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Chemistry: molecular biology and microbiology January recently filed with US Patent Office 01/12

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
01/26/2012 > 122 patent applications in 59 patent subcategories. recently filed with US Patent Office

20120021401 - Disposable cartridge for automatic and continuous water quality monitoring: A disposable cartridge for use in assaying an analyte in an automated water quality monitoring analyzer comprising: (a) a platform; (b) array of containers for separately containing at least one reagent, a buffer and a so freeze dried preparation of luminescent bacteria, said containers being mounted on said platform; (c)... Agent: Check Light Ltd.

20120021402 - Biosensor apparatuses and methods thereof: A biosensor has one or more field effect transistors each comprising a source region and a drain region separated by a channel region and a gate positioned offset and spaced from the channel region. The biosensor also has one or more molecular probes coupled to at least one of the... Agent:

20120021403 - Human endogenous retrovirus with foamy-like properties and uses thereof: The invention relates to the discovery of a human endogenous retrovirus (HERV) family, Type I HERV-K (HML-2) which appear to be active in vitro and in vivo, infectious, and which have the have the salient features and properties of foamy retroviruses. Based on its natural replication in humans, and that... Agent:

20120021404 - Method for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine: The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed... Agent: Trovagene, Inc.

20120021406 - Method for monitoring a sterilization process: The disclosed invention relates to a method for monitoring a sterilization process. The method comprises: (A) exposing an article to be sterilized and a biological indicator to a sterilization medium during a sterilization process, the biological indicator comprising a cell with a plasma membrane; and (B) measuring the membrane potential... Agent:

20120021407 - Methods and devices for rapid urine concentration: The present invention provides a device for the concentration of one or more target analytes contained in a urine sample. The device comprises a tube comprising an upper portion defining an opening for receiving the urine sample and a lower tapered portion terminating in collection reservoir. The tube contains a... Agent: Norgen Biotek Corp.

20120021405 - Single chain antibody for the detection of noroviruses: The present invention concerns compositions and methods for detecting Norovirus or Norovirus particles. In particular, the present invention encompasses antibodies for detecting Norovirus or Norovirus particles, including, for example, monoclonal antibodies that have broad specificity of binding to various genogroups of norovirus.... Agent: Baylor College Of Medicine

20120021411 - Automated high-throughput seed sampler and methods of sampling, testing and bulking seeds: A seed sampling system includes a seed transport configured to hold multiple individual seeds together as a group and transport the multiple individual seeds together as the group, and to allow the multiple individual seeds to be oriented, substantially simultaneously, while the multiple individual seeds are being held in the... Agent: Monsanto Technology LLC

20120021409 - Common light chain mouse: A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making... Agent: Regeneron Pharmaceuticals, Inc.

20120021408 - Four-color dna sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.... Agent: The Trustees Of Columbia University In The City Of New York

20120021410 - Triggered molecular geometry based bioimaging probes: The present embodiments relate to engineering imaging probes based on “triggered molecular geometry.” Upon detection of a molecular signal, nucleic acid hairpin monomers assemble an imageable molecular shape with prescribed geometry. In some embodiments the prescribed shape can be imaged directly. In some embodiments, the prescribed shape can serve as... Agent:

20120021416 - Biolayer interferometry measurement of biological targets: Disclosed are methods and compositions for the ultrasensitive detection of oligonucleotides, proteins, protein complexes, biomolecules, and infectious agents using a peroxidase driven deposition of substrates onto interferometry capable biosensors, coupled to the specific recognition of the target molecules. More specifically, methods are disclosed to specifically immobilize biological target molecules onto... Agent: Saint Louis University

20120021412 - Compositions and methods for detecting pathogen specific nucleic acids in urine: The invention is based upon the discovery that small nucleic acids from non-viral pathogens are able to cross the kidney and are present in urine of a subject when the subject is infected with the non-viral pathogen. These transrenal DNAs are especially prevalent at smaller sizes under about 300 bp.... Agent:

20120021414 - Diagnostic markers of immunosenescence and methods of use thereof: Embodiments of the present invention provide diagnostic markers of immunosenescence and methods of identifying individuals with impaired immune function based on a combination of such markers obtained from various analyses, primarily from blood, testing immune function including the analysis of immune cell subset frequencies, gene expression, cytokine and chemokine levels,... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20120021417 - Dopaminergic neuron proliferative progenitor cell marker nato3: The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can... Agent: Eisai R&d Management Co., Ltd.

20120021413 - Method for detecting mutation in exon 12 of jak2 gene, and nucleic acid probe and kit therefor: e

20120021415 - Methods for determining response to neoadjuvant therapy and survival using microrna-10b: The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression and optionally the presence of a protein cancer cell marker in biological samples such as formalin-fixed paraffin-embedded specimens using in situ hybridization and optionally an... Agent: Trustees Of Dartmouth College

20120021419 - Analyzing system, analyzing apparatus, container, analyzing method, program, and recording medium: An analyzing system that enables further expansion of analysis items and automation of analysis. In the analyzing system for performing an analysis using container 1 and an analyzing apparatus, container 1 is a dedicated container previously containing a reagent for a specific analysis item or an expansion container to which... Agent: Arkray, Inc.

20120021421 - Bacterial dna as markers of cardiovascular and/or metabolic disease: The present invention relates to an in vitro method for predicting and/or diagnosing a cardiovascular and/or metabolic disease in a subject, which method comprises determining the concentration of bacterial DNA in a biological sample of said subject, together with degenerated primers for predicting and/or diagnosing a cardiovascular and/or metabolic disease... Agent:

20120021429 - Compositions, products, methods and systems to monitor water and other ecosystems: Disclosed are compositions, products, methods and systems for monitoring ecosystems, such as bodies of water, for a parameter of the ecosystems, such as the presence or absence of mercury. In one embodiment, the product may include a plurality of oligonucleotides immobilized at known locations on a substrate as an array,... Agent:

20120021423 - Controls and calibrators for tests of nucleic acid amplification performed in droplets: System, including methods and apparatus, for performing droplet-based tests of nucleic acid amplification that are controlled and/or calibrated using signals detected from droplets.... Agent: Quantalife, Inc.

20120021424 - Device and method for thermal cycling: A thermal cycling device for performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray. The thermal cycling device includes a sample block assembly, an optical detection system, and a sample well tray holder configured to hold the sample well tray. The sample block... Agent: Life Technologies Corporation

20120021418 - Gene that imparts oxygen resistance and application thereof: The oxygen-resistance-imparting gene encoding a protein selected from among the following proteins (a) to (c): (a) a protein having the amino acid sequence of SEQ ID NO: 2 or 6; (b) a protein which has an amino acid sequence equivalent to the amino acid sequence of (a), except that one... Agent: Kabushiki Kaisha Yakult Honsha

20120021428 - Method for diagnosis of cancer and monitoring of cancer treatments: The present invention relates to a method for cancer diagnosis and for monitoring cancer treatments based on the analysis of the DNA fragmentation pattern of repetitive elements (preferably LINED or multi copy genes (preferably U1 RNA) identified in body fluid samples isolated from cancer patients.... Agent:

20120021426 - Method of detecting target substance: The method of detecting a target substance of the present invention includes a step of providing a probe 4 in which an aptamer-bindable substance 1 and a labeling substance 2 are each bound to a linker 14 that is immobilizable to a support 5 and an aptamer 6 is bound... Agent: Nec Corporation

20120021422 - Methods for processing samples in a closed container: A system and method for automated processing of nucleic acids and other samples includes a disposable container comprising a tray and a flexible barrier. The barrier is configured to seal with a top edge of the tray, providing a closed, aseptic work area within the sealed tray. A pipette head... Agent:

20120021427 - Methods for rapid forensic dna analysis: The present invention provides methods and primer pairs for rapid, high-resolution forensic analysis of DNA and STR-typing by using amplification and mass spectrometry, determining the molecular masses and calculating base compositions of amplification products and comparing the molecular masses with the molecular masses of theoretical amplicons indexed in a database.... Agent: Ibis Bioscience, Inc

20120021425 - Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind... Agent: The Regents Of The University Of California

20120021420 - Synthetic sirna detection method: A method for accurately and easily detecting a synthetic siRNA, for example, a siRNA in which the 3′ end is DNA, and a kit used for the method are provided. The present invention relates to a method for detecting a siRNA in which the 3′ end is DNA, comprising: (a)... Agent: Takara Bio Inc.

20120021431 - Diagnostic methods using bnp: The present invention provides a new method and kit for determining the overload of atrium or ventricle in a subject comprising at least a step of measuring levels of proBNP-108 in a sample from the subject. The disclosed methods and kits are useful, for example, in the diagnosis, prevention and/or... Agent: Shionogi & Co., Ltd.

20120021430 - Functional lipid constructs: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications,... Agent:

20120021434 - Method for treating b cell regulated autoimmune disorders: The invention relates to a method for treating B-cell regulated autoimmune disorders using compounds that modulate the activity of c-Rel.... Agent: Synta Pharmaceuticals Corp.

20120021432 - Phosphorylated nf45 biomarkers, antibodies and methods of using same: The present invention relates to isolated phosphorylated NF45 peptides and isolated phosphorylation site-specific antibody or antigen-binding portion thereof that specifically binds a phosphorylated NF45 protein. The present invention also relates to methods of utilizing these antibodies to determine the therapeutic efficacy of a candidate compound and methods for screening for... Agent: Arqule, Inc.

20120021433 - Reducing optical interference in a fluidic device: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces... Agent:

20120021440 - Methods for testing ligand binding to g protein-coupled receptors: The present invention relates to methods for testing for the binding of a ligand to a G Protein-Coupled Receptor. In particular, the methods of the invention are useful in high throughput screening for ligands which bind to G Protein-Coupled Receptors.... Agent: Ge Healthcare Uk Limited

20120021435 - Detection of living, circulating, or disseminated cells or cell constituents in blood or bone marrow following filtration of blood: A method is disclosed for detecting circulating cells in a body fluid sample. In at least one embodiment, the method includes: filtering the body fluid sample through a porous membrane; transferring the porous membrane with the cells located thereon as filter residue to a cell culture vessel, wherein one surface... Agent: Siemens Aktiengesellschaft

20120021436 - Crystal structure of human alpha-n-acetylglucosaminidase: The present invention provides the three-dimensional structure of human α-N-acetylglucosaminidase (NAGLU) protein. This crystallographic information is useful in the identification and development of novel binding compounds of NAGLU, NAGLU mutants, for example, those associated with Sanfilippo syndrome type B (mucopolysaccharidosis III B (MPS III-B)), and other NAGLU family members (family... Agent: Shire Human Genetic Therapies, Inc.

20120021438 - Method of detecting target, method of suppressing increase in background and detection apparatus: A first target-binding substance that is immobilized at a carrier and is capable of binding to a target and a second target-binding substance that supports a labeling substance and is capable of binding to the target are used. By reacting a sample, the first target-binding substance, and the second target-binding... Agent: Arkray, Inc.

20120021439 - Serial multiple antigen colocalization in paraffin-embedded tissue: The present invention provides a novel method called Sequential IMmunoPeroxidase Labeling and Erasing (SIMPLE) that enables the simultaneous visualization of at least five markers within a single tissue section. Utilizing the alcohol-soluble peroxidase substrate 3-amino-9-ethylcarbazole (AEC), combined with a rapid non-destructive method for antibody-antigen dissociation, the present application discloses the... Agent: University Of Virginia Patent Foundation

20120021437 - Tetranor-pgdm/pgjm specific immunogens, antibodies, tracers, assay kits and methods for making same: Tetranor-PGDM/tetranor-PGJM-specific antibodies, immunogens used to generate them, the processes of their manufacture, and their uses in assay kits for detecting and quantifying tetranor-PGDM and tetranor-PGJM in biological fluids for determining biosynthesis of PGD2 in a subject or patient.... Agent: Cayman Chemical Company, Incorporated

20120021443 - Directional surface plasmon coupled fluorescence and chemiluminescence from thin films of nickel, iron or palladium and uses thereof: Nickel, iron and palladium thin films thermally evaporated onto glass supports are used to demonstrate surface plasmon coupled fluorescence (SPCF) and surface plasmon couple chemiluminescence (SPCC) over a broad wavelength range (400-800 nm) for potential assays or other detection systems. Nickel, iron and palladium thin films used in SPCF and... Agent:

20120021441 - In-process control in a method for producing epo: c

20120021442 - Markers for detection of complications resulting from in utero encounters: Described herein are biomarkers, such as protein biomarkers, which are diagnostic of and predictive for complications that result from an in utero encounter, such as an infection by the fetus, that can lead to premature birth (PTB). The biomarkers can be used to identify fetuses and newborns at risk for... Agent: Yale University

20120021444 - Method for diagnosis of cystic fibrosis using kl-6 levels: The present invention provides a method for diagnosis of cystic fibrosis, the method comprising: measuring an amount of KL-6 in a sample of body fluid from a subject, and determining, based on the amount of KL-6 measured, the degree of presence of cystic fibrosis in the subject.... Agent: Eidia Co., Ltd.

20120021445 - Pluripotent stem cells for drug induced myopathy and malignant hyperthermia: The present invention relates to methods of identifying, collecting and isolating pluripotent stem cells, and compositions of purified stem cells for the diagnosis of susceptibility to drug induced myopathy (DIM) and malignant hyperthermia (MH). Specifically, the present invention provides methods of producing skeletal muscle myocytes from patient-specific stem cells, and... Agent:

20120021446 - Evaluation peptide for use in quantification of protein using mass spectrometer, artificial standard protein, and method for quantifying protein: Disclosed is an evaluation peptide for evaluating the efficiency of a pretreatment in the quantification of a protein using a mass spectrometer, having high reliability and high general versatility. Also disclosed is an artificial standard protein comprising the evaluation peptide. Further disclosed is a method for quantifying a protein utilizing... Agent: Tohoku University

20120021447 - Analytical rotors and methods for analysis of biological fluids: Devices for generating discrete flow of liquids in response to a driving force, for example centrifugal microfluidic devices for generating discrete flow in response to a constant driving force. The device includes a supply structure for supplying liquid at an inflow rate to a discretization structure in response to a... Agent: Biosurfit, S.a.

20120021452 - Belt agitation system for culture bottles: A specimen culture container agitation assembly includes an endless belt having a multitude of container-receiving clips attached thereto, each of which is adapted for retaining a specimen culture container to the belt. The belt is oriented vertically. The assembly further includes upper and lower pulleys over which the belt is... Agent: Biomerieux, Inc.

20120021449 - Device for automatically analyzing microorganisms and method for automatically analyzing microorganisms: After culturing blood, a culture liquid determined as positive is transplanted into a plate medium and a bacterial cell suspension that is directly usable for identifying and testing antibiotics-sensitivity is prepared without forming colonies. Provided are a device for automatically analyzing microorganisms and a method therefor whereby blood culture and... Agent:

20120021448 - Method for evaluating state of cells: Provided are a novel marker of the state of cells and the differentiation level of the same which is usable as a substitute for a gene or a protein; a means for quantitatively understanding this marker; and a means for understanding the state of specific cells and the differentiation level... Agent:

20120021450 - Methods for magnetic resonance imaging: In certain aspects the present invention provides methods and compositions related to contrast agents for magnetic resonance imaging. In certain variations, contrast agents provided herein are generated in situ via genetic instructions and become potent upon sequestering available metal atoms. Exemplary contrast agents include metal-binding proteins.... Agent: Carnegie Mellon University

20120021451 - Sample analysis apparatus and sample analysis method: An analysis apparatus includes a plurality of separation channels, a detector, and a control unit. In each separation channel, a particular component contained in a sample is separated from other components. The detector detects the separated particular component. The control unit controls an analysis step and a preprocessing step. The... Agent: Arkray, Inc.

20120021455 - Detector arrangement for blood culture bottles with colorimetric sensors: A detector arrangement for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating... Agent: Biomerieux, Inc.

20120021453 - Label-free cell sorting using near infrared emission: Disclosed are methods and systems for identifying and sorting cells based on a near-infrared emission pattern of the cell in response to excitation at 630±nm. The NIR emission pattern can be used for monitoring and sorting of cells in a label-free manner, and thus provides a positive method for selecting... Agent: University Of Calcutta

20120021456 - Method and apparatus for detecting the presence of anisotropic crystals and hemozoin producing parasites in liquid blood: An apparatus and method for detecting the presence of anisotropic crystals within a biologic fluid sample is provided. The method includes the steps of: a) disposing the sample within a sample chamber in a sample layer having a height riot greater than about fifteen microns (15μ); b) disposing the sample... Agent: Abbott Point Of Care, Inc.

