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Chemistry: molecular biology and microbiology November recently filed with US Patent Office 11/11

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
11/24/2011 > 145 patent applications in 75 patent subcategories. recently filed with US Patent Office

20110287403 - Graft tensioning device: A graft tensioning device comprising a basin capable of containing a fluid, a heating element capable of heating the fluid to an appropriate temperature, a tray disposed within the basin, and a graft holding fixture for maintaining a tissue graft in tension, permanently or removably secured to the tray, wherein... Agent:

20110287404 - Stationary bubble reactors: Reactors that allow mixing and gasification by converting the entire floor of the reactor vessel to a sparge filter is described.... Agent: Therapeutic Proteins Inc.

20110287405 - Biomass production: There is provided a process of growing a phototrophic biomass in a reaction zone. The reaction zone comprises a production purpose reaction mixture that is operative for effecting photosynthesis upon exposure to photosynthetically active light radiation. The production purpose reaction mixture comprises production purpose phototrophic biomass that is operative for... Agent: Pond Biofuels Inc.

20110287409 - Diagnostic device and method: Diagnostic devices and methods involve comparison of relative levels of first and second components and/or characteristics of a fluid sample (e.g., saliva), preferably using bound antibodies arranged to interact with selected components, and colorimetric indicators that are released in proportion to relative concentration or amount of the components or characteristics,... Agent: Hydradx, Inc.

20110287410 - Hepatitis-c virus testing: New styles of hepatitis C virus (HCV), referred to as HCV-3 and HCV-4, have been identified and sequenced. Antigenic regions of HCV-2, HCV-3 and HCV-4 polypeptides have been identified. Immunoassays for HCV and antibodies thereto are described, which allow more complete screening of blood samples for HCV, and allow HCV... Agent: Common Services Agency

20110287407 - Integrated methods and systems for processing a molecular profile: An automated and integrated matching of a biological specimen to an individual, can include a collector having substrate materials and configured to selectively collect and release at least one bio-molecular species from a biological specimen; a self-contained mobile automated testing instrument configured to receive the biological specimen and further configured... Agent: Diomics Corporation

20110287406 - Novel hcv core+1 protein, methods for diagnosis of hcv infections, prophylaxis, and for screening of anti-hcv agents: The present invention relates to a novel form of core+1 protein of Hepatitis C virus (HCV), designated shorter form core+1 protein. The shorter form core+1 protein of Hepatitis C virus is the product of translation of a coding sequence consisting of all or part of a nucleotide sequence extending from... Agent: Institut Pasteur

20110287408 - Preparation of micro-porous crystals and conjugates thereof: A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The... Agent:

20110287412 - Methods for identifying rna segments bound by rna-binding proteins or ribonucleoprotein complexes: The present invention relates to a method for identifying a binding site on an RNA transcript, wherein the binding site binds to one or more binding moieties. The method includes, among other things, introducing a photoreactive nucleoside into living cells wherein the living cells incorporate the photoreactive nucleoside into RNA... Agent: Rockefeller University

20110287411 - Methods of chromosome drying and spreading: The present invention provides for a method of drying and spreading chromosomes from various biological samples to yield optimal chromosomal spreading. The method requires preparing a biological sample for treatment, providing a cytogenetic chamber capable of setting predetermined conditions, pre-testing a portion of the biological sample in the cytogenetic chamber,... Agent:

20110287413 - Microfluidic system: A microfluidic system comprising a 1st reaction zone, a 2nd reaction zone, a reagent delivery channel configured to deliver one or more reagents to the 1st reaction zone, a waste channel to remove waste from the 2nd reaction zone, a 1st sample delivery channel configured to deliver a sample to... Agent: Iti Scotland Limited

20110287427 - 3'oh-unblocked, nucleotides and nucleosides base modified with labels and photocleavable, terminating groups and methods for their use in dna sequencing: Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the nucleobase to include a fluorescent dye attached via a linker... Agent: Lasergen, Inc.

20110287426 - Apparatus and methods for analyzing samples: The present invention relates to apparatus, systems, and methods for analyzing biological samples. The apparatus, systems, and methods can involve using a vacuum source to pull microfluidic volumes through analytical equipment, such as flow cells and the like. Additionally, the invention involves using optical equipment in conjunction with the analytical... Agent: Helicos Biosciences Corporation

20110287425 - Assays to detect small-scale mutations in individual cells: Methods, compositions, and assays are described which are useful in identifying point mutations, identifying cancer cells, and diagnosing cancer.... Agent: Colorado State University Research Foundation

20110287418 - Compositions and methods for diagnosis and treatment of epilepsy: Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1, EFHC1 agonists, or EFHC1 analogs are provided. Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1a, EFHC1a agonists, or EFHC1a analogs are provided.... Agent:

20110287420 - Compositions for diagnosis and therapy of diseases associated with aberrant expression of kremen and/or wnt: The present invention relates to a composition useful for the diagnosis and therapy of diseases associated with aberrant expression of the gene encoding the receptor Kremen 1 and/or Kremen 2 e.g. tumors or diseases of the kidneys, bones and eyes, lipid and glucose metabolism and obesity. The present invention also... Agent: Deutsches Krebsforschungszentrum Stiftung Des &#xd6 Ffentlichen Rechts

20110287423 - Diagnosis of viral infections by detection of genomic and infectious viral dna by molecular combing: A method for detecting in vitro the presence of a genome of a DNA virus or a viral derived DNA in an infected eukaryotic cell, tissue or biological fluid using Molecular Combing or other nucleic acid stretching methods together with probes, especially nucleic acid probes, having a special design. A... Agent: Genomic Vision

20110287415 - In-situ hybridization to detect rna and dna markers: The present invention provides probes, kits and methods for specifically binding mRNA of target cells, e.g., fetal cells, that allows visualization of the target cells, under conditions that allows a second probe to specifically bind the target cell's chromosomal DNA.... Agent: Novartis Ag

20110287419 - Method for genetic analysis of dna to detect sequence variances: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.... Agent:

20110287416 - Methylation detection: A real-time method of detecting the presence and/or amount of a methylated or unmethylated gene of interest in a DNA-containing sample, comprises the steps of: (a) contacting the DNA-containing sample with a reagent which selectively modifies unmethylated cytosine residues in the DNA to produce detectable modified residues but which does... Agent: Oncomethylome Sciences Sa

20110287424 - Methylation-specific competitive allele-specific taqman polymerase chain reaction (cast-pcr): In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating between different methylated and/or unmethylated nucleic acid loci. In certain embodiments, the inventions provides for detecting or quantitating undifferentiated embryonic stem cells in a population of differentiated cells. The invention is also useful... Agent: Life Technologies Corporation

20110287428 - Neisseria gonorrhoeae detection: A method for determining whether a human individual is or has been infected with Neisseria gonorrhoeae, is provided. The method detects a Neisseria gonorrhoeae, porA nucleic acid fragment obtained from a biological sample. The method includes subjecting the biological sample to nucleic acid sequence amplification using primers having respective nucleotide... Agent: The State Of Queensland Acting Through Its Department Of Health

20110287422 - Nucleic acid probes and methods for detecting plasmodium parasites: This invention relates to novel nucleic acid probes and methods for detecting Plasmodium parasites as well as detecting different Plasmodium parasites selectively from one another.... Agent: Id-fish Technology, Inc.

20110287417 - Predicting a response to risperidone: The invention relates generally to the relative effect of specific genetic polymorphisms in predicting the clinical outcome of risperidone therapy in patients suffering from a psychiatric disease such as schizophrenia.... Agent:

20110287421 - Probes for detection of nat2 gene, reagent containing the same, and the uses thereof: Primer sets for amplifying target regions containing sites to be detected in the NAT2 gene by a gene amplification method are provided, wherein the primer sets can amplify the regions specifically. Three pairs of primer sets are used including forward primers consisting of the base sequences of SEQ ID NOs:... Agent:

20110287414 - Systems and methods for identifying a portion of a molecule: Techniques for identifying a portion of a molecule are described herein. In one example, multiple electrical measurements associated with a molecule are acquired, wherein each of the multiple electrical measurements corresponds to a discrete position of the molecule within a nanopore. The multiple electrical measurements are correlated with one or... Agent: Genia Technologies, Inc.

20110287436 - Detection of analytes and nucleic acids: Methods of detecting at least one analyte and at least one nucleic acid in a sample are provided. Reagents for carrying out the methods are also provided.... Agent: Applied Biosystems, LLC

20110287433 - Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock: The present invention provides methods and kits to obtain an early evaluation of mortality risk and help therapeutic decisions for patients in severe sepsis with two organ failures, for example for patients in septic shock. The invention is based on the measure of the level of S100A8/A9 complex in plasma,... Agent:

20110287431 - Modified oligonucleotides and applications thereof: Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof.... Agent: Life Technologies Corporation

20110287430 - Non-thiopurine methyltransferase related effects in 6-mercaptopurine therapy: The present invention provides methods for predicting tolerance associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. In particular, the present invention provides methods for predicting a patient's risk of an adverse drug reaction (or tolerance) to a 6-mercaptopurine drug by genotyping a patient... Agent: Guy's And St. Thomas' Nhs Foundation Trust

20110287434 - Pregnancy testing: A method of determining the stage (gestation) of a pregnancy—comprising the steps of quantifying the amount of the hormone hPL or a fragment thereof in a body fluid sample derived from a human female selected from a blood, plasma, serum and/or urine sample, and establishing the stage of pregnancy corresponding... Agent: Guy's And St. Thomas Nhs Foundation Trust

20110287432 - System and method for tailoring nucleotide concentration to enzymatic efficiencies in dna sequencing technologies: An embodiment of a method for optimizing sequencing performance is described that comprises the steps of calculating a nucleotide species specific degradation rate of an apyrase enzyme for a plurality of nucleotide species; determining a concentration for each of the nucleotide species using the nucleotide species specific degradation rate; iteratively... Agent: 454 Life Science Corporation

20110287435 - Transposon end compositions and methods for modifying nucleic acids: Compositions of transposome complexes for generating DNA fragments with specific 5′- and 3′-tags. Kits for generating libraries for sequencing, with transposome complexes, enzymes, oligonucleotides or other components.... Agent: Epicentre Technologies Corporation

20110287429 - Use of haploid genomes for genetic diagnosis, modification and multiplication: Methods for propagating haploid genomes of male or female origina and genetic screening and modification thereof are provided. These haploid genomes may be used to produce haploid embryos, and embryonic stem-like cells and differentiated cells. Also, these haploid genomes and cells containing, may be used as nuclear transfer donors to... Agent:

20110287437 - Assays to predict cardiotoxicity: The likelihood that a compound will exhibit cardiotoxicity in vivo can be predicted using a model of in vitro assays performed on primary human cardiomyocytes.... Agent:

20110287439 - Clastogenicity testing: The present invention relates to improved methods for detecting agents that cause or potentiate DNA damage and to genetically transformed cells that may be usefully employed in such methods.... Agent: Remynd Nv

20110287438 - Sensor chip for screening topoisomerase inhibitor and screening method thereof: The present invention discloses a sensor chip for screening a topoisomerase inhibitor and a screening method thereof. The sensor chip comprises topoisomerase I and a biochip. The topoisomerase I is immobilized on the biochip, and the topoisomerase I has DNA catalytic activity. This provides a rapid screening method for topoisomerase... Agent: Taipei Medical University

20110287440 - Composition and method for reconstituting ikb kinase in yeast and method of using same: The invention provides a means for reconstituting IκB kinase in yeast in order to study the structure and regulation of IKK and to produce pharmacological therapies to block IKK. This invention can be used to express an IKK complex that is biochemically identical to IKK isolated from native cells and... Agent: University Of Southern California

20110287441 - Methods and materials for assessing enzyme-nucleic acid complexes: This document relates to methods and materials involved in assessing samples for enzyme-nucleic acid complexes. For example, methods and materials for using antibodies to determine the presence, absence, or amount of enzyme-nucleic acid complexes (e.g., human topoisomerase I-DNA complexes) in a sample (e.g., a biological sample such as a tissue... Agent:

20110287447 - Apparatus for and method of automated processing of biological samples: Provided herein is a bioprocessing device, bioprocessing card, and fluidics cartridge for performing automated bioprocessing of a sample. The bioprocessing card may include a plurality of pipette tips; and at least one pump in fluid communication with the plurality of pipette tips. In some embodiments, the pumps and the pipette... Agent: Life Technologies Corporation

20110287448 - Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor: The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding to the mid-portion or C terminus... Agent: Drg International, Inc.

20110287443 - High level expression of recombinant toxin proteins: The present invention relates to the field of recombinant toxin protein production in bacterial hosts. In particular, the present invention relates to production processes for obtaining high levels of a recombinant CRM197, Diphtheria Toxin, Pertussis Toxin, Tetanus Toxoid Fragment C, Cholera Toxin B, Cholera holotoxin, and Pseudomonas Exotoxin A, from... Agent: Pfenex Inc.

20110287446 - Immunoanalytical method and system using mass spectrometry technology: An immunoanalytical system in which, after a sample such as a patient's serum is subjected to a pretreatment by an immunological pretreatment device, the sample is subjected to light detection by an immunological photometric detection system. Subsequently, the mass spectrometric pretreatment device performs a pretreatment, and the mass spectrometric detection... Agent: Hitachi High-technologies Corporation

20110287444 - Immunoassay method for human cxcl1 protein:

20110287445 - Mutant ros expression in human cancer: The invention provides the identification of the presence of mutant ROS protein in human cancer. In some embodiments, the mutant ROS are FIG-ROS fusion proteins comprising part of the FIG protein fused to the kinase domain of the ROS kinase. In some embodiments, the mutant ROS is the overexpression of... Agent: Cell Signaling Technology, Inc.

20110287442 - Tumor antigen protein, gene, or peptides from topoisimerase 2 alpha: Provided is a tumor antigen protein, gene, or peptides derived from topoisomerase 2 alpha. As it is discovered that topoisomerase 2 alpha binds to an MHC class I or II antigen, thereby forming a complex, and the complex is recognized by cytotoxic T lymphocytes, the tumor antigen can be used... Agent: Catholic University Industry Academic Cooperation Foundation

20110287450 - Methods for diagnosing and monitoring the progression of cancer: Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided.... Agent: The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Service

20110287451 - Novel anti cxcr4 antibodies and their use for the treatment of cancer: t

20110287452 - Test kit for detecting klebsiella pneumoniae serotype k1 and method using same: Disclosed are a test kit and method for sensitively and rapidly detecting Klebsiella pneumoniae serotype K1. By using immunochromatographic test, the test kit can sensitively, rapidly and specifically identify whether specimens contain Klebsiella pneumoniae serotype K1. The sensitivity of the test kit preferably attains 1.4×105 cfu/50γ.... Agent: National Defense Medical Center

20110287449 - Myeloperoxidase, a risk indicator for cardiovascular disease: Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease. In one embodiment the present diagnostic test comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the individual or test subject. In another embodiment, the diagnostic test comprises determining the level... Agent: The Cleveland Clinic Foundation

20110287453 - Antibody binding specifically to tdp-43 aggregate: The present invention provides an antibody that specifically binds to an abnormal TDP-43 protein aggregate, an agent comprising the antibody for detecting a TDP-43 proteinopathy lesion, and a method for detecting or diagnosing a TDP-43 proteinopathy lesion by using the antibody.... Agent:

20110287457 - Compositions and methods for diagnosing and treating an inflammation: A method of reducing an inflammatory response in a subject is provided. The method comprising providing to a subject in need thereof a therapeutically effective amount of an agent capable of reducing activity and/or expression of a scavenger receptor or of an effector thereof, thereby reducing the inflammatory response in... Agent: Rappaport Family Institute For Research In The Medical Sciences

20110287454 - Methods for monoclonal antibody production: This invention provides improved methods for production of monoclonal antibodies against a protein of interest. The present methods are based on immunization of an animal with a fusion protein between a protein of interest and a Th2 cytokine such as IL-4, IL-5, IL-13 and IL-31.... Agent: Cornell University

20110287455 - Methods, devices and kits for detecting or monitoring acute kidney injury: Methods for detecting acute kidney injury in an individual comprise (a) contacting a body fluid sample from the individual with an assay device including neutrophil gelatinase-associated lipocalin (NGAL) antibody and a detectable label, to allow complexing of NGAL protein in the sample with NGAL antibody, and determining an amount of... Agent:

20110287456 - Synthetic peptides, methods and kits for diagnosing autoimmune diseases: Provided herein are synthetic peptides, methods and kits for easy detecting or diagnosing an autoimmune disease, particularly, Henoch-Schönlein purpura (HSP), based on the detection of autoimmune antibodies with peptides derived from β-2-glycoprotein-1 (β2-GPI).... Agent: Flysun Development Co. Ltd.

20110287458 - Method and composition for the diagnosis and monitoring of inflammatory diseases: The present invention provides a canine S100 calcium binding protein useful in diagnosing an inflammatory disease. Also provided are methods of diagnosing an inflammatory disease by assaying a biological sample for the canine S100 calcium binding protein. The invention further provides antibodies specifically binding to the canine S100 calcium binding... Agent: The Texas A&m University System

20110287459 - Luciferin luminescent substrate of marine ostracod crustacean and method for production thereof: e

20110287461 - Enzymatic analytical membrane, test device and method: The invention is directed to a novel enzymatic analytical membrane, a lateral flow enzymatic detection method, and analytical device incorporating same. The invention is useful for rapidly enzymatically determining the presence of one or more analytes in small volumes of sample. The invention provides an enzymatic analytical membrane for detecting... Agent: Zbx Corporation

20110287460 - Method of lipid assay and reagent for use therein: A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy... Agent: Daiichi Pure Chemicals Co., Ltd.

20110287462 - Protein fragment complementation assay for thermophiles: A protein fragment complementation assay for thermophiles is provided wherein a thermophilic bacteria having a temperature-sensitive adenylate kinase is transformed with one or more vectors having sequences encoding a first test peptide operatively fused to a first portion of a thermostable adenylate and a second test peptide operatively fused to... Agent: Rice University

20110287465 - Characterization of o-linked glycans: The present disclosure provides methods for analyzing structure and/or composition of glycoproteins and glycans of glycoproteins. Such methods can include subjecting a glycoprotein preparation to a condition that removes at least one O-linked glycan from the glycoprotein. Such methods can include subjecting a glycoprotein preparation to a condition that releases... Agent: Momenta Pharmaceuticals, Inc.

