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Chemistry: molecular biology and microbiology February patent applications/inventions, industry category 02/12

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
02/23/2012 > 90 patent applications in 49 patent subcategories. patent applications/inventions, industry category

20120045752 - Fiber sampler for recovery of bioaerosols and particles: A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers formed into a fiber mat and configured to collect bioparticles thereon, and includes a viability enhancing material provider disposed in a vicinity of the plurality of fibers and... Agent: Reseach Triangle Institute

20120045751 - Generic sample preparation: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids... Agent: Roche Molecular Systems, Inc.

20120045747 - Kit for detecting hepatitis b virus and method for detecting hepatitis b virus using the same: A kit for detecting HBV in a test sample is disclosed. In addition a method is described for the real-time detection of HBV in a test sample using the kit. According to method of detection, the results of the detection can be rapidly identified with a reduced number of copies... Agent: Samsung Techwin Co., Ltd.

20120045750 - Kit for detecting hiv-2 and method for detecting hiv-2 using the same: A kit for detecting HIV-2 strains in a test sample is disclosed. In addition a method is described for the real-time detection of HIV-2 strains in a test sample using the kit. According to method of detection, the results of the detection can be rapidly identified with a reduced number... Agent: Samsung Techwin Co., Ltd.

20120045749 - Methods of categorizing an organism: The invention generally relates to methods of identifying and categorizing organisms and more specifically methods of generating and using patterns of chromosomal variation in order to classify organisms.... Agent: Opgen, Inc.

20120045754 - Novel gold nanostructures and methods of use: The invention is drawn to novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors, conduits for fluids, and electronic conductors. The nanostructures can be used in microfluidic devices, for transporting fluids between devices and structures in analytical devices, for conducting electrical currents between devices and structure in... Agent:

20120045748 - Particulate labels: A methodology for bioassays and diagnostics in which a particulate label (ranging in size from nm-scale molecular assemblages to organisms on the scale of tens or hundreds of microns), such as, but not limited to, nanoparticles, bacteria, bacteriophage, Daphnia, and magnetic particles, serve carriers for analytes bound by molecular recognition... Agent:

20120045753 - Sequences diagnostic for shrimp pathogens: Primers have been isolated that are diagnostic for the detection of the white spot syndrome virus (WSSV). The primers are based on a new portion of the WSSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods.... Agent: E. I. Du Pont De Nemours And Company

20120045763 - Antibodies against cells of fetal origin: This invention relates to antibodies that specific bind to fetal CD36+ cells in preference to binding to maternal CD36+ cells and methods for using these antibodies to detect and separate fetal cells from adult biological fluids including maternal peripheral blood.... Agent: The Board Of Trustees Of The University Of Illinois

20120045757 - Apparatus and methods for analysing fluorescent particles: According to an embodiment of the invention, an apparatus to detect fluorescence from a sample is disclosed. The apparatus comprises a sample plane onto which the sample is arranged, an excitation light unit including at least a light source to illuminate the sample, and a detection unit comprising at least... Agent:

20120045755 - Her-2 binding antagonists: There is disclosed a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO. 1 or SEQ ID NO:12, wherein the polypeptide... Agent: Oregon Health & Science University

20120045758 - Imprinting in very small embryonic-like (vsel) stem cells: Methods for determining a degree of pluripotency in a first putative stem cell relative to a second putative stem cell are provided. In some embodiments the methods include comparing the imprinting status in the first versus the second putative stem cell of a locus selected from among Igf2-H19, Rasgrf1, lgf2R,... Agent:

20120045762 - Lmna gene and its involvement in hutchinson-gilford progeria syndrome (hgps) and arteriosclerosis: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal... Agent: The Gov Of The Usa As Represented By The Secretary Of The Dept Of Health And Human Services

20120045764 - Method of expanding human hepatocytes in vivo: Described herein is a method of expanding human hepatocytes in vivo using an immunodeficient mouse which is further deficient in fumarylacetoacetate hydrolase (Fah). The method comprises transplanting human hepatocytes into the immunodeficient and Fah-deficient mice, administering an IL-1R antagonist to the mouse and allowing the hepatocytes to expand. Alternatively, the... Agent:

20120045756 - Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids: Methods and materials for determining the presence of at least one nucleic acid in a sample are provided, said methods comprising (1) a purification step using sequence specific hybrid capture; (2) an amplification step; and (3) a detection step comprising contacting the target nucleic acid with a plurality of detectably... Agent: Qiagen Gaithersburg, Inc.

20120045759 - Methods for detecting nucleic acid hybridization: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.... Agent: Anaspec Incorporation

20120045761 - Probes and primers for detection of chikungunya: The present disclosure gives a detailed description of methods for determining the presence of Chikungunya viral nucleic acids in blood/serum/plasma samples by employing “Oligonucleotide” probes. The designed “Oligonucleotide” probes can be used for qualitative or quantitative detection of Chikungunya virus in an infected sample by employing Real time PCR.... Agent: Bigtec Private Limited

20120045760 - Single nucleotide polymorphism within an intronic p53 binding motif of the prkag2 gene: The present invention relates to single nucleotide polymorphism (SNP). In particular, it relates to a SNP within an intronic p53 binding motif of the PRKAG2. Nucleic acid molecules and methods for aiding assessment of a patient's risk of developing cancer by determining the patient's genotype for a p53 binding motif... Agent: Karolinska Institutet

20120045769 - Cellular assay employing detectable protein: Provided herein are assays useful, for example, for determining the activity of a protein involved in a cellular process. In some embodiments, the activity of the protein is assessed using a nucleic acid tag, and in particular, by detecting the presence of a nucleic acid tag. Such assays can be... Agent: Discoverx Corporation

20120045765 - Composite liquid cells: A sample handling method may include drawing an encapsulating liquid from an encapsulating-liquid input; discharging the drawn encapsulating liquid (a) onto a free surface of a carrier liquid in a carrier-liquid conduit comprising a stabilisation feature and (b) proximate to the stabilisation feature, the encapsulating liquid being immiscible with the... Agent: Gencell Biosystems Ltd.

20120045766 - Jarid1b for target gene of cancer therapy and diagnosis: The present invention relates to the roles played by the JARID1B genes in cancers and features a method for treating cancers by administering a composition comprising a double-stranded molecule against the JARID1B genes or a vector encoding them. The present invention also features methods for diagnosing cancers by detecting the... Agent: Oncotherapy Science, Inc.

20120045770 - Lung tissue model: The present invention provides for an engineered three dimensional (3D) pulmonary model tissue culture which is free of any artificial scaffold.... Agent:

20120045767 - Magnetic beads having surface glycoconjugates and use thereof: Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.... Agent: Life Technologies Corporation

20120045768 - Methods and compositions to detect and differentiate small rnas in rna maturation pathway: Methods to specifically detect and differentiate one or more small RNAs in miRNA maturation pathway.... Agent:

20120045771 - Method for analysis of nucleic acid populations: The invention relates to a method for isolation of target molecules from a nucleic acid population.... Agent: Febit Holding Gmbh

20120045772 - Affinity hydrogel and label independent detection methods thereof: e

20120045773 - Cell adhesion inhibitor and applications thereof: According to one aspect of the present invention, there is provided a cell adhesion inhibitor for a cancer cell, containing an antibody to a protein containing the same or substantially the same amino acid sequence as the amino acid sequence, represented by SEQ ID No: 2 or represented by SEQ... Agent: University Of Miyazaki

20120045777 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the... Agent: Millennium Pharmaceuticals, Inc.

20120045774 - Lipoprotein associated phospholipase a2, inhibitors thereof and use of the same in diagnosis and therapy: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.... Agent: Smithkline Beecham Corporation

20120045775 - Phosphospecific pak antibodies and diagnostic kits: The present invention relates to the use of phosphorylated p21-activated protein kinases (PAK), especially PAK4, as biomarkers of tumorogenesis. The present invention contemplates the use of phosphospecific antibodies for detecting phosphorylated PAK from mammalian biopsies, as well as screening assays for identifying compounds that modulate PAK activity. Also contemplated is... Agent: Sugen, Inc.

20120045776 - Monoclonal antibody ds6, tumor-associated antigen ca6, and methods of use thereof: The present application describes a monoclonal antibody selected from the group consisting of monoclonal antibody DS6, monoclonal antibodies that specifically bind to the antigen or epitope bound by monoclonal antibody DS6, and fragments of the foregoing that specifically bind to the antigen or epitope bound by monoclonal antibody DS6. Methods... Agent:

20120045778 - Elisa for haptoglobin-matrix metalloproteinase 9 complex as a diagnostic test for conditions including acute inflammation: A method for detecting a haptoglobin-matrix metalloproteinase 9 (Hp-MMP9) complex in a biological sample. The sample includes incubating the biological sample with a capture reagent immobilized on a solid support to bind Hp-MMP9 to the capture reagent. The capture reagent includes a monoclonal antibody that binds MMP9. The method detects... Agent: The Ohio State University Research Foundation

20120045779 - Method for diagnosing endometriosis and diagnostic kit for endometriosis: It is an object of the present invention to provide: a method for determining endometriosis, in which a blood sample from a subject can be used, and which is capable of determining endometriosis with higher sensitivity and higher precision than those of a conventional method using only a conventional endometriosis... Agent: Mochida Pharmaceutical Co., Ltd.

20120045781 - Pathology biomarker assay: Methods of diagnosis or of quantitation of pathological conditions comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a biofluid sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of pathology. The immunoassay is conducted... Agent: Nordic Bioscience A/s

20120045780 - Signal biomarkers: Diagnostics relating to C-type natriuretic and erythropoietin signal peptides and fragments, and kits, uses and applications therefor.... Agent:

20120045782 - Imatinib immunoassay: Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids.... Agent:

20120045783 - Method of determining tropomyosin in chitosan: A method capable of easily determining with high accuracy a protein in chitosan, the protein having a potential relevance to the development of an allergy, specifically tropomyosin and the content of the peptide. According to the method, tropomyosin is determined by immunoassay with the chitosan being in a state dissolved... Agent: Dainichiseika Color & Chemicals Mfg. Co., Ltd.

20120045784 - Biotinidase assay: The present technology discloses biotinidase assay, biotinidase substrates (I) and a kit wherein the biotinidase substrate includes a label molecule separated from the biotin carbamoyl group by a linker X longer than about 4 Å but shorter than about 27 Å.... Agent: Joachim Ngiamas Trustee For Joachim Ngiam Trust Fund Abn

20120045785 - Hybrid prokaryotic-eukaryotic tubulins and use thereof: The present invention embraces hybrid Prosthecobacter-eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin.... Agent:

20120045788 - Device for sample preparation: A pipette tip or tube containing chromatographic media contained and held in place in said tube by using low melting point porous polymer particles. Such pipette tips or tubes can be used for sample preparation, filtration and synthesis of small molecules and biomolecules.... Agent:

20120045787 - Flexible micro-carrier system: Micro-carrier systems may be used to carry and identify sample materials through an analysis system. Analysis systems may include an image sensor integrated circuit containing image sensor pixels. A channel containing a fluid with particles such as cells may be formed on top of the image sensor. Micro-carriers may be... Agent:

20120045791 - Method and a blood oxygen tester for detecting the arterial or venous blood: A method and a blood oxygen tester for determining whether a blood sample is arterial or venous blood are disclosed. A blood oxygen tester for determining whether a blood sample is arterial or venous blood includes a housing and a blood sample receptacle defined by the housing. A blood oxygen... Agent:

20120045789 - Method for screening of antiviral agents: A method for screening for an antiviral agent capable of blocking a viral viroporin by determining whether a test agent can rescue expression of a fragment of a viral viroporin in a Single Protein Production system of Escherichia coli is provided.... Agent: University Of Medicine And Dentistry Of New Jersey

20120045790 - Microdissection method and information processing system: In a first aspect, a method for use in biology, histology, and pathology, comprises: providing a digital first image (44) of a first slice (12) of an object (10) comprising biological material; generating a digital second image (46) of a second slice (14) of the object; determining a region of... Agent: Koninklijke Philips Electronics N.v.

20120045786 - Opto-fluidic microscope diagnostic system: An image sensor integrated circuit may contain image sensor pixels. Channels containing a fluid with cells or other material may be formed on top of the image sensor. The image sensor pixels may form imagers. Each imager may be located in a respective one of the channels. Reactant chambers may... Agent:

20120045792 - Dried blood spotting paper device and method: A dried blood-spotting device includes a carrier card having a window therethrough along with a punchable glass fiber paper disposed in the window for a uniform absorption of a blood droplet sample into a homogeneous circular sport. The glass fiber paper is configured for enabling improved analysis for small molecules... Agent:

20120045793 - Expression constructs comprising fungal promoters: The present invention provides promoters derived from a filamentous fungus. These promoters have application in the fields of molecular biology, microbiology, fungal genetics and production of biofuels and other products.... Agent: Codexis, Inc.

20120045794 - Preparation of protective antigen: e

20120045795 - Method for producing a cell capable of high-yield production of heteroproteins: The present invention relates to a method for producing a cell capable of high-yield production of a desired polypeptide, wherein a strongly bicarbonate transporter-expressing cell into which DNA encoding the desired polypeptide has been introduced is cultured in the presence of a high concentration of methotrexate and a cell capable... Agent:

20120045798 - Method and device for electrowetting genetic analysis: It relates to a method for amplifying at least one nucleotide molecule contained in a sample (E) comprising the following successive steps consisting of (a) subjecting said sample (E) to a 1st amplification step on an area (Z1) of a support; (b) bringing by electrowetting at least one portion of... Agent: Commissariat A L Energie Atomique Et Aux Energies Alternatives

20120045797 - Nucleic acid amplification procedure: The invention provides methods for amplification of polynucleotide sequences using primers containing single-Cstranded RNA. The methods employ use of an enzyme capable of cleaving single-stranded RNA, such as RNase I, to degrade a first RNA-containing primer prior to addition of a second RNA-containing primer. The invention also provides compositions and... Agent: Nugen Technologies, Inc.

20120045796 - Nucleic acid hotstart technology: The present invention relates to molecules used as hotstarts for polymerases, including among others the DNA polymerase and reverse transcriptase.... Agent:

20120045799 - Thermocycler seal composition, method, and application: An immiscible mixture of wax and silicone oil is provided for application to the inner surface of a thermocycle reactor tube. The mixture is a solid at typical room temperatures and under typical product storage conditions, but at temperatures above the melting point of the mixture (e.g., >46° C. and... Agent: Rheonix, Inc.

20120045800 - Microalgae biofuel production system: A system for processing oil from algae is disclosed. Specifically, the system recycles byproducts of the process for use as nutrients during algae growth and oil production. The system includes a conduit for growing algae and an algae separator that removes the algae from the conduit. Also, the system includes... Agent:

20120045802 - Liquid fractionation method for producing biofuels: A method for producing biofuels is provided. A method of making biofuels includes dewatering substantially intact algal cells to make an algal biomass, sequentially adding solvent sets to the algal biomass, and sequentially separating solid biomass fractions from liquid fractions to arrive at a liquid fraction comprising neutral lipids. The... Agent: Heliae Development, LLC.