20120021454 - Rapid fret-based diagnosis of bacterial pathogens: The invention comprises a substrate for detection of micro-organisms, wherein said substrate comprises a set of molecular markers linked, optionally with linker molecules or moeieties, to a di-, or tripeptide consisting of amino acids X1 and X2, or X1, X2 and X3, in which one of them, for example X1,... Agent:

20120021457 - Protein concentrates and isolates, and processes for the production thereof from macroalgae and/or microalgae: Protein concentrates and protein isolates, in addition to processes for the production of protein concentrates and protein isolates, are disclosed. In particular, the disclosure relates to the removal of fiber from macroalgae and/or microalgae using low g-force centrifugation.... Agent:

20120021458 - Thermotolerant transglutaminase originating in actinomyces: The present invention provides transglutaminases with improved heat resistance. Specifically, the present invention provides mutant transglutaminase proteins with improved heat resistance as obtained by introducing appropriate mutations into transglutaminases, which results in the incorporation of a disulfide bond.... Agent:

20120021459 - Feed media: The invention provides stable feed media containing pyruvate and methods for stabilizing feed media by adding pyruvate. The invention further provides methods for producing proteins using such media and proteins produced through the use of such methods.... Agent: Amgen Inc.

20120021461 - Isothermal strand displacement amplification: A method for isothermal DNA amplification comprising: providing to the DNA to be amplified an amplification mix comprising a first primer at least partially complementary to a region of DNA and containing Xanthosine, a second primer at least partially complementary to a region of DNA and containing Xanthosine, a DNA... Agent: Human Genetic Signatures Pty. Ltd.

20120021460 - Materials and methods for isothermal nucleic acid amplification: A method for isothermal amplification of a target nucleic acid sequence is disclosed. The target nucleic acid is amplified by an enzyme with helicase activity and an enzyme with reverse transcriptase activity and DNA-dependant DNA polymerase activity. Also disclosed is a kit for isothermal amplification of a target nucleic acid... Agent: Qiagen Gaithersburg Inc.

20120021463 - Method and apparatus for amplification of nucleic acid sequences by using thermal convection: The present invention provides a nucleic acid sequence amplification method and apparatuses thereof that are simple in the design and easy to miniaturize and integrate into complex apparatuses, with capability of using DNA polymerases that are not thermostable. In the present invention, a plurality of heat sources are combined to... Agent: Ahram Biosystems, Inc.

20120021462 - Recombinase polymerase amplification: This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of the bacterial RecA and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods has the advantage of... Agent:

20120021464 - Thermostable reverse transcriptases and uses thereof: The present invention is in the fields of molecular and cellular biology. The invention is generally related to reverse transcriptase enzymes and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to reverse transcriptase enzymes which have been mutated or modified to... Agent: Life Technologies Corporation

20120021465 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent:

20120021466 - Microorganisms of corynebacterium with improved 5'-inosinic acid productivity, and method for producing nucleic acids using same: The present invention relates to a microorganisms of the genus Corynebacterium producing 5′-inosinic acid, in which the expression of genes encoding purine biosynthesis related enzymes is increased higher than the intrinsic expression, and to a method for producing 5′-inosinic acid, comprising culturing the microorganisms of the genus Corynebacterium with improved... Agent: Cj Cheiljedang Corporation

20120021467 - Method of producing xylitol and arabinose at same time from hemicellulose hydrolysates: The present invention relates to a method of producing xylitol and arabinose at same time from hemicellulose hydrolysates, material rich in xylan is hydrolyzed by acid or enzymes to obtain hydrolysate mostly containing xylose and arabinose, then inoculated in Issatchenkia orientalis S-7 and/or Issatchenkia occidentalis LJ-3 to eliminate the inhibitor... Agent: Thomson Biotech (xiamen) Pte. Ltd.

20120021468 - Production of l-ribose and other rare sugars: The invention provides methods and compositions for the production of L-ribitol and other rare sugars using a mannitol-1-dehydrogenase or a polyol-1-dehydrogenase.... Agent: Zuchem, Inc.

20120021469 - Amidases and methods of their use: The disclosure relates to engineered amidase polypeptides and processes of using the polypeptides for chiral resolution of amino acid amide compounds. The disclosure further relates to the polynucleotides that encode the engineered amidase polypeptides and related vectors, host cells, and methods for making the engineered amidase polypeptides.... Agent: Codexis, Inc.

20120021470 - Chimeric pufa polyketide synthase systems and uses thereof: Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids and proteins encoding such chimeric PUFA PKS proteins and systems, genetically modified organisms comprising such chimeric PUFA PKS... Agent: Martek Biosciences Corporation

20120021471 - Bioabsorbable polymer containing 2-hydroxyacid monomers: Genetically engineered organisms for production of PHA copolymers containing 2-hydroxyacid monomers and the methods of making and using thereof have been developed. The copolymers containing 2-hydroxyacid monomers can be synthesized via biosynthesis by the action of a PHA polymerase in a living cell. By changing the genetic background of the... Agent: Metabolix, Inc.

20120021472 - Method for the production of glutaconate: The present invention relates to a novel method for the biocatalytic production of unsaturated dicarboxylic acids by cultivating a recombinant microorganism co-expressing a glutaconate CoA-transferase and a 2-hydroxyglutaryl-CoA dehydratase system. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such... Agent: Basf Se

20120021474 - Biological methods for preparing adipic acid: The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.... Agent: Verdezyne, Inc.

20120021473 - Processes for producing carboxylic acids from fermentation broths containing their ammonium salts: Processes for making SA from either a clarified DAS-containing fermentation broth or a clarified MAS-containing fermentation broth that include distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that comprises water and ammonia, and a liquid bottoms that... Agent: Bioamber S.a.s.

20120021475 - Method for producing (+)-zizaene: A method of producing (+)-zizaene by contacting at least one polypeptide with farnesyl pyrophosphate (FPP) in vitro or in vivo to produce (+)-zizaene, a compound which can be used as precursor for diverse compounds useful in the fields of perfumery and flavoring. An amino acid sequence of a polypeptide useful... Agent: Firmenich Sa

20120021477 - Method for the fixation of co2 and for treating organic waste by coupling an anaerobic digestion system and a phytoplankton microorganism production system: The invention relates to a CO2 fixation and organic waste processing method, wherein microorganisms (105) from a phytoplanktonic culture and organic waste (104) are processed inside a hydrolysis reactor (101); at least part of a liquid effluent (109) exiting the hydrolysis reactor is processed inside a methanation reactor (102); a... Agent:

20120021478 - Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene: The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene.... Agent:

20120021476 - Trace element solution for biogas methods: The invention relates to a trace element solution for the supplementing of nutrients for an anaerobic fermentation, in particular a biogas process, comprising at least one trace element and at least two complexing agents. Complexing agents are used which (1) are able to transport the trace elements in complexed form... Agent: Agraferm Technologies Ag

20120021479 - Systems of hydrogen production in bacteria: This invention relates to engineered bacterial systems such as engineered cyanobacterial systems and to methods of using these bacterial systems to generate hydrogen.... Agent: President And Fellows Of Harvard College

20120021480 - Use of enzymes having silicase activity: The present invention relates to the use of polypeptides having silicase activity for the modification or synthesis of silica, silicones and other silicium (IV) compounds. The present invention also relates to the use of polypeptides having silicase activity for the modification of glass, sand, asbestos, computer chips, glass wool, fiber... Agent: Novozymes A/s

20120021481 - Electromechanical lysing of algae cells: Methods and electroporation devices for electrical treatment of algal cell cultures for release of lipids and proteins are described herein. The method of the present invention exploits the differences in electrical time constants for the media inside the cell and outside the cell to produce a net force to cause... Agent: Board Of Regents, The University Of Texas System

20120021482 - Methods for isolating very small embryonic-like (vsel) stem cells: The presently disclosed subject matter provides methods of isolating populations of stem cells that from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject.... Agent:

20120021483 - Method for producing lipase powder compositions: The present invention provides a method for producing a ground product of a lipase powder composition comprising an immobilized lipase in which a lipase derived from Thermomyces sp. is immobilized to a silica carrier and a hydrophilic powder other than a silica carrier, the method comprising the steps of wetting... Agent: The Nisshin Ollio Group, Ltd.

20120021484 - Recombinant fcrn and variants thereof for purification of fc-containing fusion proteins: The invention is directed to methods of purifying Fc-containing molecules using a soluble neonatal Fc receptor (sFcRn). Native FcRn binds Fc-containing proteins at or below about pH 6.5 and releases them at or above about pH 7 and provides a much milder approach for capturing and purifying Fc-containing proteins, in... Agent: Biogen Idec Ma Inc.

20120021486 - Enzyme-based nanoscale decontaminating composites: The invention relates to decontaminating composites, and methods, compositions, and kits comprising the same. In some aspects, the invention relates to a decontaminating composite, comprising a perhydrolase associated with a carbon nanotube, that is useful for producing peracids.... Agent:

20120021485 - Hybrid alpha-amylases: Hybrid alpha-amylases are provided that share a conserved 3D structure in whole or in part with a wild-type Termamyl-like ?-amylase, e.g., a Bacillus amylase. In the hybrid, an N terminal portion of a Termamyl-like ?-amylase is replaced with sequences from an archae ? amylase. The sequence similarity between the two... Agent: Danisco US Inc.

20120021487 - Method of treating gaucher disease: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.... Agent: The Hospital For Sick Children

20120021488 - Thermotolerant non-k12 escherichia coli phytase and its production: This invention relates to cloning and sequencing of thermotolerant phytase gene from Non-K12 Escherichia coli strain, ATCC 9637, phytase gene expression in Escherichia coli expression system, codon usage optimized and expression in Pichia pastoris, Pichia methanolica and Kluyeromyces lactis. The high level yield and thermotolerant enzyme was produced from fermentation... Agent: Fujian Fuda Biotech Co. Ltd.

20120021489 - Microbial enzymes as detergent additives: Provided in part herein are compositions that include isolated microbial enzymes, such as amylases, lipases, and proteases that are useful as detergent additives. Also provided are methods of isolating amylases, lipases, and proteases from microbes, as well as methods of using these enzymes as detergent additives, and for stain removal.... Agent:

20120021490 - Glucanases, nucleic acids encoding them and methods for making and using them: The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-D-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-D-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl... Agent: Verenium Corporation

20120021491 - Identification of antigen or ligand-specific binding proteins: The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse... Agent: 4-antibody Ag

20120021492 - Cultivation and dispensing of bacteria: An apparatus 100 for cultivating bacteria, comprising a conduit 101 having an upstream and a downstream section and the downstream section of the conduit 101 comprising first Venturi eductor means 111 with at least two inlet ports 117, 118 wherein one of said inlet ports 117 is in fluid communication... Agent: Delaware Capital Formation, Inc.

20120021494 - Enhanced photosynthesis and photocatalysis water treatment/biomass growth process: A process utilizing enhanced photosynthesis and photocatalysis to purify water and/or utilize CO2 on a large scale by growing biomass in reduced time and space in a closed, continuous-flow system. Added CO2 and balanced nutrients combine with light to increase the growth rate of autotrophic microalgae which require CO2 for... Agent: Krebs & Sisier L.p.

20120021495 - Generation of materials with enhanced hydrogen content from anaerobic microbial consortia including desulfuromonas or clostridia: An isolated microbial consortia is described. The consortia may include a first-bite microbial consortium that converts a starting hydrocarbon that is a complex hydrocarbon into two or more first-bite metabolic products. The consortia may also include a downstream microbial consortium that converts a starting hydrocarbon metabolic product into a downstream... Agent: Luca Technologies, LLC

20120021493 - Organic biofilm substrata as a microbial inoculum delivery vehicle for bioaugmentation of persistent organic pollutants in contaminated sediments and soils: A system and methods for removal of persistent organic pollutants (POPs) from an environment, where the system includes an inert and organic biofilm substrata as biofilm media for dual use: 1) inoculation of microorganisms to degrade POPs and 2) accumulation of POPs on the substrata, effective in maintaining bioavailable concentrations... Agent: University Of Maryland Baltimore County

20120021497 - Hydrodynamic extraction of oils from photosynthetic cultures: The presently described invention relates to the method of extraction of oils from photosynthetic cultures using hydrodynamic cavitation technology for the production of biofuels or other products. This method is referred to herein as Hydrodynamic extraction.... Agent:

20120021496 - Method for circulatory cultivating photosynthetic microalgae: A circulatory photobioreactor is provided. The circulatory photobioreactor comprises a first cultivating part, a second cultivating part and a pump part connecting the first cultivating part and the second cultivating part. The first cultivating part comprises a culture tank in which culture media are supplied and a first light source... Agent: Kairos Global Co., Ltd.

20120021498 - Photosynthetic reactor for cultivating microorganisms, and method for cultivating microorganisms: c

20120021499 - Method for removing pollutants in pollutants-contaminated soil: A method for removing pollutants in pollutants-contaminated soil is disclosed. The method includes following steps. A biodiversity system with microbial biodiversity characterization is used to induce growth and reproduce of at least one dominant synergistic flora for petroleum degradation. Most of the petroleum in the soil can be degraded when... Agent: Chi-tsan Lin

20120021500 - Biogas producing system: The present invention relates to a method for producing biogas by anaerobic digestion of organic matter. The method comprises: feeding organic matter suitable for biogas production to a first tank reactor 41, and in the first tank reactor, contacting the organic matter with biogas producing microorganisms for digestion under anaerobic... Agent:

20120021501 - Cell separation method and apparatus: Disclosed herein are apparatus and methods for isolating a fraction of interest from a physiological fluid sample. A sample holder for isolating a fraction of interest from a physiological fluid sample includes a flexible compartment and a rigid exoskeleton that supports the flexible compartment. The flexible compartment may have at... Agent: Ecw Therapeutics, Inc.

20120021502 - Sensor for fast detection of e-coli: A method of fabricating biochip sensor comprising providing a precursor; depositing the precursor on a substrate to form a coating; and rapid melting/quenching treatment of the coating with an energy source to form micro/nanotextured surface with enhanced reflectance for fast chemiluminescence response of E-Coli bacteria.... Agent: Mridangam Research Intellectual Property Trust

20120021503 - Biomass hydrothermal decomposition apparatus, temperature control method thereof, and organic raw material production system using biomass material: A biomass hydrothermal decomposition apparatus that feeds a solid biomass material 11 from one side of an apparatus body 42, feeds hot water 15 from the other side, to hydrothermally decompose the biomass material 11 while bringing the biomass material 11 into counter contact with the hot water 15, dissolves... Agent: Mitsubishi Heavy Industries, Ltd.

20120021504 - Aerated composter and waste collection bin: An aerated compost and waste collection bin is disclosed. The bin includes a body portion having a bottom, at least one sidewall from the bottom, and an open top forming a container. A perforated tube extends upwards from the bottom of the body portion. At least one lateral vent tube... Agent:

20120021505 - Circulatory photobioreactor: A circulatory photobioreactor is provided. The circulatory photobioreactor comprises a first cultivating part, a second cultivating part and a pump part connecting the first cultivating part and the second cultivating part. The first cultivating part comprises a culture tank in which culture media are supplied and a first light source... Agent: Kairos Global Co., Ltd.

20120021506 - Regulatory sequences for expressing gene products in plant reproductive tissue: Expression cassettes causing specific regulatory control of transgene expression in plants, wherein the expression cassettes include regulatory sequences from the MADS gene family for expression of recombinant gene products in the reproductive tissue of plants for the purpose of generating abiotic stress tolerant plants.... Agent: Syngenta Participations Ag

20120021507 - Bioreactor and uses thereof: Disclosed are bioreactor systems and methods to transfer a gaseous composition into a liquid composition in a closed environment. Also disclosed are bioreactor systems and methods for high-density culture of microorganisms and stably culture of activated sludge.... Agent: Hangzhou Jiuhua Qingbo

20120021508 - Method and device for identification of nucleated red blood cells from a maternal blood sample: A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal... Agent:

20120021509 - Isolating method for umbilical cord blood-derived pluripotent stem cells expressing znf281: The present invention relates to a method for isolating pluripotent/multipotent stem cells derived from umbilical cord blood, characterized by culturing monocytes isolated from umbilical cord blood in a culture vessel containing fibronectin and then harvesting stem cells from the culture, the umbilical cord blood-derived pluripotent/multipotent stem cells isolated thereby; and... Agent: Snu R&db Foundation

20120021510 - Method for improved single cell cloning: The present invention relates to methods for the cultivation of a population of cells in a serum free cell culture medium, wherein the population of cells has a cell concentration of less than 100 cells/ml, wherein a serum free cell culture medium containing recombinant albumin and recombinant transferrin is used.... Agent: Cellca Gmbh

20120021512 - Interleukin-1 alpha antibodies and methods of use: Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.... Agent: Xbiotech, Inc.

