|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology July category listing 07/11Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 07/28/2011 > patent applications in patent subcategories.
20110183310 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Lifeline Scientific, Inc.
20110183311 - Dry platelet preparations for use in diagnostics: The present invention provides compositions comprising freeze-dried platelets, microparticles, or both for use as a diagnostic for blood coagulation function. The invention also provides methods of diagnosing or monitoring blood coagulation function, including diagnosing or monitoring blood coagulation diseases and disorders. Kits for performing the methods of the invention are... Agent:
20110183312 - Microfluidic chip for accurately controllable cell culture: A device is disclosed for culturing cells in at least one cell culture well. The device includes one or more interconnecting layers having a pattern therein, the pattern including at least one microfluidic channel, at least one cell culture well having an opening at one end and a side wall,... Agent: Peking University
20110183314 - Bacteriophage-based microorganism diagnostic assay using speed or acceleration of bacteriophage reproduction: A method of determining the presence or absence of a target microorganism in a sample to be tested, the method comprising: combining with the sample an amount of bacteriophage capable of infecting the target microorganism to create a bacteriophage-exposed sample; and measuring the time rate of change of the amount... Agent: Microphage Incorporated
20110183315 - Detection of west nile virus nucleic acids in the viral 3' non-coding region: Methods for detecting flavivirus nucleic acids. Particularly described are methods for detecting West Nile virus nucleic acids in the 3′ non-coding region.... Agent: Gen-probe Incorporated
20110183317 - Determining the sensitivity of a cell to a drug: The present invention provides an in vitro method for determining the resistance or sensitivity of a cell line or patient sample to a deoxyribonucleoside kinase-dependent drug, wherein the method comprises the steps of: (i) treating a patient sample or cell line, or a portion thereof, with a deoxyribonucleoside kinase-dependent drug;... Agent: University Of The West Of England
20110183313 - Genome wide visual identification of human co-factors of hiv-1 infection: The present invention relates to the identification of human host factors involved in the early stage of HIV infection. Furthermore, it relates to the use of the identified genes for the elucidation of the mechanism of HIV-infection, as drug targets, and for identifying a compound useful in the treatment of... Agent:
20110183316 - Methods for detecting organisms and enzymatic reactions using raman spectroscopy: The present disclosure provides systems for the rapid and sensitive detection of organisms and molecules in samples. Reactants that produce Raman-active products are used in combination with Raman light scattering. The present disclosure can also be used to measure enzyme-kinetics.... Agent: Sword Diagnostics, Inc.
20110183320 - Classification of nucleic acid templates: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary... Agent: Pacific Biosciences Of California, Inc.
20110183319 - Compositions and methods for therapeutic delivery with microorganisms: Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that include modified microorganisms including at least one genetic element encoding at least one therapeutic agent or environmental treatment agent.... Agent: Searete LLC, A Limited Liability Corporation Of The State Of Delaware
20110183325 - Method and apparatus for disrupting cells and purifying nucleic acid using a single chip: Provided herein is a method and apparatus for disrupting cells and purifying nucleic acids in a single chip. The method comprises irradiating a chip with a laser beam, wherein the chip comprises a solid support on which a cell lysis enhancing metal oxide layer, and a cell binding metal oxide... Agent: Samsung Electronics Co., Ltd.
20110183318 - Method for screening of substance effective on disease using gpr120 and phospholipase: The present invention provides a screening method for determining whether a substance of interest is a substance which alters GPR120 mediated cell stimulating activities, comprising using a substance of interest, a biomembrane containing GPR120, or cells containing said biomembrane, and phospholipase or salts thereof. According to a screening method of... Agent: Eisai R&d Management Co., Ltd
20110183321 - Method of determining the nucleotide sequence of oligonucleotides and dna molecules: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown... Agent: Arizona Board Of Regents
20110183322 - Method of determining the nucleotide sequence of oligonucleotides and dna molecules: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown... Agent: Arizona Board Of Regents
20110183323 - Method of determining the nucleotide sequence of oligonucleotides and dna molecules: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown... Agent: Arizona Board Of Regents
20110183324 - Tumor suppressor gene p33ing2: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.... Agent: The Govt. Of The U.s.a. As Represented By The Secretary Of The Dept. Of Health & Human Services
20110183330 - Analysis for nucleic acids by digital pcr: The present invention provides a method for analyzing nucleic acids for their lengths and relative abundance in a sample, based on digital amplification of individual template molecules. This invention has many applications, including those in noninvasive prenatal diagnosis, transplantation monitoring, and the detection and monitoring of cancers and virus-associated diseases.... Agent: The Chinese University Of Hong Kong
20110183328 - Detecting neoplasm: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.... Agent: Mayo Foundation For Medical Education And Research
20110183326 - Free circulating dna bio-markers and their applications: This invention relates generally to methods for detecting cell damage as a consequence of pathophysiological or traumatic insults such as in a nuclear accident, bioterror attack, tumorigenesis, infections or in individuals with cardiovascular disease.... Agent: Diacarta LLC
20110183327 - Labelled nucleotides: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.... Agent:
20110183334 - Method for detection of cancer based on spatial genome organization: The invention provides methods of detecting abnormal cells in a sample using the radial position of one or more genes within the nucleus of a cell, as well as a kit for detecting abnormal cells using such methods. The invention also provides methods of identifying gene markers for abnormal cells... Agent: The United States Of America As Represented By The Secretary, Dept Of Health And Human Services
20110183333 - Method for prediction of the progression risk of tumors: The present invention concerns a method for predicting the potential for aggressive growth and/or the risk to progress to high grade cancer for tumors in cell based detection procedures. In one aspect the invention concerns the detection of overexpression of cyclin-dependent kinase inhibitor gene products as a tool for predicting... Agent:
20110183332 - Method for recovering nucleic acid from stool sample, nucleic acid analysis method and stool sample processing apparatus: The present invention relates to the a nucleic acid analysis method that uses nucleic acid recovered according to the nucleic acid recovery method, and a stool sample processing apparatus used in that method, wherein the method has steps of: (A) eluting nucleic acid amplification reaction inhibitory substances by preparing a... Agent: Olympus Corporation
20110183335 - Methods and compositions for perioperative genomic profiling: The present invention relates to methods for perioperative genomic screening of subjects, in particular to perioperative screening for markers indicative of responses to anesthesia and other perioperative or operative treatments and procedures. The present invention also provides compositions for use in screening methods. The methods and compositions of the present... Agent:
20110183329 - Protein phosphatase-1 inhibitor-1 polymorphism and methods of use: A method for diagnosing the presence of a G147D polymorphism of human phosphatase-1 inhibitor-1 protein is provided, wherein the method involves determining the presence of the polymorphism in a biological sample from a human subject by means which detect the presence of the polymorphism, wherein the presence of the polymorphism... Agent: The University Of Cincinnati
20110183331 - Rna in situ hybridization: m
20110183344 - Compositions for use in identification of clostridium difficile: The present invention relates generally to identification of strains of Clostridium difficile and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent:
20110183343 - Compositions for use in identification of members of the bacterial class alphaproteobacter: The present invention relates generally to identification of members of the bacterial class Alphaproteobacter and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent:
20110183346 - Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria: The present invention relates generally to the detection and identification of Neisseria, Chlamydia, and/or Chlamydophila bacterial bioagents, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent: Ibis Biosciences, Inc.
20110183345 - Compositions for use in identification of streptococcus pneumoniae: The present invention relates generally to the identification of Streptococcus pneumoniae, such as antibiotic resistant Streptococcus pneumoniae, and provides methods, compositions, kits and systems useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent: Ibis Biosciences, Inc.
20110183337 - Method and kit for use in the differentiation of ibd and ibs and further distinction between disease types of ibd: A quantification of the expression levels of a number of specific genes and their corresponding proteins can be utilized in accurately determining, using samples from faeces or blood, whether the patient is suffering from irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD), and in a follow up analysis using... Agent:
20110183336 - Method to predict responsiveness of breast cancer to polyamine-type chemotherapy: Methods of-identifying a basal or luminal phenotype of a cell, comprising detecting expression of one or more of a set of predictive biomarker genes or proteins that identify the cell as having a basal or luminal cancer subtype and compositions for treating identified basal or luminal cancers.... Agent: The Regents Of The University Of California
20110183342 - Methods for detecting a mycobacterium tuberculosis infection: Methods for detecting an infection with Mycobacterium tuberculosis (Mtb) in a subject are disclosed, wherein the subject is a child, a subject with a latent Mycobacterium tuberculosis infection. Method are also disclose for detecting an extra-pulmonary Mycobacterium tuberculosis infection in a subject. The methods include detecting the presence of CD8+... Agent:
20110183340 - Phenotype-genotype relationship in age-related macular degeneration: Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs 10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may... Agent: Duke University
20110183339 - Probes for detecting the presence of trichomonas vaginalis in a sample: Oligonucleotides useful for determining the presence of Trichomonas vaginalis in a test sample.... Agent: Gen-probe Incorporation
20110183338 - Two stage enrichment of cell-free fetal dna in maternal plasma: The present invention provides methods for enriching fetal nucleic acid in a biological sample from a maternal host. Also provided are methods for detecting the presence or absence of markers in fetal, tumor, or neoplastic nucleic acid. The methods can include treating the biological sample with DNase and, optionally, performing... Agent: Novartis Vaccines And Diagnostics, Inc.
20110183341 - Use of 14-3-3-proteins in treatment and prevention of neurodegeneration: The present disclosure is directed to methods for treatment and prevention of disease states characterized by a decreased 14-3-3 polypeptide expression or activity. In one embodiment, the present disclosure provides methods for the treatment and/or prevention of Parkinson's disease, neurodegeneration and/or diseases characterized, at least in part, by neurodegeneration, by... Agent: The Uab Research Foundation
20110183347 - Compositions and methods for therapeutic delivery with microorganisms: Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that include modified microorganisms including at least one genetic element encoding at least one therapeutic agent or environmental treatment agent.... Agent: Searete LLC, A Limited Liability Corporation Of State Of Delaware
20110183348 - Compositions and methods for therapeutic delivery with microorganisms: Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that include modified microorganisms including at least one genetic element encoding at least one therapeutic agent or environmental treatment agent.... Agent: Searete LLC, A Limited Liability Corporation Of The State Of Delaware
20110183349 - Biomarkers for iga nephropathy and applications thereof: The present invention provides a method for diagnosis or prognosis of IgA nephropathy in a subject based on detection of the expression level of one or more biomarker genes selected from the group consisting of thymosin β4 (Tmsb4), serine or cysteine proteinase inhibitor clade E member 2 (Serpine2), secreted phosphoprotein... Agent: National Defense Medical Center
20110183350 - Method for selecting secondary neurosphere derived from differentiated cell-derived pluripotent stem cell, clone selected by the method and use of the clone: In order to provide a therapeutic agent for nerve injury which contains iPS-derived neural stem cells and has low or no risk of side effects, as well as a method for treating a nerve injury using the iPS cells, by efficiently establishing in vivo the iPS-derived neural stem having low... Agent: Kyoto University
20110183353 - Composition and method for diagnosing fungal disease: Methods of diagnosing a fungal infection using anti-glycan antibodies alone or in combination with other anti-fungal diagnostic tests are described. Laminaribioside and chitobioside are used as antigens to detect human antibodies.... Agent:
20110183351 - Compositions and methods for therapeutic delivery with microorganisms: Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that include modified microorganisms including at least one genetic element encoding at least one therapeutic agent or environmental treatment agent.... Agent:
20110183352 - Configurable diagnostic systems and methods for performing assays: A method and system for configuring an analyzer is disclosed. The analyzer receives a strip identifier from a strip or a vial identifier from a vial. The parameter module in the analyzer determines the parameters corresponding to the received strip identifier or the vial identifier. The parameter module then configures... Agent:
20110183354 - Human fc gamma receptor iii: The present invention relates to the field of human immunoglobulin receptors, specifically the glycostructure of a human Fc gamma receptor IIIa recombinantly expressed in human embryonic kidney cells and Chinese hamster ovary cells.... Agent:
20110183356 - Method to identify patients at risk for lung transplant rejection: Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one method pulmonary disease and disorders such as Idiopathic Pulmonary Fibrosis (IPF) are diagnosed by analyzing fluid or tissue samples obtained... Agent: Indiana University Research And Technology Corporation
20110183355 - Polymer particle containing fluorescent molecule and method for producing the same: Polymer particles are provided which contain fluorescent molecules with high presence ratio in a polymer layer thereof and a method for preparing thereof. Polymer particles are swelled in a non-aqueous solution excluding exclusively water preferably promotes selling of the polymer layer and transfer of the fluorescent molecules to the polymer... Agent: Tokyo Institute Of Technology
20110183359 - Methods for detecting modulators of cytokine receptor zalpha11: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can... Agent: Zymogenetics, Inc.
20110183360 - Antibodies to clostridium difficile spores and uses thereof: The present invention provides antibodies that bind to the endospore of the bacterium Clostridium difficile, methods of making such antibodies, and methods of using such antibodies, including methods of detecting C. difficile endospores.... Agent:
20110183357 - Device and methods for liquid crystal-based bioagent detection: The present invention provides liquid crystal-based devices and methods for bioagent detection. In certain aspects, the present invention is directed to devices and methods utilizing liquid crystals and membranes containing polymerized targets that can report the presence of bioagents including, but not limited to, enzymes, antibodies, and toxins.... Agent: Wisconsin Alumni Research Foundation
20110183361 - Nonseparation assay methods: Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support as is a member of a specific binding pair for capturing an analyte from a sample. An activator compound that activates the chemiluminescent... Agent: Beckman Coulter, Inc.
20110183358 - Methods and compositions for derepression of iap-inhibited caspase: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.... Agent: Torrey Pines Institute For Molecular Studies
20110183364 - Analytical method for the detection of latent hepatitis c, use thereof and corresponding diagnosis kit: The invention relates to an improved analytical method for the detection of latent hepatitis C, to the use thereof and to the corresponding diagnosis kit. The analytical method is based on the immunoassay technique and the most suitable operating conditions for detecting latent hepatitis C have been determined. The invention... Agent: Fundacion Para El Estudio De Las Hepatitis Virales
20110183363 - Assays for detecting antibodies specific to therapeutic anti-ige antibodies and their use in anaphylaxis: The invention provides methods and reagents useful for detecting anti-drug antibodies of IgE isotype to therapeutic anti-IgE antibodies, and methods for assessing risk of anaphylaxis to administration of a therapeutic anti-IgE antibody.... Agent:
20110183362 - Compositions and methods for measuring levels of bioactive human hepcidin: The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive... Agent: Intrinsic Lifesciences LLC
20110183366 - Methods for achieving a protective ace2 expression level to treat kidney disease and hypertension: The present invention provides a method for enhancing expression of angiotensin converting enzyme ACE2 in the vasculature of a mammal, particularly in the renal vasculature and podocytes. The method comprises administering to a mammal in need of such enhancement (e.g., a mammal suffering from, or at risk of developing renal... Agent:
20110183365 - Thrombin generation determination method: A method for measuring a generation of thrombin in a sample of whole blood as a function of time includes adding to a sample of whole blood a fluorogenic substrate and a thrombin activator to form an activated sample. A conversion product is permitted to form in the activated sample.... Agent: Adventist Health System/sunbelt, Inc.
