|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology March listing by industry category 03/12Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 03/29/2012 > 93 patent applications in 62 patent subcategories. listing by industry category
20120077182 - Additive solution for blood preservation: A method for the storage of red blood cells provides for mixing an additive solution with packed red blood cells to create a suspension of red blood cells. The method further provides for reducing the oxygen in the suspension of red blood cells; and storing the suspension of red blood... Agent: The Trustees Of Boston University
20120077181 - Method for the cryopreservation of cells, artificial cell constructs or three-dimensional complex tissues assemblies: The cryopreservation of cells and tissue cultures for long term storage of cells, cell constructs or three-dimensional complex tissues assemblies is based on the use of a collagen cell carrier (CCC) having a specific composition and thickness and appropriate mechanical properties which are maintained after thawing. The collagen cell carrier... Agent:
20120077183 - Reaction apparatus: An apparatus 20 for biological or chemical reactions, in particular PCR, includes a heat removal module 22 adapted to receive snugly a reaction vessel 24 in such a manner as to create good thermal conductivity contact between the module and the vessel. The heat removal module 22 is formed of... Agent:
20120077185 - Detection of genetic abnormalities and infectious disease: The present invention provides assay systems and related methods for detecting genetic abnormalities and infectious agents in maternal samples. Exemplary maternal samples for analysis using the assay systems of the invention include maternal blood, plasma or serum.... Agent: Tandem Diagnostics, Inc.
20120077184 - Electromagnetic multiplex assay biosensor: A method is provided for determining the presence of multiple different target analytes in a liquid sample using electrophoretic separation and magnetic labels within a self-contained reaction cartridge and an external magnetic sensor for detection. Magnetic labels are bound to target analytes through specific binding elements. By electrophoretic separation, the... Agent: Starkdx Incorporated
20120077188 - Methods for manipulating liquid substances in multi-chambered receptacles: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included... Agent: Gen-probe Incorporated
20120077187 - Recombinant antigen for detection of toxocariasis: A vector comprising a polynucleotide sequence encoding a polypeptide having an amino acid sequence of SEQ ID NO: 2 for detecting antibody against Toxocara spp. in a biological sample.... Agent:
20120077189 - Scaffold-based polymerase enzyme substrates: The invention provides a novel class of scaffold-based labeled polymerase enzyme substrates. The polymerase enzyme substrates have a multivalent core or scaffold to which is attached fluorescent dye moieties and nucleoside phosphate moities. The polymerase enzyme substrates have multiple fluorescent dye moities and/or multiple nucleoside phosphate moieties. Preferred multivalent cores... Agent: Pacific Biosciences Of California, Inc.
20120077190 - Substrates, systems and methods for analyzing materials: Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in... Agent: Pacific Biosciences Of California, Inc.
20120077186 - Use of cysteine-derived suppressor trnas for non-native amino acid incorporation: Disclosed herein are compositions and methods for incorporating non-native amino acids into a single polypeptide. In one example, an isolated modified suppressor tRNA is disclosed that includes the following: a modified tRNAcys, wherein the tRNAcys has been modified so that an anticodon of the tRNA is complementary to a stop... Agent: Oregon Health & Science University
20120077194 - Apparatus and methods for parallel processing of micro-volume liquid reactions: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays... Agent: Board Of Trustees Of The Leland Stanford Junior University
20120077191 - Genotyping dna: Described herein are compositions and methods useful for the detection of nucleic acid variations. Ligation within a probe or between probes is used to distinguish between probes perfectly complementary to a target and those containing a mismatch. Nucleotide fill-in/extension steps are optionally applied according to the type of assay performed.... Agent: Celula, Inc.
20120077195 - Method for detecting variations in nucleic acid sequences: The present invention relates to a method and a kit for detecting nucleic acid sequence variation using melting curve analysis, especially relates to a method and a kit for detecting nucleic acid sequence variation by melting curve analysis using self-quenched probe. Said method provides the characteristics of the self-quenched probe... Agent: Xiamen University
20120077193 - Method of distinguishing genotypes: The present invention relates to a method of distinguishing genotypes using PCR-PHFA including: a nucleic acid amplification step in which a mutation site-including region of a gene is amplified by a nucleic acid amplification reaction, thereby obtaining an amplification reaction solution; and a distinction step in which the amplification reaction... Agent: Toppan Printing Co., Ltd.
20120077192 - Risk assessment for adverse drug reactions: The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most... Agent: Academia Sinica
20120077198 - Compositions and methods for cancer testing: Methods and compositions which provide a gene expression-based prognostic signature of cancer relapse and prediction of metastatic cancer are described, and in particular methods to predict colorectal cancer (CRC) recurrence and chemosensitivity.... Agent: Ambergen, Inc
20120077199 - Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles: A method provides an index that is indicative of the state of a subject, as to a biological condition, based on a sample from the subject. An embodiment of this method includes: deriving from the sample a profile data set, the profile data set including a plurality of members, each... Agent: Life Technologies Corporation
20120077201 - Methods and compositions for detecting a drug resistant egfr mutant: (b) testing the sample to determine whether the gene encoding EGFR is present in a mutant form that encodes a T790M mutant of EGFR in addition to the somatic gain of function mutation. A finding that the mutant form is present indicates that the cancer has become or will become... Agent: Memorial Sloan-kettering Cancer Center
20120077200 - Primers for diagnosing avellino corneal dystrophy: The present invention relates to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, and more particularly to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, which can accurately diagnose the presence or absence of a mutation in exon 4 of BIGH3 gene,... Agent: Avellino Co., Ltd.
20120077197 - Sample thermal cycling: A sample processing apparatus includes a sample carrier receiving region configured to receive sample carrier carrying one or more samples for processing by the sample processing apparatus, and a thermal control system that controls a thermal cycling of the one or more samples for processing by the sample processing apparatus... Agent: Analogic Corporation
20120077196 - Universal method for selective amplification of mrnas: The invention relates generally to methods for the amplification of ribonucleic acids, including for example messenger ribonucleic acids (mRNAs). In an embodiment, the invention also relates to kits for amplifying ribonucleic acids, including for example mRNAs. In another embodiment, the invention relates to kits comprising the components for performing the... Agent:
20120077202 - Expression of fabp4 and other genes associated with bladder cancer progression: Disclosed are methods for predicting the risk of bladder cancer progression, including death from bladder cancer by determining gene expression levels of FABP4 and MBNL2 or other markers where increased levels correlate with lack of progression of the subject's bladder cancer, and decreased levels correlate with progression or death from... Agent:
20120077204 - Detection of protein translocation by beta-galactosidase reporter fragment complementation: Methods and compositions are provided for detecting molecular translocations, particularly protein translocations within and between sub-cellular compartments, using at least two components that exhibit a localization-dependent difference in complementation activity. In particular, alpha-complementing β-galactosidase fragments are provided. These β-galactosidase reporter fragments display significantly enhanced enzymatic activity when one fragment is... Agent: The Board Of Trustees Of The Leland Stanford Junior University
20120077203 - Reporter gene construct, assay kit and detection method: According to one embodiment, there is provided a reporter gene construct. The reporter gene construct comprises a transcriptional regulatory sequence and a reporter gene that is functionally bound to downstream of the transcriptional regulatory sequence. The reporter gene construct is activated dependently of environment and the reporter gene codes for... Agent:
20120077205 - Method for producing complex of biotin-labeled cypridina (cypridina noctiluca) luciferase with streptoavidin and method for stabilizing the same: The present invention relates to a method for producing Cypridina luciferase labeled with hydrophilic biotin, characterized in that a biotin reagent containing a polyalkylene glycol structure as a spacer is reacted with Cypridina luciferase, and biotin-labeled Cypridina luciferase wherein a sugar chain in Cypridina luciferase has been biotinylated.... Agent:
20120077206 - Rapid microbial detection and antimicrobial susceptibility testing: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.... Agent: Accelr8 Technology Corporation
20120077207 - Cd86 and cd80 receptor competition assays: The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies.... Agent: Bristol-myers Squibb Company
20120077211 - Stable compositions comprising chromogenic compounds and methods of use: Compositions, assays, methods, and kits are disclosed for use in applications that utilize oxidation of a chromogenic electron donor such as diaminobenzidine (DAB) to generate a signal. Applications include, but are not limited to, immunohistochemistry, chromogenic in situ hybridization, Western blots, Northern blots, Southern blots, ELISA assays, and microarray detection.... Agent: Life Technologies Corporation
20120077209 - Protein biomarkers and therapeutic targets for autoimmune and alloimmune diseaes: A method for characterizing the risk a subject will develop an autoimmune and/or alloimmune disease following tissue transplant includes obtaining a biological sample from the subject, wherein the subject has received the tissue transplant determining in the biological sample a level of at least one protein selected from Tables 1-4,... Agent:
20120077208 - Use of carbamoyl phosphate synthetase 1 (cps) as a humoral biomarker for the diagnosis of tumour diseases and chronic inflammatory intestinal diseases: The invention relates to the use of carbamoyl synthetase 1 (CPS 1) as a humoral biomarker in in vitro methods for early diagnosis and detection, progress prognosis, the evaluation of the severity, and the progress evaluation of tumor diseases and chronic inflammatory intestinal diseases.... Agent: B.r.a.h.m.s Gmbh
20120077210 - Measuring g protein coupled receptor activation: The present invention relates to methods and polypeptides for detecting a compound in a sample. In particular, the present invention relates to the use of a cell-free composition comprising at least one G protein coupled receptor embedded in a lipid Mayer which when expressed in a cell the N-terminus of... Agent:
20120077212 - Methods of diagnosing als: The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a blocking agent. After denaturation of the polypeptide, a detecting agent... Agent: Amorfix Life Sciences
20120077213 - Cell culture improvements: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.... Agent: Abbott Laboratories
20120077214 - Systems and methods for predicting response to minoxidil for the treatment of androgenetic alopecia: Methods, processes, systems, and apparatuses are disclosed for predicting minoxidil response in the treatment of androgenetic alopecia based on colorimetric assay.... Agent:
20120077216 - Beta-glucosidase variants: The invention relates to recombinantly produced β-Glucosidase Variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity... Agent: Codexis, Inc.
20120077215 - Methods and compositions for the detection of beta-lactamases: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases, AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10... Agent: Becton, Dickinson And Company
20120077217 - Buffy coat tube and float system and method: A system for separating and axially expanding the buffy coat is provided that includes a flexible sample tube and a rigid separator float. The sample tube has a sidewall with a first cross-sectional inner diameter. The float includes a main body portion and one or more support members protruding from... Agent: Battelle Memorial Institute
20120077220 - Harvested sample preparation personal box and system and method of harvested sample preparation: A harvested sample preparation system includes an operation isolator 3 in which aseptic manipulation is executed, a harvested sample preparation personal box 4 which can be connected with the operation isolator 3 and storing means 5 that stores a plurality of harvested sample preparation personal boxes 4. The harvested sample... Agent:
20120077218 - Sickle confirm modified hemoglobin solubility test: The present invention provides a method for determining sickle-cell zygosity in a subject, comprising: forming a first solution comprising a sample from the subject, a phosphate buffer, a detergent, and a reducing agent; subjecting the first solution to centrifugation to form a second solution and a supernatant; taking a color... Agent: Saint Louis University
20120077219 - Vibrating microplate biosensing for characterising properties or behaviour of biological cells: There is described a method of characterising a property or behaviour of at least one biological cell. The method comprises the steps of: providing a microplate; submerging at least one surface of the microplate in a cell culture medium such that at least one biological cell to be characterised is... Agent:
20120077221 - Detection device and method for detecting analyte: There is provided a detection device that comprises a light source, a light sensor and an at least partially light-transmitting element that supports growth of at least one analyte selected from among fungi and bacteria. The light source, the at least partially light-transmitting element and the light sensor are positioned... Agent: Tangidyne LLC
20120077222 - Method and device for determining the microbiological contamination in an environment: The method comprises providing at least one sampling plate and at least one supporting member in said environment with the supporting member being suitable for detachably receiving the sampling plate; and removing the plate from the supporting member after a period of time such that the microbiological contamination in said... Agent: Laboratorios Ordesa, S.l.
20120077224 - unnatural amino acid incorporation in eukaryotic cells: This disclosure concerns compositions and methods for improving the incorporation of unnatural amino acids (UAAs) into proteins in eukaryotic cells. It is shown herein that mutation of a prokaryotic tRNA synthetase to increase the interaction with the corresponding tRNA anticodon region results in increased UAA incorporation efficiency in mammalian cells.... Agent: The Salk Institute For Biological Studies
20120077223 - Method for single oxygen atom incorporation into peptides: Optimized enzymatic conditions incorporate a single oxygen atom into digested peptides using a peptidase. The incorporation of a single oxygen atom is especially useful for proteolytic 18O labeling in comparative proteomics. The optimized proteolytic 18O labeling minimizes the generation of a mixture of isotopic isoforms of the peptides resulting from... Agent: University Of North Dakota
20120077227 - Expression process: An expression system for the production of a target polypeptide is provided. The expression system comprises an expression cassette comprising an inducible promoter operably linked to DNA encoding the target polypeptide and an expression cassette for over-expression of DNA binding transcriptional regulator protein, comprising a promoter operably linked to DNA... Agent:
20120077225 - Melibiose operon expression system: New vectors expressible in a host comprising the promoter region of the melibiose operon operably linked to a transcriptional unit that includes nucleic acid sequence which is heterologous to the host. The expression of the nucleic acid sequence is controlled by the promoter region of the melibiose operon. The new... Agent:
20120077226 - Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins: A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic... Agent:
20120077228 - Overexpression of aminoacyl-trna synthetases for efficient production of engineered proteins containing amino acid analogues: Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine.... Agent: California Institute Of Technology
20120077229 - Compositions and methods relating to proteins requiring gamma-carboxylation: The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reductase and associated expression control sequences and a nucleic acid molecule encoding a γ-glutamyl... Agent:
20120077230 - Removal of the guanine cap on the 5' terminus of rna: Methods and compositions are provided for efficiently removing a guanine cap from the 5′ end of an RNA using enzymes. Decapped RNA can be used for cloning, sequencing or other RNA manipulations.... Agent: New England Biolabs, Inc.
20120077231 - Thermal microvalves: The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry... Agent: The Regents Of The University Of Michigan
20120077232 - System and method for controlling a fermentation process: A method for controlling a fermentation process includes injecting a mash into a fermenter and injecting a liquid yeast additive into the fermenter. The liquid yeast additive is injected in a closed-loop manner. The method may be used to control the fermentation processes of one or more fermenters operating in... Agent: Rockwell Automation Technologies, Inc.
20120077233 - Dna encoding novel enzyme having d-serine synthase activity, method of producing the enzyme and method of producing d-serine by using the same: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the... Agent: Mitsui Chemicals, Inc.
20120077235 - Chain-selective synthesis of fuel components and chemical feedstocks: A method comprising providing a starting composition comprising a polyunsaturated fatty acid, a polyunsaturated fatty ester, a carboxylate salt of a polyunsaturated fatty acid, a polyunsaturated triglyceride, or a mixture thereof; self-metathesizing the starting composition or cross-metathesizing the starting composition with at least one short-chain olefin in the presence of... Agent:
20120077234 - Method and system for microbial conversion of cellulose to fuel: A method and system are provided for producing biofuel from cellulosic feedstock. In the method, the cellulosic feedstock is pretreated to separate cellulose, hemicellulose, and lignin. Thereafter, the cellulose and hemicellulose are converted into sugars through enzymatic hydrolysis. Then, the sugars are converted into lipids, e.g. triglycerides, through a microbial... Agent:
20120077236 - 3-hydroxypropionic acid and other organic compounds: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.... Agent: Cargill, Incorporated
20120077237 - Biological methods for preparing adipic acid: The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.... Agent: Verdezyne, Inc.
20120077238 - Methods and systems for production of polyhydroxyalkanoate: Several embodiments of the invention relate generally to a system and methods for the treatment of gaseous emissions comprising methane and one or more non-methane compounds that can influence the metabolism of methane-oxidizing microorganisms. In several embodiments, there is provided a system and methods for the treatment of methane emissions... Agent: Newlight Technologies, LLC
20120077240 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing in a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor... Agent: Ineos Bio Limited
20120077239 - Thermophilic organisms for conversion of lignocellulosic biomass to ethanol: Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of Thermoanaerobacterium saccharolyticum with acetate kinase and phosphotransacetylase expression eliminated are disclosed herein. Further, strain ALK1 has been engineered by site directed homologous recombination to knockout both acetic acid and lactic acid production. Continuous culture... Agent:
20120077241 - Ethanologenic bacteria and their use in ethanol production: The invention relates to bacterium that have increased resistance to furfural and methods of preparation. The invention also relates to methods of producing ethanol using the bacterium and corresponding kits.... Agent: University Of Florida Research Foundation, Inc.
20120077242 - Efficient cell-free hydrogen production: Cell-free synthesis of hydrogen from glucose and cellulosic hydrolysates is provided. Bacterial cells are modified to express high levels of (i) active [FeFe] hydrogenase; (ii) ferredoxin; and (iii) ferredoxin-NADP-reductase (FNR). The cells are then lysed and the lysate is combined with substrate during a production phase, where H2 is produced.... Agent:
20120077243 - Closed bioreactor: Single-use closed bioreactors with recirculating exhaust gas that can be operated in an uncontrolled environment are reported for the manufacturing of biological products using genetically modified biological cultures that produces carbon dioxide or that requires carbon dioxide in their metabolic process.... Agent:
20120077244 - System and method for controlling a fermentation process: A method for controlling a fermentation process includes injecting a mash into a fermenter and injecting a liquid ammonia additive into the fermenter. The liquid ammonia additive is injected in a closed-loop manner. The method may be used to control the fermentation processes of one or more fermenters operating in... Agent: Rockwell Automation Technologies, Inc.
20120077245 - Method and device for the electrical treatment of reaction spaces: The invention relates to a method for applying at least one electrical voltage pulse to at least one reaction space by at least partially discharging at least one charge storing unit for storing electrical charges. According to the invention the method comprises applying at least one voltage pulse to a... Agent: Lonza Cologne Gmbh
20120077246 - Methods and devices for capturing circulating tumor cells: A method of capturing a Circulating Tumor Cell (CTC) from a sample includes introducing a sample into a microfluidic device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the... Agent: The Board Of Trustees Of The University Of Illinoi
20120077247 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino acids.... Agent: Xyleco, Inc.