20120021511 - Preprimitive streak and mesendoderm cells: This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.... Agent:

20120021513 - Small molecules supporting pluripotent cell growth and methods thereof: The present invention relates to compositions and methods for maintaining undifferentiated pluripotent stem cell cultures.... Agent: Viacyte, Inc.

20120021514 - Heterogeneous polymeric micelles for intracellular delivery: Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.... Agent: University Of Washington

20120021516 - Novel structurally designed shrnas: Provided is an improved design of shRNA based on structural mimics of miR-451 precursors. These miR-451 shRNA mimics are channeled through a novel small RNA biogenesis pathway, require AGO2 catalysis and are processed by Drosha but are independent of DICER processing. This miRNA pathway feeds active elements only into Ago2... Agent:

20120021515 - Oligomeric compounds and methods: The present invention provides oligomeric compounds and uses thereof. In certain embodiments, such oligomeric compounds are useful as antisense compounds. Certain such antisense compounds are useful as RNase H antisense compounds, as RNAi compounds, and/or as modulators of splicing.... Agent:

20120021517 - Bacterial mediated delivery of nuclear protein into pluripotent and differentiated cells: A modified P. aeruginosa type III secretion system has been developed that efficiently delivers selected proteins into a host cell. In one example, a functional nuclear Cre Recombinase is injected into embryonic stem (ES) cells and can be used to induce pluripotent stem (iPS) cells. This method of in vitro... Agent: University Of Florida Research Foundation, Inc.

20120021519 - Efficient induction of pluripotent stem cells using small molecule compounds: The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-β-antibody to produce a reprogrammed cell (e.g.... Agent: Presidents And Fellows Of Harvard College

20120021518 - Growth factor homolog zvegf4: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the... Agent: Zymogenetics, Inc.

20120021520 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent:

20120021521 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent:

20120021522 - Method for the evolutionary design of biochemical reaction networks: The present invention relates to methods for achieving an optimal function of a biochemical reaction network. The methods can be performed in silico using a reconstruction of a biochemical reaction network of a cell and iterative optimization procedures. The methods can further include laboratory culturing steps to confirm and possibly... Agent: The Regents Of The University Of California

  
01/19/2012 > 98 patent applications in 54 patent subcategories. recently filed with US Patent Office

20120015343 - Methods for increasing isolation yields of cellular products: Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a donor tissue having desired cells and undesired cells, perfusing the donor tissue with a perfusion solution, developing edema during perfusion of the donor tissue to form... Agent: Lifeline Scientific, Inc.

20120015348 - Compositions and methods for detection of hepatitis a virus nucleic acid: Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences are disclosed.... Agent: Gen-probe Incorporated

20120015349 - Compositions for use in identification of papillomavirus: The present invention relates generally to identification of HPV, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent: Ibis Biosciences, Inc.

20120015345 - Identification of oligonucleotides for the capture, detection and quantitation of west nile virus: West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes.... Agent: Novartis Vaccines And Diagnostics, Inc.

20120015346 - Influenza virus detection and diagnosis: The invention discloses compositions comprising nucleic acid(s) for rapid detection, identification, differentiation, and/or diagnosis of certain Influenza virus A subtypes, e.g., H1N1, H3N2 and A(2009 H1N1)pdm, and methods of use thereof, e.g., Short-run RT-PCR, including an RT-PCR assay kit, comprising the disclosed composition(s).... Agent: New York Medical College

20120015350 - Lateral flow strip and uses thereof: The present invention relates to lateral flow strip assay system and uses thereof. In particular, the present invention relates to lateral flow assay systems for the simple and inexpensive detection of biomolecules.... Agent: Northwestern University

20120015347 - Methods for assaying cellular binding interactions: There are provided methods, and devices for assaying for a binding interaction between a protein, such as a monoclonal antibody, produced by a cell, and a biomolecule. The method may include retaining the cell within a chamber having an aperture; exposing the protein produced by the cell to a capture... Agent:

20120015344 - Methods, compositions, and apparatus for the detection of viral strains: The disclosure generally relates to a particulate composition formed from a conductive polymer bound to magnetic nanoparticles. The particulate composition can be formed into a biologically enhanced, electrically active magnetic (BEAM) nanoparticle composition by further including a binding pair member (e.g., an antibody or a fragment thereof that specifically recognizes... Agent: 1. Board Of Trustees Of Michigan State University

20120015352 - Method of determining sensitivity of human or non-human animal cells to an iap antagonist: cFLIP serves as a biomarker for efficacy of treatment with IAP antagonists, including Smac peptidomimetics.... Agent: Otto-von-guericke-universitat Magdeburg

20120015353 - Method of determining the nucleotide sequence of oligonucleotides and dna molecules: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown... Agent: Helicos Biosciences Corporation

20120015351 - Mirna target prediction: The present invention relates to generation (e.g., synthesis) of proteins. In particular, the present invention provides methods to predict miRNA targets using sequence similarity and thermodynamic stability of miRNA-bridges across both 3′ and 5′ UTR. Such methods find use in research, diagnostic and therapeutic settings (e.g., to discover targets, drugs,... Agent: The Regents Of The University Of Michigan

20120015354 - Nucleic acid aptamer binder specifically to bisphenol a: A nucleic acid aptamer capable of binding specifically to bisphenol A and a method of detecting and removing bisphenol A using the nucleic acid aptamer. The nucleic acid aptamer capable of binding specifically to bisphenol A has affinity for bisphenol A at nM concentration, and thus can detect even a... Agent:

20120015356 - Connexin mutation detection for lymphatic variation and disease: Methods are provided for identifying risk of developing lymphedema, including primary and secondary edema. The methods comprise identifying the presence in a biological sample of a polymorphism in one or more of GJA4, GJA5 and GJC2, resulting in a functional mutation of one or more of connixin 37 (Cx37), Cx40... Agent: University Of Pittsburgh-of The Commonwealth System Of Higher Education

20120015359 - Methods for molecular detection: This invention relates to methods for molecular detection, particularly to methods utilizing target-specific molecular probes. In exemplary embodiments, target-specific molecular probes include single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) aptamers. In general, the molecular probe may bind with relatively high specificity to a given target. In one aspect, a... Agent: Biotex, Inc.

20120015358 - Orthogonal nucleic acid affinity pairs: The invention provides methods to identify pRNA- and pDNA oligomer affinity pairs. Affinity pairs comprised of nucleic acid oligomers which demonstrate no cross-reactivity (“orthogonal”) are designed using software and empirically verified by thermodynamic study and lateral flow testing. The design software uses a semi-random algorithm to build such sequences of... Agent: Elitech Holding B.v.

20120015357 - Prediction of lipid-metabotype-related physiological susceptibilities: The present invention relates to a method for determining a predisposition of a human subject for physiological susceptibilities that result from alterations in lipid metabolism, wherein the physiological susceptibilities are selected from sensitivity to functional food, physical health schemes, identification of non-responsiveness to treatment by diet or physical activity. The... Agent:

20120015355 - Size standards for use in nucleic acid analysis: A size standard, kit includes a size standard, method of defining a size standard and method of analysis using a size standard. The size standard is intended to include size standard elements which have a size greater than and/or less than and/or different from the components of a sample which... Agent: Forensic Science Service Limited

20120015368 - Biomarkers for early diagnosis of systemic tissue fibrosis: Embodiments of the invention provides methods, devices and kits for determining the likelihood of an individual having an active fibrotic condition and/or early diagnosis, and subsequently prognosis evaluation of an individual having an active fibrotic condition such as systemic sclerosis (SSc) and/or nephrogenic systemic fibrosis (NSF) by measuring the levels... Agent: Thomas Jefferson University

20120015362 - Compositions and methods for detecting cryptococcus neoformans: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Cryptococcus neoformans, a causative agent for human cryptococcosis. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the fungal specific transcription factor gene in Cryptococcus neoformans, are useful as forward and reverse... Agent: Medical Diagnostic Laboratories LLC

20120015360 - Compositions for use in identification of babesia bioagents: The present invention relates generally to the detection and identification of Babesia bioagents, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent: Ibis Biosciences, Inc.

20120015369 - Method for detecting a recombinant event: Methods relating to isolating and amplifying chimeric nucleic acid molecules are provided. The methods of the invention are useful for detecting chromosome translocation events associated with diseases or conditions, such as cancer.... Agent:

20120015364 - Method for the selection of endothelial cells death inducers via netrin-1 and its applications: The present invention relates to an in vitro method for selecting a compound capable to induce the death of endothelial cells, preferably endothelial cells from vessels or neovessels. The invention further comprises the use of netrin-1 function inhibitors as compounds capable to induce the death of endothelial cells, preferably endothelial... Agent: Centre Leon Berard

20120015366 - Methods and compositions to identify increased risk of breast cancer by detection of cpg island methylator phenotype (cimp): The present invention is directed to kits and methods for identifying a female subject as having an increased risk of developing breast cancer, comprising detecting a CPG island methylator phenotype (CIMP) in nucleic acid of the subject.... Agent: Duke University

20120015367 - Methods for multiplexing recombinase polymerase amplification: This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.... Agent:

20120015365 - Methods for testing the accuracy and thermal reliability of a pcr thermal cycler, and a means for implementing said methods: i

20120015370 - Multiplex compositions and methods for quantification of human nuclear dna and human male dna and detection of pcr inhibitors: The invention relates to a method for simultaneous quantification of human nuclear DNA and human male DNA in a biological sample while also detecting the presence of PCR inhibitors in a single reaction. The multiplex quantification method also provides a ratio of human nuclear and male DNA present in a... Agent: Applied Biosystems, LLC

20120015361 - Oligonucleotides for the detection of aspergillus species: The invention relates to oligonucleotides that are specific for the fungi belonging to Aspergillus genus, and which are able to hybridize to facC gene homologues present in those fungi and show homology with the facC gene of Streptomyces griseus 45H, the sequence of said homologous gene is identical with any... Agent:

20120015363 - Progesterone receptor membrane component 1(pgrmc1) as an indicator of human fertility: Methods of evaluating fertility of a human based on determination of a PGRMC1 characteristic that correlates with human fertility. In one embodiment, a sample is obtained from a human, a PGRMC1 characteristic is determined and compared to a baseline PGRMC1 characteristic, wherein a variation between the determined PGRMC1 characteristic and... Agent: University Of Connecticut

20120015373 - Acridone derivatives as labels for fluorescence detection of target materials: Z1 and Z2 represent atoms necessary to complete one ring, two fused ring, three fused ring aromatic or heteroaromatic systems, each ring having five or six atoms selected from carbon atoms and optionally no more than two atoms selected from oxygen, nitrogen and sulphur; R2, R3, R4 and R5 are... Agent: Ge Healthcare Uk Limited

20120015374 - Enigma-mdm2 interaction and uses thereof: The present invention relates to Enigma (PDLIM7)-Mdm2 interaction and use thereof. More particularly, it may induce an effective apoptosis of cancer cells by inhibition of an Enigma expression or an Enigma activity which induces Mdm2 destabilization and p53 activity; it may assess the prognosis of anti-cancer therapy by determining that... Agent: Korea Research Institute Of Bioscience And Biotechnology

20120015375 - Mcm6 and mcm7 monoclonal antibodies and methods for their use in the detection of cervical disease: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided.... Agent: Tripath Imaging, Inc.

20120015372 - Methods and compositions for pathogen detection using fluorescent polymer sensors: Compositions, methods and related apparatus, as can be used for selective pathogen detection and identification.... Agent: University Of Massachusetts

20120015371 - Methods for measuring concentrations of biomolecules: The present invention provides methods for measuring the absolute concentration of a biomolecule of interest in a subject. Such biomolecules may be implicated in one or more neurological and neurodegenerative diseases or disorders. Also provided is a method for determining whether a therapeutic agent affects the in vivo metabolism of... Agent: C2n Diagnostics

20120015376 - Free solution measurement of molecular interactions by backscattering interferometry: Disclosed are methods, systems, and apparatuses for the free solution measurement of molecular interactions by backscattering interferometry (BSI). Molecular interaction can be detected between analytes in free-solution wherein at least one of the analytes is label-free and detection is performed by back-scattering interferometry. Further, molecular interaction can be detected between... Agent: Vanderbilt University

20120015378 - Identification of bitter ligands that specifically activate human t2r receptors and related assays for identifying human bitter taste modulators: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. The invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by these bitter ligands... Agent:

20120015377 - Method and apparatus for measuring biogenous biologically active substance: Provided is an assay method and an assay device whereby assay time can be largely shortened in the case of detecting a physiologically active substance of biological origin. The aggregation start time of a liquid mixture of an assay sample with LAL is determined. From this aggregation start time, the... Agent: Kowa Company, Ltd.

20120015379 - Diagnosis of bacillus anthracis infection based on detection of bacterial secreted biomarkers: A novel and rapid diagnostic method for anthrax infection is provided. Three B. anthracis gene products are described, as well as antibodies against the same, which may be used for the detection and monitoring of anthrax infection. Kits for the diagnosis of anthrax are also provided.... Agent: State Of Israel, Represented By Prime Minister's Office

20120015380 - Anti-polyethylene glycol antibody expressing cell quantify any free polyethylene glycol and polyethylene glycol-derivatized molecules: In this invention, anti-PEG antibodies or anti-methoxyl-PEG (anti-CH3O-PEG) antibodies were expressed on cell surface which can collocate with a biotinylated anti-PEG antibody (AGP4-Biotin) or biotinylated PEG (PEG-Biotin) to develop a cell-based sandwich ELISA or a cell-based competition ELISA, respectively. Both of these two methods could sensitively quantify free PEG and... Agent: Kaohsiung Medical University

20120015385 - Doxorubicin immunoassay: Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are useful in immunoassays for the quantification and monitoring of doxorubicin in biological fluids.... Agent:

20120015382 - Droplet-based selection: The present invention generally relates to fluidic droplets, and techniques for screening or sorting such fluidic droplets. In some embodiments, the fluidic droplets may contain cells (e.g., hybridoma cells) that can secrete various species, such as antibodies, for example. In one aspect, a plurality of fluidic droplets containing cells is... Agent: The General Hospital Corporation D/b/a Massachusetts General Hospital

20120015384 - Interleukin-1 alpha antibodies and methods of use: Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.... Agent: Xbiotech, Inc.

20120015386 - Ip-10 based immunological monitoring: The present invention relates to an immunological method and, more particularly, a method for measuring cell-mediated immune reactivity (CMI) in mammals based on the production of IP-10. The invention further discloses an assay and a kit for measuring CMI to an antigen using whole blood or other suitable biological samples.... Agent: Hvidovre Hospital

20120015381 - Methods and kits for the differential diagnosis of alzheimer's disease versus frontotemporal dementia and for the diagnosis of frontotemporal dementia, comprising fas-l and ck 18 as biomarkers: The invention relates to methods and kits for the differential diagnosis of Alzheimer's disease (AD) versus frontotemporal dementia (FTD), using biomarkers TNF-α, FAS-L and CK18, taken from a biological sample. Differences in biomarker levels can be used to distinguish between AD and FTD The invention is based on a discovered... Agent:

20120015383 - Novel diagnostic marker for type 1 diabetes mellitus: The present invention provides, as a novel diagnosis marker for type 1 diabetes mellitus, a type 1 diabetes mellitus diagnostic composition comprising alanyl-tRNA synthetase, glycyl-tRNA synthetase, asparaginyl-tRNA synthetase, or tryptophanyl-tRNA synthetase, a diagnostic kit comprising the same, and a diagnostic method using the same. The composition, the kit, and the... Agent: Seoul National University Hospital

20120015387 - Marker peptides for determining the occurrence of an inflammatory state in a subject: An enzyme proteolysis-resistant peptide that binds to antibodies directed against the amino acid region 1-116 of the endocan's polypeptide sequence, which peptide possesses an apparent molecular weight of 14 kDa.... Agent: Institut Pasteur De Lille

20120015388 - Diluent for preparing analytical sample: The ionic strength of a diluent for preparing an analytical sample is set to be 0.06 to 0.16. The analytical sample prepared by using the diluent having the ionic strength within this range can be subjected to both for analyzing a first object in a test sample by electrode method... Agent: Arkray, Inc.

20120015389 - Method and device for measuring the activity of enzymes after de-inhibition: The present invention relates to a method for measuring the activity of enzymes in a sample which contains at least one enzyme and at least one enzyme inhibitor corresponding to said enzyme, whereby after de-inhibition the activity of the released enzyme is measured in such a way that a substrate... Agent:

20120015390 - Methods for the detection and treatment of aberrant prion disease: The invention relates to methods and tools for detecting and treating patients suffering from aberrant prion functioning or Aberrant Prion Disease (APD), methods for determining the presence of aberrant prion functioning-inducing agents in a sample and to methods for determining the appropriate therapy for a patient having symptoms of aberrant... Agent: Protea Biopharma N.v.