20120045801 - Recombinant ralstonia eutropha capable of producing polylactic acid or polylatic acid compolymer, and method for producing polylactic acid or polylatic acid copolymer using same: Provided are a recombinant Ralstonia eutropha capable of producing polylactate or a hydroxyalkanoate-lactate copolymer, and a method of preparing polylactate or a hydroxyalkanoate-lactate copolymer using the same. The recombinant Ralstonia eutropha, which is prepared by introducing a gene of an enzyme converting lactate into lactyl-CoA and a gene of a... Agent:

20120045803 - Method for production of substance in candida utilis using xylose as carbon source: Disclosed is a yeast strain of Candida utilis, wherein the yeast strain has been transformed with at least one of three genes that are operatively linked to a promoter sequence and encode polypeptides having activities of xylose reductase, xylitol dehydrogenase, and xylulose kinase. The yeast strain is useful for producing... Agent: Kirin Holdings Kabushiki Kaisha

20120045804 - Conversion of hexuronic acid to hexaric acid: The present invention relates to a method and microbial host strain for converting a hexuronic acid to a hexaric acid. In particular, the invention relates to the con-version of D-galacturonic acid to meso-galactaric acid (mucic acid). The invention also concerns an isolated nucleotide sequence. According to the present method a... Agent: Teknologian Tutkimuskeskus Vtt

20120045805 - System and method for the synthesis of thermoplastic biopolymer: The various embodiments herein provide a system and a method of synthesis of thermoplastic biopolymer such as poly-β-hydroxy butyric acid wherein the activated sludge and synthetic waste water are acclimatized in a sequential batch reactor. The diazotrophs are reacted with CO2 in a secondary carbon source reactor. The acclimated activated... Agent:

20120045806 - Enzymatic synthesis of nootkatone: Polypeptide with an amino acid sequence according to SEQ ID No. 1 or a variant in which up to 10% of the amino acids have been altered by insertions, deletions or substitution.... Agent: N-zyme Biotec Gmbh

20120045807 - Process for producing chemicals using microbial fermentation of substrates comprising carbon monoxide: A process for converting a substrate such as carbon monoxide to useful chemicals has been developed. The process involves providing a substrate comprising CO to a bioreactor which contains a culture of one or more micro-organisms and anaerobically fermenting the substrate to produce 2,3-butanediol (BDO). The BDO is next converted... Agent: Lanzatech New Zealand Limited

20120045808 - Production method for 1,3-propanediol using recombinant microbial strain having glycerol oxidation metabolic pathway blocked: Provided is a method of producing 1,3-propanediol by culturing a recombinant strain in which the glycerol oxidative pathway had been blocked, and more particularly a method of producing 1,3-propanediol by two-step culture of a recombinant strain in which the oxidative pathway that produces byproducts in the glycerol metabolic pathway had... Agent: Korea Research Institute Of Biosctechnology

20120045809 - Engineered microorganisms for the production of one or more target compounds: The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms comprise isobutanol producing metabolic pathway with one or more isobutanol pathway enzymes localized in the mitochondria. In various embodiments... Agent: Gevo, Inc.

20120045810 - Method for production of bio-ethanol using watermelon seeds: Provided is a method for production of bioethanol using watermelon seeds and, more particularly, a method for producing bioethanol with high production yield using watermelon seeds, including: sterilizing watermelon seeds, which are usually discarded as food waste from domestic houses, supermarkets, farm houses, etc., at 121° C. for 10 to... Agent:

20120045811 - Egvii endoglucanase and nucleic acids encoding the same: The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same.... Agent: Danisco US Inc.

20120045812 - Production of isoprene under neutral ph conditions: Embodiments of the present disclosure relate to a process for producing isoprene from a starch substrate by saccharification and/or fermentation. The saccharification is effectively catalyzed by a glucoamylase at a pH in the range of 5.0 to 8.0. At a pH of 6.0 or above, the glucoamylase possesses at least... Agent: Danisco US Inc.

20120045813 - Gene encoding a protein having an ability to enhance a selenate reduction activity: According to the present invention, a protein having an ability to enhance a selenate reduction activity, a gene encoding it, and a method for selenate reduction using them are provided... Agent:

20120045814 - Method of producing synthetic petroleum from coal or hydrocarbons or from c,h or oxygen using a host microorganism: The invention relates to a method of making microorganisms capable of producing petroleum from coal, or wood or certain other fossil fuels or raw materials, wherein gene sequences responsible for such production are isolated from microorganisms capable of such production, and transfected into suitable hosts, with better productivity or viability.... Agent:

20120045815 - Crystal structure of glutaminyl cyclase: A novel crystal structures of human and murine glutaminyl cyclase (QC, EC, methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase.... Agent: Probiodrug Ag

20120045816 - Novel glycosylated polypeptides: Provided herein are glycosylated polypeptide compositions with substantially reduced Neu5Gc content. The glycosylated polypeptides compositions with substantially reduced Neu5Gc content can be obtained from cell sources cultured with Neu5Gc competitor or from non-human animal sources fed a diet supplemented with Neu5Gc competitor. Also provided herein are methods of treating a... Agent: Sialix, Inc.

20120045817 - Compositions and methods comprising alpha-amylase variants with altered properties: Described are compositions and methods relating to variant alpha-amylases having altered biochemical properties and advantageous performance characteristics as compared to a reference alpha-amylase. The variants are suitable for use in various industrial applications such as starch conversion, ethanol production, laundry, dishwashing, pulp and paper production, textile desizing, and/or sweetener production.... Agent:

20120045818 - Plant-based production of heterologous proteins: Described herein are viral amplicon-based protein expression systems and methods useful for producing heterologous proteins, such as enzymes, by agroinfiltration. The methods involve producing an Agrobacterium with a Ti plasmid encoding a heterologous protein, infecting plant cells with the Agrobacterium, allowing expression of the heterologous protein, and recovering the heterologous... Agent: The Regents Of The University Of California

20120045819 - Binding molecules for human factor viii and factor viii-like proteins: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of... Agent: Dyax Corp.

20120045820 - New antibiotic-sensitive lactic acid bacteria strains: Many probiotic Bifidobacteriacea contains an active tetW that renders the cells resistant to tetracycline. This may present a risk of a horizontal transfer of functional antibiotic genes. The present invention relates to a method of obtaining novel tetracycline-sensitive strains of the genus of Bifidobacteriacea (Bifidobacterium sp.). In particular, the present... Agent: Chr. Hansen A/s

20120045821 - Methods and compositions for genetic engineering of cyanobacteria to produce ethanol: Provided herein are compositions and methods for genetic engineering of cyanobacteria to produce ethanol. In one aspect, the present invention provides a polynucleotide construct comprising a copper ion inductive promoter and a sequence encoding a pyruvate decarboxylase (pdc) enzyme. In another aspect, the present invention provides a genetically engineered cyanobacterium... Agent:

20120045822 - Cleaning system comprising an alpha-amylase and a protease: Described are compositions and methods involving a Bacillus alpha-amylase and a protease. The compositions and methods are especially effective for cold water cleaning applications.... Agent: Danisco US Inc.

20120045823 - Method and apparatus for collecting biological materials: A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is... Agent: Biomet Biologics, LLC

20120045824 - Device for early diagnostics of cancer: Method of cancer treatment with direct contact between proteins secreted by cancer tumor and patient's blood T-lymphocytes including the stage of weakening during some time humoral system of immunity by medical preparation, in particular by immunodepressant against this system, without weakening cellular system of immunity.... Agent:

20120045825 - Diagnostic test tape for liquid samples: A diagnostic test tape for liquid samples is provided comprising a flexible transport tape and a plurality of test fields applied to the transport tape that are distributed in the longitudinal direction of the tape, where said test fields comprise a detection layer and a spreading net spanning the detection... Agent:

20120045826 - Kits and devices for detecting analytes: The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific... Agent:

20120045828 - Apparatus for magnetic separation of cells: Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20120045827 - Separation of antigen-specific memory b cells with a conjugated biopolymer surface: The present invention provides materials and methods for the isolation of immune cells. In one embodiment, the present invention provides a device for the isolation and separation of antigen-specific memory B cells. Immune cells will be separated by flowing the cells along a ligand-conjugated biopolymer surface. The ligand may be... Agent: Biofactura, Inc.

20120045829 - Identification of antigenic peptides from multiple myeloma cells: Multiple myeloma (MM) is a clonal B cell malignancy and remains essentially incurable by conventional anti-tumor therapy. Patients with MM have a median survival of only three years. MM is characterized by proliferation and accumulation of mature plasma cells in the bone marrow (BM) leading to bone destruction, BM failure,... Agent:

20120045830 - Stem cell aggregate suspension compositions and methods of differentiation thereof: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.... Agent: Viacyte, Inc.

20120045832 - Multipotent neural stem cells: An isolated multipotent neural stem cells has a phenotype identified by expression of the protein β-tubulin IV and Olig2 and the absence of the proteins NG2, PLP, and GFAP.... Agent:

20120045831 - Poly(lactic-glycolic)acid cross linked alendronate (plga-aln) a short term controlled release system for stem cell differentiation and drug delivery: The present invention relates to a bisphosphonates and synthetic polymeric carriers to form a sustained release system. The present invention also provides a method for preparing a sustained release system, comprising activation of the synthetic polymeric carriers and the cross linking reaction. The present invention further provides methods for enhancing... Agent: Kaohsiung Medical University

20120045833 - Bioreactor, control system and control method thereof: A bioreactor includes a cylinder, a mandrel and a filter film. The cylinder includes two end walls and a circumferential wall interconnected with the both end walls; the two end walls and circumferential wall define together a reaction chamber. The mandrel is disposed between the two end walls. The mandrel... Agent:

20120045834 - Method and apparatus for maintaining microcarrier beads in suspension: The invention relates to an impeller for growing adherent mammalian cells on microcarrier beads. In other aspects, the invention relates to methods of using the impeller and to bioreactors or cell separators comprising the impeller.... Agent: Ge Healthcare Uk Limited

20120045836 - Enzyme-based fed-batch technique in liquid cultures: The present invention is generally in the field of continuous and high-cell-density cultivation in laboratory- or large-scale liquid shaken cultures. More particularly it relates to a method of enzyme-based fed-batch (EnBase) for liquid microbial prokaryotic or eukaryotic cell cultivation having the possibility to manipulate the growth rate of the cultured... Agent: Biosilta Oy

20120045835 - Portable device based on immobilized cells for the detection of analytes: The present invention relates to a portable device for the detection of analytes, in particular toxic substances, comprising at least a whole-cell biosensor with cells immobilized onto a transparent and inert matrix that allows the maintenance of cell vitality. The matrix comprises a mixture of collagen and/or its enzyme degradation... Agent:

02/16/2012 > 138 patent applications in 78 patent subcategories. patent applications/inventions, industry category

20120040330 - Biological and chemical collection and detection: A fluorescence-cued Raman identification system comprises a collection subsystem to collect samples, a reagent treatment subsystem to treat collected samples and a fluorescence imaging subsystem that automatically takes at least one image of the collected sample. The subsystems further include a Raman spectroscopy subsystem that measures the spectrum of viable... Agent: Battelle Memorial Institute

20120040328 - Fermenter feed system for fermentable biomass of a biogas system and method for operating the feed system: A fermenter feed system for fermentable biomass of a biogas system comprising at least one fermenter, and a delivery and treatment device located between a biomass depot and the fermenter. A mechanical cell breakdown apparatus (6) processes the biomass for delivery (5, 10, 11, 14, 34) to the fermenter (18,19)... Agent:

20120040331 - Noninvasive bioreactor monitoring: A pair or receptacles capable of housing an emitter probe and a detector probe are installed inside a bioreactor to monitor the properties of the nutrient media without contacting the nutrient media.... Agent: Therapeutic Proteins, Inc.

20120040329 - Process for continuous production of bacteriophage: As bacteriophage use in industrial application grows there is a need for commercial quantities of identified bacteriophage. This invention discloses a continuous flow bacteriophage proliferation process that can provide commercial quantities of desired bacteriophage in concentrations suitable for industrial use. Host bacteria and virulent bacteriophage are fed into a reactor... Agent: Phage Biocontrol Research, LLC

20120040332 - Assay for detection of adrenal tumour: The invention relates to methods, assays and kits for detecting or monitoring adrenal tumours by detecting one or more adrenal steroid metabolites. The metabolites are selected from THS (tetrahydro-11-desoxycortisol), 5-PT (5-pregnenetriol), 5-PD (pregnenediol), PD (pregnanediol), PT (pregnanetriol), Et (etiolanolone), TH-DOC (tetrahydro-11-corticosterone), (5α-THA) 5α-tetra-11-hydrocorticosterone, and 5α-THF (5α-tetra hydrocortisol. An (Androsterone) may... Agent:

20120040333 - Methods to distinguish different disaccharide products after digestion with heparinases: Methods are provided for determining stereochemistry for a component of a composition where the composition includes a glycosaminoglycan (GAG) where the method includes (a) cleaving the GAG with a lyase; (b) separating the products of the cleaved GAG by chromatography in the presence of one or more solvents wherein at... Agent: New England Biolabs, Inc.

20120040337 - Conformational epitope initiated signal amplification: This invention relates to a method to generate a signal used to detect the presence or quantity of a biomarker in a sample. The signal generating reaction is initiated when the biomarker under assay interacts with a specific binding partner. The interaction produces a structural change in the binding partner... Agent:

20120040334 - Diagnostic transcript and splice patterns of hpv16 in different cervical lesions: The present invention relates to a method for differentiating in a subject with HPV16 between (i) a severe form of HPV16 infection and (ii) a mild form of HPV16 infection based on determining the amount of a first gene product and a second gene product in a sample of a... Agent: Deutsches Krebsforschungszentrum

20120040335 - Identification of porcine reproductive and respiratory syndrome virus: An enzyme-linked immunosorbent assay (ELISA) is based on the non-structural protein 7 (nsp7) of porcine reproductive and respiratory syndrome virus (PRRSV) and provides for the simultaneous detection and differentiation of serum antibodies directed against Type 1 (European) and Type 2 (North American) PRRSV. The invention provides a serological assay for... Agent: South Dakota State University

20120040336 - Lateral flow assays for non-diagnostic analytes: Methods of determining whether a non-diagnostic analyte is present in a non-diagnostic sample are provided. Aspects of the methods include applying a non-diagnostic sample to a sample receiving region of a lateral flow assay device and reading a detection region to determine whether a non-diagnostic analyte is present in the... Agent:

20120040339 - Imaging glyphosate in plant tissue: Methods and compositions are provided for spatial imaging and quantifying glyphosate in plant tissue. Glyphosate oxidoreductase is coupled to a cycling flavin mononucleotide-oxidoreductase-luciferase system. The resulting bioluminescence is proportional to the amount of glyphosate, allowing glyphosate to be observed within plant tissue and quantified.... Agent: Monsanto Technology LLC

20120040340 - Nucleotide analogs: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.... Agent: Helicos Biosciences Corporation

20120040338 - Rbm3 in testicular cancer diagnostics and prognostics: The present disclosure provides a method for determining whether a mammalian subject belongs to a first or a second group, wherein subjects of the first group have a higher risk of having a testicular disorder than subjects of the second group, comprising the steps of: evaluating an amount of RBM3... Agent: Atlas Antibodies Ab

20120040345 - 2-nitrobenzyl-modified ribonucleotides: This disclosure provides novel reversibly terminated ribonucleotides which can be used as a reagent for DNA sequencing reactions. Methods of sequencing nucleic acids using the disclosed nucleotides are also provided.... Agent: Alere San Diego, Inc.

20120040343 - Detecting and sorting methylated dna using a synthetic nanopore: Provided are methods for detecting, characterizing or separating DNA based on methylation. Heterogeneous DNA populations are separated based on DNA methylation by providing a membrane having a nanopore through which an electric field is applied. DNA of interest is introduced, and for a given threshold voltage across the nanopore, only... Agent:

20120040342 - Genetic indicators of weight loss: Methods for determining resistance to weight loss and susceptibility to binge eating episodes are described. The methods include determination of the presence of a obesity related alleles for a patient at single nucleotide polymorphism sites associated with the genes INSIG2, FTO, MC4R, and PCSK1. The total number of obesity alleles... Agent: Geisinger Clinic

20120040350 - Genetic markers of schizophrenia: The invention includes method of determining if a subject has a genetic predisposition to clinically diagnosed schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD).... Agent:

20120040351 - Genetic markers of schizophrenia: The invention includes method of determining if a subject has a genetic predisposition to clinically diagnosed schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD).... Agent:

20120040349 - Method for detecting nucleic acids: Method for detecting nucleic acids which employs a double-stranded oligonucleotide probe containing i) a first probe including a first label moiety, and ii) a second probe partially complementary with the first probe and including a second label moiety capable of interacting with the first moiety when brought in close proximity... Agent:

20120040341 - Method for the detection and diagnosis of cancer involving primers and probes for the specific detection of the mage-a3-marker: The present invention relates to MAGE-3 specific primers and probes for use new diagnostic kits and methods. The invention further relates to immunotherapeutic treatment of specific populations of cancer patients, suffering from MAGE-3 expressing tumours.... Agent:

20120040346 - Method of determining chemotherapy of metastatic tumor by assaying dpd gene expression in primary tumors: The invention relates to a method for determining a chemotherapeutic regimen for an individual, comprising obtaining a mRNA sample from a primary tumor specimen; determining a gene expression level for a tumor gene determinant in the specimen; comparing the gene expression level for the tumor gene determinant with a predetermined... Agent:

20120040348 - Methods for nucleic acid quantification: The invention relates to a method for quantification of amplified nucleic acids comprising the steps of: calculation of a measure of randomness M of the cycle-to-cycle amplification efficiency Ê(C) for target and comparative nucleic acids, —identification of the cycle numbers CM where M is minimal for target and comparative nucleic... Agent: Koninklijke Philips Electronics N.v.

