|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology April category listing, related patent applications 04/12Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 04/26/2012 > 102 patent applications in 54 patent subcategories.
20120100521 - Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids: Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily... Agent:
20120100523 - Oxygen depletion devices and methods for removing oxygen from red blood cells: An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are... Agent:
20120100522 - Stabilized chemical dehydration of biological material: The present invention provides compositions and methods that enable the stabilization and storage of samples by contacting a sample with an assembly of particles, and reducing the water activity level of the contacted sample. By reducing the water activity level of the sample, the assembly of particles minimizes the degradation... Agent: Genvault Corporation
20120100524 - Tubular floating electrode dielectric barrier discharge for applications in sterilization and tissue bonding: Disclosed is a device and method for contacting a biological substrate. A non-thermal plasma device delivers a non-thermal plasma discharge using a dielectric conduit, an igniter electrode and a RF electrode. The dielectric conduit fluidicly communicates a gas therethrough and an igniter electrode ionizes at least a portion of the... Agent: Drexel University
20120100525 - Ultrasound enhanced growth of microorganisms: A method of increasing the rate of growth, useful product production, or protein expression of a microorganism includes the step of exposing the microorganism to ultrasound having a frequency greater than about 1 MHz.... Agent: Intelligentnano Inc.
20120100529 - Biological specimen collection and transport system and methods of use: Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing... Agent: Longhorn Vaccines & Diagnostics, LLC
20120100526 - Identification and differentiation of nucleic acid sequence using temperature-dependent hybridization: Oligonucleotide probes are provided that are capable of hybridizing to different target nucleic acid sequences in a temperature-dependent manner allowing for detection of more than one target sequence by the same probe or by different probes having reporter labels with identical or similar detection characteristics. Also provided is a method... Agent: Smiths Detection Inc.
20120100528 - Method for detection of human papillomavirus (hpv) type: The present invention describes a method for detection of human papillomavirus (HPV) types and a kit for detection of said HPV types.... Agent:
20120100527 - Method of detecting h5 or h7 avian influenza virus: The present invention provides oligonucleotide primers specifically hybridizing to an arbitrary nucleotide sequence designed from the nucleotide sequence of hemagglutinin of an H5 or H7 avian influenza virus, a nucleic acid amplification method using the primers, a method for diagnosis of infection with an H5 or H7 avian influenza virus... Agent: Eiken Kagaku Kabushiki Kaisha
20120100531 - Coated substrates comprising a cell extractant and biodetection methods thereof: Articles are provided for the detection of cells in a sample. The articles include a release element. The release element comprises a coated substrate that includes a cell extractant. The release element controls the release of the cell extractant into a liquid mixture containing the sample. Methods of use are... Agent: 3m Innovative Properties Company
20120100530 - Enzyme mutant: The invention relates to constructs comprising a nucleic acid binding protein and a surface. At least one native accessible cysteine residue is removed from the binding protein. The binding protein is attached to the surface via one or more accessible cysteine residues. The removal of other accessible cysteine residues from... Agent: Oxford Nanopore Technologies Limited
20120100533 - Method for determining the cardio-generative potential of mammalian cells: This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation Potential Index (CARPI) as a function of the quantification of the expression of genes of said cells. It also relates to a method for quantitatively assessing the... Agent: Mayo Foundation For Medical Education And Research
20120100532 - Method for imaging and differential analysis of cells: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.... Agent: Amnis Corporation
20120100536 - Association of htra1 mutations and familial ischemic cerebral small-vessel disease: The present invention provides a method of diagnosing a cerebrovascular disease in a human comprising the steps of: (a) measuring a mutation of HTRA1 gene in a test sample from said human; and (b) determining if the mutation of HTRA1 gene in said test sample correlates with a cerebrovascular disease... Agent: The University Of Tokyo
20120100543 - Compositions for the use in identification of fungi: The present invention provides compositions, kits and methods for rapid identification and quantification of fungi by molecular mass and base composition analysis.... Agent: Ibis Biosciences, Inc.
20120100538 - Devices and methods of cell capture and analysis: The present invention provides a device for isolating target biomolecules or cells from samples, particularly biological samples. In particular, the device comprises a loading mixture, which contains the biological sample and a first binding entity that specifically binds to the target biomolecule or target cell; and a micro-channel coated with... Agent: Biocept, Inc.
20120100534 - Efficient base determination in sequencing reactions: The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid... Agent: Complete Genomics, Inc.
20120100541 - Gene methylation in cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use in detecting and diagnosing cancer.... Agent: Orion Genomics LLC
20120100545 - Method and/or primers for the detection of mycobacterium tuberculosis: The invention provides oligonucleotide(s) for simple, specific and/or sensitive test(s) for the presence of Mycobacterium tuberculosis. In particular, the present invention provides oligonucleotide(s) for test(s) for Mycobacterium tuberculosis. Kit(s) comprising the oligonucleotide(s) for use as probe(s) and/or primer(s) useful in the test(s) are also provided.... Agent: Agency For Science, Technology And Research
20120100542 - Method for detection of target nucleic acid, and method for testing for colon cancer: The present invention provides: a method for easily and simply obtaining highly reliable results of the detection of a target nucleic acid from nucleic acids that are directly recovered from feces; and a method for testing for diseases, particularly colon cancer, by using this method. Specifically, the present invention is... Agent: Olympus Corporation
20120100539 - Method for determining risk for kidney stones developing or recurring and method for using single-nucleotide polymorphism rs12313273 as biomarker for determining development or recurrence of kidney stone: The invention provides a method for determining a risk for kidney stones to develop in a subject, including: obtaining a biosample of the subject; detecting the presence of the single-nucleotide polymorphism rs12313273 (C/T) at position 30881 of the ORAI1 gene (SEQ ID No.: 1) in the biosample; and determining a... Agent: Kaohsiung Medical University
20120100544 - Method for quantifying dna in a biological sample: Improved methods of quantifying nucleic acids that are unique to a transgenic corn event designated Bt11 in a biological sample and compositions thereof are disclosed. The invention further relates to primer pairs used in the method that are unique to event Bt11.... Agent:
20120100537 - Method of prenatal molecular diagnosis of down syndrome and other trisomic disorders: The present invention encompasses a method of diagnosing chromosomal trisomy in a human subject. In one embodiment, the method comprises pyrosequencing at least one single nucleotide polymorphism on a chromosome being assessed for trisomy, where the SNP comprises two alleles.... Agent: Yale University
20120100535 - Methods for quantitative determination of methylation density in a dna locus: The present invention is a novel method of determining the average DNA methylation density of a locus of interest within a population of DNA fragments.... Agent: Orion Genomics LLC
20120100540 - Ultra sensitive method for in situ detection of nucleic acids: Disclosed is a method for in situ detection of one or more target nucleic acids based on a combination of RNAscope® method and a general ISH signal amplification method. This new method produces high signal intensity and while keeps low background noise of signal amplification. The result can be consistently... Agent: Advanced Cell Diagnostics, Inc.
20120100553 - Cho/cert cell lines: The invention concerns the field of cell culture technology. The invention describes production host cell lines comprising vector constructs comprising a CERT S132 A expression cassette. Those cell lines have improved growth characteristics and high CERT S132A expression levels. The invention especially concerns two cell lines deposited with the DSMZ... Agent: Boehringer Ingelheim International Gmbh
20120100554 - Detecting cancer with anti-ccl25 and anti-ccr9 antibodies: Methods for detecting cancer in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a... Agent: Morehouse School Of Medicine
20120100548 - Method for determining copy number variations: The invention provides a method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical... Agent: Verinata Health, Inc.
20120100550 - Method for determining fatty acid synthesis pathway of microorganism, and pcr primer set for use in the method: Disclosed is a method for determining the fatty acid synthesis pathway of a microorganism. Specifically disclosed is a method for determining the fatty acid synthesis pathway of a microorganism, which is characterized by producing degenerate primers for a fatty acid synthesis-related enzyme gene and determining the presence or absence of... Agent: Nippon Suisan Kaisha, Ltd.
20120100552 - Microfluidic liquid heating method and apparatus: Systems and methods for avoiding problems due to over-pressurization in a closed microfluidic device when the contained fluid is heated, by providing a well-defined volume for expansion of the liquid contents during heating, such as in one embodiment filling the expansion volume with air, and in other embodiments, filling the... Agent:
20120100546 - Nmr systems and methods for the rapid detection of analytes: This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.... Agent: T2 Biosystems, Inc.
20120100551 - Nucleic acid amplification reaction device, substrate used for nucleic acid amplification reaction device, and nucleic acid amplification reaction method: Disclosed herein is a nucleic acid amplification reaction device including: a reaction area configured to serve as a reaction field of a nucleic acid amplification reaction; an irradiating unit configured to irradiate light to the reaction area; and a light detecting unit configured to detect the amount of reflected light,... Agent: Sony Corporation
20120100547 - Real time pcr through gigahertz or terahertz spectrometry: A method is provided for spectroscopic real-time detection of nucleic acid molecules, in particular polynucleotide sequences, in a PCR amplification (PCR=polymerase chain reaction). The PCR amplification process includes preparing the initial substances required for producing a PCR solution in a buffer, and the repeating PCR reaction steps of denaturing, primer... Agent:
20120100549 - Targeted genome amplification methods: The methods disclosed herein relate to methods and compositions for amplifying nucleic acid sequences, more specifically, from nucleic acid sequences of pathogens by targeted genome amplification. In certain embodiments, multiple primer pairs are employed that flank a target region and polymerization is conducted with a strand displacing enzyme.... Agent: Ibis Biosciences, Inc.
20120100555 - Synthesis and use of fluorophore-tagged antimalarials: This invention includes a fluorophore-tagged antimalarial represented by the following structural formula (1) or a salt thereof. This invention relates to the synthesis of fluorophore-tagged antimalarials and describes the synthesis of a fluorophore-tagged antimalarial. These fluorophore-tagged antimalarials can be used to image live cells to determine the location of the... Agent:
20120100556 - Functional expression of higher plant nitrate transporters in pichia pastoris: The present invention relates to a system for functional expression of higher plant nitrate transporter (Nrt) genes in Pichia pastoris, an in vivo nitrate uptake assay using these Pichia pastoris transformants and an assay for readily identifying successful transformants.... Agent: Pioneer Hi-bred International, Inc.
20120100557 - Sample preparation device and associated method: A sample preparation device and associated method is provided for preparing samples according to an assay protocol. A cell deposition module deposits a sample on each a plurality of assay devices supported by a support device. An epitope retrieval module deposits a reagent on each of the samples. Each of... Agent: Becton Dickinson And Company
20120100559 - Novel hydrophilic and lipophilic rhodamines for labelling and imaging: The invention relates to novel and improved photostable rhodamine dyes of the general structural formulae I or II and their uses as fluorescent markers, e.g. for immunostainings and spectroscopic and microscopic applications, in particular in conventional and stimulated emission depletion (STED) microscopy and fluorescence correlation spectroscopy. The partially deuterated analogues... Agent: Max-planck-gesellschaft Zur Foerderung Der Wissenschaften E.v.
20120100561 - A pkn3/rhoc macromolecular complex and methods of use therefor: Disclosed are compositions comprising and methods of using a novel macromolecular assembly comprising PKN3, PDK1 and RhoC (PPRC complex). The PPRC complex was shown to have kinase activity and was found in cells of high malignancy potential, such as particularly aggressive cancers. In some aspects, the invention provides methods for... Agent:
20120100560 - Device for capture, enumeration, and profiling of circulating tumor cells: Applications in nanomedicine, such as diagnostics and targeted therapeutics, rely on the detection and targeting of membrane biomarkers. The present invention, in one embodiment, utilizes quantitative profiling, spatial mapping, and multiplexing of cancer biomarkers using functionalized quantum dots. This approach provides highly selective targeting molecular markers for pancreatic cancer with... Agent: The Johns Hopkins University
20120100558 - Lung cancer diagnosis: Diagnosis of lung cancer in a subject before onset of symptoms is described herein (i.e., in a pre-diagnostic subject), by screening a biological fluid from the subject for the presence therein of autoantibodies that are specific for one or more pre-diagnostic lung cancer indicator proteins, including LAMR1, and optionally additionally... Agent:
20120100562 - Methods and compositions for modulating the wnt pathway: The invention provides methods and compositions for modulating the Wnt signaling pathway, in particular by interfering with binding of Dkk1 or SOST with LRP5 and/or LRP6.... Agent: Genentech, Inc.
20120100563 - Devices and formulations for detecting, screening and monitoring levels of certain constituents in bodily fluids and method: The device is made by applying a chromagen to the carrier substrate to create a chromagen-laden carrier member. Then, a selected reagent having a particular constituent-specific formulation is applied to the chromagen-laden member. The selected reagent then combines with the chromagen, thereby establishing the indicator formulation within the carrier substrate... Agent: Pop Test LLC
20120100565 - High pressure enzymatic digestion system for protein characterization: A method and system for obtaining samples for proteomic analysis that utilizes pressure and a preselected agent to obtain a processing sample in a significantly shorter period of time than prior art methods and which maintains the integrity of the processing sample through the preparatory process. In one embodiment of... Agent: Battelle Memorial Institute
20120100564 - Prediction of memapsin 2 cleavage sites: Aspartic proteases such as mempasin-2 are import enzymes, playing roles in a variety of diseases. The inventors have developed a model to predict the cleavage sites and preferences for memapsin 2 substrates.... Agent:
20120100566 - Chemiluminescent compositions, methods, assays and kits for oxidative enzymes: Chemiluminescent compositions, methods, assays and kits for oxidative enzymes are described. Further disclosed are dioxetane compounds of the form: 0-0 ΛR R R T (i) where R can independently be any branched alkyl or cycloalkyl group which provides stabilization for the dioxetane or where both R groups together form a... Agent: Life Technologies Corporation
20120100567 - Measurement method using oxidase: A method for measuring a target object in a sample by using an oxidase, wherein the influence of dissolved oxygen in the sample can be corrected, is provided. The method comprises: obtaining measurement values by causing the target object in the sample to react with the oxidase under different conditions... Agent: Arkray, Inc.
