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Chemistry: molecular biology and microbiology March listing by industry category 03/11

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
03/31/2011 > 109 patent applications in 63 patent subcategories. listing by industry category

20110076665 - Electromagnetic controlled biofabrication for manufacturing of mimetic biocompatible materials: The precise application of an electromagnetic field controls cell motion to guide extrusion and deposition of biopolymers produced by the cells. This controlled biofabrication process is used to fabricate two- and three-dimensional networks of biocompatible nanofibrils (such as cellulose) for use as biomaterials, tissue scaffolds to be used in regenerative... Agent:

20110076666 - Organ preservation system: An organ preservation system having an organ chamber with a perfusate reservoir surrounded by a heat exchanger. The system has a pump for circulating perfusate, which draws perfusate from the reservoir and passes the perfusate through a bubble trap, and temperature and pressure sensors prior to entering the chamber where... Agent:

20110076668 - Blood sample processing apparatus and blood sample processing method: A blood sample processing apparatus including: a container holder securing a sample container that contains a blood sample, the sample container having a lid, the container holder coupled to a rotation driver that longitudinally rotates the sample container; and a controller that commands the rotation driver to repeatedly perform an... Agent:

20110076669 - Methods and compositions for preserving platelets: The present invention relates to methods for preserving platelet. In one embodiment, the method includes the steps of mixing platelets with a platelet preservation composition to form a platelet preparation, storing the platelet preparation for a desired period of time, and removing the antiplatelet agent and the anticoagulant from the... Agent: Biovec Transfusion, LLC

20110076667 - Methods for improving fertility and selectivity for desired offspring sex in artificial insemination: A method for providing semen optimized for use in artificial insemination is described. Methods involve monitoring sperm cell metabolism by assays that produce results in real time, while sperm are still being processed into doses for use in insemination. Processing is modified in response to assay results, to optimize sperm... Agent:

20110076670 - Detection of analytes via nanoparticle-labeled substances with electromagnetic read-write heads: A first set of antibodies are bonded to a substrate, and are exposed to and bonded with target antigens. A second set of antibodies are bonded to nanoparticles, and the nanoparticle labeled antibodies are exposed to the targeted antigens. An electromagnetic write-head magnetizes the nanoparticles, and then a read-sensor detects... Agent: International Business Machines Corporation

20110076672 - Phage-mediated bioluminescent detection of yersinia pestis: The present disclosure relates to compositions, methods, systems and kits for the detection of microorganisms of the Yersinia species including Yersinia pestis. The disclosure relates to recombinant phage operable to infect a Yersinia microorganism, the phage comprising a detectable reporter. Detection systems of the disclosure may comprise a phage operable... Agent:

20110076671 - Use of synthetic peptide derived from zebra protein for the in vitro diagnosis of the epstein-barr virus (ebv) reactivation: Method of using polypeptide derived from ZEBRA protein, or variants or isoforms of the polypeptide for the in vitro and ex vivo screening of the EBV virus reactivation in a biological sample of a subject afflicted by a pathology associated with EBV infection.... Agent: Universite Joseph Fourier

20110076679 - 3'-o-fluorescently modified nucleotides and uses thereof: The present invention relates to a DNA sequencing method using a nucleoside triphosphate with a fluorescent blocking group on its 3′-OH end as a reversible terminator. Further, the present invention relates to sequencing-by-synthesis method using the mono-modified reversible terminator (MRT), the novel nucleotide monomer having a reversible fluorescent blocking group... Agent: Korea Institute Of Science And Technology

20110076684 - Apparatus and method for acquiring, detecting, and analyzing cells in a microfluidic system: An apparatus is disclosed for acquiring, detecting, and, optionally, analyzing cells in a biological liquid, which apparatus has a microfluidic system. In at least one embodiment, the apparatus includes at least one microfluidic channel having a small cross-section which is completely or partially coated with cell-specific binding molecules and which... Agent:

20110076673 - Detection of bacteria: The invention relates to a method for detecting bacterial contaminations preferably in physiological samples as well as sequences of synthetic oligonucleotides used therefor. The method comprises the steps of i) extracting the nucleic acid, particularly bacterial DNA, ii) amplification by means of primers and detection by means of oligonucleotides, particularly... Agent: Osterreichisches Rotes Kreuz Landesverband Oberosterreich

20110076687 - Fluorescence standard, and the use thereof: The invention concerns fluorescence standards, and in particular fluorescence standards for calibrating optical detectors. According to the invention, a fluorescent mineral or mixtures of minerals are employed for use as a fluorescence standard. The fluorescent mineral can be a naturally occurring mineral or a synthetically produced mineral. Preferred fluorescent minerals... Agent: Qiagen Lake Constance Gmbh

20110076680 - Fluorescent molecule: It is an object of the present invention to provide an on-off type fluorescent compound (a fluorescence-producing molecule system) used in gene analyses, which is highly stable (namely, being active for a long period of time) and highly sensitive, and which enables amplification of a trace amount of gene signal... Agent: Riken

20110076683 - Identification, isolation and elimination of cancer stem cells: Isolated populations of leukemic stem cells are provided. The cells are useful for experimental evaluation, and as a source of lineage and cell specific products, and as targets for the discovery of factors or molecules that can affect them. Detection of leukemic stem cells is useful in predicting disease progression,... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20110076677 - Method for detecting single nucleotide polymorphisms: A method of detecting a single nucleotide polymorphism includes providing a first template polynucleotide, a second polynucleotide comprising a first and second sequence (complementary to a first portion of the first polynucleotide), and a third polynucleotide (complementary to a second portion of the first polynucleotide). The first, second and third... Agent:

20110076688 - Method for enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates: A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a second fluorescent labeled antibody having binding specificity for a surface marker for platelets, and a nucleic... Agent: Litron Laboratories, Ltd.

20110076685 - Method for in vitro detection and differentiation of pathophysiological conditions: The present invention relates to the use of defined polynucleotides to form at least one multi-gene biomarker for producing a multiplex assay as a tool for in vitro detection and/or early detection and/or differentiation and/or progress monitoring and/or evaluation of pathophysiological conditions of a patient, the pathophysiological condition selected from... Agent: Sirs-lab Gmbh

20110076676 - Method of purifying rna binding protein-rna complexes: The present invention provides methods for purifying RNA molecules interacting with an RNA binding protein (RBP), and the use of such methods to analyze a gene expression profile of a cell. The invention also provides sequences of RNA molecules that mediate binding to an RBP, proteins encoded by the sequences,... Agent: The Rockefeller University

20110076681 - Modified gene-silencing nucleic acid molecules and uses thereof: Methods and means for efficiently downregulating the expression of a target gene of interest in cell from an organism that is an animal, fungus, and protest. The invention provides chimeric nucleic acid molecules for downregulating target genes. The invention also provides modified cells and organisms comprising the chimeric nucleic acid... Agent: Commonwealth Scientific And Industrial Research Organisation

20110076675 - Novel methods for quantification of micrornas and small interfering rnas: The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA... Agent: Exiqon A/s

20110076682 - Over-production of secondary metabolites by over-expression of the vea gene: The invention provides a general and facile method to obtain secondary metabolites from fungal sources. The invention is based on the discovery that the fungal gene veA and protein encoded thereby regulates the activity of multiple secondary metabolite gene clusters in fungi. Over expression of the gene veA provides increased... Agent: Wisconsin Alumni Research Foundation

20110076689 - Primer for detecting tyrosinase mrna: The present invention provides a means and method for detecting TYR mRNA. As a primer for detecting TYP mRNA, a primer comprising a first sequence at the 5′ end side and a second sequence at the 3′ end side, wherein the first sequence has 10 to 30 nucleotides in length,... Agent: Sysmex Corporation

20110076674 - Rapid epidemiologic typing of bacteria: Methods for typing a strain of an organism are provided, the methods comprising the steps of amplifying, in a single reaction mixture containing nucleic acid from the organism, dividing the reaction mixture into a plurality of sets of second-stage reaction wells, each set of second-stage reaction wells containing a different... Agent:

20110076678 - Reprogramming of somatic cells: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to... Agent:

20110076690 - Titer plate, reading device therefor and method for detecting an analyte, and use thereof: A titer plate and a method for detecting an analyte, and the use thereof are disclosed. According to at least one embodiment of the invention, it is proposed that a plurality of depressions and a biochip of the titer plate sposed adjacent thereto be surrounded by a wall in order... Agent: Siemens Aktiengesellschaft

20110076686 - Water management: A method for detecting and enumerating viable microorganisms in a sample suspected of containing said microorganisms comprising: (1) contacting said sample with a cell nutritive resource and a cellular proliferation inhibitor, (2) contacting said sample with at least one fluorescence labelled oligonucleotidic probe able to specifically hybridise at least one... Agent: Basf Se

20110076691 - Two step lateral flow assay methods and devices: A two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions... Agent:

20110076696 - Cardiovascular safety assay: The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity of compounds during... Agent: Janssen Pharmaceutica, N.v.

20110076698 - method of quickly determining human abo/rh/mn blood type and a test kit thereof: A method of quickly determining human ABO/Rh/MN blood type and a test kit thereof. A blood sample to be detected is applied onto a test strip pre-coated with anti-A or anti-B or anti-M or anti-N antibody, a rinse solution is dripped onto one end of the test strip, and then... Agent: Intec Products, Inc. (xiamen)

20110076697 - Lateral-flow immuno-chromatographic assay devices: Device including migration membrane, conjugate pad on migration membrane, plasma separation membrane on conjugate pad, pre-filter on plasma separation membrane. Migration membrane has test line configured for loading one or plurality of capture antibodies having specific binding affinity for assay target. Migration membrane configured for allowing lateral flow of blood... Agent: Innovative Laboratory Technologies, Inc.

20110076699 - Hemolysin and its protein fragments in sero-detection of anaplasma phagocytophilum: Disclosed is the cloning, expression and purification of a hemolysin protein and its protein fragments in Anaplasma phagocytophilum. The recombinant hemolysin and its protein fragments are useful in the ELISA detection of anaplasma pathogen. The use of same as a kit for ELISA is also disclosed.... Agent: Medical Diagnostic Laboratories, LLC

20110076692 - Detection of cardiac markers on a droplet actuator: The present invention provides for the detection of cardiac markers on a droplet actuator. An aspect provides a method of assaying a cardiac marker in a biological sample from a subject, the method including providing a droplet actuator, loading the biological sample and assay reagents on the droplet actuator, executing... Agent:

20110076693 - Method for detection and quantification of plk1 expression and activity: Isolated peptide substrates of Plk1 and nucleic acids encoding these peptides are disclosed. The peptides include two to ten repeats of the amino acid sequence set forth as X1X2AX3X4X5PLHSTX6X7X8X9X10X11X12 (SEQ ID NO: 1), in which within each repeat X1, X2, X6, X7, X8, X9, X10, X11, and X12 are each... Agent: The U.s.a. As Represented By The Secretary , Dept.of Health And Human Services (the Gov.)

20110076695 - Immunoassay analyzer and immunoassay method: The present invention provides an immunoassay analyzer capable of discriminating between normal coloring due to a specific immunoreaction and abnormal coloring due to a cause other than the specific immunoreaction in a measurement region of a sample analysis tool. An immunoassay analyzer 1 of the present invention includes an optical... Agent: Arkray, Inc.

20110076694 - Method of assessing mammalian embryo quality: A method of assessing the health of each oocyte or embryo of a mammal from a plurality of oocytes/embryos of the mammal is provided. The method comprises the steps of: measuring gap junctional coupling strength or connexin43 expression of follicular cells associated with each oocyte; and identifying the gap junctional... Agent:

20110076700 - Anti-crp antibody and utilization of the same: It is intended to provide means capable of specifically recognizing CRP in a test sample and assaying it with high sensitivity. The present invention provides an anti-CRP antibody which reacts with a C-reactive protein (hereinafter referred to as CRP) and recognizes an epitope located at residues 147 to 172 in... Agent: Nihon University

20110076701 - Multi-stage nutrigenomic diagnostic food sensitivity testing in animals: A multi-stage method for diagnosing an immunologic food sensitivity or intolerance in a companion animal. Firstly a saliva or blood spot or other non-serum bodily fluid sample is collected. The screening the saliva or blood spot or other non-serum bodily fluid sample detects the presence of at least one of... Agent:

20110076703 - Concentration assay: A method of determining the concentration of at least one analyte in a plurality of samples by sequentially subjecting each sample to an analysis cycle comprises contacting the sample or a sample-derived solution with a sensor surface supporting a species capable of specifically binding the analyte or an analyte-binding species,... Agent: Ge Healthcare Bio-sciences Ab

20110076702 - Recombinant 12-kda protein useful for the detection of respiratory allergies: The present invention discloses the detection of an important 12K-Da protein having cross-reactivity amongst different prevalent allergenic grasses and fungi can be useful for detection of respiratory allergies. Conventionally, the whole extracts that are used for diagnosis are unable to specifically detect the causative agents. In addition, they are also... Agent: Council Of Scientific And Industrial Research

20110076705 - Compositions and methods for early pregnancy diagnosis: Disclosed are antibodies and methods for detecting pregnancy in an animal. In certain aspects antibodies used binds immunologically to at least two PAGs selected from PAG4, PAG6, PAG9, PAG16, PAG17, PAG19, PAG20 and PAG21. Antibody encoding nucleic acids are also provided, as are kits, methods of use and additional antibody... Agent: The Curators Of The University Of Missouri

20110076704 - Method for diagnosing alzheimer's disease using serum glycoprotein as biomarker: It is an object of the present invention to detect a change in the metabolism of a glycoprotein having an α2,6-sialyl residue, which is contained in blood, so as to provide an agent and a method for diagnosing sporadic Alzheimer's disease. The present invention provides an agent for diagnosing Alzheimer's... Agent: Riken

20110076706 - Methods and kits for the rapid detection of microorganisms: The present invention provides analytical methods and related kits for detecting the presence of bacteria in a sample, determining the amount of bacteria in a sample, or determining the type of bacteria in a sample. In particular, the invention relates to devices and methods suitable for the rapid detection, quantification,... Agent: Genprime, Inc.

20110076707 - Mutant glucose dehydrogenase: Substrate specificity for glucose of a glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 13 is improved by substituting another amino acid residue for the amino acid residue at position 472 and/or 475.... Agent: Arkray, Inc.

20110076708 - Cartilage intermediate layer protein 2 c1 and its use to differentiate osteoarthritis from rheumatoid arthritis and non-disease conditions: A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of human cartilage intermediate layer protein 2 (CILP-2) in body fluids and more specifically, measuring in the sample the concentration of the N-terminal part of CILP-2 (2C1) or... Agent:

20110076709 - Method for the diagnosis of leukemia using caspase-3: The invention provides methods for determining the prognosis of a patient diagnosed with a leukemia, including B-cell chronic lymphocytic leukemia and acute myelogenous leukemia, by measuring the level of caspase-3 activity in a biological sample. The invention also relates to the diagnosis of leukemia, including B-cell chronic lymphocytic leukemia and... Agent: Quest Diagnostics Investments Incorporated

20110076712 - Lubricious microfludic flow path system: A flow cytometer having a nozzle assembly which provides a lubricious flow path through which a plurality of particles pass to be entrained in a flow of liquid to provide a faster method for sorting with increased cell quality.... Agent: Xy, LLC.

20110076710 - Method for characterising a biologically active biochemical element by analasing low frequency electromagnetic signals: The invention relates to a method for characterising a biologically active biochemical element by analysing low-frequency electromagnetic signals transmitted by a solution prepared from an analysable material sample characterised in that it comprises a pre-filtering stage.... Agent:

20110076711 - Photon reducing agents for fluorescence assays: The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method for reducing undesirable light emission from a sample (e.g., a... Agent: Life Technologies Corporation

20110076713 - Process of characterization of hepatocytes from goat: A process for characterization of hepatocytes cells in goat comprising isolating goat hepatocytes and characterizing the isolated hepatocytes by biochemical and molecular techniques to demonstrate the hepatic functions.... Agent:

20110076716 - Bacteria analysis apparatus, bacteria analysis method and computer program product: A bacteria analysis apparatus comprising: a specimen preparation section for preparing a first measurement specimen from a sample by using a first enzyme; a detecting section for detecting bacteria included in the first measurement specimen; and an information processing section for outputting information for supporting determination of kind of bacteria... Agent: Sysmex Corporation

20110076714 - Method for the presence detection of microorganisms in a bioreactor, bioreactor and arrangement: The invention relates to a method for the presence detection of microorganisms in a bioreactor (B), to a bioreactor (B), and to an arrangement for performing the detection method. In order to reduce the staffing expense during the detection analysis of the presence of undesirable microorganisms in a bioreactor (B)... Agent: Siemens Ag

20110076715 - Method of singulating embryos: A method of singulating embryos is provided. The method includes providing a plurality of embryos (40) within a system (20) and sensing (34) at least one of the plurality of embryos in a fluid. The method also includes dispensing (26) at least one of the plurality of embryos on a... Agent: Weyerhaeuser Nr Company

20110076717 - Culture medium containing a spore germination inhibiting or delaying compound: A medium for the culture and detection of target microorganisms, having at least one natural or synthetic specific substrate configured to detect at least one enzyme activity or metabolic activity of the target microorganisms and at least one compound that inhibits or delays the germination of spores of microorganisms, other... Agent: Biomerieux

20110076718 - In vivo incorporation of an unnatural amino acid comprising a 1,2-aminothiol group: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids that comprise a 1,2 aminothiol group into polypeptides. The invention provides translation systems in which polypeptides comprising unnatural amino acids that comprise a 1,2 aminothiol group can be produced. The invention also provides... Agent: The Scripps Research Institute

20110076719 - Substantially animal protein-free recombinant furin and methods for producing the same: The present invention relates to recombinant furin (rFurin) and methods for producing rFurin. More specifically, the invention relates to substantially animal protein-free rFurin and methods for producing substantially animal protein-free rFurin.... Agent: Baxter Healthcare S.a.