20110183367 - Device and method for non-invasive measurement of the individual metabolic rate of a substantially spherical metabolizing particle: The present invention relates to methods and devices for non-invasive and non-disturbing measurements of metabolizing rates of substantially spherical metabolizing particles, such as an embryo, and to a method and device for controlling oxygen partial pressure at the level of the embryo. Furthermore, the invention relates to a method for... Agent:
20110183368 - Method and apparatus for using light emitting diodes in a greenhouse setting: There is provided a modular LED system comprising a frame (1) having a plurality of light emitting diodes (LEDs) (8) of at least two different colors for generating light within a color spectrum, said LEDs (8) being mounted, preferably clickable, on or adjacent to a, preferably heat conductive, plate equipped... Agent: Fionia Lighting Aps
20110183369 - Plant infesting systems and methods: The present disclosure provides systems and methods for infesting the roots of a plant with larval insects. In various embodiments, an exemplary method includes injecting an egg solution into a root zone of the plant, wherein the root zone is disposed within a planting media of the plant.... Agent: Monsanto Technology LLC
20110183370 - Optical imaging for identifying cells labeled with fluorescent nanoparticles: An optical detection system for identifying target bacterial cells in a food sample, comprising a first fluorescent nanoparticle dye labeling specifically the target cells. A second fluorescent dye reacts non-specifically with all bacterial cells. An imaging unit optically excites the fluorescent dyes and captures images of the sample for each... Agent: Institut National D'optique
20110183371 - Microbe-collecting carrier cartridge, carrier treating apparatus, and method of measuring microbes: A disposable microbe-collecting carrier cartridge and a carrier treating apparatus which efficiently convert microbes collected on a carrier into a solution and prevent variations in the amount of retrieval of microbes upon concentration on a filter are provided. A cartridge formed of an upper lid having a plurality of through... Agent:
20110183372 - Stimulated cell standards: Methods for producing stimulated, positive and negative control reference standard for monitoring intracellular cytokine levels and cytokine release in test samples by stimulating cells to produce cytokines in the presence of a cytokine release inhibitor, fixing the stimulated cells with a fixative such as paraformaldehyde, washing to remove excess fixatives... Agent: Health Protection Agency
20110183373 - Recombinant peptide production using a cross-linkable solubility tag: The invention relates to the recombinant expression of a peptide of interest in the form of a fusion protein comprising a solubility tag. The fusion protein comprises at least two portions separated by a cleavable peptide sequence wherein one portion is devoid of cysteine residues and the second portion comprises... Agent: E. I. Du Pont De Nemours And Company
20110183375 - Metal binding compounds and their use in cell culture medium compositions: The present invention is directed generally to metal binding compounds which may be added to cell culture media to replace factors required for cultivation of the cells (e.g. transferrin) which are of animal or human origin. More specifically, the invention is directed to metal binding compounds or complexes thereof comprising... Agent: Life Technologies Corporation
20110183374 - Thiopeptide precursor protein, gene encoding it and uses thereof: The present invention relates to the precursor proteins for thiopeptide biosynthesis, and the corresponding structural genes and uses thereof. The present invention also relates to methods for genetically manipulating the thiopeptide precursor protein or host cells expressing a gene encoding said thiopeptide precursor protein to produce thiopeptide compounds or their... Agent: Novartis Ag
20110183376 - Novel anti-igf-ir antibodies and uses thereof: The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR receptor, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic... Agent: Pierre Fabre Medicament
20110183377 - Methods, systems and reagents for improved immunodetection: The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which detect the FLAG epitope tag. Fusion proteins comprising the epitope tags, as well as methods of purifying these proteins and kits detecting... Agent:
20110183378 - Nucleic acid amplification method, nucleic acid amplification apparatus, and chip used in nucleic acid amplification: A nucleic acid amplification method includes introducing a liquid sample into a first chamber of a chip for use in nucleic acid amplification, the chip including a second chamber containing liquid that has a smaller specific gravity than the liquid sample and is immiscible with the liquid sample, injecting the... Agent: Seiko Epson Corporation
20110183379 - Flow process for pretreatment of lignocellulosic biomass: Described are methods for pretreating lignocellulosic biomass that comprise thermally conditioning the biomass by flow processing an aqueous slurry of the biomass through an outer passage(s) of one or more heat exchange devices while circulating a heat exchange fluid through an inner passage(s) of the heat exchange device(s). Also described... Agent:
20110183380 - Porous, carbohydrate-based foam structures and associated methods: Porous, carbohydrate-based foam structures and associated methods are disclosed. According to an aspect, a method can include using a starch solution. The starch solution can be precipitated to form starch nanoparticles having a predefined void structure.... Agent: North Carolina State University
20110183381 - Thermocellulases for lignocellulosic degradation: Thermostable cellulase enzyme systems comprising at least one each of a thermostable endoglucanase, an exo-processive-endoglucanase, and a β-glucosidase carry out the complete, coordinated hydrolysis of crystalline cellulose to monomeric glucose.... Agent: The Board Of Regents For Oklahoma State University
20110183382 - Methods and compositions for producing chemical products from c. phytofermentans: This invention provides systems and methods for the production of compounds by C. phytofermentans. C. phytofermentans is genetically-engineered for hydrolysis and fermentation of carbonaceous biomass to synthesize compounds of commercial value.... Agent: Qteros, Inc.
20110183383 - Compositions and methods of producing methionine: Described herein are microorganisms that produce methionine and related products from endogenous genes in a transsulfuration pathway, as well as from exogenous genes providing a direct sulfhydrylation pathway. Novel genes that are useful for methionine and SAMe production are disclosed.... Agent: Cj Cheijedang Corporation
20110183384 - Recombinant bacteria for producing deoxyviolacein and uses thereof: Recombinant bacteria for producing deoxyviolacein and uses thereof are provided, wherein the recombinant bacteria is obtained by introducing the deoxyviolacein synthesis-related gene cluster into Escherichia coli BL21-CodonPlus (DE3)-RIL or Pseudomonas putida mt-2. The deoxyviolacein synthesis-related gene cluster is obtained by knocking out VioD gene from the violacein synthesis-related gene cluster... Agent:
20110183385 - Method of extraction and yield-up of tricyclo compounds by adding a solid adsorbent resin as their carrier in fermentation medium: The present invention relates to a method of fermenting and purifying tricyclo compounds, specifically FK506 and/or FK520, and more particularly, to a method of purifying tricyclo compounds by adding a hydrophobic absorbent resin as a carrier in culturing FK506 and/or FK520 producing bacteria.... Agent:
20110183386 - Preparation of epsilon-caprolactam from (z)-6,7-dihydro-1h-azepin-2(5h)-one: The invention relates to a method for preparing ε-caprolactam comprising reducing the carbon-carbon double bond of (Z)-6,7-dihydro-1H-azepin-2(5H)-one, wherein the reduction is catalysed by a biocatalyst. The invention further relates to a novel host cell comprising a biocatalyst capable of catalysing said reduction and to a novel polynucleotide encoding a biocatalyst... Agent: DsmIPAssets B.v.
20110183387 - New mutant yeast strains capable of accumulating a large quantity of lipids: The subject of the present invention is a novel mutant yeast strain, particularly a Yarrowia lipolytica strain, capable of accumulate a large quantity of lipids. The said strain does not express the GUT2 gene. According to one variant, the invention relates to mutant yeast strains, particularly Yarrowia lipolytica strains, which... Agent:
20110183388 - Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms: The present invention is in the field of biosynthesis of polyhydroxyalkanoates (PHA). The invention relates to a genetically engineered microorganism having at least one gene involved in the metabolism, preferably in the production, of polyhydroxyalkanoates (PHA). This microorganism is useful in commercial production of polyhydroxyalkanoates. The present invention further relates... Agent:
20110183389 - Production of lactic acid from hemicellulose extracts: A method is provided for producing lactic acid comprising fermenting sugars derived from biomass using sugar consuming bacteria to produce lactic acid. In certain embodiments, the biomass is woody biomass, and the bacteria are pentose consuming bacteria such as Bacillus coagulans.... Agent:
20110183390 - Method of conversion of syngas using microorganism on hydrophilic membrane: A stable system for producing liquid products such as ethanol, butanol and other chemicals from syngas components contacts CO or a mixture of CO2 and H2 with a hydrophilic membrane under anaerobic conditions and transfers these components into contact with microorganisms contained as a biofilm on the membrane. Maintaining the... Agent:
20110183391 - Biosynthesis of phloroglucinol and preparation of 1,3-dihydroxybenzene therefrom: The present invention provides methods, enzymes, and cells for the biosynthetic production of phloroglucinol from malonyl-CoA, which is ultimately obtained from simple starting materials such as glucose; also provided are methods for preparing derivatives of biosynthetic phloroglucinol, including, e.g., resorcinol.... Agent: Board Of Trustees Of Michigan State Of University
20110183393 - Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids: The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or... Agent: Gevo, Inc.
20110183392 - Yeast organism producing isobutanol at a high yield: There is disclosed a method of producing isobutanol. In an embodiment, the method includes providing a microorganism transformed with an isobutanol producing pathway containing at least one exogenous gene. The microorganism is selected to produce isobutanol from a carbon source at a yield of at least 10 percent theoretical. The... Agent: Gevo, Inc.
20110183394 - Method of producing yeast biomass: The invention relates to use of a substrate comprising C5 compound-containing material, in the growth of Saccharomyces yeast or the production of a product of Saccharomyces yeast, wherein the C5 compound-containing material is: (a) C5 compound-containing material obtained from lignocellulosic hydrolysate; (b) C5 compound-containing material obtained from fermentation of lignocellulosic... Agent: Microbiogen Pty Ltdc C/o Peter Hunt & Associates
20110183395 - Processes for producing a fermentation product: The present invention relates to processes for producing a fermentation product, such as ethanol, from milled starch-containing material comprising (a) saccharifying the milled starch-containing material with a glucoamylase having an amino acid sequence shown in SEQ ID NO: 2, or a glucoamylase being at least 70% identical thereto, at a... Agent: Novozymes North America, Inc.
20110183396 - Production and use of yeast having increased cellulose hydrolysis ability: The present invention provides a method for producing an yeast having an increased cellulose hydrolysis ability. The method includes the step of introducing increased integration copy numbers of both a gene for an enzyme capable of hydrolyzing crystalline cellulose and a gene for an enzyme capable of hydrolyzing noncrystalline cellulose... Agent: Bio-energy Corporation
20110183397 - Carbonic anhydrase bioreactor and process: A triphasic bioreactor for physico-chemically treating a gas is disclosed. The triphasic bioreactor comprises a reaction chamber with a liquid and biocatalysts in suspension in the liquid, for catalyzing a reaction between the gas and the liquid to obtain a treated gas and a solution containing a reaction product. A... Agent: Co2 Solution Inc.
20110183398 - Microorganism-capturing compositions and methods: The invention relates to compositions, methods, devices, and kits for non-specifically isolating bacterial cells. The compositions comprise a solid support which has a surface comprising a combination of a carbohydrate and a biotin-binding protein, wherein the protein is covalently bonded to the carbohydrate, and wherein the protein is linked to... Agent: 3m Innovative Properties
20110183399 - Maize cellulose synthases and uses thereof: The invention provides isolated cellulose synthase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering cellulose synthase levels in plants. The invention further provides recombinant expression cassettes, host cells, and transgenic plants comprising said nucleic acids.... Agent: Pioneer Hi-bred International, Inc.
20110183400 - Process for production of lipases by genetic modification of yeast: The present invention relates to the construction of optimized synthetic lipase gene expression vectors for the high level expression of recombinant lipases in the yeast. The invention provides an enzymatic approach to the industrial processing of by-products resulting from biodiesel production.... Agent: Petroleo Brasileiro S.a.- Petrobras
20110183401 - Kappa-carrageenase and kappa-carrageenase-containing compositions: The present invention provides cleaning compositions comprising at least one carrageenase enzyme, methods for producing carrageenase enzymes in host cells, host cells comprising recombinant polynucleotides encoding at least one carrageenase, and recombinant polynucleotides encoding carrageenase.... Agent: Danisco US Inc.
20110183402 - Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy: Methods are provided for the synthesis and secretion of recombinant proteins preferably large mammalian proteins or hetero-multimeric proteins at high levels and for prolonged time in polyploid, preferably diploid yeast. These methods use various mating competent yeast, including Pichia. In a preferred embodiment, a first expression vector is transformed into... Agent:
20110183403 - Cell disruption of plant and animal raw materials by a combination of automization process with decompression processes for selective extraction and separation of interacellular valuable substances: A method for cell disruption of biogenic suspended raw materials by means of a combination of pressurization, atomization and decompression with a subsequent selective extraction and separation of cellular valuable substances includes at least one reservoir cubicle serving as reservoir for a suspension composed of biogenic raw material and at... Agent: Uhde High Pressure Technologies Gmbh
20110183404 - Method for processing porcine cornea for decellularization: Disclosed is a method for processing porcine cornea using an aqueous NaCl solution and an aqueous trypsin/EDTA solution to decellularize enucleated porcine cornea. The porcine cornea processed by the method causes neither inflammation nor immune rejection. The porcine corneal stroma decellularized by the method can be recellularized together with host... Agent: Snu R&db Foundation
20110183406 - Apparatus for separating tissue cells from a fluid: It is provided that inside the collection space (18) a communicating tube (16) is arranged, which terminates at a distance from the bottom (17) of the collection container (14), wherein a connection is provided between the communicating tube (16) and the collection space (18) above a fluid-tissue cell mixture level... Agent: Human Med Ag
20110183407 - Apparatus and method for tip alignment in multiwell plates: Apparatuses and methods of aligning at least one tip of a tip manifold with a plurality of wells of a multiwell plate. The tip manifold includes a plate, at least one tip depending from the plate, a first tip alignment pin depending from the plate, and a second tip alignment... Agent: Cellectricon Ab
20110183408 - Reagent cartridge for microorganism detection apparatus: A reagent cartridge for a microorganism detection apparatus includes a plurality of reagent vessels, a support plate, and side plates, wherein the reagent vessels are integrally connected with each other in parallel by the support plate, and a group of the plurality of the reagent vessels is surrounded by the... Agent: Hitachi Plant Technologies, Ltd.
20110183409 - Sealed chip package: The invention provides environmental packages, instruments, and methods for sealing, protecting, and providing analysis chips for processing and analysis. The analysis chips are bonded directly or indirectly to chip carriers which are held within the chambers of an environmental packaging strip. The chambers are sealed with a sealing film such... Agent: Pacific Biosciences Of California, Inc.
20110183410 - Biomass power plant: The invention relates to a biomass power plant for dry-wet simultaneous fermentation, having dry fermenter modules comprising dry fermenters. In order to refine the biomass power plant such that the length of the pipes for delivering process water is reduced to a minimum, the invention proposes to integrate a process... Agent:
20110183411 - Self-sterilizing automated incubator: A method and system for self-sterilizing an automated incubator is disclosed. The internal temperature of the automated incubator is elevated by forcing hot air to flow into the internal incubation chamber, wherein all mechanics and electronics associated with the automated plate mover are outside the internal incubation chamber. During sterilization,... Agent: Highres Biosolutions
20110183412 - Alteration of fc-fusion protein serum half-lives by mutagenesis: The present invention provides for a modified Fc-fusion protein in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified... Agent: Facet Biotech Corpration
20110183413 - Biologically active c-terminal arginine-containing peptides: The present invention concerns the separation, identification and characterization of active peptide fragments from peptones.... Agent:
20110183415 - Derivation of embryonic stem cells and embryo-derived cells: This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to... Agent:
20110183414 - Expansion medium for cd34-negative stem cells: This invention provides a cell growth medium comprising (a) a human platelet lysate free of solid matter greater than 0.22 μm in diameter, wherein the lysate constitutes from 2% to 15% of the total volume of the cell growth medium; (b) a human fresh frozen plasma (FFP) filtrate free of... Agent: Apceth Gmbh & Co. Kg
20110183416 - Method of modulating the proliferation of medullary thyroid carcinoma cells: The present invention is directed to a method of decreasing the rate of proliferation of medullary thyroid carcinoma cells which comprises contacting medullary thyroid carcinoma cells with one or more SSTR2 agonist. A preferred selective somatostatin receptor type-2 (SSTR-2) agonist cyclo[Tic-Tyr-D-Trp-Lys-Abu-Phe] is also disclosed.... Agent:
20110183417 - Polyamides for nucleic acid delivery: The present invention provides a new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications. In particular, these vectors can be used for gene transfer applications. These new gene transduction vectors can achieve transfer efficiencies far greater to commercially available polymeric and... Agent:
20110183418 - Peptide-polymer cell culture articles and methods of making: Functionalized peptide monomers, peptides that have been functionalized to contain a polymerization moiety, are disclosed. The use of these functionalized peptide monomers to form peptide polymers which are useful as synthetic surfaces capable of supporting culture of cells in culture, particularly cells that will be used therapeutically, is also disclosed.... Agent:
20110183419 - Silica sol material for producing bilogically degradable and/or resorbable silica gel materials, the production and use thereof: The invention concerns a novel silica sol material and its use for producing bioabsorbable and biodegradable silica gel materials having improved properties. The materials such as for example fibres, fibrous nonwoven webs, powders, monoliths and/or coatings are used, for example, in medical technology and/or human medicine, in particular for wound... Agent: Bayer Innvation Gmbh07/21/2011 > patent applications in patent subcategories.
20110177487 - Methods and apparatus for perfusion of an explanted donor heart: Described herein are methods and apparatus that may be used in various applications, such as to extend the viability of a donor heart, promote the efficacy for transportation of a donor heart, and/or reduce costs associated with donor heart transport and preservation. In one embodiment, the subject matter discloses an... Agent: Cedars-sinai Medical Center
20110177488 - Biological material and methods and solutions for preservation thereof: Provided is a preservation solution for preserving biological material at low temperature including one or more polyphenols and a method for preservation of biological material, the method includes adding the preservation solution to biological material, cooling the biological material and storing it under appropriate storing conditions. The present method may... Agent: Core Dynamics Limited
20110177489 - Specimen identification and dispensation device and specimen identification and dispensation method: A specimen identification and dispensation device includes an optical measurement device which is an identification part for measuring and identifying optical information on a specimen by emitting exciting light to the specimen being a measurement target dispersed in a liquid flowing through inside of a capillary, a dispensation part for... Agent: Furukawa Electric Co., Ltd.