20120100568 - Serum-free medium for inducing pluripotent stem cells quickly with high efficiency and method using thereof: A serum-free medium for inducing and reprogramming somatic cells into induced pluripotent stem cells (iPS) quickly with high efficiency, and the method using thereof for inducing and reprogramming somatic cells without feeder are provided, wherein the rate and efficiency of whole process of inducing and reprogramming are greatly improved. The... Agent: Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
20120100570 - Site-specific incorporation of redox active amino acids into proteins: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active... Agent: The Scripps Research Institute
20120100569 - Supercharged proteins for cell penetration: Compositions, preparations, systems, and related methods for delivering a supercharged protein, or a complex of a supercharged protein and an agent (e.g., nucleic acids, peptides, proteins, small molecules) to cells are provided. Such systems and methods include the use of supercharged proteins. For example, superpositively charged proteins may be associated... Agent:
20120100572 - Bioprocessing: Bioreactors are provided that include a vessel and a jet mixer disposed in the vessel. Methods that utilize the bioreactors are provided, involving placing a microorganism or cells and a fluid medium in the bioreactor.... Agent: Xyleco, Inc.
20120100571 - Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon: Biocompatible composites comprising peptide amphiphiles and surface modified substrates and related methods for attachment thereon.... Agent: Northwestern University
20120100573 - Cytomegalovirus intron a fragments: Cytomegalovirus (CMV) Intron A fragments for expressing gene products are disclosed. Also described are expression vectors including the fragments, as well as methods of using the same.... Agent:
20120100574 - Flavivirus-based system for production of hepatitis c virus (hcv): Provided herein is a mammalian cell transformed to contain a plasmid encoding a T7 or SP6 promoter operably linked to one or more HCV genes, a subgenomic replicon from a flavivirus and a cytoplasmic T7 and SP6 RNA amplification system. Also provided herein are isolated replication-competent HCV particles produced by... Agent:
20120100575 - Antibodies having altered effector function and methods for making the same: The invention provides a method of producing aglycosylated Fc-containing polypeptides, such as antibodies, having desired effector function. The invention also provides aglycosylated antibodies produced according to the method as well as methods of using such antibodies as therapeutics.... Agent: Biogen Idec Ma Inc.
20120100576 - Perfusion bioreactor: The present invention pertains to a system for culturing cells comprising a culturing bag and a continuous flow centrifuge wherein the cells are continuously separated from the supernatant and are recycled into the culturing bag. Further provided are methods for culturing cells and for producing a biological substance using the... Agent: Glycotope Gmbh
20120100578 - Cellulase preparation comprising endoglucanases derived from two different types of microorganisms: By having a cellulase preparation comprising at least a certain amount of endoglucanases derived from two different types of microorganisms, the cellulase preparation can be provided with a higher activity and a wider pH property than those of cellulase preparations each containing one of the endoglucanases alone. Moreover, by introducing... Agent: Meiji Seika Pharma Co., Ltd.
20120100577 - Processing biomass: Methods of manufacturing fuels are provided. These methods use often difficult to process lignocellulosic materials, for example crop residues and grasses. The methods can be readily practiced on a commercial scale in an economically viable manner, in some cases using as feedstocks materials that would otherwise be discarded as waste.... Agent: Xyleco, Inc.
20120100579 - Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer: A triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R1 represents an aromatic group having as a substituent or as a part of a substituent at least... Agent: Tokyo University Of Agriclature And Technology Tlo Co., Ltd.
20120100580 - Method for producing phospholipid: Provided is a method for producing a phospholipid at low cost by reusing phospholipase A2 in a method for producing the phospholipid whereby an arbitrary fatty acid is bonded to the 2-position of a phospholipid using an esterification reaction catalyzed by phospholipase A2 in glycerol. The method for producing a... Agent:
20120100581 - Phospholipases, nucleic acids encoding them and methods for making and using them: The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, phosphatidic acid phosphatases (PAP)) and/or lipid acyl hydrolase (LAH) activity, nucleic acids encoding them and antibodies that bind to them. Industrial methods, e.g., oil degumming, and products comprising use of these... Agent: Verenium Corporation
20120100582 - Pig liver esterases: The invention relates to an isolated polypeptide having esterase activity comprising an amino acid sequence shown in any one of SEQ ID NO's 2, 4, 6, 8, 10, 12 or 14 or a homologue thereof, comprising an amino acid substitution or deletion of one or more amino acids as shown... Agent:
20120100584 - 2-deoxy-scyllo-inosose synthase: e
20120100583 - Enzymatic synthesis of polymers: The invention relates to new methods of enzymatic synthesis of polymers such as polyorganosilicones and polyesters, and new polymers made by these methods.... Agent: University Of Massachusetts
20120100586 - Bioprocessing: Functionalized substrate materials, for example inorganic particles and/or synthetic polymeric particles, are used to enhance bioprocesses such as saccharification and fermentation.... Agent: Xyleco, Inc.
20120100587 - Bgl7 beta-glucosidase and nucleic acids encoding the same: The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same.... Agent:
20120100588 - Efficient oil shale recovery method: A method for recovering hydrocarbons from oil shale and other carbonaceous materials has the steps of preparing a biomedium of microorganisms, water, and nutrients; providing shale laden with oil; treating oil shale with the biomedium; mechanically agitating the treated oil shale and biomedium approximately twelve hours to form a liquid... Agent:
20120100589 - Method for methane generation: A method for treatment of a material comprising lignocellulosic fibres is disclosed. More particularly, the treatment increases the accessibility of the lignocellulosic fibres for following microbial or biological processes.... Agent: Novozymes A/s
20120100590 - Microbially-assisted water electrolysis for improving biomethane production: A method of producing in a bioreactor a biogas rich in methane involves electrolyzing water in an aqueous medium at a voltage in a range of from 1.8 V to 12 V in the presence of electrochemically active anaerobic microorganisms that biocatalyze production of hydrogen gas, and, contacting a species... Agent:
20120100591 - Process for producing fermentation products and fermentation medium compositions therefor: Fermentation products (e.g., bioproducts such as hydrocarbons and other organic compounds) are produced from biomass or gases through digestion and fermentation under conditions that thermodynamically favor production of the fermentation products.... Agent:
20120100592 - Pipemidic acid derivative autotaxin inhibitors: Novel and optimized classes of pipemidic acid derivative compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes of compounds exhibit exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can... Agent:
20120100593 - Crystals of membrane proteins: A polypeptide in crystalline form comprises a G-protein coupled receptor (GPCR) with an IC3 loop substituted by an amino acid residue sequence of lysozyme.... Agent: The Scripps Research Institute
20120100595 - Delta-9 elongases and their use in making polyunsaturated fatty acids: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) and using these delta-9 elongases in plants.... Agent:
20120100594 - Enzyme catalysts for diels-alder reactions: The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other aspects, the invention provides methods of making the enzyme catalysts, including by de novo computational design. The present invention thereby provides enzyme catalysts capable of... Agent: University Of Washington
20120100596 - Dfpase enzymes from octopus vulgaris: The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s
20120100597 - Stabilized protease-containing solutions: The present invention provides compositions and methods for purifying RNA-free DNA from a sample.... Agent: Bio-ras Laboratories, Inc.
20120100598 - R. rhodochrous and linoleic acid as bioremediation agents of polycyclic aromatic hydrocarbons (pah) in diesel-contaminated soil: Different bioremediation agents' effectiveness against concentrations of diesel fuel in soil were tested. The purpose of this experiment is to find a quick, clean, and cost-effective alternative to current remediation techniques using new bioremediation techniques. Analysis indicated that the use of a mixture of Linoleic acid and R. rhodochrous generated... Agent:
20120100599 - Nucleic acid isolation using polidocanol and derivatives: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to... Agent: Roche Molecular Systems, Inc.
20120100600 - Apparatus for polynucleotide detection and quantitation: An apparatus for expression profiling analysis, subjecting biological materials to polynucleotide extraction, amplification and analysis. The apparatus include an amplification device which permits the amplification of polynucleotides and an analysis device which quantifies the amount of the amplified polynucleotide products. The amplification device of the apparatus may further permit polynucleotide... Agent: Primeradx, Inc.
20120100601 - Analyte measurement devices and systems, and components and methods related thereto: In some aspects, a modular analyte measurement system having a replaceable strip port module is provided to permit contaminated modules to be replaced. Some aspects of the present disclosure related to barriers for strip ports or the sealing of strip ports and/or analyte measurement devices to maintain a clean strip... Agent: Abbott Diabetes Care Inc.
20120100602 - Bioreactor system for mechanical stimulation of biological samples: The subject application provides an apparatus for applying mechanical loading to a biological sample, said apparatus comprising: a bioreactor device configured to house the biological sample, and a load application unit for applying mechanical loading to the biological sample housed in the bioreactor device, said load application unit including: a)... Agent:
20120100603 - Photobioreactor systems and methods for treating co2-enriched gas and producing biomass: Certain embodiments and aspects of the invention relate to a photobioreactor including covered photobioreactor units through which a liquid medium stream and a gas stream flow. The liquid medium comprises at least one species of phototrophic organism therein. Certain methods of using the photobioreactor system as part of fuel generation... Agent:
20120100605 - Device for cultivating cells and/or microorganisms: A reactor is designed as a disposable element, a container receives the reactor, and a device comprises a reactor. A drive unit of the device generates a rotating-oscillating motion of the reactor, and the device is utilized for cultivating cells and/or microorganisms.... Agent: Bayer Technology Services Gmbh
20120100604 - Methods and compositions for generating self attenuating genetic circuitry: The invention provides compositions and methods for engineering self-attenuating circuitry in a cell that provides an optimal homeostasis between TGF-β/pSmad and Notch signaling to produce the long-term restoration of tissue regenerative potential and repair.... Agent: The Regents Of The University Of California
20120100606 - Inducible system for highly efficient production of recombinant adeno-associated virus (raav) vectors: Production of clinical grade gene therapy vectors for human trials remains a major hurdle in advancing cures for a number of otherwise incurable diseases. Disclosed herein are systems based on a stably trans formed insect cell lines harboring helper genes required for vector production. Specifically exemplified are system embodiments that... Agent:
20120100607 - Compositions of adult disc stem cells and methods for the treatment of degenerative disc disease: This invention provides a tissue growth apparatus comprising one or more discospheres and a method of producing nucleus pulposus cells comprising the step of growing one or more discospheres on the tissue growth apparatus. This invention also provides a neo-engineered disc comprising nucleus pulposus cells, and related methods of production... Agent:
20120100608 - Lymphocreme: The mixture is a topical crème for use in the treatment of cutaneous T-cell Lymphoma.... Agent:
20120100609 - N-linked glycan biosynthesis modulators: Provided herein are N-linked glycan inhibitors, including modulators of N-linked glycan glycosylation, mannosidase, an N-linked glycan N-acetylglucosaminyl transferase, an N-linked glycan fucosyl transferase, an N-linked glycan galactosyl transferase, an N-linked glycan sialyl transferase, an N-linked glycan sulfotransferase, N-linked glycan glycophosphotransferase or a combination thereof.... Agent:
20120100610 - Revascularization cells derived from mononuclear cells, and method of inducing differentiation thereof: The present invention relates to a method of safely and simply inducing differentiation of mononuclear cells into cells that promote neovascular stabilization and maturation, and lead to recovering from ischemia or tissue repair. The cells according to the present invention are obtained by inducing differentiation of a mononuclear cell by... Agent: National University Corporation Asahikawa Medical
20120100611 - Procedure and device for separating adult stem cells from fatty tissue: The invention relates to a method for separating adult stem cells from fatty tissue, wherein the fatty tissue is mixed with a fluid and the stem cells are subsequently separated. The fatty tissue with fat cells and adult stem cells is exposed to a fluid jet (38) having a pressure... Agent: Human Med Ag
20120100612 - Culture substrate, culture sheet, and cell culture method: Disclosed is a culture sheet which enables technology in which three-dimensional tissues with uniform diameter are formed without applying chemicals to the surface of a culture substrate. A plurality of holes are formed on the culture sheet of the substrate, and nanopillars capable of controlling the adhesiveness or migration of... Agent: Hitachi, Ltd.