20120015391 - Biochemical reactor: A biochemical reactor involves an online cell examination microscope (4) thereon. Said online cell examination microscope (4) comprises a main body (43), an objective lens (24), an observation entrance window (22), a sampling device (40), an external light source system (60). Said observation entrance window (22) lies in front of... Agent: Shanghai Cohere Electronics Technology Co., Ltd.

20120015392 - Cell counting slide with lateral reservoir for promoting uniform cell distribution: Cells in a suspension are counted in a hemocytometer slice with a chamber of controlled depth and one or more reservoirs along one or more side edges of the chamber. The suspension is fed to a reservoir to first fill the reservoir, and then to overflow into the chamber. The... Agent: Bio-rad Laboratories, Inc.

20120015396 - Compositions and methods for modulating the acid-sensing ion channel (asic): Novel compositions for modulating acid-sensing ion channels (ASIC) function comprising ASICα, ASICβ, and BNC1 and derivatives thereof; methods for modulating ASIC function and methods for treating cognitive disorders and for memory enhancement using the novel compositions of the invention; and a method for increasing synaptic plasticity are described.... Agent: University Of Iowa Research Foundation

20120015393 - Endogenous auto-fluorescent biological markers for assessing a biological parameter of a cell: The present application relates to the use of endogenous fluorescent biological markers to determine a biological parameter of a cell in a liquid. The methods provided herein provide accurate results in a relatively short amount of time and can be used to monitor and optimize cell culture online as well... Agent:

20120015395 - Human blood-brain barrier endothelial cells derived from pluripotent stem cells and blood-brain barrier model thereof: A model blood brain barrier obtained from hPSCs is disclosed.... Agent:

20120015394 - Transfer unit and method for receiving a medium from a processing device: The invention relates to a transfer unit for receiving in particular a porous disc-shaped medium from a first treatment device, having an upper part, wherein the upper part comprises a fixing edge that can be connected to an edge of the medium for removing the medium from the first treatment... Agent: Sartorius Stedim Biotech Gmbh

20120015397 - Periodontal disease marker (as amended herewith): A marker for determining the onset of periodontal disease and a marker for determining the progression stage of periodontal disease, each containing autoinducer-2.... Agent: Kao Corporation

20120015398 - Method for the detection of acid production by cariogenic bacteria: The present invention relates to a method for the semi-quantitative determination of cariogenic bacteria in a sample of saliva and/or plaque, in which the microorganisms contained in a sample of plaque or saliva are brought into contact with a carbon source that is fermented to acid by the cariogenic bacteria.... Agent: Ivoclar Vivadent Ag

20120015399 - Fluorescent solvatochromic pigment: A pyridinium group was introduced to the electron attracting group of the neutral fluorescent solvatochromic dye (Japanese Patent Application Public Disclosure No. 20008-291210 A) displaying an excellent emission wavelength response and synthesized a fluorescent solvatochromic dye. Then it was found that the fluorescence wavelength of the fluorescent solvatochromic dye changed... Agent: National University Corporation Hokkaido University

20120015400 - Hcl-k1 polypeptide which offers collectin activity: Disclosed is the novel hCL-K1 polypeptide which offers collectin activity. This polypeptide consists of consecutive 271 amino acids set out in SEQ ID NO: 2 and does not bind to both maltose and N-acetylgalactosamine.... Agent: Fuso Pharmaceutical Industries, Ltd.

20120015401 - Plasmodium falciparum antigens and methods of use: The subject invention provides novel Plasmodium falciparum antigens and novel polynucleotides encoding these antigens. Also provided by the subject invention are methods of using these antigens and polynucleotides.... Agent: Epimmune Inc.

20120015403 - Production and purification of il-29: The expression vectors and methods using an E. coli expression system for the large scale production of IL-29 are described. The vectors utilize the IL-29 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Also included are methods... Agent: Zymogenetics, Inc.

20120015402 - Method of proliferating plasma cells: The present inventors discovered that, when cancer tissues comprising infiltrating lymphocytes are transplanted into highly immunodeficient animals that do not have T cells, B cells, and NK cells and further exhibit a low IFN production ability, the differentiation and proliferation of infiltrating lymphocytes are unexpectedly promoted, and the number of... Agent: Pharmalogicals Research Pte. Ltd.

20120015404 - Gene cluster for thuringiensin synthesis: The invention belongs to the technical field of genetic engineering of agricultural microorganisms. Specifically, the invention relates to producing and using gene cluster for thuringiensin synthesis from Bacillus thuringiensis. The gene cluster includes 11 genes of thuA, thuB, thuC, thuD, thuE, thuF, thuG, thu1, thu2, thu3 and thu4. These genes... Agent: Huazhong Agricultural University

20120015405 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecular Systems, Inc.

20120015406 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent:

20120015408 - Beta-glucosidase variant enzymes and related polynucleotides: The invention provides variants of the Thermoanaerobacter brockii CglT beta-glucosidase that have improve beta-glucosidase activity compared to the wild type enzyme. The invention also provides polynucleotides that encode the variants, as well as methods of producing the variants, enzyme compositions comprising the variants, and methods for using the variants in... Agent: Codexis, Inc.

20120015407 - Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic... Agent: Battelle Energy Alliance, LLC

20120015409 - Process for producing l-amino acid: o

20120015410 - Pyripyropene a biosynthetic gene: An isolated novel polynucleotide comprising a nucleotide sequence encoding at least one polypeptide involved in biosynthesis of pyripyropene A, a recombinant vector comprising the polynucleotide and a transformant comprising the polynucleotide are disclosed. By the present invention, a pyripyropene A biosynthetic gene useful for production of a novel pyripyropene analog,... Agent:

20120015411 - Manufacture of maleic anhydride from renewable materials, maleic anhydride obtained, and uses thereof: The present application relates to a process for manufacturing maleic anhydride that comprising the following steps: a) fermentation of renewable raw materials and optionally purification to produce a mixture comprising at least butanol; b) oxidation of the butanol to maleic anhydride at a temperature generally between 300° C. to 600°... Agent: Arkema France

20120015412 - Preparation of pregabalin and related compounds: Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.... Agent: Pfizer Inc

20120015413 - Microorganisms with extended substrate utilization range: The present invention relates to a microorganism of the genus Cupriavidus or Ralstonia, which is genetically modified to express phosphomannose isomerase (EC5.3.1.8) and facilitated diffusion protein for mannose uptake (EC1.3.1.74), and optionally mannofructokinase (EC2.7.1.4) and/or xylose isomerase (EC 5.3.1.5), xylulokinase (E 2.7.1.17) and xylose proton symporter E or a high... Agent: Neste Oil Oyj

20120015414 - Production of organic compounds: The present invention provides methods for the production of hydrocarbons, particularly alkanes and alkenes, using biosynthetic routes, as well as genes and enzymes involved therein.... Agent:

20120015415 - Method for producing succinic acid using a yeast belonging to the genus yarrowia: The present invention provides a method for producing succinic acid using a yeast belonging to the genus Yarrowia, which has been modified to reduce activity of succinate dehydrogenase in said yeast.... Agent:

20120015416 - Expression of hexose kinase in recombinant host cells: The invention relates to a recombinant host cell having (a) a modification in an endogenous polynucleotide encoding a polypeptide having dual-role hexokinase activity; (b) a heterologous polynucleotide encoding a polypeptide having hexose kinase activity; and optionally (c) a modification in an endogenous polynucleotide encoding a polypeptide having pyruvate decarboxylase activity.... Agent: Butamax(tm) Advanced Biofuels LLC

20120015417 - Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids: The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or... Agent: Gevo, Inc.

20120015418 - Genes and proteins for the biosynthesis of the lantibiotic 107891: The invention relates to the field of lantibiotics, and more specifically to the isolation of nucleic acid molecules that code for the enzymes required for the biosynthetic pathway of the lantibiotic 107891 and the homologues thereof.... Agent: Sentinella Pharmaceuticals ,inc.

20120015419 - Method and apparatus for headspace control in acoustic processing of samples: Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic... Agent: Covaris, Inc.

20120015420 - Delta-8 desaturase and its use in making polyunsaturated fatty acids: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast are disclosed.... Agent:

20120015421 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent:

20120015422 - Fermentation broth formulations: The present disclosure relates to fermentation broth formulations containing organic acids and/or organic acid salts, and methods of making and using such formulations.... Agent:

20120015423 - Intergenic regions as novel sites for insertion of hiv dna sequences in the genome of modified vaccinia virus ankara: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.... Agent:

20120015424 - Arginine inactivation of viruses: The present invention pertains to methods of using arginine to inactivate or reduce the infectious titer of enveloped viruses potentially present in biological compositions produced by eukaryotic cells (such as a antibodies or other therapeutic proteins). In some embodiments, inactivation or reduction of viral titers by exposure to arginine is... Agent: Biogen Idec Ma Inc.

20120015425 - Cellular permissivity factor for viruses and uses thereof: The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus.... Agent: Pharmacia And Up John Company, LLC

20120015426 - Bacteria for high efficiency cloning: Disclosed are novel bacterial hosts that are capable of high efficiency transformation with methylated and/or unmethylated nucleic acids, and that are bacteriophage resistant. Such bacteria contain: (1) an F′ episome that confers high efficiency transformability; (2) one or more mutations that allow transformation of methylated nucleic acids; (3) one or... Agent: Life Technologies Corporation

20120015427 - Ethanol production in microorganisms: The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium.... Agent: Joule Unlimited Technologies, Inc.

20120015428 - Metering rotary nanopump, method of fabricating same, and applications of same: In one aspect of the present invention, a pump includes a cam having a cam shaft, wherein the cam shaft has an axis, an exterior surface and M fins spaced-apart formed on the exterior surface along the axis; and at least one fluidic flow channel having an inlet and an... Agent: Vanderbilt University

20120015429 - Quantitative lateral flow system and assay: The present invention relates to a lateral flow assay and system, including a test strip, for detection and quantification of analytes in samples, such as samples containing cells and fluid. In general, according to the present invention, a test strip for a lateral flow assay for detection of at least... Agent: Relia Diagnostic Systems, Inc

20120015430 - Systems and methods for digestion of solid waste: This invention relates generally to systems and methods for digestion of solid waste that simplify solids handling. In certain embodiments, anaerobic methane extraction takes place for a period of time (e.g., from 1 to 4 weeks), after which an aerobic composting process begins in the same chamber. The organic waste... Agent:

20120015431 - Petri-dish for cell cultivation and microscopy: A dish for cell cultivation and microscopy is provided, comprising a ring and an outer ridge upwardly and axially protruding therefrom, wherein the ring is covered at its bottom side with a transparent membrane and, thus, forms a recess delimited by the inner side of the ring and the membrane,... Agent:

20120015434 - Expansion of nk cells and therapeutic uses thereof: The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.... Agent: St. Jude Children's Research Hospital

20120015433 - Interleukin-1 alpha antibodies and methods of use: Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.... Agent: Xbiotech, Inc.

20120015432 - Isolated bitter taste receptor polypeptides: The claimed invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R61 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor.... Agent:

20120015436 - Degraded tpo agonist antibody: The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking TPO receptor to thereby exert TPO agonist action. The modified antibody can be used... Agent: Chugai Seiyaku Kabushiki Kaisha

20120015435 - Pcsk9 antagonists: The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The... Agent: Rinat Neuroscience Corp.

20120015437 - Long-acting polypeptides and methods of producing same: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention... Agent:

20120015438 - Mammallian cell culture process for protein production: The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, preferably, but not limited to, fed-batch cell cultures. In one aspect, the methods comprise at least two temperature shifts performed during the culturing period, in which the temperature is... Agent: Bristol-myers Squibb Company

20120015439 - Method for the reconstruction of a tissue-engineered human corneal endothelium: This invention relates to a method for the reconstruction of a tissue-engineered human corneal endothelium. Human corneal endothelial cells are cultured in vitro to logarithmic growth phase using 20% calf bovine serum-containing DMEM/F12 medium. Trypsin is used to digest epithelial layer of the freeze-dried human amniotic membrane in order to... Agent: Ocean University Of China

20120015440 - Spheroid composite, spheroid-containing hydrogel and processes for production of same: A spheroid composite includes: a substrate including a cell-adhesive porous base material and plural hydrophilic regions and hydrophobic regions that are disposed on the porous base material and formed by curing a photosensitive composition, wherein the photosensitive composition includes a branched polyalkylene glycol derivative having three or more polyalkylene glycol... Agent: Tokyo University Of Science Educational Foundation Administrative Org.

  
01/12/2012 > 125 patent applications in 69 patent subcategories. recently filed with US Patent Office

20120009559 - Automated cell culture system and process: The present invention relates generally to the field of cell culture, which is a laboratory process used primarily for the growth, propagation, and production of cells for analysis and the production and harvesting of cell products. The present invention comprises functionalized and/or engineered hydrogel microcarriers that exhibit any or all... Agent: Global Cell Solutions, LLC

20120009558 - Method and apparatus for identification of bacteria: An automated system for identifying in a biological sample microorganisms and their antimicrobial susceptibility (AST). The system provided an automated platform for preparing, from a single biological sample, inoculates for both ID and AST. The system loads a plate for ID testing as samples are being prepared for AST testing.... Agent: Becton, Dickinson And Company

20120009565 - Compositions and methods for detection of hepatitis a virus nucleic acid: Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences are disclosed.... Agent: Gen-probe Incorporated

20120009562 - High-risk human papillomavirus detection: This invention provides compositions and methods for detecting HPV in a sample. This invention also provides related kits, systems, and computers.... Agent: Roche Molecular Systems, Inc.

20120009563 - High-risk human papillomavirus detection: This invention provides compositions and methods for detecting HPV in a sample. This invention also provides related kits, systems, and computers.... Agent: Roche Molecular Systems, Inc.

20120009564 - High-risk human papillomavirus detection: This invention provides compositions and methods for detecting HPV in a sample. This invention also provides related kits, systems, and computers.... Agent: Roche Molecular Systems, Inc.

20120009566 - Luminescence assay method: A bioassay employing a first group including a lanthanide ion carrier chelate and a first recognition element, a second group including an antenna ligand and a second recognition element; where the lanthanide ion carrier chelate binds strongly to lanthanide, or the lanthanide ion carrier chelate binds moderately to lanthanide, and... Agent:

20120009560 - Method for purifying nucleic acids from microorganisms present in liquid samples: The present invention relates to a method for treating liquid samples with a view to detecting any possible pathogenic microorganisms in a very small amount. More specifically, this method comprises a generic step of capturing and concentrating microorganisms on an ion exchange surface, followed by an in situ lysis treatment... Agent:

20120009561 - Methods of evaluating a test agent in a diseased cell model: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and... Agent: Sanofi Pasteur Vaxdesign Corp.

20120009569 - Microorganism concentration process and device: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising... Agent:

20120009567 - Sequencing reactions with alkali metal cations for pulse width control: Compositions, kits, methods and systems for single molecule nucleotide sequencing comprising producing polymerase reactions having monovalent cations that control the median pulse width for incorporated nucleotides are disclosed. The levels of alkali metals such as lithium, sodium, potassium, rubidium, and cesium in the polymerization are used to control pulse width... Agent: Pacific Biosciences Of California, Inc.

20120009568 - Thermoelectric method of sequencing nucleic acids: The present invention relates to a novel thermoelectric method for determining the sequence of nucleotides on a nucleic acid molecule through use of a thermopile and/or sequencing reagents flowing under the conditions of laminar flow. The methods disclosed herein involve the measurement of the heat generated by a deoxynucleotide incorporation... Agent:

20120009573 - antisense transcriptomes of cells: Transcription in mammalian cells can be assessed at a genome-wide level, but it has been difficult to reliably determine whether individual transcripts are derived from the Plus- or Minus-strands of chromosomes. This distinction can be critical for understanding the relationship between known transcripts (sense) and the complementary antisense transcripts that... Agent: The Johns Hopkins University

20120009574 - Detection of listeria species in food and environmental samples, methods and compositions thereof: Embodiments of the disclosure relate to isolated nucleic acid sequences, methods of use thereof, and workflows for detection of several Listeria species in a sample, particularly in a food or environmental sample. Embodiments of the disclosure may also be used to detect one or more species or strains of Listeria... Agent: Life Technologies Corporation

20120009577 - Detection of nucleic acids through amplification of surrogate nucleic acids: Methods for detecting and optionally quantitating one or more target nucleic acids are provided, in which a surrogate nucleic acid is captured to each target nucleic acid, amplified, and detected. Compositions, kit, and systems related to the methods are also described.... Agent: Affymetrix, Inc.