20110076721 - Efficient production of heterologous proteins using mannosyl transferase inhibitors: Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidine-diones inhibitors of Pmt-mediated O-linked glycosylation.... Agent: Merck Sharp & Dohme Corp.

20110076720 - Nicking endonuclease methods and compositions: A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or gutamic acid corresponding to position 507 and position 546 respectively in SEQ ID NO:6.... Agent: New England Biolabs, Inc.

20110076723 - Antibody-peptide fused synergibody: Disclosed herein are synergibodies, antibody-peptide fused protein molecules containing antibodies and bioactive peptides, which function in the occurrence or progress of the identical disease.... Agent: Samsung Electronics Co., Ltd.

20110076722 - Stable multivalent antibody: The present invention relates to a multivalent antibody comprising multiple heavy chain variable regions of antibody linked to each other via a linker comprising an amino acid sequence encoding an immunoglobulin domain or a fragment thereof.... Agent: Kyowa Hakko Kirin Co., Ltd.

20110076725 - Lignin blockers and uses thereof: Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment enhances cellulase availability in cellulose conversion and allows for the determination of optimized pretreatment conditions. Additionally, ethanol yields from a Simultaneous Saccharification and... Agent: The Trustees Of Dartmouth College

20110076724 - Process, plant, and biofuel for integrated biofuel production: This invention relates to a process, a plant, and a biofuel for integrated biofuel production, such as with butanol, biodiesel, and/or sugar product. The integrated process includes the step of removing hexose from a feedstock to form a lignocellulosic material. The process also includes the step of converting the hexose... Agent: Bp Biofuels Uk Limited

20110076726 - Differential enzymatic fragmentation by whole genome amplification: The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.... Agent: Orion Genomics LLC

20110076727 - Penetrable cap: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip... Agent: Gen-probe Incorporated

20110076728 - Target amplification and sequencing with primers comprising triplex forming monomer units: The current inventors have discovered that the incorporation of a triplex forming monomer unit into oligonucleotides surprisingly gives the oligonucleotide a number of favorable characteristics. The oligonucleotides are advantageous because they allow modulation of the melting temperature of an oligonucleotide, they have improved sequence specificity and they can form triplexes... Agent: Quantibact A/s

20110076729 - Methods of making low molecular weight heparin compositions: Methods of making LMWH compositions are provided to provide the LMWH compositions at a yield of at least about 10%.... Agent: Momenta Pharmaceuticals, Inc.

20110076730 - Microbial synthesis of d-1,2,4-butanetriol: Improved enzyme systems, recombinant cells, and processes employing the same to produce biosynthetic D-1,2,4-butanetriol; D-1,2,4-butanetriol prepared thereby and derivatives thereof; D-1,2,4-butanetriol trinitrate prepared therefrom; and enzymes and genes useful in the enzyme systems and recombinant cells.... Agent: Board Of Trustees Of Michigan State University

20110076731 - promoter, and a production method for l-lysine using the same: Disclosed are a nucleic acid molecule of Corynebacterium glutamicum origin, having an improved promoter activity, which is operably linked to a gene encoding diaminopimelate dehydrogenase, a vector containing the same, a transformant transformed with the vector, and a method for the production of L-lysine using the transformant.... Agent: Cj Cheiljedang Corporation

20110076733 - Cytosolic isobutanol pathway localization for the production of isobutanol: The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects... Agent: Gevo, Inc.

20110076732 - Process, plant, and butanol from lignocellulosic feedstock: This invention relates to a process, a plant, and butanol made of or derived from lignocellulosic feedstock. The process includes the step of depolymerizing lignocellulosic material to form pentose and a remainder. The process also includes the step of converting the pentose to butanol material and using the remainder for... Agent: Bp Biofuels Uk Limited

20110076734 - Electrowetting microarray printing system and methods for bioactive tissue construct manufacturing: Apparatuses and methods for manufacturing three-dimensional, bioactive, tissue scaffold fabrications with embedded cells and bioactive materials, such as growth factors, using biomimetic structure modeling, solid freeform fabrication, biocompatible hydrogel material, and electrowetting on dielectric-based multi-microarray printing.... Agent: Duke University

20110076735 - Microfluidic devices: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.... Agent:

20110076736 - Fuel cell, method for manufacturing fuel cell, electronic apparatus, enzyme immobilization electrode, biosensor, bioreactor, energy conversion element, and enzyme reaction-utilizing apparatus: A fuel cell and a method for manufacturing the same are provided, wherein at least one type of enzyme and coenzyme are confined in a minute space, an enzyme reaction is effected while this space serves as a reaction field. Thereby, electrons can be taken out of the fuel efficiently... Agent: Sony Corporation

20110076737 - Carriers for immobilization and reusability of enzymes: This patent involves improvement of the thermal stability of natural polymers, “hydrogels”, to be used as supports for covalent immobilization of enzymes. The presence of the new functionality has been proved by FTIR. In brief, the new polymeric carrier has the main following advantages: • Natural polymer & friendly to... Agent:

20110076738 - Solvent-borne polymeric bioactive coatings for the facilitated removal of bioorganic stains: Protein-polymer composite materials are provided according to embodiments of the present invention that include an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition.... Agent: Toyota Motor Corporation

20110076739 - Catalytic domains from lysyl oxidase and loxl2: Disclosed herein are amino acid sequences, and encoding nucleotide sequences, of isolated catalytic domains of the LOX and LOXL2 proteins from human and mouse. Methods for the preparation and use of these isolated catalytic domains are also provided.... Agent:

20110076740 - Amylases, nucleic acids encoding them and methods for making and using them: In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as amylases to catalyze the hydrolysis of starch into sugars.... Agent: Verenium Corporation

20110076741 - Alpha-amylase variants: The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase.... Agent: Novozymes A/s

20110076742 - Polynucleotides encoding novel pcsk9 variants: The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the... Agent: Bristol-myers Squibb Company

20110076743 - Three-dimensional structure of isoprene synthase and its use thereof for generating variants: The present invention provides a three-dimensional structures of P. tremuloides isoprene synthase and P. alba isoprene synthase. The invention also provides methods of using the three-dimensional structure to design isoprene synthases with improved activity for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds... Agent:

20110076744 - Compositions and methods to prevent aav vector aggregation: Compositions and methods are provided for preparation of concentrated stock solutions of AAV virions without aggregation. Formulations for AAV preparation and storage are high ionic strength solutions (e.g. μ˜500 mM) that are nonetheless isotonic with the intended target tissue. This combination of high ionic strength and modest osmolarity is achieved... Agent:

20110076745 - Method and agent for controlling plant disease using bacteria of genus bacillus: This invention provides a control agent or material for biologically controlling plant diseases caused by plant pathogenic bacteria, fungi, or viruses, a method for controlling plant diseases using the same, and bacteria that can be used therefor. Also, this invention relates to a control agent or material for plant diseases... Agent:

20110076746 - Medium and method for culturing mycobacterium avium subspecies paratuberculosis: The present invention provides a growth medium and kit containing a nicotine analog and use of the same in a method for enhancing the growth of Mycobacterium avium subspecies paratuberculosis (MAP).... Agent:

20110076747 - Algae producing trough system: A trough lining assembly is placed in a series of troughs at a biomass processing facility. The trough lining assembly includes a waterproof liner that lies against the sides of a trough, an aerator, a nutrient line, and a retention mechanism that retains the aerator and nutrient line at the... Agent:

20110076748 - Method and apparatus using an active ionic liquid for algae biofuel harvest and extraction: The invention relates to use of an active ionic liquid to dissolve algae cell walls. The ionic liquid is used to, in an energy efficient manner, dissolve and/or lyse an algae cell walls, which releases algae constituents used in the creation of energy, fuel, and/or cosmetic components. The ionic liquids... Agent: Streamline Automation, LLC.

20110076749 - Microalgae with high-efficient ability to remove carbon dioxide and use thereof: The present invention relates to microalgae having high efficiency and ability to remove carbon dioxide, and the use thereof. More specifically, the invention relates to Scenedesmus producto-capitatus microalgae having high carbon dioxide fixation rate and the use thereof. The microalgae of the invention have a high carbon dioxide fixation rate... Agent:

20110076750 - Process for the treatment of liquid effluents laden with hydrocarbons: The present invention relates to a process for the treatment of liquid effluents laden with hydrocarbons, which comprises: feeding the effluents into a treatment tank; supplying the treatment tank with a reversible sorbent having a defined particle size; mixing the effluents with the reversible sorbent in the treatment tank in... Agent: Novad Sas

20110076751 - Lysis, binding and/or wash reagent for isolating and/or purifying nucleic acids: The present invention relates to a lysis, binding and/or wash reagent for isolating and/or purifying nucleic acids and a method for isolating and/or purifying nucleic acids.... Agent: Qiagen Gmbh

20110076752 - Antibody library display by yeast cell plasma membrane: The present invention relates to antibodies or antibody fragments that may be displayed on the extracellular surface of the plasma membrane when expressed in a host cell. The present invention provides libraries comprising a plurality of plasma membrane displayed antibodies and methods of screening the libraries for antibodies or antibody... Agent: Medimmune, LLC

20110076753 - Apparatus for embedding tissue samples: A histology tissue embedding apparatus including a reservoir for an embedding medium and an outlet valve connected to the reservoir through which the embedding medium is dispensable, and including trigger means which control the operation of the outlet valve, the trigger means having a rest position in which the outlet... Agent:

20110076754 - Device and method for filtering one or more particles to be detected from a fluid: A device is disclosed for filtering a particle to be detected from a fluid. In at least one embodiment, the device includes a substrate and, applied above it, a protective layer, a channel being disposed between them for the purpose of receiving a fluid containing different particles. In at least... Agent: Siemens Aktiengesellschaft

20110076755 - Sample preparation apparatus and cell analyzer: A sample preparation apparatus comprising: a storage chamber that can store therein a liquid sample including an analysis target to be analyzed; a concentrated sample storage chamber that is provided to communicate with the storage chamber and that stores therein concentrated liquid having an analysis target having a higher concentration... Agent: Sysmex Corporation

20110076756 - variable volume bioreactor: A variable volume bioreactor including a rigid core associated with a light source, an outer expandable growth containment portion located concentrically about the rigid core, a lower end portion associated with an inlet to supply culture medium and an outlet, and an upper end cap with an opening therein through... Agent:

20110076757 - Automated algae culture apparatus: An automated algae culture apparatus includes at least one photosynthetic reactor module and an auxiliary equipment module. The photosynthetic reactor module includes a transparent container used to contain an algae solution which includes algae. The auxiliary equipment module includes a hydraulic filter, a buffer tank and an aerator. The hydraulic... Agent: Byotec Biotechnology Co. Ltd

20110076758 - Apparatus for high-throughput cell culture with mechanical compression stimulation: An apparatus for high-throughput cell culture with mechanical compression stimulation includes a cell culture vessel and a fluid pressure supply unit. The cell culture vessel includes at least one culture chamber, at least one pressure chamber disposed above the culture chamber, a membrane disposed between the culture chamber and the... Agent: Chang Gung University

20110076759 - Bioreactor with condenser: Bioreactor with a vessel having at least one gas dissipation duct for gas discharge, the orifice of the gas dissipation duct being connected to a hydrophobic sterile filter and to a condenser arranged between them and having condensation surfaces, a turbulence generator for generating a turbulent flow is arranged in... Agent: Sartorius Stedim Biotech Gmbh

20110076762 - Articles formed by manufacturing processes, such as three-dimensional printing, including solvent vapor filming and the like: Methods of manufacturing an article use three-dimensional printing for a portion of the manufacturing. Three-dimensionally printing is conducted onto a powder bed which contains both organic-solvent-soluble, water-insoluble particles and water soluble, organic-solvent-insoluble particles. The water-soluble particles which may be selected for properties such as size and may include more than... Agent: Massachusetts Institute Of Technology

20110076761 - Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers: The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids.... Agent: Neogenix Oncology, Inc.

20110076760 - Viral expression plasmids for production of proteins, antibodies, enzymes, virus-like particles and for use in cell-based assays: This disclosure shows that the EBV FR-element comprised of EBNA1 multimeric binding sites can provide the stable maintenance replication function to the mouse polyomavirus (PyV) core origin plasmids in the presence of BPV-1 E2 protein and PyV large T-antigen (LT).... Agent: Icosagen S.a.

20110076763 - Neoplasm specific antibodies and uses thereof: The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.... Agent: Patrys Limited

20110076764 - Methods and kits for cell release: Methods and kits of releasing cells are provided. The method comprises the steps of providing cultured cells on a cell culture support comprising a multi layer polyelectrolyte coating immobilized on a substrate, and releasing the cultured cells from the cell culture support by a releasing solution comprising DMSO. The kit... Agent: General Electric Company

20110076766 - Cytostatic drug composition: A drug composition containing as a drug substance a polymeric guanidine derivative based on a diamine containing oxyalkylene chains between two amino groups, with the guanidine derivative representing a product of polycondensation between a guanidine acid addition salt and a diamine containing polyalkylene chains between two amino groups, as well... Agent:

20110076767 - Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex: A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of... Agent: The Children's Hospital Of Philadelphia

20110076768 - Method for detecting carcinoma and agent for suppressing carcinoma: An object of the present invention is to identify genes exhibiting characteristic behavior in the cases of carcinoma such as oral squamous-cell carcinoma using a change of expression level of micro RNA in oral squamous-cell carcinoma as an indicator, so as to provide a method for detecting carcinoma and an... Agent:

20110076765 - Method for increasing the activity of lysosomal enzymes: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl... Agent: Mount Sinai School Of Medicine Of New York University

20110076769 - Mammary artery derived cells and methods of use in tissue repair and regeneration: An isolated mammalian internal mammary artery-derived cell is disclosed. Furthermore, methods of isolating the mammalian internal mammary artery-derived cell are disclosed. The cell is useful in tissue engineering technologies, specifically in vascular tissue engineering.... Agent: Advanced Technologies And Regenerative Medicine, LLC

20110076770 - Culturing method of mesenchymal stem cell: To efficiently select and proliferate the mesenchymal stem cells without necessity of an exclusive separating device and a complicated separating operation, mesenchymal stem cells are cultured by seeding at least one of a bone marrow solution, an umbilical cord blood, a peripheral blood, a synovial membrane and an amniotic membrane... Agent: Two Cells Co., Ltd.

20110076771 - Tissue fiber scaffold and method for making: The present disclosure relates to a fiber, a method of forming a fiber, a system for forming a fiber, and a method of engineering tissue from a fiber. The fiber includes an engineered geometric feature forming a non-Euclidian geometry.... Agent: Hills Inc.

20110076772 - Methods of preparing nutritive media for growth and/or germination of plant embryos: In one aspect, a method is provided for producing an improved nutritive medium comprising an adsorbent material for culturing plant embryos.... Agent: Weyerhaeuser Nr Company

20110076773 - Delivery of dna or rna via gap junctions from host cells to target cells and a cell-based delivery system for antisense or sirna: A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the... Agent: Columbia University In The City Of New York

  
03/24/2011 > 78 patent applications in 49 patent subcategories. listing by industry category

20110070574 - Method for virus detection: A method of determining the concentration of a virus or antigen thereof in a sample comprises the steps of: providing a sensor surface having immobilized thereto a virus antigen or a virus antigen analogue, mixing the sample with a known amount of antibody to the virus antigen to obtain a... Agent:

20110070578 - Dna analyzer: Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second... Agent: Lockheed Martin Corporation

20110070582 - Gene expression profiling for predicting the response to immunotherapy and/or the survivability of melanoma subjects: A method is provided in various embodiments for determining a profile data set for predicting the response top immunotherapy and or survivability of a subject with melanoma based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification under measurement conditions... Agent: Source Precision Medicine, Inc. D/b/d Source Mdx

20110070575 - Immunomodulatory compositions, combinations and methods: The invention provides immunomodulatory compositions, immunomodulatory combinations, and methods of modulating TLR7-mediated biological activity. Generally, the immunomodulatory compositions include an immunomodulatory oligonucleotide in an amount effective to reduce TLR7-mediated biological activity. In some cases, an immunomodulatory combination can further include an IRM compound. In some of these embodiments, the IRM... Agent: Coley Pharmaceutical Group, Inc.

20110070585 - Integrated nucleic acid analysis: The present invention relates to an integrated method of nucleic acid analysis, and more particularly to a simplified sample pre-treatment, which renders the method more easily automated, where the sample is provided on or applied onto a solid matrix and the subsequent amplification and detection steps are performed in one... Agent: Wallac Oy

20110070583 - Lsamp gene associated with cardiovascular disease: The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with... Agent: Duke University

20110070589 - Magnetic lysis method and device: A method for lysing cells is disclosed. The method includes stirring cells with a magnetic stir element in the presence of a plurality of cell lysis beads at a speed sufficient to lyse the cells. Also disclosed is a device for lysing cells. The device includes a container having a... Agent:

20110070577 - Method for detecting target nucleic acids using template catalyzed transfer reactions: The present invention relates to the detection and quantification of nucleic acid sequences and to the sequence determination of nucleic acids using template catalyzed transfer reactions. The invention also relates to methods, reagents, and kits for detecting and quantifying nucleic acid sequences and for determining the sequence of nucleic acids.... Agent: Humboldt-universit&#xc4 T Zu Berlin

20110070584 - Methods and compositions for diagnosing and monitoring autoimmune and chronic inflammatory diseases: Methods of diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis... Agent: Xdx, Inc.

