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Chemistry: molecular biology and microbiology September class, title,number 09/11

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
09/29/2011 > 106 patent applications in 64 patent subcategories. class, title,number

20110236874 - Method for formation of renal tubules: There is provided a method of making a renal tubule. The method comprises seeding renal tubule cells onto a solid surface; culturing the renal tubule cells in a liquid growth medium to form a monolayer on the solid surface; and continuing culturing the renal tubule cells to form a tubule.... Agent:

20110236875 - Composition and method for the restoration and preservation of transplant organs procured from dcd donors: The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with... Agent: University Of North Carolina At Charlotte

20110236876 - Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light: A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the... Agent: Caridianbct Biotechnologies, LLC

20110236877 - Biosensor and method using the same to perform a biotest: The present invention discloses a biosensor and a method using the same to perform a biotest. The biosensor of the present invention integrates a SAW (Surface Acoustic Wave) device and a test polymer to detect an analyte in a liquid specimen. The test polymer reacts with the analyte. After reaction,... Agent:

20110236878 - Rapid characterization of proteins in complex biological fluids: Disclosed herein are compositions and methods for the rapid screening of candidate protein therapeutics. In particular, the instant invention provides compositions and methods for assaying the behavior of candidate protein therapeutics in complex biological fluids and for identifying those candidate protein therapeutics exhibiting desirable pharmacokinetic properties in such fluids.... Agent:

20110236883 - Detection of herpes simplex virus types 1 and 2 by nucleic acid amplification: The present invention relates to a method of detecting the presence or absence of herpes simplex virus (HSV) in a sample based on amplifying a portion of the Glycoprotein G(US4) gene of HSV and detecting the presence of the amplified nucleic acid using primers and detector primers as described herewith.... Agent: Becton, Dickinson And Company

20110236879 - Methods and compositions for analyte detection: The present invention is directed to methods and apparatus for detection of one or more analytes. Analytes include agents or components of infectious agents such as pathogenic virus, as well as enzymes, proteins and biomarkers.... Agent: Nexus, Dx, Inc.

20110236884 - Microbubbles for affinity separation: The present invention relates to methods, compositions and kits for affinity isolation, affinity purification and affinity assay based on microbubbles coated with an affinity molecule. Particularly, the invention provides protein microbubbles coated with an affinity molecule. In addition, the invention provides glass microbubbles coated with an affinity molecule. Methods of... Agent:

20110236881 - Modulation of influenza virus: The present invention provides, among other things, methods for the identification of compounds that are capable of modulating the activity of the influenza A virus. For example, the present methods provide platforms for identifying small molecule inhibitors that target the proton transport pathway defined at least in part by two... Agent:

20110236880 - Potentiated biocidal compositions and methods of use: The present technology relates to biocidal compositions and methods that contain and utilize at least one biocidal agent and at least one potentiator system wherein the resultant combination has an enhanced biocidal efficacy. The present technology also discloses a rapid screening assay for determining biocidal compositions with enhanced efficacy, e.g.,... Agent:

20110236882 - Quantitative measurement of nano/micro particle endocytosis with cell mass spectrometry: Methods for detecting the presence of nanoparticles or microparticles by cell mass spectrometry (CMS) are provided. CMS methods are provided for determining the number of nanoparticles or microparticles in each cell. Nanoparticles whose intracellular concentration can be determines by the CMS methods of the invention include polymeric nanoparticles (NPs), liposomes,... Agent: Academia Sinica

20110236885 - Genetic variants predicting warfarin sensitivity: We discovered that a polymorphism in the promoter of the VKORC1 gene is associated with warfarin sensitivity. This polymorphism can explain both the inter-individual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORC1 gene... Agent: Academia Sinica

20110236888 - Method for accessing the contents of a closed vessel containing a specimen retrieval device: Method for obtaining a fluid from a collection device assembled to isolate a specimen retrieval device from the pathway of a fluid transfer device used to penetrate a cap of the collection device and to draw and remove the fluid from the collection device for analysis.... Agent: Gen-probe Incorporated

20110236889 - Methods of screening for compounds for use as modulators of left-right asymmetry in scoliotic subjects and for monitoring efficacy of an orthopaedic device: A method of screening for a compound for treating or preventing adolescent idiopathic scoliosis (AIS), said method comprising: (a) contacting a test compound with a paraspinal skin fibroblast or a paraspinal muscle cell sample from the right and/or left side of the spine of a subject; and (b) determining at... Agent:

20110236887 - Modified actinomycin-based nucleic acid stains and methods of their use: Actinomycin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided.... Agent: Life Techologies Corporation

20110236886 - Pathogenicity determinants which can be used as targets for developing means for preventing and controlling bacterial infections and/or systemic dissemination: The invention relates to a method for identifying and selecting a gene required for the proliferation in vivo of a pathogenic microorganism, comprising:—using a strain of the pathogenic microorganism,—generating mutants for inactivation in the genes encoding these factors,—determining the virulence of these mutants on an experimental model of infection, and... Agent:

20110236893 - Lgr5 modulators in the treatment of alopecia: An in vitro method of screening for candidate compounds for the preventive or curative treatment of alopecia, which comprises determining the ability of a compound to modulate the expression or the activity of the LGR5 receptor is described. The use of modulators of the expression or of the activity of... Agent: Galderma Research & Development

20110236892 - Method for lowering the dependency towards sequence variation of a nucleic acid target in a diagnostic hybridization assay: A primer or/and probe for a target sequence containing at least one variation, defined as either one non-conserved nucleotide, called genotype variation, or one nucleotide variation within one and the same genotype, wherein the primer or/and probe has a nucleic acid sequence that is complementary to said target sequence except... Agent: Biomerieux

20110236895 - Method for preparing sample, solution for preparing sample and stool collection kit method for analyzing a nucleic acid: The present invention relates to the providing of a method for preparing a sample from a nucleic acid-containing sample such as biological samples, where inhibitory substance's action against a enzyme reaction using a nucleic acid as substrate are decreased, a solution for preparing a sample used for the method, a... Agent: Olympus Corporation

20110236890 - Method of screening for cancer by detecting mutations in the delta-catenin gene promoter and 5'-untranslated region: A method for screening for risk of cancer in a subject is carried out by detecting the presence or absence of at least one mutation in the delta-catenin gene promoter or 5′ untranslated region in a biological sample from said subject, the presence of such mutation or an increased frequency... Agent:

20110236891 - Nucleic acid template preparation for real-time pcr: The invention teaches a novel reagent formulation for the efficient preparation of a nucleic acid template from cells for high throughput real-time PCR analysis. The reagent permits rapid cell lysis and template preparation without the need for template purification and isolation. The reagent therefore dramatically improves throughput of real-time PCR... Agent: Samsung Techwin Co., Ltd.

20110236896 - Rgs2 genotypes associated with extrapyramidal symptoms induced by antipsychotic medication: The present invention identifies genotypes associated with resistance to extrapyramidal symptoms induced by antipsychotic drugs. The present invention further identifies genotypes associated with predisposition to the onset or aggravation of extrapyramidal symptoms induced by antipsychotic drugs and use thereof for assessment of patient populations. Specifically, the present invention relates to... Agent: Hadasit Medical Research Services And Development Ltd.

20110236894 - Selective oxidation of 5-methylcytosine by tet-family proteins: The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes... Agent: Immune Disease Institute, Inc.

20110236899 - Method and apparatus for predicting pharmaceutical efficacy of anti-tnfa antibody drug against rheumatoid arthritis: A method for predicting a pharmaceutical efficacy of an anti-TNFα antibody drug against rheumatoid arthritis, the method including measuring an amount of ADAMTS5 contained in a sample derived from a subject, and determining whether or not the anti-TNFα antibody drug is efficient against rheumatoid arthritis by employing the amount of... Agent:

20110236898 - Methods for enhancing nucleic acid hybridization: m

20110236897 - Novel markers for diagnosing brain disease caused by brain injury and use thereof: The present invention relates to novel markers for diagnosing brain disease caused by brain injury and the use thereof. More particularly, the present invention relates to novel diagnostic markers for brain disease caused by brain injury, which are identified by administering an MDMA drug, a diagnostic composition for brain disease... Agent:

20110236900 - Novel muts protein and method for determing mutation using the same: A method for determining the presence or absence of a mutation on the basis of the presence or absence of amplification with high reliability is provided. A target sequence including a target site contained in a sample nucleic acid is amplified using a primer that can hybridize to a region... Agent: Kabushiki Kaisha Dnaform

20110236901 - Thermal cycling system comprising transport heater: To provide a thermal cycling system allowing an efficient thermal cycling and an optical detection during the diagnostic process a thermal cycling system is proposed, comprising: at least one heating device (10a, 10b) having a transparent substrate (11a, 11b) and a heating element (12a, 12b), and a chamber (30) adapted... Agent:

20110236902 - Testing a patient population having a cardiovascular condition for drug efficacy: Lumenectomy material is tested to determine the efficacy of a test drug in a patient population having a cardiovascular condition. The material is removed from at least a first and a second patient and tested for one or more markers of a cardiovascular condition. The first patient is administered the... Agent: Tyco Healthcare Group Lp

20110236903 - Materials and methods for determining diagnosis and prognosis of prostate cancer: Materials and Methods related to diagnosing and/or determining prognosis of prostate cancer.... Agent:

20110236904 - Detection of tumor stem cells and tumor cells in epithelial-mesenchymal transition in body fluids of cancer patients: According to the present invention said method comprises a selecting step for selection or enrichment of said predetermined cells from the sample wherein the sample is contacted with the solid surface for preferential binding of said predetermined cells to the solid surface and then the sample is removed from the... Agent: Adnagen Ag

20110236905 - Method for screening cattle, cattle screened, and cattle screening kit: The method for screening individual cattle according to the present invention includes the steps of (1) harvesting body tissue from the cattle, (2) extracting the full complement of proteins from the body tissue harvested, (3) detecting a wild-type annexin A5 protein, an isoform of the wild-type annexin A5 protein, or... Agent:

20110236906 - Secretory protein biomarkers for high efficiency protein expression: The instant invention relates to the field of protein production, and in particular is relates to compositions and processes for improving the production levels of recombinant proteins expressed in host cells.... Agent:

20110236907 - Radiolabled cyclopamine assay for the smoothened receptor: The present invention discloses novel methods for screening compositions for both agonist and antagonist activity on the smoothened receptor. The assay tests ligands on the activity of the receptor using a cyclopamine binding and ultra high receptor expression.... Agent:

20110236909 - Laser scanning cytometry mediated analysis of therapeutic efficacy in tumors: This invention describes the use of a laser scanning device, for example a laser scanning CYTOMETRY (LSC), with a double-fluorescent labeling technique as a quantitative method that can be used to objectively and accurately measure endothelial cell death, endothelial tumor cell death and blood vessel density of tumor tissue. These... Agent:

20110236910 - Prostate cancer biomarker: The present invention relates to the field of prostate cancer. Particularly the invention relates to villin as a novel prostate biomarker. The invention further relates to compositions comprising anti-villin antibodies and use of these compositions for an improved detection of prostate cancer in a subject.... Agent:

20110236908 - Total plasma fvii/fviia levels as indicators of pre-eclampsia of pregnant females: Raised total plasma FVII protein, including activated FVII (FVIIa) in pregnant females, compared with total plasma FVII protein in normal pregnancy, has been found to be an indicator of the pregnancy complication of pre-eclampsia.... Agent: University Of Southampton

20110236911 - Precipitating substrate for bio-layer interferometry: Improved apparatus, compositions, and methods for carrying out interferometry-based assays for detecting analytes in a sample through the use of a precipitating substrate to enhance an interferometry binding signal, and kits useful for carrying out these assays. Methods comprise providing an optical assembly comprising an optical element with a transparent... Agent: Fortebio, Inc.

20110236913 - Compostion and kit for diagnosing immunoglobulin a nephropathy and tgbm nephropathy: Disclosed is the development of a protein used as a biomarker for diagnosing IgA nephropathy and TGBM (thin-glomerular-basement-membrane) using urine through a target proteomics method. The disclosed development relates to a diagnosis biomarker protein and a kit for diagnosing IgA nephropathy and TGBM and predicting progress of the nephropathy in... Agent: Kyungpook National University Industry-academic Cooperation Foundation

20110236914 - Recording assay device: A method for assaying a sample involves an assessment device having an assay part and a detachable recording part, which are disposed on separable portions of a substrate. The sample to be assayed is received in a sample application well on the assay element, where it contacts a measuring element,... Agent: Smartsensor Telemed Ltd.

20110236912 - Systems and methods for characterizing lupus erythematosus: The present invention provides systems and methods for characterizing biological markers in the urine of systemic lupus erythematosus (SLE) subjects. In particular, the present invention relates to the detection of cytokines and chemokines in urine of SLE subjects for determining nephritic disease states and kidney damage in SLE subjects and... Agent: Renovar, Inc.

20110236915 - Zap-70 expression as a marker for chronic lymphocytic leukemia / small lymphocytic lymphoma (cll/sll): It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA... Agent: The Government Of Usa As Represented By The Secretary Of The Dep't Of Health And Human Service

20110236916 - Methods and materials for detecting colorectal neoplasm: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA,... Agent: Mayo Foundation For Medical Education And Research

20110236917 - Diagnosis of alzheimer's disease: Embodiments of an assay for the screening, diagnosis, and differentiation of Alzheimer's disease uses selected sets of serum protein biomarkers. The assay is used to distinguish Alzheimer's disease from Parkinson's disease, other neurodegenerative diseases, and normal controls. Specific sets of serum protein biomarkers are identified for the diagnosis of Alzheimer's... Agent: Power3 Medical Products, Inc.

20110236918 - Methods for conducting genetic analysis using protein polymorphisms: Methods and processes for conducting genetic analysis through protein polymorphisms, including identification of individuals, establishment of paternity and measurement of genetic diversity and distance. Some illustrative embodiments of methods of the present invention include the identification of peptide biomarkers using proteomic techniques, including liquid chromatography-tandem mass spectrometry from biological samples,... Agent:

20110236920 - Novel variants of pqq-dependent glucose dehydrogenase having improved substrate specificity: The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) which have an increased substrate specificity compared with the wild type, and also to methods for production and identification thereof.... Agent:

20110236919 - Process for restricting carbon monoxide dissolution in a syngas fermentation: A process to temporarily and selectively control the dissolved concentration of CO in the feed medium portion of a fermentation liquid by addition of a surface tension active compound (STAC), particularly during seed train scale-up operations and during recovery from process upsets, to support improved production of biofuels from a... Agent:

20110236921 - Cell system: The present invention relates to cellular systems for testing drug candidates and for evaluating the function of mitochondrial proteins. The invention is particularly useful for evaluating drug candidates for cancer and for conducting studies on drug resistance.... Agent: Ge Healthcare Uk Limited

20110236922 - Method to determine state of a cell exchanging metabolites with a fluid medium by analyzing the metabolites in the fluid medium: The present invention relates to a method for determining the ideal time for and outcome of reproductive health procedures including in vitro fertilization by establishing a correlation between the successful outcome of said procedure and the spectra of a body fluid obtained using a chosen analytical modality for a population... Agent: Mcgill University

20110236923 - Method for staining and sorting of a small volume of sperm: The present invention relates to a method of sorting of a small volume or low concentration stained sperm sample, the method includes: (a) diluting the stained sperm cells in a ratio of 1:1 or less by volume with a dilution buffer to obtain a diluted volume of said stained sperm... Agent: Genetics & Ivf Institute

20110236924 - System and method for processing samples: A system and method for processing samples. The system can include a loading chamber, a detection chamber positioned in fluid communication with the loading chamber, and a fluid path defined at least partially by the loading chamber and the detection chamber. The system can further include a filter positioned such... Agent:

20110236926 - Host cells and methods of producing disulfide bond containing proteins: The invention provides for genetically modified Bacillus host cells having decreased cytoplasmic reductase activity, such as decreased TrxA activity, and a nucleic acid encoding a heterologous Staphylococcal oxidase. The invention also provides for methods of producing di-sulfide bond containing proteins using the host cells of the invention and methods of... Agent:

20110236925 - Method of obtaining a purified, biologically active heterologous protein: The invention relates to methods of separation and/or purification of impurities yielding a purified heterologous protein product devoid of related impurities or with substantially minimal quantities of such glycosylated impurities. More specifically, the invention relates to the identification of glycosylated forms of insulin analogues such as glargine impurities characterized post... Agent: Biocon Limited

20110236927 - Genetically stabilized tandem gene duplication: The invention provides constructs and methods for producing genetically stabilized tandem gene duplications.... Agent: Massachusetts Institute Of Technology

20110236928 - Methods for producing polypeptides in enzyme-deficient mutants of fusarium venenatum: The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a parent Fusarium venenatum strain in a medium for the production of the polypeptide, wherein the mutant strain comprises a polynucleotide encoding the polypeptide and one or more (several) genes selected from the group... Agent: Novozymes, Inc

20110236929 - E. coli bl21 strain lacking a functional group ii capsular gene cluster: The present invention relates to a novel non-pathogenic Escherichia coli (E. coli) B BL21 strain comprising a deletion of group II capsular gene cluster, and the use thereof for the production of peptides.... Agent: Novo Nordisk A/s

20110236930 - Chemoselective ligation: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety,... Agent:

20110236931 - Chemical and biochemical adducts as biomarkers for organophosphate exposure: Provided is a method to identify OP-adducted biomarkers of OP exposure as well as compounds containing OPs that can provide OP adducts.... Agent: Human Biomolecular Research Institute

20110236932 - Biopharmaceutical plant in a column: The present invention relates to a series of therapeutic material processing devices stacked into a column, hereby creating a bio material process plant with extremely small foot-print and all the processing devices being of single-use capabilities for lowest possible cost and methods of operating said column.... Agent: Stobbe Tech A/s

20110236933 - Recombinant eukaryotic expression plasmid encoding ppri gene of deinococcus radiodurans r1 and its functions: The present invention concerns a novel recombinant eukaryotic expression plasmid pCMV-HA-pprI encoding the pprI gene isolated from Deinococcus radiodurans R1, the method for preparing pCMV-HA-pprI, and its expression in human 293T cells. The present invention also discloses the optimal method and process of pprI gene transfection by in vivo electroporation,... Agent: Soochow University

20110236934 - Production of globosides oligosaccharieds using metabolically engineered microorganisms: The present invention relates to the large scale in vivo synthesis of globosides oligosaccharides; especially globotriose, globotetraose and globopentaose, which are the carbohydrate portions of globotriosylceramide (Gb3Cer), globotetraosylceramide (Gb4Cer) and globopentaosylceramide (Gb5Cer) respectively. It also relates to high yield production of potential anticancer vaccines of the globo-series glycosphingo lipids, including... Agent: Centre National De La Recherche Scientifique (cnrs

20110236935 - Oxidation process: A method of oxidising a saccharide, by contacting the saccharide with an alcohol dehydrogenase (ADH) enzyme selected from a quinone redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide (NAD+) redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide phosphate (NADP+) redox cofactor-dependent ADH, and any combination thereof is described. An oxidised saccharide obtainable... Agent:

20110236936 - Method for enhancing production polyhydroxyalkanoic acid from microorganism strains: Provided is a method for enhancing the production of polyhydroxyalkanoic acid (PHA) from microorganism strains by disrupting a gene associated with the production of an exobiopolymer (EBP) in the Pseudomonas strain to redirect the carbon flux toward the production of the polyhydroxyalkanoic acid, thereby enhancing the production of the polyhydroxyalkanoic... Agent: Industry-academic Cooperation Foundation Gyeongsang National University

20110236937 - Multi-stage fermenter nutrient feeding: A method for operating a fermenter system. In one instances, the method comprises flowing biomass and liquid in opposite directions through a fermenter train comprising a plurality of fermenters, and introducing a nutrient to any of the plurality of fermenters to optimize the production carboxylate products in the fermenter system.... Agent: The Texas A&m University System

20110236938 - Biofuel production: Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity... Agent: Bio Architecture Lab, Inc.

