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Chemistry: molecular biology and microbiology April category listing, related patent applications 04/11

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
04/28/2011 > patent applications in patent subcategories. category listing, related patent applications

20110097700 - Methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood: Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce... Agent: Cytosorbents, Inc., Stefan Brodie, Donald Brodie

20110097701 - Hcn removal from syngas using chemical and biological treatment: A method for the high removal of ammonia and HCN from syngas in a cost effective and environmentally benign and sustainable fashion, with the need for minimal chemical addition by using a combination of water based gas scrubbing, HCN scrubbing and biological processing steps.... Agent:

20110097708 - Assessment of human papilloma virus-related disease: This invention provides novel methods for assessing HPV infection. Gene expression levels are used to assess the progression of HPV infection from benign to malignant growth. Also provided are kits for carrying out the methods of this invention.... Agent: Qiagen Gaithersburg Inc.

20110097704 - Compositions for use in identification of picornaviruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the Picornaviridae family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Ibis Biosciences, Inc.

20110097703 - Method for carrying out a qualitative preliminary instant diagnosis of oncologic diseases: The invention relates to medicine, in particular to a method for carrying out a preliminary instant diagnosis of oncologic diseases. The method involves sampling a patient's blood, mixing the sample with a reagent and recording reaction results. A supernatant liquid, which is produced by cultivating the finite cell line of... Agent:

20110097702 - Methods and compositions for in situ detection of microorganisms on a surface: Compositions and methods for in situ detection of one or more target microorganisms on a surface and preferably on a hard surface. Compositions and methods of the invention are based on the specificity of certain bacteriophage for target microorganisms. Bacteriophage are modified to express detectable biomarkers in the presence of... Agent:

20110097706 - Micro-reactor for observing particles in a fluid: The micro-reactor may be used with an optical microscope (in which all particles are in focus), inspection with a Scanning Transmission Electron Microscope (in which the range of the electrons is limited), inspection with soft X-rays in the 250-500 eV range (also showing a limited range), etc. A method of... Agent: Stichting Het Nederlands Kanker Instituut

20110097707 - Rnai agents comprising universal nucleobases: One aspect of the present invention relates to an oligonucleotide agent comprising at least one universal nucleobase. In certain embodiments, the universal nucleobase is difluorotolyl, nitroindolyl, nitropyrrolyl, or nitroimidazolyl. In a preferred embodiment, the universal nucleobase is difluorotolyl. In certain embodiments, the oligonucleotide is double-stranded. In certain embodiments, the oligonucleotide... Agent: Alnylam Pharmaceuticals, Inc.

20110097705 - Surface-assisted hemagglutination and hemagglutination inhibition assays: Hemagglutination (HA) and hemagglutination inhibition (HAI) functional assays remain important instruments of analysis of virus-cell interaction and protecting efficacy of virus-specific antibodies and sera. However, they demonstrate limited sensitivity towards many viruses, and require significant volumes of viruses, erythrocytes, sera, and antibodies. The present invention comprises new and significantly more... Agent: Vaxdesign Corp.

20110097714 - Amplification method of methylated or unmethylated nucleic acid: The object of the present invention is to provide a gene amplification method, wherein the method can amplify both methylated and unmethylated nucleic acids present in a biological sample, and further regulate the amplification ratio of the methylated and/or unmethylated nucleic acid as needed. Such objects can be solved by... Agent: Bio-dixam LLC

20110097729 - Apparatus and method for sequencing nucleic acid molecules: e

20110097722 - Cold shock protein compositions and methods and kits for the use thereof: The present invention provides cold shock protein-containing compositions for improved DNA synthesis reactions with improved reactivity, methods for synthesizing DNA using such compositions, kits for use in such methods, and DNA compositions yielded by such methods. The present invention further provides cold shock protein-containing compositions for the identification of endoribonuclease... Agent: University Of Medicine And Dentistry Of New Jersey

20110097713 - Compositions and methods for pharmacogenomic screening of cyp2c9 and vkorc1: Compositions and methods for determining an optimal dose of a medication for a subject are described that include determining the subject's genotype for the CYP2C9 and VKORC1 genes and determining the dose of the medication based on the genotype. Articles of manufacture also are provided that include polynucleotides for genotyping.... Agent: Catalyst Assets LLC

20110097724 - Detection of head and neck cancer using hypermethylated gene detection: Methods and kits for detection of a cell proliferative disorder, such as head and neck cancer are provided utilizing analysis of the methylation state of targeted genes or regulatory regions of genes in a saliva or serum sample are described. The presence of hypermethylation of the genes or their regulatory... Agent: The Johns Hopkins University

20110097727 - Dna markers for management of cancer: A method is provided for assessing allelic losses and hypermethylation of genes in CpG tumor promotor region on specific chromosomal regions in cancer patients, including melanoma, neuroblastoma breast, colorectal, and prostate cancer patients. The method relies on the evidence that free DNA and hypermethylation of genes in CpG tumor promotor... Agent:

20110097717 - Gene expression profiling for identification of cancer: A method is provided for determining whether an individual has a particular cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least 1 constituent from Tables A-C.... Agent:

20110097721 - In vivo gene sensors: Described are methods and compositions for the detection of target genes. The inventors have developed a synthetic nucleic acid sensor-effector gene circuit. In cells without a target gene, the circuit suppresses e.g., effector production, but in the presence of the target gene the suppression is subject to competition, such that... Agent: Massachusetts Institute Of Technology

20110097728 - Materials and method for assaying for methylation of cpg islands associated with genes in the evaluation of cancer: Provided are methods, reagents, and kits for evaluating cancer, such as prostate cancer, in a subject. Disclosed methods of evaluating cancer include methods of diagnosing cancer, methods of prognosticating cancer and methods of assessing the efficacy of cancer treatment. The methods include assaying a biological sample for methylation of a... Agent: Euclid Diagnostics LLC

20110097712 - Method for detecting and quantifying rare mutations/polymorphisms: The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare mutation can be any type of functional or non-functional nucleic acid change or mutation, such as deletion,... Agent: Trustees Of Boston University

20110097709 - Method for modifying a nucleic acid: Disclosed are methods for increasing the rate at which a nucleic acid can be translated by modifying the polynucleotide such that the rate at which the polynucleotide is translated is altered. Also disclosed are methods for modulating the translation of an mRNA by adding a nucleic acid that increases translation... Agent:

20110097715 - Method for purifying or detecting a target protein: A method for purifying or detecting a target protein present in a solution, includes, before carrying out the actual detection or purification step, a step of contacting the solution with an aptamer binding specifically to the target protein, where the aptamer does not bind to a protein homologous to the... Agent: Lfb - Biotechnologies

20110097711 - Method of judging inflammatory disease by using single nucleotdie polymorphism: An object of the present invention is to identify a novel single nucleotide polymorphism (SNP) associated with the onset and the advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging an inflammatory disease which comprises detecting at least 1 type of genetic polymorphism... Agent: Riken

20110097723 - Methods and reagents for analyte detection: The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using chemiluminescent and fluorescent molecule/enzyme coupled with analyte binding molecules to detect specific analyte molecules. Another aspect of the current invention is to use gold nanoparticle triggered chemiluminescent reaction to... Agent:

20110097710 - Methods for detecting atrial fibrillation and related conditions: Methods for detecting disorders associated with atrial fibrillation, and, thus, at risk for stroke and/or heart failure) in a subject based on a monitoring plasma levels of apelin are provided. Diagnostic compositions for the detection of such disorders are additionally provided.... Agent:

20110097716 - Methods for detecting oligonucleotides: The invention provides methods and compositions for detecting and/or quantifying nucleic acid oligonucleotides. These methods and compositions are useful for detecting and quantifying diagnostic and/or therapeutic synthetic target oligonucleotides, such as aptamers, RNAi, siRNA, antisense oligonucleotides or ribozymes in a biological sample.... Agent: Novartis Ag

20110097718 - Ms-compatible nonionic or zwitterionic surfactants in free-flow electrophoresis: The invention relates to the use of MS compatible surfactants in free-flow electrophoretic methods, which allow the separation of analytes with differentiated electrophoretic mobility. The surfactant is preferably a cleavable surfactant, such as PPS.... Agent: Becton, Dickinson And Company

20110097719 - Neprilysin gene polymorphism and amyloid beta plaques in traumatic brain injury: The invention relates to methods of diagnosing risk of amyloid β deposition following traumatic brain injury. More particularly, the invention relates to the discovery of a specific single nucleotide polymorphism in the neprilysin gene that is linked to an increased risk of amyloid β deposition after traumatic brain injury... Agent: The Trustees Of The University Of Pennsylvania

20110097731 - Novel mitochondrial dye: The present invention relates to the use of single-barrel genetically encoded GFP-based calcium indicator as an intramitochondrial dye and to nucleic acid molecules coding for said indicators, as well as to methods using said indicators. Examples of single-barrel genetically encoded GFP-based calcium indicator is a GCaMP, Case16 and/or Case12. In... Agent: Novartis Forschungsstiftung, Zweigniederlassung Friedrich Mischer Institute For Biomedical Researc

20110097725 - Rapid detection of mycobacteria: The invention provides a method for detecting a mycobacterium belonging to the MTB complex in a sample, the method comprising: (a) contacting the sample with a pair of forward and reverse oligonucleotide primers; wherein said forward primer hybridises to a target nucleic acid sequence located within a Mycobacterial Interspersed Repetitive... Agent: Health Protection Agency

20110097730 - Recombinant sars-cov nsp12 and the use of thereof and the method for producing it: The present invention relates to a recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) non-structural protein (nsp) 12 with an RNA polymerase activity, its expression vector, its preparation method, and its use. According to the present invention, a soluble recombinant SARS-CoV nsp12 with an RdRp activity of initiating SARS-CoV genome synthesis... Agent: Kookmin University Industry Academy Cooperation Foundation

20110097726 - Regeneration and neogenesis of retinal photoreceptor cell using otx2 gene: The present invention provides a medicine, comprising (a) an Otx2 protein or its partial peptide, or a salt thereof, or (b) a DNA or an RNA encoding an Otx2 protein or its partial peptide. The present medicine is useful as an agent for preventing, treating or suppressing progression of a... Agent:

20110097720 - Screening method for selected amino lipid-containing compositions: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.... Agent: Alnylam Pharmaceuticals, Inc.

20110097734 - Flow control technique for assay devices: A method for controlling fluid flow in an assay device that employs a membrane is provided. Specifically, one or more recessed regions are formed in the membrane by applying a solvent treatment thereto. The solvent treatment is selected based on its particular dissolving capacity for the material used to form... Agent: Kimberly-clark Worldwide, Inc.

20110097732 - Novel biomarker for the prognosis of breast cancer: The present invention relates to methods of determining the predilection for survival for an individual having breast cancer comprising: obtaining a breast tissue sample from said individual, measuring the amount of Wrap53 in the nucleus of cells in said breast tissue sample, and/or measuring the amount of Wrap53 in the... Agent: Medinnova As

20110097733 - Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite: The invention concerns a process for the production of a hybridoma, and of a monoclonal antibody or fragments thereof able to recognize 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3.... Agent:

20110097735 - Fluorescent pyrene compounds: The present invention relates to fluorescent pyrene dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for... Agent: Biotium, Inc.

20110097742 - Contrast agents, methods for preparing contrast agents, and methods of imaging: Embodiments of the present disclosure provide for contrast agents, methods of making contrast agents, and methods of using contrast agents, and the like.... Agent:

20110097741 - Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays: A novel sweet receptor protein, corresponding nucleic acid sequence, expression vectors, transfected host cells, and screening methods for modulators including ligands of the sweet taste response employing the aforementioned are provided.... Agent:

20110097743 - Compositions and methods of detecting tiabs: The present invention relates to novel methods and products for assessing the physiological status of a subject. More particularly, the invention relates to methods of assessing the presence, risk or stage of a cancer in a subject by measuring the levels of antibodies against particular aberrant protein domains in a... Agent: Transmedi Sa

20110097744 - Cellular copd diagnosis: Method for diagnosing the risk of a human subject to develop chronic obstructive pulmonary disease (COPD) comprising the steps of:—providing a sample from a human subject,—determining the amount of CD4+CD28null T-cells in said sample,—diagnosing the risk to develop COPD when the amount of CD4+CD28null T-cells is reduced compared to the... Agent: Aposcience Ag

20110097745 - Method for detecting microbes: The invention provides means and methods for determining the presence of infecting microbes in a liquid. The method comprises steps of introducing the liquid to the sample container of a microbial analyzer, the sample container further containing nutrients. Other steps include carrying out a first incubation of said specimen, adding... Agent: Check Light Ltd.

20110097737 - Methods and compositions for targeting proteins of interest to the host cell envelope: Methods and compositions are provided for producing membrane proteins or toxic proteins from recombinant DNA introduced into a prokaryotic host cell by targeting the expressed proteins to the envelope of the host cell. The methods and compositions utilize a protein vehicle fused to a protein of interest. The fusion protein... Agent: New England Biolabs, Inc.

20110097736 - Methods of determining levels of free amino acid and dipeptides and diagnosing alzheimer's diseases: Provided herein are methods of diagnosing Alzheimer's disease (“AD”) based on characteristic changes of the levels of certain free amino acids or dipeptides (collectively termed as “AD diagnosis markers”) in the body fluid sample of an individual, carnosine synthesis activities in the plasma, and dopamine synthesis activities in the plasma.... Agent: Huntington Medical Research Institute

20110097738 - Plasma biomarker tool for the diagnosis of liver cancer comprising liver carboxylesterase 1 and liver cancer screening method: The present invention relates to a plasma biomarker for diagnosing hepatocellular carcinoma (HCC), in particular to the discovery of a protein in plasma using 2-D fluorescence differential gel electrophoresis (2-D DIGE), immunoprecipitation and Nano-liquid chromatography mass spectrometry (Nano-LC-MS/MS) system that was unknown on the basis of conventional techniques. By demonstrating... Agent:

20110097739 - Blood-brain barrier epitopes and uses thereof: The invention features a method of identifying an agent and generating an antibody that can cross the blood brain barrier, through the use of novel antigen isoforms of transmembrane domain protein 30A (TMEM30A). This is useful in establishing mechanisms of transmigration across the blood-brain barrier. These antigens are enriched in... Agent:

20110097740 - Real-time continuous detection device: Provided is a real-time continuous detection device for detecting an analyte in a sample including: a sample inflow channel; a sample assay site; and a sample outflow channel, wherein the sample assay site includes a reversible capturing recognizing component and a sensor which detects a signal generated from a binding... Agent: Korea University Research And Business Foundation

20110097752 - Copd diagnosis: The present invention relates to a method for diagnosing chronic obstructive pulmonary disease (COPD) in a human subject or the risk of a human subject to develop COPD comprising the steps of: —providing a sample from a human subject, —determining the amount of caspase-cleaved cytokeratin-18 (ccCK-18), histones, heat shock protein... Agent: Aposcience Ag

20110097751 - Glp-1 receptor agonist bioassays: Provided herein are cell-based bioassays for measuring GLP-I receptor agonist activity of test compounds, such as GLP-I receptor agonist compounds. Exemplary GLP-I receptor agonist compounds include exendins, exendin analogs, GLP-1(7-37), and GLP-1(7-37) analogs. The bioassays are useful for quantitatively determining cAMP generated in samples containing GLP-I receptor agonist compounds (e.g.,... Agent: Amylin Pharmaceuticals, Inc.

