|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology October categorized by USPTO classification 10/11Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 10/27/2011 > 138 patent applications in 76 patent subcategories.
20110262891 - Microinjection apparatus and microinjection method: A microinjection apparatus is designed to introduce the transfecting material into the transductant by inserting a minute injection needle (11) into the transductant and includes a container position adjuster (1), an imaging device (2), a position determiner (3) and a plurality of transporters (4). The container position adjuster adjusts the... Agent: Ntn Corporation
20110262897 - Imaging techniques using a tridentate ligand: The present invention relates to microscopy and, in particular, Time-resolved Emission Imaging Microscopy (TREM). The Invention relates to the use of a transition metal complex having a tridentate ligand in an imaging technique. The transition metal is preferably platinum.... Agent: Science And Technology Facilities Council
20110262892 - Methods for detection or measurement of viruses: A method for treating a virus-containing sample, characterized by treatment of a virus-containing sample with a treatment solution containing (1) an anionic surfactant and (2) an amphoteric surfactant, nonionic surfactant or protein denaturant; a virus assay method using said treating method; a method for treating a virus-containing sample, characterized by... Agent:
20110262895 - Methods for the diagnosis of varicella zoster virus infection: The present invention relates to methods and devices for the rapid assessment of saliva for the presence of varicella zoster virus (VZV) particles. The methods and devices permit rapid, simple and cost-effective diagnosis of primary VZV infection.... Agent:
20110262893 - Separating target analytes using alternating magnetic fields: The invention generally relates to using magnetic particles and alternating magnet fields to separate a target analyte from a sample. In certain embodiments, methods of the invention involve contacting a sample with magnetic particles including first moieties specific for a target analyte, thereby forming target/particle complexes in the sample, flowing... Agent: Nanomr, Inc.
20110262896 - System and method for multi-analyte detection: The present invention provides a system and method for the simultaneous detection of multiple analytes in a sample. The detection system includes a housing that holds a reagent carousel rotatably coupled thereto. Further included in the housing is an incubator carousel rotatably coupled thereto. The housing also includes magnetic material... Agent: Bio-rad Laboratories, Inc
20110262894 - Vaccine against infectious agents having an intracellular phase, composition for the treatment and prevention of hiv infections, antibodies and methods of diagnosis: A vaccine for treating and/or preventing infectious diseases where the infectious agent has at least one intracellular phase in the host during its multiplication cycle, is disclosed. The vaccine comprises at least one cryptic epitope of a cellular element that is carried along by an intracellular infectious agent as it... Agent: Institut National De La Sante Et De La Recherche Medicale (inserm)
20110262902 - Cis-acting diversification activator and method for selective diversification of nucleic acids: The invention relates to identification of a cis-acting diversification activator (DIVAC) that is necessary and sufficient for the activation of diversification in transcription units linked thereto. The invention provides a method for diversification of a target nucleic acid comprising introducing a genetic construct comprising the diversification activator into a recipient... Agent: Heimholz Zentrum Munchen Deutsches Forschungszen- Trum Fur Gesundheit Und Umwelt (gmbh
20110262898 - Compositions, methods, and kits for amplifying nucleic acids: The present teachings are directed to compositions, methods, and kits for amplifying target nucleic acids while reducing non-specific fluorescence and undesired amplification products, sometimes referred to as secondary amplification products or spurious side-products. The enzyme inhibitors disclosed herein comprise a nucleotide sequence and at least one quencher. Complexes comprising an... Agent: Applied Biosystems, LLC
20110262904 - Fluorescent dyes,methods of synthesis and applications thereof: The present invention provides a category of cyanine dyes having the following general structural Formula I, wherein X is defined as C(CH3)2, O, S or Se; m is an integer from 1 to 18, R1 and R2 are each independently chosen from H, C1-18alkyl, OR7, C1-6alkyl-OR7 or halogen; R3 is... Agent:
20110262899 - Fluorescent labeling of transfer rna and study of protein synthesis: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or... Agent: The Trustees Of The University Of Pennsylvania
20110262905 - Kit for the optimisation of protein synthesis/secretion: The invention relates to a kit to be used for the identification of a secretion cassette, which in eukaryotic cells gives rise to a higher level of synthesis/secretion of a protein of interest, the coding sequence of which being flanked by the first and the second set of genetic elements,... Agent: Uni'targeting Research As
20110262900 - Male reproductive health panel and uses thereof: A male reproductive health screening panel is disclosed. In some embodiments, the method comprises screening human sperm using a sperm DNA accelerated decondensation (SDAD) Test, and/or a Sperm DNA decondensation (SDD) assay, in combination with an assessment of the sperm DNA fragmentation index (DFI) of the sperm sample of interest.... Agent:
20110262906 - Microfluidic multiplexed cellular and molecular analysis device and method: A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction... Agent: Dublin City University
20110262903 - Modified proteins and methods of making and using same: Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for... Agent: Life Technologies Corporation
20110262907 - Procecure for preparing a processed virtual analysis image: This method includes the following steps: carrying out a processing of the specimen so as to make it possible to differentiate the pathological cells from the healthy cells of the specimen; and performing an acquisition of images of the specimen disposed on an analysis plate so as to obtain a... Agent: Novacyt
20110262901 - Susceptibility variants for peripheral arterial disease and abdominal aortic aneurysm: The present invention discloses certain genetic variants as susceptibility variants for peripheral arterial disease (PAD) and abdominal aortic aneurysm (AAA). The invention relates to risk management using such variants. The invention further relates to kits for use in risk assessment of PAD and AAA.... Agent: Decode Genetics Ehf.
20110262911 - Correcting an assay image of an array of signals generated from a multiplexed hybridization-mediated assay: Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is... Agent: Bioarray Solutions, Ltd.
20110262909 - Genetic markers for horned and polled cattle and related methods: Embodiments of the present invention provide methods for improving desirable animal traits including the horned/polled phenotype in bovine animals. Also provided are methods for determining a dairy animal's genotype with respect to multiple markers associated with polled, fitness and/or productivity traits. The invention also provides methods for selecting or allocating... Agent: Pfizer
20110262918 - Improved nanoparticulate compositions of poorly soluble compounds: The present invention is related to a method for the quantification of one or more target ribonucleic acids in a sample comprising the steps of, (i) providing a sample comprising said one or more target ribonucleic acids, (ii) contacting said sample with a ribonucleic acid specific fluorescence dye under conditions... Agent: Qiagen Gmbh
20110262908 - Isolation of protein factors that associate directly or indirectly with nucleic acids: Methods for isolating polypeptides and polypeptide complexes that are associated with a target nucleic acid sequence are provided. The methods comprise the steps of obtaining a sample that comprises a target nucleic acid sequence and one or more polypeptides or proteins associated with that target nucleic acid sequence; contacting the... Agent: The General Hospital Corporation
20110262910 - Marker for colon cancer and method for detecting colon cancer: In embodiments the expression or methylation of the TBX5 gene is used as a marker for the presence and prognosis of colon cancer. In further embodiments methods for detecting colon cancer are disclosed as are methods for inhibiting the growth of colon cancer cells.... Agent: The Chinese University Of Hong Kong
20110262913 - Marking: The invention provides a marking system, markers and methods of use of such marking systems and markers which enable unique marking of articles and subsequent detection of that marking. In particular the invention provides a marking system, the marking system comprising a plurality of different DNA fragment types, each of... Agent: Forensic Science Service Ltd.
20110262912 - Method for measuring dna methylation: The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on.... Agent: Sumitomo Chemical Company, Limited
20110262915 - Method for predicting the athletic performance potential of a subject: A method for predicting the athletic performance potential of a subject comprising the step of assaying a biological sample from a subject for a genetic variant in linkage disequilibrium with MSTN-66493737 (T/C) SNP. The invention also provides an assay for determining the athletic performance potential of a subject.... Agent:
20110262919 - Method for pretreating specimen and method for assaying biological substance: On magnetic particles serving as a first support, an antibody against a nonspecific reaction factor is immobilized. These magnetic particles are mixed with a specimen and suspended therein. After suspending, the suspension is sucked up into a pipette chip and a magnet comes close to the pipette chip. While remotely... Agent:
20110262914 - Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases: Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or... Agent: Xdx, Inc.
20110262917 - Modified nucleotides: Modified nucleotides, and methods to modify nucleotides with a moiety or label, such as biotin, that permits their detection and results in a modified nucleotide, and methods of use of the modified nucleotide in quantitative and qualitative assays.... Agent: Pierce Biotechnology, Inc.
20110262916 - Non-invasive fetal rhd genotyping from maternal whole blood: The present invention discloses methods of determining the RhD genotype of subject. In particular, the invention provides a non-invasive method of determining fetal RhD genotype from a maternal biological sample containing fetal cells. The invention also provides novel probes and primers useful in the described methods. Kits and mixtures comprising... Agent:
20110262922 - Aptamer sandwich assays: The present invention provides methods for identifying the plurality of aptamers that bind to different sites of a target molecule and methods for using the same, for example, in sandwich assays. In particular, the plurality of aptamers binding to different sites of the target molecules is identified from a library... Agent: Postech Academy-industry Foundation
20110262920 - Methods for predicting survival in cancer patients: A method for survival prediction in cancer patients is provided. In one embodiment, the survival prediction is determined by the presence or absence of KRAS gene region deletion and/or loss of Chromosome 12 (Ch. 12) in cancer tumor tissue. In another embodiment, the presence or absence of KRAS gene region... Agent:
20110262924 - Molecular assay for diagnosis of hiv tropism: The invention is directed to compositions, methods and kits for HIV subtypes in a test sample, wherein target sequence are amplified. The amplified target sequences are then analyzed by any number of mass spectrometric techniques, which data are queried against a database of base composition signatures of HIV subtypes.... Agent: Abbott Laboratories
20110262921 - Test for the detection of bladder cancer: A diagnostic or prognostic method for detecting malignant and premalignant bladder cancer comprising the identification and quantification of an expression level of identified gene products in the body fluids of a patient and subsequently comparing the expression level of the patient to the expression level found in subjects that do... Agent:
20110262927 - Analyzing bacteria without culturing: The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most 24 hrs of culturing) or no culturing of the pathogen. In certain embodiments, the invention provides methods for identifying a... Agent: Nanomr, Inc.
20110262926 - Extracting low concentrations of bacteria from a sample: The invention generally relates to conducting an assay on a sample that isolates a bacterium from the sample, in which the assay isolates as low as about 1 CFU/ml of bacteria in the sample.... Agent: Nanomr, Inc.
20110262925 - Methods for isolating a target analyte from a heterogeneous sample: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.... Agent: Nanomr, Inc.
20110262928 - Disease markers and uses thereof: The present invention encompasses miRNA profiles and type-I IFN/IFNα-induced PD marker profiles in inflammatory or autoimmune disorders, such as myositis. The profiles may also be used in, for example, methods of treating patients, methods of monitoring disease progression of patients, and in diagnosing or providing a prognosis to patients having... Agent: Medimmune LLC
20110262929 - Anti-hs6st2 antibodies and uses thereof: The present invention provides antibodies that bind to HS6ST2 proteins, pharmaceutical compositions comprising the antibodies as active ingredients, methods for diagnosing cancer using the antibodies, HS6ST2 proteins conjugated to cytotoxic agents and pharmaceutical compositions comprising the HS6ST2 proteins as active ingredients.... Agent: Forerunner Pharma Research Co., Ltd.
20110262930 - Screening and treatment methods using igs5 enzymes of the metalloprotease family: Polypeptides which are related to the neprilysin enzyme family and have zinc metalloprotease activities and are referred to as IGS5, polynucleotides encoding such polypeptides, vectors containing such polynucleotides, host cells containing such vectors, processes for producing such polypeptides and/or polynucleotides, screening methods for identifying compounds which stimulate or inhibit IGS5... Agent: Abbott Healthcare Products B.v.
20110262932 - Compositions: The invention generally relates to compositions that include magnetic particles bound to pathogens in a body fluid.... Agent: Nanomr, Inc.
20110262933 - Compositions and method for isolating mid-log phase bacteria: The invention generally relates to compositions and methods for isolating mid-log phase bacteria. In certain embodiments, the invention provides a magnetic particle conjugated to an antibody that includes an epitope specific for mid-log phase bacteria.... Agent: Nanomr, Inc.
20110262931 - Mast cell carboxypeptidase as a marker for anaphylaxis and mastocytosis: The present invention relates to use of mast cell carboxypeptidase as a marker for anaphylaxis or mastocytosis in serum, plasma or saliva samples. Detection of elevated mast cell caroboxypeptidase in for example serum samples is proposed for reducing false negatives in relation to diagnosis of anaphylaxis and various categories of... Agent:
20110262935 - Method for detecting a prion infection: The invention relates to an in vitro method for detecting and/or titrating an unconventional transmissible agent (UTA) or a protein of pathological conformation which is a marker for the infectivity of the UTA, in a sample, comprising a step of concentrating the sample before and after digestion with a protease.... Agent: Lgb-biotecnologies
20110262934 - Method for early diagnosis of alzheimer's disease using phototransistor: Disclosed is a method for the early diagnosis of Alzheimer's disease. In the method, cells in which a biomarker characteristic of Alzheimer's disease, preferably beta-amyloid, is labeled with magnetic beads are selectively located in the channel region of a phototransistor, and a difference in photocurrent between normal cells and the... Agent: Electronics And Telecommunications Research Institute
20110262938 - Determination of the amount of hlhb core fragment in a sample from a subject and uses thereof: The present invention provides a method for predicting the likely timing of the onset of menopause for a perimenopausal female subject by determining the amount of hLHβcf in a sample from the subject comprising the steps of: (a) contacting a sample from the subject with an antibody which specifically binds... Agent: The Trustees Of Columbia University In The City Of New York
20110262936 - Method of determining a concentration of analytes of interest in a sample: A method of determining a concentration of analytes of interest in a sample reaction mixture is disclosed. The method can include measuring intensities of the polarized fluorescence of at least one comparative reaction mixture containing different, known amounts of the analytes of interest, and measuring the intensities of the polarized... Agent: Aokin Ag
20110262939 - Methods and assays for classifying foodstuff and/or beverage and/or diet and/or nutrition regimen and/or medicament in view of an effect on the cardiovascular system: Subject of the present invention is an in vitro-method for classifying a foodstuff and/or beverage and/or diet and/or nutrition regimen and/or medicament in view of an effect on the cardiovascular system of a subject, comprising determining the relative level of one or more cardiovascular markers.... Agent: B.r.a.h.m.s Gmbh
20110262940 - Capillary for immunoassay, and capillary immunoassay method using same: A capillary for an immunoassay is provided which comprises an insoluble layer of an oxidase formed on an inner wall surface of said capillary, said oxidase being conjugated to a first antibody, and a layer of a hydrophilic polymer formed on said insoluble layer, said hydrophilic polymer layer containing a... Agent:
20110262941 - Predicting mortality and detecting severe disease: Measurement of circulating ST2 and/or IL-33 concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, and the detection of severe disease.... Agent:
20110262942 - Oxidizable species as an internal reference in control solutions for biosensors: Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound... Agent: Bayer Healthcare LLC
20110262944 - Construction and crystallization of expression system for rna polymerase pb1-pb2 protein derived from influenza virus: The present invention provides a complex comprising a polypeptide consisting of an amino acid sequence at positions 678-757 of the RNA polymerase PB1 subunit in influenza A/Puerto Rico/8/34 H1N1 and a polypeptide consisting of an amino acid sequence at positions 1-37 of RNA polymerase PB2 subunit in influenza A/Puerto Rico/8/34... Agent: University Of Tsukuba
20110262943 - Reagent kit for measuring freshness: A reagent kit for measuring freshness, which can be stored at a relatively high temperature with high storage stability, is obtained by lyophilizing reagent solutions each containing a plurality of enzymes and an enzyme protecting agent. The reagent kit includes a first reagent and a second reagent. The first reagent... Agent: Tokyo University Of Marine Science And Technology
20110262945 - Glycoprotein production method and screening method: A method for producing a glycoprotein, which is uniform in terms of functions derived from a sugar chain (e.g., a blood half-life) and physiological activities, i.e., a glycoprotein, which is uniform in terms of the amino acid sequence, the sugar chain structure and the higher-order structure; specifically, a method for... Agent: Otsuka Chemical Co., Ltd.
20110262947 - Isotopically-labeled proteome standards: The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for... Agent: Life Technologies Corporation
20110262946 - Monitoring a dynamic system by liquid chromatography-mass spectrometry: The present invention provides a method for monitoring of profile changes of components in a dynamic system such as a cell-free in vitro protein synthesis system by using liquid chromatography (LC) combined with mass spectrometry (MS). In an additional aspect, this invention provides a method for enhancing the yield and/or... Agent: Sutro Biopharma, Inc.
20110262948 - Methods of quantifying methotrexate metabolites: The present invention provides a method for efficiently converting methotrexate polyglutamates to methotrexate in a cellular extract by contacting the cellular extract with gamma glutamyl hydrolase under conditions suitable for efficient conversion of methotrexate polyglutamates to methotrexate.... Agent: Exagen Diagnostics, Inc.
