|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology December patent applications/inventions, industry category 12/11Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 12/29/2011 > 115 patent applications in 64 patent subcategories.
20110318725 - Cell culture method, cell culture device, method for counting subsject matters to be counted in container and device for counting: An external force is applied to the culture container to carry out at least one of cell aggregate formation control and cell aggregate disintegration control with respect to cells in the culture container, thus culturing the cells. The external force is applied to the culture container by pressing an agitating... Agent: Toyo Seikan Kaisha Ltd.
20110318726 - Predicting coronary artery disease and risk of cardiovascular events: Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines,... Agent:
20110318727 - Genetic marker for detection of human papillomavirus: The invention provides compositions and methods for the differential detection of high risk forms of HPV from a urine sample provided by a patient. Specifically, the invention provides primers and probes that specifically recognize and bind sequences within the E1 gene of HPV. Detection of high risk forms of HPV... Agent:
20110318729 - Rapid bioluminescence detection assay: An assay is provided for detecting the activity of a reporter kinase comprising (i) adding said reporter kinase to an assay mixture wherein said reporter kinase is contacted with bioluminescent reagent no more than minutes after being contacted with ADP, and wherein, prior to contacting the reporter kinase with ADP,... Agent: Health Protection Agency
20110318728 - Systems, devices, methods and kits for fluid handling: Fluid handling devices, systems, methods and kits are disclosed. Fluid handling devices according to the disclosure comprise: an inlet for receiving a sample; a reagent layer comprising, a substrate having a first surface and an opposing second surface, at least one reagent storage compartment configured to hold a reagent, and... Agent:
20110318730 - Micropatterned co-culture systems as infectious disease analysis platforms: Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite and include a reporter of virus or parasite infection. Methods of making and using the cell cultures are also provided.... Agent: Mass Institute Of Technology
20110318731 - Quantitative helicase assay: Disclosed herein are methods and kits relating to detection and quantitation of helicase activity.... Agent:
20110318736 - Allele amplification bias: Methods are provided for nucleic acid analysis. In an illustrative method, allele amplification bias is used to amplify preferentially a target nucleic acid that is present in a low allele fraction.... Agent:
20110318741 - Biomarkers for the treatment of psoriasis: Provided herein are the biomarkers for predicting or monitoring the efficacy of a treatment for psoriasis. The use of certain cell markers and mRNA levels as biomarkers to predict whether a psoriasis treatment is likely to be successful is also provided. Further, the expression of these genes or cell markers... Agent:
20110318745 - Compositions and methods for performing hybridizations with separate denaturation of the sample and probe: The invention provides methods and compositions for separately denaturing a probe and target in hybridization applications. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one polar aprotic... Agent:
20110318739 - Determination of the degree of dna methylation: The present invention provides oligonucleotides and processes for determining the normalized methylation level of DNA, and for determining the relative methylation level of DNA between at least two samples. The invention makes use of the random distribution of transposons in the genome. The disclosed oligonucleotides and processes are of importance,... Agent: Heinrich-heine-universitÄ T DÜ Sseldorf
20110318734 - Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing: Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome... Agent: The Chinese University Of Hong Kong
20110318738 - Identification and regulation of a novel dna demethylase system: Disclosed herein are methods and systems directed at detecting, evaluating, ameliorating, preventing and treating an oncogenic event. The disclosed methods and systems can comprise one or more Demethylase System Components or other compositions that can be used alone or in combination to detect, evaluate, treat, ameliorate, or prevent an oncogenic... Agent: University Of Utah Research Foundation
20110318743 - Methods, workflows, kits, apparatuses, and computer program media for nucleic acid sample preparation for nucleic acid sequencing: A method for preparing a nucleic acid sample for nucleic acid sequencing includes amplifying a nucleic acid target sequence using a primer bound to a first capture substrate; capturing an amplified nucleic acid product by the first capture substrate; generating at least one sequencing ladder from the amplified nucleic acid... Agent: Life Technologies Corporation
20110318742 - Micro rna markers for colorectal cancer: There are disclosed methods for diagnosing or providing a prognosis for colorectal cancer cells in a biological sample, the method comprising the steps of detecting the presence in the biological sample of an RNA sequence at least about 98% similar over the full sequence length to a sequence selected from... Agent: The Chinese University Of Hong Kong
20110318747 - Nonseparation assay methods: Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support as is a member of a specific binding pair for capturing an analyte from a sample. An activator compound that activates the chemiluminescent... Agent: Beckman Coulter, Inc.
20110318732 - Prediction of chemotherapeutic response via single-cell profiling of transcription site activation: The present invention generally relates to methods for determining tumor resistance or sensitivity to chemotherapeutic agents and the likelihood of tumor reoccurrence based on the expression levels of genes known to correlate to the chemotherapeutic agent. In particular, the expression levels of TYMS, MRGX, ATP7B and/or BAK in tumor cells,... Agent:
20110318746 - Rapid oligo probes: Disclosed are methods, rapid probes, and kits for general purpose nucleic acid detection.... Agent:
20110318737 - Real-time polymerase chain reaction detection of legionella pneumophila and differentiation from other legionella species: Materials and processes are provided for the detection of Legionella species in a sample. The inventive process includes exposing a sample to a forward primer and a reverse primer to yield an amplicon. The amplicon is detectable by at least one probe. The inventive process detects multiple species of Legionella... Agent: The Government Of The US As Represented By The Secretary Of The Dept.of Health And Human Services
20110318740 - Reduced interference from single strand binding proteins: Disclosed, for example, are methods for detecting at least one target polynucleotide comprising cleaving a flap from a polynucleotide probe that is hybridized to a complementary target polynucleotide, and hybridizing the cleaved flap to a complementary capture probe immobilized on a surface, wherein said cleaving and/or hybridizing occurs in the... Agent: Life Technologies Corporation
20110318735 - Regulation of the serotonin reuptake transporter and disease: Described herein is a CpG island in the 5′ region of the 5HTT gene that contains an alternative exon 1 and promoter for 5HTT. Methylation at this CpG island is associated with decreased levels of 5HTT mRNA, and this effect is evident when 5HTTLPR genotype is taken into account. Thus,... Agent: University Of Iowa Research Foundation
20110318733 - Test system and method for the detection of analytes: The invention relates to analytical test systems and analytical methods, in which molecular switches are used for the qualitative and quantitative determination of analytes in a sample, which have a broad application by means of a selection of the molecular switch suitable for the analyte. The molecular switch comprises a... Agent: Dade Behring Marburg Gmbh
20110318749 - Method for identifying regulatory t cells: The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer, cancer treatment and/or organ transplantation based on regulatory T cell quantity, to methods and kits... Agent: Centenary Institute Of Cancer Medicine And Cell Biology
20110318752 - Method for improving the yeild of a polypeptide: The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host.... Agent: DsmIPAssets B.v.
20110318750 - Methods for detecting and quantifying viable bacterial endo-spores: Methods and systems for detecting viable bacterial endospores in a sample and related methods to quantify viable bacterial endospores in a sample.... Agent:
20110318748 - Modified proteins and methods of making and using same: Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for... Agent: Life Technologies Corporation
20110318751 - Puma, a pro-apoptotic gene, as a novel molecular biomarker for tnfalpha-induced human islet damage: p53-upregulated modulator of apoptosis (PUMA) is a biomarker associated with islet cell health. If PUMA is low, islet cells are typically healthy. If PUMA is high, islet cells are typically unhealthy or dying. PUMA may be measured by either measuring its nucleic or amino acid. PUMA mRNA may be induced... Agent:
20110318753 - New compound, phosphorylation inhibitor, insulin resistance improving agent, preventive or therapeutic agent for diabetes, and screening method: A new compound inhibiting phosphorylation of Ser727 of STAT3, a phosphorylation inhibitor containing the new compound, an insulin resistance improving agent and a preventive or therapeutic agent for diabetes; and a screening method for at least one of the insulin resistance improving agent and the preventive or therapeutic agent for... Agent: Fujitsu Limited
20110318756 - Small specimen staining and diagnosing of cells: An immunohistochemical staining of small specimen comprises using a plurality of antibodies and/or antigens to mark certain cells with particular colors of stains in order to distinguish target cells, such as carcinoma cells, in a stained small specimen. For example, antibodies CD44, cytokeratin 20 and p53 may be used for... Agent: C.v. Diagnostics LLC
20110318757 - Recombinant anti-muc1 antibodies: Antibodies having a high specificity and high affinity towards the human gene product MUC1, which in specific variants is associated with neoplastic cells, i.e. tumor tissue, to the use of the antibodies for medical purposes, i.e. for tumor treatment, and for analytical purposes, e.g. for tumor diagnosis. Compositions comprising the... Agent:
20110318754 - Reduction in false results in assay measurements: Methods and reagents are disclosed for detecting a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises measuring assay signal resulting from background only and measuring assay signal resulting from the presence of analyte in... Agent: Siemens Healthcare Diagnostics Inc.
20110318755 - Universal testing platform for medical diagnostics: The invention relates to analysis of samples (for example, blood, urine, saliva, or swab). Some embodiments include a diagnostic testing platform. The platform may permit the analysis of a plurality of different samples with no or only minor modifications made to the platform. This platform may also reduce the number... Agent:
20110318763 - Detection of cancer by elevated levels of bcl-2: The present invention relates to a method for the diagnosis, prognosis, and monitoring of cancer, such as early or late stage ovarian cancer, in a subject by detecting Bcl-2 in a biological sample from the subject, preferably a urine or blood sample. Bcl-2 may be measured using an agent that... Agent: University Of South Florida
20110318762 - Graft-versus-host disease predicting marker and use thereof: A test method that provides data useful in predicting the probability of onset of acute graft-versus-host disease (GVHD) is described along with a kit for performing the method, and a pharmaceutical preparation and a molecular targeted therapy for treating or preventing GVHD. The test method includes measuring the blood DNAM-1... Agent: University Of Tsukuba
20110318758 - Human monoclonal antibodies and methods for producing the same: The present invention provides for methods of producing human monoclonal antibodies against a wide variety of antigens including bacterial and viral antigens, as well as tumor antigens, and various autoantigens. Also provided are the antibodies themselves, nucleic acids encoding such antibodies, cells producing such antibodies, and methods of using such... Agent: Musc Foundation For Research Development
20110318759 - Method for assaying keratan sulfate, assay kit therefor and method for detecting joint disease by using the same: The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50KS-I/KS-II of 0.4 to 5,... Agent: Seikagaku Corporation
20110318764 - Method for detecting muscle degenerative diseases, and method for determining therapeutic efficacy on the diseases: Muscle degenerative diseases can be detected in the early stage and the therapeutic efficacy of a therapeutic agent and/or a therapy method for the diseases can be determined by measuring 11,15-dioxo-9α-hydroxy-2,3,4,5-tetranorprostan-1,20-dioic acid (referred to as “Tetranor-PGDM”, hereinbelow) in a sample isolated from a subject.... Agent: National Center Of Neurology And Psychiatry
20110318760 - Method for the in vitro diagnosis of an autoimmune response associated with the existence of an antineutrophil cytoplasmic antibodies-associated vasculitis by detection of antibodies directed against the pentraxin 3 antigen: A method for the in vitro diagnosis of an autoimmune immune response in an individual by detection, in a biological fluid from said individual, of antibodies directed against the pentraxin 3 (PTX3) antigen, characterized in that the presence of antibodies directed against the PTX3 antigen (anti-PTX3 antibodies) are determined in... Agent: Universite D'angers
20110318761 - Methods and kits for predicting a response to an erythropoietic agent: Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the... Agent: University Of Louisville Research Foundation, Inc.
20110318765 - Method for pre-treating sample containing glycated hemoglobin: t
20110318766 - Arginine vasopressin pro-hormone as predictive biomarker for diabetes: Subject of the present invention are assays and in vitro methods for the prediction of the risk of a subject for contracting metabolic syndrome and/or diabetes mellitus and for diagnosing metabolic syndrome, comprising determining the level of arginine vasopressin pro-hormone or fragments thereof in a sample of a subject.... Agent: B.r.a.h.m.s. Gmbh
20110318767 - Method for measuring plasma glucose: A measurement of plasma glucose is carried out through the following steps, a sample preparation step (S101, S102) of preparing a measurement sample by hemolyzing hemocytes in blood, a step of measuring whole blood glucose (S103 to S105) of measuring a glucose concentration in whole blood with the measurement sample,... Agent: Arkray, Inc.
20110318769 - Method and composition for targeting vicious cycles of stresses and inflammatory responses: The present invention provides methods and compositions for targeting the pathologically relevant bipolar actions of these master integrators without affecting the basal physiologically relevant functions. NFA can be used as marker of vicious cycles. Partial inhibition of NFA will be less toxic (in most cases) and more efficient for simultaneous... Agent: National Tsing Hua University
20110318768 - Method for determining sensitivity of tumor cells to tyrosine kinase inhibitor and computer program product: The present invention provides a method for determining sensitivity of the tumor cells to an EGFR and/or HER2 inhibitor by evaluating inhibitory capacity of an Src inhibitor in a sample for measuring tyrosine kinase activity which is prepared from a biological sample containing tumor cells, a computer program and a... Agent: Sysmex Corporation
20110318770 - Compositions, kits and methods for determining plasmin activity: Compositions, kits, and methods for determining plasmin activity using a fluorogenic peptide substrate are provided.... Agent: Talecris Biotherapeutics, Inc.
20110318771 - Deuterium isobaric tag reagents for quantitative analysis: Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more 2H in each reagent. Generally, the reagents are described by the formula: reporter group—balancer group—reactive group, wherein the reporter group and the balancer group are linked by an... Agent: University Of Maryland, College Park
20110318774 - Dual sample cartridge and method for characterizing particles in liquid: The present invention relates to an apparatus for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. Furthermore, the present invention relates to a method for characterizing particles in liquid and a device... Agent: Chempaq A/s
20110318773 - Method to use ektacytometry to improve stored red blood cell or whole blood product utilization: A method for assessing the quality degradation of an RBC or whole blood unit, the method comprising: 1) using an ektacytometer to generate erythrocyte deformability data for the RBC or whole blood unit; 2) analyzing the erythrocyte deformability data to assess the quality degradation of the RBC or whole blood... Agent:
20110318772 - Reactive coumarin derivatives and their use in cellular analyses: Chemically reactive 7-hydroxycoumarin derivatives and their application for analyzing cell function, for example in combination with additional fluorescent labels. The coumarin derivatives exhibit a strong absorption at 405 nm and high fluorescence quantum yields.... Agent: Aat Bioquest, Inc.
20110318775 - Method, system and composition for optically inducing cardiomyocyte contraction: The present invention provides a method, system and composition for screening drug candidates for cardiotoxicity and for novel drugs that effect cardiomyocyte contractility and function. The invention provides an efficient and reliable screening assay to detect the effect of new and potential drug candidates on cardiomyocyte calcium flux, membrane depolarization,... Agent: Sanford-burnham Medical Research Institute
20110318776 - Method for identifying germs in a liquid medium: This invention relates to a method for identifying germs in a liquid medium, comprising adding a membrane detergent to the liquid medium containing components of a host infected with germs, i.e. cellular components and proteins from the extracellular environment, so as to release the germs from these components without degrading... Agent:
20110318777 - Device for metering cells, method for metering cells and also use of the device: The invention relates to a device for metering cells and also to a method for metering cells. Furthermore, the invention relates to the use of the device for metering cells.... Agent: Kist-europe Forschungsgesellschaft Mbh
20110318778 - Organic substrate treatment system: The present invention is directed to an organic substrate treatment system that converts organic substrate and other organic materials to nutrient rich effluent and biogas. Using sequential degradation of the organic materials, biogas and effluent is efficiently produced with relatively short digestion times. Additives are added to the organic materials... Agent:
20110318781 - Cyclodipeptide synthetase and its use for synthesis of cyclo(tyr-xaa) cyclodipeptides: Isolated, natural or synthetic polynucleotide and polypeptide encoded by said polynucleotide, that is involved in the synthesis of cyclodipeptides, recombinant vector comprising said polynucleotide or any substantially homologous polynucleotide, host cell modified with said polynucleotide or said recombinant vector and also methods for in vitro and in vivo synthesizing cyclodipeptides,... Agent: Kyowa Hakko Bio Co., Ltd
20110318780 - Enzymatic modification of glycopeptides: The present invention provides glycoconjugates that are formed through the enzymatically-mediated coupling of a glycosyl moiety, e.g., on a peptide or lipid, and a modifying group that includes an acyl group. The conjugates include the modifying group tethered to the glycosyl moiety through a linking moiety that includes an acyl... Agent: Biogenerix Ag
20110318779 - Process for producing recombinant protein using novel fusion partner: The present invention provides a method of producing polypeptide utilizing a fusion protein of A-B type in the following formula (I), by culturing transformed microorganism comprising DNA sequence encoding the desirable polypeptide; A-B (I). In the above formula (I), A is a fusion partner of 25 or more amino acid... Agent: Nutrex Technology Co., Ltd.
20110318782 - Microbial expression of tobacco osmotin for biocidal and medical applications: Disclosed herein are recombinant tobacco osmotin polypeptides and methods for expressing tobacco osmotin polypeptides in microbial host cells. The recombinant tobacco osmotin polypeptides produced by the methods disclosed herein may be utilized as biocides or as therapeutic agents in medicaments.... Agent: Auburn University
20110318783 - Microorganism producing inosine and method of producing inosine using the same: The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating... Agent: Cj Cheiljedang Corporation
20110318785 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecular Systems, Inc.
20110318786 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecular Systems, Inc.
20110318784 - Preparation and amplification of nucleic acids by means of magnetic particles: The invention relates to the preparation of a biological sample for performing verifications and examinations, wherein the aim of the invention is the creation of a method for preparing a biological sample having an improved PCR sensitivity compared to the reference standard having standard PCR without having to raise the... Agent: Qiagen Gmbh
20110318787 - Means and methods for modulating notch3 protein expression and/or the coding region of notch3; compositions and use thereof in the treatment of cadasil: The invention among other provides means and methods for modulating NOTCH3 expression and/or protein coding domain. In one aspect the invention provides a method for at least reducing an elevated level of NOTCH3 protein in a NOTCH3 expressing cell or the immediate vicinity thereof said method comprising providing said cell... Agent: Academisch Ziekenhuis Leiden H.o.d.n. Lumc
20110318788 - Multisignal labeling reagents and processes and uses therefor: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first... Agent: Enzo Life Sciences, Inc., C/o Enzo Biochem, Inc.
20110318789 - Prokaryotic dna repair ligases: The present invention relates to the cloning and characterisation of a prokaryotic DNA repair ligase, which is shown to possess a range of activities that allow the ligation and repair of non-compatible DNA ends and double strand breaks (DSBs). The enzyme has a range of applications in the manipulation and... Agent: Cambridge Enterprise Limited
20110318790 - Xylose isomerase genes and their use in fermentation of pentose sugars: The present invention relates to eukaryotic cells which have the ability to isomerise xylose directly into xylulose. The cells have acquired this ability by transformation with nucleotide sequences coding for a xylose isomerase that has one or more specific sequence elements typical for isomerases having the ability of functional expression... Agent:
20110318791 - Mutant of the prob gene from coryneform bacteria: The invention relates to processes for fermentative production of L-proline using bacteria which contain mutated variants of the proB gene.... Agent: Degussa Gmbh
20110318792 - Novel method for utilization of microbial mutant: e
20110318793 - Method of producing a low molecular weight organic compound in a cell: A method of producing a low molecular weight organic compound (e.g. a plant or bacteria secondary metabolite) in increased yields involving use of a microorganism cell, which comprises a gene involved in the biosynthesis pathway leading to a low molecular weight organic aglycon compound and a glycosyltransferase gene capable of... Agent: Evolva Sa
20110318794 - Method for producing d-lactic acid, and method for increasing optical purity of d-lactic acid or yield of d-lactic acid relative to sugar in lactic acid: Disclosed is a method for producing D-lactic acid by allowing a microorganism to utilize a purified treacle and culturing the microorganism. Also disclosed is a method for increasing the optical purity of D-lactic acid in lactic acid. Specifically disclosed is a method for producing D-lactic acid by allowing a microorganism... Agent: Agribioindustry Inc.
20110318795 - Dicarboxylic acid production in a filamentous fungus: The present invention relates to a recombinant fungus comprising an enzyme which catalyses the conversion of malic acid to fumaric acid in the cytosol. The invention further relates to a process for the production of a dicarboxylic acid such as fumaric acid and succinic acid, wherein the recombinant fungus is... Agent:
20110318796 - Method for extracting soluble sugar molecules from biomass material: Methods are provided for preparing a hydrolysate containing soluble sugar molecules from biomass that contains cellulose and hemicellulose. Hemicellulose sugars are extracted in the process, and the resulting hydrolysate may be used to support microbial fermentation to produce products of interest.... Agent: Cobalt Technologies, Inc., A Delaware Corporation
20110318797 - Cytochrome p450s and uses thereof: The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic... Agent:
20110318798 - Removal of inhibitors of microbial fermentation from inhibitor-containing compositions: Methods are provided for conditioning an inhibitor-containing composition, such as a cellulosic biomass hydrolysate, to remove inhibitors of microbial growth and/or product production. The methods include precipitation of inhibitors by formation of complexes with metal salts, such as aluminum sulfate and ferric chloride.... Agent: Cobalt Technologies, Inc.