20120077248 - Method for determining crystallization parameters and apparatus for use with the same: The present disclosure provides a method to allow a user to pre-screen numerous crystallization conditions in the crystallization space to identify those conditions with the highest probability of yielding crystals and high quality diffracting crystals. In one embodiment, the dilute solution thermodynamic virial coefficient, termed B, is used to aid... Agent:
20120077249 - Separation of virus and/or protein from nucleic acids by primary amines: A method of purifying biomolecules with an anion exchanger containing a membrane having a surface having a polymer such as a primary or secondary amine ligand formed thereon, such as polyallylamine. The feedstock is introduced to the exchanger in the presence of one or more ionic-modifiers by themselves or in... Agent: Millipore Corporation
20120077250 - Method for culturing photosynthetic microorganisms on microbial cellulose: This invention provides methods for growing and maintaining photosynthetic microorganisms such as algae and cyanobacteria. More specifically, the invention provides methods of cultivation of photosynthetic microorganisms on bacterial cellulose.... Agent: Ut-battelle, LLC
20120077251 - Methods and compositions for targeting heterologous integral membrane proteins to the cyanobacterial plasma membrane: This disclosure pertains to the functional localization of heterologous integral plasma membrane proteins (HIPMPs) lacking cleavable signal sequences into the plasma membrane (PM) of cyanobacterial hosts, e.g., JCC138 (Synechococcus sp. PCC 7002) or an engineered derivative thereof. More specifically, the disclosure provides chimeric integral plasma membrane proteins comprising pseudo leader... Agent: C/o Joule Unlimited Technologies, Inc.
20120077252 - Biological methods for preparing adipic acid: The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.... Agent: Verdezyne, Inc.
20120077253 - Methods and systems for controlled illumination: Embodiments of the present invention relate generally to systems and methods for the collection of solar energy and the use thereof to generate an algal biomass capable of producing biofuels. In one implementation, the specific irradiance (e.g., moles photons per gram per day) is controlled to optimize algal growth and... Agent: Heliae Development, LLC
20120077254 - Method for anaerobic biodegradation of bioplastics: Semicrystalline bioplastic materials are processed by thermally annealing the bioplastic to increase degree of crystallinity in the bioplastic; and anaerobically biodegrading the thermally annealed bioplastic. The thermal annealing may be performed using a commercial annealing oven. The anaerobic biodegradation may be performed in an anaerobic digester, a landfill, or other... Agent:
20120077255 - Process for extracting fatty acids from aqueous biomass in a membrane contactor module: The present invention relates to a new process for extracting fatty acids from aqueous biomass in a membrane contactor module. The present invention also relates to an integrated process combining biomass concentration and/or diafiltration and fatty acid extraction in said membrane contactor module.... Agent: Due Miljo As
20120077256 - Matched pair transistor circuits: An array of sensors arranged in matched pairs of transistors with an output formed on a first transistor and a sensor formed on the second transistor of the matched pair. The matched pairs are arranged such that the second transistor in the matched pair is read through the output of... Agent: Life Technologies Corporation
20120077257 - Cell measurement system: A cell measurement system measures changes of frequency and transepithelial electrical resistance of a tested cell sample. The cell measurement system includes a quartz crystal sensing module, an oscillation module, a periodic wave-generation module, a low-pass filtration module, and a control module. The cell measurement system of the present invention... Agent: Tatung Company
20120077258 - Diagnostic device: A diagnostic device as a first electrode formed by a noble metal that is not attackable by acid, and a second electrode that is formed of silver. The first and second electrodes are at least partially immersed in a nutrient solution contained in a container, into which a tissue sample... Agent:
20120077261 - Device for a membrane assay: Disclosed is a simple device for a membrane assay using the lateral flow immunoassay method, whereby a subject to be detected can be detected at a high sensitivity, provided with, as a label drying pad, a substrate which has a higher tensile strength than glass fiber and can well release... Agent: Denka Seiken Co., Ltd.
20120077259 - Epistem genedrive: We describe a thermal cycler comprising a Peltier-type thermoelectric element used for cooling a sample block, and a non-Peltier-type heating device for heating the sample block. The cycler also includes a heat sink connected to the Peltier-type element by a heat pipe, which permits thermal energy to transfer from the... Agent: Epistem Limited
20120077260 - Reservoir-buffered mixers and remote valve switching for microfluidic devices: The present invention relates generally to the control of fluid flow rate and direction on a microfluidic device. In particular, the present invention provides an integrated valveless microfluidic device, where directional fluid control is controlled using off-chip remote valve switching and fluid flow rate changes are controlled using on-chip flow-rate... Agent: Trustees Of Boston University
20120077262 - Liquid reflux high-speed gene amplification device: e
20120077263 - Methods and materials for isolating exosomes: This document relates to methods and materials involved in obtaining exosomes. For example, methods and materials for obtaining exosomes from biological samples such as urine samples are provided.... Agent: Mayo Foundation For Medical Education And Research
20120077266 - Highly thermostable fluorescent proteins: Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a... Agent: Los Alamos National Security, LLC
20120077264 - Methods for plant transformation using spectinomycin selection: The present invention relates to methods and compositions for transforming soybean, corn, cotton, or canola explants using spectinomycin as a selective agent for transformation of the explants. The method may further comprise treatment of the explants with cytokinin during the transformation and regeneration process.... Agent:
20120077265 - Microrna and methods for inhibiting same: The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a pancreatic islet microRNA. In another embodiment, the invention relates to isolated single stranded pancreatic islet microRNA molecules or anti-pancreatic islet microRNA molecules.... Agent: The Rockefeller University
20120077267 - Device and method of separating cells by using magnetic force: A cell separation device includes a channel or chamber in which a sample flows or moves, the sample including target cells marked with magnetic particles, and non-target cells, and a magnet which generates a magnetic first force in a first direction with respect to the sample within the channel or... Agent: Samsung Electronics Co., Ltd.
20120077268 - Animal-free cell culture method: The present invention relates to a process for culturing animal cells, e.g., human, diploid anchorage-dependent cells, in the absence of exogenous components of primary animal origin. In particular, the invention provides cell culture media substantially free of exogenous components of primary and secondary animal origin which comprises at least one,... Agent: Glaxosmithkline Biologicals, S.a.
20120077269 - Use of a protein in stem cell and cancer applications: The present invention discloses a novel antibody HES5:3:3 directed towards a specific antigen present on human pluripotent stem (hPS) cells and cancer tissue. The antibody can be used as a tool for human pluripotent stem (hPS) cell applications, such as the separation, surface adhesion and enhanced survival of said hPS... Agent: Cellartis Ab
20120077270 - Control of gene expression using a complex of an oligonucleotide and a regulatory peptide: A method for suppressing the expression of a selected gene in a cell, the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an... Agent: Imperial College Innovations Limited
20120077271 - Differentiation of multi-lineage progenitor cells to chondrocytes: Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described, as well as methods of differentiating the progenitor cells into chondrocytes.... Agent:
20120077272 - Cellular scaffold: A cellular scaffold that is suitable for tissue regeneration, cell culture and in vitro assays. The invention relates to a layered cell scaffold that is seeded with mesenchymal and ectodermal cells. The layered cellular scaffold comprises an inoculum of mesenchymal cells and ectodermal cells positioned between two opposing scaffolds in... Agent:
20120077273 - Methods and compositions for limiting viability of a modified host cell outside of designated process conditions: The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.... Agent: Joule Unlimited Technologies, Inc.03/22/2012 > 84 patent applications in 49 patent subcategories. listing by industry category
20120070817 - Acoustic-assisted iterative wave form optimization for deep tissue focusing: A method, apparatus, and article of manufacture for irradiating one or more targets within a sample with electromagnetic (EM) radiation. One or more targets within the sample are controllably defined with an acoustic field. The sample is irradiated with input EM radiation having an input wavefront. An amount of frequency... Agent: California Institute Of Technology
20120070818 - Flow measurement and control for improved quantification of particles in flow cytometry: The present invention relates to methods that enable improved accuracy for quantitative particle counting in a flowing liquid stream. The methods of the present invention utilize the real-time measurement of flow rates and flow rate control through feedback mechanisms to improve quantification, and this improved quantification translates to more accurate... Agent: Indevr, Inc.
20120070819 - Determination of interactions of constant parts of antibodies with fc-gamma receptors: The invention relates to a novel method for the exact determination of the binding of the Fc-part of IgG-antibodies to Fc-gamma receptors, and for the simultaneous examination of the antigen-specificity and the Fc-gamma-receptor activation, as well as specific materials for use in said method. The invention furthermore relates to a... Agent:
20120070821 - Interference control panel for evaluation of analytical assays for samples derived from blood: The invention relates to quality control of analytical assays, particularly NAT assays of blood samples containing nucleic acids. A control panel containing quantified amounts of substances known to interfere with an analytical assay is used and compared with a reference sample in the analytical assay. A comparison of the assay... Agent: Life Technologies Corporation
20120070822 - Method for signal amplification during lateral-flow analysis: Provided is a signal amplifying method in a lateral flow analysis with high sensitivity, in which gold ions and a reductant are added and react to a seed of gold nano particles to amplify a signal, and a lateral flow analysis device using the same.... Agent:
20120070820 - Probes and methods for hepatitis c virus typing using multidimensional probe analysis: This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at least five HCV types (for example, selected from types 1, 2, 3, 4, 5 or 6), or to... Agent: Roche Molecular Systems, Inc.
20120070823 - Method and device for automatically processing a sample: The invention relates to a method and a device for processing a biological sample. According to the invention, the processing comprises binding, washing and eluting biomolecules of the biological sample. The aim of the invention is to provide a method and a device for the automatic processing of biological samples... Agent: Qiagen Gmbh
20120070825 - Novel compounds and derivatizations of dnas and rnas on the nucleobases of pyrimidines for function, structure and therapeutics: Disclosed are compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Also disclosed are methods of preparing compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer.... Agent: Sena Research, Inc.
20120070824 - Thermostable proteinases from thermophilic bacteria: The present invention relates to the preparation of a method for the preparation of nucleic acid samples, including the steps of adding at least one non-specific thermophilic enzyme to a sample containing nucleic acid for testing, and incubating said sample for a preferred period at 65-80° C. as required to... Agent: Zygem Corporation Limited
20120070831 - Amplification of distant nucleic acid targets using engineered primers: The invention is a method of amplifying nucleic acids by synthesizing an engineered amplicon containing the sequence of interest, but omitting intervening sequences present in the template molecule. The method utilizes an “amplicon bridge” incorporated into the amplification primers. The length and content of the desired amplicon can be chosen... Agent: Roche Molecular Systems, Inc.
20120070827 - Detection of fetal cells from maternal blood: The present application relates to methods for identification of foetal cells and generation and isolation of binding members recognising foetal cells. Said methods may further be used for other purposes relating to characterisation of biological samples and biological antigens. The methods are characterised by the applicability in situations where the... Agent:
20120070826 - Lafora's disease gene: A novel gene (EPM2B) that is mutated in humans and dogs with Lafora's disease is described.... Agent: The Hospital For Sick Children
20120070833 - Lateral flow microfluidic assaying device and related method: Provided herein is a microfluidic device and related method for controlling flow of different fluid components of a fluid. The microfluidic device comprises an input channel, focusing channel and an assaying channel. The microfluidic device is adapted to separate a fluid into at least two fluid components, and is further... Agent:
20120070828 - Methods for the detection and identification of extended spectrum beta lactamases: Embodiments disclosed herein relate to compositions for the detection and/or identification of microbes that carry extended spectrum beta-lactamase genes. Specifically, provided herein are oligonucleotides, probes, and kits containing the same, for the detection of bacterial CTX-M sequences. Also provided are methods for the detection and/or amplification of microbes harboring extended... Agent: Geneohm Sciences, Inc.
20120070834 - Screening methods for transfusion related acute lung injury: The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and kits for screening for HNA-3a and HNA-3b specific antibodies, HNA-3a and HNA-3b polypeptides and HNA-3a and HNA-3b nucleic acids... Agent: Ernst-moritz-arndt-universitÄ T Greifswald
20120070832 - Se33 mutations impacting genotype concordance: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout.... Agent: Life Technologies Corporation
20120070829 - Size selection of dna for chromatin analysis: Methods for analyzing chromosomal DNA, including chromatin, are provided.... Agent: Bio-rad Laboratories, Inc.
20120070830 - Stabilization of ozone-labile fluorescent dyes by thiourea: The present invention provides compositions and methods for stabilization of fluorescent dyes. In particular, the present invention provides buffer systems comprising thiourea to protect against degradation of ozone-labile fluorescent dyes.... Agent: Lbis Biosciences, Inc.
20120070842 - Assay for telomerase activity using microfluidic device: Methods for determining the level of telomerase reverse transcriptase activity in mammalian cells are disclosed. A preferred measuring device is a microfluidic device that includes a spectrophotometer, a fluorescent detector, a fluorescence polarization detector or a scintillation counting device.... Agent:
20120070837 - Cip2a as a biomarker in detection of cervical cancer: The present invention provides methods and compositions for detecting cervical cancer in a human. The present invention provides CIP2A as a biomarker detectable in a biological sample from cervix of an individual, an increased expression of same is an indication of cervical cancer in the individual. CIP2A mRNA or protein... Agent: Medical Diagnostic Laboratories, LLC
20120070835 - Method of cloning stable stress tolerant superoxide dismutase using universal primers: The present invention relates to a method of cloning stable stress tolerant superoxide dismutase from diverse plant species using universal primers.... Agent: Council Of Scientific & Industrial Research
20120070836 - Methods of detecting residual amounts of polymers used in the purification of biomolecules: The present invention relates to methods of detecting residual amounts of polymers including stimulus responsive polymers, which are used in processes for purifying biomolecules such as, for example, proteins, polypeptides, antibodies, vaccines and the like.... Agent: Millipore Corporation
20120070841 - Nucleic acid quantification method and microchip for nucleic acid amplification reaction: A nucleic acid quantification method that uses a microchip for nucleic acid amplification reaction, the microchip including an inlet through which a liquid is introduced from outside, a plurality of reaction regions provided as reaction sites of a nucleic acid amplification reaction, and a channel through which the liquid introduced... Agent: Sony Corporation
20120070838 - Polymerase assay with a fret substrate: This specification generally relates to non-radioactive methods of detecting nucleic acid polymerase activity and methods of detecting compounds that modulate nucleic acid polymerase activity. The activity may be measured in real-time using a real-time PCR instrument.... Agent: Life Technologies Corporation
20120070840 - Relative quantification analysis of multi-parametric pcr experiments: An analysis method for quantitative PCR experiments including multiple genes of interest, multiple samples and multiple conditions is provided. For calculating the relative expression status of multiple target genes from multiple samples under multiple different conditions, a calculation method based on up to three different parameters is performed. In addition... Agent:
20120070839 - Soybean event mon89788 and methods for detection thereof: The present invention provides for soybean plant and seed comprising transformation event MON89788 and DNA molecules unique to these events. The invention also provides methods for detecting the presence of these DNA molecules in a sample.... Agent:
20120070843 - Dbc1, a novel native inhibitor of the anti-aging protein sirt1: A novel complex is identified between the NAD-dependent deacetylase, SIRT1 and its novel inhibitor, DBC1. Provided herein are methods to indentify a compound that inhibits the complexation between SIRT1 and DBC1. Exemplary methods comprise contacting either the complexation between DBC1 and SIRT1 with an agent being tested for its ability... Agent: The Trustees Of Columbia University In The City Of New York
20120070844 - Method for quantifying modified peptides: The present invention provides a method for quantifying modified peptides in a sample, the method comprising: (a) obtaining peptides from the sample; (b) adding reference modified peptides to the peptides obtained in step (a) to produce a mixture of peptides and reference modified peptides; (c) carrying out mass spectrometry (MS)... Agent: Queen Mary & Westfield College
20120070845 - Methods, systems and reagents for improved immunodetection: The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which detect the FLAG epitope tag. Fusion proteins comprising the epitope tags, as well as methods of purifying these proteins and kits detecting... Agent: Rockefeller University (the)
20120070847 - Method for detecting and purifying pancreatic beta cells: The invention is based, in part, on the discovery that a polypeptide, referred to herein as Betacam, is selectively expressed on the surface of pancreatic islet cells, Thus, in one aspect, the invention is directed to compositions comprising Betacam or that can be used to detect Betacam. In another aspect,... Agent:
20120070846 - Methods for detecting molecule-molecule interactions with a single detection channel: A single molecule or molecule complex detection method is disclosed in certain aspects, comprising nano- or micro-fluidic channels.... Agent: The Board Of Regents Of The University Of Texas System
20120070849 - Methods and compositions for risk stratification: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in... Agent:
20120070848 - Tumor cell-derived microvesicles: The present invention relates to a method for diagnosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a sample of a subject by detecting oncogenic proteins in microvesicles, and to the use of an agent blocking exchange of microvesicles for... Agent: University Of Toronto
20120070850 - Method for detecting microorganisms and microorganism detecting apparatus: It is possible to determine the presence of bacteria in a sample solution in a shorter period of time without changing a conventional incubating method. Bacteria in a sample solution are incubated in, for example, a sterilized agar medium 10 having a layer thickness of 0.1 μm to 1 μm... Agent: Nihon Dempa Kogyo Co., Ltd.
20120070851 - Antibody specific to methicillin resistant staphylococcus aureus, detection method and kit for methicillin resistant staphylococcus aureus using the same: The present invention relates to an antibody against a protein specifically expressed in methicillin-resistant strains of Staphylococcus aureus (MRSA), and a method and a kit for detecting MRSA. The present invention enables a fast and accurate detection of MRSA by using both a PBP2a-specific antibody for the detection of PBP2a... Agent: Dinona Inc.