20110177491 - Peptide for use in simultaneous protein quantification of metabolizing enzymes using mass spectrometric analysis apparatus: There are provided a peptide consisting of an amino acid sequence for simultaneously quantifying absolute amounts of metabolizing enzyme proteins in a biological sample at high sensitivity and a method for using the same. A peptide which can be detected at high sensitivity with a mass spectrometer that enables highly... Agent: Tohoku University
20110177495 - Continuous directed evolution of proteins and nucleic acids: The present invention discloses generalizable methods of evolving nucleic acids and proteins utilizing continuous directed evolution. The invention discloses methods of passing a nucleic acid from cell to cell in a desired function-dependent manner. The linkage of the desired function and passage of the nucleic acid from cell to cell... Agent: President And Fellows Of Harvard College
20110177494 - Device and method for pressure-driven plug transport: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.... Agent: The University Of Chicago
20110177492 - Method of classifying chemically crosslinked cellular samples using mass spectra: A method of analyzing cellular samples that include a chemically crosslinked analyte is provided. The analysis typically involves the use of mass spectrometry.... Agent: 3m Innovative Properties Company
20110177493 - Using highly sensitive suspended carbon nanotubes for molecular-level sensing based on optical detection: A molecular sensor is provided that contains at least one carbon nanotube suspended on a suitable support structure. In one aspect, at least one receptor is attached to a surface of the suspended carbon nanotube. Also provided are methods of detecting an analyte in a sample by contacting a sample... Agent: The Regents Of The University Of California
20110177498 - Base-detecting pore: The invention relates to a mutant α-hemolysin (α-HL) pore which is useful for detecting one or more nucleotides by stochastic sensing. The pore is particularly useful for sequencing DNA or RNA. A molecular adaptor that allows detection of the nucleotide(s) is covalently attached to the pore. The pore is specifically... Agent: Oxford Nanopore Technologies Limited
20110177496 - Field-switch sequencing: The present invention provides novel compositions, methods and apparatus for DNA sequencing that can be performed, e.g., in a two-electrode chamber. The present invention also provides a method for sequencing a nucleic acid comprising immobilizing a plurality of complexes comprising a target nucleic acid, a primer nucleic acid, and a... Agent: Pacific Biosciences Of California, Inc.
20110177499 - Methods and systems for molecular fingerprinting: This invention relates in general to a method for molecular fingerprinting. The method can be used for forensic identification (e.g. DNA fingerprinting, especially by VNTR), bacterial typing, and human/animal pathogen diagnosis. More particularly, molecules such as polynucleotides (e.g. DNA) can be assessed or sorted by size in a microfabricated device... Agent: California Institute Of Technology
20110177497 - Thermus thermophilus nucleic acid polymerases: The invention provides novel nucleic acid polymerases from strains GK24 and RQ-1 of Thermus thermophilus, and nucleic acids encoding those polymerases, as well as methods for using the polymerases and nucleic acids.... Agent: Life Technologies Corporation
20110177506 - Amplification of trp1 for specific detection of phytophthora ramorum: Phytophthora ramorum is currently a devastating disease for many plant species and infection presents significant economic problems, and in particular has lead to devastating effects on many specie of oak trees. The present invention provides methods and kits for selective detection of Phytophthora ramorum by amplification of indole-3-glycerol-phosphate synthase N-5′-phosphoribosyl... Agent: Agdia
20110177501 - Biosensor for detection and visualisation of single-stranded dna: A modified protein of the single strand DNA-binding domain, SSB family comprising a detectable label is disclosed. The label has detectable characteristics which alter on binding single stranded DNA. The protein is thus useful in an assay for single stranded DNA.... Agent: Medical Research Council
20110177503 - Cardiac risk stratification by nos1ap genotyping: A risk-conferring genetic modifier is found in a large LQTS cohort. A NOS1AP tag SNP genotype provides an additional clinical assessment, which helps assess risk and choice of therapeutic strategies in LQTS as well as other conditions such as Brugada Syndrome, and catecholaminergic polymorphic ventricular tachycardia (CPTV).... Agent:
20110177505 - Dna methylation analysis of regulatory t cells through dna-methylation analysis of the tsdr region of the gene foxp3: The present invention relates to a method, in particular an in vitro method for identifying FoxP3-positive CD25+CD4+ regulatory T cells of a mammal, comprising analyzing the methylation status of at least one CpG position in the FOXP3 gene, in particular its “upstream” regulatory regions, and in particular the promoter and... Agent:
20110177502 - Identification of pediatric onset inflammatory disease loci and methods of use thereof for the diagnosis and treatment of the same: Compositions and methods for detection and treatment of inflammatory bowel disease are provided.... Agent:
20110177500 - Immunohistochemistry detection method: The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (IHC) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from... Agent: Dako Denmark As
20110177510 - Method and probe set for detecting cancer: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer... Agent:
20110177511 - Method for determining breast cancer metastasis and method for evaluating serum: It is determined that the breast cancer has metastasized when methylation is detected in the CpG island of at least one selected from the group consisting of GSTP1, RASSF1A and RARb by detecting methylation in CpG island of each of GSTP1, RASSF1A and RARb contained in serum obtained from a... Agent:
20110177504 - Methods for detecting inflammatory bowel disease: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.... Agent:
20110177507 - Oligonucleotides for genotyping thymidylate synthase gene: Oligonucleotides for genotyping the thymidylate synthase gene are provided. The number of tandem repeats in the promoter region of the thymidylate synthase gene can be identified based on the hybridization of an oligonucleotide of the invention to the genomic DNA of a subject. Therefore, the genotype of the thymidylate synthase... Agent: F. Hoffmann-la Roche Ag
20110177509 - Risk factors and a therapeutic target for neurodegenerative disorders: Compositions and methods for detecting a neurodegenerative disorder, and methods of treating a neurogenerative disorder are disclosed. Biomarkers for a neurodegenerative disorder containing a polymorphism in the nucleotide sequence of PP3R1, GSK3beta, PPP3CA, FYN, WISP1, MGEA5, CTSD, F2, MAPT, OGT or PRKCA are also disclosed. A method for detecting a... Agent: The Washington University
20110177508 - Universal methylation profiling methods: This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. This invention also provides neobases and methods of sequencing for methylation patterns using neobases.... Agent:
20110177515 - Compositions for use in identification of francisella: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of bacteria which are members of the Francisella genus by amplification of a segment of bacterial nucleic acid followed by molecular mass analysis.... Agent: Ibis Biosciences, Inc.
20110177520 - Dna sequencing method: A method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and processes along the polynucleotide. The detection of a conformational change may be carried out by measuring changes in a fluorophore bound to the enzyme.... Agent:
20110177514 - Integrated instrument performing synthesis and amplification, and a system and method thereof: An integrated instrument for oligonucleotide synthesis and PCR, and a system and method thereof are disclosed. The integrated instrument is basically composed of two independent modules. The first module is a unit for chemical de novo synthesis of oligonucleotides such as oligonucleotide primers and/or oligonucleotide hybridization probes. The second module... Agent: Roche Diagnostics Operations, Inc.
20110177512 - Method for assuring amplification of an abnormal nucleic acid in a sample: The invention generally relates to methods for assuring amplification of an abnormal nucleic acid that is present as a percentage of total nucleic acid in a sample. In certain embodiments, methods of the invention involve providing a sample from a subject, in which the sample includes a total of nucleic... Agent: Predictive Biosciences, Inc.
20110177519 - Method for detecting functional mold, method for evaluating functional mold-containing product and primer pair: The present invention provides a method of detecting a functional filamentous fungus, wherein the functional filamentous fungus, Coprinellus curtus, in a sample is detected using at least one polynucleotide selected from the group consisting of polynucleotides having a nucleotide sequence shown in SEQ ID NO: 1, SEQ ID NO: 2,... Agent: National University Corporation Shizouka Universit Y
20110177518 - Methods and devices for micro-isolation, extraction, and/or analysis of microscale components: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The... Agent:
20110177513 - Nucleic acid amplification: A method for determining the presence and/or amount of a first polynucleic acid in a sample comprising subjecting the sample to nucleic acid amplification in which product is detectable by the presence of a signal generated by polynucleic acid formation from the first polynucleotide characterised in that the nucleic acid... Agent:
20110177517 - Partition defined detection methods: Methods are disclosed for resolving measurement problems such problems in measuring chromosomal copy number. Some disclosed methods involve first selecting a primary assay element characteristic to partition. Such characteristic may be a source of experimental variability such as the GC content of measured DNA sequences. Additionally, the disclosed methods may... Agent: Artemis Health, Inc.
20110177516 - Rapid analytical method for mixed biological samples: The present invention relates to a rapid method for the amplification of nucleic acids from biological samples which contain a mixture of different cells or a mixture of cells with contaminating components, in which such cells are lysed in a lysis solution (A) and the lysate can be used immediately... Agent: Qiagen Gmbh
20110177521 - Methods and kits for isolating nucleic acid from an organism: The invention generally relates to methods and kits for isolating nucleic acids from an organism. In certain embodiments, methods of the invention involve contacting a plurality of lytic enzymes to an organism, thereby lysing a cell wall of the organism to release the nucleic acid, and introducing at least one... Agent: Opgen, Inc.
20110177522 - Methods for producing olfactory gpcrs: The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell... Agent:
20110177523 - Methods of analyzing samples for bacteria using whole cell capture and atp analysis: The invention relates to methods of capturing bacterial whole cells that includes the use of one or more antibodies having antigenic specificities for one or more distinct analytes characteristic of the specific bacterium, followed by analyzing the target whole cells using a direct or indirect ATP assay.... Agent:
20110177524 - Recombinant fibrinogen: The present invention relates to nucleotide sequences encoding a fibrinogen alpha, beta or gamma chain. The sequences are optimized for expression in a eukaryotic cell culture system. Such optimized nucleotide sequences allow for the efficient expression of recombinant fibrinogen and variants thereof in intact form in a eukaryotic cell culture... Agent: Profibrix Bv
20110177525 - Antibodies and methods of diagnosing diseases: The present invention generally relates to antibodies and use of these antibodies in diagnostic assays for various disease states, including cancer. In certain embodiments, the invention provides an isolated human or humanized antibody or functional fragment thereof including an antigen-binding region that is specific for an epitope on a protein,... Agent: Predictive Biosciences, Inc.
20110177528 - Methods for detecting and inhibiting angiogenesis: The present invention provides methods for reducing or inhibiting angiogenesis in a tissue, by contacting α5β1 integrin in the tissue with an agent that interferes with specific binding of the α5β1 integrin to a ligand expressed in the tissue; and methods of identifying angiogenesis in a tissue, by contacting the... Agent: The Regents Of The University Of California
20110177529 - Rapid nasal assay kit: The present invention relates to an assay which can be used on nasal secretions. The assay is used to determine the cause of nasal secretions, for example whether the secretions are due to an allergic reaction or a non-allergic reaction.... Agent: Toxcure, LLC
20110177526 - Janus family kinases and identification of immune modulators: An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells.... Agent: The United States Of America, As Represented By The Secretary, Dept., Of Health & Human Services
20110177527 - Methods and compounds for testing binding of a ligand to a g protein-coupled receptor: The present invention relates to compounds and methods for testing for the binding of a ligand to a G Protein-Coupled Receptor. In particular, the compounds of the invention are useful in high throughput screening for ligands which bind to G Protein-Coupled Receptors.... Agent: Ge Healthcare Uk Limited
20110177533 - Asbestos exposusre, pleural mesothelioma, and osteopontin levels: The present invention provides prognostic and diagnostic methods related to pleural mesotheliomas based on levels of osteopontin in bodily fluids.... Agent: Wayne State Unitersity
20110177531 - Cell-based complement activation product algorithm for diagnosing systemic lupus erythematosus: The present invention provides methods of diagnosing and monitoring systemic lupus erythematosus by measuring cell-based complement activation products (CB-CAPS) in a subject's blood. In particular, the invention describes a diagnostic method employing the measurement of multiple complement activation products on the surfaces of red blood cells, white blood cells, and... Agent: Exagen Diagnostics, Inc.
20110177534 - Diagnostics for membranous nephropathy: The invention relates to immunoassays, reagents, therapeutics and methods of diagnosing and prognosis evaluation of idiopathic membranous nephropathy (MN). Immunoassays comprise enzyme-linked immunoabsorbent assays and nephelometric immunoassays for serum auto-antibodies reactive against a phospholipase A2 receptor (PLA2R). Therapeutic methods include removal of the auto-antibodies by absorbance or administration of soluble... Agent: Le Centre National De La Recherche Scientifique
20110177532 - Immunomodulating compositions and methods of use thereof: The invention is directed to β1-6 glucans, compositions, diagnostic kits, and devices comprising the same, and methods of use thereof in modulating immune response and treating, delaying progression of, reducing the incidence or severity of cancer, infection, inflammation, and autoimmune diseases. The β1-6 glucans of certain embodiments of the invention... Agent:
20110177535 - Method of detecting or monitoring a malignant plasma cell disease: e
20110177530 - Methods and compositions for detection of biological materials using microfluidic devices: Provided herein are microfluidic devices and methods useful for sensitive detection of analytes. The methods and devices described herein are also useful for detecting direct or indirect binding of enzymes or catalysts to a surface, for example a surface having analytes bound thereon. Methods disclosed herein include embodiments utilizing a... Agent:
20110177536 - Novel antibodies recognizing native annexin a3: The present invention refers to novel antibodies recognizing native annexin A3. These antibodies are suitable for diagnostic and therapeutic applications.... Agent: Proteosys Ag
20110177537 - Method and system for measuring a sample to determine the presence of and optionally treat a pathologic condition: The present invention provides diagnostic in vitro methods as well as kits and devices to be used in the methods of the present invention for diagnosis or prognosis of a pathologic condition characterized by the presence/absence of an endogenous hormone and/or hormone analog(s) thereof involved in diabetes or metabolic syndrome.... Agent: Becton, Dickinson And Company
20110177538 - Biomarkers for rheumatoid arthritis (ra): The invention provides methods for predicting and compositions for use in the prediction of rheumatoid arthritis (RA) based upon the simultaneous measurement of at least two biomarkers in a biological sample. The invention further relates to methods for following the efficiency of a treatment against RA and to methods for... Agent:
20110177539 - Covalently linked thermostable kinase for decontamination process validation: A biological process indicator is provided for validating a treatment process in which the amount or activity of a contaminant in a sample is reduced. The indicator comprises a thermostable kinase covalently linked to a biological component, with the proviso that the biological component is not an antibody. Methods of... Agent: Health Protection Agency
20110177540 - Mutant luciferase: An isolated recombinant luciferase having luciferase activity. The recombinant luciferase has an amino acid sequence which differs from the wild-type luciferase from Photinus pyralis, Luciola mingrelica, Luciola cruciata, Luciola lateralis, Hotaria parvula, Pyrophorus plagiophthalamus, Lampyris noctiluca, Pyrocoelia miyako or Photinus pennsylvanica. In the sequence of the recombinant luciferase, the amino... Agent:
20110177541 - Method for adjusting the coagulation time in calibrator or control plasmas: A method for adjusting the coagulation time during the manufacture of calibrators and controls produced from frozen plasma or plasma treated for lyophilization thereof, for haemostatis tests relating to assaying and to monitoring anticoagulant treatments in a patient. The plasmas selected to prepare the calibrator plasmas or the control plasmas... Agent: Diagnostica Stago
20110177545 - G-proteins: Gαq-Gustducin chimeric G-proteins that functionally couple to G-protein coupled receptors. The chimeras can be expressed in heterologous cell systems and can be used as the basis of assays for identifying modulators of taste response, in particular bitter, sweet or umami taste responses.... Agent: Givaudan Sa
20110177544 - Method for distinguishing and sorting of cells and device therefor: A method for distinguishing and sorting cells characterized by comprising distinguishing and sorting a specific cell mass or a part of the cells in the cell mass with the use of transmitted light data reflecting the morphological characteristics of the cells such as size and shape optionally together with side-scattering... Agent: Furukawa Electric Co., Ltd.
20110177542 - Method for enhancing cellobiose utilization: The present invention relates to methods for improving a host cell's ability to utilize the disaccharide cellobiose. In some embodiments, a transformed cell expresses intracellular β-glucosidase. In other embodiments, a transformed host cell is able to grow on media wherein cellobiose is the sole carbon source. In other embodiments, selection... Agent: Stellenbosch University
20110177546 - Method of detecting bioactive molecules in a fluid sample: A method of detecting the presence of bioactive molecules in a fluid sample, comprising contacting a solution of a microorganism selected from the group consisting of a monocellular algae and a cyanobacteria with the fluid sample so as to obtain a formulation having a microorganism concentration of 200 000-1×107 cells/mL... Agent: Labbell Inc.
20110177543 - Regulation of bace degradation: The invention relates to methods and products for diagnosing, preventing, and treating Alzheimer's disease and abnormal production of amyloid β.... Agent: The General Hospital Corporation
20110177547 - Particle sorting using fluid streams: A fluidic device includes an arrangement of channels for introducing a sample containing particles of interest into a processing chamber. The chamber is in fluid communication with collecting channels via low-flow connection channels. Particles in the sample may be observed and diverted from the processing chamber by application of a... Agent: Arryx, Inc.
20110177548 - Fluorescent microscope slide: An apparatus and method for increasing the efficiency of finding a field of focus, and for increasing the accuracy of field of view in reading slides with fluorescent microscopy technology, including tuberculosis slides.... Agent:
20110177549 - Method, kit and system for culturable cell count: The present invention provides a method, kit and system for determining a quantitative value indicative of the number of culturable microbial cells, such as E. Coli, Ps. Aeruginosa or a mixture of microbial cells (e.g. for total microbial count) in a tested sample, the method comprising (i) contacting the tested... Agent: Tacount Exact Ltd.
20110177551 - Method for producing a chemical product and continuous fermentation apparatus: To control flow velocity of a culture liquid inside a membrane separation tank without giving influences to culture conditions in the fermentation tank, and also suppress precipitation of microorganisms or culture cells so that the production efficiency of the chemical product can be improved, in a method for producing a... Agent: Toray Industries, Inc.