20110318799 - Yeast organism producing isobutanol at a high yield: There is disclosed a method of producing isobutanol. In an embodiment, the method includes providing a microorganism transformed with an isobutanol producing pathway containing at least one exogenous gene. The microorganism is selected to produce isobutanol from a carbon source at a yield of at least 10 percent theoretical. The... Agent: Gevo, Inc.
20110318800 - Integrated mechanical vapor recompression (mvr) and membrane vapor permeation process for ethanol recovery (ethanol dehydration) from fermentation broth: An apparatus and process is taught for the formation of ethanol from a fermentation medium in the absence of an ethanol concentration distillation step.... Agent: Chevron U.s.a. Inc.
20110318802 - Thermophilic micro-organisms for ethanol production: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.... Agent:
20110318801 - Xylose utilization in recombinant zymomonas: Zymomonas expressing xylose isomerase from A. missouriensis was found to have improved xylose utilization, growth, and ethanol production when grown in media containing xylose. Xylose isomerases related to that of A. missouriensis were identified structurally through molecular phylogenetic and Profile Hidden Markov Model analyses, providing xylose isomerases that may be... Agent: E. I. Du Pont De Nemours And Company
20110318803 - Process for simultaneous saccharification and fermentation for production of ethanol: Methods are disclosed for the production of high concentrations of ethanol from biomass using Zymomonas as the ethanologen. Zymomonas is grown under conditions of low impeller agitation with high concentration of insoluble solids in a saccharification-fermentation mixture during a simultaneous saccharification and fermentation reaction for the production of high concentrations... Agent: E. I. Du Pont De Nemours And Company
20110318804 - Photobioreactor: A bioreactor for cultivating phototrophic microorganism, includes a transparent upper plate and a lower plate, the upper plate being disposed above and spaced apart from the lower plate and defining therebetween a continuous cultivation volume having an inlet port and an outlet port, each of the plates including a plurality... Agent: Karlsruher Institut Fuer Technologie
20110318805 - Microbial biotransformation of spent vanilla beans: A process for producing flavor constituents from spent vanilla materials, comprising treating the materials with microorganisms such as bacteria, fungi and yeast, that produce enzymes having the ability to degrade the plant cells systems of the materials, and recovering the flavor constituents so produced.... Agent:
20110318806 - Site specific incorporation of keto amino acids into proteins: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids... Agent: The Scripps Research Institute
20110318807 - Small molecule inhibitors of ghrelin o-acyltransferase: Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition.... Agent: University Of Texas, Board Of Regents
20110318808 - Engineered plant cysteine proteases and their uses: The present invention relates to potato virus NIa protease variants or fragments thereof, polynucleotides encoding them, and methods of making and using the foregoing.... Agent:
20110318809 - Method of screening placental proteins responsible for pathophysiology of preeclampsia, and marker for early diagnosis and prediction of preeclampsia: The present invention relates to a method of screening placental proteins responsible for pathophysiology of preeclampsia, and a marker for early diagnosis and prediction of preeclampsia. In accordance with one aspect of the present invention, there is provided a method of screening placental proteins responsible for pathophysiology of preeclampsia by... Agent:
20110318810 - Flavin-binding glucose dehydrogenases: A flavin-binding glucose dehydrogenase with a high substrate specificity for D-glucose. The flavin-binding glucose dehydrogenase which is derived from a microorganism belonging to the genus Mucor. The flavin-binding glucose dehydrogenase has a low reactivity for maltose, D-galactose and D-xylose compared to its reactivity for D-glucose, and therefore is relatively unaffected... Agent: Kikkoman Corporation
20110318811 - Compositions and methods of using a synthetic dnase i: Compositions and method for making and using a synthetic bovine DNase I are disclosed. More particularly, the sbDNase I of the present invention is a versatile enzyme that cleaves DNA nonspecifically to release 5′-phosphorylated nucleotides. The sbDNase I molecules of the present invention find particular use in a wide range... Agent: Applied Biosystems, LLC
20110318812 - Recombinantly modified plasmin: Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.... Agent:
20110318813 - Chimeric pestivirus with insertion in 3' nontranslated region (3' ntr) with stable replication and rnase resistance: The construction of a chimeric Pestivirus by the identification of selected regions in the 3′NTR of the viral RNA genome is described where additional RNA sequences can be stably inserted. These sequence insertions in the viral RNA genome were stable in replication and capable of forming infectious, RNase resistant virus... Agent: Life Technologies Corporation
20110318814 - Methods, kits and systems for processing samples: A method for isolating microorganisms from a sample, the sample including sample matrix and microorganisms, the method including the steps of providing a receptacle, the receptacle configured to allow filtering of the sample and to reversibly contain the sample and a concentration agent; adding the sample to the receptacle, wherein... Agent:
20110318815 - Method and system for growing microalgae in an expanding plug flow reactor: A method and system are provided for supporting the growth of algae cells. In the method, an inoculum of algae cells are grown in a closed bioreactor. Thereafter, the inoculum of algae cells is passed into an open system. Specifically, the inoculum is passed into an expanding plug flow reactor... Agent:
20110318816 - System for moderating the temperature of a medium for growing microalgae: A system is provided for moderating the temperature of a medium for growing microalgae and for distilling fresh water. In the system, the medium flows through a conduit having two ends and a bottom. As the sunlight passes into the medium, the algae grows and the medium is heated. For... Agent:
20110318817 - Compact air purifier: An air purifier with a tub capable of containing a liquid. Reactor plates are in the tub wherein the reactor plates provide a curvilinear path for air flow with abrupt directional change. A pump is situated to distribute the liquid onto the reactor plates to form a moist surface. An... Agent: Sgblue, Inc.
20110318818 - Straw for the conservation of a predetermined dose of a liquid base substance, in particular a biological substance: The straw comprises a tube (41) and a plug (42) consisting of a one-piece cylinder of microporous material, permeable to gases and liquid tight. The microporous material is a sintered self-sealing microporous material with at least a solid portion (42) having a diameter matching the inner diameter of said tube... Agent: Imv Technologies
20110318819 - Device for cultivating algae and/or microorganisms for treating an effluent, and biological frontage: Device for processing effluents includes: a container for cultivating algae and/or microorganisms in an aqueous medium; supply elements for the algae and/or microorganism culture; elements for injecting an effluent into the algae and/or microorganisms, the effluent coming from a building; elements for adjusting the temperature of the algae and/or microorganism... Agent: X'tu
20110318821 - Bioagent detection methods: The present invention relates the use of broad range primer (e.g., as broad range capture olignucleotides) immobilized in a SCODA method gel to allow, for example, selective concentration of target nucleic acids. Such concentrated target nucleic acids may, for example, be: i) eluted from the gel and analyzed (e.g., by... Agent: Ibis Biosciences Inc.
20110318820 - Immobilized buffer particles and uses thereof: The disclosure relates to novel particle compositions and methods of making said compositions having applications in nucleic acid analysis, as well as apparatuses and systems for the same.... Agent: Life Technologies Corporation
20110318822 - Analytical strip: This invention discloses an analytical strip comprising a substrate. The substrate has a channel provided concavely on the upper surface thereof. The channel comprises a first area for receiving a fluid sample, a second area for delivering the fluid sample, and a third area where the fluid sample reacts. These... Agent:
20110318823 - Fermentation apparatus: An apparatus for the fermentation of a vegetable product in the form of crushed material, includes a first tank for containing the crushed material and a second collection tank for the gaseous products generated from the crushed material's fermentation, a first piping system adapted to let communicate a part of... Agent:
20110318824 - Cartridge system for chemical processing: An end portion of a head has a recess having an inner shape corresponding to a dome shape of a well when the well is in an expanded state. The radius of curvature of the recess is larger than the radius of curvature of the dome shape of the well.... Agent: Yokogawa Electric Corporation
20110318825 - In situ heat induced antigen recovery and staining apparatus and method: An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do... Agent:
20110318827 - Cysteine-free efficient technetium (tc) or rhenium (re) chelating peptide tags and their use: The present invention relates to a peptide tag which can be used to bind a Technetium (Tc) or Rhenium (Re) radionuclide to a protein of interest which comprises the peptide tag and allows the imaging of such a tagged protein. In particular the present invention relates to a peptide tag... Agent:
20110318826 - Inotropic antibodies and therapeutic uses thereof: Antibodies binding to sites on the alpha-subunit of the (Na++K+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In particular, antibodies binding to the RSATEEEPPNDD (SEQ ID NO: 1) or DVEDSYGQQWTYEQR (SEQ ID NO: 2) peptides (or isoforms/derivatives thereof) of the alpha-subunit of the (Na++K+)-ATPase, have been found... Agent:
20110318829 - Cell culture container and cell culture method: To provide a cell culture chamber and a cell culture method that are capable of effectively constructing an intercellular network in a culture space. A cell culture chamber (10) according to the present invention is a cell culture chamber (10) including a plurality of microchambers (11) formed on a surface... Agent: Kuraray Co., Ltd.
20110318828 - Kit for preparation of antigen-specific cytotoxic lymphocytes: The invention is intended to further improve the operability, economic efficiency and safety in the preparation of antigen-specific CTLs. The invention provides a preparation kit used for a method for preparing antigen-specific cytotoxic T lymphocytes, the method comprising: a first step for inducing antigen-specific cytotoxic T lymphocytes, wherein the components... Agent:
20110318830 - Compositions and methods for re-programming and re-differentiating cells: The invention provides compositions and in vitro and ex vivo methods for de-differentiating or re-programming mammalian cells. In alternative embodiments, the invention provides compositions comprising mixtures of Designed Regulatory Proteins (DRPs) or Reprogramming DRP protein (ReD) for de-differentiating or re-programming mammalian cells. The invention also provides compositions and methods for... Agent: The Regents Of The University Of California
20110318831 - Chinese hamster apoptosis-related genes: Provided is an isolated polypeptide comprising a Cricetulus griseus sequence capable of mediating apoptosis of a cell, the sequence being selected from a FAIM sequence shown as SEQ ID NO: 1; a FADD sequence shown as SEQ ID NO: 2; a PDCD6 sequence shown as SEQ ID NO: 3; and... Agent: Agency For Science, Technology And Research
20110318833 - Adipose-derived stem cells and laticces: The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues... Agent:
20110318832 - Human telomerase catalytic subunit: The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and... Agent: Geron Corporation
20110318838 - Cell-type specific aptamer-sirna delivery system for hiv-1 therapy: The present invention relates to compositions and methods for delivery of siRNA to specific cells or tissue. More particularly, the present invention relates to compositions and methods for cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer.... Agent: City Of Hope
20110318835 - Implant surface treatment method having tissues integrated: The present disclosure uses different kinds of surface treatment processes on titanium-made dental implants. The growth and attachment conditions of bone cells (MC3T3-E), fibroblasts(NIH 3T3) and epidermal cells (XB-2) on the metal surface of titanium slices with different surface treatments are observed. Tetra-calcium phosphate is used to perform secondary sand-blasting... Agent: Kaohsiung Medical University
20110318839 - Method for enhancing a function of a t cell: Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method.... Agent:
20110318836 - Method of enriching spermatozoa of mammals bearing x-chromosome or y-chromosome: The present invention relates to an immunological method that selects spermatozoa having X-chromosome or Y-chromosome. The method of the invention is based on the use of monoclonal antibodies directed against the genus-specific proteins located in the cytoplasm membrane of spermatozoa associated to the action of the classical complement pathway to... Agent: Hy Biotecnologica Ltda.
20110318837 - Methods and compositions for inducing apoptosis by stimulating er stress: The present invention provides a method for inducing apoptosis in selected cells by aggravating ER-stress. The aggravation of ER-stress is achieved in a specific manner by inhibiting SERCA (sarcoplasmic/endoplasmic reticulum calcium ATPase), leading to elevated level of cytoplasmic calcium concentration, yet without inhibiting the activity of COX-2 (cyclooxygenase-2) or triggering... Agent: University Of Southern California
20110318834 - Multiple-tumor aberrant growth genes: The invention relates to the multi-tumor aberrant growth gene having the nucleotide sequence of any one of the strands of any one of the members of the High Mobility Group protein genes or LIM protein genes, including modified versions and derivatives thereof. The gene and its derivatives may be used... Agent: Vlaams Interuniversitair Instituut Voor12/22/2011 > 137 patent applications in 72 patent subcategories.
20110311959 - Solution for preserving liver: The present invention provides a liver preservation solution containing trehalose and dibutyryl-cAMP. The content of nitroglycerin in the preservation solution is preferably lower than 0.44 mM. In the liver preservation solution of the present invention, since the toxicity due to nitroglycerin, which is observed during liver preservation, has been improved,... Agent:
20110311960 - Method and device for identification of nucleated red blood cells from a maternal blood sample: A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal... Agent:
20110311961 - Detection of nucleic acids from multiple types of human papillomaviruses: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products... Agent: Gen-probe Incorporated
20110311962 - Method for high-resolution detection of nanoparticles on two-dimensional detector surfaces: The invention relates to a surface plasmon resonance spectrometer comprising a radiation source that emits substantially monochromatic radiation, a sensor surface, an optical arrangement for lighting the sensor surface by the radiation emitted from the radiation source such that surface plasmons can be created in the sensor surface, a detector... Agent:
20110311966 - Detection conjugate and method for analysis: The invention provides a combination of reagents as a test kit containing a detection conjugate having a binding portion and a reagent for deactivating of the fluorochrome portion by interaction with the linker. The binding portion especially is an antibody portion. The detection conjugate has a fluorochrome portion connected to... Agent: Medizinische Hochschule Hannover
20110311964 - Labeled reactants and their uses: Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated.... Agent: Pacific Biosciences Of California, Inc.
20110311963 - Method and apparatus for addressable flow cells in single molecule sequencing: A method of sequencing a plurality of template nucleotide sequences includes immobilizing the plurality of template nucleotide sequences on a substrate. A first subset of the plurality of template nucleotide sequences is immobilized in a first field of view and a second subset of the plurality of template nucleotide sequences... Agent: Life Technologies Corporation
20110311965 - Methods of enhancing translocation of charged analytes through transmembrane protein pores: The invention relates to enhancing translocation of a charged analyte through a transmembrane protein pore. Translocation is enhanced by increasing the net opposing charge of the barrel or channel and/or entrance of the pore. The invention also relates to pores enhanced in accordance with the invention.... Agent: Isis Innovation Limited
20110311968 - Allele-specific amplification of nucleic acids: The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, having an internally-placed selective nucleotide complementary to only one variant of the target sequence wherein the allele-specific oligonucleotide is extended by a nucleic acid... Agent: Roche Molecular Systems, Inc.
20110311970 - Compositions and methods for intracellular analyte analysis: Compositions and methods for multiplex immunodetection of analytes in single cells or cell populations are described. The invention utilizes analytical nanotags (ANTs) each specific for a different target analyte (TA) species. Analytical nanotags typically comprise biocompatible composite organic-inorganic nanoparticles (bCOINs) that include probe molecules specific for a particular TA species.... Agent:
20110311974 - Compositions and methods for performing a stringent wash step in hybridization applications: The invention provides methods and compositions for performing a stringent wash step in a hybridization assay between at least one molecule and a target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in the stringent wash step. Compositions for use in the invention... Agent:
20110311973 - Compositions for detecting human interferon-alpha subtypes and methods of use: The invention provides highly sensitive, specific and efficient quantitative real-time PCR compositions, methods and assay kits to detect at least one IFN subtype and/or IFN subtype allotypic variants. Primer/probe sets complementary to the coding sequence of an IFN subtype of interest avoid spurious detection of degraded mRNA and enhances the... Agent: Usa, As Represented By The Secretary, Department Of Health & Human Services (the Government)
20110311969 - Diagnostic kit for aspergillus fumigatus species: The use of the Ayg1 gene or an RNA transcript of the Ayg1 gene or fragments thereof as target regions in a diagnostic assay for the eukaryotic organism Aspergillus fumigatus species is described. The unique sequence of the Ayg1 gene in Aspergillus fumigatus provides the basis of nucleic acid diagnostic... Agent: National University Of Ireland, Galway
20110311972 - Dpyd gene variants and use thereof: Variants in DPYD gene are disclosed which can result in abnormal synthesis of DPD proteins and alteration of DPD activities. The invention provides methods for detecting the newly discovered genetic variants. The DPD genetic variants of the invention can be used as biomarkers in predicting toxicity to 5-FU and other... Agent: Myriad Genetics, Incorporated
20110311975 - Genomic selection and sequencing using encoded microcarriers: The present invention relates to a method for determining the sequence of a nucleic molecule. Herein a capture oligonucleotide probe is attached to an encoded microcarrier, wherein the code of said microcarrier identifies the sequence of said oligonucleotide probe. The capture oligonucleotide probe is hybridized with a sample comprising nucleic... Agent: Koninklijke Philips Electronics N.v.
20110311967 - Novel single nucleotide polymorphisms and combinations of novel and known polymorphisms for determining the allele-specific expression of the igf2 gene: Single nucleotide polymorphisms and uses for determining the imprinting status of the Insulin Growth Factor-2 gene in a clinical specimen are described.... Agent: Orion Genomics LLC
20110311971 - Rt-late-pcr: An assay comprising more than one primer pair and more than one detection probe, a low copy number synthetic amplicon corresponding to each of the primer pairs. The assay can detect and distinguish between various sub-types and strains of an influenza virus using any suitable nucleic acid amplification technique. Related... Agent: Brandeis University
20110311983 - Fuidi herd management schema: The invention is a herd management schema based upon the inventor's analysis of the natural history of bovine infection due to Mycobacterium avium subspecies paratuberculosis (Map) and related genomic variants and upon the ability of two distinct Map ELISA tests to sequentially or in parallel determine prior and current Map... Agent:
20110311977 - In vitro generation of hepatocytes from human embryonic stem cells: Differentiation of human pluripotent stem cells, such as human embryonic stem cells (hESC), into hepatocytes by in vitro methods is disclosed. The pluripotent stem cells are cultured in conditioned medium from the hepatocarcinoma cell line, HepG2. Specific growth factors and defined media may also be added to the medium for... Agent:
20110311979 - Method for detecting the presence of a single target nucleic acid in a sample: A miniaturized assembly is provided whereby a fluid sample can be divided into a plurality of sample portions in retaining wells and the sample fluid can be displaced from open ends of the wells while simultaneously being sealed in the wells. A method of dividing a fluid sample using the... Agent: Applied Biosystems, LLC
20110311981 - Method of determining lymph node metastasis in a lung cancer, apparatus for determining lymph node metastasis in a lung cancer, and computer program product: A method of determining a lymph node metastasis in a lung cancer, comprising: acquiring mRNA expression level of stratifin contained in a measurement sample prepared by using a lymph node tissue of a lung cancer patient who may have a lymph node metastasis; and determining that the lymph node tissue... Agent: Sysmex Corporation
20110311980 - Nucleic acid amplification and sequencing on a droplet actuator: The invention provides a droplet actuator device, as well as systems, methods and devices making use of the droplet actuator device. The droplet actuator device may include a substrate having electrodes arranged for conducting one or more droplet operations. The droplet actuator device may include a substrate having a reactor... Agent: Advanced Liquid Logic, Inc.
20110311982 - Nucleic acid isolation using polidocanol and derivatives: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to... Agent: Roche Molecular Systems, Inc.
20110311976 - Primers for use in detecting beta-lactamases: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain beta-lactamases. The primers can be employed in methods to identify nucleic acid characteristic of family-specific beta-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.... Agent: Creighton University
20110311978 - System for detection of spaced droplets: System, including methods and apparatus, for detection of spaced droplets.... Agent: Quantalife, Inc.
20110311986 - Cell lines comprising sour-taste receptors: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste... Agent: Duke University
20110311984 - Composition for diagnosing parkinson's disease containing adipose tissue-derived mesenchymal stromal cell: The present invention relates to a composition for diagnosing a Parkinson's disease comprising mesenchymal stromal cells derived from adipose tissue, a method of providing information for diagnosing Parkinson's disease and/or the extent of the disease progression, a biomarker for diagnosing a Parkinson's disease, and a method of screening a drug... Agent: Snu R&db Foundation
20110311985 - Rnai based selection system: The present invention provides a novel RNAi based selection system for selecting host cells that have incorporated an expression vector.... Agent: Qiagen Gmbh
20110311987 - Oxygen detection using metalloporphyrins: An oxygen sensor includes a metalloporphyrin for detecting oxygen levels. The oxygen sensors may also include a light source and a detector. The sensors are configured to measure changes in spectra in response to the redox reaction. They can detect a variety of samples for presence and changes in oxygen... Agent: Empire Technology Developement LLC
20110311988 - Polymer end group detection: Provided herein are processes of detecting and quantifying the number of polymer end groups in a sample. In particular instances provided herein are processes of detecting.... Agent: Zacharon Pharmaceuticals, Inc.
