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Chemistry: molecular biology and microbiology August inventions list 08/11Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 08/25/2011 > 116 patent applications in 67 patent subcategories. inventions list
20110207112 - Automated system for cryopreservation of oocytes, embryos, or blastocysts: An automated system and method of cryopreservation and reanimation of oocytes, embryos, or blastocysts is disclosed. One or more oocytes or embryos are positioned in a processing container, the processing container being configured to allow fluid to flow into and out of the processing container, where two or more fluids... Agent: Mariposa Biotechnology, Inc
20110207111 - Metabolic rate indicator for cellular populations: Described and claimed is a novel system and method for monitoring the metabolic rate of a cellular population in an industrial process. The invention includes obtaining a sample of the cellular population and initiating a reaction between a metabolic component of the cellular population and a bioreporter. The reaction produces... Agent:
20110207114 - Amplified fluorescence polymers and sensor thereof: The present disclosure is related to amplified fluorescence polymers (AFPs) with pendant functional groups, their derivatives and their synthesis. The amplified fluorescence polymers can be used in various biological and chemical sensors.... Agent: Bigtec Private Limited
20110207113 - Protein structure and method of using protein structure: Methods for building an atomic model of a protein molecule that include: (a) identifying a protein molecule with at least 20% sequence identity to Microsomal Prostaglandin E Synthase 1 (MPGES1) and (b) utilizing the atomic coordinates of MPGES1 to obtain an atomic model of the identified protein molecule are provided.... Agent: Novasaid Ab
20110207115 - Methods and materials for detecting contaminated food products: This document provides methods and materials for detecting contaminated food products. For example, methods and materials for using an enzymatic amplification cascade of restriction endonucleases to detect nucleic acid of a microorganism or virus (e.g., a pathogen) within a sample (e.g., food product sample) being tested, thereby assessing a food... Agent:
20110207118 - Dna template tailoring using pna and modified nucleotides: Disclosed is a method whereby a repetitive nucleic acid sequence, such as a short tandem repeat (STR), may be characterized as to its length. Pyrosequencing is used to sequence an STR repetitive region to measure the length of STRs in a rapid manner. A combinatorial approach is disclosed for the... Agent: The Regents Of The University Of California
20110207117 - Generation of production strains that efficiently express nuclear transgenes: The present invention relates to a method of generating eukaryotic cells suitable for the expression of transgenes in said cells comprising (a) introducing a nucleic acid encoding a selectable marker responsive to a selecting agent into the nucleus of cells, wherein the level of expression of said selectable marker is... Agent:
20110207119 - Methods for predicting a cancer patient's response to sunitinib: The present invention provides methods for individualizing chemotherapy for cancer treatment, and particularly for evaluating a patient's responsiveness to sunitinib prior to treatment. The method comprises expanding malignant cells in culture from a patient's tumor specimen, contacting the cultured cells with one or more active agents including sunitinib, and evaluating... Agent:
20110207121 - Sample processing device for pretreatment and thermal cycling: A sample processing device may include an opening, a sample pretreatment unit, a thermal cycling reaction unit, and a detection unit.... Agent: Chen & Chen, LLC
20110207116 - Spatio-temporal control of protein interactions using phytochromes: The invention provides methods, materials and systems of regulating association between proteins of interest using light. In an aspect, the invention takes advantage of the ability of phytochromes to change conformation upon exposure to appropriate light conditions, and to bind in a conformation-dependent manner to cognate proteins called phytochrome-interacting factors.... Agent: The Regents Of The University Of California
20110207120 - Wnt1 as a renal damage biomarker: The present invention comprises the use of WNT1 as a biomarker in the monitoring, prognosis and/or in the diagnosis of chronic nephropathies. It provides in vitro prognostic and diagnostic methods and kits for its implementation. The present invention also comprises the use of WNT1 in screening active ingredients for the... Agent: Hospital Clinic I Provincial De Barcelona
20110207133 - Binding and functional assays that use the t1r3 receptor to screen for taste modulatory compounds: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent:
20110207126 - Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination: This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in... Agent: University Of Chicago
20110207124 - Genetic alterations associated with autism and the autistic phenotype and methods of use thereof for the diagnosis and treatment of autism: Compositions and methods for the detection and treatment of autism and autistic spectrum disorder are provided.... Agent:
20110207127 - Markers for detection of legionella pneumophila strains: The invention relates to a method of detecting Legionella pneumophila strains by hybridizing genomic DNA of a sample suspected to contain Legionella to one or morespecific sequence markers, as identified by SEQ ID NO:1 through SEQ ID NO:10 or homologues thereof or in an immunoassay with antibodies specifically recognizing the... Agent: Nederlandse Organisatie Voor Toegepast-natuurwetenschappellijk
20110207123 - Method for detecting chromosomal abnormalities: The invention relates to an in vitro method for detecting chromosomal abnormalities in a mammal, comprising the in situ hybridization of n chromosomes from a metaphase chromosome preparation with sets of a plurality of nucleic acids, each set hybridizing, over a length of 700 000 to 3 000 000 contiguous... Agent:
20110207122 - Method for determination of progression risk of glaucoma: A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base... Agent: Santen Pharmaceutical Co., Ltd.
20110207125 - Method for labelling a product using a plurality of polynucleotides, method for identifying the labelling and labelled product: A method for labeling a product includes a step of adding on or in the product a plurality of single-stranded polynucleotides, which plurality of polynucleotides includes at least one target polynucleotide constituted of a single-stranded polynucleotide of predetermined length and sequence, and decoy polynucleotides which have identical or different predetermined... Agent: Bioquanta Corp.
20110207130 - Method of detecting tumor-associated hypermethylated dna in plasma or serum: This invention relates to detection of specific extracellular nucleic acid in human or animal blood plasma or serum associated with disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA including non-mutated hypermethylated DNA, and to methods of detecting and monitoring extracellular... Agent: The Penn State Research Foundation
20110207128 - Methods and kits for determining biological age and longevity based on gene expression profiles: Described herein are methods of predicting the likelihood of survival in a subject. Additionally, described herein are methods of modulating survival in a subject.... Agent:
20110207129 - Methods of diagnosing non-urinary tract diseases by detecting aberrant methylation: Provided are methods of diagnosing and/or determining treatment of non-urinary tract cancers by detecting biomarkers, and aberrant methylation in said biomarkers, in human urine samples... Agent: Philadelphia Health & Education Corporation D/b/a Drexel University College Of
20110207135 - Methods of monitoring conditions by sequence analysis: The invention is directed to methods of generating sequence profiles of populations of nucleic acids, whose member nucleic acids contain regions of high variability, such as populations of nucleic acids encoding T cell receptors or B cell receptors. In one aspect, the invention provides pluralities of sets of primers for... Agent: Sequenta, Inc.
20110207134 - Monitoring health and disease status using clonotype profiles: There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using DNA sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune... Agent: Sequenta, Inc.
20110207131 - Multiplex amplification and detection: The invention relates to the field of multiplex amplification. In particular, the invention relates to methods for assaying a sample for one or more nucleic acid targets in a single reaction based on the distinct melting temperatures or melting profiles of primers and/or probes. The invention also provides probes and... Agent:
20110207132 - Probes and methods for detecting analytes: Embodiments disclosed herein relate generally to probes, methods, and kits for detecting the presence of a target analyte. The probe generally comprises two strands that have regions of complementarity and do not associate with each other at the reaction temperature. In the presence of an analyte, the two strands of... Agent: University Of Maryland
20110207136 - Detection of micro metastasis of melanoma and breast cancer in paraffin-embedded tumor draining lymph nodes by multimarker quantitative rt-pcr: The invention provides a quantitative realtime RT-PCR assay for detection of metastatic breast, gastric, pancreas or colon cancer cells or metastatic melanoma. The assay allows to predict disease recurrence and survival in patients with AJCC stage I and II, and III disease using multimarker panels. The method for detecting metastatic... Agent: John Wayne Cancer Institute
20110207143 - Diagnostic test for mutations in codons 12-13 of human k-ras: The invention is directed to compositions, methods and kits for diagnosing cancers and tumors correlated with mutations in codons 12 and 13 of human K-RAS using primers that amplify target sequences. The amplified target sequences are then analyzed by any number of mass spectrometric techniques, which data are queried against... Agent: Abbott Laboratories
20110207141 - Differential gene expression in physiological and pathological angiogenesis: Methods of inhibiting pathological angiogenesis in a subject are disclosed. In particular examples, the method includes administering a therapeutically effective amount of a composition to a subject wherein the composition includes a specific binding agent that preferentially binds to one or more pathological angiogenesis marker proteins including Vscp, CD276, ETSvg4... Agent: National Institutes Of Health
20110207142 - Fluorometer with low heat-generating light source: This invention concerns a fluorometer preferably combined with a thermal cycler useful in biochemical protocols such as polymerase chain reaction (PCR) and DNA melting curve analysis. The present fluorometer features a low heat-generating light source such as a light emitting diode (LED), having a one-to-one correspondence to each of a... Agent:
20110207137 - Methods for measuring samples using consumer electronic devices and systems: Methods for measuring and analyzing biological or chemical samples using consumer electronic devices and systems are described. Moreover, an accessory to enable using devices such as cell phones and smartphones with fluidic illumination chambers are described.... Agent:
20110207140 - Microfluidic system for amplifying and detecting polynucleotides in parallel: The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept... Agent:
20110207138 - Multiplex amplification reaction method for determination of campylobacter jejuni penner/capsule type: The inventive method and associated reagents relate to a molecular approach to determining Campylobacter jejuni capsule/Penner types. The invention also relates to a method of identifying Campylobacter jejuni types using the inventive primers in a multiplex PCR assay.... Agent:
20110207139 - Restriction endonucleases and their applications: Provided is a methylation-specific restriction endonuclease for a DNA duplex substrate, which endonuclease recognizes in a strand of the duplex a 2 to 6 nucleotide recognition sequence comprising a 5-methylcytosine, and cleaves each strand of the duplex at a fixed position outside the recognition sequence.... Agent: Fermentas Uab
20110207144 - In vitro screening assays: Disclosed herein are methods for identifying inhibitors of the catalytic activity of LOXL2 using in vitro assays. In certain embodiments, inhibitors identified by these in vitro assays are effective in inhibiting tumor desmoplasia and fibrosis.... Agent:
20110207145 - Methods and compositions for detecting receptor-ligand interactions in single cells: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The... Agent:
20110207146 - Methods and compositions for detecting receptor-ligand interactions in single cells: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The... Agent:
20110207147 - Compositions and methods for modification of biomolecules: Provided are modified cycloalkyne compounds; and methods of use of such compounds in modifying biomolecules. Embodiments include a cycloaddition reaction that can be carried out under physiological conditions. The cycloaddition reaction involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The... Agent:
20110207149 - Methods and compositions for risk stratification: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in... Agent:
20110207150 - Cell assay kit and method: A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or... Agent:
20110207151 - Utilisation de ferrofluides pour le phenotypage sanguin et applications derivees: The invention relates to a method for phenotyping blood and/or performing an irregular agglutinin test and/or for determination of compatibility of a donor and receiver, using an aqueous solution of ferrofluid, obtained from a mixture of polyoxoanions of Fe(III) and at least one metal M(II) of oxidation state II. The... Agent:
20110207156 - Biomarkers for diagnosis of breast cancer: The present invention provides methods and kits for determining breast cancer. The invention includes the identification and use of biomarkers that are present in different amount or differentially expressed in breast cancer versus normal controls.... Agent: The Regents Of The University Of Colorado
20110207152 - Gelsolin binding agent compositions and uses of same: The invention relates generally to gelsolin binding agents (e.g., antibodies) which can bind to gelsolin polypeptides. Gelsolin binding agents of the invention are useful, alone or in combination, to detect a gelsolin polypeptide (a.k.a., the target polypeptide) in a test sample as well as to purify native gelsolin proteins. Gelsolin... Agent:
20110207154 - Method for determination of marinobufagenin levels and compounds employable in such method: The present invention is directed toward a method for determination of marinobufagenin concentration in a body specimen through conjugation of marinobufagenin to a suitable protein, thereby creating a conjugate which will trigger an antibody response in a host. The conjugated marinobufagenin is immunogenic. The antibodies so produced may be employed... Agent: Scott & White Healthcare
20110207155 - Method for the preparation of immunoconjugates and use thereof: The present invention concerns a method for the preparation of molecular conjugates comprising immunoglobulins and biomarkers occurring in neoplastic diseases characterized by high levels of reproducibility.... Agent: Xeptagen Spa
20110207153 - Methods for detecting the presence of expanded cgg repeats in the fmr1 gene 5' untranslated region: The invention provides improved methods for detecting the presence of expanded CGG repeats in the fragile X mental retardation 1 (FMR1) gene and for quantifying the amount of protein produced by the gene.... Agent: The Regents Of The University Of California
20110207157 - Labelling of fusion proteins with synthetic probes: The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to these ACTs and to fusion proteins comprising these. The substrates according of the invention are substituted cytosines of formula (I) wherein R1 is an aromatic or... Agent: Ecole Polytechnique Federale De Lausanne
20110207160 - Method for measuring low density lipoprotein cholesterol: It is an object of the present invention to provide a method capable of measuring low density lipoprotein cholesterol (LDL) in a body fluid with high selectivity. The present invention provides a method for measuring low density lipoprotein cholesterol (LDL-C) in a body fluid, which comprises treating the body fluid... Agent:
20110207158 - Method for the non-invasive detection of microorganisms in a closed container: The present invention relates to a method for detecting a contamination with a microorganism in a closed container, in which an extracellular enzyme of the microorganism is detected. The method can very suitably be carried out by providing a substrate for this enzyme to the contents of the container and... Agent: Nederlandse Organisatie Voor Toegepast-natuurwetenschappelijk Onderzoek Tno
20110207159 - Screening method for efficiently obtaining useful microbial strains from microbial sample obtained from natural environment and reagent and screening kit to be used therefor: A screening method for efficiently obtaining useful microbial strains from a sample comprises a first step of inoculating a culture medium with the sample potentially containing multiple microbial cells to culture the sample in the presence of a cell enlarger; a second step of introducing an esterase substrate fluorescent stain... Agent:
20110207161 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble CD44... Agent: Astute Medical, Inc.
20110207162 - Dynamic visualization of expressed gene networks in living cells: The present invention provides functional annotation of novel genes by detection of interactions of their encoded proteins with known proteins followed by assays to validate that the gene participates in a specific cellular function. The instant invention also provides an experimental strategy that allows for detection of protein interactions and... Agent: Odyssey Thera, Inc.
20110207163 - Method for and material of a shape standard: A method is disclosed for the preparation of isomorphic and nonspherical shape standards as isometric as possible and their mixtures for validation of the measurement methods and analyzers for quantification of particle shapes and their characteristics especially in the microscale and nanoscale size range. Furthermore the shape standards also provide... Agent: Dr. Lerche Kg
20110207164 - Method for assessment of folate phenotypes, disease risk and response to therapy: The invention provides a method for measuring the levels of 5-methyltetrahydrofolate (5-MTHF), tetrahydrofolate (THF), and 5,10-MTHF in a biological sample. The method includes employing an isotope dilution liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS) methodology.... Agent: The Trustees Of The University Of Pennsylvania
20110207165 - Small scale shaker flask cultivation: The present invention relates to a method for the cultivation of a mammalian cell in a cultivation medium of a cultivation vessel comprising adjusting the rate of a rotational movement of the cultivation vessel depending on the viable cell density in the cultivation medium.... Agent: Hoffman-la Roche, Inc.
20110207166 - Human bone marrow microenvironments and uses thereof: The present invention is directed to an in vitro cultured permissive niche, or human bone marrow microenvironment, comprising a scaffold coated with human mesenchymal stem cells and a culture medium, wherein the stem cells are viable and proliferate in culture and the niche is permissive for the establishment of introduced... Agent:
20110207168 - Fiber-based biosensors for use in detecting the presence of a biologically active substance: Disclosed are fibers comprising one or more electrostatically attached substrates that can be used to determine the presence of a biologically active substance. Further disclosed are substrates comprising the fibers, articles of manufacture comprising the fibers and/or substrates, and methods for detecting the presence of a biologically active substance.... Agent:
20110207167 - Method of isolating a cell from urine: A method of isolating a cell from a urine sample includes dialyzing the urine sample with a dialysate. The dialysate is separated from the urine sample by a dialysis membrane. The dialysis membrane excludes the passage of the cell through the dialysis membrane.... Agent:
20110207169 - System and method for anatomical pathology sample handling, storage, and analysis: A carrier strip having a plurality of areas for retaining anatomical pathology specimens may have a backing, a cover coupled to the backing along side regions located along opposite longitudinal edges of the carrier strip and along lateral intermediate regions positioned between each of the plurality of areas for retaining... Agent: Prairie Ventures, L.L.C.
20110207170 - Bioreactor exhaust: An exhaust system suitable for high volume exhaust from flexible disposable bags is described that prevents nutrient media volume loss and prevents cross-contamination without using any filters. The invention described here allows the use of disposable two-dimensional bioreactors for the cultivation of bacterial and other organisms and cells require high... Agent: Therapeutic Proteins Inc
20110207171 - Oligosaccharide modification and labeling of proteins: The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention.... Agent: Life Technologies Corporation
20110207172 - Process for the preparation of testosterone: The present invention relates to an industrial process for the reduction of 4-androstene-3,17-dione in order to obtain testosterone using a particularly stable and selective enzyme produced in a recombinant manner.... Agent:
20110207173 - Self-replicating vector lacking an antibiotic-resistance gene: The subject matter of the present invention is a novel vector and the use thereof for producing a heterologous protein or a gene of interest, that can be used, for example, in the context of an immunization or gene therapy programme and concerns in particular a self-replicating vector lacking an... Agent: Sanofi Pasteur S.a.