20120040347 - Polymorphism in cyp3a4 gene affecting drug metabolizing and uses thereof: A method for predicting a subject's risk factors for CYP3A4-related disorders includes detecting the allelic status of a SNP in a nucleic acid sample of the subject.... Agent: The Ohio State University Research Foundation

20120040344 - Predictive use of cpg methylation: Determination of the methylation status of individual selected Cp/G dinucleotides/CpG groups 5′ to the coding region of selected genes, preferably in a perinatal tissue sample such as umbilical cord, can be used to predict future development of diverse phenotypic characteristics, such as indices of body composition indicative of for example,... Agent:

20120040358 - Biomarker panel for diagnosis and prediction of graft rejection: Methods are provided for monitoring a subject having a graft for an acute rejection (AR) response, e.g., to predict, to diagnose, and/or to characterize an AR response. In practicing the subject methods, the expression level of at least one gene in a sample from the subject, e.g., a blood or... Agent:

20120040364 - Compensator for multiple surface imaging: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be... Agent: Illumina, Inc.

20120040357 - Compositions, methods and kits to detect dicer gene mutations: In one aspect, the disclosure provides isolated nucleic acids, primers, and probes for the detection of mutations in a nucleic acid sequence for a DICER1 polypeptide.... Agent: Children's Hospital And Clinics Of Minnesota

20120040360 - Compositions, methods and kits to detect dicer gene mutations: In one aspect, the disclosure provides isolated nucleic acids, polypeptides, primers, and probes for the detection of mutations in a nucleic acid sequence for a DICER1 polypeptide.... Agent: Children's Hospital And Clinics Of Minnesota

20120040353 - Detection and quantification of micrornas in the circulation and the use of circulating micrornas as biomarkers in cancer: The present invention relates to the identification of biomarkers suitable for use in the diagnosis and prognosis of a number of cancers. In addition, the invention relates to improved methods for the identification and quantification of such biomarkers in samples taken from patients.... Agent: National University Of Ireland, Gaway

20120040359 - Endonuclease-enhanced helicase-dependent amplification: The invention provides methods and compositions for enhancing the speed and sensitivity of helicase-dependent amplification through the use of an endonuclease.... Agent:

20120040363 - Method for enriching a prokaryotic dna: A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of specifically binding to non-methylated CpG motifs, and separating the protein/polypeptide-DNA complex. Moreover, the application relates to a kit for... Agent: Sirs-lab Gmbh

20120040361 - Methods and compositions for detection of lethal system and uses thereof: Provided herein is a method for detecting the presence of lethal system in a patient using the expression of nuclear factor A (NFA) in marker cell. In another aspect, provided herein is a method for predicting if a patient has metastatic potential and is at risk of developing metastasis and... Agent: National Tsing Hua University

20120040356 - Methods for detecting oncofetal fibronectin: Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided herein, the sample is treated with a reagent and/or contacted with a non-specific binder. Provided are methods for testing subjects to ascertain health... Agent:

20120040354 - Methods of classifying the severity of diseases or disorders: The present invention relates to methods of classifying the severity of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 is compared to one or more reference levels of YKL-40, and the severity of said non-specific disease or disorder is deduced from said comparison. The... Agent:

20120040362 - Multipotent lymphohematopoietic progenitor cells: This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to... Agent:

20120040352 - Primers, probes and methods for nucleic acid amplification: Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non-symmetric PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled mismatch-tolerant probes permits analysis of complex targets.... Agent: Brandeis University

20120040355 - Ykl-40 as a marker for selection of treatment and monitoring of a disease: The present invention relates to a methods for selecting a treatment for a specific disease or disorder, together with a method of monitoring therapeutic treatment of a specific disease or disorder and a method of determining a prognosis for a subject before, during and after administering a treatment by determining... Agent:

20120040365 - New competence stimulating peptide: The present invention concerns a new competence stimulating peptide identified in Firmicutes, in particular Streptococcus, and more preferably S. thermophilus and methods of producing transformation competent Firmicutes, in particular Streptococcus, and more preferably S. thermophilus bacteria.... Agent:

20120040366 - Compositions, methods and uses for disease diagnosis: Embodiments of the present invention generally related to methods and compositions for diagnosing or predicting a genetic disorder. In certain embodiments, the methods may include use of rapid and inexpensive assay systems. Other embodiments concern novel mutation specific peptides associated with BRCA1 or BRCA2. In yet other embodiments, haploid cells... Agent: Tissue Genetics, Inc.

20120040367 - Construct system and uses therefor: The present invention discloses construct systems and methods for comparing different iso-accepting codons according to their preference for translating RNA transcripts into proteins in cell or tissues of interest or for producing a selected phenotype in an organism of interest or part thereof. The codon preference comparisons thus obtained are... Agent: The University Of Queensland

20120040368 - Mutated voltage-gated sodium channel nav alpha subunit for identification of modulators: Reagents, methods and kits for screening for compounds that modulate the activity of voltage-gated sodium channels (NaV), such as human NaV1.5/SC-N5A/hH1 are described. The reagents, methods and kits are based on mutated NaV alpha subunit polyptides of SEQ ID NO:5 with mutations at positions 372, 898, 1419 and 1711 (the... Agent: Universite Laval

20120040369 - On-board control detection: Embodiments disclosed herein relate to a sensor comprising an on-board control system and a testing system. The on-board system can determine viability of the control system or the testing system. Also disclosed are methods of using such a sensor.... Agent: Universal Biosensors Pty Ltd

20120040370 - Systems and methods for rapidly changing the solution environment around sensors: The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention also provides a system and methods for modulating, controlling, preparing, and studying receptors.... Agent: Cellectricon Ab

20120040373 - Integrated diagnosis of heparin-induced thrombocytopenia: Disclosed are methods for the early detection of heparin-induced thrombocytopenia comprising the quantitative detection of chemokine platelet factor-heparin complexes, autoantibodies to such complexes, and platelet activation. Also disclosed are assays to detect the propensity of a subject to develop heparin-induced thrombocytopenia.... Agent:

20120040374 - Method for detecting renal disease comprising measuring human megalin in urine: This invention provides a diagnostic kit and a diagnostic marker used for diagnosing a renal disease. This invention also provides a method for detecting a renal disease comprising measuring at least one type of human megalin existing in urine selected from among full-length human megalin and human megalin fragments of... Agent: Juntendo Educational Foundation

20120040375 - Anti-muc1 antibody: An object of the present invention is to provide an antibody which does not bind to a normal cell, and is specific for a cancer cell. The object was solved by the finding by the present inventors that an antibody obtained by immunizing an animal using a 2,3ST glycopeptide as... Agent: Shionogi & Co., Ltd.

20120040371 - Diagnosis of preeclampsia: The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained from pregnant women and the effects of such levels on the risk of developing complications of pregnancy, including hypertensive disorders such as... Agent: Yale University

20120040372 - Receptor tyrosine kinase assays: Methods for detecting phosphorylation of receptor tyrosine kinases (“RTKs”) upon activation and the modulation of activation by a candidate compound are provided. The method employs cells comprising two fusion products: (1) an RTK fused to a small fragment of β-galactosidase and (2) a phosphotyrosine binding peptide fused to the large... Agent: Discoverx Corporation

20120040376 - Lung cancer diagnostic polypeptide, method for detecting lung cancer, and method for evaluating therapeutic effect: A novel biomarker for use in lung cancer diagnosis is provided.... Agent: Riken

20120040378 - Meprobromate immunoassay: Carisoprodol is a centrally-acting prescription drug of known abuse. Upon ingestion it is rapidly metabolised to meprobamate, also a prescription drug with abuse potential. Current immunoassays are specific for carisoprodol and therefore have a short window of detection and, furthermore, are ineffective at detecting meprobamate. The current invention, underpinned by... Agent: Randox Laboratories Limited

20120040379 - Methods for differentiating plasma- derived protein from recombinant protein in a sample: The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation, when the plasma protein and the recombinant protein are essentially the same protein.... Agent: Baxter International Inc.

20120040377 - Recognition of cyp2e1 epitopes: A critical epitope of human cytochrome P4502E1 (CYP2E1) associated with the development of hepatic autoimmune disease, including methods and kits for diagnosis and prognosis using the critical epitope as a biomarker for hepatic autoimmune disease.... Agent: The Johns Hopkins University

20120040380 - Optically-detectable enzyme substrates and their method of use: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods... Agent: Life Technologies Corporation

20120040381 - Predicting mortality and detecting severe disease: Measurement of circulating ST2 and/or IL-33 concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, and the detection of severe disease.... Agent:

20120040382 - Method of detecting progression of a neurodementing disease: Isolated, monoclonal, human, anti-β-amyloid antibodies are provided which bind to dimeric forms of Ab with higher affinity than to monomeric forms of Ab and when bound to an Aβ polypeptide comprising Aβ(21-37) shield Aβ(21-37) from proteolytic digestion. The antibodies were shown to inhibit fibril formation and reduce plaque size in... Agent: Philipps-universitaet Marburg

20120040383 - Methods and kits relating to metabolite biomarkers for colorectal cancer: Embodiments of the present invention provide methods of assessing metabolite biomarkers to diagnose, monitor, prognose and treat colorectal cancer, as well as kits and systems in use thereof. In some embodiments, the metabolite biomarker profile of an subject suspected of having colorectal cancer may be compared to the metabolite biomarker... Agent:

20120040385 - Coagulogen raw material, process for producing the same, and method and apparatus for measuring physiologically active substance of biological origin using the same: Disclosed is a technique for obtaining a coagulogen raw material which can irreversibly inactivate the activity of a coagulase while retaining the function of coagulogen in an LAL reagent, a LAL reagent contaminated by an organism-derived biologically active substance or the like, and which can be used in a reagent.... Agent:

20120040384 - Lyophilised dabigatran: The invention relates to a lyophilised form of dabigatran of formula (I) its use as a calibrator in the assays for the determination of pharmacodinamic effects of dabigatran etexilate as well as such assays per se. In the preparation of the lyophilised standards, dabigatran is dissolved in an aqueous acidic... Agent: Boehringer Ingelheim International Gmbh

20120040386 - Fine-grained filler substances for photometric reaction films: There is proposed a diagnostic test element for detecting an analyte in a sample of a body fluid, more particularly in whole blood. The diagnostic test element comprises at least one test field having at least one detection reagent, wherein the detection reagent is set up to pass through at... Agent:

20120040387 - Method and reagent for measuring mevalonic acid, 3-hydroxymethylglutaryl coenzyme a, and coenzyme a: The present invention provides a method for measuring the concentration of an analyte in a test solution wherein the analyte is mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A, comprising the following steps (p) and (q): (p) a step of allowing an enzyme that catalyzes a reaction represented by Reaction Formula 1... Agent: Asahi Kasei Pharma Corporation

20120040388 - Cellulase-containing dish detergents: The present invention provides cellulase-containing dishwashing detergent compositions. The present invention also provides methods for the production of and use of such detergents. In addition, a spaghetti mix soil suitable for testing dishwashing detergents is also provided.... Agent:

20120040389 - Method for demonstration of a molecular event in a cell by means of fluorescent marker proteins: The invention relates to a method for demonstration of the occurrence of a molecular event, particularly in a cell, characterised by the detection of the ‘solubilisation’ of a fixed protein marker (or the fixing of a solubilised protein marker) which is a direct or indirect marker for the occurrence of... Agent: Institut National De La Sante Et De La Recherche Medicale (inserm)

20120040393 - Directed differentiation of primate pluripotent stem cells into functional basal forebrain cholinergic neurons (bfcns) and medium spiny gabaergic projection neurons: Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are disclosed.... Agent:

20120040392 - Dosimetry using sigma singlet oxygen spectroscopy: A method includes measuring a photoluminescence of sigma singlet state oxygen decaying to triplet state oxygen. A dosage of delta singlet state oxygen is determined based on the photoluminescence.... Agent: Empire Technology Development LLC

20120040390 - Method for introducing protein and/or peptide into cell: The method of intracellular introduction is a method for introducing a protein and/or peptide into a cell, which comprises the process of introducing a conjugate generated by binding of a compound adsorbable on a cell surface to a protein and/or peptide via a polysulfide bond into a cell and treating... Agent: Nippon Shokubai Com, Ltd.

20120040391 - Sepsis diagnostic test: The invention relates to a method for the extracorporeal qualitative or semi-quantitative determination of the amount of indicators for the systemic inflammatory response system (SIRS) or sepsis in the blood, blood serum, blood plasma, other body fluids or lavages or their constituents of human or animal subjects. In order to... Agent: Gambro Lunida Ab

20120040394 - Microtumours: A method of producing an in vitro microtumour comprising: seeding a colorectal neoplastic cell into a three dimensional scaffold comprising polysaccharide co-polymer; providing said cell with a culture medium that supports the growth thereof; and incubating said cell in said scaffold for a time sufficient for microtumors to form, wherein... Agent:

20120040395 - Enzyme catalyst immobilized on porous fluoropolymer support: Enzyme catalyst immobilized on porous flouropolymer supports. Catalytically active enzymes can be bound to a variety of fluoropolymer supports for use as a reaction catalyst. Moreover, consistently high rate of conversion during catalyst re-use over time is achieved. Furthermore, inactive enzyme catalyst can be stripped from the support and fresh... Agent: Eastman Chemical Company

20120040396 - Methods for purifying bio-organic compounds: Methods and systems for purifying bio-organic compounds are described. In certain embodiments, the methods comprise the steps of (a) providing a composition or an emulsion comprising a surfactant, host cells, an aqueous medium and a bio-organic compound produced by the host cells, wherein the solubility of the surfactant in the... Agent: Amyris, Inc.

20120040398 - Engineered cleavage half-domains: Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.... Agent: Sangamo Biosciences, Inc.

20120040397 - Photo-crosslinked nucleic acid hydrogels: Methods and compositions are provided for producing hydrogel nucleic acid structures using photo-crosslinking. Methods of using the photo-crosslinked hydrogels for cell-free protein production, and for encapsulating and delivering compounds, are also provided.... Agent:

20120040399 - Method for the production of recombinant polyomaviral vector particles: The present invention relates to improved methods for the production of viral particles, viral vector particles and recombinant proteins. In particular, the invention relates to improved methods for the production of recombinant polyomaviral vector particles and polyomaviral vector production cell lines. More in particular, the invention relates to methods for... Agent: Amarna Holding B.v.

20120040400 - Novel permanent human cell line: The present invention relates to a permanent human cell line comprising a nucleic acid sequence for the adenoviral gene functions E1A and E1B and the nucleic acid sequence for the SV40 large T-antigen or the Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1). Further, the present invention relates to a method... Agent: Cevec Pharmaceuticals Gmbh

20120040401 - Method for producing proteins: The invention relates to a transcriptionally active recombinant linear polynucleotide encoding a multimeric protein comprising in the following order, a first promoter sequence, a first encoding polynucleotide sequence, a bidirectional regulatory sequence, a second encoding polynucleotide sequence and a second promoter sequence, wherein the first and second encoding polynucleotide sequences... Agent: Ucb Pharma S.a.