20110287464 - Chromogenic plating media for the identification of enterobacter sakazakii: A plating medium for identification of Enterobacter sakazakii bacteria having a carbohydrate, but Enterobacter sakazakii bacteria being incapable of fermenting any carbohydrate in the medium. The medium also contains a pH indicator dye that changes the color of the medium from a first color to a second color when the... Agent:

20110287463 - Recombinant beta-galactosidase derived from streptococcus pneumoniae: The present invention relates to a novel beta-galactosidase derived from Streptococcus pneumoniae, a BgaC protein exhibiting the enzyme activity, and a method for using the same. The protein can be used in the modification and analysis of sugar chain and used as an anti-cancer agent.... Agent: Korea Research Institute Of Bioscience And Biotechnology

20110287466 - Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates: A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate.... Agent: Mountain View Pharmaceuticals, Inc.,

20110287467 - Methods of producing recombinant heme-binding proteins and uses thereof: The present invention is directed to methods of producing recombinant functional heme-binding proteins with complete heme incorporation and purified preparations of the same. The present invention is further directed to methods of identifying agents that modulate the activity of heme-binding proteins.... Agent: Cornell University

20110287468 - Methods and compositions for assaying enzymatic activity of myeloperoxidase in blood samples: The present invention provides a two-step assay for measuring myeloperoxidase (MPO) activity in a blood sample. The first step utilizes a chromogenic substrate to measure first peroxidase activity including MPO activity in the sample, whereas the second step measures non-MPO peroxidase activity in the presence of the same chromogenic substrate... Agent: General Atomics

20110287470 - Cell culture method to form aggregates: The invention relates to the field of cell and tissue culture. In particular, the invention provides methods for culturing cells to form aggregates, including stem cells and primary cells. A method for culturing cells according to the invention comprises the steps of: (i) incubating a cells in a hanging drop... Agent:

20110287469 - Device for investigation of a flow conduit: A device for investigation of a flow conduit comprising: a base; and a module formed in the base, the module comprising: a main channel for the flow conduit, the main channel having a loading inlet for loading the flow conduit; a culture chamber in the main channel for at least... Agent: The Governing Council Of The University Of Toronto

20110287472 - Modular system of functional units for mixing, processing and/or separating samples for use in biological/medical research and for diagnostics: The system according to the invention comprises freely combinable functional units and consists of mixing cylinders, separating devices and a flow-regulating connection unit, preferably formed as a vacuum unit, which is designed such that they are connected, preferably via simple plug connections, in any desired sequence to as many functional... Agent: Universitat Leipzig

20110287473 - Novel fluorescent boron-substituted dipyrromethenes and use thereof for diagnosis: The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates to biological molecules marked with said fluorescent compounds, and to the use thereof in detection methods such... Agent:

20110287471 - System and method of producing volatile organic compounds from fungi: An isolated fungus is described. The isolated fungus produces at least one compound selected from the group consisting of 1,8-cineole, 1-methyl-1,4-cyclohexadiene, and (+)-α-methylene-α-fenchocamphorone. A method for producing at least one compound selected from the group consisting of 1,8-cineole, 1-methyl-1,4-cyclohexadiene, and (+)-α-methylene-α-fenchocamphorone is also described. The method includes culturing a fungus... Agent:

20110287474 - Cultures and protocols for diagnosis of toxigenic clostridium difficile: Disclosed are culture media, protocols and kits for diagnosis of toxigenic Clostridium difficile, where the culture medium comprises Cooked Meat Medium with glucose; yeast extract; taurocholate; cycloserine; and cefoxitin.... Agent:

20110287475 - Tissue fixative having increased viscosity: A gel fixative composition having increased, viscosity which fixes tissues as well as or better than standard liquid fixative solutions. The gel fixative compositions are less prone to leakage and are less likely to splash or spill from containers when they are mishandled. Because of their viscosity, they are less... Agent: Azer Scientific, Inc.

20110287476 - Production of isoprenoids: The present invention provides methods for a robust production of isoprenoids via one or more biosynthetic pathways. The invention also provides nucleic acids, enzymes, expression vectors, and genetically modified host cells for carrying out the subject methods. The invention also provides fermentation methods for high productivity of isoprenoids from genetically... Agent:

20110287479 - Protease catalyzed in situ end capping of oligopeptides in aqueous media: One-pot biotransformations give oligo(γ-L-Et-Glu) decorated with selected amine-functionalized end-groups at C-termini with a first process controlling the end group structure of peptides synthesized by protease catalyzed peptide synthesis, and a second process incorporating end-groups that can be used directly or after further modification as polymerizable entities. Papain, bromelain, α-chymotrypsin, Multifect... Agent: Polytechnic Institute Of New York University

20110287478 - Protein concentrates and isolates, and processes for the production thereof: Protein concentrates and protein isolates, in addition to processes for the production of protein concentrates and protein isolates, are disclosed. In particular, the disclosure relates to the removal of fiber from an oilseed meal using low g-force centrifugation.... Agent:

20110287477 - Protein concentrates and isolates, and processes for the production thereof from toasted oilseed meal: Protein concentrates and protein isolates, in addition to processes for the production of protein concentrates and protein isolates, are disclosed. In particular, the disclosure relates to the removal of fiber from a toasted oilseed meal using low g-force centrifugation.... Agent:

20110287481 - Host, transformant and method for producing the transformant and method for producing o-glycosylated heterologous protein: An Schizosaccharomyces pombe host having no omh1 gene or an inactivated omh1 gene in its chromosomes for producing an O-glycosylated heterologous protein having an O-linked sugar chain having an O-Man-Gal disaccharide structure by expression of the heterologous protein by a genetic engineering technique and subsequent glycosylation of the expressed heterologous... Agent: Asahi Glass Company, Limited

20110287482 - Medium for the protein-free and serum-free cultivation of cells: A medium is described for the protein-free and serum-free cultivation of cells, especially mammalian cells, whereby the medium contains a proportion of soy hydrolysate.... Agent: Baxter Innovations Gmbh

20110287480 - Neurogenin: The invention relates to novel neurogenin proteins, nucleic acids and antibodies.... Agent:

20110287483 - Production of glycoproteins using manganese: Culture media comprising manganese and methods of culturing cells to improve sialylation and glycosylation of glycoproteins are provided.... Agent:

20110287484 - Expression vector containing the major envelope protein p9 of cystovirus phi6 as a fusion partner, and process for producing a membrane protein using the same: The present invention relates to a membrane protein expression vector containing the major envelope protein P9 of Cystovirus phi6 as a fusion partner, to cells transformed by the expression vector, and to a process for producing membrane proteins using the cells. Target proteins can be effectively expressed by the expression... Agent: Foundation Of Soongsil University-industry Coopera

20110287486 - Method for in vitro molecular evolution of protein function: The present invention relates to a method for in vitro creation of molecular libraries evolution of protein function. Particularly, it relates to variability and modification of protein function by shuffling polynucleotide sequence segments. A protein of desired characteristics can be obtained by incorporating variant peptide regions (variant motifs) into defined... Agent:

20110287485 - Methods of generating libraries and uses thereof: This invention relates to methods for the generation of humanized antibodies, particularly a humanized antibody heavy chain protein and a humanized antibody light chain protein. The method comprises using cells that express or can be induced to express Activation Induced Cytidine Deaminase (AID).... Agent: Anaptysbio, Inc.

20110287487 - Hyaluronan synthase genes and expression thereof in bacillus hosts: The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronan synthase (HAS). The recombinant Bacillus host cell is utilized in a method for producing hyaluronic acid (HA).... Agent:

20110287488 - Novel n-acetylglucosamine-2-epimerase and method for producing cmp-neuraminic acid using the same: The present invention relates to a novel N-acetylglucosamine-2-epimerase and a method for preparing CMP-N-acetylneuraminic acid, more specifically, relates to a N-acetylglucosamine-2-epimerase derived from Bacteroides fragilis NCTC 9343, and a method for preparing CMP-N-acetylneuraminic acid using said N-acetylglucosamine-2-epimerase. According to the present invention, CMP-N-acetylneuraminic acid can be produced economically in a... Agent: Gene Chem Inc.

20110287489 - Recombinational cloning using engineered recombination sites: Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have the desired characteristic(s) and/or DNA segment(s).... Agent: Life Technologies Corporation

20110287491 - Complexity management of genomic dna: The presently claimed invention provides for novel methods and kits for reducing the complexity of a nucleic acid sample by providing non-gel based methods for amplification of a subset of the sequences in a sample. In a preferred embodiment, amplification of a subset can be accomplished by digesting a sample... Agent: Affymetrix, Inc.

20110287490 - Gene synthesis by convergent assembly of oligonucleotide subsets: The invention provides a system and method for synthesizing polynucleotides by solid phase assembly oligonucleotide precursors, in accordance with the method, a polynucleotide is partitioned into an ordered set of subunits, wherein each subunit is assembled in a single reaction from a subset of oligonucleotide precursors that uniquely anneal together... Agent:

20110287492 - Method for the reduction of repetitive sequences in adapter-ligated restriction fragments: The present invention relates to a method for the reduction of repetitive sequences (or the improvement in low-copy sequences) in DNA samples by a combination of restriction endonuclease treatment, followed by adapter ligation, renaturation kinetics-based fractionation, optionally coupled with duplex sequence nucleases and further restriction endonuclease treatment, followed by adapter... Agent: Keygene N.v.

20110287493 - Formic acid treatments of biomass feedstock: The instant invention pertains to the use of formic acid in new processes for treating feedstocks comprising holocellulose, as well as, new compositions suitable for, for example, bioalcohol production. The processes may comprise first mixing the feedstock with an aqueous acid solution comprising formic acid and then producing a hydrolysis... Agent: Georgia Tech Research Corporation

20110287494 - Process for production of optically active amine derivative: e

20110287497 - Anaerobic organisms in a process for converting biomass: A method for integrating biological conversion of mixed acids to hydrocarbons, hydrocarbon-like molecules, biofuels, and combinations thereof. The method including introducing fermentation products to at least one microorganism chosen from the group consisting of heterotrophic microorganisms, photo-mixotrophic microorganisms, chemo-autotrophic microorganisms, and combinations thereof.... Agent:

20110287496 - Hydrolases, nucleic acids encoding them and methods for biocatalytic synthesis of structured lipids: Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils,... Agent: Bunge Oils, Inc.

20110287495 - Hydrolases, nucleic acids encoding them and methods to produce triglycerides: Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils,... Agent:

20110287498 - Processing biomass: Carbon-containing materials, such as biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) or coal are processed to produce useful products, such as fuels, carboxylic acids and equivalents thereof (e.g., esters and salts). For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials... Agent: Xyleco, Inc.

20110287499 - Nucleic acid molecules conferring enhanced ethanol tolerance and microorganisms having enhanced tolerance to ethanol: The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol. The invention also provides related expression vectors, genetically engineered microorganisms having enhanced tolerance to ethanol, as well as methods of making and using such genetically modified... Agent: Ut- Battelle

20110287500 - Cytosolic isobutanol pathway localization for the production of isobutanol: The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects... Agent: Gevo, Inc.

20110287501 - Increased ethanol production in recombinant bacteria: The invention pertains to a recombinant bacterium with enhanced ethanol production characteristics when cultivated in a growth medium comprising glycerol. The recombinant bacterium comprises an inserted heterologous gene encoding glycerol dehydrogenase, and/or an up-regulated native gene encoding glycerol dehydrogenase. Particularly there is provided the recombinant bacterium BG1G1 of the Thermoanaerobacter... Agent: Biogasol Ipr Aps

20110287502 - Methods and apparatus for processing cellulosic biomass: Embodiments of the present invention are directed to apparatus and methods for the substantially continuous processing of cellulosic biomasses with a supercritical, critical or near critical fluid to produce ethanol, bio-fuels and high value end products.... Agent:

20110287504 - Method and system for converting electricity into alternative energy resources: A method of using electricity to produce methane includes maintaining a culture comprising living methanogenic microorganisms at a temperature above 50° C. in a reactor having a first chamber and a second chamber separated by a proton permeable barrier, the first chamber comprising a passage between an inlet and an... Agent: The University Of Chicago

20110287503 - Methods for producing hydrocarbon products from algal biomass: Methods for producing hydrocarbon oils from algal biomass are provided. The algal biomass is hydrogenolysed under reaction conditions sufficient to produce a partially deoxygenated lipid-based oil. The algal biomass may be whole algal biomass, residual algal biomass, or both. The algal biomass is hydrogenolysed by liquefying the algal biomass in... Agent: Uop LLC

20110287505 - Genetically modified yeast species, and fermentation processes using genetically modified yeast: Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.... Agent:

20110287506 - Genetically modified yeast species, and fermentation processes using genetically modified yeast: Yeastcells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.... Agent:

20110287507 - Process for growing biomass by modulating supply of gas to reaction zone: There is provided a process of growing a phototrophic biomass in a reaction zone. The reaction zone includes an operative reaction mixture. The operative reaction mixture includes the phototrophic biomass disposed in an aqueous medium. Gaseous exhaust material is produced with a gaseous exhaust material producing process, wherein the gaseous... Agent: Pond Biofuels Inc.

20110287508 - Bioreactors for tissue engineering: Bioreactors and methods of using them to produce tissue engineered products or culture cells are disclosed, and more particularly on the development of a tissue and cell culture method based upon an expanded bed bioreactor in which an initial resting bed of particles on which or in which cells are... Agent:

20110287509 - Stable biocatalysts of penicillin acylase as gel aggregates and the process of manufacture thereof: The present invention provides a stable and viable biocatalyst with high activity and operational stability and method of immobilization thereof. The immobilization process is based on the principle of entrapment of partially purified enzyme precipitate which is simultaneously aggregated by cross linking agent like glutaraldehyde and further entrapped in a... Agent: Fermenta Biotech Limited

20110287510 - Methods and kits for reducing non-specific nucleic acid amplification: Methods and kits for efficient amplification of nucleic acids are provided. The methods comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having terminal mismatch primer-dimer structure. The methods also comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having nucleotide analogues. The methods... Agent: General Electric Company

20110287511 - Novel trichoderma genes: Described herein are novel gene sequences isolated from Trichoderma reesei. Two genes encoding proteins comprising a cellulose binding domain, one encoding an arabionfuranosidase and one encoding an acetylxylanesterase are described. The sequences, CIP1 and CIP2, contain a cellulose binding domain. These proteins are especially useful in the textile and detergent... Agent: Danisco US Inc.

20110287512 - Compositions for linking zinc finger modules: Disclosed herein are compositions for linking DNA binding modules to allow for specific and selective binding to module subsites separated by 1 or more base pairs. Also described are methods of making and using compositions comprising these linkers.... Agent: Sangamo Biosciences, Inc.

20110287513 - Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof: A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide.... Agent:

20110287514 - Cytotoxic ribonuclease variants: This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the ribonuclease inhibitor while still retaining catalytic properties. While earlier work had identified some... Agent:

20110287515 - Protein and dna sequence encoding a cold adapted xylanase: A method of preparing a cold adapted xylanase by use of recombinant DNA techniques. A nucleic acid and corresponding amino acid sequences of a cold adapted xylanase, isolated from antarctic marine origin, preferably from an Antarctic bacteria (Psychrobacter sp.) are provided. These can be used in a variety of industrial... Agent: University Of Chile

20110287516 - Alpha-amylase variants: The invention relates to a variant of a parent Termamyl-like alpha-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of... Agent: Novozymes A/s

20110287517 - Degradable clostridial toxins: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.... Agent: Allergan, Inc.

20110287518 - Polypeptide purification: The invention relates to the purification of different gamma carboxylated forms of a polypeptide using ion exchange chromatography. In particular, the invention provides a method for purifying a polypeptide having a desired content of gamma-carboxyglutamic acid from a sample comprising mixture of species of said polypeptide having different contents of... Agent: Novo Nordisk Health Care A/g

20110287519 - High yield yellow fever virus strain with increased propagation in cells: The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also... Agent: Xcellerex, Inc.

20110287520 - Salmonella marker vaccine: The present invention relates to a Salmonella strain suitable as a marker vaccine having an inactivated gene.... Agent:

20110287521 - Biosynthesis of commodity chemicals: Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting suitable monosaccharides or oligosaccharides, such as those derived from biomass, as well as various aldehydes and/or ketones, into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum... Agent: Bio Architecture Lab, Inc.

20110287524 - Methods and systems for predictive design of structures based on organic models: A method and system to predict a design of an article of manufacture, which can include the steps of introducing a biological organism into a test environment to activate at least one molecular component of the biological organism representing at least one set of genetic characters of the biological organism;... Agent: Diomics Corporation

20110287522 - Producing biomass using pressurized exhaust gas: There is provided a process of growing a phototrophic biomass in a reaction zone. The reaction zone includes an operative reaction mixture. The operative reaction mixture includes the phototrophic biomass disposed in an aqueous medium. Gaseous exhaust material is produced with a gaseous exhaust material producing process, wherein the gaseous... Agent: Pond Biofuels Inc.

20110287523 - Recovering make-up water during biomass production: There is provided a process of growing a phototrophic biomass in a reaction zone. The reaction zone includes an operative reaction mixture. The operative reaction mixture includes the phototrophic biomass disposed in an aqueous medium. Gaseous exhaust material is produced with a gaseous exhaust material producing process, wherein the gaseous... Agent: Pond Biofuels Inc.

20110287525 - Diluting exhaust gas being supplied to bioreactor: There is provided a process of growing a phototrophic biomass in a reaction zone. The reaction zone includes an operative reaction mixture. The operative reaction mixture includes the phototrophic biomass disposed in an aqueous medium. Gaseous exhaust material is produced with a gaseous exhaust material producing process, wherein the gaseous... Agent: Pond Biofuels Inc.