20110097750 - Method of quantitative assessment on reproductive effort of black-lip pearl oysters using antibody specific thereto: Disclosed are an antigen protein of black-lip pearl oyster egg extract, an antibody specific thereto, and a method of quantitative assessment of the reproductive effort of black-lip pearl oyster using the antibody. The method accomplishes quantitative assessment of reproductive effort of black-lip pearl oysters easily and accurately. In addition, the... Agent: Korea Ocean Research And Development Institute

20110097747 - Monoclonal antibody binds antigen associated with human tumors: The present invention is concerned with a novel antigen associated with human tumors, including carcinomas of the colon, pancreas, and lung, as well as novel monoclonal antibodies which binds strongly to said antigen. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The... Agent:

20110097746 - Orthogonal method for the removal of transmissible spongiform encephalopathy agents from biological fluids: A method comprising contacting a biological fluid comprising hemoglobin and at least one pathogenic agent with a first filter and generating a first filtrate; contacting the first filtrate with a nanofiltration device and generating a second filtrate; contacting the second filtrate with a chromatographic material and isolating an eluted fraction;... Agent: Texas Tech University

20110097749 - Process for producing hepcidin: The present invention provides a novel method for producing biologically functional hepcidin in Pichia pastoris. The invention further provides novel tagged hepcidin, antibodies and their uses in therapy and immunoassays.... Agent: Hellenic Pasteur Institute

20110097748 - Use of cell lines to determine levels of efficacy of pharmaceutical formulations: The present invention provides methods and assays for determining the efficacy of pharmaceutical compositions. Through the use of cell lines to measure efficacy of a formulation, one can better measure characteristics such as half life, release rate and release profile of a product that may be informative to the FDA.... Agent: Warsaw Orthopedic, Inc.

20110097753 - Chemiluminescent methods and reagents for analyte detection: The present invention relates to chemiluminescent method and regent to detect analyte. One aspect of the current invention relates to using enzyme substrate that can be cleaved by target enzyme to release chemiluminescent compound giving light signal for the detection of varieties of target enzymes. Another aspect of the current... Agent:

20110097754 - Method for measuring activated factor vii level in a sample: The present disclosure relates to a method for measuring the activated factor VII level in a sample to be tested, including the steps of: a) mixing the test sample with a plasma free of factor VII (FVII) and free of at least another factor selected from among factor VIII (FVIII),... Agent: Lfb Biotechnologies

20110097755 - Apparatus and method for optically sensing analyte concentration in an erythrocyte-containing fluid: A device for determination of analytes has optical material with a deposit on a surface thereof. The deposit includes an analyte-reactive reagent and a particulate material for enhancing reflectance of a light beam emitted through the optical material into the analyte-reactive reagent. The enhanced reflectance provides a return of light... Agent:

20110097756 - Apex as a marker for lung cancer: The present invention relates to the assessment of lung cancer. It discloses the use of protein AP endonuclease (APEX) in the assessment of lung cancer. It also relates to a method for assessing lung cancer in vitro using a liquid sample derived from an individual by measuring APEX in the... Agent:

20110097757 - Biomarkers for diabetes, obesity, and/or hypertension: Methods of identifying subjects having, or at risk of developing, diabetes, obesity, and/or hypertension are disclosed, as well as methods of identifying biomarkers for diabetes, obesity, and/or hypertension, and biomarkers identified by such methods.... Agent: Northeastern University

20110097758 - Peptide conjugates and fluorescence detection methods for intracellular caspase assay: Polypeptides labelled with a donor and acceptor pair of dyes selected from a dibenzorhodamine dye and a diamino-benzophenoxazine dye are peptide conjugates which are useful for intracellular and bead-based assays with fluorescence detection. Peptide conjugates with a caspase-recognition site undergo cleavage into peptide fragments which may be detected, located, and... Agent: Life Technologies Corporation

20110097759 - Gene expression markers for colorectal cancer prognosis: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.... Agent:

20110097760 - Method for producing a casein hydrolysate: The present invention relates to a method for producing a casein hydrolysate using a microbial endopeptidase.... Agent: Novozymes A/s

20110097761 - Mutant muscle-specific enhancers: The present invention relates to nucleic acid compositions and expression systems comprising muscle-specific regulatory elements, and methods for expressing heterologous DNA sequences in cells. In particular, the present invention provides mutant muscle-specific enhancers, genetic cassettes, and vectors useful in gene therapy, diagnostic assays, and other gene expression systems.... Agent:

20110097762 - Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide... Agent: The Regents Of The Unversity Of Michigan

20110097763 - Thermal cycling method: The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one application, droplet actuators are used to conduct genetic analysis using polymerase chain reaction (PCR) techniques. The invention addresses the need... Agent: Advanced Liquid Logic, Inc.

20110097764 - Amplification primers with non-standard bases for increased reaction specificity: Described herein are methods for increasing the annealing specificity of an amplification reaction using Iso-base Amplification Primers (“IAPs”). IAPs containing an iso-region are capable of regulating sequence-specific annealing thereby enhancing primer-template hybridization for sequence-specific amplification of nucleotides.... Agent:

20110097765 - Enhanced fermentation process using molasses: Described herein are compositions and methods for enhanced fermentation of molasses using transglucosidase.... Agent:

20110097766 - 1,2 - addition of carbonyl compounds using the enzyme yere: R2 is an aromatic or heteroaromatic radical which may possibly be monosubstituted or disubstituted with halogen and/or a C1-C6 alkyl or is a substituent having the formula -A-B-C-D where A and C are each a C1-C6 alkyl, carbonyl or a covalent bond, B is a heteroatom such as oxygen and... Agent: Albert-ludgwigs-universit&#xc4 T Freiburg

20110097767 - Microorganisms for the production of aniline: A non-naturally occurring microbial organism having an aniline pathway includes at least one exogenous nucleic acid encoding an aniline pathway enzyme expressed in a sufficient amount to produce aniline. The aniline pathway includes (1) an aminodeoxychorismate synthase, an aminodeoxychorismate lyase, and a 4-aminobenzoate carboxylyase or (2) an anthranilate synthase and... Agent:

20110097768 - Novel burkholderia multivorans lg 31-3, amidase produced from the same, and method for resolution of racemic mixture using the same: The present invention relates to a novel Burkholderia multivorans, an amidase produced from the same, and a method for optical resolution of a racemic mixture using the same, and more particularly to a strain Burkholderia multivorans LG 31-3, an amidase having stereoselective substrate specificity, and a method for optical resolution... Agent: Lg Chem, Ltd.

20110097771 - Isolated polynucleotides and polypeptides and methods of using same for increasing plant utility: Provided are isolated polypeptides comprising the amino acid sequence at least 80% homologous to SEQ ID NO:68, 51-66, 69-100, 379-656, 707-715, 720-723, 742-754, 764-771 or 772 with the proviso that the amino acid sequence is not as set forth by SEQ ID NO: 765 or 771, isolated polynucleotides comprising the... Agent:

20110097769 - Modified microorganism uses therefor: The invention provides a genetically modified microorganism that acquires the ability to consume a renewable feedstock (such as cellulose) and produce products. This organism can be used to ferment cellulose, one of the most abundant renewable resources available, and produce products.... Agent:

20110097770 - Novel method to generate bioactive compounds in algae: The present invention discloses a novel microalgae-based method, called Microalgae Genomics Technology™ (MaGT), which can be used to generate novel compounds or increase the existing compounds in algae, and revealed some example of its potential applications. Specifically, this method utilizes microalgae genomics technology to manipulate the metabolic pathways in the... Agent:

20110097772 - Method for producing xylitol from lignocellulosic hydrolysates without detoxification: A method for producing xylitol by fermentation of lignocellulosic hydrolysates without detoxification is provided. By using the originally isolated yeast Candida sp., xylose can be effectively converted into xylitol. The invention also provides the Candida strain having high furfural tolerance, and is capable to produce xylitol from various types of... Agent: Institute Of Nuclear Energy Research Atomic Energy Council, Executive Yuan

20110097773 - Method for producing butanol using extractive fermentation: A method for producing butanol through microbial fermentation, in which the butanol product is removed by extraction into a water-immiscible extractant composition comprising a first solvent and a second solvent, is provided. The first solvent is selected from the group consisting of C12 to C22 fatty alcohols, C12 to C22... Agent: Butamax(tm) Advanced Biofuels LLC

20110097775 - Production of butanol: The present invention relates to methods for making recombinant thermophilic bacteria of the family Bacillaceae. In particular, recombinant thermophilic Bacillaceae are provided which have been engineered to produce butanol and/or butyrate. Preferably, heterologous nucleic acid molecules encoding one or more butanol or butyrate biosynthetic pathway enzymes are introduced into a... Agent: Green Biologics Limited

20110097774 - Visible light-enhanced enzymatic promotion of hydrocarbon reactions: A photocatalytic method for the hydroxylation of alkanes involving the use of a Cytochrome P450 class of enzyme as a catalyst which is activated by exposure to a pulsed blue light emitted from a light emitting diode (LED) at 450 nm±25 nm.... Agent:

20110097778 - Chimeric alpha-amylase variants: Chimeric alpha amylases having the characteristics of high thermostability and good performance in starch degradation, especially high-temperature liquefaction processes, are provided. The alpha-amylases are chimeras of AmyL and AmyS enzymes, and are useful in starch degradation processes. Methods of making the chimeric enzymes, and methods of using the chimeric alpha-amylases... Agent:

20110097776 - Novel ethanol-producing yeast: A novel isolated Pichia stipitis strain is provided. The strain is capable of fermenting at least a pentose sugar in the presence of one or more inhibitory substances to produce ethanol. A method of utilizing the strain to produce ethanol is also provided.... Agent:

20110097777 - Processes for extraction of sugar from sugar-bearing plant material: The invention provides processes for the extraction of sugar from sugar-bearing plant material such as sugar cane. Accordingly, in one aspect of the invention, a process for extracting sugar from sugar-bearing plant material comprises contacting the sugar-bearing plant material with an extractant solution comprising water and a surfactant; and separating... Agent: Dow Brasil Sudeste Industrial Ltda.

20110097779 - Processes for producing fermentation products: The present invention relates to processes for producing a fermentation product from gelatinized and/or un-gelatinized starch-containing material using a metallo protease, and processes for producing a fermentation product from gelatinized starch-containing material using a metallo protease and a pullulanase.... Agent:

20110097780 - Method of xylose fermentation having enhanced conversion rate in fiber solution: A method is provided for improving the efficiency of xylose fermentation in lignocellulosic hydrolysate. The disclosed embodiment raises the efficiency of xylose conversion by adding a specific lignocellulosic material during fermentation. In particular, a 10% enhancement in the efficiency of xylose conversion for ethanol production was given, and the ethanol... Agent: Atomic Energy Council-institute Of Nuclear Energy Research

20110097781 - Immobilized biological material with improved functionality and method for producing the same: The present invention provides methods and systems for performing biological reactions with biologically active entities immobilized on a solid support. Particularly, the invention provides a biologically active entity immobilized a support through a spacer linked to a first linker. The spacer gives the biologically active entity a certain level of... Agent: Co2 Solutions Inc.

20110097782 - Method, agent, and kit for isolating nucleic acids: A method for isolating nucleic acids is provided. The method includes providing a biological sample containing at least one nucleic acid, and mixing the biological sample with an isolating agent under a suitable condition to isolate the nucleic acids from the biological sample in single step, wherein the isolating agent... Agent: Industrial Technology Research Institute

20110097783 - Proteases from gram-positive organisms: The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for Bacillus MP. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding MP. The... Agent:

20110097784 - Thermostable organic solvent tolerant protease from gram-positive bacteria: The present invention relates to a thermostable protease useful as an enzyme for industrial use, a gene encoding the same and a method of producing the enzyme by genetic engineering technique. More particularly, the present invention discloses a thermostable organic solvent tolerant protease and its code gene and application. The... Agent: Universiti Putra Malaysia

20110097785 - Method of replicating viruses in suspension cultures of dog kidney cells: Animal cells are described which can be infected by viruses and which are adapted to growth in suspension in medium free of animal-derived components, such as serum-free medium. Processes for the replication of viruses in cell culture using these cells are furthermore described, as well as vaccines which contain the... Agent:

20110097786 - Methods of saccharification of polysaccharides in plants: Saccharification of polysaccharides of plants is provided, where release of fermentable sugars from cellulose is obtained by adding plant tissue composition. Production of glucose is obtained without the need to add additional β-glucosidase. Adding plant tissue composition to a process using a cellulose degrading composition to degrade cellulose results in... Agent: Applied Biotechnology Institute

20110097787 - Constant-temperature equipment: Constant-temperature equipment wherein maintenance is facilitated with the least failure, and highly reliable culturing and testing can be carried out. Mechanical and electrical structures are eliminated from the inside of a temperature-controlled chamber (15) by using a non-contact magnetic arrangement as a drive transmission for a sample table (5) and... Agent:

20110097788 - Nano and micro-technology virus detection method and device: The invention relates to methods and devices for detecting the presence of a particle of interest (hereinafter an analyte particle) in a fluid. A detection device exemplary of the present invention filters a sample of the fluid to remove particles larger than the analyte particles. A reagent solution, containing reagent... Agent: Accella Scientific Inc.

20110097789 - Tube ports and related container systems: A tube port includes a tubular first stem having an interior surface and an exterior surface extending between a first end and a longitudinally spaced apart second end. The interior surface bounds a passage that longitudinally extends through the first stem. The tube port also includes a flange encircling and... Agent: Hyclone Laboratories, Inc.

20110097790 - Lockable cell growth chamber with aintilocking feature: A lockable cell growth chamber is disclosed wherein the lid and base of the dish are provided with at least two pairs of locking and anti-locking members, the locking and antilocking functions being activated by application of rotational torque.... Agent: Biomerieux, Inc

20110097791 - Novel process, construct and conjugate for producing multiple nucleic acid copies: This invention provides inter alia an in vitro process for producing multiple specific nucleic acid copies in which the copies are produced under isostatic conditions, e.g., temperature, buffer and ionic strength, and independently of any requirement for introducing an intermediate structure for producing the copies. In other aspects, the invention... Agent:

20110097793 - Cell separation device, cell separation system and cell separation method: A cell separation device which can perform a continuous processing without bonding fluorescent molecules or magnetic particles to the surface of the cell membrane, a cell separation system, and a cell separation method, wherein when a sample cell suspension containing the desired target cells is supplied continuously from a sample... Agent: The University Of Tokyo

20110097792 - Interleukin-12p40 variants with improved stability: Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.... Agent: Merck Patent Gmbh

20110097794 - Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof: The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation... Agent: Intrexon Corporation

20110097795 - Desiccated biologics and methods of preparing the same: The present invention provides compositions comprising desiccated biologics comprising a cell, protein, virus, nucleic acid, carbohydrate, or lipid, or any combination thereof, along with at least one membrane penetrable sugar, and at least one membrane impenetrable sugar, wherein the moisture content is from 5% to 95%, and to methods of... Agent: Hememics Biotechnologies, Inc.