20120070852 - Assay: The present invention relates to an assay for transferases. The assay comprises a first moiety comprising a transferase substrate and a second moiety capable of binding to the transferase substrate after it has been acted on by the transferase. One of the first and second moieties comprises a fluorophore and... Agent: Imperial Innovations Limited
20120070854 - Hnrnp a3 related peptides and use thereof for diagnosis of rheumatoid arthritis: The invention relates to a peptide and retro or retro-inverso peptide thereof, with a length of ≦25 amino acid residues, characterized in that the peptide comprises at least one citrulline residue, and exhibits a sequence identity over the whole sequence of the peptide of ≧70% compared to human hnRNP A3... Agent: Charite - Universitatsmedizin Berlin
20120070855 - Method for in vitro assay of soluble fibrin by generating specific degradation products: The invention concerns a method for assaying soluble fibrin in a sample, in which said sample is brought into the presence of a plasminogen activator with a high specificity for soluble fibrin (PA-Fb sp) and the soluble fibrin count in the sample is measured by measuring the difference between the... Agent: Societe Diagnostica-stago
20120070853 - Ykl-40 as a marker for gastrointestinal cancers: The present invention relates to gastrointestinal cancers and methods for selecting a treatment for said gastrointestinal cancer in a subject. The present invention further relates to a methods of diagnosing the presence of and/or classifying the severity of a gastrointestinal cancer; together with methods for determining the effect of a... Agent:
20120070856 - Cross-linking agents: The invention relates to a protein cross-linking agent of the formula, where R1 is an aryl group optionally substituted once or several times by a grouping selected from the group consisting of hydroxy, C1-C4 alkyl, OBoc, SO3Na, Deu, and C1-C4 alkoxy groupings, R2 is N, (III), or (IV), n and... Agent: Universite De Montpellier I
20120070857 - Electrophysiological assays using oocytes that express human enac and the use of phenamil to improve the effect of enac enhancers in assays using membrane potential reporting dyes: In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based... Agent: Senomyx Inc
20120070858 - Method for isolating exosomes from biological solutions using iron oxide nanoparticles: A method for isolating exosomes from blood platelets using superparamagnetic nanoparticles of iron oxide (Fe3O4), by means of a charge attraction mechanism based on the predetermined Zeta potential of the exosomes. The method involves the use of iron oxide nanoparticles that are previously synthesised with a predetermined positive charge, and... Agent:
20120070859 - Bacterial cells, optimized nucleotide sequences and methods for improved expression of recombinant clostridium difficile toxin b: In some embodiments, the present invention provides isolated nucleotide sequences that encode Clostridium difficile toxin B, wherein the isolated nucleotide sequences have been optimized for improved expression of the toxin B in a bacterial cell. Other embodiments of the present invention pertain to methods of expressing recombinant Clostridium difficile toxin... Agent: The Board Of Regents Of The University Of Oklahoma
20120070860 - Combination stirrer: The present patent application describes a stirrer comprising a combination of at least one axially-conveying element and at least one radially-conveying element relative to the rotary shaft of the stirrer wherein the largest diameter of the at least one axially-conveying element is equal to or less than the inner diameter... Agent:
20120070861 - Human lambda light chain mice: Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ sequences from an endogenous mouse κ light chain locus, and mice that express hVλ sequences from a transgene or an... Agent: Regeneron Pharmaceuticals, Inc.
20120070862 - Methods for producing uniquely distinct nucleic acid tags: Disclosed herein are uniquely distinct nucleic acid tags and methods for their use and production. The disclosed tags do not hybridize to a genome of interest and thus can be used as labels without generating background signal associated with unintended hybridization. In one example, tag sequences are derived from a... Agent: Ventana Medical Systems, Inc.
20120070863 - Novel beta-galactoside-alpha2,3-sialyltransferase, a gene encoding thereof, and a method for producing thereof: The present invention provides a novel β-galactoside-α2,3-sialyltransferase and a nucleic acid encoding the sialyltransferase. The present invention also provides a microorganism producing the sialyltransferase, as well as a method for producing the sialyltransferase using such a microorganism. The present invention further provides a vector carrying a nucleic acid encoding the... Agent:
20120070864 - Metal compounds to eliminate nonproductive enzyme adsorption and enhance enzymatic saccharification of lignocellulose: Methods and composition for biofuel processing are provided. For example, in certain aspects methods for using metal compounds to enhance cellulose enzymatic hydrolysis are described. Furthermore, the invention provides integrated processes with fewer lignin removal steps to improve efficiency.... Agent:
20120070865 - Method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.... Agent:
20120070866 - Purified pyrroloquinoline quinone fortified food: Food products fortified by purified PQQ and methods of application and production are disclosed. A method of preserving a food product comprising admixing an effective amount of purified PQQ or a compound containing purified PQQ derivatives with a foodstuff to provide an inhibiting means to microorganism growth in the food... Agent: Shanghai Medical Life Science Research Center, Ltd
20120070867 - process for the enzymatic reduction of enoates: d. R1, R2 and R3 are independently of one another H, —O-C1-C6-alkyl , —O—W with W=a hydroxyl protecting group, C1-C6-alkyl, which can be substituted, C2-C6-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R1, R2 and R3 is a —OH radical, or R1... Agent: Basf Se
20120070870 - Methods and molecules for yield improvement involving metabolic engineering: The invention features methods and compositions relating to cells that have been engineered to reduce or eliminate proteins having enzymatic activity that interfere with the expression of a metabolic product.... Agent: Ginkgo Bioworks
20120070869 - Methods of using nannochloropsis algal strains to produce hydrocarbons and fatty acids: The present invention provides methods and compositions for production of algal-based medium chain fatty acids and hydrocarbons. More specifically, the invention relates to a Nannochloropsis algal strain and mutants that produces high amounts of C16 fatty acids and hydrocarbons. The present invention provides methods and compositions for production of algal-based... Agent:
20120070868 - Production of odd chain fatty acid derivatives in recombinant microbial cells: Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd... Agent: Ls9, Inc.
20120070871 - Polypeptide having d-lactate dehydrogenase activity, polynucleotide encoding the polypeptide, and process for production of d-lactic acid: Highly productive D-lactic acid fermentation uses a transformant obtained by introducing into a host cell a polynucleotide encoding a polypeptide according to any one of the following (A) to (C) in such a manner that the polypeptide is expressed, which polypeptide has a D-lactate dehydrogenase activity higher than those of... Agent: Toray Industries, Inc.
20120070872 - Use of erythromycin as a selective antimicrobial agent in the production of alcohols: A process for the use of low concentration levels of Erythromycin to eliminate or control the growth of unwanted or undesirable bacteria (contaminating bacteria) in the fermentation production of alcohols without inhibition of the growth or replication of the yeast.... Agent:
20120070873 - Method of fixing rail molecule and nano transport device: An object is to move a rail molecule by means of a biomolecular motor deposited on a base and inactivate the biomolecular motor through irradiation with light having a predetermined wavelength, to thereby readily and reliably fix the rail molecule at a predetermined position, while orienting the rail molecule in... Agent: The University Of Tokyo
20120070875 - Amino acid sequences which enhance peptide conjugate solubility: The present invention provides peptide conjugates having improved solubility as well as increased secretion during cell based production, as well as methods of utilizing such peptides. The peptide conjugates include a short peptide domain defined by the amino acid sequence AGIH (SEQ ID NO: 8) and may include a biologically... Agent:
20120070874 - Method for recycling enzyme: In saccharification of cellulose, chimeric β-glucosidase having a region exhibiting thermophilic bacteria-derived β-glucosidase activity and a module combinable to cellulose is used along with cellulosome, and at the completion of saccharification of cellulose, a cellulosic substrate is added to make the chimeric β-glucosidase and cellulosome attach to the cellulosic substrate... Agent: Japan International Research Center For Agricultural Sciences
20120070876 - Variant form of urate oxidase and use thereof: The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.... Agent: Savient Pharmaceuticals, Inc.
20120070877 - Rationally designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent: Duke University
20120070878 - Microporous microfluidic device: A micro fluidic apparatus includes (i) a first conduit; (ii) a second conduit; and (iii) a first interconnected microporous network in communication with the first and second conduits and configured to allow diffusion of gas between the first and second conduits. The microporous network comprises poly(dimethylsiloxane) (PDMS) and prevents flow... Agent:
20120070879 - Microporous microfluidic device: Methods of removing undesired compounds such as antibiotics from a biological sample are provided. The methods use Molecularly Imprinted Polymers (“MIPs”) to remove or inactivate antibiotics in a sample. The methods use MIPS to remove or inactivate compounds such as antibiotics in a cell culture.... Agent: Becton, Dickinson And Company
20120070881 - Bacillus licheniformis chromosome: The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods... Agent: Novozymes, Inc.
20120070880 - Active plastic material in oil: A method is provided of prolonging the shelf life of probiotic lactic-acid producing bacteria formulated in oil, by using a specific moisture absorbing technology.... Agent:
20120070882 - Bioremediation method: A method for enhancing anaerobic reductive dechlorination of a contaminated site includes enriching the site with organic carbon suitable for use as an energy source by dechlorinating bacteria, nitrogen in the form of urea or ammonia, nutrient phosphorus, matter that releases bio-available hydrogen over a relatively short period of time... Agent:
20120070883 - High temperature high pressure microbial reactor: The high temperature/high pressure (HTHP) reactor of the present invention includes a main cylinder, a reversible piston inside the cylinder that divides the main cylinder into a pressurization chamber and a reactor chamber, a thermal jacket, a lid and an end cap. The HTHP reactor of the present invention is... Agent:
20120070884 - System for incubating the contents of a reaction receptacle: An automated analyzer for performing multiple diagnostic assays includes multiple modules in which aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a sample, pre-heating the sample, incubating the sample, performing an analyte isolation procedure, and ascertaining the presence... Agent: Gen-probe Incorporated
20120070885 - Integrated device for analyzing aqueous samples using lipid multilayer gratings: Described is a device comprising lipid multilayer gratings.... Agent: Florida State University Research Foundation
20120070886 - Microfluidic device and method of manufacturing the microfluidic device: A microfluidic device having a substrate with an array of curvilinear cavities. The substrate of the microfluidic device is preferably fabricated of a polymer such as polydimethylsiloxane (PDMS). The microfluidic device is manufactured using a gas expansion molding (GEM) technique.... Agent: University Of Rochester
20120070887 - Cell visualization system for multi-layer cell culture device: The present invention relates generally to a multi-layer system for containing cells in culture, and a system for visualizing cells cultured in the multi-layered system. More specifically, the present invention relates to a multi-layer cell culture device having a specialized bottom plate and a microscope adaptor which can accommodate a... Agent:
20120070888 - Horizontal array bioreactor for conversion of syngas components to liquid products: A membrane supported bioreactor arrangement and method for anaerobic conversion of gas into liquid products including membrane modules having hollow fibers, each of the hollow fibers formed from an asymmetric membrane wall having a porous outer layer defining biopores for retaining a porous biolayer about the outer surface of the... Agent:
20120070889 - Hybrid bioreactor for reduction of capital costs: A bioreactor with first and second containers has translucent sidewalls housing a plurality of planar membranes over which a slurry of water and photosynthetic microorganisms flows. A light collector is mounted adjacent a gap between the first and second containers for receiving incident light and conveying the light through optical... Agent: Ohio University
20120070892 - Dna virus microrna and methods for inhibiting same: The invention relates to isolated nucleic acid molecules comprising the sequence of a human cytomegalovirus microRNA. In another embodiment, the invention relates to single stranded DNA virus microRNA molecules comprising the sequence of a human cytomegalovirus microRNA. The invention also relates to the anti-DNA virus microRNA molecules.... Agent: The Rockefeller University
20120070891 - Inhibition-based high-throughput screen strategy for cell clones: A method for screening cells with high level expression of a target protein is disclosed. The method includes introducing into a plurality of host cells a DNA construct that encodes both a target protein and an inhibitor to an endogenous selectable marker in the host cells, screening host cells harboring... Agent:
20120070890 - Targeted gene modification by parvoviral vectors: This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing.... Agent: University Of Washington
20120070893 - Methods for producing nonadherent avian cell lines: The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the cells... Agent: Vivalis
20120070895 - Method and apparatus for sustaining viability of biological cells on a substrate: A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular... Agent: Ut-battelle, LLC
20120070894 - Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.... Agent: Battelle Energy Alliance, LLC
20120070896 - Method for producing induced pluripotent stem cells and method for culturing the same: [Solving Means] Induced pluripotent stem cells are produced from human somatic cells by co-culturing human somatic cells having a reprogrammed nucleus with human cells as feeder cells. Induced pluripotent stem cells are produced from somatic cells by co-culturing somatic cells having a reprogrammed nucleus with autologous cells as feeder cells.... Agent: Kyoto University
20120070897 - Method for enucleating nucleated erythrocyte, and enucleation inducer: Provided is a factor capable of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time. More particularly, provided are a method of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time by adding a compound derived from proopiomelanocortin (POMC) to... Agent:
20120070898 - Icell: o
20120070899 - Effective vector platform for gene transfer and gene therapy: The invention relates to the discovery that mutations of serine residues of an AAV capsid results in significantly greater transfection efficiency than the wild type AAV2 virus. In one embodiment, the present invention provides a method of improving efficiency of gene transfer and/or gene therapy to a cell by inhibiting... Agent: Cedars-sinai Medical Center
20120070900 - T-dna/protein nano-complexes for plant transformation: A DNA/protein nano-complex for transfecting eukaryotic cells, wherein the nano-complex comprises an expressible nucleotide molecule complexed with a VirD2 protein molecule, and a RecA protein molecule complexed with the nucleotide molecule/VirD2 protein molecule complex. The nucleotide molecule/VirD2 protein molecule/RecA protein molecule complexed may be further complexed to a cell penetrating... Agent: Plantbiosis Ltd.03/15/2012 > 128 patent applications in 80 patent subcategories. listing by industry category
20120064504 - Media solutions and methods for cryopreservation and thawing of in vitro fertilization specimens: A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C, antioxidants, fatty acids to supply the specimens with... Agent: Genx International, Inc.
20120064505 - Measurement of material properties and related methods and compositions: The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable... Agent: Massachusetts Institute Of Technology
20120064508 - Operation and control of v-trough photobioreactor systems: Disclosed herein are photobioreactor systems for high productivity aquaculture or aquafarming for growing of algae or other organisms in an aquatic environment featuring aspects that favor improved growth rates by achieving control over the contents of the growth medium, including carbon source, nitrogen source, and essential trace elements necessary for... Agent: Heliae Development, LLC
20120064506 - Optimized biogas (biomethane) production from anaerobic reactors: An improved process and apparatus for producing biogas having a high methane content from a feed or substrate. Feed material is injected into a reactor having anaerobic microorganisms to form a bulk liquid in the reactor. The oxidation-reduction potential, pH, and temperature of the bulk liquid and the methane, carbon... Agent: Enos Loy Stover
20120064507 - Use of gas void fraction measurement is the closed loop control of a fermentation process: A technique related to a fermentation process; where a signal processor receives a signal containing information about an amount of entrained air in a mixture forming part of a fermentation process in a tank; and determines a level of foam in the tank based at least partly on the amount... Agent: Cidra Corporate Services, Inc.
20120064513 - Cell sensor, and monitoring method using same for the real-time monitoring of cell capacitance: The present invention relates to a cell sensor for real-time monitoring of cell capacitance and a monitoring method using the same, and more particularly, to a cell sensor capable of monitoring an endocytosis process of a biomolecule through a cell surface receptor by attaching a cell between electrodes and then... Agent: Industry-acaddemic Cooperation Foundation, Yonsei University, Of Seoul
20120064511 - Generic buffer for amplification: The present invention relates to a method of amplifying a first and a second target nucleic acid in separate reaction receptacles, wherein said reaction receptacles comprise a solution comprising amplification reagents and oligonucleotides specific for said first or said second target nucleic acid, wherein said solution is the same for... Agent: Roche Molecular Systems, Inc.
20120064512 - Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, variant proteins... Agent: Celera Corportion
20120064514 - Hiv-1-c resistance monitoring: The present invention relates to methods for the evaluation of HIV-1 Subtype C (HIV-1-C) treatment. The methods are based on evaluating molecular events at the HIV-1-C gag-protease-reverse transcriptase (GPRT) resulting in altered therapeutic efficacy of investigated anti-retroviral compounds. The methods rely on providing HIV-1-C GPRT RNA and evaluating a treatment... Agent: Virco Bvba
20120064510 - Kit including target sequence-binding protein and method of detecting target nucleic acid by using the kit: A kit including a target sequence-binding protein and a method of detecting a target nucleic acid by using the kit that may ensure efficient detection of the target nucleic acid in a biological sample are disclosed.... Agent: Samsung Electronics Co., Ltd.
20120064509 - Methods and compositions related thereto for detecting and identifying distinct species of nucleic acids from causative agents: Methods are described herein for detecting and identifying distinct species of nucleic acids, in a single container, for example, from a certain genus of infectious agents or otherwise causative agents comprising, for example, providing a forward PCR primer common to a homologous gene region between the distinct species, and providing... Agent: Medical Diagnostic Laboratories, LLC
20120064517 - Detection of chromatin structure: The present invention provides methods of determining the accessibility of genomic DNA to a DNA modifying agent.... Agent: Bio-rad Laboratories, Inc.
20120064518 - Methods, tip assemblies and kits for introducing material into cells: Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce fluid pressure as a fluid passes through the constriction portion from the channel portion, whereby the tip assemblies form pores in... Agent: Tufts University
20120064516 - Nucleic acid amplifiction reaction apparatus, substrate for nucleic acid amplification reaction apparatus, and nucleic acid amplification reaction method: A nucleic acid amplification reaction apparatus includes: a reaction region formed as a nucleic acid amplification reaction site in the shape of a tapered well of a decreasing horizontal cross sectional area along a light axis direction in which a substance that precipitates in the course of a nucleic acid... Agent: Sony Corporation
20120064519 - System and method for dual-detection of a cellular response: A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor.... Agent:
20120064515 - Method and apparatus to minimize diagnostic and other errors due to transposition of biological specimens among subjects: A method and apparatus for minimizing diagnostic errors due to transposition of biological specimens among subjects provides for independent biometric confirmation that a given specimen is from a given donor. In certain embodiments, a biological specimen confirmation kit comprises a portable and openable case housing components of the kit, at... Agent: Diagnostic Id, LLC
20120064523 - Bioagent detection systems, devices, and methods: The present invention relates to portable systems and devices, and corresponding methods, for detecting bioagents. In particular, the present invention provides systems, devices, and methods that utilize one or more of a sample preparation component, sample analysis component employing broad range primers, and sample detection component.... Agent: Ibis Biosciences, Inc.
20120064521 - Detection of dna hydroxymethylation: Reagents and methods for analysis of DNA hydroxymethylation are provided. Methods comprise modification of hydroxymethylated cytosine residues with a bulky moiety to protect hydroxymethylated positions from cleavage with a DNA endonuclease. For example, methods may comprise contacting DNA with a glucosyltransferase to glucosylate hydroxymethylated DNA positions and digesting the DNA... Agent:
20120064520 - Diagnosis and prognosis of various types of cancers: The present invention provides nucleic acid sequences that are used for identification, classification and diagnosis of specific types of cancers. The nucleic acid sequences can also be used for prognosis evaluation of a subject based on the expression pattern of a biological sample.... Agent:
20120064526 - Kits for and methods of differential staining of cervical cancer cells and/or tissues: Provided are methods and kits for staining cervical cell sample by contacting the cervical cell sample with a Ficus elastics plant extract, staining the cervical cell sample with New Fuchsin, and staining the cervical cell sample with Light Green or Fast Green. Also provided are method of diagnosing a pre-malignant... Agent: Zetiq Technologies Ltd.
