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Chemistry: molecular biology and microbiology June invention type 06/11

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
06/30/2011 > patent applications in patent subcategories. invention type

20110159474 - Solutions for perfusing and preserving organs and tissues: The present invention relates to solutions which are suitable for the perfusion and preservation of organs, organ parts, tissues or tissue parts of human or animal origin. The solutions suitable for this contain at least one active agent, which is selected from the group of NO-independent stimulators and activators of... Agent: Bayer Schering Pharma Aktiengesellschaft

20110159475 - Integrated bio-reactor monitor and control system: Systems and methods for automatically controlling conditions of a process are disclosed. In one example, a controller is programmed with a sequence of steps and parameters required to carry out a bioreactor process. The controller receives information related to a condition of the process over a first communication network, determines... Agent: Broadley-james Corporation

20110159476 - Methods and apparatus for characterizing polymeric mixtures: The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental measurements of a polymeric mixture of interest. The elimination step can be repeated one or more times using different experimental measurements produced by various... Agent:

20110159477 - Products and analytical method: The present invention describes product and analysis method for analysis of a substance, a virus, a bacteria or a cell which binds to carbohydrate structures. One or more carbohydrates, or carbohydrate derivatives, is bound to spherical or non-spherical polymer beads (for example microspheres or nanospheres). Formed carbohydrate-polymer beads or carbohydrate-polymer... Agent:

20110159484 - Apparatus and method of authenticating product using polynucleotides: A method of authenticating a product includes; hybridizing a target polynucleotide which is associated with the product and which includes a first target region and a second target region adjacent to the first target region with a probe polynucleotide that comprises a first segment having a nucleotide sequence completely complementary... Agent: Samsung Electronics Co., Ltd.

20110159480 - Cell-based screening assay to identify molecules that stimulate ifn-alpha/beta target genes: A method using cells transformed with a construct containing a reporter gene operatively-linked to an interferon stimulated response element for identifying an agent, such as a chemical compound, peptide or polypeptide, which exhibits an interferon-like activity on the interferon stimulated response element (ISRE) and modulates genes activated by activation of... Agent: Institut Pasteur

20110159483 - Cyanine compounds, compositions including these compounds and their use in cell analysis: A compound having the general formula I or a conjugate thereof, wherein various groups are as defined in the specification. A composition includes: (i) a compound having the general formula I or a conjugate thereof; and (ii) at least one surfactant selected from cationic surfactants and nonionic surfactants. Also disclosed... Agent: Shenzhen Mindray Bio-medical Electronics Co., Ltd.

20110159479 - Genetic polymorphisms in the cytochrome p450 gene with clopidogrel resistance: The present invention relates to a method for predicting the resistance of a human subject to clopidogrel, which comprises detecting the presence or absence of a A allele at position 636 of exon 4 in the CYP2C19 gene, wherein the presence of the A allele is indicative of a clopidogrel... Agent: Industry-university Cooperation Foundation Yonsei University

20110159482 - Method for detecting multiple small nucleic acids: The present invention discloses a method for simultaneously detecting multiple small nucleic acids, which comprises steps: mixing a specimen, fluorescent probes, and bridge nucleic acids having different lengths to form a tested liquid; hybridizing the mixed short nucleic acid molecules, probes and bridge nucleic acids; adding ligases to enable the... Agent:

20110159478 - Method for screening drug candidates by using domain protein: The present invention relates to a method for screening and discovering bioactive materials using specifically selected protein domains interacting with specific intracellular proteins, and more particularly, to (1) a screening method including confirmation of changes in biological activities by introducing a specific protein domain into microorganisms or animal and plant... Agent: Korea Research Institute Of Standards And Science

20110159481 - Solid-phase chelators and electronic biosensors: Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a... Agent:

20110159486 - Cell cycle switch 52(ccs52) and methods for increasing yield: Methods and compositions for modulating plant yield are provided. Methods include employing cell cycle switch 52 (ccs52). The ccs52 sequences are used in a variety of methods including modulating plant biomass, growth, or both. Transformed plants, plant cell, tissues, seed, and expression vectors are also provided.... Agent: Pioneer Hi-bred International, Inc.

20110159487 - Identification of a gene expression profile that differentiates ischemic and nonischemic cardiomyopathy: A method of preparing a gene expression prediction profile for distinguishing ischemic and nonischemic cardiomyopathy comprises the steps of obtaining clinical specimens from patients suffering from ischemic or nonischemic cardiomyopathy, isolating nucleic acid sequences from at least a plurality of said specimens, obtaining a gene expression level corresponding to each... Agent:

20110159485 - Lysis buffers for extracting nucleic acids: The present teachings relate to the extraction of nucleic acid from solid materials. Provided are useful compositions, methods and kits for obtaining nucleic acids from a solid biological sample or an adhesive material having a biological material adherent or embedded within the adhesive substrate. The extracted nucleic acid can be... Agent: Life Technologies Corporation

20110159494 - Analyzing the fmr1 gene: A method of predicting a degree of risk of autoimmunity in a human female is disclosed. The method may include analyzing the female's FMR1 gene, wherein the FMR1 gene has a first allele and a second allele, determining the number of triple CGG repeats on each of the first and... Agent:

20110159493 - Diagnostic polymorphisms for cardiac disease: One or more polymorphisms, including single nucleotide polymorphisms (SNPs), or combinations thereof, for diagnosis of cardiac disease, such as heart failure and atrial fibrillation.... Agent:

20110159492 - Diffuse large b-cell lymphoma markers and uses therefore: The present invention provides methods and compositions for prognosing treatment outcome in DLBCL patients, diagnosing DLBCL and monitoring efficacy of DLBCL treatment.... Agent:

20110159491 - Method for detecting cytosine methylation in dna samples: Described is a method for detecting 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, 5-methylcytosine and cytosine reacting differently, and the pretreated DNA is subsequently amplified using a polymerase and at least one primer. In the next step, the... Agent:

20110159495 - Method for the quantitative detection of an organic substance in a sample: A method for the quantitative detection of an organic substance containing a nucleic acid to be detected in a sample based on a given threshold value for that organic substance in the sample, the use of this method, as well as a kit for practicing this method.... Agent:

20110159488 - Primers for amplification and sequencing of eubacterial 16s rdna for identification: The invention relates to oligonucleotides for the qualitative and/or quantitative amplification and/or the sequencing of 16S rDNA-genes, as well as of fragments thereof and RNA derived thereof. It relates to their use as primers in amplification reactions and in sequencing, in particular in combination for the identification of the genus/species/strain... Agent: Smartgene Gmbh

20110159489 - Single nucleotide polymorphisms associated with dietary weight loss: The present invention relates to genetic polymorphisms associated with obesity and obesity-related phenotypes and their use in predicting if an individual successfully completes a dietary weight loss intervention program.... Agent: DsmIPAssets B.v.

20110159490 - Use of the combing process for the identification of dna origins of replication: Eukaryotic genomes are duplicated by the activation of multiple bidirectional origins of replication. The replication programs of these cells depend on the temporal and spatial organisation of replication origins throughout the genome. To investigate the replication program in a higher eukaryote, we employed a technique called molecular combing. This technique... Agent: Institut Pasteur And Centre National De La Recherche Scientifique (cnrs)

20110159505 - method of manufacturing a mixture of amplified double-stranded nucleic acids comprising unknown sequence: A method of manufacturing a mixture of amplified double-stranded nucleic acids comprising: (a) preparing a single-stranded nucleic acid comprising a single-stranded adapter 1, a single-stranded nucleic acid fragment and a single-stranded adapter 2, and (b) conducting PCR with said single-stranded nucleic acid prepared in step (a), a primer 1, and... Agent: Riken

20110159500 - Compositions including ginger for the amelioration or prevention of inflammatory conditions: The invention encompasses a method for diagnosing an arthritic condition and a gastrointestinal inflammatory disorder in a companion animal. The invention also encompasses a method for identifying ingredients for a pet food composition that are suitable for preventing, ameliorating the symptoms of, or treating an arthritic condition or gastrointestinal inflammatory... Agent: Hill's Pet Nutrition, Inc.

20110159503 - Dna extraction method for bursaphelenchus xylophilus from wood chips, lamp primer set for bursaphelenchus xylophilus, and detection method for bursaphelenchus xylophilus from wood chips: To extract and detect Bursaphelenchus xylophilus DNA without isolating Bursaphelenchus xylophilus from a piece of wood taken from a tree belonging to the genus Pinus and the like, provided are a method for extracting Bursaphelenchus xylophilus DNA from a collected piece of wood that includes Bursaphelenchus xylophilus, a LAMP primer... Agent: Forestry And Forest Products Research Institute

20110159497 - Freeze-dried compositions for carrying out pcr and other biochemical reactions: A composition for carrying out a chemical or biochemical reaction, said composition being in a freeze-dried form and comprising (i) a set of reagents comprising at least some of the chemical or biochemical reagents necessary for conducting said chemical or biochemical reaction, (ii) a glass forming agent, (iii) a stabilising... Agent: Enigma Diagnostics Limited

20110159499 - Methods and compositions for detecting genetic material: This invention provides compositions and methods for detecting differences in copy number of a target polynucleotide. In some cases, the methods and compositions provided herein are useful for diagnosis of fetal genetic abnormalities, when the starting sample is maternal tissue (e.g., blood, plasma). The methods and materials described apply techniques... Agent: Quantalife, Inc.

20110159498 - Methods, agents and kits for the detection of cancer: The present invention relates to methods of diagnosing a cancer in a subject, and methods of providing a prognosis for a subject that has a cancer. The invention also relates to diagnostic and prognostic kits for cancer.... Agent: China Synthetic Rubber Corporation

20110159504 - Methylation markers for sensitivity to microtube based therapies and methods of use: The present invention relates to the use of nucleic acid methylation and methylation profiles to detect predict sensitivity of cells to cytotoxic chemotherapies, and in particular to microtubule based therapies, for example taxanes. The invention relates to methods for identifying a methylation profile of the checkpoint with forkhead and ring... Agent: The Johns Hopkins University

20110159496 - Molecular diagnosis and classification of malignant melanoma: The present invention provides methods for diagnosing and providing a prognosis of melanoma using molecular markers that are overexpressed in melanoma cells. The invention provides kits for diagnosis and prognosis. Also provided are methods to identify compounds that are useful for the treatment or prevention of melanoma and melanoma progression.... Agent: The Regents Of The University Of California

20110159501 - Use of methylated or unmethylated line-1 dna as a cancer marker: The invention relates to a method of detecting LINE-1 (long interspersed nucleotide elements-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-1 DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression... Agent:

20110159502 - Use of methylated or unmethylated line-1 dna as a cancer marker: The invention relates to a method of detecting LINE-1 (long interspersed nucleotide elements-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-1 DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression... Agent:

20110159507 - Method for detecting the drug effects of dna methylation-inhibitors: Disclosed is a method for detecting the drug effects of DNA methylation inhibitors that detects the drug sensitivity of gene-expressing cells to DNA methylation inhibitors based on gene expression of a transcription factor (PU. 1) and/or gene expression of metallothionein (MT) that participates in differentiation to neutrophil and monocyte lines... Agent: School Juridical Person The Kitasato Institute

20110159506 - Methods for assessing rna patterns: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.... Agent: Caris Life Sciences Luxembourg Holdings

20110159508 - Gfats as modifiers of the p53 pathway and methods of use: Human GFAT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of GFAT are provided.... Agent: Exelixis, Inc.

20110159510 - Use of methylated or unmethylated line-1 dna as a cancer marker: The invention relates to a method of detecting LINE-1 (long interspersed nucleotide elements-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-1 DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression... Agent:

20110159509 - Use of runx3 and mir-532-5p as cancer markers and therapeutic targets: The invention relates to methods for cancer diagnosis, prognosis, and treatment based on the expression or activity levels of RUNX3 and miR-532-5p. Also disclosed is a method of reducing the inhibition of RUNX3 by miR-532-5p with an agent that interferes with the interaction between RUNX3 and miR-532-5p transcripts.... Agent:

20110159511 - Microfluidic device screening method: The invention provides methods of screening a microbial host cell for a property of interest in a microfluidic device, the method comprising the steps of: a) transforming a d-alanine racemase-deficient microbial host cell with a polynucleotide construct comprising: i) one or more polynucleotide region providing the property of interest when... Agent:

20110159512 - Polynucleotide sequences of candida dubliniensis and probes for detection: The present invention relates to identification of centromeric sequences of Candida dubliniensis and localization of CdCse4p centromeric histone to the identified region. Also the present invention relates to distinguishing Candida dubliniensis from other members of genus Candida.... Agent: Jawaharlal Nehru Centre For Advanced Scientific Research

20110159513 - Methods and systems for predicting response of cells to a therapeutic agent: The invention provides methods for treating patients which methods comprise methods for predicting responses of cells, such as tumor cells, to treatment with therapeutic agents. These methods involve measuring, in a sample of the cells, levels of one or more components of a cellular network and then computing a Network... Agent: Merrimack Pharmaceuticals, Inc.

20110159514 - Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereof: The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has applications in the diagnosis of osteoarthritis and/or other ageing-related diseases, in determining the prognosis for an individual diagnosed with osteoarthritis and/or other ageing-related... Agent:

20110159515 - Compositions and methods for the rapid growth and detection of microorganisms: The invention relates to assay methods for use in detecting specific materials such as core oligosaccharides derived from microorganisms, particularly pathogenic microorganisms, in a test sample. The invention further relates to compositions and methods for the rapid growth of such microorganisms enabling detection of same significantly earlier than is currently... Agent: Solus Scientific Solutions Limited

20110159518 - Method for the diagnosis of the presence of an ovarian cancer: The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of... Agent: National Health Research Institute

20110159516 - Pcan065 antibody compositions and methods of use: The invention provides isolated anti-PCan065 antibodies that bind to PCan065. The invention also encompasses compositions comprising an anti-PCan065 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PCan065 antibody, as... Agent: Diadexus, Inc.

20110159517 - Zinc binding compounds and their method of use: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of zinc ions in a sample. The metal chelating moiety of the zinc-binding compound is an analog of the well-known calcium chelator, BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid), wherein the chelating moiety has been modified from a... Agent: Life Technologies Corporation

20110159520 - Hybrid proteins comprising membrane receptor and ion channel, and their use as biosensors: The present invention relates to the use of a hybrid protein including the sequence of a first membrane receptor fused at its C-terminus to the N-terminus of an ion channel, and possibly containing a linker between the C-terminus of the first membrane receptor and the N-terminus part of the ion... Agent: Universite Joseph Fourier

20110159519 - Optical biosensors: Provided are biosensors, compositions comprising biosensors, and methods of using biosensors in living cells and organisms. The biosensors are able to be selectively targeted to certain regions or structures within a cell. The biosensors may provide a signal when the biosensor is targeted and/or in response to a property of... Agent: Carnegie Mellon University

20110159522 - Three-dimensional microfluidic platforms and methods of use thereof: Provided are methods and devices for formation and study of three-dimensional biological systems, including prokaryotic and eukaryotic cell migration, proliferation, and differentiation.... Agent:

20110159521 - Methods for diagnosing irritable bowel syndrome: The invention provides an ELISA assay for the determination of serum mast cell β-tryptase levels using rabbit anti-tryptase as the capture antibody and alkaline phosphatase conjugated G3 as the detecting antibody. Luminescent substrate CPSD was used to enhance the assay sensitivity. Also provided are methods for aiding in the diagnosis... Agent: Prometheus Laboratories Inc.

20110159524 - Method for monitoring hydrolytic activity: The present invention relates to methods of measuring the activity of a hydrolytic agent comprising contacting a biomolecule with a hydrolytic agent in the presence of a fluorescent dye under conditions that allow digestion of the biomolecule by the hydrolytic agent. The fluorescence of the dye is monitored over time... Agent: Fluorotechnics Pty Limited

20110159525 - Methods to determine immunogenicity of humanized anti-tag 72 cc49 antibodies: The present disclosure provides humanized CC49 monoclonal antibodies that bind TAG-72 with high binding affinity and that are minimally immunogenic. In one embodiment, a humanized CC49 antibody includes a non-conservative amino acid substitution in a light chain complementarity determining region 3 of the CC49 antibody. In a further embodiment, the... Agent: The U.s.a, As Represented By The Secretary, Department Of Health And Human Services

20110159523 - N-terminal specific chemical labeling for proteomics applications: Described herein is a method that may be used in various applications, such as drug development, medical diognosis and gene/protein therapy. In one embodiment, the subject matter discloses an effective method for identification and quantification of large sets of proteins/peptides in vitro and cells in vivo.... Agent: Cedars-sinai Medical Center

20110159527 - Methods and kits for diagnosing neurodegenerative disease: Methods and diagnostic kits for determining whether a subject may develop a or for diagnosing a neurodegenerative disease. The method includes quantitating the amount of alpha-synuclein and total protein in a cerebrospinal fluid (CSF) sample obtained from the subject and calculating a ratio of alpha-synuclein to total protein content; comparing... Agent:

20110159528 - Methods and materials for the detection of leishmania infection: The present invention provides rapid diagnostic assays for the detection of Leishmania which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive assays, including ELISA and lateral flow assays, employ antibodies that may be effectively employed to detect the Leishmania major antigen... Agent: Inbios International, Inc.

20110159526 - Methods for prdicting pregnancy outcome in a subject by hcg assay: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin... Agent: The Trustees Of Columbia University In The City Of New York

20110159529 - Fusion protein having luminescence activity: The fusion protein comprising (1) a first region comprising the amino acid sequence of SEQ ID NO: 18 and (2) a second region comprising an amino acid sequence for a polypeptide containing at least one cysteine residue for binding to other useful compound via the thiol group can be modified... Agent: Chisso Corporation

20110159530 - Methods of quantifying biomarkers: Methods are provided for simultaneously measuring hematocrit (hct) level and the concentration of a biomarker in a blood specimen. Thus, serum biomarker concentrations can be more accurately measured. The methods are particularly useful for newborn screening programs.... Agent: Health Research, Inc.

20110159533 - Bioparticle capture device, and use thereof: t

20110159532 - Gef-h1b: biomarkers, complexes, assays and therapeutic uses thereof: The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.... Agent: Sugen, Inc.

20110159531 - Method and apparatus for measuring amount of substance: Disclosed herein are a method and apparatus for measuring an enzyme amount. The measurement of the enzyme amount is carried out by measuring a transmittance of a reaction mixture containing the enzyme and its substrate over the reaction time period and providing an optical characteristic curve, dividing the optical characteristic... Agent: Samsung Electronics Co., Ltd.

20110159536 - Device for capturing object and method for using the same: An object of the present invention is to provide an object-capturing device which accurately detects objects such as microorganisms captured at a test site. The object-capturing device of the present invention includes a capturing dish holding a carrier, which captures objects (microorganisms), on a first side of the capturing dish.... Agent: Hitachi Plant Technologies, Ltd.

20110159534 - Method and culture medium for enhanced detection of mycobacterium: The present invention relates to an improved culture medium and method for the enhanced growth and detection of Mycobacterium growth. The invention further relates to an improved mycobacterial reagent system or kit that can be used for the enhanced growth and detection of Mycobacterium.... Agent: Biomerieux, Inc.

20110159535 - Preparation and use of nucleated red blood cell simulating particles and hematology control mixtures: The present disclosure provides a nucleated red blood cell simulating particle, which may be leukocytes bound to a fluorescent-staining inhibitor capable of stably binding to the nucleus or a nucleic acid in a cell so as to reduce the binding capacity of the particles to a fluorescent dye during their... Agent: Shenzhen Mindray Bio-medical Electronics Co. Ltd.

20110159538 - Process for preparation of insulin compounds: The present invention relates to the preparation of insulin compounds including their analogs or derivatives thereof from their corresponding precursor forms by a one step enzymatic reaction involving the combinatorial and concurrent use of optimal quantities of trypsin and carboxypeptidase B that work synergistically directing the reaction in a controlled... Agent: Biocon Limited

20110159537 - Synthetic pathway enzymes for the production of argyrins: The invention provides the amino acid sequences comprised in or constituting the synthetic pathway enzymes participating in the production of Argyrins, as well as the nucleic acid sequences encoding the synthetic pathway enzymes participating in the production of Argyrins, as well as genetically manipulated micro-organisms containing nucleic acid sequences encoding... Agent: Helmholtz-zentrum Fur Infektionsforchung Gmbh

20110159539 - Method for producing recombinant proteins with a constant content of pco2 in the medium: A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polypeptide, wherein the content of dissolved CO2 (pCO2)... Agent:

20110159541 - Methods and compositions for inactivating alpha 1,6 fucosyltransferase (fut8) gene expression: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.... Agent: Sangamo Biosciences, Inc.

20110159540 - Methods for chemically synthesizing immunoglobulin chimeric proteins: The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule.... Agent:

20110159542 - Immunosuppressive polypeptides and nucleic acids: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.... Agent: Perseid Therapeutics LLC

20110159543 - Scalable process for culturing per.c6 cells and producing products therefrom: The invention provides methods for culturing adherent PER.C6 cells and producing products therefrom.... Agent:

20110159545 - Fungamyl-like alpha-amylase variants: The invention relates to a variant of a parent Fungamyl-like fungal alpha-amylase, which exhibits improved thermal stability at acidic pH suitable for, e.g., starch processes.... Agent: Novozymes A/s

20110159544 - Method for treating cellulosic material and cbhii/cel6a enzymes useful therein: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used, for example for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology are described, as well as uses of the enzymes and... Agent: Roal Oy

20110159546 - Process for the co-production of chitin, its derivatives and polymers containing glucose, mannose and/or galactose, by the fermentation of the yeast pichia pastoris: The presently disclosed subject matter concerns a process for the co-production of glucosamine polymers (chitin, chitosan or any of its derivatives) and polymers containing glucose, mannose and/or galactose, by the high cell density fermentation of the yeast Pichia pastoris in a bioreactor under aerobic conditions. The process can include the... Agent:

20110159548 - Method for amplifying monomorphic-tailed nucleic acids: The present teachings provide methods for amplifying a plurality of target nucleic acids. In some embodiments, a first oligo-dT-universal primer comprising a 3′ oligo-dT portion and a first 5′ universal portion is used to reverse transcribe a plurality of 3′ poly-A tail-containing nucleic acids. A poly-A tail is added to... Agent: Life Technologies Corporation

20110159547 - Polymerase chain reacton method, polymerase chain reacton droplet device, and polymerase chain reacton droplet device array: The present invention discloses a polymerase chain reaction (PCR) method, a PCR droplet device and a PCR droplet device array. The steps of the method comprise that a liquid comprising an analyzer is dropped on the heating coil disposed on the droplet device to form a droplet, then dropping a... Agent: National Applied Research Laboratories

20110159550 - Rna isolation from soluble urine fractions: The invention provides methods for isolating RNA from the soluble fraction of urine. The methods can be used for detecting the presence or absence of an RNA, or quantifying the amount of an RNA. The methods are useful for diagnosing an individual suspected of having a disease by detecting the... Agent:

20110159549 - Temperature control for light-emitting diode stabilization: A system is provided that includes a light-emitting diode (LED); a temperature sensor in thermal contact with the LED and capable of measuring an operating temperature and generating an operating temperature signal; and a temperature regulating system capable of receiving the operating temperature signal and regulating the operating temperature based... Agent: Life Technologies Corporation

20110159552 - Lactic acid bacteria-derived double-stranded rna: It is intended to provide an immunomodulator, which has a high safety and can be effectively incorporated into cells, and a method of producing the same. A double-stranded RNA originating in a lactic acid bacterium; an immunomodulator comprising the double-stranded RNA originating in a lactic acid bacterium as the active... Agent: Kikkoman Corporation

20110159551 - Cdna synthesis using a reversibly inactivated reverse transcriptase: The present invention provides compositions and methods for a reverse transcription reaction using a reversibly inactivated reverse transcriptase enzyme. The reversibly inactivated reverse transcriptase enzyme results from a chemical modification which inactivates the reverse transcriptase enzyme. The activity of the reverse transcriptase enzyme is recovered by an incubation of the... Agent: Life Technologies Corporation

20110159553 - Methods for detection of micro rna molecules: Methods and kits are provided for the production and use in microarray assays of labeled miRNA molecules and labeled cDNA molecules complementary to miRNA molecules.... Agent: Genisphere, LLC

20110159554 - Yeast for production of glucose, and method for production of glucose using the same: The invention provides: yeast having cellulose degradation ability that degrades cellulose outside the cell and glucose accumulation ability that accumulates, in a reaction liquid, glucose produced from cellulose as a result of the cellulose degradation ability, when the yeast was brought into contact with cellulose in the reaction liquid; and... Agent:

20110159555 - Methods, chimeric polypeptides, polynucleotides and cells for producing bioplastics: Methods of producing a bioplastic are disclosed. Furthermore, chimeric polypeptides useful to transport polyhydroxyalkanoates (PHAs) are disclosed, as are polynucleotides that code for the chimeric polypeptides, cells harboring the chimeric polypeptides and methods of transporting PHAs.... Agent: Utah State University

20110159556 - Use of hydroxyalkanoic acids as substrates for production of poly-hydroxyalkanoates by methane-oxidizing bacteria: A method of biosynthesis of polyhydroxyalkanoates (PHA) is provided that includes providing a type II methanotrophic bacteria, and disposing the type II methanotrophic bacteria in an unbalanced growth condition, where the unbalanced growth condition includes a nutrient-deficient media and a hydroxyalkanoic acid, and where the nutrient-deficient media has an absence... Agent:

20110159557 - Compositions and methods of pgl for the increased production of isoprene: Provided herein are improved compositions and methods for the increased production of isoprene. Also provided herein are improved compositions and methods for the increased production of heterologous polypeptides capable of biological activity.... Agent: Danisco US Inc.