20120100613 - Compositions and methods for the modulation of gene expression in plants: Compositions and methods for modulating nucleotide sequence expression, particularly for modulating gene expression in plants, are provided. The compositions comprise precursor RNA constructs for the expression of an RNA precursor. The precursor RNA construct comprises a promoter that is expressed in a plant cell driving the expression of a precursor... Agent: University Of South Carolina
20120100615 - Cell fate conversion of differentiated somatic cells into glial cells: The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from this reprogramming are functionally equivalent to glial cells that arise from ectodermal origins.... Agent: Case Western Reserve University
20120100614 - Method for production of anti-tumor trail protein: The method for production of anti-tumor TRAIL comprises: inserting a TRAIL molecule, encoded by a viral vector irreversibly derived from a cell line, into a carrier cell, thereby obtaining a stably TRAIL-producing carrier cell, said TRAIL molecule comprising a soluble molecule.... Agent:
20120100616 - Method of double crossover homologous recombination in clostridia: The invention relates to a method of double crossover homologous recombination in a host Clostridia cell comprising: a first homologous recombination event between a donor DNA molecule and DNA of the host cell to form a product of the first recombination event in the host cell, wherein the donor DNA... Agent: The University Of Nottingham
20120100617 - Pichia pastoris loci encoding enzymes in the adenine biosynthetic pathway: Disclosed are the ADE3, ADE4, ADE5, 7, ADE6, ADE8, ADE12, and ADE13 genes encoding various enzymes in the adenine biosynthesis pathway of Pichia pastoris. The loci in the Pichia pastoris genome encoding these enzymes are useful sites for stable integration of heterologous nucleic acid molecules into the Pichia pastoris genome.... Agent:
20120100621 - Pichia pastoris loci encoding enzymes in the arginine biosynthetic pathway: Disclosed are the ARG5, 6, ARG8, ARG9, ARG80, ARG81, and ARG82 genes encoding various enzymes in the arginine biosynthesis pathway of Pichia pastoris. The loci in the Pichia pastoris genome encoding these enzymes are useful sites for stable integration of heterologous nucleic acid molecules into the Pichia pastoris genome. The... Agent:
20120100618 - Pichia pastoris loci encoding enzymes in the histidine biosynthetic pathway: Disclosed is the HIS7 gene encoding the His7p enzyme in the histidine biosynthesis pathway of Pichia pastoris. The locus in the Pichia pastoris genome encoding the His7p is useful sites for stable integration of heterologous nucleic acid molecules into the Pichia pastoris genome. The gene or gene fragment encoding the... Agent:
20120100620 - Pichia pastoris loci encoding enzymes in the lysine biosynthetic pathway: Disclosed are the LYS1, LYS2, LYS4, LYS5, and LYS9 genes encoding various enzymes in the lysine biosynthesis pathway of Pichia pastoris. The loci in the Pichia pastoris genome encoding these enzymes are useful sites for stable integration of heterologous nucleic acid molecules into the Pichia pastoris genome. The genes or... Agent:
20120100619 - Pichia pastoris loci encoding enzymes in the methionine biosynthetic pathway: Disclosed are the MET1, MET3, MET4, MET6, MET7, MET8, MET10, MET14, MET16, MET17, MET19, MET22, MET2, and MET28 genes encoding various enzymes in the methionine biosynthesis pathway of Pichia pastoris. The loci in the Pichia pastoris genome encoding these enzymes are useful sites for stable integration of heterologous nucleic acid... Agent:
20120100622 - Pichia pastoris loci encoding enzymes in the uracil biosynthetic pathway: Disclosed are the URA1, URA2, URA4, and URA6 genes encoding various enzymes in the uracil biosynthesis pathway of Pichia pastoris. The loci in the Pichia pastoris genome encoding these enzymes are useful sites for stable integration of heterologous nucleic acid molecules into the Pichia pastoris genome. The genes or gene... Agent:04/19/2012 > 119 patent applications in 68 patent subcategories.
20120094268 - Tissue maintenance: The invention provides a method of reducing damage to a tissue, organ or cell from surgical procedures comprising administering a composition comprising a potassium channel opener/agonist and/or an adenosine receptor agonist (eg. adenosine) together with a local anaesthetic (eg. lignocaine) when perfusing the organ.... Agent: Hibernation Therapeutics Limited
20120094269 - Novel method for microbes depletion in human blood or full serum using antimicrobial photodynamic laser therapy: Treatment methods/devices are provided for attenuating/inactivating the pathogenic microbes found in biological fluids e.g. blood/blood products including human single-donor-fresh-frozen-plasma, platelet concentrate, red blood cells, blood clotting factors. An Antimicrobial Photodynamic Therapy method is used to eliminate multiple (resistant) bacteria, viral agents, fungi, parasites and other undetected or non-easily detected pathogenic... Agent:
20120094274 - Identification of swine-origin influenza a (h1n1) virus: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses (e.g., swine-origin influenza A (H1N1) virus) which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Ibis Biosciences, Inc.
20120094273 - Immunological method for detecting active jcv infection: The invention relates to an immunological method for detecting an extra renal active infection by JC virus in a patient candidate for a treatment with an immunosuppressive treatment or during the course of this treatment.... Agent: Assistance Publique - Hopitaux De Paris
20120094276 - Methods and devices to enhance sensitivity and evaluate sample adequacy and reagent reactivity in rapid lateral flow immunoassays: Methods and devices for rapid lateral flow immunoassays to detect specific antibodies within a liquid sample while also validating the adequacy of the liquid sample for the presence of immunoglobulin and the integrity and immunoreactivity of the test reagents that detect the antibodies of interest, without requiring instrumentation. The methods... Agent:
20120094275 - Methods and kits for the detection of circulating tumor cells in pancreatic patients using polyspecific capture and cocktail detection reagents: A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric or image cytometry to detect, enumerate and characterize carcinoma cells in the blood. The present invention incorporates the conjugation of different antibodies to the same ferrofluid. This has the effect of making the ferrofluid polyspecific with... Agent:
20120094277 - Methods of producing competitive aptamer fret reagents and assays: Methods are described for the production and use of fluorescence resonance energy transfer (FRET)-based competitive displacement aptamer assay formats. The assay schemes involve FRET in which the analyte (target) is quencher (Q)-labeled and previously bound by a fluorophore (F)-labeled aptamer such that when unlabeled analyte is added to the system... Agent: Pronucleotein Biotechnologies, LLC
20120094271 - Selecting for cooperatively interacting molecules: The present invention provides method of identifying molecules that cooperatively and positively interact with either a ligand or a target molecule of a ligand/target molecule pair, or molecules that interact with a ligand/target molecule complex.... Agent: Arizona Board Of Regents For And On Behalf Of Arizona State University
20120094270 - Self-exciting, self-sensing piezoelectric cantilever sensor for detection of airborne analytes directly in air: A method for detection of airborne biological agent using a piezoelectric cantilever sensor that includes a piezoelectric layer and a non-piezoelectric layer. A recognition entity is placed on one or both of the two layers. The antibody that recognizes and binds to the airborne species may be chemically immobilized on... Agent:
20120094272 - Signal enhancement system with multiple labeled-moieties: Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labelled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal... Agent: Diagnostics For The Real World, Ltd.
20120094281 - Articles with shell structures including a cell extractant and biodetection methods thereof: Articles are provided for the detection of cells in a sample. The articles include a release element comprising a cell extractant. The release element includes a shell structure that controls the release of the cell extractant into a liquid mixture containing the sample. Methods of use are also disclosed.... Agent:
20120094280 - Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases: The present invention relates to a use of non-cofactor compounds, represented by formulas (I) or (II) wherein R and Z are independently selected from H, D, C1-C12-alkyl, preferably C1-C4-alkyl, alkenyl, alkinyl, phenyl or -LX, wherein X represents a functional group or a reporter group attached via a linker group L,... Agent: Biotechnologijos Institutas
20120094282 - Method for detecting g-quadruplex, method for detecting g-quadruplex-forming dna and method for determining telomerase activity: A method is provided for specifically detecting a G-quadruplex, and the like. The method is characterized by including the steps of preparing a solution including an anionic planar phthalocyanine and mixing the solution with a sample solution to obtain a liquid mixture. The solution includes an anionic planar phthalocyanine. The... Agent: Panasonic Corporation
20120094278 - Methods and apparatus for characterizing polynucleotides: Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase, adjacent the nanopore aperture.... Agent:
20120094279 - Use of enzymes for altering ratios of partially matched polynucleotides: The present disclosure relates to novel methods of discriminating and/or detecting mis-matched polynucleotide populations in a sample by determining the ratios of mismatched polynucleotide species after specific enzymatic digestion treatment. Aspects of this disclosure includes obtaining, enhancing and/or determining the amount of one DNA or RNA species versus another in... Agent:
20120094283 - Ace2 as a target gene for the molecular identification of yeast and fungal species: The present invention relates to nucleic acid primers and probes for use in the identification of one or more yeast species. More specifically the invention relates to the Ace2 gene, the corresponding RNA, specific probes, primers and oligonucleotides related thereto and their use in diagnostic assays to detect and/or discriminate... Agent: National University Of Ireland, Galway
20120094288 - Assay for determining epigenetic profiles of markers of fragile x alleles: The present invention relates generally to an assay for the determination of epigenetic profiles, particularly epigenetic profiles associated with a pathological condition. Even more particularly, the present invention provides an assay to detect epigenetic profiles within the Fragile X Mental Retardation (FMR) genetic locus indicative of a pathoneurological condition such... Agent: Murdoch Childrens Research Institute
20120094290 - Epigenetic marker for the identification of natural killer cells: The present invention relates to a method, in particular an in vitro method for identifying natural killer cells of a mammal, which often express the surface proteins CD 16 and/or CD56, comprising analysing the methylation status of at least one CpG position in the CX3CR1 and/or FGR and/or NKG7 and/or... Agent: Epiontis Gmbh
20120094291 - Fcgamma polymorphisms for predicting disease and treatment outcome: The invention provides compositions and methods for determining the likelihood of successful treatment with Cetuximab or other equivalent. The methods comprise determining the genomic polymorphism present in a predetermined region of the FcγRIIa gene at amino acid position 131 and/or alternatively the FcγRIIIa gene at amino acid position 158.... Agent: University Of Southern California
20120094292 - Forensic identification: The invention provides allelic ladder mixtures and individual alleles suitable for use in such mixtures. The allelic ladder mixtures give improved identification and distinguishing capabilities, particularly suitable in forensic investigations.... Agent: Forensic Science Service Ltd.
20120094286 - Gene dosage analysis: The present invention relates to methods of detecting the presence of a genetic polymorphism within two or more closely linked, homologous genes, for example α-thalassemia, in a sample using RT-PCR by subjecting the sample to separate amplification reactions using (a) a pair of forward and reverse primers specific for the... Agent: Kantonsspital Aarau Ag
20120094289 - Materials and methods for determining cancer risk: This document relates to materials and methods involved in assessing inflammatory bowel disease patients at risk for developing cancer. For example, materials and methods for monitoring colorectal cancer risk in ulcerative colitis patients are provided.... Agent:
20120094287 - Methods and compositions for detecting gastrointestinal and other cancers: This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.... Agent:
20120094293 - Pgc-1ß, a novel pgc-1 homologue and uses therefor: The invention provides isolated nucleic acid molecules, designated PGC-1β nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1β nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in... Agent: Dana-farber Cancer Institute, Inc.
20120094284 - Prediction of early virological response in hcv treatment: The present invention is based on the discovery of associations that exist between single nucleotide polymorphisms (SNPs) on chromosome 19 and virological outcomes in a diverse population of patients with hepatitis C virus (HCV) who received interferon-based treatment.... Agent: Roche Molecular Systems, Inc.
20120094285 - Ratiometric pre-rrna analysis: Disclosed are compositions and methods for detecting the presence of viable cells in a sample. Included are compositions and methods for increasing the sensitivity of a nucleic acid amplification test for determining the presence of at least one target microorganism in a sample. Also disclosed are compositions and methods for... Agent: University Of Washington
20120094300 - Bin1 as a prognostic marker in cardiovascular disease: The present disclosure provides methods involving use of BIN1 expression levels, in heart tissue, in evaluating the risk of a poor outcome in a patient diagnosed with congestive heart failure. The methods finds use in evaluating patients who are heart transplant candidates as well as in assessing therapy options and... Agent:
20120094294 - Bms1 protein expression system: e
20120094301 - Characterizing an allotypic phenotype of a subject: Methods, compositions, and kits relating to selecting a prophylactic or therapeutic antibody less likely to induce or aggravate an anti-antibody response in a subject administered the antibody. An antibody for administration to a subject may be selected to match, or at least more closely resemble, the allotypic phenotype of the... Agent: Xbiotech, Inc.
20120094296 - Enzyme preparation containing thermostable dna polymerase, method for producing same, and method for detecting subject organism to be detected: Disclosed is a thermostable DNA polymerase preparation which can illimitably reduce the risk of false positivity in the detection of a subject microorganism utilizing a gene amplification reaction and therefore enables the selective amplification of DNA for detecting the subject microorganism even when the amount of the subject microorganism is... Agent: Hokkaido Mitsui Chemicals Inc.
20120094302 - Marker for indentifying variety/line of plant of the genus saccharum and the use thereof: It is an object of the present invention to provide a method for identifying the variety/line of a plant of the genus Saccharum with the use of novel DNA markers that allow high-precision identification of a wide range of varieties/lines of plants of the genus Saccharum. A method for identifying... Agent: Toyota Jidosha Kabushiki Kaisha
20120094297 - Method for producing protein: The present invention relates to a recombinant host cell, wherein the cell is modified to increase the expression levels of Ero1 and XBP1 relative to the expression levels of Ero1 and XBP1 in an unmodified cell. The present invention also relates to a method of producing a recombinant protein of... Agent: Ucb Pharma S.a.