20120064525 - Method for collection of nucleic acid derived from mammalian cell, method for analysis of nucleic acid, and kit for collection of feces: A method of recovering a nucleic acid derived from a mammalian cell taken from feces is provided. The nucleic acid is recovered easily even from feces collected in routine health checkups or the like. The nucleic acid of mammalian cell can be recovered more selectively than that from an enterobacterial... Agent: Olympus Corporation
20120064522 - Methods for determining gene-alpha tocopherol interactions: Method for predicting the change in the level of at least one pro-inflammatory cytokine in an individual due to alpha tocopherol supplementation are provided, as well as methods for predicting the response of an individual to alpha tocopherol supplementation, and methods of nutrigenetic screening of an individual.... Agent:
20120064527 - Nucleic acid analysis device, nucleic acid analysis apparatus, and nucleic acid analysis method: The present invention relates to a nucleic acid analysis device in a nucleic acid analysis apparatus, whereby waste of reaction spots on the nucleic acid analysis device is eliminated and leakage of fluorescence excitation light to unobserved nucleic acid measurement regions is minimized. Specifically, the nucleic acid analysis device has... Agent:
20120064524 - Tumor suppressor gene, p47ing3: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.... Agent: The Government Of The Usa As Represented By The Secretary Of The Dep. Of Health And Human Services
20120064533 - assay for detecting vitamin d and antibodies therefor: A molecule which recognises holo-DBP but which does not recognise apo-DBP or has relatively low affinity thereto.... Agent:
20120064534 - Apparatus for processing a biological and/or chemical sample: The present invention is directed to an apparatus for processing at least one biological and/or chemical sample. The apparatus comprises a substrate, temperature control modules and a rotatable platform carrying a magnetic field generator and an optical unit. The present invention is further directed to a system including the apparatus... Agent:
20120064529 - Detection of nucleic acids and proteins: The invention generally relates to methods for detecting a target nucleic acid and a target protein in a single assay.... Agent: Predictive Biosciences, Inc.
20120064536 - Dried and stabilized ready-to-use composition containing nucleic acid polymerization enzymes for molecular biology applications: The present invention relates to a exsiccated or lyophilized composition comprising: a nucleic acid polymerization enzyme and cellobiose, in which the enzyme is stable for a period of time, even at a temperature of up to 55° C. The composition of the invention can also comprise further reagents, such as... Agent: Sentinel Ch S.p.a.
20120064535 - Method of preparing samples containing nucleic acids: The present invention provides a method of preparing a sample enabling efficient recovery of nucleic acids from a biological sample such as stool without requiring a bothersome procedure. The method of preparing a nucleic acid-containing sample of the present invention comprises (A) a step for mixing a biological sample with... Agent: Olympus Corporation
20120064528 - Methods and reagents for quantifying nucleic acid fragmentation and apoptosis (qlm-pcr, cell number qpcr and apoqpcr): A method for quantifying apoptosis in absolute terms in a cellular sample by real-time ligation-mediated PCR, the method comprising: (a) obtaining first control genomic nucleic acid which is apoptotic nucleic acid from a cellular sample that is substantially 100% apoptotic; (b) obtaining test genomic nucleic acid derived from a test... Agent: The Macfarlane Burnet Institute For Medical Research And Public Health Ltd
20120064531 - Modified nucleotide and real-time polymerase reaction using the same: The present invention relates to a modified nucleotide and real-time polymerase reaction using the nucleotide. Specifically, the present invention relates to a fluorescence material linked-nucleotide, a composition for real-time polymerase reaction comprising the nucleotide, an analysis kit and an analysis method. In the present invention, the fluorescence material linked-nucleotide serves... Agent: Korea Institute Of Science And Technology
20120064530 - Sequence amplification with loopable primers: The present disclosure relates to the amplification of target nucleic acid sequences. This can be accomplished via the use of various primers. The use of these primers, as described herein, results in nucleic acid structures that can reduce the amplification of nonspecific hybridization events (such as primer dimerization) while allowing... Agent: Life Technologies Corporation
20120064532 - Use of serum amyloid a gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents: The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.... Agent: Novartis Ag
20120064537 - Use of perfusion decellularized organs for matched recellularization: The invention provides a method for preparing a perfusion based 3D cell culture system, a recellularized matrix culture system, and methods of using the culture system.... Agent: Miromatrix Medical Inc.
20120064538 - Immunochromatography detection of multidrug-resistant staphylococcus and diagnostic kit: This invention provides a immunochromatography detection device that can detect PBP2′ produced specifically by a bacterium of multidrug-resistant staphylococcus with high sensitivity in a simple and rapid manner via immunochromatography detection to determine infection with multidrug-resistant staphylococcus, a diagnostic method using such detection device, and a diagnostic kit comprising such... Agent: Denka Seiken Co., Ltd.
20120064541 - N-glycan core beta-galactosyltransferase and uses thereof: The present invention relates to new galactosyltransferases, nucleic acids encoding them, as well as recombinant vectors, host cells, antibodies, uses and methods relating thereto.... Agent: UniversitÄ T ZÜ Rich
20120064539 - Resistance to auxinic herbicides: The invention provides methods of identifying herbicidal auxins. The invention further provides auxin-herbicide-resistant plants and genes conferring auxin-herbicide resistance. This invention also provides a method of identifying other proteins that bind picolinate auxins from additional plant species. The invention further provides a method to identify the molecular binding site for... Agent: Agrigenetics, Inc.
20120064540 - Resistance to auxinic herbicides: The invention provides methods of identifying herbicidal auxins. The invention further provides auxin-herbicide-resistant plants and genes conferring auxin-herbicide resistance. This invention also provides a method of identifying other proteins that bind picolinate auxins from additional plant species. The invention further provides a method to identify the molecular binding site for... Agent: Agrigenetics, Inc.
20120064545 - Mouse model for pompe disease and methods of use thereof: The present invention provides mouse models for Pompe disease and methods of using the same to test agents that may be effective in the treatment of Pompe disease.... Agent: Amicus Therapeutics, Inc.
20120064542 - Monoclonal antibodies and detection methods for enzymes that confer resistance to 2,4-dichlorophenoxyacetic acid: Described herein are monoclonal antibodies and methods useful for determining and quantitating the presence of AAD-1 (aryloxyalkanoate dioxygenase) enzyme. These monoclonal antibodies are surprisingly well suited for detecting AAD-1 transgenic event gene products in a variety of plants and plant tissues. The invention further provides quantitative and qualitative immunoassays using... Agent: Dow Agrosciences LLC
20120064543 - Method for detecting substance in biological sample: s
20120064546 - Methods for detection of hydrophobic drugs: Methods and reagents are disclosed for pretreating a sample suspected of containing a hydrophobic drug for conducting an assay method for detecting the hydrophobic drug. A combination is provided in a medium that includes the sample, a releasing agent for releasing the hydrophobic drug and the metabolites from endogenous binding... Agent: Siemens Healthcare Diagnostics Inc.
20120064544 - Methods of diagnosing hypophosphatemic disorders: The present invention relates to methods of diagnosing hypophosphatemic disorders.... Agent: Advanced Research And Technology Institute
20120064547 - Diagnostic antibody assay: Novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.... Agent: Probiodrug Ag
20120064549 - Lenalidomide and thalidomide immunoassays: Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and lenalidomide in biological fluids.... Agent:
20120064550 - Method for measurement of equol in biological sample by immunoassay, kit for the measurement, and method for determination of equol production ability of subject: The measurement method of the present invention is characterized in that S-equol is used as at least one antigen selected from the group consisting of a standard antigen used for the preparation of a standard curve and a labeled antigen that competes with equol in a biological sample. The kit... Agent: Eiken Kagaku Kabushiki Kaisha
20120064548 - Novel genes, compositions, kits, and methods for identification, assessment, prevention and therapy of cervical cancer: The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.... Agent: Millennium Pharmaceuticals, Inc.
20120064553 - Blood coagulation time prolonging agent: Provided is a reagent, which prolongs a blood coagulation time sufficiently and enhances an optical change, thereby enabling a correct and high-sensitive blood coagulability test. The present invention provides a blood coagulation time prolonging agent, including, as an active ingredient, a guanidine compound represented by the following formula (1) or... Agent: Sekisui Medical Co., Ltd
20120064551 - Method for the preoperative determination of the intraoperative risk of bleeding of a patient: In order to determine the intraoperative risk of bleeding preoperatively, both the content of fibrin monomer (FM) and the partial thromboplastin time (PTT) are determined in a blood or plasma sample.... Agent:
20120064552 - Using blood clot in microfluidic valving applications: The present invention provides a method of forming a blood-clot microvalve by heating blood in a capillary tube of a microfluidic device. Also described are methods of modulating liquid flow in a capillary tube by forming and removing a blood-clot microvalve.... Agent: California Institute Of Technology
20120064554 - Methods for assaying enzyme activities: The present invention provides compounds and methods for assaying activities of enzymes such as histone deacetylases and histone acetyltransferases. In some embodiments, the methods may be performed in one step. The compounds described herein features peptide-based compounds having at least one blocked lysine or arginine residue which are coupled to... Agent: Promega Corporation
20120064555 - Quantitative analysis of a biological sample of unknown quantity: Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject matter, the level of the analyte of interest in the medium from which the modified specimen was... Agent: Home Access Health Corporation
20120064556 - Lipoprotein lipase assay: The present invention is directed to a method and kit for the measurement of LPL. The method comprises the following steps; administering a dosage of an anti-coagulant to the subject, gathering the biological sample, adding the biological sample to a well of a well plate, adding a first buffer to... Agent: The Research Foundation Of State Universtiy Of New York
20120064557 - Method of identifying metallo-beta-lactamase-producing bacteria: An object of the present invention is to provide a method of identifying metallo-β-lactamase-producing bacteria, particularly, a method of conveniently identifying an IMP or VIM type. According to the present invention, there is provided a method of detecting metallo-β-lactamase-producing bacteria, comprising spotting a compound (I) onto a surface of a... Agent:
20120064558 - Assays for differentiating between ischemic and hemorrhagic stroke in a human patient: Methods are disclosed for rapidly and reliably differentiating between ischemic and hemorrhagic stroke events in a human patient. The methods include obtaining a biological sample, such as blood serum, and analyzing the sample or a derivative thereof by mass spectrometry to measure the amount of one or more targeted proteins... Agent:
20120064559 - Test element, test kit, test device, and test method: According to one embodiment, a test element includes a base, a pair of optical element units, an optical waveguide unit, a detection unit and a holding unit. The base has transparency. The pair of optical element units are arranged away from each other on a major surface of the base.... Agent: Kabushiki Kaisha Toshiba
20120064561 - Activity of fe-s cluster requiring proteins: The present invention is related to a recombinant host cell, in particular a yeast cell, comprising a dihydroxy-acid dehydratase polypeptide. The invention is also related to a recombinant host cell having increased specific activity of the dihydroxy-acid dehydratase polypeptide as a result of increased expression of the polypeptide, modulation of... Agent: Butamax(tm) Advanced Biofuels LLC
20120064563 - Cell-based sensing systems and methods: The present disclosure describes cell-based sensors. Cell-based sensors can comprise cells coupled with a sensor for sensing change of configuration and/or movement of the cells. Such changes of configuration and/or movement of the cells can be sensed through changes to one or more parameters such as electrical, mechanical and/or optical... Agent:
20120064560 - Folding of recombinant proteins via co-expression of archaeal chaperones: The present invention relates to recombinant protein production, and more specifically, to methods for recovery of properly folder bioactive proteins by expressing chaperone genes from extremophilic Archaea, during recombinant protein synthesis in a host cell thereby significantly improving recovery of properly folded bioactive proteins.... Agent:
20120064564 - Microplate-reader with a controlled gas atmosphere, corresponding method and use of same: A microplate reader and method has at least one measuring device and a holding device for accommodating at least one microplate and for positioning samples-containing wells of microplates in relation to the measuring device. The at least one measuring device is used for detecting light emitted by samples in wells... Agent:
20120064562 - Subterranean alternating digester system and method: An alternating anaerobic and aerobic digestion system and method of forming same includes a subterranean enclosure configured to hold organic matter. The enclosure has a plurality of conduits in a bottom surface of the enclosure. The digestion system further includes an irrigation system configured to dispense a liquid from a... Agent: Harvest Power, Inc.
20120064565 - System setup for biological methane potential test: A system setup is disclosed for carrying out a biological methane potential test on a biosample and a system setup is disclosed for measuring biomethane gas in a biogas flow. In at least one embodiment, the system setups include at least one container for chemical irreversible fixation of other gases... Agent: Bioprocess Control Sweden Ab
20120064566 - Multiple phase flow system for detecting and isolating substances: A multiple flow system and method for detecting substances in a fluid is provided. More specifically, a first fluid tube containing a first fluid and a second fluid tube containing a second fluid are coupled to a common fluid tube via a connector, such that alternating discrete compartments of the... Agent: The Curators Of The University Of Missouri
20120064567 - Active micro sieve and methods for biological applications: An active sieve device for the isolation and characterization of bio-analytes is provided, comprising a substrate for supporting the bio-analytes. The substrate comprises a plurality of interconnections and a plurality of regions, each region comprising a hole and at least one electrode embedded in or located on the substrate and... Agent: Imec
20120064568 - Endomannosidases in the modification of glycoproteins in eukaryotes: The present invention generally relates to methods of modifying the glycosylation structures of recombinant proteins expressed in fungi or other lower eukaryotes, to more closely resemble the glycosylation of proteins from higher mammals, in particular humans. The present invention also relates to novel enzymes and, nucleic acids encoding them and,... Agent: Glycofi, Inc.
20120064570 - Novel cell penetrating peptide: According to the present invention, it is possible to provide a novel cell penetrating peptide that transports proteins into cells and/or into nuclei at higher frequency than conventional cell penetrating peptides, and a pharmaceutical containing the peptide.... Agent: Mitsubishi Tanabe Pharma Corporation
20120064569 - Production of attenuated negative stranded rna virus vaccines from cloned nucleotide sequences: Attenuated, recombinant negative stranded RNA viruses suitable for vaccine use are produced from one or more isolated polynucleotide molecules encoding the virus. A recombinant genome or antigenome of the subject virus is modified to encode a mutation within a recombinant protein of the virus at one or more amino acid... Agent:
20120064571 - Zcytor19 polynucleotides, polypeptides, antibodies and methods of use: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor... Agent: Zymogenetics, Inc.
20120064572 - Bacterial virulence factors and uses thereof: The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A/E pathogens. In some embodiments of the invention, these polypeptides and nucleic acid molecules encoding these polypeptides, or portions thereof, are... Agent:
20120064573 - Methods for making proteins containing free cysteine residues: The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form... Agent:
20120064574 - Method for converting lignocellulosic biomass: The present invention aims to develop a pretreatment technology for performing efficient saccharification without losing carbohydrates (in particular, free carbohydrates, starch, xylan, or the like) due to solid-liquid separation and washing steps, as a pretreatment for enzymatic saccharification of a lignocellulosic biomass feedstock (including a lignocellulosic biomass feedstock containing readily... Agent: Incorp Adm Agency, Nat'l Agr & Food Res Org
20120064575 - Chemo-enzymatic approach to the synthesis of pimecrolimus: Processes for preparing pimecrolimus starting from ascomycin, exploiting the selectivity characteristics of the purified enzymatic systems particularly regarding the selective functionalization of the hydroxyl groups present in position 24 and 33 of ascomycin. Such method represents the first example of chemoenzymatic synthesis for preparing pimecrolimus.... Agent:
20120064576 - Method and composition for enhancing efficiency and sensitivity in polymerase chain reaction: Methods and compositions for enhancing reaction efficiency and sensitivity in polymerase chain reaction (PCR) are disclosed.... Agent: Samsung Electronics Co., Ltd.
20120064577 - Mutant t7 polymerases: Provided are mutant polymerases that comprise a deletion of at least four amino acids among the amino acids at positions corresponding to 167-174 of SEQ ID NO:1. Also provided are mutant polymerases having greater resistance to 30 mM NaCl, 7.5 mM phosphate, or 20 μg/ml single stranded DNA than a... Agent: Enzo Biochem, Inc.
20120064578 - Chromosome-based platforms: Artificial chromosomes, including ACes, that have been engineered to contain available sites for site-specific, recombination-directed integration of DNA of interest are provided. These artificial chromosomes provide tractable, efficient and rational engineering of the chromosome for a variety of applications.... Agent:
20120064579 - Altering enzyme balance through fermentation conditions: This present disclosure relates to methods for improved production of proteins from a cell culture, particularly to culture components and conditions that can preferentially increase the expression of proteins produced from genes under the control of xylanase gene promoter sequences. The improved methods can be used for the production of... Agent:
20120064580 - Termite enzymes and uses thereof for in vitro conversion of lignin-containing materials to fermentable products: The disclosure provides isolated nucleic acid molecules derived from the gut of the termite R flavipes, recombinant nucleic acid molecules comprising a vector and an isolated heterologous nucleic acid molecule operably inserted therein, whereby, when transformed into an appropriate host cell system, the heterologous nucleic acid sequence is expressed as... Agent:
20120064581 - Escherichia coli metabolic engineering oxygen independent platform strains and methods of use thereof: The invention provides transgenic Escherichia coli cells comprising a mutation in cydAB gene, and/or cyoABCD gene, and/or cbdAB gene, and/or ygiN gene, wherein the mutation reduces (preferably, but not necessarily, by 100%) the cytochrome oxydase activity of a protein encoded by cydAB gene, and/or cyoABCD gene, and/or cbdAB gene, and/or... Agent: The Regents Of The University Of California
20120064582 - Nucleotide sequences encoding alanine racemase from coryneform: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID... Agent:
20120064583 - High throughput bioprocess apparatus: The invention relates to a multiple bioreactor system comprising a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by, before or after each bioreactor and the source of pressurised fluid such... Agent: Synexa Life Sciences (proprietary) Limited
20120064584 - Buffer composition for catalyzing the preparation of calcitriol or calcifediol and method for preparing calcitriol or calcifediol using same: The present invention relates to a buffer composition for promoting production of calcitriol or calcifediol, and a method for producing calcitriol or calcifediol using the same. More particularly, the present invention relates to a buffer composition for promoting production of calcitriol or calcifediol comprising a metallic compound, an organic solvent,... Agent: Ildong Pharm Co., Ltd.
20120064585 - Increased heterologous fe-s enzyme activity in yeast: Yeast strains were engineered that have increased activity of heterologous proteins that require binding of an Fe—S cluster for their activity. The yeast strains have reduced activity of an endogenous Fe—S protein. Activities of heterologous fungal or plant 2Fe-2S dihydroxy-acid dehydratases and Fe—S propanediol dehydratase reactivase were increased for increased... Agent: Butamaxtm Advanced Biofuels LLC
20120064586 - Multimeric oxidoreductases: The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.... Agent: Danisco US Inc.