20110311991 - Methods of identifying modulators of the bitter taste receptor tas2r44: Steviol glycosides have been discovered to bind the bitter taste receptor TAS2R44. Novel methods of identifying modulators and in particular inhibitors to the bitter taste of steviol glycosides and an inhibitor of steviol glycosides are provided.... Agent: Givaudan Sa
20110311992 - Method of prognosis and/or diagnosing an irs in a patient infected with m. tuberculosis and optionally hiv: The invention relates to a method of prognosing and/or diagnosing a M. tuberculosis-Immune restoration syndrome (TB-IRS) in an individual infected with M. tuberculosis and optionally HIV comprising comparing the percentage or concentration of γδ+ or γδ+Vδ2+T-lymphocytes which express an inhibitory KIR receptor with a predetermined value.... Agent: Institut National De La Sante Et De La Recherche Medicale (inserm)
20110311993 - Device for detection of antigens and uses thereof: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.... Agent: Invisible Sentinel
20110311989 - Antibody to n-terminal region of hemoglobin beta-chain: Provided is a general-purpose technique capable of measuring the HbA1c content, which is comparable to the IFCC reference method. An antibody which reacts with a peptide or a protein having an amino acid sequence of VHLTPE (SEQ ID NO: 1) at the N-terminus in which the N-terminal valine is not... Agent: Sekisui Medical Co., Ltd.
20110311990 - Tetranor-pgem/pgam specific immunogens, antibodies, tracers, assay kits and methods for making same: Tetranor-PGEM/tetranor-PGAM-specific antibodies, immunogens used to generate them, the processes of their manufacture, and their uses for detecting and quantifying tetranor-PGEM in biological fluids for determining biosynthesis of PGE2 in a subject or patient.... Agent: Cayman Chemical Company, Incorporated
20110311998 - A+ biomarker assays: Disclosed herein assay methods which comprise detecting the presence, absence or amount of at least one antibody which specifically binds a first biomarker or an epitope thereof and at least one second biomarker in a sample which comprises a single reaction step whereby both a first capture reagent for the... Agent:
20110311994 - Avian vaccines possessing a positive marker gene: The present invention provides a poultry vaccine containing a positive marker gene. More specifically, recombinant turkey herpesvirus modified by the presence of an extraneous antigen gene that may be used as a positive marker to identify and track vaccinated animals is provided. When inoculated into host animals, a poultry vaccine... Agent:
20110311999 - Diagnostic prediction of rheumatoid arthritis and systemic lupus erythematosus: The present invention pertains to a diagnostic assay for the diagnosis of an autoimmune disease. The present invention provides an improved diagnostic assay for the diagnosis of an autoimmune disease, particularly rheumatoid arthritis (RA) and Systemic Lupus Erythematosus (SLE). In particular the invention pertains to a method of determining in... Agent: Max-planck Gesellschaft Zur Forderung Der Wissenschaften E.v.
20110311995 - Method for the diagnosis of systemic scleroderma or of pulmonary arterial hypertension: The invention relates to an in vitro method for detecting systemic scleroderma (SSc) and/or pulmonary arterial hypertension (PAH), or a risk of developing SSc or PAH, which comprises determining the presence and/or the amount of antibodies in a biological sample originating from a patient.... Agent:
20110311997 - Methods for estimating prion concentration in fluids and tissue by quantitative pmca: The present embodiments disclose methods for estimating PrPSc concentration in fluids and tissues by quantitative PMCA.... Agent:
20110311996 - Optical particle detector and detection method: A particle detector apparatus for optically ascertaining a number of particles arranged on a surface, for example, a particle filter. The particle detector apparatus includes a light source, an optical focusing device, a spatially resolving light detector and an evaluation device. The light source emits source light onto the surface.... Agent: Eads Deutschland Gmbh
20110312000 - Monoclonal antibody and use thereof: The purpose of the invention is to provide an antibody which recognizes OPN N-half but does not recognize the full-length OPN, and its use. A monoclonal antibody which is characterized in that it recognizes a protein or polypeptide in which the C-terminal amino acid sequence is YGLR (SEQ ID NO:... Agent: Immuno-biological Laboratories Co., Ltd.
20110312001 - Compendium of ready-built stem cell models for interrogation of biological response: The invention generally features methods for providing engineered pluripotent stem cells that can be used to study biological response and pathways, including differentiation and drug effects. For example, these cells are provided comprising two or more exogenous expression cassettes including a selectable or screenable marker under the control of different... Agent:
20110312002 - Nmr detection of coagulation time: The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors.... Agent:
20110312003 - Determining performance characteristics of a fermenter batch of a biofuel production plant: A method for determining performance characteristics of a fermenter batch in a biofuel production plant based on stoichiometry of fermentation reactions, comprising determining a cell mass of a sample of the fermenter batch; a glucose equivalent total (GET) based at least on the cell mass of the sample of the... Agent: Rockwell Automation Technologies, Inc.
20110312004 - Test strip with magneto-elastic-resonance sensor: A test meter system for testing a characteristic of a fluid, the test meter system including a test meter having a housing with an opening adapted to accept a test strip, an interrogation coil within the housing, a pick-up coil within the housing, and a test strip including at least... Agent: Bayer Healthcare LLC
20110312005 - Enzymatic modification of cell-surface h antigen by glycosyltransferases: This invention relates to cells with modified blood group antigen expression. In particular, the invention relates to cells for use in haematology, immunohaemotology and immunology assays as serology controls.... Agent: Kode Biotech Limited
20110312007 - Detection of histone deacetylase inhibition: i
20110312006 - Enzymatic assay for the quantitative determination of phospholipase a1 or a2 activity in a sample: The invention relates to a new method for measuring a calcium-dependent phospholipase A1 or A2 enzymatic activity in a sample, comprising the following steps: a) contacting said sample with a solid phase coated with a fluorochrome-labelled phospholipase A1 or A2 substrate, wherein the molecular coverage is in the range 8... Agent: Aterovax
20110312008 - Enzymatic assay for the quantitative determination of phospholipase a1 or a2 activity in a sample: The invention relates to a new method for measuring phospholipase A1 or A2 activity in a sample, using a solid phase coated with a fluorochrome-labelled phospholipase A1 or A2 substrate, wherein the molecular coverage is in the range from 8 to 30 fluorochrome-labelled phospholipase A1 or A2 substrate molecules/nm2, and... Agent: Aterovax
20110312010 - Comparison of protein samples: Methods of qualitatively and/or quantitatively detecting the presence of mutations, modifications or impurities in a protein sample are provided. The methods utilize isotopically labeled variants of amino acids incorporated into proteins prior to protein digest to enable comparisons of two protein samples in bottom-up liquid chromatography.... Agent: Abbott Laboratories
20110312009 - Composition for assaying glycated proteins: Compositions for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) stabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while avoiding the effects of glycated hemoglobin, and an assay method are... Agent:
20110312011 - Diagnostic devices and methods of use: The present invention relates to methods of diagnosing samples as well as various microfluidic, microcentrifuge and microfilter devices. In one embodiment, the present invention provides a method of diagnosing neurodegenerative diseases using mitochondrial and/or platelet samples. In another embodiment, the present invention provides a microfluidic device that selectively captures and... Agent: Catholic Healthcare West
20110312018 - Blood-brain barrier model: A method of creating a multicellular blood-brain barrier model is disclosed. In one embodiment, the method comprises culturing primary brain microvascular endothelial cells or embryonic stem cell-derived endothelial cells upon a permeable support in the presence of neural progenitor cells.... Agent:
20110312017 - Diagnosis of entry of gastrointestinal contents into respiratory tract of humans and animals: A method of diagnosing respiratory fluid in a patient suffering from gastro esophageal reflux disease (GERD) is disclosed. The method comprises (1) orally administering to a subject suspected of suffering from gastro esophageal reflux disease (GERD), a formulation comprised of a plurality of particles comprised of a biocompatible polymer (e.g.... Agent: Aradigm Corporation
20110312012 - Method and kit for assessing viable cells: The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells, such as viability. The present invention relates to the use of various optionally substituted reporter compounds particularly detectable upon their reaction with thiol-containing species present in higher concentrations in intact (e.g.,... Agent: Chemometec A/s
20110312013 - Method and kit for examination of cells using n-(9-acridinyl) maleimide (nam) or using 7-diethylamino-3-((4'-iodacetyl)amino)phenyl)-4-methylkcoumarin (cpi): The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells. The present invention relates to the use of N-(9-acridinyl)maleimide (NAM) or to the use of 7-diethylamino-3-((4′-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species (e.g., sulphur-containing species) present in higher concentrations... Agent: Chemometec A/s
20110312016 - Method for evaluating immunosuppression: Provided is a method for determining immunosuppression in an individual. The method entails obtaining a sample of blood from an individual, contacting cells in the blood sample with an activating agent to obtain activated cells, measuring the amount of nuclear NFkB in the activated cells, and comparing the amount of... Agent: The Research Foundation Of State University Of New York
20110312014 - Probe for detection and quantification of nitric oxide, and method for detecting and quantifying nitric oxide using the same: Probe 1 for detection and quantification of nitric oxide, which comprises two subunits 21 and 22 of soluble guanylate cyclase 2 and cGMP-visualization probes 3 respectively connected with each subunit, wherein the cGMP-visualization probe generates signal upon recognizing guanosine 3′,5′-cyclic monophospate.... Agent:
20110312015 - Rapid thrombochek test kit based on whole blood screening test to detect platelet hyperaggregation at a temperature of 37ºc in the clinical laboratory: The new RAPID THROMBOCHEK TEST KIT is based on thrombochek screening test for measurement of hyperaggregable platelets in whole blood, which may be present either in form of circulating platelet aggregates, spontaneously aggregating platelets or reacting to weak agonist of platelet aggregation in low concentration—all together, in order to investigate... Agent:
20110312020 - Ex-vivo passive protection bacteremia assay: The present disclosure provides methods for assessing bactericidal antibodies in a biological sample by use of human fresh whole blood from a non-immune human as a reaction medium for the assay.... Agent:
20110312019 - Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics: The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of... Agent: Stemina Biomarker Discovery, Inc.
20110312021 - Method and apparatus for the non-invasive monitoring of gas exchange by biological material: The invention provides an indirect pressure sensing system for non-invasive measurement of primary pressure in a sealed container, which communicates primary pressure changes from within the container, via a flexible diaphragm, to a secondary chamber wherein there is a defined relationship between the primary and secondary pressures, which enables a... Agent: Bactest Limited
20110312022 - Method for determining percent hybridity in modified hybrid crops: Methods of introducing sentinel traits into foundation seed are described. The frequency of occurrence of the sentinel trait in the hybrid seed product relative to the frequency of the sentinel trait in a pollinator seed product are used to determine the percentage of hybridity in modified hybrid varieties.... Agent: Agrigenetics, Inc.
20110312023 - Integrated technology of algae bio-diesel and algae ferment reuse: An integrated technology of algae bio-diesel and algae ferment reuse includes providing algae, placing the algae into an optical reactor to grow the algae into rich algae, abstracting the rich algae to form abstracted algae and fat, placing the abstracted algae into a ferment tank so that the abstracted algae... Agent:
20110312024 - Method of and apparatus for fermenting biomass: The invention relates to a method of and an apparatus for fermenting organic material in an apparatus comprising a container. The method includes the steps of feeding organic material and fermenting microbes (414) to a lower portion (410) of the container, whereby material already existing in the container (419, 421)... Agent:
20110312025 - Improved production of riboflavin: The present invention provides an improved biotechnological production of riboflavin (also referred herein as vitamin B2) through modification in the operon containing the riboflavin biosynthetic genes (rib operon), in particular modifications of/in the leader sequences (rib leader) upstream of the corresponding riboflavin biosynthetic genes (rib operon). Furthermore, the present invention... Agent:
20110312026 - Process for the production of riboflavin: The invention relates to processes and means for the biotechnologically fermentative production of riboflavin (hereinafter also referred to as vitamin B2) and means for the implementation of this process, in particular a modified microbial host cell with increased riboflavin yield. The invention thus provides new processes and means for the... Agent:
20110312027 - Production of carrier-peptide conjugates using chemically reactive unnatural amino acids: Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods... Agent:
20110312030 - Consistent high expression vector containing rep e mutated gene: A vector for constitutively expressing a high level of a target protein, and more particularly a RepE mutant protein containing a deletion of 21 amino acids in the C-terminal region of a RepE protein and a vector for constitutively expressing a high level of a target protein, which comprises a... Agent:
20110312028 - Novel lipolytic enzyme elip: The present invention provides a novel nucleic acid sequence, designated ELIP, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for... Agent:
20110312029 - Novel regulatory elements: The invention concerns novel regulatory elements as well as related vectors and cells. Furthermore, it relates to methods of improving expression of polypeptides from nucleic acids such as cloned genes and to the production of various polypeptides in host cells using said novel regulatory elements. Additionally, the invention relates to... Agent: Boehringer Ingelheim Pharma Gmbh & Co, Kg
20110312031 - Trichoderma promoter: A promoter for use in producing proteins in filamentous fungal host cells is provided. In one embodiment, the promoter comprises SEQ ID NO:1, or a variant or a truncated form thereof that has promoter activity in a host cell. Also provided are recombinant nucleic acids, vectors containing the promoter and... Agent: Danisco US Inc.
20110312032 - Vectors and yeast strains for protein production: Lower eukaryote host cells in which the function of at least one endogenous gene encoding a chaperone protein, such as a Protein Disulphide Isomerase (PDI), has been reduced or eliminated and at least one mammalian homolog of the chaperone protein is expressed are described. In particular aspects, the host cells... Agent:
20110312033 - Methods of spraying saccharification enzymes and fermentation organisms onto lignocellulosic biomass for hydrolysis and fermentation processes: The present invention provides spray methods of delivering saccharification enzymes, fermentation organisms, and other hydrolysis or fermentation ingredients onto lignocellulosic biomass. The methods reduce the need for mechanical mixing when the biomass solids are undergoing enzymatic hydrolysis, and reduce dilution to allow higher product titers in the hydrolysis and/or fermentation... Agent:
20110312034 - Recombined molecules and preparation thereof: The invention relates to novel molecules and libraries thereof as well as methods for their production. Methods of producing the novel molecules include the cleaving of starting molecules into molecular subunits and the assembly of the subunits into novel recombined molecules.... Agent: Valent Technologies
20110312039 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecular Systems, Inc.
20110312037 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecular Systems, Inc.
20110312038 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecular Systems, Inc.
20110312036 - Microchip for isothermal nucleic-acid amplification reaction, method for producing the same, and isothermal nucleic-acid amplification method: A microchip for an isothermal nucleic-acid amplification reaction in which at least one of substances necessary for an isothermal amplification reaction of a nucleic acid is present in a reaction region functioning as a reaction field of the reaction, the at least one of the substances being covered with a... Agent: Sony Corporation
20110312035 - Stabilized compositions of thermostable dna polymerase and anionic or zwitterionic detergent: The present invention provides compositions, methods, and kits for protecting thermostable DNA polymerase during amplification reactions conducted at a temperature ranging from about 40° C. to greater than 100° C. The composition comprises a thermostable DNA polymerase and an anionic detergent or zwitterionic detergent.... Agent: Sigma-aldrich Co.
20110312041 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecular Systems, Inc.
20110312040 - Preferential amplification of mrna over dna using chemically modified primers: The present invention relates to a method, oligonucleotides, reaction mixtures and kits for the selective amplification of a messenger RNA target comprising an exon-exon junction, using an oligonucleotide that comprises at least one nucleotide modified at the exocyclic amino group.... Agent: Roche Molecular Systems, Inc.
20110312042 - Method for producing amino acid: According to the present invention, a process for producing an amino acid using a microorganism in which aspartate aminotransferase activity is decreased or deleted, and which has the capability of producing and accumulating the amino acid is provided.... Agent: Kyowa Hakko Bio Co., Ltd.
20110312043 - Extraction solvents derived from oil for alcohol removal in extractive fermentation: In an alcohol fermentation process, oil derived from biomass is hydrolyzed into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be catalytically (e.g., enzymatically) hydrolyzed into free fatty acids, which form a fermentation product... Agent: Butamax(tm) Advanced Biofuels LLC
20110312044 - Extraction solvents derived from oil for alcohol removal in extractive fermentation: In an alcohol fermentation process, oil derived from biomass is chemically converted into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be chemically converted into a reaction product, such as fatty acids, fatty alcohols,... Agent: Butamax(tm) Advanced Biofuels LLC
20110312045 - Fermentation processes: The present invention provides a method for the production of at least one of a fermentation product and a derivate thereof comprising the steps of: a. providing a fermentable aqueous solution comprising at least one fermentable compound and at least one impurity; b. selectively extracting the at least one impurity... Agent: Eyal Research Consultants Ltd
20110312046 - Methods for c4 dicarboxylic acid production in filamentous fungi: The present invention relates to methods of producing C4-dicarboxylic acids, such as malic acid, comprising: (a) cultivating a host cell comprising a polynucleotide encoding a C4-dicarboxylic acid transporter; and (b) recovering the C4-dicarboxylic acid. The present invention also relates to methods for increasing C4-dicarboxylic acid production, as well as host... Agent: Novozymes, Inc.
20110312047 - Polypeptides having c4 dicarboxylic acid transporter activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having C4-dicarboxylic acid transporter activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, and methods of producing C4-dicarboxylic acids, such... Agent: Novozymes, Inc.
20110312048 - Conversion method: A process is described for the preparation of water-soluble cellulose hydrolysis products The process comprises admixing cellulose with an ionic liquid capable of solvating or dissolving at least some of the cellulose, said ionic liquid being a compound comprised solely of cations and anions and which exists in a liquid... Agent: The Queen's University Of Belfast
20110312050 - Continuous catalytic generation of polyols from cellulose: A catalytic process for generating at least one polyol from a feedstock comprising cellulose is performed in a continuous manner using a catalyst comprising nickel tungsten carbide. The process involves, contacting, continuously, hydrogen, water, and a feedstock comprising cellulose, with the catalyst to generate an effluent stream comprising at least... Agent: Uop LLC
20110312049 - Microorganisms and methods for the production of ethylene glycol: The invention provides non-naturally occurring microbial organisms having an ethylene glycol pathway. The invention additionally provides methods of using such organisms to produce ethylene glycol.... Agent:
20110312051 - Process for generation of polyols from saccharide containing feedstock: A process for generating at least one polyol from a feedstock comprising saccharide is performed in a continuous or batch manner. The process involves, contacting hydrogen, water, and a feedstock comprising saccharide, with a catalyst system to generate an effluent stream comprising at least one polyol and recovering the polyol... Agent: Uop LLC
20110312052 - Process for cell-free production of chemicals: An enzymatic process is described for the production of chemicals from carbon sources. In particular, according to one aspect, a process for the production of a target organic compound from a carbon source by a cell-free enzyme system is disclosed.... Agent: Sud-chemie Ag
20110312053 - Supplementation of fatty acids for improving alcohol productivity: Fatty acids derived from biomass at a step in a fermentation process can be added to a fermentation medium comprising a recombinant microorganism that produces a product alcohol. At least one of growth rate and fermentable carbon consumption of the microorganism is greater in the presence of the fatty acids... Agent: Butamax(tm) Advanced Biofuels LLC
20110312054 - Isolation and characterization of schizochytrium aggregatum cellobiohydrolase i (cbh i): The present invention provides for the isolation and characterization of the cbh1 gene from Schizochytrium aggregatum. In particular, the present invention provides for the nucleic acid and amino acid sequences of Schizochytrium aggregatum cbh1, and domains, variants and derivatives thereof. The present invention further provides for the heterologous expression of... Agent: Mascoma Corporation
20110312055 - Method of production of alcohol: The invention provides a process for producing alcohol from a cellulosic material, said process comprising: hydrolyzing said cellulosic material with an aqueous acid to produce a hydrolysate; extracting acid and water from said hydrolysate with a water-miscible organic extraction solvent to yield (a) a first aqueous acidic solution containing said... Agent: Weyland As
20110312056 - Plasma membrane isolation: e
20110312057 - Lipase-containing polymeric coatings for the facilitated removal of fingerprints: A substrate or coating is provided that includes a lipase with enzymatic activity toward a component of a fingerprint. Also provided is a process for facilitating the removal of fingerprints is provided wherein an inventive substrate or coating including a lipase is capable of enzymatically degrading of one or more... Agent: Toyota Motor Corporation
20110312058 - Polypeptides with xylanase activity,: Polypeptides with xylanase activity modified to increase bran solubilisation and/or xylanase activity. The modification comprises at least an amino acid modification i position 110 and may have further modifications of one or more amino acids in position 11, 12, 13, 34, 54, 77, 81, 99, 104, 113, 114, 118, 122,... Agent: Danisco A/s
20110312059 - Tau protease compositions and methods: Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules... Agent: Oligomerix Inc.
20110312060 - Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in... Agent:
20110312061 - Novel lactobacillus plantarum and composition containing the same: The present invention provides Lactobacillus plantarum CJLP56 KCTC 11402BP, a composition containing the Lactobacillus for treating intestinal diseases, and a composition containing the Lactobacillus for enhancing immunity.... Agent: Cj Cheiljedang Corp.