20110236939 - Biofuel production: Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity... Agent: Bio Architecture Lab, Inc.

20110236940 - Method of preparing piceatannol using bacterial cytochrome p450 and composition therefor: Provided is a method of preparing piceatannol, and more particularly, to a method of preparing piceatannol from resveratrol using bacterial cytochrome P450 BM3 (CYP102A1) or mutants thereof, and a composition and a kit therefor.... Agent: Glo Biotech

20110236941 - Recombinant microorganism and methods of production thereof: A novel genetically modified microorganisms capable of using CO to produce 1-butanol and/or a precursor thereof, novel methyltransferases and nucleic acids encoding same, methods for producing genetically modified microorganisms using said novel methyltransferases, and methods of producing 1-butanol and/or a precursor thereof by microbial fermentation.... Agent: Lanzatech New Zealand Limited

20110236942 - Reduced by-product accumulation for improved production of isobutanol: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and... Agent: Gevo, Inc.

20110236943 - Bioprocessing ligno-cellulose into ethanol with recombinant clostridium: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell... Agent: L'institut National Des Sciences Appliquees (insa)

20110236944 - Method for producing intermediate material intended for ethanol production, and resulting intermediate material: A process for the production of an intermediate product from a lignocellulosic raw material that is intended for the production of ethanol, which process includes pulping the raw material in an extruder at a temperature of between 60° C. and 180° C., in the presence of a quantity of water... Agent: Valagro Carbone Renouvelable Poitou-charentes

20110236945 - Use of recycled cotton for producing ethanol, and production method: Recycled textile cotton is used for producing ethanol by the execution of a process that includes a) a stage of pretreatment of textile cotton, optionally with grinding of textile cotton, pretreatment of textile cotton that may or may not be ground by pulping 5 in an extruder, b) a stage... Agent: Valagro Carbone Renouvelable Poitou-charentes

20110236946 - Concurrent anaerobic digestion and fermentation of lignocellulosic feedstocks: A process for concurrent production of lignins, fuel alcohol, and biogas from lignocellulosic feedstocks. The process comprises: (1) pretreating a lignocellulosic feedstock to produce a solubilised liquid components stream comprising lignins, lignin-derived compounds, and a cellulosic pulp stream, (2) separating the liquid stream from the cellulosic pulp stream, (3) processing... Agent: Lignol Innovations Ltd.

20110236947 - Reducing methane slack when starting and stopping biogas fermenters: A novel method reduces methane slack when operating a biogas fermenter. When starting up a freshly charged fermenter, the methane portion of the produced biogas is initially so low and the portions of carbon dioxide and nitrogen are so high that the biogas cannot be directly used in a combined... Agent: Bekon Energy Technologies Gmbh & Co., Kg

20110236948 - Magnetic patterning method and system: The present invention relates to a method and apparatus for patterning a substrate. The method comprises providing at least one magnetic pattern generator configured and operable to modulate the magnetic field to induce varying magnetic properties to a magnetic field according to a desired pattern; applying the modulated magnetic field... Agent: Yeda Research And Development Company Ltd.

20110236949 - Methods for processing biological tissues: Methods are provided for removing or separating the cellular and/or soluble macromolecular component of a biological tissue from the extracellular matrix component of the biological tissue, comprising embedding the biological tissue in an electrically conductive semi-solid or solid supporting medium and applying an electric field to the tissue-medium complex. Additionally,... Agent: Colorado State University Research Foundation

20110236950 - Grg23 epsp synthases: compositions and methods of use: Compositions and methods for conferring herbicide resistance or tolerance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include polynucleotides encoding herbicide resistance or tolerance polypeptides, vectors comprising those polynucleotides, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs... Agent: Athenix Corp.

20110236951 - Biocomposite materials and methods for making the same: A particle (and a composition that includes a plurality of the particles) that includes at least one polypeptide molecule and at least one polymer covalently bound to the polypeptide molecule so as to form a polymer shell substantially encompassing the polypeptide molecule, wherein the particle does not define a dimension... Agent: Battelle Memorial Institute

20110236952 - Novel substrates of o6-alkylguanine-dna alkyltransferase and mutants thereof: p

20110236953 - Embryonic cerebrospinal fluid (e-csf), proteins from e-csf, and related methods and compositions: We have performed a proteomic analysis of embryonic cerebrospinal fluid (e-CSF) in human and rats. Based on this discovery, the invention features methods and compositions for cell culture including components of e-CSF or fragments thereof. Also provided are methods for extraction of e-CSF.... Agent: Beth Israel Deaconness Medical Center

20110236954 - Cellulase production method based on the regulation of the dissolved oxygen pressure oscillation in the culture medium: The present invention relates to a method of producing cellulolytic and/or hemicellulolytic enzymes by a cellulolytic microorganism in a stirred and aerated bioreactor, comprising a growth stage in the presence of a carbon source and a production stage in the presence of a carbon-containing inductive substrate, wherein the supply of... Agent: Ifp Energies Nouvelles

20110236955 - Arylacylamidase gene and method of using the same: The present invention provides an efficient method of producing an arylacylamidase. In an aspect, the present invention provides (a) a DNA comprising the base sequence shown in the sequence listing under SEQ ID NO:1, or (b) a DNA capable of hybridizing, under stringent conditions, with a DNA comprising the base... Agent: Kaneka Corporation

20110236956 - Multicistronic sirna constructs to inhibit tumors: Multicistronic short interfering RNA constructs targeting in various combinations a human urokinase-type plasminogen activator receptor (uPAR), human urokinase-type plasminogen activator (uPA), human matrix metalloprotease 9 (MMP-9) and cathepsin B (CB) inhibit tumors.... Agent: The Board Of Trustees Of The University Of Illinois

20110236957 - Nanoparticle labeling reagents and methods of use: Compositions and methods for labeling biological targets using a conjugate of a luminescent component and a targeting molecule attached to a nanoparticle core structure are described. The labeling conjugates offer high intensity and low background, and are ideal for histology and pathology.... Agent: The Regents Of The University Of California

20110236958 - Multistory bioreaction system for enhancing photosynthesis: The present invention relates to a multistory system for using waste carbon dioxide and waste heat to facilitate cultivation of photosynthetic organisms. In particular, the present invention relates to a multistory system with the incorporation of upconverting and downconverting luminescent materials and other components suitable for enhancing growth of photosynthetic... Agent:

20110236960 - Apparatus and methods for integrated sample preparation, reaction and detection: Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also... Agent: Genturadx, Inc.

20110236959 - Method of manufacturing planar bio-test strip and product thereof: A planar bio-test strip includes a carrier plate, a conductive circuit formed on the carrier plate by evaporation, a testing electrode terminal and an electrode circuit terminal formed at front and rear ends of the conductive circuit respectively, and an enzyme reacting area coupled to a front end of the... Agent:

20110236961 - Systems and methods for treating landfill gas using landfill leachate: Embodiments of the present invention are directed to systems and methods for treating landfill gas using landfill leachate. In one embodiment of the present invention, a method includes receiving landfill leachate from at least one of a plurality of sources, and pretreating the landfill leachate to adjust at least one... Agent:

20110236962 - Calibratable sensor unit for reaction vessels: The present invention relates to a calibratable sensor unit for a reaction vessel, such as for example a fermenter (48), in particular a disposable fermenter, comprising at least one sensor device (14) to be calibrated and at least one compartment (26, 28, 30) containing a calibrating agent, the at least... Agent: Hamilton Bonaduz Ag

20110236963 - System and method for analyte measurement: A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon... Agent:

20110236964 - Dna sequencing system: An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection... Agent: Life Technologies Corporation

20110236965 - Panelized drum system: A rotating drum that is made from a plurality of panels that are connected to form sub-cylinders that, in turn, are connected to form a drum cylinder. Drum heads are connected at both ends of the drum cylinders. The drum may be rotated using rotational means. In one preferred embodiment... Agent:

20110236967 - Promiscuous her-2/neu cd4 t cell epitopes: The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such a epitope and a... Agent: Dendreon Corporation

20110236966 - Single lentiviral vector system for induced pluripotent (ips) stem cells derivation: The present invention is based on the discovery that a single lentiviral vector expressing multiple individual transcription factor proteins from a single multi-cistronic mRNA can reprogram a fibroblast cell to a stem cell-like cell. These reprogrammed induced pluripotent stem (iPS) cells are pluripotent. Additions of the Cre-LoxP sequences into the... Agent: Boston Medical Center Corporation

20110236968 - Humanized antibodies against monocyte chemotactic proteins: The invention provides humanized antibodies that bind to a plurality of β-chemokines, particularly monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. The invention also provides therapeutic reagents and methods of treating disorders associated with detrimental MCP activity.... Agent: Biogen Idec Ma Inc.

20110236969 - Methods of generating variant proteins with increased host string content and compositions thereof: The present invention relates to novel methods for generating variant proteins with increased host string content, and proteins that are engineered using these methods.... Agent: Xencor, Inc.

20110236970 - Chamber of a bioreactor platform: Disclosed herein is mesoscale bioreactor platform comprising an upwards open chamber for a biological cell, which chamber via a first port is in communication with a first channel for conducting an influent stream of a liquid into the chamber and via a second port is in communication with a second... Agent: Smart Biosystems Aps

20110236971 - Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions: Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions are disclosed... Agent:

20110236972 - Nucleic acid compounds for inhibiting birc5 gene expression and uses thereof: The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing BIRC5 gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand... Agent: Marina Biotech, Inc.

20110236973 - Centrosome proteins and uses thereof: The invention includes nucleic acids and polypeptides that play important roles in centrosomes and cellular functions involving centrosomes. In addition, the invention encompasses antibodies, ribozymes, antisense nucleic acids, RNAis, and siRNAs that can be used to modulate the function of the nucleic acids and polypeptides of the invention. Such modulation... Agent: University Of Massachusetts, A Massachusetts Corporation

20110236974 - Compositions and methods for making and using laminin nanofibers: The present invention provides methodologies and parameters for fabrication of the hybrid biomaterial by blending pure laminin or complex extracts of tissues containing laminin with biopolymers such as polycaprolactone (PCL), polylactic/polyglycolic acid copolymer (PLGA) or Polydioxanone (PDO) in fluoroalcohols (HFP, TFA), fabrication of substrates and scaffolds and devices from the... Agent: University Of Virginia Patent Foundation

20110236975 - Growth factor which acts through erb b-4 rtk: The present invention provides for isolated polypeptides capable of binding ErbB-4.... Agent: Yeda Research And Development Co. Ltd.

20110236976 - Vector comprising multiple homologous nucleotide sequences: The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide sequences with different bases that do not alter the encoded amino acid sequence. The invention allows for the reduction of intramolecular recombination between homologous... Agent:

20110236977 - Dental stem cell differentiation: Provided is a method of preparing an embryonic stem cell-like cell, a method of preparing an insulin-secreting cell or pancreatic beta-like cell, a method of preparing a chondrocyte-like cell, a method of preparing a myocyte-like cell, and a method of preparing a hair follicle-like cell. A composition comprising a dental... Agent: The Trustees Of Columbia University In The City Of New York

20110236978 - Reprogramming cells toward a pluripotent state: The present invention relates to a process for preparing reprogrammed cells, in particular for preparing pluripotent and multipotent stem cells and to the pluripotent and multipotent stem cells prepared by said processes.... Agent: Fraunhofer-gesellschaft Zur Forderung Der Angewandten Forschung E. V.

20110236979 - Apparatus for generating electrical pulses and methods of using same: A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in... Agent: Eastern Virginia Medical School

  
09/22/2011 > 103 patent applications in 59 patent subcategories. class, title,number

20110229870 - Disintegration of cellular components in body fluids: The present invention refers to a method of processing a biological fluid which comprises cellular components by a freezing/thawing treatment. The method is particularly useful for preparing biological samples for analyte detection.... Agent: Sebo Gmbh

20110229871 - Nucleoside-containing compositions and methods for treating red blood cells: Blood storage and/or rejuvenating compositions that include D-ribose and a nucleoside other than inosine (e.g., guanosine) are disclosed herein. Such compositions can be useful in methods for treating (e.g., storing and/or rejuvenating) red blood cells.... Agent:

20110229873 - Fermentation process using specific oxygen uptake rates as a process control: Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using... Agent:

20110229872 - Microfabricated cell sorter: The invention provides a microfabricated device for sorting cells based on a desired characteristic, for example, reporter-labeled cells can be sorted by the presence or level of reporter on the cells. The device includes a chip having a substrate into which is microfabricated at least one analysis unit. Each analysis... Agent: California Institute Of Technology

20110229876 - Biomarkers for the detection of head and neck tumors: A method of detecting the presence of specific human papilloma virus and host cell biomarkers associated with head and neck tumors in biological samples, like saliva, blood or biopsy tissue, obtained from a subject.... Agent: Loma Linda University

20110229874 - Compositions and methods useful for hcv infection: The present invention provides compositions comprising cells that can effectively produce HCV after HCV infection, compositions for culturing the cells, methods for making the composition and methods for infecting the cells in the composition with HCV. The present invention also provides methods for assaying HCV production and methods for evaluating... Agent: Vertex Pharmaceuticals Incorporated

20110229875 - Method of measuring human cyp3a inducibility: e

20110229882 - Diagnosing and monitoring response to treatment of solid organ tissue disease: Techniques for diagnosing and monitoring response to treatment of a solid organ tissue disease in a patient are provided. For example, a technique for diagnosing a solid organ tissue disease in a patient includes obtaining at least one of one or more blood-derived nucleated acellular components and one or more... Agent:

20110229881 - Dna-containing ink composition: An ink, which contains DNA and is hardly decomposed by an external stimulus such as ultraviolet light, heat, an acid or an alkali, is provided. A method of easily analyzing a DNA in an ink composition is also provided. An ink composition containing a DNA and having a water-tolerance at... Agent: Educational Corporation Kansai Bunri Sougougakuen

20110229877 - Enzyme-pore constructs: The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. The constructs can be used to generate transmembrane protein pores having a nucleic acid... Agent: Oxford Nanopore Technologies Limited

20110229880 - Gene silencing: The invention provides a mirtron or a gene capable of expressing a mirtron for use in modifying the expression of a target gene in a mammalian cell to prevent or treat a disease, the sequence of the mirtron comprising: (i) a 5′ splice site; (ii) a 3′ splice site; (iii)... Agent: Isis Innovation Limited

20110229878 - Human consensus sodium-iodide symporter repressor (nis-repressor) binding site: The present disclosure relates to a Sodium-Iodide Symporter-repressor (NIS-repressor) binding site (NRBS) consensus sequence consisting of a DNA molecule having the sequence: 5′-T/C(G/A)GCCT(T/C)A(G/A)TTTCCCCA(T/C)CTGT-3.′ The disclosure further relates to methods of screening compounds and other molecules that bind to or inhibits the NIS-repressor or inhibits or interferes with the binding of... Agent:

20110229879 - Methods and compositions for nuclear staining: The present invention relates to compositions, methods, and kits suitable for detecting nucleic acids in a biological sample. The nuclear staining composition of the present invention contains a pH buffering reagent, a solubilizing reagent, a basic dye, and an aqueous medium. The composition can be used alone to detect nucleic... Agent: University Of Rochester

20110229883 - Biochemical markers for disease states and genes for identification of biochemical defects: The present invention relates to a system utilizing biochemical markers and genetic markers to diagnose, predict, and/or monitor intervention of a number of diseases and conditions that have unresolved oxidative stress as an important component. The present invention relates generally to markers and assays for diagnosing, predicting, and monitoring disease,... Agent:

20110229888 - Compositions and methods for the detection of genomic features: The invention provides compositions and methods for the detection of gene copy number and/or chromosome copy number in a multiplexed reaction. The assays and kits described herein are applicable for the identification, diagnosing, and monitoring of disorders including, but not limited to cancer, developmental and degenerative disease, neurological disorders, and... Agent:

20110229887 - Detection of nucleic acid amplification products in the presence of an internal control sequence on an immunochromatographic strip: Compositions and methods useful in nucleic acid assays are provided. The invention permits detection of test and control nucleic acids. Test nucleic acids can be immobilized at multiple locations, such that amplification of either a test nucleic acid or a control nucleic acid provides a captured nucleic acid in a... Agent: Biohelix Corporation

20110229889 - Dopaminergic neuron proliferative progenitor cell marker msx1/2: The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can... Agent: Eisai R&d Management Co., Ltd.