20120094295 - Neurodegenerative disease diagnostic compositions and methods of use: The invention generally provides diagnostics that employ biomarkers altered in neurodegenerative disease, as well as methods for the use of such markers in monitoring disease progression and identifying agents useful for the treatment of a neurodegenerative disease.... Agent: The Johns Hopkins University
20120094298 - Nucleic acid amplification with integrated multiplex detection: A method mediated with in-vitro transcription (“IVT”) which permits miniaturization of multiplexed DNA and RNA analysis, and in which elongation-mediated multiplexed analysis of polymorphisms (eMAP®) is used as the analysis step, is described. Also described is a method mediated with IVT is for selecting a designated strand from T7-tagged double... Agent: Bioarray Solutions Limited
20120094299 - Nucleotide repeat expansion-associated polypeptides and uses thereof: Isolated polypeptides that are endogenously expressed from nucleotide repeat expansions are disclosed. In some cases, the polypeptides include polypeptide repeats. In some cases, the polypeptide repeats include at least five contiguous repeats of a single amino acid. In other cases, the repeats include at least six contiguous amino acids of... Agent: Regents Of The University Of Minnesota
20120094303 - Device for assaying analytes in bodily fluids: A device for determining the presence and/or quantity of one or more analytes in a sample of human body fluid has a container for receiving a sample of body fluid, with an interior that is delimited by a base and by a circumferential surface. It further comprises at least one... Agent: Ulti Med Products International Gmbh
20120094304 - Method of preparing human lung tissue stem cells and method of inducing differentiation into human alveolar epithelial cells: Provided are: a method of preparing cells that simultaneously express a type II alveolar epithelial cell marker and a stem cell marker, including a process of isolating and extracting constituent cells from human lung tissue, and a process of separating and culturing lung tissue stem cells from the obtained isolated... Agent: Tohoku University
20120094305 - Methods for treating and diagnosing fibrotic and fibroproliferative diseases: The present invention provides compositions and methods for diagnosing and treating fibrotic lung disease. In one embodiment the diagnostic method comprises determining the amount of circulating CXCL-12 in a patient relative to a control.... Agent: University Of Virginia Patent Foundation
20120094306 - Predictive evaluation of the response to taxane-including chemotherapy: The present invention relates to methods and kits for a predictive evaluation of the effectiveness of a taxane-including treatment of a tumour or of cancer cells.... Agent: Universita Cattolica Del Sacro Cuore
20120094310 - Method for determining biologically active hgf: The present invention relates to a for determining the presence, absence or amount of biologically active or inactive HGF in a sample, comprising the steps: bringing the sample in contact with a gel comprising a HGF binding component of the extracellular matrix or cell membrane, adding toluidine blue to the... Agent:
20120094311 - Gene and protein expression profiles associated with the therapeutic efficacy of egfr-tk inhibitors: The present invention provides protein and gene expression profiles indicative of whether a patient afflicted with non-small cell lung cancer is likely to be responsive to treatment with a therapeutic compound that is a EGFR-TK inhibitor. By identifying such responsiveness, a treatment provider may determine in advance those patients who... Agent:
20120094312 - Boosting human dendritic cell development, homeostasis and function in xenografted immunodeficient mice: The present invention relates to a transgenic animal mode system based on the development of transgenic mice bearing components of the human immune system. Specifically, the Invention relates to a Flk2 deficient Rag “γc” transgenic mouse and the engraftment of said mouse with human hematopoietic stem cells. The present invention... Agent: Inserm (institut National De La Sante Et De La Rec Herche)
20120094307 - Tube for measuring bio-related substance and quantifying system: A bio-related substance assay tube 2 comprises a target substance capture bead 3 serving as a first microparticle, compensation bead 4 serving as a second microparticle on which a given amount of a bio-related substance has been immobilized, and a negative control bead 5 serving as a third microparticle for... Agent: Universal Bio Research Co., Ltd.
20120094308 - Kit and method for the premortem in vitro detection of alzheimer's disease: Kit and method for the pre mortem in vitro detection of Alzheimer's disease The invention relates to a detection kit for Alzheimer's disease based on the vitro identification of the presence of biomarkers in the remains normally discarded after crystalline lens surgery. The kit can be used for the pre... Agent: Universidad Complutense De Madrid
20120094313 - Nonseparation assay methods: Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support as is a member of a specific binding pair for capturing an analyte from a sample. An activator compound that activates the chemiluminescent... Agent: Beckman Coulter, Inc.
20120094309 - Non-proteolytic method for the determination of analytes in keratinized structures: Methods that permit the rapid release of one or more analytes from head or body hair or other keratinized structures of an individual (who may previously have ingested one or more of the analytes) are provided. The methods can include contacting the keratinized structure with a reducing agent but not... Agent: Psychemedics Corporation
20120094315 - Biomarkers for the diagnosis and/or prediction of susceptibility to mental and neurodegenerative disorders: Provided herein are, inter alia, methods for predicting the susceptibility of a subject to a mental or neurodegenerative disorder, the method comprising obtaining one or more biological samples from the subject; determining the levels of one or more biomarkers in the sample, wherein the biomarkers are selected from pyrroles, histamine,... Agent:
20120094314 - Diagnosis of septic complications: The invention describes a method for diagnosing of septic complications in polytraumatised human or animal patients, said patients being free of traumatic brain injury, by determining the level of the C-type natriuretic peptide (CNP), its precursors or fragments thereof, especially the precursor of the C-type natriuretic peptide (NT-proCNP), in this... Agent:
20120094316 - Drug detection: The invention relates to an immunoassay method and kit for the detection and/or the determination of mephedrone, mephedrone metabolites and related compounds. The invention is underpinned by a novel antibody, derived from a novel immunogen, that is sensitive and binds to mephedrone, mephedrone metabolites and related compounds.... Agent:
20120094318 - E-cadherin as a biomarker of gastroesophageal reflux disease: The present invention provides methods of diagnosing and identifying subjects as having GERD comprising detecting E-cadherin fragments in a biological sample from the subject. The invention further provides methods for identifying subjects as having heartburn that is responsive to proton pump inhibitor therapy and subjects having an increased likelihood of... Agent: The University Of North Carolina At Chapel Hill
20120094317 - Method and apparatus for detecting an analyte: In one aspect, this disclosure provides a substrate for determining the concentration of an analyte within a sample. The substrate includes a conductive region and a recognition layer, the conductive region including at least one particle and having a first surface operatively coupled with the recognition layer, the recognition layer... Agent: Imec
20120094319 - Method of dispensing biosensors: A storage cartridge for dispensing biosensors used in the determination of an analyte in body fluid comprises a hollow body for housing a stack of biosensors having an open top, a flexible conveying member disposed over the open top of the body, the flexible conveying member having an aperture formed... Agent: Bayer Healthcare LLC.
20120094321 - Method and kit for measurement of dehydrogenase or substrate for the dehydrogenase: Disclosed is a method for measuring a dehydrogenase or a substrate for the dehydrogenase contained in a sample, wherein both thio-NAD or thio-NADP and NAD or NADP are used as coenzymes. The method enables the measurement on the basis of absorbance values obtained in a visible region, and also enables... Agent:
20120094320 - Thermostable 1,5-anhydroglucitol dehydrogenase, and method for measurement of 1,5-anhydroglucitol by using the same: A protein comprising an amino acid sequence having at least one mutation selected from a Gly-4 to Ala mutation, a Glu-6 to His mutation, a Ser-14 to Thr mutation, an Ala-37 to Thr or Arg mutation, a Pro-50 to Gln mutation, a Glu-67 to Gly mutation, an Asp-80 to Tyr... Agent: Nippon Kayaku Kabushiki Kaisha
20120094322 - Device for diagnosis of physiologic status and/or selection of the best spermatozoa of a semen sample based on chemotaxis, and procedure of use thereof: A device for diagnosis of physiologic status and/or selection of best spermatozoa of a semen sample based on chemotaxis, and the procedure of thereof, enabling by a simple and inexpensive device the diagnosis and selection of the best spermatozoa in only one step. Only needed are: the present device, a... Agent: Inis Biotech LLC
20120094323 - Cardiomyocytes-containing device and method for manufacturing and using the same: Disclosed is a device for determining the cardiotoxicity of a chemical compound, comprising a substrate (10) carrying a deformable stack (34), said stack being partially detached from the substrate by a cavity (32) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer (16), a second... Agent: Koninklijke Philips Electronics N.v.
20120094326 - Imaging and evaluating embryos, oocytes, and stem cells: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most... Agent: The Board Of Trustees Of The Leland Standford Junior Univeristy
20120094325 - Microfluidic cell motility assay: Certain isolated motile cells spontaneously migrate unidirectionally through a mechanically confined space, such as a microcapillary channel, in the absence of an external gradient (e.g., a chemical gradient). Assays and methods for detecting motile cells, and identifying chemical agents that inhibit cell migration, can include detecting the movement of motile... Agent: The General Hosptial Corporation
20120094324 - System and method for high throughput cell analysis and sorting: A sorting methodology in which bulk analysis of samples that have a low probability of containing a rare particle is performed first. Only those samples in which the bulk analysis has detected one or more rare particles are subjected to a flow cytometry process to isolate the rare particle(s). In... Agent:
20120094327 - Detection of acid-producing bacteria: The disclosure provides culture devices and methods useful for detecting acid-producing bacteria in a sample. The devices include a nutrient medium and a pH indicator to detect and differentiate acid-producing microorganisms, such as lactic acid bacteria. Methods of use include detecting or enumerating acid-producing microorganisms. The methods further provide for... Agent:
20120094328 - Fermentation product of cereal plant-derived material and immunomodulator: The present invention provides dendritic cells (DCs) having reduced inflammatory activity, a method for producing DCs capable of inducing regulatory T cells and regulatory T cells, and substances useful for such a method, wherein the DCs and regulatory T cells are useful for prevention and treatment of immune diseases. The... Agent: Kirin Holdings Kabushkik Kaisha
20120094329 - Increasing protein production by increasing abc50 expression or activity: The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell. ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of... Agent: University Health Network
20120094331 - Method for the preparation of carbohydrate cleavage products from a lignocellulosic material: A method for the preparation of carbohydrate cleavage products, characterized by the combination of the measures that the lignocellulosic material is treated with an aqueous solution containing hydrogen peroxide, an alcohol, in particular a C1-4 alcohol or a phenol, and a base in order to oxidatively break down lignocellulose and... Agent: Annikki Gmbh
20120094332 - Dna polymerases and mutants thereof: The present invention provides polypeptides having a nucleotide polymerase activity and method of enhancing polymerase activity. The polypeptides of the present invention may possess both a DNA-dependent DNA polymerase activity and an RNA-dependent DNA polymerase activity, i.e., a reverse transcriptase activity. The polypeptides of the present invention may be used... Agent: Life Technologies Corporation
20120094333 - Starch process: The present invention relates to a process for enzymatic hydrolysis of granular starch into a soluble starch hydrolysate at a temperature below the initial gelatinization temperature of said granular starch.... Agent: Novozymes A/s
20120094334 - bioreactor and method for producing microbial cellulose: A technique for producing microbial cellulose is provided, including: preparing a liquid medium for microbial cultivation in a container; horizontally rotating multiple hollow tubes that are fitted together or separated from one another, so that each of the hollow tubes is alternately partially immersed in the liquid medium and partially... Agent: Food Industry Research And Development Institute
20120094335 - Archael laccases and multicopper oxidases (mcos) and their uses thereof: The subject invention pertains to a novel purified polypeptide having laccase activity and the nucleic acid sequences encoding the polypeptide. The disclosed polypeptide works at moderately high temperatures from below 20° C. to about 70° C., both acidic and alkaline pH conditions, high salt concentrations and in the presence of... Agent: University Of Florida Research Foundation,inc.
20120094336 - Synthesis of equol: Subject of the invention is a method for the production of isoflavanes from isoflavones, whereby in a first reaction step (a) the 4-keto group of the isoflavone is reduced in a enantioselective manner, whilst the 2,3-double bond is maintained, to the 4-hydroxy compound.... Agent:
20120094337 - Process for producing a purified synthesis gas stream: The invention provides a process for producing a purified synthesis gas stream from a feed synthesis gas stream comprising contacting it with a water gas shift catalyst in a shift reactor to obtain a shifted synthesis gas stream enriched in H2S and in CO2. H2S and CO2 are removed from... Agent:
20120094338 - Continuous production and excretion of waxy products from photosynthetic organisms: This invention disclosed herein relates generally to production and maintenance of genetically modified organisms that are capable of continuously making and excreting valuable waxy products.... Agent:
20120094340 - Production of ester-based fuels such as biodiesel from renewable starting materials: Production of ester-based fuels such as biodiesel or jet fuel from renewable starting materials such as lignocellulosic material or algae is disclosed. Pulping and saccharification of the renewable starting materials produces carboxylic acids such as fatty acids or rosin acids, which are esterified via a gas sparged, slurry form of... Agent:
20120094342 - Enzymatic peracid production using a cosolvent: Disclosed herein are two-component enzymatic peracid generation systems and methods of using such systems wherein the first component comprises a formulation of at least one enzyme catalyst having perhydrolysis activity, a carboxylic acid ester substrate, and a cosolvent and wherein the second component comprises a source of peroxygen in water.... Agent:
20120094341 - Methods for the synthesis of olefins and derivatives: The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method... Agent: Genomatica, Inc.
20120094343 - Gene knockout mesophilic and thermophilic organisms, and methods of use thereof: One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt... Agent: Mascoma Corporation
20120094344 - Method for producing glycolic acid: Provided is a production method of glycolic acid having a first step of preparing glycolonitrile from formaldehyde and hydrocyanic acid and a second step of hydrolyzing the glycolonitrile into glycolic acid directly or via a glycolate salt, which method can produce glycolic acid in easy production and purification steps while... Agent:
20120094345 - Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors: The invention provides a non-naturally occurring microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (1,4-BDO) biosynthetic pathways. The pathways include exogenous nucleic acids encoding a) an α-ketoglutarate decarboxylase; b) a 4-hydroxybutanoate dehydrogenase; c) a 4-hydroxybutyryl-CoA:acetyl-CoA transferase or a butyrate kinase and a phosphotransbutyrylase; d) an aldehyde dehydrogenase, and e) an... Agent: Genomatica, Inc.
20120094346 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing in a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor... Agent: Ineos Bio Limited
20120094347 - Methods and compositions for degrading pectin: The present invention provides enriched polynucleotides, and enriched polypeptides having pectinase activity. The present invention also includes methods of using the polynucleotides and polypeptides described herein. For instance, the methods include producing a metabolic product, such as ethanol.... Agent: University Of Georgia Research Foundation, Inc.