20110159558 - Method for producing butanol using extractive fermentation with electrolyte addition: A method for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible organic extractant in the presence of at least one electrolyte at a concentration at least sufficient to increase the butanol partition coefficient relative to that in the... Agent: Butamax(tm) Advanced Biofuels LLC

20110159559 - Method for the combined production of butanol and hydrogen: The invention relates to a process for the combined production of butanol and hydrogen from biomass, comprising the steps of fermenting biomass to obtain butanol in a first reaction mixture; removing the butanol and hydrogen from the first reaction mixture to obtain effluent; and using the effluent as a substrate... Agent: Stichting Dienst Landbouwkundig Onderzoek

20110159560 - Modified yeast strains exhibiting enhanced fermentation of lignocellulosic hydrolysates: The present invention relates to novel xylose-fermenting yeast strains (for example, yeast of the genus Saccharomyces, e.g., S. cerevisiae) with an enhanced ability to ferment the xylose (and/or another pentose sugar) present in a lignocellulosic hydrolysate to a fermentation product(s) (for example, an alcohol (e.g., ethanol) or a sugar alcohol... Agent: Iogen Energy Corporation

20110159561 - Kit and method for the capture of tumor cells: The invention relates to a kit and method for the capture of tumor cells in a body fluid sample or a serum-containing sample. The kit and method of the invention can capture living tumor cells but not non-living tumor cells or cell fragments so that the tumor species can be... Agent: Taipei Medical University

20110159562 - Apparatus and methods for controlling cellular development: According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region... Agent:

20110159563 - Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.... Agent: Janssen Pharmaceutical Nv

20110159564 - Method for stabilizing coenzyme and composition thereof: Disclosed is a sugar and/or a sugar alcohol as a substance for suppressing dephosphorylation reaction of a phosphorylated coenzyme. Also disclosed is a method for stabilizing a phosphorylated coenzyme which is characterized by having at least a substance for suppressing dephosphorylation reaction of the phosphorylated coenzyme coexist with the phosphorylated... Agent: Asahi Kasei Pharma Corporation

20110159566 - Methods and reagents for preparing multifunctional probes: Multifunctional probes are synthesized in a single step using peptide scaffold-based multifunctional single-attachment-point reagents. To obtain multifunctional probes using the methods of the invention, a substrate (e.g., a nanoparticle, polymer, antibody, protein, low molecular weight compound, drug, etc.) is reacted with a multifunctional single-attachment-point (MSAP) reagent. The MSAP reagents can... Agent:

20110159565 - Reagents and processes for stabilizing alkaline phosphatase or conjugates thereof: The present disclosure relates to stabilizers for alkaline phosphatase or conjugates thereof, a process for preparing a stabilizer, and a method for stabilizing alkaline phosphatase or conjugates thereof with a stabilizer. The present disclosure also relates to a reagent of alkaline phosphatase or conjugates thereof as well as to a... Agent: Shenzhen Mindray Bio-medical Electronics Co., Ltd.

20110159567 - Ketoreductase polypeptides for the production of azetidinone: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent: Codexis, Inc.

20110159568 - Crystallographic structure of mnk-1 and mnk-2 proteins: The present invention relates to crystalline Mnk-1 and Mnk-2 kinases and, in particular, to the crystal structure of Mnk-1 and Mnk-2 kinase domain.... Agent:

20110159569 - Anti-nucleic acid antibody inducing cell death of cancer cells and composition for preventing or treating cancers comprising the same: There are provided an anti-nucleic acid antibody inducing cell death of cancer cells by invading normal cells; and a composition for preventing or treating cancers comprising the anti-nucleic acid antibody, which shows anticancer effect of an anti-nucleic acid antibody that shows cytotoxicity by damaging nucleic acid strands, that is, genetic... Agent: Ajou University Industryacademic Cooperation Found

20110159570 - Method for preparing maltogenic alpha-amylase variants: The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties, e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an... Agent: Novozymes A/s

20110159571 - Adenovirus targeting: This document provides methods and materials involved in targeting adenoviruses. For example, this document provides nucleic acid molecules encoding a γ-carboxylated glutamic acid (GLA) domain of a factor X (fX) polypeptide, polypeptides having a GLA domain of a fX polypeptide, adenoviruses containing such nucleic acid molecules, adenoviruses containing such polypeptides,... Agent:

20110159572 - Microorganisms for the production of 1,4-butanediol: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.... Agent: Genomatica, Inc.

20110159573 - Process for treating an effluent gas containing co2 with carbonic anhydrase having increased temperature stability: The present invention relates to polynucleotide and polypeptide sequences of novel carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic anhydrase.... Agent: Co2 Solution Inc.

20110159575 - Liquid-phase gas collection: A method for collecting combustion gases by (a) contacting a liquid phase with a gas flow containing said gases, where the liquid phase contains carbonate/bicarbonate buffer salts in a ratio of around 2:1, with a total inorganic carbon concentration no higher than 25 g/L and pH values between 8 and... Agent:

20110159574 - Separation and scrubbing system for exhaust gases: A separation and scrubbing system for exhaust gases includes a plurality of industrial discharge outlets, a separation unit, pipelines to direct exhaust gases from the industrial discharge outlets to the separation unit and pipelines to return treated exhaust gases to stacks corresponding to the industrial discharge outlets.... Agent:

20110159576 - Wastewater biosolids processing methods: A method to improve wastewater biosolids processing may include placing dried biosolids that have a moisture content lower than a moisture content needed for composting in a bioreactor. The method may also include processing the dried biosolids by controlling their temperature within the bioreactor while also reducing the moisture content... Agent:

20110159577 - Divider for use with biolistic bombardment device: The present invention is designed for use with a biolistic bombardment device having a cold gas shock wave splitter that divides a cold gas shock wave into two or more separate pressure waves that burst into one or more macrocarrier disks so as to create two or more separate microparticle... Agent: E. I. Du Pont De Nemours And Company

20110159578 - Multiple-input analytical system: The present disclosure provides an automated sample processing system that can receive samples in different first and second formats and process both sample formats. The disclosure also provides a human papillomavirus testing apparatus. The apparatus has a first input to receive first test specimens in the form of pre-processed cervical... Agent:

20110159579 - Thermal cycling reaction block and continuous real-time monitoring apparatus using the same: Disclosed is real-time monitoring apparatus comprising a thermal cycling reaction block having heating block which is formed of a hollow part and divided by an insulating layer, and a capillary tube through which a sample is flowed in and/or out and which is wound on the heating block so that... Agent: Bioneer Corporation

20110159580 - Method for preparing pellets from rice husk and apparatus for removing odor using rice husk pellet bio-media: A method for preparing pellets from rice husk includes: grinding rice husk; adding ammonia water to a mixture of ethylene vinyl acetate and poly(vinylacetate) to prepare a mixed liquid binder; mixing the mixed binder with the ground rice husk to obtain a binder/rice husk mixture; extruding the binder/rice husk mixture... Agent:

20110159581 - Photobioreactor for carbon dioxide mitigation in wastewater treatment: An airlift circulation micro-algae photoautotrophic-heterotrophic coupling photobioreactor for wastewater treatment carbon emission mitigation includes feeding pipe, micro-algae heterotrophic zone, gas-liquid separation chamber, micro-algae phototrophic zone, bottom backflow zone, discharge pipe, and the liquid drained zone.... Agent: Tongji University

20110159582 - Apparatus for the growth of artificial organic items, especially human or animal skin: The invention relates to an Apparatus for the growth of artificial organic items, particularly human or animal skin. The growth of skin is possible if a slowly stretched piece of skin or skin substitute is in contact with the nutrient fluid only on its inner side, and in contact with... Agent: Biomimetics Technologies Inc

20110159583 - Mn gene and protein: Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked... Agent:

20110159584 - Method of loading and distributing cells in a bioreactor of a cell expansion system: A method of distributing a plurality of cells in a bioreactor of a cell expansion system includes manipulating an orientation of the bioreactor such that a net impulse due to gravity acting on the plurality cells in the bioreactor is reduced. One method includes (a) rotating the bioreactor at an... Agent: Caridianbct, Inc.

20110159585 - Directly injectable formulations which provide enhanced cryoprotection of cell products: This invention provides compositions and methods for cryoprotection of recombinant live cancer cells. Specifically, an improved cryoprotective medium is provided which includes a hydroxyethyl starch and/or derivative thereof alone or in combination with either DMSO or glycerol.... Agent: Biosante Pharmaceuticals, Inc.

20110159587 - Chimeric molecules to modulate gene expression: The present invention provides a chimeric molecule including a base-pairing segment that binds specifically to a single-stranded nucleic acid molecule; and a moiety that modulates splicing or translation. The invention also provides a chimeric molecule including a base-pairing segment that binds specifically to a double-stranded nucleic acid molecule; and a... Agent:

20110159586 - Compositions and methods for modulating gene expression using asymmetrically-active precursor polynucleotides: The present invention is directed to novel nucleic acid molecules which include a region complementary to a target gene and one or more self-complementary regions, and the use of such nucleic acid molecules and compositions comprising the same to modulate gene expression and treat a variety of diseases and infections.... Agent: Halo-bio Rnai Therapeutics, Inc.

20110159588 - Methods for modulating a pdgf-aa mediated biological response: The present invention is directed towards methods and means for modulating PDGF-AA mediated biological responses and is based, at least in part, on examining the association of various proteins with TMEFF2 and identification of PDGF-AA as a major growth factor that interacts specifically with TMEFF2. The invention provides the first... Agent:

20110159589 - Methods of inhibiting inflammation with antagonists to il-17a, il-17f, and il-23p19: The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody... Agent: Zymogenetics, Inc.

20110159590 - Cell/tissue culturing device, system and method: A device, system and method for axenically culturing and harvesting cells and/or tissues, including bioreactors and fermentors. The device is preferably disposable but nevertheless may be used continuously for a plurality of consecutive culturing/harvesting cycles prior to disposal of same. This invention also relates to batteries of such devices which... Agent: Protalix Ltd.

20110159591 - Genetic material and chromosomal processing and manipulation methods: The presently claimed invention applies to a genetic material processing and manipulation method and related product. The claimed invention relates to a method for changing the inherited characteristics of a cell through chromosome processing treatment. In a preferred embodiment, ‘genomic surgery’ is applied to source genetic material 101. Micro-beam cutting... Agent:

20110159592 - Composition for reprogramming somatic cells to generate induced pluripotent stem cells, comprising oct4 in combination with bmi1 or its upstream regulator, and method for generating induced pluripotent stem cells using the same: Disclosed is a composition for reprogramming somatic cells to generate embryonic stem cell-like cells, comprising: a) a Bmi1 (B cell-specific Moloney murine leukemia virus integration site 1) protein or a nucleic acid molecule coding for Bmi1; and b) an Oct4 protein or a nucleic acid molecule coding for Oct4. Also,... Agent: Korea University Research And Business Foundation

20110159595 - Induction of flocculation in photosynthetic organsims: The present invention provides compositions and methods for producing flocculation moieties in photosynthetic organisms. The photosynthetic organisms are genetically modified to effect production, secretion, or both, of the flocculation moieties. Also provided are methods of flocculating organisms.... Agent:

20110159593 - Method of reducing motility in bacteria by overexpression of a gene of oi-1 genomic island: Z0021 was identified as a gene within the O-Island 1 (OI-1) genomic island of verocyto-toxin-producing E. coli O157:H7. The gene negatively regulates swimming motility and this decreased motility is the result of a reduction in surface expression of flagella. Overexpression of Z0021 suppresses the motility and surface expression of flagella... Agent:

20110159594 - Nucleic acids, bacteria, and methods for degrading the peptidoglycan layer of a cell wall: The invention encompasses compositions and methods for degrading the peptidoglycan layer of a cell wall. In particular, the invention encompasses compositions and methods for degrading the peptidoglycan layer of the cell wall of a gram-negative bacterium.... Agent: The Arizona Board Of Regents For And On Behalf Of Arizona State University

  
06/23/2011 > patent applications in patent subcategories. invention type

20110151428 - Methods and compounds for increasing red blood cell survival: Methods and compositions for increasing red blood cell survival and/or inhibiting hemolysis using indole-comprising compounds are described. Such methods and compositions may be useful for blood and blood product storage and preservation applications.... Agent:

20110151434 - Adeno-associated virus (aav) sequences and isolating novel sequences identified thereby: A method for detecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided, which sample contains DNA and proviral AAV. The method involves subjecting the sample containing DNA to amplification via polymerase chain reaction (PCR) using a first set of primers which specifically... Agent: The Trustees Of The University Of Pennsylvania

20110151429 - Bioprobe, method of preparing the bioprobe, and analysis apparatus and method using the bioprobe: The present invention relates to a bioprobe including a substrate and inorganic nanoparticles attached to the surface of the substrate, a method of preparing the bioprobe, and an analysis apparatus and method using the bioprobe. In the bioprobe according to the present invention, inorganic nanoparticles introduced to the substrate serve... Agent: Industry-academic Cooperation Foundation,yonsei University

20110151436 - Compositions and methods for the detection of hiv-1/hiv-2 infection: This invention relates to compositions and methods or the detection of immunodeficiency virus infection, especially immunodeficiency virus-1 (HIV-1) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-HIV-1 antibodies.... Agent: The Government Of The United States Of America As Represented By The Secretary, Dept. Of Health

20110151437 - Compositions for use in identification of adventitious viruses: The present invention provides compositions, kits and methods for rapid identification and quantification of adventitious contaminant viruses by molecular mass and base composition analysis.... Agent: Ibis Biosciences, Inc.

20110151431 - Detection of xenotropic murine leukemia virus: Methods of detecting, diagnosing, monitoring or managing an XMRV-related neuroimmune disease such as chronic fatigue syndrome or XMRV-related lymphoma such as mantle cell lymphoma in a subject are disclosed. These methods comprise determining presence, absence or quantity an XMRV nucleic acid in a sample from a subject.... Agent: Whittemore Peterson Institute For Neuro-immune Disease

20110151432 - Methods and systems to collect and prepare samples, to implement, initiate and perform assays, and to control and manage fluid flow: Methods and systems to related to sample collection, assays, and fluid control and management, including methods and systems to implement hand-held portable assays, to activate an assay system, to collect and prepare samples, to capture antibodies, and to trap or capture gas bubbles. Methods and systems disclosed herein, and portions... Agent: Boston Microfluidics

20110151433 - Methods for production of unstructured recombinant polymers and uses thereof: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous... Agent: Amunix Operating, Inc.

20110151435 - Novel assays for detecting analytes in samples and kits and compositions related thereto: The present invention provides methods of detecting analytes using particles having different physico-chemical properties, such as buoyancy, size, density, spectral characteristics, and/or binding properties, in solution-based sandwich assays and solution-based competition assays. The methods can be performed using rotors and bench-top centrifuges and provide for rapid, qualitative and quantitative detection... Agent: Abaxis, Inc.

20110151430 - Virus-specific mirna signatures for diagnosis and therapeutic treatment of viral infection: The present invention related to miRNA signatures and diagnostic and therapeutic applications of miRNA signatures. The miRNA signatures are defined by a test sample miRNA profile relative to an appropriate control miRNA profile. In some embodiments, the test sample is a sample isolated, obtained or derived from a virus-infected cell... Agent: University Of Massachusetts

20110151445 - Allelic disorders caused by mutations in trpv4: The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or... Agent: Northwestern University

20110151442 - Direct molecular diagnosis of fetal aneuploidy: Methods and materials for detection of aneuploidy and other chromosomal abnormalities using fetal tissue are disclosed. Results can be obtained rapidly, without cell culture. The method uses digital PCR for amplification and detection of single target sequences, allowing an accurate count of a specific chromosome or chromosomal region. Specific polynucleic... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20110151441 - Endpoint taqman methods for determining zygosity of corn comprising tc1507 events: A method for zygosity analysis of the maize Cry1F event TC1507 is provided. The method provides TC1507 event-specific and maize endogenous reference gene-specific primers and TaqMan probe combinations for use in an endpoint biplex TaqMan PCR assay capable of producing robust genotype calls for assisting in molecular breeding of TC1507.... Agent: Dow Agrosciences LLC

20110151443 - Marker for gastric cancer: Methods for detecting and assessing the progress and prognosis of gastric cancer are presented. Primers and probes for use in the methods are also disclosed as are methods for suppressing gastric cancer and kits for implementing the methods.... Agent: The Chinese University Of Hong Kong Room 328, Pi Ch'iu Building

20110151444 - Method for detection of an rna molecule, a kit and use related therefor: Described is a method for the detection of a RNA molecule, the method involving the steps of providing a sample containing the RNA molecule; hybridizing to the RNA molecule a first polynucleotide; extending the first polynucleotide to generate a first strand cDNA; hybridizing a second polynucleotide to the first strand... Agent:

20110151440 - Screening for arthrogryposis multiplex in bovines: Provided are methods, materials and kits for analyzing DNA samples from bovine to determine whether the animal is a recessive carrier of a genetic mutation that is associated with arthrogryposis multiplex (AM). DNA-containing samples are analyzed by genetic testing to determine whether or not a deletion mutation is present in... Agent:

20110151439 - System and method for the rapid identification of biological and chemical analytes: A system and method for the rapid identification of biological and chemical analytes that includes an enzyme substrate compound; an aptamer recognizing an analyte; and a recognition probe that comprises a first terminus operatively coupled to an enzyme catalyzing the enzyme substrate compound; a second terminus operatively coupled to an... Agent: United States Government As Represented By The Secretary Of The Army

20110151438 - Methods of analysis of methylation: Methods for determining the methylation status of a plurality of cytosines are disclosed. In some aspects genomic DNA target sequences containing CpGs are targeted for analysis by multiplex amplification using target specific probes that can be specifically degraded prior to amplification. The targets may be modified with bisulfite prior to... Agent: Affymetrix, Inc.

20110151446 - Cell treatment solution and method of preparing stained cell suspension for a measurement of nuclear dna by flow cytometry: A cell treatment solution and a method that is used for preparing a stained cell suspension that is provided to a measurement of nuclear DNA by flow cytometry. The cell treatment solution may include a surfactant, RNase, and a fluorescent dye. The surfactant may include, for example, a non-ionic surfactant,... Agent: Nihon Kohden Corporation

20110151450 - High fidelity restriction endonucleases: Methods and compositions are provided for engineering mutant enzymes with reduced star activity where the mutant enzymes have a fidelity index (FI) in a specified buffer that is greater than the FI of the non-mutated enzyme in the same buffer.... Agent: New England Biolabs, Inc.

20110151447 - Method to produce induced pluripotent stem (ips) cells from non-embryonic human cells: The invention provides methods for generating induced pluripotent stem (iPS) cells from normal and mutant adult cells, as well as the iPS cells so generated from such methods. In some aspects, iPS cells are generated by ectopically expressing SOX2 and OCT4 nucleic acids in such adult cells. Other nucleic acids... Agent: Children's Medical Center Corporation

20110151448 - Methods and systems for high homologous recombination (\"hr\") targeting efficiency: Disclosed are vectors, kits and methods useful in the construction of recombinant cells and DNAs via enhanced efficiency homologous recombination. The vectors are targeting vectors that contain a gene-of-interest spliced between two ends that are homologous to a genome target site. The ends of the vector may be protected from... Agent:

20110151449 - Short cycle methods for sequencing polynucleotides: The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion.... Agent: Helicos Biosciences Corporation

20110151461 - Detection algorithm for pcr assay: The application provides methods for improving the detection accuracy of the binding of labeled nucleic acid probes, such as those used in PCR reactions. One such method comprises measuring the label intensity, e.g. fluorescence, at two different temperatures, a higher temperature and a lower temperature, and then calculating the ratio... Agent: Smiths Detection-edgewood Inc.

20110151452 - Detection of staphylococcus aureus and identification of methicillin-resistant staphylococcus aureus: Aspects of the present invention relate to methods and compositions for the detection and/or quantification of S. aureus from a sample, as well as methods and compositions useful for the detection and/or quantification of S. aureus and MRSA in a single assay. Embodiments include nucleic acids that hybridize to S.... Agent:

20110151455 - Fish-ribosyn for antibiotic susceptibility testing: The subject invention concerns materials and methods for evaluating the susceptibility of bacterial cells to an antibiotic or other antimicrobial compound or agent. In one embodiment, a sample comprising a microbial population is exposed to an antibiotic of interest. The sample is then processed using FISH-RiboSyn methods to determine the... Agent: University Of South Florida

20110151454 - Gene expression markers of tumor resistance to her2 inhibitor treatment: The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.... Agent:

20110151457 - Hypertheromostable endonuclease iv substrate probe: The present invention relates to a hyperthermostable endonuclease IV substrate probe to be used in nucleic acid assay methods which can be carried out using hyperthermostable enzymes, including detection of target nucleic acids, and detection of nucleic acid polymorphism.... Agent: Elitech Holding B.v.