20110097796 - Method for freezing and storing cells: This invention relates to a method for freezing and storing cells in a container, and relates to frozen cells in freezing medium in a container.... Agent: Ccs Cell Culture Service

20110097798 - Mammalian cell expression vectors and utilization: An improved mammalian expression vector system which allows: (1) highly expressing exogenous proteins in host mammalian cells; (2) rapidly and efficiently screening recombinant stable cell lines expressing the gene of interest; (3) maintain sustainable expression and prevent gene silencing; and (4) effectively secreting proteins into media in some of cases.... Agent: Atgcell Inc.

20110097797 - Modular functional peptides for the intracellular delivery of nanoparticles: Described are peptides for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain; (b) a proline-rich spacer domain; (c) an uptake domain; and (d) a vesicle escape domain comprising a non-hydrolyzable lipid moiety, wherein the spacer domain is between the nanoparticle association domain and... Agent: The Government Of United States Of America, As Represented By The Secretary Of The Navy

20110097799 - Cardiomyocyte production: Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem... Agent:

20110097800 - Method and apparatus for retaining and recirculating cells: t

20110097802 - Organic-inorganic composite dispersion, cell culture substrate manufactured using the same, and methods for preparing the same: Disclosed are: an organic-inorganic complex dispersion improved in film formability and adhesion to a base material. The organic-inorganic complex dispersion comprises an aqueous medium and particles of a complex dispersed in the aqueous medium, wherein the complex has a three-dimensional network structure formed by a polymer of a monomer comprising... Agent: Dic Corporation

20110097801 - Tissue scaffolding composites: A method for preparing a biocompatible polymeric composite includes modifying a first biocompatible polymer with a primer group to form a modified biocompatible polymer; blending the modified biocompatible polymer with a second biocompatible polymer and an inorganic material; allowing the primer group of the modified biocompatible polymer to react with... Agent:

20110097803 - Cldn5 mini-promoters: Isolated polynucleotides comprising a CLDN5 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of... Agent:

20110097804 - Targeted gene modification by parvoviral vectors: This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing.... Agent: University Of Washington

  
04/21/2011 > patent applications in patent subcategories. category listing, related patent applications

20110091862 - Generation of an hla-negative osteogenic precursor cell line: The present disclosure provides methods for producing human osteogenic cell lines in which HLA Class I expression is absent or reduced. The resulting osteogenic cells can then be used, for example, to form mineralized three-dimensional bone constructs which can be used, for example, in bone grafting procedures. The lack of... Agent: Osteosphere, LLC

20110091863 - Blood substitute solution: The invention relates generally to blood substitute solutions and methods for using blood substitute solutions. The solutions may be used in a variety of applications and are particularly suited for use in applications where at least a portion of a host's blood is replaced with a substitute solution.... Agent:

20110091864 - Device and use thereof: Disclosed herein is a device comprising at least one supporting solid surface comprising at least one membraneophilic region; a covering layer that is at least partially immobilized to the membraneophilic region, said covering layer consisting of (i) a surfactant membrane, (ii) a lipid mimicking polymer, (iii) a surfactant or emulsion... Agent: Nanoxis Ab

20110091866 - Detection of polyomavirus: Methods and kits are provided for testing for the presence or absence of a polyomavirus, such as BKV, in a sample. The methods and kits are useful for quantifying BKV and differentiating BKV from JCV.... Agent:

20110091865 - Measuring multiple analytes over a broad range of concentrations using optical diffraction: The invention relates to method, devices, and kits for measuring multiple analytes in a sample having a broad range of concentrations using optical diffraction. Devices, methods, and kits useful for monitoring and diagnosing diabetes, cardiovascular disease, thyroid disease, hormone-related conditions, and sepsis are also described.... Agent:

20110091869 - Method for culture of stem cell: The present invention enables efficient suspension culture of stem cells in a serum-free medium by comprising a step for quickly forming a homogenous aggregate of stem cells, and provides a method of selectively inducing the differentiation of nerves from a stem cell, a method of forming a cerebral cortical nerve... Agent: Riken

20110091867 - Method to identify and predict disease progression of human papilloma virus-infected lesions: The present invention provides a method for distinguishing benign human papilloma virus (HPV)-infected tissue from HPV-related lesions that have undergone malignant transformation. In one embodiment, the invention comprises a simple histochemical staining method and details a novel process for examining HPV-infected cells by determining susceptibility to enzymatic DNA digestion. Residual... Agent: The Feinstein Institute For Medical Research

20110091868 - Novel antigen constructs useful in the detection and differentiation of antibodies to hiv: Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences... Agent: Abbott Laboratories

20110091871 - Biomarkers for predicting response of esophageal cancer patient to chemoradiotherapy: The present invention relates to novel genetic markers associated with response of a patient with esophageal cancer (ECa) to chemoradiation therapy, and particularly to methods and kits for predicting an ECa patient's response to chemoradiation therapy by genotyping of the markers.... Agent: National Taiwan University

20110091893 - Biosensors for detecting macromolecules and other analytes: The invention generally provides molecular biosensors. In particular, the invention provides molecular biosensors having one or more aptamers. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules.... Agent: Saint Louis University

20110091889 - Centrosome-assay: The present invention provides a centrosome assay for the identification of preferably, Eg5 inhibitors.... Agent: 4sc Ag

20110091899 - Combination of risk alleles associated with autism: The present invention relates to a method of detecting the presence of or predisposition to autism, or to an autism spectrum disorder, the method comprising detecting the presence of an alteration in the gene loci PITX1, ATP2B2, SLC25A12 and EN2 in a sample from said subject. More particularly, the presence... Agent: Integragen

20110091885 - Composition comprising an oligonucleotide mixture for the detection of contaminations in cell cultures: The present invention relates to a method for determining contaminations in a cell culture sample comprising the steps of: a) contacting a sample of a cell culture suspected to comprise contaminations with a composition comprising oligonucleotides under conditions which allow for amplification of polynucleotides, wherein said oligonucleotides comprise oligonucleotides of... Agent: Dkfz Deutsches Krebsforschungszentrum Stiftung Des &#xf6 Ffentlichen Rechts

20110091897 - Compositions comprising nanomaterials and method for using such compositions for histochemical processes: Histochemical process compositions comprising at least one nanoparticle in an amount effective to reduce or substantially eliminate the average number of spots per slide that result from a sample staining protocol are disclosed. Various nanoparticles, or combinations thereof, including metals, metal alloys, metal oxides, ceramics, functionalized metals or metalloids, and... Agent:

20110091878 - Dairy cattle breeding for improved milk production traits in cattle: Nucleic acid molecules comprising a SNP site at position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), which SNP indicates a desirable productive life in a dairy cattle. Also disclosed are an array or a kit comprising the same, a method for detecting the SNPs,... Agent: Wisconsin Alumni Research Foundation

20110091872 - Detecting triazole resistance in aspergillus: Methods are provided for detecting triazole -resistant fungi in a sample. The methods comprise evaluating the sample for the presence of a gene encoding a mutant AzRF1 transcription factor, or the level of the transcription factor, to determine whether a fungus is triazole-resistant. Primers, probes and kits also are provided.... Agent: Myconostica Ltd

20110091898 - Detection probe: A nucleotide probe permitting the detection of nucleic acids and constituted of a labeled nucleotide strand having three fragments: a first fragment having a first closing sequence, a second fragment, all or part of which has a recognition sequence for the molecular recognition of the target nucleic acid and a... Agent: Biomerieux

20110091882 - Determination of methylation status of polynucleotides: The present invention provides compositions and methods for detecting the methylation status of a nucleic acid. In particular, the present invention provides a mass spectrometry-based method of determining DNA methylation status without sequencing.... Agent: Ibis Biosciences, Inc.

20110091895 - Immunoassays to detect diseases or disease susceptibility traits: Disclosed are immunoassay methods for the diagnosis/prognosis of diseases and disease susceptibility traits associated with gene mutations that cause protein truncation or allelic loss. The levels of one or more targeted wild-type proteins expressed by a subject gene or genes are immunologically quantitated in biological samples. Results indicating that a... Agent:

20110091873 - Integrated sample preparation and amplification for nucleic acid detection from biological samples: Beads are used to perform both a sample preparation and amplification process within a single processing chamber. A fluid sample including a plurality of cells is introduced into a processing chamber already including a plurality of beads. The plurality of cells are lysed within the processing chamber, and nucleic acid... Agent: Microfluidic Systems, Inc.

20110091884 - Method for analysis of dna methylation: Provided is a method for analysis of DNA methylation. A first method comprises: (1) a step in which analyte DNA is digested with methylation-insensitive restriction enzyme(s) that produce overhanging end(s) and that contain methylated cytosine or methylatable cytosine in recognition sequence(s) thereof; (2) a step in which adaptor(s) capable of... Agent:

20110091896 - Method for analysis/identification of antibody gene at one-cell level: Disclosed are: a method for identifying/analyzing a gene for an antibody in one cell derived from a human; a technique for producing an antibody derived from an identified one B cell; and others. A gene for an antibody specific to a melanoma antigen is analyzed/identified at a one-cell level by... Agent: Shizuoka Prefecture

20110091887 - Method for detection of methylcytosine using photoresponsive probe: The present invention provides a method for detecting methylcytosine in DNA rapidly, conveniently, and with high sensitivity. The present invention relates to a method for detecting methylcytosine by using a methylcytosine photocoupling agent (a photoresponsive probe) consisting of nucleic acids having a group represented by the Formula (I), (II), (III)... Agent: Japan Science And Technology Agency

20110091900 - Method for determining dna copy number by competitive pcr: The present invention relates to a method for determining the number of copies of DNA at a specific locus. The method comprises the step of co-amplifying a DNA sample of an exploratory species comprising the test locus with a competitor sample comprising an orthologous DNA sequence derived from a closely... Agent:

20110091886 - Method of distinguishing inflammatory pathogen causing acute respiratory infection: Disclosed is a method of distinguishing an inflammatory pathogen causing acute respiratory infection wherein the pathogen to be distinguished is a pathogen residing in the respiratory tract, which comprises: (a) a step for counting gene copies originating in subject cells in DNA prepared from a specimen containing secretion from the... Agent: Saitama Medical University

20110091883 - Methods for analyzing minute cellular nucleic acids: The invention generally relates to methods for analyzing cellular nucleic acid. Methods of the invention involve capturing RNA from a lysed cell onto a substrate, producing a cDNA/RNA duplex, removing the RNA from the cDNA/RNA duplex, priming the cDNA to produce a primer/cDNA duplex, exposing the primer/cDNA duplex to at... Agent: Helicos Biosciences Corporation

20110091892 - Methods for the diagnosis and treatment of lung cancer: The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition.... Agent: Johns Hopkins University School Of Medicine

20110091879 - Mobile device for isolation of nucleic acids: The invention relates to a mobile device system, comprising a hand-held device and a test kit for the mobile isolation of nucleic acids. The hand-held device comprises at least one sample block for inserting sample containers, a sample block holder with boreholes or recesses for accommodating the sample blocks, a... Agent: Aj Innuscreen Gmbh

20110091870 - Multisite biosensor and associated method: A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of... Agent: Office Of Technology Licensing

20110091881 - Mycobacterial genes down-regulated during latency: A method is provided for identifying mycobacterial genes the expression of which is down-regulated during a stationary phase culture of mycobacteria under nutrient-starving conditions when compared with an exponential phase culture of mycobacteria under culture conditions that are not nutrient-starving and that support exponential growth of said mycobacteria. The described... Agent:

20110091894 - Oligonucleotides for amplifying chlamydophila pneumoniae nucleic acid: Oligonucleotides for use in determining the presence of Chlamydophila pneumoniae in a test sample. The oligonucleotides are incorporated into detection probes, capture probes, and amplification oligonucleotides, and can be used in various combinations thereof.... Agent: Gen-probe Incorporated

20110091891 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Canon Kabushiki Kaisha

20110091880 - Susceptibility variants for lung cancer: The present invention discloses certain genetic variants as susceptibility variants for lung cancer. The invention relates to methods of risk assessment using such variants. The invention further relates to kits for use in risk assessment of lung cancer.... Agent: Decode Genetics Ehf.

20110091877 - Systems and methods for minimization or elimination of diffusion effects in a microfluidic system: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow.... Agent: Canon U.s. Life Sciences, Inc.

20110091875 - Three-component gene expression reporting system for mammalian cells and applications of the same: Disclosed herein is a three-component gene expression reporting system for mammalian cells, the system including a first expression cassette, a second expression cassette, and a methylated polynucleotide. The three-component gene expression reporting system can be used to establish recombinant mammalian cells for use in the screening of a demethylating agent.... Agent: National Chung Cheng University

20110091890 - Trichoplusia ni cell line and methods of use: An isolated cell from the cell line identified as TnT4. This cell may be infected with a baculovirus expression vector which may carry a heterologous nucleotide that encodes a polypeptide, such as a membrane protein, e.g., human neurotensin receptor 1. Also included is a method for using this cell line... Agent:

20110091874 - Ultrasensitive detection of target using target-ready particles: The invention relates to methods and reagents for detecting minute amounts of targets having affinity for nucleic acid. The present invention more particularly relates to target detection using aggregates of cationic polymer chains and nucleic acid capture probes linked to particles, such as controllable mobility particles.... Agent: National Research Council Of Canada

20110091888 - Use of cathepsin c: Present invention concerns the use of Cathepsin C. Other aspects of the invention concern methods for screening pharmaceuticals, for diagnosing pain susceptibility and for the treatment of pain.... Agent: Sanofi-aventis

20110091876 - Zcytor19 polynucleotides, polypeptides, antibodies and methods of use: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor... Agent: Zymogenetics, LLC

20110091902 - Method of assaying physiologically active substance of biological origin, kit for assaying physiologically active substance of biological origin and apparatus for assaying physiologically active substance of biological origin: Provided is a technique whereby a physiologically active substance of biological origin such as an endotoxin or β-D-glucan can be more conveniently and accurately detected and the concentration thereof can be determined even in the case of using a sample which contains a substance affecting LAL activity. For example, a... Agent: Kowa Company, Ltd.