20110070588 - Methods for identifying genomic deletions: The genomic locus responsible for Van Buchem's disease is narrowed to an approximately 92 kb region of human chromosome 17 at 17q21. Individuals afflicted with or carriers of Van Buchem's disease exhibit a 52 kb deletion within this 92 kb region. Methods are provided that permit the differentiation between individuals... Agent: Celltech R&d Inc.

20110070580 - Methods, compositions, and kits for amplifying and sequencing polynucleotides: In one aspect, there are provided methods of amplifying and sequencing a polynucleotide. In some embodiments, the method includes (a) amplifying the polynucleotide with at least one amplification primer, a processive amplification polymerase, a sequencing primer, a sequencing polymerase, deoxynucleoside triphosphates suitable for template-dependent primer extension, and one or more... Agent: Life Technologies Corporation

20110070586 - Multiplex detection of agricultural pathogens: Described are kits and methods useful for detection of agricultural pathogens in a sample. Genomic sequence information from agricultural pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized... Agent: Lawrence Livermore National Security, LLC

20110070579 - Polyketide synthase-nonribosomal peptide synthetase gene: The objective is to provide a method for rapidly, and highly accurately performing genetic detection of the cyclopiazonic acid-producing ability in a strain belonging to genus Aspergillus, etc. as well as a transformant (strain), etc. that does not produce cyclopiazonic acid or a precursor thereof, cycloacetoacetyl L-tryptophan (CAT). A polynucleotide... Agent:

20110070590 - Primers and methods for determining rhd zygosity: Provided herein are primers comprising a nucleotide sequence complementary to a portion of a RhD gene. Also provided herein are methods of determining a RhD zygosity in a subject. Also provided are methods of detecting a weak D allele in a subject. Further provided are kits for determining an RhD... Agent:

20110070591 - Replication protein: This invention relates to a screening method for the identification of agents which modulate the activity of a DNA replication protein as a target for intervention in cancer therapy and includes agents which modulate said activity. The invention also relates to the use of the DNA replication protein, and its... Agent: Cizzle Biotechnology Limited

20110070581 - Separation of leukocytes: Leukocytes (e.g., neutrophils, monocytes and/or lymphocytes) can be captured and separated from blood by removing platelets using a spiral channel, followed by capturing individual leukocyte types in a series of cell capture channels having leukocyte binding moieties. Accordingly, various microfluidic-based cell affinity chromatography methods can be used to separate leukocytes... Agent:

20110070587 - System for genetic surveillance and analysis: A genetic surveillance system comprises a communications network and at least one reader-analyzer instrument. The reader-analyzer instrument has a communication interface to communicate over the network. The reader-analyzer instrument is adapted to perform genetic assay analysis of a sample obtained from a member of a population and to generate detection-related... Agent: Life Technologies Corporation

20110070576 - Vitro diagnostic kit for identification of human papillomavirus in clinical samples: A method and kit for detection and typing of HPV in a sample are described, as is a reaction vessel for use in the method. Universal HPV primers are used to amplify a sample by PCR; the amplified sample is then hybridised to an array of HPV type-specific probes to... Agent: Genomica S.a.u.

20110070593 - Conjugates of biological substances: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.... Agent:

20110070592 - Detection of antibody that binds to water soluble polymer-modified polypeptides: The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the... Agent: Baxter Healthcare S.a

20110070598 - Detection of elevated levels of her-2/neu protein on circulating cancer cells and treatment: The expression of Her-2/neu protein on circulating cancer cells in a blood sample is detected by isolating the cancer cells from the blood sample and then performing on the isolated cancer cells a sensitive Her-2/neu immunoassay. A positive result indicates the expression of Her-2/neu on cancer cells in the blood... Agent: Wellstat Biologics Corporation

20110070599 - Method for screening of active tuberculosis: The present invention provides an improved and simplified assay for use in diagnosing active Tuberculosis infections. The present assay is carried out using a sample of whole blood, does not require separating the blood into components, such as the isolation of peripheral blood mononucleocytes (PBMC), and is carried out using... Agent: Becton, Dickinson And Company

20110070600 - Particle agglutination in a tip: An apparatus and a related method for performing particle agglutination reactions in at least one disposable probe tip are disclosed. The at least one probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition... Agent: Ortho-clinical Diagnostics, Inc.

20110070594 - Method for detecting escherichia coli: Described herein are methods of detecting an infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an... Agent: Systagenix Wound Management

20110070595 - Methods for the identification of parp interacting molecules and for purification of parp proteins: The present invention relates to immobilization compounds and methods useful for the identification of PARP interacting compounds or for the purification or identification of PARP proteins.... Agent: Cellzome Ag

20110070596 - Agents and methods for analyzing protein interactions: Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit... Agent: General Electric Company

20110070597 - Thin-film passive samplers for detection of hydrophobic organic contaminants and estrogenicity in various environments: A thin-film passive sampler for use in detecting hydrophobic organic contaminants in air or aqueous environments. The sampler features a relatively thin layer of a suitable absorbent matrix coated directly on a solid support unit made of an inert material such as titanium or glass fibers. The passive samplers are... Agent: University Of Connecticut

20110070601 - Classification of individuals suffering from cardiovascular diseases according to survival prognoses as found by measuring the levels of biomarker ykl-40: The present invention relates to the method of measuring the YKL-40 level and using this measurement as a prognosis for survival of an individual suffering from heart disease caused by atherosclerosis. The method may be used for classification of individuals in order to optimize treatment or monitoring the individuals during... Agent: Rigshospitalet

20110070604 - Analysis of ex vivo cells for disease state detection and therapeutic agent selection and monitoring: Described herein is the analysis of nanomechanical characteristics of cells. In particular, changes in certain local nanomechanical characteristics of ex vivo human cells can correlate with presence of a human disease, such as cancer, as well as a particular stage of progression of the disease. Also, for human patients that... Agent: The Regents Of The University Of California

20110070603 - Disc for testing blood, blood tester having the same, and control method thereof: Disclosed are a blood tester for measurement of temperature of a sample placed in a blood-testing disc using a thermochromic pigment, and a control method thereof. The disclosed blood-testing disc, the blood tester having the blood-testing disc loaded therein, and the control method of the same, are used to measure... Agent: Samsung Electronics Co., Ltd.

20110070602 - Methods and apparatuses for measuring biological processes using mid-infrared spectroscopy: This invention relates to methods and apparatuses for measuring biological processes using mid-infrared spectroscopy. The method includes the step of directing a mid-infrared signal into a sample of a biological process during a biologically active phase, and the step of detecting a sample spectrum from the mid-infrared signal to form... Agent: Bp Corporation North America Inc.

20110070605 - Reversible mhc multimer staining for functional purification of antigen-specific t cells: The present invention relates to a new method for reversible staining and functional isolation or characterization of cells, e.g. antigen-specific T cells. With this technique, the original functional status of cells can be substantially maintained after their identification and purification. Thus, this new method is of broad benefit for basic... Agent:

20110070606 - Systems and methods for analyzing body fluids: Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the... Agent: Constitution Medical, Inc.

20110070607 - Glycoprotein synthesis and remodeling by enzymatic transglycosylation: A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of a catalyst comprising endoglycosidase (ENGase), to... Agent:

20110070608 - Method for producing corn gluten hydrolysate and corn gluten hydrolysate using the same: Provided is a method for producing corn gluten hydrolysate comprising: (a) separating corn gluten protein by removing carbohydrate, water soluble sugars, inorganic materials and fiber material; (b) preparing corn gluten protein lysate by carrying out acid hydrolysis, enzymatic hydrolysis or natural fermentation; and (c) increasing a content of branch chain... Agent: Sempio Foods Company

20110070611 - Process for preparing human g-csf: The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.... Agent: Cadila Healthcare Limited

20110070610 - Processing enzymes fused to basic protein tags: The invention is related to processing enzyme comprising an N-terminally attached tag derived from highly basic proteins from thermophilic bacteria. The processing enzymes are useful for modifying proteins. They can be produced in high yields and can be effectively separated from the modified protein after use.... Agent: Novo Nordisk Health Care Ag

20110070609 - Production of foreign nucleic acids and polypeptides in sprout systems: The present invention provides systems and methods for producing a nucleic acid or protein in transgenic sprouted seedlings or sprouted seedlings engineered to transiently express a nucleic acid or protein of interest. The sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically... Agent: Fraunhofer U.s.a., Inc.

20110070612 - Gene inactivated mutants with altered protein production: A recombinant filamentous fungal cell (e.g. Aspergillus) having one or more inactivated chromosomal genes is provided. The chromosomal genes in some embodiments correspond to derA, derB, htmA, mnn9, mnn10, ochA, dpp4, dpp5, pepAa, pepAb, pepAc, pepAd, pepF and combinations thereof. The recombinant fungal cells may include further inactivated chromosomal genes... Agent:

20110070615 - Compositions and methods relating to anti-igf-1 receptor antibodies: The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments and derivatives of such antibodies, and IGF-1R-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding... Agent: Amgen Inc.

20110070614 - Fucose transporter: The present invention provides a gene encoding a fucose transporter, a fucose transporter polypeptide, a method for screening for a compound that binds to a fucose transporter or a compound that inhibits fucose transport activity, a cell having inhibited fucose transporter functions, and a cell wherein the expression of the... Agent:

20110070613 - Monoclonal antibody: The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The... Agent: Ac Immune S.a.

20110070616 - Production of itaconic acid: The invention relates to a nucleic acid sequence encoding an itaconate transporting Major Facilitator Superfamily Transporter (MFST) gene sequence and the protein encoded thereby. Preferably said sequence is the nucleic acid that comprises the sequence of ATEG_09972.1 of Aspergillus terreus or homologues thereof. Overexpression of the protein enhances the production... Agent: Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno

20110070617 - Liquid methanol fuel production from methane gas at bio-normal temperatures and presure: Through staged and monitored control of gas, liquid, and solid source materials, the highly-efficient enzymatic ‘natural factory’ of specific methanotropic bacteria, which evolved dual, alternative, metabolic channels, can be manipulated for human goals. The first stage sets these bacteria to producing liquid methanol by oxidation of methane gas under aerobic... Agent:

20110070618 - Method for producing ethanol using raw starch: Disclosed are methods for producing high levels of alcohol during fermentation of plant material, and to the high alcohol beer produced.... Agent: Poet Research, Inc.

20110070619 - Fermentation of a lignocellulose-containing material: The invention relates to a process of fermenting a hydrolysed pre-treated lignocellulose-containing material to produce a fermentation product.... Agent: Cofco Ltd.

20110070620 - Substrates comprising switchable ferromagnetic nanoparticles: In a process for producing organic substrate particles bonded to switchable ferromagnetic nanoparticles with a mean particle diameter in the range from 10 to 1000 nm, the ferromagnetic nanoparticles used are those nanoparticles which are nonferromagnetic at first, but become ferromagnetic when the temperature is lowered, these at first nonferromagnetic... Agent: Basf Se

20110070621 - Multivalent clostridial toxins: The present invention is directed to multivalent Clostridial toxin comprising more than one binding domain directed to a cell surface molecule of a target cell. Such modified toxins are useful as therapeutic compositions to prevent exocytosis and secretion by the target cell. Conditions in which such compositions may be useful... Agent: Allergan, Inc.

20110070622 - Purification of collagenases from clostridium histolyticum liquid culture: The present invention provides a method for purifying Clostridium histolyticum collagenase type I and type II proteins from a complex mixture by subsequently performing a precipitation with ammonium sulfate, hydrophobic interaction chromatography, cation exchange chromatography, and anion chromatography. Conditions are provided which lead to a stabilized, partially purified preparation even... Agent:

20110070623 - Self-inactivating helper adenoviruses for the production of high-capactiy recombinant adenoviruses: The invention relates to reagents and methods for the generation of auto-inactivating helper adenoviruses that allow the development of cell systems for the generation of high-capacity recombinant adenovirus showing a reduced contamination by auxiliary adenoviruses.... Agent: Proyecto De Biomedicina Cima, S.l.

20110070624 - Microwave resonant absorption method and device for viruses inactivation: Virus inactivation is performed with a specific microwave frequency to induce a collective vibration of virus through microwave resonant absorption (MRA).... Agent: National Taiwan University

20110070625 - Novel fluorescent proteins and methods for using same: The present invention provides nucleic acid molecules encoding novel red fluorescent proteins from Entacmaea quadricolor and mutants thereof. Also of interest are proteins that are substantially similar to the novel red fluorescent proteins. In addition, host cells, stable cell lines and transgenic organisms comprising the nucleic acid molecules encoding the... Agent: EvrogenIPJoint Stock Company

20110070626 - Nucleic acid and amino acid sequences relating to staphylococcus epidermidis for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Wyeth

20110070627 - Composition for the cultivation of sophisticated bacteria: The present invention relates to a composition for the cultivation of sophisticated bacteria, preferably of the genus Bartonella, and to a method for the cultivation of these bacteria.... Agent: Eberhard-karls-universitaet Tuebingen Universitaetsklinikum

20110070628 - Biomass processign: A biomass processing system is disclosed, with an algae biomass growth container and a pyrolysis reactor for pyrolysis processing of the algae biomass. A conveying apparatus links the pyrolysis reactor and the biomass growth container for conveying at least part of at least one of the pyrolysis products from the... Agent:

20110070629 - Method for micropropagation of monocots based on sustained totipotent cell cultures: The present invention provides a method of micropropagating a monocotyledonous plant comprising: (a) cultivating an explant of tissue from a monocotyledonous plant shoot tip on a primary medium, wherein the explant has been pretreated with a cold temperature and the primary medium comprises auxin or auxin and cytokinin, to produce... Agent: The University Of South Carolina

20110070630 - Method for deracemization of enantiomer mixtures: The invention relates to a process for enzymatic deracemization of enantiomer mixtures of secondary alcohols by a combination of oxidation and reduction reactions by means of stereoselective alcohol dehydrogenases and the cofactors thereof, wherein one enantiomer of an optically active secondary alcohol is in a formal sense selectively oxidized to... Agent: Evonik Degussa Gmbh

20110070631 - Container transportation case and culture treating device: A container transportation case is used to carry in/out a culture container to/from a chamber of a culture treating device. A case body of the container transportation case has a container housing room in which the culture container can be arranged and the container housing room is in communication with... Agent: Nikon Corporation

20110070632 - Photo bioreactor and cultivation system for improved productivity of photoautotrophic cell cultures: c

20110070633 - Analytical tool, analytical tool pack, cartridge including plurality of packs, method of making analytical tool pack, analyzer, and mechanism for taking out object: The present invention relates to an analytical tool pack (1) including an analytical tool (13) accommodated in one or between a plurality of sealing sheets (12a, 12b). The analytical tool pack (1) includes a stopper portion (146) for holding the analytical tool (13) with the analytical tool (13) caused to... Agent: Arkray, Inc.

20110070634 - Biosensor: An inexpensive biosensor is provided that can realize an electrochemical analysis and perform measurement with high accuracy or convenience. The biosensor is an immunological sensor that enables measurement anywhere at anytime by anyone while keeping convenience. The biosensor includes: an electrode sensor unit 4 in which an electric conductive layer... Agent: Panasonic Corporation

20110070635 - Systems and methods of generating energy and fresh water from solar radiation: A combined solar reflector and desalination assembly is provided for generating energy and fresh water from solar radiation. The solar reflector assembly is configured to be deployed on a supporting body of liquid and to reflect solar radiation to a solar collector. A combined solar reflector and desalination assembly comprises... Agent: Advanced Lab Group Cooperative

20110070636 - Resilient member and device, in particular a bio film reactor: The present invention relates to a resilient member (FIG. 7b) and combination of resilient members into resilient devices. Particular embodiments of the present invention relate to a bio film reactor comprising a stack of bio film discs formed as a resilient member thereby allowing the stack of bio film discs... Agent: Grundfos Biobooster A/s

20110070637 - Thermal cycler: A thermal cycler includes a bearing element, a heating element, a first cooling element, and a temperature controller. The bearing element carries at least one reaction mixture. The heating element raises the temperature of the reaction mixture. The heating element includes a housing, at least one carbon nanotube structure and... Agent: Hon Hai Precision Industry Co., Ltd.

20110070638 - Apparatus and method for preparative scale purification of nucleic acids: Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to controllably generate bubbles that reduce the density of the cell debris and create a... Agent:

20110070639 - Method of designing hydrodynamic cavitation reactors for process intensification: The present invention describes an apparatus of Hydrodynamic cavitation, to be used as reactors to achieve tangible effect by producing tailored active cavities either transient or steady or both, in aqueous and non-aqueous media for intensification of the physical and chemical processes in homogenous and heterogeneous systems. An apparatus comprises... Agent: Hyca Technologies Pvt. Ltd.