20110151458 - Methods and reagents for the detection of salmonella spp: The invention relates to an in vitro method for the detection of bacteria of the Salmonella spp. genus by means of a quantitative polymerase chain reaction using specific primers for said pathogen from DNA and RNA samples from said microorganism. Said method is useful in the detection of viable and... Agent: Universidad Del Pais Vasco

20110151460 - Methods and systems of using exosomes for determining phenotypes: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific... Agent: Caris Life Sciences Luxembourg Holdings A Luxembourg Corporation

20110151453 - Nucleic acid sequences and combination thereof for sensitive amplification and detection of bacterial and fungal sepsis pathogens: The present invention relates to methods of detection, as well as assays, reagents and kits for the specific detection of clinically important bacterial and fungal species. The present invention allows for the specific detection of nucleic acids of each of these pathogens in a single assay.... Agent:

20110151459 - Simultaneous detection of multiple nucleic acid sequences in a reaction: The present invention relates to a method for simultaneously amplifying and detecting nucleic acid sequences in a reaction comprising the following steps: (i) providing a sample comprising at least one nucleic acid molecule; (ii) providing reagents for performing an amplification reaction, wherein the reagents comprise at least four, preferably at... Agent: Qiagen Gmbh

20110151456 - Test method for type-2 diabetes using gene polymorphism: The present invention relates to a method of testing for genetic susceptibility to type-2 diabetes in a subject that comprises detecting one or more polymorphisms present in the KCNQ1 gene and/or EIF2AK4 gene in a DNA-containing sample collected from the subject. The present invention permit a method of accurately, conveniently,... Agent: National University Corporation Ehime University

20110151451 - Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectromety analysis of tissue sections: The invention concerns a method for determining at least one target molecule map in a tissue section, using at east one (A-X)n-B conjugate, wherein A is a tag molecule of known molecular weight, X is a linker that is cleaved during sample desorption/ionization, n is an integer of at least... Agent: Eurogentec S.a.

20110151462 - Bacterial vaginosis apparatus and diagnostic methods: The present disclosure relates to the filed of medical diagnostics, specifically directed towards the field of bacterial vaginosis diagnostic methods, systems and apparatus. Also included is a multiplexed platform test for the diagnosis of infectious vaginitis.... Agent:

20110151467 - Composition for detection of rna: A composition for use in amplifying cDNA synthesized by a reverse transcription reaction and detecting RNA that serves as a template of the reverse transcription reaction, the composition containing a thermostable DNA polymerase, a thermostable ribonuclease H, and an intercalating dye. Since the composition of the present invention can suppress... Agent:

20110151463 - Methods and systems for biological sample collection and analysis: Filtration devices for collection and filtration of biological samples are disclosed. Devices having a filtration element oriented in a generally vertical orientation are provided, as well as filtration devices that incorporate a cooling mechanism to reduce the temperature of collected solids. Tissue collection devices, such as aspiration assemblies, tissue sampling... Agent: Pathway Medical Technologies, Inc.

20110151466 - Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria: The present invention relates generally to detection of antibiotic-resistant bacteria in a sample. In particular, the invention provides methods, compositions and kits for detecting and analyzing methicillin-resistant Staphylococcus aureus (MRSA) and other methicillin-resistant bacteria in a sample.... Agent: Molecular Detection, Inc.

20110151464 - Urine gene expression ratios for detection of cancer: This invention relates to methods for determining the presence of cancer in a subject based on the analysis of the expression levels of an under-expressed tumour marker (TM) and at least one other TM. Specifically, this invention relates to the determination of a cancer, particularly bladder cancer, by performing ratio,... Agent:

20110151465 - Use of methylated or unmethylated line-1 dna as a cancer marker: The invention relates to a method of detecting LINE-1 (long interspersed nucleotide elements-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-1 DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression... Agent:

20110151470 - Biomarkers for assessing response to c-met treatment: Biomarkers that correlate to treatment with drugs that inhibit c-met are disclosed. These biomarkers have been shown to have utility in assessing response to the compounds. The expression level of the biomarkers is reduced upon treatment with c-met inhibitor compounds, thus indicating that these biomarkers are involved in c-met activity.... Agent: Janssen Pharmaceutica N.v.

20110151469 - Interferon epsilon (ifne1) as a marker for targeted cancer therapy: The present invention relates to a method employing Interferon Epsilon (IFNE1) as a therapeutic response, prognostic, or pharmacodynamic marker for cancer chemotherapeutic treatment involving the use of cyclin dependent kinase (CDK) inhibitors. The inventors have identified IFNE1 as a biomarker transcript that is upregulated when cancer cells are treated with... Agent: Piramal Life Sciences Limited

20110151468 - Methods and compositions for diagnostic use in cancer patients: Disclosed herein are methods and compositions useful for identifying therapies likely to confer optimal clinical benefit for patients with cancer.... Agent: Genetech, Inc.

20110151471 - Riboswitches, methods for their use, and compositions for use with riboswitches: It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches”... Agent: Yale University

20110151472 - Novel means for the diagnosis and therapy of ctcl: The invention relates to a novel molecule, termed SC5 by the inventors, to a novel allelic form of p140, and to the biological applications of SC5 and p140 molecules, notably in the diagnosis and therapy of CTCL.... Agent: Institute National De La Sante Et De La Recherche Medicale ( I.n.s.e.r.m.)

20110151473 - Polynucleotides and polypeptides encoding receptors: Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.... Agent: Human Genome Sciences, Inc.

20110151474 - Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by ugt1a1 enzyme or whose metabolic intermediate is metabolized by the enzyme: A method of estimating a risk of the expression of an adverse drug reaction caused by the administration of irinotecan, and a method of reducing the adverse drug reaction caused by the administration of irinotecan. A polymorphism on the basis of a difference in the repeating numbers of TA repetitive... Agent: Daiichi Pure Chemicals Co ., Ltd

20110151475 - Lab-on-a-chip and method of driving the same: Provided are a lab-on-a-chip and a method of driving the same. The lab-on-a-chip includes a first region where a lower substrate and an upper substrate are bonded to each other, a second region where the lower and upper substrates are not bonded to each other, a gap control member disposed... Agent: Electronics And Telecommunications Research Institute

20110151476 - Method of detection and/or titration in vitro of an unconventional transmissible agent: The invention relates to an in vitro method for the in vitro detection and/or titration of a non-conventional transmissible agent (NCTA) or of a protein of pathological conformation, which is a marker for infectiousness related to the NCTA, in a sample, comprising: replication or propagation, in cells in culture, of... Agent: Institut National De La Recherche Agronomique

20110151477 - Methods for detecting antibodies in mucosal samples and device for sampling mucosal material: A method to detect local antibodies such as antigen-specific IgE via a brush biopsy specimen of a mucosal surface of a subject is disclosed. The method is easily performed in an office setting on both adult and pediatric patients. Also disclosed is a brush device specially designed for harvesting materials... Agent: Cornell University

20110151479 - Microfluidic systems incorporating flow-through membranes: Disclosed is a flow-through membrane assay that takes advantage of a high surface area and rapid transport while allowing individual control over flow rates and times for each step of a multi-step assay. A microfluidic card features channels in communication with a porous membrane, channels on either side of membrane... Agent: University Of Washington

20110151478 - Transcriptional biomarkers and methods for detecting and isolating cancer cells in body fluids and tissue specimens: The invention provides molecules that target cancer-specific transcription complexes (CSTC), compositions and kits comprising CSTC-targeting molecules, and methods of using CSTC-targeting molecules for the treatment, detection and monitoring of cancer.... Agent: Oncotx, Inc.

20110151480 - Methods of purifying zsig33: The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.... Agent: Zymogenetics, Inc.

20110151484 - Herg mutants and uses thereof: An isolated nucleic acid molecule capable of expressing an human ether-à-go-go related gene (hERG) mutant that enhances hERG inactivation, wherein the mutation is not located in the vicinity of the drug-binding pocket within the cavity of the ion conduction pore of the hERG protein. Use of the isolated nucleic acid... Agent: Victor Chang Cardiac Research Institute Limited

20110151483 - Mammalian sweet and amino acid heterodimeric taste receptors comprising t1r3 and t1r1: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and... Agent:

20110151485 - Method for screening for antiangiogenic agent, and method for screening for antiangiogenic signal gene: Disclosed are a method for screening for an antiangiogenic agent and a method for screening for an antiangiogenic gene, both of which are achieved by detecting an antiangiogenic signal within a short time by a simple means. The method for screening for an antiangiogenic agent comprises: a candidate compound administration... Agent: National University Corporation Tokyo Medical And Dental University

20110151481 - Beta-2 microglobulin as a biomarker for peripheral artery disease: The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.... Agent: Vermilllion, Inc.

20110151482 - Automated developer for immuno-stained biological samples: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and... Agent:

20110151487 - Compositions and methods for the treatment of cancer: Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention discloses inhibitors of the Fanconi anemia pathway and methods using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, for example, in the treatment of cancer.... Agent:

20110151490 - Compositions for the detection and treatment of colorectal cancer: The invention provides methods of identifying proteins and polypeptides and their cognate polynucleotides that are expressed by cells under one environmental condition and not under a second environmental condition. The invention also provides compositions for the treatment and detection of cancer, including colorectal cancer.... Agent: Oragenics, Inc.

20110151488 - Detection and monitoring of liver damage: A method of detecting liver damage in a subject comprises measuring the level of caspase-3 generated cytokeratin-18 fragments in the bodily sample. The level of measuring the level of caspase-3 generated cytokeratin-18 fragments is then correlated with liver disease progression.... Agent:

20110151486 - Methods and systems to prevent gas bubbles from interfering with flow of fluid through a membrane region: Methods and systems to remove gas bubbles from liquids and to improve uniform fluid flow through a region of a membrane in a microfluidic device, including to reduce, remove, and/or prevent gas bubbles on a surface of a porous membrane. An example membrane bubble trap system may include a fluid... Agent: Boston Microfluidics

20110151489 - Monitoring skin metabolism products for evaluating burn injury: The present invention relates to methods and kits for evaluating the severity of a burn injury, which are based on the detection in a clinical fluid sample of skin metabolism products, such as collagen peptides which are released upon collagen degradation or synthesis.... Agent:

20110151491 - Portable coagulation monitoring device and method of assessing coagulation response: A device, system and method is disclosed in which small volume blood samples are subjected to shear forces and shear stresses between two parallel planar surfaces to which linear motion trajectories are imparted. The formation of clots or coagulation of the sample is measured from dynamic mechanical coupling which occurs... Agent: Entegrion, Inc.

20110151492 - Method of detecting articular cartilage degeneration or damage: d

20110151494 - Methods and materials for monitoring myeloma using quantitative mass spectrometry: The subject invention concerns methods and materials for diagnosing, monitoring the progress, and/or providing a prognosis for multiple myeloma and other conditions associated with antibody production in a person or animal. The methods o f the invention utilize mass spectrometry for quantitative monitoring and detection of antibody produced by the... Agent: H. Lee Moffit Cancer & Research Institute

20110151493 - Polypeptide disulfide bond analysis: The present invention relates in part to methods for determining bonding patterns in disulfide-linked peptides containing closely-spaced cysteine residues. Through N-terminal sequencing chemistry coupled with facile liquid chromatography and mass spectrometric analysis of the cleavage products, one can assign connectivity to specific cysteine pairs. A particular advantage of this method... Agent: Amgen Inc.

20110151495 - Method and menstrum for detecting the presence or absence of methicillin resistant staphylococcus aureus (mrsa) in a test sample: A dry mixture, a liquid menstrum, and a method, are described for use in detecting the presence or absence of Methicillin Resistant Staphylococcus aureus (“MRSA”) in a first generation biological or environmental specimen sample. First generation specimen samples that can be analyzed include nasal swabs, lesion swabs, skin swabs, throat... Agent:

20110151496 - Methods for identifying bacterial strains that produce l-tyrosine: The invention relates to high-throughput screens for identifying bacterial strains capable of L-tyrosine production.... Agent: Massachusetts Institute Of Technology

20110151498 - Apparatus and methods for conducting assays and high throughput screening: The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of... Agent: California Institute Of Technology

20110151499 - Apparatus and methods for conducting assays and high throughput screening: The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of... Agent: California Institute Of Technology

20110151500 - Blood-platelet test method and blood-platelet test device: A method for testing platelet function, wherein platelet function is tested by allowing anticoagulated blood, to which a weak platelet-activating reagent has been mixed, to pass through a capillary having a platelet-adhesive surface on at least a part of its inner surface, and observing or measuring the behavior of the... Agent:

20110151497 - Metabolomic profiling of prostate cancer: The present invention relates to cancer markers. In particular, the present invention provides metabolites and panels of metabolites that are differentially present in cancer (e.g., prostate or breast cancer).... Agent: The Regents Of The University Of Michigan

20110151501 - Modular system and method for detecting microorganisms: A modular automated system (10) for sample processing and/or detection of microorganisms is provided. The modular system includes modules (40a, 14, 40b, 50, 55) that perform at least one function in the process of detecting microorganisms in a culture device, such as collection of multiple samples, sample loading, sample preparation,... Agent:

20110151503 - Device and method for bacteriological testing on plasma: Apparatus for making a bacteriological test on plasma, comprising a sedimentation unit for a blood sample contained in a first container to separate the corpuscular part of the sample, which sediments on the bottom of the first container, from the liquid part or plasma, pick-up and inoculum means to pick... Agent: Alifax Holding Spa

20110151502 - Method for performing a blood count and determining the morphology of a blood smear: p

20110151504 - Methods and systems for efficient automatic slide staining in immunohistochemistry sample processing: Automated sample processing systems may include onboard efficient high-speed mixing of at least two components with an automatic vertical force fluidic turbulent component mixer of which a mixed component may be aspirated and high-speed dispensed in a mixing vial. Other aspects may include single sweep applying a multi-treatment cleaning cycle... Agent: Biocare Medical, LLC

20110151505 - Substance for specimen preparations and related methods: Disclosed are substances and methods for preparing cytological specimens.... Agent:

20110151506 - Process for culturing adherent cells: s

20110151507 - Solar biofactory, photobioreactors, passive thermal regulation systems and methods for producing products: The invention described herein relates to photobioreactors, methods, assembly and use of such apparatus for culturing light-capturing organisms in a cost-effective manner. Various embodiments provide for a passive thermal regulation system employing selected microorganisms in a photobioreactor apparatus and methods for biological production of various fuel and chemical products from... Agent:

20110151508 - Biodegradation process and composition: Disclosed are novel microbial compositions and biodegradation processes to treat marine animal or marine animal by-products to produce solid, liquid and lipid fractions that contain useful compounds.... Agent: Agrinos As

20110151509 - Preparation of 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof in transgenic organisms: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in... Agent: Organobalance Gmbh

20110151510 - Functional molecule and manufacturing method therefor: A novel method for efficiently manufacturing a functional molecule with affinity for a target substance is provided along with a functional molecule manufactured by this method. The method for manufacturing a functional molecule includes binding, to a resin, a specific substance having a cleavable linker which is a site that... Agent: Fujitsu Limited

20110151512 - Oligopeptide-free cell culture media: The present invention relates to oligopeptide-free cell culture media comprising at least 0.5 mg/L of a polyamine and to methods for cultivating cells in said oligopeptide-free cell culture media comprising at least 0.5 mg/L of a polyamine. The invention also relates to methods for expressing at least one protein in... Agent: Baxter Healthcare S.a.

20110151511 - Rapid growing microorganisms for biotechnology applications: The present invention provides novel rapidly growing microorganisms and methods for their use in cloning or subcloning nucleic acid molecules. The rapid growing microorganisms of the present invention form colonies more rapidly than microorganisms typically used in molecular biology and thus provide a significant improvement in in vitro cloning methods... Agent: Life Technologies Corporation

20110151515 - Production of fc-fusion polypeptides in eukaryotic algae: Methods and compositions are disclosed to engineer plastids comprising heterologous genes encoding immuno-activating domains fused to an extracellular domain (ECD) of a receptor or surface glycoprotein, a growth factor or an enzyme and produced within a subcellular organelle, such as a chloroplast. The immuno-activating domains may include those regions of... Agent: Sapphire Energy, Inc.

20110151513 - Shrna-mediated inhibition of expression of alpha-1,6-fucosyltransferase: The current invention comprises a method for producing a heterologous polypeptide with a reduced degree of fucose modification in a mammalian cell by cultivating the mammalian cell under conditions suitable for the expression of said heterologous polypeptide, and recovering the heterologous polypeptide from the mammalian cell or the culture, wherein... Agent:

20110151514 - Vectors, methods, systems and kits for protein purification: Disclosed herein are autocleaved peptide linkers for producing purified proteins. The autocleaved peptide linkers are inserted between a chitin binding protein (CBP) and a target protein to form a fusion protein. Upon expression of the fusion protein, it is allowed to pass a chitin matrix so that the CBP portion... Agent:

20110151516 - Process for the extraction of sugars and lignin from solid biomass: A process for the extraction of sugars and/or lignin from lignocellulose-containing solid biomass is provided.... Agent:

20110151517 - Process for the preparation of homopolysaccharides: A process for the preparation of aqueous solutions of glucans having a β-1,3-glycosidically-linked main chain and side groups having a β-1,6-glycosidic bond by fermentation of fungal strains. The fungal strains secrete the glucans into the fermentation broth, in an aqueous culture medium, and the separation of the glucans from the... Agent: Wintershall Holding Gmbh

20110151518 - Method for modifying chromosomes: The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign chromosome(s) or a fragment(s) thereof, and transferring said foreign chromosome(s) or a fragment(s) into a cell with high homologous recombination efficiency... Agent: Kyowa Hakko Kirin Co., Ltd.

20110151519 - Laboratory apparatus with an arrangement for the tempering of samples and method of tempering samples: The invention relates to a laboratory apparatus, in particular for performing a polymerase chain reaction (PCR) in a plurality of PCR-samples, which comprises an arrangement for tempering samples, the arrangement comprising a tempering block for the tempering of samples, the tempering block comprising a reception side, which provides receptacles for... Agent: Eppendorf Ag

20110151520 - Compositions and methods for cdna synthesis: Compositions are also provided comprising mixtures of reagents, including reverse transcriptases, buffers, cofactors and other components, suitable for immediate use in conversion of RNA into cDNA and RT PCR without dilution or addition of further components. These compositions are useful, alone or in the form of kits, for cDNA synthesis... Agent: Quanta Biosciences

20110151521 - Cdna synthesis improvements: The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for... Agent: Life Technologies Corporation

20110151522 - Glucoamylase variants: The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.... Agent: Novozymes A/s

20110151523 - Nitrogen compound production method and system: A nitrogen compound production method includes the step of establishing at least one aquatic plant in a cell containing water and alternating a step of inhibiting photosynthesis inducing light from reaching the at least one aquatic plant and a step of allowing photosynthesis inducing light to reach the at least... Agent:

20110151526 - Branched-chain fatty acids and biological production thereof: A method for producing anteiso fatty acid is provided. The method comprises culturing a cell comprising at least one exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes at least one of the following reactions: conversion of pyruvate to citramalate; conversion of citramalate to citraconate;... Agent:

20110151525 - Enzymatic production of unsaturated fatty acids esters of ascorbic acid in solvent-free system: The invention provides a cost-effective enzymatic process for the production of unsaturated FA esters of ascorbic acid, such as ascorbyl oleate or ascorbyl linoleate (E-304), in solvent-free system in which ascorbic acid esters of saturated FA, unsaturated free fatty acids and/or unsaturated fatty acid esters are used as feedstock. With... Agent:

20110151524 - Process for producing biodiesel through lower molecular weight alcohol-targeted cavitation: A method for producing fatty acid alkyl esters from biolipids through transesterification and/or esterification reactions uses a flow-through cavitation device for generating cavitation bubbles in a fluidic reaction medium. The fluidic medium is passed through sequential compartments in the cavitation device having varying diameters and inner surface features to create... Agent: Cavitation Technologies, Inc.

20110151527 - Production of biodiesel, cellulosic sugars, and peptides from the simultaneous esterification and alcoholysis/hydrolysis of materials with oil-containing substituents including phospholipids and cellulosic and peptidic content: The present invention relates to a method for producing fatty acid alkyl esters as well as cellulosic simplified sugars, shortened protein polymers, amino acids, or combination thereof resulting from the simultaneous esterification and hydrolysis, alcoholysis, or both of algae and other oil containing materials containing phospholipids, free fatty acids (FFA),... Agent: Inventure Chemical, Inc.

20110151528 - Process for producing organic acid: This invention is intended to improve the efficiency of organic acid fermentation in a simple manner without mutant breeding, DNA recombination breeding, or other means, when producing an organic acid via fermentation with the use of yeast that produces the organic acid of interest. The efficiency of the yeast's ability... Agent: Toyota Jidosha Kabushiki Kaisha

20110151529 - Methods and processes for producing organic acids: A fermentation process for the production of organic acids is provided and includes, providing metabolically engineered mutant bacteria which have had one or both of ack and pta genes disrupted, adapting the mutant bacteria to increase their resistance to acids and to increase their growth rate by immobilizing the mutant... Agent: The Ohio State University

20110151530 - Enzymatic production of 2-hydroxy-isobutyrate (2-hiba): The present invention concerns a new method for the biological preparation of 2-hydroxy-isobutyrate (2-HIBA), including a fermentation method with microorganisms modified to favour production of 2-HIBA from renewable resources. The invention also concerns the modified microorganisms used in such fermentation method.... Agent: Metabolic Explorer

20110151531 - Ethanol production by microorganisms: The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium.... Agent: Joule Unlimited, Inc.

20110151532 - Paenibacillus spp. and methods for fermentation of lignocellulosic materials: Provided herein are methods for producing a fermentation product, such as ethanol, by co-culture of a member of the genus Paenibacillus and an ethanologenic microbe, such as yeast or E. coli. Also provided are methods for making enzymes useful in the saccharification of a pretreated lignocellulosic material. The enzymes may... Agent: United Of Georgia Research Foundation, Inc.

20110151533 - Biogasification of coal to methane and other useful products: Method of bioconversion of coal to methane, carbon dioxide, and other valuable gaseous and liquid products in a multi-step process that may include particle size reduction, separation of non-coal materials, addition of chemicals, and multi-stage anaerobic fermentation are disclosed.... Agent:

20110151534 - Industrial production of organic compounds using recombinant organisms expressing methyl halide transferase: The invention relates to a process for production of organic compounds using genetically engineered organisms expressing a S-adenosylmethionine (SAM)-dependent methyl halide transferase and, optionally modified at loci that affect flux through SAM metabolic pathways or affect intracellular halide levels. In one approach the organism, halides (chlorine, bromine and/or iodine); and... Agent:

20110151535 - Separation of cultured cells: A first cell containing at least one magnetic particle is provided and a second cell is also provided. The second cell is cultured in the presence of the first cell. An alternating magnetic field is applied to the first cell. The alternating magnetic field at least partially separates the first... Agent: Empire Technology Development LLC

20110151538 - Affinity purification by cohesin-dockerin interaction: The present invention is directed to truncated dockerin polypeptides, recombinant polypeptides and affinity systems comprising the truncated dockerin polypeptide, methods of generating same, and methods of use thereof to purify, isolate, and detect molecules of interest.... Agent: Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science

20110151537 - Synthetic catalysts that separate co2 from the atmosphere and gas mixtures: The creation of a catalyst that can be used for a wide variety of applications including the steps of developing preliminary information regarding the catalyst, using the preliminary information to produce a template of the catalyst, and using the template of the catalyst to produce the catalyst.... Agent: Lawrence Livermore National Security, LLC

20110151536 - Thrombin activator compositions and methods of making and using the same: Disclosed are compositions for activating thrombin precursors to thrombin. The compositions provided include polypeptide compositions wherein the pre-pro-sequence comprises a thrombin cleavage site. The compositions provided also include polynucleotides encoding said polypeptides and recombinant systems for expressing said polypeptides. This disclosure also relates to methods for producing said compositions, recovering... Agent: Zymogenetics, Inc.