20110287526 - Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply: There is provided a process of growing a phototrophic biomass in a reaction zone. The reaction zone includes an operative reaction mixture. The operative reaction mixture includes the phototrophic biomass disposed in an aqueous medium. Gaseous exhaust material is produced with a gaseous exhaust material producing process, wherein the gaseous... Agent: Pond Biofuels Inc.

20110287527 - Gas treatment appliance and gas treatment process: A gas treatment appliance and a gas treatment process are provided. The proportion of tar is decreased in a product gas formed on the gasification of carbonaceous feedstocks. The product gas or synthesis gas formed on the gasification of carbonaceous feedstocks is generally highly polluted with tar. This tar-polluted gas... Agent: Bekon Energy Technologies Gmbh & Co. Kg

20110287528 - Devices, systems, and methods related to analyte monitoring and management: Analyte monitoring devices, systems, and methods are provided that relate to: enabling different application features on a data processing device for analyte monitoring devices with different analyte monitoring features; programming analyte monitoring devices in advance; personalizing an analyte monitoring device; graphically representing a remaining insulin level in a user body;... Agent: Abbott Diabetes Care Inc.

20110287529 - Syringe-shaped culture tube and cell culture apparatus using same: The cell culture apparatus according to the present disclosure includes: the culture tube with a culture space formed therein, wherein a vent hole through which the culture medium flows in and out of the culture space is formed at one or both ends of the culture tube and the inner... Agent: Corestem Co., Ltd.

20110287530 - Apparatus to characterize blood and red blood cells via erythrocyte membrane fragility quantification: The present disclosure describes an apparatus for quantifying the quality degradation of individual stored red blood cell (RBC) units, thereby yielding information to improve decisions regarding their respective allocation, patient suitability, and use. The apparatus for quantifying the quality degradation of individual stored (RBC) units comprises: a hemolysis unit; an... Agent:

20110287531 - Microalgae growth pond design: A raceway pond for circulating microalgae in a fluid medium includes a plurality of interconnected channels. Each channel is straight and has a structured gradient, due to tilt or terracing, that moves the fluid medium along the raceway. In operation, the concentration of microalgae in the fluid medium is maintained... Agent:

20110287532 - Expression of factor ix in gene therapy vectors: Two mechanisms are provided for improving the expression of Factor IX in gene therapy vectors. The first is the use of a specific Factor IX polynucleotide coding sequence designed for optimal expression. The second is the use of transcriptional regulatory regions minimized in size so that they can be used... Agent: St. Jude Children's Research Hospital

20110287533 - Novel lowered affinity antibodies and uses therefor: The present invention provides novel, rationally designed lowered affinity antibodies for use in various in vivo and in vitro applications. The antibodies of the present invention have variable domains that have been designed to reduce or eliminate the antigen binding activity of the parental antibody without altering the overall 3... Agent: Ab Biosciences, Inc.

20110287534 - Automated filling of flexible cryogenic storage bags with therapeutic cells: An apparatus and processes for aseptically dispensing live mammalian cells into sterile, flexible bags in a non-sterile atmosphere. The method includes the steps of: providing the cells suspended in a liquid; providing a plurality of sterile flexible bags fluidly connected to a main line by a plurality of branch lines... Agent: Lonza Walkersville, Inc.

20110287535 - Histone deacetylase inhibitors: Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of... Agent: Errant Gene Therapeutics, LLC

20110287537 - Neuroprotective agents for the prevention and treatment of neurodegenerative diseases: s

20110287536 - Simplified method for partial genetic and epigenetic reprogramming of cells: A method of partial, rapid and direct genetic and epigenetic reprogramming of biological cells without returning to the embryonic state can partially reprogram a cell to be treated to specifically modify the biological age of said cell to be treated without causing functional de-differentiation of said cell to be treated,... Agent:

20110287540 - Method for controlling proliferation of cord blood hematopoietic stem cells and use thereof: The present invention provides a method for controlling the proliferation and differentiation of cord blood-derived hematopoietic stem cells with excellent safety when proliferating them by culturing. The hematopoietic stem cells are inoculated into a medium containing a sonicated liquid component of cord blood. The proliferation and differentiation of the cord... Agent: Jms Co., Ltd.

20110287538 - Method for production of reprogrammed cell using chromosomally unintegrated virus vector: An objective of the present invention is to provide vectors for conveniently and efficiently producing ES-like cells in which foreign genes are not integrated into the chromosome. The present inventors discovered methods for producing ES-like cells from somatic cells using chromosomally non-integrating viral vectors. Since no foreign gene is integrated... Agent:

20110287539 - Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods of using the cells: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a... Agent: Kathoiieke Universitiet Leuven

20110287541 - Accordion bioreactor: Disclosed herein are bioreactors including a first sheet and a second sheet (one or both of which is substantially transparent to light), wherein the second sheet is disposed adjacent to the first sheet, and the first and second sheets are sealed along a first longitudinal edge, a second longitudinal edge,... Agent: The Arizona Board Of Regents On Behalf Of The University Of Arizona

20110287542 - Cell culture methods and devices utilizing gas permeable materials: Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.... Agent:

20110287543 - Cell culture methods and devices utilizing gas permeable materials: Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.... Agent:

20110287544 - Photobioreactor systems positioned on bodies of water: Certain embodiments and aspects of the present invention relate to a photobioreactor including photobioreactor units through which a liquid medium stream and a gas stream flow. The photobioreactor units are floated on a body of water such as a pond or a lake. The liquid medium comprises at least one... Agent:

20110287545 - Targeted genomic modification with partially single-stranded donor molecules: Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.... Agent: Sangamo Biosciences, Inc.

20110287546 - Automated intracellular manipulation and transfection: A method and apparatus whereby prokaryotic, eukaryotic and/or mammalian cells may have genetic agents inserted or removed or transferred in an automated and semi-quantitative fashion. The functional unit of the invention is composed of two rectangular plates: a contact plate with circular holes and a carefully aligned base plate with... Agent:

20110287547 - Nucleic acid delivery compositions and methods: Complexes comprising a cationic polymer, a nucleic acid and a metal ion are provided. In some embodiments, a complex may be used as a means for delivering nucleic acid to a cell. In some embodiments, a complex may be used as part of a gene therapy. Methods of making a... Agent:

  
11/17/2011 > 109 patent applications in 70 patent subcategories. recently filed with US Patent Office

20110281255 - Biological process for converting organic by-products or wastes into renewable energy and usable products: Apparatus for the treatment of organic waste streams is disclosed, in which the organic waste stream is treated in order to reduce the average particle size prior to entry into a biological reactor. The use of a mechanical device to reduce this average particle size while simultaneously mixing the organic... Agent: Pmc Biotec Company

20110281254 - Method and apparatus for anaerobic digestion for crop stalk: In this disclosure, the hydraulic circulation and PLC control system are applied. The digester vessels are used also as biogas storage tank with simple structure. It is safe to operate with low cost. This disclosure also discloses automatic mechanical stirring and feedstock heating outside the digester vessel as well as... Agent: Shengli Oilfield Shengli Power Machinery Co., Ltd.

20110281257 - Method for producing beta-santalene: A method of producing β-santalene by contacting at least one polypeptide with farnesyl pyrophosphate (FPP). This method may be carried out in vitro or in vivo to produce β-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of... Agent: Firmenich Sa

20110281256 - Systems and methods of detecting and demonstrating hair damage via evaluation of protein fragments: Embodiments of a method for demonstrating type and/or source of hair damage comprises extracting protein fragments from a hair sample with an aqueous solution, testing the resulting protein fragments with the MALDI-MS test, and then either comparing the results between a damaged sample and an undamaged sample or comparing the... Agent:

20110281258 - Human immunodeficiency virus and uses thereof: The present invention relates to Human Immunodeficiency Virus-1 (HIV-1) Group P of the strain designated 06CMU14788 and fragments thereof, primers which are derived from HIV-1 Group P, immunogenic regions thereof, immunoassays and nucleic acid based assays for the detection of Human Immunodeficiency Virus (HIV) that employ said HIV-1 Group P... Agent: Abbott Laboratories

20110281259 - Method and apparatus for the simultaneous, automated decomposition of a plurality of biological samples: The invention relates to a method for decomposing a biological sample (9), said method having the following steps: the sample (9) is put into a container (6) which is composed of plastic, in particular, the container (6) is inserted into an adapter (2, 2a), the adapter with the closed container... Agent: Qiagen Gmbh

20110281260 - Ribonucleic acid binding motif protein 20 sequence variants: This document relates to methods and materials for using nucleic acid and amino acid sequence variants of ribonucleic acid binding motif protein 20 (RBM20). For example, methods and materials for using nucleic acid sequence variants and/or their corresponding amino acid variants of RBM20 that are associated with dilated cardiomyopathy to... Agent:

20110281261 - Vectors: The present invention relates to a transfer vector for inserting a gene into a genetic locus of a baculovirus sequence. The transfer vector comprises an expression cassette comprising a eukaryotic promoter operably linked to the gene and a bipartite selection cassette. The present invention also relates to methods of using... Agent:

20110281263 - Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers: The present invention provides compositions and methods for the detection of nucleic acid sequences associated with chromosomal aberrations. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic... Agent:

20110281262 - Detection of germs associated with periodontitis: The invention relates to a method for detecting and/or determining bacteria associated with periodontitis from a biological sample with at least one of the oligonucleotides SEQ ID No. 1 to SEQ ID No. 5 as well as a microfluidic device for detecting and/or determining at least one germ associated with... Agent:

20110281267 - Functionalized microfluidic device for immunofluorescence: It is described a microfluidic device, for use in the field of analytical fluorescence based assays and, in particular, in FISH assays.... Agent: Tethis S.p.a.

20110281266 - Identification of nucleic acids: This disclosure relates to methods for identifying target nucleic acids in a sample by detecting an amplified sequence corresponding to the target using a detectable probe and by monitoring its melting temperature (Tm).... Agent: Life Technologies Corporation

20110281264 - Method for diagnosing and predicting cerebellar ataxia: The present invention relates to an in vitro method for diagnosing and/or predicting hereditary cerebellar ataxia in a dog, and/or identifying a dog which is healthy carrier of hereditary cerebellar ataxia, comprising determining the presence or absence of an homozygous or heterozygous genetic variation in the arylsulfatase G gene sequence... Agent:

20110281265 - Primer set for amplifying ugt1a1 gene, reagent for amplifying ugt1a1 gene containing the same, and the uses thereof: Primer sets for amplifying target regions containing sites to be detected in the UGT1A1 gene by a gene amplification method are provided, wherein the primer sets can amplify the regions specifically Three pairs of primer sets are used including forward primers consisting of the base sequences of SEQ ID NOs:... Agent:

20110281268 - Circulating microrna as a marker for hepatocellular carcinoma: Provided herein are methods for the diagnosis, or management of liver diseases, e.g. hepatocellular carcinoma, using profiles of the miRNAs determined from cellular or acellular body fluids.... Agent: Quest Diagnostics Investments Incorporated

20110281274 - Cosmetic use of an active agent capable of stimulating tensin 1 expression: A cosmetic skincare process intended to prevent and/or treat at least one cutaneous sign of aging, includes the topical application to the skin of a composition containing at least one active agent capable of stimulating tensin 1 expression. The cosmetic use of an active agent capable of stimulating tensin 1... Agent: Chanel Parfums Beaute

20110281270 - Efficient detection of double mutants of the cebpa gene in acute myeloid leukemia: The invention is in the field of molecular diagnostics for cancer, in particular, for acute myeloid leukemia (AML). The invention provides methods for diagnosing AML patients with a favorable prognosis. We have found that not all AML patients carrying a CEBPA mutation may have a more favorable prognosis. We found... Agent: Erasmus University Medical Center Rotterdam

20110281269 - Isolation and characterization of a single mitochondrion: A method for identifying mitochondrial heteroplasmy within eukaryotic cells is provided. This method includes means for isolating and capturing a single mitochondrion from at least one eukaryotic cell, wherein the means for isolating and capturing a single mitochondrion further includes optical tweezers or a similar optical technology; means for analyzing... Agent: Gettysburg College

20110281273 - Method of making dna tag: Provided is a method of determining a DNA tag which is a base sequence to be introduced into a genomic DNA sequence of an organism and an introduction site of the DNA tag into the genomic DNA sequence. The method includes: a step (S1) of obtaining a protein coding sequence... Agent: Spiber Inc.

20110281276 - Nucleic acid-free thermostable enzymes and methods of production thereof: The present invention provides thermostable enzymes, such as DNA polymerases and restriction endonucleases, that are substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in amplifying or sequencing nucleic acid molecules, including... Agent: Life Technologies Corporation

20110281271 - Oligoribonucleotide or peptide nucleic acid capable of inhibiting activity of hepatitis c virus: The present inventors focused on siE sequences that have been thought to show RNAi activity against HCV viral RNAs, and mainly selected the D5-50 and D5-197 regions present within the IRES region, and carried on the analysis. As a result, the present inventors successfully identified siRNA sequences that exhibit a... Agent: Chugai Seiyaku Kabushiki Kaisha

20110281275 - Primers for nucleic acid amplification in detecting beta-actin and test method using these primers: It is intended to provide novel primers for nucleic acid amplification to be used in detecting mRNA of a housekeeping gene, more particularly, confirming the amplification of β-actin or GAPDH. More specifically speaking, primers containing oligonucleotides having nucleotide sequences represented by any of SEQ ID NOS: 2 and 4 to... Agent: Sysmex Corporation

20110281272 - Processing and analysis of viscous liquid biological samples: The present invention provides a lysis buffer comprising a chaotropic agent and a reducing agent suitable for liquefaction of a highly viscous liquid biological sample, such as sputum, a use of said lysis buffer for the processing of a highly viscous liquid biological sample, methods for processing or analyzing a... Agent:

20110281277 - Composition, kit, and method for diagnosing colorectal cancer or ovarian cancer: The present invention relates to a composition for diagnosing colorectal cancer or ovarian cancer, comprising gene markers for quickly and correctly diagnosing colorectal cancer or ovarian cancer, and more particularly, to a composition for diagnosing colorectal cancer or ovarian cancer, comprising an agent measuring mRNA or protein levels of two... Agent:

20110281278 - High throughput assay for discovering new inhibitors of the girk1/4 channel: In certain embodiments of the present disclosure, a method for determining an inhibitor of acetylcholine-activated potassium channel is described. The method includes incubating a cardiac cell in a solution comprising a test compound. The method further includes adding a muscarine (M2) receptor agonist to the cardiac cell in the solution... Agent: University Of South Carolina

20110281281 - Integration-free human induced pluripotent stem cells from blood: Provided herein are methods for generating human induced pluripotent stem cells free from genomic integration of exogenous transgenes by transfecting into nucleated blood cells one or more DNA expression vectors (e.g., plasmid vectors) that do not contain a mammalian origin of replication, and encode and permit expression of one or... Agent: Ipierian, Inc.

20110281282 - Subpopulations of spore-like cells and uses thereof: Subpopulations of spore-like cells expressing specific cell surface and gene expression markers are provided. In one embodiment, the cells express at least one cell surface or gene expression marker selected from the group consisting of Oct4, nanog, Zfp296, cripto, Gdf3, UtF1, Ecat1, Esg1, Sox2, Pax6, nestin, SCA-1, CD29, CD34, CD90,... Agent: Vbi Technologies, L.L.C.

20110281283 - Yeast cell wall components and detection thereof: The present invention relates to animal feed additives and detection thereof in feed products. Additionally, the present invention relates to yeast cell wall components, their methods of isolation, and compositions and methods for the immunological detection thereof.... Agent: Alltech, Inc.

20110281279 - Circulating epha2 receptor: Provided are compositions, methods, and kits relating to the detection of a circulating or soluble form of the EphA2 receptor tyrosine kinase.... Agent: Siemens Healthcare Diagnostics Inc.

20110281280 - Methods and compositions for monitoring and risk prediction in cardiorenal syndrome: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such... Agent: Alere San Diego, Inc.

20110281285 - Assay for detecting cathepsin k activty in bone, cartilage and/or soft tissue: There is provided a method for detecting cathepsin K activity in bone, cartilage and/or connective tissue, the method comprising providing a biological sample, contacting the sample with an antibody having binding specificity for a neoepitope comprising EAGKPG (SEQ ID NO: 9), and detecting an immunocomplex formed between the antibody and... Agent:

20110281284 - Novel liver cancer marker: According to the present invention, HDGF in the blood of patients with chronic liver disease is measured to diagnose whether the patients have liver cancer. A measurement kit for the diagnosis is also provided.... Agent: Hyogo College Of Medicine

20110281286 - Expression vector for establishing highly productive cell and the highly productive cell: The present invention provides an expression vector which is effective in an efficient establishment of transformed cells which express the aimed protein gene in a high level. An expression vector which has a cassette for expressing the drug selective marker gene containing mRNA destabilizing sequence, at least one element for... Agent: Toyo Boseki Kabushiki Kaisha

20110281287 - Size self-limiting compositions and test devices for measuring analytes in biological fluids: A test strip or electrochemical sensor for measuring the amount of an analyte in a biological fluid, e.g. the glucose content of whole blood, includes a size self-limiting reagent formulation employing an enzyme system for reaction with the analyte, the reactive system mixed into a water-soluble swellable polymer matrix containing... Agent: Bayer Healthcare LLC

20110281289 - Quantification of enzyme activity by mass spectrometry using immobilized substrates: The disclosure relates to methods of analyzing the enzymatic activity of enzymes in samples containing a plurality of enzymes, using mass spectrometry. Immobilized substrates are employed. Purified enzymes and enzymes from crude cell lysates can be analyzed using the disclosed methods.... Agent: Ludwig Institute For Cancer Research Ltd.