20120040402 - Plasmid system for multigene expression: The present invention provides a plasmid system which facilitates the construction of a single amplifiable plasmid that, having the potential to accommodate many independent expression cassettes, has the ability to express multi-subunit complex proteins such as antibodies and receptors.... Agent: Schering Corporation

20120040403 - Diguanylate cyclase method of producing the same and its use in the manufacture of cyclic-di-gmp and analogues thereof: Described is a new stand-alone diguanylate cyclase polypeptide having a GGDEF motif and a mutated I-site that does not bind c-di-GMP. We demonstrate that the production yield of c-di-GMP and analogues was significantly increased by mutation of a conserved residue in the putative regulatory I-site.... Agent: Nanyang Technological University

20120040404 - Thermal cycling device: Multi-layer devices suitable for thermal cycling processes. The devices are particularly suitable for performing polymerase chain reactions (PCR). One embodiment includes a first conducting layer, a second conducting layer adjacent to the first layer, and a third conducting layer adjacent to the second layer opposite the first layer. Insulating layers... Agent:

20120040405 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent:

20120040406 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent:

20120040407 - Cellobiose 2-epimerase, its preparation and uses: The present invention has objects to provide a thermostable cellobiose 2-epimerase, its preparation and uses. The present invention attains the above objects by providing a thermostable cellobiose 2-epimerase, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a process for producing the enzyme, and a process... Agent: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

20120040412 - Amylases, nucleic acids encoding them and methods for making and using them: In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as amylases to catalyze the hydrolysis of starch into sugars.... Agent: Verenium Corporation

20120040409 - Heterologous biomass degrading enzyme expression in thermoanaerobacterium saccharolyticum: Thermophilic gram-positive anaerobic host cells, for example Thermoanaerobacterium saccharolyticum (“T sacch”), express heterologous biomass degrading enzymes, such as cellulases, and are able to produce useful fermentation products from cellulose. Useful fermentation products include, for example, ethanol, acetic acid, lactic acid or CO2. In order to provide maximum expression and activity... Agent: Mascoma Corporation

20120040411 - Process for the hydrolysis of cellulose: There is disclosed a process for the hydrolysis of cellulose comprising the sequential steps (a) mixing cellulose with a viscosity below 900 ml/g with an aqueous solution to obtain a liquid, wherein particles comprising cellulose in said liquid have a diameter of maximum 200 nm, wherein the temperature of the... Agent: Heli Inovatio Handelsbolag

20120040408 - Processing cellulosic biomass: Improved systems and methods for reducing costs and increasing yields of cellulosic ethanol are disclosed herein, along with plants genetically transformed for increased biomass, expression of lignocellulolytic enzyme polypeptides, and/or simplification of harvesting and downstream processing. Methods for processing biomass from these transgenic plants that involve less severe and/or less... Agent:

20120040410 - Thermohemicellulases for lignocellulosic degradation: Hemicellulase (xylanase) enzymes possessing endo-xylanase, laminarase, mannanase, arabinase and arabinofuranosidase activity are useful to degrade hemicellulose and other substrates to their constituent sugars.... Agent: The Board Of Regents For Oklahoma State University

20120040413 - Chlorine dioxide treatment of biomass feedstock: The instant invention pertains to the use of chlorine dioxide in new processes for treating lignocellulosic feedstocks, as well as, new compositions suitable for, for example, bioalcohol production. Advantageously, the processes and compositions of the present invention may be used in more environmentally friendly, cost-efficient production of fuels and, if... Agent: Georgia Tech Research Corporation

20120040414 - Expression of steady state metabolic pathways: The present disclosure pertains to a method for increasing the production of a desired product having: identifying a steady state metabolic pathway for the synthesis of a desired product from a desired substrate; producing a polynucleotide encoding one or more polypeptide that participates in the steady state metabolic pathway for... Agent:

20120040415 - Method for producing an l-amino acid: A method is provided for producing an L-amino acid which includes the steps of culturing a bacterium, which belongs to the family Enterobacteriaceae and is able to produce an L-amino acid, in a medium containing glycerol as a carbon source to produce and accumulate an L-amino acid in the medium,... Agent:

20120040416 - Novel aldolase and production process of substituted alpha-keto acids: 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.... Agent: Ajinomoto Co., Inc.

20120040417 - Hydroxynitrile lyase: An improved hydroxynitrile lyase characterized by having a mutation of substitution of at least one amino acid residue in the amino acid sequence of a wild-type hydroxynitrile lyase with another amino acid and by its hydroxynitrile lyase activity per transformant being higher than the hydroxynitrile lyase activity per transformant into... Agent: Mitsubishi Rayon Co., Ltd.

20120040418 - Method for producing 3-mercaptopropionic acid or salt thereof: The present invention provides is a method for producing 3-mercaptopropionic acid from 3-mercaptopropionamide or a salt thereof with the use of an amidase. The method enables the production of 3-mercaptopropionic acid on an industrial scale through an enzymatic reaction.... Agent: Mitsui Chemicals Inc.

20120040420 - Flavor compound-producing yeast strains: Disclosed are a novel flavor compound-producing yeast strain and methods of using the strain to produce flavor compounds.... Agent: Academia Sinica

20120040419 - Method for producing oil by cystofilobasidium spp.: An oil generation system is provided. The oil generation system includes a saccharide; and a working microorganism reacting with the saccharide to produce an oil, wherein the working microorganism has a genus being a Cystofilobasidium.... Agent: Fu-jen Catholic University

20120040421 - Acid production by fermentation: The invention provides methods for producing Lactate by anaerobic Fermentation. According to particular methods of the invention, Lactate is produced by anaerobic fermentation of a substrate comprising hydrogen and carbon monoxide.... Agent: Lanza Tech New Zealand Limited

20120040422 - Dicarboxylic acid production process: The present invention relates to a process for the production of a dicarboxylic acid and ethanol which comprises fermenting a genetically modified yeast in a suitable fermentation medium under anaerobic conditions at a pH value of between 1 and 5 and producing the dicarboxylic acid and ethanol. The invention also... Agent: DsmIPAsset B.v.

20120040423 - Fermentation: The present invention provides a method for providing a target chemical, comprising: providing a cellulose-derived slurry comprising fermentable saccharides in one or several containers; subjecting cellulose-derived slurry from said one or several containers to separation to provide a liquid fraction comprising part of said fermentable saccharides from said cellulose-derived slurry... Agent:

20120040424 - Process for the enantioselective enzymatic reduction of secodione derivatives: The invention relates to a process for the enantioselective enzymatic reduction of secodione derivatives. The secodione derivative is reduced with an oxidoreductase/dehydrogenase in the presence of NADH or NADPH as a cofactor. The secodione derivative is used in the reaction batch at a concentration of ≧10 g/l and the oxidized... Agent: Iep Gmbh

20120040425 - Process for the stereoselective enzymatic reduction of keto compounds: e

20120040426 - Primary alcohol producing organisms: The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.... Agent: Genomatica, Inc.

20120040427 - Process for the production of ethanol and butanol: The present invention relates to a process for the production of ethanol and butanol from biomass, and in particular to a process for the production of ethanol and butanol using two separate fermentation steps, said process comprising: a) passing a biomass feedstock to a first fermentation step, b) in said... Agent:

20120040428 - Procedure for extracting of lipids from algae without cell sacrifice: A system and method are disclosed for extracting lipids from algal cells. In the method, lipids are extracted from algal cells by exposing the algal cells in an aqueous medium to an electric field sufficient to cause release of lipids from said cells. In the system, an electric field is... Agent:

20120040429 - Devices, systems and methods for reducing the concentration of a chemical entity in fluids: A method of improving the blood compatibility of a blood-contacting surface includes immobilizing carbonic anhydrase on the surface, wherein the surface exhibits carbonic anhydrase activity of at least 20% of maximum theoretical activity of the surface based on monolayer surface coverage of carbonic anhydrase.... Agent:

20120040430 - Compositions useful for detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes: The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides... Agent: Enzo Life Sciences, Inc. C/o Enzo Biochem, Inc.

20120040432 - Methods and materials for delivering molecules: This document relates to methods and materials involved in delivering molecules to a mammal. For example, methods and materials for using nanoparticles to increase the half-life and the bioavailability of molecules administered to a mammal are provided.... Agent: Mayo Foundation For Medical Education And Research

20120040431 - Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites: The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may... Agent: Immunomedics, Inc.

20120040433 - Live, oral vaccine for protection against shigella dysenteriae serotype 1: The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof;... Agent: Government Of The United States Of America, As Represented By The Secretary,

20120040434 - Protein exhibiting activity of pyrethrin biosynthetic enzyme, gene encoding the protein, and vector bearing the gene: (iii) a protein consisting of an amino acid sequence including one or more of a substitution, deletion, insertion, and/or addition of amino acid in the amino acid sequence shown in Sequence No. 1, in which the protein exhibits activity of pyrethrin biosynthetic enzyme.... Agent: An Educational Foundation Kinki University

20120040435 - Novel variant hypocrea jecorina cbh2 cellulases: Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability.... Agent: Danisco US Inc.

20120040436 - type milk-clotting protease derived from a microorganism: The present invention provides an improved type protease which comprises an amino acid sequence that is at least 75% identical to SEQ ID NO:3, said improved type protease has at least one mutation selected from the group consisting of: (A) replacement of glutamine corresponding to glutamine at position 265 in... Agent: Meito Sangyo Co., Ltd.

20120040437 - Alanine 2,3-aminomutases and related polynucleotides: The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.... Agent: Codexis, Inc.

20120040438 - Novel porcine circovirus type 2b isolate and uses thereof: The present invention relates to the novel Porcine Circovirus type 2 subtype B (PCV2B-Rm) isolate which comprises a short duplication of sequence and is adapted to grow in cell culture and may be propagated at high titres constantly up to 106 TCID50 viral particles per mL. This novel isolate is... Agent: Ceva Sante Animale

20120040439 - Use of prokaryote viruses to remediate bio-fouling: This invention provides a process for control in oil and gas wells and related facilities of prokaryote caused souring, fouling and corrosion by reduction of problematic prokaryotes with naturally occurring lysing organisms, particularly sulfate-reducing prokaryotes by proliferating suitable virulent lysing organisms under conditions in which problematic prokaryotes thrive, including in... Agent: Phage Biocontrol Research, LLC

20120040440 - Engineering resistance to aliphatic alcohols: The present disclosure provides improved systems for the biological production of aliphatic alcohol compounds. In particular, the present disclosure provides biological systems that show improved resistance to aliphatic alcohol toxicity; in some embodiments, such improved resistance allows for increased levels of aliphatic alcohol production. In one aspect, the present disclosure... Agent:

20120040441 - Transformed strains originated from multidrug efflux protein defective strains and a method for microbial conversion using them: Disclosed is a means for improving the poor conversion efficiency in a conventional bioconversion system using a transformant which is given by introducing a gene originated from xerogenic organisms. A transformant is prepared by using a host which is defective in a gene encoding a multidrug efflux protein and introducing... Agent: Mercian Corporation

20120040442 - Method for use in palm oil mill effluent (pome) treatment: The present invention discloses a method for use in treating palm oil mill effluent (POME). Said method comprising the steps of: treating the palm oil mill effluents with concentrated butyrate; introducing the treated palm oil mill effluents into a reaction tank (11) with loading rate of at least 1.5 g... Agent:

20120040443 - continuous process for isolation of oils from algae or micro organisms: The present invention relates to a continuous process for isolation of oils from a micro organism slurry or an algae slurry comprising feeding the slurry into a three phase centrifugal separator having a stack of separating discs and operating under force of at least 4500 G, preferably under a force... Agent: Alfa Laval Corporate Ab

20120040444 - Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins: A method and apparatus for embedding cells that utilizes a flow-through embedding technique. The apparatus includes a cell flow pathway defined by an inflow tube for delivering cell fragments from a cell sample to a sample port. The sample port is in fluid communication with a tissue cassette having attached... Agent: University Of Massachusetts

20120040445 - Gas-free fluid chamber: A Gas-free Fluid chamber for PCR. The present invention relates to a device with a fluid chamber suitable for performing a polymerized chain reaction for gas-free filling. Such devices may be used in the field of e.g. molecular diagnostics.... Agent: Koninklijke Philips Electronics N.v.

20120040447 - Magnetic immunodiagnostic method for the demonstration of antibody/antigen complexes especially of blood groups: The invention relates to a magnetic immunodiagnostic method for the demonstration of antibody-antigen complexes. One such method involves the research and/or identification of antibodies or antigens, preferably anti-antigen antibodies or antigens of a blood group, and comprises a suspension of magnetic particles coated with antigens that can be carried by... Agent:

20120040446 - Particle agglutination in a tip: An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition... Agent: Ortho-clinical Diagnostics, Inc.

20120040448 - Microreactors with connectors sealed thereon; their manufacturing: The present invention deals with microfluidic devices (200) including a microreactor (20) and at least one connector (101) sealed thereon. It also deals with a method for manufacturing such microfluidic devices and to blocks of material suitable as connector.... Agent:

20120040449 - Disposable bioreactor and use-once stirring system: The present invention relates to a disposable bioreactor including a flexible pouch made of a polymer material and in addition a single-use stirring system placed entirely within said pouch; said stirring system comprising a drive means and at least one stirring means driven in rotation by said drive means via... Agent:

20120040450 - Apparatuses and compositions for cryopreservation of cellular monolayers: Provided are apparatuses for cryopreserving cells which include a vessel comprising a biocompatible substrate, wherein the vessel further comprises an interior and an exterior, and a mechanical ice nucleating device disposed in or on the vessel interior for initiating ice crystal formation. Also provided are kits comprising one or more... Agent: Biolife Solutions, Inc.

20120040451 - Molecules able to modulate the expression of at least a gene involved in degradative pathways and uses thereof: A molecule being able to modulate the expression of at least a gene involved in degradative pathways so to enhance the cellular degradative pathways and prevent or antagonize the accumulation of toxic compounds in a cell and acting on a CLEAR element. Preferred molecules are: the TFEB protein, synthetic or... Agent: Fondazione Telethon

20120040453 - Bioreactor using oxygen-carrying molecules: The present invention relates to devices and bioreactors capable of delivering oxygen to a cell culture using oxygen-carrying molecules. The bioreactor comprises at least two chambers separated by an oxygen-permeable membrane. The oxygen-carrying molecules are chosen from extracellular hemoglobin isolated from worm belonging to Arenicoliolae family or Nereidiolae family.... Agent: Hemarina

20120040452 - Glypican-3 (gpc3)-derived tumor rejection antigenic peptides useful for hla-a2-positive patients and pharmaceutical comprising the same: (B) a peptide, which has an amino acid sequence comprising a substitution or addition of one or two amino acids with respect to the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3, and which has ability to induce killer T cells.... Agent: Oncotherapy Science, Inc.

20120040454 - Process for producing a human t-cell population having both cytotoxic and immunosuppressive activities: )

20120040455 - Curved polyhedrons: The present invention relates to a polymer article having the shape of a curved polyhedron comprising only concave curvature faces and convex curvature edges or by also having concave curvature faces, in which a part of the concave curvature face has been replaced by a flat face, and convex curvature... Agent: Origo Biotech Aps

20120040456 - Methods of gene therapy using nucleic acid sequences for atp-binding cassette transporter: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP... Agent: Baylor College Of Medicine

20120040457 - Small molecules that replace or agonize p53 function: This invention provides a novel screening system for identifying p53 mimetics/agonists. Also provided are small organic molecules that act as effective p53 mimetics/agonists.... Agent:

20120040458 - Method for producing dendritic cells: The present inventors discovered that dendritic cells with a high IL-12 productivity can be obtained by culturing DC precursor cells in the presence of a plurality of cytokines, followed by about one week of culture in the presence of GM-CSF and IL-4. The present invention enables preparation of a large... Agent: Dnavec Corporation

20120040459 - Reduced size self-delivering rnai compounds: The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.... Agent: Rxi Pharmaceuticals Corporation

20120040460 - Ribonucleic acid interference molecules: Ribonucleic acid interference molecules are provided. In one aspect of the invention, a method for regulating gene expression comprises the following step. At least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ ID NO: 1 through SEQ ID NO: 103,948, each one... Agent: International Business Machines Corporation

20120040461 - Fabrication of nanofiber reinforced structures for tissue engineering: Disclosed are composite arrays and methods of forming the arrays. Composite arrays include a hydrogel-forming polymeric network and a network of electrospun fibers embedded within the polymeric network. For instance, the polymeric network can include one or more extracellular matrix proteins. The network of electrospun fibers can describe an open... Agent:

20120040462 - Nanofibers, nanofilms and methods of making/using thereof: Described herein are compositions for making nanofibers and nanofilms composed of metal oxides, organic polymers, or combinations thereof. Also described herein are methods for making nanofibers and nanofilms where the fibers are formed from a solution having more than one solvent, where the solvents are immiscible. Nanofibers and nanofilms composed... Agent:

20120040463 - Hollow, notably multi-membrane fibers, method for preparation thereof by spinning and device for applying said method: The present invention relates to a method for preparing fibers, notably of polysaccharide or collagen, by wet spinning under coagulation, said method notably comprising: a step for extruding a coagulable macromolecular assembly solution through a normal die; at least one partial coagulation cycle comprising a coagulation step on the one... Agent: Universite Claude Bernard Lyon I

20120040464 - Method for generating homoplasmic cells from heteroplasmic cells: The present invention relates to a method, which comprises allowing cells to come into contact with a reactive oxygen species by, for example, adding the reactive oxygen species such as hydrogen peroxide to a medium containing the cells, and then culturing the cells under suitable culture conditions, so that the... Agent: Riken

20120040465 - Modification of the genome of a lytic bacteriophage by immobilizing said bacteriophage in the host bacterium thereof: e

02/09/2012 > 106 patent applications in 66 patent subcategories. patent applications/inventions, industry category

20120034593 - Cyclic peptides with an anti-parasitic activity: The present invention relates to a method for preparing a cyclic peptide with antiparasite activity and anticancer activity. The invention also relates to this peptide as an antiparasite agent, for example in the treatment of toxoplasmosis and as an anticancer agent. The invention also relates to the use of this... Agent: Universite Joseph Fourier (grenoble 1)

20120034594 - Methylocystis strain sb2 materials and methods: wherein each of P1 and P2 is a peptide comprising at least two amino acids, M1 is a first metal binding moiety comprising a substituted imidazolone ring, M2 is a second metal binding moiety comprising a substituted oxazolone ring, and wherein M1 and M2 bind to a single metal atom.... Agent:

20120034596 - Device for automatically cultivating cells in parallel: A device for automatically cultivating cells in parallel in cell culture vessels, in particular microtiter (MT) plates (2), having a housing (23) in which are disposed an observation unit (3) comprising at least one microscope (7) and at least one camera (6), a receptacle device (4) for receiving the cell... Agent: Pan-systech Gmbh

20120034595 - Enriched stem cell and progenitor cell populations, and methods of producing and using such populations: The present invention provides a novel method to isolate and expand pure progenitor/stem cells from a primary tissue explant, which produces a population enriched in multipotent functional progenitor/stem cells free of contaminating fibroblasts and other cell types. Cardiac progenitor/stem cells isolated by this method maintain their self-renewal and clonogenic character... Agent: Keck Graduate Institute

20120034600 - Decreasing potential iatrogenic risks associated with influenza vaccines: Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realised that the conditions used for influenza virus culture can increase the... Agent:

20120034597 - Methods of monitoring treatment of aviremic hiv-infected patients: Methods of monitoring the efficacy of intensified highly active anti-retroviral therapy (HAART) treatment in aviremic Human Immunodeficiency Virus (HIV)-infected patients.... Agent: University Of Massachusetts

20120034598 - Real-time detection of influenza virus: The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection... Agent:

20120034599 - Screening systems utilizing rtp801: e

20120034601 - Porous materials for biological sample collection: Methods, apparatuses, and systems for collecting samples using hybrid porous materials that include an organic material and an inorganic material. A method for sample collection includes contacting a hybrid porous material and a biological sample to the porous material. The hybrid porous material includes an inorganic material and an organic... Agent:

20120034602 - Recombinant polymerases for improved single molecule sequencing: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the... Agent: Pacific Biosciences Of California, Inc.