20110070640 - Optimized high yield synthetic plasmids: One aspect of the current invention is an optimized synthetic mammalian expression plasmid with a mutated origin of replication (e.g. “mut” family of plasmids) comprising a therapeutic element, and a replication element. The therapeutic elements of this plasmid are operatively linked and located in a first operatively-linked arrangement. Additionally, the... Agent: Vgx Pharmaceuticals, LLC

20110070642 - Device and method for isolating and cultivating live cells on a filter or extracting the genetic material thereof: A device for isolating and cultivating live cells on a filter or for extracting the genetic material thereof includes: a filter holder (108) connected to a filter; a compartment (102) having an upper opening and a lower opening; and an element (110) that is mobile relative to the compartment for... Agent: Screencell

20110070641 - Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating, and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.... Agent:

20110070643 - Utilization of pharmacological chaperones to improve manufacturing and purification of biologics: The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of... Agent:

20110070644 - Monocyte-derived stem cells (mdsc) and methods of use thereof: Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof The uses of these biological materials include methods of treating disorders or... Agent:

20110070646 - Biomimetic cell scaffolds: This invention relates to biomimetic implants containing mammalian cells which are induced by their environment to produce gradients of diffusible factors. This may be useful in eliciting a physiological pro-angiogenic response which stimulates angiogenesis and revascularisation in tissue adjacent the implant, for example in therapeutic applications in which increased angiogenesis... Agent:

20110070645 - Compositions and methods for promoting the generation of pdx1+ pancreatic cells: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic... Agent: The General Hospital Corporation

20110070647 - Pluripotent stem cell that can be isolated from body tissue: Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.... Agent:

20110070648 - Method for cell expansion: The present invention relates to a method for cell expansion. More closely, it relates to a method for expansion of cells, such as mesenchymal stem cells, on microcarriers in a plastic bag bioreactor. The invention enables expansion to therapeutic amounts of stem cells. The method comprises the following steps: a)... Agent: Ge Healthcare Bio-sciences Ab

20110070649 - Method for manufacturing glycoproteins having human-type glycosylation: The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransfetase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed... Agent:

20110070650 - Method of enhancing homologous recombination of somatic cells and method of acquiring specific antibody: e

20110070651 - Recombinant viral vector for gene transfer into lymphoid cells: A recombinant herpesvirus, a method for producing the recombinant herpesvirus, and a pharmaceutical composition comprising the recombinant herpesvirus, are provided with a method for producing a recombinant herpesvirus using a BAC vector sequence. In addition, a vector comprising a herpesvirus genomic gene and a BAC vector sequence, a cell comprising... Agent:

  
03/17/2011 > 110 patent applications in 52 patent subcategories. listing by industry category

20110065083 - Compositions and methods for enhancing the viability of animal cells, tissues, and organ explants: Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site... Agent: Warsaw Orthopedic, Inc.

20110065084 - Integrated oxygen measurement and control for static culture vessels: A system and method for measuring and controlling oxygen in a culture vessel utilizes a non-invasive oxygen sensor and an agitator. A controller controls the agitator based on feedback supplied by the oxygen sensor. The agitator is used to increase oxygen transport into the liquid phase thereby raising the level... Agent:

20110065085 - Novel heparin entities and methods of use: The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a substrate via at least one heparin molecule, wherein said bound heparin entity is heparinase-1 sensitive.... Agent:

20110065095 - Anti-(influenza a virus subtype h5 hemagglutinin) monoclonal antibody: A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody... Agent: Fujirebio Inc.

20110065097 - Apparatus and method of contaminant detection for food industry: The present invention is a method and apparatus for contaminant detection in the food industry. Particularly, the method and apparatus involve collecting air samples containing aerosolized contaminate particles from a foodstuff and analyzing the sample for presence of a contaminate. Aerosol lab-on-a-chip and/or electronic nose devices are utilized for the... Agent:

20110065090 - Asymmetrically branched polymer conjugates and microarray assays: A method of detection comprising a conjugate of a randomly and asymmetrically branched dendritic polymer.... Agent: Anp Technologies, Inc.

20110065091 - Coronavirus, nucleic acid, protein, and methods for the generation of vaccine, medicaments and diagnostics: A new coronavirus is disclosed herein with a tropism that includes humans. Means and methods are provided for diagnosing subjects (previously) infected with the virus. Also provided are among others vaccines, medicaments, nucleic acids and specific binding members.... Agent:

20110065088 - Method and devices for rapid diagnosis of foot-and-mouth disease: A rapid immunoassay method and apparatus for detecting foot and mouth disease virus are disclosed. The method and test device permit pen-side testing of animals and provide test results within a relatively short time period. In a preferred embodiment, the method and apparatus provide a means for differentiating between FMDV-infected... Agent: Repulic Of Korea (national Veterinary Research & Qurantine Service)

20110065094 - Method and kit for detection/identification of virus-infected cell: Disclosed is a means for specifically detecting and identifying a virus-infected cell in a floating cell system by a simple manipulation and with high sensitivity. A virus-infected cell can be detected and identified by the following steps (1) to (5): (1) adding a first labeled antibody which has been labeled... Agent: National University Corporation Nagoya University

20110065099 - Method of pretreating specimen and immunoassay using the same: The present invention provides a method of pretreating a specimen, which allows measurement according to an immunoassay to be carried out on a specimen from nasal secretion while preventing non-specific reactions. According to this method, the specimen from nasal secretion is treated with a protease beforehand and then an immunoassay... Agent: Arkray, Inc.

20110065098 - Methods and reagent kits for improving accuracy of sample classification: The present invention relates to methods for increasing the accuracy of sample classification characterized by the detection of the protein YKL-40 and the protein MASP2 in the samples and methods for determining the efficacy of a drug in treating a cancer in an individual, as well as reagent kits for... Agent: Biaoyang Lin

20110065086 - Methods of producing homogeneous plastic-adherent aptamer-magnetic bead-fluorophore and other sandwich assays: Methods are described for assembly of DNA aptamer-magnetic bead (“MB”) conjugate plus aptamer-quantum dot (“QD”) aptamer-fluorescent nanoparticle or other aptamer-fluorophore, aptamer-chemiluminescent reporter, aptamer-radioisotope or other aptamer-reporter conjugate sandwich assays that enable adherence to glass, polystyrene and other plastics. Adherence to glass or plastics enables detection of surface-concentrated partitioning of fluorescence... Agent: Otc Biotechnologies, LLC

20110065087 - Novel hiv targets: A set of cellular genes that were identified by siRNA screening as being essential for Human Immunodeficiency Virus (HIV) infection. These genes are host cellular factors involved in DNA repair, specifically in the base excision repair pathway.... Agent:

20110065089 - Novel strain of sars-associated coronavirus and applications thereof: The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the... Agent: Universite Paris 7

20110065093 - Novel tool for the analysis of neural circuits: The application relates to an isolated transsynaptic virus expressing an exogenous fluorescent activity sensor. Preferably, the transsynaptic virus is a rhabdovirus, e.g. rabies virus, or a herpesvirus, preferably an alphaherpesvirus, e.g. pseudorabies virus. The fluorescent exogenous activity sensor used in the transsynaptic virus can be a fluorescent protein Ca2+ sensor,... Agent:

20110065092 - Use of nonviable particles comprising an internal control (ic) nucleic acid: The present invention relates to the use of non-viable particles (and in particular liposome particles, particles which are in the form of a viral protein coat, non-viable genetically modified organisms or particles made of synthetic polymers), comprising an internal control (IC) nucleic acid sequence as an internal control in nucleic... Agent: Ic Particles As

20110065096 - Viral diagnostic method and well for use in same: The present invention relates to a single flat-based well suitable for use in a viral diagnostic method. More particularly, the well has a planar or flat base, as opposed to a curved base. The invention also relates to a viral diagnostic method that employs such single wells. In an embodiment... Agent:

20110065120 - method and a reagent kit to improve the accuracy of sample classification: A method for increasing the veracity of classification by detecting protein YKL-40 and MASP2 levels in the samples, comprises detecting the content of the YKL-40 and MASP2 in the samples; the ratio of the content of YKL-40 to the that of MASP2 acted as variable, receiving the ROC curve according... Agent:

20110065111 - Compositions for use in genotyping of klebsiella pneumoniae: The present invention relates generally to identification and characterization of genotypes of Klebsiella pneumoniae and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent: Ibis Biosciences, Inc.

20110065107 - Detection of gleevec resistance: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for... Agent: Oregon Health & Science University

20110065118 - Drug screening using islet cells and islet cell progenitors from human embryonic stem cells: This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High quality populations of islet cells can be produced in commercial quantities for use in research,... Agent:

20110065117 - Mesothelioma specific transferred promoter and use thereof: Provided is a promoter showing transcriptional activity in a mesothelioma-specific manner and showing low transcriptional activity in other kinds of cancer cells and normal cells including mesothelium. Also provided are applications of the promoter, and more specifically, a gene therapy vector and a therapeutic agent for mesothelioma each including the... Agent: National University Corporation Okayama University

20110065116 - Method for detecting atp: Methods are provided for detection of concentrations of less than 3.4 picomolar of adenosine triphosphate (ATP) using recombinant luciferase in the luciferin-luciferase reaction. Aspects include a low pH composition for use in detecting the presence of ATP. The low pH composition can include low concentrations of detergents and can be... Agent:

20110065112 - Method for identifying lineage-related antibodies: In certain embodiments, the method may comprise: a) obtaining the antibody sequences from a population of B cells; b) grouping the antibody sequences to provide a plurality of groups of lineage-related antibodies; c) testing a single antibody from each of the groups in a bioassay and, after the first antibody... Agent:

20110065110 - Method for the extraction and purification of nucleic acids on a membrane: The invention relates to a method for the extraction and detection of nucleic acids on a membrane, making it possible to identify the microorganisms present in low concentration in a liquid or gaseous medium, as well as a novel lysis composition comprising guanidium chloride and between 0.1 and 1% N-Lauroyl-Sarcosine... Agent: Millipore Corporation

20110065115 - Methods for identifying an increased likelihood of recurrence of breast cancer: Methods of identifying a mammal having an increased likelihood of recurrence of breast cancer includes identifying in a breast tissue sample of the mammal expression of at least two genes selected from the group consisting of Hs.125867 (EVL), Hs.591847 (NAT1), Hs.208124 (ESR1), Hs.26225 (GABRP), Hs.408614 (ST8SIA1), Hs.480819 (TBC1D9), Hs.504115 (TRIM29),... Agent: University Of Louisville Research Foundation, Inc.

20110065101 - Multiple-sample microfluidic chip for dna analysis: Aspects of the disclosure provide a microfluidic chip. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain for electrophoretic separation. The first domain includes at least a first reaction reservoir designated for PCR amplification based on a first... Agent: Lockheed Martin Corporation

20110065105 - Novel transcription factor-based biosensor: The present invention provides for a system comprising a BmoR transcription factor, a σ54-RNA polymerase, and a pBMO promoter operatively linked to a reporter gene, wherein the pBMO promoter is capable of expression of the reporter gene with an activated form of the BmoR and the σ54-RNA polymerase.... Agent: The Regents Of The University Of California

20110065102 - Osteoarthritis-sensitive gene: It is an object of the present invention to provide a method and kit for diagnosing osteoarthritis which involves genetic diagnosis or hemodiagnosis. The present invention provides a method for diagnosing a genetic susceptibility of a subject to osteoarthritis, which comprises detecting at least one polymorphism selected from polymorphisms existing... Agent: Riken

20110065104 - Real-time assays of neuro-humoral factors to assess cardiovascular stress: The present invention relates to rapid assays for neuro-humoral factors modulated in response to cardiovascular stress and integration of data obtained from such assays to provide profiles of response to cardiovascular stress that can guide therapy.... Agent:

20110065106 - Recombinase polymerase amplification: This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of the bacterial RecA and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods has the advantage of... Agent: Twistdx, Inc.

20110065113 - Recurrent gene fusions in prostate cancer: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusions as diagnostic markers and clinical targets for prostate cancer.... Agent: The Regents Of The University Of Michigan

20110065119 - Reverse progeny mapping: Provided is a method for mapping traits in organisms, in particular in plants. The method comprises a) providing a population of SDR-0 organisms, in particular plants, that each arise from one member of a population of unreduced cells resulting from second division restitution, in particular a population of unreduced spores;... Agent:

20110065109 - Rna interference mediating small rna molecules: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like... Agent: Max-planck-gesellschaft Zur Foerderung Der Wissenschaften E.v.

20110065114 - Steroidogenesis modified cells and methods for screening for endocrine disrupting chemicals: u

20110065100 - Transcription biomarkers of biological responses and methods: This invention provides transcription regulatory control sequences, the activity of which function as biomarkers for a variety of biological responses. This invention also provides expression constructs in which a biomarker transcription regulatory sequence is operably linked with a sequence for a reporter. Cells that comprise these expression constructs can be... Agent: Switchgear Genomics, Inc., A Delaware Corporation

20110065108 - Urine transport medium: A method of stabilizing a patient sample such as a urine sample to prevent degradation of nucleic acids for subsequent analysis for pathogen detection involves adding a stabilizing solution to an aliquot of the sample. A stabilizing solution comprising a chaotrope, a non-ionic detergent, and a buffer preserves urine samples... Agent: Siemens Healthcare Diagnostics Inc.

20110065103 - Use of rna for reprogramming somatic cells: The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically, the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in particular pluripotency, by introducing RNA encoding factors inducing the de-differentiation of somatic... Agent:

20110065122 - Method for accessing microbial diversity: A method of interfering with quorum sensing regulation of genes to promote cell growth is disclosed. The method of is aimed at accessing microbial biodiversity. The method involves obtaining an environmental sample comprising at least one novel (uncultivated in the laboratory) microorganism, contacting the environmental sample with an effective amount... Agent: Fraunhofer Usa, Inc.

20110065121 - Method for the detection of apoptosis: Methods for the detection of apoptosis by measuring apoptotic bodies shed by apoptotic cells are provided, as are kits to carry out such methods.... Agent:

20110065123 - Methods for diagnosis of clostridium difficile and methods and vectors for recombinant toxin expression: Cell-based methods for rapid real time assay of a presence of Clostridium difficile toxin and/or cells are provided, using an assay having a toxin-enhancing antibody and a sensitive cell line carrying FcyR receptors, and kits for this assay. An ultrasensitive cell based immunocytotoxicity assay for detecting less then 1 pg/ml... Agent:

20110065125 - Controlled platelet activation to monitor therapy of adp antagonists: A method is provided of determining whether an individual has reduced ability to form platelet thrombi due to inhibition of platelet activation initiation, signal transduction and/or GPIIb/IIIa blockade. A blood sample is obtained from the individual being assessed. The blood sample is mixed in combination with 1) an anticoagulant; 2)... Agent: Accumetrics, Inc.

20110065124 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses: The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of... Agent: Millennium Pharmaceuticals, Inc.

20110065126 - Substance-immobilizing substrate, substance-immobilized subtrate, and analysis method: The present invention relates to a substance-immobilizing substrate for immobilizing a substance to be detected by chemiluminescence. The substance-immobilizing substrate of the present invention comprises a metal portion composed of at least one metal selected from the group consisting of chromium and molybdenum, or an alloy of the metal on... Agent: Riken

20110065129 - Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.... Agent:

20110065130 - Diagnosing and grading gliomas using a proteomics: The present invention provides for a proteomic approach to grading gliomas, and for predicting patient survival. In addition to employing global protein expression patterns, such as by mass spectrometry, particular target proteins whose expression is altered in various gliomas can be used to predict the stage/classification of a glioma, as... Agent:

20110065131 - Assays for mutagenesis detection: The disclosure provides methods, systems, and kits for assaying an agent for mutagenic properties. The methods systems and kits utilize a DEL selectable marker and a colorimetric detection systems. Also included are methods systems and kits that utilize a DEL selectable marker and a regent that detects mitochondrial activity.... Agent: The Regents Of The University Of California

20110065132 - Identification of actinobacillus actinomycetemcomitans antigens for use in the diagnosis, treatment and monitoring of periodontal diseases: Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans.... Agent: University Of Florida Research Foundation

20110065127 - Detection of degradative enzymes and biomolecules in bodily fluids: Provided herein are methods, kits and compositions useful in detecting degradative enzymes and biomolecules in bodily fluid samples.... Agent: The Regents Of The University Of California A Cali Fornia Corporation

20110065128 - Methods for assessing cdk5 activation and function: As described herein, signaling events occurring in neurons or at neuronal synapses have been identified that involve Cdk5 and various other molecules which bind to, are activated by, and/or activate Cdk5. Of particular relevance are interactions that stimulate calpain cleavage of p35 into p25, which binds Cdk5 in pathologic states.... Agent:

20110065133 - O-ring systems and methods for quantification of multiplex biomarkers in multiple samples: Kits and methods of using O-rings having apertures are provided herein. O-rings are useful for incubating with a sample fluid potentially having one or more biomarkers, in order to detect the presence of the biomarkers. O-rings can be readily organized in a trackable manner prior to and during incubation with... Agent:

20110065134 - Synthetic peptides immuno-reactive with rheumatoid arthritis auto-antibodies: Embodiments of the present invention relate to a three dimensional matrix of selected, synthetic peptide mimic sequences that are preferentially recognized by auto-antibodies, specifically by autoimmune antibodies, to be detected in patients afflicted with rheumatic arthritis, enabling enhanced sensitivity and specificity in detection of these antibodies in pre-symptomatic patients, in... Agent: Sq Diagnostics Systems Inc.

20110065135 - Liposome composition, its production process, and method for analyzing analyte using the same: A liposome composition capable of including a chemical substance such as an electrochemiluminescent substance in an internal aqueous phase of the liposome at a higher concentration, and a production method thereof, as well as an analytical method of an analyte that enables an analyte to be analyzed with a high... Agent:

20110065136 - Methods and devices for detecting glomerulonephritis and associated disorders: Methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from... Agent: Rules-based Medicine, Inc.

20110065137 - Methods and devices for detecting obstructive uropathy and associated disorders: Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample... Agent: Rules-based Medicine, Inc.