20110281288 - Reusable nanowire field effect transistor system for detecting biomolecular interactions: A reusable nanowire field effect transistor for detecting biomolecular interactions. The field effect transistor contains nanowire covalently linked to a docking molecule, which is capable of binding to an anchor molecule in a reversible manner, i.e., at an association constant of 105 to 109 M−1.... Agent: Academia Sinica

20110281290 - Sox-based kinase sensor: Peptidyl sensors comprise a metal-binding peptide and one or two kinase recognition sequences with a hydroxyamino acid that can be phosphorylated in the presence of a kinase.... Agent: Massachusetts Institute Of Technology

20110281292 - Compositions and methods for identifying antigens which elicit an immune response: This invention relates to an expression vector wherein said expression vector comprises a polynucleotide promoter sequence, a polynucleotide encoding a signal sequence, a polynucleotide encoding an antigen protein or peptide, a polynucleotide encoding a cell binding element, and a polynucleotide polyadenylation sequence all operatively linked. More particularly, it relates to... Agent:

20110281291 - Identification and/or characterization of a microbial agent using taxonomic hierarchical classification: A method for identification and/or characterization of a microbial agent present in a sample includes a step of analytical test data (e.g., obtaining intrinsic fluorescence values over a range of emission wavelengths) from the microbial agent. The analytical test data is transformed thereby minimizing strain to strain variations within an... Agent: Biomerieux, Inc.

20110281295 - Method and device for culturing algae: According to one aspect, the invention relates to a device for culturing algae with natural light, including an enclosure with a culturing medium and the algae to be cultured, and a substrate arranged to receive solar radiation in order to perform photoconversion of said solar radiation, the substrate including at... Agent: Photofuel Sas

20110281294 - Method and device for measuring adhesion forces: A measurement head for measuring the adhesion force between a surface and a particle attached to the surface, a force measurement system and a method for measuring the adhesion force between a surface and a particle attached to the surface are described.... Agent: Nanogalax Ltd Oy

20110281293 - Preparation and its use of derivatization reagent for detecting l-carnitine or d-carnitine: A preparation method and its use of derivatisation reagent for detecting L-carnitine or D-carnitine are provided. The present reagent is stable. It can be used for detecting L-carnitine or D-carnitine accurately and sensitively. That is to say, the reagent is applied to detecting the amount of synthesized or natural L-carnitine... Agent:

20110281296 - Biological indicator with integral package: A biological indicator for determining the effectiveness of a sterilization process is disclosed having a package and carrier integral therewith. The package includes a first sheet and a second sheet having a bottom portion, side portions and a top portion. The first and second sheets are joined together generally along... Agent: Mesa Laboratories, Inc.

20110281297 - Tissue processing device with ultrasonic measuring chamber: A device is operable to measure the size of tissue particles. The device includes a reservoir for receiving tissue particles and an ultrasonic transducer. The ultrasonic transducer is operable to emit ultrasonic energy toward tissue particles in the reservoir. Control circuitry is operable to process ultrasonic energy received from the... Agent:

20110281298 - Method and apparatus to extracted and reduce dissolved hemi-cellulosic solids in biomass following pre-hydrolysis: A method to wash and remove dissolved solids from biomass including: discharging a biomass slurry from a pretreatment vessel to a biomass slurry retention device; adding recovered wash liquid to dilute the biomass slurry in the retention device, wherein the recovered wash liquid is extracted from a drainer device upstream... Agent: Andritz Inc.

20110281299 - Recombinant pokeweed antiviral proteins, compositions and methods related thereto: The present invention provides novel, modified pokeweed antiviral proteins, nucleic acids that encode the proteins, conjugates that incorporate the proteins, and methods to make and use the proteins. The present invention also provides methods to administer the conjugates to animals, for the purpose of directing toxin to particular cells.... Agent: Cedus, Inc.

20110281300 - Preparation method of recombinant protein by use of a fusion expression partner: The present invention relates to a preparation method using a fusion expression partner. The method includes preparing a polynucleotide encoding a fusion expression partner selected from the group consisting of SlyD (FKBR-type peptidyl prolyl cis-trans isomerase), Crr (glucose-specific phosphotransferase (PTS) enzyme IIA component), RpoS (RNA polymerase sigma factor), PotD (Spermidine/putrescine-binding... Agent: Nutrex Technology Co., Ltd

20110281301 - The secretory capacity in host cells: The invention concerns the field of protein production and cell culture technology. It describes a method of producing a heterologous protein of interest in a cell comprising a. Increasing the expression or activity of a secretion enhancing gene, and b. Increasing the expression or activity of an anti-apoptotic gene, and... Agent: Boehringer Ingelheim Pharma Gmbh & Co. Kg

20110281302 - Compositions and methods of treating disease with fgfr fusion proteins: The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their... Agent: Five Prime Therapeutics, Inc.

20110281303 - Polypeptides having acetyl xylan esterase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having acetyl xylan esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20110281304 - Process for plasmid dna fermentation: Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity in a fermentor. These processes feature fed-batch fermentation strategies, combined with novel growth... Agent: Nature Technology Corp.

20110281305 - Modified type a dna polymerases: The present invention provides improved DNA polymerases, in particular, type A DNA polymerases, that may be better suited for applications in recombinant DNA technologies. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used... Agent: Kapabiosystems

20110281306 - Novel zinc finger nuclease and uses thereof: The present invention relates to methods and compositions useful for targeted cleavage and alteration of a genomic sequence, targeted cleavage followed by homologous recombination between an exogenous polynucleotide and a genomic sequence, or targeted cleavage followed by non-homologous end joining.... Agent: Toolgen Incorporation

20110281307 - Method for post-extracting low acyl gellan gum: The present invention relates to a post extraction process for preparing low acyl gellan, comprising the steps: deacylation treatment of gellan gum-containing fermentation broth, enzyme treatment, flocculation of low acyl gellan gum with divalent or polyvalent metal cations, clarification treatment of gellan gum solution, dehydration treatment of gellan gum solution,... Agent: Zhejiang Dsm Zhongken Biotechnology Co., Ltd.

20110281308 - Yellow pigments generation deficient sphingomonas strain and application thereof in gellan gum production: A yellow pigments generation deficient Sphingomonas strain (Sphingomonas sp. ZD001) and application thereof in preparing gellan gum by microbial fermentation are provided. The strain is preserved in China Center for Type Culture Collection (CCTCC) with the address of Wuhan University, Wuhan, 430072, China, the preservation date of the strain is... Agent: Zhejiang University

20110281310 - Materials and methods for the efficient production of acetate and other products: The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred... Agent: University Of Florida Research Foundation, Inc.

20110281309 - Novel amino acid dehydrogenase, and process for producing l-amino acid, 2-oxo acid or d-amino acid: The present invention relates to a novel amino acid dehydrogenase, DNA encoding the enzyme, and a transformant having the DNA introduced therein. The present invention also relates to a process for producing an L-amino acid, 2-oxo acid or D-amino acid, which includes allowing the amino acid dehydrogenase or a microorganism... Agent: Kaneka Corporation

20110281311 - Method for producing l-amino acid: A bacterium which belongs to the family Enterobacteriaceae, and has an ability to produce L-lysine, L-threonine, L-asparagine, L-aspartic acid, L-methionine, L-alanine, L-isoleucine, and/or L-homoserine. The bacterium has been modified so that expression of the gltP and/or gltS genes is/are increased when cultured in a medium, resulting in the accumulation of... Agent:

20110281312 - Hydrolases, nucleic acids encoding them and methods for making and using them for biocatalytic synthesis of a structured lipid: Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils,... Agent:

20110281313 - Improved production of acid and solvent in microorganisms: The invention relates to a method and means for the bioengineered fermentative production of solvents, in particular of butanol, acetone and ethanol, and of short-chained carboxylic acids such as acetic acid and butyric acid, in particular in host cells of the species Clostridium. The invention provides new methods and means... Agent: Sudzucker Aktiengesell Schaft Mannheim/ochsenfurt

20110281315 - Method for producing 2-butanol and recombinant microorganism having 2-butanol production capacity: This invention is intended to produce 2-butanol with excellent productivity via a fermentation process. Recombinant microorganisms into which the acetoacetyl-CoA synthase gene and a group of genes (i.e., genes involved in 2-propanol synthesis) encoding a set of enzymes synthesizing 2-propanol from acetoacetyl-CoA have been introduced are cultured, so that, in... Agent: Toyota Jidosha Kabushiki Kaisha

20110281314 - Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol: Embodiments herein generally relate to methods, compositions, systems and uses for enabling bio-production of or increasing bio-production of alcohol molecules by microorganisms. Certain embodiments relate to compositions and methods enabling or increasing the bio-production of 4-carbon alcohol molecules by bacteria. In some embodiments, compositions and methods relate to introducing isobutyryl-CoA... Agent:

20110281316 - Bacillus based delivery system and methods of use: Herein a Bacillus exosporium molecule delivery (BEMD) system that provides a means to deliver molecules of interest (MOIs) to an environment is disclosed. The system results in the display of MOIs on the exosporium surface of Bacillus family members such that they can be delivered to an environment in a... Agent: The Curators Of The University Of Missouri

20110281317 - Conversion of cellulosic materials into glucose for use in bioethanol production: A method for producing an aqueous sugar solution from cellulosic materials comprising the steps of heating ground cellulosic materials with perchloric acid; neutralizing the heated materials with an alkali to yield a salt precipitate; and filtering the salt precipitate off to obtain the aqueous sugar solution.... Agent: Universiti Malaya

20110281318 - Method and apparatus for treating an off-gas stream: The present invention provides a method and apparatus for treating a first off-gas stream in a gasification process to provide an ammonium-rich stream. The method comprises providing a first off-gas stream by separating a slurry bleed stream in a sour slurry stripper to provide the first off-gas stream and a... Agent:

20110281319 - Tissue processing device with ultrasonic tissue particle separator: A device is operable to separate tissue particles. The device comprises a reservoir and an ultrasonic transducer. The reservoir is configured to receive tissue particles in a fluid. The ultrasonic transducer is operable to emit ultrasonic energy toward tissue particles in the reservoir. Control circuitry is configured to drive the... Agent:

20110281320 - Device for analyzing nucleic acids and apparatus for analyzing nucleic acids: An object of the present invention is to regularly align microparticles, on each of which a nucleic acid synthetase or a DNA probe capable of capturing a nucleic acid sample fragment is immobilized, on a support so as to improve throughput of nucleic acid analysis. The present invention relates to... Agent:

20110281321 - Microbial remediation system and method: Methods and systems for effecting an environmental change by providing an effector composition that includes lignocellulosic particles with at least one absorbed microorganism species, wherein the lignocellulosic particles are preferably kenaf particles. The method steps include mixing at least one microorganism species with kenaf particles to form an effector composition... Agent:

20110281322 - Inhibitors of bruton's tyrosine kinase: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination... Agent: Pharmacyclics, Inc.

20110281323 - Novel fungal laccases and uses thereof: Novel laccases from Cerrena sp. WR1 and Lentinus sp. and uses thereof.... Agent: Academia Sinica

20110281324 - Enzymes with lipase activity: Described are detergent compositions comprising at least one lipase enzyme selected from SriII, ScoIIA, ScoIIB, CefII, and variants, thereof. The compositions are useful for removing oily stains from fabric.... Agent: Danisco US Inc.

20110281325 - Lipolytic enzyme lip1: The present invention provides a novel nucleic acid sequence, designated LIP1, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for... Agent: Danisco Us, Inc.

20110281326 - Pullulanase variants with increased productivity: The invention relates to novel variants of the enzymatic peptide pullulanase, the gene sequences encoding said novel peptides, expression vectors comprising those gene sequences as well as organisms expressing the novel pullulanase variants. The novel pullulanase variants of the present invention were made empirically by the use of codon-optimization procedures,... Agent: Danisco US Inc.

20110281327 - Compositions and methods comprising variant proteases: The present invention provides variant proteases, compositions comprising such variant proteases, and methods of cleaning comprising such variant proteases.... Agent: Danisco US Inc.

20110281328 - Compositions and methods comprising a subtilisin variant: The present invention provides a Bacillus sp. subtilisin variant. In addition, the present invention provides compositions comprising this serine protease variant. In some embodiments, the present invention provides laundry and other non-automatic (i.e., hand) dishwashing cleaning compositions comprising this serine protease variant.... Agent: Danisco US Inc.

20110281329 - Process and system for the industrial scale purification of bacteriophages intended for bacteriophage therapy: The present invention is directed towards bacteriophage therapy, the treatment of infectious diseases, caused by pathogenic bacteria, using specific bacteriophages. The purity of bacteriophage preparations has been a major obstacle for their therapeutic use in the past. Current purification methods are only suitable for low-scale production, as they are work... Agent: Gima S.p.a.

20110281331 - Arid land soil crust restoration: The present invention relates to a process for restoring disturbed arid land soil crust. According to the process, site-sourced biological soil crusts (BSC) serve as sources for liquid suspension inoculants onto degraded arid lands. The BSC are gathered from near the disturbed site, and organisms from them are cultured, replicated... Agent:

20110281333 - Methane production from single-cell organisms: The present invention relates to a method for enhancing the growth of single-cell organisms, such as methanogens. The growth of the single cell organisms includes consuming carbon dioxide to produce methane. The method can include providing a porous solid having an internal surface with a surface charge density, adhering the... Agent:

20110281330 - Minicells expressing antibodies or derivatives thereof and comprising biologically active compounds: Minicells are used to deliver biologically active compounds including radioisotopes, polypeptides, nucleic acids, small molecules, drug molecules, and chemotherapeutic agents. In some cases, the minicell displays ligands or binding moieties that target the minicell to a desired host cell.... Agent: Vaxiion Therapeutics, Inc.

20110281332 - Ochrobactrum sp. for degrading tetrabromobisphenol-a (tbbpa) and its application: The invention discloses an Ochrobactrum sp. for degrading TBBPA and its application in environmental remediation. An Ochrobactrum sp. for degrading TBBPA was isolated from the sludge in a high risk area of electronic waste in the invention. The strain is named as Ochrobactrum sp. T, which has been deposited in... Agent: Guangzhou Institute Of Geochemistry, Chinese Academy Of Sciences

20110281335 - Ethanol production in microorganisms: The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium.... Agent: Joule Unlimited, Inc.

20110281334 - Targeted gene deletions for polysaccharide slime formers: The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene M or gene N Sphingomonas strains containing at least one genetic modification that favors slime-forming polysaccaride production. Methods of making the mutant Sphingomonas strains and the culture broth containing such mutant Sphingomonas strains are also provided.... Agent: C.p. Kelco U.s., Inc.

20110281337 - Microorganisms for the production of 1,4-butanediol: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.... Agent:

20110281336 - Methods of sustaining culture viability: The present invention relates to methods for sustaining a microbial culture during periods of limited substrate supply. In accordance with the methods of the invention a microbial culture comprising carboxydotrophic bacteria can be sustained during periods of limited substrate supply by maintaining the temperature of the microbial culture at a... Agent: Lanzatech New Zealand Limited

20110281338 - Nitrate-removing bioreactor, method for forming nitrate-removing biofilm, and nitrate-removing method: Disclosed is a bioreactor which is capable of efficiently removing nitrate ions. A nitrate-removing bioreactor (1) comprises a reaction container (2) and an introduction part (3) for introducing a fermentation source (S) into the reaction container (2), said introduction part (3) being provided onto the upper part of the reaction... Agent:

20110281339 - System and method to create a traveling wave within a photobiotic reactor to enhance algae growth: A photobioreactor with a gas input is disclosed herein. The photobioreactor is tilted about an axis of rotation at various angles to provide for various flow patterns of bubbles created by the gas input. The flow patterns may vary, but include: bubble flow; slug or plug flow; churn; annular flow;... Agent: Photon8, Inc.

20110281340 - Systems and methods for positioning flexible floating photobioreactors: A top reference photobioreactor system according to an embodiment of the present invention includes a flexible floating photobioreactor having a buoyancy tube filled with a gas that is less dense, and a ballast tube filled with a substance, such as saltwater, that is more dense, than the liquid in which... Agent:

20110281341 - Biological process for converting organic by-products or wastes into renewable energy and usable products: Apparatus for the treatment of organic waste streams is disclosed, in which the organic waste stream is treated in order to reduce the average particle size prior to entry into a biological reactor. The use of a mechanical device to reduce this average particle size while simultaneously mixing the organic... Agent: Pmc Biotec Company

20110281343 - Bioreactor with rods arrayed for culturing anchorage-dependent cells: The instant invention employs an array of rods packed into a suitable chamber to support the culture, e.g., maintenance and/or growth of anchorage-dependent cells that effectively increases the surface area available for cell culture. Adherent cells are seeded and propagated on the surface of the rods. Each rod is accommodated... Agent:

20110281344 - Detection device: A detection device and a detection method are disclosed. The detection device comprises a sample inlet (132) that allows liquid samples flowing from a collection chamber (20) to a detection chamber (10), which comprises a through hole (135) that allows gases circulation between the detection chamber and the collection chamber,... Agent: Alere Switzerland Gmbh

20110281342 - Hand-held device for measuring an analyte concentration in a sample of a body liquid: A hand-held device for measuring an analyte concentration in a sample of a body liquid includes a display means for displaying measured values; a measured-value storage for storing measured values; a measuring unit for generating measured values through measurements of the analyte concentration; a clock; a control unit for generating... Agent:

20110281345 - Continuous flow worm farm: An apparatus for the treatment of organic matter with worms, includes a receptacle with a side wall at least a portion of which is downwardly tapering to facilitate compression of organic matter as organic matter is processed, an upper entry aperture for loading the receptacle with the organic matter and... Agent: Low Impact Limited

20110281346 - Donated blood collection kit: A donated blood collection kit includes an easy-to-open closed container. Stored within the container are items necessary or useful for collecting donated blood, such as an antiseptic scrub, an antiseptic swab, test tubes, a blood collection container, a gauze pad and a sheet of pre-printed adhesive barcode labels. Each kit... Agent: Haemonetics Corporation

20110281347 - Multivalent vaccines comprising recombinant viral vectors: Described are vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding at least two antigens from one or more tuberculosis-causing bacilli. Also described is the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage,... Agent: Crucell Holland B.v.

20110281348 - Agonist anti-trkc antibodies and methods using same: The invention concerns agonist anti-trkC antibodies, polypeptides, and polynucleotides encoding the same. The invention further concerns use of such antibodies, polypeptides and/or polynucleotides in the treatment and/or prevention of neuropathies, such as sensory neuropathies, including taxol-induced sensory neuropathy, cisplatin-induced sensory neuropathy, and pyridoxine-induced sensory neuropathy.... Agent: Rinat Neuroscience Corp.