20110312062 - Photobioreactor system for mass production of microorganisms: A photobioreactor system for mass production of microorganisms is disclosed. Water with microorganisms suspended therein is sprayed through a nozzle to create droplets. These droplets have a high surface area to volume ratio enabling efficient light transfer and gas diffusion. The water may also be passed through channels between two... Agent:
20110312063 - method for harvesting algae: The present invention relates to a method for collecting algae from an algae containing aqueous solution. The method comprises first, providing an organic coagulant to said solution and mixing the formed solution. Subsequently, an inert inorganic clay material is provided with mixing to the solution for coagulating said algae. The... Agent: Neste Oil Oyj
20110312064 - Methods of removing oily stains from fabrics: Described are compositions and methods for removing oily stains from fabrics by treating the fabrics with cyclodextrins. Cyclodextrins can be added to the fabrics or generated in situ by converting a substrate of starch or dextrin with cyclomaltodextrin glucanotransferase.... Agent: Danisco US Inc.
20110312065 - Clearcoat containing thermoase c160 for easy-cleaning of insect body stains: A substrate or coating is provided that includes a protease with enzymatic activity toward a component of a biological stain. Also provided is a process for facilitating the removal of a biological stain is provided wherein an inventive substrate or coating including a protease is capable of enzymatically degrading of... Agent: Toyota Motor Engineering & Manufacturing North America, Inc.
20110312066 - Enzymatic preparation of plant fibers: A method of extracting fibers from decorticated plant bast skin involves pre-treating decorticated plant bast skin of a fiber plant with an aqueous solution containing trisodium citrate having a pH in a range of about 8-14 at a temperature of about 90° C. or less; and subsequently treating recovered fibers... Agent:
20110312068 - Dialysis device for separating nucleated cells in a biological sample from other constituents: A dialysis device to separate nucleated cells in a biological sample from smaller constituents, the dialysis device having a first channel for receiving the biological sample, a second channel, and, a plurality of apertures, wherein, the second channel is fluidically connected to the first channel via the apertures, the apertures... Agent: Geneasys Pty Ltd
20110312067 - Dialysis device for separating pathogens from a biological sample: A dialysis device to separate pathogens from a biological sample, the dialysis device having a first channel for receiving the biological sample, a second channel, and, a plurality of apertures, wherein, the second channel is fluidically connected to the first channel via the apertures such that the pathogens flow from... Agent: Geneasys Pty Ltd
20110312069 - Microvial with digital memory for storage of oligonucleotide specification data: An oligonucleotide microvial for an oligonucleotide dispensing apparatus, the microvial having a container for holding a volume of reagent, an integrated circuit with digital memory storing oligonucleotide data relating to specifications characterizing the oligonucleotides, and, electrical contacts for connection to a control processor in the reagent dispensing apparatus to provide... Agent: Geneasys Pty Ltd
20110312070 - Microfluidic device with pcr chamber for high rate of temperature change: A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a PCR chamber, and, a heater element for heating the nucleic acid sequences... Agent: Geneasys Pty Ltd
20110312077 - Loc device for electrochemiluminescent detection of target nucleic acid sequences in a fluid with calibration chamber containing probes designed to be non-complementary with any nucleic acid sequences in the fluid: A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having hybridization chambers containing electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for... Agent: Geneasys Pty Ltd
20110312075 - Loc device with parallel incubation and parallel dna and rna amplification functionality: A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material including DNA and RNA, a supporting substrate, a plurality of reagent reservoirs, a first incubation section, the first incubation section being in fluid communication with one... Agent: Geneasys Pty Ltd
20110312079 - Loc with digital memory to store epidemiological updates: A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry with digital memory for storing epidemiological data, and configured to download epidemiological data... Agent: Geneasys Pty Ltd
20110312078 - Microfluidic device for detecting target nucleic acid sequences in mitochondrial dna: A microfluidic device for detecting mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing mitochondrial DNA, a lysis section for lysing the mitochondria to release the mitochondrial DNA, probes for hybridization with target nucleic acid sequences... Agent: Geneasys Pty Ltd
20110312071 - Microfluidic device with large channels for cell transport and small channels suitable for biochemical processes: A microfluidic device for molecular diagnostic analysis of a biological sample containing cells, the microfluidic device having a supporting substrate, a plurality of microsystems technology (MST) channels each with a cross-sectional area between 1 square micron and 400 square microns for biochemical processing of constituents within the biological sample, and,... Agent: Geneasys Pty Ltd
20110312072 - Microfluidic device with surface micro-machined chips and interconnecting cap: A microfluidic device for diagnostic analysis of a sample fluid, the microfluidic device having a plurality of lab-on-a-chip (LOC) devices each having a supporting substrate and a microsystems technology (MST) layer for processing the sample fluid, and, a cap interconnecting the plurality of LOC devices, the cap having a cap... Agent: Geneasys Pty Ltd
20110312073 - Microfluidic test module incorporating surface micro-machined chips and interconnecting cap: A test module having a casing for hand held portability, a receptacle for receiving a sample fluid, and, a microfluidic device in fluid communication with the inlet, the microfluidic device having a plurality of lab-on-a-chip (LOC) devices and a cap in engagement with each of the plurality of LOC devices,... Agent: Geneasys Pty Ltd
20110312076 - Microfluidic test module with flexible membrane for internal microenvironment pressure-relief: A microfluidic test module having an outer casing for hand held portability, and, a microfluidic device mounted within the outer casing for processing a biological sample, the outer casing providing a microenvironment adjacent the microfluidic device, wherein, the outer casing has a membrane seal of flexible material between the microenvironment... Agent: Geneasys Pty Ltd
20110312074 - Microfluidic test module with sample receptacle: A test module having a receptacle for receiving an unprocessed biological sample through an opening, a cover movable between open and closed positions, the cover exposing the opening when in the open position and closing the opening when in the closed position, and, a microfluidic device for processing the biological... Agent: Geneasys Pty Ltd
20110312082 - Dispensing apparatus for wafer-scale dispensing of reagents: A reagent dispensing apparatus for loading reagents into a silicon wafer on which an array of lab-on-a-chip (LOC) devices are fabricated, each LOC device having a digital memory for data related to the reagents loaded into the LOC device, the reagent dispensing apparatus having a plurality of reagent vials each... Agent: Geneasys Pty Ltd
20110312080 - Porous films by a templating co-assembly process: A method of making a composite includes providing a particle suspension comprising colloidal particles (430) and a soluble matrix precursor (440); and co-depositing the particles and the matrix precursor on a surface in a process that provides a composite of an ordered colloidal crystal comprised of colloidal particles (430) with... Agent: President And Fellows Of Harvard College
20110312081 - Reagent dispensing apparatus for array of microfluidic devices: A reagent dispensing apparatus for loading reagents into a fixed array of microfluidic devices, each microfluidic device having a digital memory for data related to the reagents loaded into the microfluidic device, the reagent dispensing apparatus having a plurality of reagent vials each of the vials having an integrated circuit... Agent: Geneasys Pty Ltd
20110312083 - Composter for a garden: A composter having a downwardly open container (1) which stands on the ground (2) and has a filling opening which is arranged on the top side and can be closed by a lid (9). An unventilated upper chamber (10), which is arranged beneath the filling opening, opens laterally into a... Agent:
20110312084 - Use of a transparent composition for photobioreactors: c
20110312085 - In situ heat induced antigen recovery and staining apparatus and method: An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do... Agent:
20110312086 - Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure: The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and... Agent: Academisch Ziekenhuis Leiden
20110312087 - Bioreactor for the cultivation of mammalian cells: Large-scale bioreactors having at least two impellers, large-scale bioreactor systems and methods for the large-scale cultivation and propagation of mammalian cells using these bioreactors.... Agent:
20110312088 - Cd19 binding agents and uses thereof: This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.... Agent: Seattle Genetics, Inc.
20110312090 - Cardiomyocyte medium with dialyzed serum: Methods and composition for maintenance of cardiomyocytes are provided. For example, in certain aspects methods including culturing the cardiomyocytes in a medium essentially free of serum or containing dialyzed serum to maintain long-term purity. In further aspects, methods for modulation of cardiomyocytes may be provided.... Agent:
20110312089 - Process for cultivating cells: A process for cultivation of differentiated human cells retaining stem cell potential is provided. The process comprises culturing differentiated human cells retaining stem cell potential anchored to a microcarrier selected from the group consisting of gelatin microcarriers and quaternary ammonium derivatised polystyrene microcarriers.... Agent:
20110312091 - Pluripotent stem cells, method for preparation thereof and uses thereof: Human pluripotent stem cells which are isolated from cut human umbilical cord or placenta and characteristic of cell surface marker CD151+, OCT4+ and CD184−, can adhere to tissue culture plastic and have the potential to differentiate into three germ layers: endoderm, mesoderm and ectoderm. Methods of isolating, purifying and culturally... Agent:
20110312092 - Dual-terminal amide hydrogelling agent: Disclosed is a benzamide derivative represented by formula (1). In the formula, k1 represents an integer from 0-4, m1 represents an integer from 1-100, and n1 represents an integer from 1-6. In addition, R1 represents a hydrocarbon group with 8-22 carbon atoms bonded via an oxygen atom; R2 represents H... Agent:
20110312093 - Compositions and methods for prevention and treatment of amyloid-beta peptide-related disorders: The present invention provides methods and compositions for modulating levels of amyloid-β peptide (Aβ) exhibited by cells or tissues. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate Aβ levels. The invention also provides modulation of Aβ levels via selective modulation (e.g., inhibition) of ATP-dependent... Agent:
20110312094 - Use of double stranded rna to increase the efficiency of targeted gene alteration in plant protoplasts: Method for targeted gene alteration in protoplasts of plant cells comprising the steps of transiently transfecting the protoplasts with a dsRNA that preferably targets plant MMR mRNA; and a mutagenic nucleobase. The transfection may be simultaneously or subsequently and the gene can be any gene functional in the mismatch repair... Agent: Keygene N.v.
20110312095 - Method and constructs for increasing recombinant protein production in plants dehydration stress: The present invention provides methods and constructs for increasing recombinant protein production in plants during dehydration stress. The invention includes nucleic acids, inducible expression systems, and methods for using same for increasing recombinant protein production in plants and plant protection.... Agent: Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture12/15/2011 > 109 patent applications in 58 patent subcategories.
20110306033 - Biochemical processing apparatus: A biochemical processing apparatus is provided having a stage receiving a biochemical reaction cartridge which includes chambers and flow paths communicating therebetween, a moving system for moving liquid via the flow paths, and a detector for detecting the presence of the liquid in a chamber and/or the amount of the... Agent: Canon Kabushiki Kaisha
20110306032 - Device and method for diagnostic analyses: An integrated device for diagnostic analyses used to verify the presence of bacteria in at least a biological sample mixed with a eugonic culture medium in liquid form, to classify at least the type of bacteria, and to test a series of antibiotics, selected from a group of characteristic antibiotics... Agent: Alifax Holding Spa
20110306031 - Fluidic system for a flow cytometer: The fluidic system of the preferred embodiment includes a sheath pump to pump sheath fluid from a sheath container into an interrogation zone and a waste pump to pump waste fluid from the interrogation zone into a waste container. The sheath pump and/or the waste pump draw sample fluid from... Agent:
20110306038 - Assay for detection of human parvovirus nucleic acid: Nucleic acid oligomers specific for human parvovirus genomic DNA are disclosed. An assay for amplifying and detecting human parvovirus genotypes 1, 2 and 3 nucleic acid in biological specimens is disclosed. Compositions for amplifying and detecting the presence of human parvovirus genotypes 1, 2 and 3 genomic DNA in human... Agent: Gen-probe Incorporated
20110306034 - Method for isolating cells and disease vectors from bodily fluids: c
20110306035 - Methods and compositions for detection of a pathogen, disease, medical condition, or biomarker thereof: Provided are methods for detecting the presence or absence of a pathogen, disease, or medical condition, or biomarker thereof, using an enzymatic activity assay. In one embodiment, the method provided utilizes competitive inhibition of an enzyme for detecting a pathogen, disease, or medical condition, or biomarker thereof, in a subject.... Agent:
20110306037 - Oligonucleotuide probes and primers for detection of hepatitis b virus: The present disclosure provides a method for the detection and quantification of Hepatitis B Virus. It discloses oligonucleotide probes set forth in SEQ ID Nos. 1 and 2 for detection of Hepatitis B Virus along with respective primers [sense and antisense] set forth in SEQ ID Nos. 3, 4, 5... Agent: Bigtec Private Limited
20110306036 - Rt-lamp assay for the detection of pan-serotype dengue virus: The invention relates to a reverse transcription loop-mediated isothermal amplification (LAMP) assay for the detection of dengue virus. The assay is capable of simultaneous detection of dengue 1-4 serotypes in a single reaction.... Agent:
20110306039 - Apparatus for single-molecule detection: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector.... Agent: Industrial Technology Research Institute.
20110306040 - Cpg receptor (cpg-r) and methods relating thereto: The present invention is directed to nucleic acid molecules and polypeptides encoding a CpG receptor (CpG-R). The CpG-R contains a THD, interacts with the MyD88 adapter protein, and may bind to CpG oligonucleotides. The present invention is also directed to antibodies against CpG-R and to methods of modulating an immune... Agent:
20110306042 - Determination of chromatin conformation: Methods and kits for determining histone modification or epigenetic status are provided.... Agent: Bio-rad Laboratories, Inc.
20110306041 - Device for cell culture: A device for cell culture, in particular of neuronal cells, including: a substrate defining a first microfluidic chamber to be seeded with a first cell culture, and at least a second microfluidic chamber, a fluidic interconnection system connecting the first and second chambers and enabling cellular extensions, in particular axons,... Agent: Institut Curie
20110306048 - Bovine polymorphisms and methods of predicting bovine traits: Methods of predicting the phenotype of a trait in a bovine subject are provided. The methods include obtaining information about polynucleotide sequences specifically regarding the identity of the nucleotides present at one or more identified single nucleotide polymorphisms and using this information to make predictions regarding the trait in the... Agent: The Board Of Trustees Of The University Of Arkansas
20110306047 - Compositions and methods for rna hybridization applications: The invention provides methods and compositions for hybridizing at least one molecule to an RNA target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in RNA hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one nucleic... Agent: Dako Denmark A/s
20110306044 - Delta3, fthma-070, tango85, tango77, spoil, neokine, tango129, and integrin alpha subunit protein and nucleic acid molecules and uses thereof: The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins,... Agent: Millennium Pharmaceuticals, Inc.
20110306043 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles: The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.... Agent: The General Hospital Corporation
20110306045 - Method for confirming a diagnosis of rolandic epilepsy: A strong association between variants in Elongator Protein Complex 4, (ELP4) (specifically single nucleotide polymorphisms, SNPs) at the 11p13 locus on chromosome 11 and the centrotemporal sharp wave trait (CTS) has been discovered, which association has diagnostic significance for rolandic epilepsy. It has further been discovered that the 11p13 locus... Agent: The Hospital For Sick Children
20110306046 - Probes and primers for detection of malaria: The present disclosure gives description of a method used for the detection and quantification of malarial infection caused either by Plasmodium falciparum or Plasmodium vivax using nucleic acids isolated from blood samples by employing Oligonucleotide probes. The method employed here for detection is by Real time PCR.... Agent: Bigtec Private Limited
20110306053 - Amplification system with spatial separation: An automated nucleic acid analysis method and analytical system are described comprising separate modules, wherein the air flow of any one of said modules is controlled and wherein at least the air flow between the module for isolation and purification of the analyte and the module for analysis of the... Agent: Roche Molecular Systems, Inc.
20110306052 - Form-locking gripping system: The invention relates to an automated method of isolating and analyzing an analyte using a form-locking gripping mechanism. An analytical system comprising consumables and a handler, wherein the handler and consumable interact with a form-locking gripping mechanism are also included.... Agent: Roche Molecular Systems, Inc.
20110306050 - Method and apparatus for detecting specific dna sequences: An apparatus for detecting the presence of a microorganism in a sample includes a housing that includes a base fixed with a first DNA primer having a nucleotide sequence that is complementary to a DNA sequence of the microorganism of interest, a fibrinogen-splitting agent that is bound with a second... Agent: The Hong Kong Polytechnic University
20110306049 - Method for detecting gynecologic cancer: The object can be solved by a method for detecting gynecologic cancer characterized in that β1,3-galactosyltransferase-5 and/or β1,3-galactosyltransferase-4, and GlcNAc 6-O-sulfotransferase-2 are analyzed. According to the detecting method, ovarian cancer and endometrial cancer patients can be detected at an early stage i.e. stages I and II, wherein patients have no... Agent: Tokyo Institute Of Technology
20110306051 - Method for separating and detecting an analyte: A method for separating and analyzing an analyte is provided which comprises, in a first position, transferring a liquid sample to a multiwell plate with a pipette tip, replacing the tips in the tip rack in the same position, and re-using the pipette tips for aspirating and dispensing liquid.... Agent: Roche Molecular Systems, Inc.
20110306054 - Methods for molecular detection: This invention relates to methods for molecular detection, particularly to methods utilizing target-specific molecular probes. In exemplary embodiments, target-specific molecular probes include single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) aptamers. In general, the molecular probe may bind with relatively high specificity to a given target. In one aspect, a... Agent: Biotex, Inc.
20110306055 - Method for detecting metastasis of gi cancer: The present invention provides a novel method for diagnosing, monitoring, prognosing and staging Lymph Node (LN) status in colorectal cancer (CRC) that is more sensitive and accurate than conventional detection technologies such as histopathology. The Guanylyl Cyclase C (GCC) gene is specifically expressed in apical epithelial cells of the GI... Agent: Diagnocure Inc.
20110306056 - Method of identifying a. baumannii with oxa-131-like drug resistance in diabetic patients: A method for identifying A. baumannii with OXA-131-like drug resistance in diabetic patients includes the steps of obtaining a sample from a patient; identifying an isolate as A. baumannii; screening the isolate for genes encoding an OXA-51-like enzyme; sequencing any of the genes encoding an OXA-51-like enzyme; and identifying the... Agent:
20110306057 - Phosphorylated rala: Antibodies that are specific for human RalA that is phosphorylated at one or both of Ser183 and Ser194 are described as various methods such antibodies, including diagnostic methods and screening methods.... Agent: Dana-farber Cancer Institute, Inc.
20110306063 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Clusterin, Heart-type... Agent: Astute Medical, Inc.
20110306064 - Quantifiable internal reference standards for immunohistochemistry and uses thereof: Methods for identifying Quantifiable Internal Reference Standards (QIRS) for immunohistochemistry (IHC). Also disclosed are methods for using QIRS to quantify test antigens in IHC.... Agent: University Of Southern California
20110306065 - Use of an antibody and a rare-earth based crystal: The present invention provides compositions and methods for the detection of red blood cells antigens. The methods and compositions are based on antibodies, serving as primary antibodies or secondary antibodies, that are labeled with a rare-earth based crystal. Methods utilizing antibodies labeled with a rare-earth based crystal enhance the efficiency... Agent: The Trustees Of The University Of Pennsylvania
20110306059 - Compositions and methods for measuring 3,6-l-ahg transferase activity and 3,6-l-ahg: Provided herein are a composition for measuring 3,6-anhydro-L-galactose (3,6-L-AHG) transferase activity by reduction of NADP to NADPH, and a method of measuring 3,6-L-AHG transferase activity using the same. The composition and method are useful for determining 3,6-L-AHG in a material containing 3,6-L-AHG such as algae biomass and industrial applications.... Agent: Samsung Electronics Co., Ltd.
20110306058 - Method for the functional measurement of plasmatic thromboduline activity: A method for the in vitro measurement of the thromboduline functional activity, includes dosing in a biological medium, and from a biological sample, the thrombine-activation of C protein into activated C protein (PCa) in the presence of its co-factor or the thromboduline, the method including adding to the sample plasma... Agent: Diagnostica Stago
20110306060 - Pcsk9 immunoassay: Methods of using PCSK9 antagonists More specifically, methods for measuring circulating PCSK9 levels in a bio-logical sample by means of an immunoassay The immunoassay used can be a solid phase immunoassay, such as a dissociation-enhanced lanthanide fluorescence immunoassay utilizing an E07 capture antibody or coating and a G08 or H23... Agent:
20110306061 - Inhibitors of myelin-associated glycoprotein (mag) activity for regulating neural growth and regeneration: The present invention relates generally to products, compositions and methods useful for promoting neural repair and regeneration. The products and compositions of this invention include myelin-associated glycoprotein (MAG) derivatives that are inhibitors of endogenous MAG (e.g., mutant MAG proteins) and Nogo Receptor (NgR) binding inhibitors that are peptides derived from... Agent: Research Foundation Of City University Of New York
20110306066 - Homogeneous activity test for determining enzymatic reactions: A homogeneous method for determining the enzymatic activity of an analyte in a sample permits simultaneous determination of the amount of enzyme in the same reaction mixture and determination of enzyme activators or inhibitors.... Agent:
20110306062 - Babesia microti genomic clones containing novel antigens useful in the diagnosis of babesios: Disclosed are the cloning and expression of novel antigens in Babesia microti. The recombinant polypeptides are highly immunogenic. The polypeptides of the present invention provide the basis of a diagnostic assay that is sensitive, rapid and accurate using patient's sera. Also disclosed is an IgG and IgM ELISA using two... Agent: Medical Diagnostic Laboratories, LLC
20110306067 - Antibody profiles characteristic of tuberculosis state: Serum antibody assays capable of distinguishing cases of inactive TB from cases of active TB include a combination at least three M. tuberculosis protein antigens, at least one for which a positive response is consistent with inactive TB and antigens, and at least one for which a negative response is... Agent: University Of Medicine And Dentistry Of New Jersey
20110306069 - Corin as a marker for heart failure: The invention is a method of assessing whether an individual is afflicted with congestive heart failure (CHF) comprising comparing the level of corin or portion thereof in the individual to the level of corin or portion thereof in a control, wherein a decrease in the level of corin or portion... Agent:
20110306068 - Method for detecting and removing endotoxin: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins... Agent: Hyglos Invest Gmbh
20110306070 - Magnetic beads for reducing leukocyte interference in immunoassays: Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes in the sample to the magnetic sacrificial beads, and magnetically retaining the... Agent: Abbott Point Of Care Inc.