20110091901 - Vectors and methods for screening cells for high expression of protein of interest (poi): This invention refers to industrial production of proteins. More particularly, the invention refers to a fusion protein as a novel chimeric selection marker comprising a peptide conferring resistance to an antibiotic, or a fragment, allelic variant, splice variant or mutein thereof, and at least one sequence comprising SEQ ID NO:... Agent: Merck Serono Sa

20110091904 - Method for determination of affinity and kinetic constants: The invention is related to a method for quantification of a first dissociation equilibrium constant Kd1 for a complex AB between interactants A and B relative to a second dissociation equilibrium constant Kd2 for a complex CD between interactants C and D.... Agent: Gyros Patent Ab

20110091903 - Method of analyzing a sample for a bacterium using diacetylene-containing polymer sensor: The invention relates to methods of analyzing a sample for a bacterium of interest. In particular, the methods involve an initial capture process that includes the use of one or more antibodies having antigenic specificities for one or more distinct analytes characteristic of the specific bacterium. After initial capture of... Agent:

20110091908 - Early prostate cancer antigen-2: a novel serum specific marker for prostate cancer detection: Early Prostate Cancer Antigen-2 (EPCA-2) is a prostate cancer biomarker, newly identified via proteomics-based examination of alterations in nuclear structure. EPCA-2 shows a higher overall specificity than PSA. Thus, an immunoassay based on antibodies against an epitope of EPCA-2 more accurately differentiates between confined and non-confined disease than PSA or... Agent: University Of Pittsburgh - Of The Commonwealth System Of Higher Education

20110091907 - Method for detection of liver cancer cell using anti-glypican-3 antibody: The present invention relates to an in-vitro immunoassay method for detecting the presence of liver cancer cells in a subject. In the method of the present invention, antigen retrieval treatment based on heat-induced epitope retrieval method and antigen retrieval treatment based on protease-induced epitope retrieval method can be combined in... Agent: Chugai Seiyaku Kabushiki Kaisha

20110091909 - Stabilizing agents and capture ligands for use in assays measuring analyte concentrations: The present invention is related to compositions useful for the measurement of free or unbound analyte concentrations in a fluid. The present invention includes the use of capture ligands and stabilizing agents to improve the accuracy of analyte concentration assays. Methods and tools for using the present invention are also... Agent: Beckman Coulter, Inc.

20110091905 - Biochip and method of detecting reaction from the same: Provided are a biochip and a method of detecting a reaction from the biochip. This method includes preparing a first mixture solution of polyvinylpyrrolidone (PVP) and a sample including target molecules, measuring absorbance or transmittance of the first mixture solution, preparing a second mixture solution including the PVP, the sample,... Agent: Electronics And Telecommunications Research Institute

20110091906 - Immuno gold lateral flow assay: A chromatographic specific binding assay strip device, comprising: a non-permeable platform strip; a permeable membrane testing strip positioned on top of said non-permeable platform strip, with the testing strip comprising at least one capture reagent site containing a capture reagent for at least one specific analyte, a sample receiving pad... Agent:

20110091911 - Antibodies, systems and methods for determining relative hemolytic index: Disclosed herein are antibodies, systems and methods for assessing the risk of hemolysis following a blood transfusion with crossmatch incompatible blood. The disclosure provides a method for determining the relative hemolytic index and therefore the risk of post-transfusion hemolysis for said patient.... Agent: New York Blood Center, Inc.

20110091913 - Drug safety test using pentraxin-3 (ptx-3): The invention relates to an in vitro method for assessing the immunogenicity of a compound of interest comprising the steps of: a) providing a whole blood sample, wherein said blood was exposed to said compound of interest, b) measuring the level of pentraxin-3 in said sample, and c) comparing the... Agent:

20110091912 - High molecular weight ngal as a biomarker for chronic kidney disease: A high molecular weight form of Ngal is provided which can be used to diagnose chronic kidney disease. High molecular weight Ngal is about 75 kDa to about 350 kDa, and comprises non-Ngal proteins, such as polymeric immunoglobulin receptor, alpha-2-macroglobulin and immunoglobulin heavy chain. Methods are disclosed for assessing high... Agent:

20110091910 - Novel assay: A novel method for detection of Aβ peptides, in particular in plasma, and to the use of Aβ peptides for diagnosis of Alzheimer's disease.... Agent: Probiodrug Ag

20110091915 - Iga nephropathy testing method and test kit: There is provided a renal disease testing method comprising a complex detection step of detecting a complex of human uromodulin and human IgA in a sample derived from urine collected from a subject. It is preferred that the renal disease testing method of the invention further comprises a determination step... Agent:

20110091914 - Immunological test element with improved control zone: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical... Agent: Roche Diagnostics Operations, Inc.

20110091916 - Luciferin-luciferase based microdevice for biosensing: A method and apparatus for determining the concentration of one or more microbes in a sample is provided. This method involves filtering a sample through a filter inside a sample tube to retain the one or more microbes on the filter. The resulting filtrate, which contains or produces adenosine triphosphate,... Agent: Honeywell International Inc.

20110091917 - Method of measuring lipid in specific lipoprotein: A method of measuring a lipid in a specific lipoprotein characterized by using a polycyclic polyoxyalkylene derivative at least in the step of determining the specificity of the measurement of the target lipid.... Agent: Daiichi Pure Chemicals Co., Ltd.

20110091918 - Heterogeneous coagulation test: Within the field of coagulation diagnostics, in heterogeneous methods for determining the activity of blood coagulation factors and also in heterogeneous methods for determining anticoagulants which inhibit the activity of blood coagulation factors, a sample is contacted with a cleavable substrate, and the amount of uncleaved substrate is subsequently determined.... Agent:

20110091919 - Ph-insensitive glucose indicator protein: The present invention encompasses a glucose indicator protein, a biosensor comprising one or more glucose indicator proteins, and methods of use thereof.... Agent: Board Of Trustees Of The University Of Arkansas

20110091920 - Method of diagnosing a clinical condition by detection of a papp-a/prombp complex: The present invention provides a method of diagnosing Down's syndrome, acute coronary syndrome or pre-eclampsia, or a predisposition to any of them, by a method comprising measuring the level of the human PAPP-A/proMBP complex in a body fluid sample.... Agent: Como Biotech Aps

20110091921 - Novel 12 alpha-hydroxysteroid dehydrogenases, production and use thereof: The invention relates to 12 α-hydroxysteroid dehydrogenases, nucleic acid sequences coding for the same, expression cassettes and vectors, recombinant microorganisms containing the corresponding coding nucleic acid sequences, a method for producing said 12 α-hydroxysteroid dehydrogenases, a method for enzymatic oxidation of 12 α-hydroxysteroids using said enzyme, a method for enzymatic... Agent: Pharmazell Gmbh

20110091928 - Agent for recruitment of bone-marrow-derived pluripotent stem cell into peripheral circulation: e

20110091922 - Bio-matrix stretcher: Embodiments provide techniques for measuring and characterizing the dynamics of cell traction forces. Tunable elastic gel substrates can be disposed in multi-well plates. The gels can be of a uniform predetermined thickness. A multi-well plate can be loaded with gels of different shear moduli. An array of punch indenters can... Agent:

20110091923 - Compact optical reader system: A method and optical reader system for label-independent detection as defined herein. The reader system includes: a launch beam; a first lens; a receptacle for receiving at least one optical biosensor article, the article having a mask on one face, and the mask having at least one aperture there through... Agent:

20110091929 - Means and methods for assessing liver enzyme induction: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological... Agent: Basf Se

20110091924 - Method of evaluating cancer type: According to the method of evaluating cancer type of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and the cancer type in the subject is evaluated based on the concentration value of at least... Agent: Ajinomoto Co., Inc.

20110091927 - Motor neurons developed from stem cells: The present invention provides a method for directing differentiation of neural progenitors with a caudal and ventral specification into motor neurons comprising culturing neural progenitors in a culturing medium comprising a basic medium supplemented by at least one inhibitor of the Notch signaling pathway whereby said neural progenitors differentiate into... Agent: Hadasit Medical Research Services & Development Limited

20110091926 - Perfusable bioreactor for the production of human or animal tissues: A perfusable bioreactor is used for the production of human tissues, animal tissues or tissue equivalents. Their production is based on a structure cultivated in the interior, the interior being enclosed by an envelope and containing at least one inlet and one outlet for a liquid nutrient medium. Accordingly, the... Agent: Novatissue Gmbh

20110091925 - Processing of nanoparticles: Ligand-capped nanoparticles are dispersed in an organic solvent. There is then phase transfer of the nanoparticles introducing into the organic solvent an aqueous solution of polymer surfactant dissolved in water. The organic solvent and the aqueous solution are then mixed until the polymer forms micelles which encapsulate the nanoparticles in... Agent:

20110091930 - Well-based flow system for cell culture: A well-based flow system for cell culture is described which provides for flow of culture containing compounds for drug screening to be exposed to cells seeded on a membrane. The flow of medium may be planar or radial and means are provided for the removal of waste media through fluid... Agent: The General Hospital Corporation

20110091932 - Automated extraction and purification of samples using optical tweezers: An apparatus and method for purifying a forensic sample using an automated extraction and purification system includes optical tweezers; an input channel through which the sample is introduced; a chamber which receives the sample from the input channel; a collection channel through which selected particles of the sample are removed;... Agent: Arryx, Inc.

20110091931 - Methods and kits for determining oxygen free radical (ofr) levels in animal and human tissues as a prognostic marker for cancer and other pathophysiologies: Described herein are methods and techniques for the determination of reactive oxygen species in resected animal and human tissues. Also described herein are methods for determining the efficacy of anti-oxidant, oxidative stress modulatory, or anti-inflammatory drug chemoprevention or chemotherapy for the prevention and/or therapy of chronically inflamed and/or progressive cancers... Agent: Colby Pharmaceutical Company

20110091933 - Method of treating microorganism: A method of treating microorganisms which can solve conventional problems in a treatment of counting the number of microorganisms, a proliferation treatment of microorganisms and a purification treatment of microorganisms is provided. A method of treating microorganisms in which any one of the intended treatments of a treatment of counting... Agent: Fujifilm Corporation

20110091934 - Laccase variants: The present invention relates to variants of a parent laccase. The present invention also relates to polynucleotides encoding the variant laccases and to nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and methods of using the variant enzymes.... Agent: Novozymes A/s

20110091935 - Production of recombinant proteins in synthetic medium: The invention relates to a method for the production of recombinant proteins by eucaryotic cells in synthetic culture media, wherein said eucaryotic cells are transfected with a composition comprising a synthetic transfection reagent based on a polyhydroxylated polyalkyleneimine.... Agent: Polyplus Transfection Sas

20110091936 - Production of proteins in glutamine-free cell culture media: The present invention relates generally to glutamine-free cell culture media supplemented with arginine. The invention further concerns the production of recombinant proteins, such as antibodies, in arginine-supplemented glutamine-free mammalian cell culture.... Agent:

20110091937 - Method of producing clostridium botulinum toxin using media containing plant-derived components and flexible closed container: Provided are a method of producing Clostridium botulinum toxin by using a media containing plant-derived components, and a method of producing Clostridium botulinum toxin by using a flexible closed container.... Agent: Medy-tox Inc.

20110091938 - Starch hydrolysis: Disclosed is a method for hydrolyzing starch. The starch is subjected to hydrolysis in the presence of a neutral calcium salt, the hydrolysis being conducted at a pH ranging from about 5.0 to about 5.5. The calcium salt may be a non-toxic and label-friendly salt such as calcium sulfate, calcium... Agent: Grain Processing Corporation

20110091939 - Methods and compositions for removing specific target nucleic acids: The present invention provides methods, compositions and kits for removing specific target nucleic acid(s) from a nucleic acid sample. In particular, present invention provides a blocker oligonucleotide to prevent the target nucleic acid from binding to captor oligonucleotides, thus removing the target nucleic acid from a captor-binding nucleic acid pool.... Agent:

20110091940 - Highly disordered cellulose: Disclosed are methods and systems for treating cellulose to make it more accessible for enzymatic or chemical modification. The invention includes treating cellulose with an alkali in an alcohol/water co-solvent system. The treatment decrystallizes or deaggregates the cellulosic material. The methods and systems increase the efficiency of enzymatic or chemical... Agent: Cellulose Sciences International, Inc.

20110091941 - Process for producing fermentation products: The invention relates to processes for hydrolyzing lignocellulose-containing material. The invention also relates to processes of producing fermentation products including a hydrolysis process of the invention.... Agent: Novozymes A/s

20110091942 - Process for production of cis-4-hydroxy-l-proline: Development of a method of economically and efficiently producing cis-4-hydroxy-L-proline. The present invention provides L-proline cis-4-hydroxylase. This enzyme may be derived from Lotus corniculatus rhizobia, Mesorhizobium loti or Medicago sativa rhizobia, Sinorhizobium meliloti. The present invention provides a method of producing cis-4-hydroxy-L-proline from L-proline by using this enzyme. The present... Agent: Kyowa Hakko Bio Co., Ltd.

20110091943 - Semi-continuous and continuous enzymatic hydrolysis process: The present invention relates to an semi-continuous or continuous process for the regioselective enzymatic hydrolysis of alcohol groups protected e.g. as esters or amino-acid esters or phosphate groups The process of the present invention is useful for instance for the selective enzymatic hydrolysis of pyranosides or furanosides having more than... Agent: Andadys Pharmaceuticals, Inc.

20110091944 - Adipate (ester or thioester) synthesis: The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention... Agent: DsmIPAssets B.v.

20110091946 - Enzymatic process for obtaining a fatty ester: The aim of the present invention is to obtain fatty esters from fatty acids derived from vegetable oils and butters, through an enzymatic process, so that said esters can act as emollients, emulsifiers and co-emulsifiers with differentiated performance, having high spreadability and slidability compared to the prior-art products. More specifically,... Agent:

20110091947 - High-purity purification method for omega-3 highly unsaturated fatty acids: The present invention relates a high-purity purification method for omega-3 highly unsaturated fatty acids. More specifically, it relates to a high-purity purification method for omega-3 highly unsaturated fatty acids which is both environmentally friendly and easy to implement and comprises the steps of: a) preparing a fatty acid ethyl ester... Agent: Ak Biotech Co., Ltd.

20110091945 - Methods of increasing biomass productivity, lipid induction, and controlling metabolites in algae for production of biofuels using biochemical stimulants: The present disclosure provides methods of enhancing the biofuel potential of an algal culture, the ability of an algal culture to provide a biofuel such as a lipid or to be processed to a biofuel, the method comprising: contacting an algal culture with a composition selected to enhance the biofuel... Agent: University Of Georgia Research Foundation, Inc.

20110091948 - Microorganism capable of producing improved polyhydroxyalkanoate and method of producing polyhydroxyalkanoate by using the same: The present invention relates to a microorganism which is capable of producing a polyhydroxyalkanoate (PHA) and satisfies the requirements: (1) expression of a phbA gene is repressed or a catalytic activity of an enzyme encoded by the gene is repressed; (2) expression of a bktB gene is enhanced or a... Agent: Kaneka Corporation

20110091949 - Process for producing d-mannitol: High concentration of free cells of heterofermentative lactic acid bacteria (LAB) in a resting or slowly growing state are used to convert fructose into mannitol. Efficient volumetric mannitol productivities and mannitol yields from fructose are achieved in a process applying cell-recycle, continuous stirred tank reactor and/or circulation techniques with native... Agent: Zuchem, Inc.