20110281349 - Insect desiccation resistance genes and uses thereof: An objective of the present invention is to provide polynucleotides encoding insect desiccation resistance proteins, and uses thereof cDNA libraries were produced from Polypedilum vanderplanki larvae in a desiccated state, a P. vanderplanki EST database was constructed, and genes encoding LEA proteins were isolated. This resulted in the successful isolation... Agent: National Institute Of Agrobiological Sciences

20110281350 - Tissue processing system and method: A tissue processing system includes a tray and a processing component. The processing component has teeth configured to dice, mince, and mix the tissue in the tray. In some versions, teeth of a rotary member mesh with teeth of a stationary member, such that the tissue is ground between the... Agent:

20110281351 - Process for producing laminated high-density cultured artificial tissue, and laminated high-density cultured artificial tissue: Disclosed is a process for producing an artificial tissue, which comprises a step of providing a liquid flow control member and a mesh member in a flow path through which a cell culture liquid comprising at least one type of animal cells, a collagen-binding cell growth factor and an extracellular... Agent: School Juridical Person The Kitasato Institute

20110281352 - Transplant storage: A kit (1) for storing cells or tissues. The kit (1) comprises a frame (7) having an opening therein and a peripheral wall surrounding the opening. Also provided is a sealable receptacle (2) for receiving the frame (7) and for receiving a liquid medium (6). A section of the sealable... Agent: Medinnova As

20110281354 - Bispecific intracellular delivery vehicles: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of... Agent: University Of Washington

20110281353 - Composition and method for facilitating the internalization of a therapeutic agent into a cell: The present invention is a composition and method for facilitating the internalization of a therapeutic agent into a cell. Specifically, the invention relates to the use of the extracellular domain of basigin-2, cyclophilin, or anti-basigin-2 antibody or antibody fragment as a delivery moiety for internalization of a therape.... Agent: The Board Of Trustees Of The University Of Illinois

20110281356 - Compounds for stem cell differentiation: e

20110281355 - Differentiation of human embryonic stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells expressing markers characteristic of the pancreatic endoderm lineage, wherein greater than 50% of the cells in the population co-express... Agent: Centocor Ortho Biotech Inc.

20110281357 - Methods to cause differentiation of t-cells for use in cell therapy: A method resulting in differentiation of T-cells for use in cell therapy includes labeling the T-cells with a first array of antibodies specific for T-cell surface antigens; applying a universal cross-linking agent to the labeled T-cells with the first array of antibodies; labeling the T-cells with a second array of... Agent: Immunovative Therapies Ltd.

20110281358 - System for seeding cells onto three dimensional scaffolds: Systems are provided for convenient and sterile isolation, collection, and seeding of cells onto a scaffold or tissue graft. The systems may be closed. Methods for use of the disclosed systems for isolation, collection and seeding of cells and generation of tissue engineered vascular grafts are also provided. The systems... Agent: Yale University

20110281359 - Spnk strains: This invention includes spinosyn biosynthetic genes, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms. Additionally, the present invention includes methods and compositions... Agent: Dow Agrosciences LLC

20110281360 - Multi-chain eukaryotic display vectors and uses thereof: A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of the multi-chain polypeptide is exhibited at the surface of the host cell. Such a vector allows for the display of complex biologically active polypeptides, e.g.,... Agent: Dyax Corp.

20110281361 - Linear donor constructs for targeted integration: Disclosed herein are linear donor molecules comprising homology arms of 50-750 base pairs (e.g., 50-100 base pairs) flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for integration of an exogenous sequence into a specified region of interest in... Agent: Sangamo Biosciences, Inc.

20110281362 - Electrotransformation of gram-positive, anaerobic, thermophilic bacteria: The present invention relates to methods for transforming Gram-positive, anaerobic, thermophilic bacteria via electroporation and Gram-positive, anaerobic, thermophilic bacteria transformed by the disclosed methods. The methods employ voltage pulsing schemes that decrease arcing such that increased transformation efficiency and cell viability is observed. The present invention is further directed to... Agent: Mascoma Corporation

  
11/10/2011 > 107 patent applications in 62 patent subcategories. recently filed with US Patent Office

20110275052 - Heterogeneous inseminate system: A heterogeneous inseminate including a first amount of sperm of a first animal and a second amount of sperm of a second animal of the same species, the first amount of sperm and the second amount of sperm sex-selected sperm of the same sex, useful in the in-vivo or in-vitro... Agent: Xy, LLC

20110275053 - Alcohol production process: The invention relates to the production of products such as alcohols and acids by microbial fermentation, particularly microbial fermentation of substrates comprising CO. It more particularly relates to methods and systems for improving efficiency of products by microbial fermentation. In particular embodiments, the invention provides a method of optimising production... Agent: Lanza Tech New Zealand Limited

20110275054 - Enhanced animal cell growth using ultrasound: A method of increasing the rate of growth of an animal cell or cell culture include the use of ultrasound at a frequency greater than about 1 MHz.... Agent: Intelligentnano Inc.

20110275056 - Method and apparatus for controlling a cell expansion apparatus: A method for controlling cell expansion comprising conducting a fluid containing cellular matter into a cellular growth area; providing oxygenated fluid to said cellular growth area to maintain conditions conducive for cell growth in said cellular growth area; monitoring inflow and outflow conditions; determining rates of change (first derivative) for... Agent: Caridianbct, Inc.

20110275055 - Thermal uniformity for thermal cycler instrumentation using dynamic control: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector... Agent: Life Technologies Corporation

20110275057 - Allosteric control of proteins by manipulating mechanical tension: A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of the polypeptide, and altering the... Agent: The Regents Of The University Of California

20110275060 - Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells: The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.... Agent: University Of Pittsburgh - Of The Commonwealth System Of Higher Education

20110275059 - Diagnostic transcript and splice patterns of hr-hpv in different cervical lesions: The present invention relates to a method for differentiating in a subject with HR-HPV between a severe form of HR-HPV infection and a mild form of HR-HPV infection. It further is concerned with a composition comprising a probe oligonucleotide mixture, a device, and a kit for use in conjunction with... Agent: Deutsches Krebsforschungszentrum

20110275058 - Self-contained biological assay apparatus, methods, and applications: A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to... Agent: Rheonix, Inc.

20110275067 - Analysis of chemically crosslinked cellular samples: A method of analyzing cellular samples that include a chemically crosslinked analyte is provided. The analysis typically involves the use of mass spectrometry.... Agent: 3m Innovative Properties Company

20110275061 - Assays using surface-enhanced raman spectroscopy (sers)-active particles: Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.... Agent:

20110275064 - Method for hematology analysis: A method whereby one or more fluorescent dyes are used to bind and stain nucleic acids in certain blood cells, such as, for example, white blood cells, nucleated red blood cells, and reticulocytes, and to induce fluorescent emissions upon excitation of photons from a given source of light, such as,... Agent: Abbott Laboratories

20110275066 - Method of dna analysis using micro/nanochannel: Methods are provided for tagging, characterizing and sorting double-stranded biomolecules while maintaining the integrity of the biomolecules.... Agent:

20110275065 - Methods and compositions for the diagnosis and treatment of thyroid cancer: Methods for detecting thyroid cancer or thyroid cancer status in a subject are described comprising measuring novel markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for thyroid cancer, and kits for carrying out the methods of the invention.... Agent: Paul Walfish

20110275062 - Systems and methods for integrating a single dna molecule into a molecular electronic device: The disclosed subject matter provides a techniques for precisely and/or functionally cutting carbon nanotubes, e.g., single walled carbon nanotubes (“SWNTs”) and integrating a single nucleic acid molecule (e.g., a DNA molecule) into a gap formed into the carbon nanotubes. In one aspect, a method of fabricating a molecular electronic device... Agent: The Trustees Of Columbia University In The City Of New York

20110275063 - Systems and methods of droplet-based selection: The present invention generally relates to fluidic droplets, and techniques for screening or sorting such fluidic droplets. In some embodiments, the fluidic droplets may contain cells (e.g., hybridoma cells) that can secrete various species, such as antibodies, for example. In one aspect, a plurality of fluidic droplets containing cells is... Agent: President And Fellows Of Harvard College

20110275076 - Bulked mutant analysis (bma): The current invention relates to a new strategy for identification, and optional isolation, of a nucleic acid sequence that is expressed in an organism and that is related to a particular phenotype (trait of a character) of said organism. With the method of the current invention it has become possible... Agent: Keygene N.v.

20110275072 - Egfr mutations: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated... Agent: Genentech, Inc.

20110275070 - Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders: Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI3), and an oligonucleotide form unusually stable hybrids with complementary target sequences, in which the tethered CDPI3 group resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to... Agent:

20110275068 - Method: (iv) calculating the copy number of the test marker by comparing the number of amplified products for the test marker with a reference marker and wherein method B) comprises the step of analysing at least part of the sequence of an amplification product from the first and/or second amplification reaction.... Agent: Medical Research Council

20110275074 - Method and apparatus for chromosome profiling: A method and apparatus for generating an Interphase chromosome profile. The method comprises obtaining a sample containing cells having chromosomes for profiling; obtaining species specific DNA probes, wherein the DNA probes are capable of marking at least one chromosome at substantially equidistant locations on said chromosome; hybridizing the sample with... Agent:

20110275073 - Method for detecting tumor-associated dna in blood or blood fractions: This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and... Agent: The Penn State Research Foundation

20110275069 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts ad their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation... Agent: Genenews Corporation

20110275071 - Methods and reagents for combined pcr amplification: An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease activity of a polymerase and the... Agent: Life Technologies Corporation

20110275077 - Oligonucleotide-coated affinity membranes and uses thereof: A method of analyzing tissue sections in a manner that provides information about the presence and expression levels of multiple biomarkers at each location within the tissue section. The method comprises the preparation of membranes having covalently bound oligonucleotides and the use of those membranes for evaluation of various markers... Agent:

20110275078 - Rna-containing microvesicles and methods thereof: Contemplated compositions and methods are directed to the use of microvesicles from an optionally recombinant donor cell to impart a desirable effect to a recipient cell. In certain preferred aspects, RNA of the microvesicles is employed to achieve the desirable effect. For example, microvesicles are used in vitro to increase... Agent:

20110275075 - Sox modulators in the treatment of alopecia: An in vitro method for screening candidate compounds for the preventive or curative treatment of alopecia is described. The method can include determining the capacity of a compound to modulate the expression or the activity of a SOX transcription factor. The use of modulators of the expression or the activity... Agent: Galderma Research & Development

20110275081 - Biomarker for diagnosis of canine cancer: The present invention is related to a biomarker for diagnosis of canine cancer, wherein the biomarker is KMO (kynureinie 3-monooxygenase) gene, and the canine cancers including CTVT (canine transmissible venereal tumor) and MGT (mammary gland tumor). The expression level of KMO gene in canine malignant tumor tissues is up-regulated as... Agent: National Taiwan University

20110275079 - Diagnostic biomarkers of diabetes: Methods are disclosed for the identification of gene sets that are differentially expressed in PBMCs of patients diagnosed with a pre-diabetic disease state and overt type II diabetes. 3 gene and 10 gene signatures are shown to accurately predict a diabetic disease state in a patient. The application also described... Agent:

20110275082 - Genes involved in estrogen metabolism: The invention concerns genes that have been identified as being involved in estrogen metabolism, and are useful as diagnostic, prognostic and/or predictive markers in cancer. In particular, the invention concerns genes the tumor expression levels of which are useful in the diagnosis of cancers associated with estrogen metabolism, and/or in... Agent:

20110275083 - Genes involved in estrogen metabolism: The invention concerns genes that have been identified as being involved in estrogen metabolism, and are useful as diagnostic, prognostic and/or predictive markers in cancer. In particular, the invention concerns genes the tumor expression levels of which are useful in the diagnosis of cancers associated with estrogen metabolism, and/or in... Agent:

20110275087 - Instruments and methods for mixing the contents of a detection chamber: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included... Agent: Gen-probe Incorporated

20110275085 - Method for detection of autoimmune diseases: The present invention relates to the field of diagnostics, especially to the detection of autoimmune diseases such as rheumatoid arthritis. Particularly, the invention provides a method for detecting the presence or absence of rheumatoid arthritis, or of a predisposition therefore or for monitoring rheumatoid arthritis in a subject using expression... Agent: Terveyden Ja Hyvinvoinnin Laitos

20110275084 - Methods of determining susceptibility of tumors to tyrosine kinase inhibitors: This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly FGFR2 variants, which are linked to drug resistance. The disclosure further provides methods of diagnosis and theranosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions.... Agent: The Translational Genomics Research Institute

20110275086 - Negative correlation between irp-2 and transferrin receptor expression as a diagnostic of alzheimer's disease: A method of diagnosing Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) is disclosed which was identified by the fact that an increased level of iron regulating protein-2 (IRP-2) was identified in Alzheimer's patients. Further, diseases of increased cellular metabolism such as cancer showed high levels of both IRP-2 and... Agent: Loma Linda University Medical Center

20110275080 - Proteoglycan splice variants as therapeutics and diagnostics for amyloid diseases: The identification of novel Syndecan-2 splice variants and their use in the diagnosis and therapeutic intervention of Alzheimer's disease and other amyloid diseases. In addition the use of new animal models expressing or devoid of syndecan-2 splice variants to effectively screen and identify potential therapeutic compounds for Alzheimer's disease.... Agent:

20110275088 - Use of eef1a as biomarker and a method of screening metap2 inhibitors: The invention relates to a method for screening compounds, which inhibit MetAP2 activity, by providing a cellular system or a sample thereof being capable of expressing MetAP2 and/or EEF1A, incubating at least a portion of the system with compounds to be screened, and detecting MetAP2 inhibition by determining EEF1A with... Agent: Merck Patent Gesellschaft Mit Beschrankter Haftung

20110275089 - Methods for predicting survival in metastatic melanoma patients: Cellular and genetic signatures and methods of using same for subcategorizing stage III melanoma tumors are described herein. The signatures and methods are particularly useful with regard to establishing more distinct criteria on which basis to differentiate stage IIIB and IIIC melanoma patients. Assessment of the cellular and genetic signatures... Agent:

20110275090 - Use of achromopeptidase for lysis at room temperature: A process for detecting the presence or absence of gram-positive bacteria in a biological sample. The biological sample can be obtained from any mammal and contains, at a minimum, cellular components. The sample is combined with an enzymatic lysing agent such as achromopeptidase, and lysed at room temperature. Ferric oxide... Agent: Becton, Dickinson And Company

20110275092 - Method for detecting biological markers by an atomic force microscope: A method for detecting biological markers involves preparing sample slices using a hard granular labeling material such as hard nano-gold granular material. The sample slices are fixed to sample patches. The sample is scanned using the atomic force microscope (AFM) in tapping mode to collect the height, amplitude and phase... Agent: Chinese Academy Of Inspection And Quarantine

20110275093 - Novel use of adenoviruses and nucleic acids that code for said viruses: The present invention is related to the use of a virus, preferably an adenovirus, for the manufacture of a medicament, whereby the virus is replication deficient in cells which do not have YB-1 in the nucleus, and the virus codes for an oncogene or oncogene product, in particular an oncogene... Agent:

20110275091 - Use of precursors of tachykinins and/or their fragments in medical diagnostic: The present invention relates to the use of protachykinin and/or fragments thereof that can be isolated from body fluids, tissues or other bioiological samples and therefore, serves as a marker peptide for medical diagnosis of diseases/disorders of the central nervous system, including Alzheimer's disease, Parkinson's disease, depression and/or conditions of... Agent: Sphingotec Gmbh

20110275096 - Detection of activation of endothelial cells as surrogate marker for angiogenesis: Methods, compositions and kits are provided for assessing angiogenesis through sensitive, direct detection of activation of endothelial cells at molecular levels. In general, activation of endothelial cells is detected by measuring the levels of cellular components and their protein complexes participating in a specific angiogenesis signaling pathway in endothelial cells.... Agent:

20110275097 - Drug selection for lung cancer therapy using antibody-based arrays: The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of... Agent: Prometheus Laboratories Inc.

20110275094 - Phosphorylated fms-related tyrosine kinase 3 biomarker assay: Provided herein are methods for detecting the presence of human pFLT3 in a sample. An exemplary assay provided herein is an ELISA method (e.g., sandwich ELISA). Also provided herein are methods for detecting FLT3 phosphorylation in a sample, diagnosing a patient having a FLT3-activating mutation, identifying a compound that activates... Agent:

20110275095 - Microarrays for allergen-specific ige: Biological samples are assayed for the presence of IgE antibodies specific to unknown allergens in the samples. Known allergens conjugated to biotin are attached as an array of spots on a streptavidin-linked membrane. A sample is incubated with the membrane containing attached known allergens. After washing away excess sample, the... Agent: Siemens Healthcare Diagnostics Inc.

20110275099 - Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor: The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding... Agent: Drg International, Inc.

20110275098 - Method for evaluating the immunogenicity of proteins: The invention relates to a method for evaluating the immunogenicity of proteins in humans or animals, comprising analysing the CD4+ T lymphocyte response specific to the protein to be tested in individuals of the (human or animal) species in which the immunogenicity of said cell is analysed.... Agent:

20110275100 - Serpin b 13 as a marker for squamous cell carcinoma of the lung: Disclosed is a method aiding in the assessment of squamous cell carcinoma (SCC). It involves the use of the protein serpin B13 as a marker of SCC. Furthermore, the disclosure relates to a method for assessing lung cancer in a tissue sample derived from a patient having non-small cell lung... Agent:

20110275101 - Method for using division arrested cells in screening assays: Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.... Agent: Life Technologies Corporation

20110275102 - Activation of mutated rac-pk: The invention concerns RAC-PK and fragments thereof, as well as activators and inhibitors of RAC-PK for use as medicaments, particularly in the treatment of diseases concerned with abnormalities in processes modulated by insulin, such as cellular proliferation, insulin deficiency and/or excess blood sugar levels. Moreover, the invention provides RAC-PK for... Agent: Novartis Ag

20110275103 - Emission ratiometric reporters of membrane pdk1 activation: Phosphoinositide-dependent kinase 1 (PDK1) activity reporters can be used in high throughput assays for drug screening.... Agent: The Johns Hopkins University

20110275104 - Device and method for detection of humidity-compromised urine test strips: The timing of the reaction of moisture-sensitive reagents for detecting the presence of analytes, e.g. leukocytes in urine samples, is used to detect when the reagents have been compromised by excess humidity. The ratio of light reflectance at wavelengths characteristic of the products of reaction between the reagents and the... Agent: Siemens Healthcare Diagnostics Inc.