20110207174 - Peptide-containing culture medium for culturing animal cell: Disclosed is a culture medium for culturing an animal cell, which is characterized by containing a peptide comprising, as a constituent unit, an amino acid residue selected from the amino acid group consisting of serine, tyrosine and cysteine. The culture medium is suitable for the high level production of a... Agent: Chugai Seiyaku Kabushiki Kaisha
20110207175 - Multi-culture bioreactor system: There is provided co-culture bioreactor systems that can maintain stem cells and differentiated cell types in physically isolated environments but can allow biochemical communication between these cells. For instance, a co-culture bioreactor system of the present invention can include a first culture chamber that defines a first inlet and a... Agent: Mc2 Cell Aps
20110207176 - Method and apparatus for producing alcohol or sugar using a commercial-scale bioreactor: Provided is a method of producing alcohol or sugar in a commercial-scale bioreactor using a reformulated commercial enzyme preparation. Also provided is a bioreactor modified to practice the method.... Agent: Scientek LLC
20110207177 - Sugar production process and ethanol production process: The present invention provides a pretreatment method which enables the promotion of the enzymatic glycosylation of lignocellulose under relatively mild conditions by using a tree bark as a raw material with less energy. Specifically the present invention provides a step for producing a sugar from a tree bark, which is... Agent: Oji Paper Co., Ltd.
20110207178 - Method for producing hyaluronic acid: It is intended to provide a simple method for producing hyaluronic acid at a high yield. Further, it is also intended to provide a method for producing hyaluronic acid in a short period of time. The invention provides a method for producing hyaluronic acid including a step of culturing a... Agent:
20110207179 - Process for producing cmp-n-acetylneuraminic acid: The present invention is also directed to a process for producing CMP-N-acetylneuraminic acid (CMP-NeuAc), characterized in that the process includes adding yeast cells, N-acetylglucosamine-6-phosphate 2-epimerase (GlcNAc-6P 2-epimerase), N-acetylneuraminic acid synthase (NeuAc synthase), and CMP-N-acetylneuraminic acid synthase (CMP-NeuAc synthase) to a reaction system containing N-acetylglucosamine (GlcNAc) and cytidine 5′-monophosphate (CMP), and... Agent:
20110207180 - Temperature control device with a flexible temperature control surface: A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to... Agent:
20110207181 - Isomaltulose synthases, polynucleotides encoding them and uses therefor: The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose isomerases, methods for isolating such polynucleotides and nucleic acid constructs that express these polynucleotides. Also disclosed are cells, including transformed bacterial or plant cells, and... Agent: The University Of Queensland, St. Lucia
20110207182 - Novel thermophilic cellobiohydrolase: The present invention provides for a composition comprising a polypeptide comprising a first amino acid sequence having at least 70% identity with the amino acid sequence of Csac GH5 wherein said first amino acid sequence has a thermostable or thermophilic cellobiohydrolase (CBH) or exoglucanase activity.... Agent: Sandia Corporation
20110207183 - Production process for fine chemicals using microorganisms with reduced isocitrate dehydrogenase activity: The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially... Agent: Basf Se
20110207184 - Microorganism producing l-methionine precursor and the method of producing l-methionine precursor using the microorganism: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.... Agent: Cj Cheiljedang Corporation
20110207185 - Microorganisms and methods for the biosynthesis of p-toluate and terephthalate: The invention provides non-naturally occurring microbial organisms having a (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate pathway, p-toluate pathway, and/or terephthalate pathway. The invention additionally provides methods of using such organisms to produce (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate pathway, p-toluate pathway or terephthalate pathway.... Agent:
20110207186 - Isoforms of pig liver esterase: The invention relates to novel mutants of γPLE, to vehicles containing the same and to their use in the production of enantiomer-enriched alcohols, carboxylic acids and esters.... Agent: Enzymicals Ag
20110207187 - Bacterium producing 2-deoxy-scyllo-inosose (doi) and method of producing 2-deoxy-scyllo-inosose (doi) by using same: Disclosed is an Escherichia coli producing 2-deoxy-scyllo-inosose (DOI), which, from a sucrose non-PTS gene group, has at least a sucrose hydrolase (CscA)-encoding gene and which is provided with a DOI production system or has an enhanced DOI production system. The Escherichia coli preferably further includes a system to enhance sugar... Agent: Mitsui Chemicals, Inc.
20110207188 - Scyllo-inositol-producing cell and scyllo-inositol production method using said cells: An object of the present invention is to provide a cell capable of efficiently producing scyllo-inositol from myo-inositol and a simple method of manufacturing scyllo-inositol using the cell. The above-mentioned object is achieved by a Bacillus subtilis cell, in which a function of a protein having a scyllo-inositol dehydrogenase activity... Agent: National University Corporation Kobe University
20110207189 - Methods for increasing product yields: A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing... Agent:
20110207190 - Methods of xylitol preparation: The invention provides spray-dried preparations of microbes useful for oxidoreductase reactions, e.g., xylitol production, and methods of making and using those microbes.... Agent: University Of Iowa Research Foundation
20110207191 - Method for producing alcohol using bioethanol waste fermented solution: Provided is a method for producing alcohol or hydrogen gas comprising culturing alcohol-producing microorganisms in a waste fermented solution generated from the bioethanol production process. Glycerol included in the waste fermented solution generated from the bioethanol production process is converted by the microorganisms to butanol under an anaerobic condition. Since... Agent: Korea Institute Of Science And Technology
20110207192 - Method for the production of a fermentation product from a sugar hydrolysate: The present invention relates to a method for producing a fermentation product from a sugar hydrolysate. The method comprises fermenting the sugar hydrolysate in a fermentation system with yeast to produce a fermentation broth comprising a fermentation product; introducing acid and an oxidant, such as chlorine dioxide, to the fermentation... Agent: Iogen Energy Corporation
20110207193 - Novel microorganisms, selenium acid compound-reducing agent, method for reducing and method for removing selenium acid compound, and process for producing metallic selenium: Disclosed are novel microorganisms having an excellent ability to reduce selenium acid compounds, a selenium acid compound-reducing agent comprising such microorganism(s) as an active ingredient, a method for reducing and a method for removing a selenium acid compound with use of such microorganism(s), and a process for producing metallic selenium.... Agent:
20110207194 - Clostridium sartagoformum for the generation of biogas: A process is described for the generation of biogas from biomass in a fermentation reactor, wherein a microorganism of the species Clostridium sartagoformum is added to the biomass.... Agent:
20110207195 - Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two... Agent: Promega Corporation
20110207196 - Depth filter layer with inorganic layer double hydroxide: The present invention relates to a depth filter layer with inorganic layer double hydroxide, a method for production thereof, a filtration device containing this, a method for the separation of at least one contaminant from at least one target product in a liquid medium by means of at least one... Agent: Sartorius Stedim Iotech Gmbh
20110207198 - Compositions and methods for inhibiting mmset: The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic acids) that affect MMSET expression or activity.... Agent: The Regents Of The University Of Michigan
20110207197 - Method to inhibit ribonuclease dicer, ribonuclease dicer inhibitor, and use of rna aptamers as ribonuclease dicer inhibitors: The subject of the present invention is a method to inhibit ribonuclease Dicer, ribonuclease Dicer inhibitor, and use of RNA aptamers to inhibit ribonuclease Dicer. More specifically, this solution relates to using RNA aptamers as ribonuclease Dicer inhibitors that acts upon the competition basis (aptamers as competence inhibitors), use of... Agent: Instytut Chemii Bioorganicznej Pan
20110207199 - Novel method to generate meganucleases with altered characteristics: Method to generate and select a meganuclease having at least two altered characteristics in comparison to a parent meganuclease, comprising the steps: a. constructing from a parent meganuclease, a first series of variants which differ from said parent meganuclease by at least one acid amino substitution; b. screening the variants... Agent: Cellectis
20110207200 - Pseudomonas sp. strain and method of producing chitinase, chitosanase and nattokinase using the same: A Pseudomonas sp. strain TKU015 is deposited under DSMZ GmbH (Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH) Number DSM 21747). The Pseudomonas sp. strain TKU015 can be used to produce chitinase, chitosanase and nattokinase. A method of producing chitinase, chitosanase and nattokinases can use the Pseudomonas sp. strain TKU015.... Agent:
20110207201 - Alpha-amylase mutants: The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+... Agent: Novozymes A/s
20110207202 - Method for the production of adenoviral vectors: The invention provides methods for large-scale production of recombinant adenovirus 35, using perfusion systems and infection at very high-cell densities.... Agent: Crucell Holland Bv
20110207203 - Methods and compositions for the recombinant biosynthesis of n-alkanes: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.... Agent: Joule Unlimited, Inc.
20110207204 - Method and apparatus for bioremediation of soils and sediments: Biological plugs/conduits produce and distribute in situ a selected consortium of microorganisms appropriate to the treatment of a variety of soil and sediment contaminants. The bioplugs provide oxygen, air and/or other gases, nutrients, and a porous immobilization surface on which selected organisms are permitted to grow. Liquid such as water... Agent:
20110207205 - Chip for inspecting toxicity and efficacy: Disclosed herein is a chip for inspecting toxicity and efficacy, including: a first substrate including fitting holes formed at corners thereof; and a second substrate including gap forming members formed at corners thereof corresponding to the fitting holes to form a gap between the first substrate and the second substrate,... Agent:
20110207206 - Non-shrinkable sol-gel-polymer hybrid and methods thereof: A composite including a cross-linked interpenetrating network of an organic polymer including an alcohol adduct of, for example, a glycidyl ether substituted acrylate or epoxy substituted acrylate; and a sol-gel polymer. The composite having a low or no-shrinkage characteristic, and a method for making and using the composite, as defined... Agent:
20110207207 - Microfluidic cell sorter utilizing broadband coherent anti-stokes raman scattering: A microfluidic cell sorter has a microfluidic structure (500) with a sample input channel (1 1 0) leading into an observation region (214), two buffer channels (1 1 8) configured to hydrodynamically focus a sample target cell (208) within the observation region, and at least two output channels (1 1... Agent:
20110207208 - Compostation apparatus: A compostation apparatus comprising a construction enclosing piles of waste delivered by a conveyor, and a stirring device having vertical blades on a horizontal cable arranged to pass through the waste and aerate and vibrate it. The cable is spun between an electromagnet and a spring, and the electromagnet is... Agent:
20110207209 - Culture systems, apparatus, and related methods and articles: Culture systems, devices and related methods and articles may automate the culturing or incubation process according to defined culturing protocols. Such may employ removable multi-well growth cassette. Wells may be subdivided into subwells. Such may employ removable media and waste cartridges and/or gas canisters to supply consumables, which may be... Agent:
20110207210 - Isolated or synthesized rhopalosiphum padi virus polynucleotides having a promotor activity: Provided herein are isolated or synthesized Rhopalosiphum padi virus (RhPV) nucleic acids having promotor activities, and vectors containing the isolated or synthesized RhPV nucleic acids for gene delivery in insect expression systems.... Agent: Chung Yuan Christian University
20110207213 - Photoreactive synthetic regulator of protein function and methods of use thereof: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.... Agent:
20110207212 - T1r taste receptors and genes encoding same: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent:
20110207214 - Novel tools for the production of glycosylated proteins in host cells: The invention improves glycoprotein production and protein glycosylation engineering in eukaryotes, specifically the production of human-like complex or hybrid glycosylated proteins in lower eukaryotes such as yeasts. The invention provides glycosylation modified eukaryotic host cells capable of producing glycosylation optimized proteins useful as immunoglobulins and other therapeutic proteins, and provides... Agent: Lonza Ltd
20110207215 - Cell storage method and cell transport method: To provide a cell storage method to store living cells while maintaining the functions of the living cells. An aspect of the cell storage method is a method to store living cells (40) by using a cell culture chamber (20) including a plurality of the microchambers (11), the method including:... Agent: Public University Corp. Yokohama City University
20110207216 - Synthetic peptide (meth) acrylate microcarriers: A process for forming microcarriers includes contacting an initiator-conjugated microcarrier base with one or more monomers and activating the initiator to initiate polymerization and to graft a polymer from the base via the initiator or a remnant thereof. At least one of the monomers is conjugated to a polypeptide so... Agent:
20110207217 - Modulation of gene expression by oligomers targeted to chromosomal dna: Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.... Agent: Board Of Regents, The University Of Texas System
20110207218 - Mixing system with condenser: A system for mixing a liquid solution or suspension includes a support housing bounding a compartment and a collapsible bag disposed within the compartment. A mixer is disposed within the collapsible bag while a sparger delivers a gas to the lower end of the collapsible bag. A gas outlet line... Agent: Hyclone Laboratories, Inc.
20110207220 - Cell pattern recovery tool: This invention provides a cell pattern recovery tool comprising a base material layer having a surface subjected to easy adhesion treatment, a temperature responsive polymer layer that is provided on the base material layer and has a surface subjected to silane treatment, and a cell adhesion inhibiting material layer provided... Agent: Dai Nippon Printing Co., Ltd.
20110207219 - Modified substrates for protection of peptide-immobilized surfaces from gamma radiation degradation: In the present specification and claims, three modified cell culture substrates are disclosed for protecting peptide mimetic surfaces used in cell culture technology. The methods are able to retain the functionality of the bioactive species conjugated to the surface. In particular, a vitronectin peptide fragment Ac-Lys-Gly-Gly-Pro-Gln-Val-Thr-Arg-Gly-Asp-Val-Phe-Thr-Met-Pro-NH2 was able to facilitate... Agent:
20110207222 - Methods and systems for manipulating particles using a fluidized bed: The present invention comprises methods and systems for manipulation of media and particles, whether inert materials or biomaterials, such as cells in suspension cell culture. The methods and systems comprise use of an apparatus comprising a rotating chamber wherein the actions of the combined forces of gravity, fluid flow force... Agent:
20110207221 - Targeted genomic modification with partially single-stranded donor molecules: Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.... Agent: Sangamo Biosciences, Inc.
20110207224 - In vivo production of small interfering rnas that mediate gene silencing: The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered... Agent: University Of Massachusetts
20110207225 - Methods and systems for manipulating particles using a fluidized bed: The present invention comprises methods and systems for manipulation of media and particles, whether inert materials or biomaterials, such as cells in suspension cell culture. The methods and systems comprise use of an apparatus comprising a rotating chamber wherein the actions of the combined forces fluid flow force and centrifugal... Agent:
20110207223 - Methods of generating alphavirus particles: Strategies for increasing the productivity of alphavirus packaging cell lines and of reducing the possibility that replication competent virus may be generated during large scale production of recombinant alphavirus particles.... Agent:
20110207226 - Non-integrating lenti/adeno-associated virus hybrid vector system: The present invention provides for a hybrid vector system for the purpose of therapeutic gene delivery where the system is used for a targeted integration of a therapeutic gene into a genome. The hybrid vector system comprises a hybrid vector made up of a non-integrating lentiviral vector and an adeno-associated... Agent: Virxsys Corporation08/18/2011 > 140 patent applications in 76 patent subcategories. inventions list
20110200981 - Polymerized hemoglobin media and its use in isolation and transplantation of islet cells: Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are also disclosed. The solutions and suspensions may be employed in methods of... Agent: Opk Biotech LLC
20110200986 - Bio-assay using liquid crystals: There is provided a method, an in vitro method and a detection system for detecting the presence of at least one biological molecule in at least one sample. The method can include, for example, providing a sample and/or a binding agent to a contact portion of a surface by way... Agent: National University Of Singapore
20110200985 - Compositions for use in identification of herpesviruses: The present invention relates generally to identification of herpesviruses and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent:
20110200982 - Genetically modified mice and engraftment: A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic... Agent: Yale University
20110200983 - Methods and materials for detecting viral or microbial infections: This document provides methods and materials for detecting target nucleic acid. For example, methods and materials for detecting the presence or absence of target nucleic acid, methods and materials for detecting the amount of target nucleic acid present within a sample, kits for detecting the presence or absence of target... Agent:
20110200984 - Using nucleic acids for clinical microbiology testing: A process for analysing a biological sample, comprising the steps of: (a) identifying a micro-organism present within the sample; and (b) determining the effect of one or more antimicrobial(s) on a micro-organism from the sample, wherein steps (a) and (b) are performed by analysing the micro-organism's nucleic acid. Steps (a)... Agent: 3m Innovative Properties Company
20110200988 - 3'-oh unblocked uncleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in dna squencing: Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the nucleobase to include a fluorescent dye attached via a linker... Agent:
20110200991 - Automated system for isolating, amplifying and detecting a target nucleic acid sequence: A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively compliant articulated robot arm (SCARA). This synergistic integration of previously separate diagnostic tools creates a system and method whereby a minimum of... Agent:
20110200992 - Biological compositions, articles and methods for monitoring sterilization processes: A sterility indicating composition comprising a plurality of sterilization process resistant spores; a germination medium comprising a sub-lethal amount of at least one cell-permeant nucleic acid-interacting fluorescent dye and at least one nutrient for germination of the spores; wherein the at least one cell-permeant fluorescent dye can interact with nucleic... Agent:
20110200987 - Compositions and methods for modifying cellular properties: The invention generally provides compositions and methods for modulating cell properties and enhancing recombinant protein yields. In particular, the compositions and methods provide for cells having altered growth characteristics, including altered adhesion, rate of proliferation, growth to particular cell density, and recombinant protein expression level.... Agent: The John Hopkins University
20110200990 - Receptor activator of nf kappa-b: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.... Agent: Immunex Corporation
20110200989 - Single molecule nucleic acid sequencing using multiphoton fluorescence excitation: A system for detection of nucleic acids can include an excitation source configured to transmit excitation energy to a reaction site including a single molecule of nucleic acid reacted with a two-photon absorption moiety. The system also can include an optical system configured to focus the excitation energy transmitted from... Agent:
20110201002 - 2'-terminator nucleotide-related methods and systems: The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2′-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention also provides computers and computer readable media.... Agent: Roche Molecular Systems, Inc.