20110091950 - Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having alpha-glucuronidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20110091951 - New class of chloroflexi-like thermophilic cellulose degrading bacteria: The present invention relates to a new class of Chloroflexi-like bacteria. The bacteria are thermophilic cellulose degrading bacteria. Compositions and methods for degrading cellulose using the Chloroflexi-like bacteria are also provided.... Agent: Institute Of Geological And Nuclear Sciences Limited

20110091952 - Method for enzymatic production of decarboxylated polyketides and fatty acids: Disclosed herein are methods of preparing alkenes from beta-hydroxy or beta-sulfate carboxylic acid or carboxylic acid derivatives using thioesterase and optionally a sulfotransferase.... Agent: The Regents Of The University Of Michigan

20110091953 - Method for converting organic material into a renewable fuel: Processes for converting organic material into renewable fuel products. A feedstock containing organic material is processed at an elevated pressure and temperature to lyse, decarboxylate, and carbonize cell structures. A portion of the processed slurry may be recirculated and mixed with cool, pressurized feedstock prior to reaching a mechanical mixing... Agent: Enertech Environmental, Inc.

20110091954 - Integration of anaerobic digestion in an algae-based biofuel system: Systems and methods for the treatment of lipid-extracted algae biomass and recycling nutrients are provided. The lipid-extracted algae biomass is hydrolyzed prior to anaerobic digestion, and the products generated by anaerobic digestion are further processed to yield by-products that are of use either for external use or as process inputs... Agent:

20110091955 - Methods and systems for treating industrial waste gases: Systems and methods for lowering levels of carbon dioxide and other atmospheric pollutants are provided. Economically viable systems and methods capable of removing vast quantities of carbon dioxide and other atmospheric pollutants from gaseous waste streams and sequestering them in storage stable forms are also discussed.... Agent:

20110091956 - Biomolecule-immobilized carrier and method for immobilizing biomolecule on carrier: Provided are a biomolecule-immobilized carrier obtained by immobilizing a biomolecule having a membrane-binding peptide containing a C terminal polypeptide of fucosyltransferase derived from Helicobacter pylori or a membrane-binding molecule having the membrane-binding peptide and various biomolecules and a method for immobilizing a biomolecule to a carrier, particularly a biomolecule-immobilized magnetic... Agent: National University Corporation Hokkaido Universit

20110091957 - Protein-polymer conjugates and synthesis thereof: A method of synthesizing a protein-polymer conjugate includes the steps: covalently attaching at least one controlled radical polymerization initiator to a protein to form a protein-initiator composition; and mixing the protein-initiator composition with at least one monomer which undergoes controlled radical polymerization in the presence of the protein-initiator composition under... Agent:

20110091958 - Multiply-substituted protease variants: Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino... Agent: Danisco US Inc.

20110091959 - Multiply-substituted protease variants: Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino... Agent: Danisco US Inc.

20110091960 - Compositions and methods for detection of antibody binding to cells: The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included.... Agent: The Trustees Of The University Of Pennsylvania

20110091961 - Tissue processor for treating tissue samples: A tissue processor for treating tissue samples comprises a process chamber (10) in which the tissue samples can be treated with at least one liquid. The process chamber (10) is formed as a vessel of a magnetic stirrer. In the process chamber, a stirring body (16) for stirring the liquid... Agent: Leica Biosystems Nussloch Gmbh

20110091962 - Automated stainer having stain level detection: An automated slide staining apparatus for staining slide samples is disclosed. The slide staining apparatus includes cuvette chambers that are flooded with solutions to cover a slide fitting within the cuvette chamber. Filling and emptying the chamber accomplishes a dipping function on the slide. The cuvette chamber includes a drainage... Agent:

20110091964 - Cell manipulation observation apparatus: An introducing position arrangement unit arranges a position of a cell into which a substance is introduced, of the cells in a culture dish mounted on a stage, specified by a specification unit to a predetermined cell manipulation position in a viewing field of an observation unit by stage driving.... Agent: Olympus Corporation

20110091965 - Cell manipulation observation apparatus: An introducing position arrangement unit arranges a position of a cell into which a substance is introduced, of the cells in a culture dish mounted on a stage, specified by a specification unit to a predetermined cell manipulation position in a viewing field of an observation unit by driving the... Agent: Olympus Corporation

20110091963 - High resolution flow cytometer: High resolution particle differentiation process and separation system that provides enhanced resolution of particles based upon selected particle characteristics. In particular, the system may include an enhanced resolution flow cytometer. In an embodiment, the invention can include at least one fluid source conduit (24) that introduces 0 fluid source stream... Agent: Xy, LLC

20110091966 - Antiviral peptide against hepatitis c virus: Disclosed herein is a small peptide, LaR2C, corresponding to the C terminus of RRM2 of the human La protein that binds to the IRES element of hepatitis C virus RNA and its derivatives. This invention demonstrates that human La protein interacts with the HCV IRES element both in vitro and... Agent:

20110091967 - Ssx-4 peptides presented by hla class ii molecules: The invention describes HLA class II binding peptides encoded by the SSX-4 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized... Agent: Ludwig Institute For Cancer Research Ltd.

20110091968 - Monoclonal antibody specific to both human interferon-alpha subtype alpha 8 and its mutant proteins: The present invention has the first object to provide a monoclonal antibody specific to interferon α subtype α8 (IFNα8) and its mutant proteins, the second object to provide a hybridoma capable of producing the monoclonal antibody, the third object to provide a method for detecting the IFNα8 and its mutant... Agent:

20110091969 - Mutations in the ns5b protein of the hcv: e

20110091970 - Methylation of estrogen receptor alpha and uses thereof: Methods for diagnosis, prognosis, and treatment of cancer based on the methylation status of the ER-α gene promoter are disclosed. Methylation of the ER-α gene promoter is indicative of cancer and unfavorable prognosis. The cancer can be treated with a demethylation agent.... Agent:

20110091971 - Differentiation of pluripotent stem cells: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. The present invention also provides methods to generate and purify agents capable... Agent:

20110091972 - Fabricating scaffolds and other cell-growth structures using microfluidics to culture biological samples: Methods and apparatuses for using microfluidics to generate bubbles and using the generated bubbles to construct scaffolds and cell-holding structures for culturing biological samples or analytes. In one implementation, a scaffold for growing cells is provided to include a matrix of interconnected cavities formed from mixing a gas and a... Agent: Academia Sinica

20110091973 - Modified and fusion enhanced erythrocytes, cells and uses thereof: Modified fusion enhanced erythrocytes (or other cell types and synthetic cells) including human viral receptor proteins, human viral coreceptor proteins and viral derived proteins capable of mediating entry of respective viruses into the modified erythrocytes, cells or pseudo-cells and the method of using the fusion enhanced modified erythrocytes, cells or... Agent:

20110091974 - Conductive substrate and method for introducing nucleic acid: A conductive substrate for introducing a nucleic acid into a cell, which comprises a carbon nanotube with a carboxyl group, and a nucleic acid, the carbon nanotube and the nucleic acid being loaded on an electrode substrate with a cationic surface.... Agent: Kyoto University

20110091975 - Down-regulation of gene expression using artificial micrornas: Isolated nucleic acid fragments comprising precursor miRNAs, and artificial miRNAs and their use in down-regulating gene expression are described.... Agent: E.i.du Pont De Nemours And Company

20110091976 - Regulatory region preferentially expressing to seed embryo and method of using same: A Zea mays regulatory region is shown, which provides improved seed preferred, and particularly embryo preferred expression in plants. Methods of use are also shown in preferentially expressing a heterologous protein to the embryo tissue of a plant. The sequence is particularly useful in expression of heterologous proteins to the... Agent: Applied Biotechnology Institute

20110091977 - Homologous recombination in an algal nuclear genome: Exemplary transformation methods are provided for introducing deoxyribonucleic acid (DNA) into the nucleus of an algal cell. A transformation construct may be prepared, with the transformation construct having a first sequence of DNA similar to a corresponding first sequence of nuclear DNA, a second sequence of DNA similar to a... Agent:

  
04/14/2011 > patent applications in patent subcategories. category listing, related patent applications

20110086336 - Reproductive cell maintenance system: Extracts obtained from the genus Hippophae or other plant sources or compositions produced by chemical or molecular biological techniques each having in common certain moieties in amounts effective when combined with reproductive cells to reduce the loss of function.... Agent: Membrane Protective Technologies, Inc.

20110086337 - Fluid transfer control for real-time pcr: The present invention provides a fluid transfer control method, the method based on measurements of intensities of dyes within the fluid to be transferred. In more detail, the present invention makes use of control dyes and quencher molecules for the fluid transfer controls.... Agent:

20110086338 - Bacteriophage/quantum-dot (phage-qd) nanocomplex to detect biological targets in clinical and environmental isolates: The invention is related to a non-biotinylated bacteriophage that comprises a nucleic acid sequence encoding a biotinylation domain, a complex that comprises a biotinylated bacteriophage and a biotin-specific ligand conjugated bioconjugate, and a method of detecting a bacterial cell in a sample comprising contacting the sample with a non-biotinylated bacteriophage... Agent:

20110086339 - Elimination of pathogenic infection in farmed animal populations: Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd.... Agent:

20110086341 - Fluorinated resorufin compounds and their application: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.... Agent: Life Technologies Corporation

20110086340 - Methods, devices, kits and compositions for detecting roundworm: Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a mammalian sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may... Agent: Divergence, Inc.

20110086361 - Amplification of nuceic acids using temperature zones: The present invention relates to the amplification and detection of amplified nucleic acid sequences employing methods and devices with distinct temperature zones. The methods and devices of the present invention may be used for quantitative analysis of target nucleic acid sequences, for simultaneous quantitative analysis of multiple target nucleic acid... Agent: Koninklijke Philips Electronics N.v.

20110086355 - Brca1 mrna expression levels predict survival in breast cancer patients treated with neoadjuvant chemotherapy: The invention relates to methods for predicting the clinical outcome of a patient which suffers from breast cancer based on the expression levels of BRCA1, wherein low BRCA1 expression levels are indicative of a good prognosis. Moreover, the invention relates to methods for predicting the response to a neoadjuvant therapy... Agent: Pangaea Biotech, S.a.

20110086347 - Cell detection, monitoring and isolation method: The present invention relates generally to a method for identifying or distinguishing one type of cell from other cells within a population of cells. The present invention further provides the detection, monitoring and isolation of sub-populations cell types within a population of cells including a biological entity comprising such cell... Agent: Murdoch Childrens Research Institute

20110086350 - Elimination of pathogenic infection in farmed animal populations: Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd.... Agent:

20110086351 - Elimination of pathogenic infection in farmed animal populations: Animal husbandry has always been susceptible to the ravages of pathogenic infections. Poultry flus and cattle diseases are but two examples that have dire consequences for animals and adversely affect the economic fortunes of farmers. A testing and culling methodology is presented that can eliminate pathogens from an infected herd.... Agent:

20110086342 - Hepatocellular carcinoma-associated gene: i

20110086353 - Identification of micrornas (mirnas) in fecal samples as biomarkers for gastroenterological cancers: A simple, rapid, inexpensive, and promising commercial biomarker assay method for multiple diseases is described herein. The present invention detects miRNA-based biomarkers in human stool specimens. The method of the present invention amplifies miRNA directly from stool specimens without any prior miRNA extraction. Differential expression of specific microRNAs in stool... Agent: Baylor Research Institute

20110086345 - Isolation and use of ryanodine receptors: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial... Agent: E. I. Du Pont De Nemours And Company

20110086352 - Label free detection of nucleic acid amplification: Provided are methods and devices for label-free detection of nucleic acids that are amplified by polymerase chain reaction. A solution containing the components necessary for a PCR is introduced to a microfluidic amplification chamber and an electric field applied to a confined region in which PCR occurs. PCR product generated... Agent:

20110086359 - Lateral flow assays: Assays and methods including mobile tagged single stranded nucleic acid reagents pre-loaded on an analysis device, which are preferably tagged, but not labeled and are complementary to a strand (preferably the anti-sense strand in double stranded DNA targets) of the target nucleic acid. The assay also includes a running buffer... Agent: Rapid Pathogen Screening, Inc.

20110086348 - Method for assessing heart disease: A method for assessing heart disease in a subject includes generating an expression profile of at least two or more miRNAs in a sample from the subject. The miRNAs can be selected from the group consisting of hsa-miRNA-1, hsa-miRNA-7, hsa-miRNA-29b, has-miRNA-125b, hsa-miRNA145, hsa-miRNA-181b, hsa-miRNA-214, hsa-miRNA-342, hsa-miRNA-378 and combinations thereof.... Agent: The Cleveland Clinic Foundation

20110086360 - Method for detection of idiopathic interstitial pneumonia: The present invention provides a method for detecting idiopathic interstitial pneumonia, which comprises measuring the expression level of a periostin gene or the amount of a periostin protein in a biological sample. Thereby, a method for detecting idiopathic interstitial pneumonia using a marker is provided.... Agent:

20110086356 - Method for measuring dna methylation: The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on.... Agent: Sumitomo Chemical Company, Limited

20110086343 - Method for the screening of bacterial isolates: Present invention relates to a method to determine the genotype of organisms by RAPD analysis and more specifically, to establish the relatedness of individual organisms across and within species. RAPD uses genotypic information of an organism to give an organism specific DNA fragment of different sizes. The present invention provide... Agent:

20110086354 - Methods and compositions for multiplex pcr amplifications: The present invention concerns in general PCR reaction mixtures comprising a mixture of hot-start primers and non-hot-start primers for a given target sequence, including multiplex PCR reaction mixtures; methods utilizing same for detection of one or more target polynucleotide sequences; and kits comprising same.... Agent:

20110086357 - Methods for evaluating a disease condition by nucleic acid detection and fractionation: This invention relates to the discovery that both non-particle and particle associated nucleic acids are present in blood plasma and serum and can be used to evaluate disease conditions.... Agent: The Chinese University Of Hong Kong

20110086344 - Methods of characterizing small nucleic acid molecules: The invention generally relates to methods of characterizing small nucleic acid molecules, such as plasmids or nucleic acid molecules obtained from a virus. In certain embodiments, the invention provides a method of characterizing a small circular nucleic acid molecule, the method including performing rolling circle amplification on a small circular... Agent: Opgen, Inc.