20110275106 - Device for measuring activity of cultured cells, microchamber and method of measuring activity of cultured cells: A device for measuring activity of cultured cells includes a position detecting unit specifying a position of a cell to be measured, a microchamber controlling unit disposing in the culture container a microchamber which surrounds the cell and forms a measurement space, the measurement space being minute with respect to... Agent: The University Of Tokyo

20110275109 - Immunity evaluation method, apparatus and program: An immunity evaluation method, apparatus, and program are provided that can evaluate comprehensive immunity with high precision. An immunity evaluation method for evaluating immunity from collected blood includes measuring a number of specific T cells that are CD8 positive and CD28 positive or negative in the collected blood, and determining... Agent: National University Corporation Tokyo Medical And Dental University

20110275107 - Long wavelength engineered fluorescent proteins: Engineered fluorescent proteins, nucleic acids encoding them and methods of use.... Agent: The State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of

20110275110 - Method for isolating or counting microorganisms on an agar culture medium: g

20110275108 - Method for releasing reducing glycan by ammonium salt: An objective of the present invention is to provide a glycan releasing method which can be applied to construction of a system for automation of glycan analysis, and particularly a glycan releasing method capable of analyzing an O-linked glycan. The objective could be achieved as a result of finding that... Agent: National University Corporation Hokkaido Universit

20110275105 - Methods of inducing pluripotency: Methods are provided for inducing non-pluripotent cells to become pluripotent. Methods also include identifying and isolating induced pluripotent (iPS) cells and uses thereof. Compositions and kits for carrying out the subject methods are also provided.... Agent:

20110275111 - Microfluidic device for full blood count: The present invention provides a microfluidic device (10) for full blood count. The microfluidic device (10) comprises a first measurement channel (11) and a second measurement channel (12) separated from the first measurement channel (11). The microfluidic device (10) furthermore comprises a first inlet (13) for providing a whole blood... Agent: Koninklijke Philips Electronics N.v.

20110275113 - Mass spectrophotometric detection of microbes: A method of detecting specified target microbes in different types of sample uses only one to two cultivation steps for the enrichment of the target microbes from the sample, preferably in selective culture media, combined with a mass spectrometric detection method that identifies the target microbes in mixtures with other... Agent:

20110275112 - Microbial growth detector: The disclosure generally relates to a test device that detects microorganism growth by detecting a gas metabolite (e.g., carbon dioxide) produced during the growth of bacteria or other microorganism in a tested sample. The test device can contain a culture growth media separated from a detection area by a gas-permeable... Agent: Neogen Corporation

20110275114 - Method and medium for detecting the presence or absence of methicillin resistant staphylococcus aureus (mrsa) in a test sample: A dry sample analyzing mixture, a liquid sample analyzing medium, and a sample analyzing method, are described for use in detecting the presence or absence of Methicillin Resistant Staphylococcus Aureus (“MRSA”) in an incubated first generation biological or environmental specimen sample. First generation specimen samples that can be analyzed include... Agent:

20110275115 - Method to detect endothelial cell massive calcium accumulation death: Stains that are specific for calcium ion are used to assess and predict the effects of various treatments on the viability of cell types contained in a sample, wherein said stain detects endothelial cells that have massive calcium accumulation death.... Agent:

20110275116 - Methods for control of flux in metabolic pathways through enzyme relocation: Genetically manipulated cells, lysates of such cells, systems, and methods of use thereof are provided, where one or more enzymes in a pathway of interest are genetically modified to incorporate a peptide sequence that provides for relocation of the protein, e.g., to the periplasm, so as to sequester the enzyme,... Agent:

20110275117 - Photobioreactor system with high specific growth rate and low dilution rate: Systems and methods for growing photosynthetic cells that may be used to produce a biomass. The systems and methods recycle liquid and can produce a high cell concentration harvested biomass.... Agent: Arizona Board Of Regents For And On Behalf Of Ariz Ona State University

20110275118 - Method of producing fatty acids for biofuel, biodiesel, and other valuable chemicals: The present invention relates to a method of producing fatty acids, by inoculating a mixture of at least one of cellulose, hemicellulose, and lignin with a microorganism strain and an algae strain, and growing said inoculated strains under successive aerobic-heterotrophic and either anaerobic-phototrophic or anaerobic-heterotrophic conditions creating symbiosis between the... Agent:

20110275120 - Fusion proteins with cleavable spacers and uses thereof: A polypeptide comprising a first protein domain, a second protein domain, and a dithiocyclopeptide spacer containing at least one protease cleavage site, wherein the dithiocyclopeptide is exogenous relative to the first or second protein domain, and wherein the first and second protein domains are operably linked by the dithiocyclopeptide. Also... Agent: University Of Southern California

20110275119 - Methods for ribosomal synthesis of polypeptides containing unnatural n-terminal groups and applications thereof: The present invention aims to synthesize a polypeptide having an unnatural structure at the N-terminus via a biosynthetic process by translation of amino acid sequence information encoded by a nucleic acid. A polypeptide having any amino acid at the N-terminus is synthesized by using an ARS ribozyme that catalyzes the... Agent:

20110275121 - Methods and compositions for production of recombinant protein in hbx-expressing mammalian cells: The method of the invention provides for producing a heterologous protein in mammalian host cells having nucleic acid encoding Hepatitis B X protein and the heterologous protein, by growing mammalian host cells selected from the group consisting of HKB11, CHO, BHK21, C2C12, and HEK293 cells, by growing mammalian host cells... Agent: Bayer Healthcare LLC

20110275122 - Thrombopoietic compounds: The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.... Agent: Amgen Inc.

20110275123 - Compositions and methods for generating antibodies: The compositions and methods of the present invention comprise the efficient and effective presentation of antigens to the appropriate components of the immune system resulting in the production of species-specific antibodies in vitro. In general, these compositions comprise one or more antigenic components together with a colloidal metal, optionally combined... Agent:

20110275124 - Reagents for reversibly terminating primer extension: This invention relates to the field of nucleic acid chemistry, more specifically to the field of compositions of matter that comprise triphosphates of modified 2′-deoxynucleosides and oligonucleotides that are formed when these are appended to the 3′-end of a primer, wherein said modifications comprise NH2 moiety attached to their 3′-hydroxyl... Agent:

20110275126 - Method for producing nucleic acid sample and method for producing nucleic acid amplification product using the same: Provided are a simple method for producing a nucleic acid sample that does not need to use high-risk chaotropic salt in large amounts, does not need to use a limited special carrier, and offers a superior level of safety; and a method for producing a nucleic acid amplification product using... Agent: Arkray, Inc.

20110275125 - System and method for processing a biological sample: Systems and methods for processing a biological sample are provided herein. For example, the system can be configured to deaggregate/declump a sample before, during, and/or after sample preparation and/or sample analysis. For example, the system can include a deaggregation device/system in communication with, for example, a nucleic acid amplification process... Agent: Life Technologies Corporation

20110275127 - Process for producing ethanol: A process for producing ethanol including a combination of biochemical and synthetic conversions results in high yield ethanol production with concurrent production of high value coproducts. An acetic acid intermediate is produced from carbohydrates, such as corn, using enzymatic milling and fermentation steps, followed by conversion of the acetic acid... Agent: Zeachem, Inc.

20110275128 - Use of whey for the manufacture of erythritol: Erythritol is prepared from whey. Whey is treated to form lactose, the lactose is treated to form glucose and galactose, the glucose and galactose are separated, and then the glucose is treated to form erythritol.... Agent: Pepsico, Inc.

20110275129 - Reduced by-product accumulation for improved production of isobutanol: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and... Agent: Gevo, Inc.

20110275130 - Fermentative glycerol-free ethanol production: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising... Agent: Technische Universiteit Delft

20110275131 - Methods of processing ensiled biomass: The invention relates to methods of processing ensiled biomass for production of bioethanol or other fermentation products and, in particular, to methods that do not require expensive pretreatment (e.g. heat or chemical pretreatment).... Agent: Inbicon A/s

20110275132 - Purification of bacterial antigens: Presented are methods of isolation of pili and pilus-like structures from Gram-positive bacteria including Streptococcus pneumoniae and compositions that include such isolated pili. These compositions are useful as immunogenic compositions for the production of antibodies and immunostimulation. Also presented are methods of inhibiting Streptococcus pneumoniae, and methods of identifying inhibitors... Agent: Novartis Ag

20110275133 - proteinaceous digestates: A method of aiding the digestion of a proteinaceous material, the method comprising adding to a sample of proteinaceous raw material a composition comprising fruit, fruit waste or an enzyme derived therefrom. A digestate liquor obtained by said method is also described.... Agent: Tanks And Vessels Industries Limited

20110275134 - Arrestin biosensor: The present invention relates to a novel biosensor. A resonance energy transfter (RET) biosensor comprising a beta(β)-arrestin tagged with a first and a second chromophore, wherein said first chromophore is a fluorophore and said second chromophore is a fluorophore or a bioluminophore is described.... Agent:

20110275135 - Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering recombination inside or outside of a cell using isolated and/or purified polypeptides and/or nucleic acid sequences from Alicyclobacillus acidocaldarius.... Agent: Battelle Energy Alliance, LLC

20110275136 - Amylase variants: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards... Agent: Novozymes A/s

20110275137 - Improving agent for neuropathic pain: An object of the present invention is to provide a substance which can be used as an active ingredient for improving neuropathic pain having a novel mechanism of action different from those of currently available agents and, therefore, provide an improving agent for neuropathic pain which rarely interacts with currently... Agent: National University Corporation Nagoya University,

20110275138 - Ketose 3-epimerase, its preparation and uses: An object of the present invention is to provide a novel ketose 3-epimerase, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for producing a ketose by using the enzyme. The present invention solves the above objects... Agent: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

20110275139 - Recombinant vaccinia virus having hepatitis c virus gene: Provided is a recombinant virus which is efficacious in preventing the onset of hepatitis C infection and has a high safety. Also provided is a vaccine for hepatitis C virus which contains the recombinant virus. A recombinant vaccinia virus which can express hepatitis C virus gene. The hepatitis C virus... Agent: Tokyo Metropolitan Organization For Medical Research

20110275140 - Apparatus and methods for production of biodiesel: A photobioreactor includes a cultivation zone configured to contain a liquid culture medium and facilitate growth of a microalgae biomass, a plurality of parallel edge-lit light transmitting devices mounted within the cultivation zone, and a collection zone oriented in relation to the cultivation zone such that at least a portion... Agent:

20110275141 - Anaerboic digester and a method for treating sludge in the digestor: A method for treating sludge in an anaerobic digester includes the steps of providing a pit in the ground that is lined with a seal and then forming cells in the pit into which a mixture of vegetal waste and sludge that has optionally undergone a pre-acidification stage is provided.... Agent:

20110275142 - Dandelion processes, compositions and products: Dandelion processes, compositions and products are provided. One process is a method of preparing dandelion that utilizes a species of a Taraxacum genus, the process including the steps of extracting and recovering a rubber and a carbohydrate from a dandelion root substantially simultaneously. The process employs a dandelion species that... Agent:

20110275143 - Microfluidic bubble logic devices: Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output... Agent: Massachusetts Institute Of Technology

20110275144 - Devices and methods for dual excitation raman spectroscopy: Spectroscopic analysis systems and methods for analyzing samples are disclosed. An analysis system may contain an electromagnetic radiation source to provide radiation, a spectroscopic analysis chamber to perform a coherent Raman spectroscopy (e.g., stimulated Raman or coherent anti-Stokes Raman spectroscopy), and a radiation detector to detect radiation based on the... Agent:

20110275145 - Manufacturing method and structure of cell cryopreservation tube: Manufacturing method of cell cryopreservation tube comprises the steps of providing a metal tubule having an inside wall and an outside wall. Smoothing the inside wall of the metal tubule thereby forming a smooth surface on the inside wall, and the roughness of the smooth surface is named the first... Agent:

20110275146 - Fusion proteins comprising dp-178 and other viral fusion inhibitor peptides useful for treating aids: The present invention relates to fusion peptides which exhibit potent anti-retroviral activity. The fusion peptides of the invention comprise a macromolecular carrier group fused to a gp41-derived DP178 (SEQ ID NO:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, or fragments, analogs or homologs of... Agent: Duke University

20110275147 - Hybridoma producing antibodies to lawsonia intracellularis: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test... Agent: Boehringer Ingelheim Vetmedica Gmbh

20110275148 - Hybridoma producing antibodies to lawsonia intracellularis: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test... Agent: Boehringer Ingelheim Vetmedica Gmbh

20110275149 - Hybridoma producing antibodies to lawsonia intracellularis: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test... Agent: Boehringer Ingelheim Vetmedica Gmbh

20110275150 - Compstatin analogs with improved activity: Compounds comprising peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation are disclosed. These compounds display improved complement activation-inhibitory activity as compared with currently available compounds. Isolated nucleic acid molecules encoding the peptides are also disclosed.... Agent:

20110275151 - Methods and compositions for repair of cartilage using an in vivo bioreactor: Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of... Agent:

20110275152 - Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1−/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF9, or... Agent:

20110275153 - Cryogenic storage device: A cryopreservation device for storing reproductive biological material is provided. The device comprises an elongate first member includes an elongate first member extending between a distal end and a proximal end, a first bulge portion disposed around a circumference of the first member, and a trough defined within the first... Agent: Vance Products Inc., D/b/a Cook Urological Inc.

20110275154 - Derivatized peptide-conjugated (meth) acrylate cell culture surface and methods of making: A synthetic cell culture surface, prepared from a mixture of at least three (meth)acrylate monomers where one of the monomers has an N-hydroxysuccinimide moiety is provided, which supports the growth of cells including undifferentiated human embryonic stem cells in defined media. Methods for preparing the cell culture surface is also... Agent:

20110275155 - Entrapped stem cells and uses thereof: The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal... Agent:

20110275157 - Composition for reprogramming somatic cells to generate induced pluripotent stem cells, comprising bmi1 and low molecular weight substance, and method for generating induced pluripotent stem cells using the same: Provided is a composition for reprogramming somatic cells to generate embryonic stem cell-like cells, comprising: a) a Bmi1 (B cell-specific Moloney murine leukemia virus integration site 1) protein or a nucleic acid molecule encoding the Bmi1 protein; and b) at least one low molecular weight substance selected from the group... Agent: Korea University Research And Business Foundation

20110275156 - Delivery of dna or rna via gap junctions from host cells to target cells and a cell-based delivery system for antisense or sirna: A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the... Agent: The Trustees Of Columbia University In The City Of New York

20110275158 - Method of modifying target region in host dna and selectable marker cassette: A method of modifying a target region in a host DNA using a donor DNA: wherein the donor DNA having regions homologous to a 5′-side region outside of the target region in the host DNA, a 3′-side region outside of the target region in the host DNA and a first... Agent: Kao Corporation

  
11/03/2011 > 124 patent applications in 68 patent subcategories. recently filed with US Patent Office

20110269112 - Evaluation and preservation solution: An evaluation and preservation solution for human and animal organs, tissues and parts thereof is described, wherein it comprises serum albumin at a concentration of 55-105 g/L, a scavenger and coating compound, preferably dextran compounds and derivatives thereof having essentially the same structure at a concentration of 1-55 g/L weight,... Agent: Xvivo Perfusion Ab

20110269113 - Method of inhibiting biomaterial-induced procoagulant activity using complement inhibitors: Methods for reducing or eliminating biomaterial-induced procoagulant activity in blood subjected to extracorporeal treatment that exposes the blood to the biomaterial are disclosed. The methods involve treatment of the blood, or the extracorporeal biomaterial, or both, with a complement inhibitor to inhibit C5a/C5aR-mediated tissue factor formation in the blood.... Agent:

20110269114 - Yeast growth maximization with feedback for optimal control of filled batch fermentation in a biofuel manufacturing facility: The present invention provides novel techniques for controlling biofuel production processes. In particular, estimated yeast activity values are determined by yeast activity sensors. These estimated yeast activity values are used to bias predicted yeast activity values from an inferential dynamic predictive model. The biased predicted yeast activity values are in... Agent: Rockwell Automation Technologyies, Inc.

20110269116 - Cell line from rousettus as host cell for pathogen amplification: The present invention relates to permanent cell lines from chiropterans suitable for amplification and production microbial agents, preferably viruses, and its use for diagnostic or therapeutic purposes.... Agent: Probiogen Ag

20110269115 - Heated assays for influenza: Methods of increasing specific binding, decreasing non-specific binding, and reducing false-positive interaction in solid phase assays for influenza are disclosed. In the methods, the solid phase apparatus (lateral flow solid phase apparatus or capillary flow solid phase apparatus) is subjected to elevated heat subsequent to application of a test sample... Agent: Response Biomedical Corporation

20110269117 - Methods for direct fluorescent antibody virus detection in liquids: The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as... Agent:

20110269118 - Methods for identifying cells by combinatorial fluorescence imaging: A method of identifying the taxonomic or functional classification of cells in situ involves labeling the cells with a set of nucleic acid probes and performing combinatorial fluorescence microscopic imaging. The set of probes contains groups of either two or three probes that bind to a taxon-specific or function-specific nucleotide... Agent: The Marine Biological Laboratory

20110269119 - Encoding text into nucleic acid sequences: Methods and apparatus are disclosed herein for encoding human readable text conveying a non-genetic message into nucleic acid sequences with a substantially reduced probability of biological impact and decoding such text from nucleic acid sequences. In one embodiment, each symbol of a symbol set of human readable symbols uniquely maps... Agent: Synthetic Genomics, Inc.