20110065139 - diagnostic device for identifying rupture of membrane during pregnancy: A diagnostic device is provided for distinguishing between amniotic fluid and urine in female secretion. The device can be employed as a panty shield or can be adhered onto a panty shield or can be employed in a simple pad that is pressed against a substrate provided with female secretion.... Agent:

20110065138 - Quantitative method for detecting yessotoxins in fishery products on based on the activation that the toxin produces in cellular phosphodiesterases and therapeutic use of this activation: The present invention relates to a quantitative method for detecting yessotoxins in fishery products based on the activation the toxin produces on cellular phosphodiesterases and the therapeutic use of this activation. The cellular target of yessotoxin (YTX) and its analogs is the activation of phosphodiesterases (PDEs). The PDEs-YTX bond produces... Agent: Universidade De Santiago De Compostela

20110065140 - Programmable electromagnetic array for molecule transport: An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more... Agent:

20110065141 - Method of diagnosing pancreatic cancer with the use of n-binding type sugar chains: The present invention is to provide a novel marker for diagnosing pancreatic cancer, a method for determining if a subject has pancreatic cancer utilizing the marker, etc. The present inventors collected blood from patients of 78 cases in total including patients of 24 cases with pancreaticobiliary-duct benign disorder (16 gallstone... Agent: Sumitomo Bakelite Company Limited

20110065144 - Method of measuring effects of components on cell reactive oxygen species production: A method of determining the effects of a test component on intracellular ROS levels. The method can be used in marketing or in screening for useful components in reducing ROS levels in cells adversely affected by increased ROS generation.... Agent: Colgate-palmolive Company

20110065143 - Multiphoton scanning flow cytometer for multicellular aggregates: A flow cytometry system suitable for characterizing multicellular aggregates during culture and before implantation combines a low shear flow channel with a multiphoton laser scanning microscope, the latter permitting the characterization of interior and exterior cells in optical isolation from other cells for a representative sampling of fluorescent activity. Imaging... Agent:

20110065142 - Sebocytes, sebocyte-cell line and uses thereof: Adipose cells (sebocytes) are described, The invention especially relates to sebaceous gland cells and to a sebaceous gland cell line with the property of being continuously grown over many sub-cultures. The sebocytes are excellently suited for useful applications.... Agent:

20110065145 - Water mamagement: A method for detecting and enumerating viable microorganisms in a sample suspected of containing said microorganisms (1) contacting said microorganisms of said sample with at least one repair compound and a growth medium, and (2) incubating the product of steps (1), and (3) detecting and quantifying said viable microorganisms, in... Agent: Basf Se

20110065146 - Expression of hiv polypeptides and production of virus-like particles: The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation... Agent: Novartis Vaccines And Diagnostics, Inc.

20110065147 - Methods and reagents for modulating cholesterol levels: The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).... Agent:

20110065148 - Peptides and uses thereof: The present invention relates to monovalent fucose-binding peptides. The peptides may be recombinantly produced or chemically synthesized. Preferably the peptides are derived from a lectin, in particular Aleuria aurantia lectin. Furthermore the invention relates to methods for producing the peptides, assays using the peptides for diagnosis of disorders, as well... Agent:

20110065149 - Method of producing fused protein: Described herein is a polynucleotide encoding a fusion protein comprising two or more polypeptide domains and a polypeptide linker joining the domains, wherein the sequence of the polynucleotide encoding the polypeptide linker is selected such that when the mRNA transcribed from the polynucleotide is translated in a host cell transfected... Agent: Chugai Seiyaku Kabushiki Kaisha

20110065151 - Nucleic acid amplification with single strand dna binding protein: A method is disclosed in which circular DNA molecules are amplified preferentially in a mixture of circular DNA molecules and linear DNA molecules by the inclusion of single strand DNA binding protein.... Agent: Ge Healthcare Bio-sciences Corp.

20110065150 - Reaction vessel comprising electrically conducting polymer as a heating element: A reaction vessel for conducting a chemical or biochemical reaction, such as a polymerase chain reaction wherein electrically conducting polymer is arranged to act as a heating element. The profile of the electrically conductive polymer differs in different regions of the vessel so as to control thermal gradients. The profile... Agent: Enigma Diagnostics Limited

20110065152 - Process for production of galactooligosaccharides (gos): The present invention deals with an improved process for the production of high yield of pure Galactooligosaccharides using microbial whole cells in a reactor with cross flow hollow fiber microfiltration system. The process is economical as cell biomass is used repeatedly and eliminated the need to carry out downstream processing... Agent:

20110065153 - Method of producing l-lysine: The ability and speed with which a coryneform bacterium can produce L-lysine are improved when the coryneform bacterium contains an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized. This is accomplished by successively enhancing the DNA coding for dihydrodipicolinate reductase, the DNA coding for dihydrodipicolinate synthase,... Agent:

20110065154 - Deracemisation of amines: The present invention relates to a method for the deracemisation or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. The invention also provides a method for selecting a suitable... Agent:

20110065155 - Productions of organic acid salts from digested biomass and their uses and self cleaning emitter therefor: A method and means of producing organic acids (such as acetic acid) and calcium-, magnesium-, iron-organic acid salts (mostly acetates) from readily available, digested biomass (or biomass rich trash or waste) and limestone, or magnesium rich stone, or iron oxides is described. The invention also relates to the use of... Agent:

20110065156 - Process of production of vanillin with immobilized microorganisms: m

20110065157 - Photobioreactor for algae growth: The present invention provides a flow-through photobioreactor containing at least one thermoplastic multi-wall sheet having an upper layer and a lower layer having arranged there between at least two sidewalls, at least one inner wall and two or more end caps. Also provided is a process for the production of... Agent:

20110065158 - Regulation of plant metabolism: We describe a plant and plant cell which is modified to enhance the production of plant-derived oil in particular in non-seed tissue and including methods for the processing of plant derived biomass materials.... Agent: The University Of York

20110065159 - Biomass hydrolysis: High-yielding method for chemical hydrolysis of lignocellulose into monosaccharides. The process of the invention can additionally be applied to cellulose, xylan and related biomass polysaccharides, such as galactan, mannan, or arabinan. The method is employed for hydrolysis of a biomass polysaccharide substrate. The process is carried out in an ionic... Agent:

20110065160 - Treatment of eukaryotic cellular biomass: The application describes a process for treating a eukaryotic cell-derived biomass-containing stream including: (i) passing the stream through a chamber; (ii) pressurizing_the stream; (iii) introducing a gas into the pressurized stream, the gas being soluble within the eukaryotic cell-derived biomass; and (iv) depressurizing the stream to cause the solubilised gas... Agent: Shepherd, Samuel

20110065161 - Bipolar solid state marx generator: A high-voltage bipolar rectangular pulse generator using a high efficiency solid-state boosting front-end and an H-bridge output stage is described. The topology of the circuit generates rectangular pulses with fast rise time and allows easy step-up input voltage. In addition, the circuit is able to adjust positive or negative pulse... Agent: Board Of Regents, The University Of Texas System

20110065162 - Ire-1alpha inhibitors: Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.... Agent: Mannkind Corporation

20110065163 - Small enzyme-containing granules: The invention provides small enzyme-containing granules having an inorganic salt core and an enzyme-containing layer coated over the core, and methods for producing such granules. The majority of the enzyme granules are less than 300 μm in diameter. The granules are suitable for incorporation into compositions such as cleaning, textile... Agent:

20110065164 - Double-labelling agents based on vinyl sulphone: The invention relates to labelling agents containing a compound with two labelled molecules and a vinyl sulphone group. The invention also relates to the compounds, the method for obtaining these and the uses thereof in the marking of biomolecules and, more specifically, proteins.... Agent: Universidad De Granada

20110065165 - Method for culturing planktonic microalgae: The present invention relates to a method for culturing planktonic microalgae, comprising: culturing planktonic microalgae with a culture substrate containing a visible light transmissive fiber with a hydrophilic surface, where a space diameter between the fibers is from 10 μm to 500 μm.... Agent: Hamamatsu Photonics K.k.

20110065167 - Degradation of hydrophobic ester pesticides and toxins: The present invention relates to methods for degrading hydrophobic ester pesticides and toxins. In particular, the present invention relates to the use of insect esterases, and mutants thereof, in the bioremediation of hydrophobic ester pesticides and toxins residues, such as pyrethroid residues, contaminating the environment and horticultural commodities.... Agent: Commonwealth Scientific And Industrial Research Organisation

20110065166 - Nox removal system for biogas engines at anaerobic digestion facilities: Provided herein are methods, devices and systems comprising a reactor that is operatively connected to: (a) a biogas production unit for converting waste to a biogas stream; and (b) an engine that utilizes the biogas stream from the biogas producing unit to produce energy and an engine exhaust.... Agent: Biogas & Electric

20110065168 - Preparation of pregabalin and related compounds: Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.... Agent: Pfizer Inc

20110065169 - Apparatus for housing an organ during evaluation and preservation: A vessel for housing an organ such as lungs from a mammal ex-vivo, for evaluation or preservation. A liquid solution suitable for evaluation or preservation of the lungs surrounds the organ, at least partly. The solution is circulated via an outlet and an inlet. Two pressure chambers are arranged between... Agent: Vivoline Medical Ab

20110065170 - Device for the preservation of a hepatic graft in normothermia: The invention relates to a device for the preservation of a hepatic graft in normothermia comprising a receptacle in which said hepatic graft is housed in a preservation solution, an arterial perfusion circuit, a portal perfusion circuit, at least one flow sensor of a perfusion circuit, and at least one... Agent: Fundacio Privada Clinic Per A La Recerca Biomedica

20110065171 - Methods and devices related to a regulated flow electroporation chamber: The electroporation chamber and its related devices combine the features of an electroporation chamber that acts as a manifold for regulation of sample flow with those of a flow electroporation device to form a regulated flow electroporation device. The invention further comprises a novel regulated flow electroporation chamber that enables... Agent:

20110065172 - Direct mixing and injection for high throughput fluidic systems: A system and method of mixing and injecting discrete sample mixtures into a flow cytometer or other sample analysis apparatus may generally comprise a sample injection guide coupling a liquid handling apparatus with a sample analysis apparatus and facilitating injection of discrete sample mixtures into a fluidic system of the... Agent: Saryna Biotechnologies LLC

20110065174 - Hepatitis c virus codon optimized non-structural ns3/4a fusion gene: Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nucleic acids and peptides, as well as methods of making and using the aforementioned compositions... Agent: Chrontech Pharma Ab

20110065173 - Vector: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.... Agent: Oxford Biomedica (uk) Limited

20110065175 - Artificially synthesized peptide: A short synthetic vector peptide of 25 residues has been developed comprising hydrophobic domain and a novel, nuclear localization signal for efficient delivery, devoid of any cytotoxicity. Using the vector peptide, the oligonucleotide/peptide complexes got delivered evenly in cytoplasm and nucleus in less than an hour and finally localizing completely... Agent: Indian Council Of Agricultural Research

20110065178 - Dendritic cell potentiation: A molecule capable of potentiating immune responses is described, as well as methods for using the molecule to enhance immune responses and enhance dendritic cell function. Also described are compositions containing the molecule and methods for using the compositions to treat or immunize individuals.... Agent: Mayo Foundation For Medical Education And Research

20110065180 - Ex-vivo priming for generating cytotoxic t lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen... Agent:

20110065176 - Human monoclonal antibody neutralizing vascular endothelial growth factor receptor and use thereof: The present invention relates to human monoclonal antibodies neutralizing vascular endothelial growth factor receptor and the use thereof. More specifically, relates to human ScFv molecules neutralizing vascular endothelial growth factor receptor, and a composition for inhibiting angiogenesis and a composition for treating cancer, which contain the human ScFv molecules. The... Agent: Korea Research Institute Of Bioscience And Biotechnology

20110065183 - Methods and apparatus for isolating platelets from blood: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma.... Agent: Hanuman LLC

20110065181 - Methods and apparatus for segregation of particles: The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are accommodated in a passage bounded by a first step, but at least some of the particles are unable to pass through a... Agent: Parsortix, Inc.

20110065182 - Modified dna cleavage and methods for use: Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic centers separated by a β-bridge where the β-bridge contains at least one mutation having an effect of altering enzyme... Agent: New England Biolabs, Inc.

20110065177 - Novel collectin: Novel collectin related molecules i.e., a novel collectin gene comprising a nucleotide sequence set out in SEQ ID NO: 1, and a novel collectin comprising an amino acid sequence set out in SEQ ID NO: 2, which are expected to exhibit anti-bacterial, anti-viral activity or the like especially in human... Agent: Fuso Pharmaceutical Industries, Ltd.

20110065179 - Transgene delivering retrovirus targeting collagen exposed at site of tissue injury: A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at... Agent: University Of Southern California

20110065184 - Human host cell for producing recombinant proteins with high quality and quantity: The present invention relates to a human host cell generated from fusion of a human embryonic kidney-derived cell and a human B-cell-derived cell, by using genetic engineering techniques. The human host cell with stable characteristics well preserved may be efficiently used to produce heterologous desired recombinant protein-based pharmaceuticals.... Agent: Celltrion, Inc.

20110065186 - Ex-vivo priming for generating cytotoxic t lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen... Agent:

20110065187 - Ex-vivo priming for generating cytotoxic t lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen... Agent:

20110065185 - Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells: Recombinant immunotoxins are fusion proteins composed of the Fv domains of antibodies fused to bacterial or plant toxins. RFB4 (Fv)-PE38 is an immunotoxin that targets CD22 expressed on B cells and B cell malignancies. The present invention provides antibodies and antibody fragments that have improved ability to bind the CD22... Agent: The Government Of U.s.a As Represented By The Secretary Of The Dept Of Health And Human Services

20110065188 - Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same: A method is provided for controlling the survival, proliferation, and/or differentiation of hepatic progenitors in vitro by using specific types of mesenchymal feeder cells or one of more of the paracrine signals produced by those feeders.... Agent: University Of North Carolina At Chapel Hill

20110065189 - Lacritin-syndecan interactions: The present invention relates to methods and compositions useful for the regulation of lacritin, syndecan, and lacritin-syndecan interactions and the signaling pathway downstream of lacritin-syndecan interactions. The invention also relates to regulating lacritin-syndecan interaction to regulate ocular cell survival in response to an insult or injury, in protecting against ocular... Agent: University Of Virginia Patent Foundation

20110065190 - Blood platelet induction method: A novel induction method that effectively produces platelets from platelet precursor cells (e.g., hemopoietic stem/precursor cells) is disclosed. The method includes culturing platelet precursor cells in a culture solution in which a composite membrane is immersed so that the platelet precursor cells differentiate into platelets, the composite membrane including a... Agent: Osaka University

20110065191 - Isolated nucleic acids encoding farnesyltransferase polypeptides: The present invention provides novel isolated FT polynucleotides and polypeptides encoded by the FT polynucleotides. Also provided are the antibodies that immunospecifically bind to a FT polypeptide or any derivative, variant, mutant or fragment of the FT polypeptide, polynucleotide or antibody. The invention additionally provides methods of constructing transgenic plants... Agent: Performance Plants, Inc.

20110065192 - Embryonic stem cell line and method for preparing the same: An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.... Agent: H Bion Co., Ltd.

  
03/10/2011 > 103 patent applications in 50 patent subcategories. listing by industry category

20110059429 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Lifeline Scientific, Inc.

20110059430 - Cross-spot: The invention relates to an in vitro method for measuring the presence of an antigen indicative for the presence of an infectious agent, and preferably a medical condition or disease in a sample using an immune effector cell capable of producing an immune effector molecule following stimulation by an antigen.... Agent:

20110059431 - Non-enzymatic detection of bacterial genomic dna: The present invention relates to methods for detecting for the presence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes blocking strands to inhibit target rehybridization to detect double stranded genomic DNA.... Agent: Northwestern University

20110059435 - methods for beaming: Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients.... Agent: The John Hopkins University

20110059462 - Automated particulate concentration system: An automated system for concentrating potentially harmful substances from various water types or other non-viscous liquids to facilitate detection of those substances is disclosed herein. The automated system comprises a water pressure driven or pump driven concentration unit that filters the test fluid through a hollow-fiber filter. Material collected on... Agent: University Of South Florida

20110059459 - Brca1 mrna expression predicts survival in patients with bladder cancer treated with neoadjuvant cisplatin-based chemotherapy: The invention relates to methods for predicting the clinical outcome of a patient which suffers from bladder cancer based on the expression levels of BRCA1 wherein high BRCA1 expression levels are indicative of a poor prognosis. Moreover, the invention relates to methods for predicting the response to chemotherapy of a... Agent:

20110059439 - Composition and method for imaging stem cells: An expression vector, comprising a first reporter nucleic acid sequence operably linked to a first expression control sequence comprising a promoter; and a second reporter nucleic acid sequence operably linked to a second expression control sequence that comprises a response element that is activated or inactivated as one or more... Agent: General Electric Company

20110059458 - Compositions and methods for catalyzing dna-programmed chemistry: The present invention relates compositions and methods that are useful in catalyzing DNA-Programmed Chemistry (or Nucleic Acid-templated chemistry) for use in therapeutic and diagnostic applications.... Agent:

20110059448 - Compositions and methods for determining cancer stem cell self-renewal potential: In alternative embodiments, the invention provides compositions and methods for determining the self-renewal potential of a cancer stem cell (CSC) through analysis of the cross-talk between cell self-renewal pathways leading to deregulation and enhanced self-renewal of the CSC, or for predicting the drugability (susceptibility to a drug) of a CSC,... Agent: The Regents Of The University Of California

20110059451 - Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms: The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome.... Agent: University Of Louisville Research Foundation

20110059454 - Fluorescence energy transfer by competitive hybridization: A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which have a fluorophore on one probe and a quencher on the other. The fluorophore and quencher are... Agent: Quest Diagnostics Investments Incorporated

20110059443 - Fluorescent gfp variant displaying highly increased fluorescence intensity without a spectral shift: The present invention relates to a nucleic acid molecule encoding a polypeptide having a fluorescence emission activity with a maximum emission at 505 to 515 nm, wherein said nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule encoding a polypeptide having the amino acid... Agent: Helmholtz Zentrum M&#xfc Nchen Deutsches Forschungszentrum F&#xfc R Gesundheit Und Umwelt (gmbh)

20110059460 - Infection mediated foam dissolution rate measurement: The subject invention concerns methods and materials for determining the presence or absence of bacterial or fungal infection in a blood sample. In one embodiment, a method of the invention comprises exposing an anticoagulant treated blood sample to freezing the sample to a solid, followed by thawing of the sample... Agent: Imigene, Inc

20110059450 - Labeled nucleotide analogs and uses therefor: Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.... Agent: Pacific Biosciences Of California, Inc.