20110262949 - Genetic incorporation of 3-aminotyrosine into reductases: This invention provides reductase proteins that comprise NH2Y unnatural amino acid residues, systems of orthogonal elements for incorporating NH2Y into reductases and methods of using NH2Y amino acid residues in reductases as molecular probes for probing reductases function, structure and activity.... Agent: The Scipps Research Institute And Massachusetts Institute Of Technology
20110262950 - Redox mediators: The present invention relates to ruthenium and osmium complexes of Formula [M(A)w(B)xCy]m(Xz)n, per se and the use of ruthenium and osmium complexes of Formula I as redox mediators in electrochemical biosensors.... Agent: F. Hoffmann-la Roche Ag
20110262956 - Co-culture compositions and methods: Co-culture compositions and methods are described for identifying agents that modulate a cellular phenotype, particularly of neurons or pancreatic beta cells are provided herein, where the methods include co-culturing differentiated cells, wherein at least one of the cell-types are derived from human induced pluripotent stem cells from a subject having... Agent:
20110262951 - Collection device and material: Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers.... Agent:
20110262952 - Collection device and material: Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends.... Agent:
20110262957 - Compositions for the detection of intracellular bacterial targets and other intracellular micororganism targets: Presented herein are solid supports on or in which a composition comprising a lysis reagent and an intracellular microorganism target detection reagent (e.g., an intracellular bacterial target detection reagent) is present in added form. Presented herein are also methods for detecting the presence of an intracellular microorganism target (e.g., an... Agent:
20110262958 - Device for examining myocardial toxicity, chip for examining myocardial toxicity and method for examining myocardial toxicity: [Means for Solving the Problem] A cell population as a pulsating pacemaker is arranged on a transparent substrate, and then myocardial pulsating cells are arranged while being spaced apart appropriately. An appropriate number of fibroblast cells are arranged with/connected to the myocardial pulsating cells to form a cell network. Each... Agent: Mitsubishi Chemical Medience Corporation
20110262959 - Method for evaluation of differentiation ability of stem cell: e
20110262955 - Methods for determining sodium-proton-exchanger ligand efficiency: The present invention relates to methods for determining the efficiency of an ion channel ligand comprising (a) contacting a cell expressing the ion channel with (i) plasma of an animal and (ii) the ion channel ligand and (b) determining the effect of the ion channel ligand on the cell.... Agent: Sanofi-aventis
20110262953 - Phosphate limited inducible promoter and a bacillus expression system: An evolvable production strain of B. subtilis exhibiting continuous or high level expression during protein evolution is described. An evolved Bacillus subtilis pstS promoter facilitates screening and production of secreted proteins.... Agent: Danisco US Inc.
20110262954 - Shuttle vector based transformation system for pyrococcus furiosus: The present invention relates to vectors for transforming archaea and to transformed archaea, and in particular to shuttle vector systems for transformation of members of the genus Pyrococcus.... Agent: Universitat Regensburg
20110262960 - Mycobacteria culture medium and method including mycobacteria of mycobacterium tuberculosis complex: The present invention relates to a novel mycobacteria culture medium, particularly for mycobacteria of the Mycobacterium tuberculosis complex, that significantly reduces the culture isolation time and thus the time for diagnosing the mycobacteria, particularly those for tuberculosis. A culture medium according to the invention contains defibrinated blood, lecithin, and decomplemented... Agent: Universite De La Mediterranee (aix-marseille Ii)
20110262961 - Diagnosis, prevention and treatment of disorders characterized by undesirable cell proliferation: The present invention relates to compositions and methods for the reduction of atherosclerotic plaques and the decrease in the level of total serum cholesterol, triglycerides, serum LDL cholesterol, and serum HDL cholesterol. The present invention also relates to methods for the diagnosis, prevention and treatment of atherosclerosis and mycoplasma associated... Agent:
20110262963 - Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues: Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is... Agent:
20110262962 - Method for producing peptides: The present invention provides a method for producing a peptide, comprising culturing a transformant introduced with an expression vector to prepare a culture, and mixing the culture with a carboxy component and an amine component to form the peptide. The expression vector comprises a polynucleotide encoding a protein: (A) having... Agent: Ajinomoto Co., Inc.
20110262965 - Cell culture medium comprising small peptides: Cell culture media, concentrated media and feeds, methods of manufacturing cell culture media and feeds, and methods of culturing cells are provided. One or more small peptides, including dipeptides are added to the cell culture media to provide improved stability and improved conditions for culturing cells.... Agent: Life Technologies Corporation
20110262964 - Reagentless fluorescent biosensors comprising a designed ankyrin repeat protein module, rational design methods to create reagentless fluorescent biosensors and methods of their use: The present invention relates to reagentless fluorescent biosensors which comprise at least one ankyrin repeat and a fluorophore and are specific for at least one target; the method for preparing such reagentless fluorescent biosensors comprises the following steps: (a) identifying the residues (R1) of the paratope of the biosensor by... Agent:
20110262966 - Dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants: Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient... Agent: Arizona Board Of Regents For And On Behalf Of Arizona State University
20110262968 - Antibodies that bind to psca proteins for diagnosis of cancer: Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The... Agent: Agensys, Inc.
20110262967 - Use of hsa-producing cells: The present invention refers to the area of cell culture technology and relates to methods for multiplying/cloning cells, preferably cell lines, which are important to the production of biopharmaceuticals. The invention further relates to methods for manufacturing proteins and to the use of cells extracted and multiplied through single cell... Agent: Boehringer Ingelheim Pharma Gmbh & Co. Kg
20110262969 - Method for producing optically active, cyclic depsipeptides comprising lactic acid and phenyl lactic and having 24 ring atoms, using fungus strains of rosellinia type, and further species of xylariaceae: The present invention relates to a process for the preparation of lactic- and phenyllactic-acid-containing, optically active, cyclic depsipeptides with 24 ring atoms by means of fungal strains of the genus Rosellinia and further Xylariaceae isolated not only from fruiting bodies of Rosellinia spp. and Xylariaceae growing on dead timber and... Agent:
20110262970 - Enzymatic hydrolysis of pretreated lignocellulose-containing material with cationic polysaccharides: A method for producing a fermentation product from a lignocellulose-containing material comprises pre-treating the lignocellulose-containing material; introducing a cationic polysaccharide to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to an effective amount of a first hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation product.... Agent: Novozymes North America, Inc.
20110262971 - Genetically modified e. coli strains for producing erythromycin: Genetically modified E. coli strains capable of producing erythromycins, particularly erythromycin A.... Agent: Tufts University
20110262972 - Chondroitin synthase, method for producing the same and method for producing saccharide chain-extended chondroitin: A vector of the present invention has DNA encoding a protein or a product having the same effect as the protein, the protein containing an amino acid sequence from amino acid numbers 47 to 802 in SEQ. ID. NO:2. Expression of the DNA gives human chondroitin synthase. By using human... Agent: Otsuka Chemical Co., Ltd
20110262973 - Methods and compositions for dna manipulation: single-stranded extension having a desired length and sequence composition. Methods for forming single-stranded extensions include: the use of a cassette containing at least one nicking site and at least one restriction site at a predetermined distance from each other and in a predetermined orientation; or primer-dependent amplification which introduces into... Agent: New England Biolabs, Inc.
20110262974 - Novel enzymes for use in enzymatic bleaching of food products: The present invention relates to novel polypeptides according to caroase 01-05 or any functional equivalents of any of them, suitable for use in a method for preparing a food products having increased whiteness, the use of the enzyme to increase whiteness of at least part of a food product, a... Agent: DsmIPAssets B.v.
20110262975 - Engineered co2 fixing microorganisms producing carbon-based products of interest: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the... Agent: C/o Joule Unlimited, Inc.
20110262976 - Production of r-a-lipoic acid by fermentation using genetically engineered microorganisms: This application provides systems and methods for the production of R-α-lipoic acid. Lipoic acid synthesis genes may be expressed in an acid-tolerant microorganism, such as Gluconobacter oxydans. The lipoic acid synthesis proteins may include LipA and SufE. The genetically engineered strain may be cultured under suitable culture conditions, such as... Agent: Indigene Pharmaceuticals, Inc.
20110262977 - Process for production of optically active amine derivative: i
20110262978 - Expression vector for pseudonocardia autotrophica: An expression vector capable of expressing a foreign gene in Pseudonocardia autotrophica; a transformant of Pseudonocardia autotrophica produced by using the expression vector; a method for producing a protein by using the transformant; a method for producing an active form of vitamin D3 from vitamin D3, which comprises highly expressing... Agent: Mercian Corporation
20110262979 - Novel composition of matter for use in producing co-enzyme q10 and a novel method for producing co-enzyme q10: The present invention provides materials and methods for the growth of microorganisms for the production of organic chemicals, for example, coenzyme Q10.... Agent:
20110262981 - Carotenoid fermentation method: The present invention provides a method for producing a carotenoid, which comprises culturing a carotenoid-producing bacterium in an amino acid-supplemented medium, and collecting the carotenoid from the resulting cultured product, wherein the amino acid is at least one selected, from the group consisting of glutamic acid, aspartic acid, glutamine, asparagine,... Agent: Jx Nippon Oil & Energy Corporation
20110262980 - Micro-organisms for the production of acetol obtained by a combination of evolution and rational design: The present invention also concerns the evolved strain such as obtained, that may be furthermore genetically modified in order to optimize the conversion of a simple carbon source into acetol without by-products and with the best possible yield.... Agent:
20110262982 - Acetolactate synthase having 2-ketoisovalerate decarboxylase activity and uses thereof: Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol, and 2-phenylethanol from a suitable substrate and a recombinant acetolactate synthase having both synthase and decarboxylase activity.... Agent: The Regents Of The University Of California
20110262983 - Metabolically engineered yeasts for the production of ethanol and other products from xylose and cellobiose: The present invention provides yeast cells that produce high concentrations of ethanol, culture media and bioreactors comprising the yeast cells, and methods for making and using the yeast cells in efficiently producing ethanol.... Agent: The United States Of America As Represented By The Secretary Of Agriculture
20110262984 - Method for producing ethanol and co-products from cellulosic biomass: The present invention generally relates to processes for production of ethanol from cellulosic biomass. The present invention also relates to production of various co-products of preparation of ethanol from cellulosic biomass. The present invention further relates to improvements in one or more aspects of preparation of ethanol from cellulosic biomass... Agent: Abengoa Bioenergy New Technologies, Inc.
20110262985 - Processing biomass: Methods are provided for changing a molecular structure of a biomass feedstock. The methods include a screw extrusion process.... Agent: Xyleco, Inc.
20110262986 - Biological solar panel devices, arrays, methods and systems for the collection of volatile organic molecules: Provided herein are devices, arrays, methods, systems, and other subject matter comprising a biological solar panel device comprising: (a) a layer comprising a material is transparent or translucent to light; (b) a photosynthetic layer comprising a material that uses carbon dioxide and water in the presence of sunlight to release... Agent:
20110262987 - Solubilization of carbonaceous materials and conversion to hydrocarbons and other useful products: Methods of producing useful products, such as hydrocarbons and other molecules that are useful as fuels, from carbonaceous materials, are disclosed. Such methods include obtaining a carbonaceous material, such as coal, from a deposit and treating the carbonaceous material with one or more chemicals, including acetic acid, salts of acetic... Agent:
20110262988 - Methods and compositions for enhanced bacterial hydrolysis of cellulosic feedstocks: The present invention provides compositions comprising a cellulolytic bacterium and an isolated BETA-glucosidase enzyme or comprising cellulolytic bacterium that expresses a secreted recombinant BETA-glucosidase enzyme, and methods of using same for hydrolysis of cellulose and cellulosic feedstocks.... Agent: Designer Energy Ltd.
20110262990 - Acoustic device and methods thereof for separation and concentration: The invention provides a settling device comprising an acoustic wave generator and an inclined settling chamber. The angle θ between the acoustic wave direction and the inclined settling chamber is greater than 0 and less than 90°. The invention also provides a concentration method and a separation method using the... Agent:
20110262989 - Isolating a target analyte from a body fluid: The invention generally relates to using magnetic particles and magnets to isolate a target analyte from a body fluid sample. In certain embodiments, methods of the invention involve introducing magnetic particles including a target-specific binding moiety to a body fluid sample in order to create a mixture, incubating the mixture... Agent: Nanomr, Inc.
20110262991 - Living copolymer-protein/peptide hybrids for biomedical applications: Water soluble polymers having formula I: Y-(L1)ni-(C(O))n2—(R1)n3—R2 are claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.... Agent: The Research Foundation Of The City University Of New York
20110262993 - Method for preparing a cellular carbon monolith comprising a hierarchised porous network: A carbon or ceramic monolithic materials with an M2 (macroporous/microporous) hierarchised porous structure is provided as well as method for preparing said materials using a macro/meso/microporous silica cavity. Such materials may be used, in particular for the production of hydrogen purifiers, supercapacitors or electrodes, or else for carrying out catalysed... Agent:
20110262992 - Method for stabilizing labeled antibody: The present invention relates to a method for stabilizing a labeled antibody in a solution, in which the labeled antibody is stabilized by allowing the labeled antibody to be present together with at least one of amino acid and a derivative thereof in the solution.... Agent: Arkray, Inc.
20110262994 - Novel reagents and method for conjugating biological molecules: A compound of the general formula X-[Q-W—(CH═CH)n—(CH2)2-L]m (I) in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing group; n represents 0 or an integer of from 1 to 4; L represents a leaving group; and m represent an integer of from 1 to 8.... Agent: Polytherics Limited
20110262995 - Grg32: a novel epsp synthase gene conferring herbicide resistance: Compositions and methods for conferring herbicide resistance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include nucleic acid molecules encoding herbicide resistance or tolerance polypeptides, vectors comprising those nucleic acid molecules, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in... Agent:
20110262996 - Methods and materials for degrading pyrethroid: Methods and compositions are provided for enzymatic detoxification of pyrethroid such as permethrin. The methods involve application of compositions of organophosphorus hydrolase OPH to surfaces or substances contaminated with pyrethroid such as permethrin.... Agent: Danisco US Inc.
20110262997 - Production of cellulase: The invention relates to a process of producing cellulase in a host cell, comprising cultivating said host cell capable of producing cellulase under conditions conducive for production of cellulase, wherein pre-treated ligno-cellulosic material is added to induce cellulase production. The invention also relates to use of pre-treated ligno-cellulosic material as... Agent: Novozymes North America, Inc.
20110262998 - Process for preparing inclusion body-forming protein: A process for preparing an inclusion body-forming protein is provided. A nucleic acid fragment consisting of a nucleotide sequence coding for a modified alkaline phosphatase signal peptide (modified APSP) where leucine at the 13th position in the amino acid sequence shown in SEQ ID NO: 1 is substituted with proline... Agent: The Chemo-sero-therapeutic Research Institute
20110262999 - Compositions and methods comprising protease variants: The present invention provides protease variants, compositions comprising protease variants, and methods of using such protease variants and compositions.... Agent: Danisco US Inc.
20110263000 - A thrombin-like enzyme of agkistrodon acutus: A thrombin-like enzyme isolated from Agkistrodon acutus venom, comprising an alpha subunit having the sequence of SEQ ID No. 1 and a beta subunit having the sequence of SEQ ID No. 2, which are linked by seven disulfide bonds, is provided. The hemocoagulase of Agkistrodon acutus in the present invention... Agent:
20110263001 - Compositions and methods for engineering cells: The disclosure relates generally to genetic manipulation of stem and primary cells and to reprogramming of somatic cells, more specifically, human cells. In particular, compositions and methods are disclosed for the generation and maintenance of such engineered cells.... Agent: Life Technologies Corporation
20110263002 - Compositions and methods for continuous harvesting of suspension growth cultures: Embodiments herein concern compositions, methods and uses for harvesting suspension cultures or decontaminating waters. In certain embodiments, suspension microorganism cultures can comprise algal cultures. In some embodiments, harvesting suspension cultures may include using a composition capable of interacting with the culture in order to separate the culture from a liquid... Agent:
20110263003 - Microbacterial peptide deformylase: The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from Mycobacterium tuberculosis. The use of this Antisense-oligonucleotide on mycobacterial culture inhibits the production of the peptide deformylase enzyme by hybridizing within the region, which is found to be responsible for... Agent: Council Of Scientific And Industrial Research
20110263004 - Method of treating biomass: Method of treating a biomass containing a fibrous structure and polysaccharides. According to the method the biomass is subjected to extractive treatment at which it is heated in aqueous phase at an absolute pressure of over 0.6 MPa and a temperature of at least 160° C. for separating polysaccharides from... Agent:
20110263005 - Pipette tip for electroporation device: Provided herein is a pipette tip (600) for electroporation including an outer surface, a void (611) located within the outer surface, and a conductor (622) located at least partially on or within the outer surface, in electrical communication with at least a portion of the outer surface and the void.... Agent: Life Technologies Corporation
20110263007 - Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed: A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction. Applications for the described device and kit are found in the field of medical diagnostics, particularly immunology.... Agent: Universite Libre De Bruxelles
20110263006 - Integrated test strip container with retaining insert: A blood glucose meter for providing easy access to test strips and measuring blood glucose, a disposable and removable cartridge for providing easy access to test strips, and methods of manufacturing and utilization thereof are disclosed. The blood glucose meter for providing easy access to test strips and measuring blood... Agent: Roche Diagnostics Operations, Inc.
20110263008 - Cell culture real-time observation system: The present invention discloses a cell culture realtime observation system comprising a plate, a culture well, an image capture device, at least one container, an evaporation device, a first micro channel, a second micro channel and a transmission unit. The culture well is disposed on the plate, and the image... Agent: National Changhua University Of Education
20110263009 - Method for the filtration of a bioreactor liquid from a bioreactor; cross-flow membrane module, and bioreactor membrane system: The invention provides a method for the filtration of a bioreactor liquid (10) from a bioreactor (1) with a cross-flow membrane module (20) comprising one or more membranes (40). The method comprises feeding part of the bioreactor liquid (10) to a liquid inlet (21) of the cross-flow membrane module (20),... Agent: Paques Bio Systems B.v.
20110263010 - Incubator device and method: The invention provides an incubation device, comprising an incubator chamber (12), a specimen carrier (15), which is designed to accommodate a specimen (14) and position it in the interior of the incubator chamber (12) at a specimen position (P), a heating arrangement (38, 40) with at least one heating element... Agent:
20110263011 - Antifouling coating composition comprising functionalized nanoparticles: Method for providing a substrate with an anti-biofouling coating the method comprising: a. obtaining a coating composition comprising nanoparticles being grafted with reactive groups and hydrophilic polymer chains and a solvent; b. applying the coating composition to the substrate; and c. optionally curing the coating composition herein the surface tension... Agent:
20110263012 - Screening and therapeutic method for nsclc targeting cdca1-kntc2 complex: The present invention is based on the observation that the co-activation of CDCA1 and KNTC2, and their cognate interactions, play significant roles in lung-cancer progression and that methods of inhibiting the complex can be used to treat non-small-cell lung cancer.... Agent: Oncotherapy Science, Inc.