20120094349 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing in a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor... Agent: Ineos Bio Limited
20120094348 - Organosolv biorefining of whole sugar cane: An apparatus for processing sugar cane to concurrently produce sugar from cane juice, and ethanol and other co-products from bagasse. The apparatus comprises equipment for separating a cane juice stream and a fibrous bagasse from a sugar cane feed-stock, equipment for refining the cane juice, equipment for processing the fibrous... Agent:
20120094351 - Methanization method from a liquid phase which is a coproduct resulting from the extraction of a main product obtained from a vegetable raw material: The invention relates to a methanization method from a liquid phase which is a coproduct resulting from the extraction of a main product obtained from a vegetable raw material, wherein the weight content of the suspended material (MES) in said liquid phase is lower than 0.25%, and the methanization processing... Agent: Ondeo Industrial Soulutions
20120094350 - Process for producing methane from biomass: The invention pertains to a process for producing methane by a two-stage anaerobic digestion of organic feed, comprising i) subjecting an organic feed suspension (a) to acidogenesis and methanogenesis in a first reactor (1); ii) withdrawing an effluent (b) from said first reactor and subjecting it to solid/liquid separation (2),... Agent: Koninklijke Cooperatie Cosun U.a.
20120094352 - Method for cell identification and cell sorting: The present invention relates to a method and to compounds useable in the method for analysis of cells for the pre-sence of an analyte and sorting the cells on the basis of the analyte. The compounds used in the method are optically detectable because of the content of a fluorochrome... Agent: Masterrind Gmbh
20120094353 - low-biomass soil dna/rna extraction yield and quality: The present application discloses a method for pre-treating a sample of a DNA/RNA adsorbing matrix (e.g. soil) suitable for extracting cell-derived (deoxy) ribonucleic acid therefrom, comprising the steps of: isolating a sample of a DNA/RNA adsorbing matrix, said sample comprising DNA/RNA-containing cells; and bringing the sample into contact with DNA... Agent:
20120094354 - Biochip and method for manufacturing the same: A biochip and a method for manufacturing the same are provided. The biochip can increase a surface area on which biomaterials can be immobilized and improve efficiency of reaction. The biochip includes: a substrate; a coating layer formed on the substrate; and a nanoparticle immobilized on the substrate by the... Agent: Electronics And Telecommunications Research Institute
20120094355 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino acids.... Agent: Xyleco, Inc.
20120094356 - In vivo half life increased fusion protein or peptide maintained by sustained in vivo release, and method for increasng in vivo half-life using same: The present invention relates to a fusion protein or peptide, the in vivo half-life of which is increased by maintaining in vivo sustained release, and to a method for increasing in vivo half-life using same. A fusion protein or peptide according to the present invention has excellent in vivo stability... Agent: Alteogen, Inc.
20120094357 - Tab molecules: The present invention relates to TAB molecules, ADEPT constructs directed against TAG-72, and their use in therapy.... Agent:
20120094358 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino acids.... Agent: Xyleco, Inc.
20120094359 - Novel system and method of anaerobic fermentation: The present invention relates to growing anaerobic bacteria by measuring the reduction potential of a growth media at a start time and determining a grow time by correlating the start time reduction potential with said reduction coefficient to calculate when said second anaerobic fermentation system will reach a sufficiently low... Agent: Allergan, Inc.
20120094360 - Method and agent for the bioremediation of petroleum in an aquatic environment: In one embodiment, a bioremediation agent and method of bioremediation of an oil spill are disclosed. The bioremediation agent contains oil-digesting bacteria and bacterial nutrients in a buoyant water semi-insoluble and biodegradable casein product. The bioremediation agent may be distributed by boats or seeded by aircraft to remediate oil from... Agent:
20120094361 - Method of separation of algal biomass from aqueous or marine culture: Disclosed are cross-flow membrane filtration methods for the removal or separation of algal cells from an aqueous environment. The methods of the invention may be used for the simultaneous algal harvesting/dewatering and water/wastewater purification and recycling.... Agent: Arizona Board Of Regents, A Body Of The State Of Arizona, Acting For And Of Behalf Of Arizona State
20120094362 - Production of branched-chain alcohols by photosynthetic microorganisms: The present invention provides genes, polypeptides and expression constructs therefor, recombinant photosynthetic microorganisms, and method of use thereof, such as for the production of branched-chain alcohols (including 2-methyl-1-butanol, 3-methyl-1-butanol, and isobutanol) and derivatives thereof for a variety of uses.... Agent: Synthetic Genomics, Inc.
20120094363 - Method for producing non-putrescible sludge and energy and corresponding plant: The invention relates to a method for producing non-putrescible sludge and energy, wherein said method includes the following steps: (i) producing digested sludge by means of primary sludge digestion; (ii) producing a first aqueous effluent and digested sludge, which are at least partially dehydrated by a first liquid-solid separation of... Agent:
20120094364 - Continuous countercurrent fluidized moving bed (fmb) and/or expanded moving bed (emb): The composite continuous countercurrent fluidized moving bed (FMB) and/or expanded moving bed (EMB) for carrying out processes such as recovery, purification or reaction of single or multiple component/s of interest, by contacting liquid phase containing the said component/s with the solid adsorbent in continuous countercurrent mode. In this composite fluidized... Agent:
20120094365 - Molecular motor: A molecular motor in which multiple concentric cylinders (or nested cones) rotate around a common longitudinal axis. Opposing complementary surfaces of the cylinders or cones are coated with complementary motor protein pairs (such as actin and myosin). The actin and myosin interact with one another in the presence of ATP... Agent: The Government Of The U.s.a As Represented By The Secretary Of The Dept Of Health And Human Services
20120094366 - Reconfigurable chemical process systems: Systems and methods for software-reconfigurable chemical process systems useful in a wide range of applications. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable... Agent:
20120094367 - Blood analysis apparatus: The present invention relates to a blood analysis apparatus X for measuring concentrations of glucose and glycohemoglobin in blood. The blood analysis apparatus X is configured to perform the concentration measurement of the glucose and the glycohemoglobin by one sampling of blood 13. The blood analysis apparatus X is preferably... Agent:
20120094368 - Split spin centrifugation of test elements: High-throughput centrifugation of batches of samples is achieved by dividing a single centrifugation run of a batch of samples into two or more staggered, discrete spins with fewer samples and in which the availability of centrifuge slots for loading or unloading of samples and the subsequent delivery of experimental results... Agent: Ortho-clinical Diagnostics, Inc.
20120094369 - Test material, cassette and meter for using the test material: A test material for providing an indication of a substance in a sample applied to the test material, the test material comprising: an elongate, flexible, substrate; and a plurality of test sites arranged along the substrate, wherein each test site comprises one or more test reagents, and wherein the one... Agent:
20120094370 - Blood glucose test instrument kit having modular component parts: A blood glucose test instrument kit having modular component parts capable of being assembled into a plurality of different handheld blood glucose test instruments is disclosed. The kit comprises the combination of an interconnection platform adapted to connect to a collection of interoperable modules. The collection of interoperable modules including:... Agent: Roche Diagnostics Operations, Inc.
20120094371 - Test strip for h. pylori detection: A test device, including: a compartment defining an environment and comprising a specimen region; an indicator medium disposed in the compartment; a separation medium disposed in the compartment between the specimen region and the indicator medium; an active ingredient adjacent the specimen region; and a color indicator disposed on the... Agent:
20120094372 - Ex vivo cell culture: enabling process and devices: A device which is capable of providing an artificial condition for three dimensional culture of animal and human cells comprising of two components; First component is a vessel coated in the entire internal surface rendered not suitable for cell adhesion and proliferation and a second component is a cell interactive... Agent:
20120094373 - Container for nucleic acid amplification reaction: A container for nucleic acid amplification reaction is disclosed. The container includes a capillary and a conductor. The conductor tightly surrounds the capillary for heating the capillary evenly.... Agent: Genereach Biotechnology Corp.
20120094375 - Enhanced engineered native promoters and uses thereof: We describe methods and DNA constructs/engineered mammalian promoters to enhance native promoter activity while retaining inherent regulation by inserting multi-copy response elements (REs) into non-adjacent locations. Multiple copies of REs are clustered in a group forming a transcription factor response element segment. The segment is at least duplicated in tandem... Agent: The General Hospital Corporation
20120094374 - Micrornas and uses thereof: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of... Agent:
20120094376 - Engineered extracellular matrices control stem cell behavior: A composition for culturing stem cells is provided. The composition comprises an engineered purified collagen based matrix that has been formed under controlled conditions to have the desired microstructure and mechanical properties. The engineered purified collagen based matrix compositions of the present invention can be used alone or in combination... Agent:
20120094377 - Modified fluorescent proteins and methods for using same: Nucleic acid molecules encoding improved fluorescent mutants of the mKate2 protein, variants and derivatives thereof are provided, as well as proteins and peptides encoded by these nucleic acids. Also provided are proteins that are substantially similar to, or derivatives, homologues, or mutants of, the above-referenced specific proteins. Also provided are... Agent: Evrogen Jsc
20120094378 - Nucleic acids encoding for antifungal bifunctional molecules for treating fungal infection: The present invention is directed to nucleic acids encoding for fusion peptides comprising a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia, as well as vectors having the nucleic acids of the invention and host cells having the vectors. The fusion peptides... Agent: Pheromonicin Biotech, Ltd.
20120094379 - Human endometriosis cell: The present invention discloses a human endometriosis cell, EM 257, which has been stored in the food industry research and development institute. Results obtained from a flow cytometry reveal that the human endometriosis cell of the present invention is positive for the mesnchymal stem cell surface antigens, such as CD44,... Agent: National Changhua University Of Education
20120094380 - Human multipotent embryonic stem cell-like progenitor cells: The invention provides a plurality of embryonic stem cell-like progenitor cells, which are isolated from a human tissue by a systemic screening of human mesenchymal stromal stem/progenitor cells and a cell sorting by a cell antigen selected from the group consisting of CD34, CD117, CD133, CD201, GloboH and combination thereof,... Agent:
20120094381 - Methods of neural conversion of human embryonic stem cells: The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hESC), somatic stem cells, and induced human pluripotent stem cells (hiPSC) using novel culture conditions. Specifically, methods are provided for... Agent:
20120094382 - Molecular delivery with nanowires: A molecular delivery system including a plurality of nanowires (e.g., Si NWs), each of the nanowires having a surface layer formed of a silicon-containing material and a covalently bound linker (e.g., silane linker) attached to the surface layer and optionally including a substrate to which the nanowires are adhered or... Agent: President And Fellows Of Harvard College
20120094383 - Methods for inducing cell death in pluripotent stem cells and differentiated cells other than cardiac myocytes: The present invention has as its object developing a method that does not involve genomic modification and which yet is capable of inducing cell death in pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, as well as in differentiated cells other than cardiomyocytes derived from... Agent: Daiichi Sankyo Company, Limited
20120094384 - Use of compounds for differentiation of cells: The present invention provides a method for differentiating an undifferentiated cell, said method comprising contacting an undifferentiated cell with certain compounds of Formula (I) or a salt thereof.... Agent:
20120094385 - Gene positioning system for plastidic transformation and products thereof: The present invention is directed to Gene Positioning technology for biosynthesis of one or more products of interest via plastid transformation of plants or algae, such as for example tobacco, Lemna, Rhodomonas and Cryptomonas, with pseudogene vectors containing polynucleotides encoding one or more products of interest. The present invention is... Agent: Kuehnle Agrosystems, Inc.
20120094386 - Engineering salt tolerance in photosynthetic microorganisms: Provided herein are compositions and methods for engineering salt tolerance and producing products by photosynthetic organisms. The photosynthetic organisms can be genetically modified to be salt tolerant as compared to an unmodified organism and to produce useful products. The methods and compositions of the disclosure are useful in many therapeutic... Agent: Sapphire Energy, Inc.04/12/2012 > 81 patent applications in 44 patent subcategories.
20120088224 - Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment... Agent: Caridianbct, Inc.
20120088225 - Method of detecting major in-hospital ischemic complications and predicting length of stay at an intensive care unit: Methods of detecting major ischemic complications in critically ill patients comprise a) determining the blood concentration of glycerol at least once per hour; b) comparing the obtained blood concentration of glycerol with a defined critical level; and c) based on the comparison of step b), identifying patients experiencing or being... Agent:
20120088231 - Biological specimen collection/transport compositions and methods: Disclosed are compositions for collecting, storing, and transporting populations of nucleic acids from biological specimens, and clinical, forensic, or environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the... Agent: Longhorn Vaccines & Diagnostics, LLC
20120088227 - Devices and process for separating plasma from a blood sample: The present invention pertains to a device for separating plasma from a blood sample comprising a stacked structure which is provided with a first portion including a separating member having a first surface for applying or receiving the blood sample, wherein the separating member is adapted to permit the passage... Agent: Roche Molecular Systems, Inc.
20120088228 - Methods of producing high titer, high purity virus stocks and methods of use thereof: The purity and titer of virus stocks used for virus clearance studies have a significant influence on study outcome, and impact how well the scale-down model represents the production-scale process. Impurities in virus stocks are particularly important in the testing of small virus retentive filters because these impurities may cause... Agent: Millipore Corporation
20120088226 - Nucleic acid extraction method: The present invention relates to a nucleic acid extracting apparatus, and the nucleic acid extracting apparatus can include a pipe-shaped tube having an open outlet at one side thereof, and a hydrogel column that is provided inside the tube and filters impurities excluding an extraction target material.... Agent: Postech Academy-industry Foundation
20120088229 - Surface plasmon resonance sensor: The application relates to a sensor using a gold layer (3) with embedded nanodiamonds (2) on which surface plasmon resonance (SPR) is used to detect target molecules (5).... Agent: Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.