20120064587 - Recombinant clostridia that fix co2 and co and uses thereof: The present invention relates a recombinant Clostridium expressing one or more heterologous Wood-Ljungdahl (WL) genes. In particular, the recombinant Clostridium produces a metabolite at an increased level. The present invention also relates to a method for producing a metabolite by the recombinant Clostridium.... Agent: University Of Delaware
20120064588 - Protein complex having activity catalyzing asymmetric oxidation reaction and process for producing the same: A process for producing a cross-linked crystallized protein complex, which comprises: a first step of concentrating a crude protein derived from an animal or plant; a second step of encapsulating the protein in a gel, to thereby allow the protein to undergo air oxidation, and then extracting a protein complex... Agent:
20120064589 - Energy photoconverter for obtaining biofuels: The present invention relates to the design of energy photoconverters which act in a continuous and closed manner for producing biofuels and other products of interest by means of the mass culturing of phytoplankton.... Agent:
20120064590 - Recovery of higher alcohols from dilute aqueous solutions: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation... Agent: Geno, Inc.
20120064591 - Recombinant yeast with improved ethanol tolerance and related methods of use: The present invention provides isolated Elo1 and Mig3 nucleic acid sequences capable of conferring increased ethanol tolerance on recombinant yeast and methods of using same in biofuel production, particularly ethanol production. Methods of bioengineering yeast using the Elo1 and, or, Mig3 nucleic acid sequences are also provided.... Agent: Wisconsin Alumni Research Foundation
20120064592 - Biocatalysts synthesizing deregulated cellulases: Provided are isolated novel Clostridium phytofermentans biocatalysts with deregulated cellulase activity that produce high yields of products. Further provided are methods of using the biocatalysts to degrade organic material and for use in industrial processes.... Agent: Qteros, Inc.
20120064593 - Superantibody synthesis and use in detection, prevention and treatment of disease: Superantibodies having enhanced autophilic, catalytic, and/or membrane-penetrating properties are prepared by affinity-based conjugation of a photoactivatable organic molecule to a target immunoglobulin. The photoactivatable organic molecule bears a chromophoric aromatic hydrocarbon moiety, which has affinity for the immunoglobulin. Upon photolysis, the organic molecule is covalently linked to the immunoglobulin. A... Agent: Innexus Biotechnology International Ltd.
20120064594 - Device and method for treating cells: The present invention relates to a device for treating biological cells in an object, the device comprising: —a single winding coil element; —an electrical generator connected to the single winding coil element, the single winding being configured to be positioned essentially around the object; wherein the electrical generator is configured... Agent: Technische Universiteit Eindhoven
20120064595 - Method for accumulating cells: The cell accumulation device includes the accumulation and cultivation vessel having a first electrode unit 16, an aggregation of the plural number of individual electrodes, allocated on the first substrate and a second electrode unit 17 allocated on the second substrate. The cell accumulation method has 1) a microbead trapping... Agent: Keio University
20120064596 - High-density spot seeding for tissue model formation: A method for making a tissue includes seeding cells at a selected concentration on a support to form a cell spot, incubating the cells to allow the cells to partially attach, rinsing the cells to remove any unattached cells, adding culture medium to enable the cells to proliferate at a... Agent:
20120064597 - Microfluidic mixing and analytical apparatus: Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the... Agent: Micronics, Inc.
20120064598 - Mutation of the parkin gene, compositions, methods and uses: The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.... Agent: Aventis Pharma S.a.
20120064600 - Anti-5t4 antibodies and uses thereof: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.... Agent: Wyeth LLC
20120064599 - Hybridization linkers: The invention provides method of covalently coupling two or more moieties, the method comprising: (a) providing a first moiety having covalently attached thereto (i) at least one first linker comprising a first hybridizable region and (ii) at least one first group capable of forming a covalent bond; (b) providing a... Agent: Oxford Nanopore Technologies Limited
20120064601 - Chromatography membranes for the purification of chiral compounds: Described herein are composite materials and methods of using them for the separation or purification of enantiomers. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a macroporous cross-linked gel, comprising a plurality of macropores, and a plurality... Agent:
20120064602 - Dish detergent comprising bleaching enzymes: Described are compositions and methods that involve using bleaching enzymes in dish detergents. In some preferred embodiments, the bleaching enzyme comprises at least one laccase, while in some alternative preferred embodiments, the bleaching enzyme comprises at least one glucose oxidase suitable for use in dish detergents. In some additional preferred... Agent:
20120064603 - Selective access to cryopreserved samples: Methods and apparatus for selectively accessing a portion of a sterile cryopreserved sample are disclosed. The apparatus may include a container configured to receive the cryopreserved sample and having a first portion and a second portion, a heat sink chamber surrounding the first portion of the container, and a heat... Agent: American Fluoroseal Corporation
20120064604 - Methods for enhancing infectivity of retroviruses: The present invention provides methods for producing retroviruses or viral vectors with enhanced infectivity. The methods entail transfecting a retroviral vector into a packaging cell that has suppressed expression or inhibited enzymatic activity of a parvulin prolyl peptidyl isomerase (parvulin PPIase), and culturing the transfected packaging cell to allow production... Agent:
20120064605 - Anaerobic microbial composition and methods of using same: A microbial composition for concurrent dechlorination of a mixture of chlorinated ethanes and chlorinated ethenes includes a isolated consortium of bioremediative microorganisms comprising strains of microorganism comprising Clostridium, Acetobacterium, Dehalobacter, Bacteroides, and Proteobacteria. The composition may also include Methanomicrobia.... Agent:
20120064606 - Method for producing high concentrate lactic acid bacteria with membrane bioreactor and freeze-dried, lactic acid bacteria powder: The present invention relates to a method for producing lactic acid bacteria of a high concentration continuously using a membrane bioreactor. Specifically, the present invention relates to a method for producing lactic acid bacteria of a high concentration in a membrane bioreactor that comprises the steps of cultivating lactic acid... Agent: Ambio Co., Ltd.
20120064607 - Fermentation on pentose sugars: The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the host cell the ability to convert xylose to xylulose which may be further metabolized by the... Agent: C5 Yeast Company B.v
20120064608 - Method of culturing photosynthetic organisms: The present invention provides cultivation chambers and methods for the cultivation of photosynthetic organisms, particularly algae.... Agent: Mbd Energy Limited
20120064609 - Solubilization of coal or lignocellulose biomass: The present methods deal with the solubilization of coal and lignocellulose biomass using pyrophosphates, polyphosphates, or derivatives thereof.... Agent: Synthetic Genomics, Inc.
20120064610 - Solvent and method for co2 capture from flue gas: The present disclosure describes the efficient use of a catalyst, an enzyme for example, to provide suitable real cyclic capacity to a solvent otherwise limited by its ability to absorb and maintain a high concentration of CO2 captured from flue gas. This invention can apply to non-promoted as well as... Agent: Alstom Technology Ltd
20120064611 - Process for the preparation of (3r)-hydroxybutyl (3r) -hydroxybutyrate by enzymatic enantioselective reduction employing lactobacillus brevis alcohol dehydrogenase: A process for producing a compound which is (3R)-hydroxybutyl(3R)-hydroxybutyrate of formula (I) which process comprises submitting, to enantioselective reduction, a compound of the following formula (II), (III) or (IV).... Agent:
20120064612 - Microfluidic devices for fluid manipulation and analysis: The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare... Agent: Micronics, Inc.
20120064613 - Monitoring methods and apparatus: A device for remote management of patients suffering from heart failure and hypertension can measure one or more biomarker. The device aids in monitoring the efficacy and safety of treatment in such patients.... Agent:
20120064614 - Device for preparing and/or treating a biological sample: The invention relates to a device for preparing and/or treating a biological sample including an assembly (2) of storage chambers (3) and/or reaction chambers intended for receiving a fluid and means arranged to move an amount of fluid from and/or to at least one of the chambers (3) of the... Agent: Biomerieux
20120064616 - Device for measuring an ultra low gas flow: A measuring device is disclosed for measuring an ultra low gas flow, working by the principle of liquid displacement. In at least one embodiment, the measuring device includes at least one cell including a gas inflow device, a gas compartment device with a predefined inner geometric physical volume and active... Agent: Bioprocess Control Sweden Ab
20120064615 - Test element for detecting an analyte in a sample: The invention relates to a test element for detecting at least one analyte in a sample, in particular for detecting at least one metabolite in a bodily fluid. The test element comprises at least one test field with a test field surface. The test field comprises at least one detection... Agent: Roche Diagnostics Operations, Inc.
20120064617 - System and method for continuous fermentation of algae: The present invention is a method for fermentation of algae or algaefaction method. The method includes feeding a hydrocarbon composition into a gasifier and pre-heating a biomass stream from a fermentation reactor. The biomass stream includes a liquid portion, a catalyst, and a biomass solids portion ranging between 15-92% by... Agent: Missing Link Technologies, L.L.C.
20120064618 - Compost tea apparatus: An apparatus and method of producing compost tea with an elongated container having a vortex chamber, cylindrical screen, and outlet wherein compost is placed inside the vortex chamber, nozzles spray water into the compost chamber under pressure forcing nutrients and micro-organisms from the compost into the water which passes through... Agent:
20120064619 - Device for the anaerobic fermentation of organic material: A device for implementing anaerobic fermentation having a vertically standing fermentation tank with a fermentation chamber in which organic material can be fermented, a feed device to mix fresh organic material with inoculant and to carry it through to an inlet in the fermentation tank, which is also provided with... Agent:
20120064620 - Modular dna-binding domains and methods of use: The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specifically recognized by a polypeptide... Agent:
20120064621 - Cell culture compositions capable of producing a vegf-binding fusion polypeptide: The present invention provided cell culture compositions capable of producing fusion polypeptides that bind vascular endothelial growth factor (VEGF). The cell culture compositions of the invention comprise cells which contain an expression vector comprising a nucleic acid molecule encoding a fusion polypeptide that binds VEGF. The fusion polypeptides may comprise... Agent: Regeneron Pharmaceuticals, Inc.
20120064622 - Methods and systems for chemoautotrophic production of organic compounds: The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products... Agent: Ginkgo Bioworks
20120064623 - Process for the culturing of cells: The invention relates to a process for the culturing of cells, preferably El-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to... Agent: DsmIPAssets B.v.
20120064624 - Method for inhibiting the growth of mycobacterium tuberculosis by using cd13 receptor: The present invention discloses a method for inhibiting the growth of Mycobacterium tuberculosis, comprising: administering at least one selective binding agent such as an anti-CD13 antibody or a CD13 antagonist which can bind a CD13 receptor of a cell to inhibit infection of Mycobacterium tuberculosis. Administration of anti-CD13 antibody can... Agent: Mackay Memorial Hospital
20120064626 - B7-h7 antibodies and method of use: The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.... Agent: Mayo Foundation For Medical Education And Research
20120064625 - Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in... Agent:
20120064627 - Apparatus and method for culturing stem cells: A method is provided to prepare a plurality of microwells suitable for the formation of embryoid bodies from embryonic stem cells. The method requires applying an image-forming material to a heat sensitive thermoplastic material in a designed pattern and heating the material under conditions that reduce the size of the... Agent: The Regents Of The University Of California
20120064628 - Tubular scaffold for neural growth: A scaffold for neurons consists of tubes sized to promote neural growth through the tubes. The tubes may be fixed to a substrate providing electrical or optical paths out from the interior of the tubes from sensors or stimulating probes at one or more locations along the length of the... Agent:
20120064629 - Variant isoprenoid producing enzymes and uses thereof: This disclosure provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present disclosure provides methods of generating polypeptide variants, for example, variant isoprenoid synthases and/or variant prenyl transferases that have at least one desired property not present in the parent polypeptide.... Agent: Shapphire Energy, Inc.
20120064630 - Eukaryotic host cell comprising an expression enhancer: Invention relates to a eukaryotic host cell comprising a recombinant nucleotide sequence encoding an expression enhancer, which is selected from the group consisting of cLC52, RPL33 and cLC61, and its use in a method of producing a protein of interest (POI).... Agent: Fh Campus Wien
20120064631 - Method for amplification and high-level expression of target gene in mammalian cell, and kit for achieving the method: The present invention provides novel means for amplifying a target gene outside a chromosome of the mammalian cell with a high probability in amplifying a target gene with use of IR/MAR plasmid, to further improve a high-level gene amplification system. The present invention is a method of amplifying a target... Agent: Hiroshima University03/08/2012 > 104 patent applications in 65 patent subcategories. listing by industry category
20120058460 - Slug control during thermal cycling: The present invention, in one aspect, provides methods and systems for controlling slugs using temperature dependent fluorescent dyes. In some embodiments, the present invention uses one or more techniques to enhance the visibility of slugs, enhance a system's ability to differentiate between slugs, and enhance a system's ability to identify... Agent: Canon U.s. Life Sciences, Inc.
20120058464 - Assay methods using array of test zones: A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible... Agent:
20120058466 - Differential immunoassay for prrs vaccine antibody: The present invention relates to immunoassays for serologically differentiating animals naturally infected with PRRS virus from animals vaccinated against PRRS. The immunoassays provide detection of at least a portion of the N terminal region of the 2b portion of PRRSV. The immunoassay is preferably an enzyme-linked immunosorbent assay (ELISA).... Agent: Iowa State University Research Foundation, Inc.
20120058463 - Hydrophobic, functionalized particles: The present invention relates to a stable mixture comprising surface-modified particles which are obtained by reacting metal oxide or semimetal oxide particles with at least one compound selected from among silicon-comprising compounds bearing one, two or three alkoxy radicals and at least one solvent, at least one surface-active substance or... Agent: Basf Se
20120058465 - Method and device for assay: A device for assay can evenly develop solution, and performs highly accurate and sensitive measurement. A first device part (10) maintains a second insoluble carrier (12) and a third insoluble carrier (13) in such a manner that they overlap with each other at a detection portion (14) of a first... Agent: Fujifilm Corporation
20120058461 - Molecular detection of xmrv infection: The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus (“XMRV”) and diseases associated with XMRV infection. In particular, the invention relates to XMRV-related nucleic acids having significant diagnostic and screening utilities and methods of using the same.... Agent: Abbott Laboratories
20120058462 - Molecular detection of xmrv infection: The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus (“XMRV”) and diseases associated with XMRV infection. In particular, the invention relates to XMRV-related nucleic acids having significant diagnostic and screening utilities and methods of using the same.... Agent: Abbott Laboratories
20120058468 - Adaptors for nucleic acid constructs in transmembrane sequencing: The invention relates to adaptors for sequencing nucleic acids. The adaptors may be used to generate single stranded constructs of nucleic acid for sequencing purposes. Such constructs may contain both strands from a double stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) template. The invention also relates to the constructs... Agent: Oxford Nanopore Technolgies Limited
20120058467 - Apparatus and method for detecting dna damage: The invention relates to an apparatus and an in-situ method for detecting cellular DNA damage. The invention is particularly suited for use in Comet assays and for automation of such assays. The apparatus comprises a multiwell plate, the plate comprising an array of wells held in fixed relationship with each... Agent: Ge Healthcare Uk Limited
20120058470 - Electrical wiring of polynucleotides for nanoelectronic applications: The present invention relates to incorporation and patterning of polynucleotide molecular wires onto surfaces. In one embodiment, two or more thiol-modified polynucleotide anchors are separately attached to metal contacts that are in turn separately attached to a substrate. Each polynucleotide anchor contains an unpaired region of bases that when bound... Agent: University Of Southern California
20120058469 - Functionalized cyanine dyes (peg): The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes... Agent: Pacific Biosciences Of California, Inc.
20120058475 - Detection of chromosomal inversions: A method and a kit for the identification of chromosomal inversions is described. Chromosomal inversions are difficult to detect unless they are quite large. The improved ability to detect chromosomal inversions is important to a number of medical applications, such as cancer and birth defects, as examples. Reporter species are... Agent: Colorado State University Research Foundation
20120058471 - Identification of nucleic acid sequences: The invention provides a method for use in the detection of a target nucleic acid comprising the steps of: (i) contacting a single-stranded probe nucleic acid with a sample of interest under conditions effective to generate a probe/target nucleic acid duplex by specific hybridisation of said probe nucleic acid to... Agent: University Of Strathclyde
20120058472 - Method and system for nucleic acid detection using electroconductive or electrochemically active labels: A method for electrochemically or electrically detecting nucleic acids, utilizes electrochemically active or electrically conductive reporter materials. An electric voltage is applied and electric signals are measured to the electrodes that are suitable for detecting or quantifying the nucleic acid(s) in a sample. This technique is suitable for point-of-use applications,... Agent: The Hong Kong University Of Science And Technology
20120058476 - Method of oligonucleotide labeling using cycloaddition reaction: The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The... Agent:
20120058473 - Molecular adaptors for dye conjugates: In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an adaptor moiety. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an adaptor. An adaptor can be a component of a linker. These conjugates find use in single... Agent: Pacific Biosciences Of California, Inc.
20120058474 - Probe-antiprobe compositions and methods for dna or rna detection: The invention provides novel compositions and methods for detecting unlabeled nucleic acid targets using labeled polynucleotide probes and partially complementary antiprobes. The interaction of probes, antiprobes and targets result in signaling changes that indicate target frequency. This novel detection mechanism is called a DNA detection switch, and it enable end-point... Agent: Genetag Technology, Inc.
20120058480 - Antigenic approach to the detection and isolation of microparticles associated with fetal dna: The present disclosure provides methods of quantifying and isolating microparticles of fetal from maternal bodily fluids such as cell free maternal plasma. Antibodies or combinations of antibodies that selectively bind fetal microparticles in maternal bodily fluid permit quantification by flow cytometry and isolation through flow cytometry based sorting and immunopurification.... Agent:
20120058482 - Functionalized cyanine dyes (peg): The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes... Agent: Pacific Biosciences Of California, Inc.
20120058486 - Genetic risk assessment technology for epithelial cancer involving gene-environment interaction between ercc5 and tobacco use: Methods and compositions for assessing ERCC5 gene expression in view of certain environmental exposures and determining the risk of an individual for developing one or more epithelial cancers are provided.... Agent: President And Fellows Of Harvard College
20120058477 - Method for detecting the expression of cyclin b2 gene by real-time quantitative pcr: A method and a kit for quantitative detection of the expression of cyclin B2 gene in blood samples, especially in serum.... Agent:
20120058484 - Methods and materials for assessing a mammal's susceptibility for venous thromboembolism: This document provides methods and materials involved in assessing a mammal (e.g., a human) for a susceptibility to develop venous thromboembolism. For example, methods and materials for using a genetic variation in an ABO nucleic acid (e.g., rs2519093) to assess an individual's risk for developing venous thromboembolism are provided.... Agent:
20120058483 - Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers: Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection, diagnosis and progression of prostate cancer, sun exposure and non-melonoma skin cancer are provided.... Agent: Mitomics Inc.