20110059444 - Magnetic detection of small entities: A novel detection or quantifying method for biological entities or molecules such as, but not limited to, DNA, microorganisms and pathogens, proteins and antibodies, that by themselves are target molecules or from which target molecules are extracted, comprises the steps of i) forming target molecule-dependent volume-amplified entities, ii) allowing magnetic... Agent:

20110059446 - Method for determining methylation at cytosine residues: The present invention refers to a method and reagent kits for determining methylation at cytosine (dC) residues in nucleic acids, such as DNA.... Agent: Ludwig-maximilians-universitaet Muenchen

20110059432 - Method for providing dna fragments derived from a remote sample: Aspects of the present invention relate to compositions and methods for providing DNA fragments from a remote sample. In particular aspects a remote sample comprising DNA is provided, DNA is isolated from the remote sample, and the isolated DNA is treated in a way which allows differentiation of methylated and... Agent: Epigenomics Ag

20110059433 - Method for the detection and characterization of microorganisms on a filter: The present invention relates to a method for the specific detection on a filter of one or more microorganisms present in a fluid, characterized in that it comprises the following steps: a) contacting the microorganisms present in the fluid or on the surface with the filter; b) amplifying specifically the... Agent:

20110059447 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Genenews Corporation

20110059438 - Method of preparing dna fragments and applications thereof: e

20110059449 - Methods and compositions for diagnosing and monitoring transplant rejection: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same... Agent: Xdx, Inc.

20110059455 - Methods and compositions for direct chemical lysis: A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive... Agent: Becton, Dickinson And Company

20110059436 - Methods for sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Life Technologies Corporation

20110059461 - Methods of diagnosing myelodysplastic syndrome (mds) or leukemia using nucleic acids or fragments encoding flt3 kinase: To provide a nucleic acid encoding a receptor protein kinase, wherein the nucleic acid has tandem duplication in a nucleotide sequence of a juxtamembrane and is useful for diagnosis of leukemia; a polypeptide encoded by the nucleic acid; an antibody capable of specifically binding to a region encoded by the... Agent:

20110059452 - Methods of screening for gastric cancer: Method and systems are provided for diagnosing or monitoring a gastric cancer in a subject. Such methods include providing a biological sample from the subject; determining an amount in the sample of at least one biomarker, selected from the group consisting of: CDH17 and OLFM4; and comparing the amount of... Agent: Seoul National University

20110059441 - Methof of producing bioactive paper: The present disclosure relates to methods for attaching bioactive agents to paper products by contacting the paper with a solution comprising colloidal support particles where said colloidal support particles are associated with bioactive agents. In specific embodiment of the disclosure, the colloidal support particles are functionalized poly(N-isopropylacrylamide) microgels. The disclosure... Agent: Mcmaster University

20110059445 - Mucosal gene signatures: Infliximab (IFX) is an effective treatment for Crohn's disease (CD) and ulcerative colitis (UC) not responding to standard therapy. Thirty percent to forty percent of patients however do not improve and the response is often incomplete. We identified mucosal gene signatures predictive of response to EFX using high-density oligonucleotide arrays.... Agent:

20110059442 - Multiplex detection of nucleic acids: Methods of detecting nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. Compositions, kits,... Agent: Advanced Cell Diagnostics, Inc.

20110059434 - P13k pathway mutations in cancer: Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations in eight genes were identified, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway; the alterations in the latter genes each occurred in different... Agent:

20110059437 - Pcr-based genotyping: A Mycoplasma bovis PCR-based genotyping method was developed that exploits the proximity of insertion sequences (IS) within the genome by using outward facing primers that selectively amplify sequences between IS elements. The method was applied to 16 field isolates of M. bovis, originating from pneumonic lung or arthritic joints, collected... Agent: Boehringer Ingelheim Vetmedica, Inc.

20110059453 - Poly(a) tail length measurement by pcr: Methods and kits for measuring the length of the poly(A) tail of selected target mRNA are disclosed herein. In preferred aspects the mRNA population is modified by addition of a tail comprising guanosine and inosine (G/I tailing). The added tail is used as a priming site for reverse transcription. The... Agent: Affymetrix, Inc.

20110059440 - Rapid analysis of variations in a genome: The invention provides a method useful for determining the sequence of large numbers of loci of interest on a single or multiple chromosomes. The method utilizes an oligonucleotide primer that contains a recognition site for a restriction enzyme such that digestion with the restriction enzyme generates a 5′ overhang containing... Agent: Ravgen, Inc.

20110059457 - Selective restriction fragment amplification: fingerprinting: The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. This technology can be applied to human,... Agent: Keygene N.v.

20110059456 - System for the cell-specific and development-specific selection of differentiating embryonic stem cells, adult stem cells and embryonic germline cells: The invention relates to a system for selecting differentiating embryonic or adult stem cells or embryonic germline cells in a cell-specific and development-specific manner, using a combination of resistance genes and detectable reporter genes under the common control of a cell-specific and/or development-specific promoter.... Agent: Axiogenesis Ag

20110059464 - Biomarker panel for prediction of recurrent colorectal cancer: The present invention provides a biomarker panel predictive of whether colorectal cancer is likely to recur or metastasize in an afflicted patient. By identifying the likelihood of recurrence, a treatment provider may determine in advance those patients who would benefit from certain types of treatment. The present invention further provide... Agent:

20110059463 - Serine and threonine phosphorylation sites: The invention discloses 726 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies that specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Cell Signaling Technology, Inc.

20110059467 - Controlled modification of semiconductor nanocrystals: A controlled valency semiconductor nanocrystal can have a desired number of compounds associated with it. The semiconductor nanocrystal can have exactly one compound associated with it, and the compound can have exactly one binding site for an affinity target. The semiconductor nanocrystal can be used to image single copies of... Agent: Massachusetts Institute Of Technology

20110059468 - Magnetic separation device for cell sorting and analysis: A magnetic sifter is adapted for manipulation of biological cells by providing a greater pore density at the edge of the sifter than at the center. Application of an external magnetic field to the sifter causes high magnetic fields and field gradients at the sifter pores. These conditions are suitable... Agent:

20110059469 - Anti-cldn6 antibody: The present invention relates to an antibody binding to Claudin6 (CLDN6) expressed on a cell membrane. The antibody of the present invention recognizes human CLDN6 present in a native form on cell membrane surface and exhibits cytotoxicity through ADCC and/or CDC activities against cancer cell lines highly expressing human CLDN6.... Agent:

20110059470 - Tumor microenvironment of metastasis (tmem) and uses thereof in diagnosis, prognosis and treatment of tumors: Disclosed are methods for determining the risk of tumor cells undergoing metastasis, for assessing the prognosis of a subject undergoing treatment for a localized tumor, and for determining a course of treatment for a localized tumor comprising detecting the presence of an endothelial cell, a macrophage, and an invasive tumor... Agent:

20110059471 - Antibody having an immune-enhancement function: The present invention provides a monoclonal antibody against FLJ32028, which binds specifically to the surfaces of regulatory T-cells (Treg) and especially to the surfaces of induced Treg. This monoclonal antibody can be used for a Treg-removal method or a Treg-removal apparatus. This monoclonal antibody can also be used as a... Agent: Medinet Co., Ltd.

20110059465 - Screening assays for agents that alter inhibitor of apoptosis (iap) protein regulation of caspase activity: The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The... Agent: Sanford-bumham Medical Research Institute

20110059466 - Support for electrophoresis including hydrophobic polymer membrane, and electrophoretic separation method using the same: There is provided a membrane electrophoresis which renders possible glycan analysis of polysaccharide and glycoprotein by separating protein, glycoprotein or polysaccharide by electrophoresis, followed by carrying out a glycan-releasing treatment of the membrane used in the electrophoresis, or a membrane electrophoresis which renders possible detection of the same by an... Agent: National Institute Of Advanced Industrial Science And Technology

20110059473 - Proteins with pteridine glycosyltransferase activity and analysis method using the same: The present invention relates to proteins with pteridine glycosyltransferase activity and an analysis method using the same. Since the proteins glycate tetrahydrobiopterin selectively through an enzyme reaction, the method enables quantitative analysis of tetrahydrobiopterin and oxides thereof at the same time or quantitative analysis of tetrabiopterin selectively.... Agent: Inje University Industry- Academic Cooperation Foundation

20110059472 - Reagents and methods for detecting influenza virus proteins: Antibodies that specifically bind to a peptide having an amino acid sequence as found at the N-terminus of the HA2 fusion peptide of the influenza A virus may be raised by inoculating a mammal with a conjugate of the peptide. In one embodiment, the conjugate comprises the peptide linked to... Agent:

20110059474 - Method for determining carbohydrate and kit for determining carbohydrate: It is intended to provide a method for determining a carbohydrate which enables more accurate determination of a carbohydrate. The invention for achieving this object is directed to a method for determining a carbohydrate using a digestive enzyme, characterized in that as the digestive enzyme, an animal-derived low-molecular-weight carbohydrate digestive... Agent: Nagasaki Prefectural And Municipal Universities Corporation

20110059475 - Stabilisation of blood cell conjugates: The invention relates to methods and kits for stabilising blood cell conjugates in blood samples for subsequent analysis. The invention particularly relates to methods and kits for use in fixing and stabilising platelet aggregates in blood samples, and methods for detecting the degree of platelet aggregation in a sample. The... Agent: The University Of Nottingham

20110059476 - Bioreactor for quantification of headspace voc content from cultures: A bioreactor for sampling the headspace above cells includes a glass reactor vessel having an interior space and a plurality of valves operatively coupled to the interior space of the glass reactor vessel. The bioreactor includes a sample holder configured to reside in the interior space. The interior space includes... Agent:

20110059477 - Fluorescent dye-labeled glucose bioprobe, synthesis method and usage thereof: Disclosed are a novel fluorescent glucose analogue, a method for the synthesis thereof and the use thereof. The novel fluorescent glucose analogue is labeled with fluorescent dye by O-1-glycosylation and via various linkers. The fluorescent glucose analogue can be applied to molecular bioimaging and a method for screening curative or... Agent: Snu R&db Foundation

20110059481 - Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells: A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the... Agent: Abbott Point Of Care, Inc.

20110059479 - Modulation of the integrin linked kinase signaling pathway to promote cardiac cell proliferation and self-renewal: The invention relates to a process for identification, amplification and differentiation of cardiac stem cells by utilizing an ILK based protocol. The invention further relates to a process for post myocardial infarction (IVII) remodeling by way of the integrin linked kinase (ILK) signaling pathway. Still further, the invention relates to... Agent:

20110059478 - Orphan nuclear receptor: The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and... Agent:

20110059480 - Use of an in vitro hemodynamic endothelial/smooth muscle cell co-culture model to identify new therapeutic targets for vascular disease: Methods and devices for applying hemodynamic patterns to human/animal cells in culture are described. Hemodynamic flow patterns are measured directly from the human circulation and translated to a motor that controls the rotation of a cone. The cone is submerged in fluid (i.e., cell culture media) and brought into close... Agent: Hemoshear, LLC

20110059482 - Sampling kit: The present invention relates to a kit for improving and facilitating sampling and handling of biological samples from sampling to analysis. The invention also relates to a method for selection and, optionally, enrichment of microbes for efficient and accurate analysis of a biological sample as well as a collection vessel.... Agent:

20110059483 - Molecular probe for imaging of pancreatic islets and use of the same: wherein A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, R1 represents a substituent that contains radioactive iodine, R2 represents either a hydrogen atom or a substituent different from that represented by R1, and R3 represents any one of a bond, a methylene group, and an oxymethylene... Agent: Arkray, Inc.

20110059487 - Engineered microorganisms and methods of use: The present invention provides, among other things, engineered microorganisms and methods that allow efficient conversion of soy carbohydrates to industrial chemicals by fermentation. In some embodiments, the invention provides microbial cells engineered to have increased efficiency in utilizing a soy carbon source (e.g., soy molasses, soy meal, and/or soy hulls)... Agent: Modular Genetics, Inc.

20110059486 - Non-splicing variants of gp350/220: Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use... Agent: Medimmune, LLC

20110059485 - Plasmids from thermophilic organisms, vectors derived therefrom, and uses thereof: The present invention is directed to a replicative, thermostable plasmid. In particular, the present invention is directed to a replicative, thermostable plasmid comprising a sequence derived from the pB6A plasmid and at least one functional unit comprising a sequence that is not found in plasmid pB6A.... Agent: Mascoma Corporation

20110059484 - Process for producing polypeptides: A process is described for producing a polypeptide heterologous to E. coli wherein E. coli cells comprising nucleic acid encoding the polypeptide are cultured in a culture medium while feeding to the culture medium a transportable organophosphate, such that the nucleic acid is expressed. The polypeptide is then recovered from... Agent: Genentech, Inc.

20110059488 - Anti-mpl antibodies: p

20110059489 - Method for fermentative production of n-acetyl-d-glucosamine by microorganism: N-Acetyl-D-glucosamine can be produced by cultivating a fungus capable of producing N-acetyl-D-glucosamine, such as Trichoderma hamatum AB 10282 strain (FERM BP-10623) or Trichoderma harzianum AB10283 strain (FERM BP-10624), in a culture medium supplemented with a carbon source other than chitin and chitin oligosaccharide and a nitrogen source to produce and... Agent: Hokko Chemical Industry Co., Ltd.

20110059490 - Polymerase compositions and uses: A composition having nucleic acid polymerase activity, which comprises an active nucleic acid polymerase and an excess amount of a non-functional mutant nucleic acid polymerase protein, wherein the non-functional mutant nucleic acid polymerase protein stabilizes the active nucleic acid polymerase against loss of polymerase activity.... Agent: Fermentas Uab

20110059491 - Beta-amylase, gene coding therefor and manufacturing method thereof: To provide novel β-amylase derived from a microorganism and a gene thereof. β-amylase derived from Bacillus flexus is provided.... Agent: Amano Enzyme Inc.

20110059492 - Polypeptides having alpha-amylase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having alpha-amylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20110059493 - Methods for making simvastatin and intermediates: The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.... Agent:

20110059494 - D4 desaturases and d5 elongases: Disclosed are methods and compositions related to ONC-T18, D4-desaturases, D5 elongases, their isolation, characterization, production, identification, and use for fatty acid production, as well as organisms containing these compositions and organisms expressing them.... Agent:

20110059496 - Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast: Promoter regions associated with the Yarrowia lipolytica glyceraldehyde-3-phosphate dehydrogenase (gpd) gene have been found to be particularly effective for the expression of heterologous genes in yeast. Promoter regions of a Yarrowia gpd gene shown to drive high-level expression of genes involved in the production of omega-3 and omega-6 fatty acids... Agent: E. I. Du Pont De Nemours And Company

20110059495 - Manipulation of an alternative respiratory pathway in photo-autotrophs: Exemplary methods for increasing TAG production in an algal cell during imbalanced growth conditions are provided. Some methods comprise knocking out an AOX gene, wherein the AOX gene produces an amino acid sequence having substantial similarity to the amino acid sequence of SEQ. ID. NO. 2. In further methods, the... Agent:

20110059497 - Apparatus and process for fermentation of biomass hydrolysate: A process for converting biomass hydrolysate into biofuel, the process comprising the steps of: obtaining a biomass hydrolysate solution comprising monosaccharides; immobilizing Pachysolen tannophilus; contacting the solution with the immobilized Pachysolen tannophilus; and recovering a fermented biofuel.... Agent:

20110059498 - Method and device for producing electricity and conversion products, such as ethanol: The invention relates to a method for producing electricity and conversion products such as ethanol, comprising the steps of: i) separating a starch source into a starch-rich fraction and a residual fraction; ii) heating the starch-rich fraction for the purpose of gelling the starch; iii) releasing the gelled starch from... Agent:

20110059499 - Microbial alcohol production process: The invention relates to the production of alcohols by microbial fermentation, particularly to production of alcohols by microbial fermentation of substrates comprising CO. It more particularly relates to processes for the production of alcohols from their corresponding acids in the presence of a substrate comprising CO. In particular embodiments, a... Agent: Lanza Tech New Zealand Limited

20110059500 - Method for separating immunomagnetic bead labeled particulates: Disclosed is a method for separating immunomagnetic bead labeled particulates. A carrier board is formed with at least one flow channel structure, which includes an inner reservoir, an outer reservoir, and at least one micro flow channel in communication with the inner reservoir and the outer reservoir. The method includes... Agent: National Taiwan University

20110059501 - Protein glycosylation: The present invention relates to methods for glycosylating a protein in which the protein is modified to include an alkyne and/or an azide group. The invention further relates to a protein glycosylated by these methods.... Agent: Isis Innovation Limited

20110059502 - Multiple domain proteins: Described herein are methods and compositions for generating and using fusion proteins.... Agent:

20110059503 - Compositions of variant biocatalysts for preparing enantiopure amino acids: A composition of variant biocatalysts, specifically variants of D-amino acid oxidases, with improved biocatalytic activity towards D-amino acid substrates such as, but not limited to, D-tert-leucine, D-norvaline, D-2-aminobutyrate, D-alanine, D-isoleucine, D-valine, D-methionine, D-hydroxyadamantlyglycine, D-penicillamine, or D-norleucine is disclosed. Further disclosed is a method of preparing enantioselective amino acids using variant... Agent: Richmond Chemical Corporation

20110059504 - Engineered transglutaminase barrel proteins: Disclosed herein are methods and compositions related to engineered fragments of the human transglutaminase-related protein family, described herein as engineered transglutaminase barrel proteins (ETBPs), that have utility as high affinity, high selectivity target-binding proteins offering advantages as antibody equivalents for therapeutic, analytical, manufacturing and research purposes. ETBPs differ from naturally... Agent:

20110059505 - Polymerases for nucleotide analogue incorporation: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as... Agent: Pacific Biosciences Of California, Inc.