20120009575 - Inducible nucleic acid targets for detection of pathogens, methods and compositions thereof: The present application describes compositions, methods and kits for rapid detection and identification of various microorganisms using inducible RNA. Methods for rapidly detecting microorganisms by detecting expression of inducible RNA of target genes following induction of a target gene using an inducer are described. Some embodiments describe methods and workflows... Agent: Life Technologies Corporation

20120009580 - Methods for quantitating small rna molecules: In one aspect, the present invention provides methods for amplifying a microRNA molecule to produce DNA molecules. The methods each include the steps of: (a) using primer extension to make a DNA molecule that is complementary to a target microRNA molecule; and (b) using a universal forward primer and a... Agent: Merck Sharp & Dohme Corp.

20120009578 - Microvesicle-based compositions and methods: Methods and compositions for diagnosis and/or analysis of a condition in a mammal are disclosed in which RNA from microvesicles is enriched and differentiated to so obtain a result that is indicative of the condition of tissue or organ from which the microvesicle originated. In especially preferred embodiments, the condition... Agent: Proxy Life Science Holdings, Inc.

20120009579 - Monocyte-derived nucleic acids and related compositions and methods: Nucleic acids encoding various monocyte-derived proteins and related compositions, including purified proteins and specific antibodies are described. Methods of using such composition are also provided.... Agent: Schering Corporation

20120009572 - Novel single nucleotide polymorphisms and community-associated methicillin-resistant staphylococcus aureus: The present invention is based on the discovery of novel polymorphisms (SNPs) in the penicillin binding protein (pbp3) gene in Staphylococcus aureus. The presence of G88A and/or G2047A SNPs provides an accurate, reliable biomarker for the presence of Methicillin Resistant Staphylococcus aureus (MRSA), specifically the community-associated MRSA (CA-MRSA). The present... Agent: Medical Diagnostic Laboratories, LLC

20120009576 - Probe for detection of polymorphism in abl gene, and use thereof: (P1) an oligonucleotide comprising a nucleotide sequence complementary to a nucleotide sequence of 10 to 50 consecutive nucleotides containing nucleotides 125 to 133 in SEQ ID NO:1 or 2 or a homologous sequence thereof, wherein the nucleotide corresponding to the nucleotide at position 125 is cytosine and labeled with a... Agent: Arkray, Inc.

20120009570 - Restoration of nucleic acid from degraded or formalin-fixed and paraffin-embedded tissue and uses thereof: This invention provides methods, primers and kits for restoration of nucleic acid from tissue, in particular degraded tissue and formalin-fixed and paraffin-embedded (FFPE) tissue, where the methods involve complementary-template reverse-transcription (CT-RT) where short single-stranded DNA sequences reverse-transcribed from mRNA are used for reverse-transcription of complementary sense-RNA templates. The methods can... Agent:

20120009571 - Tmprss2 for the diagnosis of prostate disease: Described herein are methods, compositions and kits directed to the detection the 5′ portion of TMPRSS2 mRNA for the detection and diagnosis of prostate disease including prostate cancer and benign prostatic hyperplasia.... Agent:

20120009582 - Diagnosis and treatment of breast cancer: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to compositions and methods for the prediction of a subject's response to cancer therapies.... Agent: The Regents Of The University Of Michigan

20120009581 - Gene expression profiling for predicting the survivability of prostate cancer subjects: A method is provided in various embodiments for determining a profile data set for predicting the survivability of a subject with prostate cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification under measurement conditions that are substantially repeatable... Agent:

20120009584 - Method for detecting and qunantifying endogenous wheat dna sequence: It is an object of the present invention to provide partial sequences of endogenous wheat DNA (genome) which are single copies and which allow wheat to be specifically detected without cross-reacting with other plants in PCR, and to provide primers for amplifying these partial sequences, along with a good method... Agent: Nisshin Seifun Group Inc.

20120009585 - Method for detecting and qunantifying endogenous wheat dna sequence: It is an object of the present invention to provide partial sequences of endogenous wheat DNA (genome) which are single copies and which allow wheat to be specifically detected without cross-reacting with other plants in PCR, and to provide primers for amplifying these partial sequences, along with a good method... Agent: Nisshin Seifun Group Inc.

20120009586 - Method for detecting and qunantifying endogenous wheat dna sequence: It is an object of the present invention to provide partial sequences of endogenous wheat DNA (genome) which are single copies and which allow wheat to be specifically detected without cross-reacting with other plants in PCR, and to provide primers for amplifying these partial sequences, along with a good method... Agent: Nisshin Seifun Group Inc.

20120009583 - Method for producing highly sensitive endonucleases, novel preparations of endonucleases and uses thereof: The present invention pertains to methods for producing recombinant endonucleases having a high sensitivity, as well as to endonucleases preparations obtained by said methods, and uses thereof, especially for the detection of mismatches.... Agent: Genoplante-valor

20120009588 - Live bioload detection using microparticles: The present invention provides methods to concentrate cells onto microparticles, to concentrate the microparticles, and to detect the cells. The present invention also includes unitary sample preparation and detection devices to be used in accordance with the methods.... Agent:

20120009587 - Recombinant adenovirus target-oriented co-expressing human p53 and p53aip1: A recombinant adenovirus target-oriented co-expressing human p53 variant and p53AIP1 is disclosed, which is inserted an expression cassette co-expressing human p53 variant and p53AIP1 in E1 deletion region of the adenovirus. The expression cassette consists of tumor specific promoter, human p53 variant, internal ribosome entry site (IRES), human p53AIP1, and... Agent:

20120009589 - Sub-diffraction image resolution and other imaging techniques: The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be... Agent: President And Fellows Of Harvard College

20120009590 - Device and non-toxic compositions and methods for permeabilization of drosophila embryos: The invention provides compositions and methods for permeabilizing insect embryos by removing the waxy layer of the shell using a solution containing a non-toxic cyclic terpene and a non-toxic surfactant, preferably a non-ionic surfactant. The invention further provides kits to practice the method of the invention. The invention also provides... Agent: The University Of Vermont And State Agriculture College

20120009591 - Method for detection of an enzyme-substrate reaction: The present invention relates to a method for detection of an enzyme-substrate reaction by capturing the product of the reaction on a solid support. More closely, the invention relates to a solid phase system for enzyme characterisation and screening of enzyme-targeted drugs. The method comprises the following steps a) rapidly... Agent:

20120009597 - Biomarker for barrett's oesophagus: The present invention relates to the use of TFF3 in the diagnosis and detection of Barrett's Oesophagus using non-invasive, non-endoscopic methods.... Agent: Medical Research Council

20120009599 - Method for detecting membrane protein internalization: e

20120009600 - Method of diagnosing adolescent idiopathic scoliosis: A method for diagnosing an increased risk for developing adolescent idiopathic scoliosis (AIS) in a human subject, comprising detecting the presence or absence of at least one impairment in melatonin-signaling pathway in a cell sample of the subject in the presence and in the absence of a known melatonin-signaling pathway... Agent: Hopital Sainte-justine

20120009601 - Methods and compositions for reprogramming cells: The present invention is directed, in part, to methods and compositions comprising inhibitors of micro RNA-145 and activators of the TGF-β signaling pathway to permit reprogramming using only small molecule compounds. Also described herein are methods to distinguish cancer cells or cells having cancerous potential in human iPS cell populations,... Agent: The General Hospital Corporation

20120009596 - Protein markers for detecting liver cancer and method for identifying the markers thereof: The present invention relates to the diagnosis of liver cancer. It discloses the use of protein ERBB3 and protein IGFBP2 in the diagnosis of liver cancer. It relates to a method for diagnosis of liver cancer from a liquid sample, derived from an individual by measuring ERBB3 protein and IGFBP2... Agent:

20120009598 - T2r, a novel family of taste receptors: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.... Agent: The Regents Of The University Of California

20120009602 - Reagents and methods for assessment of human tumor malignancy and for targeting malignant tumor cells: The disclosure relates to a monoclonal antibody, designated MAbH11B2C2, that binds specifically with a human hyaluronan-binding protein, designated H11B2C2. This protein can occur in two forms, one (apparently expressed by all malignant cells) having an apparent molecular size (as assessed by SDS-PAGE) of about 57 KDa, and another having an... Agent:

20120009593 - Analysis method for the in vitro diagnosis of benign prostatic hyperplasia (bph) in dogs by assaying canine prostate specific esterase, and bph treatment follow up: The invention relates to an analysis method for the in vitro diagnosis of benign prostatic hyperplasia (BPH) in a dog, using the CPSE contained in biological fluid samples collected from the dog as well as biological molecules specifically binding CPSE. The invention is characterised in that it includes the following... Agent: Virbac Sa

20120009592 - Enpp1 (pc-1) gene haplotype associated with the risk of obesity and type 2 diabetes and their applications: The present invention is directed to a method for determining if a subject is at increased risk to develop obesity or pathology related to obesity by determining the presence of a haplotype comprising three specific SNPs in a DNA or RNA sample of this subject and/or an elevated serum ENPP1... Agent: Centre National De La Recherche Scientifique (cnrs)

20120009594 - Method for measuring beta-glucan, and beta-glucan-binding protein for use in the method: Disclosed are a method for measuring βG comprising the steps of bringing a sample into contact with a βG-binding protein 1 and a βG-binding protein 2, each comprising an amino acid sequence which is identical or substantially identical to an amino acid sequence shown in any one of SEQ ID... Agent: Wako Pure Chemical Industries, Ltd.

20120009595 - Binding of aggregated forms of proteins: Aggregating proteins such as IgG, are bound selectively in the presence of the non-aggregated protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine at mildly alkaline pH, and may then... Agent: Microsens Biophage Limited

20120009607 - Differentiating cardiac- and diabetes mellitus-based causes of kidney damage: Disclosed is a method for differentiating in a subject suffering from kidney damage between kidney damage caused by (i) heart failure and/or (ii) diabetes mellitus type 1 or type 2 including the steps of: a) determining the amount of liver-type fatty acid binding protein (L-FABP) and the amount of kidney... Agent:

20120009603 - Method for increasing and regulating light emission from a chemiluminescent reaction: Method for increasing and regulating the emission of light from a chemiluminescent reaction including luminol, a peroxidase enzyme, an oxidant and an electron mediator (primary enhancer) through the use of an acylation catalyst (secondary enhancer) belonging to the class of N-azoles., i.e., a class of five-membered nitrogen heteroaromatic ring compounds... Agent: Cyanagen S.r.l.

20120009605 - New assays for preimplantation factor and preimplantation factor peptides: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently... Agent: Bioincept, LLC

20120009606 - Peptide biomarkers predictive of renal function decline and kidney disease: The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in... Agent: University Of Louisville Research Foundation, Inc.

20120009604 - Use of grf1 protein for screening molecules: The invention concerns the use of whole or part of the GRF1 protein, or of cells expressing whole or part of the GRF1 protein, in methods for detecting compounds for preventing and/or treating pathologies or disorders of the central nervous system involving neuronal death, such as apoptosis, or related to... Agent: Aventis Pharma Sa

20120009608 - Biomarker for the monitoring and prognosis of chronic myeloproliferative disorders: The invention provides a method for monitoring the progression of a myeloproliferative disease, particularly Polycythemia Vera (PV) and Essential Thrombocythemia (ET), or the response to pharmacological treatment with JAK2 inhibitors in a patient diagnosed positive for the same disease, or a method for predicting thrombotic events in a patient affected... Agent: Humanitas Mirasole S.p.a.

20120009609 - Devices and methods for detecting amniotic fluid in vaginal secretions: The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies.... Agent: N-dia, Inc.

20120009610 - Endostatin as a marker of heart failure: Disclosed is a method for assessing heart failure in an individual including the steps of a) measuring in a sample obtained from the individual the concentration of the marker endostatin, of b) optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of... Agent:

20120009611 - Biosensor and biosensor manufacturing method: A biosensor manufacturing method including a sheet material forming process and a dicing process. In the sheet material forming process a sheet material with plural biosensor forming sections is formed. Each of the biosensor forming sections includes a first base plate, a second base plate stacked on the first base... Agent: Arkray, Inc.

20120009612 - Method to detect and monitor compartment syndrome: Disclosed is a method of detecting and/or monitoring ischemia in a muscle tissue or compartment. The method includes the steps of measuring in real time or near-real time interstitial glucose concentration, or rate of change of interstitial glucose concentration over time, or both, in the muscle tissue or compartment. A... Agent:

20120009613 - Pharmaceutical composition for modulating the activity of a novel triglyceride hydrolase: Use of an inhibitor or activator of the triglyceride hydrolyse activity of a protein comprising a polypeptide strand encoded by the DNA sequence according to SEQ No. 1 for the preparation of a pharmaceutical composition for the treatment of medical disorders where it is desirable to modulate the activity of... Agent: Karl-franzens-universitat Graz

20120009614 - Thyroglobulin quantitation by mass spectrometry: Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated,... Agent: Quest Diagnostics Investments Incorporated

20120009616 - Detection of oligosaccharides: Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation.... Agent: Zacharon Pharmaceuticals Inc.

20120009615 - Dipyrromethene-boron hydrophilic fluorescent compounds: o

20120009618 - Endothelial cell production by programming: The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects.... Agent: Cellular Dynamics International, Inc.

20120009619 - Unitary cartridge for particle processing: A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves... Agent: Cytonome/st, LLC

20120009617 - Zinc sensors for cellular imaging: This present invention provides new compounds for use as zinc ligand sensors in cellular imaging. These compounds are highly sensitive imagining agents that can be used with techniques such a laser scanning microscopy in intact cells in culture or in tissue preparations.... Agent:

20120009620 - Method for reducing entrainment in a staining device: During operation of a staining device (20) including a first container (22) filled with a first process medium (23) and a second container (24) filled with a second process medium (25), samples (26) to be stained are immersed in the first process medium (23). A speed representative of how fast... Agent: Leica Biosystems Nussloch Gmbh

20120009622 - Alpha5-beta1 antibodies and their uses: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided.... Agent:

20120009623 - Methods for recombinant manufacturing of anti-rsv antibodies: The invention relates to a method for manufacturing recombinant anti-RSV antibodies and antibody compositions. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one distinct anti-RSV antibody. The cells... Agent: Symphogen A/s

20120009621 - Novel antibody and antibody fragment introduced new modification sites: The present invention relates to an antibody or antibody fragment comprising novel Cys residue, to which a hydrophilic macromolecular group or amphipathic macromolecular group can be bound at a high efficiency. In addition, the present invention relates to a monoclonal antibody modified product or an antibody fragment modified product in... Agent: Kyowa Hakko Kirin Co., Ltd

20120009624 - Protein particles: The invention relates to a protein particle comprising chimeric protein having an aggregating part capable of forming or aggregating into a substantially insoluble protein particle when expressed by a cell; and a functional part capable of binding to, or being bound by, a target compound. Affinity matrixes comprising the protein... Agent:

20120009625 - Secretion expression of antibiotic peptide cad in bacillus subtilis and expression system of recombination bacillus subtilis: The present invention relates to a method for expressing antimicrobial peptide CAD by means of a recombinant Bacillus subtilis expression system. The SUMO protease expression operon is first artificially synthesized. The protein expression operon genes of Saccharomyces cerevisiae small ubiquitin-related protein is then fused with the antibacterial peptide AD. The... Agent: Peking Sinagri Yin Thai Bio-technology Co., Ltd.

20120009626 - Biomass processing system and saccharide-solution production method using biomass material: A hydrothermal decomposition apparatus 17 as a biomass processing apparatus that decomposes a biomass material 11 into cellulose, hemicellulose, and lignin under a high temperature and high pressure condition to remove a lignin component and a hemicellulose component, a biomass solid discharging unit 18 that discharges a biomass solid (a... Agent: Mitsubishi Heavy Industries, Ltd.

20120009627 - Process and materials for production of glucosamine and n-acetylglucosamine: A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or N-acetylglucosamine. Also disclosed are genetically modified microorganisms that are useful for producing glucosamine and N-acetylglucosamine. In addition, methods of recovering N-acetylglucosamine that has been produced... Agent: Bio-technical Resourses

20120009628 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecular Systems, Inc.

20120009629 - Methods and kits for use in the selective amplification of target sequences: The present invention provides nucleic acid amplification methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplification reaction and/or that may be present in the environment in which an... Agent: Gen-probe Incorporated

20120009630 - Stabilized reverse transcriptase fusion proteins: Stabilized reverse transcriptase fusion proteins including a thermostable reverse transcriptase connected to a stabilizer protein are described. Attaching the stabilizer protein to the thermostable reverse transcriptase stabilizes the fusion protein and can aid in its purification, provide increased solubility, allow for longer storage, or allow the fusion protein to be... Agent: Board Of Regents, The University Of Texas System

20120009631 - Variant endoglucanases and related polynucleotides: The invention provides variants of the Clostridium thermocellum endoglucanase (CeIG) that have improved endoglucanase activity compared to the wild type enzyme. Also provided are related polynucleotides, compositions, vectors, host cells, and methods of use.... Agent: Codexis, Inc.