20110151539 - Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof: A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide.... Agent:

20110151540 - Process for the preparation of a phospholipase: A process for preparing a phospholipase D of vegetable or nut origin comprises: (i) providing a liquid extract of vegetable or nut origin; (ii) combining the liquid extract with a precipitating agent comprising at least one surfactant optionally in admixture with phospholipids, mono-, di- or triglycerides or a mixture thereof,... Agent: Loders Croklaan B.v.

20110151541 - Method for producing recombinant stem bromelain: The present invention relates to a method for producing recombinant stem bromelain. Total RNA is isolated from pineapple plant (11) and used for reverse transcription polymerase chain reaction to generate multiple copies of stem bromelain gene (12). The gene is then cloned into a cloning vector (13), then transformed to... Agent: International Islamic University Malaysia

20110151542 - Bionanomaterials and their synthesis: The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like... Agent: University Of South Carolina

20110151543 - Cell separation method using hydrophobic solid supports: Provided is a method of separating cells using a hydrophobic solid support. The method comprises contacting a solution containing cells with a hydrophobic solid support having a water contact angle between 70 and 90 degrees. By allowing cells to be adsorbed to the hydrophobic solid substrate, the cells can be... Agent: Samsung Electronics Co., Ltd.

20110151544 - Geobacter strains that use alternate organic compounds, methods of making, and methods of use thereof: In preferred embodiments, the present invention provides new isolated strains of a Geobacter species that are capable of using a carbon source that is selected from C3 to C12 organic compounds selected from pyruvate or metabolic precursors of pyruvate as an electron donor in metabolism and in subsequent energy production.... Agent: University Of Massachusetts

20110151545 - Non-photosynthetic micro-organisms enriched with organic selenium from seleno-hydroxyacid compounds and applications thereof in the fields of nutrition, cosmetics and pharmacueuticals: The invention relates to the enrichment of non-photosynthetic micro-organisms with organic selenium, and more particularly with selenomethionine, from a compound of the seleno-hydroxyacid type such as 2-hydroxy-4-methylseleno-butanoic acid in the (D, L) form or in the form of an enantiomer, salt, ester, or amide derivative of said compound, and to... Agent: Tetrahedron

20110151546 - Glycopeptide antibiotics: e

20110151547 - Reactor and method for treating contaminated water: A reactor and method are presented for processing water, in a manner enabling treatment of contaminated water to produce purified water and enabling simultaneous production of a biomass. The reactor comprises first and second compartments interfacing one another by a gas-permeable membrane. The first compartment serves for interaction between the... Agent:

20110151548 - Grease absorption system and method: An improvement is provided in grease trap assemblies for grease traps to be positioned on the roof of commercial buildings such as restaurants. The improvement comprises a system for degreasing that uses, in combination, a grease absorbent material that is porous rock, preferably lava, and a grease digestible microbe capable... Agent:

20110151549 - Device for carrying out an individual immunoassay in a fully automatic manner: The invention relates to a device for carrying out an individual immunoassay in a fully automatic manner in order to detect the presence of a biologically active substance in a sample, and to the use of one such device. The invention also relates to a sample strip which, in order... Agent:

20110151550 - System for multi color real time pcr: The invention is directed to a system for performing multi-color real time PCR, comprising a flexible real time PCR instrument and a specific composition or reaction mixture for performing multiplex PCR: In particular, the present invention is directed to a composition or reaction mixture which comprises at least 3, preferably... Agent: Roche Molecular Systems, Inc.

20110151551 - Bioreactors: The present invention relates to improved single-use bioreactors comprising disposable plastic bags for cell cultivation. The invention provides an inflatable bioreactor bag for cell cultivation comprised of a top and a bottom sheet of polymer material that are joined along their edges to form a sealed bag, wherein two opposing... Agent: Ge Healthcare Bio-sciences Corp.

20110151552 - Bioreactors: The present invention relates to improvements of bioreactor bags for cell cultivation. The invention provides an inflatable bioreactor bag for cell cultivation comprised of a top and a bottom sheet of polymer material that are joined along their edges to form a sealed bag, wherein two opposing edges are formed... Agent: Ge Healthcare Bio-sciences Corp.

20110151553 - Device and method for composting: A composter device is provided including a mixer and a grinder commonly driven and commonly located in a composting chamber of the device. A large opening at the top of the composting chamber permits large objects to be inserted into the chamber to permit the object to be ground and... Agent:

20110151554 - Method for culturing and subculturing primate embryonic stem cell, as well as method for inducing differentiation thereof: The present invention provides a method for subculturing primate embryonic stem cells, and a method for inducing differentiation of the same cell into a vascular endothelial cell and a blood cell. The present invention provides a method comprising culturing primate embryonic stem cells in a medium containing a protein component... Agent:

20110151555 - Compositions and methods for growing human embryonic cells: Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic gem (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or... Agent:

20110151556 - Methods for isolating mononuclear cells that include a subpopulation of mesenchymal progenitor cells and vascular cells that include a subpopulation of endothelial progenitor cells from umbilical cord tissue: Provided herein are methods and kits for the isolation, processing and cryopreservation of mesenchymal cells from the Wharton's Jelly and vascular progenitor cells from umbilical cord tissue. Also provided are isolated mesenchymal cells or vascular progenitor cells obtained by the invention methods, and compositions thereof.... Agent: Lifeline Cord Blood Bank

20110151557 - Compositions and methods for transfection of rna and controlled stabilization of transfected rna: The present invention provides reagents and methods for RNA transfection and protein expression... Agent: University Of Washington

20110151559 - Compounds for modulating trpv3 function: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.... Agent: Hydra Biosciences, Inc.

20110151558 - Methods and compositions for reducing target gene expression using cocktails of sirnas or constructs expressing sirnas: The present invention concerns methods and compositions involving the production or generation of siRNA mixtures or pools capable of triggering RNA-mediated interference (RNAi) in a cell. Compositions of the invention include kits that include reagents for producing or generating siRNA pools. The present invention further concerns methods using polypeptides with... Agent: Life Technologies Corporation

20110151560 - Differentiation of human embryonic stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.... Agent:

20110151561 - Differentiation of human embryonic stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to increase the expression of NGN3 and NKX6.1 in populations of cells expressing markers characteristic of the pancreatic endocrine lineage.... Agent:

20110151562 - White blood cell differentiation reagent and method: A reagent for four-part differentiation of white blood cells is provided. In one embodiment the reagent has an osmolality below 50 mOsm/kg H2O. A method for differentiating white blood cells using the reagent is also provided. The disclosure provides for a rapid lysis of red blood cells and four-part differentiation... Agent: Shenzhen Mindray Bio-medical Electronics Co., Ltd.

20110151563 - Collagen materials, films and methods of making same: In general, the present invention is related to collagen compositions and thin films, and to methods of making and using the same. In some embodiments, the present invention is directed to “woven pattern” or “basket pattern” collagen compositions and thin films, and methods of making.... Agent:

20110151564 - Method for proliferation of cells on polyelectrolyte multilayer films and use thereof, particularly for the preparation of cellular biomaterials: The invention relates to the use of a unit including a substrate and polyelectrolyte multilayer films deposited thereon in order to: carry out a method involving the proliferation of initial stem or differentiated cells that are brought into contact with the unit; and cover the unit with confluent viable adherent... Agent: Chu De Nancy-brabois

20110151565 - Cell sheet having good dimensional stability, method for production thereof, and cell culture carrier for use in the method: The cell culture carrier 1 of the present invention comprises: a support-held culture membrane 4 comprising an organic thin film 2 having cell adhesion properties and biodegradability and a frame-like support 3 fixed on the periphery of the organic thin film for maintaining the dimensions of the organic thin film;... Agent: Dai Nippon Printing Co., Ltd.

20110151566 - Biodegradable polymers, complexes thereof for gene therapeutics and drug delivery, and methods related thereto: A biodegradable cationic polymer is disclosed, comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a subunit derived from a monomeric diol initiator for the ring-opening... Agent:

20110151567 - Recombinant microorganism: A recombinant microorganism having improved productivity for a protein or a polypeptide, and a method for producing a protein or a polypeptide using the recombinant microorganism, are provided. A recombinant microorganism obtained by transfecting a gene for encoding a desired protein or polypeptide into a microorganism strain which is obtained... Agent: Kao Corporation

  
06/16/2011 > patent applications in patent subcategories. invention type

20110143331 - Methods and compositions for the preservation of cells and tissues: Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic,... Agent: Warsaw Orthopedic, Inc.

20110143333 - Anti-chikungunya monoclonal antibodies and uses thereof: The present invention relates to the field of arbovirosis caused by Chikungunya virus (CHIK). The present invention specifically concerns anti-CHIK monoclonal antibodies (MAbs), and more specifically anti-CHIK.E2 MAbs and their use as diagnostic products in methods for detecting the presence or absence of a CHIK strain.... Agent:

20110143336 - Marker for estimating the diagnosis of cervical adenocarcinoma or for estimating the prognosis of cervical cancer: To provide a novel biomarker for estimating the diagnosis of cervical adenocarcinoma or for estimating the prognosis of cervical cancer. An antibody against Villin 1 is employed as a biomarker.... Agent:

20110143332 - Method for identifying microorganism or detecting its morphology alteration using surface enhanced raman scattering (sers): The present invention also relates to a method for detecting morphology alteration of a microorganism due to an antimicrobial agent or an infectious agent based on SERS and an apparatus thereof. The method comprises: (1) placing the microorganism on a SERS-active substrate; (2) mounting the microorganism with a mounting solution;... Agent: National Yang-ming University

20110143335 - Methods and sytems to capture competitive molecules: Methods and systems to capture competitive molecules, such as to reduce false positives in an assay. Competitive molecules may be captured in a fluid moving through a portable point-of-care diagnostic assay system.... Agent: Boston Microfluidics

20110143334 - Microbiological systems and methods of fluid sample analysis: Methods and systems for detecting the presence of a target microorganism in a liquid sample are provided. Methods comprise the steps of passing the liquid sample through a surface filter, placing the surface filter into contact with a culture device, incubating the culture device for a period of time and... Agent: 3m Innovative Properties Company

20110143337 - Unsymmetrical cyanine dimer compounds and their application: Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one... Agent: Life Technologies Corporation

20110143339 - Device, system and method for processing a sample: A device for processing a sample comprises a blister defined by first and second walls. The first wall is flexible allowing the blister to be divided into one or more sealed regions by an external pressure applied to a portion of the first wall. The external pressure is applied in... Agent:

20110143341 - Microsatellite markers of schizophrenia: The invention includes methods of determining if a subject is at risk for developing schizophrenia (SZ).... Agent: University Of Louisville Research Foundation, Inc.

20110143340 - Non-invasive isolation of fetal nucleic acid: The present invention provides compositions comprising a solution of a compound useful for lysing biological cells and methods for using the compositions to lyse biological cells and to isolate nucleic acid.... Agent: Biocept, Inc.

20110143338 - Nucleic acid enzymes and complexes and methods for their use: The present invention relates to methods that utilise multi-component nucleic acid complex (MNA complex) cascades. The MNA complexes may have cleavage or ligase activity. Further, the invention provides cascades which may include one or more DNAzymes. The invention also provides methods which use these cascades for the identification, detection and... Agent: Johnson & Johnson Research Pty Limited

20110143346 - Cotton event mon15985 and compositions and methods for detection thereof: The present invention provides cotton plants, cotton tissues, and cotton seeds that include the MON15985 event, which confers resistance to Lepidopteran insect damage. Also provided are assays for detecting the presence of the MON15985 event based on the DNA sequence of the recombinant construct inserted into the cotton genome that... Agent:

20110143345 - Genetic markers for scd or sca therapy selection: Variations in certain genomic sequences useful as genetic markers of Sudden Cardiac Death (“SCD”) or Sudden Cardiac Arrest (“SCA”) risk are described. Novel genetic markers useful in assessing the risk of SCD or SCA and compositions containing the same are provided herein. Methods of distinguishing patients having an increased susceptibility... Agent: Medtronic, Inc.

20110143344 - Genetic polymorphisms and substance dependence: The invention encompasses methods for identifying subjects at risk for substance dependence by detecting the presence of polymorphism in the CHRNA5-CHRNA3-CHRNB4 gene cluster and the CHRNA4 gene. The invention also encompasses determining the response of a subject to a therapeutic substance, treating substance dependence in a subject, and evaluating the... Agent: The Washington University

20110143348 - Method for quantifying or detecting dna: The present invention relates to a method for quantifying or detecting DNA having a target DNA region, and so on.... Agent: Sumitomo Chemical Company, Limited

20110143349 - Methods and compositions for detecting bk virus: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of a BK virus in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved region of BK viral genomes. The invention also... Agent: Focus Diagnostics, Inc.

20110143343 - Methods and kits for methylation detection: Ligation-based methods and kits are disclosed for determining the degree of methylation of one or more target nucleotides. In certain embodiments, the methylation status of one or more target nucleotides is determined by generating misligation products. In certain embodiments, at least one target nucleotide is amplified prior to the ligation... Agent: Applied Biosystems, LLC

20110143342 - New fetal methylation markers: This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB2IP, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or... Agent: The Chinese University Of Hong Kong

20110143347 - Substances and methods for a dna based profiling assay: The present invention relates to a DNA profiling assay comprising the following steps, providing a sample to be analyzed, providing reagents, enzyme and primer oligonucleotides which are necessary for simultaneous polymerase chain reaction amplification of at least 20 loci, amplifying the loci, detecting the amplification products, wherein the amplification products... Agent: Biotype Gmbh

20110143358 - Compositions for use in identification of tick-borne pathogens: The present invention relates generally to the field of genetic identification and quantification of tick borne pathogens and provides methods, compositions and kits useful for this purpose when combined with molecular mass or base composition analysis.... Agent: Ibis Biosciences, Inc.

20110143351 - Glyosylation markers for cancer and chronic inflammation: The present invention provides novel biomarkers for use in the diagnosis and prognosis of cancerous and malignant conditions and further of diseases which are mediated by a proinflammatory immune response. The biomarkers are glycoproteins, the levels of expression of which have been correlated by the inventors to correspond to particular... Agent: National Institute For Biopr0essing Research And Training Limited

20110143353 - Method for in vitro detection and/or quantification and/or identification of infectious compounds in a biological material: Method for in vitro detection and/or quantification and/or identification of bacteria present in a fluid medium M constituting a biological material, in which method a suspension of microbeads of solid polymer material capable of binding proteins is prepared; the microbeads are loaded with β2GPI proteins; said loaded microbeads are brought... Agent: Apoh Technologies Sa

20110143352 - Methods for the reduction of stutter in microsatellite amplification: The invention provides a method for reducing stutter in the amplification of a microsatellite comprising the steps of providing a sample comprising a microsatellite having a G+C content of 50% or less; contacting the sample with at least one enzyme having nucleic acid polymerase activity; and incubating the sample with... Agent: Life Technologies Corporation

20110143350 - Primers and methods for the detection and discrimination of nucleic acids: The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR.... Agent: Invitrogen Corporation

20110143357 - System and method for high resolution analysis of nucleic acids to detect sequence variations: Provided herein are methods for assaying a biological sample for microorganisms having drug resistant and/or drug sensitive phenotypes, wherein the methods are capable of detecting resistant and sensitive phenotypes associated with known and/or unknown mutations. In some aspects, methods are provided for detecting drug resistant Myobacterium tuberculosis (MTb), including multi-drug... Agent: Signal Diagnostics

20110143355 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: Searete LLC, A Limited Liability Corporation Of The State Of Delaware

20110143356 - Thermostable polymerases having altered fidelity and methods of identifying and using same: The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase and screening the population for one or more active polymerase mutants by genetic... Agent: University Of Washington Through Its Center For Commercialization

20110143354 - Universal primers and their use for detecting and identifying plant materials in complex mixtures: Polynucleotides and primers flanking a variable region of the intron of the chloroplast gene trnL of plant materials for detecting and identifying plant species, and methods for detecting and identifying plant species in complex or degraded mixtures.... Agent: Recherche Scientifique

20110143359 - Method for identifying drug-sensitizing antisense dna fragments and use thereof: The invention provides a method for generating and selecting drug-sensitizing antisense DNA fragments. In one embodiment, the method includes identifying a gene of interest using knowledge of bacterial physiology, biochemistry, genetics, genomics, and other means. The method includes PCR amplification of a gene of interest using genomic DNA as a... Agent: Trius Therapeutics, Inc.

20110143360 - Cancer marker, method for evaluation of cancer by using the cancer marker, and evaluation reagent: The present invention provides a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject, and an evaluation method using the same. A cancer marker containing at least one miRNA selected from hsa-miR-92 and hsa-miR-494 is used as... Agent: Tokyo Medical University Tsuchida

20110143361 - Predictive value of nuclear excision repair genes for cancer survival: Patients who have their cancer surgically removed are at risk for recurrence, even though currently free of disease. Lung cancer patients with higher activity of a nuclear excision repair gene called ERCC1 were at a lower risk for recurrence than patients with lower activity of ERCC1. Hence, it is possible... Agent: University Of South Florida

20110143362 - Method for identification of protease activity inhibitors and assaying the presence of protease activity: A system for the identification of proteases and protease inhibitors is provided. The system has at least two components. The first component is a reporter construct with at least one binding site, a transcriptional promoter, an inducible promoter region, and at least one reporter gene, all functionally connected for expression... Agent:

20110143364 - Centrifugal micro-fluidic structure for measuring glycated hemoglobin, centrifugal micro-fluidic device for measuring glycated hemoglobin, and method for measuring glycated hemoglobin: Disclosed are a centrifugal micro-fluidic structure for measuring glycated hemoglobin, a centrifugal micro-fluidic device for measuring glycated hemoglobin, and a method for measuring glycated hemoglobin. According to the disclosure, immunosorbent assay and affinity measurements are simultaneously conducted using only a single device in order to detect hemoglobin variants or interfering... Agent: Samsung Electronics Co., Ltd.

20110143363 - Determination of free fractions: The invention relates to methods for the determination of pharmacological properties of substances, such as, e.g., chemical substances. The invention also relates to methods and kits for use in the determination of the free fraction, fu, of pharmacologically active compounds in aqueous solutions and serum. The invention also relates to... Agent: Bayer Schering Pharma Aktiengesellschaft

20110143365 - Methods and devices to enhance sensitivity and evaluate sample adequacy and reagent reactivity in rapid lateral flow immunoassays: Methods and devices for rapid lateral flow immunoassays to detect specific antibodies within a liquid sample while also validating the adequacy of the liquid sample for the presence of immunoglobulin and the integrity and immunoreactivity of the test reagents that detect the antibodies of interest, without requiring instrumentation. The methods... Agent:

20110143366 - Protein biomarkers for in vitro testing of developmental toxicity and enbryotoxicity of chemical substances: Presently, the toxicological assessment of chemicals is mainly performed in vivo using a variety of animal species and in addition taking into account human clinical, biochemical, pathological and morphological data. Over the past years it became increasingly clear that some substances are particularly harmful for children and thus there is... Agent: Proteosys Ag

20110143367 - Antibodies against april as biomarkers for early prognosis of lymphoma patients: The invention relates to antibodies directed against APRIL (A Proliferation Inducing TNF Ligand, also known as TALL-2), in particular the monoclonal antibody Aprily-2, hybridoma cells producing monoclonal antibody Aprily-2, and the use of a combination of an antibody against membrane-anchored APRIL and Aprily-2 in the diagnosis of B cell lymphoma... Agent: University Of Geneva

20110143372 - Antibodies against human epo receptor: An antibody binding to human EPO receptor, characterized in specifically binding EPO receptor fragment LDKWLLPRNPPSEDLPGPGGSVDIV (SEQ ID NO:1), CSSALASKPSPEGASAASFEY (SEQ ID NO:2), or GGLSDGPYSNPYENSLIPAAEP (SEQ ID NO:3) is useful for the analysis of EPO receptor in human tissue.... Agent: Hoffman-la Roche, Inc.

20110143375 - Biomarker detection process and assay of neurological condition: The subject invention provides a robust, quantitative, and reproducible process and assay for diagnosis of a neurological condition in a subject. The invention provides measurement of two or more biomarkers in a biological fluid such as CSF or serum resulting in a synergistic mechanism for determining the extent of neurological... Agent: Banyan Blomakers, Inc.

20110143373 - Method of evaluating the integrity of the plasma membrane of cells by detecting glycans found only intracellularly: The invention describes novel reagents that can be applied for analysis of the quality of human cells. The method evaluates the integrity of the plasma membrane of the cells by detecting novel glyco structures found only intracellularly. The method can be applied, for example, to demonstrate exposure of therapeutic cell... Agent: Glykos Finland Ltd

20110143376 - Methods to identify modulators: TAS2R7 was identified as a menthol-binding bitter taste receptor. Novel methods to identify modulators and in particular inhibitors to the bitter taste of menthol are provided.... Agent: Givaudan Sa

20110143374 - Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor tas2r46: TAS2R46 was identified as a dextromethorphan-binding bitter taste receptor. Novel methods to identify modulators and in particular inhibitors to the bitter taste of dextromethorphan are provided.... Agent:

20110143369 - Method for determining treatment of disseminated intravascular coagulation: A method for determining an appropriate treatment option for a patient who has been diagnosed with disseminated intravascular coagulation (DIC) but who may have thrombotic thrombocytopenic purpura (TTP), by analyzing the amount and/or enzyme activity of a von Willebrand factor (vWF)-cleaving protease (ADAMTS13) and the amount of vWF in a... Agent: Juridical Foundation The Chemo-sero-therapeutic Research Institute

20110143368 - Tyrosine phosphorylation sites: The invention discloses 142 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Cell Signaling Technology, Inc.

20110143370 - Nucleic acids encoding a mammalian raptor polypeptide and uses therefor: The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The... Agent: Whitehead Institute For Biomedical Research

20110143371 - Procollagen c-proteinase enhancer (pcpe) biomarker for bone formation: Use of PCPE, preferably PCPE-1, as a diagnostic marker.... Agent:

20110143380 - Alzheimer's disease biomarkers and methods of use: The invention encompasses biomarkers for AD, a method for detecting AD, a method of monitoring AD, and a kit for quantifying biomarkers for AD.... Agent: The Washington University

20110143379 - Detection and quantitation of full-length thioredoxin (trx) and truncated thioredoxin (trx 80) in complex samples: e

20110143381 - Diagnosis and monitoring of chronic renal disease using ngal: A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as... Agent:

20110143378 - Microfluidic method and apparatus for high performance biological assays: The present invention provides a disposable microfluidic assay cartridge (1) which will contain at least one sample inlet well (2) that will feed into a microfluidic sub-unit (3) embedded within the disposable microfluidic assay cartridge (1). The microfluidic sub-unit (3) contains a series of microfluidic channels and micro-valves (4) that... Agent: Cyvek LLC.

20110143377 - Protein fragments of virb10 and sero-detection of anaplasma phagocytophium: Disclosed are cloning and expression of a plurality of protein fragments of virB10, a Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum. Such recombinant protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as kits for ELISA is also disclosed.... Agent: Medical Diagnostic Laboratories, LLC

20110143382 - Iga nephropathy testing method and test kit: There is provided a renal disease testing method comprising a complex detection step of detecting a complex of an antigen derived from human renal mesangial cells and human IgA in a sample derived from urine collected from a subject. It is preferred that the renal disease testing method of the... Agent: Eisai R & D Management Co., Ltd.