20110263013 - Compositions and methods for growing embryonic stem cells: Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing human umbilical cord blood derived stem cells or secreted proteins obtained from the culture medium of human umbilical cord blood derived stem cells.... Agent:
20110263014 - Cleavage of nanog by caspases mediates the differentiation of embryonic stem cells: The present invention is based on the discovery that a caspase specifically cleaves the transcription factor, Nanog, leading to the initiation of cellular differentiation of embryonic stem (ES) cells. The present invention includes a method of inhibiting the cleavage of Nanog, thereby maintaining the pluripotency of an ES cell or... Agent: Baylor College Of Medicine
20110263015 - Compositions and methods for generation of pluripotent stem cells: The present invention describes the use of pre-trans-splicing molecules (PTMs) to reprogram human normal and diseased somatic cells into pluripotent stem cells using spliceosome-mediated RNA trans-splicing. More specifically, the present invention describes the use of the SMaRT™ technology to repair or reprogram the newly induced diseased pluripotent stem cells.... Agent: Virxsys Corporation
20110263016 - Expansion of embryonic stem cells: The present invention addresses the problem of expanding human embryonic stem cell (hESC) and induced pluripotent stem cell (iPSC) populations to clinically relevant numbers while maintaining pluripotency. In particular, the use of macrolide antibiotics and inhibitors of Rho and Rho-associated kinases is described.... Agent:
20110263018 - Core-shell structured delivery system for growth factors, a preparation method thereof, and use thereof for the differentiation or proliferation of cells: The present invention relates to a method of preparing a delivery system capable of loading bioactive growth factors that are essential for the differentiation and proliferation of cells and is characterized as loading at least two types of components comprising growth factors in a single carrier, whereby the release of... Agent: Korea Institute Of Science And Technology
20110263017 - Technique for regulating regenration of tissue or faulty or abnormal part in organ using nell-1: The object aims to form and maintain a cell, a tissue or an organ induced by differentiation. Disclosed is a composition for inducing the differentiation of a cell capable of being differentiated in a given direction to thereby produce a cell, a tissue or an organ through the further induction... Agent: Showa University
20110263019 - Method of reseeding adherent cells grown in a hollow fiber bioreactor system: This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.... Agent: Caridianbct, Inc.
20110263020 - Membrane for cell expansion: A membrane which can be used for cultivating cells, in particular adherent cells. The membrane permits the adhesion and proliferation of the cells based on its specific composition comprising polyurethane. The resulting surface characteristics further permit the membrane to be used without any pre-treatment with surface modifying substances. A method... Agent: Gambro Lundia Ab
20110263021 - Method and device for industrial biolayer cultivation: A compact, high-yield, bio-reactor for use as small, medium and large-scale production unit for therapeutic proteins, proteins in general and enzymes based on controlled activity of the cells or micro organisms and the production of such as high value antibodies for pharmaceutical and/or bio-diagnostic applications.... Agent: Stobbe Tech A/s
20110263022 - Irradiated membrane for cell expansion: A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in... Agent: Gambro Lundia Ab
20110263023 - Genes for modulating coffee maturation and methods for their use: Disclosed are isolated nucleic acids for modulating coffee maturation. Also disclosed are promoters derived from such genes. Methods for using the nucleic acids for improving quality attributes of coffee are provided. Also provided are methods for assessing the quality of plant-based agricultural products, such as coffee.... Agent: Nestec S.a.
20110263024 - Process of clean cloning: annealing the product of the previous step to a linearized double-stranded acceptor nucleic acid having at a first end thereof a single-stranded overhang complementary to the single-stranded overhang of the first end of the DNA and at a second end thereof a single-stranded overhang complementary to the single-stranded sequence segment... Agent: Icon Genetics Gmbh
20110263025 - Biodegradable polydisulfide amines for gene delivery: Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(N,N′-cystaminebisacrylamide-spermine), poly(N,N′-cystaminebisaciylamide-N,N′-bis(3-aminopropyl)1,3-propanediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(3-amino-propyl)ethylenediamine), poly(N,N′-cystaminebisacrylamide-N,N′-bis(2-aminoethyl)-1,3-propanediamine), and poly(N,N′-cystaminebisacrylamide-triethylenetetramine). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and protected oligoamine monomers, followed by deprotection. Complexes are formed by mixing the poly(disulfide amine)s with a... Agent: University Of Utah Research Foundation
20110263026 - Construction of protein-responsive shrna/rnai control system using rnp motif: An object of the present invention is to provide an RNAi control system using an RNA-protein interaction motif. The present invention provides an shRNA comprising: a guide strand having a sequence complementary to a target sequence; a passenger strand which forms a duplex with the guide strand; and a linker... Agent: Japan Science And Technology Agency
20110263027 - Adeno-associated virus (aav) sequences and isolating novel sequences identified thereby: Adeno-associated virus 7 sequences, vectors containing same, and methods of use are provided.... Agent: The Trustees Of The University Of Pennsylvania
20110263028 - Meganuclease recombination system: The invention relates to a set of genetic constructs which allow the efficient and reproducible introduction of a specific nucleotide sequence at a fixed position in the genome by generating a double strand break at a specific position in the genome using a meganuclease and so stimulating a homologous recombination... Agent: Cellectis10/20/2011 > 107 patent applications in 63 patent subcategories.
20110256522 - Arginine-containing compositions and methods for treating red blood cells: Blood storage and/or rejuvenating compositions that include D-ribose and an arginine (e.g. L-arginine, D-arginine, or a combination thereof) are disclosed herein. Such compositions can be useful in methods for treating (e.g., storing and/or rejuvenating) red blood cells.... Agent:
20110256523 - Optical flow cytometer and method of investigation: The present invention relates to a flow cytometer (10) for in vitro assaying of human or animal whole blood and to an investigation method using the flow cytometer. Enhanced detection properties are achieved by it relative to the prior art cytometers of the same kind. Here, automated beam positioning is... Agent: Diatron Mi Zrt.
20110256528 - Analyte detection assay: A rapid and sensitive analyte detection assay is based on whispering gallery modes of fluorescently labelled microspheroidal particles. Ligands for the analyte, such as nucleic acids, are anchored to the particles. The fluorescent labels may comprise fluorophores or quantum dots. In the latter case, the particles may comprise melamine formaldehyde.... Agent: Genera Biosystems Limited
20110256525 - Compositions and methods for purifying and crystallizing molecules of interest: A composition-of-matter is provided. The composition comprising at least one antibody binding moiety capable of binding an antibody-labeled target molecule, cell or virus of interest, said at least one antibody binding moiety being attached to at least one coordinating moiety selected capable of directing the composition-of-matter to form a non-covalent... Agent: Affisink Biotechnology Ltd.
20110256526 - Detection of human somatic cell reprogramming: The methods and kits described herein are based, in part, to the discovery phenotype representing a fully-reprogrammed iPS cell and several reprogramming intermediates. The methods and kits described herein permit identification of fully-reprogrammed iPS cells and further permits one of skill in the art to monitor the emergence of iPS... Agent: Children's Medical Center Corporation
20110256527 - Rapid and safe technique for performing pcr amplifications: This invention relates to methods for quick and safe identification of pathogens from biological samples. Iodinated resins may be employed to destroy a pathogen while leaving the pathogen's DNA in a state that can be analyzed. The DNA can then serve as a substrate for PCR analysis. The use of... Agent: Safelife/triosyn Corp.
20110256532 - Analyzer: An object of the present invention relates to providing a nucleic acid analyzer capable of testing a plurality of test items in parallel, and of obtaining high efficiency of specimen processing even if the test item or a measuring object is changed. The present invention relates to an analyzer including... Agent:
20110256529 - Beads for use in reactions for the amplification and/or synthesis of a polynucleotide, and a device and a method for the production thereof: A method is provided of making meltable beads for use in reactions for the amplification and/or synthesis of a polynucleotide, the method comprising (i) Providing one or more reagents for use in a reaction for the amplification and/or synthesis of a polynucleotide and a substance for promoting the formation of... Agent:
20110256531 - Biodetection articles: Articles (610) are provided for the detection of cells in a sample. The articles include a hydrogel (640) comprising a cell extractant. Methods of use are also disclosed.... Agent: 3m Innovative Properties Company
20110256530 - Products and methods for tissue preservation: The present application relates to methods for increasing stability of formalin fixed, optionally paraffin embedded biological material. In one example, DNAse inhibitors and/or RNAse inhibitors are combined with the biological material or formalin at the time of fixation or shortly prior.... Agent: Genvault Corporation
20110256538 - Epigenomic dna modifications for tissue typing, early cancer detection, and disease management: Provided herein is a suitable method for detecting the presence or absence of a cancer in an individual, by determining the level of methylation of the sense strand of a selected regulatory region of a tumor suppressor gene. Also provided herein is a method of detecting the presence or absence... Agent: Philadelphia Health & Education Corporation D/b/a Drexel University College Of Medicine
20110256533 - Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance: Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions and methods of... Agent:
20110256539 - Methods for detecting tumor origin based on muc1, muc2, and ck-17 expression levels: Methods and compositions for detecting tumor origin are disclosed. In certain embodiments, the origin is determined by detecting expression levels of pan-epithelial membrane mucin (MUC1), intestinal-type secretory mucin (MUC2), cytokeratin 17 (CK17), or a combination thereof. Also disclosed are methods for aiding in the determination of an appropriate course of... Agent:
20110256535 - Optimized oligonucleotides and methods of using same for the detection, isolation, amplification, quantification, monitoring, screening and sequencing of clostridium difficile genes encoding toxin b, and/or toxin a and/or binary toxin: Described herein are oligonucleotides useful for detecting, isolating, amplifying, quantitating, monitoring, screening and sequencing the C. Difficile genes encoding toxin B, and/or toxin A, and/or binary toxin, and methods of using the described oligonucleotides.... Agent: Intelligent Medical Devices, Inc.
20110256537 - Optimized oligonucleotides and methods of using same for the screening, detection, isolation, quantitation, monitoring and sequencing of prostate cancer associated viruses and host biomarkers: Described herein are oligonucleotides useful for screening, detecting, isolating, quantitating, monitoring and sequencing of viruses and host biomarkers associated with prostate cancer and methods and kits of using the described oligonucleotides.... Agent: Intelligent Medical Devices, Inc.
20110256534 - Prediction of antiviral therapy response: The application relates to methods for determining whether or not antiviral therapies will be effective. In particular, the present application provides a method using miRNA, e.g. miR-122 or miR-296-5p, for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that... Agent: Novartis Forschungsstiftung, Zweigniederlassung Friedrich Mischer Institute For Biomedical Researc
20110256536 - Two stage nucleic acid amplification using an amplification oligomer: This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a second nucleic acid amplification or assay. Two or more amplification oligomers can... Agent: Panomics, Inc.
20110256541 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent:
20110256542 - Droplet actuator devices, systems, and methods: The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one application, droplet actuators are used to conduct genetic analysis using polymerase chain reaction (PCR) techniques. The invention addresses the need... Agent: Advanced Liquid Logic, Inc.
20110256540 - Unrestricted mutagenesis and cloning methods: The invention relates to methods for amplifying, modifying, mutating and cloning DNA of any size. These methods comprise a series of PCR reactions, which are punctuated by ligation reactions.... Agent:
20110256543 - Use of novel cytokine receptors as biomarkers and therapeutic targets in human cancer: Nucleic acids encoding erythropoietin isoforms are described herein, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.... Agent:
20110256544 - Molecules interacting with casl (mical) polynucleotides, polypeptides, and methods of using the same: The present invention provides MICAL and MICAL-Like polypeptides and polynucleotides. Also provided are methods that for identifying agents that affect axon growth and placement. Furthermore, provided herein are methods for affecting axon growth and placement.... Agent:
20110256545 - Mrna expression-based prognostic gene signature for non-small cell lung cancer: A non-small cell lung cancer postoperative survival prognosticator comprising a detection mechanism consisting of 15-gene, 12-gene, and 16-gene signature and methods of use. Also provided are the identification of various subsets from the 25 prognostic signature genes with potential of operative survival prognosticator for non-small cell lung cancer patients in... Agent:
20110256546 - Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (alk) kinase inhibitors: Compositions and methods for the diagnosis and treatment of a cancer that is resistant to at least one anaplastic lymphoma kinase (ALK) kinase inhibitor are provided herein. The present invention is based on the discovery of mutations within ALK that confer resistance to at least one ALK kinase inhibitor. Polynucleotides... Agent: St. Jude Children's Research Hospital
20110256547 - Micrornaa (mirna) as biomarkers for diagnosing different grades of gliomas and pathways of glioma progression: This invention relates to a method for detecting, (i) malignant astrocytoma from normal brain tissue (ii) glioblastoma and anaplastic astrocytoma (iii) primary glioblastoma and secondary glioblastoma (iv) progressive pathway and denovo pathway comprises determining the level of expression of miRNAs listed in table 2, 3, 4, 5, wherein a higher... Agent: Department Of Biotechnology
20110256548 - Method for obtaining pancreatic progenitor cell using neph3: The present inventors successfully identified the surface marker Nephrin-like 3 (Neph3) which is specifically expressed in pancreatic progenitor cells, and isolated pancreatic progenitor cells using the marker as an indicator or such. Viable pancreatic progenitor cells can be selected by using Neph3 as an indicator without using translated products and... Agent: Eisai R&d Management Co., Ltd.
20110256549 - Novel reagents for directed biomarker signal amplification: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development... Agent: Sirigen, Inc.
20110256550 - Novel reagents for directed biomarker signal amplification: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development... Agent: Sirigen, Inc.
20110256551 - Systems and devices for analysis for samples: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety... Agent: Claros Diagnostics, Inc.
20110256552 - Method for preparing a substrate for immobilizing a cell, said substrate and uses thereof: The present invention relates to a method of preparation of a solid substrate capable of immobilizing at least one cell and/or at least one part of a cell, said method comprising a step consisting of fixing, to said solid substrate, a fusogenic compound capable of being inserted in cell membranes.... Agent:
20110256555 - Use of cxcr4 protein expression on the surface of stem cells as a marker for tumor tropic potential: The present invention relates to tumor tropic stem cells, and particularly to neural stem cells, and their use as delivery vehicles for therapeutic gene products to neoplastic foci. The stem cells with tumor tropic potential are selected based on the stem cells exhibiting CXCR4 receptors or an affinity for the... Agent: Cedars-sinai Medical Center
20110256556 - Humanized fcgr mice: Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low... Agent: Regeneron Pharmaceuticals, Inc.
20110256557 - Identifying parathyroid hormone agonists and antagonists: Provided herein are methods of screening for an agent that is a PTH agonist or antagonist. For example, provided is a method of screening for an agent that is a PTH agonist or antagonist, the method comprising contacting a cell with LRP6 and the agent to be screened, wherein the... Agent: The Uab Research Foundation
20110256558 - Measuring levels of fibrocystin-l: Nucleic acids encoding fibrocystin-L polypeptides and fibrocystin-L polypeptides are provided. Antibodies against the polypeptides, vectors and host cells containing the nucleic acids, methods for using the nucleic acids and polypeptides, and compositions and articles of manufacture also are provided.... Agent:
20110256553 - Methods: A method for assessing the effect of a test compound on LRRK2 in a cell-based system, the method comprising the steps of a) assessing the effect of exposing the cell-based system comprising LRRK2 to the test compound on the phosphorylation state of Ser910 and/or Ser935 of the LRRK2; and/or b)... Agent:
20110256554 - Methods for predicting pregnancy outcome in a subject by hcg assay: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin... Agent: The Trustees Of Columbia University In The City Of New York
20110256561 - Liver disease marker, method and apparatus for measuring the same, and method for assaying pharmaceutical preparation: A normal person (i.e. a control) and liver diseases such as drug induced liver injury, an asymptomatic hepatitis B carrier, an asymptomatic hepatitis C carrier, chronic hepatitis B, chronic hepatitis C, liver cancer, a nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and simple steatosis (SS) are identified by measuring... Agent: Keio University
20110256559 - Method for detecting soluble amyloid precursor protein (app) alpha and/or soluble app beta: The present invention relates to a method for detection or quantification of sAPPα and/or sAPPβ in a sample and their use for diagnosing and/or monitoring a neurodegenerative disease in a subject in need thereof and kit for use in said method.... Agent: Inserm (institut National De La Sante Et De La Recherche Medicale)
20110256560 - Methods and compositions for the detection of ovarian cancer: Provided is a method of screening for, diagnosing or detecting ovarian cancer in a subject comprising (a) determining a level of mdogen-2 in a test sample from the subject, and (b) comparing the level of mdogen-2 in the test sample with a control, where detecting an increase in the level... Agent: University Health Network
20110256563 - Method for detecting lysosomal storage diseases: A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood can be employed as a specimen. The assay... Agent: Seikagaku Corporation
20110256562 - Methods for diagnosing heart failure and other cardiac diseases: The invention relates to methods of diagnosing the severity of heart failure or a cardiac dysfunction in a subject. The invention further relates to monitoring the severity of heart failure in a subject and determining the prognosis of a subject that has suffered from heart failure. This invention also relates... Agent:
20110256564 - Methods, reagents and kits for luciferase assay: The invention relates to methods, reagents and kits for detecting enzyme activity using bioluminescence. In particular, it relates to a novel luciferase assay system with reduced background luminescence to allow for increased detection sensitivity. Provided is a method of detecting luciferase activity in a sample using coelenterazine or an analog... Agent: Perkinelmer Health Science B.v.