20110229890 - Egfr mutations: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated... Agent:

20110229892 - Method for predicting a patient's responsiveness to anti-folate therapy: A method of predicting responsiveness of a subject to a folylpolyglutamate synthetase (FPGS) dependent anti-folate is provided. The method comprises analyzing for a presence or absence of a splice variant of FPGS or a polypeptide encoded thereby, in a sample of the subject, wherein the presence of the splice variant... Agent:

20110229884 - Method of genome-wide nucleic acid fingerprinting of functional regions: A method of specifically amplifying desired regions of nucleic acid from a sample is provided. The method uses a plurality of first and second PCR primers, each having a region of fixed nucleotide sequence identical or complementary to a consensus sequence of interest and a region of randomized nucleotide sequence... Agent:

20110229893 - Method of measuring cytokeratin 19 mrna: Disclosed is a method of amplifying and detecting cytokeratin 19 mRNA in RNA amplification process, comprising: a step for forming a double-stranded DNA containing a promoter sequence with a reverse transcriptase by use of a combination of oligonucleotides consisting of a first primer having a sequence homologous to a portion... Agent: Tosoh Corporation

20110229885 - Methods and compositions for determining predisposition to inflammation-mediated cardiovascular disease: The present invention provides methods and compositions for detecting a predisposition to an inflammation-mediated cardiovascular disease in a human subject by detecting a level of leukotriene C4 synthase (LTC4S) gene product in a sample from a human subject indicative of a predisposition to an inflammation-mediated cardiovascular disease or detecting the... Agent:

20110229894 - Methods for detecting an increased susceptibility to cancer: The invention relates to methods for detecting an altered susceptibility to breast and ovarian cancer in a subject carrying a BRCA mutation, comprising determining the nucleic acid sequence of a polymorphism of a microRNA-related gene.... Agent: Tel Hashomer Medical Infrastructure And Services L Td.

20110229886 - Methods for detecting aneuploidy using microparticle multiplex detection: The present invention provides a method for the detection and sorting of microparticles in a mixture of microparticles. The method of the present invention allows for the detection and sorting of many distinct microparticle classes. Detection and sorting is on the basis of microparticle size, the fluorescence spectrum of any... Agent:

20110229891 - Syngap1 dysfunctions and uses thereof in diagnostic and therapeutic applications for mental retardation: The invention identifies Syngap1 dysfunctions as causative of mental retardation. Described are methods of detecting mental retardation and methods of detecting non-syndromic mental retardation (NSMR) in a human subject. Particular methods comprise sequencing a human subject's genomic DNA for comparison with a control sequence from an unaffected individual. Also described... Agent: Centre Hospitalier De L'universite De Montreal

20110229899 - Detection of mutations in a gene encoding ikb kinase-complex-associated protein to diagnose familial dysautonomia: A method for detecting the presence in a subject of a polymorphism linked to a gene associated with familial dysautonomia, said method comprising detecting a disruptive mutation in a gene of said subject encoding the IκB kinase-complex-associated protein, and, preferably, detecting a T→C change in position 6 of the donor... Agent:

20110229903 - Determination of immunoglobulin encoding nucleic acid: It is reported herein a method for the determination of the amount of immunoglobulin-encoding mRNA comprising: a) providing a sample, b) performing a polymerase chain reaction for amplifying the light chain with the primers of SEQ ID NO: and 24 and the probe of SEQ ID NO: 33, and/or c)... Agent:

20110229898 - Dna analyzer: Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second... Agent: Lockheed Martin Corporation

20110229896 - Dna diagnostic screening for turner syndrome and sex chromosome disorders: The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of Turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the X and Y chromosomes.... Agent: Yale University

20110229900 - Method for detecting microorganisms of kingella genus: The invention relates to a method for detecting Kingella microorganisms through PCR of a chaperonin gene.... Agent: Universite Paris Diderot-paris 7

20110229902 - Method for determining the resistance status of fungi and yeasts, in particular of aspergillus fumigatus: The invention relates to a method for determining the resistance status of fungi and yeasts in a body sample of a patient suspected of having an invasive infection, comprising the steps of isolating DNA from a body sample of the patient, identifying mutations in a gene of the fungus or... Agent: Stichting Ter Bevordering Van De Farmacodynamiek

20110229895 - Method for diagnosing polycystic kidney disease: The present invention relates to the diagnosis of renal disorders, in particular of polycystic kidney disease (PKD). The invention provides methods for diagnosing or monitoring the progression of PKD and test kits useful in those methods.... Agent:

20110229901 - Methods for identifying the habitats of insects: e

20110229897 - Optical approach for microfluidic dna electrophoresis detection: Aspects of the disclosure provides a DNA analyzer to facilitate an integrated single-chip DNA analysis. The DNA analyzer includes an interface for coupling a microfluidic chip to the DNA analyzer. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second... Agent: Lockheed Martin Corporation

20110229904 - Recombinant construct for detection of halogenated aromatic hydrocarbons: The present invention describes a recombinant construct for detection of halogenated aromatic hydrocarbon compounds. A method for detecting halogenated aromatic hydrocarbon compounds using the recombinant construct is also described.... Agent: National Health Research Institutes

20110229905 - Compositions and methods for diagnosing and treating cancer and neurodegenerative diseases rlated to beclin-1: The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a... Agent: Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science

20110229906 - Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of hiv/aids: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring... Agent:

20110229908 - Methods and products for measuring free immunoglobulin light chain molecules: The present invention provides improved methods for measuring the ratio of free K immunoglobulin light chain molecules to free λ immunoglobulin light chain molecules in a test sample, using a monoclonal antibody that specifically binds to free K and a monoclonal antibody that specifically binds to free λ. The application... Agent:

20110229909 - Rho1-gamma amino butyric acid c receptor-specific antibodies: This invention provides antibodies immunologically specific for ρ1-GABAC receptor protein. The invention also provides methods of making and methods of using said antibodies and kits containing the antibodies.... Agent: The Board Of Trustees Of The University Of Illinois

20110229907 - Use of cardiac hormones to assess risk of cardiovascular complication from volume overload: The disclosure relates to the use of cardiac hormones, particularly natriuretic peptides, for assessment of risk of suffering from a cardiovascular complication, particularly heart disease or acute coronary syndrome, as a consequence of intravasal volume overload. In particular, the disclosure relates to a method for diagnosing the risk of a... Agent:

20110229910 - Fluorescent substrates for neurotransmitter transporters: The invention is based on the finding that IDT307 and analogs thereof are fluorescent substrates transported by several neurotransmitter transporters. Provided are methods for the analysis of neurotransmitter transport and binding using IDT307 and its analogs. The invention also provides rapid methods for screening for modulators of neurotransmitter transport.... Agent:

20110229913 - Method for amplification of signal in immunochromatographic assay and immunochromatographic kit using the method: The present invention relates to a method for amplifying a signal in an immunochro-matographic assay for high-sensitivity detection of an analyte and an immunochromatographic kit using the method, which amplifies a signal by controlling a flow rate by discrimination between the size of a first indicator and the size of... Agent: Infopia Co., Ltd.

20110229911 - Azurophilic granule proteases as markers in cardiological diseases: The present invention is concerned with an assay for detecting and/or determining the level of a protease from azurophilic granules of polymorphonuclear neutrophils or a complex thereof with an endogenous inhibitor for risk stratification and/or prognosis and/or therapy control and/or monitoring of a patient having a cardiological disease or condition.... Agent: B.r.a.h.m.s. Gmbh

20110229912 - Anti-preproprotein and anti-preprotein antibodies as immunohistochemical markers: It is disclosed herein that antibodies specific for preproproteins or preproteins, which are synthesized by certain types of cells or tissues, can be used in immunohistochemistry assays to discriminate between the intracellular component of the protein (including the preproprotein, preprotein and/or proprotein forms of the protein) from the secreted component... Agent:

20110229915 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Epidermal growth... Agent: Astute Medical, Inc.

20110229914 - Use of antibody secreting cell elispot to assess antibody responses following antigen exposure: Disclosed are methods and kits for early detection of antigen exposure through the presence or absence of antigen-specific antibodies.... Agent:

20110229916 - Nanofibers with high enzyme loading for highly sensitive biosensors: The invention provides high enzyme loading nanofibers and processes utilized in their fabrication, the nanofibers suitable for use as a new class of highly sensitive and stable biosensors capable of monitoring glucose at low levels. The biosensors, comprising nanofiber enzyme materials fabricated from organic solvent-based polymer-enzyme systems, can be used... Agent: The University Of Akron

20110229917 - Multiplex liquid tissue™ method for increased proteomic coverage from histopathologically processed biological samples, tissues and cells: The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set... Agent:

20110229918 - Method of quantifying transient interactions between proteins: The invention relates to a precursor for producing sintered metallic components, a method for producing the precursor and the production of the components. The object of the invention is to disclose possibilities of being able to produce sintered metallic components, which render possible an increased physical density and a reduced... Agent: Covalys Biosciences Ag

20110229919 - Combination of spla2 activity and oxpl/apob cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event.: combining the measurements, the combined value of sPLA2 activity and OxPL/apoB being indicative of having or a risk of having or developing a cardiovascular disease and/or cardiovascular event.... Agent: Universite Paris Diderot-paris 7

20110229920 - Screening methods for identifying specific staphylococcus aureus inhibitors: Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises inhibiting ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method... Agent: Trana Discovery, Inc.

20110229921 - Methods of assaying urinary neutrophil gelatinase-associated lipocalin (ungal) in the prognosis of cadaveric kidney transplant function in a patient, including a patient diagnosed with delayed graft function (dgf), a method of assaying ungal in the assess: A method of prognosticating cadaveric kidney transplant function in a patient; a method of prognosticating cadaveric kidney transplant function in a patient diagnosed with DGF; a method of assessing risk of DGF in a patient, who has been diagnosed with EGF; and a kit comprising at least one component for... Agent: Abbott Laboratories

20110229922 - Screening assays for the identification of bace2 inhibitors: The present invention relates to screening assays for the identification of BACE2 inhibitors.... Agent:

20110229923 - Crystal of a cytochrome-ligand complex and methods of use: The teachings relates to the three-dimensional structure of a crystal of a cytochrome protein complexed with a ligand. The three-dimensional structure of four cytochrome P450 2A6-ligand complexes are disclosed. Cytochrome P450 2A6-ligand crystal structures, wherein the ligand is an inhibitor molecule, are useful for providing structural information that may be... Agent: The Scripps Research Institute

20110229925 - Assays for performance of organisms in phenotrons: A phenotron assay can be used for determining an adverse effect on health by: identifying an exposure condition to be studied for an adverse effect on the health of an organism; providing a phenotron having one or more sensors each configured to sense a signal; introducing one or more test... Agent:

20110229928 - Device and method for microwave assisted cryo-sample processing: Embodiments are provided that provide for devices and methods for microwave-assisted cryo-sample processing. In some embodiments, a system for microwave-assisted cryo-sample processing of a sample includes a chamber adapted to receive microwave radiation and a device disposed in the chamber that is configured to maintain a sample under cryo conditions... Agent:

20110229924 - Fluorescent ion indicators and their applications: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations.... Agent:

20110229927 - Sample port of a cell culture system: Disclosed herein is a cell culturing system comprising a culturing chamber for culturing a biological cell in a growth medium and a sensor for measuring a signal in the spent growth medium, wherein the culturing chamber is provided in a mesoscale bioreactor platform with an inlet opening for an influent... Agent: Smart Biosystems Aps

20110229926 - Storing method of measuring apparatus of airborne floating bacteria: [Solving Means] In a storing method of a measuring apparatus of airborne floating bacteria for capturing airborne floating bacteria on a gel of a capturing carrier, forming into a sol in the measuring apparatus, and measuring the light emission of the ATP, the aseptic water existing in the piping system... Agent: Hitachi Plant Technologies, Ltd.

20110229929 - Arsenical fluorescent agents and assays: The invention provides methods and compositions for labeling dithiol-containing analytes.... Agent:

20110229930 - Microorganism comprising particles and uses of same: A particle is disclosed. The particle comprising: (i) at least one inner core which comprises a solid matrix of nutrients for microorganism growth; (ii) an inner membrane being fabricated from a water-soluble polymer, the inner membrane surrounding the inner core and a population of dried microorganisms; and (iii) an outer... Agent:

20110229931 - Engineering intracellular sialylation pathways: Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the... Agent:

20110229932 - Artificial chromosome vector: According to the present invention there is provided a method of producing a protein in a eukaryotic cell line, comprising the steps of a) providing a backbone of an artificial chromosome, b) recombining the nucleic acid encoding said protein into said backbone to generate an expression vector, c) introducing said... Agent:

20110229933 - High titer antibody production: The present invention provides, in part, methods for recombinantly expressing proteins at a high level along with cell culture media for doing the same.... Agent: Sachering Corporaton

20110229935 - Process for the production of the actinobacillus pleuropneumoniae toxin apxi employing a culture medium comprising calcium-borogluconate complex: The present invention pertains to a method to produce RTX-toxin Apxl by culturing Actinobacillus pleuropneumonica bacteria in a liquid culturing medium that supports growth of the bacteria, to which medium a calcium salt is added to form calcium ions in the medium, wherein the culturing medium contains borogluconate to form... Agent:

20110229934 - Process for the production of the actinobacillus pleuropneumoniae toxins apxi or apciii in a liquid culture medium under supply of air enriched in carbon dioxide: The current invention pertains to a method to produce RTX-toxins ApxI or ApxIII by culturing Actinobacillus pleuropneumoniae bacteria in a liquid culturing medium that supports growth of the bacteria, characterised in that air is passed through the medium, wherein the air has a carbon dioxide content above normal atmospheric level... Agent:

20110229936 - Polypeptides having beta-glucosidase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes, Inc.

20110229937 - Corynebacterium glutamicum genes encoding regulatory proteins involved in the production of methionine: Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells... Agent: Evonik Degussa Gmbh

20110229938 - Method for amplifying locus in bacterial cell: Certain aspects of this disclosure relate to a method of amplifying a genomic locus. In certain embodiments, the method may comprise: a) contacting a population of bacterial host cells with an inhibitor of an essential enzyme, where the bacterial host cells comprise a genomic locus of the structure: A1-P-M-A2, where... Agent:

20110229939 - Method for amplifying double stranded target sequence in double stranded dna: The present invention relates to a nested PCR with high specificity. The present invention provides a method for amplifying a target sequence (1), and the method demonstrates high efficiency of amplification of the single stranded target sequence and a significant effect on inhibiting nonspecific amplifications. In one embodiment, at the... Agent: Panasonic Corporation

20110229940 - Method for producing l-amino acid: The present invention relates to a method for producing an L-amino acid by reacting an enantiomeric mixture of an N-succinyl amino acid with L-succinylase in the presence of N-acylamino acid racemase to specifically hydrolyze the L-form. In particular, the present invention relates to a method for producing an L-amino acid... Agent: Kaneka Corporation

20110229941 - Novel gene cluster: Novel isolated DNA sequences which comprise all or part of a gene cluster encoding sanglifehrin synthase, processing and regulatory genes involved in the biosynthesis of a mixed non-ribosomal peptide/polyketide compound, or mutants having altered biosynthetic capability, polypeptides or mutants thereof encoded by DNA or the mutants, vectors containing the DNA... Agent:

20110229943 - Methods for converting glucose to ascorbic acid: Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described.... Agent: Danisco US Inc.

20110229942 - Microbial conversion of oils and fatty acids to high-value chemicals: Microorganisms for the production of high-value chemicals from free fatty acids are provided. The microorganisms comprise genetic mutations that alter fatty acid metabolism. The genetic mutations include a mutation or deletion of a fadR gene in which the FadR enzyme activity is partially or substantially eliminated and a mutation in... Agent: Glycos Biotechnologies, Incorporated

20110229944 - Fad4, fad5, fad5-2, and fad6, novel fatty acid desaturase family members and uses thereof: The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g.,... Agent: Bioriginal Food & Science Corp.

20110229945 - Dicarboxylic acid production by fermentation at low ph: The present invention relates to a process for the production of a dicarboxylic acid. The process comprises fermenting a yeast in the presence of a carbohydrate-containing substrate and low amounts of oxygen at a pH value at which at least 50% of the dicarboxylic acid is in the acid form.... Agent:

20110229946 - Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of... Agent: Genomatica, Inc.

20110229949 - Genetically modified yeast strain: A polyploid transformed yeast cell comprising a deleted or disrupted GDH1 gene encoding an NADPH-dependent glutamate dehydrogenase. The polyploid yeast cell shows increased production of ethanol and reduced production of glycerol when compared with a control polyploid yeast cell.... Agent: Greenfield Ethanol Inc.

20110229950 - Method for ethanol production and extraction: A method includes operating an apparatus having a mash circulating and recirculating system with pump and fermentation tank, an atmosphere circulating and recirculating system with blower for recirculating atmosphere between the tank and an ethanol-removal station, and an integrated refrigerating heat-transfer system with first coils remote from the tank for... Agent:

20110229948 - Method for producing ethanol from a sustainable renewable biomass feedstock: Disclosed is a method of producing ethanol from a sustainable renewable biomass feedstock. The ethanol is produced in a processing plant contiguous to the acreage providing the biomass. The process is a closed loop operation having a dedicated crop grown year round producing multiple crops per acre. The biomass feedstock... Agent:

20110229947 - Novel ethanologenic clostridium species, clostridium coskatii: A novel clostridia bacterial species (Clostridium coskatii ATCC No. PTA-10522, “PS02”) is provided. Under anaerobic conditions C. coskatii can convert CO and/or H2 and/or CO2 to ethanol or acetate. Thus, this novel bacterium is capable of transforming waste gases (e.g. syngas and refinery wastes) into useful products.... Agent: Coskata, Inc.