20110143383 - Microfluidic device: e

20110143386 - Method for the analysis of o-linked oliosacharides: A method of analyzing O-linked oligosaccharides in a sample is disclosed. The method comprises the steps of digesting a glycoprotein with a proteolytic enzyme, performing solid-phase permethylation of the oligosaccharide, then analyzing the permethylated and non-reduced O-linked oligosaccharides using MALDI-TOF mass spectrometry.... Agent: Indiana University Research And Technology Corpora

20110143384 - Methods of peptide modification: The present invention relates to a method of improving the resistance of a peptide or peptidomimetic to degradation by trypsin which comprises incorporating into said peptide or peptidomimetic a C-terminal capping group of formula (I): X—Y—Z (I) wherein X is a N atom, which may be substituted by a branched... Agent: Lytix Biopharma As

20110143385 - Plasma membrane vesicles and methods of making and using same: The instant invention provides plasma membrane vesicles, methods of making the same, and method of using the plasma membrane vesicles.... Agent: Nanoxis Ab

20110143389 - Cell analysis apparatus and methods: Particular embodiments of the inventive technology relate to ‘off-axis detector’ technology that employs a third detector 23 exhibiting a flow orthogonal axis 43 as defined by its EMR collection angle, where such axis is from 30 degrees to 60 degrees from an intended, flow orthogonal, cell cross section long axis... Agent: Xy, LLC

20110143387 - Highly water-soluble, cationic luminescent labels: r

20110143388 - Method of providing portable biological testing capabilities: A method for providing portable biological testing capabilities free from biological contamination from an environment outside the device is provided. The method includes providing components configured to be assembled together to seal a volume against passage of biological materials between the volume and an environment outside the volume. The method... Agent:

20110143390 - Method for testing drug sensitivity and device used therefor: A method for testing drug sensitivity including: a) concentrating a bacterium or cell sample to be tested; b) adding a culture solution to the bacterium or cell sample to yield a liquid sample, the culture solution comprising a nutrient and a colloidal material; c) adding a coagulant aid to the... Agent:

20110143391 - Method for typing and identification of micro-organisms: The invention relates to a method for typing or identification of a micro-organism using vibrational spectroscopy, characterised in that, differences in one or more vibrational spectroscopic signal contributions from one or more bleachable components between different spectra obtained of a sample of said micro-organism, and/or between spectra of different samples... Agent:

20110143393 - Automatic device for carrying out detection reactions, and method for dosing reagents onto microscope slides: The invention relates to an automatic device to meter reagents onto a multitude of slides comprising holding devices for a multitude of slides which contain each a multitude of separated slots which are adapted to absorb cell or tissue samples; a dosing head unit with a multitude of reservoirs which... Agent:

20110143392 - Biological fixative and method of using the biological fixative: A composition that includes an aldehyde, alcohol, and a ketone, the volumetric ratio of the alcohol to the ketone in the composition ranging from as low as about 0.8:1 to as high as about 4.5:1 and the volumetric ratio of the alcohol to the aldehyde in the composition ranging from... Agent: Newcomer Supply, Inc.

20110143394 - Methods and means for metabolic engineering and improved product formation by micro-organisms: The invention discloses that DasR and DasR binding sites play an important and universal role in the control of gene expression in micro-organisms Based on this finding, the invention provides multiple useful applications, such as a method for regulating the expression of a gene of interest, a method for controlling... Agent: Friedrich-alexander-universitat Erlangen-nurnberg

20110143395 - Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic... Agent: Battelle Energy Alliance, LLC

20110143396 - Vectors and yeast strains for protein production: ca2+ atpase overexpression: Lower eukaryote host cells in which an endogenous or heterologous Ca2+ ATPase is overexpressed are described. Also described are lower eukaryote host cells in which a calreticulin and/or ERp57 protein are overexpressed. These host cells are useful for producing recombinant glycoproteins that have reduced O-glycosylation.... Agent:

20110143397 - Rna preparations comprising purified modified rna for reprogramming cells: The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease... Agent:

20110143398 - Methods of saccharification of polysaccharides in plants: Saccharification of polysaccharides of plants is provided, where release of fermentable sugars from cellulose is obtained by adding plant tissue composition. Production of glucose is obtained without the need to add additional β-glucosidase. Adding plant tissue composition to a process using a cellulose degrading composition to degrade cellulose results in... Agent: Applied Biotechnology Institute

20110143399 - Dna joining method: The present invention provides a method to directionally clone any linear template DNA molecule into any linearized vector. The vector ends may be generated from any restriction enzyme cleavage. The method does not require a ligation step nor the use of carefully controlled conditions as is required with methods involving... Agent: University Of Guelph

20110143400 - Sirna and methods of manufacture: Double-stranded RNA of about 19 to about 25 nucleotides in length capable of regulating gene expression by RNA interference is provided. Such double-stranded RNA are particularly useful for treating disease or conditions associated with a target mRNA or gene. Methods of manufacture and methods of use of the double-stranded RNA... Agent: Opko Ophthalmics, LLC

20110143401 - Devices to extend single stranded target molecules: A polynucleotide device is provided that add one or more bases to a single stranded polynucleotide. Methods of using the device and kits comprising the device are also provide.... Agent: Swift Biosciences, Inc.

20110143402 - Degradation of lignocellulosic material: The present invention describes a method for the treatment of lignocellulosic material which method comprises contacting said lignocellulosic material with a composition comprising two or more enzyme activities, said enzyme activities being cellulase and/or hemicellulase activities, wherein the pH during the treatment is about 4.5 or lower, and the treatment... Agent:

20110143403 - Method for producing l-amino acids using bacteria of the enterobacteriaceae family: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.... Agent:

20110143404 - Process for producing a phospholipid: A process for preparing phosphatidylserine comprises reacting a phospholipid with serine in the presence of water, a phospholipase D from carrot and at least one surfactant. A process for preparing phosphatide acid comprises hydrolysing a phospholipid in the presence of water and a phospholipase D from carrot.... Agent:

20110143405 - Dicarboxylic acid production in a recombinant yeast: The present invention relates to a recombinant yeast comprising a nucleotide sequence encoding a heterologous enzyme that catalyses the conversion of malic acid to fumaric acid. The invention further relates to a process for the production of a dicarboxylic acid wherein the yeast according to the present invention is used.... Agent:

20110143406 - Novel (s,s) -butanediol dehydrogenase, gene for the same, and use of the same: The present invention has its object to provide a novel (S,S)-butanediol dehydrogenase. The present invention also has its object to provide a gene coding for the enzyme protein, a vector containing the gene, a transformant harboring the vector, and a method of producing an optically active alcohol using the transformant.... Agent: Kaneka Corporation

20110143407 - Continuous single vessel butanol synthesis by fermentation: The present invention describes a method for producing butanol by fermentation of carbohydrates using mixed populations of acidogenic-phase cells and solventogenic-phase cells of Clostridium in a solitary vessel. The present system as described does not require intermittent adjustment of pH or venting of headspace gases. The method provides a process... Agent:

20110143409 - Method for producing ethanol from xylose using recombinant saccharomyces cerevisiae involving coupled use of nadh and nad+: Disclosed is a method for producing ethanol from xylose using recombinant Saccharomyces cerevisiae. In accordance with the method, NADH as a cofactor of xylose reductase required for the ethanol production, and NAD+ as a cofactor of xylitol dehydrogenase are coupled with each other and utilized, and acetaldehyde dehydrogenase mediating production... Agent: Snu R&db Foundation

20110143410 - Processes for producing fermentation products: The present invention relates to methods of increasing fermentation product yield in processes for producing fermentation products from starch-containing material. More particularly, the process comprises the use of an invertase to increase fermentation product yield.... Agent: Novozymes North America, Inc.

20110143408 - Zymomonas with improved arabinose utilization: Several strains of arabinose-utilizing Zymomonas were engineered to express an arabinose-proton symporter which was found to provide the strains with improved ability to utilize arabinose. These strains have improved ethanol production in media containing arabinose, either as the sole carbon source or as one sugar in a mixture of sugars.... Agent: E. I. Du Pont De Nemours And Company

20110143411 - Biomass fractionation process for bioproducts: A fractionation process for producing value-added products from a lignocellulosic biomass, comprises: a) mechanically refining the lignocellulosic biomass under mild refining conditions to form a refined biomass pulp with enhanced susceptibility to separation of hemicellulose, cellulose and lignin, and enhanced digestibility of carbohydrates in hydrolysis b) separating hemicellulose and sulfur-free... Agent: Fpinnovations

20110143412 - Method and apparatus for pretreating biomass using internal heat: A method for pretreating a biomass, in which a water-reactive anhydride contacts a biomass, is disclosed. The biomass is pretreated using internal heating by an exothermic reaction. Further, an apparatus for pretreating a biomass having a reaction part including an inlet part and an outlet part for the water-reactive anhydride... Agent: Samsung Electronics Co., Ltd.

20110143413 - System and method for controlling bacterial cells with weak electric currents: A system and method for treating bacterial cells with an electrochemical process, alone or in combination with antibiotics. Weak electric currents are used to effectively eliminate bacterial cells. The method may be adapted for novel therapies of chronic infections and strategies to control persistent biofouling. The system has broad spectrum... Agent: Syracuse University

20110143414 - Microfluidic device and method for concentration and lysis of cells or viruses: A microfluidic device for the concentration and lysis of cells or viruses and a method of concentrating and lysing cells or viruses using the microfluidic device include: magnetic beads, a reaction chamber in which the magnetic beads are accommodated and a laser source. The reaction chamber includes a plurality of... Agent: Samsung Electronics Co., Ltd.

20110143415 - Reprogramming normal and cancerous human cell lines into human induced poluripotent stem cells by co-electroporation with living xenopus laevis frog oocytes: Using electroporation, it is possible to activate the natural reprogramming potential of living Xenopus laevis oocytes and pass it on to donor cells placed with eggs in one electroporation chamber. We demonstrated that co-electroporation at 150 v/cm/25 μF of mature oocytes with ˜105 cells/ml of suspension of various normal and... Agent:

20110143416 - Stabilization of dehydrogenases with stable coenzymes: The present invention relates to a method for stabilizing an enzyme by storing the enzyme in the presence of a stable coenzyme. The present invention further relates to an enzyme stabilized with a stable coenzyme, and to the use thereof in test elements for detecting analytes.... Agent:

20110143417 - Stably tethered structures of defined compositions with multiple functions or binding specificities: The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization and docking domain attached to a first precursor, and a second monomer comprising an... Agent: Ibc Pharmaceuticals, Inc.

20110143418 - Compositions and methods relating to orthogonal mrna pairs: Orthogonal ribosome orthogonal mRNA pairs are provided, as are methods for their selection involving a novel positive-negative selection approach, and methods for their use. Also provided are cellular logic circuits involving orthogonal ribosomes.... Agent: Medical Research Council

20110143419 - Utilization of pharmacological chaperones to improve manufacturing and purification of biologics: The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of... Agent:

20110143420 - Kit for single oxygen atom incorporation into digested peptides: Optimized enzymatic conditions incorporate a single oxygen atom into digested peptides using a peptidase. The incorporation of a single oxygen atom is especially useful for proteolytic 18O labeling in comparative proteomics. The optimized proteolytic 18O labeling minimizes the generation of a mixture of isotopic isoforms of the peptides resulting from... Agent: University Of North Dakota

20110143421 - Novel protease and use thereof: (d) an amino acid sequence having deletion, substitution or addition of one to several amino acids in the amino acid sequence of SEQ ID NO: 3, has a high activity under high temperature and high alkaline conditions, a high stability to protein denaturants and surfactants and high effectiveness as a... Agent:

20110143422 - Recovery of recombinant human parainfluenza virus type 2 (hypiv2) from cdna and use of recombinant hpiv2 in immunogenic compositions and as vectors to elicit immune responses against piv and other human pathogens: Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric vector viruses, provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, and are useful in immunogenic compositions for eliciting... Agent: The Government Of The U.s.a, Represented By The Sectretary, Dept. Of Health And Human Services

20110143423 - Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by heat in the presence or absence of a small-molecule regulator: The present invention relates to conditionally replicating viruses or pairs of viruses containing a gene switch that is activatable by transient heat or other proteotoxic stress in the presence or absence of a small molecule regulator. The gene switch controls the expression of a gene for a protein required for... Agent:

20110143424 - Recombinant influenza viruses for vaccines and gene therapy: The invention provides compositions and methods useful to prepare segmented, negative strand RNA viruses, e.g., orthomyxoviruses such as influenza A viruses, entirely from cloned cDNAs and in the absence of helper virus.... Agent: Wisconsin Alumni, Research Foundation

20110143425 - Tissue-derived biomaterial carrier device: Disclosed is a tissue-derived biomaterial carrier device (1) comprising a carrier case 810), an arm (125) provided upright on an interior bottom wall surface of the carrier case (10), a mounting part (121), a swing mechanism (122), a temperature control box (20) provided detachably on an exterior wall surface of... Agent:

20110143426 - Device and process to generate co2 used for indoor crop production and underwater gardening: A process and device used to produce CO2 in an indoor environment is described. The device contains a container that contains a mixture of substrate and fungi. The container has at least one opening to permit the CO2 to enter the plant growth environment and a pump connected to the... Agent:

20110143428 - Anti-vegf-c antibodies and methods using same: The invention provides VEGF-C antagonists, such as anti-VEGF-C antibodies, and their use in the prevention and treatment of tumor progression.... Agent:

20110143430 - Hematopoietic stem cell identification and isolation: The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48− HSCs, and CD244− HSCs. The present invention also relates to purified cell samples with enriched CD150+ HSCs,... Agent: The Regents Of The University Of Michigan

20110143427 - High-throughput methods and systems for processing biological materials: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the... Agent: General Electric Company

20110143431 - Method of preparing an undifferentiated cell: Disclosed is a method of preparing an undifferentiated cell. The method includes contacting a more committed cell with an agent that causes the more committed cell to retrodifferentiate into an undifferentiated cell.... Agent:

20110143429 - Tissue engineered blood vessels: Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.... Agent:

20110143432 - Use of extract of selenium-enriched yeast (se-ye) in mammalian cell culture media formulations: The invention relates to the use of extract of selenium-enriched yeast (Se-YE) as a supplement to the serum-free cell culture media formulations. The cell culture media comprising this supplement are particularly suitable for cultivating mammalian cells and for production of recombinant proteins and monoclonal antibodies.... Agent: Cambrex Tallinn As

20110143433 - Microcarriers for stem cell culture: We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50... Agent: Agency For Science, Technology And Research

20110143434 - Diblock copolymers and polynucleotide complexes thereof for delivery into cells: Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one... Agent: Phaserx, Inc.

20110143435 - Polymeric carrier: Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.... Agent: Phaserx, Inc.

20110143436 - Compositions and methods for reprogramming eukaryotic cells: The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mRNA encoding one or more reprogramming factors into a cell and maintaining the cell under conditions wherein the cell is viable and the mRNA that is introduced into the cell... Agent:

20110143437 - Method for using directing cells for specific stem/progenitor cell activation and differentiation: A method is provided, including obtaining a population of antigen-presenting cells, enriching a population of stem/progenitor cells within a larger population of cells, activating the population of antigen-presenting cells and, following the activating, inducing at least one process selected from the group consisting of: differentiation, expansion, activation, secretion of a... Agent: Biogencell, Ltd.

20110143438 - Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced: The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability... Agent:

20110143439 - Method for manufacturing cell culture substrate: To attain the object, the invention provides a method for producing a cell culture substrate comprising: a patterning substrate forming process of forming, on a base material, a cell culture patterning layer wherein a cell adhesion portion having cell adhesive properties and a cell adhesion-inhibiting portion having cell adhesion-inhibiting properties... Agent: Dai Nippon Printing Co., Ltd.

20110143441 - Methods of reprogramming animal somatic cells: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to... Agent:

20110143440 - Mutations caused by activation-induced cytidine deaminase: Methods for causing mutations in genes expressed in eukaryotic cells are provided. The methods involve expressing an activation-induced cytidine deaminase (AID) in the cells. The mutated genes can be any gene that is operably linked to a promoter, where the gene is within about 2 kilobases of the promoter. Examples... Agent:

  
06/09/2011 > patent applications in patent subcategories. invention type

20110136095 - Bioreactor for producing a tissue prosthesis, particularly a heart valve: The invention relates to a bioreactor for producing a tissue prosthesis, particularly a heart valve, comprising a reactor chamber for holding a fluid nutrient medium and a prosthesis support, a device for placing the prosthesis support in the area of the reaction chamber, and a drive device for generating a... Agent: Universitaet Zuerich

20110136096 - Systems and methods for ex vivo organ care: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.... Agent: Transmedics, Inc.

20110136097 - Method for determining origin of alcohol or sugar containing products: A method for determining origins of food products, and more specifically for determining geographic and/or biological origin of food products containing alcohols or sugars includes preparing an alcohol sample from a product in question, removing exchangeable hydrogen/deuterium atoms from alcohol molecules of the sample, determining the isotopic composition of non-exchangeable... Agent:

20110136101 - Immortalized human fetal liver cells: The present invention provides immortalized fetal liver cells that express the oncogene Simian virus (SV 40) large T-antigen and specific hepatocyte markers and a method for producing same.... Agent:

20110136098 - Methods for simplifying microbial nucleic acids by chemical modification of cytosines: A method for detecting a microorganism comprising reducing the complexity of a microbial genome or microbial nucleic acid by generating a simplified form of the microbial genome or microbial nucleic acid in which substantially all of the positions naturally occupied by cytosines are occupied by uracil or thymine; and assaying... Agent: Human Genetic Signatures Pty. Ltd.

20110136099 - Multiplexed analyses of test samples: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test... Agent: Somalogic, Inc.

20110136100 - Non-human animal disease model for hepatitis b virus-associated disease: A non-human animal disease model for hepatitis B virus-associated liver disease is disclosed. The animal disease model is transduced with a hepatitis B virus genome in the liver cells thereof and exhibits the following symptoms: hepatitis B viral particles and hepatitis B viral DNA in the serum, hepatitis B virus... Agent: Academia Sinica

20110136102 - Surface impedance imaging methods and apparatuses: Methods and apparatuses for imaging surface impedance.... Agent: Arizona Board Of Regents For And On Behalf Of Arizona State University

20110136103 - Autoantibody enhanced immunoassays and kits: The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies reactive with the analyte.... Agent: Abbott Laboratories

20110136105 - Methods of quantifying nucleic acids: The present invention provides a method of detecting or quantifying a target nucleic acid by using fluorescently labeled oligonucleotide probes that do not rely on secondary structure or enzymatic action. The present invention provides improved methods of detecting or quantifying target nucleic acid by detecting or quantitating data during the... Agent: Evogen, Inc.

20110136104 - Multiplexed quantitative pcr end point analysis of nucleic acid targets: Certain embodiments of the present invention are directed to one pot multiplexed quantitative PCR methods for end point analysis of a plurality of nucleic acid targets in a complex sample without user intervention, and to various encoded particles on which are immobilized one or more probes that hybridize with the... Agent: Massachusetts Institute Of Technology

20110136107 - Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor2 (adipor2): The invention provides human AdipoR2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer,... Agent: Siemens Healthcare Diagnostics Inc.

20110136112 - Identification of bitter ligands that specifically activate human t2r receptors and related assays for identifying human bitter taste modulators: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates... Agent:

20110136113 - Marker for detecting il-17-producing helper t cell, and method for detecting il-17-producing helper t cell: Disclosed is at least one polynucleotide marker or protein marker which enables the specific detection of an IL-17-producing helper T cell (a Th17 cells). Also disclosed is a method for detecting a Th17 cell, which is characterized by comprising detecting the occurrence of the above-mentioned at least one marker.... Agent: Sysmex Corporation

20110136110 - Method for the production of medium-chain sophorolipids: The MFE2 gene of a microorganism capable of producing glycolipids, such as, but not limited to C. bombicola is disrupted with the purpose of blocking the beta-oxidation pathway in the strain. Fermentation of a such strain having such disrupted genes on primary or secondary alcohols or diols, preferably on primary... Agent:

20110136106 - Methods for detecting ricin and related compounds and uses thereof: The present invention is directed to methods for detecting the presence of ricin and compounds that catalyze the release of adenine from nucleic acids or other biological materials and for screening for inhibitors of such compounds.... Agent:

20110136111 - Nucleic acid ligands against infectious prions: The invention generally relates to nucleic acid ligands that specifically bind to infectious prions, and methods of diagnosing a transmissible spongiform encephalopathy disease in a subject. In certain embodiments, the invention provides an isolated nucleic acid ligand that binds to an infectious prion. In other embodiments, the invention provides a... Agent: Infoscitex Corporation

20110136109 - System and method for cycling liquid samples through a series of temperature excursions: A system and method for cycling liquid samples through a series of temperature excursions are disclosed. Provided are open-top reaction vessels for containing the samples, which may be enclosed by one or more covers. A temperature-controlled block for generating or adsorbing heat is coupled thermally to the reaction vessels. A... Agent: Roche Diagnostics Operations, Inc.

20110136108 - Xbp1(s) protein acting as an adipocyte differentiation marker having a facility to regulate differentiation into adipocytes, and an application therefor: Disclosed are a protein marker, indicative of an increase in differentiation into adipocytes, comprising an XBP1(S) having an amino acid sequence of SEQ ID NO. 1, 2 or 3, and the uses thereof in developing a promoter of adipocyte differentiation and a method for promoting adipocyte differentiation, a repressor of... Agent: Catholice University Industry Academic Cooperation Foundation

20110136119 - Aimp2-dx2 gene and its uses: The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer... Agent: Neomics Co., Ltd.

20110136116 - Detection of target nucleic acid sequences using fluorescence resonance energy transfer: A method for identifying a plurality of target nucleic acid molecules in a sample. The method provides a plurality of oligonucleotide probe sets. Each set comprises a first and a second probe, each having a target-specific portion and a tunable portion with an acceptor or a donor group. The first... Agent: Perdue Research Foundation

20110136121 - Method for detecting cancer: The present invention relates to a method for detecting cancer, comprising measuring the expression of a polypeptide having a reactivity of binding to an antibody against a CAPRIN-1 protein having an amino acid sequence shown in any one of the even-numbered SEQ ID NOS: 2-30 in the Sequence Listing via... Agent:

20110136117 - Method of detecting heat-resistant fungus: (II) a nucleic acid including a nucleotide sequence resulting from a deletion, substitution, or addition of one to several nucleotides in the nucleotide sequence set forth in any one of SEQ ID NOS: 24 to 35 and 83 to 86 and being capable of detecting the heat-resistant fungus, or a... Agent: Kao Corporation

20110136115 - Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.... Agent: Epigenomics Ag

20110136120 - Methods of identification of methylation of cpg: The present invention relates to the materials and methods for the identification of methylated nucleotides in samples of genomic DNA. The present invention also relates to methods of diagnosis of specific conditions by identification of specific methylated nucleotides.... Agent: Roche Molecular Systems, Inc.

20110136114 - Neural regenerating cells with alterations in dna methylation: Disclosed herein are cells, that are descendents of marrow adherent stem cells (MASCs), capable of rescuing and/or reversing various neural disorders after transplantation into sites of central nervous system (CNS) or peripheral nervous system (PNS) injury. The cells contain alterations in the methylation state of certain genes, compared to their... Agent: Sanbio Inc.

20110136118 - Real time polymerase chain reaction process using a universal detection system: Provided are methods and kits for detecting amplification of a target nucleic acid during a real time quantitative polymerase chain reaction process using a universal detection system. The detection system uses an unlabeled probe that detects the amplified target nucleic acid and interacts with a universal detection module.... Agent: Sigma-aldrich Co.