20120009632 - Process for producing alcohol and other bioproducts from biomass used in thermal conversion to energy and stepwise enzymatic hydrolysis process for cellulosic fiber: A method for the production of alcohol and other bioproducts hemicelluloses extracted from biomass prior to thermal conversion of the biomass to energy. The process can be integrated with the host plant process to minimize the energy loss from extracting hemicelluloses. Also disclosed is a Stepwise enzymatic break down of... Agent: American Process, Inc.

20120009633 - Nitrilases and methods for making and using them: The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia... Agent: Verenium Corporation

20120009634 - Aldolases, nucleic acids encoding them and methods for making and using them: This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such... Agent:

20120009635 - Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters: The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the... Agent: Danisco US Inc.

20120009636 - Methods and compositions for the recombinant biosynthesis of fatty acids and esters: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms, such that the organisms efficiently convert carbon dioxide and light into compounds such as esters and fatty acids. In certain embodiments, the compounds produced are secreted into the medium used to culture the organisms.... Agent: Joule Unlimited Technologies, Inc.

20120009637 - Nitrilases, nucleic acids encoding them and methods for making and using them: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.... Agent: Verenium Corporation

20120009638 - Syngas conversion method using asymmetric membrane and anaerobic microorganism: A stable method for producing liquid products such as ethanol, propanol, butanol and other chemicals from syngas components that contacts CO or a mixture of CO2 and H2 with a highly porous side of an asymmetric membrane under anaerobic conditions and transfers these components into contact with microorganisms contained within... Agent:

20120009639 - Controlling microbial contamination in alcoholic fermentation process: The control of the microbial contamination during the sugar fermentation in the processes for obtaining alcohol is a very important action to increase the productivity of the alcoholic fermentation processes. The Saccharomyces cerevisiae yeast cells engage a very tough nutritional competition for the sugarcane juice with the bacteria (Lactobacillus sp... Agent:

20120009640 - Fatty alcohol forming acyl reductases (fars) and methods of use thereof: The present disclosure provides methods useful for producing fatty alcohol compositions from recombinant host cells. The disclosure further provides variant fatty acyl-CoA reductase (FAR) enzymes, polynucleotides encoding the variant FAR enzymes, and vectors and host cells comprising the same.... Agent: Codexis, Inc.

20120009641 - Method for producing clarified juice, packagible juice, ethanol and sugar from sugarcane and system thereof: The present invention provides a method and system for manufacturing clarified juice from sugarcane without using sulfitation process and with less heating. The method comprises step of steps of: washing sugarcane with water comprising biocide before passing through cutter and shredders for removing mud and reducing microbial population; spraying biocide... Agent:

20120009642 - Biomass hydrothermal decomposition system and saccharide-solution production method using biomass material: A biomass hydrothermal decomposition system includes a hydrothermal decomposition unit 17 that transports the fed biomass material from a lower side to an upper side in an apparatus body 13 by screw means 14, feeds pressurized hot water 15 from an upper side different from a feed position of the... Agent: Mitsubishi Heavy Industries, Ltd.

20120009643 - Integrated system for hydrogen and methane production from industial organic wastes and biomass: The present invention provides a system that has been devised to overcome the two most important limitations for sustained biological hydrogen production, namely contamination of the microbial hydrogen-producing cultures with methane-producing cultures necessitating frequent re-start-up and/or other methanogenic bacteria inactivation techniques, and the low bacterial yield of hydrogen-producers culminating in... Agent: The University Of Western Ontario

20120009644 - Tissue implants for implantation and methods for preparing the same: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material with water or a hypotonic solution to lyse native cells of the tissue material, treating the tissue material in a nuclease-containing... Agent: Cryolife, Inc.

20120009645 - Culture of pluripotent and multipotent cells on microcarriers: A method is disclosed for culturing pluripotent or multipotent cells in vitro, the method comprising attaching pluripotent or multipotent cells to a plurality of microcarriers to form microcarrier-cell complexes, and culturing the microcarrier-cell complexes in suspension culture in the presence of a ROCK inhibitor.... Agent: Agency For Science, Technology, And Research

20120009646 - Chemically modified carbonic anhydrases useful in carbon capture systems: The present disclosure relates to chemically modified carbonic anhydrase polypeptides and soluble compositions, homogenous liquid formulations comprising them. The chemically modified carbonic anhydrase polypeptides have improved properties relative to the same carbonic anhydrase polypeptide that is not chemically modified including the improved properties of increased activity and/or stability in the... Agent: Codexis, Inc.

20120009647 - Thermostable luciferases and methods of production: Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases, are disclosed. Methods of producing the luciferases include recursive mutagenesis. The luciferases are used in conventional methods, some employing kits.... Agent:

20120009648 - Dna polymerase lambda and uses thereof: The present invention relates to the identification and isolation of a DNA polymerase and uses of this polymerase. In particular, the present invention describes the nucleotide sequence of the human gene for DNA polymerase lambda (Pol λ), the amino acid sequence of Pol λ, and the amino acid sequence of... Agent: Consejo Superior De Investigaciones Cientificas

20120009649 - Synthesis of tagged nucleic acids: The present invention relates generally to methods, compositions and kits for synthesizing sense RNA molecules from one or more RNA molecules of interest in a sample. In exemplary embodiments, the methods use a terminal tagging oligoribonucleotide (rTTO) to join a DNA sequence tag to the 3′-termini of first-strand cDNA molecules.... Agent: Cellscript, Inc.

20120009650 - Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom: Compositions and methods for preparing plasminogen, in particular recombinant plasminogen, and compositions and methods of utilizing same for preparing plasmin are provided.... Agent: Talecris Biotherapeutics, Inc.

20120009651 - Production of thermolysin and variants thereof and use in liquid detergents: The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin... Agent: Danisco US Inc.

20120009652 - Highly stable beta-class carbonic anhydrases useful in carbon capture systems: The present disclosure relates to β-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides formulations and uses of the polypeptides for accelerating the absorption of carbon dioxide from a gas stream into... Agent: Codexis, Inc.

20120009653 - Highly stable beta-class carbonic anhydrases useful in carbon capture systems: The present disclosure relates to β-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides formulations and uses of the polypeptides for accelerating the absorption of carbon dioxide from a gas stream into... Agent: Codexis, Inc.

20120009654 - Highly stable beta-class carbonic anhydrases useful in carbon capture systems: The present invention relates to monoparamunity inducers based on paramunizing viruses or viral components of a myxomavirus strain from rabbits with typically generalizing disease, to a method for the production thereof and to the use thereof as medicaments for the regulatory optimization of the paramunizing activities for the prophylaxis and... Agent:

20120009655 - Method for breaking the cell walls of microalgae: A method for breaking the cell walls of microalgae includes cultivating microbes in a cultivating liquid, adding microalgae into the cultivating liquid to mix with the microbes, releasing a hydrolysis ferment from the microbes, hydrolyzing cell walls of the microalgae by the hydrolysis ferment of the microbes to decompose the... Agent:

20120009656 - Methods and compositions for the recombinant biosynthesis of n-alkanes: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.... Agent: Joule Unlimited Technologies, Inc.

20120009657 - Novel fusion carbonic anhydrase/cellulose binding polypeptide encoded by a novel hybrid gene, and method of creating and using the same: The invention relates a novel hybrid carbonic anhydrase catalyst with the potential to contribute significantly to meeting targeted reductions in greenhouse gas emissions. In a preferred embodiment of the present invention at least a portion of a cellulose binding domain (CBD) of a protein is fused to another protein, carbonic... Agent:

20120009659 - Enzymatic removal of steryl glycosides in fatty acid alkyl esters: The present invention relates to a process of reducing the content of steryl glycoside in a bio-diesel composition which comprises a step of contacting the composition with an enzyme being capable of acylating the steryl glycoside.... Agent: Novozymes A/s

20120009658 - Method and systems for enhancing oil recovery from ethanol production byproducts: Methods and related systems efficiently and effectively recover a significant amount of valuable, useable oil from byproducts formed during a dry milling process used for producing ethanol. The method may include forming a concentrate from the byproduct and recovering oil from the concentrate. The step of forming the concentrate may... Agent: Gs Cleantech Corporation

20120009660 - Method of ash removal from a biomass: Disclosed herein is a process of reducing the ash content of a biomass feedstock or a biomass fraction. Embodiments include a process of reducing the ash content of a biomass feedstock or of a biomass fraction comprising: providing a biomass or biomass fraction; adding alcohol and acid to the biomass... Agent: Pa, LLC

20120009661 - Process for producing cellulose gel dispersion: A cellulosic material is oxidized with an oxidizing agent in the presence of (1) an N-oxyl compound and (2) a bromide, an iodide or a mixture thereof. The resulting material is subjected to defibration and dispersion treatment to prepare a cellulose nanofiber dispersion liquid. The dispersion liquid thus obtained is... Agent:

20120009662 - Method of fabricating microfluidic systems: A method of fabricating a microfluidic system having microfluidic channels on a surface of a hydrophilic substrate, the method including the steps of: hydrophobizing the substrate surface; locating a mask defining the substrate surface, the mask having open areas defining the periphery of the microfluidic channels; and applying an irradiation... Agent: Monash University

20120009663 - Nucleic acid amplification using microfludic devices: The present invention provides microfluidic devices and methods using the same in various types of thermal cycling reactions. Certain devices include a rotary microfluidic channel and a plurality of temperature regions at different locations along the rotary microfluidic channel at which temperature is regulated. Solution can be repeatedly passed through... Agent: California Institute Of Technology

20120009664 - Fermenter for biogas plants, comprising a submersible motor-driven stirrer vertically adjustable by means of a motor: A fermenter for biogas plants, including a submersible motor-driven stirrer that can be vertically adjusted by means of a motor. During operation of the biogas plant, the fermenter is filled, to a level, with substrate that is to be fermented, and the agitator blades of the submersible motor-driven stirrer are... Agent:

20120009666 - Method and apparatus for antigen retrieval process: The invention provides a method for antigen retrieval of a formaldehyde-fixed tissue sample comprising incubating a formaldehyde-fixed tissue sample in a first antigen retrieval solution at a temperature of greater than 90° C., transferring the tissue sample to a second antigen retrieval solution, and incubating the tissue sample in the... Agent: General Electric Company

20120009665 - Methods of producing multi-layered microfluidic devices: Microfluidic devices are prepared by providing a substrate material having a solid adhesive thin sheet, printing solid ink on the substrate using a conventional printer, selectively etching the substrate using a wax masking layer to obtain a desired pattern, removing the masking layer from the substrate, aligning and bonding together... Agent: Xerox Corporation

20120009667 - Apparatus and method for analyzing fluid sample: The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection... Agent:

20120009668 - Biogas capture and/or collection system: A biogas capture and/or collection system is provided and comprises one or more biogas capture and/or collection units (BCCU) that capture and/or collect biogas generated in one or more biogas generating chambers (BGC). The BCCUs maybe tubular conduits operatively linked to the BGCs or canisters removably linked with the BGCs... Agent: Clearford Industries Inc.

20120009669 - Bifunctional compound with monosaccharide and n2s2 ligand, and preparation and use thereof: A bifunctional compound with a monosaccharide and a N2S2 ligand, and more particularly, a bifunctional compound with a N2S2 ligand and aminohexylacetyl galactosamine (ah-GalNAc4) is provided. A method for preparing the bifunctional compound with a monosaccharide and a N2S2 ligand is also provided, including activating a carboxyl group in an... Agent: Institute Of Nuclear Energy Research Atomic Energy Council, Executive Yuan

20120009671 - System and method for microfluidic cell culture: Microfluidic devices and methods for perfusing a cell with perfusion fluid are provided herein, wherein the gravitational forces acting on the cell to keep the cell at or near a retainer or a retaining position exceed the hydrodynamic forces acting on the cell to move it toward an outlet.... Agent:

20120009670 - Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least... Agent: Bayer Pharmaceuticals Corporation

20120009672 - Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype and cells that express a hepatic sinusoidal endothelial phenotype. The invention is also directed to cells produced by the methods of the invention. The cells... Agent: Katholieke Universitiet Leuven

20120009673 - Mesenchymal stem cells for the treatment of cns diseases: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and... Agent: Ramot At Tel-aviv University Ltd.

20120009675 - Methods of producing pancreatic hormones: Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells being competent to further differentiate into hormone-expressing cells capable of secreting at least one pancreatic hormone in response to a physiological signal, and then,... Agent:

20120009674 - Use of a gsk-3 inhibitor to maintain potency of cultured cells: The present invention is directed to the culture of non-embryonic cells, that can differentiate into cell types of more than one embryonic lineage, in culture under conditions that maintain differentiation capacity during expansion; more particularly, culturing non-embryonic cells in the presence of at least one GKS-3 inhibitor, such as BIO.... Agent: Abt Holding Company

20120009676 - Generation of induced pluripotent stem cells from small volumes of peripheral blood: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel... Agent:

20120009677 - Method for producing a bio-artificial transplant: The invention relates to a method for producing a bio-artificial transplant from biological tissue provided for transplantation, which has cells that are compatible with the recipient applied thereto. According to the invention, a controlled tissue generation is carried out in-vitro, during which selected cells that are capable of remodelling the... Agent:

20120009680 - Cancerous disease modifying antibodies: The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be... Agent: Hoffmann-la Roche Inc.

20120009678 - Immunotherapy targeting intracellular pathogens: The present invention relates to the use of immunogenic peptides comprising a T-cell epitope derived from an intracellular pathogen-associated antigen and a redox motif such as C-(X)2-[CST] or [CST]-(X)2-C in the prevention and/or treatment of infection with an intracellular pathogen and in the manufacture of medicaments therefore.... Agent:

20120009679 - Tissue implants for implantation and methods for preparing the same: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial.... Agent: Cryolife, Inc.

20120009681 - Platform of dendritic cell (dc)-based vaccination: The present invention discloses novel dendritic cell maturation-inducing cytokine cocktails, and methods for inducting type-1 polarized dendritic cells in serum-free conditions which enhance the desirable properties of DC1s generated in serum-supplemented cultures. The invention further discloses methods and systems using IFNγ and other ligands of the IFNγ receptor, in combination... Agent:

20120009682 - Method for selecting a high expression recombinant cell line: The present invention relates to a method of selecting high producer clones by using an expression vector, the expression vector comprising: (i) a gene expression cassette comprising a selectable marker gene to which polyA has been inoperably linked; and (ii) a gene expression cassette which encodes a recombinant protein of... Agent: Celltrion Inc.

  
01/05/2012 > 120 patent applications in 65 patent subcategories. recently filed with US Patent Office

20120003623 - Nonlinear model predictive control of a batch reaction system: The present invention provides novel techniques for controlling batch reaction processes. In particular, a parametric hybrid model may be used to parameterize inputs and outputs of batch reaction processes. The parametric hybrid model may include an empirical model, a parameter model, and a dynamic model. Critical quality parameters, which are... Agent: Rockwell Automation Technologies, Inc.

20120003625 - Methods and kits for detecting an infectious agent: The present invention provides methods and kits for determining the presence, absence, or level of an infectious agent in a sample. Specifically, the present invention provides methods and kits for detecting or quantifying certain target polynucleotides of the infectious agent. In certain embodiments, the present invention provides for such detection... Agent: Diacarta, LLC

20120003628 - Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions: Methods for aiding in the diagnosis of disorders including, but not limited to, PDDs (Pervasive Development Disorders), Dysautonomic disorders, Parkinson's disease and SIDS (Sudden Infant Death Syndrome). In one aspect, a diagnosis method comprises analyzing a stool sample of an individual for the presence of a biological marker (or marker... Agent: Curemark LLC

20120003627 - Portable fluorescence reader device: The present invention describes a device for performing a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The device also includes a compatible slide comprising sample wells. The device detects emitted fluorescence signal through a camera and optics assembly that is... Agent:

20120003626 - Sampling devices and methods for concentrating microorganisms: The present disclosure describes methods for concentrating microorganisms with concentration agents in a sampling device and the sampling device described herein. More specifically, methods for concentrating microorganisms from large volume samples with concentration agents in a sampling device can provide for rapid, low cost, simple (involving no complex equipment or... Agent:

20120003624 - Standardized method and kit for the quantification of hepatitis a virus: The present invention provides a standardized method and a kit for an accurate quantification of HAV in clinical and food samples. The general approach is based on the use of several controls to measure the efficiency of those critical steps of the quantification: the nucleic acids extraction and the RT-PCR... Agent: Universidad De Barcelona

20120003631 - Instrument for cassette for sample preparation: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system... Agent: Genturadx, Inc.