20110256565 - Methods for diagnosis and treatment of neurodegenerative diseases or disorders: The present invention provides methods that are useful for the diagnosis of neurodegenerative disease or disorder and for the screening of compounds or therapeutic agents for treating a neurodegenerative disease or disorder. The methods pertain in part to the correlation of a neurodegenerative disease or disorder with abnormal or altered... Agent:
20110256566 - Determination of biological material ingredients: The invention relates to a method for analysing ingredients, in particular lipids and/or vitamins and biological materials with a concentration of the biological material ingredients, to uses of relevant organic solvents or organic solvent mixtures, and to a spectrophotometer for measuring biological material ingredients. It is proposed to treat the... Agent:
20110256569 - Complex of a chaperone with beta-amyloid and methods employing this complex: A chaperone protein Q2 and β-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for determining the Q2 level in a biological sample... Agent:
20110256568 - Methods for the detection and/or quantification of gram positive bacterial contaminants: The invention provides methods and compositions for the detection and/or quantification of a Gram positive bacterial contaminant in a sample. In particular, the invention provides hemocyte-based preparations, methods of making such hemocyte-based preparations, and methods of using such hemocyte-based preparations for the detection and/or quantification of the Gram positive bacterial... Agent:
20110256570 - Method and kit for positively detecting toxic material: A method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles having competent mitochondrial enzymes formed from inner membranes of mitochondria, an electron donor which transmits electrons to an electron transfer system of the sub-mitochondrial particles and the sample, and forming reaction resultants, adjusting a... Agent: Samsung Electronics Co., Ltd.,
20110256572 - Biological sample discrimination apparatus, biological sample discrimination method, and biological sample discrimination plate: A plate on which a channel pattern is formed, which channel pattern includes a first channel into which a buffer agent is injected, and a second channel having, in a portion thereof, a quantification part that has a portion common to the first channel and holds a predetermined amount of... Agent:
20110256581 - Cell separation technique: In a first aspect, the present invention provides a method of removing non-viable cells from a cell population, said method comprising contacting a cell population with a compound under conditions suitable to permit binding between the compound and any non-viable cells present in the cell culture and removing at least... Agent:
20110256578 - Detection method using nanoaggregate-embedded beads and system thereof: The invention discloses a detection method using nanoaggregate-embedded beads and system thereof, which are characterized in that the nanoaggregate of Raman dye and metal nanoparticles is coated by an inorganic oxide to form a nanoaggregate-embedded bead, and which is then conjugated with a probe molecule to form a sensor bead.... Agent: National Chung Cheng University
20110256575 - Digital sampling apparatus and methods for sorting particles: A system and method for sorting a mixture of stained particles including a digital signal processor for analyzing and classifying the digital information generated from the particles and providing a sorting signal to a sorting system as a function of the analyzed and classified digital information.... Agent: Inguran, LLC.
20110256580 - Lc-mfr-ms-based method and apparatus for screening a new drug candidate: The present invention relates to a method for screening a new drug candidate using a liquid chromatography/microfluidic device/mass spectrometry system, and to a liquid chromatography/microfluidic device/mass spectrometry system. The present invention involves the detection of an interaction between molecules on a real-time basis through adjustment of a microreaction between traces... Agent: Korea Basic Science Institute
20110256573 - Method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample: A method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by an interior surface of a... Agent: Abbott Point Of Care, Inc.
20110256577 - Method for sensing a biochemical and/or biomechanical process of a biological material and method for analyzing biological materials: A method for sensing a biochemical and/or biomechanical process of a biological material, comprising the steps of: disposing at least a part of a microresonator into the biological material; and before, during, or after disposing the part of the microresonator into the biological material, sensing the process of the biological... Agent: Fujirebio Inc.
20110256579 - Method for verifying and/or identifying hormonally effective substances: The invention relates to a method for verifying and/or identifying hormonally effective substances using the pheromone system of yeast, to yeast cells for carrying out the method, and to the use thereof. The method according to the invention comprises the following steps: a) adding yeast culture medium or buffer to... Agent: Technische Universitaet Dresden
20110256582 - Method of classifying human subjects having adolescent idiopathic scoliosis (ais) and method for screening for a compound useful in the treatment of ais and related syndromes causing spinal deformities: A method of classifying a human subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting an impairment in melatonin-signaling pathway in the sample in the presence and in the absence of a known melatonin-signaling pathway agonist, whereby the results of the detecting step... Agent: Hopital Sainte-justine
20110256574 - Microfluidic continuous flow device: A microfluidic continuous flow device comprising a channel which comprises a first and a second area wherein the first area of the channel is a compartment which is defined by partitioning elements and the second area of the channel is a space outside the compartment; wherein through passages which are... Agent: Agency For Science, Technology And Research
20110256571 - Proteins: An amino acid sequence is described. The amino acid may comprise a signal sequence that is SEQ ID NO. 1a (or a variant or homologue or derivative or fragment thereof) that is expressed as a fusion protein that comprises a protein of interest. The signal sequence directs secretion of the... Agent:
20110256576 - Recovery and detection of microorganisms from mixed cellulose ester filtration supports by sequential treatment with methanol and acetone: The present invention is directed to the recovery of bacteria and microparasites, particularly Cryptosporidium and Giardia, from water samples by filtration through a mixed cellulose ester membrane, partial dissolution of said membrane with methanol followed by completion in the presence of acetone, and purification and concentration using glass beads as... Agent: Universite Laval
20110256584 - Culture medium for cultivation and identification of bacteria of genus pectinatus and method for taking swab samples: The present disclosure relates to a culture medium for cultivation and identification of bacteria of genus Pectinatus, which includes at least one source of carbon, at least one source of nitrogen, at least one source of amino-acids, at least one source of vitamins, at least one source of sulphur, at... Agent:
20110256583 - Method and medium for accelerating target analyte growth in a test sample: A reagent mixture and testing procedure for accelerating mixing of the formulation with a specimen sample being tested by effervescing when hydrolized, thereby causing an internal “stirring” of the reagent and the specimen sample. Examples of specimen samples that can be tested include nasal swabs and lesion swabs, environmental swabs,... Agent:
20110256585 - Mutant penicillin g acylases: The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected from the group consisting of amino acid positions A3, A77, A90, A144 A192,... Agent:
20110256586 - Methods and compositions for the prevention and treatment of anemia: Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a... Agent:
20110256587 - High affinity human antibodies to human nerve growth factor: A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or... Agent: Regeneron Pharmaceuticals, Inc.
20110256588 - Method of manufacturing rebaudioside a in high yield by recycling by-products produced from manufacturing process for rebaudioside a: The present invention relates to a method of producing Rebaudioside A in a high yield by recycling by-products produced when Rebaudioside A is produced from leaves of Stevia Rebaudiana Bertoni containing a sweetening material.... Agent: Cj Cheiljedang Corporation
20110256589 - T7 rna polymerase variants with enhanced thermostability: The present invention provides improved variants of T7 RNA polymerase by introducing novel mutations which lead to improved thermostability of the enzyme. According to the invention, amino acid substitutions at the positions Val426, Ser633, Val650, Thr654, Ala702, Val795, and combinations thereof are advantageous.... Agent:
20110256590 - Biochip, reactor, and reaction method: A biochip includes: a chamber that has a longitudinal direction; a holding unit that holds a liquid sample within a predetermined area of the chamber provided along the longitudinal direction, and releases the liquid sample from the predetermined area to an area inside the chamber by using a predetermined pressing... Agent: Seiko Epson Corporation
20110256591 - Individually synthesized primers to be used in whole genome amplification: Disclosed are compositions and methods for random amplification of nucleic acid sequences of interest using random-G-deficient primers. Also disclosed are methods of randomly amplifying a target nucleic acid sequence using random G-deficient primers alone or in combination with random, partially random, or specific primers.... Agent:
20110256592 - Use of cyclodextrins to improve the specificity, sensitivity and yield of nucleic acid amplification reactions: The invention is directed to methods for in vitro DNA synthesis catalysed by a DNA polymerase using cyclodextrins. The invention also relates to methods, compositions and kits comprising cyclodextrins for the amplification of a nucleic acid. The use of cyclodextrins improves the specificity, sensibility and/or yield of the amplification reaction.... Agent: Eurogentec S.a
20110256593 - Generation of random double-strand breaks in dna using enzymes: An enzyme preparation is described that includes a non-specific nuclease and a T7 Endo I mutant in a unit ratio of less than 1:200. This enzyme preparation may be used to generate double-stranded DNA fragments of a size suitable for DNA sequencing. The ends of the fragments can be readily... Agent: New England Biolabs, Inc.
20110256594 - Removal of nitrogen from a chlorophyll or pheophytin containing biomass: The present disclosure relates to refining a product from a biomass containing chlorophyll and/or pheophytins. In particular, a method of refining a product (such as a biofuel) from a photosynthetic organism is disclosed. The photosynthetic organism can be a naturally occurring organism or a genetically modified or altered organism. The... Agent: Sapphire Energy, Inc
20110256595 - Biofuel production: Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity... Agent: Bio Architecture Lab, Inc.
20110256596 - Manufacturing method of optically active d type lactic acid using byproducts prepared from rice polishing process: Disclosed is a method for manufacturing D type lactic acid wherein byproducts (e.g., rice bran and pulverized rice) obtained during a rice polishing process are saccharified by using α-amylase and amyloglucosidase and then fermented by a microorganism, Sporolactobacillus inulinus. According to the method, byproducts generated during a rice polishing process... Agent: Hyundai Motor Company
20110256597 - Membrane supported bioreactor for conversion of syngas components to liquid products: Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane under anaerobic conditions and transferring these components into contact with a biofilm on the opposite side of the membrane. These steps provide a... Agent:
20110256598 - Co-metabolism of fructose and glucose in microbial production strains: Recombinant microorganisms having an improved ability to co-metabolize in medium both fructose and glucose are described. The recombinant microorganisms comprise a promoter operably linked to a native or non-native nucleotide sequence that encodes a fucose:H+ symporter polypeptide. The recombinant microorganisms are useful for the production of a variety of products... Agent: E. I. Du Pont De Nemours And Company
20110256599 - Enhanced production of fatty acid derivatives: Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.... Agent: Ls9, Inc.
20110256600 - Recombinant microorganisms and methods of use thereof: The invention provides a recombinant microorganism capable of producing one or more products by fermentation of a substrate comprising CO, wherein the microorganisms has an increased tolerance to ethanol. The invention also provides, inter alia, methods for the production of ethanol and one or more other products from a substrate... Agent: Lanzatech New Zealand Limited
20110256601 - Modification of hydrogenase activities in thermophilic bacteria to enhance ethanol production: Bacteria consume a variety of biomass-derived substrates and produce ethanol. Hydrogenase genes have been inactivated m Thermoanaerobacterium saccharolyticum to generate mutant strains with reduced hydrogenase activities. One such mutant strain with both the ldh and hydtrA genes inactivated shows a significant increase in ethanol production. Manipulation of hydrogenase activities provides... Agent: The Trustees Of Dartmouth College
20110256602 - Method for biotechnological production of a hydrogen carrier: The invention relates to a method for biotechnological production of a hydrogen carrier. It is proposed to culture ammonium-producing cyanobacteria in which, by increasing the nitrogenase activity and/or blocking the utilization of ammonium in the cell metabolism and/or providing an exit mechanism for ammonium via the cell membrane, the ammonium... Agent: Linde Aktiengesellschaft
20110256603 - Apparatus and method of using an agricultural waste digester and biogas generation system: An agricultural waste digester and biogas generation system. The system includes a digester assembly having a cylindrical body, a hollow interior, a center axis and a plurality of wheel segments within the interior of the digester assembly. A gas conduit extends from the interior of the digester assembly to a... Agent:
20110256605 - Cells with non-natural physiologies derived by expressing light-powered proton pumps in one or more membranes: Methods and procedures for designing and constructing microbes with the ability to harvest light energy are described. In certain embodiments, these methods and procedures are used to construct a photosynthetic yeast based on proteorhodopsin (PR) expression. Proteorhodopsin is a light powered proton pump used by some ocean bacteria to scavenge... Agent: The Regents Of The University Of California, A California Corporation
20110256604 - Generation of asporogenous solventogenic clostridia: Expression of the SpoIIE gene in a solventogenic Clostridium cell is silenced and sporulation is abolished. The cell exhibits increased production of a solvent, such as butanol, relative to a wild-type solventogenic Clostridium cell and can be used for industrial-scale production of a chemical product. A method includes silencing the... Agent: University Of Delaware
20110256606 - Methods and compositions for increasing toxin production: The invention provides methods and compositions (such as for example, culture media) for culturing Clostridium difficile and producing the C. difficile Toxins A and B.... Agent: Sanofi Pasteur Biologics Co.
20110256607 - Homing endonucleases: The present disclosure provides, in part, polypeptides having endonuclease activity, nucleic acid sequences for such a polypeptide, target sequences for the endonuclease, as well as vectors, cells, kits, methods, and uses of the same.... Agent:
20110256608 - Modified variant bowman birk protease inhibitors: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing... Agent: Danisco US Inc.
20110256609 - Compositions and methods comprising variant microbial proteases: The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant subtilisins suitable for laundry cleaning applications.... Agent:
20110256610 - Compositions and methods comprising variant microbial proteases: The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant proteases suitable for laundry cleaning applications.... Agent:
20110256611 - Interferon beta production promoter and a method for producing thereof: An interferon β production promoter and a method for producing thereof are provided. The interferon β production promoter has a culture, a cell or cell components of lactic acid bacteria as an active ingredient thereof. RNA can be used for the cell component. In addition, bacteria belonging to the genus... Agent:
20110256612 - Compositions for culturing spirochetes: The present invention relates to methods and compositions for culturing spirochetes and treating spirochetal diseases. For example, the present invention provides serum-free media for culturing spirochete bacteria in vitro. The present invention further provides methods for identifying spirochete susceptibilities to antimicrobials and antimicrobial compositions and cocktails. The present invention also... Agent:
20110256613 - Designer proton-channel transgenic algae for photobiological hydrogen production: A designer proton-channel transgenic alga for photobiological hydrogen production that is specifically designed for production of molecular hydrogen (H2) through photosynthetic water splitting. The designer transgenic alga includes proton-conductive channels that are expressed to produce such uncoupler proteins in an amount sufficient to increase the algal H2 productivity. In one... Agent:
20110256614 - Method and system for processing organic matter in a poultry farm: The invention provides a method and system for processing organic matter that is produced in a poultry farm. The organic matter produced by the plurality of birds is removed from one or more containers that house the plurality of birds. The method further includes treating a first amount of organic... Agent: King Abdul Aziz City For Science And Technology
20110256615 - Modification of biomass for efficient conversion to fuels: A process is disclosed for preparing biomass particles for thermolytic or enzymatic conversion whereby the biomass particles baying a moisture content of at least 20% are subjected to flash heating. The flash heating may be preceded by one or more adsorption/desorption cycles with water or steam. A swelling aid may... Agent: Kior, Inc.
20110256616 - Cooling in a thermal cycler using heat pipes: A device for amplifying a nucleic acid sample may include a sample holder configured to receive a nucleic acid sample, a heating system configured to raise the temperature of the sample, a cooling system configured to lower the temperature of the sample, and a controller configured to operably control the... Agent: Life Technologies Corporation
20110256617 - Device for detecting the bacterial charge in a liquid or semi-liquid food product: A device (1) for detecting the bacterial charge in a liquid or semi-liquid food product comprises a main containment body (2), an analysis chamber (3), located inside the containment body (2) and designed to contain a certain quantity of product to be examined, one or more heating means (4) designed... Agent: Ali S.p.a. - Carpigiani Group
20110256618 - Nucleic acid sequencing methods and systems: Sequencing methods that use an exonuclease that comprises template dependent nucleobase binding activity are provided. Related compositions and sequencing systems are also provided.... Agent: Pacific Biosciences Of California, Inc.
20110256619 - Microfabricated compositions and processes for engineering tissues containing multiple cell types: The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.... Agent: The General Hospital Corporation
20110256621 - Colloidal magnetic nanobioparticles for cytotoxicity and drug delivery: The present invention provides systems that include magnetic colloidal particles of differing elemental compositions with differing morphologies. The colloidal particles comprise a magnetic material and a shell that surrounds the magnetic material. The colloidal particles can be inductively heated using a magnetic field. The present invention also provides applications of... Agent:
20110256620 - Nucleic acid encoding a self-assembling split-fluorescent protein system: The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with various combinations of self-complementing fragments derived from Aequorea victoria Green Fluorescent Protein (GFP), which are used to detect and quantify protein solubility in multiple... Agent:
20110256622 - Novel culture systems for ex vivo development: The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.... Agent:
20110256624 - Bioreactor: The invention relates to a bioreactor, to the use of the bioreactor for culturing microorganisms or cell cultures, and also to a method for culturing microorganisms or cell cultures.... Agent: Bayer Technology Services Gmbh
20110256623 - Primate embryonic stem cells: A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); and alkaline phosphatase (+). In a particularly advantageous embodiment, the cells of the preparation are human embryonic stem cells, have normal karyotypes,... Agent: Wisconsin Alumni Research Foundation
20110256625 - Liver engrafting cells, assays, and uses thereof: A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as... Agent:
20110256626 - Method for producing induced pluripotent stem cells with high efficiency and induced poluripotent stem cells prouced thereby: The present invention provides a method for producing customized pluripotent stem cells. Specifically, the present invention comprises following steps: extracting proteins from any of the dedifferentiated stem cells or induced pluripotent stem cells, the said dedifferentiated or pluripotent stem cells being prepared by any known method; introducing the protein extract... Agent: Seoul National University Hospital
20110256627 - Cutting device for culturing the next generation of cells: The present invention is related to a device for subculturing embryonic stem cells, which mainly contains a cutting brush having a handle and a brush stem. The brush stem has a stem and a plurality of discrete upright wires disposed on the stem. The brush stem is mounted onto a... Agent: Food Industry Research And Development Institute
20110256628 - Adaptive tissue engineering scaffold: The embodiments described herein include porous scaffolds formed from a stimuli-responsive polymer. The stimuli-responsive polymer of the scaffold creates a “smart” scaffold that changes properties in response to an effective stimulus applied to the stimuli-responsive polymer. In a preferred embodiment, an effective stimulus applied to the scaffold initiates a phase... Agent: The University Of Washington Through Its Center For Commercialization10/13/2011 > 114 patent applications in 70 patent subcategories.
20110250581 - Sperm cryoprotective media: Described herein is a composition that comprises a cryoprotectant; a membrane protectant that stabilizes or assists in stabilization of membranes of sperm; and a free radical scavenger (e.g., a reducing agent, an antioxidant).... Agent:
20110250582 - Methods and systems for gas production from a reservoir: A method and system for production of biogenerated gas from a zone in a reservoir are described. Microbial conversion of petroleum in the zone to biogenerated gas is stimulated. The biogenerated gas can be, for example, methane, hydrogen or carbon dioxide, or another gas. Gas including the biogenerated gas is... Agent:
20110250588 - Method for detecting cancer cells in blood sample: A method for detecting cancer cells in a blood sample is provided comprising the steps of proliferating an oncolytic virus at least in the cancer cells by incubating the blood sample being suspected to contain the cancer cells with the oncolytic virus; mixing the blood sample obtained from the proliferating... Agent: Sysmex Corporation
20110250584 - Method for screening cancer therapeutic agent using galectin-3, gsk-3betta, and fascin-1: Disclosed is a method for screening a novel cancer therapeutic agent. The cancer therapeutic agent exhibits down-regulation of galectin-3 and fascin-1 or interferes with the interaction between galectin-3 and GSK-3β.... Agent: National Cancer Center
20110250587 - Novel method for generation of rna virus: The present invention provides a method for generating negative-stranded segmented RNA viruses using linear expression constructs in the presence of helper virus.... Agent: Avir Green Hills Biotechnology Research Development Trade Ag
20110250583 - Optimized probes and primers and methods of using same for the binding, detection, differentiation, isolation and sequencing of influenza a; influenza b; novel influenza a/h1n1; and a novel influenza a/h1n1 rna sequence mutation associated with oseltamivi: Described herein are primers and probes useful for the binding, detecting, differentiating, isolating, and sequencing of influenza A, influenza B, 2009 influenza A/H1N1, and a 2009 influenza A/H1N1 RNA sequence mutation associated with oseltamivir resistance.... Agent: Intelligent Medical Devices, Inc.