20110229951 - Bacteria-based gas generator: Disclosed is an apparatus having: a pressure chamber and a gas-producing microorganism within the chamber. The pressure chamber is capable of maintaining a gas pressure of at least 0.5 psi above atmospheric pressure.... Agent: The Government Of The United States Of America, As Represented By The Secretary Of The Navy

20110229952 - Method and apparatus for avalanche-mediated transfer of agents into cells: The present invention provides a method and apparatus for transferring an agent into a cell. The method includes the steps of providing an agent outside of a cell and generating a vapor bubble and a plasma discharge between an avalanche electrode and a conductive fluid surrounding the cell. The vapor... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20110229953 - Method for producing different populations of molecules or fine particles with arbitrary distribution forms and distribution densities simultaneously and in quantity, and masking member therefor: A method to form populations of fine particles or molecules on a substrate by specifying the distribution form and distribution surface density, wherein a masking member provided with parallel through-holes and having a tilted wall structure to achieve the target distribution form and distribution density is prepared; a solution or... Agent: Japan Science And Technology Agency

20110229954 - Nuclease reduction: A method for reducing nuclease activity in a subtilisin solution obtained from a fermentation broth comprising a) adjusting the pH of the subtilisin solution to a pH in the range of from pH 8.5 to pH 10.5; b) adding a polyol; c) adjusting the temperature of the subtilisin solution to... Agent: Novozymesa/s

20110229955 - Luciferases and methods for making and using the same: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides... Agent: The Regents Of The University Of California

20110229956 - Novel variant hyprocrea jecorina cbh1 cellulases: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.... Agent: Genencor International, Inc.

20110229957 - Polymer-mediated electromagnetic field-based particle concentrator: There remains an unmet need for methods to efficiently concentrate and isolate small particles, such as nano-sized and micron-sized particles. The methods herein provide means to fulfill this need through the combination of two independent particle-concentrating mechanisms, yielding unprecedented control, confinement, and concentration enhancement ability. The method is carried out... Agent: Lehigh University

20110229958 - Host cells for production of isoprenoid compounds: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the... Agent:

20110229959 - Engineered microorganisms with enhanced fermentation activity: Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms.... Agent: Verdezyne, Inc.

20110229961 - Active microfluidic system for in vitro culture: Described herein are systems and methods for microfluidic cell support, including a microfluidic cell support system and methods for its use. The microfluidic cell support system can include a base assembly, a manifold assembly, and a microfluidic celltray including a microcirculatory path in fluid communication with the manifold assembly. The... Agent: Nanopoint, Inc.

20110229960 - Tape magazine for a hand-held device: The present invention concerns a tape magazine especially for a hand-held device for analysing a body fluid with a test tape that can be unwound from a storage unit and wound onto a waste unit where the waste unit can be driven in order to wind forward the test tape.... Agent:

20110229963 - Stirrer for a bioreactor: A stirrer for a bioreactor has first and second opposed mountings fastened to the inner surfaces of opposite walls of the bioreactor and disposed along a common rotational axis. A first arm has an end connected to the first mounting for rotation about the rotational axis and for pivoting about... Agent: Sartorius Stedim Biotech Gmbh

20110229962 - Temperature-responsive cell culture substrate and method for producing the same: A substrate having a pattern of two or more materials exhibiting different grafting efficiencies for a temperature-responsive polymer that varies its interaction with water in a temperature range of 0 to 80° C. by electron beam irradiation under the same conditions is grafted with the temperature-responsive polymer by simultaneously irradiating... Agent:

20110229964 - Fusion protein delivery system and uses thereof: The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present... Agent: The Uab Research Foundation

20110229965 - Methods of preparing mesenchymal stem cells, compositions and kit thereof: The present invention discloses a method of isolation, pooling and further culturing of Mesenchymal Stem cells (MSC) for clinical application. Present invention also discloses the method of establishing Master Cell bank, followed by Working Cell Bank from which the final therapeutic composition referred to as Investigational Product/Investigational Medicinal Product comprising... Agent:

20110229966 - Nanoparticle-based gene delivery systems: The present invention provides a gene delivery system containing nanoparticles. In more detail, the present invention provides a gene delivery system containing (a) a nanomaterial; (b) an oligonucleotide as an universal binding partner covalently linked to the surface of the nanomaterial; and (c) a cargo comprising (i) a complementary oligonucleotide... Agent: Chung-ang University Industry-academy Cooperation Foundation

20110229967 - Method of culturing conifer somatic embryos using s(+)-abscisic acid: A method for promoting maturation and development of vigorous conifer (gymnosperm) somatic embryos comprising the use of S(+)-ABA as the substantive form of ABA.... Agent: Cellfor Inc.

20110229968 - Ethanol resistance saccharomyces cerevisiae gp-01 by protoplast fusion, method for manufacturing thereof, method for manufacturing yeast containing high content of bio organic germanium by using saccharomyces cerevisiae gp-01 and high water soluble sodium: A biologically pure culture of Saccharomyces cervisiae GP-01, and a method for producing Saccharomyces Cervisiae GP-01 which is ethanol-resistant and obtained by protoplast fusing Saccharomyces Cerevisiae (KCTC 7904) and Candida Ethanolica (KCTC 7181). Further, the present invention provides yeast containing the high content of organic bio-germanium (the yeast Ge-32K) and... Agent: Geranti Pharm Ltd

20110229969 - Cell line for propagation of highly attenuated alphaviruses: The present invention provides an avian cell that is derived from an avian host cell and stably carries at least one DNA sequence in the cell nucleus encoding an alphavirus polypeptide, a method for preparing such an avian cell, and its use in preparing an alphavirus replican particle.... Agent:

20110229970 - Dual-chamber perfusion bioreactor for orthopedic tissue interfaces and methods of use: The subject invention concerns a perfusion bioreactor device and methods of using the same. A bioreactor device of the invention can be used to grow cells and tissue in a controlled in vitro environment. A perfusion bioreactor device of the invention can have multiple perfusion chambers that can be controlled... Agent: Florida State University Research Foundation

20110229971 - Recombinant virus production using mammalian cells in suspension: The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy.... Agent: Applied Genetic Technologies Corporation

20110229972 - Compositions and methods for material transfer into cells: Methods for material transfer into a cell are provided according to the present invention which include electroporation of the cell in the presence of the material, such as nucleic acids, and 2,3-butanedione monoxime; and lipofection with a complex of a lipid-based carrier, such as liposomes, and the material, in the... Agent: The Penn State Research Foundation

  
09/15/2011 > 93 patent applications in 54 patent subcategories. class, title,number

20110223579 - Composition for preserving platelets and method of using the same: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally,... Agent: Biovec Transfusion, LLC

20110223582 - Cell culture device and method of culturing cells: The present invention relates to a cell culture device (1) comprising a disposable culture vessel comprising at least one external wall made of a material having a Young modulus E of less than 50 GPa, in which there is situated at least one cell culture zone and at least one... Agent:

20110223583 - Devices and methods for providing concentrated biomolecule condensates to biosensing devices: Condensing devices and methods for providing a concentrated biomolecule condensate to one or more biosensing devices are provided. The concentrated biomolecule condensate is obtained from a fluid sample which potentially contains traces of one or more target biomolecules. The fluid sample is first separated into a filtered liquid and a... Agent: Early Warning Inc.

20110223581 - Electronically controlled diaphragm pump: An electronically controlled diaphragm pump system is provided. The pump systems comprises a pump housing with a drive gas chamber and a fluid chamber separated by a diaphragm. The drive gas chamber is connected to one or more gas ports for injecting and/or sucking a gas into and out of... Agent: Stobbe Tech A/s

20110223580 - Sample analyzer and sample transporting method: The present invention is a sample analyzer including: a first and a second measurement unit configured to measure a sample accommodated in a sample container; a rack transport unit configured to transport each of a plurality of sample containers held in a sample rack to either the first or the... Agent:

20110223585 - Assay for localized detection of analytes: The present invention relates to a method for detecting an analyte in a sample, said method comprising: (a) contacting said sample with at least one set of at least first and second proximity probes, wherein said probes each comprise an analyte-binding moiety and can simultaneously bind to the analyte, and... Agent: Olink Ab

20110223584 - Oligonucleotides for detecting human papilloma virus in a test sample: Oligonucleotides targeted to HPV Type 16 and/or Type 18 nucleic acid sequences which are particularly useful to aid in detecting HPV type 16 and or 18 are described. The oligonucleotides can aid in detecting HPV Type 16 and/or Type 18 in different ways such as by acting as hybridization assay... Agent: Gen-probe Incorporated

20110223591 - Methods and device to constrain multicellular arrangements in stable, stationary and reproducible spatial configuration: The present invention relates to methods and devices to obtain multicellular arrangements in stable, stationary and reproducible spatial configuration, and optionally with controlled internal cell organization, methods for preparing such devices, methods for studying the cells shapes, the cells architectures, the cells mechanical equilibrium, the cell-cell interaction, the cell movement... Agent: Commissariat A L'energie Atomique Et Aux Energies Alternatives

20110223586 - Optical particle characterization system: A particle characterization system including a flow source to produce a stream of particles; a source of light or other energy directed at the stream of particles to cause fluorescence or scattered light to be emitted from the particles; a detector of the fluorescent or scattered light including three or... Agent:

20110223587 - Optical particle characterization system: A particle characterization system including a flow source to produce a stream of particles; a source of light or other energy directed at the stream of particles to cause fluorescence or scattered light to be emitted from the particles; a detector of the fluorescent or scattered light including a plurality... Agent:

20110223590 - Single-molecule detection system and methods: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.... Agent: Industrial Technology Research Institute

20110223589 - Solid phase nucleic acid extraction from leukoreduced blood: Products for and a method of capturing and storing nucleic acid from leukoreduced patient blood, where the products capture sufficient quantities for use in PCR and analysis of nucleic acid, are described. The products are made by heating a mixture of magnetic beads, silica particles, alkyl silicate (e.g., Silbond 4,... Agent: Biosample LLC

20110223588 - Solid phase nucleic acid extraction from small sample volumes, and release of controlled quantities: Products for and a method of capturing and storing nucleic acid from patient blood, plants or other samples (e.g., purified DNA or RNA), for use in analysis of nucleic acid are described. The products are made by heating a mixture of magnetic beads, silica particles, alkyl silicate (e.g., Silbond 4,... Agent: Biosample LLC

20110223603 - Diagnosing and monitoring response to treatment of non-incontinent urological and related diseases: Techniques for diagnosing and monitoring response to treatment of non-incontinent urological disorders (NIUD) in a patient are provided. For example, a technique for diagnosing NIUD in a patient includes obtaining peripheral blood-derived nucleic acid containing nucleated acellular components such as serum and/or plasma and/or nucleated cellular components from the patient... Agent:

20110223601 - Method for pairwise sequencing of target polynucleotides: The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of... Agent: Illumina Cambridge Limited

20110223600 - Method for predicting athletic performance potential: A method and assay for predicting athletic performance potential of a subject, such as a thoroughbred race horse, comprising the steps of assaying a biological sample from a subject for the presence of a single nucleotide polymorphism in one or more genes associated with athletic performance. The athletic performance genes... Agent:

20110223598 - Method for real-time detection of salmonella in food using a cleavable chimeric probe: A method is described for the real-time detection of Salmonella species in foods and on surfaces. Salmonella are enriched in media to increase their cell density prior to analysis. DNA is recovered by lysis in the presence of azide, proteinase K, and detergent. Real-time detection of Salmonella species is performed... Agent: Samsung Techwin Co., Ltd.

20110223597 - Methods relating to olanzapine pharmacogenetics: There is significant variability in subject clearance, half-life and side-effects from treatment with olanzapine (OLZ) in subjects. Methods for aiding in determining therapeutic efficacy of olanzapine in a subject are provided according to embodiments of the present invention which include identifying in a subject sample whether UDP-glucuronosyltransferase 2B10 (UGT2B10) and/or... Agent: The Penn State Research Foundation

20110223594 - Methods, kits and compositions for determining severity and survival of heart failure in a subject: The application provides a method of determining a severity of heart failure in a human test subject, by determining a level of RNA encoded by one or more heart failure marker genes in blood of the test subject compared to controls. The application also provides a method of determining survival... Agent: Genenews Inc.

20110223592 - Multiple fluorophore detector system: A detector oligonucleotide comprises multiple pairs of a donor fluorophore and a quencher molecule, which donor fluorophores and quencher molecules are separated by a site that is capable of being cleaved when in double-stranded form. The detector oligonucleotide may be made double-stranded in a manner that depends on the presence... Agent:

20110223596 - Multiplex detection compositions, methods, and kits: The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in... Agent: Life Technologies Corporation

20110223599 - Parasite detection via endosymbiont detection: The present invention provides systems, methods, and compositions for identifying a subject as infected with a parasite by detecting nucleic acid from an endosymbiont of the parasite in a sample from the subject. In certain embodiments, the parasite is a nematode that infects humans or dogs (e.g., D. immitis, O.... Agent: Ibis Biosciences, Inc.

20110223593 - Predicting a response to olanzapine: The invention relates generally to the relative effect of specific genetic polymorphisms in predicting the clinical outcome of olanzapine therapy in patients suffering from a psychiatric disease such as schizophrenia.... Agent: Optimal Medicine Ltd.

20110223595 - Standardized and optimized real-time quantitative reverse transcriptase polymerase chain reaction method for detection of mrd in leukemia: The invention relates to in a real-time quantitative reverse transcriptase polymerase chain reaction (RQ-PCR) method for minimal residual disease detection in leukemic patients through amplification of a fusion gene transcript, the improvement comprising: (i) selecting amplifiable and qualified patient samples for subsequent analysis; (ii) defining optimal conditions for performing the... Agent: Universite De La Mediterranee

20110223602 - Systems and methods for multiplex analysis of pcr in real time: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable... Agent: Luminex Corporation

20110223604 - Assay for the measurement of igf type 1 receptor and insulin receptor expression: This invention relates to a quantitative PCR assay that differentiates between IR-A, IR-B and IGF-IR mRNAs and compares expression of the three receptors on the same scale.... Agent:

20110223605 - Multiple-sample microfluidic chip for dna analysis: Aspects of the disclosure provide a microfluidic chip. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain for electrophoretic separation. The first domain includes at least a first reaction reservoir designated for PCR amplification based on a first... Agent: Lockheed Martin Corporation

20110223606 - Nucleic acid quantitation from tissue slides: This invention provides methods of quantitating nucleic acids from problematic samples, such as aged samples, formalin fixed samples, paraffin embedded samples, samples with aneuploid cells, and cells with fragmented nucleic acids. Methods include techniques to efficiently solubilize the nucleic acids under non-denaturing conditions from preserved clinical samples without resort to... Agent: Panomics, Inc.

20110223607 - Circulating microrna as a marker for hepatocellular carcinoma: Provided herein are methods for the diagnosis, or management of liver diseases, e.g., hepatocellular carcinoma, using profiles of the miRNAs determined from cellular or acellular body fluids.... Agent: Quest Diagnostics Investments Incorporated

20110223608 - Molecular detection and quantification of enterococci: A primer pair and probe for the large subunit ribosomal RNA gene of enterococci for use in a real-time nucleic acid sequence based amplification (NASBA) assay.... Agent: University Of South Florida

20110223609 - Gene defects and mutant alk kinase in human solid tumors: In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated... Agent: Cell Signaling Technology, Inc.

20110223610 - Two secretory luciferases: The present invention is one gene construct or a combination of two gene constructs or expression vectors incorporating a Cypridina luciferase gene and a copepod luciferase under the control of distinct promoters. These gene constructs and expression vectors are useful for making a mammalian cell incorporating the Cypridina luciferase gene... Agent:

20110223611 - Lenalidomide and thalidomide immunoassays: Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and lenalidomide in biological fluids.... Agent:

20110223612 - Magnetic sensor based quantitative binding kinetics analysis: Methods for quantitatively determining a binding kinetic parameter of a molecular binding interaction are provided. Aspects of embodiments of the methods include: producing a magnetic sensor device including a magnetic sensor in contact with an assay mixture including a magnetically labeled molecule to produce a detectable molecular binding interaction; obtaining... Agent:

20110223613 - Method of imaging by mass spectrometry and new mass tag associated trityl derivatives: The present invention concerns a method of analyzing at least one specific molecule in a sample using a compound of formula (I″) wherein Z binds specifically to said at least one specific molecule, Y is independently a cleavable single bond, linker atom or group, and R is independently a substituent... Agent: Commissariat A L'energie Atomique Et Aux Energies Alternatives (cea)

20110223615 - Rapid expression cloning of human monoclonal antibodies from memory b cells: The present application provides methods for producing human monoclonal antibodies without using hybridoma technology, antibodies produced used the described methods, and methods for using the antibodies to treat or prevent disease conditions (e.g., infection by pathogens such as the Human Immunodeficiency Virus).... Agent: University Of Maryland, Baltimore

20110223614 - Toxin detection method: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus... Agent: Denka Seiken Co., Ltd.

20110223618 - Assays using chimeric t1r polypeptide: This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable... Agent:

20110223619 - Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use: Combinations of PI3K inhibitor compounds having Formulas I and II and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment... Agent: F. Hoffmann-la Roche Ag

20110223620 - Method of detecting microorganisms and microorganism detecting apparatus: It is possible to determine the presence of bacteria in a sample solution in a shorter period of time without changing a conventional incubating method. Bacteria in a sample solution are incubated in, for example, a sterilized agar medium 10 having a layer thickness of 0.1 μm to 1 μm... Agent: Nihon Dempa Kogyo Co., Ltd.