20110177550 - Process for the treatment of water and production of biomass and associated systems: A process for the treatment of a saline water including: treating the water to adjust the salinity thereof and produce treated water having a predetermined salinity level; and directing at least a portion of the treated water having said predetermined salinity level to a bioreactor housing a microalgae for generating... Agent: Brinemag Pty Ltd
20110177552 - Systems and methods for producing plastid proteins: Methods and systems that include a method comprising: providing a system comprising one or more plastid proteins comprising a signal sequence and one or more chloroplast processing enzymes; and allowing at least one of the one or more chloroplast processing enzymes to cleave at least a portion of a signal... Agent:
20110177553 - Preparation of an esterase: The present invention relates to a recombinant E. coli strain characterized in that the organisms contains a gene coding for a protein having esterase activity. Such E. coli is suitable for the preparation of a protein with esterase activity, whereby the expression takes place without coexpression of GroEL and/or GroES... Agent:
20110177554 - Secreted frizzled related protein, sfrp, fragments and methods of use thereof: The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt... Agent: The University Of Massachusetts
20110177555 - Chinese hamster ovary cell lines: We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I (RCA-I).... Agent: Agency For Science, Technoogy And Research (a*star)
20110177556 - Nucleic acids encoding chimeric cd154 polypeptides: The present invention provides for an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an extracellular subdomain of non-human CD154, preferably murine CD154, that replaces a cleavage site of human CD154, and a second nucleotide sequence encoding an extracellular subdomain of human CD154 that binds... Agent: The Regents Of The University Of California
20110177557 - Fusion protein and use thereof: The invention relates to a fusion protein and a method for the generation of the fusion protein of the invention. Further, the invention relates to the use of the fusion protein of the invention for the generation of induced pluripotent cells. Moreover, the invention relates to a composition comprising at... Agent: Life & Brain Gmbh
20110177560 - Cellulosic protein expression in yeast: The present invention provides for combinations of enzymes and other proteins that result in improved saccharification of plant material. The invention provides for saccharification in the presence of and optional fermentation by, yeast cells expressing the enzymes and other proteins.... Agent: Edeniq, Inc.
20110177558 - Dispersing feedstocks and processing materials: Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce ethanol. Biomass feedstock is dispersed in a liquid medium... Agent: Xyleco, Inc.
20110177561 - Novel cbh1 homologs and varian cbh1 cellulase: Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or... Agent: Danisco US Inc.
20110177559 - Processing materials: Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce ethanol. Biomass feedstock is saccharified in a vessel by... Agent: Xyleco, Inc.
20110177563 - High throughput device for performing continuous-flow reactions: A high-throughput device is structured to perform a continuous-flow reaction, e.g., a polymerase chain reaction (PCR) requiring repetitive temperature control in a timely fashion.... Agent: Bioneer Corporation
20110177562 - Portable preparation, analysis, and detection apparatus for nucleic acid processing: The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through... Agent: Life Technologies Corporation
20110177564 - Bioprocess and microbe engineering for total carbon utilization in biofuel production: Some aspects of this invention provide methods and bioreactors for converting a carbon source into a lipid. In some embodiments, lipid production is carried out in an aerobic fermentor and carbon dioxide generated during lipid production is converted into a carbon substrate by CO2 fixation in an anaerobic fermentor. In... Agent: Massachusetts Institute Of Technology
20110177565 - Isolated polypeptide for increasing activity of polysaccharide hydrolase and methods of use: An isolated polypeptide is disclosed that improves the hydrolyzing capacity of a polysaccharide hydrolase such as cellulase, is capable of binding to a polysaccharide, is deficient in polysaccharide hydrolase activity, and includes a GH45 or a pollen-allergen domain. Methods of hydrolyzing polysaccharides using the isolated polypeptide are also disclosed.... Agent: Samsung Electronics Co., Ltd.
20110177566 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family: A method for producing an L-amino acid is described using a bacterium of the Enterobacteriaceae family, wherein the bacterium contains a protein which is able to confer resistance to growth inhibition by L-cysteine.... Agent:
20110177567 - Mild alkaline pretreatment and simultaneous saccharification and fermentation of lignocellulosic biomass into organic acids: The invention relates to a method for the production of a fermentation product from lignocellulosic biomass, to a reactor to carry out the method and to use of the reactor to produce a fermentation product.... Agent:
20110177568 - Method of l-lysine production: The present invention relates to a method of microbial production of L-lysine from methanol and other substrates, and particularly improving the production of L-lysine from such substrates. The invention concerns a method for producing lysine in B. methanolicus, said method comprising overexpressing an aspartate kinase III (AKIII) enzyme in said... Agent:
20110177569 - Mutant of propionyl-coa transferase from clostridium propionicum and preparing method for pla or pla copolymer using the same: Provided is a mutant of propionyl-CoA transferase from Clostridium propionicum that can convert lactate into lactyl-CoA with high efficiency in a method of preparing a polylactate (PLA) or PLA copolymer using microorganisms. Unlike conventional propionyl-CoA transferase which is weakly expressed in E. coli, when a mutant of propiony-CoA transferase from... Agent: Lg Chem, Ltd.
20110177570 - Bacterial mutants for enhanced succinate production: The present invention relates to a method for obtaining enhanced metabolite production in micro-organisms, and to mutants and/or transformants obtained with said method. More particularly, it relates to bacterial mutants and/or transformants for enhanced succinate production, especially mutants and/or transformants that are affected in the import and export of succinate.... Agent:
20110177571 - Designer calvin-cycle-channeled production of butanol and related higher alcohols: Designer Calvin-cycle-channeled and photosynthetic NADPH-enhanced pathways, the associated designer genes and designer transgenic photosynthetic organisms for photobiological production of butanol and related higher alcohols from carbon dioxide and water are provided. The butanol and related higher alcohols include 1-butanol, 2-methyl-1-butanol, isobutanol, 3-methyl-1-butanol, 1-hexanol, 1-octanol, 1-pentanol, 1-heptanol, 3-methyl-1-pentanol, 4-methyl-1-hexanol, 5-methyl-1-heptanol, 4-methyl-1-pentanol,... Agent:
20110177572 - Method of cultivating fermentative yeast used for xylose fermentation of non-detoxified lignocellulosic hydrolysate: A hydrolysate-adapted yeast, Pichia stipitis INER 1128, is cultivated according to the present invention. The adapted yeast can effectively convert xylose into ethanol in lignocellulosic hydrolysate, which is not even detoxified. Well ethanol yield is obtained while xylose is not wasted and thus cost is reduced.... Agent: Atomic Energy Council-institute Of Nuclear Energy Research
20110177573 - Microbial treatment of lignocellulosic biomass: Aspects of the present invention relate to methods of microbially treating lignocellulosic biomass using cellulose- and/or hemicellulose-degrading bacteria. In certain embodiments, the microbially treated material is then subjected to thermal and/or chemical pretreatment. In tandem with the microbial treatment the thermal and/or chemical pretreatment may result in the production of... Agent:
20110177574 - Method and apparatus for processing waste containing fermentable raw material: The invention relates to a method and an apparatus for processing waste (1) containing fermentable raw materials selected from sugars and raw materials such as starch and cellulose capable of being saccharified into fermentable sugars. The method includes a crushing step for forming fine-divided waste (30), a saccharification step for... Agent:
20110177575 - Production of hydrocarbons in microorganisms: A recombinant microorganism employing a bacterial pathway to produce a cyclic amino acid (e.g., coronamic acid or norcoronamic acid) and a plant enzyme (ACC oxidase) to oxidize the amino acid and produce an alkene (e.g., 1-butene or propene) is provided herein. Expression of these two biosynthetic modules in various microbial... Agent:
20110177576 - Shock wave cell treatment device and method to enhance cell replication: A device 100 for treating cells or cultures of cells comprises: a fluid holding tank 100T, having sides or walls 101, 102, 103, 104 and a bottom 105, with an opening 39 in a wall or side for receiving an applicator 200M for transmitting energy into a holding tank 100T... Agent: Tissue Regenerationtechnologies, LLC.
20110177577 - Enhancement of vanadium-containing phosphatase inhibitors: The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention also concerns the use of the inventive composition for... Agent:
20110177578 - Aptamer against il-17 and use thereof: The invention provides an aptamer possessing an inhibitory activity against IL-17, as well as a complex comprising an aptamer possessing a binding activity or inhibitory activity against IL-17 and a functional substance (for example, affinity substances, substances for labeling, enzymes, drug delivery vehicles, drugs and the like). The invention also... Agent: The University Of Tokyo
20110177579 - Thermostable alcohol dehydrogenase derived from thermococcus guaymasensis: An alcohol dehydrogenase (ADH) from hyperthermophilic archaeon Thermococcus guaymasensis was purified to homogeneity and was found to be a homotetramer with a subunit size of 40±1 kDa. The gene encoding the enzyme was cloned and sequenced, and found to have significant sequence homology to known zinc-containing ADHs and L-threonine dehydrogenases... Agent:
20110177580 - Method of controlling a polypeptide modification reaction: The invention relates to a method of controlling a polypeptide modification reaction, in particular but not exclusively, a method of controlling the activation of human factor VII (FVII) to produce human factor VII(a) (FVII(a)). The invention also relates to polypeptides obtainable by the polypeptide modification reaction and to pharmaceutical compositions... Agent: Novo Nordisk Healthcare Ag
20110177581 - Mutant mt-sp1 proteases with altered substrate specificity or activity: MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.... Agent:
20110177582 - Production of protein isolates: Embodiments of the process for isolating proteins from a defatted meal comprise extracting the defatted meal with an acidic solvent at a pH of between 2 and 6 to obtain a mixture of treated meal and a first solution of proteins. The process further comprises extracting the treated meal with... Agent:
20110177583 - Automated rinse water and body fluid bioagent detection: Testing of the foot soldier or other person on the battlefield for bioagent contamination is facilitated by a computer controlled portable testing unit that combines a sink or other receptacle (1), an automated ELISA tester (3), and means to transport fluids (10, 9, 11, 15) stemming from the soldier deposited... Agent:
20110177584 - Acoustic wave sensor and detection method using acoustic wave sensor: An acoustic wave sensor having significantly increased sensitivity and excellent sensing reproducibility and stability includes a piezoelectric substrate, an acoustic wave element including an electrode disposed on the piezoelectric substrate, and a reactive membrane which overlies the acoustic wave element and which is reduced in mass by direct or indirect... Agent: Murata Manufacturing Co., Ltd.
20110177586 - Device and method for pressure-driven plug transport: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.... Agent: The University Of Chicago
20110177585 - Rapid detection nanosensors for biological pathogens: An apparatus for the rapid detection of multiple pathogens using a FRET-based phenomenon. A volume of fluid, possibly containing pathogens, is passed through an intake and combined with an assay solution of quantum dot/antibody-antigen/quencher complexes that dissociate and recombine with the pathogens into quantum dot/antibody-pathogen complexes. The quantum dot/antibody-antigen/quencher and... Agent: Epir Technologies, Inc.
20110177587 - Nucleic acid amplification with continuous flow emulsion: Embodiments of the present invention are directed to methods and devices/systems for amplifying genetic material and may include providing a water-in-oil emulsion in a continuous flow. The emulsion may include a plurality of water droplets comprising microreactors. Each of the plurality of microreactors may include a single bead capable of... Agent: 454 Corporation
20110177588 - Method and apparatus for disrupting cells and purifying nucleic acid using a single chip: Provided herein is a method and apparatus for disrupting cells and purifying nucleic acids in a single chip. The method comprises irradiating a chip with a laser beam, wherein the chip comprises a solid support on which a cell lysis enhancing metal oxide layer, and a cell binding metal oxide... Agent: Samsung Electronics Co., Ltd.
20110177590 - Bioprinted nanoparticles and methods of use: The present invention provides compositions and methods that combine the initial patterning capabilities of a direct cell printing system with the active patterning capabilities of magnetically labeled cells, such as cells labeled with superparamagnetic nanoparticles. The present invention allows for the biofabrication of a complex three-dimensional tissue scaffold comprising bioactive... Agent: Drexel University
20110177592 - Magnetic apparatus for blood separation: An apparatus for magnetically separating constituents of blood includes: a first portion having a solid support haying fixedly attached thereon a plurality of ring magnets, each ring magnet defining an interior perimeter enclosing an aperture; and a second portion removably attached to the first portion, wherein the second portion includes... Agent:
20110177591 - Method and device for producing dermis: A process and a device for preparing a dermis implant of a predefinable thickness provides for a section of skin (30) to be laid on a plate (20). Subcutaneous material is removed with a milling cutter (40) until the skin is of the desired thickness.... Agent: Tutogen Medical Gmbh
20110177589 - Novel human polyomavirus: Provided herein is a novel human polyomavirus, its nucleic acid sequence, as well as methods to detect and diagnosis the presence of the polyomavirus.... Agent:
20110177593 - Low rigidity gels for msc growth modulation: This invention provides gels and matrices having a rigidity in the range of 0.1-2.5 kPa, methods of manufacturing same, and method of preserving a mesenchymal stem cell population or studying mesenchymal stem cells, comprising same.... Agent: Makoto Funaki
20110177594 - Stem cells culture systems: Provided are systems and methods for providing human cell cultures. Further provided are cultures of feeder cells for use in stem cell technology, as well as cultures, culture systems and methods for maintenance and propagating of stem cells in an undifferentiated state as well as for the development of somatic... Agent: Hadasit Medical Research Services & Development Limited
20110177595 - Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof: Methods and compositions are provided for circularizing target sequences in a sample. In particular, ligation oligonucleotides are employed to selectively hybridize with the target such that the target can be ligated into a closed circular target. Rolling circle amplification can then be performed directly on the target sequence for subsequent... Agent: Regents Of The University Of Minnesota
20110177596 - Device for enhancing immunostimulatory capabilities of t-cells: T-cells are generated with enhanced immunostimulatory capabilities for use in self therapy treatment protocols, by utilizing a biodegradable device with a biodegradable support that has one or more agents that are reactive to T-cell surface moieties. The biodegradable devices are mixed with the T-cells sufficiently so that the one or... Agent: Immunovative Therapies Ltd.
20110177597 - Cellular differentiation process and its use for blood vessel build-up: b. or a second group of specialized differentiated cells under hypoxic conditions, in a culture medium of the same nature as the one used for obtaining the first group of specialized differentiated cells; the first and second groups of specialized differentiated cells retaining the functional properties of the corresponding specialized... Agent: Universite Henri Poincare Nancy 1
20110177598 - Method for cellular tissue multiplication from jatropha curcas: The method of the present invention comprises: Obtaining an explant from the seeds of Jatropha curcas; Putting the explant derived from the seed of Jatropha curcas in a culture medium; Breaking the intercellular unions of the explants tissue, which generates individuals cells; Incubating for a determined time the culture medium... Agent:
20110177599 - Delivery of nucleic acids across membranes: The present invention provides for methods and compositions for introducing integral membrane proteins into cell membranes and, optionally, delivery of nucleic acids across membranes via the integral membrane proteins.... Agent: Bio-rad Laboratories, Inc.
20110177600 - Protein production using eukaryotic cell lines: The subject invention provides a site-specific integration system and methods for generating eukaryotic cells lines for protein production. The provided system includes a first site-specifically integrating target vector and a second site-specifically integrating donor vector comprising a gene of interest. Also provided are mammalian cell lines produced by the subject... Agent:07/14/2011 > patent applications in patent subcategories.
20110171624 - Media solutions and methods for cryopreservation and thawing of in vitro fertilization specimens: A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C, antioxidants, fatty acids to supply the specimens with... Agent:
20110171625 - Media solutions and methods for cryopreservation and thawing of in vitro fertilization specimens: A medium solution which will increase the growth, survival and ultimately the live birth rate of oocytes and embryos which have been or will be subjected to cryopreservation. The solution contains varied amounts of glucose, pyruvates, amino acids, vitamins K5 and C, antioxidants, fatty acids to supply the specimens with... Agent:
20110171626 - Electron-irradiated physiological isotonic solution and electron irradiation apparatus for preparing electron-irradiated physiological isotonic solution and organ preservation container: An infusion solution bag 11 filled with a physiological saline and an infusion pump 12 are connected to an electron irradiation apparatus 13. The electron irradiation apparatus 13 is connected to a DC-type high voltage generator 2 connected with a DC power supply 1. Using the electron irradiation apparatus 13,... Agent:
20110171628 - Cervical screening algorithms: This invention describes new protocols for screening for cervical carcinomas or high-grade premalignant cervical lesions based on combinations of testing for the presence of high-risk HPV, HPV genotyping, marker analysis, and/or cytology. With these protocols the number of women that have to undergo follow-updiagnostic testing and/or clinical examinations will decrease.... Agent: Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg
20110171629 - Nanostructured devices including analyte detectors, and related methods: The present invention provides compositions and devices comprising nanostructure networks, and related methods. The compositions may exhibit enhanced interaction between nanostructures, providing improved device performance (e.g., improved conductivity). In some embodiments, the devices are capable of interacting with various species to produce an observable signal from the device. In some... Agent: Massachusetts Institute Of Technology
20110171627 - Zcytor19 heterodimeric cytokine receptor polynucleotides, polypeptides, antibodies and methods: Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention... Agent: Zymogenetics, Inc.