20120058478 - Multimers of s. solfataricus single-stranded dna-binding protein and methods of use thereof: The invention provides multimers of S. solfataricus ssDNA binding protein that bind single stranded DNA. The multimers are robust and stable reagents for use in PCR and other techniques for engineering DNA. The invention further provides methods for performing nucleic acid amplification and engineering using the multimers.... Agent: Regents Of The University Of California
20120058481 - Quantitative real time pcr assay using fret dual-labeled primers: This specification generally relates to non-radioactive methods of non-radioactive real-time PCR using FRET dual-labeled primers.... Agent: Life Technologies Corporation
20120058485 - Rapid and comprehensive identification of prokaryotic organisms (continuation): An improved method for rapid identification of microorganisms is disclosed, along with sequences of PCR primers optimized for this purpose. The primers are designed based on information analysis of sequences from a large number of organism to amplify certain segments of genomic DNA whose sequences are unique among different organisms.... Agent:
20120058479 - Workflow timing between modules: The invention relates to a method of isolating and analyzing an analyte using an analytical apparatus which comprises modules of different types, wherein any one module of one type has a specific, pre-defined timing for carrying out its workflow.... Agent: Roche Molecular Systems, Inc.
20120058487 - Compositions and methods for detecting klebsiella pneumoniae: Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial, fungal and parasitical... Agent:
20120058488 - Wireless based marine pathogens detection system: Embodiments of the present Invention provide antibody functionalized high electron mobility transistor (HEMT) devices for marine or freshwater pathogen sensing. In one embodiment, the marine pathogen can be Perkinsus marinus. A sensing unit can include a wireless transmitter fabricated on the HEMT. The sensing unit allows testing in areas without... Agent: University Of Florida Research Foundation Inc.
20120058491 - Method for induction of differentiation of es cell: It is an object of the present invention to establish a system for reliably differentiating an ES cell into a hepatic cell. The present invention provides a method for inducing the differentiation of an ES cell into a hepatic cell, which comprises, in the presence of an M15 cell, culturing... Agent: Kumamoto University
20120058492 - Method and a kit to detect malignant tumors and provide a prognosis: A method and kit is provided to quantifying and qualifying exosomes in human cell derived samples or in body fluid based on expression of TM9-superfamily proteins on the exosomes. Furthermore, a method and a kit to diagnose malignant tumors is provided. The disclosure also provides a method to monitor tumor... Agent: Hansabiomed Ou
20120058493 - Biomarker for monitoring patients: The present invention is in the field of immunotherapy and relates to methods for determining the efficacy of certain immunotherapy treatments. The methods of the invention include measuring special biomarker at some time following the initiation of immunotherapy treatment to evaluate the clinical outcome of the said treatment. The invention... Agent:
20120058494 - Quenched dendrimeric dyes for florescence detection: The present invention presents designs for high extinction quenched “dyedrons” that can be activated by conversion of a single acceptor/quencher in the molecular assembly to a fluorescent state. The quencher is activated by noncovalent binding to a unique complementary expressible fluorogen activating peptide (FAP). In this way, the quencher serves... Agent: Carnegie Mellon University
20120058490 - Method for detecting an antigen: Provided is a method for detecting an antigen without use of a labeled-antibody. A support having an antibody and a multi-copper oxidase CueO immobilized thereon is brought into contact with a first buffer solution containing the antigen, a current is measured by a potentiostat method using the support and a... Agent: Panasonic Corporation
20120058489 - Use of megalin in urine as marker for detecting renal disorder: This invention provides a simple means for detecting a renal disorder, a diagnostic marker for a renal disorder that enables prognostic prediction of a renal disorder (e.g., diabetic nephropathy and IgA nephropathy) and evaluation of the degree of nephropathy at the phase of stage-II diabetic nephropathy by measuring the megalin... Agent: Juntendo Educational Foundation
20120058498 - Compositions and methods for characterizing arthritic conditions: The present invention relates to autoantibodies against 14-3-3 proteins or circulating immune complexes thereof and the detection of such for the diagnosis and prognosis of an arthritic condition.... Agent:
20120058497 - Diagnostic reagent for crohn's disease: The present invention provides a reagent and a method of safely, conveniently, and specifically diagnosing Crohn's disease. Provided are a diagnostic method for Crohn's disease in a subject, including measuring antibodies against one kind or more of dietary components selected from the group consisting of grapefruit, alfalfa, avocado, cabbage, green... Agent: Ajinomoto Co., Inc.
20120058496 - Physiologically active substance collecting device and biological information acquisition method: A physiologically active substance collecting device, includes: a collecting section brought into contact with a body surface of a living organism to acquire a physiologically active substance from the body surface; and a liquid sending means for sending a solvent to the collecting section, the collecting section having an aperture... Agent: Sony Corporation
20120058495 - Recombinant fragments and synthetic peptides of 17-kda polypeptide useful in detecting bartonella henselae: The present disclosure describes recombinant and synthetic polypeptides of Bartonella henselae and related methods and kits for the detection of antibodies specific for Bartonella henselae. The 17-kDa polypeptides, methods and kits are useful in the detection of recent and/or ongoing infections with Bartonella henselae, which can be useful in the... Agent:
20120058499 - Bioluminescent detection of protease activity: Methods for bioluminescent detection of the activity of proteolytic enzymes including ubiquitin (Ub) and ubiquitin-like (Ubl) proteolytic enzymes are disclosed.... Agent:
20120058500 - Platelet aggregation using a microfluidics device: A microfluidics device to provide real time monitoring of platelet aggregation of a biological sample obtained from a subject. The device comprises a channel configured for passage of the biological sample, the channel comprising a protrusion configured to induce an upstream region of shear acceleration coupled to a downstream region... Agent: Monash University
20120058501 - Oxidized glutathione assay: The present invention provides an assay for detection of oxidized glutathione (GSSG).... Agent:
20120058502 - Method for identifying protease inhibitors: The invention describes a method for assaying HCV NS3 protease activity using an NS3•4A protease molecule. The invention also provides a method for screening and identifying modulators of NS3 protease.... Agent: Vertex Pharmaceuticals Incorporated
20120058503 - Novel indicator platform: A novel indicator platform comprises a plurality of 1H-lndol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class... Agent: Biosynth Ag
20120058505 - Cytosolic delivery of materials with endosome-disrupting colloids: A facile procedure to deliver nanocrystals to the cytosol of live cells that is both rapid and general. The technique employs a unique cationic core-shell polymer colloid that directs nanocrystals to the cytosol of living cells within a few hours of incubation. The present methods and compositions enable a host... Agent: The Regents Of The University Of California
20120058504 - Methods and apparatus for dielectrophoretic shuttling and measurement of single cells or other particles in microfluidic chips: The invention relates to a microfluidic device. The microfluidic device comprises a fluid chamber comprising a particle retention region for retaining at least one particle, such as a cell. The microfluidic device also comprises a plurality of electrodes extending into the particle retention region for applying a dielectrophoretic (DEP) force... Agent: Simon Fraser University
20120058506 - Microneedle: The application relates to microfluidic needles and their manufacturing methods. The microfluidic needle comprises an interface portion containing at least one fluid communication channel, an elongated needle portion (40) projecting away from the interface portion (44), the needle portion having a tip and sidewalls connecting the tip to the interface... Agent: Teknologian Tutkimuskeskus Vtt
20120058507 - Clonal derivation and cell culture quality control screening methods: The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.... Agent: Sru Biosystems, Inc.
20120058508 - Detector for chemical compounds: Systems and methods to analyze contaminants including a plurality of stages configured to detect contaminants in a sample, wherein the plurality of stages are configured to detect a plurality of contaminants at substantially the same time.... Agent:
20120058509 - Apparatus and method for affixing frozen tissue sections to glass or membrane microscope slides: This invention is an apparatus and method for affixing frozen tissue sections to microscope slides. It has three elements; teasing implements, an affixing block and a heating element. The elements are used inside a cryostat prior to processing for molecular biology procedures such as immunohistochemistry or laser micro dissection. The... Agent:
20120058510 - Enzyme complex from trichoderma reesei and p. funiculosum enzymes: The invention relates to an improved enzyme complex having a plurality of enzyme activities of an expression product obtained by fermentation of the genus Trichoderma in combination with one or more enzymes of a different fungus strain.... Agent: Danisco A/s
20120058512 - Method of expressing foreign protein in plastids: The present invention relates to a method of expressing a foreign protein in the plastid of a host cell and secreting said protein into the cytoplasm of the host cell comprising the steps of making a construct of vector linked to a coding sequence of the fusion protein comprising of... Agent:
20120058511 - Mutant microorganism and method for producing peptide using the same: e
20120058513 - Method for producing human recombinant insulin: The invention relates to biotechnology and can be used for producing human recombinant insulin for preparing medicinal agents for the treatment of pancreatic diabetes. A variety of recombinant plasmid DNAs which contain an artificial gene and encode the human insulin precursor is proposed. The biosynthesis of a hybrid polypeptide is... Agent: Limited Liability Company < < Mako> >
20120058514 - Cold active enzyme and method thereof: The objective of the present invention is to obtain a low temperature producing enzyme and more particularly, the enzyme provides a bifunctional purpose of varying its enzyme activity into activity of another enzyme. The present invention has overcome problems such as ability of obtaining an enzyme at low temperature.... Agent: University Putra Malaysia
20120058520 - Method for synthesis of double-stranded dna corresponding to rna, and method for amplification of the dna: An object of the present invention is to provide an inexpensive and simple method for synthesis of a double-stranded DNA corresponding to a particular RNA, and a method for amplification of the aforementioned double-stranded DNA. The present invention relates to a method for synthesis of a double-stranded DNA having a... Agent: Wako Pure Chemical Industries, Ltd.
20120058515 - Method of regulating oligonucleotide functionality: The present invention relates generally to a method of regulating oligonucleotide functionality and, more particularly, to a method of regulating the functionality of a primer or probe. The method of the invention is designed to provide a means to selectively inactivate or activate the functionality of an oligonucleotide, such as... Agent: Monoquant Pty Ltd
20120058519 - Method, devices, and systems for fluid mixing and chip interface: In one aspect, the present invention provides methods, devices, and systems for ensuring that multiple components of a mixture are fully mixed in a continuous flow microfluidic system while ensuring that mixing between segments flowing through the chip is minimized. In some embodiments, the present invention includes mixing fluids in... Agent: Canon U.s. Life Sciences, Inc.
20120058518 - Nucleic acid isothermal amplification method: A nucleic acid isothermal amplification method includes: performing a reverse transcription reaction to reverse-transcribe a target RNA strand into a template DNA strand; irradiating a reaction solution with light to dissociate a photodegradable protecting group bound to a nucleotide in a sequence of an oligonucleotide primer; and performing an amplification... Agent: Sony Corporation
20120058517 - Recombinase polymerase amplification: This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling... Agent: Alere San Diego, Inc.
20120058516 - Sealing multiwell plates: The present invention relates to a heat sealable member comprising a sheet of heat sealable material to a multiwell plate, wherein the sheet is mounted in a frame, and wherein said frame is sized to fit over a multiwell plate so that the sheet is contacted with at least one... Agent: 4titude Limited
20120058521 - Enzymatic oligonucleotide pre-adenylation: Methods and compositions for making and using pre-adenylated oligonucleotide sequences are provided.... Agent: President And Fellows Of Harvard College
20120058522 - Adenoviral va1 pol iii expression system for rnai expression: An adenoviral VA1 Pol III expression system for RNAi expression is provided.... Agent: City Of Hope
20120058523 - Tempering of cellulosic biomass: The present invention is directed to improved systems and methods for reducing costs and increasing yields of cellulosic ethanol. In particular, the present invention provides plants genetically transformed for increased biomass, expression of lignocellulolytic enzyme polypeptides, and/or simplification of harvesting and downstream processing. Also provided are methods for processing biomass... Agent: Edenspace Systems Corporation
20120058524 - Methods for increasing the yield of fermentable sugars from plant stover: Methods for increasing yield of fermentable sugars from plant stover are provided. The methods include using plants homozygous for two brown midrib mutations, bm1 and bm3. The methods also include using plants homozygous for a mutation in a gene that results in reduced cinnamyl alcohol dehydrogenase activity, and a mutation... Agent: Purdue Research Foundation
20120058527 - Cal a-related acyltransferases and methods of use, thereof: Compositions and methods relating to lipase/acyltransferase enzymes identified in prokaryotes and eukaryotes are described. These enzymes can be used in such applications as lipid stain removal from fabrics and hard surfaces and chemical synthesis reactions.... Agent: Danisco US Inc.
20120058525 - Method for producing oil by yeast: A method for producing oil by using yeast is provided. The method comprises utilizing at least one yeast strain serving as a working microorganism to produce the oil, wherein the yeast strain is genus Pseudozyma.... Agent: Fu Jen Catholic University
20120058526 - Methods and systems for processing sugar mixtures and resultant compositions: A method including: (a) selectively reacting a first sugar in a mixture which includes at least one second sugar to form a product mixture comprising a product of said first sugar; (b) separating said product of said first sugar from said product mixture; and (c) separating at least one of... Agent: Hcl Cleantech Ltd
20120058528 - Homolactic fermentation from pentose: Provided is a lactic acid bacterium capable of homolactic fermentation using a pentose as a substrate, the lactic acid bacterium utilizing a pentose, and in which a phosphoketolase pathway is blocked and a pentose phosphate pathway is activated. Also provided is a method for producing lactic acid from a pentose... Agent: Kansai Chemical Engineering Co., Ltd.
20120058529 - Method for highly efficient production of lactic acid using candida utilis: There is disclosed a yeast strain of Candida utilis, wherein the yeast strain has been transformed with at least one copy of a gene that is operatively linked to a promoter sequence enabling expression of the gene and encodes a polypeptide having activity of lactate dehydrogenase. The yeast strain is... Agent: Kirin Holdings Kabushiki Kaisha
20120058530 - Engineering the pathway for succinate production: This invention relates to the biocatalysts for the efficient production of succinic acid and/or other products from renewable biological feedstocks. The biocatalysts have a very high efficiency for the growth-coupled production of succinic acid and/or other products from carbohydrate feed stocks as a result of both genetic manipulations and metabolic... Agent: University Of Florida Research Foundation Inc.
20120058532 - Engineered microorganisms capable of producing target compounds under anaerobic conditions: The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH... Agent: Gevo, Inc.
20120058533 - Recombinant bacteria and the uses thereof for producing ethanol: The present invention relates to recombinant bacteria and the uses thereof, particularly for the production of ethanol. The invention also relates to methods for the production of such bacteria, as well as to nucleic acid constructs suitable for such production. The invention specifically relates to bacteria lacking a functional LDH... Agent:
20120058534 - Optimized biogas (biomethane) production process: The present invention relates to a process for pretreatment of a feedstock in a pretreatment tank. Various parameters, such as oxidation-reduction potential, pH, and temperature, are monitored in the pretreatment tank to determine whether the oxidation-reduction potential, pH, and temperature are each within a predetermined range. The volume of feedstock... Agent: Stover & Associates, Inc.
20120058535 - Biofuel production in prokaryotes and eukaryotes: Terpene synthases are enzymes that directly convert IPP & DMAPP to terpenes, such as fusicoccadiene. Described herein are methods and compositions for the production of terpenes and terpenoids for use as fuel molecules or other useful components. Genetically engineered enzymes capable of producing terpenes and terpenoids are also described.... Agent: Sapphire Energy, Inc.
20120058536 - Polymer made of a primary amine functionalized polymer and a hemicellulose: The present invention relates to a polymer made of a primary amine functionalized polymer and a hemicellulose e.g. chitosan and xyloglucan, wherein the primary amine functionalized polymer is covalently bound to the hemicellulose, and to a cross-linking agent composition comprising the polymer. A method wherein manufacturing a cellulose containing product... Agent: Swetree Technologies Ab
20120058537 - Chimeric truncated and mutant variant of tissue plasminogen activator (t-pa) resistant to plasminogen activator inhibitor-1: The various embodiments herein provide a chimeric truncated and mutant variant of a tissue plasminogen activator (t-pa) and a method for preparing the same. According to an embodiment herein, the mutant variant comprises a signal sequence domain, followed by a chimeric tetrapeptide, followed by a tripeptide, followed by a kringle... Agent: Pasteur Institute Of Iran (ipi), No. 69
20120058538 - Helper-free rescue of recombinant negative strand rna virus systems: The present invention relates methods of generating infectious negative-strand virus in host cells by an entirely vector-based system without the aid of a helper virus. In particular, the present invention relates methods of generating infectious recombinant negative-strand RNA viruses intracellularly in the absence of helper virus from expression vectors comprising... Agent:
20120058539 - Method for orthopoxvirus production and purification: The present invention relates to a method for producing and purifying a wild type, an attenuated and/or a recombinant Orthopoxvirus. The present invention relates to a purified wild type, attenuated and/or recombinant Orthopoxvirus obtained by the method of the invention and to a pharmaceutical composition, preferably a vaccine, comprising said... Agent: Transgene S.a.
20120058541 - Engineering resistance to aliphatic alcohols: The present disclosure provides improved systems for the biological production of certain aliphatic alcohol compounds. In particular, the present disclosure provides biological systems that show improved resistance to aliphatic alcohol toxicity; in sonic embodiments, such improved resistance allows for increased levels of aliphatic alcohol production. Accordingly, the present disclosure provides,... Agent: Butamax(tm) Advanced Biofuels LLC
20120058540 - Probiotic enriched and low organic acid food products: This invention relates to a fruit-based food product such as beverages or fruit purees, comprising a concentration of live and stable probiotics, which is preferably greater than 108 CFU/ml, a high fruit content, which is preferably greater than 50%, and a low organic acid content, and wherein the production of... Agent: Compagnie Gervais Danone
20120058542 - Systems and methods for regulating algal biomass: The invention relates to systems and methods for regulating algal biomass in offshore waters near an oil and gas production platform. The systems of the invention encompasses a plurality of modules for managing nutrients, algae, and aquaculture, including enclosures for containing aquatic organisms, and various operating subsystems that are operably... Agent: Live Fuels ,inc.