20120088230 - System and method for cell analysis: A system for enumeration of objects such as cells in a sample is disclosed. The system uses a low-cost cartridge and a reader instrument, based on planar waveguide imaging technology. Cells of a blood sample may be stained with fluorescence-tagged antibodies and are loaded onto the cartridge where the differentially... Agent:
20120088232 - Aptamer-based device for detection of cancer markers and methods of use: Systems and methods are provided for detecting and quantitating one or more compounds or molecules in a sample. An aptamer-based point-of-care device (such as a strip) is described for rapid detection of target molecules such as the cancer marker p-glycoprotein (Pgp). Fluorescent molecules or gold nanoparticles may be used to... Agent: Missouri State University
20120088233 - Method of preparing quality control material for ffpe: This specification relates to Formalin-fixed embedded quality control material for use for validation, verification, and to run controls for molecular assays. The quality control material can be used for a variety of tissues and for a variety of molecular assays. The quality control material can be used in commercial labs... Agent: Life Technologies Corporation
20120088242 - Assay for mycobacterium avium/intracellulare nucleic acid: Disclosed is a method for determining the presence of Mycobacterium avium complex nucleic acids in a biological sample. In particular, the mig gene of M. avium and the DT1 gene of M. intracellulare are detected, preferably following amplification. In addition, the method distinguishes between species of M. avium and M.... Agent: Quest Diagnostics Investments Incorporated
20120088241 - Bioreactive agents: This invention relates to agents and conjugates to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents coupled to substrates by... Agent: The Trustees Of Boston University
20120088238 - Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases: The present invention relates to targeted conversion of alpha-hydroxyalkylated residues in biomolecules in the presence of a directing methyltransferase, namely to targeted removal of the alpha-hydroxyalkyl moieties to give unmodified residues, or targeted derivatization of the alpha-hydroxyalkyl groups by covalent coupling of non-cofactor compounds represented by formula HQ-LX1 wherein X... Agent: Biotechnologijos Institutas
20120088239 - Detection of chromosomal inversions: A method and a kit for the identification of chromosomal inversions are described. Chromosomal inversions are difficult to detect unless they are quite large. The improved ability to detect chromosomal inversions is important to a number of medical applications, such as cancer and birth defects, as examples. Reporter species are... Agent: Kromatid, Inc.
20120088234 - Device for performing pcrs: A device is described to perform reactions, in which the device includes at least one test cell with a cavity to receive the test sample and at least a first, a second and a third spatially discrete regulatable temperature units. The three temperature units thus define three spatially discrete temperature... Agent:
20120088237 - Engineering a novel methylation-specific restriction endonuclease: A restriction endonuclease is provided that has been engineered to have a cleavage specificity for a DNA recognition sequence containing a modified nucleotide. Methods for engineering enzymes to cleave DNA containing modified nucleotides at specific sequences are provided.... Agent: New England Biolabs, Inc.
20120088240 - Functionalized polymer biosensor: One aspect of the present disclosure relates to a novel sensor mechanism based on the aggregation of nanoparticles for target molecule detection and quantification. The nanoparticles that can be used include non-conducting polymers and conducting polymers such as polyaniline, polypyrrole and polythiophene derived nanofibers. Embodiments can include covalently functionalized nanoparticles... Agent:
20120088235 - High throughput nucleic acid sequencing by expansion and related methods: Nucleic acid sequencing methods and related products and methods for detection and presentation of the same are disclosed. Methods for sequencing a target nucleic acid comprise providing a daughter strand produced by a template-directed synthesis, the daughter strand comprising a plurality of subunits coupled in a sequence corresponding to a... Agent: Stratos Genomics, Inc.
20120088236 - Methods and systems for sequential determination of genetic mutations and/or varients: The present invention relates to methods and systems for genome scanning using high resolution melting analysis for identifying mutations and/or variants in genes of interest.... Agent: Canon U.s. Life Sciences, Inc.
20120088244 - Composition and methods for rapid detection of hiv by loop-mediated isothermal amplification (lamp): Methods and compositions for detection of HIV nucleic acids in a sample, such as a biological sample obtained from a human subject, are provided according to embodiments of the present invention which include providing a reaction mixture including at least one LAMP, accelerated LAMP, RT-LAMP or RT-accelerated LAMP assay primer... Agent: The Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services
20120088248 - In vitro methods for determining an intracellular free magnesium deficiency of individuals by determining the expression rate of a cellular mg2+ transporter gene: An in vitro method is disclosed for determining the presence or absence of an intracellular free magnesium deficiency in a human individual by determining the expression rate of at least one cellular Mg2+ transporter gene showing a direct correlation between its expression rate and the intracellular free magnesium ion concentration... Agent: Protina Pharmazeutische Gesellschaft Mbh
20120088247 - Materials and methods for treating patients with taxoxifen: A pathway for the metabolism of tamoxifen is identified including the activity of at least 2 different isoforms of UGY2B7. This pathway includes isozymes of CYP3A which convert tamoxifen (TAM) to N-desmethyl-TAM, which is then converted to endoxifen by the action of CYP2D6. Once formed, endoxifen may be degraded by... Agent: Indian University Research & Technology Corporatio
20120088243 - Method for detection of genetically modified maize bt11: The invention discloses a method for detection of genetically modified maize BT11. The principle of the method is that the DNA template of the sample is amplified at a temperature of 63° C.˜65° C. for 45˜60 min by using 4 specific primers and a DNA polymerase with strand displacement activity.... Agent: Central Lab Of Tianjin Academy Of Agricultural Sciences
20120088245 - Methods of diagnosing insulin resistance and sensitivity: Methods of diagnosing susceptibility to metabolic insulin resistance and other related conditions are disclosed. The method provides means of diagnosing susceptibility to insulin resistance in Hispanic Americans by determining the presence of a risk haplotype at the LPL locus, the LPIN1 locus, and/or elevated levels of gamma-glutamyl transferase.... Agent: Cedars-sinai Medical Center
20120088249 - Microfluidic devices: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.... Agent: Integenx Inc.
20120088246 - Real time pcr detection of single nucleotide polymorphisms: Disclosed are methods and kits for the detection of a polymorphism during real-time PCR. Real-time PCR amplification of a target nucleic acid sequence is performed using PCR primer primers that anneal to sequences flanking a single nucleotide polymorphism (SNP) of interest. The real-time PCR reaction includes a labeled probe comprising... Agent:
20120088250 - Devices, systems, and methods for the collection of body fluids: Devices, systems, and methods for the collection of biological samples. In at least one exemplary embodiment, a device comprises a collection medium having top and bottom surfaces and a predetermined size and shape, the top surface comprising a position marker and at least one binding site operable to bind a... Agent: Bioanalytical Systems, Inc.
20120088251 - Mass spectrometric methods and products: The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.... Agent: President And Fellows Of Harvard College
20120088252 - Device and method for the detection of particles: The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is... Agent: Alere Technologies Gmbh
20120088253 - Method for measuring glycated hemoglobin: Provided is a method for measuring glycated hemoglobin. The method includes a hemolysis step of hemolyzing a blood sample with a hemolysate, a reaction step of reacting the hemolyzed blood sample with bead conjugates in which beads are conjugated with glycated hemoglobin binding materials, a first measuring step of measuring... Agent: Infopia Co., Ltd.
20120088254 - Whole blood assay of an intracellular biomarker of a cell signalling pathway use in measuring the activation of a predetermined cell population: A method for assaying by ELISA, carried out on a whole blood sample, of the cellular activation state of a predetermined population of cells of the sample, includes determining the phosphorylation state of an intracellular protein involved in a cell signaling pathway (biomarker). A particular application of the method for... Agent: Biocytex
20120088256 - Anaplasma translocated substrate-1 (ats-1) and sero-detection of anaplasma phagocytophilum: Disclosed is the use of isolated Ats-1 protein in Anaplasma phagocytophilum in the ELISA detection of Anaplasma pathogen. The recombinant expression of Ats-1 and its use as a kit for ELISA are also disclosed.... Agent: Medical Diagnostic Laboratories LLC
20120088255 - Her-2 binding antagonists: There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO:1, wherein the polypeptide binds to the extracellular domain... Agent: Oregon Health & Science University
20120088258 - Integrated device for surface-contact sampling, extraction and electrochemical measurements: The invention relates to a device and method for non-invasive detection of an analyte in a fluid sample. In one embodiment, the device comprises: a collection chamber containing an absorbent hydrogel material; a fluidic channel connected to the collection chamber; a sensing chamber connected to the fluidic channel, wherein the... Agent: Arizona Board Of Regents, A Body Corporate Of The State Of Arizona
20120088257 - Method for diagnosing vasculitis: The invention relates to a method for the in vitro detection of vasculitis or the risk of developing vasculitis, including determining the presence and/or the amount of anti-endothelial cell antibodies (AECA) or anti-vascular smooth muscle cell (VSMC) antibodies in a biological sample from a patient.... Agent: Assistance Publique - Hopitaux De Paris
20120088259 - Post-translation modified cardiac troponin t as a biomarker of a risk for heart failure: The present invention relates to methods and kits for the prediction of risk for heart failure using post-translation modified forms of cardiac troponin T as a biomarker.... Agent: Institut Pasteur De Lille
20120088260 - Mass spectrometry assay for plasma-renin: Provided are methods for measuring renin activity in a plasma sample using mass spectrometry. The methods generally involve ionizing purified angiotensin 1 from the sample and detecting the amount of angiotensin 1 ions generated. The amount of detected angiotensin 1 ions are then related to the amount of angiotensin 1... Agent: Quest Diagnostics Investments Incorporated
20120088261 - Cell labeling and imaging using multifunctional perfluorocarbon nanoemulsion: The present invention relates to cell labeling and imaging using a multifunctional perfluorocarbon (PFC) nanoemulsion. In particular, the perfluorocarbon nanoemulsion containing optical nanoparticle is provided with both optical characteristics and 19F magnetic resonance characteristics, thus can be used for magnetic resonance imaging (MRI) and optical imaging (OI) simultaneously. Cell labeling... Agent: Korea Research Institute Of Bioscience And Biotechnology
20120088262 - Cyanine compounds, conjugates and method of use: Cyanine compounds having the general formula I, conjugates, complexes, and compositions comprising the cyanine compounds are provided. Fluorescence resonance energy transfer (FRET) dye pairs and viability dyes are also provided.... Agent: Millipore Corporation
20120088263 - Sample test cards: The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples. In one embodiment, the sample test cards of the present invention comprise one or more fluid over-flow reservoirs, wherein the over-flow reservoirs are operatively connected to a distribution... Agent: Biomerieux, Inc.
20120088264 - Methods for determining efficacy of chemotherapeutic agents: An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying the best... Agent: Precision Therapeutics, Inc.
20120088266 - Bioreactor process for production of hydrogen from biomass: This invention relates to bioreactor processes, particularly bioreactor processes for the production of hydrogen gas from biomass, more particularly to bioreactor processes for the production of hydrogen gas employing a mixed anaerobic thermophilic bacterial consortium during the anaerobic fermentation of biomass.... Agent: University Of The Witwatersrand, Johannesburg
20120088265 - Mold pathogen detection apparatus: The present invention is a mold pathogen detection apparatus in which an agar strip is exposed to the environment being tested for a period of time and then exposed to a non-UV light to determine the amount of light passing through the agar strip.... Agent:
20120088267 - Tissue sample preprocessing methods and devices: A first permeable mesh membrane may be configured to be tautly stretched over a tissue sample and overlaid over a surface. A first permeable mesh membrane may sandwich and secure a tissue sample in between a first permeable mesh membrane and a surface. A first permeable mesh membrane may have... Agent:
20120088268 - Recombinant production of peptides: The present invention relates to repetitive self-assembling precursor proteins, nucleic acid sequences and expression constructs encoding the same, and to methods for recombinant production of peptides using such precursor proteins.... Agent: Basf Se
20120088269 - Solution for cell-free protein synthesis, kit for cell-free protein synthesis, and method of protein synthesis: This invention enables synthesis of proteins that were difficult to synthesize via a conventional cell-free protein synthesis system and increases the amount of proteins synthesized. Cell-free protein synthesis is carried out in a solution for cell-free protein synthesis containing a certain compound, such as trimethylglycine, L-carnitine, or sarcosine.... Agent: Toyota Jidosha Kabushiki Kaisha
20120088270 - Methods for producing antifungal bifunctional molecules for treating fungal infection: The present invention is directed to methods of using nucleic acid molecules encoding for fusion peptides to produce the fusion peptides. The methods can include preparing or providing the nucleic acid molecules that having a fungal targeting agent (e.g., a fungal pheromone, such as alpha-mating pheromone) and a channel-forming domain... Agent: Pheromonicin Biotech, Ltd.
20120088272 - Methods of generating hybrid/chimeric cells, and uses thereof: The present invention relates to hybrid cells and methods for producing hybrid cells. In particular, the invention relates to hybrid cells generated from the hybridization of at least three cells where at least two cells are derived from different lineages. The invention further relates to the use of hybrid cells... Agent: Bts Research International Pty Ltd
20120088271 - Use of an endogenous 2-micron yeast plasmid for gene over expression: Methods and compositions for making stable recombinant yeast 2 μm plasmids are provided. Homologous recombination is performed to clone a nucleic acid of interest into the yeast 2 μm plasmid. Heterologous nucleic acid subsequences are recombined between an FLP and a REP2 gene of the plasmid.... Agent: Codexis, Inc.
20120088273 - Novel cellulose and ligno-cellulose active proteins: The invention relates to a lignocellulose active protein comprising a DUF1996 domain and proteins that additionally comprise a CBM1 domain. Also included in the invention are proteins with a new domain, characterized by the consensus sequence [GA]-[ST]-[IV]-[ILV]-W-[DS]-G-[RIFS]-F-[ND]-[DS]-X (residues 1-12 of SEQ ID NOS:6-7). The invention relates to a lignocellulose active... Agent: Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno
20120088274 - Polypeptides having beta-glucosidase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes. Inc.