20110086346 - Novel haplotype tagging single nucleotide polymorphisms and use of same to predict childhood lymphoblastic leukemia: The present invention is directed to novel haplotype tagging single nucleotide polymorphisms (SNPs) in specific regions outside the HFE gene that serve as a reliable biomarker for a decreased risk for childhood lymphoblastic leukemia (ALL) in a child. There is provided herein methods and reagents for assessing the haplotype tagging... Agent: Medical Diagnostic Laboratories LLC

20110086358 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Canon Kabushiki Kaisha

20110086349 - Proliferation signatures and prognosis for gastrointestinal cancer: This invention relates to methods and compositions for determining the prognosis of cancer in a patient, particularly for gastrointestinal cancer, such as gastric or colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as gastric or colorectal cancer,... Agent:

20110086364 - Detection of cannabis use: A binding partner, especially an antibody fragment that specifically recognizes an antigen-antibody immune complex between anti-THC and THC (tetrahydrocannabinol), is disclosed. The binding partner facilitates a non-competitive homogenous immunoassay for detection of cannabis use. A test kit comprising the binding partner is also described. Preferably the immunoassay is applied for... Agent: Teknologian Tutkimuskeskus Vtt

20110086362 - High-throughput method for quantifying sialylation of glycoproteins: Provided herein methods and kits for detecting and/or quantifying sialic acid content of glycosylated molecules that does not require purification of the glycosylated molecule of interest or purification of the labeled product. The methods and kits provided herein are fast and suitable for high-throughput use.... Agent: Massachusetts Institute Of Technology

20110086363 - Method and apparatus to conduct kinetic analysis of platelet function in whole blood samples: Adhesion of platelets to blood vessel walls is the first step that promotes arrest of bleeding by interaction of the platelet receptors with various extracellular matrix proteins that become exposed on vascular injury. A flow chamber is provided for use in analyzing or studying platelet function, in whole blood, either... Agent:

20110086366 - Methods for assessing the risk of adverse events upon treatment with igg4 antibodies: The invention relates to methods and kits for assessing the risk, for an individual, of developing an adverse event upon treatment with a therapeutic antibody which is capable of Fab-arm exchange, said method comprising the steps of: a) providing a sample from an individual who is a candidate for treatment... Agent: Genmab A/s

20110086368 - Method for immune response detection: A method for detecting one or more immunological response factors that is expressed in response to a therapeutic treatment and/or disease using a piezoelectric microcantilever sensor (PEMS) to assess a patient's immunological response. The method involves measuring a frequency shift of the PEMS caused by binding the immunological response factors... Agent: Drexel University

20110086367 - Pharmaceuticals for influencing the reaction of the human immune system: The present invention uses the potency and efficacy of human glycoprotein-A repetitions predominant protein (GARP), the gene of which is located on chromosome 11q13-11q14 in the reprogramming of antigen-specific effector T-helper cells, which are CD4+, towards a regulatory pheno type of pre-determined suppressor activity. In contrast to the known regulatory... Agent: Helmholtz-zentrum Fur Infektionsforschung Gmbh

20110086369 - Fluorescent compounds for the diagnosis of infections, production method, and applications thereof: The present invention describes novel fluorescent compounds analogous to alkyl phospholipids, containing highly photostable fluorescent groups in the structure thereof and emitting in the visible spectrum wavelength zone. Said compounds are easily introduced to microorganisms, enabling the detection and identification of these organisms by means of fluorescence microscopy. The novel... Agent:

20110086370 - Protease detection: A polypeptide comprising a chromogenic amino acid. The chromogenic amino acid is flanked by at least one amino acid to the N and C termini thereof. The amine group of the chromogenic amino acid has a pKa of less than 5. The chromogenic amino acid is capable of reacting with... Agent: Mologic Ltd

20110086365 - Method for sensing a chemical: The present invention relates to a method for detecting an analyte (10) in a sample, comprising the steps of: providing a transducer (3) having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, a first reagent (9) immobilised on... Agent: Vivacta Ltd.

20110086372 - Biomarkers associated with nephropathy: Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.... Agent: Industrial Technology Research Institute(itri)

20110086371 - Urine and serum biomarkers associated with diabetic nephropathy: Use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.... Agent: Industrial Technology Research Institute(itri)

20110086373 - Cholesterol sensor: A method for the determination of the amount of cholesterol in a sample is provided. The method typically provides a breakdown of the HDL and LDL cholesterol contents of the sample.... Agent:

20110086374 - Novel cell-based phosphodiesterase assays: The present invention relates to improved cell-based assays for the in vivo assessment of phosphodiesterase (PDE) activity using cyclic nucleotide-gated channels as cyclic nucleotide sensors, and for the assessment of the effect of PDE modulating compounds.... Agent:

20110086377 - Bead manipulations on a droplet actuator: A droplet actuator comprising: (a) a base substrate comprising electrodes configured for conducting droplet operations on a droplet operations surface thereof; (b) a droplet comprising one or more beads situated on the droplet operations surface; (c) a barrier arranged in relation to the droplet and the electrodes such that a... Agent: Advanced Liquid Logic, Inc.

20110086378 - Cartridge for a biological sample: An assay device comprising a compartment adapted to receive a sealed removable cartridge, wherein said cartridge is adapted to contain a biologic sample and internally comprises two or more assay locations, wherein said cartridge is adapted to facilitate two or more assays of said biologic sample; and an actuator adapted... Agent:

20110086380 - Device for storing a biological sample and for preparing the biological sample: A device for storing a biological sample (3) and allowing transfer of heat for disrupting secondary structures of the biological sample (3) is disclosed. It comprises a biological sample carrier (5) having a portion (7). The portion (7) is intended for receiving a biological sample (3). It also comprises at... Agent: Denator Aktiebolag

20110086375 - Devices and methods for production of cell aggregates: The present application provides methods and devices for the production and recovery of cell aggregates. In one embodiment, the device is a microwell device with a high density of microwells. The application also provides a device for extracting cell aggregates such as stem cells or embryoid bodies from well plates.... Agent:

20110086376 - In-vivo platelet function test by online bleeding volume measurement: A method for remotely determining a patient's excessive bleeding tendency and a patient's resistance to blood thinning medication is disclosed. An incision is made in the patient's forearm. Blood oozing out of the incision is absorbed into a blotter paper until the bleeding stops. Blotches of blood formed on the... Agent:

20110086381 - Method for evaluation of function of phagocyte: A novel convenient method for evaluating the function of a phagocyte is provided. The method assays sCD14-ST, which is a humoral factor specifically produced in phagocytosis by the phagocyte and which is stable enough for use in an assay. Also provided is a method for detecting diseases associated with the... Agent: Mochida Pharmaceutical Co., Ltd.

20110086379 - Method of differentiating stem cells: The present disclosure provides methods of generating germ layers from stem cells comprising culturing the stem cells in a culture medium having an osmolality less than 340 mOsm/kg. The present disclosure also includes a method to generate different cell lineages from the germ layers as well as to detect them... Agent:

20110086382 - Organ-on-a-chip-device: A self-contained organ-on-a-chip device includes at least one medium feed reservoir and at least one organ growth section including at least one organ cavity. The at least one medium feed reservoir is configured to connect to the at least one organ growth section by a microfluidic feed channel and the... Agent:

20110086383 - Apparatus and methods for treating allograft products: Apparatus for treating allografts, having a sonication tank configured to transmit ultrasonic energy to the interior of the tank; a treatment canister rotatably positioned in said sonication tank, and configured to receive allografts therein; and a treatment fluid source in fluid communication with said treatment canister. Methods of treating allografts... Agent: Allosource

20110086384 - Identification of bacterial species and subspecies using lipids: The use of free, extractable lipids found in bacteria for identification of bacterial species and subspecies is described. Bacteria have been found to differ sufficiently in their extracted lipid compositions to effect identification using thin layer chromatographic techniques. Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei have been distinguished in this... Agent: Colorado State University Research Foundation

20110086385 - Process for the production of biogas: A container (1) for the fermentative production of biogas from organic substrates, which container comprises an axial stirrer (9), one or several inlet devices (2) for filling the container (1), one or several outlet devices (3, 4) for emptying the container (1) and withdrawing a fermentation residue, an external conduit... Agent: Enbasys Gmbh

20110086386 - Algae biomass fractionation: A method of fractionating biomass, by permeability conditioning biomass suspended in a pH adjusted solution of at least one water-based polar solvent to form a conditioned biomass, intimately contacting the pH adjusted solution with at least one non-polar solvent, partitioning to obtain an non-polar solvent solution and a polar biomass... Agent:

20110086388 - Chaperone-assisted protein expression and methods of use: The present disclosure provides methods of utilizing chaperone proteins for the production of active protein such as those encoded by the genes of natural biosynthetic clusters. The methods provided herein have applicability for a wide variety of genes ranging from small fatty acid biosynthetic genes to large non-ribosomal peptide synthetase... Agent: Duke University

20110086389 - Compositions and methods for expressing in-frame multimeric proteins: The present invention concerns methods and compositions for making and using multimeric, single chain proteins of a defined structure. In various embodiments the invention involves a bank or collection of one or more monomer nucleic acid species with each such nucleic acid species encoding a protein monomer subunit species and... Agent:

20110086391 - Expression vector: An expression vector for expressing a target polypeptide in a prokaryotic cell is provided. The vector comprises a promoter operably linked to a polynucleotide encoding the target polypeptide operably linked to a eukaryotic secretion leader sequence, the eukaryotic secretion leader sequence encoding a signal peptide sequence selected from the group... Agent:

20110086387 - Mutant nanoarchaeum equitans a523r dna polymerase and its use: Disclosed herein is a mutant Neq A523R DNA polymerase consisting of an amino acid sequence of SEQ ID NO: 2 wherein alanine at amino acid position 523 in a Nanoarchaeum equitans DNA polymerase (Neq DNA polymerase) consisting of an amino acid sequence of SEQ ID NO: 1 has been substituted... Agent:

20110086390 - Product and process for transformation of thraustochytriales microorganisms: Disclosed are nucleic acid and amino acid sequences for acetolactate synthase, acetolactate synthase regulatory regions, α-tubulin promoter, a promoter from a Thraustochytriales polyketide synthase (PKS) system, and fatty acid desaturase promoter, each from a Thraustochytriales microorganism. Also disclosed are recombinant vectors useful for transformation of Thraustochytriales microorganisms, as well as... Agent: Martek Biosciences Corporation

20110086393 - Method to produce single stranded dna of defined length and sequence and dna probes produced thereby: A method for producing a single stranded DNA (ssDNA) molecule of a defined length and sequence is disclosed. This method enables the preparation of, inter alia, probes of greater length than can be chemically synthesized. The method starts with a double stranded molecule, such as genomic, double stranded DNA (dsDNA)... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20110086392 - Methods for repairing degraded dna: The present invention provides methods and kits for repair of degraded DNA which may then be used as a template for efficient amplification by a number of different amplification reactions. The method relies upon a series of enzymatic activities provided by DNA repair enzymes.... Agent: Ibis Biosciences, Inc.

20110086394 - Nucleic acid amplification: The present invention provides methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mRNA, using oligonucleotides, DNA and RNA polymerases are provided. The invention further provides compositions and kits for practicing the methods, as well as methods which use the amplification products.... Agent:

20110086395 - Novel microorganism and its use in lignocellulose detoxification: An isolated microorganism is provided which is Cupriavidus basilensis strain HMF14 Deposit number DSM 22875, and its use in a process for the in-situ detoxification of lignocelluloses hydrolysate.... Agent:

20110086396 - D-amino acid oxidase, and method for production of l-amino acid, 2-oxo acid, or cyclic imine: The present invention relates to novel D-amino acid oxidase isolated and purified from Candida intermedia, a gene encoding the D-amino acid oxidase, a recombinant plasmid containing the gene, and a transformant into which the D-amino acid oxidase gene has been introduced, as well as a production method of D-amino acid... Agent: Kaneka Corporation

20110086397 - Enhanced production of taxol and taxanes by cell cultures of taxus species: This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been... Agent: Phyton Holdings, LLC

20110086398 - Cellular production of hydroxyvalerates from levulinate: The invention relates to cells that recombinantly express tesB and produce one or more hydroxyacids such as 3-hydroxyvalerate (3HV) and/or 4-hydroxyvalerate (4HV).... Agent:

20110086399 - Recovery of stilbenoids: A cis- or trans-stilbenoid of the general formula (1) in which each of R1, R2, R3, R4 and R5 is hydrogen or hydroxy, or a glycosylated or oligomeric form thereof, such as resveratrol or pinosylvin is produced by cultivating a microorganism such as a genetically engineered yeast to produce said... Agent: Fluxome Sciences A/s

20110086402 - Engineering of xylose reductase and overexpression of xylitol dehydrogenase and xylulokinase improves xylose alcoholic fermentation in the thermotolerant yeast hansenula polymorpha: Recombinant genetic constructs and strains of H. polymorpha having significantly increased ethanol productivity with a simultaneous decreased production of xylitol during high-temperature xylose fermentation are disclosed. The constructs include a H. polymorpha XYL1 gene encoding xylose reductase mutated to decrease affinity of the enzyme toward NADPH. The modified version of... Agent:

20110086400 - Method and system for collecting ethanol from aquatic plants: Methods and systems for collecting, purifying, and/or extracting ethanol produced during anaerobic metabolism by aquatic plants is provided. The system includes a cell containing water and an aquatic plant, an ethanol extraction assembly in fluid communication with the cell for removing ethanol from the water. Ethanol is released by the... Agent: Aquatech Bioenergy LLC

20110086401 - Method and system for collecting ethanol from aquatic plants: Methods and systems for collecting, purifying, and/or extracting ethanol produced during anaerobic metabolism by aquatic plants is provided. The system includes a cell containing water and an aquatic plant, an ethanol extraction assembly in fluid communication with the cell for removing ethanol from the water. Ethanol is released by the... Agent: Aquatech Bioenergy LLC

20110086403 - Photoinhibition of microbial nitrification in potable water: A system for the photo-inhibition of microbial nitrification of potable water may include overhead, floating or submerged lamps (fluorescent, incandescent, LED, etc. . . . ) with spectral emission between 315-430 nm, headspace and submerged light meters for measuring the intensity above and below the water surface, a water mixing... Agent:

20110086404 - Method for monitoring, diagnosing, and screening cancer through measuring the concentration of des-r prothrombin activation peptide fragment f2 (des-r f2) in a serum: The present invention relates to a method for diagnosis and screening of cancer by measuring the expression of des-R prothrombin activation peptide fragment F2 (des-R F2) in serum, more precisely, des-R-prothrombin activation peptide fragment F2 which is the protein marker down-regulated specifically in liver cancer, breast cancer, and stomach cancer,... Agent: Bioinfra Inc.

20110086405 - Method for producing hydroxylated adamantane using cytochrome p450: Disclosed is a method for producing a hydroxylated form of a compound having an adamantane skeleton, which is useful as an intermediate for functional resins and pharmaceutical products, with high yield and at low cost. Specifically, a hydroxylated form of a compound having an adamantane skeleton can be obtained by... Agent:

20110086407 - Bacillus licheniformis chromosome: The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods... Agent: Novozymes, Inc.