20110250585 - Organ mimic device with microchannels and methods of use and manufacturing thereof: System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or... Agent: Children's Medical Center Corporation
20110250586 - System and method for concentrating samples: A system and method for concentrating samples. The system can include a first container adapted to contain a sample. The first container can include a first portion and a second portion adapted to be removably coupled to the first portion. The system can further include a second container comprising the... Agent:
20110250589 - Biomarkers for lung disease monitoring: The present invention pertains to the monitoring and treatment of lung transplant recipients. In particular, the invention pertains to the use of biomarkers to predict or detect post-lung transplantation complications (e.g., organ rejection, acute organ rejection, organ injury, bronchiolitis obliterans, bronchiolitis obliterans syndrome, organizing pneumonia), fibroproliferative repair responses, interstitial lung... Agent: The Regents Of The University Of Michigan
20110250591 - Method of designing sirnas for gene silencing: The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher... Agent: Merck Sharp & Dohme Corp.
20110250592 - Methods for determining a patient's susceptibility of contracting a nosocomial infection and for establishing a prognosis of the progression of septic syndrome: A method for determining a patient's susceptibility of contracting a nosocomial infection that includes obtaining a biological sample from the patient and extracting biological material from the biological sample; preparing a specific reagent of an expression product of at least one target gene selected from S100A9 and S100A8 target genes;... Agent: Biomerieux
20110250590 - Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof: The invention relates to methods and compositions for the differentiation of stromal cells from adipose tissue into hematopoietic supporting stromal cells and myocytes of both the skeletal and smooth muscle type. The cells produced by the methods are useful in providing a source of fully differentiated and functional cells for... Agent: Artecel, Inc.
20110250593 - Testing lumenectomy samples for markers of non-vascular diseases: Lumenectomy material is tested to determine the presence or likelihood of a condition of a patient. The lumenectomy material is in the form of at least one continuous tissue strand collected in vivo from an inner surface of a body lumen of the patient. The presence of at least one... Agent: Tyco Healthcare Group Lp
20110250595 - Analysis of single nucleotide polymorphisms using end labeling: A method for analyzing a sequence comprising a SNP site is provide. In general terms, the method comprises: a) contacting a first DNA sample with a first restriction enzyme to provide DNA fragments, wherein: i) the first restriction enzyme cleaves the sequence only if a first allele of a SNP... Agent: Agilent Technologies, Inc.
20110250601 - Bisulfite conversion of dna: The present invention provides an improved method for the bisulfite conversion of DNA, and facilitates the analysis of cytosine methylation of genomic DNA. Novel combinations of denaturing solvents, new reaction conditions and new purification methods provide surprisingly efficacious methods for bisulfite conversion of DNA relative to prior art methods. The... Agent: Epigenomics Ag
20110250598 - Detergent free polymerases: The present invention relates to a formulation of a thermostable DNA polymerase which is completely free of detergents and its particular use in real time polymerase chain reaction (PCR). Such a formulation may be obtained if the selected purification method does not require the addition of a detergent at any... Agent:
20110250597 - Digital analyte analysis: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from... Agent: Raindance Technologies, Inc.
20110250600 - Marker for cancer prognosis and methods related thereto: The present invention is related to the novel discovery that HIF-2α, but not HIF-1α, selectively regulates adenosine A2A receptor in endothelial cells, thereby revealing a unique and hitherto unknown pathway by which HIF-2αcan regulate angiogenesis independent of HIF-1α. This discovery allows for design of new diagnostic tools and novel therapies... Agent: National Jewish Health
20110250599 - Methods and compositions to detect nucleic acids in a biological sample: Methods of the invention separate a target nucleic acid from a sample by using at least one capture probe oligonucleotide that contains a target-complementary region and a member of a specific binding pair that attaches the target nucleic acid to an immobilized probe on a capture support, thus forming a... Agent: Gen-probe Incorporated
20110250602 - Methods and computer software products for identifying transcribed regions of a genome: Methods and computer software products are provided for transcriptional annotation. In one embodiment of the invention, a region of the genome where the intensity of hybridization of all the probes are above a threshold value (usually the level of non-specific hybridization) is identified. The region may be identified by aligning... Agent: Affymetrix, Inc.
20110250594 - Methods for genetic analysis of textiles made of gossypium barbadense and gossypium hirsutum cotton: Methods for distinguishing between cotton species by analyzing a sample of mature cotton fibers from raw cotton materials or from textile goods are disclosed. DNA is extracted from the mature cotton fiber sample and subjected to PCR techniques which enable the identification of the species of cotton utilized in the... Agent:
20110250596 - Methods, kits and compositions pertaining to linear beacons: This invention is directed to methods for determining amplified nucleic acid using Linear Beacons... Agent: Life Technologies Corporation
20110250605 - Genotyping hla loci: This invention provides for an improved method for genotyping HLA loci using PCR.... Agent: Linkage Biosciences, Inc.
20110250603 - Methods for sequencing individual nucleic acids under tension: The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.... Agent: Life Technologies Corporation
20110250604 - Methods of detecting sources of microorganism contamination: Methods of detecting a source of a microbial contamination in a suspect sample include detecting at least one member selected from the group consisting of a microbial geosmin synthase, a microbial 2-methylisoborneol synthase and a microbial 2-methylgeranyl diphosphate synthase in the suspect sample. The method can include conducting a nucleic... Agent:
20110250606 - Method for the identification of carcinogenic compounds: The present invention relates to methods for the identification of genotoxic carcinogenic compounds. In particular, a method is disclosed for the identification of genotoxic carcinogenic compounds wherein a eukaryotic cell is exposed to a potentially genotoxic compound in a culture medium where after samples are taken from the cell and/or... Agent: Universiteit Maastricht
20110250607 - Yeast-based methods of identifying nucleic acids and compounds for treating neurodegenerative diseases: The disclosure encompasses methods for the screening of small molecules or nucleic acids that may reverse the inhibition of growth of the unicellular yeast Schizosaccharomyces pombe by rotenone. The use of a yeast as the screening target allows for the high-throughput screening of small molecule and nucleic acid libraries for... Agent:
20110250608 - Use of ultraconserved rna in detection and treatment of cancer: A method of analyzing a biological specimen to detect cancer in a subject, involving determining an ultraconserved RNA in the specimen and comparing the expression level to a control. The ultraconseved RNA may be uc.338 and may be used to detect hepatocellular cancer. Transcript RNA encoding ultraconserved RNA may also... Agent: The Ohio State University
20110250609 - Methods for the detection, analysis and isolation of nascent proteins: This invention relates to non-radioactive markers that facilitate the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Nascent proteins containing these markers can be rapidly and efficiently detected, isolated and analyzed without the handling and disposal problems associated with radioactive reagents. Preferred markers are dipyrrometheneboron... Agent:
20110250610 - Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes: Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.... Agent: Butamax(tm) Advanced Biofuels LLC
20110250611 - Immunoglobulin display vectors: Disclosed are mammalian expression vectors for expressing simultaneous expression of immunoglobulins as both a secreted and cell surface bound form.... Agent: Abbott Biotherapeutics Corp.
20110250612 - Novel centromeric protein shugoshin: The present invention is to provide meiosis-specific novel kinetochore protein Sgo1 (shugoshin) derived from fission yeast Schizosaccharomyces pombe, and a homologue or paralogue thereof having a regulatory activity of chromosome segregation; and DNAs encoding them; as a factor ensuring the retention of unidirection and cohesion in sister centromere at meiosis... Agent: Japan Science & Technology Agency
20110250613 - Arrayed multiple ubiquitin binding domains as linkage-specific polyubiquitin affinity reagents: Linkage-specific polyubiquitin recognition is thought to make possible the diverse set of functional outcomes associated with ubiquitination. Thus far, mechanistic insight into this selectivity has been largely limited to single domains that preferentially bind to lysine 48-linked polyubiquitin (K48-polyUb) in isolation. A mechanism is proposed herein, linkage-specific avidity, in which... Agent: The Johns Hopkins University
20110250614 - Methods and compositions for detecting the activation state of multiple proteins in single cells: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The... Agent:
20110250615 - Methods and compositions for detection of ehrlichia chaffeensis (vlpt): The invention provides methods and compositions for the detection of Ehrlichia chaffeensis.... Agent: Idexx Laboratories, Inc.
20110250617 - Device and analyzing system for conducting agglutination assays: A device for conducting an agglutination assay comprising several reaction vessels, each reaction vessel comprising an upper chamber having an opening for accepting reactants and/or a sample; and a lower chamber comprising an end in communication with the upper chamber for receiving fluids from the upper chamber, a closed end... Agent: Symbion Medical Systems Sarl
20110250616 - Electroactive surface-confinable molecules: The invention provides compositions, kits, methods, and species that include electroactive entities which can serve as signaling entities in chemical and/or biochemical assays. The electroactive species can be metallocenes, such as ferrocenes, including substituents that affect the oxidation/reduction potential (redox potential) of the species. By controlling the redox potential of... Agent:
20110250618 - Biomarkers and assays for diabetes: The present invention is directed to novel biomarkers and combinations thereof. The present invention also provides assays and data evaluation methods related to the detection and monitoring of diseases, particularly, diabetes. In particular, the biomakers in accordance with the present invention include, but are not limited to, modified forms of... Agent: Arizona Board Of Regents, For And On Behalf Of Arizona State University
20110250619 - Methods of detecting antibodies specific for denatured hla antigens: The invention is directed to methods of screening for HLA antibodies comprising detecting antibodies specific for native HLA antigens and denatured HLA antigens. The invention also provides for methods of removing antibodies specific for denatured HLA antigens or antibodies specific for native HLA antigens from a serum sample. In addition,... Agent: One Lambda
20110250620 - Methods of evaluating an immune response to an antigen: The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an... Agent: Sanofi Pasteur Vaxdesign Corporation
20110250621 - Method for in vitro assay of the circulating tissue factor, and use in the detection of coagulation diseases: The invention concerns the field of hemostasis, in particular blood coagulation disorders linked to an abnormal expression of tissue factor, and to physiopathological phenomena correlated with over-expression of the factor. The present invention provides a method for assaying the activity of circulating tissue factor in a biological sample. The method... Agent: Diagnostica Stago
20110250623 - Biomarker and method for detecting a chronic inflammatory-associated disease: The present invention in one embodiment uses detection of isoforms of CAP37 as an early detection marker for a chronic inflammatory-associated disease. Chronic inflammatory-related diseases may include, for example, atherosclerosis, psoriasis, and osteoarthritis. The invention is also directed to isoforms of CAP37 protein having apparent molecular weights of about 135... Agent:
20110250624 - Elisa assay for detecting antibodies against blv surface antigen gp 51 in bovine serum: The subject of the present invention is a method of obtaining purified BLV gp51 antigen as well as a novel ELISA assay using said antigen. The present invention is useful in the diagnosis of enzootic leukaemia in cattle.... Agent:
20110250625 - Gamma secretase notch biomarkers: The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized before, after, or concurrently with, pre-clinical,... Agent: Bristol-myers Squibb Company
20110250622 - Method for diagnosing auto-immune chronic urticaria: In certain embodiments, the present invention relates to methods, compositions, and kits for diagnosing autoimmune chronic urticaria. For example, in certain embodiments, such methods generally comprise detecting the presence of auto-antibodies to cell-surface IgE receptors or cell-bound IgE in a patient. Such auto-antibodies may be detected by (a) obtaining donor... Agent:
20110250626 - Visual assays for coatings incorporating bioactive enzymes for catalytic functions: Disclosed herein are materials such as a coating, comprising a lipolytic enzyme or organophosphrous compound degrading enzyme. Also disclosed herein are methods of visually detecting enzyme activity in a coating by contacting the coating with a substrate of an enzyme and a visual indicator that changes appearance upon production of... Agent: Reactive Surfaces, Ltd.
20110250627 - Methods for assaying percentage of glycated hemoglobin: The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular... Agent: General Atomics
20110250629 - Alcohol production process: The invention relates to the microbial fermentation of gaseous substrates, particularly to methods of mitigating and/or reducing alcohol toxicity effects on a microbial culture at elevated alcohol concentrations during fermentation. The invention relates particularly to microbial fermentation of substrates comprising CO and the effects of alcohol toxicity are reduced or... Agent: Lanza Tech New Zealand Limited
20110250628 - Hcv replicons containing ns5b from genotype 2b: The present invention features methods for enhancing the ability of a genotype 2b NS5B sequence to function in a replicon, for producing replicons containing a functional genotype 2b NS5B, and for using replicons to measure the ability of a compound to affect HCV replication that is sustained with the genotype... Agent:
20110250632 - Methods for conducting cellular assays: The present invention relates to cryopreserved cell cultures, methods for cryopreserving cells and methods for conducting cellular assays on such cells. A cryopreserved cell culture of the invention comprises a container having at least a surface which is coated with poly-lysine and frozen cells supported on the surface.... Agent: Ge Healthcare Uk Limited
20110250630 - Motif-grafted hybrid polypeptides and uses thereof: Provided herein are hybrid polypeptides that specifically bind to a disease-associated isoform of a polypeptide involved in diseases of protein aggregation. The hybrid polypeptides can be used for diagnosis and treatment of such diseases. In a particular embodiment, a hybrid protein that specifically binds to the infectious form of a... Agent:
20110250631 - Proteoglycan degrading mutants for treatment of cns: The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.... Agent:
20110250633 - Device and method for automatically analyzing micro organisms in a sample: Device for automatically analyzing micro organisms in an aqueous sample using filter cytometry comprising at least one filter holder and processing modules, wherein the filter holder is arranged to contain a filter for receiving the sample, wherein the processing modules comprise sample application means for applying the sample to the... Agent:
20110250634 - Tissue container for molecular and histology diagnostics incorporating a breakable membrane: A container for storing a biological sample for molecular diagnostic testing and/or histological testing is provided. The container includes a first chamber for receiving a sample holder therein, a second chamber, and a closure for enclosing the container. A breakable membrane, such as a piercable foil, extends within the container... Agent: Becton, Dickinson And Company
20110250635 - Method and system for processing biomass: A method and system for processing biomass. The method uses an apparatus with a housing, a rotor inside of the housing, and a plurality of protrusions extending from the rotor. The method includes placing the biomass in a fluid medium, inducing cavitation within the fluid to partially separate the biomass,... Agent:
20110250637 - Method for producing sugar liquid: A sugar liquid containing only very small amounts of fermentation-inhibiting substances is produced by a method for producing a sugar liquid using a cellulose-containing biomass as a raw material, the method including: (1) a step of hydrolyzing a cellulose-containing biomass to produce an aqueous sugar solution; and (2) a step... Agent: Toray Industries, Inc.
20110250636 - Novel gene gms 01: The present invention relates to microorganisms genetically engineered to increase yield and/or efficiency of biomass production from a carbon source, such as e.g. glucose. Processes for generating such microorganisms are also provided by the present invention. The invention also relates to polynucleotide sequences comprising genes that encode proteins that are... Agent: DsmIPAssets B.v.
20110250638 - Lignocellulosic biomass conversion: The present invention relates to a process for the production of second generation biofuels and/or sugar based chemicals—for example ethanol, butanol etc—and/or materials—for example plastics, single cell proteins etc.—together with sulfonated lignin from lignocellulosic biomass, in particular from lignocellulosic biomass comprising, among others, annual plants, agricultural waste, or wood. In... Agent: Borregaard Industries Limited, Norge
20110250640 - Method of recloning production cells: A new method for selecting clones and recloning mammalian cells which are of importance for the production of biopharmaceuticals, preferably hamster or mouse myeloma cells, with a high degree of automation and throughput. The invention relates to methods of depositing and replicating single cell clones of the cells in question.... Agent: Boehringer Ingelheim Pharma Gmbh & Co. Kg
20110250639 - Methods for producing soluble membrane-spanning proteins: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in... Agent:
20110250641 - Zwitterionic acid-labile surfactants and methods of use: wherein R1 is independently selected from C1-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, Y− is an anion, m is an integer from 1 to 8 and n is an integer from 1 to 8 is described.... Agent:
20110250643 - Antibody composition-producing cell: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for... Agent: Kyowa Hakko Kirin Co., Ltd.
20110250642 - Method for displaying antibodies: There is disclosed vector designs, constructs and approaches to construct antibody libraries that display antibodies, such as full-length immunoglobulins, single chain antibody (SCA) scFv, or Fab on the host cell surface. There is also disclosed screening approaches to isolate desired antibody binders from above mentioned antibody libraries for selective antibody... Agent: Sorrento Therapeutics
20110250644 - Feed supplement for mammalian cell culture and methods of use: An improved feed supplement for culture of mammalian cells used to produce proteins is provided. The improved supplement is devoid of animal-derived components and protein hydrolysates. The invention also provides methods of using the supplement in production of a therapeutic proteins, such as an antibody. In some embodiments, the antibody... Agent: Schering Corporation
20110250646 - Ammonia pretreatment of biomass for improved inhibitor profile: Methods for treating biomass for release of fermentable sugars with an improved inhibitor profile are provided. Specifically, a hydrolysate comprising fermentable sugars with an improved inhibitor profile is obtained by saccharification of a reaction product obtained by pretreating biomass with ammonia under suitable reaction conditions. The pretreated biomass reaction product... Agent: E.i. Du Pont De Nemours And Company
20110250645 - Methods to improve monomeric sugar release from lignocellulosic biomass following alkaline pretreatment: A method is provided for improving the release of monomeric sugars from alkaline pretreated biomass. The method includes further processing of pretreated biomass and addition of a chemical to the saccharification reaction, which together provides for unexpected release of high levels of monomeric sugars that may be fermented to target... Agent: E.i. Du Pont De Nemours And Company
20110250647 - Corynebacterium genus microorganism having ability to produce n-acetyl glucosamine and method for producing n-acetyl glucosamine or glucosamine using the same: The present invention relates to a microorganism of the Corynebacterium genus that produces N-acetyl glucosamine which retains the activity of 6-phophate acetyltransferase and a method for producing N-acetyl glucosamine or glucosamine using the same.... Agent: Cj Cheiledang Corporation
20110250648 - Compositions and methods for inhibiting terminal transferase activity: The present invention relates to systems and methods for amplifying nucleic acid. In particular, systems and methods are provided for inhibiting polymerase based terminal transferase activity within a polynucleotide amplification setting (e.g., polymerase chain reaction). In addition, systems and methods are provided for generating amplified products generated with polynucleotide amplification... Agent: Lbis Biosciences, Inc.