20120088275 - Reagents and methods for pcr: Modified double-stranded oligonucleotides that have terminal regions on each of their strands, that have a hybrid length of 6-50 nucleotides long, that have a melting temperature Tm of at least 32° C., and that include 2-4 modifying groups, each covalently attached to a different terminal region, preferably to a terminal... Agent: Brandeis University
20120088276 - Method for using ref protein as a targeted reca-dependent nuclease: Kits and a method for cleaving double-stranded DNA using Ref and RecA protein and variants thereof at a site having a DNA sequence homologous to the sequence on a single-stranded DNA targeting fragment are disclosed.... Agent: Wisconsin Alumni Research Foundation
20120088277 - Glucoamylase variants: The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.... Agent: Novozymes A/s
20120088278 - Utilization of wastewater for microalgal cultivation: Bioreactors and methods for cultivating microalgae using fruit wastewater are provided herein. The bioreactor and methods include features and modifications to improve heterotrophic growth efficiency by providing a light signal.... Agent: C/o Phycoil Biotech International, Inc.
20120088279 - Algal lipid production: Methods for increasing the levels of lipids in oleaginous algae are described. Lipid levels in algae can be increased by stress, such as nutrient stress, after which the lipid can be harvested from the algae using a non-destructive extraction process. The stress may be provided in a periodic or “pulsed”... Agent: Phycal, Inc.
20120088280 - Gene encoding polymer synthase and a process for producing polymer: An isolated polynucleotide encoding for a polypeptide comprising an amino acid sequence set forth in SEQ ID NO: 1 with polymer synthase activity.... Agent:
20120088281 - Thiolase with improved activity and method of producing biobutanol using the same: The present invention relates to a modified thiolase protein with an improved activity, a polynucleotide encoding the modified protein, an expression vector including the polynucleotide, and a transformant, to a composition for producing a biobutanol including the thiolase with an improved activity or a cell expressing the thiolase, and to... Agent: Postech Academy-industry Foundation
20120088282 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from anaerobic fermentation of a gaseous substrate containing at least one reducing gas in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This... Agent: Ineos Bio Limited
20120088283 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from anaerobic fermentation of a gaseous substrate containing at least one reducing gas in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This... Agent: Ineos Bio Limited
20120088284 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from anaerobic fermentation of a gaseous substrate containing at least one reducing gas in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This... Agent: Ineos Bio Limited
20120088285 - Process for treating a substrate with an enzyme: In a process for hydrolyzing plant material in aqueous solution or suspension with an enzyme, the enzyme is delivered in solid form (e.g., as a spray-dried powder) in closed containers (such as paper bags or cardboard boxes), which are added directly in the process (i.e. addition of whole boxes/bags). The... Agent: Novozymes A/s
20120088286 - Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same: Provided is a method of separating microorganisms from a sample including contacting the sample containing microorganisms with an inorganic on exchange material such that the sample reacts with the inorganic on exchange material, and contacting the reacted sample with a means for capturing microorganisms.... Agent: Samsung Electronics Co., Ltd.
20120088287 - Cripto antagonism of activin and tgf-b signaling: Cripto, a developmental oncoprotein, antagonizes activin and TGF-b signaling by forming a complex with activin and TGF-b and their type II receptors. This complex precludes the formation of a functional activin/TGF-b•type II•type I complex, thereby blocking the signaling of activin and TGF-b. Cripto may be generally capable of blocking antiproliferative... Agent: Research Development Foundation
20120088288 - Subtilases: The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase.... Agent: Novozymes A/s
20120088289 - Vmp-like sequences of pathogenic borrelia species and strains: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis.... Agent:
20120088290 - Ethanol yield and reduction of biomass accumulation in the recombinant strain of saccharomyces cerevisiae overexpressing atpase: A new approach for increase of ethanol yield during alcoholic fermentation via decrease of biomass accumulation by using ATP degrading enzymes is described. The part of the Saccharomyces cerevisiae SSB1 gene coding for cytosolic ATPase domain of ribosome associated chaperon cloned into expression cassette under control of the glycerol-3-phosphate dehydrogenase... Agent: Archer Daniels Midland Company
20120088291 - Enzymatic textile colour modification: n
20120088292 - Methods and formulations using carbonic anhydrase and reaction compound combinations: Disclosed is a formulation for the absorption of CO2, which comprises water, at least one CO2 absorption compound and a carbonic anhydrase as an activator to enhance the absorption capacity of the CO2 absorption compound. The invention also concerns the use of carbonic anhydrase, in a CO2 absorption solution to... Agent: Co2 Solution Inc.
20120088293 - Analyzer: An analyzer comprising: a first specimen holder configured to hold a plurality of first specimen containers; a conveying assembly for conveying the first specimen containers held in the first specimen holder; a second specimen holder arranged at a position higher than an upper end of the first specimen containers held... Agent: Sysmex Corporation
20120088294 - Method for single nucleotide polymorphism and mutation detection using real time polymerase chain reaction microarray: A method and apparatus for real-time, simultaneous, qualitative measurement of one or more single nucleotide polymorphisms in one or more target nucleic acids is provided. This method involves combining a polymerase chain reaction (PCR) technique with an evanescent wave technique.... Agent: Honeywell International Inc.
20120088295 - Device for concentrating and separating cells: Provided is a device for concentrating and separating cells, which has a function for continuously concentrating cells; a function for then continuously arranging the concentrated cells in predetermined regions of a flow path; a function for simultaneously identifying shape and fluorescent emission in one-cell units on the basis of cell... Agent: National Iniversity Corporation Tokyo Medical And Dental
20120088296 - Photobioreactor system: A space efficient photo-bioreactor. The bioreactor grows microalgae in a tall array of transparent flooded tubes. A nutrient media is circulated through the tubes. The array is configured to maximize the amount of sunlight falling upon each tube so that growth of the microalgae is as uniform as possible. Gassing/degassing... Agent:
20120088298 - Ikkalpha and ikkbeta specific inhibitors: A method for modulating NF-κB dependent gene transcription in a cell comprised of modulating IKKα and IKKβ protein and protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-κB dependent gene transcription.... Agent: Boehringer Ingelheim Pharmaceuticals, Inc.
20120088297 - Mycobacterial antigens expressed under low oxygen tension: A method is provided for identifying mycobacterial genes that are induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of up to 10% air saturation measured at 37° C. when compared with a dissolved oxygen tension of at least 40% air saturation measured at 37° C.... Agent: Health Protection Agency
20120088299 - Mammalian cell lines for increasing longevity and protein yield from a cell culture: Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hamiones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene,... Agent: Immunomedics, Inc.
20120088300 - Compositions and methods for promoting the generation of definitive endoderm: Certain embodiments disclosed herein are directed to a method of producing endoderm cells, such as definitive endoderm cells by exposing stem cells such as embryonic stem cells or induced pluripotent stem (iPS) cells to an effective amount of at least one compound described herein to differentiate the stem cells into... Agent: President And Fellows Of Harvard College
20120088301 - Factor taking part in transcription control: HDART binds with HDAC (histone deacetylase) and function as a repressor. HDART directly binds with Skip functioning as a transcription co-activator of a nuclear receptor to repress the transcription of the nuclear receptor. Moreover, HDART is one of transcription co-repressors of nuclear receptor, and binds with HDAC thereby enabling intense... Agent: Sony Corporation
20120088302 - Cell culture: A method for determining the effect of a plurality of culture conditions on a cell, comprising the steps of a) providing a first set of groups of cell units each comprising one or more cells, and exposing said groups to desired culture conditions; (b) pooling two or more of said... Agent: Plasticell Limited
20120088303 - Peptide fractions promoting growth and synthesis of desired product(s) into cell and/or tissue culture: The invention relates to preparing and/or supplementing a cell or tissue culture medium. In particular, said invention relates to a serum-free and/or protein-free cell culture medium comprising peptide fractions isolated from rapseeds, in particular rapseeds cakes. A method for the production of a cell culture comprising said peptide fractions and... Agent:
20120088304 - Methods of generating cells exhibiting phenotypic plasticity: The present invention relates to cellular differentiation and, in particular to hybrid cells that exhibit phenotypic plasticity and methods for producing these cells. The invention also relates to methods for generating specific cells of a desired phenotype. The invention still further relates to methods of producing hybrid cells with a... Agent: Stephen Sanig Research Institute Ltd.04/05/2012 > 63 patent applications in 38 patent subcategories.
20120082977 - Articles with matrix comprising a cell extractant and biodetection methods thereof: Articles are provided for the detection of cells in a sample. The articles include a release element. The release element comprises an encapsulating agent and a cell extractant. The release element controls the release of the cell extractant into a liquid mixture containing the sample. Methods of use are also... Agent:
20120082975 - Dna-based molecular switches and uses thereof: Disclosed are nucleic acid-based molecular switches that respond to changes in pH. The switches may be used in DNA nanodevices. The switches may also act as sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The switch includes an A-motif that forms at acidic... Agent:
20120082976 - Method of screening for insulin secretion-potentiating agents: Disclosed are a novel method of screening for insulin secretion-potentiating agents as well as means for performing such screening. The means include a DNA encoding fluorescent-labeled Epac2 comprising two different DNAs encoding two different fluorescent proteins which emit fluorescent light with wavelength differing from each other and a DNA encoding... Agent: Kobe University
20120082978 - Cell analysis on microfluidic chips: The present invention provides for a method of implementing fluorescent in situ hybridization (FISH) or other cellular analysis processes using intact cells within a microfluidic, chip-based, apparatus. The invention further provides for a method of cellular immobilization within a microfluidic device. Also provided is a method for automated analysis of... Agent:
20120082979 - Compositions, methods, and kits for (mis)ligating oligonucleotides: Methods, reagents, and kits for (mis)ligating oligonucleotide probes or for identifying at least one target nucleotide are disclosed. One can enhance the generation of misligation product using a ligase under reaction conditions and with reagents where that particular ligase is prone to misligation. Alternatively, one can decrease or avoid generating... Agent: Life Technologies Corporation
20120082982 - Cystic fibrosis gene mutations: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further... Agent: Quest Diagnostics Investments Incorporated
20120082981 - Enzyme mixture: Polymorphisms are present throughout an organism's genome, and understanding which alleles are present in a particular organism's genome can be advantageous. When probing the identity of these alleles, one must minimize incorrect readings due to inefficiencies in the system. In hydrolysis probe applications, these inefficiencies may be due to over-activity... Agent: Finnzymes Oy
20120082983 - Microbial reductive dehalogenation of vinyl chloride: Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of... Agent: The Board Of Trustees Of The Leland Stanford Junior University
20120082984 - Nucleic acids for detection and discrimination of genotypes of chlamydophila psittaci: Methods of detecting Chlamydophila, including differentiating between species of Chlamydophila and/or strains of Chlamydophila psittaci are disclosed, for example to detect and genotype a Chlamydophila psittaci infection. A sample suspected of containing a nucleic acid of a Chlamydophila, is screened for the presence of that nucleic acid. The presence of... Agent: The Govt. Of U.s.a. As Represented By The Secretary Of The Dept.of Health And Human Services
20120082980 - Pna probes, probe sets, methods and kits pertaining to the detection of candida: This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of one or more species of Candida yeast. Non-limiting examples of probing nucleobase sequences that can be used for the probes of this invention can be selected from the group consisting of: AGA-GAG-CAG-CAT-GCA... Agent: Life Technologies Corporation
20120082986 - Cell proliferation inhibitor: The present inventors revealed a TTF-1-specific oncogenic process by elucidating the molecular mechanism regulated by the master regulatory factor TTF-1. The present inventors focused on the elucidation of the essence of the lineage-specific survival signal which is a novel canceration signal. Thus, the present inventors found that the expression of... Agent: National University Corporation Nagoya University
20120082993 - Detecting cancer with anti-cxcl16 and anti-cxcr6 antibodies: Methods for detecting cancer or monitoring cancer progression in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the... Agent: Morehouse School Of Medicine
20120082991 - Detection of rna-interacting regions in dna: The present invention provides methods and kits for detecting RNA-interacting regions in genomic DNA.... Agent: Bio-rad Laboratories, Inc.
20120082992 - Equine parasite detection: The present invention provides a method of diagnosing a cyathostomin infection, said method comprising the step of identifying a level of anti-cyathostomin larval antigen antibodies in a sample, wherein a level of anti-cyathostomin larval antigen antibodies is indicative of a cyathostomin infection.... Agent: Moredun Research Institute
20120082994 - Expression levels of col4a1 and other markers correlating with progression or non-progression of bladder cancer: Disclosed is determining expression levels protective or harmful markers for bladder cancer prognosis; particularly, determining the expression levels of COL4A3BP alone or in combination with the expression levels of MBNL2, FABP4, and NEK1 or other markers where increased expression levels of these protective markers relative to a control correlates with... Agent:
20120082988 - Homogeneous analyte detection: The present invention provides novel binding pair compositions of defined and limited stability comprising nucleic acid detection markers useful for the homogeneous, sensitive detection of analytes. Also provided are methods for the sensitive homogenous detection of analytes, particularly analytes of clinical relevance. Kits for preparing binding pairs of the invention... Agent:
20120082995 - Method for quantitative pcr amplification of deoxyribonucleic acids from a sample containing pcr inhibitors: The present invention is directed to a method for quantitative PCR amplification of deoxyribonucleic acids (DNA) from a sample containing PCR inhibitors such as biological, clinical or environmental samples. In the method of the invention an inhibitor-tolerant DNA polymerase is used in a pre-amplification step to increase the copy number... Agent:
20120082990 - Recombinase polymerase amplification: This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling... Agent: Alere San Diego, Inc.
20120082985 - Sensing and identifying biological samples on microfluidic devices: A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the... Agent:
20120082987 - Transgenic non-human animals expressing human blood clotting factors and uses thereof: The present invention relates, in general, to development of non-human transgenic animals expressing a human blood clotting factor, such as Factor VIII, Factor VII, Factor IX and von Willebrand factor. The invention further provides methods of detecting immunogenic events against human blood clotting factor using the transgenic animals described.... Agent: Baxter Healthcare S.a.