20110223616 - Hur-associated biomarkers: The present invention relates to methods of identifying gene targets, including methods of using ribonucleoprotein (RNP) immunoprecipitation-microarrays to identify cancer gene targets, such as subsets of RNP-associated mRNAs in breast cancer cell lines. Also presented, are ribonucleotide binding protein-associated biomarkers, panels or sets of ribonucleotide binding protein-associated biomarkers, methods and... Agent: The Curators Of The University Of Missouri

20110223617 - Immunoassays for autoantibodies in cardiovascular diseases: The present invention relates to the quantitative measurement of auto-reactive antibodies in a patient sample. In particular, the present invention is directed to, inter alia, a method for predicting the degree of cardiovascular injury in a patient following an ischemic event, said method comprising: immobilizing anti-NMHC II antibody on a... Agent:

20110223621 - Combinations for the treatment of immunoinflammatory disorders: The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.... Agent:

20110223622 - Methods and kits for predicting the onset of labour: The present invention relates to methods and kits useful for predicting the time of onset of labour in a pregnant subject. In particular, the invention relates to methods and kits for predicting the time of onset of labour wherein the levels of at least two hormones, selected from estriol, estradiol... Agent: Newcaste Innovation Limited

20110223623 - Methods for diagnosing cancer and determining the overall survival and disease-free survival of cancer patients: The invention provides methods for prognosis of patients afflicted with cancer, comprising determining the level of GP88 expression in a biological sample obtained from said patient.... Agent: A&g Pharmaceutical, Inc.

20110223624 - Immunoassay for detection of neurotoxic amino acid associated with neurological disorders: An immunoassay for screening a sample to detect the presence of β-N-methylamino-L-alanine (BMAA) is disclosed. Antibodies specific for BMAA are disclosed. Antibodies that bind to BMAA on immunoblots are disclosed. Immunoassays and kits to detect the presence of BMAA in a sample by contacting the sample with an antibody that... Agent: The Institute For Ethnomedicine

20110223625 - Bioluminescent assays using cyanobenzothiazole compounds: The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules, and/or the activity of such enzymes. The methods are adaptable to high-throughput... Agent: Promega Corporation

20110223626 - Method for quantitatively determining cholesterol in low-density lipoproteins,reagent for quantitative determination,and quantitative determination kit: A method for measuring cholesterol in low-density lipoprotein contained in a sample, which comprises reacting a sample with (i) a combination of cholesterol ester hydrolase and cholesterol oxidase or (ii) a combination of cholesterol ester hydrolase, an oxidized coenzyme and cholesterol dehydrogenase in the presence of: [a] a polyoxyethylene-polyoxyalkylene alkylaryl... Agent: Kyowa Medex Co., Ltd.

20110223627 - Microfluidic flow assay for measuring hemostatic phenotypes: A microfluidic-based flow assay and methods of manufacturing the same are provided. Specifically, the microfluidic flow assay includes a micropatterned surface that induces clot formation and an array of microfluidic channels though which blood flows. The micropatterned surface contains two clotting stimuli, one for inducing platelet adhesion and another for... Agent:

20110223628 - Method for the identification of a risk for a thrombogenic disorder by determining the tafl-lle347 polymorphism: The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk... Agent: Sanofi-aventis Deutschland Gmbh

20110223629 - Method for determination of delta-d values of non- exchangeable hydrogen stable isotopes on ethanol' s methyl group by means of irms instrumental technique: The present innovation is related with chemical instrumental analysis, i.e. to the domain of analysis of stable isotopes in food products, and it is related to the method for preparation of ethanol samples and mode for determination of isotopic ratio of non-exchangeable hydrogen stable isotopes sited on the methyl site... Agent:

20110223630 - Method for screening for compounds that inhibit neurodegeneration: Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage... Agent:

20110223631 - Detection of microorganisms with a fluorescence-based device: A device and method for detecting by fluorescence microbial growth from sample substances are disclosed. For example, a method for the detection of visible-band fluorescence signals generated by at least one fluorescing compound excited by ultraviolet energy, comprising exciting said at least one fluorescing compound with ultraviolet energy emitted from... Agent: Centrus International, Inc.

20110223632 - Smear staining apparatus, smear preparing apparatus, smear processing system, and method for determining staining condition: A smear staining apparatus comprising: a staining section which stains a smear sample with a quantity of stain fluid; and a controller, wherein the controller: receives information regarding a stain state on a smear sample which is stained according to a first staining condition by the staining section; and determines... Agent: Sysmex Corporation

20110223633 - Methods and reagents for enrichment and characterization of phosphorylated biomolecules: An affinity matrix comprising a metal ion covalently attached thereto and methods for making and using the same are described. The matrix has affinity for various phosphorylated biomolecules, such as phosphoproteins/phosphopeptides. The matrix may be used in a variety of different applications, including phospho-biomolecule (e.g., phosphoprotein and phosphopeptides) enrichment/purification and... Agent:

20110223636 - Fluorescent protein and chromoprotein: It is an object of the present invention to provide a novel fluorescent protein and a novel chromoprotein. The present invention provides a novel fluorescent protein derived from Montipora sp., Acropora sp. and Lobophytum crassum, and a novel chromoprotein derived from Actinia equine.... Agent: Medical & Biological Laboratories Co., Ltd.

20110223635 - Method and composition for controlling gene expression: A composition for expressing a protein in cells is provided. In certain embodiments, a circular expression vector provided herein comprises: a promoter, a coding sequence encoding a protein of interest, in which the coding sequence is in a reversed 3′-5′ orientation, a transcription termination sequence, and at least a first... Agent:

20110223634 - Transfection kinetics and structural promoters: The invention features methods of analyzing the kinetics properties of transfection reactions. Also featured are methods for creating structural promoters which are effectively unregulated by enhancers and repressors. The structural promoters are significantly more active than the native promoter sequences upon which they are based.... Agent: Alnylam Pharmaceuticals, Inc.

20110223637 - Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol: The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2... Agent: Genomatica, Inc.

20110223638 - Methods of generating nucleic acid fragments: Provided herein are methods of using a Cas1 polypeptide to generate nucleic fragments from a DNA substrate. These methods may be performed in vitro or in vivo. Also provided are methods of screening for modulators of Cas1.... Agent:

20110223639 - Process for conversion of granular starch to ethanol: The present invention concerns a method of producing glucose from a granular starch substrate comprising, contacting a slurry comprising granular starch obtained from plant material with an alpha-amylase at a temperature below the starch gelatinization temperature of the granular starch to produce oligosaccharides and hydrolyzing the oligosaccharides to produce a... Agent: Genencor International, Inc.

20110223640 - Improved statin production: The present invention provides a method for the fermentative production of compactin, lovastatin, pravastatin or simvastatin comprising culturing a host, preferably a filamentous fungus, comprising the polynucleotide of the lovE transcription regulator gene from Aspergillus terreus. Furthermore, the invention provides a host for the production of above mentioned statines comprising... Agent:

20110223641 - Microbial engineering for the production of fatty acids and fatty acid derivatives: Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to... Agent: Massachusetts Institute Of Technology

20110223642 - Method for inhibiting bacteria growth during ethanol fermentation: The present invention is an antibacterial hop product used to inhibit the growth of gram positive bacteria in yeast propagators and ethanol producing fermenters. The hop product is an isomerized or stabilized hop made of alkaline earth metals or alkali earth metals. The antibacterial hop product also enhances the alcohol... Agent:

20110223643 - System for bionic catalytic hydrolyzing cellulose and its use in producing liquid fuel from cellulose biomass: A bionic catalyst for hydrolyzing cellulose and hemicellulose and its preparation method. The catalyst comprises double acid radical catalytic portions and cellulose-linking portions, and can be used under room temperature and high temperature. The catalyst can hydrolyze cellulose and hemicellulose simultaneously, while not decompose glucose and xylose, and may be... Agent: China Fuel (huaibei) Bioenergy Technology Developm

20110223644 - Device for fuel and chemical production from biomass-sequestered carbon dioxide and method therefor: A process and apparatus for sequestering carbon and converting it to fuel, such as methane, and/or materials, such as fermentation substrates, biopolymers, bioplastics, oils, pigments, biochar, metals, such as mercury, chromium and arsenic, fibers, proteins, vitamins, fertilizers and animal feed. The apparatus comprises a deep well carbon-sequestering bioreactor coaxially located... Agent:

20110223645 - Multivalent carriers of bi-specific antibodies: Provided herein are targetable constructs that are multivalent carriers of bi-specific antibodies, i.e., each molecule of a targetable construct can serve as a carrier of two or more bi-specific antibodies. Also provided are targetable complexes formed by the association of a targetable construct with two or more bi-specific antibodies. The... Agent: Immunomedics, Inc.

20110223648 - Directed evolution of grg31 epsp synthase enzyme: Compositions and methods for conferring herbicide resistance or tolerance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include polynucleotides encoding herbicide resistance or tolerance polypeptides, vectors comprising those polynucleotides, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in DNA constructs... Agent:

20110223646 - Expression of soluble, active eukaryotic glycosyltransferases in prokaryotic organisms: The present invention provides enhanced methods of producing soluble, active eukaryotic glycosyltransferases in prokaryotic microorganisms that have an oxidizing environment.... Agent: Biogenerix Ag

20110223647 - Grg36: novel epsp synthase gene conferring herbicide resistance: Compositions and methods for conferring herbicide resistance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions include nucleic acid molecules encoding herbicide resistance or tolerance polypeptides, vectors comprising those nucleic acid molecules, and host cells comprising the vectors. The nucleotide sequences of the invention can be used in... Agent:

20110223649 - Recombinant cell transformed by an arabidopsis thaliana atpase athma1 sequence: This invention corresponds to a bacteria or preferably a yeast, which in its natural state presents a reduced tolerance to heavy metals, but when genetically transformed following this invention, with a vegetal-origin gene, presents high tolerance to heavy metals. Specifically, the cell in the invention is transformed with a vector... Agent:

20110223650 - Modular membrane reactor and process for carbon dioxide extraction: The present invention relates to a reactor and a process suitable for extracting carbon dioxide from carbon dioxide-containing gas stream. The reactor is based on a two module system where absorption occurs in one module and desorption occurs in the other module. The carbon dioxide extraction may be catalyzed by... Agent: Novozymes A/s

20110223651 - Apparatus for testing electrical activity from a biological tissue sample: An apparatus (100) for testing electrical activity from a biological tissue sample comprises a body (1) provided with a well (4), stimulating means (8) for stimulating a sample located in the well (4), and detecting means (9) for detecting electrical activity in the sample. In one embodiment the apparatus has... Agent: Kerr Scientific Instruments Limited

20110223653 - Method and apparatuses for sorting objects in forensic dna analysis and medical diagnostics: The present invention relates to an apparatus and method of sorting objects and identifying the objects in a forensics sample, including using holographic optical trapping to sort objects from contaminants, and performing (single cell) PCR-based STR analysis on the objects to determine their identification. In addition, the chip used as... Agent: Arryx, Inc.

20110223652 - Piezoelectric-based nanopore device for the active control of the motion of polymers through the same: Apparatus, system, and methods are provided for utilizing piezoelectric material for controlling a polymer through a nanopore. A reservoir is formed filled with conductive fluid. A membrane is formed that separates the reservoir. A nanopore is formed through the membrane. The membrane comprises electrical conductive layers, piezoelectric layers, and insulating... Agent: International Business Machines Corporation

20110223654 - Nano-microfluidic apparatus for continuous real-time analysis of targets in thin liquid films: Nano-microfluidic devices and uses thereof are described. In particular, systems and methods are described for continuous real-time monitoring and analysis of targets in thin liquid films; such targets can include living cells and tissues. In some embodiments, nano-microfluidic devices can be utilized to observe living cells in layers of thin... Agent:

20110223655 - System for measuring and analyzing properties of water and sediment samples: A system for assessing the characteristics and toxicity of a water sample comprising: a test chamber; an optical signal generator configured to emit an optical signal into the test chamber; a first digital filter disposed between the optical signal generator and the test chamber; a first optical transducer disposed to... Agent:

20110223656 - Micrornas and uses thereof: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of... Agent: Rosetta Genomics

20110223657 - Trp/his exchange and kynurenin induced trp transport: The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present... Agent:

20110223658 - Monoclonal antibodies with enhanced adcc function: The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease... Agent: Lfb Biotechnologies

20110223659 - Compositions and methods for detecting severe acute respiratory syndrome coronavirus: The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.... Agent: Diagnostic Hybrids, Inc.

20110223660 - Compositions for inducing differentiation into retinal cells from retinal progenitor cells or inducing proliferation of retinal cells comprising wnt signaling pathway activators: Disclosed is a composition for inducing the proliferation of retinal cells or the differentiation of retinal progenitor cells into retinal cells. The composition, similar to in vivo conditions for development during embryogenesis, induces stem cells to differentiate into a multitude of photoreceptor cells at high yield within a short period... Agent: Snu R&db Foundation

20110223661 - Inhibitors of stat3: Disclosed herein are compounds derived from a chemical structure according to the formula (I) wherein X comprises oxygen or sulfur, R1 comprises a phenyl or naphthyl group, R2 comprises an amide group and R3 comprises a phosphate group. The disclosed compounds demonstrate inhibitory activity against STAT3, a protein found in... Agent: University Of Central Florida Research Foundation,

20110223662 - Composition for preserving platelets and method of using the same: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally,... Agent: Biovec Transfusion, LLC

20110223663 - Composition for preserving platelets and method of using the same: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally,... Agent: Biovec Transfusion, LLC

20110223666 - Cytoplasm exposure additive and method for exposing particles delivered into cell to cytoplasm from endocytic vesicles in intact cell: The present invention relates to a method of exposing particles to cytoplasm comprising introducing particles into a live cell; allowing the live cell to contact a cytoplasm exposure additive which can expose the particles from endocytic vesicles to cytoplasm in the cell with maintaining its physiological, biochemical, or biological environment... Agent: Mediscov Inc.

20110223665 - Enhancement of sirna silencing activity using universal bases or mismatches in the sense strand: One aspect of the present invention relates to a double stranded nucleic acid useful as an siRNA, that has a sense strand and an antisense strand relative to a target nucleic acid, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with... Agent: Alnylam Pharmaceuticals, Inc.

20110223664 - Materials and methods of introducing genetic material into living cells: The present invention generally relates to introducing genetic material to living cells. In some embodiments, the present invention relates to compositions of matter for targeted delivery of nucleic acids to cells. In other embodiments, the present invention relates to methods of targeted delivery of nucleic acids to cells. In still... Agent: The University Of Akron

20110223667 - Metabolic engineering of lipid metabolism by improving fatty acid binding and transport: CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided.... Agent: The Salk Institute For Biological Studies

20110223668 - Method of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc): The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) and/or progeny derived therefrom in vitro or in vivo comprising exposing the MPC or progeny to SDF-1 or analog thereof. The invention also relates to compositions comprising isolated MPCs or progeny derived therefrom and... Agent: Angioblast Systems, Inc.

20110223669 - Method of efficiently establishing induced pluripotent stem cells: The present invention provides a method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells, comprising inhibiting the p53 function in the step of somatic cell nuclear reprogramming. The inhibition of p53 function is achieved by bringing a substance selected from the group consisting of (1) chemical... Agent: Kyoto University

20110223670 - Ets2 and mesp1 generate cardiac progenitors from fibroblasts: A method for modulating cell differentiation capabilities using heterologous gene expression. Some embodiments of the invention relate to a method for inducing a cardiac progenitor cell by delivering a reprogramming factor to the cell, wherein the reprogramming factor comprises ETS2 or a combination of ETS2 and Mesp1.... Agent: The Texas A&m University System

20110223671 - Methods for using positively and negatively selectable genes in a filamentous fungal cell: The present invention relates to methods for using positively and negatively selectable genes in a filamentous fungal cell to delete, disrupt, or insert a gene in a filamentous fungal cell.... Agent: Novozymes, Inc.

  
09/08/2011 > 92 patent applications in 53 patent subcategories. class, title,number

20110217689 - Fluidics based pulsatile perfusion preservation device and method: In one embodiment, a preservation apparatus is described that includes a storage compartment. The storage compartment is configured to hold an organ or tissue and a preservation fluid. A cover assembly is configured to engage the storage compartment. The cover assembly includes a support element, wherein the support element together... Agent: Board Of Regents, The University Of Texas Systems

20110217690 - Interconnected bioreactors: A method of combining the content of bioreactors allowing homogeneous mixing in accordance with CFR21 is described that allows processing of variable size batches using a single validated bioreactor is described.... Agent: Therapeutic Proteins Inc

20110217691 - Oxygen-assisted fermentation process: A fermentation process uses substantially pure oxygen. The oxygen is the only reactive gas which is injected into a fermentation vessel. The oxygen is moved through the vessel solely by its own pressure. The process can be used with both mechanically-agitated and air-lifted fermenters. The mechanically-agitated fermenter includes an analyzer... Agent: Air Liquide Industrial U.s. Lp

20110217692 - Photobioreactors, solar energy gathering systems, and thermal control methods: The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a prototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a... Agent:

20110217695 - Betag1-igg intron for enhanced anti-igf1r expresson: The present invention provides polynucleotides for enhanced expression of a target gene such as an immunoglobulin. Methods of expressing a target gene using the polynucleotides of the invention are also covered.... Agent: Schering Corporation

20110217694 - Flow cytometry-based systems and methods for detecting microbes: In various embodiments, the present disclosure describes methods and systems for detecting microbes in a sample. The methods are generally applicable to quantifying the number of target bacteria in a sample counted from a detection region of a flow cytometer histogram. The detection methods can be employed in the presence... Agent:

20110217693 - Generation of replication competent viruses for therapeutic use: The present invention relates to the generation of replication-competent viruses having therapeutic utility. The replication-competent viruses of the invention can express proteins useful in the treatment of disease.... Agent: Bayer Schering Pharma Ag

20110217696 - Aza-benzazolium containing cyanine dyes: Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when... Agent: Life Technologies Corporation

20110217699 - Fluorescent chemical compounds having high selectivity for double stranded dna, and methods for their use: Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can... Agent: Life Technologies Corporation

20110217698 - Method to improve single molecule analyses: The quality of information from single molecule analyses is improved by employing a method in which a single molecule reaction carried out within an optical confinement is monitored, the single molecule reaction is halted, and data from the optical confinement is obtained while the reaction is not occurring. Characteristic optical... Agent: Pacific Biosciences Of California, Inc.