20110171632 - Loss of heterozygosity of the dna markers in the 12q22-23 region: A method of detecting DNA markers in the 12q22-23 region. The method comprises providing a sample containing acellular DNA from a subject and detecting one or more DNA markers in the 12q22-23 region in the sample. Also disclosed are methods of diagnosing and monitoring cancer; methods of determining the efficacy... Agent:
20110171633 - Method to use gene expression to determine likelihood of clinical outcome of renal cancer: The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.... Agent:
20110171630 - Methods and compositions for correlating genetic markers with cardiovascular disease: The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more... Agent: Duke University
20110171634 - Methods and devices for single-molecule whole genome analysis: Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.... Agent: Bionanomatrix, Inc.
20110171631 - Methods of diagnosing endometriosis: The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with... Agent: The Regents Of The University Of California
20110171636 - Mono- and multi-element coded libs assays and methods: Methods for tagging an object with an element-coded particle and identifying the object based on the element code are described. LIBS analysis can be used with the methods to provide a high resolution system for identifying and quantifying objects with great specificity. Objects can include biological and chemical molecules.... Agent: Delaware State University
20110171635 - Nucleic acid enzyme biosensors for ions: Disclosed are compositions and methods for the sensitive and selective detection of ions using nucleic acid enzymes.... Agent:
20110171642 - Analysing methylation specific pcr by amplicon melting: The present invention provides a method of evaluating DNA methylation in a sample. The method comprises (i) reacting the DNA with an agent that differentially modifies methylated cytosine and non-methylated cytosine to produce modified DNA, (ii) amplifying the modified DNA by methylation specific PCR to produce amplified DNA, and (iii)... Agent: Peter Maccallum Cancer Institute
20110171649 - Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v: Particular aspects provide nucleic acid detection methods comprising contacting a test sample having a nucleic acid target sequence with at least one endo-V-cleavable oligonucleotide probe complementary to the target sequence in the presence of an endonuclease V, incubating the reaction mixture under conditions suitable to support hybridization of the endo-V-cleavable... Agent:
20110171638 - Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a... Agent: Artemis Health, Inc.
20110171641 - Gene expression markers of recurrence risk in cancer patients after chemotherapy: The present invention relates to genes, the expression levels of which are correlated with likelihood of breast cancer recurrence in patients after tumor resection and chemotherapy.... Agent:
20110171650 - Gene expression related to preeclampsia: Gene expression patterns contemporaneous with early placental development in the first trimester of preeclamptic versus unaffected pregnancies have been obtained. Observation of differences in these gene expression patterns has allowed the identification of biomarkers that are useful in predicting and monitoring preeclampsia. These biomarkers are also useful in screening potential... Agent: University Of Florida Research Foundation, Inc.
20110171640 - Method for isolating cell free apoptotic or fetal nucleic acids: The present invention provides methods for isolating cell free nucleic acid, e.g., apoptotic or fetal nucleic acids and methods of detecting neoplastic cells or identifying the genetic composition of a fetus. The invention also provides magnetic particles comprising an anti-DNA antibody, and kits comprising the magnetic particles.... Agent: Novartis Vaccines And Diagnostics, Inc.
20110171647 - Method for quantifying or detecting dna: The present invention relates to a method for quantifying or detecting DNA having a target DNA region, and so on.... Agent: Sumitomo Chemical Company, Limited
20110171648 - Method of detecting and quantifying hepatitis c virus: Methods, reagents, and kits for detecting hepatitis C virus (HCV) in biological samples.... Agent: Abbott Laboratories
20110171643 - Method, process, and kit for cancer diagnosis, prognosis, and aftercare: The invention also relates to the pairs of amplification primers and/or a detection probe for the diagnosis/prognosis/follow-up of cancer including at least 15 nucleotide patterns of a nucleotide sequence selected from the SEQ ID nos. 1 to 6, and a kit including the said at least one pair of primers... Agent: Universite Jean Monnet
20110171637 - Methods and nucleic acids for analyses of cellular proliferative disorders: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among prostate cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for... Agent:
20110171645 - Methods of diagnosing acute cardiac allograft rejection: The present invention relates to methods of diagnosing acute rejection of a cardiac allograft using genomic expression profiling, proteomic expression profiling, metabolite profiling, or alloreactive T-cell genomic expression profiling,... Agent: The University Of British Columbia
20110171646 - Microrna expression profile associated with pancreatic cancer: Methods are provided for diagnosing whether a subject has, or is at risk of developing, pancreatic cancer. The methods include measuring the level of at least one miR gene product in a biological sample derived from the subject's pancreas. An alteration in the level of the miR gene product in... Agent: Board Of Regents Of The University Of Oklahoma
20110171644 - Multiplex capture of nucleic acids: Methods of capturing two or more nucleic acids simultaneously from a single sample are provided. Different nucleic acids are captured through cooperative hybridization events on different subsets of particles or at different selected positions on a spatially addressable solid support. Methods of capturing one or more long nucleic acids and... Agent: Affymetrix, Inc.
20110171639 - Polymer for detection of target substance, and method for detection of target substance: Provided is a method of detecting a target substance by which the target substance can be detected with efficiency and a high sensitivity, and in a simple manner, a target substance detection polymer used in the method, and a method of forming the polymer. The method of detecting a target... Agent: Eisai R&d Management Co., Ltd.
20110171654 - Allelic ladder loci: Disclosed are rare short tandem repeat (STR) alleles within the D10S1248 and D12S391 loci in humans. Provided are representative allelic ladders for each locus, methods and assays using these alleles and kits containing allelic ladders comprising these alleles for accurate genotyping and identification of a wide range of individuals.... Agent: Life Technologies Corporation
20110171652 - Cross primingamplification of target nucleic acids: Methods of amplifying target sequences by utilizing cross priming isothermal amplification are disclosed Methods of marking the amplification target sequence during the amplification reaction and rapid detection of the target sequence are also disclosed Reagent kits for rapid nucleic acid diagnosis and the nucleic acid detection of pathogenic microorganisms such... Agent:
20110171653 - Method for detecting cryptosporidium: A method for the detection and/or identification of Cryptosporidium organisms in general, and one or more of C. hominis, C. parvum and C. meleagridis organisms in particular and/or nucleic acid sequences and to hybridization assay probes, helper probes, amplification primers, nucleic acid compositions, probe mixes, methods and kits useful for... Agent: Sydney Water Corporation
20110171651 - Method for identifying a nucleic acid in a sample: A method of sample analysis is provided. In certain embodiments, the method may comprise: contacting a nucleic acid sample with a first primer and a second primer under PCR conditions to produce a double stranded product, wherein the second primer comprises a first label and is 5′ blocked; b) contacting... Agent: Agilent Technologies, Inc.
20110171656 - Method for normalizing the contents of biomolecules in a sample: The present invention relates to a method for normalizing the contents of biomolecules in a sample, comprising the following steps: a) preparing a reaction vessel with a vessel surface that is functionalized at least in sections—preferably on the inside of the vessel—in such a way that the surface can reversibly... Agent: Qiagen Gmbh
20110171658 - Method of quantifying polynucleotides using a stored calibration curve: Method for quantifying analyte polynucleotide in a test sample using real-time amplification and adjustment of a stored calibration curve. The method may be practiced using as few as a single adjustment calibrator to adjust the stored curve. This simplifies the quantitative analysis procedure, while still providing the advantages of internal... Agent: Gen-probe Incorporated
20110171655 - Ph measurement for sequencing of dna: The present method involves sequencing by synthesis in which a template strand having an attached primer is immobilized in a small volume reaction mixture. In one embodiment, the reaction mixture is in contact with a sensitive heat sensor, which detects the heat of reaction from incorporation of a complementary base... Agent: The Board Of Trustees Of The Leland Stanford Junior University
20110171657 - Process for predicting the prognosis of squamous cell lung cancer: Disclosed in this specification is a method for predicting the prognosis of squamous cell lung cancer by observing regulatory changes in select miRNA sequences. These sequences may include hsa-mir-146b, hsa-mir-191, hsa-mir-206, hsa-mir-299-3p, hsa-mir-155, hsa-mir-15a, hsa-mir-122a, hsa-mir-513, hsa-mir-184, hsa-mir-511, hsa-mir-100, hsa-mir-10a, hsa-mir-453, hsa-mir-379, hsa-mir-202, hsa-mir-21, hsa-mir-126, hsa-mir-494, hsa-mir-432, hsa-mir-370, and combinations... Agent:
20110171659 - Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof: The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are also provided.... Agent: Regents Of The University Of Minnesota
20110171660 - Use of ccr9, ccl25/teck, and integrin alpha4 in diagnosis and treatment of melanoma metastasis in the small intestine: The invention relates to methods for determining whether a melanoma will metastasize or has metastasized to the small intestine in a subject by detecting or quantifying the expression of the CCR9, CCL25/TECK, or integrin α4 gene. Also disclosed are methods for treating subjects so identified.... Agent:
20110171661 - Method for diagnosis of post-operative recurrence in patients with hepatocellular carcinoma: Provided are a method of diagnosing the recurrence or possibility of recurrence of hepatocellular carcinoma after hepatocellular carcinoma surgery and a method of screening a drug for preventing the recurrence of hepatocellular carcinoma after hepatocellular carcinoma surgery and treating hepatocellular carcinoma. Specifically, the recurrence or possibility of recurrence of hepatocellular... Agent:
20110171662 - Non-denaturing lysis reagent: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other... Agent: Abbott Laboratories
20110171663 - Microtrench and tumour proliferation assay: There is provided a cell culture microtrench being defined on or in a surface of a substrate, wherein the ratio of the width of the microtrench to the maximum length of the short axis of a cell type of interest is about 6 or preferably less, the length of the... Agent: University College Cardiff Consultants Ltd
20110171664 - Methods and reagents for detecting susceptibility to graft versus host disease or transplant related mortality: The present invention provides methods for determining the likelihood and/or severity of GvHD and the likelihood of the occurrence of transplant related mortality.... Agent:
20110171665 - P-selectin associated with eosinophils as a marker for asthma and correlating with b-1 integrin activation: Methods are provided for the detection of P-selectin associated with eosinophils and for the use of P-selectin as a biological marker for asthma. In one embodiment, the present invention relates to methods for detecting P-selectin in a sample containing eosinophils and quantifying the total number of eosinophils. In another embodiment,... Agent: Wisconsin Alumni Research Foundation
20110171666 - Peptide-lipid constructs and their use in diagnostic and therapeutic applications: Peptide-lipid constructs of the structure L-S—F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glycerolipid (including glycerophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG... Agent:
20110171667 - Reaction medium for detecting and/or identifying bacteria of the legionella genus: A reaction medium for the culture and/or detection and/or identification of bacteria of the Legionella genus includes at least one siliceous compound, where the siliceous compound is a nonpolar silica. A method for detecting and/or identifying bacteria of the Legionella genus, includes bringing a sample that may contain bacteria of... Agent: BiomÉ Rieux
20110171668 - Determination of equilibrium constants in solution by multi-step kinetics: The invention relates to a method for determining a first equilibrium constant of a first equilibrium reaction via MSK analysis of a second equilibrium reaction, whereby the first and the second equilibrium reaction share at least one reactant.... Agent:
20110171669 - Isolated luciferase gene of l. italica: The present invention relates to an isolated nucleic acid and polypeptide sequence that encodes for a luciferase of Luciola italica, as well as mutants thereof. The luciferase proteins of the present invention have been found to have extended bioluminescence emission that is red- or blue-shifted, and are useful as a... Agent:
20110171670 - Reagent open mechanism of luminescence measurement system and open needle control method in reagent open mechanism: A reagent open mechanism of the luminescence measurement system comprises a triaxial actuator and a reagent dispensing nozzle which is driven by the triaxial actuator. A reagent cartridge where a reagent to be divided by the reagent dispensing nozzle is filled in a concave and the opening of the concave... Agent:
20110171671 - Method for diagnosing acute cardiac ischemia: Chemiluminescent detection of metabolic by-products of inosine and hypoxanthine is used to diagnose ischemic events such as early acute cardiac ischemia.... Agent:
20110171672 - Method of reducing measurement error caused by catalase inhibition by azide: Disclosed is a method for reducing measurement errors due to inhibition of catalase by azide in a method for quantification of a component to be measured, in which hydrogen peroxide derived from a component other than the component to be measured is decomposed by a catalase. The method for reducing... Agent:
20110171674 - Beta-glucosidase variants having improved activity, and uses thereof: The present invention relates to the expression and optimization of enzymes involved in lignocellulosic biomass decomposition. The present invention relates more particularly to beta-glucosidase variants comprising at least one modification among the amino acids located at positions 225, 238, 240 and 241, according to the numbering in SEQ ID No.... Agent: Ifp Energies Nouvelles
20110171673 - Covalent tethering of functional groups to proteins and substrates therefor: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two... Agent:
20110171675 - Fret-based membrane-type 1 matrix metalloproteinase biosensor and methods for using the same: The present invention is a novel FRET-based biosensor composed of ECFP and YPet fluorescent proteins operably linked via a MT1-MMP recognition sequence for use in the detection of cancer cells in a biological sample.... Agent:
20110171676 - Asc as a marker for lung cancer: The present invention relates to the assessment of lung cancer. It discloses the use of protein ASC in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample, derived from an individual by measuring ASC in the sample. Measurement... Agent:
20110171680 - Buffy coat tube and float system and method: A tube and float system for use in separation and axial expansion of the buffy coat is provided. The system includes a transparent, or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The sample tube has an... Agent: Battelle Memorial Institute
20110171677 - Fluorescence detection of poison oak oil: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an... Agent:
20110171679 - L-glutamic acid-producing microorganism and a method for producing l-glutamic acid: A coryneform bacterium that is modified by using a yggB gene so that L-glutamic acid-producing ability is enhanced as compared to a non-modified strains is cultured in a medium to cause accumulation of L-glutamic acid in the medium or bacterial cells, and L-glutamic acid is collected from the medium or... Agent:
20110171681 - Methods and compositions for regulation of stem cell survival, proliferation, and differentiation by protein ubiquitination: Compositions and methods for regulating in vitro cell growth are disclosed, and for providing undifferentiated stem cells or embryonic cells that are suitable for transplantation into damaged tissues or organs, or for use in tissue repair. A representative method includes causing the overexpression or underexpression of GalT binding protein (GtBP),... Agent: Board Of Regents Of The University Of Texas System
20110171678 - Modified carbocyanine dyes and their conjugates: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein... Agent: Life Technologies Corporation
20110171682 - Screening methods employing insects with blood brain barrier: There is provided insect models that are aimed to reflect vertebrate blood-brain barrier (BBB) penetration. Investigation of BBB penetration is extremely important in drug discovery; successful CNS drugs have to cross the BBB, while BBB penetration may cause unwanted side effects for peripheral acting drugs. Specifically, the present invention relates... Agent: Entomopham Aps
20110171683 - Methods and compositions for enumerating antibiotic-resistant microorganisms: A thin film culture device for detection of antibiotic-resistant microorganisms is provided. The device can include indicators to differentiate staphylococcal from non-staphylococcal microorganisms. Methods of use include detecting or enumerating antibiotic-resistant microorganisms. The methods further include obtaining a differential count of staphylococcal and non-staphylococcal microorganisms.... Agent:
20110171684 - Inspection method of airborne floating bacteria and its apparatus: Inspection arrangements of airborne floating bacteria for performing a biological light emission reaction by using an ATP light emission reagent on the basis of the ATP derived from viable cells in captured airborne floating bacteria in the air contained in the inspection sample, measuring the light emission quantity due to... Agent: Hitachi Plant Technologies, Ltd.
20110171685 - Enzymatic hydrolysis of pretreated lignocellulose-containing material with paper mill sludge: A method for producing a fermentation product from a lignocellulose-containing material comprises pre-treating the lignocellulose-containing material; introducing paper mill sludge to the pre-treated lignocellulose-containing material; exposing the pre-treated lignocellulose-containing material to an effective amount of hydrolyzing enzyme; and adding a fermenting organism to produce a fermentation product. In an embodiment,... Agent: Novozymes North America Inc.
20110171686 - Reverse cumate repressor mutant: Recently, the development of inducible expression systems has involved exploitation of the p-cym operon from Pseudomonas putida. Disclosed herein are novel expression systems and components thereof, which involve the development of a CymR variant with reverse DNA binding activity, such that they exhibit increased affinity for DNA in a presence... Agent: National Research Council Of Canada
20110171687 - Unstructured recombinant polymers and compositions comprising same: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous... Agent: Amunix Operating, Inc.