20110200996 - Compositions and methods for detection of colorectal cancer: We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with... Agent:
20110200997 - Compositions for use in identification of enteric bacterial pathogens: The present invention relates generally to identification of enteric bacterial pathogens, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent: Ibis Biosciences, Inc.
20110201007 - Diagnostic test for streptococcus equi: The invention relates generally to methods and materials concerning diseases caused by Streptococcus equi, and in particular relating to the detection of this pathogen by assessing the presence or absence of the S. equi eqbE gene sequence.... Agent: Animal Health Trust
20110201004 - Digital amplification: The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules... Agent: The Johns Hopkins University
20110200994 - Method for diagnosing a genetic predisposition for vascular disease: The invention relates to a method for diagnosing a genetic predisposition for a vascular disease, in particular for a coronary artery disease (CAD). According to the invention, the method has the following steps: Providing a sample containing a nucleic acid derived from the gene GCH1; and determining the presence or... Agent:
20110201003 - Method for obtaining purkinje progenitor cell by using neph3(65b13) and e-cadherin: 65B13 was discovered to be a useful marker for isolating GABA neuron progenitor cells including Purkinje cells. Furthermore, E-cadherin was revealed to be a useful marker for isolating Purkinje progenitor cells from a 65B13-positive cell population. Specifically, when used in combination with 65B13, E-cadherin was found to be a useful... Agent: Eisai R&d Management Co., Ltd.
20110201001 - Methods and materials for assessing rna expression: This document provides methods and materials for assessing RNA expression. For example, methods and materials for detecting the presence, absence, or amount of target nucleic acid (e.g., target RNA or target cDNA produced from target RNA), kits for detecting the presence, absence, or amount of target nucleic acid (e.g., target... Agent:
20110201000 - Methods and materials for detecting genetic or epigenetic elements: This document provides methods and materials for detecting genetic and/or epigenetic elements. For example, methods and materials for detecting the presence or absence of target nucleic acid containing a genetic or epigenetic element, methods and materials for detecting the amount of target nucleic acid containing a genetic or epigenetic element... Agent:
20110201005 - Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders: The invention provides methods, nucleic acids and kits for detecting metastasis of colon cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of metastasis of colon cell proliferative disorders, thereby enabling the improved diagnosis and treatment of patients.... Agent: Epigenomics Ag
20110200993 - New treatment of autoimmune conditions: The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In particular, the invention relates to methods and materials involved in identifying agent suitable for the prophylaxis, prevention and/or treatment of an autoimmune condition. The invention further relates to methods and materials involved in diagnosing autoimmune... Agent: Redoxis Aktiebolag
20110200999 - Novel device and method for rapid detection of microorganisms: The present invention is directed to a platform technology for quick and easy detection and identification of single or multiple microorganisms in a sample using peptide labeled oligonucleotides (PLONs). The PLONs are specifically designed to be complementary to certain nucleic acid sequences on a target microorganism. When the PLONs of... Agent:
20110201006 - Oligonucleotide detection method: The invention relates to a method for the detection of oligonucleotides using anion exchange high performance liquid chromatography. Fluorescently labelled peptide nucleic acid oligomers, complementary to the oligonucleotide are hybridized to the oligonucleotides. Anion exchange high performance liquid chromatography is then performed and the hybridized moieties detected and quantitated. The... Agent:
20110200995 - Optimized probes and primers and methods of using same for the detection, screening, isolation and sequencing of vancomycin resistance genes and vancomycin resistant enterococci: Described herein are primers and probes useful for detecting, screening, isolating, and sequencing of the vancomycin resistance genes and vancomycin resistant Enterococci and methods of using the described primers and probes.... Agent: Intelligent Medical Devices, Inc.
20110200998 - Prognosis and therapy predictive markers and methods of use: Disclosed is a set of genes differentially expressed in chemotherapy and radiation resistant tumors useful in predicting response to therapy and assessing risk of local-regional failure, survival and metastasis in cancer patients. Also disclosed are methods for characterizing tumors according to gene expression and kits for use in the methods... Agent: The University Of Chicago
20110201008 - Assays, methods and kits for measuring response to therapy and predicting clinical outcome in patients with b-cell lymphoma: Assays, methods and kits for predicting survival outcome in a subject having diffuse large B-cell lymphoma (DLBCL) and for measuring a subject's response to DLBCL therapy involve specific miRNAs that are prognostic biomarkers for prediction of outcome of DLBCL patients. Expression of miRNAs miR-18a, miR-181a and miR-222 is associated with... Agent: University Of Miami
20110201010 - Compositions and methods for the protection of nucleophilic groups: The present invention provides compositions, methods, and kits relating to the protection and deprotection of molecules comprising nucleophilic groups, such as the protection and deprotection of thermostable polymerases. Also provided are methods of performing nucleic acid amplification using polymerases protected according to the invention.... Agent:
20110201009 - Microfabricated crossflow devices and methods: A microfluidic device for analyzing and/or sorting biological materials (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for its use are provided. The device and methods of the invention are useful for sorting particles, e.g. virions. The invention is also useful for... Agent: California Institute Of Technology
20110201011 - Methods for assaying mc1r variants and mitochondrial markers in skin samples: The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying,... Agent: Mitomics Inc.
20110201012 - Methods and compositions for diagnosing epithelial cell cancer: Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP... Agent:
20110201014 - Antibody binding to envelope protein 2 of hepatitis c virus and method for identifying genotype of hepatitis c virus using the same: The present invention provides an antibody that specifically binds to envelope protein 2 of HCV of genotype 2a but does not immunologically react with envelope protein 2 of HCV of genotype 1a.... Agent:
20110201013 - Assays and devices for identifying pathogens: Provided are methods and devices for identifying pathogens based on protein translation from ribosomes isolated from the pathogens.... Agent:
20110201017 - Lupus anticoagulent testing: The present invention relates generally to the field of diagnostic screening and diagnostic assays. In particular, the present invention provides an improved, rapid, and efficient method of screening for antiphospholipid antibodies, such as lupus anticoagulants (LA). The invention also relates to a kit for screening plasma levels for antiphospholipid antibodies... Agent: American Diagnostica, Inc.
20110201016 - Method for detecting modulator for regulating activity of cellular component in cell: A method for detecting a modulator that can regulate biological and/or physiological activity of a cellular component is provided. The method can detect a modulator, after determining whether there is a competitive reaction between a reference substance and a modulator toward the cellular component in a cell by imaging a... Agent: Mediscov Inc.
20110201015 - Method for measuring endotoxin and reagent kit for measuring endotoxin: A technique which is less likely to be affected by turbid or color of samples and with which prompt and simple detection or concentration measurement of endotoxin can be achieved is provided. A reagent in which proteins contained in LAL are adsorbed or bound onto fine particles dispersed in a... Agent:
20110201019 - Methods and compositions for detecting receptor-ligand interactions in single cells: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The... Agent:
20110201018 - Methods and compositions for risk stratification: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in... Agent:
20110201027 - Biosensor for detecting a trace amount of sample and production method therefor: The present invention relates to a biosensor capable of a trace amount of sample and a fabrication method thereof. More specifically, the invention relates to a method for fabricating a biosensor, the method comprising: immobilizing a receptor molecule, which binds selectively to a target substance, on an electrically insulated nano-electrode... Agent: Korea Research Institute Of Bioscience And Biotechnology
20110201030 - Human g-protein chemokine receptor (ccr5) hdgnr10: Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat... Agent: Human Genome Sciences, Inc.
20110201029 - Il-13 receptor antibodies: This invention relates to monoclonal and polyclonal antibodies capable of specifically recognizing IL-13 receptor α and uses thereof.... Agent: Sanofi-aventis
20110201031 - Preparation method: A method of performing an immunologic evaluation of a subject, comprising collecting a whole blood sample from the subject, maintaining the sample for at least 6 hours after collection, purifying a population of cells comprising lymphocytes and antigen presenting cells from the maintained sample, optionally by a process incorporating a... Agent: Oxford Immunotec Limited
20110201032 - Immunosensors: scfv-linker design for surface immobilization: An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule... Agent: Vanderbilt University
20110201022 - Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase: Provided herein are methods of detecting the presence of a pegylated enzyme, an enzyme-specific antibody (e.g., a neutralizing antibody or of a particular isotype), or a polyethylene glycol (PEG)-specific antibody in a sample, such as a bodily fluid or tissue of a patient. In certain embodiments, the enzyme is phenylalanine... Agent: Biomarin Pharmaceutical Inc.
20110201023 - Mannose 6-phosphate-binding antibodies and their uses: The present invention relates to an isolated antibody or antigen-binding fragment thereof which specifically binds to mannose 6-phosphate and methods for preparing such antibody or antigen-binding fragment thereof. The invention further relates to a nucleic acid molecule encoding such antibody or antibody fragment, an expression vector comprising such nucleic acid... Agent: Forschungszentrum Borstel
20110201021 - Use of the irap protein for implementing methods of diagnosis and of prognosis: The use of the IRAP protein for implementing methods of diagnosis and of prognosis.... Agent: Universite Joseph Fourier
20110201024 - Compositions comprising a dehalogenase substrate and a fluorescent label and methods of use: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one... Agent: Promega Corporation
20110201025 - Polymer-coupled peptidases: The present invention is directed to a simple process for the modification of the specificity of a peptidase of the hemostatic system by coupling polymers to the peptidase causing it to lose its reactivity in the hemostatic system, but enabling it to continue to react with certain inhibitors, effectors and... Agent: Jenaffin Gmbh
20110201026 - Compositions and methods for the detection of antibodies to native human leukocyte antigen: Provided herein are compositions comprising native and denatured human leukocyte antigens (HLA) and methods of making said compositions. Also provided herein are methods and kits for the detection of antibodies to native HLAs.... Agent: One Lambda, Inc.
20110201035 - Compositions and methods for the detection of hiv-1/hiv-2 infection: This invention relates to compositions and methods or the detection of immunodeficiency virs infection, especially immunodeficiency virus-1 (HIV-1) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-HIV-1 antibodies.... Agent: The United States Of America As Represented By The Secretary Of Health And Human Services, Nih
20110201036 - Endometriosis markers: The present invention relates to methods for determining a risk or identifying a condition associated with the presence of endometriosis in a subject as well as testing a candidate compound for a therapeutic activity for the treatment of endometriosis and sorting patients based on the risk of having endometriosis. Specifically,... Agent:
20110201033 - G immunoglobulin used against anthrax toxins: e
20110201034 - Method and kit for detecting antibody to avibacterium paragallinarum: A method and a kit for detecting an antibody to Avibacterium paragallinarum are provided. A method for detecting an antibody to Avibacterium paragallinarum which comprises detecting an antibody induced by an outer-membrane protein of Avibacterium paragallinarum serotype A and/or serotype C by ELISA with a solid phase to which a... Agent: The Chemo-sero-therapeutic Res Inst
20110201038 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Cytoplasmic aspartate... Agent: Astute Medical, Inc.
20110201037 - Use of erythropoietin to develop small molecule inhibitors of janus kinase-2: The invention pertains to a method for identifying compounds that inhibit the erythropoietin-induced JAK2 kinase activity in vivo. The present invention provides a method for detecting small molecule JAK2 inhibitors in a rapidly created rodent model that phenocopies human PV through Epo stimulation. The method comprises the steps of (a)... Agent:
20110201039 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: A process of quantifying proteins in a complex mixture is provided. The invention has utility in quantifying proteins in a complex preparation of uni- or multivalent commercial or research vaccine preparations.... Agent: The Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services
20110201047 - novel sorting technology that allows for highly efficient selection of sperm without chromatin damage: This invention provides a method to select and enrich healthy sperm for use in assisted reproductive techniques comprising incubating sperm with at least one marking reagent that enters unhealthy sperm but not healthy sperm. The invention also provides a method to sort healthy sperm of high viability from apoptotic, necrotic... Agent: Cornell University
20110201041 - Encapsulation of nano-materials for fluid purification/separation: Disclosed is an apparatus and method whereby small particle nano materials may be contained in a highly functional package for fluid separation and/or purification applications. The package consists of an aerogel material which uniformly surrounds the nano-particles. The aerogel may be composed of carbon, silicon, or silicon oxide or other... Agent:
20110201042 - Inhibitors of bacterial nitric oxide synthase, and related screening methods: The invention relates in part to compounds that act as highly nitric oxide (NO)-specific turn-on fluorescent probes. The present invention also relates to the use of these fluorescein-based sensors to screen selectively for inhibitors of bacterial nitric oxide synthase (bNOS). Compounds of the present invention readily detect nitric oxide produced... Agent: Massachusetts Institute Of Technology
20110201045 - Method and apparatus for performing hematologic analysis using an array-imaging system for imaging and analysis of a centrifuged analysis tube: A method and device for analyzing a hematologic sample centrifuged within a capillary tube is provided. The device includes a tube holder, a sample imaging device, a processor, and a sample data display. The sample imaging device is operable to create a digital image of the sample within a region... Agent:
20110201040 - Non-mccj25-related lariat-peptide inhibitors of bacterial rna polymerase: The invention provides a method of inhibiting a bacterial RNA polymerases. The invention has applications in control of bacterial RNA polymerase activity, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.... Agent: Rutgers, The State University Of New Jersey
20110201048 - Screening method of therapeutic and diagnostic agents for tnf-alpha-induced diseases using reactive oxygen species modulator 1: Disclosed are methods for screening therapeutics, prophylactics or pain alleviators for diseases induced by TNF-α, a main mediator of inflammation and in ROS production and cell death, and for diagnosing the diseases, and a diagnostic kit. For this, a nucleotide sequence and an amino acid sequence of Romo1, which plays... Agent: Korea University Research And Business Foundation
20110201046 - T1r hetero-oligomeric taste receptors: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors arc described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are... Agent: Senomyx, Inc.
20110201043 - Transgenic mammals and cell lines for the identification of glutamate transporter modulators: The invention includes a transgenic, non-human mammal useful for identifying candidate compounds for treating neurological and/or psychiatric disorders. Incorporated into the genome of the transgenic mammal is a transgene comprising a glutamate transporter promoter operatively linked to a reporter gene. The transgenic, non-human mammal and cells isolated therefrom can be... Agent: The Johns Hopkins University
20110201044 - Tuberculosis diagnostic test: A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which... Agent: Isis Innovation Limited
20110201049 - Compositions for the detection of microbial contaminants: The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial... Agent: Charles River Laboratories, Inc.
20110201050 - Gas scrubbed perfusion filter: Fine gas bubbles traveling at fast speed are employed to scrub a hard-surface filter for harvesting liquids from suspensions including those consisting of nutrient media and cell culture, on a continuous basis without clogging the filters.... Agent: Therapeutic Proteins Inc.
20110201051 - Chemosensory gene family encoding gustatory and olfactory receptors and uses thereof: This invention provides an isolated nucleic acid encoding an insect gustatory or odorant receptor. This invention provides a nucleic acid of at least 12 nucleotides capable of specifically hybridizing with a nucleic acid encoding an insect gustatory or odorant receptor. This invention also provides a purified, insect gustatory or odorant... Agent: The Trustees Of Columbia University In The City Of New York
20110201052 - Nucleic acids and corresponding proteins entitled 202p5a5 useful in treatment and detection of cancer: A novel gene 202P5A5 and its encoded protein, and variants thereof, are described wherein 202P5A5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 202P5A5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 202P5A5 gene or... Agent: Agensys, Inc.
20110201053 - Recombinant expression vector elements (reves) for enhancing expression of recombinant proteins in host cells: Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described.... Agent:
20110201054 - Process for improved recovery of fermentation products from intracellular and extracellular presence: The present invention increases yield of the target fermented molecules by spray drying the fermentation broth and reducing the process volume to nearly one tenth the original. Thus, none of the target molecules are lost and requirements of the solvent and the other conventional method process equipments and processing materials... Agent: Viridis Biopharma Pvt Ltd
20110201055 - Engineered cleavage half-domains: Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.... Agent:
20110201056 - Repair of nucleic acids for improved amplification: The reaction mixture may further contain an AP endonuclease and a polymerase. These enzymes are optionally selected according to their ability to withstand high temperatures so they can be included in an amplification mixture. The reaction mixture may be used prior to a polynucleotide synthesis reaction in which case enzymes... Agent: New England Biolabs, Inc.