20120034606 - Detection of salmonella enterica subspecies enterica serovar enteritidis in food and environmental samples, methods and compositions therefor: Embodiments of the disclosure relate to compositions of isolated nucleic acid sequences, methods, workflows and kits of use thereof for detection of Salmonella enterica, subspecies enterica, serovar Enteritidis (S. Enteritidis) in a sample, particularly in a food (egg, poultry) or environmental sample (including poultry-related environmental samples). Embodiments of the disclosure... Agent: Life Technologies Corporation

20120034609 - Gene detection assay for improving the likelihood of an effective response to an egfr antagonist cancer therapy: The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing EGFR, as determined by a gene amplification assay, with an EGFR antagonist. Such method comprises administering a cancer-treating dose of the EGFR antagonist, preferably in addition to chemotherapeutic agents, to a subject... Agent: Genentech, Inc.

20120034610 - Identification of toxin-binding protein involved in resistance to cry1 toxins, and related screening methods: The subject invention relates in part to the surprising and unexpected discovery that insects that are resistant to Bacillus thuringiensis Cry toxins have measurably altered alkaline phosphatase (ALP) activity as compared to insects that are susceptible to Cry toxins. This and other surprising discoveries reported herein have broad implications in... Agent: The University Of Georgia Research Foundation, Inc .

20120034603 - Ligation-based detection of genetic variants: The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary... Agent: Tandem Diagnostics, Inc.

20120034605 - Method for detection of colorectal tumor: Disclosed is a method for determining the presence or absence of a colorectal tumor, specifically colorectal cancer or colorectal adenoma, with high sensitivity and high specificity by employing the methylation of DNA as a measure. Also disclosed is a kit for carrying out the method. Specifically, measurement is made on... Agent: A&t Corporation

20120034607 - Methods and apparatus for measuring analytes using large scale fet arrays: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and... Agent: Life Technologies Corporation

20120034608 - Microrna as a biomarker of pancreatic islet beta-cell engagement: MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression and which play important roles in many cell types, including as described herein, the pancreatic β-cell. Glucagon like peptide-1 (GLP-1), a hormone released from intestinal L-cells following meal intake, exerts pleiotropic effects on β-cell function including raising intracellular cAMP levels... Agent: Merck Sharp & Dohme Corp.

20120034604 - Use of basic prolin-rich lacrimal gene products, such as opiorphin, as a biomarker: The present invention relates to the use of Basic Prolin-rich Lacrimal protein (BPLP) gene products, such as Opiorphin, for establishing a prognosis, a diagnosis or the monitoring of a pathological state or of treatment efficacy in a subject and the related method of use.... Agent: Institut Pasteur

20120034613 - Apparatus and method for testing relationships between gene expression and physical appearance of skin: The disclosure is directed to apparatus and methods for testing relationships between gene expression and physical appearance of skin and methods of assessing the efficacy of skin anti-aging agents.... Agent: Nse Products, Inc.

20120034614 - Early detection of pathogens in blood: The present invention is a method of extracting infectious pathogens from a volume of blood including the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The fibrin lysis reagent is preferably composed of plasminogen and streptokinase frozen... Agent: University Of South Florida

20120034615 - Hifu induced cavitation with reduced power threshold: An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample is provided. The apparatus includes a source and is adapted to receive a cartridge in such a way, that the apparatus focuses the HIFU waves emitted from the source onto a liquid air... Agent: Biocartis Sa

20120034611 - Method for detecting presumed iga nephropathy and method for screening iga nephropathy patients: Based on detection of Treponema bacteria or Campylobacter bacteria present in a sample derived from the tonsil of a subject who has a positive result on at least one of a urinary protein test and a urinary occult blood test, or of a patient diagnosed with possible IgA nephropathy, presumed... Agent: Osaka University

20120034612 - Methods and kits for mirna isolation and quantitation: The present invention is a kit and method for isolating and quantitating miRNA and to the use of such methods in the diagnosis and prognosis of disease.... Agent: University Of Medicine And Dentistry Of New Jersey

20120034616 - Method for modulating epithelial stem cell lineage: The present invention relates to methods of modulating epithelial stem cell lineage by regulating the expression of Lef1 or a BMP inhibitor and/or the stability of β-catenin or the expression of a Wnt; regulating the expression or activity of GATA-3; or regulating BMPR1A activity either at the level of receptor... Agent: The Rockefeller University

20120034617 - Assays for bacterial detection and identification: The invention herein generally relates to kits and methods for detecting the presence of a bacterium in a subject, for example, methicillin resistant S. aureus. In certain embodiments, the invention provides a method of detecting presence of a bacterium in a sample from a subject, the method including: contacting a... Agent:

20120034620 - Compositions and methods for adhesion of intact cells to an apparatus: Bio-adhesive compositions that include an extra-cellular matrix protein, bovine serum albumin conjugated with a fluorophore, and an aggregate are provided. The bio-adhesive composition may also include at least one component selected from the group consisting of collagen type IV, laminin, and chitosan. Also provided are methods of making the present... Agent: University Of Maryland, Baltimore

20120034619 - Method of determining the oligomeric state of a protein complex: A method of counting protein subunits to determine the oligomeric state of an oligomeric protein complex includes tagging and expressing the protein subunits with a mass/charge tag and selectively removing each mass/charge tag. The number of protein subunits of the oligomeric complex corresponds to the number of mass/charge tags removed.... Agent:

20120034618 - Methods for culture and production of single cell populations of human embryonic stem cells: We used ACCUTASE®, a commercially available cell detachment solution, for single cell propagation of pluripotent hESCs. Unlike trypsin dissociation, ACCUTASE® treatment does not significantly affect the plating efficiency of hESC dissociation into single cells. Cultures dissociated with ACCUTASE® to single cells at each passage maintain a higher proportion of pluripotent... Agent: Sanford-burnham Medical Research Institute

20120034621 - Microorganism concentration process and device: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of... Agent:

20120034622 - Activation and monitoring of cellular transmembrane potentials: The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed.... Agent: Life Technologies Corporation

20120034623 - Up-concentration of organiz microobjects for microscopic imaging: A method of analyzing a sample fluid containing organic microobjects is proposed. The method comprises the steps of: up-concentrating (S1) the microobjects by removing, in a total time T1, a volume V1 of the sample fluid from the upconcentrate sample microobjects; immersing (S2) the microobjects in a transfer fluid, or... Agent: Koninklijke Philips Electronics N.v.

20120034625 - Monoclonal antibody capable of binding integrin alpha 10 beta 1: The present invention provides a monoclonal antibody or a fragment thereof binding to the extracellular I-domain of integrin alpha10beta1 and a hybridoma cell line deposited at the Deutsche Sammlung von Microorganismen and Zellkulturen GmbH under the accession number DSM ACC2583. Furthermore, the present invention also provides a monoclonal antibody or... Agent: Xintela Ab

20120034627 - Diagnosis of benign and cancerous growths by measuring circulation tumor stem cells and serum annexina2: Provided herein is a method for diagnosing/prognosing a metastatic cancer in a subject by measuring and detecting one or more of CS-ANXA2, DCAMKL, Lgr5 or CS-ANAX2 and DCAMKL or CS-ANXA2 and Lgr5 positive circulating tumor stem cells in the subject's blood or plasma. Also provided is a method for distinguishing... Agent:

20120034626 - Neoplasia-specific autoantibodies and methods: ENOX2 proteins are growth-related cell surface proteins expressed specifically by cancer cells; they catalyze NADH oxidation and protein disulfide-thiol interchange reactions. Taught herein are IgM class autoantibodies specific to ENOX2 (tNOX) in a variety of cancer patient sera. Early cancer patients produce these autoantibodies as a possible defense mechanism. Because... Agent:

20120034628 - Standardized evaluation of therapeutic efficacy based on cellular biomarkers: The present invention provides materials and methods for predicting the response of a disease state to a therapeutic agent. A targeting moiety specific for a biological marker is labeled with a reporter moiety and used to analyze cells characteristic of the disease state. The output of the reporter moiety, which... Agent: On-q-ity Inc.

20120034624 - Oscillating immunoassay method and device: The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.... Agent: Abbott Point Of Care Inc.

20120034630 - Circovirus sequences associated with piglet weight loss disease (pwd): The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a... Agent: Wyeth LLC

20120034629 - Prediction of non-fatal and fatal atherothrombotic events: The present invention relates to methods and systems for the prediction of atherothrombotic events in human subjects. Preferably the human subjects are afflicted with a cardiovascular disease, such as end-stage renal disease. Methods and systems of the invention are particularly suited to predict atherothrombotic events in patients on hemodialysis.... Agent: Siemens Healthcare Diagnostics Inc.

20120034631 - Anti-lysophospholipid antibody design using antibody structures: The present invention provides crystalline forms of an anti-LPA antibody or fragment thereof, which may further comprise a lipid ligand of said antibody and/or salts, metals, or co-factors. Methods for making such crystals and co-crystals are provided, as are methods of using structural information in antibody design or optimization. Methods... Agent:

20120034632 - Two-phase optical assays for analytes of no intrinsic opitcal contrast: Methods and kits for performing a two-phase optical assay for one or more than one analyte without intrinsic optical contrast in a sample are disclosed. The method requires use of a functionalized microparticle immobilized with two or more than functional components and an additional set of one or more than... Agent:

20120034633 - Magnetic immunosensor and method of use: The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.... Agent: Abbott Point Of Care

20120034635 - Method for amplifying adenosine triphosphate and method and reagent for detecting the concentration of microorganisms: A method for amplifying adenosine triphosphate is provided, including mixing adenosine triphosphate sulfurylase, adenosine 5′ phosphosulfate, adenylate kinase, uridine triphosphate, acetate kinase, acetyl phosphate, luciferin and luciferase in the presence of ATP to form a mixture, and reacting the mixture to amplify ATP. A method and reagent for detecting a... Agent: Industrial Technology Research Institute

20120034634 - Modified luciola cruciata luciferase protein: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed.... Agent:

20120034636 - Chemical sensing device: This invention relates to a chemical sensing device for detecting an analyte. The device comprises a light source, at least one luminescent reagent which is capable of luminescing when irradiated by the light source wherein the luminescence of the luminescent reagent is modifiable by the analyte thereby changing the generation... Agent: Vivacta Limited

20120034637 - Detection of trichomonas and candida: The invention relates to a method and a kit for the detection of Trichomonas infection by detecting N-acetyl-β-D-hexosaminidase activity. The invention also relates to a method and a kit for selective detection of presence of Trichomonas or Candida infection.... Agent:

20120034638 - Electrochemical assay for the detection of enzymatically active psa: The present invention is directed to the diagnosis of cancer associated with enzymatically active PSA in samples.... Agent:

20120034639 - Analyte detection: The present invention relates to analyte detection test systems, including test systems for the oral detection of analytes in saliva. The present invention also provides compositions and methods for storing multiple assay tests and compositions and methods for measuring the concentration of analytes in a sample.... Agent: N2itive1 Innovations

20120034641 - Biological information acquisition method: A biological information acquisition method includes: measuring an amount of nicotinamide metabolite in a sample collectable from a living organism in a minimally invasive manner; and acquiring information concerning the living organism based on the measured amount of nicotinamide metabolite.... Agent: Sony Corporation

20120034643 - Fluorescent protein: An object of the present invention is to provide a red or orange fluorescent protein, which is characterized in that the difference (stokes shift) between an excitation peak value (wavelength of maximum absorption) and a fluorescence peak value (wavelength of maximum fluorescence) is greatened, so that the maximum fluorescence can... Agent: Riken

20120034644 - Identifying material from a breast duct: Methods and systems for identifying material from a breast duct using one or more markers that can be identified in ductal fluid retrieved from the breast are provided.... Agent: Atossa Genetics, Inc.

20120034640 - Isotonic buffered composition and method that enables counting of cells: The present invention discloses multi-purpose metering fluid/rinse reagents for use in automated cellular analyzers that use liquid volumetric metering. The compositions contain a chelating agent, an ionizing salt, optionally a stabilizing ion, a buffer, a non-hemolytic surfactant, and optionally an antimicrobial agent. Advantageously, the compositions produce less than one part-per-million... Agent: Beckman Coulter, Inc.

20120034645 - Method and apparatuses for conducting assays: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration... Agent: Meso Scale Technologies, LLC.

20120034642 - Method for obtaining a singular cell model capable of reproducing in vitro the metabolic idiosyncrasy of humans: The method is based on the use of expression vectors coding for the sense and anti-sense mRNA of the Phase I and Phase II drug biotransformation enzymes showing a greatest variability in humans for transforming cells expressing reductase activity. Such vectors can modulate (increase or decrease) the individualized expression of... Agent: Advanced In Vitro Cell Technologies, S.l.

20120034646 - Detection of h. pylori utilizing unlabeled urea: Disclosed is a method and device for detection of H. Pylori in breath emissions utilizing an unlabelled urea, in which a patient ingests a safe quantity of unlabelled urea. After ingestion, expired breath of the patient is analyzed for ammonia, with a detection based on levels of ammonia lower than... Agent:

20120034647 - Method and apparatus for automated whole blood sample analyses from microscopy images: A method and apparatus for identifying one or more target constituents (e.g., white blood cells) within a biological sample is provided. The method includes the steps of: a) adding at least one colorant to the sample; b) disposing the sample into a chamber defined by at least one transparent panel;... Agent: Abbott Point Of Care, Inc.

20120034648 - Pentose sugar fermenting cell: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous... Agent: DsmIPAssets B.v.