20110171688 - Method of providing immunoglobulin secreting b lymphocytes and human antibodies: Provided is a method for producing a clone of an immortalized human B memory lymphocyte, comprising the step of inducing or enhancing telomerase activity in the B lymphocyte in the presence of a polyclonal B cell activator. The method is particularly useful in a method for producing a clone of... Agent:
20110171689 - Artificial immune system: methods for making and use: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates... Agent: Vaxdesign Corporation
20110171690 - Angiotensin converting enzyme inhibitory peptide: To provide ACE inhibitory peptides which can effectively inhibit ACE by a small amount of ingestion and have no fear of causing side effects and which can be orally ingested easily during daily life by persons having high blood pressure, and compositions comprising the peptides. The peptides represented by the... Agent: Kikkoman Corporation
20110171691 - Genetically modified strains for biotransformations in anthracycline production: A microbial strain which converts anthracycline metabolites into non-natural anthracycline antibiotics is described. A process for converting anthracycline metabolites into anthracycline antibiotics using a microbial strain is also described.... Agent: W.c. Heraeus Gmbh
20110171692 - Process for amplifying dna in cells: m
20110171693 - Amylases, nucleic acids encoding them and methods for making and using them: In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of starch... Agent: Verenium Corporation
20110171694 - Alpha-amylase mutants with altered properties: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered stability, in particular at high temperatures and/or at low pH relative, and/or low Ca2+ to the parent alpha-amylase.... Agent: Novozymes A/s
20110171695 - Alleles of the prpd1 gene from coryneform bacteria: An isolated mutant of coryneform bacteria comprising a gene encodes a polypeptide having 2-methylcitrate dehydratase activity, where the polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids except L-proline is present at position 272 or a corresponding or comparable position. In addition, an isolated polynucleotide... Agent: Evonik Degussa Gmbh
20110171696 - Biological synthesis of difunctional alkanes from carbohydrate feedstocks: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production... Agent: Celexion, LLC
20110171697 - Catalyzed preparation of (meth)acrylates of n-hydroxyalkylated amides: The claimed invention relates to a process for preparing (meth)acrylates of N-hydroxyalkylated amides, in which open-chain N-hydroxyalkylated amides are esterified with (meth)acrylic acid or transesterified with at least one (meth)acrylic ester in the presence of at least one heterogeneous catalyst selected from the group consisting of an inorganic salt and... Agent: Basf Aktiengesellshaft
20110171698 - C-22 hydroxylase: β-Amyrin, a precursor in biosynthesis of soyasapogenol B, is biosynthesized by cyclization of 2,3-oxidosqualene which is generated by the mevalonate pathway, and soyasapogenol B is biosynthesized by two hydroxylations of β-amyrin. However, a gene of 22-hydroxylase involved in the sequence of reactions has not been identified. The present inventors identified... Agent: Meiji Seika Kaisha, Ltd.
20110171700 - Method for producing l-phenylephrine using an alcohol dehydrogenase of aromatoleum aromaticum ebn1 (azoarcus sp. ebn1): The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2-methylamino-ethyl]-phenol.... Agent: Basf Se
20110171699 - Preparation of 6-aminocaproic acid from 5 -formyl valeri c acid: The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst. The invention further relates to a method for preparing e-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a... Agent:
20110171701 - Method for producing acrylamide: [Means for Solving] The present invention relates to a method for producing acrylamide by reacting acrylonitrile in the presence of a biocatalyst, wherein the reaction is performed using a reactor having a reaction volume of 1 m3 or more equipped with a tubular heat exchanger, and wherein the difference between... Agent: Dia-nitrix Co., Ltd.
20110171702 - Recombinant cell producing 2-hydroxyisobutyric acid: The invention relates to a cell which has been genetically modified so as to be capable of producing more 2-hydroxyisobutyric acid or more polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units than its wild type, characterized in that 2-hydroxyisobutyric acid or polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units are produced via acetoacetyl-coenzyme A... Agent: Evonik Roehm Gmbh
20110171703 - Bacterium capable of producing lactic acid, and method for producing lactic acid: The present invention provides: a lactic acid-producing Escherichia coli including an enzymatic activity of at least one NAD-dependent lactate dehydrogenase and an enzymatic activity of at least one NAD-independent lactate oxidoreductase, both of which are enhanced so as to decompose one of D-lactic acid or L-lactic acid and to produce... Agent: Mitsui Chemicals, Inc
20110171704 - Method for producing lactic acid from plant-derived raw material, and lactic-acid-producing bacterium: The present invention provides: a lactic acid-producing Escherichia coli comprising at least one gene of a sucrose non-PTS gene group, including at least a sucrose hydrolase gene, provided that a combination of a repressor protein (cscR), a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) and a... Agent: Mitsui Chemicals, Inc.
20110171705 - Process for the production of alcohol: The invention provides a process for the production of an alcohol which comprises cleaving polysaccharides in a cellulosic material in an aqueous medium at a temperature of at least 45° C. using a thermophilic microorganism to yield fermentable sugars, fermenting an aqueous solution of said sugars at a temperature of... Agent: Statoil Asa
20110171706 - Integrated process for production of alcohol from syngas and removal of co2: A process for producing alcohol from syngas integrates the alcohol recovery with the removal of CO2 from syngas. A syngas feed containing CO, H2, and CO2 contacts an aqueous alcohol stream to remove CO2 from the syngas that then passes to bioreactor containing microorganisms for conversion to alcohol and other... Agent:
20110171707 - Composition and methods for improving the production of fermentation operations: Methods and compositions for improving the production of ethanol by a microorganism in a fermentation medium are provided, where the method comprises adding to the fermentation medium an emulsion comprising a monoterpene and a surfactant in an amount sufficient to improve the production of ethanol.... Agent: Polymer Ventures, Inc.
20110171708 - Non-sterile fermentation of bioethanol.: A range of concentrations exists in which fermentation inhibitors derived from pretreatment of lignocellulosic feed stocks inhibit growth of lactic acid bacteria without affecting fermentive yeast. By optimizing levels of fermentation inhibitors to fall within this range, yeast fermentations of lignocellulosic biomass can be conducted under non-sterile conditions with ethanol... Agent:
20110171710 - Method for producing cellulosic ethanol: A method for producing cellulosic ethanol is disclosed, which comprises the following steps: adding the medium containing the source materials of cellulose and/or hemicellulose to fermentation reaction vessel; adding cellulase to fermentation reaction vessel, and inoculating Candida lusitaniae; running simultaneous saccharification fermentation (SSFs) with the combined action of cellulose and... Agent: Angelyeast Co., Ltd
20110171709 - Product recovery from fermentation of lignocellulosic biomass: The present invention is directed to a process of producing ethanol from lignocellulosic biomass, which comprises pre-treating a lignocellulosic feedstock to produce a reactive carbohydrate mixture; adding activated carbon in free form; converting said reactive carbohydrate mixture to form a beer; separating solids from said carbohydrate mixture or said beer... Agent: Mascoma Corporation
20110171711 - Methods and compositions for production of methane gas: The present invention provides methods and compositions for sustained methane production from atmospheric CO2 and solar energy from the sun. In general the methods involve culturing cyanobacteria in a first culture vessel and collecting and diverting the photosynthesis products, including glucose or acetic acid, to a second culture vessel including... Agent: The Regents Of The University Of California
20110171712 - Self-assembling tissue modules: e
20110171713 - Sorbent for a dialysis device: There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles.... Agent:
20110171715 - Biocompatible polymer and magnetic nanoparticle with biocompatibility: The invention discloses a biocompatible polymer for covalently modifying magnetic nanoparticles. The biocompatible polymer may be coupled to a targeting agent and/or a fluorescent dye. The invention also discloses a magnetic nanoparticle with biocompatibilities comprising the biocompatible polymer.... Agent: Industrial Technology Research Institute
20110171716 - Carbohydrate-based drug delivery polymers and conjugates thereof: Provided herein are water-soluble carbohydrate polymers which are monoderivatized at their reducing terminus, such that the carbohydrate polymers can be selectively conjugated at a single location. Also provided are methods of preparation and conjugation of the monoderivatized carbohydrate polymers.... Agent: Nektar Therapeutics
20110171714 - Crystal structure of tak1-tab1: The invention relates to molecules or molecular complexes which comprise binding pockets of TAK1 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising TAK1. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise... Agent: Vertex Pharmaceuticals Incorporated
20110171717 - Method for enhancing polymerase activity: A polymerase activity is effectively enhanced by adding an anionic surfactant, in particular an anionic surfactant having a polyethoxyl group, to a reaction mixture containing a polymerase.... Agent:
20110171718 - Proteases with modified pre-pro regions: The invention relates to modified polynucleotides encoding modified proteases, and methods for altering the production of proteases in microorganisms. In particular, the modified polynucleotides comprise one or more mutations that encode modified proteases having modifications of the pre-pro region that enhance the production of the active enzyme. The present invention... Agent: Danisco US Inc.
20110171719 - Prevention and remediation of petroleum reservoir souring and corrosion by treatment with virulent bacteriophage: Petroleum reservoir souring, caused by microbially induced production of hydrogen sulfide and other sulfur compounds, and the attendant corrosion are remediated by isolating bacteriophage(s) specific for the problematic bacteria (target bacteria) and adding an effective amount of such bacteriophage(s) to water introduced into or resident in the reservoir to kill... Agent:
20110171720 - Single-domain brain-targeting antibody fragments derived from llama antibodies: A phage-displayed library of llama single heavy domain antibodies (sdAbs) was enriched for species that selectively bind to and are internalized by human cerebromicrovascular endothelial cells (HCEC). From the enriched library, two sdAbs were selected, sequenced, subcloned, and expressed as fusion proteins with c-myc-His5 tags. Similarly as phage-displayed sdAbs, these... Agent: National Research Council Of Canada Nrc Communications & Corporate Relations
20110171721 - Targeted gene deletions for polysaccharide slime formers: The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene R Sphingomonas strains containing at least one genetic modification that favors slime-forming polysaccaride production. Methods of making the mutant Sphingomonas strains and the culture broth containing such mutant Sphingomonas strains are also provided.... Agent: Cp Kelco U.s., Inc.
20110171722 - Bacillus licheniformis and method for detoxification of zearalenone: The present invention discloses an isolated pure culture of a novel strain CK1 of Bacillus licheniformis, BCRC 910458, capable of detoxification of zearalenone (ZEN). Using physiological, biochemical, morphological identification and 16S rRNA gene sequence analysis methods, the strain CK1 was identified as Bacillus licheniformis. Through extracellular xylanase, CMCase protease assays... Agent: National Taiwan University
20110171723 - System and method for biogeochemical stabilization of chromate-impacted solids, including chromite ore processing residue (copr): The invention relates to a system and method for the substantially permanent biogeochemical stabilization of solids impacted with hexavalent chromium/Cr(VI), including chromite ore processing residue (“COPR”). The invention comprises a novel treatment method of adding amendment(s) to COPR or other chromate impacted solids for the purpose of (1) weathering COPR... Agent: Arcadis Corporate Services, Inc.
20110171724 - Apparatus and method for removing microbial contaminants from a flowing fluid: Methods and apparatuses for removing microbial contaminants from a flowing fluid in a cell culture incubator are disclosed. Some embodiments of the invention provide a cell culture incubator including a chamber, an airflow passage through which gasses circulate within the chamber, a filter configured to filter gasses that flow through... Agent:
20110171725 - Mechanism and method of preventing suction air from leaking during filtration of capturing carrier solution: A mechanism for preventing suction air from leaking uses a capturing carrier cartridge that includes a cartridge main body and a filter fixing ring. The cartridge main body includes a storage portion for storing a capturing carrier solution and a filter mounting portion where a filter for filtering the capturing... Agent:
20110171727 - Compositions and methods for activating genes of interest: Compositions and methods for activating genes of interest are provided. The compositions comprise a masked targeted expression cassette which expresses a gene product only in the presence of a target molecule. The cassettes are useful for the treatment of disease and for preventing the proliferation of neoplastic cells.... Agent:
20110171726 - Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same: Human adipose tissue-derived multipotent adult stem cells are provided, which are characterized by the ability to be maintained in an undifferentiated state for a long period of time by forming spheres and which have high proliferation rates. Also provided are methods for isolating and maintaining the adult stem cells, and... Agent: Rnl Bio Co. Ltd.
20110171728 - Method and composition for crystallizing g protein-coupled receptors: Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and... Agent:
20110171729 - Method for producing stable mammalian cell lines producing high levels of recombinant proteins: The invention provides a novel method for generating stable mammalian cell lines with enhanced protein production capabilities, and to expression vectors and related methods for high level expression of biopharmaceutical proteins of interest.... Agent: Ab Maxis Inc.
20110171730 - Conjugates for use in hepatocyte free uptake assays: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.... Agent: Isis Pharmaceuticals, Inc.
20110171731 - Compositions containing platelet contents: This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.... Agent:
20110171733 - Bovine immunodeficiency virus (biv) based vectors: BIV packaging constructs, BIV packaging cell lines, methods of making BIV packaging cells and methods of making BIV producer cells are described.... Agent: Novartis Ag
20110171734 - Conjugative plasmids and methods of use thereof: The present invention provides novel C. botulinum conjugatively transmissible plasmids and methods of use thereof. Specifically, described herein are novel, conjugatively transmissible clostridial plasmids which are capable of being transferred among and between clostridial species. The novel plasmids of the present invention therefore permits the delivery of heterologous clostridial genes... Agent: Wisconsin Alumni Research Foundation07/07/2011 > patent applications in patent subcategories.
20110165553 - Vitrified composition which preserves biological materials: The present invention relates to a method for preserving biological material comprising the steps of: providing a vitrification solution comprised of the biological material and a vitrification agent where the solution has a temperature in the range from 0.1° C. to 17.9° C.; microwaving the vitrification solution for a first... Agent:
20110165557 - Apparatus and method for detecting biomolecules: Provided are an apparatus and method for detecting biomolecules. The apparatus includes a FET having a substrate, a source electrode, a drain electrode, a channel region between the source and drain electrodes, and probe molecules fixed to the channel region, wherein the source and drain electrodes are separated on the... Agent: Electronics And Telecommunications Research Institute
20110165555 - Capillary-column-based bioseparator/bioreactor with an optical/electrochemical detector for detection of microbial pathogens: The present invention is directed to satisfying the need to detect microbial contamination of food products. The described bioseparator/bioreactor coupled with an optical/electrochemical biosensor was able to specifically detect E. coli O157:H7 from 8.8×101 to 8.8×106 CFU/ml in 2.5 hours without any enrichment. Using this invention, concentrations of S. Typhimurium... Agent: Board Of Trustees Of The University Of Arkansas
20110165558 - Method for identifying individual viruses in a sample: Individual viruses in any type of sample are identified quickly, unambiguously and reliably, and with the least possible preparation-related and technology-related expenditure, without necessitating immobilization using antibodies and without requiring an indication or at least a suspicion of potentially present viruses. This is accomplished by scanning the height profile of... Agent:
20110165554 - Methods and biomarkers for diagnosing and monitoring psychotic disorders: A method of diagnosing or monitoring a psychotic disorder, or predisposition thereto, comprises measuring, in a sample taken from a subject, the levels of one or more peptide biomarkers listed herein.... Agent: Cambridge Enterprise Limited
20110165556 - System and method for detection of hiv tropism variants: An embodiment of a method for detecting low frequency occurrence of one or more HIV sequence variants associated with drug resistance is described that comprises the steps of: generating cDNA species from each RNA molecule in an HIV sample population; amplifying at least one first amplicon from the cDNA species,... Agent: 454 Life Sciences Corporation
20110165563 - Design, synthesis and use of synthetic nucleotides comprising charge mass tags: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a... Agent: Quantumdx Group Limited
20110165561 - Direct and continuous root alone or root/shoot production from transgenic events derived from green regenerative tissues and its applications: The present invention provides assays and methods for efficiently testing a polynucleotide of interest for a phenotype in a root. In some embodiments, the assays and methods include regenerating green tissue that is transgenic for at least one polynucleotide of interest into one or more transgenic plantlets that have at... Agent: Pioneer Hi-bred International, Inc.
20110165559 - Lateral flow based methods and assays for rapid and inexpensive diagnostic tests: The invention provides reagents and methods for lateral flow assays and quantitative capture or determination of components, including cells, in a sample. In one aspect, reagents and methods for diagnostic assay are provided. In one embodiment an assay for determining T cell numbers, particularly a CD2+ CD4+ T cell assay... Agent:
20110165562 - Method for separating an analyte from a sample: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge... Agent:
20110165560 - Methods and compositions for screening for individuals at risk for succinate dehydrogenase-related disease conditions: The present invention provides methods, compositions, and kits associated with succinate dehydrogenase-related disease conditions. In one aspect of the present invention, a method for screening a test subject to determine risk for developing a succinate dehydrogenase-related disease condition is provided. Such a method can include obtaining a biological sample from... Agent:
20110165567 - Aberrant methylation of c6orf150 dna sequences in human colorectal cancer: This application describes methods and compositions for detecting and treating C6Orf150-associated neoplasia. Differential methylation of the C6Orf150 nucleotide sequences has been observed in C6Orf150-associated neoplasia such as colon neoplasia.... Agent:
20110165569 - Combinatorial dna taggants and methods of preparation and use thereof: DNA taggants in which the nucleotide sequences are defined according to combinatorial mathematical principles. Methods of defining nucleotide sequences of the combinatorial DNA taggants, and using such taggants for authentication and tracking and tracing an object or process are also disclosed.... Agent: Jeansee LLC
20110165565 - Compositions and methods for polynucleotide extraction and methylation detection: The present invention features methods and compositions for methylation detection, as well as a novel method for polynucleotide extraction and sodium bisulfite treatment.... Agent: The Johns Hopkins University
20110165571 - Herbicide tolerant rice plants and methods for identifying same: The invention provides specific transgenic rice plants, plant material and seeds, characterized in that these products harbor a specific transformation event at a specific location in the rice genome. Tools are also provided which allow rapid and unequivocal identification of the event in biological samples.... Agent: Bayer Bioscience N.v.