20120003630 - Modular nucleic acid-based circuits for counters, binary operations, memory, and logic: We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for encoding memory in cells and cellular systems. Our designs are easily extended to compute to high numbers, by utilizing the >100 known... Agent: Trustees Of Boston University

20120003629 - Biological control of nanoparticle nucleation, shape and crystal phase: The present invention includes compositions and methods for selective binding of amino acid oligomers to semiconductor and elemental carbon-containing materials. One form of the present invention is a method for controlling the particle size of the semiconductor or elemental carbon-containing material by interacting an amino acid oligomer that specifically binds... Agent: Board Of Regents, The University Of Texas System

20120003632 - fret-probes and use thereof: This invention relates to the detection of among others tumor-specific fusion proteins and protein interactions. Provided is a set of at least a first and a second molecular probe, each probe provided with a dye wherein said dyes together allow energy transfer, each probe additionally provided with a reactive group... Agent: Life Science Patents

20120003639 - Cancer biomarkers and methods of use thereof: Embodiments are provided for characterizing a biological sample. In some embodiments, one can estimate the risk that a subject with ductal carcinoma in situ will have a subsequent DCIS event and/or invasive cancers.... Agent: The Regents Of The University Of California

20120003645 - Compositions, methods and kits for nucleic acid synthesis and amplification: The present invention is directed to compositions, methods and kits useful for the synthesis of nucleic acid molecules. More specifically, compositions, methods and kits are provided for the amplification of nucleic acid molecules in a one-step RT-PCR procedure comprising one or more agents used to increase tolerance to PCR inhibitors.... Agent: Life Technologies Corporation

20120003635 - Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing: Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome... Agent:

20120003636 - Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing: Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome... Agent: The Chinese University Of Hong Kong

20120003637 - Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing: Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome... Agent: The Chinese University Of Hong Kong

20120003643 - Enrichment and identification of fetal cells in maternal blood and ligands for such use: The present invention relates to enrichment and/or identification of fetal cells of a maternal blood sample using fetal cell specific ligands and/or fetal cell specific hybridization probes. Enriched or identified fetal cells may be subjected to steps of detection or diagnosis, wherefore the present invention enables non-invasive prenatal diagnostics.... Agent: Fcmb Aps

20120003641 - Genetic polymorphisms in age-related macular degeneration: Methods for determining whether a patient is at increased risk of developing wet AMD or whether a patient has an increased likelihood of benefiting from treatment with a high-affinity anti-VEGF antibody.... Agent:

20120003647 - Genetic polymorphisms in the prostate-specific antigen gene promoter: The present invention includes methods of identifying a subject at risk for increased cellular PSA production and/or prostate cancer by detecting the presence or absence of a genetic polymorphism in the prostate specific antigen gene.... Agent:

20120003634 - Identification of source of dna samples: The present disclosure relates to methodology for fast and cost-effective identification of the source of DNA samples. DNA samples obtained from unknown or unrecognized tissues or cell types are analyzed according to the methodology described herein, yielding an identification of the tissue and/or cell type source. Identification is based on... Agent: Nucleix

20120003638 - Kit for high throughput mutation screening methods: One example embodiment includes a kit to execute a method of simultaneously screening for genetic mutations in different genes in a multitude of samples. The kit includes an antisense deoxyribonucleic acid (DNA) probe, where the antisense DNA probe will be mixed with a strand of a ribonucleic acid (RNA) to... Agent:

20120003650 - Marker for prenatal diagnosis and monitoring: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which... Agent: The Chinese University Of Hong Kong

20120003633 - Means and methods for investigating nucleic acid sequences: The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid.... Agent:

20120003646 - Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals: Apparatus and method for detecting analyte in a reaction mixture comprising an internal control. The invention is illustrated using amplification and detection of nucleic acids, where the amplification reaction comprises an exogenous internal control. Magnitude of the detection signal serves as the variable for identifying invalid trials, identifying valid trials... Agent: Gen-probe Incorporated

20120003644 - Methods and kits for determining predisposition to develop kidney diseases: Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on Trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild... Agent: Rappaport Family Institute For Research In The Medical Sciences

20120003649 - Methods for assessing risk of alzheimer's disease in a patient: Disclosed are methods for diagnosis or prognosis of Alzheimer's disease in a patient. The methods may include assessing whether a patient has Alzheimer's disease or assessing a patient's risk for developing Alzheimer's disease. The methods typically include determining, either directly or indirectly, whether the patient has mutations, such as single... Agent: Wisconsin Alumni Research Foundation

20120003640 - Mrna ratios in urinary sediments and/or urine as a prognostic and/or theranostic marker for prostate cancer: Described herein are methods and kits for prognosis of prostate cancer in a subject. The methods comprises: (a) determining the ratio of PCA3 and of a prostate-specific marker expression in a urine sample and (b) correlating the value of the PCA3/prostate-specific marker ratio with the aggressiveness and mortality risk of... Agent:

20120003642 - Oligonucleotides and methods for determining susceptibility to soft tissue injuries: A method of determining in a subject a predisposition to, or increased risk for, developing a tendon, ligament, or other soft tissue injury or pathology, the method comprising the step of screening the subject for the presence of at least one poly-morphism in at least one gene family selected from... Agent: University Of Cape Town

20120003648 - Signal multiplexing and signal amplification: Disclosed are methods, compositions and kits for amplifying signals for detecting the presence, quantity and/or sequence of nucleic acids and proteins, as well as methods, compositions and kits for increasing the number of such targets simultaneously detectable in a sample. Detection may be, for instance, in vivo, in cellulo or... Agent: Affymetrix, Inc.

20120003651 - Tagged oligonucleotides and their use in nucleic acid amplification methods: The present invention provides nucleic acid amplification methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplification reaction and/or that may be present in the environment in which an... Agent: Gen-probe Incorporated

20120003653 - Compositions and methods for detecting mutations in jak2 nucleic acid: The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides compositions and methods useful for diagnosing hematopoietic diseases including, for example, myeloproliferative diseases. The invention also provides compositions and methods useful for determining a prognosis of an individual... Agent: Quest Diagnostics Investments Incorporated

20120003660 - Diagnosis or prognosis of breast cancer based on expression level of thioredoxin-1: The present disclosure relates to a diagnostic marker for breast cancer, having thioredoxin-1 as an active ingredient, and to a diagnostic kit for breast cancer using same. The thioredoxin-1 is overexpressed in human breast cancer tissue so as to enable the early diagnosis of breast cancer or the early prediction... Agent: Paichai University Industry-academic Cooperation Foundation

20120003652 - Essential genes encoding conserved metabolic pathway function in autotrophic solventogenic clostridial species: Essential genes coding for the metabolic pathway of solventogenic autotrophic Clostridia were sequenced, and functionality was confirmed. The present invention utilizes a comparative inter-species approach to develop the minimum set of essential genes for metabolic function and estimate productivity in species of suspected solventogenic capability.... Agent: Coskata, Inc.

20120003655 - Identification of neuroprotective agents using pro-inflammatory human glial cells: Provided herein are methods for, inter alia, identifying new therapeutic agents using human cell-based models.... Agent: The Salk Institute For Biological Studies

20120003658 - Microfluidic droplet queuing network: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from... Agent: Stokes Bio Limited

20120003656 - Sample preparation for in situ nucleic acid analysis, methods and compositions therefor: Sample preparation processes for in situ RNA or DNA analysis, methods and compositions therefor are provided. Processes provided herein allow DNA or RNA analysis to be carried out in the same tube or on an aliquot of the prepared sample without centrifugation or extraction. The preparation process can be carried... Agent: Life Technologies Corporation

20120003659 - Strobo thin film chemical analysis apparatus and assay method using the same: Disclosed are a strobo thin film chemical analysis apparatus based on the stroboscope principle and an assay method using the same. The strobo thin film chemical analysis apparatus is suitable for real-time analysis for a rotatable bio disc such as a lab on a disc integrated with bio chips such... Agent: Samsung Electronics Co., Ltd.

20120003657 - Targeted sequencing library preparation by genomic dna circularization: Certain embodiments provide a method of sequencing that comprises: a) contacting, under hybridization conditions, a target genomic fragment with: i. a vector oligonucleotide comprising a binding site for a sequencing primer; and ii. a splint oligonucleotide that hybridizes to the vector oligonucleotide and to the nucleotide sequences at the ends... Agent:

20120003654 - Magnetic lysis method and device: A method for lysing cells is disclosed. The method includes stirring cells with a magnetic stir element in the presence of a plurality of cell lysis beads at a speed sufficient to lyse the cells. Also disclosed is a device for lysing cells. The device includes a container having a... Agent:

20120003661 - Methods and devices for the selective detection of microorganisms: Methods and devices are provided for the rapid and specific detection of target microorganisms, cells, and the like. In one embodiment, the methods involve contacting a target microorganism (e.g., in a sample) with a permeabilization reagent that selectively permeabilizes or lyses the microorganism; contacting the selectively permeabilized microorganism with a... Agent: C3 Jian, Inc.

20120003662 - Methods and kits for detecting mastitis: Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of... Agent: University Of Medicine And Dentistry Of New Jersey

20120003663 - Method of rapidly quantifying hydroxymethylated dna: This invention is related to a method for rapidly quantifying hydroxymethylated DNA by binding DNA to a plastic carrier followed by immunodetection of 5-hydroxymethylcytosine or a hydroxymethylcytosine structure that is marker of DNA hydroxymethylation.... Agent:

20120003664 - Method for evaluating pre-treatment: The present invention relates to methods for evaluating tissue pre-treatment such as ischemic time, fixation time and alcohol time in an immunohistochemical assay by using one or more internal controls. Said internal controls may be biomarker specific or tissue specific. Also included are uses and kits comprising said internal controls.... Agent:

20120003670 - Methods and kits for measuring von willebrand factor: Methods and kits for measuring levels of von Willebrand factor function in a sample without using a platelet aggregation agonist, such as ristocetin, comprising recombinant glycoprotein Ibα having at least two of a G233V, D235Y and M239V mutations and an agent to detect a complex between the recombinant glycoprotein Ibα... Agent:

20120003665 - Dissolved protein arthritis markers: Methods and kits for diagnosing arthritis are provided. The methods may involve detection of 14-3-3 eta or gamma proteins in a sera or synovial fluid sample.... Agent:

20120003666 - Method of detecting target substance: Provided is a method of measuring a being state of a target substance at unknown concentration contained in a sample. The method includes identifying a kind of a target substance when one kind of target substance is contained in a sample and determining a concentration ratio when plural kinds of... Agent: Canon Kabushiki Kaisha

20120003667 - Electrophoretic tag-based in vitro assay to quantify dimerization of p66 and p51 sub-units of hiv-1 reverse transcriptase (rt): Methods for measuring hetero- and homodimerization of HIV reverse transcriptase (HIV RT) are provided using pairs of tagged probes and cleaving probes. The methods can be used, for example, to screen for modulators of HIV RT dimerization. Also provided are methods of determining whether a compound modulates HIV RT. Further... Agent:

20120003668 - High resolution complex structure and allosteric effects of low molecular weight activators on the protein kinase pdk1: The present invention provides a mutant form of a protein kinase its production and its use for identifying compounds that bind to the PIF-binding pocket allosteric site of the protein kinase.... Agent: Universitaet Des Saarlandes

20120003669 - Immunohistochemical staining method and immunohistochemical staining apparatus: An immunohistochemical staining apparatus for carrying out immunohistochemical staining includes a sample chamber (1) in which a primary sample (s1) comprised of a tissue specimen (t) to which a primary antibody (Ig1) is applied is disposed between a sample-side electrode (11) and an opposed electrode (12). The sample chamber (1)... Agent:

20120003674 - Chloral hydrate detection: The invention relates to an immunoassay method and kit for the indirect detection of chloral hydrate. The invention is underpinned by a novel immunogen that produces an antibody that is specific for the chloral hydrate metabolite trichloroethanol glucuronide. Detection and quantification of trichloroethanol glucuronide has important applications in clinical toxicology,... Agent: Randox Laboratories Limited

20120003672 - In vitro-method for the diagnosis, prognosis, monitoring and therapy follow-up of disorders associated with the metabolic syndrome, a cardiovascular disease and/or insulin resistance: The present invention relates to an in vitro-method for diagnosis, prognosis and/or monitoring/therapy follow-up of a disorder of the metabolic system and/or cardiovascular system and/or insulin resistance in a subject, comprising the determination of the relative level of one or more cardiovascular markers in a sample of a subject and... Agent: B.r.a.h.m.s Gmbh

20120003671 - Methods for antibody engineering: The invention provides a method for identifying positions of an antibody that can be modified without significantly reducing the binding activity of the antibody. In many embodiments, the method involves identifying a substitutable position in a parent antibody by comparing its amino acid sequence to the amino acid sequences of... Agent:

20120003673 - Screening method, composition containing substance selected by the screening method, and binding substance: Disclosed is a screening method which can select a substance having an influence on the binding between thioredoxin and MIF. The screening method is characterized in that a test substance capable of enhancing the binding between a polypeptide belonging to the thioredoxin family and a macrophage migration inhibitory factor is... Agent: Redox Bioscience, Inc.

20120003675 - Method for preparing small volume reaction containers: Engineered reaction containers that can be physically and chemically defined to control the flux of molecules of different sizes and charge are disclosed. Methods for constructing small volume reaction containers through a combination of etching and deposition are also disclosed. The methods allow for the fabrication of multiple devices that... Agent:

20120003676 - Mass spectrometry assay for thiopurine-s-methyl transferase activity and products generated thereby: Methods are described for measuring the amount of a methylation TPMT enzyme product in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying 6-MMP or isotopically labeled 6-MMP in a test sample utilizing mass spectrometric techniques and for using such methods to determine the activity of... Agent: Quest Diagnostics Investments Incorporated

20120003677 - Identification of tissue for debridement: Provided are methods of determining whether a cell in a tissue site is viable or nonviable. Also provided are methods of debriding tissue from a tissue site. Further provided are kits comprising a compound that distinguishes between viable and nonviable cells and instructions for using the compound on a tissue... Agent:

20120003678 - Novel fructosyl peptide oxidase: o

20120003680 - Assembly of absolutely quantified peptide and phosphopeptide solutions via element mass spectrometry: The present invention relates generally to the fields of analytics of proteins and peptides. More particularly, the invention concerns generation of an absolutely quantified reference peptide or protein solution via element mass spectrometry. Furthermore, the invention relates to the absolute quantification of phosphopeptides and peptides by the use of an... Agent: Dkfz Deutsches Krebsforschungszentrum, Stiftung Des &#xd5 Ffentlichen Rechts

20120003683 - Cells for indicating the preservation of biological samples: Methods of characterizing the extent to which a biological sample preserved at a very low temperature has been exposed to stress using indicator cells is provided.... Agent: Etablissement Francais De Sang

20120003681 - Ex vivo method for determining potential glp-2 receptor modulations: Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue.... Agent: Nps Pharmaceuticals, Inc.

20120003684 - Method and means for detecting the activity of osteoclasts: The invention relates to a method and means for detecting the resorption activity of osteoclasts, in particular for use in medicine and in bioscience and pharmaceutical research. Previous methods for measuring the resorption activity of osteoclasts in vitro are difficult to quantify, are partially inflexible when used with different donor... Agent: Technische Universitaet Dresden

20120003682 - Microfabricated apparatus for cell based assays: Apparatus and methods are provided for performing cell growth and cell based assays in a liquid medium. The apparatus comprises a base plate supporting a plurality of micro-channel elements, each micro-channel element comprising a cell growth chamber, an inlet channel and an outlet channel, a cover plate positioned over the... Agent: Gyros Patent Ab

20120003679 - Sensor module, tissue processor, and method for operating a tissue processor: A sensor module (38, 40, 42) for a tissue processor (20) has a thermal sensor (66) for measuring a temperature of a container (30, 32, 34) of the tissue processor (20), and further has a position sensor for detecting a working position of the container (30, 32, 34).... Agent: Leica Biosystems Nussloch Gmbh

20120003686 - Culture plate holder: The present disclosure describes holder devices, testing kits that include the holder devices, and methods for using the holder devices to allow a user to dispense an aqueous test sample from a sampling device onto a culture plate device having a cover sheet, whereby the cover sheet is supported in... Agent:

20120003685 - Diagnostic composition and article for monitoring intravaginal infections: The present invention provides a non-toxic diagnostic composition for intravaginal monitoring of vaginal infections. The present invention further provides a diagnostic article for intravaginal monitoring of vaginal infections with the article including an absorbent material for absorbing vaginal secretions and a composition suitable for identification of the pH or the... Agent:

20120003687 - Methods for counting cells: The invention features methods of quantifying cells in a sample by lysing the cells followed by the measurement of at least one intracellular component. Methods of the invention are especially useful for quantifying small numbers of cells, e.g., over a large surface area or volume compared to the cell size.... Agent:

20120003688 - Compositions and methods for using nadh oxidases: The present disclosure relates generally to bacterial NADH oxidases and, more particularly, to novel NADH oxidases obtained from Lactobacillus plantarum, and derivatives thereof that demonstrate enzymatic activity for NADH, NADPH, or both NADH and NADPH. The compositions comprising an NADH oxidase obtained from L. plantarum or derivatives thereof include: isolated... Agent: Georgia Tech Research Corporation

20120003689 - Hydrophobic magnetic particles: A process for making a particulate material comprising mesoporous particles having granules of a metal containing species in at least some of the pores thereof, said process comprising: allowing a compound of the metal to enter pores of hydrophobic mesoporous particles, said compound being thermally decomposable at a decomposition temperature... Agent: Agency For Science, Technology And Research

20120003690 - Enzymatic generation of functional lipids from cereals or cereal bi-streams: The present invention relates to the modification of lipids in lipid-containing plant material, such as cereal bran for the generation of functional lipids. The present invention further relates to the preparation of compositions comprising such functional lipids as well as the use of these compositions comprising functional lipids and other... Agent: Danisco A/s

20120003692 - Method for producing alpha-l-aspartyl-l-phenylalanine-beta-ester and method for producing alpha-l-aspartyl-l-phenylalanine-alpha-methyl ester: A method of producing an α-L-aspartyl-L-phenylalanine-β-ester by forming the α-L-aspartyl-L-phenylalanine-β-ester from L-aspartic acid-α,β-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to selectively link L-phenylalanine to an α-ester site of the L-aspartic acid-α,β-diester through a peptide bond.... Agent: Ajinomoto Co., Inc.