20110306071 - Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase: The invention provides assays and methods for determining the substrate specificity of gamma secretase inhibitors and for identifying substrate-selective (and substrate isoform-selective) inhibitors of gamma secretase. The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a site specific or substrate specific manner. The invention... Agent: Elan Pharmaceuticals, Inc.
20110306072 - Assay test card: The present invention relates to the use of surfaces that exhibit different surface energies wherein the difference in surface energies is configured to disrupt capillary laminar flow of a fluid travelling between the two surfaces The invention further relates to the use of such surfaces in assay methods including a... Agent: L3 Technology Limited
20110306074 - Glycosyltransferase reversibility for sugar nucleotide synthesis: The present invention generally relates to materials and methods for exploiting glycosyltransferase reversibility for nucleotide diphosphate (NDP) sugar synthesis. The present invention provides engineered glycosyltransferase enzymes characterized by improved reaction reversibility and expanded sugar donor specificity as compared to corresponding non-mutated glycosyltransferase enzymes. Such reagents provide advantageous routes to NDP... Agent: Wisconsin Alumni Research Foundation
20110306073 - Method and compositions for determining enzymatic activity and specificity of methyltransferases: The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyltransferases, methods of identifying potential substrates of O-methyltransferases, and methods of identifying potential inhibitors of methyltransferases.... Agent: The Salk Institute For Biological Studies
20110306075 - Methods related to modified glycans: Among other things, the present disclosure provides methods for enriching, identifying, and/or quantifying unusually modified glycans (e.g., phosphorylated glycans, sulfated glycans, and/or multi-acetylated glycans). In many embodiments, methods comprise providing a glycan preparation from which sialic acids have been released; subjecting the sialidase-treated glycan preparation to a separation technique that... Agent: Momenta Pharmaceuticals, Inc.
20110306076 - Cellobiose dehydrogenase: The present invention relates to cellobiose dehydrogenases (CDH) having glucose oxidation activity at a pH of 7.4 or above, modifications to modify the pH dependency of the enzymes activity, uses for these CDHs, in particular electrode sensors and electrochemical cells.... Agent:
20110306082 - \"benzoxazole-based fluorescent metal ion indicators\": Disclosed are benzoxazole-based compounds, kits, and methods of producing and using the described compounds in fluorescence-based detection of analytes (e.g., metal ions). Also disclosed are uses of benzoxazole-based compounds as ratiometric metal ion indicators.... Agent: Life Technologies Corporation
20110306080 - Determination of lamotrigine by mass spectrometry: The present invention relates to compositions and methods for analyzing analytes of interest in liquid samples by mass spectrometry, and preferably in patient samples. Preferred analytes of interest include sirolimus (rapamycin), corticosteroids, bile acids and lamotrigine (lamictal). In one embodiment, by careful selection of target ions, a number of corticosteroids... Agent: Quest Diagnostics Investments Incorporated
20110306078 - Method for quantitative transfer of analytes: A method for transferring a quantity of analytes comprising at least stages of: predisposing a substantially homogeneous mixture of a predetermined initial quantity of at least an analyte and a liquid, obtaining a known concentration value or known amount of the analyte in the mixture; introducing into the mixture at... Agent: Copan Italia S.p.a.
20110306077 - Methods for the detection of alternative cellular energy (ace) pigments and for monitoring of the ace pathway in the diagnosis and therapy of diseases: Ultraviolet light reactive alternative cellular energy pigments (ACE-pigments) are produced in response to certain chronic viral infections, metabolic disorders and degenerative illnesses. The pigments will display differing responsiveness to direct ultraviolet (UV) light illumination in the presence and in the absence of certain triggering dyes, including neutral red. The type... Agent:
20110306081 - Microfluidic device: The invention relates to a microfluidic device including a chamber having a fluid inlet, a fluid outlet and a sealable port. In some embodiments, the fluid inlet and the fluid outlet may be positioned to direct fluid flowing from the fluid inlet to the fluid outlet through the chamber. Various... Agent:
20110306083 - Salt selection of microbial mutants to increase bioproduct tolerance, titer, or osmotic shock tolerance: Methods are provided for selecting microbial strains with improved properties for fermentation and/or bioproduct production. A salt selection is employed to identify mutants with improved bioproduct tolerance, titer, or osmotic tolerance relative to a microbial strain from which they were derived.... Agent: Cobalt Technologies, Inc.
20110306084 - Tritiated planar carbon forms: Tritiated planar carbon forms and their production are provided. Methods are provided for the stoichiometrically controlled labeling of planar carbon forms capitalizing on normal flaws of carboxylic acids ubiquitously present in commercial preparations of these planar carbon forms. Alternative methods include generation of a metallated intermediate whereby a metal is... Agent: Perkinelmer Health Sciences, Inc.
20110306079 - Water-dispersable nanoparticles: Provided herein are methods for making water-soluble nanoparticles comprising a core/shell nanocrystal that is coated with a surface layer comprising enough hydrophilic ligands to render the nanoparticle water soluble or water dispersable. Methods for crosslinking molecules on the surface of a nanoparticle, which methods can be used on the above... Agent:
20110306087 - Apparatus to analyze a biological sample: An apparatus to analyze a biological sample contained in a container, comprising an examining device able to perform an optical measurement on the biological sample, based on light-scattering technology, at least of the bacterial growth in the biological sample. The examining device is provided with emitter means able to emit... Agent: Alifax Holding Spa
20110306086 - Cell separating method: The present invention provides a cell separating method including a step (S3) of determining the characteristics of a cell labeled with a caged compound; a step (S4) of activating the caged compound labeling a target cell by emitting light only to the target cell having a predetermined characteristic; and a... Agent: Sony Corporation
20110306085 - Compositions and methods for degrading lignocellulosic biomass: The present invention relates to compositions and methods of producing bioenergy products and metabolites of industrial interest from lignocellulosic biomass. More specifically, the invention describes the identification, characterization and isolation of novel bacteria having the remarkable ability to transform lignocellulosic biomass into fermentable sugars and, even more remarkably, into bioenergy... Agent: Deinove
20110306088 - Mini-reactor optimized channel sizing: A honeycomb body is disclosed having cells extending along a common direction, a first plurality of the cells being open at both ends of the body and a second plurality of the cells being closed at one or both ends of the body, the second plurality of cells arranged in... Agent:
20110306089 - Thermophilic methanogenic consortium for conversion of cellulosic biomass to bioenergy: A system for the efficient conversion of plant biomass to methane is provided, where the conversion includes use of a thermophilic methanogenic consortium containing a cellulolytic thermophile, an acetate-oxidizing thermophile and a thermophilic methanogen, the combination of which hydrolyzes hexoses and pentoses, oxidizes acetate and provides a hydrogen sink, to... Agent:
20110306092 - Expression vector system comprising two selection markers: wherein the activity of the selectable marker (sm I) or (sm II) is at least partially influenced by the activity of the other selectable marker and wherein the selectable markers (sm I) and (sm II) are involved in the folate metabolism. Also provided are suitable host cells, selection methods and... Agent: Novartis Ag
20110306091 - Lantibiotic biosynthetic gene clusters from a. garbadinensis and a. liguriae: This invention relates to characterisation of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine, a novel actagardine variant, herein referred to as actagardine B, and variants of both of these produced... Agent: Novacta Biosystems Limited
20110306090 - Mammalian expression vector: The present invention describes new mammalian expression vectors comprising a novel combination of regulatory elements and one or more selection marker gene(s). The vector allows for incorporation of at least one, preferably two or more genes of interest, its/their subsequent expression, and for selection of transfected cells using, e.g., G418... Agent: Lek Pharmaceuticals D.d.
20110306093 - Intergenic regions as novel sites for insertion of hiv dna sequences in the genome of modified vaccinia virus ankara: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.... Agent:
20110306094 - Method for obtaining immunoglobulin encoding nucleic acid: The current invention is directed to a method for obtaining a nucleic acid encoding an immunoglobulin variable domain from a single cell comprising the following steps:—performing a first polymerase chain reaction with three to six 5′-primer and one 3′-primer, performing with the product of the first polymerase chain reaction a... Agent:
20110306096 - Biotinylation tag peptides: Biotinylation peptides are provided which can be fused with other peptides or proteins of interest using recombinant DNA techniques to provide efficient methods for biotinylating the resulting fusion proteins in vivo or in vitro.... Agent: Pacific Biosciences Of California, Inc.
20110306097 - Multiwell plate and lid: The present invention relates to a multiwell plate for amplification and a lid with a foil for sealing the multiwell plate, wherein two positions of said lid on said plate exist, one position for storage, one position for sealing of the foil to the plate. The invention also relates to... Agent: Roche Molecular Systems, Inc.
20110306098 - Compositions and methods for use in isolation of nucleic acid molecules: The present invention relates generally to recombinant genetic technology. More particularly, the present invention relates to compositions and methods for use in selection and isolation of nucleic acid molecules. The invention further relates to methods for the preparation of individual nucleic acid molecules and populations of nucleic acid molecules, as... Agent: Invitrogen Corporation
20110306099 - Method of cloning dna: The present invention relates to a method for cloning double-stranded DNA (ds DNA) molecules. In particular, the present invention relates to a method for cloning ds DNA molecules using terminal transferase to tail at least one 3′ termini of the ds DNA molecules with nucleotides and ligating the tailed ds... Agent:
20110306101 - method of producing fatty acids for biofuel, biodiesel, and other valuable chemicals: A method of producing fatty acids, by: (i) inoculating in a first bio-reactor a mixture of at least one of cellulose, hemicellulose, and lignin with a microorganism strain that produces one or more cellulases, hemicellulases, and/or laccases that hydrolyze at least one of cellulose, hemicellulose and lignin, and culturing the... Agent:
20110306102 - Improved methods for fermentative production of docosahexaenoic acid: The invention comprises a process of producing polyunsaturated fatty acids from Thraustochytriales at high availability of oxygen by solid state fermentation or submerged fermentation in a batch, semi-continuous or continuous mode. Batch fermentation of more than 200 g/L and up to 450 g/L of dextrose added right in the beginning... Agent: V. B. Medicare Pvt. Ltd.
20110306100 - Method of producing fatty acids for biofuel, biodiesel, and other valuable chemicalspct/: The present invention relates to a method of producing fatty acids, by (i) inoculating a mixture of at least one of cellulose, hemicellulose, and lignin with at least one microorganism strain that produces one or more cellulases, hemicellulases and laccase, that hydrolyze at least one of cellulose, hemicellulose and lignin,... Agent:
20110306103 - Stabilization of perhydrolases: Disclosed herein is a method for stabilization of the perhydrolase activity of the CE-7 esterase in a formulation with a carboxylic acid ester that employs the addition of a buffering agent, substantially undissolved, to the mixture of the CE-7 esterase and the carboxylic acid ester. Further, disinfectant and laundry care... Agent:
20110306104 - Process for producing microbial fermentation product: as a substrate, bringing the dried product of the culture fluid into contact with such a solvent that the SP value of the medium obtainable after the contact between the dried product of the culture fluid and the solvent falls in the range of 9.5 to 16 [(cal/cm3)1/2], subsequently removing... Agent:
20110306105 - Engineering of yeast for cellulosic ethanol production: The disclosure provides designer cellulosomes for efficient hydrolysis of cellulosic material and more particularly for the generating of ethanol.... Agent: The Regents Of The University Of California
20110306106 - High expression promoter and method for producing gene product using same: Disclosed is a promoter which enables the expression of a gene product in a large quantity in Bacillus subtilis. Also disclosed is a method for producing a gene product using the promoter. Specifically disclosed are: a nucleic acid molecule which contains a promoter region derived from a toxin gene of... Agent: Otsuka Chemical Co., Ltd
20110306107 - Hardened mycelium structure and method: A method of preparing a mycelium component, including growing live mycelium from a fungal inoculum and a liquid aggregate. The live mycelium is cured to terminate further mycelium growth and form a mycelium structure. Moisture is applied to the mycelium structure such that the mycelium structure is nearly fully saturated.... Agent:
20110306108 - Apparatus and method for living cell manipulation: The present invention provides a method and system for using eye-safe infrared energy from a Class I laser to manipulate cells in culture. The laser energy produces one or more phase boundary propulsion events, which generate hydrodynamic forces sufficient to manipulate cells at the focal point.... Agent:
20110306109 - Barriers for facilitating biological reactions: The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.... Agent: Northwestern University
20110306110 - Method for three-dimensional hierarchical cell co-culture: e
20110306111 - Redox polymers: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons... Agent: Abbott Diabetes Care Inc.
20110306112 - Substantially pure reverse transcriptases and methods of production thereof: The present invention provides substantially pure reverse transcriptases, which are preferably substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in synthesizing, amplifying or sequencing nucleic acid molecules, including through the use... Agent: Life Technologies, Inc.
20110306114 - Purification of vaccinia viruses using hydrophobic interaction chromatography: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in... Agent:
20110306113 - Scalable process for protein purification: The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography... Agent: Cytos Biotechnology Ag
20110306115 - Environmental remediation material and method of making same: An environmental remediation material and method for making the same which include processing an organic material to increase the internal surface and surface pore area thereof through pyrolysis, coating the pyrolyzed material with a non-polar substance to enhance the material's oleophilicity, and applying secondary processing treatments designed to optimize the... Agent: Eci Research And Development Company
20110306116 - Method for encapsulation of microparticles: A method for encapsulation of microparticles (e.g., fungal conidia), involving (i) suspending microparticles in an aqueous solution containing at least one sugar to form an aqueous suspension wherein the concentration of said sugar is about 0.1 to 10% w/v, and (ii) spray drying said aqueous suspension with a spray dryer,... Agent:
20110306117 - Methods for enzymatic decolorization of chlorophyll: The invention provides the invention provides compositions and methods for the enzymatic treatment (“bleaching” or “de-colorizing”) of chlorophyll-comprising compositions, e.g., algae preparations, chlorophyll-containing or chlorophyll-contaminated feeds, foods or oils, for example, vegetable oils, including oils processed from oilseeds, such as canola (rapeseed) oil or soybean oil, or oil fruits, such... Agent: Verenium Corporation
20110306120 - Assay device and methods: The present invention relates to the use of amphipathic polymers to enhance lateral flow and reagent mixing on assay devices. More specifically, the invention relates to use of an amphipathic polymer in assay methods including a device for determining the concentration of lipids in blood serum or plasma.... Agent: L3 Technology Limited
20110306118 - Consumable hardware coding system: An analytical system is disclosed which recognizes different types of consumables with an identical footprint based on a unique surface geometry of each consumable. The analytical system comprises stackers into which said consumables can be loaded either automatically or by the user. The stacker for one specific type of consumable... Agent: Roche Molecular Systems, Inc.
20110306119 - Systems and methods for monitoring the amplification and dissociation behavior of dna molecules: The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. The present invention in one embodiment provides a system that includes a microfluidic channel comprising a PCR processing zone and an HRTm analysis zone; and an image... Agent: Canon U.s. Life Sciences, Inc.
20110306121 - Device and method for photosynthetic culture: A device and system for growing of a photosynthetic culture is provided which employs one or a plurality of vertically disposed photopanels having interior cavities configured for holding liquid and the photosynthetic culture such as algae. Interior surfaces are enhanced in size by projections defined by deformation in sidewalls of... Agent:
20110306122 - Hanging drop plate: A hanging drop plate and a method of cultivating cells or of producing molecular aggregates in at least one liquid volume that adheres to a drop contact area of such a hanging drop plate. The hanging drop plate has a body with a first surface and a second surface that... Agent: Universitat Zurich Prorektorat Forschung
20110306124 - Method for detoxifying a biological tissue: Biological tissues may be prepared for use in biological prostheses. The biological tissue may be fixated with glutaraldehyde and may be subjected to successive treatment of the tissue with a solution containing taurine to neutralize excess aldehyde groups that remain free after fixation.... Agent: Sorin Biomedica Cardio S.r.l.
20110306123 - Method for preparing biological tissues for use in biological prostheses: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with... Agent: Sorin Biomedica Cardio S.r.i.
20110306125 - Protein expression methods: The present invention relates to compositions and methods for obtaining (e.g., expressing, isolating and/or purifying) polypeptides capable of binding to and/or activating the guanylate cyclase C receptor.... Agent: Ironwood Pharmaceuticals, Inc.
20110306126 - Method for producing antibody directed against protein expressed on cell surface: Specifically disclosed is a means for obtaining a desired antibody by mixing cells capable of expressing an antigen protein on the surfaces thereof (i.e., antigen molecule-expressing cells) with an antibody library composed of antibody-expressing cells, viruses or the like, and subsequently concentrating/isolating only components (e.g., antibody-expressing cells, viruses) capable of... Agent: Chiome Bioscience Inc.
20110306127 - Enhancing iron uptake in protein-free media: Methods for enhancing iron uptake in cell culture are described. The methods include using a NTBI uptake activator and non-protein bound iron source. Suitable NTBI activators are delineated. Also described are serum-free culture media which can be used in the present methods.... Agent: Empire Technology Development LLC
20110306128 - Culture of cells: The invention relates to a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) cells on a lectin. The invention relates also to the use of a lectin in a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) celts and a... Agent: Suomen Punainen Risti Veripalvelu
20110306130 - Induction of pluripotent stem cells into mesodermal lineages: The present invention provides a method of inducing mesoderm derived cells from pluripotent stem cells. In contrast to methods known in the art that are often designed to replicate in vivo events of mesoderm induction, the present invention provides a unique, yet simple, method whereby pluripotent stem cells are mesodermally... Agent:
20110306131 - Induction of pluripotent stem cells into mesodermal lineages: The present invention provides a method of inducing mesoderm derived cells from pluripotent stem cells. In contrast to methods known in the art that are often designed to replicate in vivo events of mesoderm induction, the present invention provides a unique, yet simple, method whereby pluripotent stem cells are mesodermally... Agent:
20110306129 - Stem cell growth media and methods of making and using same: The invention provides media formulations. A complete media formulation of the invention includes, for example, the following components: albumin, an iron carrier, glutamine, a glycosidase or hydrolase, fibroblast growth factor (FGF), a salt or mineral, and essential amino acids at an osmolarity of about 220-330 mOsm/Liter.... Agent:
20110306133 - Culture medium and method for inducing differentiation into adipocytes: Disclosed are a culture medium, an additive, and a method for efficiently inducing the differentiation of mammalian somatic stem cells into cells having the characteristics of adipocytes under conditions of serum-free or low-serum culture medium. The culture medium for inducing the differentiation of mammalian somatic stem cells into adipocytes comprises... Agent:
20110306132 - Culture medium and method for inducing differentiation into bone cells: Disclosed are a culture medium, an additive, and a method for efficiently inducing the differentiation of mammalian somatic stem cells into cells having the characteristics of bone cells under conditions of serum-free or low-serum culture medium. The culture medium for inducing the differentiation of mammalian somatic stem cells into bone... Agent: Fujirebio Inc.
20110306135 - Method for producing tooth: A method for producing a tooth having a desired length in one direction includes the steps of: placing a first cell aggregate and a second cell aggregate in the inside of a support while bringing the first and the second cell aggregates into close contact with each other; and culturing... Agent: Organ Technologies, Inc.
20110306134 - Retention of a stem cell phenotype: A method for promoting the retention of a stem cell phenotype in a population of stem cells. A biocompatible substrate is provided, e.g. in the form of cultureware. The substrate has an arrangement of topographical features arrayed in a pattern based on a notional symmetrical lattice in which the distance... Agent:
20110306136 - Laminin-entactin complex and cell culture article and methods thereof: A cell culture system including: a substrate, a substrate coating, one or more live cells, and an overlay source. The substrate coating and overlay can be laminin, and laminin•entactin complex, respectively. Alternatively, the substrate coating and overlay can be laminin•entactin complex, and laminin, respectively. The cell culture system can further... Agent:
20110306138 - Complex and method for enhancing nuclear delivery: The use of at least one nucleic acid based nuclear localization signal including a natural or synthetic m3G-CAP is shown to increase transmembrane transport of a molecular cargo, in particular large molecules, into the nucleus. The use of natural and synthetic m3G-CAP is disclosed and the effect shown with a... Agent:
20110306137 - Methods and compositions for modulating differentiation of pluripotential cells: Methods and compositions useful for altering the differentiation potential of marrow adherent stromal cells, also known as mesenchymal stem cells are disclosed. The normal tendency for these cells to differentiate into osteogenic and adipogenic lineages is restricted.... Agent:
20110306139 - Mutant cells suitable for recombinant polypeptide production: A mutated bacterial cell producing at least one heterologous polypeptide of interest, wherein said cell has a reduced expression-level of a polypeptide comprising an amino acid sequence at least 70% identical to the sequence shown in SEQ ID NO: 2, when compared with an otherwise isogenic but non-mutated cell; methods... Agent: Novozymes A/s12/08/2011 > 106 patent applications in 59 patent subcategories.