20120034649 - Microorganism and method for producing canthaxanthin: A carotenoid producing bacterium belonging to the genus Paracoccus that selectively produces canthaxanthin so that the amount thereof is not less than 90 percent by weight of the total amount of produced carotenoids including β-carotene, β-cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3′-hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin, and astaxanthin. A method for producing canthaxanthin... Agent: Tosoh Corporation

20120034650 - Nucleic acid molecule of a biosynthetic cluster encoding non ribosomal peptide synthases and uses thereof: The present invention relates to the provision of a polynucleotide comprising one or more functional fragments of a biosynthetic gene cluster involved in the production of a compound of formula (I) or (I′). The present invention also provides a method of preparing a compound of formula (I) or (I′) or... Agent: Novartis Ag

20120034651 - Akt activity specifically inhibiting polypeptide: The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor agent, and the like. The polypeptide comprises polypeptides (SEQ ID NO: 1, 3, 5, 7, and 9 of the... Agent:

20120034652 - Method for the targeted integration of multiple copies of a gene of interest in a yarrowia strain: This invention concerns a method for the targeted integration of at least three copies of a gene of interest in the genome of a Yarrowia strain including the steps of: (a) cultivating a Yarrowia strain, said strain including a deletion among at least three genes, the phenotype associated with each... Agent:

20120034654 - Method for transforming schizosaccharomyces pombe, transformant of schizosaccharomyces pombe and method for producing heterologous protein: A method for transforming Schizosaccharomyces pombe by using a vector carrying an expression cassette (containing a promoter capable of functioning in Schizosaccharomyces pombe, a heterologous protein structural gene and a terminator), and having recombination region(s) at which homologous recombination with each chromosome of Schizosaccharomyces pombe is to be achieved, which... Agent: Asahi Glass Company, Limited

20120034653 - Trophic conversion of obligate phototrophic algae through metabolic engineering: Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human... Agent: Martek Biosciences Corporation

20120034655 - Fsh producing cell clone: The present invention relates to nucleic acid molecules comprising a nucleic acid sequence coding for the α- and the β-chain of the human follicle stimulating hormone (FSH), respectively, which has been modified with respect to the codon usage in CHO cells. The present invention further relates to a recombinant nucleic... Agent: Biogenerix Ag

20120034656 - Neutralising antibody molecules having specificity for human il-17: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.... Agent: Ucb Pharma S.a.

20120034657 - Thrombopoietic compounds: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.... Agent: Amgen Inc.

20120034658 - Methods for creating color variation in anthocyanins produced by cell culture: Disclosed are methods for obtaining blue anthocyanin pigments and compositions including such pigments. This blue anthocyanin is present at an acidic pH (where anthocyanins are most stable) and may be used as a natural color additive. The methods can include cultivating a plant callus from a plant capable of producing... Agent: Dianaplantsciences, Inc.

20120034659 - Neutral ph saccharification and fermentation: Embodiments of the present disclosure relate to a process for producing downstream products, such as fermentable sugars and end products, from a starch substrate by saccharification and/or fermentation. The saccharification is effectively catalyzed by a glucoamylase at a pH in the range of 5.0 to 8.0. At a pH of... Agent: Danisco US Inc.

20120034660 - Process for producing optically active succinimide derivatives and intermediates thereof: A process for producing optically active succinimide derivatives as key intermediates of (3R)-2′-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4′(1H)-pyrrolo[1,2-a]pyrazine}-1′,2,3′,5(2′H)-tetraone, which comprises the following reaction steps.... Agent: Dainippon Sumitomo Pharma Co., Ltd.

20120034661 - Strains for the production of flavonoids from glucose: The invention relates to the production of flavonoids and flavonoid precursors in cells through recombinant expression of tyrosine ammonia lyase (TAL), 4-coumarate:CoA ligase (4CL), chalcone synthase (CHS), and chalcone isomerase (CHI).... Agent: Massachusetts Institute Of Technology

20120034662 - Co-culturing algal strains to produce fatty acids or hydrocarbons: The present invention provides methods and compositions for production of algal-based medium chain fatty acids and hydrocarbons.... Agent:

20120034663 - Methods and systems for biomass conversion to carboxylic acids and alcohols: The disclosure includes a method, process and apparatus for the conversion of biomass to carboxylic acids and/or primary alcohols. The system may include a pretreatment/fermentation subsystem operable to produce a fermentation broth containing carboxylic acid salts from biomass, such as lignocellulosic biomass. The system may also include a dewatering subsystem... Agent: The Texas A&m University System

20120034664 - Process to produce organic compounds from synthesis gases: At least one isolated microorganism and a fermentation method to convert hydrogen gas, carbon dioxide gas, and/or carbon monoxide gas to a lower alkyl alcohol and/or carboxylic acid and to produce at least 2% by volume of the lower alkyl alcohol or carboxylic acid in an aqueous-based medium.... Agent:

20120034665 - Enzymatic method for producing aldehydes: The invention relates to methods for producing aldehydes and the oxidation and reduction products thereof.... Agent: Evonik Degussa Gmbh

20120034666 - Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids: The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or... Agent: Gevo, Inc.

20120034667 - Method for recovering and producing ethanol and oil: To provide a method for producing an ethanol which facilitates the processing of a solid component as a residue generated upon processing, while improving the recovery rate of heat energy contained in leftover food. The method for recovering and producing ethanol and oil is a method for producing ethanol by... Agent:

20120034668 - Novel nitrate reductase fusion proteins and uses thereof: The present invention relates to a novel fusion protein comprising a nitrate reductase (NR) and a truncated hemoglobin N (trHbN) domain. The fusion protein may be used for bioremediation of nitric oxide.... Agent: University Of Delaware

20120034669 - Process for producing useful substance: The present invention provides a process for producing a useful substance which comprises culturing a transformant obtained by transforming a microorganism capable of producing the useful substance with a DNA encoding a protein in a medium, wherein the protein has an activity to improve growth of a high concentration oxygen-requiring... Agent: Shinshu University

20120034670 - Organic-inorganic composite material and process for producing same: Disclosed is an organic-inorganic composite material obtained by chemically modifying a microorganism-derived ceramic material with an organic group, and a process for producing the organic-inorganic composite material. The process is characterized by reacting a microorganism-derived ceramic material with at least one compound selected from the group consisting of silane coupling... Agent:

20120034671 - Protein matrix for light-initiated electron transfer: The present invention provides selective modification of polypeptide sequences with electron transfer moieties. The resulting polypeptide assemblies represent a novel class of electron transfer complexes that are capable of transferring electrons over very long distances at fast rates. These complexes possess unique structural features which enable the production of bioconductors... Agent: Research Foundation Of The City University Of New York

20120034672 - Superluminescent luciferase variant with prolonged bioluminescence: This invention provides a genetically modified marine luciferase such as Gaussia luciferase, which has high bioluminescence intensity, and has high bioluminescence stability and/or red-shifted wavelength. Specifically disclosed is a luciferase variant with improved optical property obtained by replacing at least one amino acid residue among the amino acid sequence of... Agent:

20120034673 - Isolated plant deoxyhypusine synthase and nucleotides encoding same: Regulation of expression of programmed cell death, including senescence, in plants is achieved by integration of a gene or gene fragment encoding senescence-induced deoxyhypusine synthase, senescence-induced eIF-5A or both into the plant genome in antisense orientation. Plant genes encoding senescence-induced deoxyhypusine synthase and senescence-induced eIF-5A are identified and the nucleotide... Agent:

20120034674 - Method of producing recombinant adamts13 in cell culture: Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a high specific activity and ADAMTS13 with a high specific activity. The cell culture conditions of the present invention can include, for example, a cell culture medium with... Agent: Baxter International Inc.

20120034675 - Tyrosinase mutant and methods of use thereof: The present invention describes a novel tyrosinase protein and methods of use thereof. Specifically, the invention provides tyrosinase derived peptides and polynucleotides, and their ability to elicit an immune response and treat a melanoma.... Agent: United Therapeutics

20120034677 - Microorganism culture device and method of operation thereof: The invention is directed to a microorganism culture device (100), such as a micro fluidic cell culture device. The device comprises an open chamber (10), wherein microorganisms are likely to be deposited within a liquid for subsequent study. The open chamber simplifies the deposition of the microorganisms. The chamber is... Agent: New Orchard Road

20120034676 - Seneca valley virus based compositions and methods for treating disease: The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill... Agent:

20120034678 - Diaryl ethers: e

20120034679 - Method and apparatus for cultivation of algae and cyanobacteria: The invention relates to a method of cultivation of algae or cyanobacteria in the presence of a luminous material that converts light of a first wavelength to a second wavelength more suitable for use in photosynthesis by the algae or cyanobacteria, and apparatus for performing the method. In one embodiment... Agent: Zero Discharge Pty Ltd,

20120034680 - Process for treating carbon dioxide containing gas: A process is disclosed for recycling carbon dioxide emissions from a fossil-fuel power plant into useful carbonated species The process primarily comprises the steps of: a) burning the fossil fuel, thereby generating heat and a hot exhaust gas containing CO2; and b) converting the heat into energy. The process is... Agent: Co2 Solution Inc.

20120034681 - Digester for high solids waste: A digester with separate stages for hydrolysis and methanogenesis is disclosed. The digester includes a leachate bay reactor, which may be configured as modular, multi-bay units. Waste material is added to the leachate bay reactor. A leachate storage tank is fluidically connected to the leachate bay reactor, which facilitates hydrolysis.... Agent:

20120034682 - Process for separating high purity germ and bran from corn: A semi-wet process for refining corn to make a feedstock for ethanol production. Corn is tempered at a moisture content from about 20-25% by weight for a very short time followed by grinding. The ground corn is not dried and cooled before further processing. It is graded and then ground... Agent:

20120034683 - Petroleum bioconversion of organic acids to prevent refinery corrosion: The present invention relates to the use of microorganisms (biocatalysts), or catalysts derived from these organisms (enzymes), to improve the quality of crude oil and bitumen as an attractive alternative to current upgrading methods. The invention identifies and characterizes the microorganism species, in particular, N. muscorum (UTEX 2209) and Kocuria... Agent: Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Natural Resources

20120034685 - Assay systems for determination of source contribution in a sample: The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.... Agent: Tandem Diagnostics, Inc.

20120034686 - Devices and methods for dual excitation raman spectroscopy: Spectroscopic analysis systems and methods for analyzing samples are disclosed. An analysis system may contain an electromagnetic radiation source to provide radiation, a spectroscopic analysis chamber to perform a coherent Raman spectroscopy (e.g., stimulated Raman or coherent anti-Stokes Raman spectroscopy), and a radiation detector to detect radiation based on the... Agent:

20120034684 - Magnetic immunosensor with trench configuration and method of use: The present invention provides apparatus and methods for the rapid determination of analytes in liquid samples by immunoassays incorporating magnetic capture of beads on a sensor capable of being used in the point-of-care diagnostic field.... Agent: Abbott Point Of Care

20120034687 - Protection of bioanalytical sample chambers: An apparatus for performing bioanalytic processing and analysis, a bioanalytical reaction device, and a cartridge thereof are provided. The cartridge contains a housing and at least one sample chamber in a platform for storing biological samples, which the bioanalytical reaction device can process and analyze. The platform is movably connected... Agent: Biocartis Sa

20120034688 - True nucleic acid amplification: A system and method directed to DNA amplification with optional in situ purification, sequencing and/or detection, or a system compatible with integrated, post-amplification purification and or sequencing by capillary electrophoresis and other methods. The device is a single, helical channel formed of fused silica with heat zones defined about fixed... Agent:

20120034689 - Mycobacterial antigens expressed during latency: A method is provided for identifying mycobacterial genes that are induced or up-regulated under culture conditions that are nutrient-starving and which maintain mycobacterial latency, said conditions being obtainable by batch fermentation of a mycobacterium for at least 20 days post-inoculation, when compared with culture conditions that are not nutrient-starving and... Agent:

20120034690 - Cell lines producing blocking antibodies to human rankl: Described herein are cell lines and methods for preparing antibodies that bind RANKL, including cell lines that produce blocking antibodies to human RANKL.... Agent: Immunex Corporation

20120034691 - Genetically encoded calcium indicators and methods of use: Provided herein are nucleic acid sequences and polypeptides encoding a genetically encoded calcium indicator (GECI). Also provided are vectors and cells comprising the nucleic acid sequences and/or polypeptides. Kits comprising the nucleic acid sequences, polypeptides, vectors, cells and combinations thereof are also provided. Also provided herein are methods of screening... Agent:

20120034692 - Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.... Agent:

20120034693 - Recombinant vector and use in gene therapy: A recombinant vector for delivering A3G genes into human cells comprising (i) a gene expression block including an A3G gene selected from a wild type A3G gene represented by SEQ ID NO: 1 and a mutant A3G gene and (ii) a group of elements from a modified lentiviral vector including... Agent:

20120034694 - Cell culture support and cell culture method: The present invention relates to a cell culture support for culturing mesenchymal stem cells, which includes en upper surface including a plurality of wells, in which the upper surface has a root mean square roughness Rq of 100 to 280 nm and a linear density of 1.6 to 10 per... Agent: Covalent Materials Corporation

20120034695 - Tissue/cell culturing system and related methods: A system for culturing cells and/or tissue includes a tissue/cell culture chamber including a tissue/cell culture membrane, at least one collapsible valve fluidly coupled with the tissue/cell culture chamber, a pump fluidly coupled with the tissue/cell culture chamber, and a flow loop including the pump, chamber, and collapsible valve fluidly... Agent:

20120034696 - Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures: Particular aspects provide compositions comprising an electrokinetically altered oxygenated aqueous fluid, wherein the oxygen in the fluid is present in an amount of at least 25 ppm. In certain aspects, the electrokinetically altered oxygenated aqueous fluid comprises electrokinetically modified or charged oxygen species present in an amount of at least... Agent: Revalesio Corporation

20120034697 - In vitro methods for the induction and maintenance of plant cell lines as single suspension cells with intact cell walls, and transformation thereof: The subject invention provides simple and consistent methods to break suspension cell aggregates to single cells with intact primary cell walls. The subject invention relates in part to cell separation of suspension cell aggregates cultured in medium containing pectin-degrading enzymes or tubulin de-polymerizing compounds including colchicine. The subject invention also... Agent: Dow Agrosciences LLC

20120034698 - Compositions and methods for increasing oil content in algae: The present invention provides methods and compositions for increasing oil content in algae. More particularly, the present invention relates to enhancement of phytohormone activity in algae, by genetic transformation thereof or by supplementing the algal growth medium with phytohormones, to maximize the production of oil within the algae cells.... Agent: Rosetta Green Ltd.

02/02/2012 > 125 patent applications in 73 patent subcategories. patent applications/inventions, industry category

20120028234 - Tissue and organ graft bioreactor and method of operation: A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a single-use or disposable format; and operation as a stand-alone unit... Agent:

20120028235 - Resuscitation fluid: A method for treating conditions related to lack of blood supply with a lipid based resuscitation fluid is disclosed. The resuscitation fluid contains a lipid component and an aqueous carrier. The lipid component forms an emulsion with the aqueous carrier. The resuscitation fluid can be used to increase the blood... Agent:

20120028236 - Composition for preserving platelets and methos of use thereof: A platelet preservation composition is disclosed. The composition comprises a photosensitizer, an inhibitor of platelet activation, and/or an anticoagulant. The preservation composition allows inactivation of pathogens in a platelet preparation while maintaining the functionality of the platelets.... Agent: Biovec Transfusion, LLC

20120028237 - Animal cell colony picking apparatus and method: Animal cell colonies are picked up automatically by an apparatus having a picking head with a plurality of hollow pins and an integrated imager for capturing an image of adherent or non-adherent animal cell colonies held in liquid or semi-solid medium. Image processing identifies the locations of the animal cell... Agent: Genetix Ltd.

20120028238 - Animal cell colony picking apparatus and method: Animal cell colonies are picked up automatically by an apparatus having a picking head with a plurality of hollow pins and an integrated imager for capturing an image of adherent or non-adherent animal cell colonies held in liquid or semi-solid medium. Image processing identifies the locations of the animal cell... Agent: Genetix Ltd.

20120028239 - Animal cell colony picking apparatus and method: Animal cell colonies are picked up automatically by an apparatus having a picking head with a plurality of hollow pins and an integrated imager for capturing an image of adherent or non-adherent animal cell colonies held in liquid or semi-solid medium. Image processing identifies the locations of the animal cell... Agent: Genetix Ltd.

20120028240 - Animal cell colony picking apparatus and method: Animal cell colonies are picked up automatically by an apparatus having a picking head with a plurality of hollow pins and an integrated imager for capturing an image of adherent or non-adherent animal cell colonies held in liquid or semi-solid medium. Image processing identifies the locations of the animal cell... Agent: Genetix Ltd.