20110201057 - Methods for high fidelity production of long nucleic acid molecules with error control: A method for synthesizing a nucleic acid having a desired sequence and length comprises providing a solid support having an immobilized nucleic acid, performing a nucleic acid addition reaction to elongate the immobilized nucleic acid by adding a nucleotide or an oligonucleotide to the nucleic acid, determining whether the nucleotide... Agent: Massachusetts Institute Of Technology
20110201058 - Whole transciptome sequencing: Methods for preparing strand-specific sequencing libraries of oligonucleotides using an RNA polymerase promoter to re-transcribe antisense cDNA which has been reverse transcribed from mRNA are provided. The transcription step linearly amplifies sRNA prior to production of double-stranded cDNA to be sequenced and may be sufficient to eliminate the conventional PCR... Agent: Genisphere, LLC
20110201059 - Compositions and methods for producing fermentable carbohydrates: Provided herein are methods for producing fermentable sugar obtained from a plant tissue. The methods include providing transgenic plant material comprising one or more locked carbohydrates and contacting plant material with an enzyme capable of converting the locked carbohydrate into a fermentable sugar. The methods are useful for providing sugar... Agent:
20110201060 - Process for the preparation of scyllo-inositol: This invention pertains to a process for manufacturing scyllo-Inositol. Specifically, the current invention pertains to a process for converting myo-Inositol to scyllo-Inositol using a bioconversion process.... Agent: Abbott Laboratories
20110201061 - Process for hydrolysis of wet fiber and method for producing fermentation products from wet fiber: Disclosed are a method of hydrolysis of wet fiber and a method for preparing ethanol. Generally, an agricultural plant material, such as corn hulls, distiller's dried grains, or spent germ, is treated to at least partially hydrolyze the fiber. The process may include a maceration step followed by a shearing... Agent:
20110201062 - Bacterium capable of producing l-amino acid and method for producing l-amino acid: A bacterium is described which belongs to the Enterobacteriaceae family, and has an ability to produce an L-amino acid, such as L-glutamic acid, L-arginine and L-threonine. The bacterium is modified so that the activity of a protein encoded by ydcl gene is decreased, thereby producing and accumulating the L-amino acid... Agent:
20110201063 - Algae growth for biofuels: A method and apparatus of algal oil production including the steps of: control growing to provide intensive growth to supply starting means for algae farming; Farming algae from using primarily sunlight Processing algae from the farmed algae preferably using a wet extraction process: and wherein at least one of the... Agent:
20110201064 - Conversion to bioenergy from biomass of protistan grazers feeding on aquatic plant and/or algae which can survive and uptake greenhouse gases in the mixture of toxic gases and substance: Provided are a method for removing and/or absorbing greenhouse gases using aquatic plant and/or algae having a greenhouse gas absorbing performance and resistance to toxic substances, a method for producing bioenergy using predators with high fatty acids, and a method for producing bioenergy including cultivating aquatic plant and/or algae having... Agent: Snu R&db Foundation
20110201066 - Production of fatty acid alkyl esters by use of two lipolytic enzymes: A method for producing fatty acid alkyl esters, wherein a solution comprising triglyceride and alcohol is contacted with a first lipolytic enzyme having a relatively higher activity on free fatty acids than on triglyceride and a second lipolytic enzyme having a relatively higher activity on triglyceride than on free fatty... Agent: Novozymes A/s
20110201065 - Synthesis of long-chain polyunsaturated fatty acids by recombinant cells: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group... Agent: Commonwealth Scientific And Industrial Research Organisation
20110201067 - Method for preparing polylactate and copolymer thereof using a mutant microorganism with enhanced polylactate, and the copolymer producing capability thereof: Provided is a method of preparing polylactate (PLA) or a copolymer thereof using a mutant microorganism in which a gene participating in a coenzyme A (CoA) donor- and lactate-producing pathway is genetically manipulated to increase the productivity of a CoA donor and lactate. Amounts of the CoA donor and the... Agent: Korea Advanced Institute Of Science And Technology
20110201068 - Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids: The invention provides a non-naturally occurring microbial organism having n-propanol and isopropanol pathways, 1,4-butanediol (14-BDO) and isopropanol pathways, 1,3-butanediol (13-BDO) and isopropanol pathways or methylacrylic acid (MAA) and isopropanolpathways. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in each of the respective n-propanol, 14-BDO, 13-BDO... Agent:
20110201069 - Method for producing oligomer and/or monomer by degrading biodegradable resin: The present invention provides a method for producing an oligomer and/or a monomer by degrading a biodegradable resin in a degradation liquid containing a biodegradation enzyme, a buffer agent, an organic solvent, and water. In this method, the SP value of the organic solvent is less than 8.5 or more... Agent: Toyo Seikan Kaisha Ltd.
20110201071 - Methods and organisms for the growth-coupled production of 1,4-butanediol: The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby theone or more gene... Agent: Genomatica, Inc.
20110201072 - Modified alcohol dehydrogenases for the production of fuels and chemicals: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and... Agent: Gevo, Inc.
20110201073 - Reduced by-product accumulation for improved production of isobutanol: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and... Agent: Gevo, Inc.
20110201074 - Thermophilic micro-organisms for ethanol production: A thermophilic micro-organism comprising a modification that increases amylase expression and starch hydrolysis compared to wild-type, wherein the modification is insertion of a heterologous amylase gene.... Agent: Tmo Renewables Limited
20110201075 - Optoinjection methods: Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse... Agent: Cyntellect, Inc.
20110201076 - Harvesting micro algae: A reusable composite paramagnetic particle may comprise a paramagnetic core encased by a protective material to which is grafted a tendril layer comprising a plurality of polymeric chains. The polymeric chains may be designed to interact with a microorganism. The interaction between the microorganism and the polymeric chain may be... Agent: Colorado School Of Mines
20110201077 - Composition, method, and kit for preparing plasmin: A streptokinase immobilized on a surface, in particular an immobilized plasmin-resistant streptokinase, and compositions, methods and kits of utilizing same for preparing plasmin are provided.... Agent: Talecris Biotherapeutics ,inc.
20110201079 - Identification and modification of dynamical regions in proteins for alteration of enzyme catalytic effect: A method for analysis, control, and manipulation for improvement of the chemical reaction rate of a protein-mediated reaction is provided. Enzymes, which typically comprise protein molecules, are very efficient catalysts that enhance chemical reaction rates by many orders of magnitude. Enzymes are widely used for a number of functions in... Agent: Ut-battelle, LLC
20110201078 - Ligand functionalized polymers: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.... Agent: 3m Innovative Properties Company
20110201081 - Buttiauxella sp. phytase variants: Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate digestion in foods and animal feeds.... Agent:
20110201082 - Polypeptides having endoglucanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes A/s
20110201083 - Production of c5-c8 alcohols using evolved enzymes and metabolically engineered microorganisms: Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing higher alcohols including C5-C8 alcohol from a suitable substrate.... Agent: The Regents Of The University Of California
20110201084 - Enzymatic hydrolysis of cellulosic biomass through enhanced removal of oligomers: The methods and composition of the disclosure are directed to the reducing cellulase inhibition by xylooligomers through adding hemicellulase enzymes that break xylooligomers down to monomeric sugars with a corresponding increase in glucose release. What was heretofore unknown is that xylobiose and higher xylooligomers inhibit enzymatic hydrolysis of any lignocellulosic... Agent: The Regents Of The University Of California
20110201085 - Nucleic acid extraction from complex matrices: The present disclosure describes an adsorbent and exemplary protocols for extracting nucleic acids, such as DNA and RNA, from complex matrices, such as stool samples and water samples. The adsorbent is activated charcoal coated with a material such as polyvinylpyrrolidone, dextran, or coconut flours. The adsorbent may be used in... Agent: Phthisis Diagnostics Corporation
20110201087 - Compositions and methods for the production of alpha-herpesviruses: The present invention relates to virus growth media that improve the yield of alpha-herpesviruses (e.g., HSV-2) grown in cell cultures. The growth media of the invention include two additives, a disaccharide and a lipid mixture, that can be added to serum-free or serum-enriched growth media to improve the efficiency of... Agent: Sanofi Pasteur Biologics Co.
20110201086 - Method for producing recombinant virus: To provide a method for producing, at high purity, a recombinant baculovirus which exhibits intended immunogenicity and is useful for a pharmaceutical (e.g., a vaccine), a transfer vector for use in the production of the recombinant baculovirus, and a method for producing the transfer vector. The method for producing a... Agent: Otsuka Pharmaceutical Co., Ltd.
20110201088 - Production of raav in vero cells using particular adenovirus helpers: The present invention relates to methods and materials for recombinant adeno-associated virus production. More particularly, in some embodiments the invention contemplates the use of an adenovirus known as Simian Adenovirus 13 (SAdV-13) and Vero cells for production of recombinant adeno-associated virus (rAAV).... Agent: Nationwide Children's Hospital Inc.
20110201089 - Methods for increasing product yields: A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing... Agent:
20110201090 - Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals, and amino acids: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and... Agent: Gevo, Inc.
20110201091 - Production of microbial growth stimulant with ammonia fiber explosion (afex) pretreatment and cellulose hydrolysis: A process for producing a microbial growth stimulant (MGS) from a plant biomass is described. An ammonium hydroxide solution is used to extract a solution of proteins and ammonia from the biomass. Some of the proteins and ammonia are separated from the extracted solution to provide the MGS solution. The... Agent: Board Of Trustees Of Michigan State University
20110201092 - Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the listeria, and methods of use thereof: The present invention provides Listeria that are attenuated for entry into non-phagocytic cells as well as a variety of methods of inducing immune responses involving administering compositions comprising the attenuated Listeria. Some of the attenuated Listeria are mutant Listeria that comprise at least one mutation in a gene encoding an... Agent:
20110201093 - Glucose conversion to ethanol via yeast cultures and bicarbonate ions: The present invention is directed to the enhanced production of ethanol from fermentation using an ethanol producing microorganism. In particular, the present invention provides a process for the enhanced growth and metabolism of an ethanol producing microorganism (e.g., yeast), for the purpose of increasing or enhancing ethanol production, both in... Agent: Church & Dwight Co., Inc.
20110201094 - Methods and compositions for growth of hydrocarbons in botryococcus sp.: Acceleration of botryococcenoids and growth by concomitant provision of appropriate light, minerals, and assimilable carbon. Specifically, methods, compositions and systems for the in vitro growth of hydrocarbons in photosynthetic organisms while maintaining a biologically exclusive monocultural environment, as for example, from Botryococcus species, is disclosed. Niche-nutrients can include about 200... Agent:
20110201095 - Method of treating a sulphide mineral: A copper bioleaching process which makes use of a consortium which contains Leptospirillum ferriphilum and a sulphur oxidising microorganism which is halophilic or halotolerant.... Agent:
20110201096 - Method for digesting a biomass comprising lignin together with cellulose and/or hemicellulose: The invention relates to a method for digesting a biomass comprising, lignin, cellulose, and hemicellulose, comprising the steps of: (a) contacting the biomass with a first solvent for dissolving the cellulose and/or the hemicellulose, (b) contacting the dissolved cellulose and/or hemicellulose with a precipitant for forming a precipitate comprising cellulose... Agent:
20110201097 - Ionic liquid apparatus and method for biological samples: Apparatus and method for handling biological samples. Segments of ionic liquid can provide voltage across segments of immiscible liquid to concentrate or separate charged species in the biological samples. Reactants in biological samples can be contacted and reacted in segments of immiscible liquid.... Agent: Life Technologies Corporation
20110201098 - Polymer replicated interdigitated electrode array for bio(sensing) applications: A sensor is disclosed. In one embodiment, the sensor includes an insulating substrate comprising a first zone, a second zone, and an intermediate zone, where the intermediate zone comprises a portion of the second zone that overlaps the first zone. The sensor further comprises a first electrode in the first... Agent: Innogenetics
20110201099 - Assay cartridges and methods of using the same: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample... Agent: Meso Scale Technologies, LLC.
20110201101 - Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same: Disclosed is a microfluidic structure and a microfluidic device comprising the microfluidic device, which is suitable for detecting a target material. The microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.... Agent: Samsung Electronics Co., Ltd.
20110201100 - Single use cell culture bioreactor manifold system: The invention provides a disposable cell culture bioreactor manifold system for use in coupling sensors, fluid samplers, conduits, and the like, to a cell culture bioreactor in a sterile manner. The disposable bioreactor manifold system includes an externally attachable bioreactor manifold connector body for fluidly attaching modular sensor arrangements that... Agent: Millipore Corporation
20110201102 - Method and apparatus for cultivating organisms: e
20110201103 - System for synergetic expression of multiple small functional rna elements: The present invention relates in general to microRNAs (miRNAs). More specifically, the invention relates to expression vectors comprising multiple miRNA families and clusters capable of targeting multiple oncogenic pathways.... Agent: University Of Southern California
20110201104 - Antiviral agent against animal viruses: Disclosed herein is an antiviral agent against animal viruses. The antiviral agent contains a protein or a nucleic acid sequence encoding the protein, as an active ingredient, the protein having binding ability and degrading ability to foreign nucleic acid chains invaded in an animal cell and that has no cytotoxicity... Agent: Invitroplant Co., Ltd.
20110201106 - Devices and methods for tissue handling and embedding: A mould and tissue cassette for automated embedding of tissue, and a method of operation are disclosed. The mould attaches to the cassette prior to embedding, and fits into a rack. The rack supports the mould holding the tissue cassette when the mould and cassette are in a first position.... Agent: Leica Biosystems Melbourne Pty Ltd
20110201108 - Isolated myeloid-like bone marrow cell populations and methods of treatment therewith: The present invention provides an isolated myeloid-like bone marrow cell population comprising a majority of cells that are lineage negative, and which express both CD44 antigen and CD11b antigen. These cells have beneficial vasculotrophic and neurotrophic activity when intraocularly administered to the eye of a mammal, particularly a mammal suffering... Agent:
20110201105 - Lactation-associated polypeptides: The invention relates to cDNA libraries obtained from Tammar wallaby (Macropus eugenii) mammary gland tissue at different times (including day 23 pregnancy, day 130 lactation, and day 260 lactation). Lactation-associated polypeptides were identified from these cDNA libraries, and bovine homologues of the wallaby proteins are also disclosed. The proteins have... Agent: Innovative Dairy Products Pty Ltd, As Trustee For The Participants Of The Cooperative Research Cente
20110201107 - Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and animals: Novel double and triple fusion reporter gene constructs harboring distinct imagable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in living cells and in living animals using distinct imaging technologies.... Agent: The Board Of Trustees Of The Leland Stanford Junior University
20110201110 - Efficient method for establishing induced pluripotent stem cells: The present invention provides a method of producing induced pluripotent stem (iPS) cells, comprising bringing a nuclear reprogramming substance into contact with dental pulp stem cells. By using dental pulp stem cells as a source of somatic cells, the efficiency of establishment of human iPS cells by transfer of 3... Agent: Kyoto University
20110201109 - Ronin is essential for perpetuity of mouse es cells, and acts independently of canonical pathways: The present invention, therefore, encompasses compositions and methods comprising Ronin, a Ronin activator, and methods of their use for maintaining the perpetuity of an ES cell phenotype.... Agent: Baylor College Of Medicine
20110201111 - Method for obtaining connective mesenchymal stem cells from the mononuclear fraction of human bone marrow: The present invention relates to a method for obtaining connective mesenchymal stem cells from the mononuclear fraction of human bone marrow cells using type AB human serum as a supplement. Said method includes the steps of obtaining said mononuclear fraction of bone marrow, the step of recovering and pre-expanding the... Agent: Banc De Sang I Teixits
20110201112 - Vault complexes for facilitating biomolecule delivery: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.... Agent: The Regents Of The University Of California
20110201113 - Ex vivo progenitor and stem cell expansion and differentiation for use in the treatment of disease of the nervous system: The present invention relates to a simplified process, which is shorter in time, for propagation of proliferating cells, such as e.g. progenitor or stem cells, by means of a biphasic culturing system having a differentiation supporting component and a proliferation supporting component, and to the use of the stem cell... Agent:
20110201114 - Manufacturing method of immune killer cells: The present invention relates to a manufacturing method of immune killer cells characterized in that an immune killer cell is induced in a culture medium containing concanavalin A (ConA), and the immune killer cell is maintained or expanded in a culture procedure. Antibody proteins are not used as a stimulant... Agent:
20110201115 - Method and apparatus for production of a skin graft and the graft produced thereby: A micro-organ structure comprising at least two micro-organ portions formed from a tissue, in which said at lest two micro-organs are linked one to the other by means of a junction formed from said tissue of which the micro-organs were formed therefrom.... Agent:
20110201116 - Test method using cells and test kit therefor: The present invention provides a method for performing a biological test under conditions in which an artificially prepared cell pattern with initial position coordinates that can be determined is three-dimensionally cultured within a gelled matrix. The present invention relates to a biological test method that comprises testing a biological indicator... Agent: Dai Nippon Printing Co., Ltd.
20110201117 - Forming porous scaffold from cellulose derivatives: Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous... Agent: Agency For Science Tecnology And Research
20110201118 - Nuclease activity of tal effector and foki fusion protein: The present invention provides compositions and methods for targeted cleavage of cellular chromatin in a region of interest and/or homologous recombination at a predetermined site in cells. Compositions include fusion polypeptides comprising a TAL effector binding domain and a cleavage domain. The cleavage domain can be from any endonuclease. In... Agent: Iowa State University Research Foundation, Inc.
20110201119 - Alphavirus packaging cell lines: This invention provides alphavirus packaging cell lines useful for commercial production of recombinant alphavirus particles and structural protein expression cassettes for making the packaging cell lines.... Agent:
20110201120 - Method for introducing gene into cell, and composition for use in the method: The present invention provides a method for transferring a gene into cells, which is practically useful and can achieve high transfer efficiency, and also a composition for use in the method. By bringing a mixture of a composition comprising a diallylamine sulfur dioxide copolymer having a repeating unit represented by... Agent: Mitsubishi Gas Chemical Company, Inc.08/11/2011 > 113 patent applications in 63 patent subcategories. inventions list
20110195394 - Systems and methods for diagnosing viral infections: Systems and methods for diagnosing viral infections. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for a viral infection in a body fluid comprising the... Agent:
20110195396 - Chewable compositions for the stabilization of diagnostic biomarkers: Chewable compositions for the stabilization of diagnostic biomarkers. In at least one embodiment of a chewing gum composition useful to stabilize a diagnostic marker, the a chewing gum composition comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker in saliva, and a... Agent:
20110195405 - Compositions, methods, and kits for analyzing dna methylation: Compositions, methods, and kits for reducing strand amplification bias using bisulfite treated gDNA are provided. Methods for detecting and for quantitating the amplified bisulfite treated gDNA and inferring the presence, absence, and/or degree of methylation of target cytosine(s) in the gDNA are also provided. Such methods typically employ tailed first... Agent: Life Technologies Corporation
20110195397 - Drink mixture for the stabilization of diagnostic biomarkers: Drink mixture for the stabilization of diagnostic biomarkers. In at least one embodiment of an ingestible beverage useful to stabilize a diagnostic marker, the rinse comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker in saliva, and a liquid.... Agent:
20110195406 - Intermittent detection during analytical reactions: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred... Agent: Pacific Biosciences Of California, Inc.