20110300529 - Detection of ifi16 in body fluids: The present invention relates to methods for the qualitative and/or quantitative determination of interferon inducible protein 16 (IFI 16) in an extracellular form.... Agent: Notopharm Srl
20110300530 - In vitro test system for viral infections: The invention relates to a multi-layered biological in vitro tissue containing: dermis layer, containing a collagen biomatrix with fibroblasts embedded therein and epidermis layer, containing epithelial cells. It is provided that latently virally infected neuronal cells are integrated at least into the dermis layer.... Agent: Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.
20110300531 - Method and device to detect the presence of analytes in a sample: Disclosed are methods and apparatus useful for determining the presence or absence of one or more analytes in a liquid sample, such as a biological or environmental sample. In some embodiments, the method can use an indirect competitive immunochromatographic test strip.... Agent: Agdia
20110300528 - Methods for bacteriophage design: Methods for designing and breeding phages are described. The methods include methods to design phages for previously resistant bacterial strains. The methods described do not use genetic manipulation techniques.... Agent:
20110300534 - Compositions and methods for sequencing nucleic acids: Embodiments relate to methods of sequencing nucleic acids. Embodiments encompass the use of nucleotide analogs and a nucleic acid polymerase enzyme or enzyme complex comprising proofreading activity. The nucleotide analogs may become incorporated into a replicating strand and induce the proofreading activity of the polymerizing enzyme, thereby prolonging the duration... Agent: Industrial Technology Research Institute
20110300532 - Control of the toxicity of gold nanoparticles: The present invention relates to gold nanocluster compounds, especially gold nanoparticles, having a reduced toxicity, especially cytotoxicity, which are preferably appropriate for use in medical diagnostics such as medical imaging (e.g. X-ray, CT etc.), said gold nanocluster compounds comprising a core of at least one gold atom and at least... Agent:
20110300533 - Yeast screens for treatment of human disease: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein... Agent: The University Of Chicago
20110300538 - Bifidobacteria crispr sequences: The invention relates to CRISPR sequences found in bifidobacteria and their uses.... Agent: Danisco A/s
20110300536 - Gene marker and method for detection of oral cancer: A gene marker for the detection of oral cancer, comprising methylated CpG sites in target genes, is provided. The CpG sites in the target genes are selected from a group consisting of the following CpG sites: FLT4_E206_F, ASCL1_E24_F, KDR_E79_F, TFPI2_P9_F, TERT_E20_F, ADCYAP1_P455_R, MT1A_P49_R, and combinations thereof. A method for the... Agent: China Medical University
20110300539 - Method for detecting polymorphism at nucleotide position -1639 of vkorc1 gene, and nucleic acid probe and kit therefor: A probe for detecting a polymorphism at position −1639 of the VKORC1 gene, the probe comprising an oligonucleotide having a nucleotide sequence having a length of 10 to 50 nucleotides, which nucleotide sequence comprises the nucleotides 80 to 89 of SEQ ID NO:1 or 2 and has a homology to... Agent: Arkray, Inc.
20110300535 - Method of identifying individuals at risk of thiopurine drug resistance and intolerance: The invention relates to methods and kits for identifying individuals at risk of thiopurine drug intolerance based on detecting the presence of mutations in the TPMT gene promoter associated with thiopurine drug resistance or intolerance.... Agent: University Of Otago
20110300540 - Methods and probe combinations for detecting melanoma: The present invention is based on the discovery of methods and combinations of probes to chromosomal regions that are gained or lost or imbalanced in melanoma that provide highly specific and sensitive assays for the detection of melanoma cells.... Agent: The Regents Of The University Of California
20110300537 - Methods of detecting sequence differences: The invention relates to methods of genotyping single nucleotide differences in a nucleic acid sample. More particularly, the invention provides methods of identifying the nucleotide at a polymorphic site or a group of polymorphic sites in a sample of genomic DNA. The method uses tagged primer extension in which a... Agent: Primeradx, Inc.
20110300541 - Detection and typing of bacterial strains: Methods for the detection and typing of bacterial strains from food products and dietary supplements, environmental samples, in vivo/in vitro samples, and for studying the natural diversity of the species are disclosed. Potential applications also include product development and/or detection and differentiation of new bacterial strains.... Agent:
20110300544 - Enhanced taqman probe based amplification: The present invention relates to the field of amplification and detection. In particular, the invention relates to methods for assaying a sample for one or more nucleic acid targets in a single reaction based on target amplification using a polymerase with 5′ nuclease activity. The invention also provides probes and... Agent:
20110300548 - Gdf15 as molecular tool to monitor and enhance phenotypic stability of articular chondrocytes: The present invention relates to GDF15 as a molecular marker in in vitro assays determining phenotypic stability of articular chondrocytes and predicting the outcome of chondrocyte transplantation.... Agent: Universiteit Gent
20110300542 - Gene expression profiling for identification, monitoring and treatment of multiple sclerosis: The present invention provides methods of characterizing multiple sclerosis pr inflammatory conditions associated with multiple sclerosis using gene expression profiling.... Agent:
20110300547 - Method of utilizing the pts gene and anti-sense ads to increase patchouli alcohol content in artemisia annua l.: The invention relates to a method of utilizing the pts gene and antisense ads to increase patchouli alcohol content in Artemisia annua L. plants. Using transgenic Artemisia annua L. plants, the method of the invention consistently increases the patchouli alcohol content in those plants, thus laying down a solid foundation... Agent:
20110300546 - Method of utilizing the pts gene and rna interference of the ads gene to increase patchouli alcohol content in artemisia annua l.: The invention relates to a method of utilizing the pts gene and RNA interference of the ads gene to increase patchouli alcohol content in Artemisia annua L. plants. Using transgenic Artemisia annua L. plants, the method of the invention consistently increases the patchouli alcohol content in those plants, thus laying... Agent:
20110300543 - Methods for making induced pluripotent stem cells from mesenchymal stem cells: The invention is directed to methods for making iPS cells from Mesenchymal Stem Cells (MSCs). In certain aspects the methods comprise expression of Oct4 in MSCs, thereby converting the MSCs to iPS cells.... Agent: The Trustees Of Columbia University In The City Of New York
20110300545 - Primers for the rapid and specific detection of propane-oxidizing and butane-oxidizing microorganisms and methods of using same: Nucleic acid sequences are provided which in an embodiment provide a primer pair. The primers are capable of amplifying a nucleic acid molecule that indicates the presence of a propane-oxidizing and/or butane-oxidizing microorganism. A method is provided which employs such primers in a process that indicates the presence of such... Agent: Cal Poly Corporation
20110300549 - Treatment of development-related disorders: Disclosed are composition and methods for treating development-related disorders. Also disclosed are diagnosis methods, prognosis methods, and drug screening methods.... Agent:
20110300550 - Method for detecting nucleic acid in biological sample: The present invention provides a method for detecting a nucleic acid in a biological sample, comprising: (A) a step of mixing a biological sample with a nucleic acid stabilizer solution comprising a water-soluble organic solvent as an active ingredient, and thereafter preserving the thus yielded suspension for a predetermined period... Agent: Olympus Corporation
20110300551 - Method of predicting clinical outcomes for melanoma patients using circulating melanoma cells in blood: The present invention provides an automated method for capturing and detecting circulating melanoma cells (CMC's) in the blood of patients with melanoma. The absolute number of circulating melanoma cells detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression, and response... Agent:
20110300553 - Engineering complex microbial phenotypes with successive integrations of exogenous dna (siedna): The present invention relates to a recombinant E. coli exhibiting a complex phenotype, comprising three or more heterologous DNA fragments integrated into a chromosome of the recombinant E. coli bacterium. Also provided are methods for screening such a recombinant E. coli.... Agent: University Of Delaware
20110300552 - Systems and methods for determining drug resistance in microorganisms: The present invention is based on the discovery that drug resistance in microorganisms can be rapidly and accurately determined using mass spectrometry. A mass spectrum of an intact microorganism or one or more isolated biomarkers from the microorganism grown in drug containing, isotopically-labeled media is compared with a mass spectrum... Agent:
20110300554 - Exponential isothermal self-sustained replication of an rna enzyme: This invention provides nucleic acid molecules that catalyze their own replication and undergo exponential amplification at a constant temperature and in the absence of proteins or other biological components, such as those employed in other amplification reactions, e.g., proteins including DNA or RNA polymerase and a method of detect a... Agent: The Scripps Research Institute
20110300555 - Assay device comprising bubble-forming means: Disclosed is a method for determining the presence and/or amount Oran analyte of interest in a liquid sample comprising the steps of: contacting the liquid sample suspected of containing analyte with a gas generating means (eg. catalase and peracid or peroxygen compound), which gas generating means forms a gas dependent... Agent:
20110300559 - Compositions and methods for diagnosing and treating cancer and neurodegenerative diseases related to beclin-1: The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a... Agent: Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science
20110300560 - Novel members of the capsaicin/vanilloid receptor family of proteins and uses thereof: The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors... Agent: Bayer Schering Pharma Aktiengesellschaft
20110300561 - Method for identifying inhibitors of staphylococcus aureus: Provided are methods for identifying and/or designing inhibitors of Staphylococcus aureus biological activity. Also provided is a computer readable medium encoded with instructions executable by a CPU for performing the functions of identifying- or designing inhibitors of Staphylococcus aureus biological activity, and a system comprising the computer readable medium and... Agent: Indian Institute Of Science
20110300556 - Monoclonal antibodies detection methods for enzymes that confer resistance to 2,4-dichlorophenoxyacetic acid in plants: Described herein are monoclonal antibodies and methods useful for determining and quantitating the presence of an aryloxyalkanoate dioxygenase enzyme.... Agent: Dow Agrosciences LLC.
20110300557 - Methods for predicting pregnancy outcome in a subject by hcg assay: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin... Agent: The Trustees Of Columbia University In The City Of New York
20110300558 - Nanoparticle for bioaffinity assays: Thus this invention relates to a nanoparticle, useful for bioaffinity assays. The nanoparticle has a self-assembling shell built up of several protein and/or peptide subunits, which protein and/or peptide subunits can be of one or several different types, assembled in an organized manner to form the shell having an inner... Agent:
20110300564 - Diagnosis of pre-eclampsia: The present invention relates to a method of predicting pre-eclampsia (PE). The present invention also relates to a diagnostic kit for performing a method of predicting PE. In particular, the method determining the level of two or more markers selected from placenta growth factor (PlGF), plasminogen activator inhibitor-1 (PAI-1), plasminogen... Agent: Perkinelmer Las, Inc.
20110300562 - Gdf15 as a differential marker for spondyloarthropathy: In vitro methods for differential diagnosis of spondyloarthropathy are disclosed which involve determining the levels of GDF15 in biological samples.... Agent: Universiteit Gent
20110300563 - Methods of preparing and operating portable, point-of-care, user-initiated fluidic assay systems: Methods of preparing assays and of assaying, using substantially self-contained, portable, user-initiated fluidic assay systems. Example assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An assay system may... Agent: Boston Microfluidics
20110300565 - Analysis method, analysis device, program used to implement said analysis method, and storage medium and retrieval device for this program: An analysis apparatus includes a first analysis unit which collects samples by utilizing a first nozzle to analyze the sample, a second analysis unit which collects samples by utilizing a second nozzle to analyze the sample, and a transport apparatus which transports a plurality of sample vessels along a predetermined... Agent: Arkray, Inc.
20110300566 - Methods for screening for histone deacetylase activity and for identifying histone deacetylase inhibitors: The present invention relates to novel methods for screening for histone deacetylase enzyme activity in a test sample. The present invention further relates to novel methods for screening potential inhibitors of histone deacetylase enzymes.... Agent:
20110300567 - Method for determining redox activity and screening compounds based on redox activity: A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the... Agent: State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Portland
20110300574 - Cell-counting method for blood hemolysis analysis in fragility measurement: A method of using cell counting to determine how much hemolysis occurs when a sample of red blood cells is subjected to stress, for purposes of either assessing stored blood quality and/or obtaining red blood cell fragility profiles. Cell-counting techniques and technologies can be employed to facilitate and enhance fragility... Agent:
20110300569 - Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments: A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in... Agent: Acea Biosciences, Inc.
20110300571 - Determination of the liver toxicity of an agent: The present invention provides various biomarkers for hepatotoxicity and various methods of using the biomarkers Some of the biomarkers within the scope of this invention are cholate, glycochenodeoxycholate, glycocholate, taurine, 3-hyroxy-2-ethylpropionate, 4-imidazoleacetate, tyramine, anthranilate, 2′-deoxycytidine, N-acetyl aspartate (NAA), beta-hydroxy-hexanoate, and sarcosine (N-methylglycine) The methods of using the biomarkers include exposing... Agent:
20110300572 - In vitro method and apparatus for determining efficacy and action mechanisms of a topical composition on various skin color types: The present invention relates to in vitro methods for determining efficacy of topical compositions on various skin color types. These methods involve providing an artificial skin apparatus configured to approximate the color and diffuse reflectance characteristics of a predetermined human skin color type. The artificial skin apparatus includes an artificial... Agent: Integrated Botanical Technologies, LLC
20110300570 - Method and system for generating spatially and temporally controllable concentration gradients: The ability to rapidly generate concentration gradients of diffusible molecules has important applications in many chemical and biological studies. The present invention is directed to methods and systems for generating spatially and temporally controllable concentration gradients of molecules (i.e. proteins or toxins) in a portable microfluidic device. The formation of... Agent: The Brigham And Women's Hospital, Inc.
20110300573 - Method to characterize blood and red blood cells via erythrocyte membrane fragility quantification: A method for quantifying the quality degradation of individual stored red blood cell (RBC) units, thereby yielding information to improve decisions regarding their respective allocation, patient suitability, and use. The method comprises: a hemolysis step; an optical analysis step; and a computation step. The method is amenable to clinical implementation... Agent:
20110300568 - Systems and methods for processing algae cultivation fluid: Systems and methods for reducing an amount of unwanted living organisms within an algae cultivation fluid are provided herein. According to some embodiments, methods may include subjecting the algae cultivation fluid to an amount of cavitation, the amount of cavitation being defined by a pressure differential between a downstream pressure... Agent:
20110300575 - Cell-free system for synthesis of proteins derived from cultured mammalian cells: Prepared is an extract composition having an improved protein synthetic activity in a cell-free protein synthesis system using a mammalian cultured cell extract. An eukaryotic translation initiation factor and/or translational regulator are added to a cell-free protein synthesis system comprising an extract prepared from cultured mammalian cells and a template... Agent: Riken
20110300576 - T7 expression system: The present invention provides an improved prokaryotic cell expression system employing a tightly controlled host strain construct that controls uninduced, leaky expression of proteins while still auto-inducing well. Various aspects of the present invention address and overcome the problem of uninduced basal expression by providing a host strain that comprises... Agent:
20110300577 - Novel inhibitors of vascular endothelial growth factor activity, their uses and processes for their production: The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial... Agent: Genentech, Inc.
20110300578 - Novel inhibitors of vascular endothelial growth factor activity, their uses and processes for their production: The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial... Agent: Genentech, Inc.
20110300579 - Method of expressing proteins with disulfide bridges with enhanced yields and activity: Provided herein are methods for expressing proteins with disulfide bridges such as Vicrostatin (VCN), a chimeric variant of native snake venom disintegrin Contortrostatin (CN). The methods include what is believed to be a more efficient natural selection process that results in generating increased amounts of correctly-folded active conformers of proteins... Agent: University Of Southern California
20110300580 - Selection of host cells expressing protein at high levels: Described is a DNA molecule comprising an open reading frame sequence that encodes a selectable marker polypeptide, wherein the DNA molecule in the coding strand comprises a translation start sequence for the selectable marker polypeptide having a GTG start codon or a TTG start codon, and wherein the ORF sequence... Agent: Chromagenics B.v.
20110300581 - Process for producing difructose dianhydride iii crystals: A process for producing the crystals of difructose dianhydride III (DFA III), namely a indigestible disaccharide where two fructose molecules are bonded to each other at positions 1,2′ and 2,3′ (di-D-fructofuranose-1,2′:2,3′-dianhydride), where solutions containing DFA III are adjusted to and/or maintained at pH 5 or more, preferably pH 5 to... Agent: Nippon Beet Sugar Manufacturing Co., Ltd.
20110300582 - Corynebacteria strain having enhanced 5'-xanthosine monophosphate productivity and a method of producing 5'-xanthosine monophosphate using the same: Disclosed is a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type. Also, a recombinant vector which has the structure shown in the cleavage map of FIG. 1, a Corynebacteria strain transformed therewith, and a method of producing 5′-xanthosine monophosphate by culturing the transformed strain... Agent: Cj Cheiljedang Corporation
20110300583 - In vitro recombination methods using 5' exonuclease: Provided herein is a method for homologous end cloning using a 5′-exonuclease. One aspect provides a method of generating a recombinant DNA molecule comprising 5′ exonuclease digestion of DNA molecules, exonuclease inactivation, annealing of 3′ overhangs to form a annealed complex. Also provided is a method a method of generating... Agent:
20110300584 - Synthesis of fucosylated compounds: o
20110300585 - Systems and methods for altering rates of enzymatic processes: The various embodiments of the present invention relate generally to compositions, systems, and methods for altering rates of catalysis. More particularly, the various embodiments of the present invention are directed toward compositions, systems, and methods for enzymatic hydrolysis of polysaccharides, such as cellulose and starch. An aspect of the present... Agent: Georgia Tech Research Corporation
20110300586 - Two-stage process for biomass pretreatment: Described herein are improved methods of pretreating lignocellulosic biomass. One aspect of the invention relates to a two-stage pretreatment process comprising a relatively low severity steam treatment, a controlled pH pretreatment, or autohydrolysis, followed by hydrolysis with dilute acid or hot water at a relatively low temperature. In certain embodiments,... Agent:
20110300587 - Methods to degrade sludge from pulp and paper manufacturing: A method to degrade or digest sludge, such as from pulp and/or paper manufacturing, is described. Compositions to use in the method are further described.... Agent: Buckman Laboratories International, Inc.
20110300588 - Mutations and genetic targets for enhanced l-tyrosine production: The invention relates to identification of mutations and genetic targets for enhanced L-tyrosine production, and bacterial strains capable of L-tyrosine production.... Agent: Massachusetts Institute Of Technology
20110300589 - Novel microbial succinic acid producers and purification of succinic acid: The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in... Agent: Basf Se
20110300591 - Bacterial compositions of staphylococcus vitulinus having nitrate reductase activity and of lactic acid bacteria and methods using these compositions: The invention relates to a method for converting nitrates to nitrites and to specific compositions of bacteria belonging to the Staphylococcus vitulinus species optionally in association with lactic acid bacteria such as Lactococcus genus or Pediococcus genus and their use for developing the red color of a food product containing... Agent: Danisco A/s
20110300590 - Method for synthesizing an omega-amino acid or ester from a monounsaturated fatty acid or ester: The invention relates to a method for synthesizing ω-aminoalkanoic acids or esters thereof from unsaturated natural fatty acids, passing through a monounsaturated dinitrile intermediate compound. The method of the invention is simple to carry out and, compared to other known methods, avoids the environmental constraints and economic disadvantages due to... Agent: Arkema France
20110300592 - Method for producing poly-3-hydroxyalkanoic acid: When industrially separating and purifying poly-3-hydroxyalkanoic acid produced by a microorganism, to obtain poly-3-hydroxyalkanoic acid particles having an arbitrary volume mean particle diameter with favorable productivity and with decreased amount of an organic solvent used is enabled while decreasing contaminants derived from constitutive components of cellular bodies. According to the... Agent: Kaneka Corporation
20110300593 - Optimised fermentation media: The invention relates to improvements in the production of alcohols by microbial fermentation, particularly to production of alcohols by microbial fermentation of a substrate comprising CO. It more particularly relates to the provision of an inorganic organic sulfur source to a fermentation system such that one or more micro-organisms convert... Agent: Lanzatech New Zealand Limited
20110300594 - Process for making linear dicarboxylic acids from renewable resources: This invention provides a process of making a linear dicarboxylic acid of C10, C12, C14, C16 or C18 chain length, the process comprising providing a feed which is a renewable resource, contacting the feed with a catalyst in the presence of hydrogen and at a temperature of about 250° C.... Agent: E.i. Du Pont De Nemours And Company
20110300595 - Microorganism for producing succinic acid: The invention relates to an isolated, genetically modified microorganism, wherein compared to the wild type a) the idh1 and idp1 genes have been deleted or inactivated, and/or b) the sdh2 and sdh1 genes have been deleted or inactivated, and/or c) the PDC2 gene has been deleted or inactivated or is... Agent: Organo Balance Gmbh
20110300596 - Preparation method for alcohol from carboxylic acid by one-step process: The present invention relates to a preparation method for alcohol by reacting carboxylic acid, alcohol, and hydrogen using hydrogenation catalysts. More specifically, the invention relates to a method for preparing alcohol by performing esterification and hydrocracking in a one-step process using hydrogenation catalysts instead of a two-step process. According to... Agent: Sk Innovation Co., Ltd.