20110250649 - Pcr-based method of synthesizing a nucleic acid molecule: There is provided a method of synthesizing a nucleic acid molecule and in one aspect, the method comprises assembling a full length template nucleic acid molecule by PCR in a PCR reaction mixture comprising a set of assembly oligonucleotides having a first average melting temperature and a set of outer... Agent: Agency For Science, Technology And Research
20110250650 - Lentiviral vectors for the preparation of immunotherapeutical compositions: The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or... Agent:
20110250651 - Corynebacteria strain for enhancement of 5'-guanosine monophosphate productivity and a method of producing 5'-guanosine monophosphate using the same: Disclosed is a method of producing 5′-guanosine monophosphate using a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type, thereby showing improved ATP productivity. Also, a novel microorganism is disclosed. The method comprises: culturing the corynebacteria strain which is enhanced in malate dehydrogenase activity over... Agent: Cj Cheiljedang Corporation
20110250652 - Process for production of an enzymatic preparation for hydrolysis of cellulose from lignocellulosic residues and application thereof in the production of ethanol: The process of the present invention is based on the microbial production of enzymes from the growth of the fungus Penicillium funiculosum in a suitable culture medium with a cellulosic substrate. The process of the invention comprises in particular the fermentative treatment of a lignocellulosic substrate by means of a... Agent: Petroleo Brasileiro S.a.- Petrobras
20110250653 - L-succinylaminoacylase and process for producing l-amino acid using it: The present invention provides a L-succinylacylase consisting of: (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2; (c) a protein coded by a polynucleotide which... Agent: Toyo Boseki Kabushiki Kaisha
20110250654 - Microaerobic cultures for converting glycerol to chemicals: Glycerol or other reduced carbon sources may be used as a feedstock for the microbial production of chemical products under certain microaerobic conditions. For example, such production may occur under microaerobic or microrespiratory conditions in which electron acceptors are consumed in the reaction as quickly as they are added. In... Agent: William Marsh Rice University
20110250655 - Biocatalysts for manufacturing duloxetine alcohol: The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use... Agent: Basf Se
20110250656 - Production of monascus-like azaphilone pigment: The present invention relates to the field of biotechnological production of polyketide based colorants from filamentous fungi, in particular a method for preparing a biomass comprising a Monascus-like pigment composition from a nontoxigenic and non-pathogenic fungal source. The present invention further relates to use of the Monascus-like pigment composition as... Agent: Dtu, Technical University Of Denmark
20110250657 - Processes for making [r]-ethyl 4-cyano-3 hydroxybutyric acid: The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hydroxybutyrate by whole cell processes, cell lysate processes, “one pot processes” and “multi-pot” processes using a variety of parameters.... Agent: Verenium Corporation
20110250659 - Modified photosynthetic microorganisms for producing lipids: This disclosure describes genetically modified photosynthetic microorganisms, e.g., Cyanobacteria, that contain one or more exogenous genes encoding a phospholipase and/or thioesterase, which are capable of producing an increased amount of lipids and/or fatty acids. This disclosure also describes genetically modified photosynthetic microorganisms that contain one or more exogenous genes encoding... Agent: Targeted Growth, Inc.
20110250658 - Recombinant microalgae cells producing novel oils: Disclosed herein are obligate heterotrophic microalgae cells containing an exogenous gene. In some embodiments the gene is a sucrose utilization gene, and further disclosed are methods of manufacturing triglyceride oils using sugar cane or sugar beets as a feedstock in a heterotrophic fermentation. In other embodiments the feedstock is depolymerized... Agent: Solazyme, Inc.
20110250660 - Method for producing aldehyde from co2: The invention provides recombinant microorganisms capable of producing isobutyraldehyde using CO2 as a carbon source. The invention further provides methods of preparing and using such microorganisms to produce isobutyraldehyde.... Agent: The Regents Of The University Of California
20110250663 - Methods and compositions related to fatty alcohol biosynthetic enzymes: Compositions and methods for producing fatty acid derivatives using recombinant microorganisms are described herein.... Agent: Ls9, Inc.
20110250661 - Methods for gasification of carbonaceous materials: The present disclosure is generally directed to process of gasification of carbonaceous materials to produce synthesis gas or syngas. The present disclosure provides improved methods of gasification comprising: adding one or more carbonaceous materials, adding a molecular oxygen-containing gas, adding a methane-containing gas and optionally adding water or steam into... Agent:
20110250662 - Methods for gasification of carbonaceous materials: The present disclosure is generally directed to process of gasification of carbonaceous materials to produce synthesis gas or syngas. The present disclosure provides improved methods of gasification comprising: adding one or more carbonaceous materials, adding a molecular oxygen-containing gas, adding carbon dioxide gas and optionally adding water into said gasifier.... Agent:
20110250664 - Yeast having improved ethanol yield: The present invention provides for a genetically-altered haploid yeast cell characterized by reduced activity or expression of FPS1, reduced activity or expression of glycerol-3-phosphate dehydrogenase-1 (GPD1), reduced activity or expression of glycerol-3-phosphate dehydrogenase-2 (GPD2), and increased expression of glutamate synthase (GLT1), wherein the reduced activity or expression, and the increased... Agent: Tianjin University
20110250665 - Ethanol production process and yeast for ethanol production: According to the present invention, ethanol production is carried out with the use of cellulose or cellobiose as a starting material at low cost. The method of the present invention comprises the steps of culturing a microorganism that is classified as a species selected from the group consisting of Ogataea... Agent: Toyota Jidosha Kabushiki Kaisha
20110250666 - Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria: The present invention provides methods and compositions for producing isoprene hydrocarbons from microalgae, cyanobacteria, and photosynthetic and non-photosynthetic bacteria.... Agent: The Regents Of The University Of California
20110250667 - Fossil fuel-free process of lignocellulosic pretreatment with biological hydrogen production: The invention provides an isolated haloalkaliphilic microorganism designated as strain sapolanicus belonging to the genus Halanaerobium, which is capable of producing hydrogen from biomass. Methods of producing biohydrogen comprising the fermentation of the microorganism with alkaline pretreated biomass are also provided. Fermentation is preferably carried out without neutralization of the... Agent: The Curators Of The University Of Missouri
20110250668 - Protein for constructing protein complex from clostridium thermocellum, and use thereof: It is an object to provide a protein having a dockerin, which is suited to production in yeasts and other eukaryotic microorganism in which sugar chain modification is predicted, and which provides excellent cohesin-dockerin binding ability, along with a use thereof. The present invention uses, as a protein for constructing... Agent: Kabushiki Kaisha Toyota Chuo Kenkyusho
20110250669 - Method and apparatus for selectively targeting specific cells within a cell population: This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every detectable cell in a population can be identified and affected, without substantially... Agent: Cyntellect, Inc.
20110250670 - Light energy-induced stability of biomaterials: Disclosed are methods and apparatuses for stabilizing labile biomolecules in an aqueous solution without the use of chemicals. For example, some embodiments involve exposing an aqueous solution of a labile biomolecule, such as a protein, to light energy to stabilize the biomolecule in the solution.... Agent: University Of Calcutta
20110250671 - Glucose dehydrogenase and method for producing the dehydrogenase: A DNA encoding a glucose dehydrogenase enzyme having high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is described. Cells transformed with the DNA encoding the glucose dehydrogenase enzyme may be used... Agent:
20110250672 - Mutant dna polymerases and uses therof: The present invention relates to mutant DNA polymerases which incorporate dideoxynucleotides with about the same efficiency as deoxynucleotides. The present invention also related to mutant DNA polymerases which also have substantially reduced 5′-to-3′ exonuclease activity or 3′-to-5′ exonuclease activity. The invention also relates to DNA molecules coding for the mutant... Agent: Life Technologies Corporation
20110250673 - Facilitated process for purification of proteins: A two-stage heat treatment process is provided to improve the processability of recombinant microbial biomass comprising an enzyme having perhydrolytic activity. More specifically, a process is provided to treat the recombinant microbial biomass comprising a Thermotoga sp. acetyl xylan esterase having perhydrolytic activity such that microfiltration may be used to... Agent:
20110250674 - Cellulase variants: t
20110250675 - Virus-like particle mediated cellular delivery: The invention provides compositions and methods for delivering compounds to cells. The invention is directed, in part, to virus-like particles which contain biological materials such as carbohydrates, proteins and nucleic acids. The invention is also directed, in part, to methods for delivering compounds to cells involving contacting cells with the... Agent: Life Technologies Corporaiton
20110250676 - Composition and method for bioremediation of deicing fluids: The present invention is a kit and method for bioremediation of deicing fluids containing glycol. Using a combination Bacillus, Pseudomonas, yeast and filamentous fungi strains selected for the ability to grow on high levels of glycol, bioremediation of airport runoff is provided.... Agent:
20110250677 - Apparatus for assessing the effectiveness of a sterilization process: A device useful in determining the efficacy of a chemical sterilization process includes a dead end cavity closed by an access cap having a port coupled to a challenge tube defining the only path by which a substantial quantity of sterilant can reach the cavity. A biological indicator is located... Agent: Sterilucent, Inc.
20110250678 - System for producing gas from organic waste: A system for producing gas from organic waste includes a pretreatment unit, which crushes organic waste; an oxidation unit, which oxidizes the crushed organic waste in an oxidation bath; an oxidation unit, which converts the oxidized organic waste into fluid by anaerobic digestion; and a stabilization unit, which divides the... Agent:
20110250680 - Automated system for the lysis of microorganisms present in a sample, for extraction and for purification of the nucleic acids of said microorganisms for purposes of analysis: a cartridge, of roughly cylindrical shape, having a microorganism retention zone, said retention zone having means for lysis of the microorganisms, said cartridge being positioned within said air collecting module.... Agent: Biomerieux
20110250679 - Methods and compositions for high-resolution micropatterning for cell culture: Composite structures and methods for generating micropatterned materials suitable for use in cell culture applications are disclosed. The improvement of these compositions and methods over the prior art is based on the unexpected discovery that minor chemical modifications can be introduced to greatly enhance the adherence and/or stability of a... Agent: The Regents Of The University Of California
20110250681 - Fc variants with optimized properties: The present invention relates to Fc variants with optimized properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized properties, and methods for using Fc variants with optimized properties.... Agent: Xencor, Inc.
20110250682 - Formation of neuromuscular junctions in a defined system: A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more rat muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a rat muscle... Agent: University Of Central Florida Research Foundation, Inc.
20110250683 - Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.... Agent: Battelle Energy Alliance, LLC
20110250684 - Method for producing neural stem cells: In order to provide a method for producing neural stem cells easily and quickly by inducing differentiation of somatic cells directly into neurospheres, dedifferentiation factors are introduced into somatic cells, which are then cultured in suspension in the presence of growth factors to produce the neurospheres, thereby allowing the neural... Agent: Keio University
20110250685 - Compositions and methods for enhancing cellular transport of biomolecules: The present invention discloses compositions and methods for delivery of biomolecules into cells. Compositions comprise peptidomimetic macrocycles complexed or conjugated to biomolecules such as nucleic acids.... Agent:
20110250686 - Novel hepatocyte-like cells and hepatoblast-like cells derived from hbs cells: The present invention relates to a novel hepatocyte-like cell population derived from hBS cells and to the potential use of such heopatocyte-like cells in e.g. medical treatment, drug screening and toxicity testing. Furthermore, the invention relates to 5 hepatoblast-like cells that may have suitable characteristics so that they can be... Agent: Cellartis Ab
20110250687 - Cell adhesion inhibitor (cai) with combination growth factors mobilization of peripheral blood mononuclear cells for cai derived dendritic cell (cddc) preparation and dendritic cell vaccine preparations generated from cddc: Disclosed is a method to recover a dendritic cell rich mixture from peripheral blood mononuclear cells (PBMC) mobilized with one or more cell adhesion inhibitors (CAI) for the preparation of a dendritic cell vaccine. The CAI derived dendritic cell rich mixture (CdDC) from PBMC can either be used alone or... Agent:
20110250688 - Three dimensional tissue generation: Methods and materials for generating a three-dimensional tissue construct are provided. The method comprises (a) providing a tissue scaffold; (b) providing isolated smooth muscle cells; (c) suspending the isolated cells in hydrogel; (d) ejecting the cell/hydrogel suspension from a printer onto the tissue scaffold; and (e) incubating the cells on... Agent: Immunotrex Corporation
20110250689 - Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof: The invention relates a multilayer preform obtained by electro-spinning, which preform is suitable as a scaffold for a prosthesis, which preform comprises at least one layer of microfibres and at least one layer of nanofibres, wherein the pore size of the at least one layer of microfibres is in the... Agent:
20110250690 - Microfluidic embryo and gamete culture systems: A robotic microfluidic incubator system has a thin transparent sidewall and close proximity of the embryo/oocyte/cultured cells to the sidewall allow close approach of a side view microscope with adequate focal length for mid to high power. This arrangement permits microscopic examination of multiple culture wells when arranged in rows... Agent:
20110250691 - Culture medium for myoblasts, precursors thereof and derivatives thereof: This application relates to a serum-free culture medium that enables the proliferation of cell of the myogenic lineage while maintaining their ability to differentiate into functional muscle cells. Also contemplated herewith are method of culturing cells of the myogenic lineages and uses of the cultured cells for the treatment or... Agent:
20110250693 - Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (mva): The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA... Agent:
20110250692 - Method for producing induced pluripotent stem cells: The present invention relates to a method for producing mammalian induced pluripotent stem cells, comprising introducing mammal-derived reprogramming factors comprising Oct3/4 and Nanog, or nucleic acids encoding Oct3/4 and Nanog, into mammal-derived somatic cells and thereby inducing induced pluripotent stem cells from the somatic cells, wherein the reprogramming factors comprise... Agent: Kyoto University
20110250694 - Eukaryotic expression vectors resistant to transgene silencing: The present invention relates to recombinant DNA molecules such as plasmids, non-viral vectors, viral vectors and hybrids thereof, and more particularly to vector modifications that improve expression of said DNA molecules in cell lines and organisms.... Agent: Nature Technology Corporation10/06/2011 > 134 patent applications in 69 patent subcategories.
20110244443 - Methods, systems and devices for separating tumor cells: Embodiments of the present disclosure are directed to the separation/capture of specific cells and/or contaminants, as well as the determination, monitoring, and treatment of cancer. Moreover, some embodiments are directed to methods, systems and devices for removing cancer, stem and/or tumor cells in vivo or in vitro from a bodily... Agent: Viatar LLC
20110244444 - Methods of multiplying plant embryogenic tissue in a bioreactor: The present invention provides methods of multiplying plant embryogenic tissue in a bioreactor.... Agent: Weyerhaeuser Nr Company
20110244445 - Mass spectroscopy analysis of mutant polypeptides in biological samples: The invention relates to a method for determining the presence of at least one distinct polypeptide in a biological sample comprising contacting the biological sample with a hydrolyzing agent, wherein the hydrolyzing agent is capable of hydrolyzing the distinct polypeptide in a sequence-specific manner such that at least one distinct... Agent: Cell Signaling Technology, Inc.
20110244447 - Cognate sampling kinetics: Provided are methods and compositions for measuring the transient binding of nucleotides and nucleotide analogs under conditions where the nucleotides or nucleotide analogs are unincorporable. The transient binding can be determined under single molecule observation conditions providing information about the kinetics of nucleotide analog sampling of the active site of... Agent: Pacific Biosciences Of California, Inc.
20110244448 - Dna detecting apparatus, dna detecting device and dna detecting method: A chemiluminescence detecting apparatus includes a thing called a plate where many reaction chambers are one-dimensionally or two-dimensionally arranged, and enzymes packed in a gel and DNA-immobilized beads are simultaneously charged into the reaction chambers, thereby trapping a large amount of enzymes in the reaction chambers, improving enzyme activity and... Agent:
20110244449 - Methods of determining copy number of a genetic locus: Disclosed are methods of determining in a sample, the molar ratio of a query locus to a reference locus, comprising: 1) forming one or more mixtures, each mixture comprising: a) a reference-query coupled probe comprising a nucleobase polymer comprising i) a probe reference locus comprising a probe reference allele, and... Agent:
20110244450 - Primate totipotent and pluripotent stem cells produced by somatic cell nuclear transfer: Purified totipotent stem cells and pluripotent stems cells derived by somatic cell nuclear transfer are disclosed herein, as well as cell lines, multipotent cells and differentiated cells produced from these stem cells. The stem cells are produced from an enucleated host cell from a first donor and nuclear genetic material... Agent: Oregon Health & Science University
20110244446 - Rna sequence-specific mediators of rna interference: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long... Agent:
20110244455 - Digital analyte analysis: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from... Agent: Raindance Technologies, Inc.
20110244454 - Freeze-dried compositions for biochemical reactions: The use of raffinose as a glass-forming agent for freeze-dried compositions intended for use in conducting chemical or biochemical reactions such as the PCR. Thus, for instance, there is provided a composition for carrying out a chemical or biochemical reaction, said composition being in a freeze-dried form and comprising (i)... Agent: Enigma Diagnostics Ltd
20110244456 - Herbicide tolerant cotton plants and methods for identifying same: The invention provides specific transgenic cotton plants, plant material and seeds, characterized in that these products harbor a specific transformation event at a specific location in the cotton genome. Tools are also provided which allow rapid and unequivocal identification of the event in biological samples.... Agent: Bayer Bioscience N.v.