20110217697 - Methods and apparatus for measuring analytes using large scale fet arrays: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and... Agent: Life Technologies Corporation

20110217700 - Methods of seed breeding using high throughput nondestructive seed sampling: The present invention provides for novel methods to facilitate germplasm improvement activities through the use of high throughput, nondestructive sampling of seeds. A method for analyzing a population of haploid seeds generally includes providing a population of seeds comprising haploid seeds, removing tissue samples from a plurality of the seeds... Agent: Monsanto Technology LLC

20110217709 - Detection of chromsomal region copy number changes to diagnose melanoma: This invention provides methods of detecting melanoma. The methods comprises detecting a gain or loss of certain chromosomal regions that undergo copy number changes in melanoma.... Agent: The Regents Of The University Of California

20110217707 - Evaluation/screening method for diseases associated with d-amino acid utilizing da01-/-mouse: Disclosed is an evaluation method which can rapidly discriminate a Dao−/− homozygote from a large number of animals produced in a mating experiment between a DAO enzyme deficient mouse and other disease model mice, to rapidly perform a quantitative measurement of the D-amino acids contained in a large number of... Agent: Shiseido Company Ltd

20110217706 - Gene methylation in cancer diagnosis: DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer are provided Additionally, methods of identifying differentially methylated DNA biomarker sequences and their use for the detection and diagnosis of cancer are provided.... Agent:

20110217704 - Lepa/guf1 gene sequences as a diagnostic target for the identification of bacterial species: The current invention relates to a diagnostic kit for a bacterial species and/or fungal and/or yeast species comprising at least one oligonucleotide probe capable of binding to at least a portion of the LepA and/or Guf1 genes or its corresponding mRNA.... Agent: National University Of Ireland, Galway

20110217708 - Methods and compositions for detecting colon cancers: This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.... Agent: Case Western Reserve University

20110217705 - Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids: Methods and materials for determining the presence of at least one nucleic acid in a sample are provided, said methods comprising (1) a purification step using sequence specific hybrid capture; (2) an amplification step; and (3) a detection step using two separate sequence-specific polynucleotide probes. Also provided are nucleic acids... Agent: Qiagen Gaithersburg Inc.

20110217702 - Methods for diagnosis of and predicting treatment efficacy of hormone receptor expressing tumors, cancers and neoplasias: The invention relates to diagnosis, detection, screening, identifying and predicting methods. In various embodiments, methods of the invention include diagnosis, detection, or screening for a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in the subject; identifying a subject that will or is likely to respond to a therapy for... Agent: Esperance Pharmaceuticals

20110217703 - P2/p2a/p2b gene sequences as diagnostic targets for the identification of fungal and yeast species: The present invention relates to nucleic acid primers and probes to detect one or more fungal and yeast species. More specifically the invention relates to the P2, P2A and P2B gene sequences (also known as 60S acidic ribosomal protein P2, RLA-2-ASPFU, Allergen ASP f8 or Afp2), the corresponding RNA, specific... Agent: National University Of Ireland Galway

20110217701 - Prognostic marker for endometrial carcinoma: The present invention relates to a method for diagnosis of different stages of endometrial cancer in an individual. Further, the present invention relates to a method for evaluating the probability of survival for an individual suffering from endometrial carcinoma. In another aspect, the present invention relates to the stratification of... Agent:

20110217711 - Assays with droplets transformed into capsules: System, including methods, apparatus, compositions, and kits, for assays with an emulsion including capsules. A method of performing an assay is provided. In the method, an aqueous phase may be provided. The aqueous phase may include a sample and an effective concentration of one or more skin-forming proteins. An emulsion... Agent: Quantalife, Inc.

20110217713 - Biomarkers for the identification, monitoring, and treatment of non-small cell lung cancer (nsclc): This present invention compositions and methods of treating, diagnosing, prognosing cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound.... Agent: On-q-ity

20110217712 - Emulsion chemistry for encapsulated droplets: System, including methods, apparatus, compositions, and kits, for making and using a stabilized emulsion. A method of generating a stabilized emulsion is provided. In the method, an aqueous phase may be provided. The aqueous phase may include an effective concentration of one or more skin-forming proteins. An emulsion may be... Agent: Quantalife, Inc.

20110217714 - Full cold-pcr enrichment with reference blocking sequence: The present invention is directed to methods, compositions and software for enriching low abundance alleles in a sample. It is directed in particular to the use of an excess amount of reference blocking sequence in an amplification reaction mixture in order to improve the enrichment efficiency, and reduce cycle time,... Agent: Dana-farber Cancer Institute, Inc.

20110217715 - Gene expression in duchenne muscular dystrophy: Gene expression in peripheral blood from individuals with Duchenne muscular dystrophy (DMD), compared to control individuals, demonstrated differential gene sets that could be used in a method to diagnose DMD, to evaluate effect of DMD therapy, and/or to evaluate propensity to DMD.... Agent: The Regents Of The University Of California

20110217716 - Method for quantifying skin changes caused by six external evils and method for screening skin condition-improving materials using the same: Disclosed herein are a method for quantifying skin changes caused by six external evils and a method of screening skin condition-improving materials using the quantification method. More specifically, disclosed are a method of measuring cellular changes caused by external stimuli in a skin cell culture system, in which the degree... Agent:

20110217710 - Methods for genotyping: The present invention provides for methods for discriminating between alleles at polymorphic positions in a genome. In general the methods employ allele specific extension of oligonucleotides that are complementary to one of the alleles at the 3′ end of the oligonucleotide. The allele specific oligonucleotides are resistant to proof reading... Agent: Affymetrix, Inc.

20110217717 - Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells: The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for... Agent:

20110217718 - Methods and kits for distinguishing between specific and non-specific protein associations: The present invention is method of determining whether or not associations between a given protein and other proteins in a cell are specific. The method comprises (a) providing a first sample of the cells in which the given protein contains a tag, (b) providing a second sample of the same... Agent: The Rockefeller University

20110217719 - Methods and kits for diagnosing obstructive sleep apnea: The presently-disclosed subject matter provides methods and kits for diagnosing obstructive sleep apnea (OSA) in a subject, such as a human child, wherein a biological sample is provided from the subject and the amount of a Urocortin III peptide is determined from the sample. Further provided are methods for diagnosing... Agent: University Of Louisville Research Foundation, Inc.

20110217720 - Compositions and kits pertaining to analyte determination: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.... Agent:

20110217725 - Cell culture kit, screening method, and method of manufacturing cell culture kit: To provide a cell culture kit including cultured living cells of various donors, and a manufacturing method thereof. The cell culture kit includes a culture plate and living cells cultured thereon. The culture plate includes a plurality of microchambers (33) and living cells derived from various donors are adhered to... Agent: Public University Corp. Yokohama City University

20110217723 - Epi-illumination apparatus and methods for sorting particles: A method and apparatus for sorting stained particles in a fluid stream, each of the method and apparatus including an epi-illumination optics system with a focusing lens. The optics system being operable to direct a beam of electromagnetic radiation through the focusing lens in a forward direction along a beam... Agent: Inguran, LLC

20110217726 - Method and kit for detecting biological signal of three-dimensional cell culture material: Disclosed is a method for detecting a biological signal of a three-dimensional cell culture construct. The method for detecting a biological signal of a three-dimensional cell culture construct includes: providing a three-dimensional cell culture construct that contains at least two cell layers laminated to each other and a sensor particle... Agent: Japan Science And Technology Agency

20110217727 - Method for patterning magnetic materials in live cell, method for imaging pattern of magnetic materials, and apparatus used for same: The present invention provides a method for imaging a pattern of magnetic materials in a live cell comprising: preparing a plurality of magnetic materials magnetized in a direction of a line of magnetic force by applying a magnetic field, at least one of the magnetic materials being configured into a... Agent: Mediscov Inc.

20110217724 - Method of protecting cells: Provided is a method for protecting stem cells in a clinical graft against destruction induced by the complement system by adding to the graft at least one factor capable of inhibiting the complement. Also provided is a method for protecting stem cells in a clinical graft against destruction induced by... Agent: Suomen Punainen Risti Veripalvelu

20110217722 - Photo-damage apparatus and methods for sorting particles: A system and method for sorting a mixture of stained particles in a fluid flow path, including stained particles from two distinguishable groups. The system and method can include an electromagnetic radiation source for exciting fluorescence emissions from the stained particles, a photodetector for detecting the fluorescence emissions from the... Agent: Inguran, LLC

20110217721 - Water soluble fluorescent quantum carbon dots: The present invention relates to the water soluble self fluorescent quantum carbon dots (C-dots). These C-dots are isolated from carbon soot in one embodiment a wax soot solvent washed and isolated from other larger material by filtration such as by membrane filtration. The C-dots can be varied in their color... Agent:

20110217728 - High throughput test method for evaluation of biocides against anaerobic microorganisms: Provided is a high-throughput method for determining the biocidal efficacy of biocidal agents against anaerobic organisms. The method includes the steps of: providing one or more anaerobe samples in a first set of multiple receptacles accessible to multi-channel pipettes; providing one or more biocidal samples at known concentration(s) in a... Agent:

20110217730 - Systems and methods for analyzing and manipulating biological samples: A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the... Agent: Yissum Research Development Company Of The Hebrew University Of Jerusalem

20110217729 - Targeted cell separation and enumeration device and the use thereof: This disclosure describes a portable device that conveniently applies cancer patient blood sample into a test strip to determine the level of the patient's metastatic circulating tumor cells. Proper use of this device provides end users with the diagnostic and prognostic information of the cancer patient, and any effect of... Agent:

20110217731 - Pathology sample processing workstation: A pathology sample processing workstation. The samples are positioned on containers having RFID tags and processed at stations having RFID transceivers coupled to a computer. Information regarding the samples can stored on the RFID tags and retrieved using the transceivers.... Agent: Mayo Foundation For Medical Education And Research

20110217732 - Method and compositions for the detection of protein glycosylation: The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits... Agent: California Institute Of Technology

20110217734 - Compositions and methods for the synthesis of appa-containing peptides: The disclosure of the present application provides polypeptide sequences and nucleotide sequences coding for the polypeptide sequences of proteins used in the production of APPA-containing peptides. In at least one embodiment of the present disclosure, an isolated nucleic acid is disclosed which comprises a nucleotide sequence encoding a polypeptide having... Agent:

20110217733 - Expanding the eukaryotic genetic code: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic... Agent: The Scripps Research Institute

20110217735 - Compositions and methods for reverse transcriptase-polymerase chain reaction (rt-pcr): The present invention is directed to compositions and methods useful for the amplification of nucleic acid molecules by reverse transcriptase-polymerase chain reaction (RT-PCR). Specifically, the invention provides compositions and methods for the amplification of nucleic acid molecules in a simplified one- or two-step RT-PCR procedure using combinations of reverse transcriptase... Agent: Life Technologies Corporation

20110217736 - System for hot-start amplification via a multiple emulsion: System, including methods, apparatus, compositions, and kits, for making and using compound droplets of a multiple emulsion to supply an amplification reagent, such as a heat-stable DNA polymerase or DNA ligase, to an aqueous phase in which the compound droplets are disposed. The compound droplets may be induced to supply... Agent: Quantalife, Inc.

20110217737 - High processivity polymerases: Chimeric proteins comprising a sequence nonspecific single-stranded nucleic-acid-binding domain joined to a catalytic nucleic-acid-modifying domain are provided. Methods comprising contacting a nucleic acid molecule with a chimeric protein, as well as systems comprising a nucleic acid molecule, a chimeric protein, and an aqueous solution are also provided. The joining of... Agent:

20110217738 - Methods and devices for nucleic acid synthesis: Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary embodiments, the device includes a support having a plurality of features. Each feature contains a plurality of oligonucleotides. Within each feature, each of the plurality of oligonucleotides includes an identical predetermined... Agent: Gen9, Inc.

20110217739 - Cas6 polypeptides and methods of use: Provided herein are methods for cleaving a target RNA polynucleotide. The target RNA polynucleotide includes a Cas6 recognition domain and a cleavage site, and may be based on a repeat from a CRISPR locus. The methods may be practiced in vivo or in vitro. Also provided are polypeptides that have... Agent: University Of Georgia Research Foundation, Inc.

20110217740 - Methods, microorganisms, and compositions for plant biomass processing: Disclosed herein are methods of degrading plant biomass, and microorganisms and polypeptides used in such methods, hi certain embodiments, the methods include growing Anaerocellum thermophilum on a substrate that comprises plant biomass under conditions effective for the A. thermophilum to convert at least a portion of the plant biomass to... Agent: University Of Georgia Research

20110217741 - Enhanced promoter and method for producing l-lysine using the same: The present invention provides a nucleic acid molecule having enhanced promoter activity, which is operably linked to a gene encoding aspartate aminotransferase and derived from Corynebacterium glutamicum, a vector comprising the nucleic acid molecule, a transformant transformed with the vector, and a method for producing L-lysine using the transformant.... Agent: Cj Cheiljedang Corporation

20110217742 - Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce... Agent:

20110217743 - Method of producing lauric acid-containing oil or fat: e

20110217744 - Use of sucrose as substrate for fermentative production of 1,2-propanediol: The present invention is relative to a method for producing 1,2-propanediol by fermentation, comprising: cultivating a microorganism producing 1,2-propanediol in an appropriate medium comprising a source of sucrose, and recovering the 1,2-propanediol being produced, wherein the microorganism is able to utilize sucrose as sole carbon source for the production of... Agent: Metabolic Explorer

20110217745 - Enhancement of enzymatic hydrolysis of pre-treated biomass by added chitosan: A process for producing a fermentation product from a lignocellulose-containing material includes pre-treating the lignocellulose-containing material; introducing chitosan or a chitosan-like polymer to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to an effective amount of a hydrolyzing enzyme; and fermenting with a fermenting organism to produce a fermentation... Agent: Novozymes North America, Inc.

20110217746 - Fermentation process starting from cellulosic biomass and involving the recirculation of detoxified stillage into the process: A method for preparing a target chemical derivable from cellulosic biomass, involving detoxification of spent hydrolysate is provided. The method comprises the steps of providing cellulosic biomass, subjecting the cellulosic biomass to aqueous pretreatment, aqueous hydrolysis, and fermentation under conditions in which at least a part of the fermentable sugars... Agent: Sekab E-technology Ab

20110217747 - Landfill methane enhancement process: A zero-discharge landfill process is disclosed herein. The process described in the present invention recycles the exhaust gases from a combustion engine which reheats the landfill and provides moisture. Additionally, the CO2 from the exhaust gases releases additional methane. Methane production in landfills can thus be enhanced by the method... Agent: Board Of Regents, The University Of Texas System

20110217748 - Algal cell lysis and lipid extraction using electromagnetic radiation-excitable metallic nanoparticles: According to one embodiment, the disclosure provides a system for algal cell lysis. The system may include at least one algal cell, a plurality of metal nanoparticles, and an electromagnetic radiation generator. The generator may be able to generate radio frequency or microwave radiation that excites the plurality of metal... Agent: Raytheon Company

20110217749 - Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions: The method for the cultivation of primary cells may be one step in a method for the amplification of viruses, such as poxviruses. According to this latter method the primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and... Agent: Bavarian Nordic A/s

20110217751 - Alginate microbeads, method for forming the same and associated applications: This present invention relates to a method for forming alginate microbeads. The method includes using a needle connected to a vibrator to continuously spot tiny alginate microdroplets in an oil layer. Subsequently, the temporarily formed alginate microdroplets sink into a CaCl2 solution to become gelled microbeads. As a whole, the... Agent: National Cheng Kung University

20110217750 - Dendrimers and dendrimer applications: An activatable functionalised Nth generation dendrimer having: a core comprising a first monomer having at least two carboxylic acid functional groups; and N successive generations, where N=0 to 10, wherein each generation comprises: a second monomer having at least two alcohol functional groups, wherein at least one alcohol group is... Agent: National University Of Ireland, Galway

20110217752 - Ligand functionalized polymers: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.... Agent: 3m Innovative Properties Company

20110217753 - Inhibitors of extracellular proteases: Provided is a plant derived extract including inhibitory activity against one or more extracellular proteases which degrade human tissue matrix. Moreover, the amount of inhibitory activity in an extract can be increased by stressing the plant prior to forming an extract. These extracts are each prepared by a process and... Agent: Biopharmacopae Design International Inc.

20110217754 - Ketoreductase polypeptides for the production of (r)-3-hydroxythiolane: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.... Agent: Codexis, Inc.

20110217755 - Variant form of urate oxidase and use thereof: The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.... Agent: Savient Pharmaceuticals, Inc.

20110217756 - Newly isolated bacteriophage specific to klebsiella pneumoniae: A newly isolated lytic bacteriophage specifically against Klebsiella pneumoniae, deposited at DSMZ-Deutsche Sammlung von Mikroorganismen and Zellkulturen with deposit number (DSM 24329), shows broad host ranges and lytic effects on K. pneumoniae isolated from Taiwan under either in vivo or in vitro models.... Agent:

20110217757 - Modified vaccinia ankara virus variant and cultivation method: The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a... Agent: Bavarian Nordic A/s

20110217760 - Sporulation-deficient thermophilic microorganisms for the production of ethanol: A thermophilic microorganism comprising a modification that prevents sporulation, wherein the modification inactivates the native spo0A gene.... Agent: Tmo Renewables, Limited

20110217758 - Incorporation of thermo-resistant and/or pressure-resistant organisms in materials: The present application relates to methods for producing materials having viable micro-organisms incorporated therein. More particularly, the materials are produced under high temperature and/or high pressure conditions, and the microganisms are incorporated in the material before or during these conditions. Also provided are micro-organisms that remain viable under these conditions... Agent: Resilux

20110217759 - Strains of bacteria and pharmaceutical composition containing one or more of such strains and use of same for preventing and treating diseases associated with or caused by altered metabolism of bile acids: Strains of bacteria characterized by exhibiting: (a) a 7α-dehydroxylase activity of less than 50%, and (b) a bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of... Agent:

20110217761 - Method for processing peroxygen solutions: The present disclosure relates to a multi-step method for processing peroxygen solutions for reuse or disposal. The method uses an enzyme and a reducing agent.... Agent: Ecolab Usa Inc.