20110300597 - Microorganisms and methods for the biosynthesis of butadiene: The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.... Agent:
20110300598 - Device and method using integrated neuronal cells and an electronic device: The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same.... Agent: The Trustees Of The University Of Pennsylvania
20110300599 - Methods for improving the bioactivity characteristics of a surface and objects with surfaces improved thereby: The invention provides for a method of improving bioactivity of a surface of an implantable object. The invention also provides for a method of improving bioactivity of a surface of biological laboratory ware. The invention further provides a method of attaching cells to an object. The invention even further provides... Agent: Exogenesis Corporation
20110300602 - Conjugate preparation methods and related kit: Methods for preparing conjugates including enzyme conjugates and especially alkaline phosphatase (ALP) conjugates, and a kit are provided. The methods include: blocking an amino group on a molecule surface of a first substance to be conjugated containing an amino group and a carboxyl group (for example, an enzyme) with a... Agent: Shenzhen Mindray Bio-medical Electronics Co., Ltd.
20110300600 - Methods and compositions for delivering polynucleotides: Methods and compositions for delivering polynucleotides are provided. One embodiment provides a non-viral vector comprising a recombinant polynucleotide-binding protein comprising a protein transduction domain operably linked to a targeting signal. Methods for modifying the genome of non-nuclear organelles are also provided.... Agent: Gencia Corporation
20110300601 - Processes for synthesizing alkaline phosphatase conjugates: Methods for synthesizing an ALP conjugate are provided. The methods may include activating a carboxyl group of the ALP with a carbodiimide, to generate an active ester; and adding the substance to be conjugated such that a synthetic reaction occurs between the active ester and the substance to be conjugated,... Agent: Shenzhen Mindray Bio-medical Electronics Co., Ltd.
20110300603 - Tagged ligands for enrichment of rare analytes from a mixed sample: Method of enriching specific cells from cellular samples are disclosed, comprising contacting in solution a cellular sample with affinity-tagged ligands (ATLs) each comprising a first ligand linked to an affinity tag, wherein the ligand selectively binds a cellular marker of the rare cells and the affinity tag can be selectively... Agent: On-q-ity
20110300605 - Nanoscaling ordering of hybrid materials using genetically engineered mesoscale virus: The present invention includes methods for producing nanocrystals of semiconductor material that have specific crystallographic features such as phase and alignment by using a self-assembling biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to semi-conductor material. One form of the... Agent: Board Of Regents, The University Of Texas System
20110300604 - Recombinant influenza vectors with tandem transcription units: The invention provides a composition useful to prepare influenza viruses, e.g., in the absence of helper virus, using vectors which include tandem transcription cassettes containing PolI and/or PolII promoters.... Agent: Wisconsin Alumni Research Foundation
20110300606 - Formula of medium for culturing cordyceps spp.: A formula of medium for culturing Cordyceps spp. comprises 1˜6 wt % of carbon sources, 0.8˜51.5 wt % of nitrogen sources, 2˜12 wt % of alginate and 86.2˜95.2 wt % of solvent.... Agent:
20110300607 - System for treating blood of slaughtered animals and method for producing high-quality amino acid solution using blood of slaughtered animals: The present invention provides a system for treating the blood of slaughtered animals, the system comprising: a storage tank for collecting and storing the blood of animals slaughtered in a slaughter plant; a blood treatment tank in which the animal blood is received and stored from the blood storage tank... Agent: Hanshinn International Corp
20110300608 - Nucleic acid isolation in preserved whole blood: A method for isolating nucleic acids is disclosed, wherein a sample having nucleic acid containing starting material is fixed, lysed, and treated to remove unwanted contaminants. The initial fixing of the sample aids in maintaining the structure and integrity of the isolated DNA and reduces the incidence of end product... Agent: Streck, Inc.
20110300609 - Nucleic acid extraction apparatus: The present invention relates to a nucleic acid extracting apparatus, and the nucleic acid extracting apparatus can include a pipe-shaped tube having an open outlet at one side thereof, and a hydrogel supporting member that is provided inside the tube and filters impurities excluding an extraction target material.... Agent: Postech Academy-industry Foundation
20110300610 - Thermally conductive microplate: Embodiments according to the present teachings of a microplate comprising a main body portion having a first surface and an opposing second surface are disclosed. A plurality of wells are formed in the first surface, each of the plurality of wells being sized to receive an assay therein. A backing... Agent: Life Technologies Corporation
20110300611 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Lifeline Scientific, Inc.
20110300612 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Lifeline Scientific, Inc.
20110300613 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Lifeline Scientific, Inc.
20110300614 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Lifeline Scientific, Inc.
20110300615 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Lifeline Sciencetific, Inc.
20110300616 - Method for creating perfusable microvessel systems: A method for the creation of endothelial parent vessels from human vascular endothelial cells in vitro in a culture perfusion device (CPD) including a collagen chamber, inlet ports, a capillary tube, and an outlet port. A collagen solution is injected into the collagen chamber through a syringe needle until the... Agent: Nortis, Inc.
20110300617 - Biomass hydrothermal decomposition apparatus, temperature control method thereof, and organic raw material production system using biomass material: A biomass hydrothermal decomposition apparatus that feeds a solid biomass material 11 from one side of an apparatus body 42, feeds pressurized hot water 15 from the other side, to hydrothermally decompose the biomass material 11 while bringing the biomass material 11 into counter contact with the pressurized hot water... Agent: Mitsubishi Heavy Industries, Ltd.
20110300619 - In vitro determination of analyte levels within body fluids: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a... Agent:
20110300618 - Semi-automated device for single parameter and multi-parameter phenotyping of cells: A single-use device that produces a readily interpretable, visual presentation of biomaterial, enabling single parameter and multi-parameter characterizing of said biomaterial by means of visual inspection, particularly for immunophenotyping. In one embodiment, the device uses antibody coated microspheres which are adapted to bind to specific types of cells. An arrangement... Agent:
20110300622 - Apparatus and method for transporting sample well trays: An apparatus for transporting sample well trays with respect to a heating device is provided. The apparatus includes a sample well tray holder, a rotational actuator, and a biasing mechanism. The sample well tray holder includes a plate in which a sample well tray may be positioned. The sample well... Agent: Life Technologies Corporation
20110300620 - Combo-tip rack: The invention relates to a three-part rack for holding re-usable pipette tips. The rack comprises an upper, a lower and an insert rack. The rack is optimized for holding first and second types of pipette tips, and comprises contamination protection.... Agent: Roche Molecular Systems, Inc.
20110300621 - Process head positioning: A method is disclosed for mechanically aligning a process device and a rack which comprises mechanical engagement of positioning elements on the process device and positioning elements on the consumable.... Agent: Roche Molecular Systems, Inc.
20110300623 - Process for accelerated capture of carbon dioxide: The present invention generally relates to the removal of carbon dioxide from a gas stream, particularly a flue gas, hydrogen gas from a reformer, natural gas, or gas from a cement kiln. Immobilized enzymes for use in carbon capture and other systems are also disclosed.... Agent: Akermin, Inc.
20110300624 - Photobioreactor: A photobioreactor (100) comprises a base (110); a supportive frame (120) extending upwardly from the base; a plurality of trays (130) for culturing phototropic microorganisms, ranking vertically from a uppermost tray to a bottommost tray, supported co-axially on the supportive frame (120) and spaced apart one and other in a... Agent:
20110300625 - Tissue for prosthetic implants and grafts, and methods associated therewith: A prepared tissue for medical use with a patient is provided. Methods for preparing such tissue are also provided. Implantable tissue is provided by harvesting a tissue, such as but not limited to a pericardium tissue, and exposing the tissue to various cleaning, rinsing, treatment, separating, and fixation steps. The... Agent: Vela Biosystems LLC
20110300626 - Electrospun ceramic-polymer composite as a scaffold for tissue repair: The present invention relates to compositions and methods of preparing a three-dimensional matrix of micron sized electrospun fibers, wherein the electrospun fibers are formed from a electrospun composite comprising a bioactive ceramic component and a polymer component. The matrix provides an osteoconductive and osteoinductive scaffold supporting osteogenesis and thereby facilitates... Agent: New Jersey Institute Of Technology
20110300627 - Dedifferentiation and reprogramming of cells: The invention is directed to methods for reprogramming somatic cells to a less differentiated state. In particular, the invention is directed to methods for reprogramming amnion epithelial cells (AEC) including amnion-derived cells (ADC) and Amnion-derived Multipotent Progenitor cells (AMP cells) to a less differentiated state. The invention is further directed... Agent:
20110300628 - Enhancement of epidermal cell growth by non-protein growth factors: The serum-free culture of normal human epithelial stem cells is of paramount importance for the in vitro formation of cloned human tissues by means of cell therapy. Several growth promoting agents are disclosed for use in a serum-free culture medium of normal human keratinocytes. Lithium ions, dibutryl-cyclic adenosine monophosphate, and... Agent:
20110300629 - Trail trimers, methods and uses therefor: Disclosed are TNF-related apoptosis-inducing ligand (TRAIL) trimers (TR3) and nucleic acids encoding covalently linked TRAIL trimers. A TRAIL trimer can have greater stability compared to native TRAIL, and can retain the native killing ability of TRAIL. Target specificity of a TR3 can be shown by blocking its activity with soluble... Agent: Washington University
20110300630 - Methods for treating degenerative diseases/injuries: Invented is a method of treating degenerative diseases/injuries, in a mammal, including a human, in need thereof which comprises the administration of a therapeutically effective amount of a non-peptide TPO receptor agonist to such mammal.... Agent:
20110300631 - Method for suppressing cell growth: Disclosed is a method for suppressing the growth of a target cell, which is not limited in the type of a target cell and the type of a protein to be expressed in the target cell and needs not any preparatory experiment for determining a codon to be contained in... Agent: Japan Agency For Marine-earth Science And Technology
20110300632 - Method of directing the evolution of an organism: The present disclosure relates to a method of directing the evolution of an organism by modifying the mutation rate of an organism. The increase in genetic diversity may be used to facilitate the selection of a desired hereditary trait in an organism.... Agent: Neo-morgan Laboratory Incorporated
20110300633 - Novel promoter for use in transformation of algae: The objective of the present invention is to provide a transformation method that is applicable to a wide variety of species of algae with high efficiency. The promoter of the present invention is characterized in containing a polynucleotide constituting a non-coding region located upstream from a gene encoding a replication-associated... Agent:12/01/2011 > 112 patent applications in 62 patent subcategories.
20110294108 - System and method for an ex vivo body organ electrosurgical research device: The present disclosure is directed to a system and method for inflating and perfusing a body organ. The system and method includes a housing, a vacuum source, a perfusion pump and a temperature control module. The housing defines a cavity for containing an ex vivo body organ. In embodiments, the... Agent: Tyco Healthcare Group Lp
20110294113 - Detection device for detecting biological microparticles such as bacteria, viruses, spores, pollen or biological toxins, and detection method: A device for the detection of micro particles that can be marked by probes or antibodies capable of being detected by radiation has a filter, a supply system, and a detection system. Fluid to be examined is passed over a filter to filter out the micro particles and to perform... Agent: Eads Deutschland Gmbh
20110294111 - Method of determining and confirming the presence of an hpv in a sample: Methods are provided for genotyping a target nucleic acid in a sample. In various aspects, the methods comprise generating nucleic acid hybrids between probes specific for the genotypes of interest and the target nucleic acid and detecting hybridization in the sample. In other aspects, the methods comprise using multi-probe mixtures... Agent: Qiagen Gaithersburg Inc.
20110294109 - Methods for detecting an analyte: Methods of decreasing non-specific binding in solid phase assays for an analyte are disclosed. In the methods, the solid phase apparatus (lateral flow solid phase apparatus or capillary flow solid phase apparatus) is subjected to elevated heat. The elevated heat can be applied subsequent to application of a test sample... Agent:
20110294112 - Methods for point-of-care detection of nucleic acid in a sample: Provided herein are methods and apparatus for detecting a target nucleic acid in a sample and related methods and apparatus for diagnosing a condition in an individual. The condition is associated with presence of nucleic acid produced by certain pathogens in the individual.... Agent:
20110294110 - Set of magnetic labels: o
20110294115 - Method of determining the nucleotide sequence of oligonucleotides and dna molecules: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown... Agent: Arizona Board Of Regents
20110294116 - Methods and systems for direct sequencing of single dna molecules: The invention provides improved methods for sequencing nucleic acids, e.g., for medical applications and biomedical research. The disclosed methods can be applied to rapid personalized medicine, genetic diagnosis, pathogen identification, and sequencing species genomes.... Agent: The Regents Of The Unicersity Of California
20110294114 - Optimization of determinants for successful genetic correction of diseases, mediated by hematopoietic stem cells: Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for correction of a hematopoietic disease; in particular, in in vivo models. The invention also relates to modified lentiviral expression vectors for increase a viral titer and various methods for... Agent: Cincinnati Children's Hospital Medical Center
20110294125 - Colorimetric biosensor with allosteric dnazyme activation and rolling circle signal amplification: The present disclosure includes a method of determining the presence of a target in a sample comprising an allosteric DNAzyme; rolling circle amplification dependent on the activity of the allosteric DNAzyme in the presence of target and a detection system. The methods further comprise quantifying the amount of target in... Agent: Mcmaster University
20110294127 - Elite event a2704-12 and methods and kits for identifying such event in biological samples: Tools are provided which allow rapid and unequivocal identification elite event A207-12 in biological samples.... Agent: Bayer Bioscience N.v.
20110294126 - Kits and methods for assessing oxidative stress: The invention relates to kits and methods for assessing the susceptibility of a human to oxidative stress or damage. The methods involve assessing occurrence in the human's genome of one or more polymorphisms (e.g., single nucleotide polymorphisms) that occur in one or more genes associated with oxidative stress and that... Agent:
20110294124 - Method for the synthesis of phosphorus atom modified nucleic acids: Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.... Agent:
20110294121 - Methods and compositions for prognosing, detecting, and treating age-related macular degeneration: The invention provides methods and compositions for determining whether a subject is at risk of developing age-related macular degeneration, for example, the wet or neovascular form of age-related macular degeneration. The method involves determining whether the subject has a protective variant and/or a risk variant at a polymorphic site in... Agent: Massachusetts Eye And Ear Infirmary
20110294123 - Methods for diagnosing or treating prostate cancer: The present invention provides methods for detecting and/or diagnosing cancer through the determination of the expression level of the STC2 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer, methods... Agent: Oncotherapy Science, Inc.
20110294119 - Novel methods of differentiating yeast strains and/or determining genetic stability of yeast strains, and uses thereof: The invention relates to a method of determining the strain or strains of yeast in a sample, comprising: obtaining and screening nucleic acid from yeast for target sequences comprises all or part of a gene, or a flanking region associated with a gene, in the yeast mitochondrial DNA; and determining... Agent: The University Of Nottingham
20110294117 - Nucleic acid sequencing device and method of determining nucleotide sequence of target nucleic acid using the same: A nucleic acid sequencing device includes at least one nanochannel, a first electrode and a second electrode disposed at opposite ends of the nanochannel for applying a voltage in the lengthwise direction of the nanochannel, and a first detector that detects a location signal of a target nucleic acid passing... Agent: Samsung Electronics Co., Ltd
20110294120 - Probes for detection of sult1a1 gene, reagent containing the same, and the uses thereof: A primer set for amplifying a region including sites to be detected of SULT1A1*2 and SULT1A1*3 in the SULT1A1 gene by a gene amplification method is provided, wherein the primer set can amplify the region specifically. A pair of primer set is used including a forward primer consisting of the... Agent:
20110294122 - Synthesis of 2', 3'-dideoxynucleosides for automated dna synthesis and pyrophosphorolysis activated polymerization: Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.... Agent: Life Technologies Corporation
20110294118 - Water soluble fluorescent compounds: The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates.... Agent: Biosearch Technologies, Inc.
20110294131 - Analyzer, and control method for rotation of disc: The present invention has an object to provide an automatic analyzer using a disc, which treats samples with different pretreatment times or samples with different measurement times requested at random with high throughput. The present invention relates to performing adjustment rotation, rotation returning to origin, and measurement rotation in specimen... Agent:
20110294130 - Anti-cancer drug screening method using ror-alpha: The present invention relates to a method for screening an anticancer agent using RORα, the method comprising the steps of: culturing cells; bringing a potential substance into contact with the cells; determining whether the phosphorylation level of RORα in the cells increases as compared to that in control cells (not... Agent: Seoul National University Industry Foundation
20110294128 - Concentration and enrichment of microbial cells and microbial nucleic acids from bodily fluids: The present invention relates to a method for isolating microorganisms and/or microorganisms nucleic acids from a bodily fluid that may comprise or may be suspected to comprise microorganisms and/or host cells and/or host cells debris. Microorganisms nucleic acids may further be isolated by lysing the isolated microorganisms. The present invention... Agent: Universite Laval
20110294129 - Method for amplifying and/or detecting nucleic acids, kits and uses of said method: A method of amplification and/or of detection for removing contaminants in a liquid biological sample containing nucleic acids of interest to amplify, which includes treating the biological sample chemically or enzymatically to convert one type of base of the nucleic acids of interest to another type of base; adding amplification... Agent: Biomerieux
20110294132 - Method for archiving and clonal expansion: The present method provides methods, libraries, and kits related to the archiving and clonal expansion of sequences related to target polynucleotide sequences. The method allow for the attachment of polynucleotides with defined 3′ and or 5′ sequences to solid surfaces. The polynucleotides attached to the solid substrates can be stored... Agent: Nugen Technologies, Inc.
20110294133 - Methods for determining the presence or absence of elite event rf-bn1 in brassica plant material: This invention relates to transgenic winter oilseed rape (WOSR) plants, plant material and seeds, harboring a specific transformation event. It pertains to winter oilseed rape plants, more particularly to a pair of winter oilseed rape plants, which is particularly suited for the production of hybrid seed. More specifically, one plant... Agent: Bayer Bioscience, N.v.
20110294134 - Methods and kits for determining a risk to develop cancer, for evaluating an effectiveness and dosage of cancer therapy and for correlating between an activity of a dna repair enzyme and a cancer: Methods and kits for (i) determining a risk of a subject to develop cancer; (ii) evaluating an effectiveness and dosage of cancer therapy administered to a cancer patient; and (iii) determining a presence of correlation or non-correlation between an activity of at least one DNA repair enzyme and at least... Agent: Yeda Research And Development Co., Ltd.
20110294135 - Compositions and methods for analyte detection and quantitation: The present invention relates to methods and compositions useful for the detection and quantitation of analytes. The present invention has particular applicability to the detection and quantitation of analytes in samples of biological origin or that interact with biological systems.... Agent: Biodesic, LLC
20110294136 - Biomarker for diagnosing pancreatic cancer: The invention relates to a method for diagnosing pancreatic cancer (PaCa) or the precursor diseases and/or concomitant diseases thereof, in particular pancreatic ductal adenocarcinoma (PDAC), pancreatic intraepithelial neoplasia (PanIN), pancreatic lesions, chronic pancreatitis (CP), including endocrine pancreatic tumors. In said method, the diagnosis is performed using selected biomarkers. The invention... Agent:
20110294139 - Disposable chip-type flow cell and flow cytometer using same: The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell;... Agent: On-chip Biotechnologies Co., Ltd.
20110294140 - Lysis reagent for use with capture-in-solution immunoassay: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and non-specific animal immunoglobulins.... Agent: Abbott Laboratories
20110294138 - Methods for simultaneously measuring the in vivo metabolism of two or more isoforms of a biomolecule: The present invention encompasses methods for the simultaneous measurement of the in vivo metabolism of two or more isoforms of a biomolecule. The biomolecule is typically produced in the central nervous system.... Agent: The Washington University
20110294137 - Sensor: The invention relates to an ADP binding molecule comprising a polypeptide, said polypeptide comprising amino acid sequence corresponding to at least amino acids 11 to 310 of SEQ ID NO:1, wherein said polypeptide comprises a substitution relative to SEQ ID NO:1 at amino acid C287, and wherein said polypeptide comprises... Agent: Medical Research Council
20110294142 - Multiply fluorescently labeled calcium phosphate-protein surfaces: Described herein are multiply-fluorescently-labeled calcium phosphate protein substrates composed of a base coated with a fluorophore-labeled calcium phosphate coating and further having a fluorescently-labeled protein. The multiply-fluorescently-labeled substrate may be a fluorescently labeled calcium phosphate surface having a fluorescently-labeled collagen. The substrates are useful in culturing and studying the activity... Agent:
20110294143 - Method for detecting all haemophilus influenzae: Provided is an immunoassay method whereby all Haemophilus influenzae strains can be simultaneously detected at a high sensitivity. Specifically provided is a method for immunoassaying all Haemophilus influenzae strains characterized in that an antibody that recognizes P4 antigen or P6 antigen of influenza viruses is used.... Agent: Otsuka Pharmaceutical Co., Ltd.