20110136123 - Alternative splicing gene variants in cancer: The present invention relates to a method to identify alternatively spliced variants enriched in cancer specimens and a method for prognosis of cancer in a subject by detecting a signature of splicing events. There is also provided a method for profiling cancer in a subject by detecting a signature of... Agent: Universite De Sherbrooke

20110136126 - Method for electrochemically identifying target nucleotide sequences: The present disclosure relates to a method and assembly for electrochemically identifying target nucleotide sequences. The method includes the following steps consisting of: supplying a biological sample that may contain a predetermined target nucleotide sequence; supplying activatable amplification means comprising free nucleotides in order to form replicated target nucleotide sequences;... Agent:

20110136125 - Method for the identification and quantification of microorganisms useful in biomining processes: The method comprises performing a PCR with specific primers designed in our laboratories for different taxons SEQ ID No. 4 to SEQ ID No.: 407. With qPCR results and other data obtained from the analyzed sample, the microorganism concentration of each analyzed taxon present in the sample is calculated using... Agent: Biosigma S.a

20110136127 - Methods and compositions for use in analyte detection using proximity probes: Methods and compositions for detecting an analyte in a sample are provided. In practicing the subject methods, a sample is combined with at least a pair of proximity probes that each include an analyte binding domain and a nucleic acid domain. The resultant mixture is then contacted with a pair... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20110136124 - Microrna expression profiles associated with lung cancer: The present invention is directed to sputum microRNA expression profiles associated with lung cancer and methods of using same for screening a subject for the disease.... Agent:

20110136122 - Nucleic acid detection using flow through methods: Methods and kits for use in detecting a target nucleic acid in a sample are disclosed. In one particular application, the methods and kits allow for the detection of an undesirable micro-organism (e.g. Listeriaceae, Enterobacteriaceae, or Staphylococcaceae) in food or present on a food preparation surface.... Agent:

20110136128 - Reporter assay screens for protein targets in saccharomyces cerevisiae: The present invention comprises responsive promoters along with screening methods which make use of the promoters in order to identify anti-fungal substances.... Agent:

20110136129 - Assessing atypical hyperplasia patients for the risk of developing breast cancer: This document provides methods and materials involved in assessing the risk of developing breast cancer in patients with atypical hyperplasia. For example, methods and materials for using the level of Ki67 expression (e.g., percent Ki67+cells or Ki67 staining intensity) to determine if a patient with atypical hyperplasia has an increased... Agent:

20110136130 - Method for chromogenic detection of two or more target molecules in a single sample: The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first... Agent:

20110136135 - Apparatus and method for processing biological samples: A method and an automated apparatus for processing at least one biological sample arranged on a slide. At least one capillary staining module has a slide rack holder configured to detachably hold a slide rack configured to hold slides, and a capillary lid rack holder configured to detachably hold a... Agent:

20110136132 - Immunodetection probe and method of immunodetection using the same: An immunodetection probe comprises a needle structure having a compartment and configured to be inserted into an organic tissue, a dialysis membrane configured to isolate the compartment from the organic tissue, a detection device having a detection portion and a plurality of receptors, a first optical fiber coupled to the... Agent: National Tsing Hua University

20110136134 - Method for assessing the damage of keratin fibers: Method for assessing damages of keratin fibers using a cationic fluorescent compound comprising a cationic ammonium group and being free of carboxyl and/or sulfonyl groups and method for comparing the damages of different keratin fibers using said cationic fluorescent compound. Said methods are useful for quantitatively and/or qualitatively assessing the... Agent:

20110136133 - Method for differentiating between multiple sclerosis subtypes: Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample obtained from the patient; and b) correlating the amount of the IAP gene expression level in the blood sample... Agent: Dianovix, Inc.

20110136131 - Method for measuring enzyme activity and column for use in measuring enzyme activity: s

20110136136 - Methods for detection of hydrophobic drugs: Methods and reagents are disclosed for pretreating a sample suspected of containing a hydrophobic drug for conducting an assay method for detecting the hydrophobic drug. A combination is provided in a medium. The combination comprises (i) the sample, (ii) a releasing agent for releasing the hydrophobic drug and the metabolites... Agent: Siemens Healthcare Diagnostics Inc.

20110136146 - Bioassay for polyq protein: The present invention relates to bioassays for mutated polyQ protein associated with disease and their use as diagnostic tools, for monitoring disease progression or for monitoring the efficacy of treatment of the disease. In a preferred embodiment the polyQ-protein is polyQ-huntingtin.... Agent: Novartis Ag

20110136144 - Fibroblast growth patterns for diagnosis of alzheimer's disease: Methods of diagnosing Alzheimer's disease are provided. At least five methods of diagnostic measurements are presented: Method 1: Integrated score; Method 2: Average aggregate area per number of aggregates; Method 3: Cell migration analysis; Method 4; Fractal analysis; Method 5: Lacunarity Analysis. In certain embodiments, a sample of a subject's... Agent:

20110136145 - Methods for promoting fusion and reprogramming of somatic cells: The invention features methods for reprogramming somatic cells by treating the cells with one or more agents to induce de-differentiation, in particular by targeting demethylase and methyltransferase genes. The invention also features methods of monitoring somatic cell fusion and reprogramming and methods of identifying agents that alter somatic cell fusion... Agent: The Johns Hopkins University

20110136149 - Method for predicting the response to her2-directed therapy: This invention provides methods for determining or predicting response to HER2-directed therapy in an individual.... Agent: Cell Signaling Technology, Inc.

20110136150 - Method of determination of receptor binding saturation effected by monoclonal antibodies: The invention relates to the determination of the degree of membrane receptor binding by specific monoclonal antibodies. This method is notably beneficial for monoclonal antibodies that are used in targeted therapies in order to define a target effective dose (TED). Especially the invention relates to the determination of the saturation... Agent: Merck Patent Gmbh

20110136147 - Methods of identifying tumor associated glycoproteins: Novel methods to identify and characterize glycoproteins that are likely to be found in serum, and that will therefore provide more relevant disease markers than current methods are disclosed. The proteins that are likely to be found in serum are distinguished either by cleavage from the membrane or as potentially... Agent:

20110136148 - Monoclonal antibodies against gmf-b antigens, and uses therefor: The disclosure relates to monoclonal antibodies (mAbs) preferentially selective for soluble GMF-B (sGMF-B) antigens or for sGMF-B as well as other forms of GMF-B, hybridoma lines that secrete these antibodies or fragments thereof, and the use of such antibodies and antibody fragments to preferentially detect sGMF-B antigens, including for example... Agent: Alper Biotech LLC

20110136151 - Assays for diagnosing and evaluating treatment options for pompe disease: Provided are in vitro, ex vivo and in vivo methods for determining whether a patient with Pompe disease will respond to treatment with a specific pharmacological chaperone.... Agent: Amicus Therapeutics, Inc.

20110136152 - Systems and methods for counting cells and biomolecules: The present invention generally relates to systems and methods for counting biomolecules or cells. In certain embodiments, the invention provides a cell counting or biomolecule counting system including: a covered chamber having a known height and configured to hold a suspension of biomolecules or cells in a sample; at least... Agent:

20110136138 - Method for predicting a need for renal replacement therapy (rrt): A method for predicting a need for Renal Replacement Therapy (RRT) in a patient comprises: determining a concentration of pi glutathione S transferase-(πGST) in a first urine sample from the patient; and wherein a need for RRT is predicted when the πGST concentration is determined to be elevated in comparison... Agent: Argutus Intellectual Properties Limited

20110136137 - Serum proteomic for finding diagnostic markers and for monitoring therapeutical intervention in treatment of hepatocellular carcinoma: The biomarkers are selected from a first group consisting of Amy 1, Apo Al, Carbx, Casp, AFP, ApoM, SAP, Fib-a, Fib-b, Fib-g, ApoE, A2MG, A2MG isoform, Serpin, Clusterin, MHC-fB, SAP isoform, or from a second group consisting of Gpx3, properidin, MUP1, HMW-K, Lifr-p, Orm 1, MBL-A, MBP-C, wherein the biomarkers... Agent:

20110136139 - Method for enhancing transport of semiconductor nanocrystals across biological membranes: Semiconductor nanoparticle complexes comprising semiconductor nanoparticles in association with cationic polymers are described. Also described are methods for enhancing the transport of semiconductor nanoparticles across biological membranes to provide encoded cells. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. Kits... Agent: Life Technologies Corporation

20110136140 - Diagnosis of systemic diseases: It has been found that the pattern of recognized topo I epitopes is different between dcSSc, IcSSc and SLE patients. Fragment F4 (amino acid (AA) 450-600) was recognized by all patients tested. Fragment F1 (AA 5-30) and Fragment F8 (AA 350-400) represent characteristic epitopes for dcSSc and SLE, respectively. The... Agent:

20110136142 - Immunochromatography method: It is an object of the present invention to provide an immunochromatography method capable of measuring a sample in a low concentration range and a high concentration range by setting the measurable range of the sample much wider than the conventional measurable range. The present invention provides an immunochromatography method,... Agent:

20110136143 - Modified cardiolipin and uses therefor: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized... Agent: The Government Of The United States Of America, As Represented By The Secretary Of The Department Of

20110136141 - Peptide reagents and method for inhibiting autoantibody antigen binding: The present disclosure provides immunoassays and kits for detection or quantification of an protein of interest in a test sample that potentially contains endogenously produced autoantibodies reactive with the analyte.... Agent: Abbott Laboratories

20110136155 - Peptides and methods for the detection of lyme disease antibodies: The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Borrelia antigens. The peptide compositions comprise polypeptide sequences comprising variants in the IR6 domain of the Borrelia VlsE protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for... Agent: Abaxis, Inc.

20110136153 - Use of vegf-d in the diagnosis of lymphangioleiomyomatosis (lam) disease: Described herein are methods of diagnosing lymphangioleiomyomatosis (LAM) that permits differentiating LAM from another lung disorder. Methods of treatment are also provided.... Agent: University Of Cincinnati

20110136154 - Voltage-gated metal-enhanced fluorescence, chemiluminescence or bioluminescence methods and systems: In the present invention, it is demonstrated for the first time, the influence of electrical current on the ability of surface plasmons to amplify fluorescence signatures. An applied direct current across silver island films (SiFs) of low electrical resistance perturbs the fluorescence enhancement of close-proximity fluorophores. For a given applied... Agent:

20110136156 - Luciferins: Novel luciferins, methods of making luciferins, and uses of the same are disclosed.... Agent: University Of Massachusetts, A Massachusetts Corporation

20110136157 - Copper regulation evaluation and therapy: Assays methods for clinical evaluation of conditions that might be treated with copper antagonists. These conditions include diabetes and other glucose metabolism disorders, lipid disorders, neurological disorders, and heart disease. The assays utilize a correlation between copper levels and one or more of the markers hemoglobin AIc and extracellular superoxide... Agent:

20110136158 - Protein electron mediator: The present invention relates to an electron mediator for glucose oxidoreductase comprising extracellular secretion type cytochrome, a fusion body in which the electron mediator is fused with glucose oxidoreductase, a composition for glucose measurement including the electron mediator or fusion body, a gene encoding a new extracellular secretion type cytochrome,... Agent:

20110136159 - Method and apparatus for viable and nonviable prokaryotic and eukaryotic cell quantitation: A rapid method for the quantitation of various live cell types is described. This new cell fluorescence method correlates with other methods of enumerating cells such as the standard plate count, the methylene blue method and the slide viability technique. The method is particularly useful in several applications such as:... Agent: Genprime, Inc.

20110136160 - Analysis of glycated proteins: This invention relates to a method for analysis of one or more glycated proteins in a sample, the glycated proteins containing moieties of a natural reducing carbohydrate bound at one or more glycation sites in the proteins, the method comprising: treating the sample with a stable isotopic form of said... Agent: Universite De Geneve

20110136161 - Use of procalcitonin (pct) in risk stratification and prognosis of patients with a primary, non-infectious disease: Subject of the present invention are assays and in vitro methods for the in vitro diagnosis, prognosis and risk stratification of a patient having a primary, non-infectious disease, whereby the level of Procalcitonin (PCT) in a sample of a body fluid of the patient is indicative for the risk of... Agent:

20110136164 - Cartridge device for blood analysis: A cartridge device having a receiving portion for receiving a blood sample and a jack portion for receiving a plug; a stirring device for circulating the blood sample within the receiving portion; and an electrode holder having at least one incorporated electrode wire pair; wherein the electrode holder is attachable... Agent:

20110136162 - Compositions and methods for functionalized patterning of tissue engineering substrates including bioprinting cell-laden constructs for multicompartment tissue chambers: The present invention relates to microfluidic systems and methods for monitoring or detecting a change in a characteristic of an input substance. Specifically, the invention relates to a model for in vitro pharmacokinetic study and other pharmaceutical applications, as well as other uses including computing, sensing, filtration, detoxification, production of... Agent: Drexel University

20110136163 - Method of toxicological assessment: A method of assessing toxicity of a candidate agent to a sample of cells comprises the steps of providing a sample of cells, exposing the cells to the candidate agent for a suitable period of time, assaying the cells to measure data for at least one parameter of cellular function;... Agent: University College Cork, National University Of Ireland, Cork

20110136165 - Detecting objects: The invention provides apparatus and methods for detecting objects in samples. The sample is held in the transmission path of light from a light source to a detector, whereby light from the light source interacts with objects in the sample. The patterns of light incident on the detector subsequent to... Agent:

20110136166 - Imaging mass spectrometry for improved prostrate cancer diagnostics: The invention provides biomarkers that can discriminate between prostate cancer and normal tissue as well as identification of associated metastatic disease. One biomarker was identified as a peptide fragment of MEKK2. Methods of diagnosing prostate cancer, including metastatic cancer, by detecting the differential expression of one or more biomarkers are... Agent: Eastern Virginia Medical School

20110136167 - Variants of glycoside hydrolases: The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally... Agent: Novozymes, Inc.

20110136168 - Process for production of non-natural protein having ester bond therein: A non-natural protein having at least one ester bond in its polypeptide main chain is synthesized by using an in vivo translation system in a ribosome. The following components (a) to (c) are expressed in a cell or an cell extraction solution in the presence of an α-hydroxy acid: (a)... Agent:

20110136169 - Expression system compositions and methods: The present invention relates to novel expression systems and methods for preparing samples for 3D structure determination of a protein based on a protein expression vector, E. coli host, and specific growth media.... Agent: Rutgers, The State University Of New Jersey

20110136171 - Improved protein expression system: Disclosed is a DNA polynucleotide comprising a nucleic acid sequence having promoter activity in a Drosophila S2 cell, where said nucleic acid sequence is selected from (i) a nucleotide sequence of SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO: 5, SEQ ID... Agent: Expres2ion Biotechnologies Aps

20110136170 - Method and kit for purification of recombinant proteins using a self-cleaving protein intein: The present invention provides a method for purifying a recombinant target protein by using an autolytic protein Intein, comprising: recombinantly expressing a fusion protein in a host cell, wherein said fusion protein comprises a target protein domain, an autolytic Intein and one or multiple hydrophobic granule binding domains, and wherein... Agent: Shantou University

20110136172 - Mammalian cytokines; related reagents: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering Corporation

20110136173 - Novel method for the stabilization of chimeric immunoglobulins or immunoglobulin fragments, and stabilized anti-egp-2 scfv fragment: The present invention relates to a method for stabilizing chimeric immunoglobulins or immunoglobulin fragments. Furthermore, the invention also provides a stabilized anti-EGP-2 scFv fragment.... Agent:

20110136174 - Method for producing cellulolytic enzyme using clostridium microorganism and method for culturing and proliferating clostridium microorganism: A method for producing cellulolytic enzyme, where clostridium microorganisms having cellulose utilizability are cultured, wherein after utilizable carbon source is consumed by the clostridium microorganisms, addition and consumption of the carbon source are repeated periodically to accumulate the cellulolytic enzyme in a culture medium.... Agent: Japan International Research Center For Agricultural Sciences

20110136176 - Method for treating lignocellulose raw material: A method for treating a lignocellulose raw material so as to facilitate a pulverization treatment that is necessary for the efficient and effective use of a lignocellulose raw material as a raw material or resource for material conversion. When converting a lignocellulose raw material into sugar or a useful material,... Agent: Yukiguni Maitake Co., Ltd.

20110136175 - Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic... Agent: Battelle Energy Alliance, LLC

20110136177 - Method of producing a low molecular weight organic compound in a cell: A method of producing a low molecular weight organic compound (e.g. a plant or bacteria secondary metabolite) in increased yields involving use of a microorganism cell, which comprises a gene involved in the biosynthesis pathway leading to a low molecular weight organic aglycon compound and a glycosyltransferase gene capable of... Agent: Blmaps

20110136178 - Base-modified primer oligomers for multiplex rt-pcr: The invention relates to a method for the amplification of nucleic acid sequences by enzymatic DNA polymerase activity, wherein synthetic oligodeoxynucleotide compounds are used as primers, comprising sequences having the formula (I), wherein the sequence SeqA-Ni-SeqC has at least a length of 8 nucleotides and can hybridize with one of... Agent:

20110136180 - Lysis and reverse transcription for mrna quantification: The present invention is directed to a method for performing an RT-PCR for amplifying a target RNA comprising the steps of a) lysis of a cellular sample which is supposed to contain the target RNA with a lysis buffer comprising between 0.2 M and 1 M Guanidine Thiocyanate, b) diluting... Agent:

20110136179 - Microfluidic biochip: The present invention provides a microfluidic biochip, which comprises: a fluid transportation unit having a fluid transportation reservoir and a fluid transportation air chamber; a first fluid storage reservoir; a second fluid storage reservoir; a first valve unit having a first valve and a first valve control air chamber; and... Agent: National Cheng Kung University

20110136181 - Rna polymerase mutant with improved functions: Disclosed is a T7 RNA polymerase mutant having improved thermal stability and/or specific activity in comparison with wild-type T7-like bacteriophage RNA polymerase, wherein at least one amino acid residue corresponding to at least one of the amino acid residues selected from the group at least consisting of glutamine at position... Agent: Tosoh Corporation

20110136182 - Swollenin compositions and methods of increasing the efficiency of a cellulase: Described are compositions and methods relating to enhancing the efficiency of cellulases for sugar production from cellulosic biomass using the polypeptide swollenin.... Agent: Danisco US Inc.

20110136183 - Method for producing alpha-1, 6-branched alpha-1, 4-glucans from sucrose: Nucleic acid molecules which encode a branching enzyme from a bacterium of the genus Neisseria, vectors, host cell, plant cells and plants containing said nucleic acid molecules as well as starch obtainable from the plants described are described. Furthermore, an in-vitro method for producing α-1,6-branched α-1,4-glucans on the basis of... Agent: Bayer Bioscience Gmbh

20110136184 - Method for producing alpha-1, 6-branched alpha-1, 4-glucans from sucrose: Nucleic acid molecules which encode a branching enzyme from a bacterium of the genus Neisseria, vectors, host cell, plant cells and plants containing said nucleic acid molecules as well as starch obtainable from the plants described are described. Furthermore, an in-vitro method for producing α-1,6-branched α-1,4-glucans on the basis of... Agent: Bayer Bioscience Gmbh

20110136185 - Epothilones c, d, e, and f, preparation and compositions: The present invention relates to epothilones C, D, E, and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection.... Agent: Helmholtz Center For Infection Research

20110136186 - Preparation of alpha-amino-epsilon-caprolactam via lysine cyclisation: The present invention relates to a method for preparing α-amino-ε-caprolactam, comprising converting lysine to α-amino-ε-caprolactam, wherein the conversion is catalysed by a biocatalyst. Further, the invention relates to a host cell comprising at least one recombinant vector comprising a nucleic acid sequence encoding a biocatalyst with lysine cyclase activity. Further... Agent:

20110136189 - Integrated processes and systems for production of biofuels using algae: A process for production of biofuels from biomass can include depolymerizing a biomass to form a feed. The feed can be formed by autotrophically growing algal biomass and extracting the feed therefrom. The algal feed can be converted to an algal oil by introducing the algal feed to an oil-producing... Agent: Genifuel Corporation

20110136187 - Process: A process of water degumming an edible oil (preferably a crude edible oil) comprising the steps of: a) admixing approximately 0.1-5% w/w water with an edible oil (preferably a crude edible oil) and a lipid acyltransferase, b) agitating the admixture for between about 10 minutes and 180 minutes at about... Agent: Danisco A/s

20110136188 - Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids and their use as percutaneous absorption enhancers: The present invention provides a novel approach for the preparation of fatty alcohol esters of α-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of α-hydroxy carboxylic acid is produced by converting a lower alkyl ester of α-hydroxy carboxylic acid into a fatty alcohol ester... Agent:

20110136190 - Recombinant bacteria for producing glycerol and glycerol-derived products from sucrose: Recombinant bacteria capable of producing glycerol and glycerol-derived products from sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct: a nucleotide sequence encoding a polypeptide having sucrose transporter activity; a nucleotide sequence encoding a polypeptide having fructokinase activity; and a nucleotide sequence... Agent: E. I. Du Pont De Nemours And Company

20110136191 - Processes for producing coenzyme q10: The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus produced reduced coenzyme Q10. The present invention... Agent: Kaneka Corporation

20110136192 - Flux to acetolactate-derived products in lactic acid bacteria: An engineering method was developed to allow genetic modification and isolation of lactic acid bacteria cells that lack lactate dehydrogenase and acetolactate decarboxylase activities. In cells with these modifications and an isobutanol biosynthetic pathway, improved production of isobutanol was observed.... Agent: Butamax(tm) Advanced Biofuels LLC

20110136193 - Method for producing butanol using extractive fermentation with osmolyte addition: A method is provided for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible organic extractant in the presence of at least one osmolyte at a concentration at least sufficient to increase the butanol partition coefficient relative to that... Agent: Butamax(tm) Advanced Biofuels LLC

20110136195 - Genetically-engineered yeast and methods of making and using: This disclosure describes genetically-engineered yeast that are able to uptake glycerol and convert the glycerol into ethanol.... Agent: Edeniq, Inc.

20110136194 - Method for increasing ethanol yield from grain: A process for increasing ethanol yield from grain comprising mixing grain, water and enzyme to for a grain-based liquid medium. The grain-based liquid medium is passed through a cavitation device at a velocity and pressure capable of generating a cavitation activation energy of at least 0.4 kJ per kilogram of... Agent: Arisdyne Systems, Inc.

20110136197 - Expression of catalase in trichoderma: The invention provides methods for expression of a catalase enzyme in a Trichoderma host cell. In one embodiment, the catR gene from Aspergillus niger is expressed in Trichoderma reesei, resulting in improved yields of catalase enzyme in comparison with expression of catR in A. niger.... Agent:

20110136196 - Fossil fuel-free process of lignocellulosic pretreatment with biological hydrogen production: The invention provides an isolated haloalkaliphilic microorganism designated as strain sapolanicus belonging to the genus Halanaerobium, which is capable of producing hydrogen from biomass. Methods of producing biohydrogen comprising the fermentation of the microorganism with alkaline pretreated biomass are also provided. Fermentation is preferably carried out without neutralization of the... Agent:

20110136198 - Hydrometallurgical procedure for the production of ferric-sulfate from fayalite slag: The present invention corresponds to a commercial production process of ferric sulfate whose plant can be installed scaled to the requirements of the process of application of the bio-produced ferric solution based on fayalite slag generated in copper smelting plants. No previous process has established as its method of industrial... Agent: Biosigma S.a.