20110269122 - Hereditary hemochromatosis gene: The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts... Agent: Bio-rad Laboratories, Inc.

20110269121 - Lab-on-a-pipette: This invention generally relates to an integrated ‘Lab-on-a-Pipette™’ which will provide sample-to-answer single cell genetic diagnosis for preimplantation genetic diagnosis (PGD) and other forms of single cell analysis (SCA). SCA is a quickly growing field with substantial impact in prenatal testing, cancer biopsies, diabetes, stem cell research, and our overall... Agent:

20110269120 - Methods and compositions for detecting promoter activity and expressing fusionproteins: The present invention provides nucleic acid molecules comprising one or more nucleic acid sequences encoding a polypeptide having a detectable activity. The present invention also provides methods of joining such nucleic acid molecules to nucleic acid molecules to be assayed for promoter activity. The present invention also relates to methods... Agent: Life Technologies Corporation

20110269130 - Antibiotice susceptibility profiling methods: The invention provides methods for the rapid determination of the antibiotic susceptibility of a microorganism, such as, an infectious microorganism in a biological sample, using fluorescence in situ hybridization (“FISH”). Methods of the invention may be applied to the rapid identification, typing, antibiotic susceptibility determination, and/or antibiotic minimum inhibitory concentration... Agent:

20110269129 - Binary probe system for sensitive detection of target analytes: The present disclosure encompasses systems, and their methods of use, for detecting a target analyte, the systems comprising: (a) a first oligonucleotide probe comprising a reporter oligonucleotide-binding arm complementary to the nucleotide sequence of a first region of a reporter oligonucleotide and an analyte-binding arm selectively binding to a first... Agent: University Of Central Florida Research Foundation, Inc.

20110269133 - Compositions and methods for detecting the presence of cryptosporidium parvum in a test sample: The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Cryptosporidium organisms, and Cryptosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligonucleotides of the present invention include hybridization assay probes, helper probes and amplification primers.... Agent: Gen-probe Incorporated

20110269126 - Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders: The present application provides methods and nucleic acids for the detection and differentiation of breast cell proliferative disorders. This is achieved by the analysis of the methylation of a panel of genes, or subsets thereof. The invention may be used for the detection and/or differentiation of a variety of tissue... Agent: Epigenomics Ag

20110269128 - Forensic identification: The invention provides allelic ladder mixtures and individual alleles suitable for use in such mixtures. The allelic ladder mixtures give improved identification and distinguishing capabilities, particularly suitable in forensic investigations.... Agent: Forensic Science Service Ltd.

20110269123 - Marker for gastric cancer and method for detecting gastric cancer: In embodiments the expression or methylation of the PAX5 gene is used as a marker for the diagnosis and prognosis of gastric cancer. In further embodiments methods for detecting gastric cancer are disclosed as are methods for inhibiting the growth of gastric cancer.... Agent: The Chinese University Of Hong Kong

20110269127 - Means and method for determining tumor cell percentage in a sample: The invention provides a method for determining the percentage of tumor cells in a sample of an individual, preferably a breast sample. More specifically, the invention provides one or more genes than can be used to determine the percentage of tumor cells. The invention further provides a set of probes,... Agent:

20110269125 - Methods and compositions for predicting development of atopic diseases: The present invention relates to methods of testing for allergic diseases and methods for screening candidate compounds as therapeutic agents for allergic diseases. In particular the present invention provides genetic markers useful for the prediction of an individual's susceptibility to and/or the molecular diagnosis of atopic diseases such as bronchial... Agent:

20110269132 - Methods for determining dysregulation of methylation of brain expressed genes on the x chromosome to diagnose autism spectrum disorders: The discovery that alterations in methylation, which can cause one or more genes on the single X chromosome in males to be partially silenced or overexpressed, constitute a predisposition to autism spectrum disorders is generally disclosed herein. These alterations provide the rationale and basis for methods to diagnose autism spectrum... Agent: Greenwood Genetic Center, Inc.

20110269124 - Methods, primers, probes and kits useful for the detection of braf mutations: The present invention relates to methods, primers and probes useful for detecting the presence of mutant BRAF sequences in a sample, specifically for detecting the presence of the BRAF V600E, V600D, V600K, and V600M mutations.... Agent: Response Genetics

20110269131 - Substrate for manufacturing disposable microfluidic devices: Embodiments of the present invention relate to a UV-curable polyurethane-methacrylate (PUMA) substrate for manufacturing microfluidic devices. PUMA is optically transparent, biocompatible, and has stable surface properties. Embodiments include two production processes that are compatible with the existing methods of rapid prototyping, and characterizations of the resultant PUMA microfluidic devices are... Agent:

20110269136 - Biomarker and composition for diagnosis of preeclampsia and method for using the same: The present invention relates to a biomarker and a composition for diagnosis of preeclampsia. In accordance with one aspect of the present invention, there is provided a biomarker for diagnosis of preeclampsia using an enzyme selected from the group consisting of placental chondroitin 4-O-sulfotransferase 1 (C4ST), chondroitin 6-sulfotransferase (C6S), heparan... Agent:

20110269139 - Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators: The present invention provides methods useful for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, and diagnostic methods and kits thereof.... Agent: Bristol-myers Squibb Company

20110269135 - Device for analysing a chemical or biological sample: A device for analysing a clinical sample comprises at least one depot chamber for receiving one or more reagents and at least one process chamber, whereas the process chamber is integrated in a first support member and the depot chamber is integrated in at least a second support member, whereas... Agent: Carpegen Gmbh

20110269138 - Method for detecting methicillin-resistant staphylococcus aureus (mrsa) strains: d

20110269140 - Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria: The present invention relates generally to detection of antibiotic-resistant bacteria in a sample. In particular, the invention provides methods, compositions and kits for detecting and analyzing methicillin-resistant Staphylococcus aureus (MRSA) and other methicillin-resistant bacteria in a sample.... Agent: Molecular Detection, Inc.

20110269137 - Rapid and efficient assay to assess the sequence and size of 3' ends of polynucleotides: Described herein is an efficient, highly reproducible approach to assess poly(A) tail length on a mRNA specific basis. The embodiments herein have led to the development of a versatile, easy to use kit for biomedical researchers to address the impact of changes in poly(A) tail length in the post-transcriptional regulation... Agent:

20110269134 - Reagents and methods for detecting neisseria gonorrhoeae: This invention provides compositions and methods for detecting Neisseria gonorrhoeae in a sample. This invention also provides related reaction mixtures, kits, systems, and computers.... Agent: Roche Molecular Systems, Inc.

20110269141 - Target protein and target gene for drug discovery, and screening method: The problems of the present invention are to provide target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. The present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable... Agent: Reverse Proteomics Research Institute Co., Ltd.

20110269142 - Clinical method for individualized epithelial cancer screening involving ercc5 and igf2r genetic testing and gene-environment interactions: A system for determining individualized risk of developing aerodigestive cancers or cancers of the liver is described. Methods and compositions for assessing ERCC5 and/or IGF2R genetic variation and expression and their effects in view of certain environmental exposures in determining the risk of an individual for developing one or more... Agent: President And Fellows Of Harvard College

20110269143 - Genetic variants as markers for use in urinary bladder cancer risk assessment, diagnosis, prognosis and treatment: It has been discovered that certain genetic variants correlate with risk of urinary bladder cancer in humans. The invention relates to use of such variants in methods of disease management of urinary bladder cancer, including various diagnostic methods.... Agent: Decode Genetics Ehf.

20110269145 - Cancer risk biomarkers: The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular cancer or predisposition to cancer.... Agent: University Of Toledo

20110269144 - Ryanodine receptor polypeptides: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial... Agent: E. I. Du Pont De Nemours And Company

20110269146 - Expression vectors and cell lines expressing vascular endothelial growth factor d, and method of treating melanomas: This invention relates to expression vectors comprising VEGF-D and its biologically active derivatives, cell lines stably expressing VEGF-D and its biologically active derivatives, and to a method of making a polypeptide using these expression vectors and host cells. The invention also relates to a method for treating and alleviating melanomas... Agent: Vegenics Limited

20110269149 - Method for quantification of body internal concentration of protein-based drug: i

20110269147 - Methods, devices, and systems for glycated hemoglobin analysis: Methods, devices, and systems for measuring the concentration of glycated hemoglobin (HbA1c) in a blood sample are provided. A blood sample may be contacted with a lysing agent, an assay to measure total Hb, and an assay to measure HbA1c, which comprises donor and acceptor dyes attached to a Hb... Agent: Bayer Healthcare LLC

20110269148 - Nanoaggregate embedded beads conjugated to single domain antibodies: A nanoaggregate embedded bead is formed from an inner core formed of comprising metallic nanoparticles and Raman active reporter molecules, an outer shell, and single-domain antibodies to target the bead to a specific target. The nanoaggregate embedded bead may be used in methods to detect analytes or pathogens in biological... Agent: National Research Council Of Canada

20110269152 - Anchoring/capturing system for selecting or analyzing a cho cell according to a product secreted by the cho cell: An anchoring/capturing system for selecting or analyzing a CHO cell according to a product secreted by the CHO cell is described. The anchoring/capturing system comprises a first antibody or a first antigen-binding fragment for anchoring to the extracellular surface of the CHO cell, and a second antibody or a second... Agent: Miltenyi Biotec Gmbh

20110269153 - Immunoassay device with improved sample closure: An apparatus and method for sealing a fluid sample collection device, comprising: loading a fluid sample collection device with a fluid sample, said device comprising a housing having at least one substantially planar surface that includes an orifice in fluid communication with an internal fluid sample holding chamber which terminates... Agent: Abbott Point Of Care Inc.

20110269155 - Detecting antigen responsive cells in a sample: The present invention relates to methods for detecting antigen responsive cells in a sample using multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (NHC). Further, the present invention relates to the use of the present multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (MHC), for detecting... Agent: Stichting Sanquin Bloedvoorziening

20110269154 - Methods for diagnosis, prognosis and methods of treatment: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that... Agent: Nodality, Inc.

20110269150 - Compositions and methods for predicting cardiovascular events: The present invention provides compositions, devices, kits, and methods for determining the risk of peri-operative cardiovascular events or predicting cardiovascular events associated with angioplasty. In certain embodiments, the present invention provides methods, compositions, kits, and devices configured for determining the value of at least two markers selected from myeloperoxidase (MPO),... Agent: Cleveland Heart Lab

20110269156 - Nonseparation assay methods: Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support as is a member of a specific binding pair for capturing an analyte from a sample. An activator compound that activates the chemiluminescent... Agent: Beckman Coulter, Inc.

20110269151 - Centrifugal micro-fluidic device and method for immunoassay: A centrifugal micro-fluidic device and an immunoassay method using the same are provided. The micro-fluidic device includes at least one micro-fluidic structure, the micro-fluidic structure including: a sample chamber receiving a fluid sample; a first reaction chamber which is connected with the sample chamber and contains at least one labeling... Agent: Samsung Electronics Co., Ltd.

20110269157 - Immunological test for detecting autoantibodies against testicular antigens: The present invention discloses an immunological test for the detection and specific determination of autoantibodies against testicular antigens which are associated with inflammation-related fertility disorders of male mammals in a biological sample of a male mammal, in particular the detection of testicular ER-60 autoantibodies and/or transferrin autoantibodies. The immunological test... Agent: Justus-liebig-universitat Giessen

20110269158 - Use of s-erbb-3 as a marker for cancer: The present invention relates to a method aiding in the assessment of cancer. It discloses the use of s-ErbB-3 as a universal marker of different cancer types. Measurement of s-ErbB-3 can, e.g., be used in the early detection or diagnosis of cancer or in the surveillance of patients who undergo... Agent:

20110269159 - Reagents for reducing leukocyte interference in immunoassays: Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample such as a whole blood sample with one or more leukocidal reagents that reduce or eliminate the metabolic activity of leukocytes,... Agent: Abbott Point Of Care Inc.

20110269160 - Method and medium for detecting the presence or absence of staphylococcus aureus in a test sample: A presence/absence test for Staphylococcus aureus (S. aureus) involves placing a first generation test sample in a solution that will clot in the presence of S. aureus. The solution contains components that will selectively grow S. aureus and also contains clotting factors that will react with S. aureus, if S.... Agent: Pilots Point LLC

20110269161 - Methods, compositions and kits for high throughput kinase activity screening using mass spectrometry and stable isotopes: A mass-spectrometry-based method and substrates are provided herein for large scale kinome activity profiling directly from crude lysates using 90 chemically synthesized peptide substrates with amino acid sequences derived from known phosphoproteins. Quantification of peptide phosphorylation rates was achieved via the use of stable isotope labeled synthetic peptides. Half of... Agent: President And Fellows Of Harvard College

20110269162 - Ubiquitin proteasome system profiling for diagnosis of chronic liver disease: Provided herein are methods for the diagnosis, staging, prognosis, or management of liver disease, e.g. chronic liver disease, and other diseases using profiles of the ubiquitin-proteasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of patients with... Agent: Quest Diagnostics Investments Incorporated

20110269163 - Method and medium for detecting the presence or absence of staphylococcus aureus in a test sample: A presence/absence test for Staphylococcus aureus (S. aureus) involves placing a first generation test sample in a solution that will clot in the presence of S. aureus. The solution contains components that will selectively grow S. aureus and also contains clotting factors that will react with S. aureus, if S.... Agent: Pilots Point LLC

20110269164 - Measuring device, measuring method, and program: A measuring device (1) is provided, comprising a measurement section (5) for measuring a specific constituent in a biological sample, an input accepting section (2) for accepting an input of an estimated value of subject's, measurement result, a coincidence degree determining section (61) for referencing data of an estimated value... Agent: Arkray, Inc.

20110269165 - Lactic acid bacteria and their cellular components inducing immunoregulatory function, and method of obtaining the same: To provide a microorganism and an ingredient thereof that contribute to prevention and treatment of immune diseases including allergy, autoimmune diseases and inflammatory bowel diseases (e.g., large-intestinal ulcer), a method of effectively selecting the microorganism, and a method of efficiently inducing immunoregulatory cells that play an important role on maintaining... Agent:

20110269167 - Medical apparatus for extracorporeal blood treatment and method for determining a blood parameter value in a medical apparatus thereof: A medical apparatus for extracorporeal blood treatment and a method for determining blood parameter value have been provided. The medical apparatus has a control unit (9) configured for taking from a storage memory (10) a plurality of blood parameter value measures each made through the sensors (8) provided on the... Agent: Gambro Lundia Ab

20110269173 - Method for producing polarized retinal progenitor cells from pluripotent stem cells and their differentiation into retinal pigment epithelium cells: In the method according to the invention pluripotent stem cells are differentiated into polarized retinal progenitor cells by first culturing pluripotent stem cell colonies in three-dimensional cell culture embedded in a proteinaceous gel comprising at least two proteins selected from the group consisting of Laminin, Collagen IV Entactin and Perlecan... Agent: Technische Universit&#xe4 T Dresden

20110269171 - Methods and materials for using nkap polypeptide expression levels or patterns to detect or assess cancer: This document relates to methods and materials involved in detecting or assessing cancer (e.g., ovarian cancer). For example, methods and materials involved in using NKAP polypeptide expression levels and patterns to diagnose cancer, assess cancer survival, and assess cancer treatment options are provided.... Agent:

20110269175 - Methods for sorting particles: A method of sorting stained particles in a flow cytometer by generating a mathematical model based upon extracted features of waveform pulses produced in response to the stained particles. Waveform pulses can then be analyzed to determine the probability the stained particles belong in either a first or a second... Agent: Inguran, LLC

20110269172 - Micro-electrode grid array for top and bottom recording from samples: m

20110269170 - Ph sensitive metal nanoparticle and preparation method: The present invention relates to a pH sensitive particle, a method of preparation thereof, and a use thereof. More particularly, the invention provides a pH sensitive metal nanoparticle and its use for medical treatment utilizing cell necrosis during photothermal therapy. The pH sensitive metal nanoparticle based on this invention consists... Agent: Postech Academy-industry Foundation

20110269168 - Processes and kits for determining multi-drug resistance of cells: This invention relates to multi-drug resistance (MDR) in cells, and the use of certain xanthene compounds for determining drug resistance in cells and the effect of test compounds on cell membrane transport by the membrane transporters MDR1, MRP and BCRP. Processes and kits for making these determinations and measuring these... Agent:

20110269169 - Pseudomonas alcaliphila mbr and its application in bioreduction and biosorption: The present invention relates to microbiology technology field. More particularly, it relates to Pseudomonas alcaliphila MBR CGMCC 2318 which has the ability to reduce and adsorb metal and nonmetal ions. It also relates to methods of bioreduction and biosorption using the said strain by means of its property of reducing... Agent: Chengdu Institute Of Biology, Chiness Acdemy Of Sciencess

20110269174 - Regulators of nfat: Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction,... Agent: Immune Disease Institute, Inc.