20110195407 - Nucleic acid occurring in blood from hepatitis patient, polypeptide encoded by the nucleic acid, and uses of the same: A substance associated with cryptogenic hepatitis is found and information, particularly genetic information, on the substance is provided. Also, a method for detecting the substance and a material which can be used in the method are provided. A nucleic acid is extracted from each of 500 blood samples which have... Agent: Japanese Red Cross Society
20110195395 - Rinse composition for the stabilization of diagnostic biomarkers: Rinse composition for the stabilization of diagnostic biomarkers. In at least one embodiment of a rinse useful to stabilize a diagnostic marker, the rinse comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker in saliva, and a liquid.... Agent:
20110195402 - Systems and methods for detecting drug use: Systems and methods for detecting drug use. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker indicative of drug use in a body fluid, comprising the diagnostic marker,... Agent:
20110195398 - Systems and methods for detecting insulin resistance biomarkers: Systems and methods for detecting insulin resistance biomarkers. At least one embodiment of a system of the present disclosure comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for insulin resistance or glucose intolerance in a body fluid comprising the diagnostic marker,... Agent:
20110195404 - Systems and methods for determining calcium levels: Systems and methods for determining calcium levels. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for circulating calcium in a body fluid comprising the diagnostic marker, and... Agent:
20110195401 - Systems and methods for determining food allergies: Systems and methods for determining food allergies. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for a food allergy in a body fluid comprising the diagnostic marker... Agent:
20110195400 - Systems and methods for diagnosing cancer: Systems and methods for diagnosing cancer. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for cancer in a body fluid comprising the diagnostic marker and... Agent:
20110195403 - Systems and methods for fertility analysis: Systems and methods for fertility analysis. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for fertility in a body fluid comprising the diagnostic marker, and a detection... Agent:
20110195399 - Systems and methods for the inhibition of galactose oxidase: Systems and methods for the inhibition of galactose oxidase. According to least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker by galactose oxidase in a body fluid including the... Agent:
20110195411 - Arl-1 specific antibodies and uses thereof: This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides methods of making and methods of using said antibodies.... Agent: The Board Of Trustees Of Southern Illinois University
20110195410 - Compositions and methods related to solid phase sequence detection and genotyping: The present invention provides improved compositions and methods of sequence detection and single nucleotide (“SNP”) genotyping. The methods of the present invention are related to combining sequence or allelic specific ligation on a solid phase platform with specific and efficient solid phase signal amplification. The methods for sequence detection include... Agent: Gene Check, Inc.
20110195413 - Integrated method for enriching and detecting rare cells from biological body fluid sample: The present invention relates to an integrated method for enriching and detecting rare cells in biological body fluid sample. The enriching method comprises: (a) removing plasma protein by centrifugation; (b) optionally adding a red cell lysis solution to carry out red cell lysis so as to remove the red blood... Agent: Cyttel Biosciences Co., Ltd-beijing
20110195408 - Labeling dye for detecting biomolecule, labeling kit, and method for detecting biomolecule: A labeling dye of the present invention includes a coloring portion comprising an organic EL-dye, a bonding portion to be bonded with a biomolecule and a spacer portion for linking the coloring portion and the bonding portion. The present invention provides a high incorporation ratio and also high fluorescence intensity... Agent:
20110195414 - Method and markers for determining the genotype of horned/polled cattle: Provided herein are methods to discover and use single nucleotide polymorphisms (SNP) for determining the genotype of a horned/polled ruminant subject. The present invention further provides specific nucleic acid sequences, SNPs, and SNP patterns that can be used for determining the genotype of a horned/polled ruminant subject.... Agent:
20110195412 - Predictive biomarkers for response to exercise: A set of biomarkers have been identified that allows one to predict subjects who will respond to an exercise regime in term of cardiorespiratory fitness as assessed by maximal oxygen uptake. These predictions may be used, for example, to predict risk of cardiovascular disease, to design a more effective program... Agent:
20110195409 - Streptococcus pyogenes classification: The difference Lancefield T-serotypes correlate with the sequence of the pilus backbone protein (Pbp) in Streptococcus pyogenes (GAS). We have sequenced Pbp for over 50 GAS strains, representing the major disease-associated serotypes, and have identified 15 Pbp variants. These 15 variants have been shown to determine the specificity of the... Agent: Novartis Vaccines And Diagnostics Srl
20110195417 - Device for thermally regulating a rotationally symmetrical container: The present invention relates to a device for thermally regulating a rotationally symmetrical container having a lateral surface and/or a base surface, said device comprising at least one thermal-regulation block which is suitable for accommodating the container and has at least two thermal-regulation elements, wherein the thermal-regulation elements in the... Agent: Anagnostics Bioanalysis Gmbh
20110195416 - Disease detection by digital protein truncation assays: Genetic diseases can be diagnosed by detection of mutations in causative genes. Protein truncation assays can be used to detect gene products of truncation-type mutations. However, the sensitivity of the assays is often insufficient to detect mutations present in a sample of DNA at a low frequency. Sensitivity can be... Agent: The Johns Hopkins University
20110195415 - Guanylyl cyclase c qrt-pcr: Methods, kits, compositions and systems for detecting the level of GCC encoding mRNA present in a sample using quantitative (q) RT-PCR are disclosed. The methods, kits, compositions and systems may be used to detect metastasis in patients diagnosed with primary colorectal, gastric or esophageal cancer, to predict the risk of... Agent: Thomas Jefferson University
20110195418 - Method of simultaneous detection of viroids: Methods are presented for detecting PSTVd and TCDVd viroids in plant cells and tissues using nucleic acid amplification of plant RNA with a novel primer set. The methods allow nucleic acid sequences from both types of viroid to be detected simultaneously and distinguished from each other. Also presented is a... Agent:
20110195420 - Estrogen and anti-estrogen marker genes: The invention relates to a method for screening compounds with estrogenic or anti-estrogenic activity by providing a cellular system of a sample thereof being capable of expressing at least a single gene of Table 1, incubating at least a portion of the system with compounds to be screened, and comparing... Agent: Merck Patent Gesellschaft
20110195419 - Therapeutic use of farnesyltransferase inhibitors and methods of monitoring the efficacy thereof: The therapeutic use of farnesyltransferase inhibitors (e.g., tipifarnib) for the treatment of sepsis is described. Methods useful to monitor the effectiveness of such treatment are also described.... Agent:
20110195422 - Methods for determining the efficiency of a therapeutic: Methods for determining the efficiency of a therapeutic. In at least one embodiment of a method of determining the efficacy of a therapeutic compound, the method comprises the steps of treating a subject having a disease state with an effective amount of therapeutic compound, harvesting at least one cell from... Agent:
20110195421 - Methods of identifying biomarkers for cancer: Methods of Identifying Biomarkers for Cancer. According to at least one embodiment of a method of identifying diagnostic markers of cancer of the present disclosure, the method comprises the steps of contacting a body fluid of a diseased subject having a cancer with a stabilizing agent capable of completely or... Agent:
20110195423 - Systems and methods for diagnosing bacterial infections: Systems and methods for diagnosing bacterial infections. According to at least one embodiment of a system of the present disclosure, the system a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for a bacterial infection in a body fluid comprising the diagnostic marker... Agent:
20110195424 - Systems and methods for diagnosing fungal infections: Systems and methods for diagnosing fungal infections. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for a fungal infection in a body fluid comprising the... Agent:
20110195425 - Systems and methods for diagnosing parasite infections: Systems and methods for diagnosing parasite infections. According to at least one embodiment of a stabilizing system of the present disclosure, a stabilizing system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for a parasite infection in a body fluid comprising... Agent:
20110195426 - Nucleic acids analysis: The present invention is partly based on the discovery that adverse factors can prevent an effective extraction of nucleic acids from a biological sample and that novel and unexpected agents and steps may be used to mitigate or remove the adverse factors, thereby dramatically improving the quality of the extracted... Agent: The General Hospital Corporation
20110195427 - Systems and methods for detecting pregnancy: Systems and methods for detecting pregnancy. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for pregnancy in a body fluid comprising the diagnostic marker, and a detection... Agent:
20110195428 - Composition, kit, and method for assaying ageing and disease accompanied with vascular disorder: The present invention relates to a method for detecting an ageing or a disease accompanied with a vascular disorder such as age-related macular degeneration, comprising measuring one or more of polypeptides comprising any of amino acid sequences shown in SEQ ID NOS: 1 to 21, mutants thereof, or fragments thereof... Agent: Santen Pharmaceutical Co., Ltd.
20110195430 - High pressure enzymatic digestion system for protein characterization: An on-line method and system for obtaining samples for proteomic analysis that utilizes pressure and a preselected agent to obtain a processing sample in a significantly shorter period of time than prior art methods and which maintains the integrity of the processing sample through the preparatory process, and provides enhanced... Agent: Battelle Memorial Institute
20110195429 - Methods and compositions for diagnosis and prognosis of renal injury and renal failure: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble p-selectin,... Agent: Astute Medical Inc.
20110195431 - Human orphan g protein-coupled receptors: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.... Agent: Arena Pharmaceuticals, Inc.
20110195434 - Method for the analysis of solid objects: A method of analysis or diagnosis of solid objects is based on real-time detection of how predefined probes interact with structures present on or in the solid object combined with the calculation of how the recorded binding curves of said probes are distributed in terms of interaction properties. The interaction... Agent: Ridgeview Instruments Ab
20110195433 - Methods for screening of opioid receptor neutral antagonists and inverse agonists and uses thereof: Methods for screening of opioid receptor neutral antagonists and inverse agonists and uses thereof are disclosed.... Agent: The Ohio State University Research Foundation
20110195436 - Methods for the classification and diagnosis of scoliosis through the use of gi protein receptor: Methods for diagnosing a predisposition to developing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protein-coupled receptor activity are described. Specific embodiments of the methods involve measuring a change in impedance signals of cells expressing a receptor coupled to... Agent:
20110195435 - Use of a protein kinase inhibitor to detect immune cells, such as t cells: The invention relates to a method for sorting, staining or detecting T cells of the immune system using a protein kinase inhibitor.... Agent:
20110195432 - Methods for the selection of therapeutic treatments for cancer: Methods are disclosed for identifying subjects that would benefit from treatment with an inhibitor of HDAC6 deacetylase activity. The methods can include contacting a sample obtained from the subject with an of HDAC6 deacetylase activity detecting the amount of HDAC6 protein present in the tumor sample in comparison with a... Agent:
20110195438 - Insulin assay: The present invention provides an insulin-specific assay and an assay reagent capable of sensitively and specifically assaying insulin using an antibody having a property of reacting with insulin bound to an anti-insulin antibody while not reacting with insulin not bound to an anti-insulin antibody, without being affected by proinsulin and... Agent:
20110195437 - Method for characterizing, in particular for quantifying, molecular markers that are intracellularly absorbed from tissues by blood macrophages that are recirculated from the tissues into the circulatory system: The invention relates to a method for characterizing, in particular for quantifying molecular marker(s) that are intracellularly absorbed from tissues by blood macrophages that are recirculated from the tissues into the circulatory system, wherein the following steps are carried out: application of an agent to whole blood, said agent inhibiting... Agent: Synmed Research Gmbh
20110195439 - Systems and methods for determining cardiac conditions: Systems and methods for determining cardiac conditions. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for cardiovascular disease in a body fluid comprising the diagnostic... Agent:
20110195440 - Systems and methods for identifying allergies: Systems and methods for identifying allergies. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for a non-food allergy in a body fluid comprising the diagnostic marker and... Agent:
20110195441 - method and assembly for measuring thrombin generation in plasma: Disclosed is a method for measuring thrombin generation in a whole blood sample. The whole blood sample may be applied forthwith, without prior processing. The blood cells and blood plasma in the whole blood sample are separated by (lateral) flow migration. Also disclosed is an assembly of a sample support... Agent:
20110195442 - Sterility indicating biological compositions, articles and methods: A sterility indicating composition comprising a plurality of sterilization process resistant spores which contain an active protease during germination and initial outgrowth of the spores; and a germination medium comprising at least one labeled protease substrate and at least one nutrient for germination of the spores; wherein the medium is... Agent:
20110195443 - Screening method for identifying protease secretion-deficient mutants of microorganisms: A method for identifying a protease secretion deficient strain of a microorganism involves producing a mutant of the microorganism, followed by adding the mutant to gel-filled wells of a microtitration plate, incubating the mutant in the gel-filled wells under conditions call sing the mutant to secrete proteins, separating the mutant... Agent: Cilian Ag.
20110195444 - Novel protein having fructosyl valyl histidine oxidase activity, modified protein, and use of the protein or the modified protein: The present invention provides: a protein having a fructosyl amino acid oxidase activity which protein is useful for measurement of a glycosylated protein (particularly, glycosylated hemoglobin); a modified protein thereof; and use of the protein or the modified protein. The protein of the present invention is, for example, a fructosyl... Agent: Gekkeikan Sake Co., Ltd.
20110195446 - Method and kit for semen diagnosis through color changes in methylene blue and semen quality evaluation using same: The present invention relates to a method and a kit for diagnosis of semen quality (motility and concentration) through observation of color change visible with the naked eye in a solution combining methylene blue and sperm. The invention comprises a method for semen diagnosis using color coding (with a standard... Agent:
20110195445 - Methods and systems for fluid examination and remediation: A system for in situ monitoring within a specified environment includes a housing with an intake inserted into the environment. A plurality of pumps are included in the housing with a number of test beds, each being separately coupled to one of the number of pumps, where each of the... Agent:
20110195447 - Identification of non-small cell lung carcinoma (nsclc) tumors expressing pdgfr-alpha: The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRα) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRα is... Agent: Cell Signaling Technology, Inc.
20110195449 - Recombinant thraustochytrids that grow on sucrose, and compositions, methods of making, and uses thereof: The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.... Agent: Martek Biosciences Corporation
20110195448 - Recombinant thraustochytrids that grow on xylose, and compositions, methods of making, and uses thereof: The present invention is directed to recombinant thraustochytrids that grow on xylose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.... Agent:
20110195450 - In vitro protein synthesis systems for membrane proteins that include adolipoproteins and phospholipid adolipoprotein particles: In vitro protein synthesis systems and methods are provided that produce membrane proteins in soluble form. In some aspects, the invention provides methods of synthesizing proteins using in vitro protein synthesis systems that include an apolipoprotein, in which higher yields of soluble protein are produced than in the absence of... Agent: Life Technologies Corporation
20110195451 - Protein expression: An isolated DNA molecule having a sequence which comprises in a 5′ to 3′ direction (i) one or more promoter elements, (ii) the geneof interest, and (iii) a poly-adenylation 5 signal, and (iv) a terminator element, and expressing the geneof interest incorporated into the DNA molecule in an expression system,... Agent: Isis Innovation Limited
20110195452 - set of sequences for targeting expression and control of the post-translational modification of a recombinant polypeptide: The present invention provides new tools useful for controlling the post-translational modifications of recombinant polypeptides. These tools are particular signal peptides allowing the targeting of recombinant polypeptides during their synthesis in a host cell to specific sub-cellular compartments and a specific designing of said recombinant polypeptides within said sub-cellular compartments.... Agent: Centre National De La Recherche Scientific-cnrs
20110195453 - Antibodies specific for sclerostin and methods for increasing bone mineralization: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density... Agent: Ucb Manufacturing, Inc.
20110195454 - Common light chain mouse: A genetically modified mouse is provided, wherein the mouse is incapable of rearranging and expressing an endogenous mouse immunoglobulin light chain variable sequence, wherein the mouse expresses only one or two human light chain variable domains encoded by human immunoglobulin sequences operably linked to the mouse kappa (κ) constant gene... Agent: Regeneron Pharmaceuticals, Inc.
20110195455 - Nucleic acids encoding human anti-il-23 antibodies: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.... Agent:
20110195456 - Methods and compositions for the production of monoclonal antibodies: The present invention comprises compositions and methods for making monoclonal antibodies. The present invention further comprises vectors that replicate the immune system components, particularly an antigen-presenting cell (APC) element of the immune synapse. Additionally, the present invention may further comprise synthetic T-cells.... Agent:
20110195457 - Isothermal amplification of nucleic acid using primers comprising a randomized sequence and specific primers and uses thereof: Methods and kits for amplifying a nucleic acid under isothermal conditions to form an amplified nucleic acid sequence are provided. The methods and kits comprises providing a nucleic acid template, a DNA polymerase, deoxyribonucleoside triphosphates, a primer comprising a randomized sequence, and a specific primer, and amplifying the nucleic acid... Agent: General Electric Company
20110195458 - Method and apparatus for amplifying nucleic acid sequences: A method of amplifying one or more target nucleic acid sequence(s) in a PCR buffer solution comprising one or more target nucleic acid sequence(s), a nucleic acid polymerase, deoxynucleotide or nucleotide triphosphates, at least a first primer and a second primer is provided. The PCR buffer solution is contained in... Agent: Ludwig-maximilians-universitat Munchen
20110195459 - Methods of making libraries of nucleic acids using porous particles: The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles... Agent: Life Technologies Corporation
20110195460 - Methods and kits for nucleic acid amplification: Compositions and methods are provided for amplifying nucleic acid molecules. The nucleic acid molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays.... Agent: Genisphere, LLC
20110195461 - Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol: The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2... Agent:
20110195462 - System and method for producing biomaterials: A bioreactor system for manufacturing and extracting a desired biomaterial from a microorganism by fermenting the microorganism in the bioreactor. The system includes a horizontal reactor vessel, one or more vertical discs rotatably mounted around a hollow shaft, a motor to power the shaft, and one or more spray nozzles... Agent: Renewable Process Technologies, LLC
20110195464 - Biocatalysts and methods for conversion of hemicellulose hydrolysates to biobased products: The invention relates to processes and biocatalysts for producing ethanol and other useful products from biomass and/or other materials. Initial processing of lignocellulosic biomass frequently yields methylglucuronoxylose (MeGAX) and related products which are resistant to further processing by common biocatalysts. Strains of Enterobacter asburiae are shown to be useful in... Agent: University Of Florida Research Foundation, Inc.