20110086406 - Chimeric polymerases: Disclosed herein are chimeric polymerases and methods of making and using same.... Agent: Life Technologies Corporation

20110086408 - Hemicellulase enriched compositions for enhancing hydrolysis of biomass: Described are compositions and methods relating to cellulase/hemicellulase enzyme blends for improving the enzymatic hydrolysis of cellulosic and hemicellulosic materials, as commonly found in biomass... Agent: Danisco US Inc.

20110086409 - Surfactant-based monolithic columns, methods for making the same, and method for using the same: A method for making a surfactant-based monolithic column is provided. The method comprises providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen and polymerizing the mixture to form the surfactant-based monolithic column. The present disclosure also provides... Agent:

20110086410 - Bgl4 beta-glucosidase and nucleic acids encoding the same: The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl4, and the corresponding BGL4 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL4, recombinant BGL4 proteins and methods for producing the same.... Agent:

20110086411 - Method of producing a polypeptide or virus of interest in a continuous cell culture: Described herein is a chemostat-like continuous cell culture system that combines certain advantages of perfusion open systems and chemostat open systems to improve the culturing of mammalian cells, e.g., genetically modified cells, particularly in serum-free or chemically-defined media. The continuous culture system described herein involves culturing mammalian cells in a... Agent: Baxter International Inc.

20110086413 - Cell culture medium for adamts protein expression: The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high... Agent: Baxter Healthcare S.a.

20110086412 - Multiply-substituted protease variants: Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino... Agent: Danisco US Inc.

20110086414 - Prion disinfection: The invention relates to a methods and compositions for treating a surface, suspension or solution contaminated with a PrPSc prion protein or a surrogate thereof. The methods and compositions employ a combination of one or more enzymes effective to cleave a prion protein to fragments having a non-infective molecular weight,... Agent: Novapharm Research (australia) Pty Ltd.

20110086415 - Electrospun fiber pre-concentrator: The present disclosure relates, in some embodiments, to pre-concentrator compositions, devices, systems, and/or methods for concentrating small quantities of chemical or biological compounds, e.g., CBRNE compounds. A pre-concentrator of the disclosure may be operable to releasably bind and concentrate CBRNE compounds. In some embodiments, a pre-concentrator may comprise a 3-D... Agent:

20110086416 - Immunotoxin fusion proteins and means for expression thereof: The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be expressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein.... Agent: The Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services

20110086417 - Apparatus and method for using a brine solution to freeze biopsy material: Apparatus and method for freezing biopsy material. The apparatus includes a container that includes an inner wall and an outer wall defining a space therebeween for receiving a material adapted to withstand a temperature below −20° F. The apparatus further includes a cooling insulating medium that is disposed between the... Agent:

20110086418 - Highly sensitive oxygen sensor for cell culture: An oxygen sensor comprising an oxygen sensing compound and configured to substantially mitigate leaching of the oxygen sensing compound from the oxygen sensor to an outer surface thereof is provided. The oxygen sensor may comprise one or more layers. A first portion of the oxygen sensor is configured to be... Agent: National Institute Of Standards And Technology, U.s. Department Of Commerce

20110086419 - Method and system for collecting ethanol from aquatic plants: Methods and systems for collecting, purifying, and/or extracting ethanol produced during anaerobic metabolism by aquatic plants is provided. The system includes a cell containing water and an aquatic plant, an ethanol extraction assembly in fluid communication with the cell for removing ethanol from the water. Ethanol is released by the... Agent: Aquatech Bioenergy LLC

20110086420 - Polymer substrate with fluorescent structure, method for the production thereof and the use thereof: The invention relates to polymer substrates which are provided with fluorescence features and in which photochemical fluorescence features, i.e. fluorescent structures, are produced by UV irradiation. Thus, fluorophores can be produced in polymer substrates with a low inherent fluorescence by means of suitable UV radiation, which fluorophores display a marked... Agent: Ibidi Gmbh

20110086421 - Use of biological photoreceptors as directly light-activated ion channels: Use of a biological photoreceptor as light-controlled ion channel for the alteration of the ion conductivity of a membrane by means of light. The photoreceptor used comprises an apoprotein and a light-sensitive polyene covalently bound to the apoprotein, said polyene interacting with the apoprotein and functioning as a light-sensitive gate.... Agent: Max-planck-gesel.zur Foerderung Der Wissen. E.v.

20110086422 - Humanized antibodies to interferon alpha receptor-1 (ifnar-1): Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.... Agent:

20110086423 - Cellular targets for treatment of retroviral infection: Cellular targets for anti-retroviral drug development are disclosed. The cellular targets comprise ATR kinase and its relevant substrates, based on the identification of the ATR kinase as required for the final step of retroviral DNA integration. Assays for identifying modulators of retroviral integration via the ATR kinase pathway are disclosed,... Agent: Fox Chase Cancer Center

20110086424 - Methods for producing enucleated erythroid cells derived from pluripotent stem cells: Methods for generating enucleated erythroid cells using pluripotent stem cells are provided. The methods permit the production of large numbers of cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Methods for generating megakaryocyte and platelets are also provided.... Agent: Advanced Cell Technology, Inc.

20110086425 - Delivery of sirnas: The present invention provides siRNA delivery methods use in vivo or in vitro. The delivery methods include conjugation with delivery peptides and mixing with dendrimers.... Agent:

20110086426 - Methods and apparatus for collecting and separating regenerative cells from adipose tissue: Methods and apparatus for: collecting adipose tissue in a syringe; subjecting the collected adipose tissue to heat, vibration, and or centrifugation whilst remaining within the syringe; and filtering the adipose tissue during centrifugation such that the regenerative cells are permitted to pass into a reservoir of a collection sleeve.... Agent: Lipostem Corp.

20110086427 - Microfluidic device for cell culture: A microfluidic cell culture apparatus includes a cell retention chamber and a perfusion channel. The cell retention chamber has a structured surface. The structured surface includes a major surface from which a plurality of projections extends into the chamber. The plurality of projections are arranged to suspend cells cultured in... Agent:

  
04/07/2011 > patent applications in patent subcategories. category listing, related patent applications

20110081641 - Method and apparatus for automating chemical and biological assays: A device which collects specimen fluids or performs chemical or biological assays of the specimen fluid is provided with a specimen fluid receiver and a fluid actuated trigger coupled to receive specimen fluid from the specimen fluid receiver. The trigger is made of a material which expands substantially upon absorbing... Agent:

20110081644 - Cell line stably expressing mutated oncoprotein e6 and method of screening anticancer compound of uterine cervical cancer using the same: Disclosed are a cell line that expresses protein of Seq. No. 1, and a method for screening an anticancer compound of uterine cervical cancer by using the same. The stable cell line that expresses oncoprotein E6 of a human papillomavirus type 16 variant strain is used to determine a difference... Agent: Korea Center For Disease Control And Prevention

20110081645 - Compositions and methods for detecting hepatitis b virus: Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers that facilitate detection of very low levels of HBV nucleic... Agent: Gen-probe Incorporated

20110081646 - Dengue virus assay: Nucleic acid assays for detecting nucleic acids of Dengue virus serotypes 1-4.... Agent: Gen-probe Incorporated

20110081643 - Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto: In a method and system for forming concentrated volumes of microbeads, a polymer solution and/or suspension includes a polymer dissolved and/or dispersed in a medium. Streams of a focusing fluid and of the polymer solution and/or suspension flow towards a fluid bath, and into intersection with one another, so &s... Agent:

20110081642 - Selection of b cells with specificity of interest: method of preparation and use: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides methods using a composition comprising an ordered and repetitive antigen or antigenic determinant array for visualization and selection of B cells specific for the antigen. These B cells are useful for the... Agent: Cytos Biotechnology Ag

20110081649 - Diagnosis, staging and monitoring of inflammatory bowel disease: A method of differentiating between active and inactive IBD in a gastrointestinal mucosa sample or a sample from a sentinel lymph node draining gastrointestinal mucosa comprises preparing a suspension of single cells from the sample, analyzing the suspension for expression of the inflammation activation marker CD69 on CD4+ T helper... Agent: Iss Immune System Stimulation Ab

20110081651 - Egfr and kras mutations: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and KRAS and methods of detecting such mutations as well as prognostic methods for identifying tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated... Agent: Genentech, Inc.

20110081650 - Free ngal as a biomarker for cancer: Uncomplexed neutrophil gelatinase associated lipocalin (NGAL) is present at increased levels in individuals with atypical ductal hyperplasia (ADH), a major risk factor for future breast cancer development; in individuals that have ovarian cancer; and in individuals that have breast cancer, both invasive and noninvasive. Accordingly, the present invention is directed... Agent:

20110081653 - High spatial resolution imaging of a structure of interest in a specimen: In high spatial resolution imaging, a structure in a specimen is marked with a substance which, in a first electronic state, is excited by light of one wavelength to emit fluorescent light, which is also converted from its first into a second electronic state by that light, and which returns... Agent: Max-planck-gesellschaft Zur Forderung Der Wissenschaftern E.v.

20110081652 - Method of classifying gene expression strength in lung cancer tissues: The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a... Agent: Fujifilm Corporation

20110081648 - Methods for diagnosing peripheral neuropathy: Genes whose expression is correlated with the presence of CIDP or vasculitic neuropathy are disclosed. Probes and sets of nucleic acids and proteins specific for these genes are described, as are molecular and immunological methods for aiding in the diagnosis of these disease conditions in a subject.... Agent:

20110081655 - Nucleic acid analyzing device and nucleic acid analyzer: An object of the present invention relates to distinguishing, from a fluorophore of an unreacted substrate, a single fluorophore attached to a nucleotide that is incorporated into a probe by a nucleic acid synthesis. The present invention relates to a nucleic acid analyzing device that analyzes a nucleic acid in... Agent:

20110081647 - Nucleotide analogs: The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at... Agent: Helicos Biosciences Corporation

20110081654 - Transcriptional profiling of stem cells and their multilineage differentiation: The present invention concerns methods of screening cells for differentiation or de-differentiation, and/or for status as a pluripotent or multipotent (e.g., “stem”) cell, by detecting the differential expression (e.g., upregulation, downregulation) of genes.... Agent:

20110081657 - Controlled platelet activation to monitor therapy of adp antagonists: A method is provided of determining whether an individual has reduced ability to form platelet thrombi due to inhibition of platelet activation initiation, signal transduction and/or GPIIb/IIIa blockade. A blood sample is obtained from the individual being assessed. The blood sample is mixed in combination with 1) an anticoagulant; 2)... Agent: Accumetrics, Inc.

20110081656 - Secreted proteins and uses thereof: The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further... Agent: Millennium Pharmaceuticals, Inc.

20110081658 - T1r3 binding assays: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent:

20110081661 - Modified photoproteins with increased affinity for calcium and enhanced bioluminescence and uses thereof: The present invention provides modified photoproteins, e.g., modified Clytin, having an increased affinity for calcium as well as an enhanced bioluminescence and their use as calcium indicators in reporter gene systems and in cell-based assays.... Agent: Millipore Corporation

20110081663 - Molecular probe for imaging of pancreatic islets and use of the same: wherein A represents an aromatic hydrocarbon group or an aromatic heterocyclic group; R1 represents a substituent that contains 11C, 13N, 15O, 18F, 64Cu, 67Ga, 68Ga, 75Br, 76Br, 77Br, 99mTc, 111In, 123I, 124I, 125I, or 131I; R2 represents either a hydrogen atom, or a substituent different from that represented by R1;... Agent: Arkray, Inc.

20110081662 - Screening methods for bone morphogenetic mimetics: Disclosed are methods for identifying agents which modulate the activity of bone morphogenetic protein-7. These methods for identifying agents utilize bone morphogenetic protein receptors, specifically the daf-4 receptor, and more specifically the extracellular domain of the daf-4 receptor. Agents identified by the methods are also described as well as compositions... Agent: Thrasos Therapeutics, Inc.

20110081665 - Methods for making cancer prognoses based on subcellular localization of biomarkers: This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.... Agent: Yale University And Historx, Inc.

20110081664 - Multipurpose microfluidic device for mimicking a microenvironment within a tumor: The present application relates generally to a novel microfluidic device for the in it propagation of neoplastic cellagregates under conditions that mimic the physiological microenvironment found in tumors. The invention also describes methods of screening for therapeutic test agents and protocols that target proliferating and quiescent neoplastic cells within tumors.... Agent: University Of Massachusetts

20110081666 - Anti-psgl-1 inhibitors and screening methods: The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both selectin and chemokine binding to PSGL-1 expressed on leukocytes, lymphocytes and endothelial cells and thus which inhibit migration and/or rolling of... Agent:

20110081659 - Substrates for glycogen synthase kinase 3 enzymes and methods of use: Methods and compositions for glycogen synthase kinase 3 assays continue to be required for detection of glycogen synthase 3 kinase, assessment of glycogen synthase 3 kinase activity and identification of modulators of glycogen synthase 3 kinase. Methods and compositions for glycogen synthase kinase 3 assays are provided herein based on... Agent:

20110081660 - Method for detecting misfolded proteins and prions: The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification... Agent: Adlyfe, Inc.

20110081667 - Biomarkers associated with nephropathy: Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.... Agent: Industrial Technology Research Institute(itri)

20110081668 - Biomarkers associated with nephropathy: Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.... Agent: Industrial Technology Research Institute(itri)

20110081669 - Systems and methods for diagnosis and prognosis of cancer: Methods for diagnosing a cancer in a subject are provided that include determining an amount of autoantibodies immunoreactive to procathepsin D (pCD) in a sample obtained from the subject. Further provided are systems for diagnosing a cancer in a subject that include an autoantibody immunoreactive pCD antigen and a means... Agent: University Of Louisville Research Foundation, Inc.

20110081670 - Luciferase-based assays: A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference... Agent: Promega Corporation

20110081671 - Vascular markers in the remodeling of cardiac injury: The present invention is concerned with diagnostic means and methods. More specifically, the present invention relates to a method for diagnosing the angiogenic status of a subject suffering from myocardial infarction comprising determining the amounts of P1GF, sFLT1 and endoglin in a first sample of a subject obtained after myocardial... Agent:

20110081672 - Process control of biotechnological processes: A biotechnological process for conversion of a raw material (100, 200) to a desired product (130, 230) by means of one or more biological or biochemical agents (102, 104, 202) such as microorganisms and/or enzymes characterised in that the amount of one or more of said biological or biochemical agents... Agent:

20110081673 - Diagnostic gum for screening diabetes: A diagnostic chewing gum for identifying a risk for diabetes includes a mixture of an enzyme, a conjugated protein of the glucose enzyme, a substrate, and a gum base. The enzyme and the conjugated protein facilitate a conversion of the substrate to produce a detectable signal in the presence of... Agent:

20110081674 - Continuous-flow deformability-based cell separation: This invention provides methods utilizing a microfluidic device that can quickly and accurately discern differences in deformability between individual cells and sets of cells and continuously fractionate populations of cells based on their deformability. This information may be important in disease diagnosis and treatment efficacy monitoring. For example such a... Agent:

20110081675 - Metabolic biomarkers of drug-induced cardiotoxicity: The invention provides methods and biomarkers for assessing cardiac metabolic response to pharmaceuticals, environmental agents, chemical compounds and biologic therapies. The invention provides methods for identifying cellular metabolites secreted by primary cardiomyocytes, cardiomyocyte precursor cells, clonal cardiomyocytes derived from adult human heart, immortalized cardiomyocytes, human embryonic stem cell (hESC)-derived cardiomyocytes,... Agent: Stemina Biomarker Discovery, Inc.