20110269166 - Sealing surface sampling probe applied to blood spots and tissues: A sample assembly includes a stack of a sample and a hydrophobic elastic layer located on the back side surface thereof or a filter layer. The sample may include a biological material or a chemical, and can include an absorptive material. The filter layer includes an absorptive material in which... Agent: Ut-battelle, LLC

20110269176 - Methods for assaying responses to vaccines: The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an... Agent: Sanofi Pasteur Vaxdesign Corporation

20110269177 - Antimicrobial agent and method for the production thereof: Provided are antimicrobial agents produced from Burkholderia cepacia complex (Bcc) bacteria, in particular from bacteria which comprise a cluster of polyketide synthesis genes. Also provided is use of the antimicrobial agents in the treatment of disease. Further provided are methods for producing antimicrobials, methods for detecting antimicrobial producing bacterial strains... Agent: University College Cardiff Consultants Ltd. Cardiff School Of Biosciences Cardiff University

20110269179 - Coliform detection process and kit for use therein: A process comprises (a) providing (1) at least one sample suspected of comprising at least one coliform strain, (2) at least one culture device comprising at least one culture medium that is hydrated or hydratable, and (3) at least one particulate concentration agent that is substantially optically transparent when in... Agent:

20110269178 - Fluorescent cdk inhibitors for treatment of cancer: Disclosed are molecules and their synthesis. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.... Agent: Georgetown University

20110269180 - Prokaryotic xylose isomerase for the construction of xylose fermenting yeasts: The present invention relates to the use of nucleic acid molecules coding for a bacterial xylose isomerase (XI), preferably coming from Clostridium phytofermentans, for reaction/metabolization, particularly fermentation, of recombinant microorganisms of biomaterial containing xylose, and particularly for the production of bioalcohols, particularly bioethanol, by means of xylose fermenting yeasts. The... Agent:

20110269181 - Method and system for continuous biotransformation: One embodiment of the present invention discloses a method for continuous biotransformation. The method is continuously supplying viable biocatalyst cells or biocatalyst biomolecules to a bioreactor containing substrate mediums, so as to mediate the substrate mediums to be converted into the desired bioproducts.... Agent: Chung Yuan Christian University

20110269182 - Method for selectively modifying a protein: The present invention relates generally to a novel method of introducing property modifying groups to a protein. In particular, the present invention relates to the derivatization of lysine residues, as well as new conjugates of growth hormones with improved pharmacological properties, and methods for their preparation and use in therapy.... Agent: Novo Nordisk A/s

20110269185 - Compositions and methods for producing fermentation products and residuals: The present invention provides compositions and methods designed to increase value output of a fermentation reaction that yields a first product, intended for commercialization, such as ethanol, and a fermentation residual used, for example, as animal feed. The methods involve using microorganisms in the fermentation process that have been modified... Agent:

20110269184 - Method for controlling plasmid copy number in e.coli: Host vector system and methods for plasmid DNA and recombinant protein production. The system allows copy number control of a ColE1 plasmid in E. coli by an RNA molecule that is transcribed from the host's genome and that interacts with plasmid-transcribed RNAI or RNAII. The system can be extended to... Agent: Boehringer Ingelheim Rcv Gmbh & Co. Kg

20110269183 - Recombinant microorganism having an ability of using sucrose as a carbon source: The present invention relates to a recombinant microorganism capable of metabolizing sucrose, and more particularly to a recombinant microorganism capable of metabolizing sucrose in which a gene encoding sucrose phosphotransferase and/or a gene encoding sucrose-6-phosphate hydrolase is introduced or to a recombinant microorganism capable of metabolizing sucrose in which a... Agent: Korea Advanced Institute Of Science And Technology

20110269186 - Antibodies against vascular endothelial growth factor receptor-1: Monoclonal antibodies that are specific for vascular endothelial growth factor receptor 1 (VEGFR-I). This invention also provides nucleotide sequences encoding and amino acid sequences comprising variable heavy and light chain immunoglobulin molecules, including sequences corresponding to the complementarity determining regions of CDR1, CDR2, and CDR3. The invention also provides methods... Agent: Imclone LLC

20110269187 - High affinity human antibodies to human il-18 receptor: An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or... Agent: Regeneron Pharmaceuticals, Inc.

20110269189 - Method for post-extracting high-acyl gellan gum: Disclosed is a method for extracting high acyl gellan from the fermentation broth containing gellan gum with a low production cost and high quality of products, comprising the following steps: (1) Treatment of the fermentation broth with an enzyme; (2) flocculation of the treated fermentation broth with acid; (3) wash... Agent: Zhejiang Dsm Zhongken Biotechnology Co Ltd.

20110269188 - Polypeptides having feruloyl esterase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having feruloyl esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes, Inc

20110269190 - Barriers for facilitating biological reactions: The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.... Agent: Northwestern University

20110269192 - Loop-shaped primer used in nucleic acid amplification and the use thereof: Loop-shaped primer used in nucleic acid amplification is an oligonucleotide with 3-20 bases in both 3′ and 5′ ends which can be combined together to form a double-strand under appropriate conditions, resulting in the primer forming a stem-loop structure. The double-stranded structure is opened and the stem-loop structure dissolves when... Agent:

20110269193 - Method of amplifying a target nucleic acid by rolling circle amplification: Provided is a method of amplifying a nucleic acid using rolling cyclic amplification (RCA), including amplifying a nucleic acid together with formation of a single-strand circular DNA template using RCA by reacting a reaction solution including: (a) two hairpin oligos, (b) a target nucleic acid, (c) a DNA ligase, (d)... Agent: Samsung Electronics Co., Ltd.

20110269191 - Thermal cycler for pcr including temperature control bladder: Methods and devices for performing chemical reactions under controlled temperature are described. In one embodiment, the devices provided by the invention comprise a housing diminished hold a reaction chamber disposed within an interior volume of the housing. The reaction chamber has thermally conductive interior and exterior surfaces defining an internal... Agent:

20110269194 - Materials and methods for nucleic acid fractionation by solid phase entrapment and enzyme-mediated detachment: Materials and methods are provided for the gel-free fractionation of polynucleotide molecules. According to the present invention, fractionation is size-based or sequence-based.... Agent: Swift Biosciences, Inc.

20110269195 - Plants with reduced activity of a starch phosphorylating enzyme: The present invention relates to plant cells and plants, which are genetically modified, wherein the genetic modification leads to the reduction of the activity of a starch phosphorylating OK1 protein in comparison with corresponding wild type plant cells or wild type plants that have not been genetically modified. Furthermore, the... Agent: Bayer Cropscience Ag

20110269196 - Coenzyme q10 production using sporidiobolus johnsonii: A new isolate of Sporidiobolus johnsonii that is capable of producing over a significant percentage of CoQ10 upon the addition of para-hydroxy benzoic acid in stationary phase, and a method of obtaining CoQ10 from the S. johnsonii isolate which can be scaled up to industrial levels.... Agent: Syracuse University

20110269197 - Alcohol production process: The invention relates to methods for improving the efficiency of carbon capture in microbial fermentation of a gaseous substrate comprising CO and/or H2. In certain aspects the invention relates to improving the efficiency of carbon capture in the microbial fermentation of gaseous substrate comprising CO and/or H2 to produce alcohol(s)... Agent: Lanza Tech New Zealand Limited

20110269198 - Methods for control of flux in metabolic pathways: The invention pertains to a method for preparing cells that can be used as biocatalysts by inducing in them a growth-decoupled state, in which interferase inhibits the expression of genes except the ones that code for the pathway enzymes of interest. mRNAs that code for interferase-resistant products are overexpressed in... Agent: Greenlight Biosciences, Inc.

20110269199 - Alcohol dehydrogenases (adh) useful for fermentive production of lower alkyl alcohols: The invention relates to suitable candidate ADH enzymes for production of lower alkyl alcohols including isobutanol. The invention also relates to recombinant host cells that comprise such ADH enzymes and methods for producing lower alkyl alcohols in the same.... Agent: Butamax(tm) Advanced Biofuels LLC

20110269202 - Genetically engineered yeast for the production of biofuels: Compositions and methods are provided for generating biofuels by fermentation from carbon sources other than glucose using genetically engineered yeast strains. For example, a Saccharomyces strain which is capable of converting glucose to ethanol but not of metabolizing N-acetyl glucosamine is genetically engineered to utilize N-acetyl glucosamine as a nutrient... Agent: New England Biolabs, Inc.

20110269200 - Increased ethanol production by genetic engineering of microorganisms to express hemoglobin: The present disclosure describes novel bacterial strains which express a pyruvate decarboxylase gene and at least one alcohol dehydrogenase gene from a bacteria of the genus Zymomonas and also express a hemoglobin gene from a bacteria of the genus Vitreoscilla. The present disclosure further describes methods for producing fermentation products... Agent:

20110269201 - Redirected bioenergetics in recombinant cellulolytic clostridium microorganisms: Compositions and methods are provided for redirecting metabolic solventogenesis pathways to enhance the product yield from fermentation of biomass. Clostridium microorganism pathways are modified to extend the growth phase and prevent inhibition of acetaldehyde while bypassing the synthesis of acetyl CoA.... Agent: Qteros, Inc.

20110269203 - Lipogenic zooplankton for the conversion of cellulosic biomass to biofuel: The present invention to provides a method for the conversion of biomass comprising cellulosic or carbohydrate polymers, into lipids useful for the production of biofuels. The method is achieved by providing the biomass to a culture of lipogenic zooplankton in a contained space, whereby the zooplankton consume the biomass, thereby... Agent:

20110269204 - Microorganisms and methods for the biosynthesis of propylene: The invention provides non-naturally occurring microbial organisms having a propylene pathway. The invention additionally provides methods of using such organisms to produce propylene.... Agent:

20110269206 - Polypeptides having catalase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having catalase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes, Inc

20110269205 - Use of enzyme catalysts in co2 pcc processes: A method for processing a stream enriched in CO2 from a gas by the action of an absorbent in the stream includes desorbing CO2 from the stream by application of heat to the stream to desorb the CO2 and regenerate the absorbent in a reaction system that includes reconstitution of... Agent: Commonwealth Scientific And Industrial Research Organisation

20110269207 - Cell and biofactor printable biopapers: Disclosed herein is a structure having: a porous polymeric film permeated by a first extracellular matrix material; and a topcoat layer comprising a second extracellular matrix gel disposed on the film. Also disclosed herein is a method of: providing a porous polymeric film; permeating the film with a first extracellular... Agent: The Government Of The United States Of America, As Represented By The Secretary Of The Navy

20110269208 - Cross-linked polymer network formed by sequential cross-linking: The convention concerns methods for preparing a cross-linked polymer network comprising: forming a plurality of cross-links in a polymer network by (i) addition polymerization or (ii) ionic polymerization or (iii) partial radical polymerization of the polymer network to produce an intermediate polymer network, and forming further cross-links in the polymer... Agent: The Trustees Of The University Of Pennsylvania

20110269209 - Plasticized mycelium composite and method: A method of making a plasticized mycelium structure, including dissolving a soluble polymer in a liquid thereby forming a polymer solution of polymer particles. The polymer solution is combined with a fungal inoculum capable of growing hyphae in the presence of an aggregate. The resulting mixture is allowed to grow... Agent:

20110269210 - Alpha-amylase variants with altered properties: Disclosed are compositions comprising variants of alpha-amylase that have alpha-amylase activity and that exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions generally comprise at least one of an additional enzyme, a detergent,.a surfactant, a chelator, an oxidizing agent, an acidulant, an alkalizing... Agent: Danisco US Inc.

20110269211 - Modified dna polymerases: The present invention provides, among other things, modified DNA polymerases containing amino acid alterations based on mutations identified in directed evolution experiments designed to select enzymes that are better suited for applications in recombinant DNA technologies.... Agent: Kapa Biosystems

20110269212 - Fungal endoglucanases, their production and use: Novel fungal endoglucanases with substantial performance at low temperatures are disclosed. The endoglucanases are conveniently produced by recombinant technology, and means for their production are described. The endoglucanases are used for treating cellulosic material, especially in textile industry, e.g. in biofinishing or biostoning. They may also be used in detergents,... Agent: Ab Enzymes Oy

20110269213 - Fungal endoglucanases, their production and use: Novel fungal endoglucanases Cel5 and Cel2 are disclosed. The endoglucanases are conveniently produced by recombinant technology, and means for their production are described. The endoglucanases are used for treating cellulosic material, especially in textile industry, e.g. in biofinishing or biostoning. They may also be used in detergents, in animal feed... Agent: Ab Enzymes Oy

20110269214 - Foamed mycelium structure and method: A method of making a molded part, including forming a liquid aggregate from a mixture of finely ground aggregate and a fluid. A mixture of a fungal inoculum and the liquid aggregate is formed. Nanoparticles are homogenously distributed throughout the mixture. The mixture is inserted into a mold cavity. Live... Agent:

20110269215 - Biofuel production: Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity... Agent: Bio Architecture Lab, Inc.

20110269216 - Everninomicin biosynthetic genes: This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin... Agent: Schering Corporation

20110269217 - Hazardous substance adsorbing tablet: A hazardous substance adsorbing tablet prepared by direct compression of a dry powder mixture which includes a porous particulate adsorbent having an average particle diameter of 100 μm or less and containing 200 mesh pass particles in an amount of more than 80% by weight, and a particulate binder having... Agent: National Institute For Agro-environmental Sciences

20110269218 - Structural member formed from mycelium and method: A method of making a hardened elongate structure, including growing a live mycelium mat having branching hyphae. The live mycelium mat is layered to form a multi-layered structure. The hyphae are allowed to grow inward into the multi-layered structure such that the hyphae are interwoven throughout the multi-layered structure. The... Agent:

20110269219 - Method for increasing algae growth and the use thereof in production of algae-derived biofuels and other chemical: A method of increasing yield of cultivated algae, which entails the step of cultivating one or more species of algae in the presence of one or more species of PPFM bacteria, for at least a portion of the algae cultivation.... Agent: Gst Growth, LLC

20110269220 - Gordonia sihwensis and uses thereof: Strains of Gordonia sihwensis and uses thereof are described herein. G. sihwensis can sequester and/or biodegrade hydrocarbons. In particular, G. sihwensis may be used in remediation of drill cuttings coated with drilling fluid and soil or sludges contaminated with oil contaminants.... Agent: Chevron U.s.a. Inc.

20110269221 - Flow channel device, complex permittivity measuring apparatus, and dielectric cytometry system: A flow channel device, a complex permittivity measuring apparatus, and a dielectric cytometry system are provided which can improve the measurement accuracy. A constriction portion having a constricted space is disposed between an inflow port and an outflow port of a flow channel. Electrodes are arranged between the inflow port... Agent: Sony Corporation

20110269222 - Immunoassay device with improved sample closure: An apparatus and method for sealing a fluid sample collection device, comprising: loading a fluid sample collection device with a fluid sample, said device comprising a housing having at least one substantially planar surface that includes an orifice in fluid communication with an internal fluid sample holding chamber which terminates... Agent: Abbott Point Of Care Inc.

20110269223 - Corrosion inhibition: The present invention relates to a methods, products and uses for inhibiting corrosion. A provided method comprises the steps of: a) subjecting cellulosic biomass to hydrolysis to obtain a hydrolysate liquid; b) optionally, subjecting the hydrolysate liquid from step a) to one or more of the steps of further hydrolysis,... Agent: Sekab E-technology Ab

20110269224 - Tissue container for molecular and histology diagnostics incorporating a breakable membrane: A container for storing a biological sample for molecular diagnostic testing and/or histological testing is provided. The container includes a first chamber for receiving a sample holder therein, a second chamber, and a closure for enclosing the container. A breakable membrane, such as a piercable foil, extends within the container... Agent: Becton, Dickinson And Company

20110269225 - Crustacean expression vector: Methods and constructs for genetic manipulation of one or more of shrimp, shellfish, mollusks, and fish are disclosed. The nucleic acid construct includes a promoter and an internal ribosome entry site of an insect picomavirus, such as a cricket paralysis-like picomavirus. One or more open reading frames can be operably... Agent:

20110269226 - Microfluidic continuous flow device for culturing biological material: The present invention refers to a microfluidic continuous flow devices for culturing biological material each comprising a cultivation chamber being dimensioned to retain a biological material and having an inlet and an outlet to allow flow of a cultivation medium through the cultivation chamber. The present invention also refers to... Agent: Agency For Science, Technology And Research

20110269227 - Peptide having bindability with adiponectin, analysis method utilizing same peptide, and analysis device utilizing same peptide: Developed is an adiponectin-recognition material which is inexpensive and excellent in: productivity; stability of quality and a structure; and convenience. The present invention provides a peptide consisting of not more than 50 amino acids and having bindability with adiponectin.... Agent: Sharp Kabushiki Kaisha

20110269228 - Storage unit for at least one device for identifying animals and/or collecting animal tissue, and corresponding method for identifying or collecting tissue: A storage unit is disclosed for at least one animal identification and/or animal tissue collecting device, capable of storing said at least one identification and/or collecting device. In several embodiments, such a set includes at least one container containing a specific agent designed to be applied at least partially to... Agent: Allflex Europe

20110269230 - Methods and compositions for maintaining genomic stability in cultured stem cells: The present application relates to methods and compositions for the generation of therapeutic cells having reduced incidence of karyotypic abnormalities. In several embodiments cardiac stem cells are cultured in an antioxidant-supplemented media that reduces levels of reactive oxygen species, but does not down regulate DNA repair mechanisms. In several embodiments,... Agent: Cedars-sinai Medical Center

20110269229 - Methods of inhibiting viral replication: The instant invention provides methods for the treatment and prevention of viral infection, e.g., HIV infection, based on the discovery that viral replication utilizes the ubiquitination pathway of the host cell to replicate. Specifically, the invention provides methods for the treatment and prevention of viral infection, e.g., HIV infection, by... Agent: The Johns Hopkins University

20110269231 - Proteoglycan-binding peptides that modulate stem cell behavior: Biomaterials presenting synthetic peptides and methods of preparing biomaterials are disclosed. More particularly, the disclosure is directed to biomaterials including a substrate including a synthetic peptide thereon, wherein the synthetic peptide is selected from synthetic proteoglycan-binding peptides, synthetic glycosaminoglycan-binding peptides, and combinations thereof. The present disclosure is further directed to... Agent: Wisconsin Alumni Research Foundation

20110269232 - Method for culturing animal hepatocyte: Provided are a technique for easily forming a spheroid by three-dimensionally culturing hepatocytes, and a technique for forming a spheroid having a higher expression level of a transporter MRP2 playing a role of biliary excretion than that of a conventional method. In order to solve the above-described problems, the present... Agent:

20110269233 - Compositions and methods for regulating cell osmolarity: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing... Agent:

20110269234 - Methods and compositions for increasing nuclease activity: Disclosed herein are methods and compositions for increasing nuclease activity to increase nuclease-mediated genomic modifications.... Agent: Sangamo Biosciences, Inc.

20110269235 - Methods for culturing mammalian taste cells: The invention provides methods of culturing mammalian taste cells, including taste receptor cells. Cells are maintained for a duration of up to three months and longer while maintaining molecular and functional characteristics of mature taste cells. The cells are cultured on coated cell culture vessels and, from first replacement of... Agent: Monell Chemical Senses Center

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