20110217763 - A semiconductor for measuring biological interactions: An apparatus and method are disclosed for electrically directly detecting biomolecular binding in a semiconductor. The semiconductor can be based on electrical percolation of nanomaterial formed in the gate region. In one embodiment of an apparatus, a semiconductor includes first and second electrodes with a gate region there between. The... Agent:

20110217762 - Photo-acoustic detection device and method: An example method for detecting an analyte in a sample of a bodily fluid comprises the steps of exposing the bodily fluid sample to electromagnetic energy to cause a thermoelastic expansion in the analyte, and detecting a photoacoustic signal in the sample that results from the thermoelastic expansion.... Agent: The Curators Of The University Of Missouri

20110217764 - Rotating bioreactor and spool harvester apparatus for biomass production: An apparatus that exposes a biofilm growth surface to liquid media as it rotates. A biofilm growth substratum is wound around a rotatable body in the form of a non-rigid material capable of supporting biofilm growth. A harvester receives the biofilm laden substratum, collects the biofilm as a biomass and... Agent: Utah State University

20110217765 - Device for a liquid lock for a fermentation receptacle for biological material: A liquid lock is for a fermentation receptacle for production of biogas, the liquid lock being provided as an annular liquid filled vessel encircling an upper portion of the receptacle wall(s), an inner portion of a fabric being fastened to the receptacle, an edge portion of a receptacle cover encircling... Agent:

20110217766 - Methods of producing peptides in plants and peptides produced thereby: Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein)... Agent: Ohio University

20110217770 - Cell piercing device and method of using same: A cell piercing device comprising a container, a respectively matching cap and a cell interacting surface is disclosed. The cell interacting surface comprises a plurality of extensions or prongs. The cell piercing device may further comprise a pedestal. Furthermore, a method of facilitating an interaction with the interior of cells... Agent:

20110217769 - Cell-type specific aptamer-sirna delivery system for hiv-1 therapy: The present invention relates to compositions and methods for delivery of siRNA to specific cells or tissue. More particularly, the present invention relates to compositions and methods for cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer.... Agent: City Of Hope

20110217771 - Fluidic culture device: A fluidic culture device (100) comprises a substrate (101) of transparent polymer material with an open culture chamber (110) in the form of a hollow in a bottom surface (102) of the substrate (101). Open fluid channels (120, 130) flank the culture chamber (110) and have inlets (140, 150) and... Agent:

20110217768 - Novel lipase: The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus Tetrasphaera, as well as a gene encoding the same. This lipase has the ability to recognize a medium-chain fatty acid as a substrate. The present... Agent: Suntory Holdings Limited

20110217767 - Single-use stationary bioreactors and mixing vessels: Stationary bioreactors and mixing vessels fitted with single-use flexible bags utilizing wave hydrodynamic principle are described for use in every type of biological process and products.... Agent:

20110217772 - Animal protein free media for cultivation of cells: The present invention relates to animal protein free cell culture media comprising a combination of non-animal derived peptides derived from soy hydrolysate and yeast hydrolysate. The invention also provides an animal protein free culture process, wherein cells are cultivated, propagated and passaged without animal-derived components. This process is useful for... Agent: Baxter Healthcare S.a.

20110217773 - Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro: The present invention provides a method for restoring native chondrocyte phenotype and functions of, and/or increasing type II collagen as well as aggrecan mRNA expression levels and GAG accumulation level in dedifferentiated chondrocytes which have been subcultured and expanded in vitro, which comprising culturing the said dedifferentiated chondrocytes in vitro... Agent: Taipei Medical University

20110217774 - Efficient and universal method for neural differentiation of pluripotent stem cells: The present invention relates to a method for inducing neural differentiation of stem cells. In more detail, the present invention relates to a method for inducing neural differentiation of stem cells by inhibiting both BMP (bone morphogenetic protein) and Activin/Nodal signaling pathways in the stem cells. The present invention allows... Agent: Industry-academic Cooperation Foundation Yonsei University

20110217775 - Methods for modulating osteochondral development using bioelectrical stimulation: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or... Agent: Medrelief Inc.

20110217777 - Process for the extraction of lipids from microalgae using ionic liquids: The invention relates to use of an active ionic liquid to dissolve algae cell walls. The ionic liquid is used to, in an energy efficient manner, dissolve and/or lyse an algae cell walls, which releases algae constituents used in the creation of energy, fuel, and/or cosmetic components. The ionic liquids... Agent:

20110217776 - Transcription factor gene osnacx from rice and use thereof for improving plant tolerance to drought and salt: The present invention relates to an isolated polynucleotide capable of giving a plant tolerance to drought and/or salt stress, which comprises a polynucleotide sequence as shown in SEQ ID NO:1, and to a promoter capable of giving a plant tolerance to drought and/or salt stress. The present invention also relates... Agent: Huazhong Agricultural University

20110217778 - Leader sequence to boost gene expression: The invention provides compositions and methods for enhanced gene expression. The invention provides a composition comprising a 28-codon leader sequence operably linked to a desired gene which encodes the desired protein.... Agent: The Trustees Of The University Of Pennsylvania

20110217779 - Compositions and methods for non-targeted activation of endogenous genes: The present invention is directed generally to activating gene expression or causing over-expression of a gene by non-homologous or illegitimate recombination, of a regulatory sequence that causes expression of the gene. Thus, by the present invention, endogenous genes, including those associated with human disease and development, may be activated and... Agent: Abt Holding Company

20110217780 - Transgenic algae engineered for higher performance: The present disclosure relates to transgenic algae having increased growth characteristics, and methods of increasing growth characteristics of algae. In particular, the disclosure relates to transgenic algae comprising a glutamine phenylpyruvate transaminase transgene and to transgenic algae comprising a glutamine phenylpyruvate transaminase transgene and a glutamine synthetase... Agent: University Of Maine System Board Of Trustees

  
09/01/2011 > 100 patent applications in 54 patent subcategories. class, title,number

20110212431 - Fluidics based pulsatile perfusion preservation device and method: In one embodiment, a preservation apparatus is described that includes a storage compartment. The storage compartment is configured to hold an organ or tissue and a preservation fluid. A cover assembly is configured to engage the storage compartment. The cover assembly includes a support element, wherein the support element together... Agent:

20110212432 - Separation of blood cells from a blood sample:

20110212433 - Alcohol production process: The invention relates to the production of products such as alcohols and acids by microbial fermentation, particularly microbial fermentation of substrates comprising CO. It more particularly relates to methods and systems for improving efficiency of production products by microbial fermentation. In particular embodiments, the invention provides a method of controlling... Agent: Lanza Tech New Zealand Limited

20110212435 - Antimicrobial compounds: The compounds disclosed herein are isoxazole derivatives that are useful as antimicrobial compounds, particularly as anti-bacterial compounds. The disclosed methods comprise incubating at least two different substrates in the presence of at least one oxygenase to provide the disclosed compounds, or to prepare and identify compounds that have antimicrobial activity.... Agent:

20110212434 - Novel hiv-based recombinant viral clones and use thereof in analytical methods: e

20110212440 - Cell sorting device: An integrated microsystem, comprising: a microchannel, a field generator to create a magnetic field in at least one first portion of the microchannel having a direction substantially collinear with the direction of flow in the portion of the microchannel, the magnetic field also presenting a gradient, wherein the microsystem additionally... Agent: Fluigent

20110212439 - Hla alleles associated with adverse drug reactions and methods for detecting such: This invention relates to a method of determining the presence of certain HLA alleles, such as HLA-B*1502 or HLA-B*5801, and a kit for carrying out this method. Also disclosed is a method for assessing whether a patient is at risk for developing adverse drug reactions (e.g., Stevens-Johnson syndrome, toxic epidermal... Agent: Pharmigene Inc.

20110212438 - Kits and devices for performing methods of detecting viability-associated molecules: Kits and devices for performing a method of detecting a molecule associated with viability of one or more cells or organisms in a sample are provided. The method comprises the initial step of contacting the sample with an enzyme, which enzyme is capable of adding or removing a chemical moiety... Agent: Iseao Technologies Limited

20110212436 - Molecular redundant sequencing: Methods, systems and compositions where a target nucleic acid includes a registration sequence disposed therein for identification of the number or relative position of determined sequence from the template sequence. Particularly preferred aspects include a registration sequence in a circular template nucleic acid sequence which is, in turn, used in... Agent: Pacific Biosciences Of California, Inc.

20110212437 - Single molecule sequencing with two distinct chemistry steps: Methods, Compositions, and Systems are provided for nucleic acid sequencing where the sequential incorporation of nucleotides uses two distinct chemical steps. A plurality of nucleotide analogs, each having a labeled leaving group at its 3′ hydroxyl can be sequentially added to a growing strand in the presence of a selective... Agent: Pacific Biosciences Of California, Inc.

20110212449 - Distinguishing pca3 messenger rna species in benign and malignant prostate tissues: This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer... Agent:

20110212446 - Fast pcr for str genotyping: Disclosed is a method of amplifying a nucleic acid sequence, wherein the method comprises subjecting a reaction mixture to at least one amplification cycle, wherein the reaction mixture comprises a double-stranded nucleic acid and at least two primers capable of annealing to complementary strands of the double-stranded nucleic acid and... Agent: Life Technologies Corporation

20110212448 - Gammacarboxyglutamate-rich protein, methods and assays for its detection, purification and quantification and uses thereof: The presently disclosed subject matter refers to a gammacarboxyglutamate-rich protein that shows in vivo a high capacity to bind calcium through specific gamma carboxylated glutamic acid residues (Gla). It includes a description of the referred protein, purification procedures, protein detection and quantification tools and methods. A kit for the detection... Agent:

20110212443 - Method for determining the specific growth rate of distinct microbial populations in a non-homogeneous system: The present invention pertains to a molecular biology-based method and kit for measuring the specific growth rate (or cell doubling time) of distinct microbial populations. The method and kit can be used to analyze mixed culture samples that have been exposed to chloramphenicol or other protein synthesis inhibitors for defined... Agent: University Of South Florida

20110212447 - Method of using foxo3a polymorphisms and haplotypes to predict and promote healthy aging and longevity: The invention provides methods and compositions relating to identification and use of genetic information from the FOXO3A gene that can be used for determining and increasing an individual's likelihood of longevity and of retaining physical and cognitive function during aging, and for determining and decreasing an individual's likelihood of developing... Agent:

20110212441 - Methods and systems for inferring bovine traits: Methods, compositions, and systems are provided for managing bovine subjects in order to maximize their individual potential performance and edible meat value, and to maximize profits obtained in marketing the bovine subjects. The methods and systems draw an inference of a trait of a bovine subject by determining the nucleotide... Agent: Cargill, Incorporated

20110212450 - Polarization-enhanced detector with gold nanorods for detecting nanoscale rotational motion and method therefor: A nanoscale motion detector attaches a gold nanorod (30) to the rotating arm (26) of a molecular structure (10) to cause the nanoparticle to rotate. The molecular structure is an F1-ATPase enzyme. The gold nanorod is exposed to a light source. The long axis of the gold nanorod scatters red... Agent: Arizona Board Of Regents For And On Behalf Of Arizona State University

20110212451 - Rna detection method: The present invention relates to methods for the detection of target RNA sequences and to RNA amplification methods making use of strand displacement techniques employing RNA-dependent RNA polymerases having RNA-oligonucleotide duplex separation activity and being capable of de novo RNA synthesis in the absence of a primer. The present invention... Agent: Riboxx Gmbh

20110212445 - Swi5 gene as a diagnostic target for the identification of fungal and yeast species: The invention relates to the SWI5 gene, the corresponding RNA, specific probes, primers and oligonucleotides related thereto and their use in diagnostic assays to detect and/or discriminate between fungal and yeast species.... Agent: National University Of Ireland, Galway

20110212442 - Universal nucleic acid probe set and method for utilization thereof: A nucleic acid probe set includes (A) a fluorescent probe and (B) a binding probe. The fluorescent probe (A) is formed of an oligonucleotide, which includes (a) a nucleotide unit labeled with (d) a fluorescent substance. The binding probe (B) is formed of an oligonucleotide having (b1) a fluorescent probe... Agent: Nippon Steel Kankyo Engineering Co., Ltd.

20110212444 - Use of methylation status of mint loci and tumor related genes as a marker for melanoma and breast cancer: The invention relates to a method of detecting melanoma or breast cancer using DNA methylation in MINT17, MINT31, or the promoter region of WIF1, TFPI2, RASSF1A, SOCS1, GATA4, or RARβ2 as a biomarker. Also disclosed are methods of using the biomarker for determining the cancer status and predicting the outcome... Agent:

20110212453 - Assay card for sample acquisition, treatment and reaction: The present disclosure relates to devices and systems and methods for their use for detecting an analyte. In particular, the present disclosure provides a disposable assay card in which reaction reagents are stored within the card to facilitate point-of-care application.... Agent:

20110212454 - Assay for telomerase activity: The invention is directed to methods for determining the level of telomerasc reverse transcriptase activity in mammalian cells.... Agent: Geron Corporation

20110212452 - Method for preparative production of long nucleic acids by pcr: The invention relates to a method for preparative production of long nucleic acids by PCR. The method involves the following hybridization steps: a) a nucleic acid base sequence is hybridized on the 3′ and 5′ ends with an adapter primer; b) the product from step a) is hybridized on the... Agent: Rina-netzwrk Rna-technologien Gmbh

20110212455 - Method of screening material for improving skin functions: That is to say, a material for improving skin functions is screened using MAP17 gene as a marker, on the basis of the change in the expression level of the MAP17 gene. A material for improving skin functions, which is useful in improving skin barrier function, promoting skin moisturization, preventing... Agent: Amorepacific Corporation

20110212456 - K-ras and b-raf mutations and anti-egfr antibody therapy: The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to B-raf mutations, to polynucleotides encoding mutant B-raf polypeptides, to vectors containing those polynucleotides, and to methods of identifying B-raf mutations. The present application also... Agent: Amgen

20110212457 - Methods and compositions for determining the pathogenic status of infectious agents: The present invention relates to methods and compositions for improved detection of infectious agents and microbes. In particular, the present invention provides novel methods for detecting infectious agents, providing information about the viability status of such infectious agents and for determining drug susceptibility. In certain embodiments, the present invention employs... Agent:

20110212458 - Methods for production of xylitol in microorganisms: The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates.... Agent: Biotechnology Research Development Corporation

20110212459 - Novel presenilin associated membrane protein (pamp) and uses thereof: Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment, mutations in PAMP are diagnostic for Alzheimer's Disease or spina bifida. The invention further relates... Agent: Governing Council Of The University Of Toronto

20110212460 - Assay for nitrous oxide neurologic syndrome: A method for detection of susceptibility to nitrous oxide neurologic syndrome in a subject is disclosed. In one embodiment, the method comprises: (a) providing a sample from a subject, wherein said subject is a candidate for nitrous oxide anesthesia; and (b) detecting the presence or absence of folate, cobalamin, methionine... Agent:

20110212463 - Hybrid target analyte responsive polymer sensor with optical amplification: Disclosed is a product that includes an optical sensor; a target-responsive hydrogel matrix on a surface of the optical sensor (where the hydrogel matrix comprises one or more target-specific receptors and one or more target analogs), and one or more high refractive index nanoparticles within the hydrogel matrix, where a... Agent: University Of Rochester

20110212464 - Pacap as a marker for cancer: The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the proapoptotic caspase adaptor protein (=PACAP) as a universal marker of different types of cancer. PACAP aids in the assessment of pulmonary or lung cancer (LC), particularly of non-small cell lung carcinoma... Agent:

20110212461 - Prediction of cardiotoxicity: The likelihood that a compound will exhibit cardiotoxicity in an in vitro or in vivo assay predicted by the ability of the compound to inhibit at least one kinase from a selected group.... Agent:

20110212462 - Ultra-sensitive detection of molecules using dual detection methods: Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods... Agent: Quanterix Corporation

20110212468 - Biomarkers and methods for determining disease progression in nonalcoholic steatohepatitis (nash): Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. Provided herein are biomarkers, methods, and animal models useful for the investigation and non-invasive detection of NASH, including a non-invasive biomarker that could be used to establish disease severity,... Agent:

20110212469 - Simultaneous assay of target and target-drug binding: Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding.... Agent:

20110212465 - Armet as a marker for cancer: Disclosed is a method aiding in the assessment of cancer. More specifically disclosed is the use of the arginine-rich metastasized in early tumors protein (=ARMET) as a universal marker of different cancer types. ARMET aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of... Agent:

20110212467 - Inhibitors of dutpase: Evidence demonstrating that elevated expression of dUTPase protects breast cancer cells from the expansion of the intracellular uracil pool, translating to reduced growth inhibition following treatment with 5-FU is provided. The implementation of in silica drug development techniques to identify and develop small molecule inhibitors of dUTPase are reported. As... Agent: University Of Southern California

20110212466 - Thiol-modified surface immobilization article and method: A method and article to immobilize a protein, including, for example, combining the protein and a mixture comprised of an activated spacer compound having a maleimide group in a buffer solution, to form a maleimide-modified protein; and contacting the maleimide-linker-modified protein and a buffer swollen, thiol-modified, surface bound polymer to... Agent:

20110212472 - Asbestos exposure, pleural mesothelioma and osteopontin levels: The present invention provides diagnostic and disease progression or recurrence prediction methods based on osteopontin levels in a biological sample.... Agent: Department Of Veterans Affairs

20110212470 - Biomarkers for rheumatoid arthritis: The present invention relates to the diagnosis of autoimmune disorders, more specifically to the diagnosis of rheumatoid disorders, chronic autoimmune arthritis and even more specifically to the diagnosis of rheumatoid arthritis. A biomarker panel is provided which can be used to detect if a subject has rheumatoid arthritis. Also described... Agent:

20110212471 - Method for diagnosing atherosclerotic plaques by measurement of cd36: The present invention relates to diagnosis, classification and monitoring of atherosclerotic plaques in an individual using measurement of the concentration of CD36 in a body fluid and/or the plaque as such. The present invention also relates to diagnosing the burden of atherosclerotic plaques in an individual. Furthermore, the invention relates... Agent:

20110212473 - Mmp activation peptide detection in biological samples: A method is provided along with related reagent kits for aiding the diagnosis of IPF or other interstitial lung diseases, as well as for potential monitoring of disease progression or therapeutic response to treatment.... Agent:

20110212474 - Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells: The present invention provides a method for the diagnosis of AD from non-AD conditions by using a PKC Isozyme Index obtained by determining ratios of ratios of different PKC Isozymes in peripheral cells of a test subject in the absence and presence of a beta-amyloid peptide, and optionally, in the... Agent: Blanchette Rockefeller Neurosciences Institute

20110212475 - Fluorescently or spin-labeled kinases for rapid screening and identification of novel kinase inhibitor scaffolds: The present invention relates to a kinase labeled at an amino acid having a free thiol or amino group, wherein said amino acid is naturally present or introduced in the activation loop of said kinase, with (a) a thiol- or amino-reactive fluorophore sensitive to polarity changes in its environment; or... Agent:

20110212476 - Genetically engineered g-alpha proteins and uses thereof: The present invention relates to novel engineered Ga proteins and assay methods of using such proteins to advance drug discovery. Engineered Ga proteins described by the invention contain alterations of at least one and preferably two or more amino acid residues that are highly conserved among all four subfamilies of... Agent:

20110212477 - Lipoprotein-associated markers for cardiovascular disease: The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop, or is suffering from, cardiovascular disease. The methods comprise detecting an amount of at least one biomarker in a biological sample, or HDL subfraction thereof, from the subject, and comparing the... Agent: University Of Washington

20110212478 - Catheter: A catheter for insertion into a blood vessel, the catheter having a sampling part arranged to capture a blood sample at a plurality of locations along a length of the blood vessel and an apparatus arranged to analyse blood taken from a plurality of locations along the length of the... Agent: Pa Knowledge Limited

20110212481 - Assays and methods for fusing cell aggregates to form proto-tissues: Provided are assays and methods for creating proto-tissues from aggregates of cells. The invention concerns assays and methods useful in tissue engineering and reconstruction techniques, specifically in the formation of macrotissues from microtissues using microtissue pre-culture time as a controlling parameter.... Agent:

20110212484 - In vitro model of focal ischemia: A method of modeling in vitro focal ischemia comprising: perfusing a tissue slice in vitro with an oxygenated medium; and, applying a focal insult to a targeted portion of the tissue slice. The method is particularly useful for brain tissue.... Agent:

20110212479 - Measurement of sequestered carbon: Disclosed herein are methods and systems for determining an amount of carbon dioxide that can he sequestered from the atmosphere by a portion of an ocean. The methods or systems involve the following steps (a) determining which chemical element or elements would, when added to a photic zone of the... Agent:

20110212482 - Methods and devices for sample collection, treatment and dispensing: A device for collecting, treating and dispensing a biological sample is described. Use of the device permits integration of sample collection, sample treatment, and sample dispensing.... Agent: Northwestern University

20110212483 - Methods and kits for the diagnosis of ryr1-related diseases: The present invention encompasses methods for diagnosis of calcium channel related diseases (e.g., RyR1-related diseases) comprising contacting lymphocytes isolated from a subject with a calcium channel agonist (e.g., an RyR1 agonist), measuring the adenosine and inosine produced by the lymphocytes; and comparing the measured levels in the sample to the... Agent:

20110212485 - System, method and device for tissue-based diagnosis: The current invention provides devices, methods and systems involving application of energy and/or a liquefaction promoting medium to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, tissue decontamination as well as qualitative and/or quantitative detection of analytes that... Agent: The Regents Of The University Of California

20110212480 - Use of primary human cardiomyocytes: The present invention provides for the use of primary human cardiomyocytes for the testing of agents that have cardiotoxic effects and other modulatory effects on the heart.... Agent:

20110212486 - Microscope system, specimen observation method, and computer program product: A microscope system includes an acquisition unit that obtains a specimen image acquired by capturing the specimen stained by an element identification dye that visualizes a predetermined cell constituent element and a molecule target dye that visualizes a predetermined target molecule by using a microscope; a dye amount unit that... Agent: Japanese Foundation For Cancer Research

20110212487 - Methods for producing charcoal and uses thereof: The present invention relates to methods for producing activated charcoal from lignocellulose-containing material residual solids and uses of the same.... Agent:

20110212488 - Immortalized avian cell lines and use thereof: The present invention relates to specific immortalized avian cell lines expressing telomerase reverse transcriptase (TERT), and exhibiting distinct biologics production patterns. More particularly, the present invention relates to immortalized avian cell line capable of either amplifying Flaviviridae but not capable of amplifying Vaccinia virus strain Copenhagen (W—COP) nor Modified Vaccinia... Agent: Transgene S.a.

20110212489 - Culture medium for eukaryotic cells: A proteolysate of a seed material derived from a plant species of the Asteraceae family, such as sunflower, has improved properties as a constituent of a culture medium for culturing eukaryotic, in particular animal cells. The seed material is defatted and is hydrolysed to a degree of 10-50% and subsequently... Agent: Campina Nederland Holding B.v.

20110212490 - Methods and compositions for performing low background multiplex nucleic acid amplification reactions: Methods and compositions for performing low background multiplex nucleic acid amplification reactions are provided. Aspects of the invention include contacting a nucleic acid sample with two or more primer pairs for two or more target nucleic acids under template dependent primer extension reaction conditions, e.g., polymerase chain reaction (PCR) conditions.... Agent:

20110212492 - Pcr method and pcr device: Provided on an inner surface of a container to carry out polymerase chain reaction (PCR) are an electrode pair 22 to be disposed to face each other with a gap along a flow of a reaction solution interposed therebetween, and an AC voltage is applied to the electrode pair 22... Agent: Fluid Incorporated

20110212491 - Reaction vessel: A reaction vessel for carrying out a chemical or biochemical reaction, such as a polymerase chain reaction, said vessel having a coating of parylene or a derivative thereof, on at least the surface which contacts reactants.... Agent: Enigma Diagnostics Limited

20110212494 - Method to quantify sirnas, mirnas and polymorphic mirnas: The present teachings provide methods, compositions, and kits for quantifying target, polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3′ end of a target polynucleotide, using a ligase that can ligate the 3′ end of RNA to the 5′ end of DNA using a DNA... Agent: Life Technologies Corporation

20110212493 - Perfusion bioreactors, cell culture systems, and methods for production of cells and cell-derived products: The present invention includes perfusion bioreactors, automated cell culture systems, and methods for production of cells and cell-derived products.... Agent: Biovest International, Inc.

20110212495 - Compartmentalized simultaneous saccharification and fermentation of biomass: Methods and apparatus' are disclosed for the simultaneous saccharification and fermentation of biomass providing for the compartmentalization of the saccharification process and the fermentation process resulting in decreased enzymatic end-product inhibition.... Agent: E.i. Du Pont De Nemours And Company

20110212496 - L-amino acid-producing microorganism and a method for producing an l-amino acid: An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has an L-amino acid-producing ability and inherently has a native activity of a glucose dehydrogenase that uses pyrroloquinoline quinone as a coenzyme, but has been modified so that the activity of the glucose dehydrogenase is... Agent:

20110212497 - Method for production of polylactate using recombinant microorganism:

20110212498 - Light-driven co2 reduction to organic compounds to serve as fuels or as industrial half products by an autotroph containing a fermentative gene cassette: A process of producing an organic compound and/or an intermediary compound as defined herein by feeding carbon dioxide to a culture of a cyanobacterial cell and subjecting the culture to light, wherein the cell is capable of expressing a nucleic acid molecule, wherein the expression of the nucleic acid molecule... Agent: Universiteit Van Amsterdam

20110212499 - Locally-regulated pressurized pretreatment of lignocellulosic biomass: Described are methods for pretreating lignocellulosic biomass that comprise passing a hot aqueous biomass slurry through a heat exchange passage from an inlet to an outlet and locally regulating pressure in the passage by feed of a pressurized liquid medium to one or more intermediate locations of the passage. Also... Agent:

20110212501 - 3-dimensional multi-layered hydrogels and methods of making the same: Embodiments of the invention provide three dimensional multi-layered hydrogel constructs with embedded channels, living cells and bioactive agents, and methods for making three dimensional multi-layered hydrogel constructs. The constructs can have bioactive agents to support the living cells. The multi-layered constructs can have channels for perfusion purposes and layers of... Agent: The Brigham And Women's Hospital, Inc.

20110212500 - Flow-stretch-flexure bioreactor: Described herein is a bioreactor system and modules capable of developing physiologically relevant fluid-induced shear stresses and regionally specific flow patterns to scaffold specimens and which can couple these stresses to cyclic flexure and/or stretch states. Methods of use of the bioreactor system and module also are provided.... Agent:

20110212503 - Method for designing heat-resistant tyrosine-dependent short-chain dehydrogenase/reductase and heat-resistant tyrosine-dependent short-chain dehydrogenase/reductase: A method for designing a heat-resistant mutant enzyme, the method including the step of reducing a distance between the α4 helix and the α6 helix in a protein three-dimensional structure to become smaller than that of a wild type enzyme through deletion, replacement, addition, or insertion of one or several... Agent: Sony Corporation

20110212502 - [nife]-hydrogenases having an improved resistance to dioxygen, process for obtaining them and their applications: The invention relates to [NiFe]-hydrogenases having an improved resistance to dioxygen, said [NiFe]-hydrogenases may be obtained by:—providing an initial polynucleotide comprising a sequence encoding a large subunit of a [NiFe]-hydrogenase, said large subunit comprising the following peptide motifs: L1: RGXE, wherein X=L, I, F, V or M L2: [R/K]X1C[G/R]X2C, wherein... Agent:

20110212504 - Recombinant expression of carboxylesterases: The present application provides a method of producing a carboxylesterase or its variant in eukaryotic cells. The present application also provides an expression vector for high level carboxylesterase expression, a eukaryotic cell comprising the expression vector, and uses thereof. The present application also provides a composition comprising a carboxylesterase or... Agent: Tongji University

20110212505 - Bgl3 beta-glucosidase and nucleic acids encoding the same: The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL3, recombinant BGL3 proteins and methods for producing the same.... Agent: Danisco US Inc.

20110212506 - Nitrile hydratase variant: A nitrile hydratase variant of the present invention comprises substitution of at least one amino acid with another amino acid to improve two or more properties of nitrile hydratase by substitution of one amino acid.... Agent: Mitsui Chemicals, Inc.

20110212507 - Methods for increasing product yields: A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing... Agent:

20110212508 - Novel synthetic expression vehicle: An expression vehicle comprising an isolated nucleic acid as shown in Seq ID No. 1 comprising of a synthetic hybrid promoter wherein the hybrid promoter comprises of an inducible arabinose promoter derived from E. coli and a synthetic stretch of 8-35 nucleotides from pHO regulon introduced in the region between... Agent:

20110212509 - Device for and method of extracting a fraction from a biological sample: A device and method are provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a phase-gate zone for receiving an isolation buffer therein.... Agent:

20110212510 - Polarization-enhanced detector with gold nanorods for detecting nanoscale rotational motion and method therefor: A nanoscale motion detector attaches a gold nanorod (30) to the rotating arm (26) of a molecular structure (10) to cause the nanoparticle to rotate. The molecular structure is an F1-ATPase enzyme. The gold nanorod is exposed to a light source. The long axis of the gold nanorod scatters red... Agent: Arizona Board Of Regents For And On Behalf Of Arizona State University

20110212511 - System for detecting biomolecule with high sensitivity using micro-cantilever: Provided is a protein detection system using a micro-cantilever and based on immune responses, wherein the micro-cantilever shows significantly improved sensitivity to allow detection of a trace amount of biomolecule. To the micro-cantilever, sandwich immunoassay is applied, and the sandwich immunoassay uses a polyclonal antibody or silica nanoparticles having a... Agent: Korea Institute Of Science And Technology

20110212512 - Monitoring network based on nano-structured sensing devices: A monitoring network system for inspecting and controlling harmful substances includes probe assemblies that each includes a sensor comprising nano structured surfaces or nano particles in a solution, configured to adsorb molecules of a sample material captured adjacent to the sensor, a laser that can emit a laser beam to... Agent:

20110212515 - Culture/exposure device, in particular for cell and/or bacteria cultures: In a culture/exposure device, in particular for cell and/or bacteria cultures, having receptacles (10, 12, 14) for culture containers (11, 13, 15) in a base body (4) and having a flow guide, which has an inlet (20), for supplying a test atmosphere to the culture container (11, 13, 15), it... Agent:

20110212513 - Isolator for cell culture: An isolator for cultivating cells including a working chamber having a plurality of gloves arranged side by side into which operator's hands are inserted to operate cells, the working chamber being sectioned into at least an operation area for operating the cells, and an auxiliary working area for opening a... Agent:

20110212514 - Method and apparatus for disrupting cells and amplifying nucleic acids using gold nanorods: Provided is a method of disrupting cells comprising adding gold nanorods to a solution containing cells and irradiating the gold nanorods with a laser to disrupt the cells. A method and an apparatus for continuously disrupting cells and amplifying nucleic acids in a single microchamber are also provided, wherein the... Agent: Samsung Electronics Co., Ltd.

20110212516 - Flow-based thermocycling system with thermoelectric cooler: Thermocycling system, including methods and apparatus, for performing a flow-based reaction on a sample in fluid. The system may include a plurality of segments defining at least two temperature regions, and also may include a plurality of heating elements configured to maintain each temperature region at a different desired temperature.... Agent:

20110212517 - Method and device for preparing a sample of biological origin in order to determine at least one constituent contained therein: The invention relates to a method of preparing an original sample (3) of biological origin with a view to detecting at least one component contained in it, whereby the original sample (3) is enclosed in a first container (1) and at least a part of this original sample (3) is... Agent:

20110212521 - Apparatus and method for generating a tool motion: The invention relates to an apparatus according to the present invention for generating the motion of a tool, in particular for the work on biological cell material, in particular for performing ICSI, comprises at least one actuator element, an actuated member, a motion section, at which can be arranged a... Agent: Eppendorf Ag

20110212519 - Compartmentalized device for cell culture, cell processing and sample dialysis: A versatile compartmentalized cell culture device, with a selectively permeable membrane separating the compartments, provides many attributes relative to traditional devices. It can be configured for high-density cell culture, co-culture, and sample dialysis while rolling or standing still. It can also be configured for continuous movement of liquid between compartments.... Agent:

20110212518 - Expression vector and methods of producing high levels of proteins: A process for high expression of protein of interest using an expression vector. The process comprises at least the following regulatory elements: a) a CMV promoter, or its functional variants, b) an intron, c) TPL or its functional variants, d) VA genes or functional variants, and e) a bovine growth... Agent: Cadila Healthcare Limited

20110212522 - Micro-chamber processing apparatus for cell culture and method: This invention relates to a method and apparatus for process cell cultures. The apparatus comprises a micro-chamber comprising no more than one absorption layer and at least one gel layer, in this order, laminated on a transparent base plate having no conspicuous absorbency in visible and infrared regions, and at... Agent:

20110212520 - Rna interference suppression of neurodegenerative diseases and methods of use thereof: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.... Agent: University Of Iowa Research Foundation

20110212523 - Differentiation-inducing culture medium additive and use thereof: Provided is a differentiation-inducing culture medium additive for inducing bone differentiation of at least one type of cell selected from the group consisting of a stem cell, a dental pulp cell, a periodontal ligament cell, a placenta, an amnion, and a fibroblast under a serum-free condition, and a use of... Agent:

20110212524 - Biomaterial and preparation method thereof: A method for preparing a biomaterial comprising the steps of acellularizing the fish scale to remove cell components, decalcifying the fish scale; and cleaning the fish scale, wherein in the step of acellularizing, it further including stirring constantly the fish scale in a solution comprised of an octylphenoxypolyethoxyethanol, a tris-buffered... Agent: Body Organ Biomedical Corporation

20110212525 - Method and apparatus for substantially isolating plant tissues: The present invention provides methods and devices for the rapid isolation of monocot plant embryos suitable for transformation or tissue culture. The invention includes mechanical devices for substantially isolating plant embryos for use as transformable explants. Media suitable for isolating plant embryos and methods for their preparation are also provided.... Agent:

20110212526 - Method for producing recombinant adeno-associated virus: A method of producing recombinant adeno-associated virus (rAAV) including the following steps of cotransducing host cells with a transduction solution comprising recombinant baculovirus carrying genes of the rAAV, and culturing the cotransduced host cells in a medium.... Agent: National Tsing Hua University

20110212527 - Method to increase the production of extracellular polymeric substances (eps) in a acidithiobacillus ferrooxidans culture by the inhibition of enzymes of tricarboxilic acid cycle: A method of increasing the production of extracellular polymeric substances (EPS) in an Acidithiobacillus ferrooxidans culture is disclosed. The method includes inhibiting an enzyme, such as citrate synthase, aconitase, or isocitrate dehydrogenase, in the tricarboxylic acid (TCA) cycle leading to alpha-ketoglutarate.... Agent: Biosigma S.a.

20110212528 - Novel substitution mutant receptors and their use in an ecdysone receptor-based inducible gene expression system: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a... Agent:

20110212530 - Method of targeted gene delivery using viral vectors: Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic... Agent: California Institute Of Technology

20110212529 - Muscle-specific expression vectors: The invention is directed to novel combinations of muscle-specific enhancers and promoter elements useful for achieving persistent expression in the muscle or myocyctes. The muscle-specific promoter elements are derived from a muscle creatine kinase promoter, a troponin I promoter, a skeletal alpha-actin promoter, or a desmin promoter. The muscle-specific enhancer... Agent:

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