20110294141 - Method for analyzing psa and method for distinguishing prostate cancer from prostatic hypertrophy using that method for analyzing psa: An object of the present invention can be solved by being brought into contact a lectin having an affinity for β-N-acetylgalactosamine residues and/or a lectin having an affinity for fucose α(1, 2) galactose residues with a sample possibly containing PSA, to determine an amount of PSA having an affinity for... Agent:
20110294146 - Identification of actinobacillus actinomycetemcomitans antigens for use in the diagnosis, treatment, and monitoring of periodontal diseases: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans.... Agent: University Of Florida Research Foundation
20110294145 - Reagents and methods for detecting a polymorphic protein: The present invention provides antibodies that differentially react with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein, proteins, cells, viral particles, compositions, and kits comprising same. The invention also provides methods for determining a haptoglobin type of a subject and methods for... Agent:
20110294144 - Screening method: The present invention provides a cell model system capable of sufficiently reproducing a series of tau lesions, and provides a screening method for a prophylactic or therapeutic drug for a neurodegenerative disease using phosphorylation, insolubilization or aggregation of tau, or neurite denaturation or cell death in the cell model as... Agent:
20110294147 - Serological screening for hhv-8 infection using antigen mixtures: The invention provides compositions, methods, and kits for the diagnosis or detection of active, latent, or prior infection with human herpesvirus 8 in a subject sample.... Agent: Government Of The U.s.a., As Represented By The Se Cretary, Department Of Health And Human Services
20110294148 - Tissue inhibitor of matrix metalloproteinases type-1 (timp-1) as a cancer marker and postoperative marker for minimal residual disease or recurrent disease in patients with a prior history of cancer: The present invention describes a method for determining whether an individual is suffering from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual. The present invention furthermore describes a method for determining whether an individual is suffering from minimal residual disease or recurrent... Agent: Rigshospitalet
20110294149 - Alzheimer's disease secretase, app substrates therefor, and uses therefor: The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates,... Agent: Elan Pharmaceuticals, Inc.
20110294150 - Immunoglobulin glycosylation pattern analysis: The current invention is directed to a method for the determination of the glycosylation pattern of a human immunoglobulin of the subclass IgG1 or IgG4 or of a murine immunoglobulin of the subclass Ig-G2a or IgG3 comprising the following steps: a) cleaving said immunoglobulin into fragments by enzymatic digestion with... Agent:
20110294152 - Calibration material delivery devices and methods: A device is described that includes: a first portion configured to be grasped by the hand of the user, and a second portion defining a reservoir containing a control material, wherein the control material contains a target analyte in a known or predetermined concentration. Related arrangements and methods are also... Agent: Intuity Medical, Inc.
20110294154 - Flow chamber and analyte detection method: A flow chamber and method for detecting the presence of one more cell produced analytes under flow conditions. The flow chamber includes two compartments separated by a permeable membrane on which a plurality of cells may be positioned. The permeable membrane shields one or more analyte sensors positioned one compartment... Agent:
20110294151 - Fluorescently labeled calcium phosphate surfaces: Described herein are substrates composed of a base coated with a fluorophore-labeled calcium phosphate coating. The substrates are useful in culturing and studying the activity of a variety of cells. The substrates described herein can be used for both solution- and image-based analysis of cultured cells. New methods for producing... Agent:
20110294157 - Method for modifying the properties of a fluid by irradiation, and system for implementing same: Methods for modifying the physical, chemical and/or biological properties of a fluid by irradiation are provided. In one embodiment, a method comprising supplying a flow of a fluid to an irradiation chamber; focusing the flow of the fluid so as to create at least one fluid layer; and applying radiation... Agent:
20110294155 - Modulation of an ion channel or receptor: This invention relates to a method of assaying a compound for its ability to modulate an ion channel or receptor type, the method comprising: a) providing a dynamic clamp in electrical contact with a biological cell (or part thereof) in which one or more ion channel or receptor types for... Agent: Howard Florey Institute
20110294153 - Reagent and method for detection of carboxylic acids by mass spectrometry: Method and reagent for converting a carboxylic acid to a positively charged amide. The method and reagent facilitate positive ion mass spectral analysis of carboxylic acids.... Agent: Washington, University Of
20110294158 - Rapid detection of bacteria using mass spectrometric analysis: Methods for the detection or diagnosis of a bacterial infection or colonisation utilising mass spectrometric analysis are provided. The methods involve short-term enrichment of samples followed by mass spectrometric analysis of biomarker profiles. Also provided are methods for preparing short-term enrichment cultures.... Agent: Northwick Park Institute For Medical Research
20110294159 - Biocompatible article for the treatment of water and production of energy: A biocompatible article including (a) a biocompatible hydrogel; (b) an adhesive coating on at least a portion of the hydrogel; and (c) one or more organisms adhered to at least a portion of the adhesive coating is disclosed.... Agent:
20110294160 - Cysteine protease autoprocessing of fusion proteins: Disclosed are fusion proteins, polynucleotides that encode the disclosed fusion proteins, and methods for expressing and autoprocessing of the disclosed fusion proteins to obtain a target protein. The disclosed fusion proteins include an autoproteolytic cysteine protease fused to a heterologous polypeptide, which may be isolated as the target protein. Preferably,... Agent: Northwestern University
20110294161 - Modified human growth hormone: Modified growth hormone polypeptide and uses thereof are provided.... Agent: Ambrx, Inc.
20110294162 - B-7 related nucleic acids and polypeptides useful for immunomodulation: The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated... Agent: Bristol-myers Squibb Company
20110294163 - Of enzymatic hydrolysis of pretreated lignocellulose-containing material with agricultural residues: A method for producing a fermentation product from a lignocellulose-containing material comprises pre-treating the lignocellulose-containing material; introducing agricultural residues to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to one or more hydrolyzing enzymes; and fermenting with a fermenting organism to produce a fermentation product. The agricultural residues may... Agent: Novozymes North America, Inc.
20110294166 - Thermostable enzymes for the hydrolysis of mannan-containing polysaccharides: The present disclosure relates to hydrolysis of mannan-containing poly- or oligo-saccharides by use of a polypeptide having endo-β-mannanase activity. In particular the present disclosure relates to compositions comprising a bacterial endo-β-mannanase, polynucleotides encoding the endo-β-mannanase, and methods of use thereof.... Agent: The Board Of Trustees Of The University Of Illinois
20110294164 - Variant humicola grisea cbh1.1: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are... Agent:
20110294165 - Variant humicola grisea cbh1.1: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are... Agent:
20110294167 - Nucleic acid amplification: The present invention provides improved systems and methods for amplifying nucleic acids. Among other things the present invention provides a system for amplifying nucleic acids through use of a primase and a polymerase with strand-displacement ability without, for example, exogenously-added primers. The present invention is particularly useful for whole genome... Agent: Kapabiosystems
20110294168 - Dna polymerases and related methods: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects of a variety of polymerase and reverse transcriptase inhibitors. Therefore, the mutant polymerases are useful... Agent: Roche Molecular Systems, Inc.
20110294169 - Lignocellulosic treatments and applications thereof: In one aspect, methods of treating lignocellulosic materials are described herein. In some embodiments, a method of treating a lignocellulosic material comprises degrading lignin of the lignocellulosic material with at least one fungus and hydrolyzing cellulose of the lignocellulosic material with at least one microorganism.... Agent:
20110294170 - Pentose fermentation by a recombinant microorganism: The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.... Agent: Codexis, Inc.
20110294171 - Preparation of a saturated aldehyde: wherein R1, R2 and R5 are each independently selected from H and hydrocarbon moieties, which hydrocarbon moieties optionally comprise one or more heteroatoms, and which hydrocarbons optionally comprise substituents, or when the compound according to formula (IX) is a salt, R1 and/or R2 may be a cation, R3, and R4... Agent: DsmIPAssets B.v.
20110294172 - Use of ionic liquids for implementing a process for the preparation of biodiesel: The use of a combination of—at least one ionic liquid which is lipophilic, and non miscible with water, and—at least one enzyme, for the implementation of an esterification and/or transesterification process of a substrate with at least one alcohol, the substrate consisting of oils, fats, fatty acids, or a mixture... Agent: Centre National De La Recherche Scientifique
20110294175 - Integrated process for the production of bio-oil from micro-organisms: The cultivation of heterotrophic and phototrophic micro-organisms is integrated for the production of bio-oil for biofuels, wherein the overall algal suspension produced is first thickened, with recirculation of the excess water to cultivation containers, and then thermally treated at a high temperature. After cooling, a bio-oil phase is recovered together... Agent: Eni S.p.a.
20110294173 - Process and microorganisms for production of lipids: e
20110294174 - Tailored oils produced from recombinant heterotrophic microorganisms: Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a lipase, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading... Agent: Solazyme, Inc.
20110294176 - Method of extracting butyric acid from a fermented liquid and chemically converting butyric acid into biofuel: Disclosed is a method of converting butyric acid contained in a fermentation broth into biofuel. This chemical conversion method includes separating biohydrogen from gases generated in the course of production of butyric acid through fermentation of carbohydrate, extracting butyric acid from the broth using an insoluble solvent, esterifying butyric acid... Agent:
20110294177 - Optimised fermentation media: The invention relates to improvements in the production of alcohols by microbial fermentation, particularly to production of alcohols by microbial fermentation of substrates comprising CO. It more particularly relates to the provision of an improved fermentation media, comprising nickel, to a fermentation system such that one or more micro-organisms convert... Agent: Lanza Tech New Zealand Limited
20110294178 - Method for the preparation of diols: e
20110294179 - Method for producing butanol using two-phase extractive fermentation: A method of making butanol from at least one fermentable carbon source that overcomes the issues of toxicity resulting in an increase in the effective titer, the effective rate, and the effective yield of butanol production by fermentation utilizing a recombinant microbial host wherein the butanol is extracted into specific... Agent: Butamax(tm) Advanced Biofuels LLC
20110294180 - Saccharomyces strain with ability to grow on pentose sugars under anaerobic cultivation conditions: The invention relates to an improved Saccharomyces strain displaying improved viability and growth during anaerobic fermentation of pentose carbon sources such as xylose and producing fermentation products such as ethanol.... Agent: C5 Ligno Technologies In Lund Ab
20110294181 - Process for the production of alcohol: The invention provides a process for producing alcohol from a cellulosic material, said process comprising the steps of: (i) hydrolyzing said cellulosic material with an aqueous acid to produce a hydrolysate; (ii) extracting acid and water from said hydrolysate with a water-miscible organic extraction solvent to yield (a) a first... Agent: Weyland As
20110294182 - Botryoccocus braunii triterpene synthase proteins and nucleic acid molecules, and methods for their use: This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are host cells comprising the nucleic acid molecules of this invention, proteins encoded by the nucleic acid molecules and methods for using the nucleic acid molecules,... Agent:
20110294184 - Cellulolytic polypeptides and their use in micro-organisms for the production of solvents and fuels: The invention relates to applications of a cellulase of Pseudomonas sp. ND137, functional fragments and/or variants and engineered forms thereof, in the context of industrial bioprocessing, more particularly solvent production.... Agent: L'universite De La Mediterranee
20110294183 - Modified host cells with efflux pumps: The present invention provides for a modified host cell comprising a heterologous expression of an efflux pump capable of transporting an organic molecule out of the host cell wherein the organic molecule at a sufficiently high concentration reduces the growth rate of or is lethal to the host cell.... Agent: The Regents Of The University Of California
20110294185 - Magnetic platforms for biomolecule trappings, manipulations, and sorting: A magnetic platform is provided and includes a patterned array of discrete magnetic elements positioned on a substrate, a plurality of first electromagnets for creating a first magnetic field substantially in the plane of the substrate, an electromagnetic coil for creating a second magnetic field substantially perpendicular to the plane... Agent:
20110294187 - Capturing particles: Methods and systems capturing particles suspended in a fluid flowed through a micro-channel, can include flowing the fluid including the particles to be captured through a micro-channel and past a groove defined in a surface of a wall of the micro-channel such that flowing the fluid past the groove forms... Agent: The General Hospital Corporation
20110294186 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles: The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.... Agent: On-q-ity, Inc.
20110294188 - Ideotypically modulated pharmacoeffectors for selective cell treatment: In a method embodiment, a method includes introducing a plurality of Ideotypically Modulated Pharmacoeffectors (IMP) into a population of cells. Each IMP may include a detection domain and an activation domain. One or more epitopes is bound by the detection domain. The activation domain is activated in response to the... Agent:
20110294189 - Biomolecule polymer conjugates and methods for making the same: Methods for producing biomolecule-polymer conjugates, such as polypeptide-polymer conjugates, include attachment of an initiator agent to a biomolecule and in situ polymerization of a polymer from defined sites on the biomolecule. The conjugates may have desirable pharmacological properties and may be used therapeutically.... Agent: Duke University
20110294190 - Mutant human superoxide dismutase 1 variants: The present invention in the art of biochemistry claims novel and non-naturally occurring engineered mutant “human superoxide dismutase 1” (hsod1) variant polypeptides, their encoding nucleic acids, and recombinant cells thereof. The inventor rationally engineered mutant hsod1 variants using structural observations and complimentary experimentation. The engineered mutant hsod1 variant products claimed... Agent:
20110294191 - Increased production of aspartic proteases in filamentous fungal cells: Described are compositions and methods relating to filamentous fungal cells genetically engineered to provide increased production of aspartic proteases, such as PEPAa, PEPAb, PEPAc, and PEPAd. Also described are nucleic acids and methods for making the engineered filamentous fungal cells.... Agent: Danisco US Inc.
20110294192 - Fusion collagenase in which affinity tag is linked and method for producing the same: A fusion collagenase in which an affinity tag is added to the carboxyl terminal of a collagenase was expressed as a recombinant protein. It was found that a collagenase having a collagen-binding domain can be selectively collected by purifying the obtained fusion collagenase by affinity chromatography.... Agent: Meiji Seika Pharma Co., Ltd.
20110294194 - Efficient cell culture system for hepatitis c virus genotype 2b: The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that... Agent: Hvidovre Hospital
20110294195 - Efficient cell culture system for hepatitis c virus genotype 7a: Genotype 7a has been identified recently, thus not much is known about the biology of this new, major HCV genotype. The present inventors developed hepatitis C virus 7a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding... Agent: Hvidovre Hospital
20110294193 - Viral vectors and methods for producing and using the same: A recombinant hybrid virus, including: (a) a deleted adenovirus vector genome comprising the adenovirus 5′ and 3′ cis-elements for viral replication and encapsidation, and further comprising a deletion in an adenovirus genomic region selected from the group consisting of: (i) the polymerase region, wherein said deletion essentially prevents the expression... Agent:
20110294196 - Methods and systems for producing lipids from microalgae using cultured multi-species microalgae: The present invention provides a system and method for culturing a microalgae biofamily to produce lipids. The method includes growing a microalgae biofamily comprises multiple microalgae species in a liquid medium at a first stress level. A portion of the microalgae are exposed to a second stress level and harvested.... Agent:
20110294198 - Disposable chamber for analyzing biologic fluids: An apparatus for analyzing biologic fluid is provided that includes first and second planar members, and at least three separators. At least one of the first planar member and second planar member is transparent. The separators are disposed between the planar members, and each individually has a height. The separators... Agent: Abbott Laboratories
20110294197 - Module for detecting analytes in fluids and chip having the same: Disclosed is a module for rapidly detecting analytes in fluids with high effectiveness and a chip having the module. The module includes a microchannel, which has a filtering zone for removing noise materials and a reaction zone wherein labeling reaction and immobilization reaction for detection of analytes are performed, sample... Agent: Digital Bio Technology Co., Ltd.
20110294199 - Apparatus for point-of-care detection of nucleic acid in a sample: Provided herein are methods and apparatus for detecting a target nucleic acid in a sample and related methods and apparatus for diagnosing a condition in an individual. The condition is associated with presence of nucleic acid produced by certain pathogens in the individual.... Agent:
20110294200 - Virtual separation of bound and free label in a ligand assay for performing immunoassays of biological fluids, including whole blood: Detection and characterization of immunologically detected substances are performed electronically on human and animal biological fluids such as whole blood, serum, plasma, urine, milk, pleural and peritoneal fluids, and semen, which fluids are contained in a thin chamber forming a quiescent fluid sample, which chamber has at least two parallel... Agent: Abbott Point Of Care, Inc.
20110294201 - Test device for liquids of the human or animal body: an in-feed area for feeding in a prescribed quantity of a bodily fluid, a reaction area connected downstream of the in-feed area and separated from the same by at least one closed separating wall, and in which the bodily fluid is brought to a chemical reaction with at least one... Agent:
20110294202 - Bioreactors with multiple chambers: A bioreactor for cultivating living cells in a liquid medium. In one embodiment of the present invention, the bioreactor has a first substrate having a first surface and an opposite second surface, defining a chamber therebetween for receiving the cells and the liquid medium. The bioreactor further has a barrier... Agent: Vanderbilt University
20110294203 - Cell washing: A cell cluster from which unwanted components are removed by efficiently washing the cell cluster is collected. Provided is a cell washing method including a centrifuging step (S1) of collecting a cell suspension in a centrifuge container having a washing fluid discharge port opposing a bottom part and centrifugally separating... Agent: Olympus Corporation
20110294204 - Expression system: The present invention relates generally to methods and compositions for expression of polypeptides or delivery of interfering RNAs in various cell types.... Agent:
20110294205 - Automated cellular material preparation: Provided are cartridges and systems for effecting automated extraction, isolation, and purification of cellular components—such as nucleic acids—from a cellular sample in assay-ready form. Also provided are related methods of effecting such sample processing.... Agent:
20110294206 - Methods and design of membrane filters: The present invention provides methods for designing a filtration systems for capturing viable tumor cells, such as circulating tumor cells at high efficiency and high viability. The methods involve development of a set of “key engineering design parameters” that are crucial to achieve high tumor cell viability. These important design... Agent: California Institute Of Technology
20110294207 - Spatially-defined modification of fresh tissue using covalent chemistry: Methods for modification of tissue using covalent chemistry. Tissue can be modified through direct alkylation, reduction followed by alkylation, or oxidation followed by condensation to covalently attach small organic molecules or appropriately modified proteins. The modification can be spatially limited to desired regions of the tissue surface.... Agent: Baylor University
20110294208 - Method and device for cell selection and collection in an isolated culturing environment: An apparatus for collecting or culturing cells or cell colonies has a common substrate and a plurality of cell carriers releasably connected to the common substrate. The carriers are arranged in the form of an array. The invention employs microcups as the cell carriers. The substrate is preferably free of... Agent:
20110294209 - Methods for producing nonadherent avian cell lines: The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the cells... Agent: Vivalis
20110294210 - Microcarriers for stem cell culture: We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50... Agent: Agency For Science, Technology And Research
20110294211 - Hepatocyte lineage cells: Disclosed herein are methods for producing liver precursor cells as well as hepatocyte cells form pluripotent and/or multipotent cells. Also disclosed herein are methods of enriching isolating and/or purifying liver precursor cells and/or hepatocyte cells. Further disclosed are compositions comprising cell cultures and cell populations that are enriched for liver... Agent:
20110294213 - 2'-arabino-fluorooligonucleotide n3'-p5' phosphoramidates: their synthesis and use: Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(═O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-aribino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic... Agent:
20110294212 - Methods of screening molecular libraries and active molecules identified thereby: The present invention provides a peptide having 2 to 10 amino acids or a derivative thereof which is able to restore wild type function of human p53, for use in therapy; and a method of screening a library of molecules for the ability of members of that library to restore... Agent:
20110294214 - Seeding cells on porous supports: The present invention generally relates to a method for seeding cells on to a support. In particular, the method relates to a method for seeding cells onto a porous hydrophobic support. The method utilizes centrifugal forces to uniformly guide cell seeding into the support with no loss in viability.... Agent:
20110294215 - Culture systems: A microplate is provided herein having a plate body with at least one well formed therein, the well having a first open end, a second end, an aperture being formed in the second end, and a side wall extending between the first end and the second end. The microplate further... Agent: Regenemed, Inc.
20110294216 - Sulfonylurea-responsive repressor proteins: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms... Agent: Pioneer Hi-bred International ,inc.
20110294217 - Dna nicking enzyme from a homing endonuclease that stimulates site-specific gene conversion: An engineered highly specific DNA-cleavage enzyme delivers a site-specific nick in a double stranded DNA, to cleave one DNA strand within its target site while leaving the opposing DNA strand intact. The engineered enzyme provides the ability to induce a gene conversion event in a mammalian cell. An engineered sequence-specific... Agent: Fred Hutchinson Cancer Research Center
20110294218 - Cd34-derived recombinant adeno-associated vectors for stem cell transduction and systemic therapeutic gene transfer: Novel adeno-associated virus (AAV) isolates in nucleotide and amino acid forms and uses thereof are provided. The isolates show tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the... Agent:
20110294219 - Use of the foamy virus bet protein for inactivating apobec: Described is the foamy virus Bet-mediated inactivation of the mutagenic, genome-modifying and vector-inactivating cellular enzyme ABOBEC. Such inactivation is useful for the treatment or prevention of various diseases, e.g., cancer, or for enhancing the production and genetic stability of gene therapy vectors, preferably retroviral vectors.... Agent:Previous industry: Education and demonstration
Next industry: Chemistry: analytical and immunological testing
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