20110244457 - Immuno-amplification: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte... Agent: Becton, Dickinson And Company
20110244460 - Method for detecting controls for nucleic acid amplification and use thereof: The present invention provides a control detection method for easily detecting a positive control and a negative control simultaneously in one reaction system. An amplification reaction is carried out by adding a control template nucleic acid to a reaction system for detecting controls. The template nucleic acid can be amplified... Agent: Arkray, Inc.
20110244461 - Method for preparing stool sample, solution for preparing stool sample and stool collection kit: The present invention relates to the providing of a method for preparing a stool sample that enables a nucleic acid in a stool to be stably preserved without requiring a complex procedure, a solution for preparing a stool sample, a stool collection kit used in that method, and a method... Agent: Olympus Corporation
20110244458 - Methods and nucleic acids for analyses of cellular proliferative disorders: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of... Agent: Epigenomics Ag
20110244459 - Methods for identifying erbb2 alteration in tumors: Methods for identifying ERBB2 (also named HER2) alteration in tumors, in particular cancer, based on the analysis of the expression of at least three genes of the ERBB2 amplicon located within less than one megabase on either side of ERBB2, and eventually of the gene corresponding to the Affymetrix probeset... Agent: Institut Paoli-calmettes
20110244451 - Methods for prenatal diagnosis of chromosomal abnormalities: Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The invention exploits the differences in DNA between the mother and fetus,... Agent: Trustees Of Boston University
20110244453 - Salmonella detection assay: There is provided a method and reagents for detecting S. enterica subsp. IIIa and/or IIIb in a sample, the method comprising: (a) contacting the sample with a pair of forward and reverse oligonucleotide primers, wherein said forward and reverse primers hybridise to target nucleic acid sequences located within the lacZ... Agent: Health Protection Agency
20110244452 - Sequence data by reduction of noise due to carry-over primer: The present invention provides methods of reducing the background signal of a nucleic acid sequencing reaction. In particular, the invention provides methods of specifically degrading unwanted chain termination reaction products generated by the extension of primers carried over from the amplification step of the sequencing reaction. These methods are amenable... Agent: University Of Washington
20110244464 - Identification of genes or polypeptides the expression of which correlates to fertility, ovarian function and/or fetal/newborn viability: A genetic means of determining whether a female subject produces “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level,... Agent:
20110244463 - Method for columbidae gender identification, nucleotide sequence for columbidae gender and nucleotide primer pair for columbidae gender: The invention provides a method for Columbidae gender identification including: providing a DNA sample of a bird belonging to the Columbidae family; performing a polymerase chain reaction to the DNA sample with a first primer pair of a first primer designed within the region of the SEQ ID. NO.: 9... Agent: Kaohsiung Medical University
20110244462 - Method for estimating telomere length: Knowledge about telomere length is highly relevant in cancer and age related research. Currently applied methods for determining telomere length are subject to several drawbacks preventing fast and reliable information concerning telomere length. The present invention relates to a method for determining telomere length which is fast and reliable. The... Agent: Tina Holding Aps
20110244469 - Method for quantifying initial concentration of nucleic acid from real-time nucleic acid amplification data: Provided is a method for quantifying an initial concentration of a nucleic acid from a real-time nucleic acid amplification data. Nucleic acid (DNA or RNA) extracted from organism or virus is amplified using an enzyme. Then, the initial concentration of the nucleic acid is found by calculating the characteristic amplification... Agent: Samsung Electronics Co., Ltd.
20110244465 - Methods of predicting and monitoring tyrosine kinase inhibitor therapy: The present invention provides methods for analyzing a combination of biomarkers to individualize tyrosine kinase inhibitor therapy in patients who have been diagnosed with cancer. In particular, the assay methods of the present invention are useful for predicting, identifying, or monitoring the response of a tumor, tumor cell, or patient... Agent: Prometheus Laboratories Inc.
20110244467 - Microfluidic apparatus and method for dna extraction, amplification and analysis: An integrated gel based microfluidic sample processing device, suitable for forensic investigations at the scene of a crime, including a substrate having a plurality of micro-channels to form at least a DNA extraction chamber in fluidic cooperation with an amplification chamber which in turn is in fluidic cooperation with a... Agent: University Of Hull
20110244466 - Nucleic acid testing device and method: Devices and systems for extracting, purifying and amplifying nucleic acids, and methods for use of such devices and systems. The devices have top sections which include a plurality of syringe vessels with applicable reagent materials, as well as a channel for a specimen collection dropper. Plungers force the materials sequentially... Agent:
20110244468 - Parallel extraction of different biomolecules from formalin-fixed tissue: The present invention relates to a method of isolating/extracting in parallel various biomolecules, in particular nucleic acids and proteins, from the same fixed biological samples, to the quantification and analysis of the biomolecules isolated by the method of the invention, and to a kit for isolating/extracting in parallel various biomolecules... Agent: Qiagen Gmbh
20110244472 - Cancer stem cell immortalization: The present invention relates to the preparation and use of immortalized cancer stem cells. The immortalized cancer stem cells of the invention may be used in assays to identify anti-cancer compounds as well as molecules critical to carcinogenesis. Further, cancer stem cells may be harvested from a patient and used,... Agent:
20110244470 - Isolated transgenic mammalian neural cell for detection of a sample containing a chemical substance damage to neurological system or selection of drugs for treating neurodegenerative disorders: The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is methods the detection of a sample containing a chemical substance damage to the nervous system and the selection of drugs for treating neurodegenerative disorders.... Agent: Taipei Medical University
20110244471 - Screening method and vector, vector library, and assay kit used therefor: According to one embodiment, a method of screening an enhancer and/or a promoter, includes culturing a host cell into which an amplifiable vector is introduced, extracting the vector from the host cell and obtaining the DNA fragment from the extracted vector, wherein the vector includes a DNA fragment to be... Agent:
20110244473 - Methods and materials for observing apoptosis: The invention provides methods and materials for observing protein fragments generated during apoptosis in order to observe this process in mammalian cells. Embodiments of the invention can be used for example to observe apoptosis in order to examine the sensitivity of a mammalian cancer cell to apoptosis inducing agents.... Agent:
20110244474 - Rapid screening of biologically active nucleases and isolation of nuclease-modified cells: Disclosed herein are methods and compositions for rapidly identifying active nucleases and cells having nuclease-mediated genomic modifications.... Agent: Sangamo Biosciences, Inc.
20110244477 - Antibody-secreting cell assay: An improved assay is described where a surface is provided with immobilized anti-Ig antibodies rather than antigen and where specific antibody-secreting cells (ASC) are detected using soluble antigen probes containing one of several possible labels. The method gives improved sensitivity with less background and is also more representative because antigen... Agent: Mabtech Ab
20110244476 - Method for evaluation of quality of blood sample: A method for evaluating the quality of a blood sample, comprising the steps of: mixing labeled anti-cortisol antibodies with a blood sample to be subjected, to conduct the antigen-antibody reaction of the labeled anti-cortisol antibody with cortisol contained in the blood sample, developing a mixture obtained in the above step... Agent: Kanazawa University
20110244478 - Methods and compositions for treating bleeding disorders: Aspects of the invention include methods for enhancing blood coagulation in a subject. In practicing methods according to certain embodiments, an amount of a non-anticoagulant sulfated polysaccharide (NASP) is administered to a subject to enhance blood coagulation in the subject. Also provided are methods for preparing a NASP composition having... Agent:
20110244475 - Mn gene and protein: Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked... Agent:
20110244479 - Plasmon resonant particles, methods and apparatus: A method and apparatus for interrogating a target having a plurality of plasmon resonant particles (PREs) distributed in the target are disclosed. In the method, a field containing the target is illuminated, and one or more spectral emission characteristics of the light-scattering particles in the field are detected. From this... Agent: The Regents Of The University Of California
20110244485 - Anti-tuna vasa antibody: An object of the present invention is to provide a means for distinguishing between a germ cell derived from a donor (tuna) and a germ cell derived from a recipient in a method for inducing differentiation of a tuna germ cell, wherein a primordial germ cell derived from the tuna... Agent: Nippon Suisan Kaisha, Ltd.
20110244484 - Method of diagnosing alzheimer's disease using giant magnetoresistance sensor and magnetic bead-polyprotein complex for diagnosing alzheimer's disease: Provided are a method of diagnosing Alzheimer's disease using a giant magnetoresistance sensor and a magnetic bead-polyprotein complex for diagnosing Alzheimer's disease. The method of diagnosing Alzheimer's disease using the giant magnetoresistance sensor may be applied to diagnose Alzheimer's disease more easily and simply using the giant magnetoresistance sensor than... Agent: Electronics And Telecommunications Research Institute
20110244486 - Methods and compositions for the diagnosis and treatment of diabetes: Methods, assays and compositions for the diagnosis and treatment of diabetes, in which the glutamate transporters and/or receptors expressed in pancreatic islet cells are used as therapeutic targets or tools for the identification or treatment of individuals suffering from or susceptible to diabetes.... Agent:
20110244487 - Methods for testing binding of a ligand to a g protein-coupled receptor: The present invention relates to methods for testing for the binding of a ligand to a G Protein-Coupled Receptor. In particular, the methods of the invention are useful in high throughput screening for ligands which bind to G Protein-Coupled Receptors.... Agent: Ge Healthcare Uk Limited
20110244480 - method of diagnosis and kit therefor: The invention provides kits and methods for detecting or monitoring the number of cells in sample. The cell comprises a cell surface associated protein (CSAP) comprising a cytoplasmic (cytosolic) and an extracellular (ecto) domain. The kit comprises: (i) a chromatographic device; and (ii) a CSAP-binding agent. The method comprises: (i)... Agent: The Macfarlane Burnet Institute For Medical Research And Public Health Limited
20110244481 - Coelenterazine analogues and coelenteramide analogues: Coelenterazine analogues with different luminescence properties from conventional ones and coelenteramide analogues with different fluorescence properties from conventional ones have been desired. The invention provides coelenterazine analogues modified at the 8-position of coelenterazine and coelenteramide analogues modified at the 2- or 3-position of coelenteramide.... Agent: National University Corporation Tokyo Medical And Dental University
20110244483 - Assessment of protein degradation by measurement of collagen fragments: A method of assay measuring in a biological sample fragments of a protein that contain an N-terminal neo-epitope and a C-terminal neo-epitope, each generated by protease cleavage of said protein, comprises binding the N-terminal neo-epitope with a first specific antibody and binding the C-terminal neo-epitope with a second specific antibody,... Agent: Nordic Bioscience A/s
20110244482 - Assessment of subchondral bone remodelling by measuring cathepsin k fragments of collagen type ii: A method of assay to determine the extent of collagen type II resorption activity comprising measuring the level of fragments of collagen type II that contain a cathepsin K generated neo-epitope not shared by collagen type I by binding the neo-epitope with an antibody specific for the neo-epitope and detecting... Agent: Nordic Bioscience A/s
20110244493 - Cell-based detection of apf through its interaction with ckap4 for diagnosis of interstitial cystitis: An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to... Agent: University Of Florida Research Foundation, Inc.
20110244488 - Chitin-induced immune response based method for diagnosing allergic asthma in patients: A method of diagnosing allergic asthma in patients, including the steps of: obtaining from a subject a first sample of peripheral blood immune cells and a second sample of peripheral blood immune cells; adding chitin to the first sample; measuring the average amount of IFN-γ in both the first sample... Agent:
20110244490 - Detection and monitoring of liver damage: A method of detecting liver damage in a subject comprises measuring the level of caspase-3 generated cytokeratin-18 fragments in the bodily sample. The level of measuring the level of caspase-3 generated cytokeratin-18 fragments is then correlated with liver disease progression.... Agent:
20110244492 - Immunoassays for citrullinated proteins: Methods and kits are provided for assessing radiation injury and exposure in a mammal. The methods comprise the steps of: obtaining one or more test samples from the mammal, contacting the test samples with an antibody immunoreactive with a citrullinated protein to form an immunocomplex; and detecting the immunocomplex with... Agent: Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.
20110244489 - Method for the early detection of renal injury: A method and kit for detecting the immediate or early onset of renal disease and injury, including renal tubular cell injury, utilizing NGAL as an immediate or early on-set biomarker in a sample of blood serum. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected... Agent:
20110244491 - Peptides derived from human bplp protein, polynucleotides coding for said peptides and antibodies directed against said peptides: The invention relates to an in vitro method for prognosis, diagnosis or determination of the evolution of a condition involving an altered production of Basic Proline-rich Lacrimal Protein (BPLP) or of any of its maturation products, by detecting, or quantifying in a biological sample of a test subject, a BPLP... Agent: Institut Pasteur
20110244494 - Reagents, methods and kits for the universal rapid immuno-detection: Novel immuno-detection methods, kits and reagents are provided. The Combination of this invention, combining at least two of the following reagents of a Non-specific Competitor, a Specific Indicator, a primary antibody and an antigen, provides a faster and easier method for an immuno-detection, combining at least two of the following... Agent: Ez Bio Inc.
20110244495 - Method for testing alzheimer's disease by measuring degradation rate of ß-amyloid in blood and diagnostic reagent: Provided is a method of testing Alzheimer's disease using serum or plasma as a sample. It is found that a β-amyloid peptide added to a blood sample is degraded. The degradation activity thereof was compared between the blood samples of normal subjects and Alzheimer's disease patients, and it is also... Agent:
20110244496 - Hiv reverse transcriptase compositions and methods: The present invention provides engineered novel variants of human immunodeficiency virus reverse transcriptase (HIV-RT) capable of being expressed in large quantity and that with polymerase and RNase H activity in a form that facilitates crystallization and high resolution structure resolution following X-ray diffraction. The present invention facilitates high resolution determination... Agent: Rutgers, The State University
20110244497 - Method for judging susceptibility of cancer cells to anthracycline anticancer agent and computer program: The present invention provides a method for judging susceptibility of cancer cells contained in a biological sample to an anthracycline anticancer agent comprising steps of: measuring expression levels of GST-π of cancer cells contained in a biological sample; and judging the susceptibility of cancer cells contained in a biological sample... Agent: Sysmex Corporation
20110244498 - Tyrosine kinase-inducible domains: The present invention relates to a tyrosine kinase-inducible domain (pKID) and uses thereof. An isolated polypeptide comprising the pKID, and an isolated polynucleotide comprising a nucleic acid sequence encoding the pKID are provided. Also provided are methods for determining tyrosine kinase and/or phosphatase activity in a sample and for identifying... Agent: University Of Delaware
20110244499 - Methods of enzymatic hydrolysis: In one embodiment the instant invention generally pertains to a method for producing glucose for fermentation. The method comprises first treating a biomass with acid and heat under conditions sufficient to produce a composition mixture comprising cellulose suitable for enzymatic hydrolysis. Next, at least a portion of the cellulose of... Agent: Texaco Inc.
20110244500 - Gel electrophoresis method useful for resolution and characterization of nerve tissue ultra high molecular weight protein aggregates: The instant disclosure describes an electrophoretic procedure capable of resolving and isolating ultra high molecular weight (MW) protein aggregates from nerve tissue. The procedure is based on the use of composite agarose-polyacrylamide gel electrophoresis (CAPAGE) and resolves proteins and protein aggregates over the range of from approximately 225 kDa to... Agent:
20110244509 - Apoiii and the treatment and diagnosis of diabetes: The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic β cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit... Agent: Biocrine Ab
20110244504 - Biomarkers of inflammation in bruch's membrane of the human retina: A method of diagnosing a patient with age-related macular degeneration (AMD), by detecting biomarkers in the patient's Bruch's membrane, and diagnosing the patient with AMD. A method of detecting the presence of AMD in a patient, by detecting biomarkers in the patient's Bruch's membrane. A method of detecting inflammation in... Agent:
20110244501 - Cancer stem cells: Cancer stem cell populations characterized by expression of CD44hi, ABCG2, β-catenin, CD117, CD133, ALDH, VLA-2, CD166, CD201, IGFR, and/or EGF1R, and methods of isolating and using the same.... Agent: Biogen Idec Ma Inc.
20110244506 - Egfr dependent modulation of chemokine expression and influence on therapy and diagnosis of tumors and side effects thereof: The invention relates to diagnosis and therapy of tumors utilizing the epidermal growth factor (EGFR) by means of chemical inhibitors or monoclonal antibodies. The invention relates also to skin irritations, preferably skin rash, in conjunction and associated with the treatment of tumor cells that utilize EGF receptor with anti-cancer agents.... Agent: Merck Patent Gmbh
20110244502 - Hormone responsive tissue culture system and uses thereof: The invention also provides methods to transform normal primary cells so cultured into “cancer stem cells.” The genetically defined cancer stem cell tumor model mimics the behavior of the disease closely, e.g., the cells are invasive, hormone responsive and metastatic when injected into mice. The tumor cells express genes that... Agent: Whitehead Institute For Biomedical Research
20110244505 - Method for in vitro blood testing: Method for determining the presence of a malady in a patient by measuring the degree of reaction of individual types of white blood cells (basophils, eosinophils, neutrophils, monocytes and lymphocytes) in the patient's blood. The degree of reaction of each type of white blood cells is determined by comparing the... Agent: Signet Diagnostic Corporation
20110244508 - Method for investigating the thrombocyte function of the blood: A method for investigating the thrombocyte function of the blood, and particularly of platelet aggregation, wherein the following steps are carried out: a) cross-flowing an aperture with blood or blood components; b) determining the active radius of the aperture depending on time and c) evaluating the time-dependent modification of the... Agent:
20110244503 - System and method for anti-cancer drug candidate evaluation: The disclosure provides a method of evaluating the ability of an anti-cancer drug candidate to induce apoptosis in a known cancer cell line by placing a single-cell suspension of a known cancer cell line in a well of a plate, adding at least one drug candidate to the well in... Agent:
20110244507 - Use of neuregulin-ß as an indicator and/or target: The invention furthermore relates to the use of neuregulins, preferably a neuregulin isoform having an isoelectric point in the range from pH 4.3 to 5.0, as a target for detecting and/or exerting an influence on neuronal processes, in particular for exerting an influence on long-term memory. Neuregulins, in particular neuregulin-β... Agent: Mind-nrg Sa
20110244510 - Filtration method for detecting microbial contamination: Disclosed is a convenient sample preparation method for a medium suspected of containing contaminants, the method comprising a) passing a known volume of said medium through a filter from an influent side to an effluent side thereby concentrating the contaminants on the influent side of the filter, b) contacting the... Agent:
20110244511 - Methods and articles for detecting hemolytic microorganisms: A thin film culture plate device useful for detecting hemolysin-producing microorganisms is included. The device can further include selective agents and/or indicators to differentiate groups or species microorganisms. Methods of use include detecting or enumerating hemolysin-producing microorganisms.... Agent: 3m Innovative Properties Company
20110244512 - Pentose phosphate pathway upregulation to increase production of non-native products of interest in transgenic microorganisms: Coordinately regulated over-expression of the genes encoding glucose 6-phosphate dehydrogenase [“G6PDH”] and 6-phospho-gluconolactonase [“6PGL”] in transgenic strains of the oleaginous yeast, Yarrowia lipolytica, comprising a functional polyunsaturated fatty acid [“PUFA”] biosynthetic pathway, resulted in increased production of PUFAs and increased total lipid content in the Yarrowia cells. This is achieved... Agent: E. I. Du Pont De Nemours And Company
20110244513 - Isolated mammalian membrane protein genes; related reagents: Nucleic acids encoding various lymphocyte cell proteins from mammalian, including primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.... Agent: Schering Corp.