20110136199 - Bacteria that reduce content of heavy metals in plant: This invention relates to bacteria having a function of reducing the content of heavy metals in plants, a method for reducing the content of heavy metals in plants with the use of such bacteria, and a composition comprising, as an active ingredient, such bacteria.... Agent:

20110136200 - Bacterial glutamine synthetases and methods of use: Compositions and methods for conferring herbicide resistance to and improving nitrogen utilization of bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a polypeptide that confers resistance or tolerance to herbicidal glutamine synthetase inhibitors are provided. The coding sequences can be used in DNA... Agent: Athenix Corp.

20110136201 - Heterocycle-substituted xanthene dyes: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research... Agent: Biotium, Inc.

20110136202 - Eukaryotic amadoriase, gene and recombinant dna for the eukaryotic amadoriase, and process for production of the eukaryotic amadoriase: Disclosed are: a eukaryotic amadoriase which is prepared by introducing a mutation into DNA encoding a eukaryotic amadoriase derived from a microorganism belonging to the genus Coniochaeta or Eupenicillium so as to introduce a substitution into a specific amino acid residue in the eukaryotic amadoriase, thereby overcoming the defect associated... Agent: Kikkoman Corporation

20110136203 - Enzymatical modif ication of cell glycosylation using serum albumin and divalent cations: The invention is directed to a method and kit to control and modify the status of cells, such as human stem cells, by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where culture medium reagents, such as divalent cations, are present and cells are kept... Agent: Glykos Finland Ltd

20110136204 - Extract of e. coli cells having mutation in ribosomal protein s12, and method for producing protein in cell-free system using the extract: It is intended to provide an extract, kit and a process for synthesizing a protein in a cell-free system. The extract is characterized by being prepared from mutant Escherichia coli cells having a mutation in the ribosomal protein S12 gene. In a preferred embodiment, the mutation is such a mutation... Agent: National Food Research Institute

20110136206 - Alpha-amylase variant with altered properties: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase.... Agent: Novozymes A/s

20110136205 - Alpha-amylase variants with altered properties: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards... Agent: Novozymes A/s

20110136207 - Mutated nucleotide sequences of batroxobin, mutated alpha factor secretion signal sequence and processes for preparing batroxobin using the same: The present invention relates to a batroxobin-encoding nucleotide sequence and/or a mutated α-factor secretion signal sequence, and a vector and a transformant using the same. The batroxobin-encoding nucleotide sequence of this invention exhibits an excellent expression efficiency in yeast, particular Pichia pastoris and the recombinant batroxobin is obtained at 4-13... Agent: Biobud Co., Ltd.

20110136208 - Antigen-specific regulatory t-cell induction: The present invention relates to an infectious particle having a surface displaying a ligand binding to a CD4 receptor for selectively infecting dividing CD4+ cells, said particle comprising: (a) one or more structural proteins, and (b) a vector containing a gene of interest functional in a CD4+ cell, said gene... Agent: Fraunhofer Gesellschaft Zur Forderrung Der Angewandten Forschung E.v.

20110136209 - Process for the preparation of nicotine-based haptens: e

20110136210 - Use of methylsulfonylmethane (msm) to modulate microbial activity: Disclosed herein are methods of use of methylsulfonylmethane (MSM) to modulate microbial activity, such as to enhance or inhibit the activity of microorganisms. In one example, MSM (such as about 0.5% to 5% MSM) is used to enhance fermentation efficiency, such as to enhance fermentation efficiency associated with the production... Agent: Biogenic Innovations, LLC

20110136211 - Mist or spray microorganism cultivation and related methods: Disclosed is an apparatus for culturing microorganisms and methods for using the same.... Agent:

20110136212 - Backward-facing step: Systems, methods and media for carbonation of fluid in an algae cultivation pond via the use of backward-facing steps are disclosed. In a first aspect, a method for initiating carbonation of a fluid flow in an algae cultivation pond is disclosed. Fluid flow is initiated over a backward-facing step in... Agent:

20110136213 - Three stage, multiple phase anaerobic digestion system and method: A three stage, multiple phase anaerobic digestion system and method designed to separate the biological phases, optimize microbial activity in each phase, and significantly increase system reliability and energy production. The system physically separates the biological phases of anaerobic digestion based on particle size, particle density, and solubility of metabolic... Agent:

20110136214 - Dust arrester and method for removing dust particles from air: A dust arrester includes a housing with air inlet and air outlet, wherein the ambient air containing dust particles can be introduced into the housing via the air inlet and discharged from the housing via the air outlet. The dust arrester further includes a water trough placed in the bottom... Agent:

20110136215 - Apparatus for stimulating cell: An apparatus for stimulating cell includes a cell culture chamber, a control device, and first and second exciters. The cell culture chamber includes cell and culture medium. The control device receives first and second exciting signals, and controls magnitudes and phases of the received first and second exciting signals so... Agent: Korea Advanced Institute Of Science And Technology

20110136216 - Diagnostic kit for respiratory disease: The present invention relates to a diagnostic kit for a respiratory disease that enables a preprocessing process with respect to a sample to be performed within a diagnostic kit when diagnosing respiratory disease using the diagnostic kit, and thereby enables all the operations starting from collecting the sample to verifying... Agent: Electronics And Telecommunications Research Institute

20110136217 - Integrated processes and systems for production of biofuels using algae: A process for production of biofuels from biomass can include depolymerizing a biomass to form a feed. The feed can be formed by autotrophically growing algal biomass and extracting the feed therefrom. The algal feed can be converted to an algal oil by introducing the algal feed to an oil-producing... Agent: Genifuel Corporation

20110136218 - Bioreactor chamber: Embodiments of the invention provide a bioreactor chamber assembly comprising: a bioreactor chamber comprising first and second portions arranged to be coupled to one another thereby to provide a liquid-tight seal therebetween; a pair of clamp members; and a pair of resilient loop elements, wherein the clamp members are arranged... Agent:

20110136219 - Thermal cycling apparatus and method for providing thermal uniformity: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.... Agent: Life Technologies Corporation

20110136220 - Method for isolating nuclei: This invention relates to methods of isolating cell nuclei from the other cell components in cell samples, e.g., cell samples from cell cultures or tissue samples. The method does not comprise ultracentrifugation or super-centrifugation rather the method comprises centrifuging cell samples in a table-top conventional centrifuge or microfuge. The method... Agent:

20110136221 - Thymidine kinase mutants and fusion proteins having thymidine kinase and guanylate kinase activities: The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution located toward the N-terminus from a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as... Agent: Darwin Molecular Corporation

20110136222 - Actuators for culturing and harvesting cells: Actuator units, arrangements of actuator units and methods for manufacturing and using actuator units are provided. The actuator includes a core having a shell at least partially surrounding the core. The core is able to be stimulated to expand through at least one opening of the shell to provide a... Agent: Empire Technology Development LLC

20110136225 - Bioreactor, devices, systems and methods: Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a... Agent: The Trustees Of Columbia University In The City Of New York

20110136224 - Mda-7 proteins and methods of use thereof: This invention provides a method of generating a subtracted cDNA library of a cell comprising: a) generating a cDNA library of the cell; b) isolating double-stranded DNAs from the cDNA library; c) releasing the double-stranded cDNA inserts from the double-stranded DNAs; d) denaturing the isolated double-stranded cDNA inserts; e) hybridizing... Agent:

20110136223 - Neurturin receptor: NTNRα, NTNRα extracellular domain (ECD), NTNRα variants, chimeric NTNRα (e.g., NTNRα immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNRα-ligands, for example NTN, by providing NTNRα to... Agent:

20110136226 - Stem cell bioprocessing and cell expansion: A stem cell niche for expanding stem cells in culture is described. The stem cell niche includes a scaffold, a plurality of stromal mesenchymal stem cells, and a plurality of umbilical cord blood stem cells grown in a rotating culture chamber. One embodiment of the rotating culture chamber has a... Agent: Synthecon, Inc.

20110136227 - Optimisation of expression of parvoviral rep and cap proteins in insect cells: The present invention relates to the improved production of recombinant parvoviral virions in insect cells. In particular, the invention relates to an improved process for the production of recombinant parvoviral virions in insect cells, wherein the full/empty parvoviral virion ratio is increased. The invention also relates to the production of... Agent: Amsterdam Molecular Therapeutics (amt) B.v.

20110136228 - Methods of cell culture for adoptive cell therapy: An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up... Agent:

20110136232 - Anti-pyk2 antibodies: This document provides methods and materials related to anti-Pyk2 antibodies. For example, anti-Pyk2 antibodies, methods for making anti-Pyk2 antibodies, and methods for using an anti-Pyk2 antibody to inhibit glioma cell migration are provided.... Agent:

20110136230 - Cultured hematopoietic stem cells and method for expansion and analysis thereof: Hematopoietic stem cells and methods for ex vivo expansion of hematopoietic stem cells are provided. The methods comprise culturing the cells in a media containing an effective amount insulin-like growth factor(IGF), fibroblast growth factor (FGF), thrombopoietin (TPO), and stem cell factor (SCF), under conditions sufficient for expansion of said cells.... Agent:

20110136231 - Methods and use of inducing apoptosis in cancer cells: The present disclosure relates to a method of inducing apoptosis in a cancer cell by delivery of exogenous Coenzyme Q1O or its metabolites thereof in a pharmaceutically acceptable carrier to effectuate cell contact of endogenous Coenzyme Q1O or its metabolites thereof in addition to but not limited to mevalonic acid... Agent: Cytotech Labs, LLC

20110136229 - Novel lectin: The present invention discloses a lectin, which is isolated from a plant belonging to the family Caricaceae. The lectin of the present invention includes a first subunit having a molecular weight of 38 kDa and a second subunit having a molecular weight of 40 kDa, wherein the lectin has a... Agent: National Taiwan University

20110136233 - Nucleic acid compounds for inhibiting plk1 gene expression and uses thereof: The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing gene expression of PLK1 gene. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein... Agent: Marina Biotech, Inc.

20110136234 - Cell culture substrate and its production method: e

20110136236 - Genetically modified eukaryotic cells: The invention relates to a method of producing genetically modified eukaryotic cells with optimised growth characteristics wherein a recombinant first nucleotide sequence has been integrated into a desired position in the genome. The sequence contains at least one gene encoding a plasma membrane protein with either toxin-receptor or toxic properties... Agent: Unitargeting Research As

20110136235 - Mk167 mini-promoters: Isolated polynucleotides comprising an MKI67 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of... Agent:

20110136237 - Site-specific recombination systems for use in eukaryotic cells: Prokaryotic recombination systems have been adapted to function in eukaryotes in order to achieve one or more of the following: DNA site specific excision, translocation, integration and inversion. These recombination systems are identified as seven members of the small serine resolvase subfamily: CinH, ParA, Tn1721, Tn5053, Tn21, Tn402, and Tn501... Agent: The United States Of America, As Represented By The Secretary Of Agriculture

  
06/02/2011 > patent applications in patent subcategories. invention type

20110129810 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Lifeline Scientific, Inc.

20110129809 - Methods for the anti-inflammatory and anti-edematous protection of explanted biological material until the transplantation thereof in patients: The invention relates to a method for protecting transplants, as well as organs and individual blood vessels, against inflammatory reactions that are caused by the operative procedure linked to the explantation and storage until transplantation. This can be achieved by treating the transplant via intra arterial application of flavonol compounds,... Agent: Boehringer Ingelheim International Gmbh

20110129811 - Cryopreservation and storage systems and methods: Embodiments provide improved systems and methods for preservation and storage of specimens for easy loading and releasing with rapid cooling and warming rates. Embodiments provide a system including an inner device that includes a specimen support located at or near the distal end of inner device and an outer sleeve... Agent: Scitech Invention, LLC

20110129812 - Method and apparatus for injection of co2 or stack gasses to increase algal biomass production: An algal production system that uses CO2 injections to promote the growth of algae. The system includes an algal growth medium within a floway for channeling water. A fluid diffuser also resides in the floway in proximity to the algal growth medium. The fluid diffuser injects CO2 into the water... Agent:

20110129813 - 2'-branched nucleosides and flaviviridae mutation: The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in... Agent:

20110129816 - Device for detection of influenza virus: A device for detecting or quantifying influenza viruses in a sample, which comprises a detection region having a human anti-influenza virus nucleoprotein antibody immobilized onto a support, a sample supply region, and a sample-migrating region; and a kit for detecting or quantifying influenza viruses, which comprises a solid phase in... Agent: Kyowa Medex Co., Ltd.

20110129815 - Method for pretreating sample for detection hcv core protein, reagent kit for detection of hcv core protein, method for determining the presence or absence of hepatitis c virus in sample, and method for immunoassay of hcv: There are provided: a method for pretreating a sample for HCV core protein detection by an immunoassay using particles, which includes treating a sample suspected of containing hepatitis C virus (HCV) with an alkaline material-containing reagent and neutralizing the sample with an acid material-containing reagent, wherein at least one of... Agent: Sysmex Corporation

20110129814 - Process and system for detecting and/or quantifying bacteriophages, use of a microelectronic sensor device for detecting said bacteriophages and microelectronic sensor device for carrying out said process: The present invention relates to a process and system for detecting and/or quantifying bacteriophages capable of infecting a predetermined bacterial host strain, which is based on the surface plasmon resonance technique that takes place on the conductive material surface of an optical sensor device, and also relates to a microelectronic... Agent: Consejo Superior De Invstigaciones Cientificas

20110129818 - Assay for cardiac troponin-t (ctnt): The present disclosure describes immunoassays for detecting cardiac troponin-T (cTnT) in a test sample, and in particular immunoassays and kits for detecting cTnT in a test sample suspected of containing substances that may interfere with the determination of cTnT, such as heterophilic endogenous antibodies and autoantibodies to cTnT. The methods... Agent: Abbott Laboratories

20110129817 - Blood transcriptional signature of active versus latent mycobacterium tuberculosis infection: The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with Mycobacterium tuberculosis, the method including the steps of obtaining a patient gene expression dataset from a patient suspected of being infected with Mycobacterium tuberculosis; sorting... Agent: Imperial College Healthcare Nhs Trust

20110129819 - Diagnosis of hereditary spastic paraplegias (hsp) by indentification of a mutation in the kiaa1840 gene or protein: The invention relates to an ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein said mutation is indicative of. an hereditary spastic paraplegias (HSP).... Agent:

20110129823 - Enzymatic detection techniques: A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter... Agent: Kimberly-clark Worldwide, Inc.

20110129820 - Human diabetes susceptibility tnfrsf10b gene: The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the TNFRSF10B gene locus in a biological sample of said subject.... Agent: Integragen

20110129821 - Methods for cyclic nucleotide determination: The present invention relates in general to cellular analysis tools and more particularly to methods for detecting or determining cyclic nucleotide concentrations in samples. Samples containing cyclic nucleotides may be contacted with a cyclic nucleotide-dependent protein kinase and a detection system which includes a substrate for the cyclic nucleotide-dependent protein... Agent: Promega Corporation

20110129822 - Multi drug response markers for breast cancer cells: The present invention provides methods for preparing a gene expression profile of a breast cancer cell, tumor, or cell line, where the gene expression profile may be evaluated for one or more gene expression signatures indicative of multidrug resistance. The signature may be indicative of resistance to one or more... Agent: Precision Therapeutics, Inc.

20110129836 - Automated seed sampler and methods of sampling, testing and bulking seeds: An automated seed sampler includes a sampling station; a sampler for removing material from a seed in the sampling station; a seed conveyer for conveying the seed from the sampling station to a compartment in a seed tray; and a conveyor for conveying the material removed from the seed to... Agent: Monsanto Technology LLC

20110129825 - Compositions, methods and systems for the simultaneous determination of parentage, identity, sex, genotype and/or phenotype and breed determination in animals: The invention provides for a universal genetic evaluation system capable of simultaneously determining multiple genetic characteristics in domestic and wild animals. In particular, the invention provides for the use of polymorphisms, such as single nucleotide polymorphisms (SNPs), insertions, deletions, inversions, and/or other mutations within gene sequences, as determinants of genetic... Agent:

20110129837 - Detection of nucleic acids and proteins: The invention generally relates to methods for detecting a target nucleic acid and a target protein in a single assay.... Agent: Predictive Biosciences, Inc.

20110129830 - Determination of kir haplotypes associated with disease: Disclosed is a method of determining KIR genotypes for one or more individuals in parallel, the method comprising: for each individual, amplifying the polymorphic exon sequences of the KIR genes, pooling the KIR amplicons, performing emulsion PCR followed by pyrosequencing in parallel to determine all the amplicon sequences present in... Agent: Roche Molecular Systems, Inc.

20110129824 - Double-stranded probes for the fluorescent detection of nucleic acids: The present invention relates to a double-stranded probe intended for the fluorescent detection of at least one single-stranded or double-stranded target nucleic acid, comprising: —a first strand of formula X1-(L1)a-S1-S′1-(L′1)b-Y1 intended for the detection of a first strand of the target nucleic acid which comprises a sequence of formula T1-T1;... Agent: Bio-rad Pasteur

20110129833 - Gene expression markers for predicting response to chemotherapy: The present invention provides sets of genes the expression of which is important in the prognosis of cancer. In particular, the invention provides gene expression information useful for predicting whether cancer patients are likely to have a beneficial treatment response to chemotherapy. FHIT; MTA1; ErbB4; FUS; BBC3; IGF1R; CD9; TP53BP1;... Agent:

20110129831 - Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and... Agent: Celera Corporation

20110129826 - Method for determination of inflammatory disease by using single nucleotide polymorphism in brca1-related protein (brap) gene: It is an object of the present invention to identify a novel single nucleotide polymorphism (SNP) associated with the development and advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging inflammatory diseases, which comprises detecting at least one gene polymorphism in the BRCA1-associated... Agent: Riken

20110129835 - Methods and compositions for detecting methicillin-resistant staphylococcus aureus: Provided are methods of detecting the presence and/or amount of methicillin-resistant S. aureus in a sample. The methods may include, in some embodiments, processing the sample with a lysyl endopeptidase followed by amplification and detection of S. aureus chromosomal DNA if present in the sample. The PCR amplification may include... Agent: Physicians Reference Laboratory, LLC

20110129829 - Methods for detection of corn event das-59132: The invention provides assays for detecting the presence of the maize DAS-59132 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.... Agent: Dow Agrosciences LLC

20110129827 - Methods for transcript analysis: The invention takes a unique approach to transcript analysis that provides a novel DGE technology based on single-molecule sequencing. More particularly, the invention relates to methods and compositions for analyzing and identifying genes and gene expression and transcript profiles using a DGE-based technology and single molecule sequencing that does not... Agent: Helicos Biosciences Corporation

20110129832 - Polynucleotide primers and probes: The present invention provides a novel technology that involves improved primer design. These primer pairs have a wide range of applications and provide high sensitivity and specificity.... Agent: Swift Biosciences, Inc.

20110129834 - Selective amplification of polynucleotide sequences: The application relates to compositions and methods which may be used for amplifying selected portions of nucleic acid samples. Samples may comprise an entire genome of a bacterium, plant, animal, or other organism. In some instances, methods allow for enrichment of hundred or thousands of target nucleic acids of interest... Agent: Life Technologies Corporation

20110129828 - Specific double-stranded probes for homogeneous detection of nucleic acid and their application methods: Nucleic acid detection probes that comprise a pair of complementary, fluorophore/quencher labeled oligonucleotides, one of which is shorter than the other, are able to detect single-stranded and double-stranded targets in hybridization reactions and amplification reactions with real-time detection. Double-stranded probes of equal length are useful in PCR amplification reactions with... Agent: The Public Health Research Institute Of The City Of New York, Inc.

20110129838 - Using genetic polymorphisms of the bicd1 gene as a method for determining a risk of developing myopia: A method and kit for determining an increased risk of developing myopia in a subject is provided by detecting an SNP in the BICD1 gene. The SNP is selected from a group consisting of rs10844126 (A/C), rs1151029 (A/T), rs2650122 (C/T), rs10771923 (A/G), rs1151009 (T/C), rs2125173 (A/G) and rs161959 (C/G). When... Agent: Kaohsiung Medical University

20110129841 - Analysis using microfluidic partitioning devices: The invention relates to methods, reagents and devices for detection and characterization of nucleic acids, cells, and other biological samples. Assay method are provided in which a sample is partitioned into sub-samples, and analysis of the contents of the sub-samples carried out. The invention also provides microfluidic devices for conducting... Agent: Fluidigm Corporation

20110129842 - Cyanobacteria saxitoxin gene cluster and detection of cyanotoxic organisms: The present invention relates to methods for the detection of cyanobacteria, dinoflagellates, and in particular, methods for the detection of cyanotoxic organisms. Kits for the detection of cyanobacteria, dinoflagellates, and cyanotoxic organisms are provided. The invention further relates to methods of screening for compounds that modulate the activity of polynucleotides... Agent: Newsouth Innovations Pty Limited

20110129839 - Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed: The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity.... Agent: Universite Libre De Bruxelles

20110129843 - Method for evaluating the virulence of pathogenic biphasic bacteria: A method for evaluating relative bacterial virulence of a biphasic bacteria in environmental systems includes measuring the concentration of DNA in the bacteria, measuring the concentration of RNA in the bacteria, determining a ratio of the concentration of RNA to the concentration of DNA and correlating the concentration ratio with... Agent:

20110129840 - Method, process, and kit for diagnosis or prognosis of colorectal cancer: A process or method and a kit for the diagnosis/prognosis and follow-up of colorectal cancer, which includes a) the extraction of nucleic material from a biological sample, b) use of at least one pair of amplification primers in order to obtain amplicons of at least one target sequence, and c)... Agent: Assistance Publique Hopitaux De Paris

20110129844 - Use of activating transcription factor-2 (atf2) for detecting skin cancer: The present invention is based on the discovery of the tumor suppressor role of activating transcription factor 2 (ATF2) in non-melanoma skin cancer development. Accordingly, the invention provides methods of diagnosing a subject as having or at risk of having skin cancer. Also provided are methods of treating skin cancer... Agent:

20110129845 - Method of diagnosis: The present invention relates generally to a method of diagnosing, predicting and/or monitoring the development or progress of an airway tissue inflammatory response in a mammal. More particularly, the present invention relates to a method of diagnosing, predicting and/or monitoring the development or progress of an airway tissue inflammatory response... Agent: Crc For Asthma And Airways Ltd.

20110129848 - Antibody recognizing g protein, and agent and kit using the same: A novel protein (Gm1) includes an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein α subunits and a trimer forming domain conserved among G protein α subunits. The Gm1 protein... Agent: Sumitomo Chemical Company, Ltd.