20110195463 - Novel thermophilic endo-glucanase and uses thereof: A novel thermophilic endo-glucanase, nucleic acid encoding the endo-glucase, and uses thereof in converting ligocellulosic material to fermentable sugars.... Agent: Academia Sinica
20110195465 - Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor: The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure... Agent: Codexis, Inc.
20110195466 - Microorganisms for the production of adipic acid and other compounds: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or... Agent: Genomatica, Inc.
20110195467 - Method for fermentative production of menaquinone-7 using escherichia coli: The invention relates to a method of producing menaquinone-7, characterized in that cells of an E. coli strain comprising the B. subtilis DSM 1088 hepS gene, the B. subtilis DSM 1088 hepT gene and the putative B. subtilis DSM 1088 heptaprenyl transferase gene are fermented in a fermentation medium, with... Agent: Wacker Chemie Ag
20110195468 - system and process for separating pure chemicals from biomass extract: A system or plant and method for the production of pure alcohol, acetic acid or its derivatives from the extract containing hemicelluloses filtered after extraction of woody biomass or directly extracted from woody biomass. The process can be integrated with the host plant process to minimize the effect of loss... Agent: American Process, Inc.
20110195469 - Microbial production of fatty alcohols: Genes and strains of recombinant microorganisms are provided that are engineered to produce fatty alcohols and fatty alcohol derivatives. The organisms can include one, two, three or more transgenes that direct the biosynthesis of one or more fatty alcohols or derivatives. Methods of producing fatty alcohols using transgenic microorganisms are... Agent: Synthetic Genomics, Inc.
20110195470 - Production of isoprenoids: The invention provides a biological method of producing isoprenoids.... Agent: Arkion Life Sciences, LLC
20110195471 - Production of biodiesel, cellulosic sugars, and peptides from the simultaneous esterification and alcoholysis/hydrolysis of materials with oil-containing substituents including phospholipids and cellulosic and peptidic content: The present invention relates to a method for producing fatty acid alkyl esters as well as cellulosic simplified sugars, shortened protein polymers, amino acids, or combination thereof resulting from the simultaneous esterification and hydrolysis, alcoholysis, or both of algae and other oil containing materials containing free fatty acids (FFA), glycerides,... Agent: Inventure Chemical, Inc.
20110195472 - Membrane bioreactor for increased production of isoprene gas: The invention provides improved methods for the production of isoprene from biological materials.... Agent:
20110195473 - Method and device for photosynthesis-supported exhaust gas disposal, particularly co2: The invention relates to a method and to a device for photosynthesis-supported exhaust gas disposal, particularly CO2 disposal. In order to compensate, even locally, for CO2 produced by energy generation or by processing energy carriers, the invention proposes that exhaust gases from combustion processes or chemical processes act as a... Agent:
20110195474 - Methods of using a multiple sheath flow device for the production of microcapsules: The present invention provides methods for preparing micro-capsules, each microcapsule comprising a semipermeable membrane, an aqueous core, one or more enzymes in the aqueous core, and one nucleic acid template in the aqueous core. Microcapsules are prepared by flowing (i) an innermost fluid flow comprising at least one enzyme and... Agent: Genome Corporation
20110195475 - Artificial enzymes: The present invention is directed to the use of artificial polymers in the mimetization of enzymatic active sites and the carrying-out of catalysis using these artificial enzymes. Further, as used herein, an artificial enzyme refers more generally to a polymer-based scaffold for presenting specific chemically active atoms optimally for reactions,... Agent:
20110195476 - Modified chondroitin synthase polypeptide and crystal thereof: Disclosed are: (A) a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, or (B) a polypeptide comprising an amino acid sequence of SEQ ID NO:2 including deletion, substitution or addition of one or several amino acid residues and having chondroitin synthase activity; a nucleic acid encoding the... Agent: Seikagaku Corporation
20110195477 - Microcapsules and methods of use for amplification and sequencing: The present invention discloses thermostable microcapsules comprising a semipermeable membrane, an aqueous core, one or more enzymes in the aqueous core, and a nucleic acid template for an enzyme-mediated reaction in the aqueous core. In one embodiment of the invention, the aqueous core contains one or more polymerases. Microcapsules of... Agent: Genome Corporation
20110195478 - Bladder cancer biomarker and test method using the same: The present invention discloses a bladder cancer biomarker and a test method using the same. The biomarker contains at least one of the mentioned 69 compounds, such as apolipoprotein A1 (APOA1), apolipoprotein A2 (APOA2), peroxiredoxin 2 (PRDX2), heparin cofactor 2 precursor (HCII), and serum amyloid A-4 protein (SAA4), which exist... Agent:
20110195479 - Polymerase: The invention relates to thermostable polymerases that have polymerase activity temperatures in the range from 90.degree. C. up to 113.degree. C., such as those derived from Pyrolobus fumaria, and to polynucleotides encoding the polymerases In addition, methods of designing new thermostable DNA polymerases and methods of use thereof are also... Agent: Verenium Corporation
20110195480 - Production of hemagglutinin-neuraminidase protein in microalgae: The present invention is directed to recombinant microalgal cells and their use in production of heterologous hemagglutinin-neuraminidase (HN) polypeptides, as well as compositions and uses thereof.... Agent:
20110195481 - Variants and compositions comprising variants with high stability in presence of a chelating agent: The present invention relates to variants of an alpha-amylase having improved stability to chelating agents relative to its parent enzyme, compositions comprising the variants, nucleic acids encoding the variants, methods of producing the variants, and methods for using the variants.... Agent: Novozymes A/s
20110195482 - Serine protease isolated from the venom of bombus ignitus as fibrinogenolytic and fibrinolytic enzymes: Disclosed is serine protease isolated from Bombus ignitus, a bumble bee, capable of activating prothrombins and degrading fibrinogens and fibrins. Since the serine protease of the present invention enables to activate the prothrombin and directly degrade fibrinogens and fibrins it can be used in the development of a therapeutic agent... Agent: Dong-a University Research Foundation For Industry-academy Cooperation
20110195483 - Non-natural amino acid replication-dependent microorganisms and vaccines: Compositions and methods of producing vaccines, including methods wherein whole organism vaccines are provided with limited replication abilities, thereby increasing vaccine safety and efficacy, through the use of non-natural, unnatural, or non-naturally encoded amino acids.... Agent: Ambrx, Inc.
20110195484 - Methods of and systems for dewatering algae and recycling water therefrom: A method of dewatering algae and recycling water therefrom is presented. A method of dewatering a wet algal cell culture includes removing liquid from an algal cell culture to obtain a wet algal biomass having a lower liquid content than the algal cell culture. At least a portion of the... Agent: Heliae Development, LLC
20110195485 - Methods of and systems for producing biofuels: A method for producing biofuels is provided. A method of making biofuels includes dewatering substantially intact algal cells to make an algal biomass, extracting neutral lipids from the algal biomass, and esterifying the neutral lipids with a catalyst in the presence of an alcohol. The method also includes separating a... Agent: Heliae Development, LLC
20110195486 - Methods for removing nucleic acid contamination from reagents: In general, the disclosed method can be used to remove contaminating microbes and nucleic acids from microorganisms-derived reagents, apparatus and processes (materials and apparatus) related to PCR (and RT-PCR), including sample prep reagents and materials that are used to isolate, purify and detect nucleic acids.... Agent: Life Technologies Corporation
20110195488 - Devices for collection and stabilization of biomarkers in liquid samples: Device for collection and stabilization of biomarkers in liquid samples. In at least one embodiment of a fluid collection device, the device comprises a first tube operable to receive a body fluid, a second tube operable to dispense a body fluid, and a suction device operably connected to the second... Agent:
20110195487 - Sample container for biomarker maintenance: Sample container for biomarker maintenance. In at least one embodiment of a system for stabilizing a diagnostic marker of the present disclosure, the system comprises a sample container having an opening and least one rigid chamber for containing a body fluid, the body fluid comprising at least one diagnostic marker,... Agent:
20110195489 - System and method of an in-vitro wound healing model on cultured cell monolayer employing stamp device: A system and method of an in vitro wounding model that employs a wounding device compromising a stamp assembly with a stamp disk engraved with alternating grooves and ridges, to dislodge cells of cultured cell monolayer. Strips or islands of cells are left behind, which can be used for morphological... Agent:
20110195490 - Cartridge for apparatus for chemically analyzing blood and apparatus using the same: The present invention provides a cartridge for an apparatus for analyzing blood chemistry that is used for medical treatment, and automatically analyzes and records data needed for medical service, such as the concentrations of electrolytes, the partial pressures of gases, and the concentrations of metabolites, or the volume ratio of... Agent: I-sens Inc.
20110195491 - Devices and systems for biomarker detection: Devices and systems for biomarker detection. In at least one embodiment of a device for analyzing the presence or absence of a diagnostic marker to be detected in a body fluid, the device comprises a container, wherein the container houses a sample reservoir having a sample input port in fluid... Agent:
20110195492 - Optical apparatus: An optical apparatus for illuminating particles and for detecting emissions from illuminated particles in a flow cytometer having an optical configuration aligned with a flow or particles.... Agent: Xy, LLC
20110195493 - Continuous system for converting co2 into high value-added and/or nutritional value products and energy resources: A system for generating high value-added or nutritional value products and other energy resources comprising first production means for culturing at least one phytoplankton culture and means for naturally and/or artificially illuminating the phytoplankton culture to induce growth and/or multiplication of the culture, wherein the systems allows for illuminating the... Agent: Bio Fuel Systems, S.l.
20110195494 - Dll4-binging molecules: DII4-binding molecules, preferably DII4-binding immunoglobulin single variable domains like VHHs and VHs, pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with DII4-mediated effects on angiogenesis. Bispecific DII4-binding molecules that also bind to VEGF-A. Nucleic acids encoding DII4-binding molecules, host cells and methods for... Agent: Boehringer Ingelheim International Gmbh
20110195496 - Microwell array chip and method of manufacturing same: The present invention is directed to a microwell array chip made of silicon and having multiple microwells. Each microwell is used to store a single specimen organic cell. Each microwell is of a size and shape holding just one organic cell, and the interior surface of the microwells are coated... Agent:
20110195495 - Nucleic acid purification: The inventive self-contained apparatus for isolating nucleic acid, cell lysates and cell suspensions from unprocessed samples apparatus, to be used with an instrument, comprises at least one input, and: (i) a macrofluidic component, comprising a chamber for receiving said unprocessed sample from a collection device and at least one filled... Agent: Netbio, Inc.
20110195498 - Liquid crystalline substrates for culturing cells: The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.... Agent: Wisconsin Alumni Research Foundation
20110195497 - Method for purifying mesenchymal stem cells: The invention relates to a method for purifying mesenchymal stem cells, producing cells corresponding to prior art, the cells obtained being characterised by an increased proliferation capacity while maintaining the multipotency and typical antigen characteristics. To this end, mesenchymal stem cells that can be multiplied in a significantly improved manner... Agent:
20110195500 - Methods and compositions for mitigating eosinophilic esophagitis by modulating levels and activity of eotaxin-3: Eotaxin-3, as a marker for eosinophilic esophagitis and methods of assessing, mitigating, and monitoring eosinophilic esophagitis by altering eotaxin-3 and/or CCR3 function, are disclosed.... Agent: Children's Hospital Medical Center
20110195501 - Ultrasonically induced release from polymer vesicles: Disclosed are methods of controllably permeabilizing polymersomes. Such methods are useful in permeabilizing polymersomes so as to effect controlled release of therapeutic or imaging agents to a particular location. Also disclosed are systems for controllably delivering various agents to particular locations via polymersomes and related polymersome-based methods for treating diseases... Agent:
20110195499 - Utility of ret mutant in diagnosis and treatment of melanoma: The invention relates to a method of detecting a RET mutant in a melanoma cell. Also disclosed is a method of modulating the activity of a RET mutant in a melanoma cell with an agent that interferes with the activity of the RET mutant.... Agent:
20110195502 - Centrifugal rotor and method for using the same for delivering biological sample: Disclosed herein is a centrifugal rotor for delivering and analyzing biological sample. Chambers within the centrifugal rotor is used to split a biological sample, which comprises biological cellular components and biological fluids, into separate parts under centrifugal force after the biological sample being diluted, metered and distributed by the centrifugal... Agent: Medi Medical Engineering Corp.
20110195503 - Gold nanoparticle, a composition and a method to perpetuate stemness thereof: The present invention relates to gold nanoparticle (GNP) and a method to perpetuate stemness of stem cells comprising step of growing the stem cells in presence of gold particle or Swarna Bhasma. It also relates to compositions for perpetuating stemness of stem cells.... Agent: Stempeutics Research Private Limited.
20110195504 - Tubulo-vesicular structure localization signals: The invention relates to polarized cell tubulo-vesicular structure localization signals. The localization signals are utilized as research tools or are linked to polypeptides of interest or therapeutic molecules. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins and/or other... Agent: Intrexon Corporation
20110195505 - Bacterial strains for butanol production: Bacteria that are not natural butanol producers were found to have increased tolerance to butanol when the saturated fatty acids content in bacterial cell membrane was increased. Methods for increasing the concentration of saturated fatty acids in the membranes of bacteria that are not natural butanol produces are described whereby... Agent: Butamax(tm) Advanced Biofuels LLC
20110195506 - Method for producing yeast expressed hpv types 6 and 16 capsid proteins: Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production of conformational... Agent:08/04/2011 > 129 patent applications in 60 patent subcategories. inventions list
20110189648 - Post-thaw survival of cryopreserved biological material by hydrostatic pressure challenge: The present invention relates to a method for improving post-thaw survival of cryopreserved biological material comprising applying hydrostatic pressure to said biological material; keeping the said biological material at the hydrostatic pressure for a predetermined time period; releasing the hydrostatic pressure; and freezing the said biological material using any protocol... Agent:
20110189649 - Laboratory apparatus for a controlled environment: A controlled environment system for use in IVF, ICSI or other biological procedures has a main chamber containing one or more manipulator devices and a microscopy viewing system enabling viewing of the manipulation procedure. The proportions of gas in a multi gas chamber atmosphere set up in the main chamber... Agent:
20110189650 - Microfluidic cell sorter with electroporation: A biological particle manipulating device and method of its use. The device includes structure arranged to urge biological particles into substantially single file travel through an interrogation zone. Operable alignment structure nonexclusively include sheathed fluid flow, capillary tubes, an orifice, and fluid microchannels. One or more detector, selected from a... Agent:
20110189653 - Detection and prognosis of cervical cancer: The present invention relates to methods and kits for identifying, diagnosing, prognosing, and monitoring cervical cancer. These methods include determining the methylation status or the expression levels of particular genes, or a combination thereof.... Agent:
20110189654 - Diagnostic reagent, containing bioparticles, method for production thereof and use thereof as internal standard in nucleic acid preparation and nucleic acid detection methods: A diagnostic reagent in the form of a composition dimensionally stable under standard conditions, comprising bioparticles and also customary pharmaceutical excipients, wherein the bioparticles are selected from the group consisting of bacteria, viruses, fungi, protozoa, bacteriophages, yeasts, spores, parasites, plant cells, animal or human cells, gametes, plasmids, and viroids.... Agent: Qiagen Gmbh
20110189651 - Method and device for detecting feline immunodeficiency virus: A method and device for determining a feline immunodeficiency virus infection or vaccination in an animal. The method includes contacting a biological sample from a felid with various FIV polypeptides and determining the binding of antibodies in the sample to the polypeptides. The determination of whether an animal is infected... Agent: Idexx Laboratories, Inc.
20110189656 - Method for determining presence or absence of abnormal cell: A method for determining the presence or absence of an abnormal cell in a sample collected from the uterine cervix of a subject, and a method for predicting the progression of a lesion in the uterine cervix in a subject, each of which comprises measuring the frequency of methylation in... Agent:
20110189655 - Reagents and kits for detection of influenza virus and the like: The present invention relates to reagents and methods for influenza virus detection. These reagents and methods disclosed in the present invention enable simple, rapid, specific and sensitive detection of influenza virus types A and B. These reagents are N-acetylneuraminic acid-firefly luciferin conjugates which can be cleaved by influenza virus neuraminidase.... Agent:
20110189652 - Viral variants with altered susceptability to nucloeside analogs and uses thereof: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components... Agent:
20110189660 - Biochip, sample reaction apparatus, and sample reaction method: A biochip includes: a first chamber; a second chamber filled with a wax, a melting point of the wax being 25° C. or more and 63° C. or less; an injection path between the first chamber and the second chamber; and a sub-chamber that includes a wall at least partially... Agent: Seiko Epson Corporation
20110189658 - Cell, method and kit for conducting an assay for neutralizing antibodies: The present invention provides a cell for use in a one-step cell-based assay for an extracellular ligand (e.g., I FNα) that initiates a ligand-specific signal at the nucleus of the cell and for neutralizing antibodies against the extracellular ligand. The cell-based one-step assay allows both the extracellular ligand concentration and... Agent: Biomonitor Limited
20110189657 - Device and a method for the detection and amplification of a signal: The invention relates to a device and a method for the detection and amplification of a primary signal, utilizing an intracellular communication system, and the use thereof for the detection of substances such as phosphorus, sulfur, nitrogen, hormones, metabolic intermediates, fermentation products, and so forth. The device according to the... Agent: Technische Universitaet Dresden
20110189659 - Generation of modified polymerases for improved accuracy in single molecule sequencing: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions and/or heterologous or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include reduced reaction rates at one or more steps of the polymerase kinetic cycle, increased closed... Agent: Pacific Biosciences Of California, Inc.