20110244514 - Mammalian sweet taste receptors: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of... Agent:
20110244515 - Method of preparing protein having high content of specific amino acid by co-expression with trna of specific amino acid: The present invention relates to a method of increasing the expression of a target protein by co-expression of a gene encoding a target protein having a high content of a specific amino acid with a nucleotide sequence encoding the tRNA of the specific amino acid. According to the present invention,... Agent:
20110244516 - Rage fusion proteins and methods of use: Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity... Agent:
20110244517 - System for antibody expression and assembly: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can... Agent:
20110244518 - Prokaryotic expression of soluble, active dkk: Dickkopf (Dkk) proteins inhibit the canonical Wnt signaling pathway. Each of the members of the Dkk family has been previously cloned and expressed as a soluble protein in eukaryotic cells, while expression in bacterial cells has resulted in the formation of insoluble inclusion bodies that require further processing. The present... Agent:
20110244519 - Use of rna trans-splicing for antibody gene transfer and antibody polypeptide production: The present invention provides methods and compositions for generating novel nucleic acid molecules through RNA trans-splicing that target a highly expressed pre-mRNA and contain the coding sequence for antibody polypeptide(s). The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with the target precursor messenger RNA molecule (target... Agent: Virxsys Corporation
20110244520 - Compositions and methods for bacterial production of chondroitin: The invention relates to the field of recombinant DNA technology for the production of chondroitin, including the production of chondroitin sulfate via a combination of recombinant bacterial fermentation and post-fermentation sulfation.... Agent:
20110244521 - Method for preparation of recobinant dna: The above problem can be solved with the present method for preparing a recombinant DNA by inserting a DNA fragment of interest into a vector DNA, the method comprising the step of carrying out the following reactions at the same reacting location at the substantially simultaneouse time: (a) a reaction... Agent:
20110244522 - Rotational pcr equipment and pcr method using the same: The disclosed rotational PCP apparatus includes: a PCR chip where PCR is performed; a rotating means connected to the PCR chip and rotating the PCR chip; and a temperature zone forming means spaced apart from the PCR chip, capable of applying thermal energy to the PCR chip and allowing the... Agent:
20110244523 - Modified rna ligase for efficient 3` modification of rna: The invention provides a novel truncated mutated T4 RNA ligase 2. In addition, methods are provided for ligating pre-adenlylated donor molecules to the 3′ hydroxyl group of RNA in the absence of ATP using the ligase.... Agent: The Rockefeller University
20110244524 - Cell-free system for synthesizing membrane proteins cell free method for synthesizing membrane proteins: The invention provides an in vitro method for producing proteins, membrane proteins, membrane-associated proteins, and soluble proteins that interact with membrane-associated proteins for assembly into an oligomeric complex or that require association with a membrane for proper folding. The method comprises, supplying intracytoplasmic membranes from organisms; modifying protein composition of... Agent:
20110244525 - Microorganism expressing xylose isomerase: The present invention relates to a transformed microorganism capable of (a) a higher xylose isomerase activity than the equivalent microorganism prior to transformation; and/or (b) a higher growth rate in or on a growth medium comprising xylose than the equivalent microorganism prior to transformation; and/or (c) a faster metabolism of... Agent: Terranol A/s
20110244526 - Alpha-amylase blends and methods for using said blends: The present invention relates to an alpha-amylase blend, including a B. stearothermophilus alpha-amylase (AmyS) wherein the amino acid at position S242 is substituted and a B. licheniformis alpha-amylase blends for starch liquefaction and saccharification, ethanol production, and a sweetener production.... Agent: Danisco US Inc.
20110244527 - Method for producing b-glucanase and xylanase, and liquid culture medium: A method for producing β-glucanase and xylanase which includes the step of culturing a microorganism classified under the genus Trichoderma using a liquid culture medium which contains (a) a pulp derived from paper which has not been subjected to heat treatment nor alkali treatment as a carbon source, and (b)... Agent: Asahi Breweries, Ltd.
20110244528 - Process for producing useful substance: The present invention provides a process for efficiently producing a useful substance; and a microorganism which belongs to coryneform bacteria and which can be used in the process. The present invention provides a process for producing a useful substance by using a microorganism belonging to coryneform bacteria, the microorganism having... Agent: Kyowa Hakko Bio Co., Ltd.
20110244529 - Process for the fermentative preparation of l -ornithine: A process for the fermentative preparation of L-ornithine using microorganisms characterized by an increased export of the amino acid.... Agent: Evonik Degussa Gmbh
20110244530 - L-succinylaminoacylase and process for producing l-amino acid using it: A protein which is characterized in being represented by any of the following (a) to (d): (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2;... Agent: Sekisui Medical Co., Ltd.
20110244531 - Synthesis routes to 2(s),4(s),5(s),7(s)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides: The invention relates to a process for the preparation of compounds that are important building blocks in convergent synthesis routes to 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides or pharmaceutically acceptable salts thereof, such as the compound Aliskiren, and to a process for the preparation of these octanoyl amides, comprising reacting said building block.... Agent:
20110244532 - Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells: Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of making branched fatty acid derivatives using the recombinant microbial cells.... Agent: Ls9, Inc.
20110244533 - Fibrous materials and composites: Fibrous materials, compositions that include fibrous materials, and uses of the fibrous materials and compositions are disclosed. For example, the fibrous materials can be operated on by a microorganism to produce ethanol or a by-product, such as a protein or lignin.... Agent: Xyleco, Inc.
20110244534 - Process for the preparation of a monovalent succinate salt: b
20110244536 - Fermentive production of isobutanol using highly effective ketol-acid reductoisomerase enzymes: Ketol-acid reductoisomerase enzymes have been identified that provide high effectiveness in vivo as a step in an isobutanol biosynthetic pathway in bacteria and in yeast. These KARIs are members of a clade identified through molecular phylogenetic analysis called the SLSL Clade.... Agent: Butamax(tm) Advanced Biofuels LLC
20110244535 - Production of peracids using an enzyme having perhydrolysis activity: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family... Agent:
20110244537 - Regio- and enantioselective alkane hydroxylation with modified cytochrome p450: Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively using atmospheric dioxygen as an oxidant. Mutant 9-10A-A328V hydroxylates octane primarily at the 2-position to form S-2-octanol (40% ee). Another mutant, 1-12G, hydroxylates alkanes larger than... Agent: The California Institute Of Technology
20110244538 - Fermentation of gaseous substrates: The invention relates to the microbial fermentation of gaseous substrates, particularly to gas/liquid contact modules and bioreactors configured to improve the efficiency of fermentations, particularly microbial fermentations of substrates comprising CO. In a particular embodiment, a gas/liquid contact module with multiple channels is configured to produce products in a liquid... Agent:
20110244539 - Selection of cellulolytic microbes with high growth rates: Methods for obtaining cellulolytic microbes with high growth rates are disclosed. For example, C. thermocellum colonies with growth rates higher than 0.17 hr″ 1 have been obtained by the present methods. In realizing higher growth rates, better bioprocessing efficiency can be achieved resulting in increased economy.... Agent: The Trustees Of Dartmouth College
20110244541 - Bioaugmentation of anaerobic digester systems: Disclosed herein are methods for improving performance of an anaerobic digester system. The methods typically include adding a culture comprising hydrogenotrophic methanogens to the system, otherwise referred to as bioaugmentation.... Agent: Marquette University
20110244540 - Preservation of methanogenic, hydrogen-utilizing microbial cultures: Disclosed are drying methods for preserving cultures of methanogens and dried cultures obtained by the disclosed drying methods. The dried cultures of methanogens may be reconstituted and utilized to bioaugment anaerobic digester systems.... Agent: Marquette University
20110244542 - Clostridium sporosphaeroides for the treatment of biomass: A method of treatment of biomass is described, characterized in that a microorganism of the species Clostridium sporosphaeroides is added to the biomass.... Agent:
20110244543 - U-shape and/or nozzle u-loop fermenter and method of fermentation: A fermenter and a method of fermentation in a U-shape and/or nozzle U-loop fermenter (100) comprising a U-part having an essentially vertical down-flow part (101), an essentially vertical up-flow part (102) and a substantially horizontal connecting part (103), which connects the lower ends of the down-flow part (101) and the... Agent:
20110244546 - Internalizing anti-cd74 antibodies and methods of use: The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, which is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies, other malignancies in which... Agent: Immunomedics, Inc.
20110244544 - Polymeric carriers for immunohistochemistry and in situ hybridization: Certain disclosed embodiments of the present invention concern the synthesis, derivatization, conjugation to immunoglobulins and signal amplification based on discrete, relatively short polymers having plural reactive functional groups that react with plural molecules of interest. Reactive functional groups, such as hydrazides, may be derivatized with a variety of detectable labels,... Agent: Ventana Medical Systems, Inc.
20110244545 - Polymeric carriers for immunohistochemistry and in situ hybridization: Certain disclosed embodiments of the present invention concern the synthesis, derivatization, conjugation to immunoglobulins and signal amplification based on discrete, relatively short polymers having plural reactive functional groups that react with plural molecules of interest. Reactive functional groups, such as hydrazides, may be derivatized with a variety of detectable labels,... Agent: Ventana Medical Systems, Inc.
20110244547 - Sulfotransferase 1e1 sequence variants: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described.... Agent: Mayo Foundation For Medical Education And Research
20110244548 - Dna polymerases having improved labeled nucleotide incorporation properties: The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one mutation in the nucleotide label interaction region of the enzyme such the mutation results in reduced discrimination against labeled nucleotides. The nucleotide label... Agent: Life Technologies Corporation
20110244551 - Extract having protease activity: The present invention discloses a composition comprising a proteinaceous extract of Streblus asper having substantially protease activity that degrades proteins by hydrolysis of peptide bonds. The proteinaceous extract of Streblus asper according to the present invention is suitable for us as a meat quality-improving agent and a milk coagulant in... Agent: Universiti Putra Malaysia
20110244550 - Factor ix polypeptide mutant, its uses and a method for its production: Disclosed are a modified FIX (factor IX) polypeptide comprising a leucine, cysteine, aspartic acid, glutamic acid, histidine, lysine, asparagine, glutamine or tyrosine in position 338; pharmaceutical preparations containing said modified FIX polypeptide; a nucleotide sequence coding for the modified FIX polypeptide; and a method for producing the modified FIX polypeptide.... Agent:
20110244549 - Hepatitis c virus variants: The present invention relates to HCV variants, particularly variants that are resistant to a protease inhibitors such as VX-950. Also provided are methods and compositions related to the HCV variants. Further provided are methods of isolating, identifying, and characterizing multiple viral variants from a patient.... Agent: Vertex Pharmaceuticals Incorporated
20110244552 - Methods and compositions for the production of recombinant virus vectors: A method for the production of a replication-deficient recombinant virus vector is disclosed. The replication-deficient recombinant virus vector has a recombinant virus genome with one or more defective viral genes. The method comprises infecting a host cell with a carrier virus having a carrier virus genome encoding one or more... Agent:
20110244553 - Biofuel production: Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity... Agent: Bio Architecture Lab, Inc.
20110244554 - Mechanical device for dispersing biomass populations: A biomass dispersing system and method that breaks up biomass aggregates is disclosed. The system is designed to avoid cell damage and loss of cell viability while dispersing biomass aggregates for applications where biomass aggregates can cause operation problems. The dispersed biomass suspension obtained using the disclosed system will not... Agent: E. I. Du Pont De Nemours And Company
20110244555 - Method and system for purifying raw gases, particularly biogas, for obtaining methane: In a method for purifying biogas, components present in the biogas, such as carbon dioxide, sulfur compounds and ammonia, are separated in a plurality of different process stages. The method is characterized by low energy consumption and an increase in methane concentration of at least 10% while keeping methane losses... Agent: Dge Dr.-ing. Guenther Engineering Gmbh
20110244556 - process for preparing ganoderma spore oil: The present invention relates to a method for preparing Ganoderma spore oil which is in the field of biotechnology. The method includes using Ganoderma spore powder and Ganoderma powder (obtained from grinding fruiting bodies) as raw materials, applying enzymatic Ganoderma sporoderm broken methods, one-step granulation, supercritical CO2 extraction method, as... Agent:
20110244557 - Sample analyzer and non-transitory storage medium: A sample analyzer comprising: a container set section in which a reagent container can be set which contains a reagent to be used in a sample analysis; a cover capable of making the container set section be in an open state and a closed state; a locking mechanism capable of... Agent:
20110244558 - Sample analyzer and information writing method: A sample analyzer comprising: a reagent container set section for setting a reagent container; a reader/writer configured to read out an information from the recording medium attached to the reagent container set in the reagent container set section and configured to write an information on the recording medium; a writing... Agent:
20110244559 - Fabrication method of microfluidic circuit, and microfluidic circuit fabricated by method thereof: A fabrication method of a microfluidic circuit is provided, dispensable of mask registration, absent of deviation in mask positioning, and inexpensive in fabrication cost. The fabrication method of a microfluidic circuit has a light transmissive substrate stacked on a light absorptive substrate, and the light transmissive substrate welded with the... Agent: Rohm Co., Ltd.
20110244560 - Composting apparatus: A composting apparatus comprising a container for receiving material to be composted a base member in the apparatus for supporting material to be composted and the compost when formed, the base having a curved lower wall and an upper opening to define a volume for receiving a drainage medium, a... Agent: Global Environment Management (fzc)
20110244563 - Assays that use the t1r1 receptor polypeptides to screen for t1r1-associated taste modulators: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent:
20110244564 - Cystine knot molecules: The present invention relates generally to a molecular framework having a cyclic structure. More particularly, the present invention provides cyclic proteins and derivatives thereof in which particular turns and other elements of the molecular structure are held in defined orientations with respect to each other. The cyclic proteins of the... Agent: The University Of Queensland
20110244562 - Rna interference suppression of neurodegenerative diseases and methods of use thereof: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules.... Agent: University Of Iowa Research Foundation
20110244561 - Sirna-mediated gene silencing: The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.... Agent: University Of Iowa Research Foundation
20110244566 - Enhanced efficiency of induced pluripotent stem cell generation: Human somatic cells are reprogrammed to become induced pluripotent stem cells (iPS cells) by the introduction of a minicircle DNA vector. Cells of interest include adipose stem cells.... Agent:
20110244565 - Method of collecting particles from a sample fluid: A method is provided for collecting a concentration of particles from a sample fluid containing the particles. The method includes the steps of providing a microfluidic device. The microfluidic device includes an input channel, an output channel and a collection region. The input channel has an input end and an... Agent:
20110244567 - Device and method of 3-dimensionally generating in vitro blood vessels: Provided herein are apparatuses, systems and methods for generating concentration gradients of soluble molecules. Also, provided herein devices and methods for generating in vitro blood vessels.... Agent: Snu R&db Foundation
20110244569 - Method of inducing proliferation and/or differentiation of neural precursor cells by introducing prolactin or wnt3a to activate latent neural precursor cells: A method of inducing proliferation and/or differentiation of a hippocampal cell population activating a latent neural precursor cell, enriching a cell population for neural precursor cells and treating neurodegenerative diseases and/or repopulating a damaged hippocampus by introducing prolactin or Wnt3a so as to activate a latent neural precursor cell population.... Agent:
20110244568 - Rna sequence-specific mediators of rna interference: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long... Agent:
20110244570 - Volume exclusion agent to enhance formation of extracellular matrix: A method of enhancing the formation of extracellular matrix in culture. Cells in culture secrete most of the collagen into the media as unprocessed procollagen, i.e., the cells do not convert procollagen to collagen. In contrast, normal extracellular matrix deposition involves procollagen processing to collagen, fibril assembly and deposition into... Agent: Thomas Jefferson University
20110244571 - Cell growth: Methods of preparing pre-engineered surfaces using various nanolithography techniques to generate, isolate, and multiply homogeneous cell populations. Surfaces can be treated by etching before exposure to biological systems like cells. Stem cell applications are described.... Agent: Nanolnk, Inc.
20110244572 - Flat microfibers as matrices for cell growth: The present invention relates to culturing cells utilizing a matrix of microfibrillated thermoplastic polymeric materials. More specifically, the present invention relates to a method of culturing cells. In addition, the invention relates to a microfibrillated article for culturing cells dispersed in a cell culture medium. The matrix of thermoplastic polymeric... Agent: 3m Innovative Properties Company
20110244573 - Method for the supply of growth components to cell cultures: The present invention provides a method for improving the preparation and use of growth media by the uses of specific pellet formulations, which especially are tablets of different sizes, which contain the growth medium or parts thereof and are sterilized with the standard methods of pharmaceutical technology. Specifically these pellet... Agent: Biosilta Oy
20110244574 - Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (mva): The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA... Agent:
20110244575 - Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-hp): The present invention relates to methods, systems and compositions, including genetically modified microorganisms, adapted to exhibit increased tolerance to 3-hydroxypropionic acid (3-HP), particularly through alterations to interrelated metabolic pathways identified herein as the 3-HP toleragenic pathway complex (“3HPTGC”). In various embodiments these organisms are genetically modified so that an increased... Agent:
20110244576 - Herpes simplex virus complex: There is provided an HSV complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an... Agent: Crusade Laboratories LimitedPrevious industry: Education and demonstration
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