20110165570 - Method of effecting de-differentiation of a cell: The invention provides a method of effecting de-differentiation of an at least partially differentiated cell or of maintaining pluripotency and/or self-renewing characteristics of an undifferentiated cell. The method comprises increasing the amount or the activity of an Err protein, or a functional fragment thereof, in the cell.... Agent:
20110165572 - Methods and kits for nucleic acid sequencing: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.... Agent: Quantumdx Group Limited
20110165566 - Methods of optimizing treatment of breast cancer: Breast cancer treatment can be optimized by determining the level of expression of genes in a breast sample from a human to identify a human with an increased likelihood of recurrence of the breast cancer that would potentially benefit from a therapy to decrease the likelihood of recurrence of the... Agent:
20110165564 - Sequence-specific detection of methylation in biomolecules: A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a detectable cofactor of said methyltransferase; and (b) detecting whether the recognition sequence of said methyltransferase has been modified with the cofactor or a derivative thereof, wherein... Agent: Max-planck-gesellschaft Zur FÖ Rderung Der Wissenschaften E.v.
20110165568 - Sequences of e.coli 055:h7 genome: Disclosed is the genomic sequence for E. coli O55:H7 as well as compositions, methods, and kits for detecting, identifying and distinguishing E. coli O55:H7 from non-O55:H7 strains. In some embodiments, isolated nucleic acid compositions unique and/or specific to E. coli O55:H7 are described. Methods of detection and/or indentifying E. coli... Agent: Life Technologies Corporation
20110165576 - molecular diagnostic kit for the detection of virulent strains of helicobacter pylori: A kit in the form of a product and a method is able to detect simultaneously four genes of Helicobacter pylori (rDNA16S Hpy), i.e. one identification gene and three virulence genes (cagA, vacAm1, dupA). Moreover, the kit envisages the association of primers which determine the quality of extraction of the... Agent: Universidad De Concepcion
20110165574 - Method for amplifying specific nucleic acid fragments with the aid of a recurrent chain reaction: The invention relates to a method for amplifying specific nucleic acid fragments with the aid of two variants of a recurrent chain reaction 2/2 and 2/1, in which instead of the typical primers used in a standard PCR, the primers in the form of tandem repeated sequences of a singular... Agent: Institut Biokhimii I Genetiki Ufimskogo Nauchnogo Tsentra Ran
20110165575 - Method for synthesizing dna strand: The present invention provides a primer extension reaction method, such as a PCR method, for structure-independent amplification of DNA containing CG-rich repeat sequences wherein in the extension step the temperature fluctuates between a first extension temperature and a second extension temperature. The present invention also provides methods for diagnosing disorders.... Agent: Expression Analytics Oy
20110165573 - Method to detect prostate cancer in a sample: The present invention relates to prostate cancer. More specifically, the present invention relates to a method to detect prostate cancer in a patient sample by detecting the RNA encoded by the gene PCA3. More particularly the present invention relates to a method for determining a predisposition, or presence of prostate... Agent:
20110165578 - Methods for detecting and quantifying oversulfated glycosaminoglycans: The invention relates to novel methods for detecting and/or quantifying oversulfated or persulfated glycosaminoglycans based on inhibition of nucleic acid polymerases. The methods can be utilized to detect and quantify oversulfated or persulfated glycosaminoglycans in pharmaceutical preparations, such as heparin preparations or therapeutic medical devices. When used to detect or... Agent:
20110165579 - Pcr-ribotyping of c. difficile: Described is a method of polymerase chain reaction (PCR) analysis of polymorphisms in the 16s-23s intergenic spacer region of Clostridium difficile (“PCR ribotyping of Clostridium difficile”) comprising the use of a 16s primer corresponding to bases 1450 to 1501 of the 16s ribosomal RNA gene of C. difficile and a... Agent: Oster-reichische Agentur Fur Gesundheit Und Emahrungssichertheit Gmbh
20110165577 - Selection of colorectal cancer patients for neo-adjuvant and adjuvent systemic anti-cancer treatment: The present invention relates to method for determining whether a gastrointestinal cancer patient is likely to experience a disease recurrence, said method comprising steps of determining concentration of TIMP-1 in a pre-operative plasma sample of said patient, and determining the concentration of CEA in a pre-operative body fluid sample of... Agent:
20110165581 - Methods for screening for compounds for treating cancer: The methods described herein provide nucleic acid constructs and screening methods for identifying and validating compounds for use in the treatment of cancer, wherein the compounds down-regulate the post-transcriptional expression of Bmi-1.... Agent: Ptc Therapeutics, Inc.
20110165580 - Response element regions: Response element regions, DNA constructs comprising response element regions, host cells comprising response element regions, and methods of using response element regions are provided.... Agent: Amgen Inc.
20110165582 - Molecular method for diagnosis of colon cancer: Methods for diagnosing or detecting cancerous colon tissue. A panel of 17 specific marker genes are provided. The overexpression of some of these marker genes compared to their expression in normal human colon tissue and the underexpression of the rest of these marker genes are indicative of cancerous colon tissue.... Agent: National Research Council Of Canada
20110165583 - Vector for identification, selection and expression of recombinants: A modified vector comprising a reporter gene having a STOP codon upstream of the multiple cloning site of the vector which is characterized in that the recombinant clones show fluoresce or show color in presence of inducer. A method for identification and selection of recombinant clones comprising the modified vector... Agent: Lupin Limited
20110165584 - Variable lymphocyte receptors, related polypeptides and nucleic acids and uses thereof: Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs).... Agent: Benaroya Research Institute
20110165585 - Multi-species polynucleotide control sequences: The present invention relates to polynucleotide sequences which enable a polynucleotide control sequence, such as a promoter, to direct expression in a wide range of industrially relevant species, both prokaryotes and eukaryotes. When the polynucleotide sequences of the invention are applied in combination with selection marker genes it is possible... Agent:
20110165592 - Antibodies against human epo receptor: An antibody binding to human EPO receptor, characterized in specifically binding EPO receptor fragment LDKWLLPRNPPSEDLPGPGGSVDIV (SEQ ID NO:1), CSSALASKPSPEGASAASFEY (SEQ ID NO:2), or GGLSDGPYSNPYENSLIPAAEP (SEQ ID NO:3) is useful for the analysis of EPO receptor in human tissue.... Agent: Hoffman-la Roche. Inc.
20110165586 - Detection method of bio-chemical material using surface-enhanced raman scattering: Provided is a detection method of a biochemical material using surface-enhanced Raman scattering in order to detect the existence of a biochemical material in a target subject or its content therein, more particularly a detection method of a biochemical material facilitating multiplex detection with high-sensitivity, high-reproducibility, high-reliability, and high-precision owing... Agent: Korea Advanced Institute Of Science And Technology
20110165589 - Device and method for separating and analyzing blood: The invention provides a device for detecting FABP in a blood sample from a patient, methods for analyzing blood on the presence of FABP, as well as methods and kits for the detection of FABP in a blood sample from a patient.... Agent: Fabpulous B.v.
20110165587 - Method for live-cell activity assay: Provided are technologies capable of direct measurement of activity of a bioactive substance in cell using nanowires, more particularly, a method for measuring intracellular activity of a bioactive substance using a nanowire support to which cells are immobilized and a nanowire support to which target substances for the subject bioactive... Agent: Korea Institute Of Science And Technology
20110165588 - Method for quantifying phosphokinase activity on proteins: The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine... Agent: Life Technologies Corporation
20110165591 - Use of biglycan in the assessment of heart failure: The invention relates to a method for assessing heart failure in vitro and involves the steps of measuring in a sample the concentration of the marker biglycan, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by... Agent:
20110165590 - Vaccine protection assay: The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular N. meningitidis. The SBA assay is the most important method for measuring functional activity of serum antibodies against meningococcus. In order to determine whether a subject or a population is seropositive... Agent:
20110165595 - Apparatus and methods for processing a whole blood sample: The present invention provides a device and method for heating a whole blood sample for use in an assay, comprising irradiating said whole blood sample with monochromatic visible light of between 380 nm and 740 nm to raise the temperature of said whole blood sample to a target temperature between... Agent:
20110165596 - Use of carbamoyl phosphate synthetase 1 (cps) as a humoral biomarker for the diagnosis of tumour diseases and chronic inflammatory intestinal diseases: The invention relates to the use of carbamoyl synthetase 1 (CPS 1) as a humoral biomarker in in vitro methods for early diagnosis and detection, progress prognosis, the evaluation of the severity, and the progress evaluation of tumor diseases and chronic inflammatory intestinal diseases.... Agent: B.r.a.h.m.s Aktiengessellschaft.
20110165597 - method for the screening of conserved secreted proteins: Conserved polypeptides from protozoan parasitic species which are secreted through the endoplasmic reticulum/Golgi dependent secretory pathway, their identification and their use.... Agent: Institut De Recherche Pour Le Developpement (i.r.d.)
20110165593 - Mutants of 06-alkylguanine-dna alkyltransferase: The invention relates to AGT mutants showing, when compared to the wild type human AGT, two or more advantageous properties selected from (a) reduced DNA interaction; (b) localisation of the expressed protein in eukaryotic cells that is no longer restricted to the nucleus; (c) improved expression yield as soluble protein... Agent: Ecole Polytechnique Federale De Lausanne
20110165594 - Systemic markers for asthma and analogous diseases: Provided herein are diagnostic and prognostic methods, diagnostic and prognositic markers, and methods for evaluating anti-inflammatory agents or drugs in subjects with asthma and/or an analogous disease associated with high oxidative and nitrative stress at the disease site. In certain embodiments, the methods comprise a step of assaying for decreased... Agent: The Cleveland Clinic Foundation
20110165600 - Diagnosis method and diagnosis kit for dermatomyositis: An object of the present invention is to identify an antigen corresponding to anti-CADM-140 antibody, produce a recombinant protein, and establish an assay system by ELISA or the like. The present invention provides a kit for diagnosing dermatomyositis containing an MDA5 protein shown in SEQ ID NO: 4 or a... Agent:
20110165598 - Methods and compositions for treating alzheimer's disease: Aspects of the invention relate to methods and compositions for treating Alzheimer's disease (AD). In some embodiments, the invention provides methods for screening and identifying compounds that selectively inhibit the targeting of the insulin-Akt signaling pathway by Aβ oligomers.... Agent:
20110165599 - Monoclonal antibody therapy for pancreas cancer: The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively binding and co-specific antibodies and antibody fragments, in the treatment of pancreatic cancer.... Agent: Neogenix Oncology, Inc.
20110165601 - Assay system: The present invention relates to materials and methods for performing assays directed to monitoring activity and function of intracellular components, such as proteins associated with organelles and other intracellular structures. In particular, the invention relates to permeabilised cell preparations and their use in studying activity of intracellular components, in particular... Agent: The University Court Of The University Glasgow
20110165602 - Emission ratiometric indicators of phosphoinositides: Emission ratiometric indicators of phosphoinositides comprise a fusion protein comprising a pleckstrin homology (PH) domain of Akt (also known as protein kinase B) and a “pseudoligand” containing acidic amino acid residues, which is sandwiched between resonance energy transfer (RET) pairs, such as cyan and yellow mutants of GFP (a FRET... Agent: Johns Hopkins University
20110165603 - Small molecule fluorescent sensors for detection of post-translationalmodifications and protein interactions in bioassays: The present invention relates to novel compounds which are capable as acting as fluorescent sensors or which are precursors for these and for the use of these for the assay of biological processes such as posttranslational modifications of biological molecules such as phosphorylation, de-phosphorylation, proteolytic cleavage, phosphodiesterase mediated hydrolysis of... Agent: Gyrasol Technologies Inc.
20110165605 - Method for designing mutant enzyme, method for preparing mutant enzyme, and mutant enzyme: An object is to provide a novel method of improving an enzyme capable of deamidating a protein. A mutant enzyme is designed by the following steps: (1) specifying one or more amino acids selected from the following group, namely, consisting of an amino acid corresponding to the amino acid at... Agent: Amano Enzyme Inc.
20110165604 - Reaction medium for methicillin-resistant staphylococcus aureus (mrsa) bacteria: A reaction medium for detecting and/or identifying Methicillin-resistant Staphylococcus aureus (MRSA) bacteria, comprising a predetermined combination of two antibiotics, a first antibiotic which belongs to the cephalosporin family and a second antibiotic, said first and second antibiotics each being at a sub-inhibitory concentration.... Agent: Biomerieux
20110165606 - Methods for modifying, isolating, detecting, visualizing, and quantifying citrullinated and/or homocitrullinated peptides, polypeptides and proteins: The present invention relates to methods and compositions for modifying, isolating, detecting, visualizing, and quantifying citrulline and/or homocitrulline-containing peptides, polypeptides, and proteins using mono- and disubstituted glyoxal derivatives. The invention also provides kits for modifying, isolating, detecting, visualizing, and quantifying the relative amounts of citrulline and/or homocitrulline-containing peptides, polypeptides, or... Agent:
20110165607 - Method for evaluating status of skin barrier function of natural moisturizing factor using bleomycin hydrolase activity as indicator: The present invention provides a method for evaluating the status of the skin barrier function of natural moisturizing factor (NMF) using the activity of bleomycin hydrolase in skin tissue as an indicator.... Agent: Shiseido Company, Ltd.
20110165608 - Blood component measurement method utilizing hemolyzed whole blood, and kit for the method: The invention is a method for determining the concentration of an analyte in whole blood, wherein the analyte is a component which is contained in the blood, is different from a component occurring only in a red blood cell, and can generate hydrogen peroxide upon the reaction with an oxidase.... Agent: Nippon Kayaku Kabushiki Kaisha
20110165610 - Compositions, systems, and methods for preservation and/or stabilization of a cell and/or macromolecule: The present disclosure relates to compositions, systems, and methods for preserving and/or stabilizing a cell (e.g., a whole cell). A cell and/or macromolecule stabilizing composition may include a chelator, a chelator enhancing component, and optionally a base (e.g., a purine base or a pyrimidine base). A cell stabilizing method may... Agent:
20110165609 - Device, a system and a method for monitoring and/or cultivation of microscopic objects: The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during... Agent:
20110165611 - Dual modality detection of apoptosis: To image apoptosis in vivo, small, membrane-permeable probes comprising a caspase 3 substrate, a fluorogenic dye and a radionuclide is provided. This dual-modality probe can be cleaved by caspase upon exposure to apoptotic cells, allowing imaging of caspase 3 and 7 activities using both optical and nuclear imaging techniques. The... Agent:
20110165612 - Novel yeast strains for producing alcohol: The present invention relates to novel stable yeast strains, to a novel method for obtaining such strains, and to a novel method for evaluating the stability of a yeast strain. The present invention also relates to the yeasts obtained from these novel stable yeast strains, and to the use thereof... Agent:
20110165613 - Stable clone cell expressing a prion: The invention relates to a cell clone derived from the MovS6 line, said cell clone expressing a prion protein PrP and being capable of tolerating the replication or propagation of the pathological form PrPsc of said PrP, characterized in that its titre with respect to marker for infection with a... Agent: Institut National De La Recherche Agronomique
20110165614 - Reaction medium for staphylococcus aureus bacteria: A reaction medium for detecting and/or identifying Staphylococcus aureus bacteria, comprising a combination of two enzymatic substrates for alpha-glucosidase.... Agent: Biomerieux
20110165615 - Apparatus and methods for automated handling and embedding of tissue samples: An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports... Agent: Biopath Automation, L.L.C.
20110165616 - Method and apparatus for biopsy sample processing: A container for use in processing a biopsy sample. Biopsy sample and materials are received within a sample processing area of the container. A semi-permeable barrier is positioned at a downstream portion of the sample processing area and prevents the prevent passage of the biopsy sample. A cap is positioned... Agent: University Of Massachusetts
20110165617 - Enzymatic hydrolysis of pretreated lignocellulose-containing material with distillers dried grains: A method for producing a fermentation product from a lignocellulose-containing material comprises combining lignocellulose-containing material and distillers dried grains with or without solubles (DDG/S); pre-treating the combined ligno-cellulose-containing material and DDG/S; exposing the pre-treated combined lignocellulose-containing material and DDG/S to an effective amount of hydrolyzing enzyme; and fermenting with a... Agent: Novozymes North America, Inc.
20110165618 - Biological systems for production of commercially valuable compounds: The invention relates to systems and methods for production of compounds by yeast and other organisms. In one approach yeast engineered for production of a compound of commercial value is cultured together with a cellulosic bacteria, and the yeast uses a metabolic product produced by the bacteria as a carbon... Agent:
20110165620 - Method for the production of proteins or protein fragments: The present invention relates to a method for selecting a suitable expression construct from a plurality of expression constructs for optimizing the production of a protein or a fragment thereof in a host cell, a method for the production of proteins or fragment thereof using the selected expression vector, to... Agent:
20110165619 - Secretion optimized microorganism: Proteins having a cofactor can be secreted in an improved manner in a microorganism belonging to the genus Streptomyces provided that the microorganism contains a nucleic acid sequence which is not naturally present in it and which comprises at least the following sequence sections: a) nucleic acid sequence coding for... Agent:
20110165622 - Humanized anti-factor d antibodies and uses thereof: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies... Agent: Genentech, Inc.