20120058543 - Purified plasmodium and vaccine compositions: Disclosed are substantially purified Plasmodium sporozoites and preparations of Plasmodium sporozoites substantially separated from attendant non-sporozoite material, where the preparations of Plasmodium sporozoites have increasing levels of purity. Vaccines and pharmaceutical compositions comprising purified Plasmodium sporozoites are likewise provided. Methods of purifying preparations of Plasmodium sporozoites are also provided.... Agent: Sanaria, Inc.
20120058544 - Biomass decomposition apparatus and method thereof, and sugar-solution production system using biomass material: To include a hydrothermal decomposition unit 17 that transports a fed biomass material 11 from one side (a lower side) to the other side (an upper side) by a screw 14 in an apparatus body 13, feeds pressurized hot water 15, which is treat water, from the other side (the... Agent: Mitsubishi Heavy Industries, Ltd.
20120058545 - Method of treating an off-gas stream and an apparatus therefor: The present invention provides a method of treating an off-gas stream (80) comprising NH3 and H2S to provide a sulphate stream (910), the method comprising the steps of: (i) providing a first off-gas stream (80) comprising NH3, H2S, CO2 and optionally one or more of HCN, COS and CS2; (ii)... Agent:
20120058546 - Multiple surface acoustic wave sensor system: Provided is a multiple SAW sensor system capable of sensing a plurality of target materials in the SAW sensor with a single detector by using a multiplexer. According to the multiple SAW sensor system, the target materials in SAW sensors may be sensed with a single detector, thereby avoiding unnecessary... Agent: Samsung Electronics Co., Ltd.
20120058548 - Detection of biotargets using bioreceptor functionalized nanoparticles: A system for determining a presence of biomolecule targets includes a vessel holding a sample solution suspected of containing the biomolecule targets and a plurality of probes including bioreceptor functionalized metal nanoparticles including a plurality of metal atoms. The biomolecule targets when present in the sample solution bind to the... Agent: University Of Central Florida Research Foundation, Inc.
20120058547 - Method and system for nucleic acid detection using electroconductive or electrochemically active labels: A method for electrochemically or electrically detecting nucleic acids, utilizes electrochemically active or electrically conductive reporter materials. An electric voltage is applied and electric signals are measured to the electrodes that are suitable for detecting or quantifying the nucleic acid(s) in a sample. This technique is suitable for point-of-use applications,... Agent: The Hong Kong University Of Science And Technology
20120058549 - Method and apparatus for analyzing vitamin e in lipoproteins: A method of analyzing vitamin E components in a lipoproteinby subjecting a lipoprotein-containing sample to ion exchange chromatography to separate the lipoprotein, reacting the separated lipoprotein to a pretreating solution containing an organic solvent and a surfactant to liberate vitamin E components, and then subjecting the liberated vitamin E components... Agent: Tosoh Corporation
20120058550 - Bioreactors comprising fungal strains: Disclosed herein are compositions comprising an isolated cellulose degrading fungus. Also disclosed are culture compositions and bioreactor compositions comprising the cellulose degrading fungus. Further described herein are filtration and extraction devices comprising the cellulose degrading fungus. Still further disclosed are bioprocessing facilities for and methods for producing co-products resulting from... Agent: Menon & Associates, Inc.
20120058551 - Technology and method to study microbial growth and adhesion to host-related surfaces and the host-microbiota interactions: The present invention relates to in vitro adhesion modules that allow growth, stabilization and study of microbial communities that adhere to and colonize host-related surfaces, that mimic transport of chemical compounds across epithelial surfaces and simulate host-microorganism interactions and adaptation. It includes the provision of micromolar amounts of oxygen via... Agent: Universiteit Gent
20120058552 - Sample processing units, systems, and related methods: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing... Agent: Ibis Biosciences, Inc.
20120058553 - Apparatus for transporting biological samples: A container assembly for storing, treating, transporting and stabilizing a biological sample includes a container, a cap and a sample holder removably received in the container. The sample holder can be a platform-like device dimensioned to be supported on a ledge formed in the side wall of the container. The... Agent: Becton, Dickinson And Company
20120058555 - Rnai expression constructs: The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.... Agent: Benitec, Inc.
20120058554 - Synthetic polysaccharide microcarriers for culturing cells: A cell culture polysaccharide microcarrier includes (1) a cross-linked polysaccharide microcarrier base having a neutral or negative charge at pH 7, and (ii) a polypeptide conjugated to the base. The polypeptide may contain a cell adhesive sequence, such as RGD. Cells cultured with such microcarriers exhibit peptide-specific binding to the... Agent:
20120058556 - High surface area substrate for cell culture: A cell culture microcarrier includes (1) a polystyrene microcarrier base having a remnant of a carboxylic acid group, and (ii) a polypeptide conjugated to the base via the remnant of the carboxylic acid group. The polypeptide may contain a cell adhesive sequence, such as RGD. Cells cultured with such microcarriers... Agent:
20120058557 - Mineralized three-dimensional bone constructs: The present disclosure provides ex-vivo derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture... Agent:
20120058558 - Composition for preserving platelets and method of using the same: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally,... Agent: Biovec Transfusion, LLC
20120058559 - Monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests... Agent: Baxter Healthcare S.a.
20120058560 - Bioreactor system: Bioreactors may be used for the cultivation of cells, in particular of adherent cells, and, in particular for the cultivation and propagation of cell cultures, and utilized in methods for the cultivation of cells. A particular area of application is the use of the bioreactors in the GMP-compliant, fully automatic... Agent:
20120058561 - Methods and compositions for stem cell cultures: The disclosure provides methods and compositions useful for culturing stem cell including embryonic stem cells, adult stem cells, and embryonic germ cells.... Agent: The Regents Of The University Of California
20120058562 - Reprogramming immortalized b cells: Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell... Agent:
20120058563 - Production of 2-keto-l-gulonic acid: The present invention relates to the production of recombinant microorganisms, in particular of the genus Gluconobacter, for production of 2-keto-L-gulonic acid (2-KGA) and/or L-ascorbic acid (hereinafter also referred to as Vitamin C), wherein the microorganism has been modified to overexpress L-sorbose dehydrogenase (SDH). This overexpression has been achieved by introducing... Agent:03/01/2012 > 106 patent applications in 58 patent subcategories. listing by industry category
20120052479 - Methods, compositions and devices for inducing stasis in tissues and organs: The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for preserving tissue for transplantation purposes... Agent:
20120052480 - Biofilters for living spaces: Techniques described herein are generally related to a biofilter for living spaces. The biofilter may include an organic biofilter medium to serve as a growth base for both plants and one or more microbial colonies. Example embodiments include systems, articles, methods and apparatus, as well as other embodiments that are... Agent: Empire Technology Development LLC
20120052481 - Assays for detecting modified compounds: Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by... Agent: Enzo Life Sciences, Inc., C/o Enzo Biochem, Inc.
20120052486 - Identification of high grade or >= cin2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (hpv) and hpv-associated cancers: A method and a kit for determining a disease stage of a papilloma virus infection in a human subject is disclosed. The method comprises: obtaining a sample from said human subject, said sample consisting of a tissue sample comprising proteins or a cell sample comprising proteins; contacting said sample with... Agent:
20120052482 - Kit for detecting hepatitis c virus and method of detecting hepatitis c virus using the same: A kit for detecting HCV in a test sample is disclosed. In addition a method is described for the real-time detection of HCV in a test sample using the kit. According to method of detection, the results of the detection can be rapidly identified with a reduced number of copies... Agent: Samsung Techwin Co., Ltd.
20120052483 - Kit for detecting hiv-1 and method for detecting hiv-1 using the same: A method is described for the real-time detection of HIV-1 gene target DNA in a sample, including obtaining HIV-1 specific cDNA by reverse transcription, amplifying a portion of the cDNA, and detecting the amplicons so produced using probe labeled with a detectable marker.... Agent: Samsung Techwin Co., Ltd.
20120052484 - Methods of diagnosing cervical cancer: The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus... Agent:
20120052485 - Sperm separation system: The present invention provides a naturally based Sperm Separation System (SSS) for separation of at least a portion of sperm cell populations (SCP) within an original semen sample, such that an enπched SCP sample is obtained, comprising a a sperm separation device, comprising ι) a first chamber adapted to contain... Agent: Lotus Bio (nymphaea) Ltd.
20120052491 - Cell analyzer and cell analyzation method: A cell analyzer includes: a measuring portion which measures cells that are nuclear stained; a displaying portion which displays a histogram of a fluorescence intensity by using a result of the measurement by the measuring portion; and a determining unit which obtains a number of strong-area cells that are distributed... Agent: Nihon Kohden Corporation
20120052489 - Methods and compositions for sequencing nucleic acids using charge: The invention provides methods and compositions, and systems for determining the identity of nucleic acids in nucleotide sequences, including sequences with one or more homopolymer regions. The methods of the invention include improvements so as to accurately identify sequences, including the difficult homopolymer sequences that are encountered during nucleotide sequencing,... Agent: Intelligent Bio-systems, Inc.
20120052490 - Methods and systems for monitoring reactions: Methods and systems for monitoring reactions by observing signals deriving from those reactions, using signal processing that allows differentiation between signals that are otherwise optically overlapping by conventional detection methods. Centroid determination is used to identify signal sources that are presenting confounding overlapping signals due to their physical proximity, and/or... Agent: Pacific Biosciences Of California, Inc.
20120052488 - Photodamage mitigation compounds and systems: Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold... Agent: Pacific Biosciences Of California, Inc.
20120052487 - Methods and compositions for selecting sirna of improved functionality: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.... Agent: Dharmacon, Inc.
20120052496 - Compositions, kits and methods for detection of campylobacter nucleic acid: The disclosed invention is related to compositions, kits and methods comprising one or more oligomers targeting 16S rRNA target nucleic acid from Campylobacter species jejuni, coli and/or lari. Compositions include amplification oligomers, detection probe oligomers and/or target capture oligomers. Kits and methods comprise at least one of these oligomers.... Agent: Gen-probe Incorporated
20120052498 - Detection of nucleic acids: Methods of detecting various types of nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Detection assays may be conducted at least in vitro, in cellulo, and in situ. Nucleic acids which are optionally captured on a solid support are detected,... Agent: Affymetrix, Inc.
20120052497 - Method of simultaneously amplifying target sequences from salmonella spp. and e. coli o157:h7 and kit therefor: Methods are described for the rapid, simultaneous and quantitative PCR detection of pathogenic Salmonella spp. and E. coli O157: H7 nucleic acid sequences in a sample in real-time. The detection method is fast, accurate and suitable for high throughput applications. Convenient, user-friendly and reliable diagnostic kits are also described for... Agent: Samsung Techwin Co., Ltd.
20120052499 - Methods for whole-cell analysis of gram-positive bacteria: This application pertains to methods for the whole-cell analysis of gram-positive bacteria. The methods are capable of making a determination of whether or not a sample (e.g. a clinical sample) comprises one or more select gram-positive bacteria as well as, for example, whether or not none, some or all of... Agent: Advandx, Inc.
20120052494 - Oligonucleotides for detecting e. coli o157:h7 strains and use thereof: Oligonucleotides, a kit, and a method for detecting E. coli O157:H7 strains are provided. According to the kit for detecting E. coli O157:H7 strains and the method of detecting E. coli O157:H7 strains by using the kit, the results of the detection can be rapidly identified with a reduced number... Agent:
20120052495 - Oligonucleotides for detecting listeria monocytogenes and use thereof: Oligonucleotides suitable for detecting Listeria monocytogenes, and a kit and a method of efficiently detecting Listeria monocytogenes in a sample by using the oligonucleotides are provided.... Agent: Samsung Techwin Co., Ltd.
20120052492 - Oligonucleotides for detecting listeria spp. and use thereof: An oligonucleotide specifically binding to 23S rRNA gene of Listeria spp., and a kit and a method of efficiently detecting Listeria spp. in a sample by using the oligonucleotide are provided.... Agent: Samsung Techwin Co., Ltd.
20120052493 - Oligonucleotides for detecting listeria spp. and use thereof: Oligonucleotides specifically binding to Listeria spp., and a kit and a method of efficiently detecting Listeria spp. in a sample by using the oligonucleotides are provided.... Agent: Samsung Techwin Co., Ltd.
20120052506 - Cyanine dyes: The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods... Agent: Pacific Biosciences Of California, Inc.
20120052508 - Genetic markers and diagnostic methods for resistance of breast cancer to hormonal therapies: This application provides a method to identify genetic markers associated with increased sensitivity or resistance to hormonal therapies using an outlier analysis. More specifically, this application discloses that amplifications on chromosomes 8 and 17 are associated with increased proliferation and poor outcome in ER-positive breast cancer, and amplicons 17q21.33-q25.1, 8p11.2... Agent: Rutgers, The State University Of New Jersey
20120052500 - Kit for detecting chlamydia trachomatis strains and method for detecting chlamydia trachomatis strains using the same: A kit for detecting Chlamydia trachomatis in a test sample is disclosed. In addition a method is described for the real-time detection of Chlamydia trachomatis in a test sample using the kit. According to method of detection, the results of the detection can be rapidly identified with a reduced number... Agent: Samsung Techwin Co., Ltd.
20120052501 - Kit for detecting htlv strains and use thereof: Methods and kits are described for the rapid and quantitative real-time PCR detection of HTLV nucleic acid sequences in biological samples. The procedure promises to facilitate the high throughput detection of HTLV in a cost effective and reliable manner.... Agent: Samsung Techwin Co., Ltd.
20120052503 - Kit for detecting neisseria gonorrhoeae strains and method for detecting neisseria gonorrhoeae strains using the same: A kit for detecting Neisseria gonorrhoeae in a test sample is disclosed. In addition a method is described for the real-time detection of Neisseria gonorrhoeae in a test sample using the kit. According to method of detection, the results of the detection can be rapidly identified with a reduced number... Agent: Samsung Techwin Co., Ltd.
20120052505 - Methods for detecting embryonic stem cells, induced pluripotent stem cells, or cells undergoing reprogramming to produce induced pluripotent stem cells: where the rosamine derivative compound selectively produces fluorescent signals for embryonic stem cells, induced pluripotent stem cells, and/or cells undergoing reprogramming to produce induced pluripotent stem cells. These methods also include the steps of contacting the sample with the rosamine derivative compound and detecting the presence of the embryonic stem... Agent: National University Of Singapore
20120052504 - Methods of screening for risk of proliferative disease and methods for the treatment of proliferative disease: A method of screening a subject for a proliferative disease risk factor comprises detecting the presence or absence of upregulation of the CLN3 gene in the subject. The upregulation of the CLN3 gene in the subject indicates the subject is at increased risk of developing a proliferative disease. Methods of... Agent: Duke University
20120052507 - Phospholinked dye analogs with an amino acid linker: In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA... Agent: Pacific Biosciences Of California, Inc.
20120052502 - Real-time pcr detection using stabilized probes: A probe protector oligonucleotide is described for the improved CATACLEAVE™ probe detection of nucleic acid sequences in a test sample. The probe protector oligonucleotide is designed to be substantially complementary to the FRET pair labeled CATACLEAVE™ oligonucleotide probe. Base pairing between the probe protector oligonucleotide and the CATACLEAVE™ oligonucleotide probe... Agent: Samsung Techwin Co., Ltd.
20120052509 - Method for measuring in vivo hematotoxicity with an emphasis on radiation exposure assessment: The present invention relates a method for assessing in vivo hematotoxicity. The method utilizes differential staining of nucleated and non-nucleated blood cells, and also differential labeling of cells with functional versus dysfunctional mitochondrial membrane potential. Quantitative analyses can be conducted on stained whole blood specimens, and is based on blood... Agent: Litron Laboratories, Ltd.
20120052510 - Method for discrimination of metaplasias from neoplastic or preneoplastic lesions: The present invention relates to a method for discrimination of p16INK4a overexpressing metaplasias from neoplastic or preneoplastic p16INK4a overexpressing lesions by determination of the level of high risk HPV encoded gene-products such as e.g. HPV E2 and/or HPV E7 molecules in biological samples in the course of cytological testing procedures.... Agent: Mtm Laboratories, Ag
20120052511 - Methods for controlling pore morphology in aerogels using electric fields and products thereof: In one embodiment, an aerogel or xerogel includes column structures of a material having minor pores therein and major pores devoid of the material positioned between the column structures, where longitudinal axes of the major pores are substantially parallel to one another. In another embodiment, a method includes heating a... Agent: Lawrence Livermore National Security, LLC
20120052513 - Gold sub-nanoclusters and uses thereof: The present technology relates gold sub-nanoclusters comprising a gold core and one or more thiolates bound to the gold core, wherein the gold core consists essentially of 23 gold atoms. Methods of preparing and using such sub-nanoclusters are also provided.... Agent:
20120052512 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble Advanced... Agent: Astute Medical, Inc.