20110129849 - Detection of prostate cancer using psa glycosylation patterns: The present invention features novel methods for determining if a subject has prostate cancer. The present invention is based on the development of lectin immunosorbant assays which analyze α2,6-linked sialylation of total serum PSA by sambucus nigra lectin (SNA) and α2,3-linked sialylation of total and free serum PSA. These novel... Agent: The Johns Hopkins University

20110129847 - Microfluidic control chip and method of detecting protein using the same: Provided is a microfluidic control chip, which includes a filter section having a filter to which anti-immunoglobulin antibodies, which are bound to endogenous antibodies in blood to thereby remove the endogenous antibodies, are immobilized, a first reaction section to which detection antibodies immobilized to fluorescent nano-particles are adsorbed, the detection... Agent: Electronics And Telecommunications Research Institute

20110129846 - Photonic biosensor, photonic biosensor array, and method of detecting biomaterials using the same: A photonic biosensor, a photonic biosensor array, and a method of detecting a bio-material using the same are provided. The photonic biosensor includes a light emitting diode configured to emit light, a photodiode (PD), an optical fiber configured to connect the light emitting diode with the PD, and a micro-fluidic... Agent: Electronics And Telecommunications Research Institute

20110129851 - Methods for obtaining bioactive compounds from phytoplankton: Phytoplankton represent a potential source of bioactive compounds. The present disclosure provides, inter alia, methods for identifying glycerolipids and apoptosis-inducing sphingosine-like lipids from virally-infected phytoplankton.... Agent: Rutgers, The State University Of New Jersey

20110129850 - Microfluidic platform for cell culture and assay: A microfluidic chip for at least one of cell culturing and cell assay has a cell culture chamber defined by the microfluidic chip, a first microchannel defined by the microfluidic chip and constructed to provide a fluid path to said cell culture chamber, the microchannel having a pneumatic valve formed... Agent: Ucla Office Of Intellectual Property

20110129856 - Apparatus and method for separating components: An apparatus for separating components and a method of separating components using the apparatus are provided. The apparatus includes: a main chamber which contains a sample that is separated into a plurality of layers by a centrifugal force; a component separating chamber which is connected to the main chamber, and... Agent: Samsung Electronics Co., Ltd.

20110129854 - Assay for diagnosis of cardiac myocyte damage: Assays are disclosed for diagnosing a clinical condition, assessing risk or predicting an outcome as a result of cardiac myocyte damage. Immunoassay methods and kits provide for the assessment of cardiac myocyte damage by determining the presence of multiple cardiac myocyte antigens in a test sample, and combining the multiple... Agent: Abbott Laboratories

20110129855 - Recombinant anti-epidermal growth factor receptor antibody compositions: The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies shown synergy in reduction of proliferation of representative cancer cell lines. Advantageous results... Agent: Symphogen A/s

20110129857 - Methods of detecting or monitoring activity of an inflammatory condition or neurodegenerative condition: An isolated aggrefatin protein elevated in multiple sclerosis patients as compared to healthy controls. Aggrefatin alone or in combination with other markers may be used as an indicator of an inflammatory condition and/or a neurodegenerative disease or condition such as multiple sclerosis, cancer, stroke, or other diseases. Aggrefatin alone or... Agent: Msdx, Inc.

20110129852 - Organic compounds: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for... Agent:

20110129853 - Polysaccharide-protein binding model and nano-fibril formation of a starch binding domain: A polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid residues, and the X2, X3, X4, X5, X6, or X7 means an amino acid residue is described. A mixture for diminising a polysaccharide,... Agent: National Tsing Hua University

20110129859 - Biomarker for diagnosis of liver disease: Disclosed are: a marker for the diagnosis of a liver disease, which can determine the disease in a simple manner; an antibody directed against the marker; a diagnostic agent; a diagnosis method; and a method for marker detection in blood or serum. Proteome analysis revealed that quantities of the full-length... Agent:

20110129860 - Calprotectin and hemoglobin/haptoglobin complex from stool sample to assess colorectal cancer: The present invention relates to a method aiding in the assessment of colorectal cancer. The method especially is used in assessing the absence or presence of colorectal cancer in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a stool sample the concentration of the... Agent:

20110129858 - Prognosis biomarker for evaluating the cure level of stroke patient and a method thereof: A method for evaluating the cure level of a stroke patient comprises following steps: (1) obtaining isolated blood sample from said stroke patient; (2) determining the concentration of serum granulocyte colony-stimulating factor (G-CSF) of said blood sample; (3) comparing the relationship between said concentration of granulocyte colony-stimulating factor (G-CSF) and... Agent: Changhua Christian Hospital

20110129861 - Measurement of anti-ccp and serum amyloid a method to assess rheumatoid arthritis: The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and serum... Agent:

20110129862 - Method for determining cause of the prolongation of blood coagulation time: The method of determining a cause of the prolongation of blood coagulation time in test plasma includes (1) measuring the blood coagulation time of samples including (a) the test plasma only, (b) normal plasma only, and (c) the test plasma and the normal plasma mixed at least at a mixing... Agent: Sekisui Medical Co., Ltd.

20110129868 - Cell capable of replicating novel hcv replicon, cell capable of replicating full-length hcv rna, and use of those cells: According to the present invention, an HCV replicon-replicating cell is produced by a production method including a step of introducing RNA containing an HCV replicon sequence and a selectable marker gene sequence into a Li23 cell or a cured cell derived from a Li23 cell. Further, a full-length HCV RNA-replicating... Agent: National University Corporation Okayama University

20110129867 - Compound screening using chondrocytes: This invention provides a system for obtaining cells of the chondrocyte lineage by differentiating primate pluripotent stem cells. The process involves culturing the cells as a micromass or other aggregate form in a cocktail of differentiation agents that facilitates outgrowth of the desired cell type. Progeny are capable of synthesizing... Agent:

20110129864 - Method for analyzing lymph node aspirate using multi-angle light scatter flow cytometer: Disclosed is a method for identifying lymphatic disease and disease states in mammals. The method uses a multi-angle light scatter flow cytometer to diagnose and treat mammals. The method includes collecting lymph node aspirate from a mammal; scanning the lymph node aspirate in a flow cytometer to generate a diagnostic... Agent: Idexx Laboratories, Inc.

20110129865 - Method for marking materials: The invention relates to a marking system for marking objects wherein said system comprises a microparticle comprising a cross-linked polymer and a marker component wherein the release of said marker component is triggered by contact of the microparticle with an external stimulus and wherein said polymer is a carbohydrate or... Agent: Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno

20110129863 - Methods and systems for processing samples on porous substrates: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least... Agent: General Electric Company

20110129866 - Novel tissue culture platform for screening of potential bone remodeling agents: The present disclosure provides methods for identifying candidate compounds having bone anti-resorption activity or bone pro-formation activity. The methods involve the use of ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions in the presence of the... Agent: Osteosphere, LLC

20110129869 - Selective enrichment medium for carbapenem-resistant bacteria: The present invention relates to a method for direct detection and differentiation of carbapenem-resistant bacteria in a sample comprising (i) inoculation with said sample of a culture medium comprising at least meropenem and/or ertapenem and at least one chromogenic agent, (ii) incubation of said culture medium under conditions allowing the... Agent:

20110129870 - Microbial screen test: A method for testing a microbial population including a negative screen includes inoculating a plurality of test ampoules with respective samples and recording a time of the inoculation (102a), performing a first light transmittance test on the test ampoules (103a), recording first test data, performing a second light transmittance test... Agent:

20110129871 - Culture medium enabling staphylococcus aureus to be differentiated from coagulase-negative staphylococci: A specific culture medium for growth, detection, identification and/or counting of Staphylococcus aureus bacteria, said medium includes at least one fluorogenic, chromogenic or luminescent substrate of phospholipase C. Said medium permits differentiation between Staphylococcus aureus and coagulase-negative staphylococci.... Agent: Biomerieux

20110129872 - Method for a production of a recombinant protein using yeast co-expression system: The present invention relates to a method for mass production of a recombinant protein comprising the step of culturing a yeast transformed with: a recombinant gene construct comprising a yeast promoter, a gene coding a signal sequence and a gene coding a target protein; and also with one or more... Agent: Mogam Biotechnology Research Institute

20110129874 - Pichia pastoris das promoter variants: The present invention relates to promoter variants in the form of an isolated polynucleotide comprising: i) a nucleotide sequence consisting of the DAS promoter sequence from Pichia or a functional part thereof, wherein the said DAS promoter is contained in SEQ ID NO: 1; and ii) at least one additional... Agent: Novozymes A/s

20110129873 - Recombinant dna vectors for expression of human prolactin antagonists: Embodiments of the present invention relate generally to methods and compositions for producing human prolactin antagonists. Embodiments of the present invention also relate to various methods for improved production of human prolactin antagonists by microorganisms. These microorganisms, including Escherichia coli, can be transformed to enable the expression of human prolactin... Agent: Monsanto Technology LLC

20110129876 - Constructs and methods for the production and secretion of polypeptides: Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the... Agent: L'instutut National Des Sciences Appliquees (insa)

20110129875 - Immunosupprressive polypeptides and nucleic acids: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.... Agent: Perseid Therapeutics LLC

20110129877 - Pullulanase variants and methods for preparing such variants with predetermined properties: The present invention relates to pullulanase variants, wherein the variants have improved properties, for example, altered pH optimum, improved thermostability, altered substrate specificity, increased specific activity or altered cleavage pattern.... Agent: Novozymes A/s

20110129878 - Bioreactive agents: This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents... Agent: The Trustees Of Boston University

20110129879 - Hybrid genes and enzymes of glucanase and dextransucrase and processes for preparing isomalto-oligosaccharides or dextran using the same: Disclosed are hybrid genes of glucanase and dextransucrase, recombinant vectors comprising said hybrid genes, microorganisms which are transformed with said recombinant vectors, hybrid enzymes which are expressed from said hybrid genes, and processes for preparing isomalto-oligosaccharides or dextran using said microorganisms or enzymes. Expensive isomalto-oligosaccharides and low molecular weight dextran... Agent: Industry Foundation Of Chonnam National University

20110129880 - Process for treating biomass to increase accessibility of polysaccarides contained therein to hydrolysis and subsequent fermentation, and polysaccharides with increased accessibility: In this invention, a process for producing fermentable sugars derivable from biomass that contains polysaccharide, such as cellulose, which has been made increasingly accessible as a substrate for enzymatic degradation or other methods of depolymerization. The process of the present invention increases accessibility of polysaccharides, typically present in biomass and... Agent: Hercules Incorporated

20110129881 - Recombinant beta-glucosidase variants for production of soluble sugars from cellulosic biomass: The invention relates to recombinant expression of a variant form of a fungal C1 strain β-glucosidase. The invention also relates to the generation of fermentable sugars from biomass and the production of biofuels by fermentation of the sugars using genetically modified organisms expressing the β-glucosidase variant. The invention provides methods... Agent:

20110129882 - Gene coding for glucose-6-phosphate-dehydrogenase proteins: The present invention relates to isolated nucleic acid molecules encoding mutants of glucose-6-phosphate dehydrogenase, and vectors and hosts cells including such nucleic acid molecules. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., an amino acid such as lysine. The present invention also relates to... Agent: Basf Se

20110129883 - Inactivation of genes of the mep pathway: The invention relates to cells and organisms as well as to methods for producing said cells and organisms, according to which intermediates of the mevalonate-independent pathway for isoprenoid biosynthesis (MEP pathway) are enriched by deleting or inactivating genes. The derivatives can also be enriched by using enzyme inhibitors. The enriched... Agent: Bioagency Ag

20110129884 - Method for the cultivation of microorganisms of the order thraustochytriales: The present invention relates generally to the field of microorganism cell culture. It devises a cell culture medium for and a method of culturing microorganisms of the order Thraustochytriales, especially for the production of omega-3-fatty acids. Furthermore it devises the use of ammonium tartrate as nitrogen source for the cultivation... Agent:

20110129885 - Microorganism for the production of succinic acid: The invention relates to an isolated genetically modified microorganism in which the gene IDH1 and at least one of the genes SDH2 and DIC1 are under the control of a first promoter that is repressed to a growth culture medium by means of a cultivation additive and is active in... Agent: Organo-balance Gmbh

20110129886 - Biorefinery process for extraction, separation, and recovery of fermentable saccharides, other useful compounds, and yield of improved lignocellulosic material from plant biomass: Non-food plant biomass is subjected to hot-water extraction in a pressurized vessel at an elevated temperature up to about 250° C. and at a pH below about 7.0, to yield an aqueous extract containing hemicellulosic components, other wood-derived compounds, and a lignocellulosic residue. The separated aqueous extract or liquor is... Agent: Applied Biorefinery Sciences LLC.

20110129887 - Immobilized product tolerant microorganisms: Methods for adapting or selecting microorganisms with increased product tolerance are provided Additionally, a bioreactor capable of operation in either packed bed or fluidized bed is disclosed along with methods to use the bioreactor for culturing microorganisms adapted or selected increased product tolerance... Agent:

20110129888 - Method for fermenting cellulosics: The present invention is directed to host cells capable of fermenting cellulosic materials for the production of ethanol. Microorganisms engineered to be able to use amorphous cellulosic materials in a fermentation process to produce ethanol are disclosed. Additionally, methods of using the host organisms of the invention and compositions for... Agent: Stellenbosch University

20110129890 - Method of treating substance containing lignocellulose or cellulose: A method for converting a material comprising lignocellulose or cellulose into a substance convertible with yeast into ethyl alcohol, wherein a mixture comprising 1 part by weight of the material and 0.5 to 5 parts by weight of water is stirred at a temperature of 150 to 270 degrees C.... Agent: K.e.m. Corporation

20110129889 - Process for production of ethanol from lignocellulosic material: This invention relates to a process for production of ethanol from lignocellulosic material. Lignocellulosic material treated with a dicarboxylic acid, preferably with oxalic acid, separating a hemicellulosic fraction to ferment pentose sugar. The lignin is dissolved in alkali, preferably with NaOH, separating a cellulose fraction for further enzymatic treatment with... Agent: Praj Industries Limited

20110129891 - Process for controlled homogeneous acid leaching: A method for leaching a material containing one or more target metals using an acidic leaching solution to extract said one or more target metals, said method including (I) empirically determining an optimal acid concentration range for said acidic leaching solution by: (a) determining the relationship between the concentration of... Agent:

20110129892 - Production of cell tissue having three-dimensional structure using electrostatic ink jet phenomenon: a voltage applying unit for applying a voltage to the vessel, wherein a voltage is applied to the vessel by the voltage applying unit in order to generate an electric field between the vessel and the substrate, causing the solution to be ejected from the vessel as a result of... Agent: Riken

20110129893 - Monitoring target endogenous species: An electrode comprising: a conducting substrate for detecting an electroactive agent; a catalytic agent held on the substrate for converting a non-electroactive agent to an electroactive agent by a catalytic process which consumes oxygen; and an oxygen reservoir, for releasing oxygen to feed the catalytic process, held within a polymer... Agent: National Universtiy Of Ireland, Maynooth

20110129894 - Secretion optimized microorganism: Proteins having a cofactor can be secreted in an improved manner in a microorganism belonging to the genus Corynebacterium provided that the microorganism contains a nucleic acid sequence which is not naturally present in it and which comprises at least the following sequence sections: a) nucleic acid sequence coding for... Agent:

20110129895 - Method for purifying protein: A method is provided for purifying protein having steps of loading a sample containing proteins into a column containing an ion exchanger in a first direction to allow the ion exchanger to absorb proteins; and passing a salt solution through the column in a second direction opposite to the first... Agent: Tamkang University

20110129896 - Inhibitors of gsk-3 and crystal structures of gsk-3beta protein and protein complexes: The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules... Agent: Vertex Pharmaceuticals Incorporated

20110129898 - Methods and compositions for increasing nuclease activity: Disclosed herein are methods and compositions for increasing nuclease activity to increase nuclease-mediated genomic modifications.... Agent:

20110129897 - Process for making micro-sized protein particles: A process of making micro-sized protein particles comprising the step of drying nano-sized protein particles suspended in a liquid medium under conditions to agglomerate the nano-sized protein particles and thereby form micro-sized protein particles.... Agent:

20110129900 - Low oxygen biologically mediated nutrient removal: The present invention is directed to a substantially odorless biologically mediated treatment process for solid and liquid organic wastes. The present invention also provides for a novel nutrient rich humus material produced from the biologically mediated treatment process. The bioconversion process of the present invention results from low electron acceptor... Agent:

20110129899 - Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of... Agent:

20110129901 - Use of a carbonaceous substitute for the production of yeast: The present invention relates to novel strains of Saccharomyces that can be produced on a carbonaceous substrate which makes it possible to completely and/or partially replace the use of sugar, and to the use thereof for the production of yeast, in particular on the industrial scale. The invention also relates... Agent: Lesaffre Et Compagnie

20110129903 - Method of making an artificial micro-gland using taxis: A method is used for making an artificial micro-gland by taxis. A monodisperse multiple emulsion is produced with a first fluid; a second fluid confined within the first fluid; a third fluid within the second fluid. Interfaces between the fluids permit living cells dispersed in the one of the fluids... Agent:

20110129902 - Microbial strain alteromonas sp. sn2 for degrading polycyclic aromatic hydrocarbon: The present invention relates to a novel microbial strain, Alteromonas sp. SN2 (KCTC11700BP) having an activity for degrading polycyclic aromatic hydrocarbon (PAH), a bioremediation process of polycyclic aromatic hydrocarbon (PAH) contaminants, comprising contacting a microbial strain Alteromonas sp. with PAH, and a composition for purifying polycyclic aromatic hydrocarbon (PAH) contaminants,... Agent: Chung-ang University Industry-academy Cooperation Foundation

20110129904 - Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol: A non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway includes at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme or protein expressed in a sufficient amount to produce 1,3-BDO. A method for producing 1,3-BDO that includes culturing the this non-naturally occurring microbial organism under conditions and for... Agent:

20110129905 - Modified pichia strain: The present invention generally relates to a modified strain of yeast. More specifically, it relates to a strain of Pichia pastoris, deficient in its native yeast aquaporin Aqy1 or expressing non-functional Aqy1, as well as related methods and uses. In a first aspect, the present invention comprises a strain of... Agent:

20110129906 - Photobioreactor, system and method for the cultivation of photosynthetic microorganisms: The present invention relates to the cultivation of photosynthetic microorganisms, and more particularly, to a low-cost flexible photobioreactor (1), as well as systems and methods using the same for optimizing the growth of microalgal species. The photobioreactor of the invention is in the shape of a flexible transparent elongated body... Agent:

20110129907 - Method of conversion of biodegradable, hygienically non-stabilized substrate into hygienically stabilized product: A method for treating hygienically unstable waste is disclosed. Waste is allowed to aerobically ferment for approximately 36 hours at a temperature of 40 to 50° C. During aerobic fermentation, an external air supply maintains the appropriate temperature, while restacking of the substrate ensures uniform oxygen distribution. After approximately 36... Agent: Agro-eko Spol.

20110129908 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Lifeline Scientific, Inc.

20110129909 - Liquid sample analysis device: A liquid sample analysis device includes a holder part 11 holding a test piece 1, an optical system 20 that optically detects a reaction state of a liquid sample and a reagent, and a support member 30 that integrally supports the holder part 11 and the optical system 20. The... Agent: Panasonic Corporation

20110129911 - Bioreactor chamber: Embodiments of the invention provide a chamber for a bioreactor, the chamber having a fluid inlet aperture and a fluid outlet aperture disposed at respective different locations of a wall of the chamber, with respect to a normal upright orientation of the chamber the chamber being provided with an upper... Agent:

20110129910 - Cooling device, and assembly, and methods for lowering temperature in a chemical reaction: Embodiments provide a cooling device. The cooling device comprises a container configured as a heat sink. The container is at least partially made from heat conducting material. The cooling device further comprises endothermic chemical material which is contained in the container.... Agent: Agency For Science, Technology And Research

20110129912 - Selective conformation of cell culturing support layer: Embodiments described herein relate to in vitro cell culture. Embodiments include a substrate having a support layer that includes support molecules having a first region configured to bind to the substrate and having a photo-responsive region configured to change conformation between at least two conformations. In a first conformation of... Agent: Empire Technology Development LLC

20110129913 - Device for cell culture: The device for cell culture comprises: a container body (2) which has an internal compartment (5) to contain a quantity of cells to be cultured and a culture surface (3A; 120) for said cells placed in said internal compartment (5); an introduction opening (6; 106) for introducing said cells to... Agent: Rigenerand Srl

20110129914 - Thermocycling of a block comprising multiple sample: The present invention relates to the field of high throughput analysis of samples. In particular, the present invention is directed to a device, a system and a method for simultaneous tempering of multiple samples. More particular, the invention relates to the simultaneous thermocycling of multiple samples to perform PCR in... Agent: Roche Diagnostics Operations, Inc.

20110129915 - Apparatus and method for incubating cell cultures: A portable, self-contained incubation apparatus has a cell container in which a cell culture can grow. The cell container resides on a base along with other components that maintain the environmental conditions inside of the container within a desired range. The self-contained incubation apparatus is portable allowing the conditions within... Agent:

20110129916 - Monoclonal antibodies with specificity for fetal erythroid cells: The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.... Agent:

20110129917 - Cell isolation method: The present invention is a method for isolating a desired cell, which comprises selectively applying culture conditions including a culture medium to a sample potentially containing various cells, with addition of a cell enlarger simultaneously with, before or after the application. Thereby, it is possible to conveniently and efficiently obtain... Agent:

20110129918 - Method for expanding mesenchymal stem cells in low-density and hypoxic culture: The present invention relates to a novel method for expanding mesenchymal stem cells (MSCs) in low-density and hypoxic condition as compared to normal air conditions traditionally used in cell culture. The present method provides rapid and efficient expansion of human MSCs without losing cellular proliferation and stem cell properties, including... Agent:

20110129919 - Microcarriers for stem cell culture: We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50... Agent: Agency For Science, Technology And Research

20110129920 - Biomarkers for alzheimer's disease: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Alzheimer's dementia or normal. The biomarkers can be detected by SELDI mass... Agent: Vermillion, Inc.

20110129921 - Targeted polymer bioconjugates: Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer.... Agent: Phaserx, Inc.

20110129922 - Method for inducing differentiation into cardiomyocytes using g-csf: A method for inducing differentiation of ES cells into cardiomyocytes, which comprises contacting the ES cells with an agonist for G-CSF receptor.... Agent: Keiichi Fukuda

20110129923 - Cell culture methods and devices utilizing gas permeable materials: Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.... Agent:

20110129924 - Porous polymeric articles: Porous polymeric articles, and more specifically, porous polymeric articles for tissue engineering and organ replacement, are described. In some embodiments, methods described herein include use of a polymer-solvent system (e.g., phase inversion) to generate porosity in a structure. The process may include formation of a structure precursor material including a... Agent: Agency For Science, Technology And Research

20110129925 - Zeolite and bone mimetic zeolite based coatings for bioimplants: The disclosure provides biocompatible metal compositions, methods of making such compositions and uses thereof, including a method of synthesizing zeolite coatings. The disclosure further provides the zeolite-hydroxyapatite composite coatings and methods of making them, which includes forming a base zeolite layer, forming a hydroxyapatite layer on the base zeolite layer,... Agent:

20110129926 - Dry powder cell culture products and methods of production thereof: The present invention relates to nutritive medium, medium supplement, media subgroup and buffer formulations. The present invention provides powder nutritive medium, medium supplement and medium subgroup formulations, e.g., cell culture medium supplements (including powdered sera such as powdered fetal bovine serum (FBS)), medium subgroup formulations and cell culture media comprising... Agent: Life Technologies Corporation

20110129927 - Chinese hamster apoptosis-related genes: Provided is an isolated polypeptide comprising a Cricetulus griseus sequence capable of mediating apoptosis of a cell, the sequence being selected from a FAIM sequence shown as SEQ ID NO: 1; a FADD sequence shown as SEQ ID NO: 2; a PDCD6 sequence shown as SEQ ID NO: 3; and... Agent: Agency For Science, Technology And Research

20110129928 - Method of manufacturing induced pluripotent stem cell originated from somatic cell: Disclosed is a method for manufacturing stem cells including preparing Oct-4 gene, Sox2 gene, C-myc gene, and Klf-4 gene from mouse embryonic stem cells, and allowing each of the genes to be infected in host cells using a lentiviral vector system to generate viruses in which each of the genes... Agent: Mirae Biotech Co., Ltd.

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