20120028241 - Assay system for monitoring the effects of genetically engineered cells to alter function of a synctium: This invention provides methods for determining the ability of a gene construct to alter the rhythm and contractility of a syncytial cell. Furthermore, this invention provides methods for constructing a gene construct capable of altering the rhythm or contractility of a syncytial cell. Finally, this invention provides a method for... Agent: The Research Foundation Of State University Of New York

20120028243 - Amplification genique statistique pour l'identification sans a priori de micro-organismes par sequencage sans etape de clonage: A pair of hexamers and a pair of primers specifically for identifying, without preconceptions, microorganisms in a sample, and a method for identifying one or more microorganisms, and a microorganism identification kit that uses the abovementioned hexamers and primers.... Agent: Etat Francais Represente Par Le Delegue General Pour L'armement

20120028244 - Anti-viral azide containing compounds: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as... Agent: Life Technologies Corporation

20120028242 - Biosensor for detecting multiple epitopes on a target: The present invention encompasses a method for detecting a target comprising a repeating epitope.... Agent: Saint Louis University

20120028246 - Kit for detecting highly pathogenic avian influenza virus subtype h5n1: Disclosed by the invention are an immunoassay kit and an immunoassay method for detecting highly pathogenic avian influenza virus subtype H5N1 rapidly, conveniently and specifically. Also disclosed are an immunochromatographic detection kit and an immunochromatographic detection method for detecting the virus subtype H5N1 rapidly, conveniently and specifically. It is found... Agent: Osaka University

20120028247 - Plasmon sensor and manufacturing method therefor, and method for inserting sample into plasmon sensor: A plasmon sensor includes a first metal layer and a second metal layer having an upper surface facing a lower surface of the first metal layer. The upper surface of the first metal layer is configured to receive an electromagnetic wave. A hollow space is provided between the first and... Agent: Panasonic Corporation

20120028245 - Quantitative analyte assay device and method: The present invention relates to a quantitative assay device and a method for the determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the... Agent:

20120028249 - Anthraquinone based near ir emitting compounds and uses thereof: Disclosed are near IR emitting fluorescent compounds; methods of making and kits containing the described compounds; and their use in fluorescence-based detection of biological materials.... Agent: Life Technologies Corporation

20120028248 - Engineered fluorescent dye labeled nucleotide analogs for dna sequencing: Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the nucleotide analogs. Kits, methods and systems are provided for analysis of nucleoc acid synthesis reactions.... Agent: Pacific Biosciences Of California, Inc.

20120028251 - Methods and articles for detecting deoxyribonuclease activity: The disclosure provides articles and methods useful for detecting a discrete source of DNase activity. DNase-producing microorganisms can be detected. The device can further include selective agents and/or indicators to differentiate groups or species microorganisms. Methods of use include detecting or enumerating DNase-producing microorganisms.... Agent:

20120028250 - Mitigation of photodamage in analytical reactions: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage... Agent: Pacific Biosciences Of California, Inc.

20120028255 - High yielding soybean plants with low linolenic acid: The invention overcomes the deficiencies of the prior art by providing methods for marker assisted selection to create plants of a soybean variety that exhibit a mid/low linolenic acid content with a commercially significant yield and an agronomically elite phenotype. The invention also provides derivatives and plant parts of these... Agent:

20120028252 - Human mena isoforms serve as markers of epithelial to mesenchymal transition and sensitivity to egfr inhibition in human cancer cells: The present invention discloses a method for discriminating between sensitive and resistant tumours to a treatment with EGFR inhibitor drugs comprising: in vitro testing whether tumour material expresses the hMena+11a splicing variant of hMe-na, the tumour positive to said testing being sensitive to the treatment.... Agent:

20120028253 - Method for amplifying oligonucleotide and small rna by using polymerase-endonuclease chain reaction: A method for amplifying oligonucleotide in vitro by polymerase-endonuclease chain reaction (PECR) which utilizes a single-stranded DNA probe containing repeat sequences, extends a target oligonucleotide by a thermostable DNA polymerase, cleaves extended products with a thermostable endonuclease, and amplifies target oligonucleotide by thermocycling. In PECR, a specific oligonucleotide is exponentially... Agent:

20120028256 - Method for providing information on antidepressant therapeutic effect using single nucleotide polymorphism: Disclosed is a method for providing information on the therapeutic effect of an SSRI antidepressant by identifying TPH2 gene polymorphism rs4760815, SLC6A4 gene polymorphism 5-HTTLPR, SLC6A4 gene polymorphism rs2066713, GAD1 gene polymorphism rs3828275, and GRIK2 gene polymorphism rs543196. Through the disclosed method, it is possible to select an antidepressant based... Agent: Samsung Life Welfare Foundation

20120028254 - Snp marker of breast and ovarian cancer risk: The invention provides methods for predicting an increased risk or probability of developing breast or ovarian cancer in a patient based upon the patient's KRAS-Variant and BRCA status.... Agent:

20120028259 - Compositions for improving gene amplification: The present invention generally relates to amplfication reactions. One aspect of the invention provides amplification reaction enhancer compositions comprising trehalose, carnitine, and a non-ionic detergent, such as NP40. These enhancer compositions can improve efficiency, specificity, and sensitivity of amplification reactions in conventional and real-time PCR and RT-PCR. In addition, these... Agent: Dna Polymerase Technology Inc.

20120028257 - Modified luciola cruciata luciferase gene and protein: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed.... Agent: Marker Gene Technologies, Inc.

20120028261 - Protein biomarkers for soft tissue disease diagnosis and as therapeutic targets for oral care intervention: Methods for identifying compounds useful for treating diseases or conditions of the oral cavity are described herein.... Agent: Colgate-palmolive Company

20120028260 - Rad9 as a diagnostic, prognostic and therapeutic tool for prostate cancer: This disclosure provides a method of treating a human subject having a cancer which comprises administering to the subject a nucleic acid so as to inhibit expression of human RAD9 protein in a cell of the cancer so as to thereby treat the human subject. This disclosure also provides methods... Agent: The Trustees Of Columbia University In The City Of New York

20120028258 - Receptor gene screening for detecting or diagnosing cancer: Compositions and methods that use the body's natural secretory immune system in a new way against steroid hormone responsive tumors of the breast and prostate, as well as other glandular/mucus epithelial tissues such as colon, ovary, endometrium, kidney, bladder, stomach, pancreas and secretory pituitary gland are provided. Also provided are... Agent:

20120028262 - Genes and polypeptides relating to human pancreatic cancers: The present application provides novel human genes C1958V1 or C1958V2 whose expression is markedly elevated in pancreatic cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of pancreatic cancer, and as target molecules for developing drugs against... Agent: Oncotherapy Science, Inc.

20120028263 - Method for screening a salty taste modulating substance: By contacting a test substance with a cell that expresses a Kv3.2 protein, and comparing observed cation influx into the cell with cation influx into the cell observed when the test substance is not contacted with the cell, a salty taste modulating substance such as salt alternative compound, or salt... Agent: Ajinomoto Co., Inc.

20120028264 - Method for using gene expression to determine prognosis of prostate cancer: Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence... Agent:

20120028272 - Device and methods for isolating cells: The invention provides a device and methods for separating and isolating cells.... Agent: University Of Louisville Research Foundation, Inc.

20120028266 - Discovery of candidate biomarkers of in vivo apoptosis by global profiling of caspase cleavage sites: The present invention relates to the discovery of novel biomarkers of in vivo apoptosis based on a large number of caspase-like cleavage sites. These biomarkers are useful for detection and quantification of apoptosis in a biological sample. The invention also provides synthetic peptides and proteins corresponding to neo-epitopes created by... Agent: The Regents Of The University Of California

20120028270 - Metal-enhanced bioluminescence: an approach for monitoring biological bioluminescent processes: The present invention relates to surface plasmon-coupled bioluminescence, wherein bioluminescent emission from a bioluminescent chemical reaction couples to surface plasmons in metallized particles thereby enhancing the signal. Importantly, these plasmonic emissions emitted from metallic particles generated without an external excitation source but instead from induced electronically excited states caused by... Agent:

20120028267 - Method for increasing sensitivity using linker and spacer in carbon nanotube-based biosensor: Disclosed is a method of detecting even a very small amount of a target substance by mixing a linker and a spacer at a suitable ratio and immobilizing the mixture on the surface of carbon nanotubes in a carbon nanotube-based biosensor. This method detects a specific substance at the level... Agent: M.i. Tech Co., Ltd.

20120028268 - Method of predicting acute appendicitis: Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers: leucine-rich α-2-glycoprotein (LRG); S100-A8 (calgranulin); α-1-acid glycoprotein 1 (ORM); plasminogen (PLG); mannan-binding lectin serine protease 2 (MASP2); zinc-α-2-glycoprotein (AZGP1); Apolipoprotein D (ApoD); and α-1-antichymotrypsin (SERPINA3); are increased... Agent: Children's Medical Center Corporation

20120028271 - Methods and kit for detecting breast cancer: The present inventions relates to kits and methods for diagnosing and monitoring breast cancer. An increase in the level or activity of proteins of the ubiquitin/proteasome pathway, and ancillary proteins thereof, as compared to normal control or benign tissue is indicative of breast cancer.... Agent: University Of Medicine And Dentistry Of New Jersey

20120028269 - Methods for detection of gastric cancer: The invention is directed to non-invasive methods of detecting gastric cancer in an individual in need thereof comprising determining an expression level of inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) in the individual and comparing the expression level to a control, wherein an increase in the expression level of ITIH3 in... Agent: National University Of Singapore

20120028265 - Methods of using ret nanosensors: The present invention provides methods for detecting and monitoring metabolite concentrations, which comprise detection and measurement of Fluorescence Resonance Energy Transfer upon ligand binding. The methods of the present invention are useful for real time monitoring of changes in metabolite levels in living cell cultures.... Agent:

20120028273 - Particle analysis assay for biomolecular quantification: A method is provided for carrying out multi-step separations of objects bearing at least two binding sites. In the first step, a first binder/bead composition is bound to objects that bear the first binding site, and then unbound objects, i.e. objects not bearing the first binding site, are separated from... Agent:

20120028275 - Biomimetic membrane for cell expansion: The invention relates to a membrane which can be used for cultivating adherent or suspension cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells due to modification of the membrane surface with a combination of at least one extracellular matrix protein, at... Agent: Gambro Lundia Ab

20120028276 - Methods for diagnosis of myelodysplastic syndromes (mds): The present invention relates to methods and kits for diagnosing, ascertaining the clinical course of myelodysplastic syndrome (MDS) and ascertaining response to a therapy regimen of myelodysplastic syndrome. Specifically the invention provides methods and kits useful in the diagnosis and determination of clinical parameters associated with MDS based on surface... Agent:

20120028277 - Preparation method: A method of performing an immunologic evaluation of a subject, comprising collecting a whole blood sample from the subject, maintaining the sample for at least 6 hours after collection, purifying a population of cells comprising lymphocytes and antigen presenting cells from the maintained sample, optionally by a process incorporating a... Agent:

20120028274 - Protein kinase c gamma as a biomarker for neuropsychological and cognitive functions in the central nervous system: Embodiments of the present invention are directed to a biological marker, the gamma isoform of protein kinase C (PKCg), which surprisingly allows rapid identification of compromised cognitive, behavioral, and neuropsychological functions under conditions associated with acute, transient hypoxia in humans. It was surprisingly discovered that PKCg is released from neural... Agent:

20120028279 - Biomarker for monitoring patients: The present invention is in the field of immunotherapy and relates to methods for determining the efficacy of certain immunotherapy treatments. The methods of the invention include measuring special biomarker at some time following the initiation of immunotherapy treatment to evaluate the clinical outcome of the said treatment. The invention... Agent:

20120028278 - Cell lines expressing guanylate cyclase-c and methods of using them: Cell lines that stably express GC-C and methods for using those cell lines are disclosed herein. The invention includes cell lines that express GC-C and techniques for creating cell lines. The GC-C-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results in cell-based assays, e.g., high throughput screening... Agent: Chromocell Corporation

20120028280 - Xanthurenic acid derivative pharmaceutical compositions and methods related thereto: l

20120028281 - Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine-mediated toxicity: The present invention relates to diagnostic methods for determining migration inhibitory factor (MIF) mRNA content in a sample, wherein MIF is human MIF polypeptide having a molecular weight of approximately 12.5 kDa and kits for detecting MIF.... Agent:

20120028282 - Biosensor system and method for measuring concentration of analyte: A biosensor system can comprise a sensor chip and a measurement device. The sensor chip comprises a capillary and electrodes disposed within the capillary. The height of the capillary is set to be less than the maximum value of the sum of the diffusion distance of an electron-transfer mediator and... Agent:

20120028283 - Analyte sensors having temperature independent membranes: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane structure with an analyte permeability that is substantially temperature independent. The devices also include a sensing layer disposed on a working electrode of in vivo analyte sensors, e.g., continuous... Agent: Abott Diabetes Care Inc.

20120028284 - Trapping compounds and method for identifying reactive metabolites: b

20120028285 - Clickable cross-linker: A clickable cross-linker compound provides an easily scanned reporter ion for effective and efficient cross-linking and identification of intermolecular and intramolecular interactions of proteins and peptides.... Agent:

20120028286 - Method for evaluating the breakdown of proteins, polypeptides and peptides: Provided is an assay for determining the protein, polypeptide, and peptides degradation of a sample. The assay for determining the protein, polypeptide, and peptides degradation of a sample includes contacting the sample with a non-fluorescent compound whereby the non-fluorescent compound reacts with free primary amine in the sample from degradation... Agent:

20120028287 - Crystal structure of aldehyde dehydrogenase and methods of use thereof: The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general... Agent:

20120028291 - Charged-balanced imaging agents: The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio.... Agent: Beth Israel Deaconess Medical Center, Inc.

20120028290 - Compositions and methods for labeling and imaging phospholipids: The present invention provides a method to label phospholipids in vivo based on the metabolic incorporation of an alkynyl- or azido-labeled metabolic precursor into phospholipids. The resulting phospholipids have alkynyl or azido moieties, which, upon reaction with a labeled azide or alkyne, respectively, form labeled compounds that can be visualized... Agent: President And Fellows Of Harvard College

20120028288 - Method for measuring cell motility and system therefor: The present invention is intended to provide a technique whereby quantitative data of cellular chemotactic activity can be obtained. Namely, it relates to a method of measuring cell motility whereby the motility state of cells is measured. Living cells are placed in an observation space (100) in such a state... Agent:

20120028289 - Method of identifying endogenous fluorescent biological markers for monitoring cells: The present application is related to methods for the identification of endogenous fluorescent biological markers that generate information on cell culture parameters. Because the techniques provided herein provide accurate results in a relatively short amount of time, the methods described herein can be used to identify numerous endogenous fluorescent biological... Agent:

20120028292 - Methods for diagnosing kidney damage associated with heart failure: Disclosed is a method for diagnosing kidney damage in a subject suffering from heart failure including the steps of a) determining the amounts of liver-type fatty acid binding protein (L-FABP) and kidney injury molecule 1 (KIM-1) and optionally a natriuretic peptide in a sample of a subject, b) forming the... Agent:

20120028293 - Mixing device and mixing method for mixing small amounts of liquid: The invention relates to a mixing method for mixing at least one small quantity of liquid, in which a quantity of liquid is applied, in a reaction region and at least one surface sound wave is reacted with the quantity of liquid. The invention relates further to a mixing device... Agent: Beckman Coulter, Inc.

20120028296 - Fecal sample collection and processing apparatus and method: A method for collecting and processing biological samples (e.g., fecal samples) is disclosed. The method may include obtaining a system comprising a container, a collector, and a lid. Using the collector, a user may collect a sample. The sample may be inserted within the container. The lid may be secured... Agent:

20120028294 - Home test kit for detecting fecal blood: A home test kit for detecting fecal blood includes a scoop device for collecting a fecal sample, a luminescent for mixing with the sample, a hollow container for containing the sample, water and the luminescent, or luminol during use of the kit. A base may be provided for supporting the... Agent: Life Fit Testing, LLC

20120028295 - Synergistic composition useful as microbiological growth medium for rapid screening of phosphate accumulating microorganisms: Screening isolates for phosphate accumulation by quantitative methods requires investment of time, labour and chemicals. There has been paucity of a medium and method for screening phosphate-accumulating microorganisms (PAOs) from the environment. Therefore, a new screening strategy is needed towards isolating effective PAOs in environments with diverse microbial populations and... Agent: Council Of Scientific And Industrial Research

20120028297 - Environmental sampling articles and methods: The present invention refers to articles for collecting samples from a surface, articles for microbiological analyses of said samples, and methods of use of said articles. The articles include sample collectors, sample housings with optional barrier layers, and sample-ready reagent strips comprising hydrophilic agents to grow and detect microorganisms. The... Agent: 3m Innovative Properties Company

20120028298 - System and method for automated tissue slide processing and data management: To simplify the process of preparing tissue specimens on slides, an advanced automated slide processing device is disclosed. The automated slide processing device comprises a robotic arm that both senses input and delivers output. The input sensing may include sensing radio frequency identifiers (RFIDs). The output includes arm movements, the... Agent:

20120028299 - Enzymatic hydrolysis of pretreated lignocellulose-containing material with dissolved air flotation sludge: A method for producing a fermentation product from a lignocellulose-containing material comprises pretreating the lignocellulose-containing material; introducing treated dissolved air flotation sludge to the pretreated lignocellulose-containing material; exposing the pretreated lignocellulose-containing material to a hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation product.... Agent: Novozymes North America, Inc.