20120052516 - Method for diagnosing a hemoglobin-related disorder: The invention relates to a method for diagnosing, staging and/or monitoring a hemoglobin-related disorder such as β-thalassemia or a treatment against said hemoglobin-related disorder in a subject in need thereof based on the detection and/or quantification the presence of free α-Hb pool in a biological sample obtained from said subject.... Agent:
20120052517 - Methods for testing an immune response using cultures of t cells, b cells and dendritic cells: The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics,... Agent: Sanofi Pasteur Vaxdesign Corporation
20120052514 - Potency test for vaccine formulations: The invention relates to certain methods for the determination of an antigen content of a first antigen in a mixture comprising two or more antigens. The invention also relates to a potency test for an antigen in a combination vaccine. The method allows the determination of the antigen content in... Agent:
20120052515 - Therapeutic applications of noncovalent dimerizing antibodies: Compositions and methods for providing antibodies having noncovalent, self-binding properties are disclosed. Such autophilic antibodies can bind cellular receptors to promote apoptosis of target cells and enhance therapeutic efficacies in the treatment of patients with debilitating or life-threatening diseases. Representative diseases targeted by the autophilic antibodies are lymphomas, breast cancers,... Agent: Innexus Biotechnology International Limited
20120052518 - Fluorescent probe for measuring protease: A compound represented by the formula (I) or a salt thereof (R1 represents hydrogen atom, or a substituent; R2 to R7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R8 and R9 represent hydrogen atom, or an alkyl group; X represents a C1-C3 alkylene group; and... Agent: The University Of Tokyo
20120052519 - Methods for assaying alpha-l-iduronidase enzymatic activity: Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I.... Agent: University Of Washington
20120052520 - Methods, compositions and a kit suitable for determining the concentration of gamma-hydroxy butyric acid (ghb) in a sample: Methods to determine the concentration of gamma-hydroxy butyric acid (GHB) in a sample as well as compositions and a kit suitable for carrying out said methods. Also, the use of the methods for application on a microtiter plate or an auto-analyzer.... Agent: Buhlmann Laboratories Ag
20120052522 - Apparatus and method for the study of metabolism: Embodiments of the present invention feature methods and apparatus in which fluids circulating between a plurality of vessels containing different cell types or tissues are monitored for metabolites following the introduction of a sample.... Agent: Waters Technologies Corporation
20120052524 - Cell evaluation system using cell sheet and method for using the system: Three-dimensional information on a biological parameter relating to at least one selected from viability, proliferating ability, migration, and differentiation of cultured cells can be obtained by a simple two-dimensional analytical technique by constructing a cell evaluation system including a multilayered cell sheet, target cells, and a two-dimensional analyzer.... Agent: Tokyo Womens Medical University
20120052523 - Devices and methods for observing the cell division: The present invention relates to methods and devices for observing the cell division, in particular the cytokinetic ring, methods for preparing such devices, methods for studying modifications of cell division, and methods for screening compounds of interest which enhance or inhibit cell division.... Agent: Centre National De La Recherche Scientifique
20120052525 - Polymers for growing cells: The present invention provides a polymer substrate for use in the attachment and functioning of hepatocyte and hepatocyte like cells. In particular, the polymer substrate is a polyurethane polymer.... Agent:
20120052521 - Sheath flow device and method: A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel,... Agent: The Government Of The United States Of America, As Represented By The Secretary Of The Navy
20120052526 - Tissue infiltration method: A tissue infiltration apparatus (1) for specimens present in cassettes (5) comprises at least two liquid containers (7, 11, 13, 15) and a transport apparatus (6). Multiple cassettes (5) are receivable in a transport basket (4). The transport apparatus (6) is configured in such a way that at least two... Agent: Leica Biosystems Nussloch Gmbh
20120052527 - Laboratory method and experimental specimen for validating the efficacy of antimicrobial agents on bovine carcasses: A laboratory method and a test specimen for efficiently and accurately assessing and validating the efficacy of an antimicrobial to treat pathogens on a beef carcass. The method and model employ one or more carcasses from calves that have not received colostrum.... Agent:
20120052528 - Method for producing selective medium and use thereof: An object to be solved by the present invention is to provide a method for producing a selective medium that allows a target microorganism to predominantly proliferate in the simultaneous presence of many different microorganisms according to specific criteria. The object is solved by a method for producing a selective... Agent: The University Of Tokyo
20120052530 - Combinatorial dna library for producing modified n-glycans in lower eukaryotes: The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The invention provides nucleic acid molecules and combinatorial libraries which... Agent: Glycofi, Inc.
20120052529 - Episomal expression vector for metazoan cells: The invention relates to a vector comprising an origin of replication for episomal maintenance in a metazoan cell, a gene for episomal maintenance in the metazoan cell, and a telomeric polynucleotide sequence. The vector can be used for episomal expression of RNA and polypeptides in metazoan cells.... Agent: University Of Medicine & Dentistry Of New Jersey
20120052531 - Polymerase chain reaction apparatus: A polymerase chain reaction (“PCR”) apparatus includes a PCR chip holder which accommodates and supports a PCR chip, a housing which supports ends of the PCR chip holder, a temperature control element which moves perpendicularly with respect to the PCR chip holder in a space between the housing and the... Agent: Samsung Electronics Co., Ltd.
20120052532 - Biosynthesis of cmp-legionaminic acid from fructose-6-p, and respective pathway intermediates, using novel gdp-linked precursors: The sialic acid-like sugar legionaminic acid is found as a virulence-associated surface glyco-conjugate in Legionella pneumophila and Campylobacter coli. In this work, we have purified and biochemically characterized eleven candidate biosynthetic enzymes from C. jejuni, thereby fully reconstituting the biosynthesis of legionaminic acid and its CMP-activated form, starting from fructose-6-P.... Agent:
20120052533 - 4s-iota-carrageenan sulfatase and use thereof to obtain alpha-carrageenan: The present invention relates to 4S-iota-carrageenan sulfatase and to the use thereof for partially or totally converting the iota-carrageenan into iota-/alpha-carrageenan or alpha-carrageenan. The invention also relates to the method for extracting said enzyme from a Pseudoalteromonas bacteria population or from red marine algae. Finally, the present invention relates to... Agent: Centre National De La Recherche Scientifique (cnrs )
20120052534 - Process for improving the hydrolysis of cellulose in high consistency systems: Provided is a process for the enzymatic hydrolysis of cellulose to produce glucose from a pretreated cellulosic feedstock. The process comprises providing an aqueous slurry of the pretreated cellulosic feedstock that has a water content that is less than about 140% of the maximum water holding capacity of the pretreated... Agent: Iogen Energy Corporation
20120052535 - Production of terpenes and terpenoids in glandular trichome-bearing plants: Methods for producing heterologous terpenes, terpenoids and/or small molecules in transgenic glandular trichome-bearing plants are provided, as well as the transgenic glandular trichome-bearing plants capable of producing the heterologous terpenes, terpenoids and small molecules. The genetically engineered glandular trichome-bearing plants contain and express one or more genes which encode proteins... Agent:
20120052539 - Process for making a triglyceride composition: A process for preparing a triglyceride composition comprising from 50 to 80% by weight StOSt and from 5 to 20% by weight StOO comprises reacting triolein with stearic acid in the presence of a 1,3-specific lipase from Rhizopus oryzae to form interesterified glycerides and fractionating the interesterified triglycerides.... Agent:
20120052536 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as energy, fuels, foods or materials. For example, methods are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce an intermediate or product, e.g., by fermentation.... Agent: Xyleco, Inc.
20120052537 - Recombinant microbial host cells for high eicosapentaenoic acid production: Engineered strains of the oleaginous yeast Yarrowia lipolytica are disclosed herein that are capable of producing microbial oil comprising greater than 25 weight percent of eicosapentaenoic acid [“EPA”], an omega-3 polyunsaturated fatty acid, measured as a weight percent of dry cell weight.... Agent: E. I. Du Pont De Nemours And Company
20120052538 - Triglycerides with high content of unsaturated fatty acids: The invention relates to a process for producing a triglyceride product comprising the steps of: (a) subjecting a triglyceride feedstock comprising at least 25 mole %, based on the total amount of acyl groups in the triglycerides, unsaturated C18 fatty acid residues to an alcoholy- sis reaction with an alcohol... Agent: Novozymes A/s
20120052540 - High performance metabolic bacteria: The present invention relates to novel stress-resistant bacteria and the uses thereof. More specifically, the invention relates to isolated stress-resistant bacteria having advantageous properties for the production of organic acids or alcohols in various culture conditions. The invention also relates to methods of producing organic acids or alcohols using said... Agent: Centre National De La Recherche Scientifique
20120052541 - Improved carbon capture in fermentation: The present invention relates to improvement in efficiency in gasification for use with syngas fermentation. In particular, the invention relates to increasing the overall carbon capture efficiency of a gasification/fermentation process to produce products such as alcohols.... Agent: Lanzatech New Zealand Limited
20120052542 - Reducing carbon dioxide production and increasing ethanol yield during microbial ethanol fermentation: The present invention provides compositions and methods for producing ethanol wherein the amount of CO2 by-product is reduced during the fermentation process. The invention includes the use of oxidized lignin during the fermentation process.... Agent: Athena Biotechnologies, Inc.
20120052543 - Method for pretreating biomass to produce bioethanol: Disclosed is a method for preparing bioethanol from biomass. The feedstock for preparation of bioethanol, i.e. the biomass, is pretreated by a combination of chemical and physical methods. The method is advantageous in that detoxification is unnecessary since the substances that inhibit fermentation are not produced and acid reconcentration for... Agent: Industry Academic Cooperation Foundation Keimyung University
20120052544 - Enucleation of cells with psoralens: The present invention provides compositions and methods for enucleation of cells. In particular, the present invention provides the use of psoralens in enucleation of feeder and/or eggs cells.... Agent:
20120052545 - lipolytic enzyme lip2: The present invention provides a novel nucleic acid sequence, designated LIP2, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for... Agent:
20120052546 - Bacteriophage lytic enzymes as alternative antimicrobials: The present invention relates to isolated Clostridium perfringens bacteriophage lytic enzymes from baccteriophages CP26F and CP39O, and uses in controlling Clostridium perfringens.... Agent: The United State Of America, As Represented By The Secretary Of Agriculture
20120052547 - Methods for control of flux in metabolic pathways through protease manipulation: The embodiments described herein pertain to cells, and methods for preparing cells, that can be used as biocatalysts by altering enzymes that compete for a substrate or product of a pathway of interest such that the targeted enzyme is sensitive to a site-specific protease, which protease is expressed but relocated... Agent:
20120052548 - Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells: The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.... Agent: Allergan, Inc.
20120052549 - Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids: Mutant delta-5 desaturases, having the ability to convert dihomo-gamma-linolenic acid [DGLA; 20:3 omega-6] to arachidonic acid [ARA; 20:4 omega-6] and/or eicosatetraenoic acid [ETA; 20:4 omega-3] to eicosapentaenoic acid [EPA; 20:5 omega-3] and possessing at least one mutation within the HPGG (SEQ ID NO:7) motif of the cytochome b5-like domain and... Agent: E. I. Du Pont De Nemours And Company
20120052550 - Temperature-responsive polymer particles in protein separation applications: The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins. The present invention also relates to crosslinked hydroxylic polymer particles functionalized with temperature-responsive copolymer, and to methods of preparing such particles.... Agent:
20120052551 - Polypeptides having alpha-amylase and granular starch hydrolyzing activity: The present invention relates to a polypeptide having alpha-amylase activity obtained from a strain of Aspergillus niger.... Agent: Danisco US Inc.
20120052552 - Method of separating components of technical eggs, edible eggs, yolk and whites and products therefrom: The present invention relates to methods for the separation of various components from eggs. More particularly, the present invention relates to methods for the separation of proteins and lipids from eggs, including technical eggs (inedible) or edible eggs, yolks or whites, which comprises cross-linking the lipids of eggs with a... Agent: Biova, L.L.C.
20120052553 - Multiply-substituted protease variants: Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in... Agent: Danisco US Inc.
20120052554 - Gene delivery system and method of use: A recombinant replication competent retrovirus for gene deliver and gene therapy is provided. The recombinant retrovirus has a heterologous nucleic acid sequence, a sequence encoding a cell- or tissue-specific ligand or a sequence for transcriptional targeting, or a combination of both a cell- or tissue-specific ligand and a cell- or... Agent: University Of Southern California
20120052555 - Enrichment of listeria spp.: A medium for enriching Listeria spp. without polymerase chain reaction (PCR) inhibition and a method of using the medium.... Agent: Samsung Techwin Co., Ltd.
20120052556 - Cell isolation apparatus: A cell isolation apparatus includes: a cylinder member that is inserted into a container into which a reagent is to be introduced; a net which is stretched over the cylinder member; a tissue acquiring unit that is projected from the cylinder member; and a bottom lid portion that is configured... Agent: Nihon Kohden Corporation
20120052558 - Flow controlled microfluidic devices: A microfluidic device (10) comprises at least one reactant passage (60) defined within a layer (50) of the microfluidic device (10) and comprising one or more chambers (70, 75) disposed along a central axis (110). Each chamber (100) is divided at a flow-splitting region (150) into two subpassages (140, 145)... Agent: Corning Incorporated
20120052557 - Microchip: The present invention provides a microchip which is made by bonding a first substrate having a groove provided at the substrate surface and a second substrate together, and has a fluid circuit therein, the fluid circuit having a separation portion for separating a first component, and a groove which constitutes... Agent: Rohm Co., Ltd.
20120052559 - Cell isolation apparatus: A cell isolation apparatus includes: a chamber body which includes a chamber into which tissue is to be introduced; an isolation member which is moved in the chamber and which is to collide with the tissue to isolate a cell; and a controlling portion which controls an operation of the... Agent: Nihon Kohden Corporation
20120052560 - System and method for serial processing of multiple nucleic acid assays: The present invention relates generally to systems and methods for the rapid serial processing of multiple nucleic acid assays. More particularly, the present invention provides for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a... Agent: Canon U.s. Life Sciences, Inc.
20120052561 - Systems and methods for analyzing bodily fluids: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.... Agent:
20120052563 - Optical system for high resolution thermal melt detection: This invention relates to systems and methods for imaging sample materials within a microfluidic device during an assay reaction process. In accordance with certain aspects of the invention, images are formed with a pixel array and a region of interest (“ROI”) is defined within the pixel array. Image values, such... Agent: Canon U.s. Life Sciences, Inc.
20120052562 - Test module with microfluidic device having laminar structure and sample receptacle: A test module having an outer casing for hand held portability, and, a microfluidic device for processing a biological sample mounted in the outer casing, the microfluidic device having a lab-on-a-chip (LOC) device with a cap, the LOC device having a supporting substrate and a microsystems technologies (MST) layer on... Agent: Geneasys Pty Ltd
20120052564 - Non-contact radiant heating and temperature sensing device for a chemical reaction chamber: An apparatus and methods are provided for heating and sensing the temperature of a chemical reaction chamber without direct physical contact between a heating device and the reaction chamber, or between a temperature sensor and the reaction chamber. A plurality of chemical reaction chambers can simultaneously or sequentially be heated... Agent: Life Technologies Corporation
20120052565 - Porous and non-porous cell culture substrate: A cell culture article has substrate that is predominantly opaque and that provides a three-dimensional (e.g., irregular) surface, but incorporates an optically transparent, substantially regular (e.g., two-dimensional) surface to serve as a microscopic observation and imaging window for the 3D cell culture. In many embodiments, the 3D portion of the... Agent:
20120052566 - Anti-vegf-c antibodies and methods using same: The invention provides VEGF-C antagonists, such as anti-VEGF-C antibodies, and their use in the prevention and treatment of tumor progression.... Agent:
20120052567 - Microstructure for particle and cell separation, identification, sorting, and manipulation: The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element (16) interposed between an inlet region (20) and... Agent: Parsortix, Inc.
20120052568 - Non-static suspension culture of cell aggregates: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.... Agent: Regents Of The University Of Minnesoto
20120052569 - Tag peptide having a protease recognition sequence and use thereof: Provided is a tag peptide in which a protease recognition sequence and an epitope of an antibody against the tag peptide are overlapped and thereby the protease recognition sequence per se is usable for detection or purification. Also provided is a purification method for recombinant proteins using the tag peptide... Agent: Osaka University
20120052570 - Method for temporally controlling the biological activity of proteins in vertebrates, and applications thereof: The present invention relates to a method for tightly temporally controlling the biological activity of a protein of interest in a vertebrate, upon induction of the activity of a fusion protein comprising said protein of interest and an ERM polypeptide containing a mutated ligand binding domain of the human oestrogen... Agent: The Board Of Trustees Of The University Of Illinois
20120052571 - Differentiation of human embryonic stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 80% of the cells in the population express markers characteristic of the definitive endoderm lineage.... Agent: Janssen Biotech, Inc.
20120052572 - Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for... Agent:
20120052574 - Novel reagents for transfection of eukaryotic cells: Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as... Agent: Molecular Transfer, Inc.
20120052573 - One-pot synthesis of linear-like polyethylenimine for intracellular imaging and nucleic acid delivery: A method of synthesizing polyethyleneimine with a substantially linear backbone is disclosed. The method comprises exposing ethylenediamine dissolved in a solution to electromagnetic radiation for a sufficient time to polymerize the ethylenediamine and thereby resulting in formation of polyethylenimine with a substantially linear backbone in the solution. A method of... Agent: National Health Research Institutes
20120052577 - Culture system for stem cell propagation and neural and oligodendrocyte specification: The present invention provides methods and compositions for culturing stem cells, such as neural stem cells, and includes inducing the specification of neural stem cells to the oligodendrocyte phenotype and specification of multipotent cells ie. iPS cells and ES cells.... Agent: The Regents Of The University Of California
20120052575 - Differentiation of human embryonic stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 85% of the cells in the population express markers characteristic of the definitive endoderm lineage.... Agent: Janssen Biotech, Inc.
20120052576 - Differentiation of pluripotent stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method utilizing an agent that degrades retinoic acid to produce a population of pancreatic endocrine precursor cells.... Agent: Janssen Biotech, Inc.
20120052578 - Gassing system: A gas-introduction system useful, for example, in biotechnology for supplying cells or microorganisms with oxygen. The gas-introduction system has a bubble column and a distributor. In the vessel there is situated a liquid medium which is to be supplied with gas. A vector is used as transport medium for the... Agent: Bayer Technology Services Gmbh
20120052581 - Microporous cell culture substrates: Surfaces of thermoplastic articles are rendered microporous by contacting the surface with a composition that includes a solvent. The article has a birefringence of 0.0001 or greater and the composition has a solvent strength configured to swell but not dissolve the polymer.... Agent:
20120052579 - Peptide-modified microcarriers for cell culture: A cell culture article including a microcarrier having a peptide-modified polymer surface of the formula (I) where AAj represents at least one covalently bonded peptide, j is an integer of from 5 to 50, m, n, o, Sur, X, R, R′, and the mer ratio (m-o:n:o), including salts thereof, are... Agent:
20120052580 - Peptide-modified surfaces for cell culture: A cell culture article including a pre-blocked, peptide-modified, polymer surface of the formula (I), where AAj represents at least one covalently bonded peptide, j is an integer of from 5 to 50, m, n, o, Sur, X, R, R′, and the mer ratio (m-o:n:o), including salts thereof, are as defined... Agent:
20120052582 - Nucleic acids, compositions and methods for the excision of target nucleic acids: Nucleic acids, compositions, and methods that allow for the excision of one or more loci from the genome of a host cell are provided herein. In particular, provided herein is an excisable nucleic acid construct comprising, in a 5′ to 3′ orientation: a first tandem repeat nucleic acid, a first... Agent: Amyris, Inc.
20120052583 - Novel nuclear reprogramming substance: Reprogramming substances capable of substituting for Klf4, selected from the group consisting of members of the IRX family (e.g., IRX6), members of the GLIS family (e.g., GLIS1), members of the PTX family (e.g., PITX2), DMRTB1, and nucleic acids that encode the same, are provided. Also provided are a method of... Agent: Japan Biological Informatics Consortium
20120052584 - Regulating the production of isoprenoids in algal cells: The invention relates to a method for increasing the production level of isoprenoids in an algal cell. The method includes increasing expression of a polynucleotide sequence that encodes 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (IDS) in the algal cell. In another aspect, the invention relates to a method for increasing the production level... Agent: The City University Of New York Represented By The Research Foundation Of The City University Of NyPrevious industry: Education and demonstration
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