20110189661 - Gravity-assisted mixing methods: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included... Agent: Qualigen, Inc.
20110189662 - Method for measuring survivin mrna: Disclosed is a method of amplifying and detecting mRNA of survivin gene in an RNA amplification process comprising: a step for forming a double-stranded DNA containing a promoter sequence by use of a combination of oligonucleotides consisting of a first primer having a sequence homologous with a portion of survivin... Agent: Tosoh Corporation
20110189663 - Assessment of risk for colorectal cancer: Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).... Agent: Mcgill University
20110189670 - Circulating tumor and tumor stem cell detection using genomic specific probes: The present invention comprises a method of detecting circular tumor cells and methods of detecting, evaluating, or staging cancer in a patient, as well as a method of monitoring treatment of cancer in a patient using the claimed method. The method comprises contacting a sample with a CD45 binding agent;... Agent:
20110189676 - Compositions for use in identification of fungi: The present invention relates generally to identification of fungi pathogens, and provides methods, compositions, systems and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent:
20110189672 - Diagnostic methods involving determining gene copy numbers and snps in the fcyrll/fcyrlll gene cluster, and probes for use in such methods to detect susceptibility to and treatment efficacy in autoimmune diseases: The invention relates to diagnostic methods to predict whether a subject is predisposed for acquiring a disease or to predict the therapy responsiveness of an individual patient. Provided is a method for determining whether a subject is predisposed for developing an autoimmune disease, comprising determining in a sample isolated from... Agent: Stichting Sanquin Bloedvoorziening
20110189664 - Diagnostics in a monoplex/multiplex format: The present invention relates to a method of detecting and/or quantifying a target molecule from a sample obtained from a subject wherein the method comprises: (i) incubating a fusion protein or conjugate comprising a Ter binding polypeptide fused to at least one anti-target molecule or fragment thereof with a partially... Agent: University Of Wollongong
20110189675 - Method for administering anticoagulation therapy: The present invention provides a method for use in treating a patient with an anticoagulant to optimize drug therapy and/or to prevent an adverse drug response. More particularly, the present invention relates to a method and system for use in treating a patient with Coumadin® or a substance containing warfarin.... Agent: Marshfield Clinic
20110189674 - Method for quantifying or detecting dna: The present invention relates to a method for quantifying or detecting DNA having a target DNA region, and so on.... Agent: Sumitomo Chemical Company, Limited
20110189667 - Method of screening for novel exon 1 mutations in mecp2 associated with classical rett syndrome: Recently, a new MECP2 isoform, which has an alternative N-terminus, transcribed from exon 1, was described. Since the incorporation of exon 1 into standard sequencing protocol for Rett syndrome, few patients with exon 1 mutations have been described and several groups have concluded that exon 1 mutations are a rare... Agent: The Children's Mercy Hospital
20110189665 - Methods for detecting drug-resistant microbes: The present invention provides methods and oligonucleotides for detecting drug-resistant microbes, such as vancomycin resistant Enterococcus spp., in a sample.... Agent:
20110189668 - Methods for determining likelihood of longevity and of developing an age-related disease: The present invention provides a method for identifying a subject's likelihood of achieving longevity or of developing an age-related disease, the method for identifying a subject's likelihood of achieving longevity or of developing an age-related disease comprising detecting at least one specified single nucleotide polymorphisms or genotype at a single... Agent:
20110189669 - Methods of aiding in the diagnosis of prostate cancer: The current invention provides a method for aiding in the assessment of prostate cancer (including metastatic prostate cancer) and/or benign prostate hyperplasia in a patient, wherein the method comprises the step of determining the level of Glycine N-methyltransferase (GNMT) nucleic acid and/or protein in a sample from the patient. The... Agent: Imperial Innovations Limited
20110189666 - Nucleic acid probe set and method of using the same: A nucleic acid probe set includes (A) a fluorescent probe and (B) a binding probe. The fluorescent probe (A) is formed of an oligonucleotide including (a) a nucleotide labeled with a fluorescent substance. The binding probe (B) is formed of an oligonucleotide having (b1) a fluorescent probe binding region, to... Agent: Nippon Steel Kankyo Engineering Co., Ltd
20110189671 - Nucleoside triphosphate derivative, nucleic acid probe, multilabeled nucleic acid probe, method for production of multilabeled nucleic acid probe, and method for detection of target nucleic acid: A novel nucleoside triphosphate derivative, a nucleic acid probe, and a multilabeled nucleic acid probe that can detect a target nucleic acid conveniently and with high sensitivity, as well as a method for producing the multilabeled nucleic acid probe, and a method for detecting a target nucleic acid using the... Agent: Aloka Co., Ltd.
20110189673 - Stool sample preparation method, solution for preparing stool sample and stool collection kit: The present invention relates to the providing of a method for preparing a stool sample that enables nucleic acids in a stool to be stably preserved without requiring a complex procedure, a stool sample preparation solution and stool collection kit used in that method, and a method for recovering and... Agent: Olympus Corporation
20110189679 - Compositions and methods for whole transcriptome analysis: The present invention provides methods and compositions, including kits, for the generation of cDNA from mRNA with reduced ribosomal RNA representation.... Agent: Nugen Technologies, Inc.
20110189684 - Method for determining drug resistance mutations in any of the non-structural protein regions ns3 to ns5b of hepatitis c virus (hcv) for genotypes 1 to 6: The present invention relates to a method for determining drug resistance mutations in any of the non-structural protein regions NS3 to NS5B of Hepatitis C Virus (HCV) for genotypes 1 to 6, more in particular for subtype specific genotypes 1a, 1b, 2a, 2b, 3a, 4a and 4d.... Agent:
20110189683 - Method of nucleic acids analysis by real-time polymerase chain reaction and device for performing the same: The invention refers to molecular biology, medicine, biotechnology and is related to performance of Polymerase Chain Reaction and device for its implementation with real-time registration of reaction-product build-up. The task of the invention is solved as a result of using the method and device for its implementation for identification of... Agent: Lumex Instruments Limited
20110189677 - Methods for preparing sequencing libraries: Improvements in chromatin immunoprecipitation-high throughput sequencing techniques has allowed the creation of chromatin maps from limited biological sample sizes that cannot be evaluated using conventional chromatin immunoprecipitation-sequencing protocols. For example, a modified universal primer is utilized that incorporates restriction enzymes into chromatin immunoprecipitation fragments before amplification. The improved method allows... Agent: Massachusetts Institute Of Technology
20110189680 - Methods of diagnosing rejection of a kidney allograft using genomic or proteomic expression profiling: A method of determining the acute allograft rejection status of a subject, the method comprising the steps of: determining the nucleic acid expression profile of one or more than one nucleic acid markers, or one or more than one proteomic markers in a biological sample from the subject; comparing the... Agent: The University Of British Columbia
20110189685 - Methods of using jak3 genetic variants to diagnose and predict crohn's disease: The present invention relates to methods of diagnosing and diagnosing susceptibility to Crohn's Disease by determining the presence or absence of risk variants at the JAK3 locus. In one embodiment, the present invention provides a method of diagnosing susceptibility to Crohn's Disease by determining the presence of a risk variant... Agent: Cedars-sinai Medical Center
20110189678 - Microfluidic device and methods of using same: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited... Agent: Fluidigm Corporation
20110189681 - Stat3 and tyk2 as drug targets for neurodegenerative diseases: The invention provides Stat3 and Tyk2 targets that have importance for diagnosis of neurode-generative diseases such as Alzheimer's disease. Stat3 and Tyk2 are also important as targets for drug development for neurodegenerative diseases.... Agent: Biotechnology Research Corporation Limited
20110189682 - Tools for objectively determining severity of systemic sclerosis: Methods are disclosed for the identification and use of biomarkers in order to objectively measure systemic sclerosis. The biomarker may be a single gene, or may be a combination of multiple genes. A preferred embodiment in which the biomarker is a four gene combination of two TGFβ regulated genes (COMP... Agent:
20110189686 - Screening for modulators of cyp2b15 and/or gpd1 for the treatment of acne, of seborrhoeic dermatitis or of hyperseborrhoea: An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the CYP2B15 and/or glycerol-3-phosphate dehydrogenase... Agent: Galderma Research & Development
20110189687 - Compositions for use in identification of members of the bacterial genus mycoplasma: The present invention relates generally to identification of members of the bacterial class Mollicutes or the bacterial genus Mycoplasma and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent: Ibis Bioscience, Inc.
20110189688 - Genes: The invention relates to mutations in B-Raf gene products. The mutations described are identified in human tumours of natural origin. These mutations are associated with cancerous phenotypes and can be used as a basis for the diagnosis of cancer, cancerous cells or a predisposition to cancer in human subjects, and... Agent: The Wellcome Trust
20110189690 - Antibody complex, method for detecting antigen, and method for producing anitbody complex: In order to improve the detection sensitivity of MUSTag, the present invention provides an antibody complex including a nucleic acid chain as a label, an antibody to specifically recognize the antigen and an adaptor moiety linking the nucleic acid chain and the antibody, wherein the adaptor moiety includes an immunoglobulin... Agent: Synthera Technologies Co., Ltd.
20110189689 - Riboswitches: The TPP riboswitch is a target for antibiotics, herbicides, algicides, fungicides and other utilities. The atomic structure of the binding pocket of the TPP riboswitch has been resolved. Compounds identified and optimized using this information can be used to stimulate, activate, inhibit and/or inactivate the TPP riboswitch.... Agent:
20110189692 - Assay for pathogenic conformers: The invention provides methods for detecting the presence of a non-prion pathogenic conformer in a sample by contacting the sample suspected of containing a non-prion pathogenic conformer with a pathogenic conformer-specific binding reagent under conditions that allow the binding of the reagent to the pathogenic conformer, if present; and detecting... Agent: Novartis Ag
20110189691 - Gene and protein expression profiles associated with the therapeutic efficacy of egfr-tk inhibitors: The present invention provides protein and gene expression profiles indicative of whether a patient afflicted with non-small cell lung cancer is likely to be responsive to treatment with a therapeutic compound that is a EGFR-TK inhibitor. By identifying such responsiveness, a treatment provider may determine in advance those patients who... Agent: Nuclea Biomarkers, LLC
20110189693 - Methods for cancer diagnosis, anti-cancer drug screening, and test of drug effectiveness on the basis of phoshorylation of ras at thr-144 and thr-148: Methods of diagnosing cancer and screening for an anti-cancer drug using Ras are provided. Ras has a very significant role as a prevalent proto-oncogene which has abnormalities in most forms of cancer, and thus the methods of diagnosing cancer and screening for an anti-cancer drug using Ras may be applied... Agent: Industry-academic Cooperation Foundation, Yonsei University
20110189694 - Methods for detection and diagnosis of a bone or cartilage disorder: The present invention is directed to methods for the detection and diagnosis of bone and/or cartilage disorders, wherein the level of expression of a polypeptide in a test sample is measured by contacting the test sample with an antibody that specifically binds to said polypeptide and measuring the binding of... Agent: Biomarker Design Forschungs Gmbh
20110189695 - Method and device for producing metal-containing organic compounds: The invention relates to a method and to a device for producing conjugates comprising or consisting of a metallic nanoparticulate component and an organic component. Said method enables activated or reactive nanoparticles containing metal to be produced by irradiating a metal body with a laser beam and prevents the modification... Agent: Laser Zentrum Hannover E.v.
20110189696 - Monoclonal antibody stro-4: The present invention relates to a monoclonal antibody designated STRO-4 which specifically binds human and ovine HSP-90beta and its use for enriching multipotential cells such a mesenchymal precursor cells (MPCs).... Agent:
20110189703 - High throughput cell-based assays, methods of use and kits: In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation. The cells are then examined to detect the bound ligand. To perform the washing step(s) the... Agent: Millipore Corporation
20110189702 - Photoluminescent materials for multiphoton imaging: Disclosed are nano-sized materials that can exhibit luminescence in a multi-photon imaging technique. The materials include a nano-sized particle or a carbon nanotube and a passivation agent bound to the surface of the nanoparticle or nanotube. The passivation agent can be, for instance, a polymeric material. The passivation agent can... Agent:
20110189698 - Protein biomarkers and methods for diagnosing kawasaki disease: A method, kit and device for diagnosing Kawasaki Disease are provided. The invention provides detecting an expression level of at least two Kawasaki Disease diagnostic biomarkers in a biological sample from a patient with a capture agent and diagnosing the patient as having Kawasaki Disease when the expression levels of... Agent: The Regents Of The University Of California
20110189697 - Recombinant cells and plants for synthesis of very long chains fatty acid (vlcfa): The present disclosure is relative to a method for the production of Very-Long-Chain Fatty Acids (VLCFA) into a plant cell, including culturing a recombinant plant cell in an appropriate medium, wherein said plant cell is transformed with an heterologous gene encoding for an hydroxyacyl-CoA dehydratase. The disclosure is also relative... Agent: Rothamsted Research Ltd.
20110189699 - Autoantibodies for protein antigens as markers for cancer of gingivo-buccal complex: The present invention relates to identification of a set of proteins, which elicit an autoantibody response in patients with cancer of gingivo-buccal complex. Systematic comparisons of serum samples from clinically normal individuals and from patients with cancer of gingivo-buccal complex has revealed significant differences in the presence of autoantibodies in... Agent:
20110189701 - Centrifugal micro-fluidic device and method for detecting analytes from liquid specimen: A centrifugal micro-fluidic device detecting analytes in a liquid specimen and a method of detection of analytes from a liquid specimen using the micro-fluidic device are provided. Reaction efficiency is increased using a repetitive flow of the liquid specimen induced by an alternating combination of capillary force and centrifugal force,... Agent: Samsung Electronics Co., Ltd.
20110189700 - Cyr61 as a biomarker for diagnosis and prognosis of cancers of epithelial origin: Urinary Cyr61 protein levels are up regulated in patients that have cancers of epithelial origin, i.e. breast cancer and ovarian cancer. Accordingly, the present invention is directed to methods for prognostic evaluation, and diagnosis of cancers of epithelial origin. Further, the amount of Cyr61 protein detected in a urine sample... Agent:
20110189707 - Goodpasture antigen binding protein and its detection: The present invention provides native Goodpasture antigen binding protein isoforms, monoclonal antibodies directed against such proteins, and methods for their use.... Agent: Fibrostatin, Sociedad Limitada
20110189705 - Immunoassay: The invention provides a highly sensitive immunoassay for detection of a biological species. The immunoassay comprises exposing an electrode to an analyte liquid putatively containing the biological species so as to couple the biological species, if present in the analyte liquid, to a binding antibody on the electrode. The electrode... Agent:
20110189704 - Non-specific reaction inhibitor: Disclosed is a non-specific reaction inhibitor for use in an immunological measurement, comprising a complex of an antibody or a fragment of the antibody capable of specifically binding to a non-specific reaction factor, and a polymer. The non-specific reaction inhibitor can inhibit a non-specific reaction which may interfere with the... Agent: Mitsubishi Chemical Medience Corporation
20110189706 - Process for the measurement of the potency of glatiramer acetate: The subject invention provides a process for measuring the relative potency of a test batch of glatiramer acetate. In addition, the subject invention provides a process for preparing a batch of glatiramer acetate as acceptable for pharmaceutical use.... Agent: Teva Pharmaceutical Industries, Ltd.
20110189708 - Method for evaluating specific incorporation of d-glucose into cells: An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically... Agent: National University Corporation Tokyo University Of Agriculture And Technology
20110189709 - Method for detecting hepatic injury due to antithyroid drug: The present invention relates a detecting method of distinguishing a temporary liver function test abnormalities by a thyrotoxicosis from a drug-induced hepatic injury by an antithyroid drug using a blood test and the likes, which is performed in a simple manner and with specificity. In the course of treating Graves'... Agent: Yamasa Corporation
20110189711 - Paad domain-containing polypeptides, encoding nucleic acids, and methods of use: The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and ARED domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that... Agent: Sanford-burnham Medical Research Institute
20110189710 - Treatment of pompe disease with specific pharmacological chaperones and monitoring treatment using surrogate markers: Provided is a method of monitoring the treatment of Pompe disease with specific pharmacological chaperones using systemic and/or cellular surrogate markers.... Agent: Amicus Therapeutics, Inc.
