensing pathways of the genus Clostridium in culture... Agent:

20120107917 - Novel microorganism and method for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using the novel microorganism: This invention relates to a novel microorganism that efficiently produces a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. As a result of concentrated studies, a plurality of novel microorganisms having properties of interest that are not classified as conventional microorganisms were isolated and identified. The novel microorganism of the present... Agent: Kao Corporation

20120107919 - Method for producing biomass and photobioreactor for cultivating phototrophic or mixotrophic organisms or cells: According to the proposed method for producing biomass, the organisms or cells in a suspension kept in circulation in a photobioreactor are cultivated with introduction of light and of at least CO2 as a nutrient. For the cultivation, the suspension is introduced via at least one introduction organ in an... Agent: Igv Institut Fuer Getreideverarbeitung Gmbh

20120107918 - Methods of algal growth in photobioreactors: The present invention provides novel photobioreactors, modules thereof, and methods for use in culturing and harvesting algae and cyanobacteria.... Agent:

20120107920 - Method of producing sugar solution and saccharification device: To achieve efficient use of enzyme in obtaining a sugar solution through a reaction of the enzyme and biomass containing cellulose. In obtaining a sugar solution through a reaction of enzyme and biomass containing cellulose, the biomass and the enzyme are caused to react in a first reaction tank, whereby... Agent: Jgc Corporation

20120107921 - Model based controls for use with bioreactors: Embodiments of the present invention include model-based controls to control photobioreactor operation and the growth of algae for use as a biofuels feedstock. In some embodiments, the model-based control can accounts for future conditions such as weather, product pricing, customer demands and/or other variables to operate the reactors in a... Agent: Solix Biofuels, Inc.

20120107922 - Tampering device used during embedding of biological tissue samples: A tampering device may comprise a tamper, an elongated handle, and an insulator rod. The elongated handle may have a first end and a second end. The insulator rod may be adapted to connect to the tamper and the first end of the elongated handle. The elongated handle may have... Agent:

20120107923 - Expression vectors which inhibit synthesis of catalase and uses thereof: Vector and application of a medicine/drug that inhibits the intake of alcohol for prolonged periods, by inhibiting the synthesis of brain catalase or by destroying the product that is generated when brain catalase acts upon ethyl alcohol.... Agent:

20120107926 - Apparatus for cell or tissue culture: The apparatus for cell or tissue culture comprises a base plate (1), an intermediate face (2) and a top plate (3). The intermediate face (2) is removably sandwiched between the base plate (1) and the top plate (3). The base plate (1) has a circumferential wall (13), a base (14)... Agent:

20120107924 - Compositions and methods for modifying cell surface glycans: Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.... Agent:

20120107925 - Devices for separating cells and methods of using them: The present invention refers to a device for separating cells of a defined size from a sample and to a system comprising such devices and further components. Such devices can comprise different components, such as inlet module, intermediate module, outlet module and microsieve. The present invention also refers to methods... Agent:

20120107927 - Methods and devices for isolating embryonic stem cells: Methods, devices and kits are provided for isolating or enriching multicellular embryonic stem (ES) cell colonies from a mixture of multicellular ES cell colonies and single ES cells present in a cellular suspension, by utilizing a filtration matrix that selectively excludes passage of multicellular ES cell colonies. Isolated or enriched... Agent: Proteonomix, Inc.

20120107928 - Antibody inhibitors of gdf-8 and uses thereof: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.... Agent: Wyeth LLC

20120107929 - Variable lymphocyte receptors, related polypeptides and nucleic acids, and uses thereof: Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs).... Agent: The Uab Research Foundation

20120107930 - Method for inducing differentiation of embryonic stem cells or artificial pluripotent stem cells: s

20120107931 - Differentiation of primate pluripotent stem cells to hematopoietic lineage cells: The invention provides methods of differentiating primate pluripotent stem cells into cells of hematopoeitic lineage. The invention further provides hematopoietic lineage cells differentiated from primate pluripotent stem cells, as well as methods of using the same and kits comprising the same.... Agent: Geron Corporation

20120107933 - Anti-mesothelin antibodies: The present invention provides monoclonal anti-mesothelin antibodies and antibody fragments and methods for their use. The antibodies can be completely human.... Agent: The Government Of The United States, As Represented By The Secretary Of The Dept. Of Healt

20120107932 - Prrs-virus receptor and its inhibitor: This invention relates to a new cell receptor of the PRRS virus, i.e. as non-muscle myosin II-A (NMHC II-A)and its inhibitor blebbistatin, which can be used as a drug for suppressing PRRS virus infection of cells. The invention provides a method of utilizing purified NMHC II-A protein, artificially synthesized polypeptides... Agent:

20120107934 - Human late stage motor neuron progenitor cells and methods of making and using same: Motor neuron progenitor (MNP) cells and populations of MNP cells, are provided, in particular, populations of human late stage MNP cells having a purity of greater than about 65% late stage MNP cells and high-purity populations of MNP cells having greater than 95% viable cells, as well as method of... Agent: California Stem Cell, Inc.

20120107935 - Simplicity in assembling microstructures: Concept and examples are provided for simplicity in assembling micro-culture structures. A cell culture could be started prior to the formation of a microstructure. Cultured cells are utilized as glue and spacers to measure and assemble the microstructure automatically.... Agent:

20120107936 - Cultured pancreas islets: Methods of preparing pancreatic islets that may comprise pancreatites are provided. The methods may involve subjecting a pancreas and/or pieces thereof to disruption, such as, for example, an enzyme digest, and seeding the recovered cellular product comprising islets in a culture medium comprising at least a detectable amount of endocrine... Agent: Cell & Tissue Systems, Inc.

20120107937 - Mitochondrial enhancement of cells: Certain embodiments disclosed herein include, but are not limited to, at least one of compositions, methods, devices, systems, kits, or products regarding rejuvenation or preservation of stem cells. Certain embodiments disclosed herein include, but are not limited to, methods of modifying stem cells, or methods of administering modified stem cells... Agent: Searete LLC, A Limited Liability Corporation Of The State Of Delaware

20120107938 - Methods and kits for high efficiency engineering of conditional mouse alleles: The present invention concerns methods and kits for the direct, targeted engineering of conditional alleles in rodent embryonic stem cells in which the conditional allele is replaced with a DNA of interest without first introducing heterotypic recombination sites, thus providing high efficiency targeted exchange of genetic material.... Agent: University Of Basel

20120107939 - Down-regulation of gene expression using artificial micrornas: Isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression are described.... Agent:

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