20120028300 - Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof: The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation... Agent: Intrexon Corporation

20120028301 - Somatic hypermutation systems: The present application relates to somatic hypermutation (SHM) systems and synthetic genes. Synthetic genes can be designed using computer-based approaches to increase or decrease susceptibility of a polynucleotide to somatic hypermutation. Genes of interest are inserted into the vectors and subjected to activation-induced cytidine deaminase to induce somatic hypermutation. Proteins... Agent: Anaptysbio, Inc.

20120028304 - Antibodies with modified isoelectric points: The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo.... Agent: Xencor, Inc.

20120028302 - Production of oligoclonal mixtures of immunoglobulins in single cells: The present invention provides methods to produce mixtures of exogenous proteins in single cells. Preferably said exogenous proteins are heteromeric and multimeric proteins, such as immunoglobulins. The method enables the controlled expression of proteins, thereby allowing the correct formation and assembly of multimeric proteins, such as immunoglobulins.... Agent: Morphosys Ag

20120028303 - Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions: A method of engineering immunoglobulins which each have one or more amino acid modifications in at least one structural loop region of such immunoglobulins, where the modified loop region specifically binds to an epitope of an antigen to which an un-modified immunoglobulin does not significantly bind.... Agent: F-star Biotechnologische Forschungs-und Entwicklungsges.m.b.h

20120028305 - Solubilization and purification of a target protein fused to a mutant maltose-binding protein: Methods and compositions are provided that relate to a composition that includes a modified maltose-binding protein (MBP) which when fused to a protein results in an increase in binding affinity for maltodextrin compared with the wild type MBP fused to the protein, the modified MBP maintaining enhanced solubility, The modification... Agent: New England Biolabs, Inc.

20120028306 - Polypeptides with xylanase activity: Polypeptides with xylanase activity modified to increase bran solubilization and/or xylanase activity. The modification comprises modification of one or more amino acids in position 12 or 13 in combination with one or more further amino acid modifications in position 15, 34, 54, 77, 81, 82, 99, 104, 110, 113, 114,... Agent: Danisco A/s

20120028308 - Enzymatic production of an ethylenically unsaturated glycoside: l

20120028307 - Enzymatic production of an ethylenically unsaturated glycoside using polysaccharides:

20120028309 - Method for producing indole derivative: The present invention provides a method for in vitro producing an indole derivative in a one-pot reaction. The method for producing a rhamnosylated indolocarbazole compound includes the steps of transforming a plasmid carrying a gene encoding N-glycosyltransferase into a bacterial strain; expressing the gene encoding N-glycosyltransferase in the bacterial strain;... Agent: National Chiao Tung University

20120028311 - Cartridge with lysis chamber and droplet generator: Systems, including apparatus, methods, compositions, kits, and software, for preparing, reacting, detecting, and/or analyzing samples in droplet-based assay systems, among others. The disclosure emphasizes, but is not limited to, a disposable cartridge with lysis chamber and droplet chamber, particularly for use in droplet-based assays.... Agent: Quantallife, Inc.

20120028310 - Isothermal nucleic acid amplification methods and compositions: Methods and compositions are provided related to the amplification of target polynucleotide sequences as well as total RNA and total DNA amplification. In some embodiments, the methods and compositions also allow for the immobilization and capture of target polynucleotides with defined 3′ and or 5′ sequences to solid surfaces. The... Agent: Nugen

20120028312 - Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference: The present invention concerns methods and compositions involving RNase III and polypeptides containing RNase III domains to generate RNA capable of triggering RNA-mediated interference (RNAi) in a cell. In some embodiments, the RNase III is from a prokaryote. RNase III activity will cleave a double-stranded RNA molecule into short RNA... Agent: Life Technologies Corporation

20120028313 - Oligonucleotide linkers comprising a variable cohesive portion and method for the preparation of polynucleotide libraries by using said linkers: The present invention relates to a linker or population of linkers that include an oligonucleotide fixed portion and an oligonucleotide variable portion represented by formula (N)n, wherein N is A, C, G, T or U, or their derivatives, and n is an integer equal to or higher than 1. A... Agent: Riken

20120028314 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent:

20120028315 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent:

20120028316 - Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe: The present invention provides an enzymatic process for the preparation of (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)-5-morpholin-4-yl-pentane-1,5-dione by using a suitable enzyme or by the resolution of (R,S)-5-(4-Fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one by using an enzyme. The present invention also provides process for the preparation of Ezetimibe comprising the steps of a) protecting the... Agent:

20120028317 - Hydroxynitrile lyase: An improved hydroxynitrile lyase characterized by having a mutation of substitution of at least one amino acid residue in the amino acid sequence of a wild-type hydroxynitrile lyase with another amino acid and by its hydroxynitrile lyase activity per transformant being higher than the hydroxynitrile lyase activity per transformant into... Agent: Mitsubishi Rayon Co., Ltd.

20120028319 - Chlorella species containing exogenous genes: The invention provides methods of cultivating oil-bearing microbes using xylose alone or in combination with other depolymerized cellulosic material. Also provided are microorganisms comprising an exogenous gene encoding a polysaccharide degrading enzyme, such as a cellulase, a hemicellulase, a pectinase, or a driselase. Some methods of microbial fermentation are provided... Agent: Solazyme, Inc.

20120028318 - Fungal cutinase from magnaporthe grisea: Described are compositions and methods relating to a fungal cutinase cloned from Magnaporthe grisea, polynucleotides encoding the cutinase, and methods of use thereof. The compositions and methods have particular application in detergent cleaning compositions and synthesis reactions.... Agent: Danisco US Inc.

20120028320 - Preparation of adipic acid: The invention relates to a method for preparing adipic acid, comprising converting alpha-ketoglutaric acid (AKG) into alpha-ketoadipic acid (AKA), converting alpha-ketoadipic acid into alpha-ketopimelic acid (AKP), converting alpha-ketopimelic acid into 5-formylpentanoic acid (5-FVA), and converting 5-formylpentanoic acid into adipic acid, wherein at least one of these conversions is carried out... Agent: DsmIPAssets B.v.

20120028321 - High solids fermentation for synthesis of polyhydroxyalkanoates from gas substrates: Production of polyhydroxyalkanoates (PHAs) is performed by delivering substrates such as methane in gas phase during a high solids fermentation. Microorganisms are grown under balanced conditions, then gas phase substrates are delivered under unbalanced conditions to produce PHA granules inside the cells. The cells containing these granules are lysed and... Agent:

20120028324 - Engineered microorganisms capable of producing target compounds under anaerobic conditions: The present invention is generlly provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH... Agent: Gevo, Inc.

20120028322 - Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids: The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or... Agent: Gevo, Inc.

20120028323 - Yeast organism producing isobutanol at a high yield: The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described... Agent: Gevo, Inc.

20120028325 - Flow-through biological conversion of lignocellulosic biomass: The present invention is directed to a process for biologically converting carbohydrates from lignocellulosic biomass comprising the steps of: suspending lignocellulosic biomass in a flow-through reactor, passing a reaction solution into the reactor, wherein the solution is absorbed into the biomass substrate and at least a portion of the solution... Agent:

20120028326 - Method of carbon sequestration: The present invention relates to methods and apparatus for robust and long-term sequestration of carbon. In particular, the present invention relates to sequestration of carbon as carbonates, using coccolithophorid algae grown using land-based aquaculture. The invention also relates to improved methods of Ocean Thermal Energy Conversion (OTCE).... Agent:

20120028327 - Materials and methods for identifying and using yeast strains that metabolize pentose sugars in the presence of d-glucose: Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants of Saccharomyces cerevisiae that can grow on sugars other than D-glucose in the presence of amounts of 2-deoxy-glucose and or D-glucose that inhibit most strains of yeast from growing on sugars other than D-glucose. Selection... Agent:

20120028328 - Coated substrates and methods of preparing the same: Disclosed herein are coated articles and methods of preparing the same.... Agent: Ecology Coatings, Inc.

20120028331 - Enzymatic reaction reagent, enzymatic reaction reagent kit and method for storing liquid for enzymatic reaction: An enzymatic reaction reagent prepared by freezing a liquid for enzymatic reaction that is divided into a plurality of constituent liquids, wherein at least one of the constituent liquids contains an enzyme, each of the constituent liquids is frozen individually, and all of the constituent liquids are encased in a... Agent:

20120028329 - Optically transparent glass and glass-ceramic foams, method for production thereof and use thereof:

20120028330 - Polypeptide having activity of aminoacyl-trna synthetase and use thereof: A polypeptide according to the present invention includes: an altered polypeptide obtained by altering an ArgRS, a CysRS, a MetRS, a GlnRS, a GluRS, a LysRS, a TyrRS, or a TrpRS so that an unnatural amino acid is recognized; and an editing polypeptide derived from a PheRS, a LeuRS, an... Agent: Riken

20120028332 - Process for production of an enzyme product: The invention relates to a process for production of an enzyme product having a plurality of enzyme activities obtained by fermentation of an Aspergillus strain.... Agent: Danisco A/s

20120028333 - Use of enzymes to reduce aldehydes from aldehyde-containing products: The invention relates to the use of an enzyme preparation which catalyzes the degradation of formaldehyde for reducing the formaldehyde content in a formaldehyde-containing formulation. In a preferred embodiment, the enzyme preparation contains a formaldehyde dismutase from a Pseudomonas putida strain. Further, the invention refers to a process for reducing... Agent:

20120028334 - Polypeptides having arabinofuranosidase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having alpha-L-arabinofuranosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20120028335 - Anti-viral azide-containing compounds: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a human immunodeficiency virus with an... Agent: Life Technologies Corporation

20120028336 - Single recombination system and methods of use: The present invention is directed to a modified poxvirus vector that allows for the generation of recombinant poxviruses by a single recombination event. A modified poxvirus vector comprising at least one reporter gene located between two flanking sequences for homologous recombination is disclosed. Furthermore, a host cell comprising said vector... Agent: Emergent Product Development Germany Gmbh

20120028337 - Methods of and systems for dewatering algae and recycling water therefrom: A method of dewatering algae and recycling water therefrom is presented. A method of dewatering a wet algal cell culture includes removing liquid from an algal cell culture to obtain a wet algal biomass having a lower liquid content than the algal cell culture. At least a portion of the... Agent:

20120028338 - Mixotrophic algae for the production of algae biofuel feedstock on wastewater: The disclosure encompasses, among other aspects, mixed algal populations able to survive and proliferate on culture media that have a high proportion of an industry wastewater. In particular, at least one strain of an alga in the algal population proliferates mixotrophically. Embodiments further encompass methods of cultivating mixed populations of... Agent:

20120028339 - Methods of producing biofuels from an algal biomass: A method for producing biofuels is provided. A method of making biofuels includes dewatering substantially intact algal cells to make an algal biomass, extracting neutral lipids from the algal biomass, and esterifying the neutral lipids with a catalyst in the presence of an alcohol. The method also includes separating a... Agent: Heliae Development, LLC

20120028340 - Methods of producing biofuels from an algal biomass: A process for synthesis of 4S-phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3 oxazolidin 2-one comprising resolution of 4S-phenyl-3-[(5RS)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3 oxazolidin 2-one by selective esterification of 4S-phenyl-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3 oxazolidin 2-one using appropriate esterification reagent in an organic solvent in presence of Lipase enzyme at a temperature ranging from 0° to 100° C., and further isolation.... Agent:

20120028341 - Petroleum bioprocessing to prevent refinery corrosion: The present invention relates to the bioupgrading of crude oil is directed to a process for decreasing the acidity of an acidic crude oil, comprising contacting an acidic crude oil with a mixture nitrogen containing compounds selected from the group comprising ammonia, ammonia hydroxide, amines and the salts thereof, and... Agent:

20120028342 - Slip chip device and methods: A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where... Agent:

20120028343 - Sample processing apparatus: There is provided a sample processing apparatus capable of detecting the push-up type sample container including a recess on the outer side of the bottom portion of the container and performing an appropriate sample processing while alleviating the load of the user with a simple configuration.... Agent:

20120028344 - Immunodiagnostic test cards having indicating indicia: An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid in the manufacture and determining the usability of the cards... Agent: Ortho-clinical Diagnostics, Inc.

20120028345 - solid state fermentation (ssf) system: The present invention relates to a solid state fermentation system. The system comprises a fermenter module having plural port means for allowing inlet and outlet of substrate to be fermented and control module being operatively inter-engaged with said fermenter module in a manner so as to provide control of fermentation... Agent:

20120028346 - Microalgae photobioreactor: A bioreactor is provided for circulating a fluid medium. To reduce manufacturing and maintenance expenses, the bioreactor is formed from two sheets of transparent plastic. Structurally, each sheet has first and second edges extending in an axial direction between proximal and distal ends. To form the bioreactor, the sheets are... Agent:

20120028347 - Agent for suppressing replication of hiv and use thereof: (1) an antibody recognizing human CD4, which comprises, as the amino acid sequence of the variable region of a heavy chain thereof, the amino acid sequence shown in SEQ ID NO: 2 in the sequence listing, or an amino acid sequence having at least one type of mutation selected from... Agent: Tokai University Educational System

20120028348 - Multiple rna polymerase iii promoter expression constructs: Expression constructs comprising at least two different RNA polymerase III promoters, wherein each promoter is operably linked to a nucleic acid sequence encoding an RNA effector molecule, are disclosed herein. Further provided are expression constructs comprising multiple polymerase III promoters operably linked to sequences encoding short hairpin RNA molecules, which... Agent: Alnylam Pharmaceuticals, Inc.

20120028350 - Bone marrow targeting peptides: A peptide for targeting bone marrow consists of about 5 to about 25 amino acids and includes an amino acid sequence that targets the peptide to bone marrow.... Agent:

20120028349 - Sorting chamber: A sorting chamber (1) for sorting first particles (25) from second particles (26) comprising: an internal chamber (7), which is delimited by a base wall (2), a top wall (4), and a spacer (6), set between the base wall (2) and the top wall (4); an internal chamber (7), which... Agent: Silicon Biosystems S.p.a.

20120028351 - Generation and maintenance of stem cells: The present invention provides for the generation and maintenance of pluripotent cells by culturing the cells in the presence of an ALK5 inhibitor.... Agent: The Scripps Research Institute

20120028352 - Microcarriers for stem cell culture: We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50... Agent: Agency For Science, Technology And Research

20120028353 - Hepatic stellate cell precursors and methods of isolating same: The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1+, VCAM-1+, β3-integrin+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin,... Agent: University Of North Carolina At Chapel Hill

20120028354 - Systems and methods for making hepatocytes from extrahepatic somatic stem cells and use thereof: A method for preparing isolated hepatocytes is disclosed. The method comprises: a) culturing mesenchymal stem cells (MSCs) in a medium comprising hepatic growth factor (HGF) to cause the MSCs to differentiate toward hepatocytes, wherein the MSCs are isolated from bone marrow or umbilical cord blood; b) culturing cells from a)... Agent: National Yang-ming University

20120028355 - Culture medium for epithelial stem cells and organoids comprising said stem cells: The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising the epithelial stem cells, or adenoma cells, and culturing the cells or fragments in the presence of a Bone Morphogenetic Protein (BMP) inhibitor, a mitogenic growth factor, and a Wnt agonist when culturing epithelial stem... Agent: Koninklijke Nederlandse Akademie Van Wetenschappen

20120028356 - Transfection with micro explosion enacted by coated dry ice particles: Disclosed is a transfection method, which includes the steps of: (a) adhering the gene fragments to dry ice particles; (b) adding the dry ice particles into the medium/liquid that contains target cells; and (c) transporting the gene fragments into the target cells via the micro explosion/sublimation of the dry ice... Agent: National Yang Ming University

20120028357 - Aav vectors produced in insect cells: The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of the AAV VP1 capsid protein is a non-ATG, suboptimal initiation codon. The insect... Agent:

20120028358 - Method for increasing retroviral infectivity: The present invention is directed to methods for enhanced retroviral delivery of a nucleic acid to a target cell in vitro, ex vivo or in vivo, which involves increasing infectivity of a retrovirus carrying a transgene of interest to a target cell. In one particular aspect the invention relates to... Agent: University Of South Alabama

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