20120082989 - Uses for long polar fimbriae genes of pathogenic escherichia coli strains: Provided are methods for identifying lpf genes in pathogenic serotypes of the Enterobacteriaceae family and for differentiating Escherichia coli (E. coli) O157:H7 strains in an isolate using primer pairs specific to lpf gene variants, particularly IpfA1 and/or lpfA 2 genes and amplicon size of the PCR product to identify prototypic... Agent:
20120082996 - Il-21 variants: IL-21 variants nucleic acid sequences are provided that encode a peptide having deletions and zero to ten conservative amino acid substitutions in the region of amino acid residues 65-96 of SEQ ID. NO:2.... Agent:
20120082997 - Taggants and method of using same: A composition of matter which comprises a non-gaseous nitrogen containing compound; and a spore of a micro-organism. A method of determining a source of a material the material being an explosive or a substance used in the preparation of the explosive, the material comprises a spore of a micro-organism uniquely... Agent: Technion Research & Development
20120082998 - Detection of bacterial infections in subjects suffering from dyspnea: The field of the present invention is the diagnosis and/or prediction and/or therapy follow-up of bacterial infections in subjects suffering from dyspnea. It is a subject of the present invention to provide a method for the diagnosis and/or prediction and/or therapy follow-up of bacterial infections in subjects suffering from dyspnea.... Agent: B.r.a.h.m.s Gmbh
20120083004 - Diagnostic method for celiac sprue: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.... Agent: The Board Of Trustees Of The Leland Stanford Junior University
20120083001 - Method for transporting potassium ions from front side to back side of lipid bilayer membrane: An object of the present invention is to detect a specific chemical substance with high sensitivity and high precision. By using a specific lipid bilayer membrane, a chemical substance is detected with high sensitivity and high precision. Here, the specific lipid bilayer membrane comprises a chemical substance receptor, a chimeric... Agent: Panasonic Corporation
20120083002 - Methods for modulating the development of dopamine neuron by the dopamine d2 receptor and compositions thereof: The present invention relates to a composition for modulating the activation of Nurr1, the composition comprising an agonist or an antagonist of a dopamine D2 receptor, methods for modulating the activation of Nurr1 by the dopamine D2 receptor, a method and composition for treating Nurr1-related diseases using the dopamine D2... Agent: Korea University Industry And Academy Cooperation Foundation
20120083000 - Neuropeptide release assay for sodium channels: Methods and compositions for using genetically modified non-human animals are provided, wherein the genetic modification comprises a humanization of the one or more extracellular pore loops of a NaV1.7 channel protein or a complete humanization of an endogenous NaV1.7 gene. Methods for using isolated DRG cultures from genetically modified non-human... Agent: Regeneron Pharmaceuticals, Inc.
20120083003 - Parkin substrate and assay: The invention provides in vitro, ex vivo, and in vivo assays for Parkin activity, in which Parkin-mediated ubiquitination of a Sept4 protein is measured. The assays may be used to screen for agents that modulate Parkin protein ligase activity.... Agent: Elan Pharma International Limited
20120083005 - Methods for in vitro cancer cell detection, diagnosis and therapy using multidomain biotags: In one embodiment, a biotag for targeting a cancer biomarker is provided. The biotag may include a cancer biomarker binding domain, an internalization domain, an endosomal escape domain, a lysosomal escape domain, a reporter binding domain, and a reporter, wherein the reporter is a diagnostic agent. In some aspects, the... Agent:
20120083006 - Methods for the identification of kinase interacting molecules and for the purification of kinase proteins: The present invention relates to immobilization compounds (I), immobilization products and preparations thereof as well as methods and uses for the identification of kinase interacting compounds or for the purification or identification of kinase proteins.... Agent: Cellzone Ag
20120083007 - Basophil activation based allergy diagnostic test: Methods are provided for determining a subject's susceptibility to an allergic reaction upon exposure to an offending allergen. Methods are also provided for determining and monitoring a subject's responsiveness to ongoing allergy treatment.... Agent:
20120082999 - New antibody cocktail: The present invention relates to a composition comprising at least three primary antibodies or fragments thereof, wherein the at least three antibodies or fragments thereof binds specifically to at least three different proteins, and wherein the at least three different proteins are AMCAR, CK 5/6, and HMWC. Methods for using... Agent:
20120083008 - Methods for obtaining molecules with reduced immunogenicity: The invention provides a method for reducing immunogenicity of a peptide, protein or protein complex in an individual comprising introducing at least one cross-link between two amino acids in the peptide, protein or protein complex that is stable or irreversible in vivo, wherein the at least one cross-link reduces the... Agent:
20120083009 - Rheumatoid arthritis test method and treating method: To evaluate the prognosis of rheumatoid arthritis based on the evaluation of the disease severity of the patient to select a treatment method suitable for each rheumatoid arthritis patients, and to measure HSC71 protein levels of the patients before and after the administrations of therapeutic agents to determine the efficacy... Agent: National University Corporation Chiba University
20120083010 - Method for diagnosing pompe disease: Provided is a method for diagnosing Pompe disease in a patient by measuring acid α-glucosidase activity in a sample from the patient. The invention also provides a method for monitoring the treatment of Pompe disease with specific pharmacological chaperones by measuring acid α-glucosidase activity in a sample from the patient.... Agent:
20120083011 - Sensitive methods for detecting the presence of cancer: Described herein are sensitive methods for determining if a subject has cancer. The methods generally involve quantifying the amount of one or more biomarkers derived from Galectin-3 in a biological sample from the subject by mass spectrometry, wherein an increase in the amount of one or more biomarkers in the... Agent:
20120083012 - Expression system for producing multi-enzyme complexes and uses thereof: An expression system for producing a multi-enzyme complex, the system including a nucleic acid molecule containing a promoter operatively linked to a nucleotide sequence including multiple genes encoding multiple enzymes that are components of the multi-enzyme complex.... Agent: Academia Sinica
20120083013 - Glucosyltransferase specific to position-4 of furofuran-type lignan, and polynucleotide encoding same: The invention provides a polynucleotide encoding a furofuran lignan 4-O-glucosyltransferase, and others. The polynucleotide in accordance with the present invention comprises a polynucleotide consisting of the nucleotide sequence represented by SEQ ID NO: 3 or SEQ ID NO: 5, or a polynucleotide encoding a protein consisting of the amino acid... Agent: Suntory Holdings Limited
20120083014 - Nicotiana benthamiana plants deficient in xylosyltransferase activity: The invention provides Nicotiana benthamiana mutant plants which are incapable of forming xylosyl-structures on glycoproteins. In addition, the invention provides methods for the production of heterologous glycoproteins in said mutant plants.... Agent:
20120083015 - Antibodies against human tweak and uses thereof: An antibody binding to TWEAK comprising as heavy chain variable domain a CDR3H selected from the group consisting of SEQ ID NO: 8, 16 or 24.... Agent:
20120083016 - Method for tracing gram-negative bacteria inside animal model using stable and bioluminescence-based expression system therefor: A method of creating a biotechnological product and an efficient and stable bio-luminescence vector which could be used for tracking Gram-negative bacteria when distributing inside animal body are provided. Through conjugation, this auto-luminescence vector can be easily transmitted from bacteria to bacteria among Gram-negative bacteria, and may facilitate bacteria to... Agent: Chung Gung Medical Foundation, Linkou Branch
20120083017 - Asymmetric adapter library construction: The present invention provides methods and compositions for asymmetrically tagging a nucleic acid fragment using asymmetric adapters.... Agent:
20120083018 - Thermostable dna polymerases and methods of use: Thermostable viral and microbial polymerases exhibiting a combination of activities selected from proofreading (3′-5′) exonuclease activity, nick translating (5′-3′) nuclease activity, synthetic primer-initiated polymerase activity, nick-initiated polymerase activity, reverse transcriptase activity, strand displacement activity, terminal transferase activity, primase activity, and/or efficient incorporation of chain terminating analogs. Some of the polymerases... Agent:
20120083019 - Use of glycoside hydrolase 61 family proteins in processing of cellulose: The invention provides recombinant GH61 proteins obtained from Myceliophtora thermophila, and nucleic acids that encode such proteins. The invention also provides protein fractions isolated from M. thermophila supernatant that have GH61 protein activity. These preparations can be used to increase yield of products from reactions in which a cellulose-containing substrate... Agent: Codexis, Inc.
20120083020 - Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms: Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate, dimethylallyl diphosphate and isoprenoid pathway derived products in the plastids of transgenic plants and microalgae, (2) create novel antibiotic resistant transgenic plants... Agent:
20120083021 - Low odor coating compositions and paints: This invention provides low odor stable coating compositions, and methods of their production. The stable aqueous coating compositions and paints comprise one or more emulsion-polymerized addition polymer and one or more carboxylesterase enzyme having an ester hydrolysis activity in the composition of less than 0.03 micromole/minute, wherein the aqueous coating... Agent:
20120083022 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing in a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor... Agent: Ineos Bio Limited
20120083023 - Microbial oil production from biomass hydrolysate by oleaginous yeast strains: Oleaginous yeast strains are used to hydrolyze biomass (e.g. wheat straw) that has been pretreated using dilute acid, in order to produce lipids. The lipids may be used as feedstock for producing biofuels.... Agent:
20120083024 - Materials and methods for synthesis of a flavor and aroma volatile in plants: The subject invention concerns polynucleotides encoding a plant 2-phenylethanol dehydrogenase enzyme. In one embodiment, the polynucleotide encodes a tomato 2-phenylethanol dehydrogenase. The subject invention also concerns polynucleotides encoding a plant phenylalanine decarboxylase enzyme. In one embodiment, the polynucleotide encodes a tomato phenylalanine decarboxylase. The subject invention also concerns 2-phenylethanol dehydrogenase... Agent:
20120083025 - Hybrid enzymes: The present invention relates to hybrid polypeptides having a first amino acid sequence having endo-amylase activity and a second amino acid sequence having carbohydrate binding activity. The present invention also relates to the use of the hybrid polypeptides in starch processing and baking.... Agent: Novozymes A/s
20120083026 - Method for removing co2 from a smoke or exhaust gas of a combustion process: A method and arrangement for removing CO2 from smoke or exhaust gas of a combustion process in a power plant are provided. The exhaust gases comprising CO2 are fed into a tank in which cellular organisms, such as micro algae, are present, converting the CO2 into biomass when nutrients are... Agent:
20120083027 - Basic protein purification tags from thermophilic bacteria: The invention is related to a method for purification of recombinant proteins using highly basic proteins from thermophilic bacteria as purification tags for use in a cation-exchange chromatography purification step. The basic proteins may be ribosomal proteins. The recombinant proteins are expressed in eukaryotic or prokaryotic host cells. The purification... Agent: Novo Nordisk A/s
20120083028 - Device for fecal occult blood test: A devise for fecal occult blood test comprises a first and a second casings, a sampling portion extending from the first casing, a specimen processing portion, at least a testing portion and a packing cylindrical member. The packing cylindrical member is coupled between the first and second casings when unused... Agent: Taichung Veterans General Hospital
20120083029 - Rotating culture vessel and automatic cell culture apparatus using same: Disclosed is a rotating culture vessel based on a rotating culture technology using an RWV, by which cell seeding, liquid medium exchange, quality control and so on can be automated and degassing can be conducted simultaneously with liquid medium exchange without disturbing the cells under culture. Also disclosed is an... Agent:
20120083030 - Incubator: An incubator comprising: a culture chamber configured to accommodate culture; a dish structure configured to contain a liquid; an ultrasonic vibrator provided in a part of the dish structure, the ultrasonic vibrator configured to atomize the liquid; and a gas-liquid contact structure configured to bring the atomized liquid into contact... Agent: Sanyo Electric Co., Ltd.
20120083031 - Method for tracing gram-negative bacteria inside animal model using stable and bioluminescence-based expression system therefor: A method of creating a biotechnological product and an efficient and stable bio-luminescence vector which could be used for tracking Gram-negative bacteria when distributing inside animal body are provided. Through conjugation, this auto-luminescence vector can be easily transmitted from bacteria to bacteria among Gram-negative bacteria, and may facilitate bacteria to... Agent: Chang Gung Medical Foundation, Linkou Branch
20120083032 - Embryonic stem cell line and method for preparing the same: An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.... Agent: H. Bion Co., Ltd.
20120083033 - Production of transgenic avians using improved retroviral vectors: A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian.... Agent:
20120083034 - Ex host maturation of germline stem cells: Methods are provided for the ex host maturation of immature germline cells into haploid gametes for restoration of fertility in patients in need thereof.... Agent:
20120083035 - Modified cell lines for increasing lentiviral titers: The present disclosure provides a method of modifying cells in order to enhance lentiviral titers, cell lines that are modified and modifying reagents. By mediating individual genes and combination thereof, lentiviral titers may be increased.... Agent: Dharmacon, Inc.
20120083036 - Polysaccharide transferase: The present invention is predicated on the discovery that a polysaccharide transferase purified from barley seedlings can catalyze the formation of covalent bonds between different polysaccharides, including between xyloglucans and cellulose, and between xyloglucans and (1,3;1,4)-β-D-glucans. The present invention thus provides, among other things, an isolated or substantially purified polysaccharide... Agent: Adelaide Research And Innovation Pty Ltd
20120083037 - Non-viral transfection agent: The invention relates to a non-viral transfection agent comprising polymer/nucleic acid complexes and nanofibers, wherein the polymer/nucleic acid complexes are composed of at least one nucleic acid and at least one cationic polymer. The nanofibers carry the polymer/nucleic acid complexes, wherein the non-viral transfection agent is advantageously produced by means... Agent: Philipps Universitat MarburgPrevious industry: Education and demonstration
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