20110189712 - Methods for assaying percentage of glycated hemoglobin: The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular... Agent: General Atomics
20110189720 - Automated biological sample collection system and method: An automated biological sample collection system and method are disclosed. The system comprises an incubator, an applicator and a sampler. The incubator is configured to control the environment of a plurality of eggs, the applicator is configured to deliver exogenous material to the plurality of eggs and at least one... Agent:
20110189723 - Cell detection method, and microarray chip for use in the method: Disclosed is a detection method for detecting a specific cell in a sample containing multiple cells including the specific cell. Specifically disclosed is a detection method for detecting a specific cell in a sample containing multiple cells including the specific cell, which comprises the following steps (1) and (2): (1)... Agent: National Institute Of Advanced Industrial Science And Technology
20110189713 - Device for the preparation and fractioned dispensing of fluid samples, dispensing system including such device and related method: The present invention relates to a device, to a system, and to a method for the preparation and fractioned dispensing of samples of a fluid. The device of the invention comprises a body having formed therein guide means suitable for receiving a sample-taker member and for guiding it in translation... Agent:
20110189721 - Interactive transparent individual cells biochip processor: An Interactive Transparent Individual Cells Biochip Processor (ITICBP) device is described, which is useful for assessing a single, individual living cell at identifiable location or assessing group of cells each at identifiable location.... Agent: Bar-llan University
20110189715 - Measuring multi-analyte samples using an in-line flow cell: Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can... Agent:
20110189716 - Method for analyzing collagenous tissues for the detection and diagnosis of bone disease: Methods and systems for diagnosing a bone disease related to collagen pathology in a subject are provided. These include providing a bone sample from the subject and determining a quantitative collagen morphology value of the bone sample. A reference value is provided from a non-affected control subject where the reference... Agent: The Regents Of The University Of Michigan
20110189722 - Method for preparing cell standard: The present invention relates to a method for preparing cell samples for histological examination and, more particularly, a method for preparing a cell sample as a standard, or control, for use in the fields of cytology and histology.... Agent: Leica Biosystems Newcastle Limited
20110189719 - Methods of generating patterned soft substrates and uses thereof: The present invention provides methods of generating and devices of patterned soft substrates, on which cells may be seeded, as well as methods of using these substrates. Devices containing these patterned soft substrates are also provided.... Agent: President And Fellows Of Harvard College
20110189717 - Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway: The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.... Agent: Massachusetts Institute Of Technology
20110189725 - Microbiological analysis assembly and method: The method comprises the steps of selecting such an assembly, of engaging the said unit (1) on the said cassette (80) until the intermediate stop (26) of the said unit (1) comes into contact with the intermediate stop (100) of the said cassette (80), and the step of moving clear... Agent: Millipore Corporation
20110189714 - Microfluidic cell sorter and method: A biological particle sorting device and method of its use. The device includes structure arranged to urge biological particles into substantially single file travel through an interrogation zone. Operable alignment structure nonexclusively include sheathed fluid flow, capillary tubes, an orifice, and fluid microchannels. One or more detector, selected from a... Agent:
20110189724 - System for testing biological and chemical agents using two or more cartridges simulating systems in the body: The present invention relates to joining two or more cartridges containing cell or tissue cultures from different organs found in the human body in fluid connection. It includes a vitro method and system for testing chemicals and agents as they pass through organs other than the brain or combinations of... Agent: Cleveland Medical Devices Inc.
20110189718 - Systems and methods for segregating mixed material streams: The invention relates to methods and systems of detecting useful material in a mixed solid, liquid and/or gaseous material stream. The methods include defining a value range requirement for at least one parameter of interest of useful material to be selected from the material stream, passing the material stream through... Agent:
20110189726 - Biosynthesis of derivatives of monacolin j: The invention relates to a process for obtaining monacolin J derivatives (I), wherein R1 is COR2, wherein R2 is selected from C1-C15 alkyl, C3-C15 cycloalkyl, C2-C15 alkenyl, C2-C15 alkynyl, aryl and heterocyclyl; which comprises producing monacolin J by fermentation from a monacolin J-producing microorganism; and acylating the hydroxyl group present... Agent: Neuron Biopharma, S.a.
20110189727 - Method for modifying non-starch carbohydrate material using peroxidase enzyme: A method for the modification of a material comprising a non-starch carbohydrate, which method comprises contacting said material comprising a non-starch carbohydrate with a polypeptide which has peroxidase activity and which is: a. a polypeptide comprising an amino acid sequence having at least 55% homology with an amino acid sequence... Agent:
20110189728 - Pentose sugar fermenting cell: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least about 70% sequence identity to the amino acid sequence set out in SEQ ID NO: 3 and wherein the nucleotide sequence is heterologous... Agent:
20110189729 - Novel recombination sequences: The present invention relates to novel nucleotide sequences, which are variants of att recombination sequences, involved in sequence-specific recombination of DNA in eukaryotic cells, whereby sequence specific recombination is performed by a bacteriophage lambda integrase Int. Such novel att recombination sequences being e.g. attP.b, attP.a, attL.a, attR.a and attR.b. The... Agent: Boehringer Ingelheim Pharma Gmbh & Co. Kg
20110189731 - Polynucleotides encoding recombinant lubricin molecules and uses thereof: Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e.g., synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.... Agent: Wyeth LLC
20110189730 - Viral nucleocapsid protein as a multifunctional translation initiation factor and increased protein and polypeptide production using same: The present invention is directed to a system to significantly increase the expression of genes of interest, and in particular proteins and polypeptide products. Expression of hantavirus nucleocapsid protein (N) by itself results in augmented translational expression of diverse genes. The mechanism of this augmentation relies on the ability of... Agent:
20110189733 - Low cell density fermentation process for the production of heterologous recombinant proteins in microorganisms: A low cell density fermentation process for the production of heterologous proteins in microorganisms. The cell culture obtained by cultivating host microorganisms transformed with a vector carrying genetic material for the said proteins and an inducible promoter under batch fermentation conditions is fed with a feed medium after an OD600... Agent: Usv Limited
20110189732 - Process for the fermentative production of erythropoietin: The present invention relates to a process for the fermentative continuous production of erythropoietin, where eukaryotic erythropoietin-producing cells are cultured in a perfusion reactor while retaining the cells, the glucose concentration in the culture supernatant being adjusted via the perfusion rate and the cell number via the cell retention rate... Agent: Evonik Degussa Gmbh
20110189734 - Novel methods and cell lines: This invention relates to fermentation processes for producing antibodies and other antigen binding compounds. Specifically, the present invention provides methods for increasing the specific productivity of an antibody produced in cell culture, increasing cell growth and increasing viability of cells in cell culture. Also provided are, expression stable, viable cell... Agent:
20110189735 - Superagonistic anti-cd28 antibodies: i
20110189736 - Novel hot start nucleic acid amplification: Methods and compositions for performing nucleic acid duplication and amplification reactions are provided. A single-stranded nucleic acid binding protein is selected and provided in the reaction mixture which is assembled at a low, nonstringent temperature to include all of the necessary reagents for successful nucleic acid duplication or amplification reactions.... Agent: Affymetrix, Inc.
20110189737 - Methods for producing hyaluronan in a recombinant host cell: The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a Bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein the Bacillus host cell comprises a nucleic acid construct comprising a hyaluronan synthase encoding sequence operably linked to a promoter sequence foreign... Agent: Novozymes, Inc.
20110189738 - Process for producing glutamate derivatives: The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.... Agent: Ajinomoto Co., Inc.
20110189739 - Escherichia coli strain with enhanced l-threonine productivity and method of producing l-threonine using the same: An L-threonine-producing Escherichia coli in which a promoter of a phosphoenolpyruvate carboxylase (ppc) gene on the chromosome is substituted with a promoter of a cysteine synthase (cysK) gene and a method of producing L-threonine by using the same are disclosed. The recombinant Escherichia coli may produce L-threonine in a high... Agent: Cj Cheiljedang Corp.
20110189740 - Catalyst for the decomposition of lignin, method for the preparation of alcohols and organic acids, method for the preparation of lignin-decomposition products, catalyst for the decomposition of aromatic hydrocarbons, method for releasing hydrogen ions, a: Herein provided are a lignin-decomposition catalyst and an aromatic hydrocarbon-decomposition catalyst, which contain a porphyrin. Alcohols and organic acids can be isolated or separated from lignin by adding a solution containing an alkaline compound to lignin, optionally acting a lignin-decomposition catalyst on the resulting lignin-alkaline compound-containing solution and optionally irradiating,... Agent:
20110189741 - Process and apparatus for extracting biodiesel from algae: The present invention relates to a system for cultivation of algae, extraction of lipids and transesterification of the lipids to obtain biodiesel. The system comprises three sections, that is to say cultivation, extraction and storage and reaction. In the lipid extraction area there is an ultrasonic reactor wherein the external... Agent:
20110189742 - Method for the production of free carboxylic acids: where R1, R2 and R3, independently of one another, are identical or different, branched or unbranched, optionally substituted hydrocarbon radicals or H; B) for cases where the added amine A) is water-soluble, addition of a water-insoluble amine of formula (I), where, in A) or B), a multiphase system is obtained... Agent: Evonik Roehm Gmbh
20110189743 - Microbial systems for producing commodity chemicals: Provided are improved recombinant microorganisms, and methods of use thereof, for metabolizing biomolecules and producing commodity chemicals such as ethanol therefrom, and genetic constructs to achieve that end.... Agent: Bio Architecture Lab, Inc.
20110189744 - Construction of protrophic/celluloytic yeast strains expressing tethered and secreted cellulases: The present invention is directed to the construction of prototrophic, cellulo lytic strains of Saccharomyces cerevisiae with tethered and secreted cellulases and selection-based improvement of growth on cellulose by these strains. In some embodiments, host cells of the invention are able to produce ethanol using crystalline cellulose as a sole... Agent:
20110189745 - Production of biodiesel, cellulosic sugars, and peptides from the simultaneous esterification and alcoholysis/hydrolysis of materials with oil-containing substituents including phospholipids and cellulosic and peptidic content: The present invention relates to a method for producing fatty acid alkyl esters as well as cellulosic simplified sugars, shortened protein polymers, amino acids, or combination thereof resulting from the simultaneous esterification and hydrolysis, alcoholysis, or both of algae and other oil containing materials containing phospholipids, free fatty acids (FFA),... Agent: Inventure Chemical, Inc.
20110189746 - Utilizing waste tail gas from a separation unit biogas upgrade systems as beneficial fuel: The invention relates to a method for utilizing low-quality tail gas derived from a pressure swing adsorption system or membrane system, which is used to upgrade biogas, as a beneficial fuel for the facility and/or digester boiler.... Agent: Guild Associates, Inc.
20110189747 - Process for producing silage for biogas production: The invention provides the use of a lactic acid bacterium and optionally a Bacillus for producing a silage which may be advantageously used for the production of biogas. The invention also provides the use of a lactic acid bacterium and optionally a Bacillus for producing biogas.... Agent: Chr-hansen A/s
20110189748 - Ultrasound enhanced growth of microorganisms.: A method of increasing the rate of growth, useful product production, or protein expression of a microorganism includes the step of exposing the microorganism to ultrasound having a frequency greater than about 1 MHz.... Agent: Intelligentnano Inc.
20110189750 - Carbonic anhydrase enhanced reaction methods and formulations: Disclosed is a formulation for the absorption of CO2, which comprises water, at least one CO2 absorption compound and a carbonic anhydrase as an activator to enhance the absorption capacity of the CO2 absorption compound. The invention also concerns the use of carbonic anhydrase, in a CO2 absorption solution to... Agent: Co2 Solution Inc.
20110189749 - Trapping, recycling, and other techniques involving catalysts: Trapping, recycling, and other techniques involving catalysts are provided by this invention. The present invention provides for the retention of catalysts and other immobilized entities within a reaction region. In one aspect, the invention promotes such retention by incorporating support material regions including relatively little (or, in some cases, substantially... Agent: Massachusetts Institute Of Technology
20110189752 - Complex: A complex comprising at least one target protein and at least one binding molecule having a binding affinity for said target protein, wherein said molecule having a binding affinity is covalently or non-covalently bound to at least one water-soluble polymer... Agent: Octapharma Ag
20110189754 - Fusion protein comprising an e. coli chaperone protein and a human chaperone protein: The invention discloses the cloning, expression and uses of a chimeric fusion protein with superior chaperone and folding activities compared to the wild type chaperones. This invention relates to a chimeric fusion protein encoded by a recombinant DNA molecule containing nucleotide sequences coding for a polypeptide binding segment of a... Agent:
20110189753 - Intracellular production of a nuclease: Methods and compositions are provided that relate to obtaining a recombinant DNA and RNA cleaving nuclease. This involves the over-expression of a fusion protein between maltose-binding protein and a truncated nuclease in a soluble form in the cytoplasm of a host cell from which it can be readily extracted.... Agent: New England Biolabs, Inc.
20110189751 - Methods and compositions comprising heat shock proteins: Compositions, and uses thereof, which are beneficial for eukaryotic cells in culture, and methods for their use in promoting cell growth, viability and recombinant protein expression. The methods disclosed in the present application are useful, for example, for improving cell viability and in accelerating the rate of cell growth of... Agent: Ventria Bioscience
20110189755 - Method for the production of an additive for the enzymatic decomposition of mycotoxins, additive, and use thereof: In a method for producing an additive for the enzymatic degradation of mycotoxins, in particular fumonisins, it is provided that at least one nucleic acid sequence of genes corresponding to sequences ID Nos. 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22 and 24 is provided, the... Agent:
20110189756 - Method and composition for crystallizing g protein-coupled receptors: Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and... Agent:
20110189757 - Transfection vector: The present invention relates to a novel secretory signal, a novel plasmid containing the secretory signal, a transformed anaerobic bacterium transformed with said plasmid, a gene transfer carrier consisting of said anaerobic bacterium, and a pharmaceutical composition containing said carrier.... Agent: Anaeropharma Science, Inc.
20110189758 - Transfection vector: The present invention relates to a novel secretory signal, a novel plasmid containing the secretory signal, a transformed anaerobic bacterium transformed with said plasmid, a gene transfer carrier consisting of said anaerobic bacterium, and a pharmaceutical composition containing said carrier.... Agent: Anaeropharma Science, Inc.
20110189759 - Method and device for the digetsion of biological cells: The invention relates to a method and a device for the digestion of biological cells. Digestion of cells is understood as breaking up cells so that hereditary information can be removed. Using the present invention, nucleic acids are to be able to be removed from cells in particular. The nucleic... Agent:
20110189760 - Method for producing lipids: The present invention relates to a method for efficiently extracting and producing lipid components from crustaceans. A method for producing lipids, characterized by obtaining a squeezed liquid by squeezing a whole crustacean or a part thereof, heating the squeezed liquid to a temperature at which proteins contained in the squeezed... Agent: Nippon Suisan Kaisha, Ltd.
20110189761 - Method for producing cell culture scaffold: A method for producing a cell culture scaffold material, comprising: providing a substrate; foaming a layer comprising a material having a plurality of nanoparticles dispersed in a matrix on the substrate; and selectively removing the nanoparticles from the layer comprising a material having a plurality of nanoparticles dispersed in a... Agent: Island Giant Development LLP
20110189762 - Electrochemical sensor and method for manufacturing: The present disclosure relates to a sensor including an elongated member including at least a portion that is electrically conductive. The elongated member includes a sensing layer adapted to react with a material desired to be sensed. An insulating layer surrounds the elongated member. The insulating layer defines at least... Agent: Pepex Biomedical LLC
20110189763 - Kit and method for evaluating detection properties in amplification reactions: The invention relates to a kit comprising, (a) a first group of containers, comprising two or more containers with human genomic DNA, wherein the human genomic DNA in each of the two or more containers is of different human origin and the amount of DNA in the container is defined,... Agent: Biotype Gmbh
20110189764 - Single use device incorporating a container and scaffold: The present invention relates to a single use device, alternatively called an assembly, that primarily comprises a single use container or bioreactor that incorporates a scaffold and is used in the growth, processing and/or preservation of cells, sterile fluid or related biopharmaceutical product and that may be at least partially... Agent:
20110189765 - Incubator: An incubator including a cultivating chamber for cultivating cultures, a water supply control unit for supplying water into the cultivating chamber through a water supply passage and adjusting the humidity of the inside of the cultivating chamber, and a filter provided in the water supply passage.... Agent: Sanyo Electric Co., Ltd.
20110189766 - Micrornas and uses thereof: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of... Agent:
20110189768 - Mesenchymal stem cells expressing tnf-alpha receptors: Mesenchymal stem cells which express TNF-α receptor Type I in an amount of at least 13 pg/106 cells. Such mesenchymal stem cells inhibit the proliferation of lymphocytes and may be employed, in particular, in the treatment of graft-versus-host disease.... Agent:
20110189767 - Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures prepared using same: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.... Agent: Technion Research & Development Foundation Ltd.
20110189770 - Endosome-disrupting compositions and conjugates: The present invention is directed to an endosome-disrupting conjugate, and methods of delivery of said conjugate to cells. The conjugates of the invention comprise a payload and an endosome-disrupting component of which the latter comprises a plurality of moieties that react under acidic conditions, e.g., within an endosome, to release... Agent: The Charles Stark Draper Laboratory, Inc.
20110189769 - Methods and compositions for manipulating the guided navigation of endothelial tubes during angiogenesis: Methods and compositions for manipulating the directed navigation of physiological tracking tubular structures are provided. A novel cell-bound receptor, roundabout-4 (Robo-4), is described. The Robo-4 receptor shows sequence and structural similarity to members of the roundabout family of receptors. Also, the Robo-4 receptor binds Slit ligand, a known receptor of... Agent: University Of Utah Research Foundation
20110189771 - Novel imino sugar derivatives demonstrate potent antiviral activity and reducted toxicity: Imino sugars, such as deoxynojirimycin (DNJ), are glucose analogues that selectively inhibit cellular α-glucosidase I and II (enzymes that process N-linked glycans in glycoprotein) and exhibit broad spectrum antiviral activities against many enveloped viruses. Previously we have reported a novel DNJ derivative, OSL-95II, with antiviral activity and reduced cytotoxicity. In... Agent: Institute For Hepatitis And Virus Research
20110189772 - Bioreactor with dual compartment: The invention relates to a method for using a dual-compartment bioreactor that comprises a flexible pouch (1) with two compartments (2, 3) separated by a filter (4), as well as at least one inlet opening (5) in communication with one of the compartments (2) and at least one outlet opening... Agent:
20110189773 - Silk fibroin fiber bundles for matrices in tissue engineering: The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that... Agent: Allergan, Inc.
20110189774 - Plant centromere compositions: The present invention provides for the nucleic acid sequences of plant centromeres. This will permit construction of stably inherited recombinant DNA constructs and minichromosomes which can serve as vectors for the construction of transgenic plant and animal cells.... Agent: Chromatin, Inc.
20110189775 - Targeted genomic alteration: Disclosed herein are methods and compositions for targeted integration and/or targeted excision of one or more sequences into a cell, for example, for expression of one or more polypeptides of interest.... Agent: Sangamo Biosciences, Inc.
20110189776 - Prokaryotic rnai-like system and methods of use: Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5′ region and a 3′ region. The 5′ region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3′... Agent: University Of Georgia Research Foundation, Inc.Previous industry: Education and demonstration
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