20110081676 - Rapid detection of viable bacteria system and method: An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies... Agent: The Curators Of The University Of Missouri

20110081677 - Active microfluidic membranes: The present invention relates to a biofabricated Active Microfluidic Membrane (AMM) in a microfluidic network of a microfluidic device and a method for the in situ biofabrication of such a microfluidic network. More specifically, the invention relates to devices exhibiting (and methods of) positioning (i.e., erecting, modifying or removing a... Agent: University Of Maryland, College Park

20110081678 - Method for producing beta-alanyl-amino acid or derivative thereof: The present invention provides a method for efficiently producing a β-alanyl-amino acid (e.g., carnosine) or derivative thereof. Specifically, it provides a method for producing a β-alanyl-amino acid (e.g., β-alanyl-histidine) or derivative thereof, by reacting a β-alanyl ester or a β-alanyl amide and an amino acid or derivative thereof in the... Agent:

20110081680 - Animal protein-free media for cultivation of cells: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating... Agent: Baxter Healthcare S.a.

20110081679 - Mammalian cell culture processes for protein production: The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, preferably, but not limited to, fed-batch cell cultures. In one aspect, the methods comprise the addition of glucocorticoid compound during the culturing period. The addition of glucocorticoid compound sustain... Agent: Bristol-myers Squibb Company

20110081681 - Human antibodies to human cd20 and method of using thereof: A human antibody or antigen-binding fragment of an antibody that specifically binds human CD20 and is capable of inducing complement dependent cytotoxicity (CDC), and is capable of increasing symptom free survival time between about 2-fold to about 9-fold or more, relative to control-treated animals in a mouse model of human... Agent: Regeneron Pharmaceuticals, Inc.

20110081682 - Production of bone morphogenic proteins (bmps) using a novel tissue culture platform: The present disclosure provides methods for producing Bone Morphogenetic Proteins (BMPs). The BMPs are produced using ex vivo-derived mineralized three-dimensional bone constructs of varying degrees of maturity and mineralization. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions whereupon the bone constructs secrete... Agent: Osteosphere, LLC

20110081683 - Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes: A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide involved in at least partially degrading, cleaving, transporting, metabolizing, or removing polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin,... Agent: Battelle Energy Alliance, LLC

20110081684 - Method for carrying out an enzymatic reaction: The invention relates to a method for carrying out an enzymatic reaction, in particular for carrying out a polymerase chain reaction (PCR). Said method consists of the following steps: at least one eukaryotic cell is removed from a starting material; the cell core or cores of the eukaryotic cell(s) is/are... Agent:

20110081685 - Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction: The present invention concerns preparation of DNA molecules, such as a library, using a stem-loop oligonucleotide. In particular embodiments, the invention employs a single reaction mixture and conditions. In particular, at least part of the inverted palindrome is removed during the preparation of the molecules to facilitate amplification of the... Agent: Rubicon Genomics, Inc.

20110081687 - Enrichment through heteroduplexed molecules: The present invention relates to the enrichment of specific target sequences. Enrichment can be achieved through the formation of a heteroduplex that includes the specific target sequence and then the specific cleavage of the heteroduplex. A binding moiety is then added to the cleaved heteroduplex, allowing for the subsequent manipulation... Agent: Life Technologies Corporation

20110081686 - Reactor for bulk manufacture of pcr amplicons: A reactor and methods of use are disclosed for amplification of an amplicon. The reactor includes a housing having a fluid path with a fluid inlet and a fluid outlet and one or more reaction chambers suitable for housing the amplicon. The reaction chambers are positioned within the housing in... Agent: Vical Incorporated

20110081688 - Water-soluble rhodamine dyes conjugates: The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining... Agent: Life Technologies Corporation

20110081689 - Process for thermal-mechanical pretreatment of biomass: Disclosed is a process for the thermal-mechanical pretreatment of biomass. The process includes subjecting a biomass feedstock including fibers containing cellulose, hemicellulose and lignin, to thermal reaction under conditions exceeding atmospheric pressure, at a temperature exceeding ambient temperature, at a predetermined moisture content and for a predetermined amount of time.... Agent: Kl Energy Corporation

20110081690 - Sustainable method for synthesizing tetrodotoxin (ttx): A sustainable biosynthesizing of tetrodotoxin (TTX) based on seed culture of Vibrio spp is obtained from the mucus of various species of nemerteans (ribbon worms) (phylum Nemertea). The indispensable organisms are kept alive which extends access to crude material and makes the procedure economically and ecologically sustainable.... Agent:

20110081691 - Gene that increases production of plant fat-and-oil and method for using the same: This invention is intended to search for a transcription regulator having a novel function of improving the amount of substances produced per individual plant and to enhance such properties in a plant. A chimeric protein resulting from the fusion of a transcription factor belonging a transcription factor family that includes... Agent: National Institute Of Advanced Industrial Science And Technology

20110081692 - Polyhydroxyalkanoic acid copolymer and process for preparing same: A polyhydroxyalkanoic acid copolymer comprising at least (R)-3-hydroxy-4-methyl valeric acid units; and a method of producing a polyhydroxyalkanoic acid copolymer comprising at least (R)-3-hydroxy-4-methyl valeric acid units, wherein in the presence of a carbon source and a precursor of (R)-3-hydroxy-4-methyl valeric acid, a transformant in which the gene of polyhydroxyalkanoic... Agent: Tokyo Institute Of Technology

20110081693 - Perhydrolase for enzymatic peracid production: A process is provided for rapidly producing target concentrations of peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with a source of peroxygen, such as hydrogen peroxide, in the presence of an enzyme catalyst comprising an enzyme having identity to an acetyl xylan esterase from... Agent:

20110081694 - Dicarboxylic acid production in eukaryotes: The present invention relates to a recombinant eukaryotic microbial cell comprising a nucleotide sequence encoding a heterologous enzyme catalysing the conversion from phosphoenolpyruvate to oxaloacetate whereby ATP is generated. The invention further relates to a process for the preparation of a dicarboxylic acid such as succinic acid and fumaric acid,... Agent:

20110081695 - Method for processing molasses: A method of processing residual molasses from a procedure for the production of lactose from whey permeate. From this molasses, a mineral diminished component is extracted, concentrated, crystallized and therefrom a crystallized phase is separated.... Agent: Molkerei Alois Muller Gmbh & Co. Kg

20110081696 - Polypeptides having cellobiohydrolase ii activity and polynucleotides encoding same: The present invention relates to polypeptides having cellobiohydrolase II activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.... Agent: Novozymes A/s

20110081697 - Progressive fermentation of lignocellulosic biomass: Provided are methods for the efficient and cost-reduced production of ethanol or other fermentation products or both from cellulosic biomass, which methods exploit the optimal features of yeasts, fungi, and bacteria while simultaneously minimizing their limitations. For example, one aspect of the present invention relates to methods of producing ethanol... Agent:

20110081698 - Method and introduction of gene into yeast cell, and vector for the method: An object of the present invention is a method for introducing a foreign gene into a yeast cell that does not have an auxotrophic marker. The present invention provides a method for providing a target auxotrophy to a yeast cell and introducing a gene to be expressed into the yeast... Agent: Kansai Chemical Engineering Co., Ltd.

20110081699 - Nitrate reduction by a probiotic in the presence of a heme: The invention relates to a method for reducing nitrate into nitrite wherein a probiotic and/or starter bacteriumis cultivated under anaerobic conditions in the presence of a nitrate, a heme and optionally a vitamin K.... Agent:

20110081700 - Methods of purifying recombinant adamts13 and other proteins and compositions thereof: Provided herein are methods for purifying recombinant A Disintegrin-like and Metallopeptidase with Thrombospondin Type 1 Motif 13 (ADAMTS13) protein from a sample. The method comprises enriching for ADAMTS13 protein by chromatographically contacting the sample with hydroxyapatite under conditions that allow ADAMTS13 protein to appear in the eluate or supernatant from... Agent: Baxter International Inc.

20110081701 - Surgical compositions: The present disclosure relates to methods of cell encapsulation using multi-component hydrogels. The hydrogels may include a natural component having nucleophilic functional groups as well as an electrophilic component. In embodiments, at least one of the components may be branched, having drugs, antibodies, enzymes, and the like incorporated therein, which... Agent:

20110081702 - Method for the production of proteins: The present invention relates to a process for the purification of a protease.... Agent: Novo Nordisk Healthcare A/g

20110081703 - Chimeric isoprenoid synthases and uses thereof: Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of... Agent:

20110081704 - Thermostable reverse transcriptases and uses thereof: The present invention is in the fields of molecular and cellular biology. The invention is generally related to reverse transcriptase enzymes and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to reverse transcriptase enzymes which have been mutated or modified to... Agent: Life Technologies Corporation

20110081705 - Recombinant elastase proteins and methods of manufacturing and use thereof: The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described... Agent:

20110081706 - Method and system for efficient harvesting of microalgae and cyanobacteria: The high-speed centrifugation heretofore required for harvesting micro algae and cyanobacteria cultured for biofuels and other co-products is a major cost constraint. Mixing algae/cyanobacteria at high-density culture with far less alkali than previously assumed is sufficient to flocculate the cells. The amount of flocculant required is a function of the... Agent: Transalgae Ltd

20110081707 - Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor: Carbohydrate utilization-related and multidrug transporter nucleic acids and polypeptides, and fragments and variants thereof, are disclosed in the current invention. In addition, carbohydrate utilization-related and multidrug transporter fusion proteins, antigenic peptides, and anti-carbohydrate utilization-related and anti-multidrug transporter antibodies are encompassed. The invention also provides vectors containing a nucleic acid of... Agent: North Carolina State University

20110081708 - Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm: An improved gene sequence optimization method, the systematic optimization method, is described for boosting the recombinant expression of genes in bacteria, yeast, insect and mammalian cells. This general method takes into account of multiple, preferably most or all, of the parameters and factors affecting protein expression including codon usage, tRNA... Agent: Genscript Holdings (hong Kong) Limited

20110081709 - Method and apparatus for extracting carbon dioxide from air: A method and apparatus for extracting CO2 from air comprising an anion exchange material formed in a matrix exposed to a flow of the air, and for delivering that extracted CO2 to controlled environments. The present invention contemplates the extraction of CO2 from air using conventional extraction methods or by... Agent:

20110081710 - Method and apparatus for extracting carbon dioxide from air: A method and apparatus for extracting CO2 from air comprising an anion exchange material formed in a matrix exposed to a flow of the air, and for delivering that extracted CO2 to controlled environments. The present invention contemplates the extraction of CO2 from air using conventional extraction methods or by... Agent:

20110081711 - Streptomyces protease: Certain aspects of this disclosure relate to an isolated protease, and cleaning compositions containing the same. In some embodiments, the protease may comprise an amino acid sequence that is at least 80% identical to the wild type Streptomyces 1AG3 protease. Isolated nucleic acid encoding the subject protease, recombinant nucleic acid... Agent:

20110081712 - Method and apparatus for extracting carbon dioxide from air: A method and apparatus for extracting CO2 from air comprising an anion exchange material formed in a matrix exposed to a flow of the air, and for delivering that extracted CO2 to controlled environments. The present invention contemplates the extraction of CO2 from air using conventional extraction methods or by... Agent:

20110081713 - System and apparatus for feeding, solubilizing, growing and discharging a biological material: Apparatus useful for feeding a particulate starter material comprising nutrient and bacteria to a mixing tank, for solubilizing the starter material inside the mixing tank, for promoting growth of the bacteria and for discharging an aqueous slurry comprising the bacteria from the mixing tank. The apparatus preferably has a gravity-flow... Agent:

20110081714 - Single layer plastic test sample culture bottle: A bottle for culturing a test sample, e.g., blood, includes a plastic vessel made from a single layer of plastic material. The bottle features a gas barrier. In one embodiment the gas barrier is in the form of a plastic shrink-wrap partially or alternatively completely enveloping the plastic vessel. Other... Agent: Biomerieux Inc.

20110081715 - Single layer plastic test sample culture bottle: A bottle for culturing a test sample, e.g., blood, includes a plastic vessel made from a single layer of plastic material. The bottle features a glass barrier coating applied to the bottle, such as a silica or glass coating. An alternative embodiment features a single layer plastic bottle and a... Agent: Biomerieux Inc.

20110081716 - Automated seed sampler and methods of sampling, testing and bulking seeds: A seed sampler system generally includes an automated sampling station configured to orient a seed and remove a tissue sample from the oriented seed. The seed sampler system may include a support configured to orient a seed received by the support, and an automated sampling mechanism configured to remove a... Agent: Monsanto Technology LLC

20110081717 - Double-stranded nucleic acid molecule, cancer cell proliferation inhibitor and pharmaceutical agent suitable for prevention or treatment of cancer: A double-stranded nucleic acid molecule including (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of SEQ ID Nos.: 1 to 21, and (b) an antisense strand which includes a nucleotide sequence complementary to that of the sense strand specified in... Agent: Rnai Co., Ltd.

20110081718 - System for packaging high-capacity adenoviruses: The invention relates to a nuew system for production and packaging of high capacity adenoviral vectors which does not require the use of helper virues and which is characterized in that it integrates the adenoviral genes needed for the control, replication and packaging of the viral particuiles in the genome... Agent: Proyecto De Biomedicina Cima, S.l.

20110081720 - Method of differentiating stem cells into cells of the endoderm and pancreatic lineage: Methods are described to more efficiently produce cells of the endoderm and pancreatic lineage from mammalian pluripotent stem cells. These methods provide a simple, reproducible culture protocol using defined media components to enable consistent, large-scale production of pancreatic cell types for research or therapeutic uses.... Agent:

20110081719 - Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same: Methods for producing substantially pure cultures of human neural retinal progenitor cells, forebrain progenitor cells, and retinal pigment epithelial cells are disclosed. In addition, the successful differentiation of human embryonic stem cells and human induced pluripotent stem cells through the major developmental stages of human retinogenesis is disclosed.... Agent: Wisconsin Alumni Research Foundation

20110081721 - Process for producing a tissue transplant construct for reconstructing a human or animal organ: A process for producing a tissue transplant construct for reconstructing a human or animal organ. The process may include the steps of: (a) isolation and two-dimensional cultivation of organ-specific tissue cells; (b) application of the organ-specific tissue cells to a biocompatible, collagen-containing membrane; and, (c) cultivation of the organ-specific tissue... Agent: Urotec Gmbh

20110081722 - Animal protein-free media for cultivation of cells: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating... Agent: Baxter Healthcare S.a.

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