20120003691 - Method of isolation and purification of trypsin from pronase protease and use thereof: The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease mixture in a single affinity chromatography step and uses of the purified SGT.... Agent: Baxter Healthcare S.a.

20120003693 - Novel peptide-forming enzyme gene: DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a dipeptide includes producing a dipeptide from a carboxy component and an amine component by using a culture of a microbe... Agent: Ajinomoto Co., Inc.

20120003694 - Bioengineered protein pores: A mutant Escherichia coli β-barrel monomeric protein pore bioengineered to remove a lumen-occluding domain and modify some of its extracellular domains. The modified protein, FhuA Δ/CΔ4L, forms a highly conductive pore as compared to other known pores and is capable of sensing large polypeptides and discriminating between modified protein analytes.... Agent: Syracuse University

20120003695 - Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris: Lower eukaryotic cells such as Pichia pastoris that normally cannot use galactose as a carbon source but which have been genetically engineered according to the methods herein to use galactose as a sole source of carbon are described. The cells are genetically engineered to express several of the enzymes comprising... Agent:

20120003696 - Diagnostic methods for diseases by screening for hepcidin in human or animal tissues, blood or body fluids, monoclonal antibodies specific to human hepcidin and associated uses therefor: The present invention concerns antibodies specific for the C-terminus of human hepcidin, and related methods and kits for diagnosing and/or treating a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with... Agent: Drg International, Inc.

20120003697 - High affinity antibodies to human il-6 receptor: A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an... Agent: Regeneron Pharmaceuticals, Inc.

20120003698 - Linear amplification of short nucleic acids: The present teachings provide novel methods for amplifying short nucleic acids. In some embodiments, the present teachings provide novel methods for linearly amplifying a collection of micro RNAs by using temperature cycling during a reverse transcription reaction. The cycling can comprise at least 20 cycles of an annealing temperature segment... Agent: Life Technologies Corporation

20120003699 - Separtion of tagged fragments: Methods of separating tagged nucleic acid fragments from populations of fragments are provided. The fragments are produced from a population of tagged nucleic acids. In some cases, the population of tagged nucleic acids comprises a population of clonal nucleic acids.... Agent: Pacific Biosciences Of California

20120003700 - Thermostable alpha-amylases: t

20120003703 - Cellobiohydrolase variants: The invention relates to recombinant expression of variant forms of C1 CBH1a and homologs thereof, having improved thermostability, low-pH tolerance, specific activity and other desirable properties. Also provided are methods for producing ethanol and other valuable organic compounds by combining cellobiohydrolase variants with cellulosic materials.... Agent: Codexis, Inc.

20120003701 - Heterologous expression of termite cellulases yeast: The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast Saccharomyces cerevisiae. The cellulases can also be co-expressed in host cells with other cellulases. The expression in such host cells... Agent: Mascoma Corporation

20120003702 - Process for producing saccharified solution of lignocellulosic biomass: A process for producing a saccharified solution, by which xylose can be produced at a high yield from lignocellulosic biomass, is provided. The saccharification is carried out by adding a saccharifying enzyme to a pretreated material for saccharification of the lignocellulosic biomass. As the saccharifying enzyme is added a mixture... Agent: Honda Motor Co., Ltd.

20120003704 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent: Xyleco, Inc.

20120003705 - Biological clean fuel processing systems and methods: Methods and systems to achieve clean fuel processing systems in which carbon dioxide emissions (1) from fossil fuel consumption sources (2) may be processed in at least one processing reactor (4) containing a plurality of chemoautotrophic bacteria (5) which can convert the carbon dioxide emissions into biomass (6) which may... Agent: The University Of Wyoming Research Corporation D/b/a Western Research Institute

20120003706 - Process for converting a co and co2 feed gas stream to liquid products by fermentation: A process converts a gas input stream comprising CO, CO2, and H2 by contact with fermentation liquid into a liquid product that controls the concentration of CO and CO2 in the fermentation vessel. The process charges the feed gas stream and a recycle gas stream to the fermentation vessel and... Agent:

20120003707 - Method for injecting a feed gas stream into a vertically extended column of liquid: A process for conversion of syngas to liquid products that serve as surface acting agents uses the gas stream at a relatively low pressure to eliminate the use of a compressor. The process uses a liquid stream as the primary energy input to a gas injector that intensely mixes gas... Agent:

20120003708 - Methods of producing c4 dicarboxylic acids: Methods of producing C4 dicarboxylic acids are disclosed. Nucleotide sequences encoding pyruvate carboxylase and uses of such nucleotide sequences in the production of C4 dicarboxylic acids are further disclosed.... Agent: Archer Daniels Midland Company

20120003709 - Method and system for cell and tissue cultivation: A cell cultivating platform includes a substrate having a surface, at least one actuator moveable relative to the substrate, and a deformable material layer positioned above at least a portion of the supporting surface and the at least one actuator. The deformable material layer positioned opposite the substrate surface includes... Agent: Empire Technology Development LLC.

20120003710 - Isolation of biomolecules from biological samples: Nanoparticles for use in the collection, concentration, isolation and storage of biomolecules from biological samples are provided. More specifically, nanoparticles used to isolate biomolecules, including nucleic acids and proteins, cells, cell fragments, bacteria, and viruses from biological samples such as urine, cerebrospinal fluid (CSF), mouthwash samples, and amniotic fluid are... Agent:

20120003711 - Device for capturing circulating cells: The present invention provides devices and methods for capturing rare cells. The devices and methods described herein can be used to facilitate the diagnosis and monitoring of metastatic cancers.... Agent: The Regents Of The University Of California

20120003712 - Method for preparing a site-specific physiologically active polypeptide conjugate: The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a non-peptidyl polymer in the presence of an alcohol at a specific pH, which can be desirably employed in the development of long acting formulations... Agent: Hanmi Holdings Co., Ltd.

20120003714 - Blends containing proteases: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysis. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly... Agent:

20120003713 - Polymerase enhancing factor (pef) extracts pef protein complexes isolated pef proteins and methods for purifying and identifying: The invention provides novel extracts, proteins, and complexes that improve the polymerization activity of nucleic acid polymerases. Included within the aspects of the invention are methods for identifying compositions with a polymerase enhancing activity, methods for purifying and using these compositions, and specific extracts, proteins, and complexes that function to... Agent: Agilent Technologies, Inc.

20120003715 - Process for producing recombinant lyosomal using insect larvae: A method for expressing and industrial scale production of recombinant lysosomal enzymes utilizing insect larva including the steps of infecting an insect larva population of the species Spodoptera littoralis via a recombinant baculovirus liquid suspension which permits the expression of at least one gene coding for a protein of interest,... Agent: Bioorganic Research And Services S.l.

20120003716 - Method for producing lipase, transformed yarrowia lipolytica cell capable of producing said lipase and their uses: Method for producing Yarrowia lipolytica acid-resistant recombinant lipase utilizing a culture medium without any products of animal origin or non-characterized mixtures such as tryptone, peptone or lactoserum, in addition to its uses. Recombinant strain of Yarrow lipolytica producing an excessive amount of lipase Lip2 referred to as YL-LIP2-6C and filed... Agent: Laboratoires Mayoly Spindler

20120003717 - Streptomyces strain that decomposes proteins recalcitrant to proteolysis: The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and... Agent: Microbial Chemistry Research Foundation

20120003718 - Protease comprising one or more combinable mutations: The present invention provides engineered protease variants. In particular, the protease variants comprise combinable mutations at selected surface positions that affect the charge and/or hydrophobicity of the enzyme to enhance at least one desired property of the resulting variant enzyme in a chosen application. Compositions comprising the protease variants, and... Agent: Danisco US Inc.

20120003719 - Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis c virus lacking the hypervariable region 1 (hvr1): The present inventors used the previously developed H77/JFH1T27OOC,A4O8OT (1a/2a), J4/JFH1T2996C,A4827T,ΔHVRI (1b/2a), J6/JFH1ΔHVRI (2a/2a), J8/JFH1ΔHVRI (2b/2a), S52/JFH1T27i8G,τ7i6oc (3a/2a), SA13/JFH1C34O5G,A3696G (5a/2a) and HK6a/JFH1T1389c,A1590G (6a/2a) constructs for the deletion of Hypervariable Region 1 (HVR1) to construct viable, JFH1 (geno-type 2a) based, genomes. The present inventors serially passaged the viruses in cell culture obtaining... Agent:

20120003720 - Nucleic acid derived from hepatitis c virus and expression vector, transformed cell, and hepatitis c virus particles each prepared by using the same: The present invention provides a nucleic acid comprises a 5′ untranslated region, an NS3 protein coding region, an NS4A protein coding region, an NS4B protein coding region, an NS5A protein coding region, an NS5B protein coding region, and a 3′ untranslated region of a hepatitis C virus genome, wherein the... Agent:

20120003721 - Method for making lactic acid bacteria composition: A method for making at least 2 kg (dry weight) of a lactic acid bacteria composition formulated with from 1% to 50% of ascorbate or ascorbic acid (w/w−dry matter) as antioxidant, wherein the pH is controlled so 3≦pH≦8 during at least the majority of the fermentation process by addition of... Agent:

20120003722 - Carbon dioxide removal systems: A system for removing CO2 from air such as atmospheric air is described that uses a cooling tower, a pseudo-cooling tower, or a wind capture device to provide a large volume of atmospheric air. A CO2 capture apparatus is positioned to contact atmospheric air moving towards or within the cooling... Agent: Coaway LLC

20120003723 - Method for treating and dispersing animal waste: A method of dispersing animal waste includes providing an delivery article for holding a treatment agent, said article constructed and arranged with a source of pressurized gas that forces a treatment agent through an outlet of the delivery article and covers animal waste such that the physical pressure of liquid... Agent: Hollywood Ventures, LLC

20120003724 - Process and reactor system for depolymerization of polymeric biomass: The present invention provides a continuous process for saccharification of cellulose by enzymatic degration without any loss of enzymes and also discloses a bioreactor for performing said process.... Agent: Nagarjuna Energy Private Limited

20120003725 - Microfluidic chip for analysis for fluid sample: Disclosed is a microfluidic chip capable of accurately and quickly detecting presence of a trace amount of a target within a fluid sample. It has a channel structure comprising a sample inlet for feeding a sample therethrough, a first reservoir for primarily storing the sample therein, a second reservoir for... Agent: Digital Bio Technology Co., Ltd.

20120003726 - Apparatus and method for calibration of non-contact thermal sensors: Biochemical assay apparatus uses a container with a sleeve of electrically-conductive material (300) to heat it. The heating is done inside a chamber and a contactless heat sensor (110) such as a thermopile or a bolometer, also inside the chamber, is used to monitor the temperature of the electrically conductive... Agent: Enigma Diagnostics Limited

20120003727 - Immunoassay device for detecting antibodies and antigens: A fourth generation immunoassay device includes first, second, third, and fourth sorbent or bibulous materials defining first, second, third and fourth horizontal flow paths. The first and second flow paths are for migration of first and second conjugates while the third and fourth flow paths are for the migration of... Agent:

20120003731 - Analyzer and method for washing dispenser probe: The analyzer (1) of the present invention comprises: a reading section (23) for storing or obtaining specimen information including a sample type of a specimen, and specimen container information; a liquid level detecting section (51) for detecting a liquid level and/or an interface of the specimen; a dispensing apparatus (5)... Agent: Beckman Coulter, Inc.

20120003729 - Capillary perfused bioreactors with multiple chambers: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor includes a first substrate having a first surface, an opposite second surface and edges. The bioreactor further includes a second substrate having a first surface and an opposite second surface, defining... Agent: Vanderbilt University

20120003730 - Portable sample analyzer cartridge: A sample analyzer cartridge for use at a point of care of a patient such as in a doctor's office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used... Agent: Honeywell International Inc.

20120003728 - Scalable portable sensory and yield expert system for biomass monitoring and production: The invention relates to the field of algae biofuel production, in particular to methods and means of physical action on biological structures of photosynthesing microorganisms, phototrophic algae in particular. The invention can be used for obtaining biofuel from algae, as well as for the pharmaceutical, cosmetic and foodstuff industries. In... Agent:

20120003732 - Microfluidic cell culture systems: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation.... Agent: Cellasic, Inc.

20120003733 - Mixing container comprising a shaft bearing in the upper part: A mixing container includes a flexible container, mixing elements and an upper bearing having a rigid flange. The flange is provided with an insertion passage that fluidically communicates with the inside space on one end and with the outside of the container on the other end. The flange is fixed... Agent: Sartorius Stedim Biotech S.a.

20120003734 - Device for a photochemical process: The invention relates to a device for a photochemical process, such as a photocatalytic and/or a photosynthetic process, especially for the cultivation and production or hydrocultivation of preferably phototrophic micro-organisms. A reactor, especially a bioreactor, is provided, and a reaction medium, for example an aqueous solution or a suspension, is... Agent: Ecoduna Technologie Gmbh

20120003735 - Methods for improving viability and productivity in cell culture: Methods for increasing viability and production of secreted proteins in fed batch eukaryotic cell culture are disclosed.... Agent:

20120003736 - Methods for culturing undifferentiated cells using sustained release compositions: Methods for culturing undifferentiated mammalian cells, such as stem and progenitor cells, are provided. The methods involve incubating the cell in the presence of a sustained release composition containing at least one growth factor, wherein the sustained release composition continuously releases the growth factor(s), and wherein the presence of the... Agent: Regenerative Research Foundation

20120003738 - Method for amplification and functional enhancment of blood derived progenitor cells using a closed culture system: The present invention provides a method for expanding and improving functional capacity of human adult-derived progenitor cells in vitro using a closed culture system. The present invention provides a favorable condition for cell therapy to promote tissue repair and organogenesis via vasculogenesis and angiogenesis in clinical settings. The proposed closed... Agent: University Hospitals Of Cleveland

20120003737 - Multipotent stem cells and uses thereof: The invention provides a quiescent stem cell having the capacity to differentiate into ectoderm, mesoderm and endoderm, and which does not express cell surface markers including MHC class I, MHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105 and CD90. The invention further provides a proliferative stem cell, which... Agent: The Brigham And Women's Hospital, Inc.

20120003739 - Populations of expanded and re-differentiated adult islet beta cells capable of producing insulin and methods of generating same: A population of expanded adult islet beta cells is provided as well as a population of expanded and redifferentiated adult islet beta cells. Methods of generation of the populations of cells are provided.... Agent: Ramot At Tel-aviv University Ltd.

20120003740 - Electroporation apparatus and methods: This document discloses electroporation vessels, electrocompetent cells that have been aliquoted and frozen in electroporation vessels, and a number of other apparatuses, kits, and methods for electroporation. Some embodiments of electroporation vessels described herein may include a pair of opposing walls that are downwardly angled toward one another in a... Agent: Life Technologies Corporation

20120003741 - Hepatitis c virus expressing reporter tagged ns5a protein: The present inventors developed hepatitis C reporter viruses containing Core through NS2 of prototype isolates of all major HCV genotypes and the remaining genes of isolate JFH1, by insertion of reporter genes in domain III of HCV NS5A. The inventors have identified a deletion upstream of the inserted reporter gene... Agent: Hvidovre Hospital

20120003742 - Recombinant virus, escherichia coli retaining the same and a process for production thereof: e

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