20110165621 - Humanized antibodies: The invention relates to novel humanized antibodies derived from the conventional antibody repertoire of species in the family Camelidae.... Agent: Argen-x Bv
20110165623 - Compositions and methods for the high efficiency expression of the transforming growth factor-beta supergene family: Novel compositions and methods for the high efficiency production of the transforming growth factor-beta (TGFβ) supergene family of peptide growth factors are provided.... Agent: The Government Of The U.s. As Represented By The Secretary, Dept. Of Health & Human Services
20110165624 - Protein purification tags and uses thereof: The present invention relates to fusion proteins. In particular, the present invention relates to protein tags for use in protein solubilization and purification.... Agent: The Regents Of Theuniversity Of Michigan
20110165625 - Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic... Agent: Battelle Energy Alliance, LLC
20110165626 - High yield production of sialic acid (neu5ac) by fermentation: The present invention relates to a method for producing sialic acid, comprising the step of culturing a microorganism in a culture medium, wherein said microorganism comprises heterologous genes encoding a sialic acid synthase (NeuB), a UDP-GlcNAc epimerase (NeuC), said micro-organism being devoid of a gene encoding CMP-Neu5Ac synthase (NeuA) or... Agent: Centre National De La Recherche Scientifique (cnrs
20110165627 - Gene site saturation mutagenesis: A method for producing progeny polynucleotides and polypeptides by Gene Site Saturation Mutagenesis (GSSM). The method provides a set of degenerate primers corresponding to codons of a template polynucleotide, and performs polymerase elongation to produce progeny polynucleotides, which contain sequences corresponding to the degenerate primers. The progeny polynucleotides can be... Agent: Verenium Corporation
20110165628 - Thermocycling device: The present invention is related to a thermocycling device (10), comprising at least one sample holder (11), at least one thermal reference (12) and at least one heating and/or cooling device (13), which is arranged between said sample holder(s) and said thermal reference. Said heating and/or cooling device is in... Agent: Koninklijke Philips Electronics N.v.
20110165629 - Recombinase-based methods for producing expression vectors and compositions for use in practicing the same: Methods are provided for producing a vector that includes at least one splicable intron. In the subject methods, intron containing vectors are produced from donor and acceptor vectors that each include a site specific recombinase site, where the subject donor and acceptor vectors further include splice donor and acceptor sites... Agent: Life Technologies Corporation
20110165630 - Method of nucleic acid recombination: The invention provides a method for inserting a single stranded replacement nucleic acid into a target nucleic acid, said method comprising the steps of: a) generating a single stranded replacement nucleic acid from a double stranded nucleic acid, wherein the double stranded nucleic acid is adapted at one or both... Agent: Gene Bridges Gmbh
20110165631 - Arabinitol dehydrogenase from neurospora crassa: Stable and active arabinitol dehydrogenases (LAD) from Neurospora crassa and mutants thereof are disclosed. Arabinitol dehydrogenases are useful in the production of xylitol and ethanol from an arabinose containing substrate. Recombinant and heterologously expressed arabinitol dehydrogenases are useful in converting biomass into biofuels and other industrial food products.... Agent: Biotechnology Research And Development Corporation
20110165632 - Process for the preparation of an orexin receptor antagonist: The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.... Agent:
20110165633 - Production of polyketides and other natural products: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the... Agent:
20110165634 - Renewable chemical production from novel fatty acid feedstocks: Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, interesterification, hydroxylation, hydrolysis and saponification are disclosed. Novel oils containing fatty acid chain lengths of C8, C10, C12 or C14... Agent: Solazyme, Inc.
20110165635 - Methods and materials for processing a feedstock: The present disclosure relates generally to methods for processing a feedstock. Specifically, methods are provided for processing a feedstock by mixing the feedstock with an additive organism that comprises one or more transgenes coding for one or more enzymes. The expressed enzymes may be capable of breaking down cellulosic and... Agent: Chromatin, Inc.
20110165636 - Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester: The present invention relates to processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid salt and a process for the preparation of 3-(aminomethyl)-5-methylhexanoic acid. (S)-5-Methyl-3-nitromethyl-hexanoic acid or (R)-5-methyl-3-nitromethyl-hexanoic acid in enantioenriched form or enantiopure form as well as... Agent: Sandoz Ag
20110165637 - Fatty acid-producing hosts: Described are hosts for overproducing a fatty acid product such as a fatty acid. The hosts include an exogenous nucleic acid encoding a thioesterase and, optionally, an exogenous nucleic acid encoding an acetyl-CoA carboxylase, wherein an acyl-CoA synthetase in the hosts are functionally deleted. The hosts preferably include the nucleic... Agent:
20110165638 - Integrated bio-digestion facility: Methods and systems for processing organic waste material are provided. These methods and systems include integrating an anaerobic bio-digester and nutrient recovery module with a bio-production facility, which can locally provide feedstock for the bio-production facility, and can locally provide organic material for the anaerobic bio-digester. Methods and systems for... Agent: Highmark Renewables Research Limited Partnership
20110165639 - Refinery process to produce biofuels and bioenergy products from home and municipal solid waste: The present invention provides methods of a process (SOLWASFUEL system) for producing biofuel and bioenergy products using, as starting raw material, home and municipal organic solid waste, including recalcitrant lignocellulosic materials of paper, cardboards, organic plastics, cellulose plants, and food waste. In accordance with the invention, home and municipal solid... Agent: Brijen Biotech, LLC
20110165640 - Method for the enzymatic production of 2-hydroxy-2-methyl carboxylic acids: Provided is a composition containing: an isolated and purified polypeptide containing the amino acid sequence of SEQ ID NO: 4; and/or a heterodimeric enzyme containing: the isolated and purified polypeptide containing the amino acid sequence of SEQ ID NO: 4; and an isolated and purified polypeptide containing the amino acid... Agent: Evonik Roehm Gmbh
20110165641 - Synthesis of 1,2,4-butanetriol enantiomers from carbohydrates: A bioengineered synthesis scheme for the production of L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof from a carbon source is provided. Methods of producing L-1,2,4-butanetriol, D-1,2,4-butanetriol and racemic mixtures thereof are also provided. Methods are also provided for converting D-1,2,4-butanetriol and L-1,2,4,-butanetriol to D,L-1,2,4-butanetriol trinitrate.... Agent: The Board Of Trustees Of Michigan State University
20110165643 - Separation of lignin from hydrolyzate: A method for the production water insoluble reactive lignin having low sulfur content and lignosulfonates from lignocellulosic material in a batch or continuous process. Lignocellulosic material is fractionated to produce water insoluble native lignin and lignosulfonates in various ratios, while preserving the cellulose and hydrolyzed hemicelluloses using water, ethanol and... Agent:
20110165642 - Transformant of coryneform bacteria capable of producing isopropanol: m
20110165644 - Production of alkenes by enzymatic decarboxylation of 3-hydroxyalkanoic acids: The present invention relates to a method for generating alkenes biologically. It relates more particularly to a method for producing terminal alkenes by enzymatic decarboxylation of 3-hydroxyalkanoate molecules. The invention also relates to the enzymatic systems and the microbial strains used, and also to the products obtained.... Agent:
20110165645 - Methods using ion exchange and gel filtration chromatography for poxvirus purification: Provided herein are methods for purifying poxviruses using one or more chromatographic steps including, but not limited to, gel filtration and/or ion exchange chromatography.... Agent:
20110165646 - Super sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications: In on aspect, the invention includes a microcarrier bead having a porous three-dimensional core having (a) a polymeric porous three-dimensional body having porosity of about 15 to about 90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns, (b) an outer protective... Agent: Drexel University
20110165648 - Co-crystal structure of factor d and anti-factor d antibody: The present invention is directed towards the co-crystal structure of Factor D and an anti-Factor D antibody or an antigen binding fragment thereof.... Agent:
20110165650 - Fusion polypeptides capable of activating receptors: A fusion polypeptide comprising (A)x-M-(A)y, wherein A and A′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A′ may be each be an antibody or fragment derived from an antibody specific for a... Agent: Regeneron Pharmaceuticals, Inc.
20110165649 - Methods and compositions to improve the health of plants, animals and microbes by manipulating protein entry into symbionts and their hosts: Fusion constructs with i) a domain that is specific for binding, on the surface of a cell, a lipid that is characteristic of the cell, and ii) a domain or agent that possesses an activity of interest that impacts the cell, are provided. Binding of the fusion construct to the... Agent:
20110165647 - Nanoparticle conjugates: A nanoparticle conjugate comprising a nanoparticle having one or more peptide-ol compounds and one or more polyethylene glycol (PEG) compounds attached thereto. A method of producing the nanoparticle conjugate is also described.... Agent:
20110165652 - Compositions, methods and systems for single molecule sequencing: Compositions, systems and methods of sequencing are disclosed, where the compositions and systems include polymerase enzymes that have been genetically modified to more efficiently incorporate nucleotides including labels having a detectable properties that are released during incorporation, to augment a rate of labeled nucleotide incorporation, to augment a rate of... Agent: Life Technologies Corporation
20110165651 - High fidelity reverse transcriptases and the uses thereof: The invention relates to reverse transcriptases which have increased fidelity (or reduced misincorporation rate) and/or terminal deoxynucleotidyl transferase activity. In particular, the invention relates to a method of making such reverse transcriptases by modifying or mutating specified positions in the reverse transcriptases. The invention also relates to nucleic acid molecules... Agent: Life Technologies Corporation
20110165654 - Nucleic acid modifying enzymes: This invention provides for an improved generation of novel nucleic acid modifying enzymes. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytically modify the nucleic acid.... Agent: Bio-rad Laboratories, Inc.
20110165653 - Thymidine kinase mutants and fusion proteins having thymidine kinase and guanylate kinase activities: The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution located toward the N-terminus from a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as... Agent: Darwin Molecular Corporation
20110165655 - Lipolytic enzymes: The inventors have developed a method using protein engineering to produce lipolytic enzymes having a relatively high activity for one ester bond in an amphiphilic substrate with two lipophilic groups) and a relatively low activity for the ester bond in an amphiphilic substrate with one lipophilic group, e.g. a relatively... Agent: Novozymes A/s
20110165656 - Fungal transcriptional activators useful in methods for producing a polypeptide: The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which have transcriptional activity on a protease promoter, to PrtT proteins and to their use. The invention further relates to two distinct types of filamentous fungal cells. Filamentous fungal cells are transformed to over-express these PrtT proteins:... Agent: DsmIPAssets B.v.
20110165658 - Photosynthetic microorganisms enriched in selenium using selenohydroxy acid compounds, used thereof in nutrition, cosmetics and pharmacy: The invention relates to the enrichment of photosynthetic microorganisms in organic selenium using selenohydroxy acid compounds, in particular 2-hydroxy-4-methylselenobutanoic acid, in D or L form, or an enantiomer, salt or ester or amide derivative of these compounds, and also to the use of the microorganisms thus enriched in animal or... Agent: Eco Solution
20110165659 - Biological products: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the claims of the... Agent:
20110165660 - Engineered microorganisms with enhanced fermentation activity: Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms.... Agent: Verdezyne, Inc.
20110165661 - Engineered microorganisms with enhanced fermentation activity: Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms.... Agent: Verdezyne, Inc.
20110165662 - Method for harvesting microalgae suspended in an aqueous solution using a hydrophobic chemical: A process for harvesting microalgae from an aqueous suspension of microalgae is disclosed. A dilute aqueous suspension of the algae is mixed with a hydrophobic liquid with a specific gravity of less than 1 and, optionally, a flocculent. When the mixture settles, the microalgae become suspended in the hydrophobic liquid... Agent: Inventure Chemical, Inc.
20110165663 - Mist injector for gas treatment: A device and a method for producing a fine liquid mist and injecting the said mist into a gas stream to capture and remove very fine particulate pollutants. The pressurized gas stream is passed into a droplet generator (20) into which the liquid is sprayed and atomised into a mist... Agent:
20110165664 - Transfection device utilizing sericin: There is provided a transfection device having a mixture (1) immobilized on a solid-phase support (3), the mixture including: a gene sample; a gene delivery material; and at least one compound selected from the group consisting of sericin, a hydrolysate thereof and a chemically modified product of sericin or a... Agent: Cytopathfinder, Inc.
20110165665 - Apparatus and methods for detecting dna in biological samples: Apparatus and methods are described for detecting target DNA in a biological sample using capture probes and electrically-assisted hybridization. The reaction cell is formed with an attachment surface of aluminum oxide for better thermal and physical properties, and the aluminum oxide surface is coated with anti-DIG antibody to provide a... Agent: Hai Kang Life Corporation Limited
20110165666 - Photobioreactor: A photobioreactor comprising a receptacle with a first and a second outer side surface, wherein the receptacle is formed from a flexible, fluid-tight and transparent material, and wherein the receptacle is disposed in a rack provided with elongated, substantially vertical, support elements arranged in at least one horizontal row, whereby... Agent: Microa As
20110165667 - Method and system for converting electricity into alternative energy resources: A system to convert electric power into methane includes a reactor having a first chamber and a second chamber separated by a proton permeable barrier. The first chamber includes a passage between an inlet and an outlet containing at least a porous electrically conductive cathode, a culture comprising living methanogenic... Agent: The University Of Chicago
20110165669 - Anti-microrna oligonucleotide molecules: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.... Agent: Rockefeller University
20110165668 - Mhc class i peptide epitopes from the human 5t4 tumor-associated antigen: There is provided an MHC class I peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the amino acid sequence shown as SEQ ID NO: 2; (ii) the minimal epitope from the amino acid sequence shown as... Agent: Oxford Biomedica (uk) Limited
20110165672 - Buffy coat separator float system and method: A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced... Agent: Battelle Memorial Institute
20110165670 - Ketoreductases and uses thereof: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent: Codexis, Inc.
20110165671 - Process for providing an assembly of cell microcarriers: The present invention is related to a process for providing an assembly of cell microcarriers, comprising the steps of providing planar, two-dimensional objects having two sides (“flakes”), wherein these objects comprise a material which, upon application of an extrinsic stimulus, is transferred from the planar state into a rolled state,... Agent: Koninklijke Philips Electronics N.v.
20110165673 - Methods of culturing bacterial species of the anaplasmataceae family: The present invention relates to a method of culturing bacterial organisms belonging to the family Anaplasmataceae in mammalian embryonic or fetal cells. In particular, the present invention is directed to growth of bacterial organisms belonging to the family Anaplasmataceae including organisms belonging to the Anaplasma, Ehrlichia and Neorickettsia genera. The... Agent: Intervet International B.v.
20110165674 - Nk-1 receptor mediated delivery of agents to cells: Provided herein are conjugates including a targeting vehicle coupled to an agent. The targeting vehicle includes a tachykinin receptor ligand and a reactive moiety. Conjugates including a tachykinin receptor ligand attached to an antibody or fragment thereof that is specific for an intracellular target are also provided. Also provided are... Agent: The University Of Chicago
20110165675 - Capping bioprosthetic tissue to reduce calcification: A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to... Agent: Edwards Lifesciences Corporation
20110165676 - Method for decellularization: The present invention provides for decellularized tissue and method for decellularizing tissue. The method generally comprises the steps of obtaining a harvested tissue, performing a muscle shelf debridement, treating the tissue with an enzyme, washing the tissue with a detergent, and performing an organic solvent extraction on the tissue. The... Agent: The Children's Mercy Hospital
20110165677 - Method for reducing deposits during the cultivation of organisms: The invention relates to a process for reducing the amount of deposits during the culture of organisms, and in particular of cell cultures, where these have a tendency towards agglomeration or adhesion to the bioreactor and to its elements, or where these are readily susceptible to agglomeration or adhesion of... Agent: Bayer Technology Services Gmbh
20110165678 - New tomato ethylene response factors and uses thereof: e
20110165679 - Methods and compositions for targeted polynucleotide modification: A variety of methods and compostions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism, methods for integrating polynucleotides of interest, methods to assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the... Agent: Pioneer Hi-bred International, Inc.
20110165680 - Clean genome bactofection: Methods for introducing and expressing genes in animal cells are provided comprising infecting the animal cells with live invasive reduced-genome bacteria comprising a eukaryotic expression cassette comprising said gene. Also provided are methods for producing a pluripotent stem (iPS) cell from a mammalian somatic cell comprising infecting the somatic cell... Agent: Scarab Genomics, LLC
20110165682 - Human trophoblast stem cells and use thereof: Existence of human trophoblast stem (hTS) cells has been suspected but unproved. The isolation of hTS cells is reported in the early stage of chorionic villi by expressions of FGF4, FGFR-2, Oct4, Thy-1, and stage-specific embryonic antigens distributed in different compartments of the cell. hTS cells are able to derive... Agent:
20110165681 - Light-activated proton pumps and applications thereof: In a method for adjusting the voltage potential or pH of, or cause proton release from, cells, subcellular regions, or extracellular regions, a gene encoding for a light-driven proton pump is incorporated into at least one target cell or region, the proton pump operating in response to a specific wavelength... Agent: Massachusetts Institute Of Technology
20110165683 - Chimeric gammaretrovirus: The invention is directed to a chimeric gammaretrovirus comprising an gammaretroviral virion which contains a lentiviral Vpx protein and methods of use thereof.... Agent: University Of MassachusettsPrevious industry: Education and demonstration
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