20110059506 - Recombinase polymerase amplification: This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring... Agent: Alere San Diego, Inc.

20110059507 - Regulatable growth of filamentous fungi: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal... Agent:

20110059508 - Improving agent for dysfunction due to neuropathy and rho kinase activation inhibitor: An object of the present invention is to provide a substance which is able to be an active ingredient for the improvement of dysfunction caused by nerve damage. An improving agent for dysfunction due to nerve damage of the present invention as a means for resolution thereof is characterized in... Agent: Seikagaku Corporation

20110059509 - Polypeptides having xylanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20110059510 - Transgenic rabbits producing human factor vii: The invention relates to transgenic rabbits that produce human factor VII in their mammary glands. The milk of said transgenic rabbits can be used as a raw material for the production of recombinant human factor VII.... Agent:

20110059511 - Subtilases: The present invention relates to novel subtilases from wild-type strains of Bacillus, especially the Bacillus strains ZI344, EP655, P203, EP63, ZI120, ZI130, ZI1342 and ZI140, and to methods of construction and production of these proteases. Further, the present invention relates to use of the claimed subtilases in detergents, such as... Agent: Novozymes A/s

20110059513 - Efficient cell culture system for hepatitis c virus genotype 1a and 1b: The present inventors developed hepatitis C virus 1a/2a and 1b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and NS2 were replaced by the corresponding genes of the genotype Ia reference strain H77C or TN or the corresponding genes of the genotype Ib reference strain... Agent: Hvidovre Hospital

20110059512 - Efficient cell culture system for hepatitis c virus genotype 6a: The present inventors developed hepatitis C virus 6a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 6a reference strain HK6a. Sequence analysis of recovered 6a/2a recombinants from 2 transfection experiments and subsequent... Agent:

20110059515 - Production of isoprenoids: The invention provides a biological method of producing isoprenoids.... Agent:

20110059516 - Production of isoprenoids: The invention provides a biological method of producing isoprenoids.... Agent:

20110059514 - Yeast biocatalysts for degradation of biowarfare agents: The present disclosure relates to yeast biocatalysts and methods of using yeast biocatalysts for detoxifying a biowarfare agent. In some embodiments, a yeast biocatalyst may include a nucleic acid encoding a phage lysin operably linked to a prepro leader sequence, an expression control sequence operably linked to the nucleic acid,... Agent:

20110059517 - Protease variants active over a broad temperature range: The present invention provides protease compositions particularly suited for dishwashing applications.... Agent:

20110059518 - Vertical garden panel: Embodiments of the invention provide a planter system for supporting living plants on a vertical surface that includes a fabric folded into one or more vertically-arranged knife pleats; the pleats are secured and horizontally segmented into vertically arranged, upward facing pockets by a securing mechanism. The upward facing pockets are... Agent:

20110059519 - Automatic system of isolating and incubating circulating tumor cells: The present invention is apllied in fields like biological medicine and tissue engineering. A fluid control system in a cell isolation and culture system is used to automatically process sample preparation, circulating tumor cell (CTC) isolation, plate changing and cell culturing. By using the present invention, time and labor are... Agent: Fooyin University Hospita

20110059520 - Deoxyribonucleic acid measuring apparatus and method of measuring deoxyribonucleic acid: With an insulated gate field effect transistor in which deoxyribonucleic acid (DNA) probes are immobilized on a gold electrode, extension reaction on the gold electrode is performed with DNA polymerase to directly measure an increased amount of a phosphate group caused by the extension reaction, that is, negative charge, by... Agent: Hitachi, Ltd.

20110059521 - Device and method for monitoring inhibition of platelet function: The invention provides a method of monitoring the response of platelets to a cyclooxygenase-1 (COX1) inhibitor such as aspirin. The method involves collecting platelet-containing mammalian blood treated with a COX1 inhibitor; mixing the blood with a COX1-dependent platelet agonist, such as arachidonic acid, monitoring extracellular ATP in the agonist-activated blood... Agent: Medical Innovations International, Inc.

20110059523 - Heat transfer baffle system and uses thereof: This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising two sub-assemblies adjoined to one another is provided.... Agent: Abec, Inc.

20110059522 - Nucleic acids encoding a house dust mite allergen, der p iii, and uses thereof: Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of... Agent: Merck Patent Gmbh

20110059524 - Human cdr-grafted antibody and antibody fragment thereof: A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4... Agent: Kyowa Hakko Kirin Co., Ltd.

20110059525 - Novel ecdysone receptor-based inducible gene expression system: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large... Agent: Intrexon Corporation

20110059526 - Reprogramming a cell by inducing a pluripotent gene through use of an hdac modulator: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises inhibiting the activity of... Agent: Nupotential, Inc.

20110059527 - Active cell culture via shape memory: Substrates for cell culture and tissue engineering bioreactors consisting of polymers that change their shape over time under stimulation by temperature change, hydration, degradation, or other means. A method of controlling cell culture using a biodegradable shape memory polymer, wherein shape changes can transfer stresses, strains, or both to adherent... Agent: Syracuse University

20110059528 - Method for preparing raw pollen: The present invention relates to a method for preparing raw pollen which is suitable for being used for the preparation of allergen extracts. The method involves instantaneously freezing the pollen immediately after harvesting, optionally followed by drying the frozen pollen by sublimation.... Agent:

20110059529 - Methods for genetic plant transformation using water-soluble fullerene derivatives: In various embodiments, methods described herein comprise the use of water-soluble cationic fullerene derivatives for improving plant genetic transformation. Cationic Fullerene derivatives of the invention possess DNA binding and compaction activity and provide a new method to deliver DNA into plant cells for plant transformation. Water-soluble fullerene derivatives of the... Agent:

20110059530 - Novel ecdysone receptor-based inducible gene expression system: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large... Agent: Intrexon Corporation

20110059531 - Method for expression of small rna molecules within a cell: The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, which are capable... Agent: California Institute Of Technology

  
03/03/2011 > 138 patent applications in 66 patent subcategories. listing by industry category

20110053137 - Methods of modulating cold sensory perception: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods... Agent:

20110053142 - Binding protein and epitope-blocking elisa for the universal detection of h5-subtype influenza viruses: Monoclonal antibodies and related binding proteins specific to influenza H5 subtype HA protein can be used in serological diagnosis of influenza H5 infection in mammalian and avian serum samples, including human serum samples. Each antibody reacts strongly with a wide variety of strains of H5 subtype and does not show... Agent:

20110053139 - Detection of bioagents using a shear horizontal surface acoustic wave biosensor: Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other... Agent:

20110053143 - Methods and kits for determining viral load in clinical samples: Methods and kits for determining load of an infectious agent in a sample are described, comprising performing at least one hybridization assay and calculating the load of the infectious agent in the sample from a detected nucleic acid. In particular, the methods and kits disclosed determine the load of human... Agent:

20110053140 - Methods and reagents for diagnosing hantavirus infection: Novel methods and immunodiagnostic test kits for the detection of hantavirus infection are disclosed. The methods and kits employ combinations of recombinant N and/or G1 antigens from at least six different hantavirus serotypes, including Hantann (HTNV), Puumala (PUUV), Seoul (SEOV), Dobrava (DOBV), Sin Nombre (SNV) and Andes (ANDV). Additional hantavirus... Agent:

20110053141 - Methods for ultrasensitive detection and quantification of mutant hepatitis b viruses: This invention provides compositions and methods for ultrasensitive detection and quantification of mutant hepatitis B viruses (HBV). The compositions and methods of the invention can be used to detect HBV mutations for diagnostic and prognostic purposes. This invention also provides new application of a TaqMan hydrolysis probe in asymmetric real... Agent:

20110053144 - Process and system for detecting and/or quantifying bacteriophages capable of infecting a predetermined bacterial host strain, use of a microelectronic sensor device for detecting said bacteriophages and microelectronic sensor for carrying out said proces: The process, system and device being claimed are based on the measurement of the changes in impedance produced in the interface of an electrode whereonto bacteria from a host strain have been previously adhered for detecting the desired bacteriophage. The changes produced in said electrode-bacteria interface originate in the phagic... Agent:

20110053145 - Quantitation method of virus: The present invention relates to a method of quantitatively determining the number of human herpesvirus (HHV) collected from a body fluid and a kit for performing the method. Conventionally, a trained technician has been required to accurately quantitatively determine a number of HHV collected from a body fluid. The method... Agent:

20110053138 - Universal multi-variant detection system: The present invention provides a method to diagnostically detect the variants of a given pathogen, such as HIV, hepatitis C, hepatitis B (HBV), Parvovirus B19, etc., with the use of a single detection probe.... Agent:

20110053154 - 2'-nitrobenzyl-modified ribonucleotides: This disclosure provides novel reversibly terminated ribonucleotides which can be used as a reagent for DNA sequencing reactions. Methods of sequencing nucleic acids using the disclosed nucleotides are also provided.... Agent:

20110053163 - Biomarker: i

20110053165 - Cacnb2 nucleic acid mutations as indicators of shorter than normal qt interval and st segment elevation associated with sudden cardiac death: Previously unknown mutations of the CACNA1C and CACNB2b genes are disclosed which are involved in ion channel disruptions associated with shorter than normal QT interval and ST segment elevation syndrome. These mutations are utilized to diagnose and screen for shorter than normal QT interval and ST segment elevation syndrome, thus... Agent:

20110053148 - Coccidiosis vaccines: The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers comprising such DNA-fragments or recombinant DNA molecules and host cells comprising such DNA-fragments, recombinant DNA molecules or live recombinant carriers. Furthermore, the invention relates to antibodies against the polypeptides... Agent:

20110053146 - Compounds and methods for detecting ricin and uses thereof: This application provides fluorescent probes, substrates, kits and methods for detecting the presence or absence of an enzyme, such as ricin, that catalyzes the release of adenine from a GAGA RNA tetraloop.... Agent:

20110053153 - Dna glycosylase/lyase and ap endonuclease substrates: A new class of nucleic acid substrates for AP endonucleases and members of the glycosylase/lyase family of enzymes is described. Representatives of each family, the enzymes Nfo and fpg, respectively, cleave nucleic acid backbones at positions in which a base has been replaced by a linker to which a variety... Agent:

20110053167 - Gene signatures: The present invention relates generally to a new cluster of correlating molecules in a tissue or at least one cell of a tissue for instance a cell of a blood tissue, preferably such myeloid cells and of identifying the condition of the genes expression said correlating molecules or of the... Agent:

20110053159 - Genetic markers for assessing risk of premature birth resulting from preterm premature rupture membranes: A method to identify women who are at risk for preterm delivery due to premature rupture of membranes (PPROM) is provided. The method entails detecting the presence of SERPINH1 gene variants that express low levels of the gene product, heat shock protein Hsp47. The occurrence of a T (rather than... Agent:

20110053160 - Hcv ns3/4a replicon shuttle vectors: The present invention provides for novel HCV NS3/4A replicon shuttle vectors useful for cloning in HCV polynucleotide sequences from samples of HCV-infected patients and testing the resulting replicons for drug susceptibility.... Agent:

20110053147 - Heat-resistant dna ligase with high reactivity: Thermostable DNA ligases with enhanced DNA binding activity and reaction activity are obtained. These modified thermostable DNA ligases having enhanced DNA binding activity compared to the wild type can be obtained by substituting a negatively charged amino acid (for example, the amino acid corresponding to the aspartic acid at position... Agent:

20110053170 - Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease: The present invention includes methods for the use of interleukin-33 (IL-33) in the diagnosis of cardiovascular conditions including acute coronary syndrome (ACS), myocardial infarction, and/or heart failure, angina, cardiac hypertrophy, arteriosclerosis, myocarditis, pericarditis, endocarditis, stroke and/or pulmonary embolism and the determination of the severity of such conditions (prognosis).... Agent:

20110053150 - Method and kit for detection/quantification of target rna: [Solving Means] The method comprises the steps of 1) synthesizing cDNA from a sample containing the target RNA using a liquid-phase primer having a promoter sequence and a reverse transcriptase to obtain a cDNA-RNA complex, 2) degrading the RNA of the complex, 3) synthesizing a double-stranded DNA via the cDNA... Agent:

20110053152 - Method for cancer detection, diagnosis and prognosis: The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC), for example, a viable CTC, from a sample using a parylene microfilter device comprising a membrane filter having or consisting... Agent:

20110053169 - Method for continuous mode processing of the contents of multiple reaction receptacles in a real-time amplification assay: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a... Agent:

20110053164 - Methods for determining cancer resistance to histone deacetylase inhibitors: Described herein are methods and compositions for determining whether a particular cancer is resistant to or susceptible to a histone deacetylase inhibitor or to histone deacetylase inhibitors. The methods include analysis of the expression levels of at least four biomarker genes associated with response to a histone deacetylase inhibitor. Also... Agent:

20110053149 - Methylation detection in the genomic region of a receptor proteintyrosine phosphatase gamma gene for detection and/or diagnosis of a tumour: The invention discloses means and methods for detecting methylation of a CpG in a region of a receptor protein tyrosine phosphatase gamma gene in samples obtained from a relevant site of an individual. The means and methods can be used to determine whether the individual is suffering from a tumor.... Agent:

20110053151 - Microfluidic device and method of using same: A microfluidic device comprising a plurality of reaction chambers in fluid communication with a flow channel formed in an elastomeric substrate, a vapor barrier for preventing evaporation from the plurality of reaction chambers, and a continuous phase fluid for isolation of each of the plurality of reaction chambers.... Agent:

20110053158 - Mirna biomarkers of lung disease: This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing lung disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as lung cancer.... Agent:

20110053155 - Polar dyes: The present invention relates to novel polar fluorescent and quenchers dyes, and minor groove binder with enhanced polarity. The present invention further relates to methods of preparing oligonucleotide probes labeled with polar arsonate dyes under the condition of automated synthesis and method of using such probes.... Agent:

20110053162 - Reactive cyanine compounds: The invention provides compounds and compositions of Formulas I-VII, and methods of using the compounds. The compounds can be used to prepare dye conjugates that are uniformly and substantially more fluorescent on proteins, nucleic acids or other biopolymers, than conjugates labeled with structurally similar known carbocyanine dyes. In addition to... Agent:

20110053168 - Reagent comprising primer for detection of mrna for cytokeratin-7: Disclosed is a primer for detecting mRNA for CK7. The primer comprises a first sequence on its 5′-terminal side and a second sequence on its 3′-terminal side. The first sequence has a length of 10 to 30 nucleotides, and can hybridize with a strand complementary to a first region which... Agent:

20110053161 - Sequential sampling for unexpected damage to bt corn for corn rootworm control: Methods are provided for the sequential sampling of pest resistant crop plants for determining resistance of a pest to a pesticidal activity of a pest resistant crop plant. The methods involve choosing a plant in a plot in an unbiased sampling manner. Trait expression is determined for each of the... Agent:

20110053156 - Small cell lung carcinoma biomarker panel: The invention relates generally to the field of cancer detection, diagnosis, subtyping, staging, prognosis, treatment and prevention. More particularly, the present invention relates to methods for the detection, and/or diagnosing and/or subtyping and/or staging of lung cancer in a patient. Based on a particular panel of biomarkers, the present invention... Agent:

20110053166 - Stem cell expression cassettes: A stem cell expression cassette, comprising a nucleic acid comprising a pluripotent stem cell specific promoter, and a tag sequence, wherein the pluripotent stem cell specific promoter and tag sequences are operatively linked, is provided. Also provided are methods of identifying and methods of selecting a pluripotent cell, using the... Agent:

20110053157 - Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions: The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a′ subject by detecting a biomarker in microvesicles isolated from a biological, sample from the subject. Moreover, disclosed subject matter is directed to methods of diagnosis,... Agent:

20110053175 - Asymmetrically branched polymer conjugates and microarray assays: A composition comprising a conjugate of a randomly and asymmetrically branched dendritic polymer.... Agent:

20110053173 - Game with detection capability: Methods and systems are described herein relating to game systems. In one aspect, a game system includes: at least one game component configured for use in a game system by an individual player; at least one sensor system operably connected to the at least one game component and configured to... Agent:

20110053174 - Magnetic-nanoparticle conjugates and methods of use: The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked... Agent:

20110053177 - Mass spectrometric methods and products: The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.... Agent:

20110053171 - Method and apparatus for antigen retrieval process: The invention provides a method for antigen retrieval of a formaldehyde-fixed tissue sample comprising incubating a formaldehyde-fixed tissue sample in a first antigen retrieval solution at a temperature of greater than 90° C., transferring the tissue sample to a second antigen retrieval solution, and incubating the tissue sample in the... Agent:

20110053172 - One step nanosensor for single and multidrug resistance in acute coronary syndrome (acs): An embodiment relates to a method of detecting a drug resistance in a patient comprising adding nanoparticles to sample platelets to form activated platelets containing the nanoparticles and comparing a difference in activation of the activated platelets and the sample platelets. Another embodiment relates to a method of monitoring a... Agent:

20110053176 - Particle suspension and reagent kit for use in immunoassay: A particle suspension for use in immunoassay, comprising: particles for use in immunoassay; and a silicone antifoam agent, is disclosed. And a reagent kit for use in immunoassay, comprising: a reagent containing particles and a silicone antifoam agent; another reagent containing an antigen or antibody capable of binding to a... Agent:

20110053182 - Diagnosis of pre-cancerous conditions using pcdgf agents: The present invention relates to methods and compositions designed for the treatment or management of pre-cancerous conditions, especially in order to prevent, delay, or decrease the likelihood that the pre-cancerous condition will progress to malignant cancer. The methods of the invention comprise the administration of an effective amount of one... Agent:

20110053183 - Method of concentrating human mesenchymal stem cells: The present invention is intended to provide methods for highly enriching human mesenchymal stem cells from a cell population containing the human mesenchymal stem cells. To highly enrich human mesenchymal stem cells, CD271+CD90+ cells are recovered by using flow cytometry etc. from a cell population containing the human mesenchymal stem... Agent:

20110053184 - Nucleic acid encoding a haplotype of human t2r receptor ht2r50: The present invention relates to the discovery of a novel haplotype of the human taste receptor hT2R50 in the T2R taste receptor family that responds to particular bitter ligands, i.e., 2-acetylpyrazine and ethylpyrazine. The present invention also relates to the use of this novel haplotype in assays for identifying ligands... Agent:

20110053185 - Culture based screening assay and methods of use thereof to identify agents which modulate tumor development, invasion and differentiation: A 3D organotypic culture which phenocopies aggressive, invasive cancer and methods of use thereof are provided.... Agent:

20110053186 - Chlorite in the treatment of neurodegenerative disease: The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood... Agent:

20110053187 - Silica-based material for detection and isolation of chitin and chitin-containing microorganisms: The subject invention provides silica-based material that has high affinity to chitin, chitin derivatives and chitin-containing microorganisms at an acidic pH. In an embodiment, the silica-based material surface comprises glass. Also provided are methods for preparing the subject silica-based chitin-binding material. In addition, the subject invention provides rapid, specific, sensitive,... Agent:

20110053179 - Biomarkers for prediction of major adverse cardiac events and uses thereof: The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac event (MACE) in a patient.... Agent:

20110053180 - Kinase sensors: The present invention generally relates to compositions and methods for determining kinase activity. In some cases, the compositions comprise a triazole heterocycle. In some embodiments, the compositions comprise a quinoline moiety. In one aspect, the present invention is directed to compositions that undergo chelation-enhanced fluorescence (CHEF). In some cases, the... Agent:

20110053178 - Methods and compositions for detection of lethal cell and uses thereof: The present invention relates to methods and compositions for identifying and detecting lethal cell useful for monitoring disease status and therapy response in various types of cancer patients regardless of the etiological origin of the cancer and uses thereof.... Agent:

20110053181 - Method for detecting objective substance and kit for detecting objective substance: A method for detecting an objective substance in a sample using a chromatographic test device having a detection region on which a capture substance capable of binding to the objective substance is immobilized, comprising: mixing the sample and an enzyme-labeled substance capable of binding to the objective substance; trapping the... Agent:

20110053188 - Endotoxin detection method: The invention relates to a method for detecting endotoxins in a sample.... Agent:

20110053191 - Method for risk reduction in glycemic control: Disclosed is a method for identifying a subject being susceptible to a therapy for intensive glycemic control, the subject suffering from diabetes and being in need for a therapy for intensive glycemic control, based on determining the amount of PLGF (placental growth factor) in a sample of the subject and... Agent:

20110053189 - Type iv secretion system proteins in sero-detection of anaplasma phagocytophium: Disclosed are two (2) proteins in the Type IV Secretion System (TIVSS) in Anaplasma phagocytophilum (namely, virB 10 and virB11) useful in the ELISA detection of Anaplasma pathogen. The recombinant expression of virB 10 and virB 11 and their use as kits for ELISA are also disclosed.... Agent:

20110053190 - Use of cfh or apoh as a biochemical diagnostic marker for complete remission in acute myeloid leukemia: The present invention relates to a diagnostic method for acute myeloid leukemia, in particular, a method for using CFH or ApoH in patient sera as biochemical diagnostic markers to determine complete remission in acute myeloid leukemia. In accordance with this invention, CFH and ApoH are identified as a novel biochemical... Agent:

20110053192 - Method of rapid detection of an analyte in bodily fluids using a fluorescent dry test strip biosensor: Disclosed herein is a dry fluorescence biosensor strip for rapid detection of a target analyte present in bodily fluids. The dry fluorescence biosensor strip comprises a sample receptacle and a dry detection membrane. The sample receptacle receives a sample of one of the bodily fluids. The dry detection membrane detects... Agent:

20110053193 - Protein assay: A method is described for the measurement of thrombin activity in the presence of fibrinogen, or for the measurement of the functionality of fibrinogen in the presence of thrombin.... Agent:

20110053194 - Transformant transfected with flavin adenine dinucleotide-binding glucose dehydrogenase gene and method for producing flavin adenine dinucleotide-binding glucose dehydrogenase using the same: It is intended to highly efficiently produce a large amount of novel FAD-GDH capable of more accurately measuring a glucose level. Provided is a transformant in which a DNA encoding a flavin adenine dinucleotide-binding glucose dehydrogenase selected from the group consisting of (a) a DNA encoding the amino acid sequence... Agent:

20110053195 - Catalytically inactive proteins and method for recovery of enzymes from plant-derived materials: An inactive xylanase molecule for the recovery of xylanase activity in plant-derived material containing active xylanase enzyme(s) and xylanase inhibitors. The inactive xylanase molecule of binds to xylanase inhibitors in the plant-derived material, thereby allowing accurate measurement of xylanase enzyme activity of the enzyme contained in the plant-derived material. The... Agent:

20110053196 - Method for modifying a peptide and a method for identifying a peptide:

20110053197 - Ubiquitin proteasome system profiling and the use thereof in clinical applications for cancer diagnosis: Provided herein are methods for the diagnosis, prognosis, or management of neoplastic diseases, i.e. cancer, and other diseases using profiles of the ubiquitin-proteasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of cancer patients.... Agent:

20110053199 - Ubiquitin proteasome system profiling and the use thereof in clinical applications for cancer diagnosis: Provided herein are methods for the diagnosis, prognosis, or management of neoplastic diseases, i.e. cancer, and other diseases using profiles of the ubiquitin-protcasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of cancer patients.... Agent:

20110053198 - Ubiquitin proteasome system profiling and the use thereof in clinical applications for proliferative hematological disorders: Provided herein are methods for the diagnosis, prognosis, or management of proliferative hematological disorders and other diseases using profiles of the ubiquitin-proteasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of leukemia patients.... Agent:

20110053200 - Method for increasing light emission from a chemiluminescent reaction: Method for increasing the emission of light from a chemiluminescent reaction including luminol, a peroxidase enzyme, an oxidant and a mediator of electrons through the use of a hypernucleophilic acylation catalyst belonging to the class of 4-aminopyridines. It is also described the use in diagnostic assays of chemiluminescent substrates containing... Agent:

20110053202 - Analytical system, analytical method and flow-path structure: An analytical system for performing centrifugal analysis on a working fluid with different components includes a uniform-dividing unit with a reduced cross section to divide the working fluid, a separating unit connected to the uniform-dividing unit, and a detecting unit. The detecting unit includes a detection compartment and a constant-quantity... Agent:

20110053208 - Biological sample identification system: The present invention contemplates a handling device for a biological specimen. The handling device includes a substrate with at least one crease that divides the substrate into a handle portion and a receiving portion that includes an aperture having a perimeter that is configured so that it receives a container... Agent:

20110053205 - Composition and methods for expressing reporter molecules in mammalian cells: Disclosed herein is a novel system and methods for expressing exogenous genes, such as genes encoding fluorescent proteins, in mammalian cells. In one embodiment of this system and methods, a gene essential for viral infectivity or replication in cell culture is deleted or inactivated in the genome of a non-mammalian... Agent:

20110053203 - Copolymer assay: The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.... Agent:

20110053201 - Method of cell separation: (vi) detecting the composition of the transported blood component by the first sensor (25). The second sensor (85) also detects the composition of the transported blood component after the first sensor (25) has output a signal corresponding to a predetermined composition of the blood component. The transporting and the spinning... Agent:

20110053206 - Method of using ligand-free lysing agent in hemoglobin analysis: Lysing agents that are free of ligands, including cyanide, for binding hemoglobin for hematology analyzers. The ligand-free lysing agents achieve accurate quantification of hemoglobin parameters, thereby replacing existing lysing agents for analysis of hemoglobin.... Agent:

20110053207 - System and method for in vitro blood vessel modeling: The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on... Agent:

20110053204 - Use of an adaptive chemically reactive plasma for production of microbial derived materials: A relatively lower value carbonaceous feedstock can be converted into a relatively higher value chemical product, by introducing the relatively lower value carbonaceous feedstock into an inductively coupled plasma (ICP) torch under conditions selected to generate a synthetic gas mixture having a tailored composition, and then introducing the synthetic gas... Agent:

20110053209 - Use of an immunoregulatory nk cell population for monitoring the efficacy of anti-il-2r antibodies in multiple sclerosis patients: The use of CD56bright NK cell counts as a biomarker for the efficacy of anti-IL-2R antibody treatment in patients diagnosed with multiple sclerosis.... Agent:

20110053210 - Blood analyzer, blood analysis method and hemolytic agent: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement... Agent:

20110053212 - Blood analyzer, blood analysis method, hemolytic agent and staining agent: This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells... Agent:

20110053211 - Process and device for determining the condition of biological material, in particular food: The invention relates to a process for determining—remotely and without taking samples—the condition of biological material, in particular food, as well as a device for performing this process. Radiation emission is thus induced with coherent beams in the material to be examined and is directly measured, whereby the measured values... Agent:

20110053213 - Polypeptides having ferulic acid esterase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having ferulic acid esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent:

20110053215 - Endoglycosidases that cleave o-linked glycans: Methods and compositions have been described that relate to a newly identified polypeptide family wherein each member has O-glycosidase activity and specified sequence characteristics. This family of enzymes can be used for example for cleaving O-linked glycans and for synthesis of neoglycopeptides or neoglycoproteins.... Agent:

20110053214 - Production of galactosylated glycoproteins in lower eukaryotes: The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal β-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in... Agent:

20110053219 - Method for the targeted integration of multiple copies of a gene of interest in a yarrowia strain: This invention concerns a method for the targeted integration of at least three copies of a gene of interest in the genome of a Yarrowia strain including the steps of: (a) cultivating a Yarrowia strain, said strain including a deletion among at least three genes, the phenotype associated with each... Agent:

20110053216 - Modified cyanobacteria: Disclosed is a modified photoautotrophic bacterium comprising genes of interest that are modified in terms of their expression and/or coding region sequence, wherein modification of the genes of interest increases production of a desired product in the bacterium relative to the amount of the desired product production in a photoautotrophic... Agent:

20110053218 - Multiple promoter platform for protein production: A multiple promoter platform for expression of a protein or multiple and different proteins in a microorganism comprising two or more expression vectors having a nucleic acid molecule encoding a protein to be expressed, or having different nucleic acid molecules encoding different proteins to be expressed, wherein each vector has... Agent:

20110053220 - Novel protein capable of binding to hyaluronic acid, and method for measurement of hyaluronic acid using the same: The present invention relates to a polynucleotide encoding a protein comprising an amino acid sequence shown in SEQ ID NO: 2, wherein the protein encoded by the polynucleotide has a hyaluronic acid binding ability, the protein, a method for measuring hyaluronic acid using the protein, and a reagent kit for... Agent:

20110053217 - Polynucleotides encoding signal peptide-containing molecules: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.... Agent:

20110053221 - Recombinant production of authentic human proteins using human cell expression systems: The present invention relates to novel expression cassettes and vectors for efficiently producing authentic recombinant human proteins from stable cultures of novel human cell lines, the authentic recombinant proteins produced therefrom, and antibodies raised against those authentic recombinant proteins.... Agent:

20110053223 - Cell culture methods to make antibodies with enhanced adcc function: The present invention concerns antibodies with enhanced antibody-dependent cell mediated cytotoxicity (ADCC) and method for preparation thereof.... Agent:

20110053222 - Pc5 as a factor ix propeptide processing enzyme: Compositions and methods for preparing Factor IX, Factor IX-containing fusion proteins, and Factor IX-containing conjugates with processing of Factor IX propeptide by PCS, are provided. In one embodiment PCS is used to process a precursor polypeptide for a Factor IX-Fc monomer-dimer hybrid.... Agent:

20110053224 - Novel composition of matter and method for stimulating the growth of beneficial microorganisms: The invention describes a novel composition of matter obtained from the leaves of green plants, which is useful in promoting the growth of beneficial microorganisms. Specifically, that the invention describes a hydrolysate prepared from plant leaf biomass (leaf biomass hydrolysate or ‘LBH’) which dramatically stimulates the growth of beneficial microorganisms.... Agent:

20110053225 - Multifunctional tags: The present invention relates to multifunctional protein production tags comprising at least 4, preferably 4-8 amino acids, for optimising expression of proteins and purification thereof by various multi-step processes including chromatographic or filtration, as well as batch unit operations. The tags include sequences of multiple defined purposes which are not... Agent:

20110053226 - Method for enzymatic synthesis of chemically modified rna: The present invention relates to a method for enzymatically synthesizing chemically modified RNA by using RNA-dependent RNA polymerases (RdRp), especially RdRps from viruses of the Caliciviridae family. The method of the present invention is particularly useful for preparing RNA molecules of increased stability especially with respect to RNA degradation, for... Agent:

20110053227 - Process for preparing l-amino acids using improved strains of the enterobacteriaceae family: e

20110053228 - Microbial processing of cellulosic feedstocks for fuel: A system and method are provided which utilize microbes to convert biomass feedstock into a fuel. In one aspect, a method of producing aromatic compounds and lipids includes: receiving a feedstock including biological matter; separating the feedstock into a liquid phase feedstock and a solid phase feedstock; adding water and... Agent:

20110053229 - Method for production of immobilized enzyme: The method of producing an immobilized lipolytic enzyme includes: mixing an immobilized lipolytic enzyme that has been used in an esterification reaction with a solvent to wash the immobilized lipolytic enzyme so that the residual oil content in the immobilized lipolytic enzyme is reduced to 50 parts by mass or... Agent:

20110053230 - Method for controlling rate of lowering molecular weight of polysaccharides contained in cellulosic biomass, and method for producing sugar, alcohol, or organic acid: An object of the present invention is to provide, with regard to a method for lowering the molecular weight of polysaccharides contained in a cellulosic biomass by mixing the cellulosic biomass with ionic liquid, a method for controlling such rate of lowering of molecular weight. Also, a method for producing... Agent:

20110053231 - Method of producing lactic acid by continuous fermentation: A method of producing lactic acid continuous fermentation including filtering a culture of polyploid yeast having a capacity to produce lactic acid through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm, and recovering the product from the filtrate while... Agent:

20110053232 - Producing itaconic acid in yeast using glycerol as the substrate: Method for producing itaconic acid in yeast cells using glycerol as the substrate. The yeast cells express cis-aconitic acid decarboxylase and optionally, citrate synthase and/or aconitase at high levels.... Agent:

20110053233 - Methods for improving malic acid production in filamentous fungi: The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous... Agent:

20110053234 - Production method for biomass alcohol: The production method for biomass-alcohol comprises saccharification step to saccharify biomass, first concentrating step including to atomize for ultrasonically vibrating the saccharified solution and atomizing the saccharified solution into mist, and to elevate the sugar concentration in the saccharified solution by removing water from the saccharified solution, fermentation step for... Agent:

20110053235 - Fermentative production of isobutanol with yeast: The invention relates to a yeast cell producing isobutanol, characterized in that the cell has an increased metabolic flow of material from pyruvate and acetolactate, 2,3-dihydroxy isovalerate, 2-ketoisovalerate, isobutyraldehyde to isobutanol, in that at least one of the genes coding the enzymes, which are involved in this conversion, is over-expressed,... Agent:

20110053236 - Ethanol production: A method for increasing production of ethanol in an ethanologenic cell using an autoinducer molecule, for example AI-2.... Agent:

20110053237 - Producing fermentation products in the presence of aldehyde dehydrogenase: The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or more aldehyde dehydrogenases are present in the fermentation medium.... Agent:

20110053238 - Method of production of ethanol from two different starting materials: The present invention provides a method of improving the ethanol yield in production of an ethanol-containing product from a lignocellulosic biomass and a sugar product containing fermentable sugars derived from a sugar-rich material. The method comprises treatment, involving hydrolysis, of said lignocellulosic biomass in one or more steps to obtain... Agent:

20110053239 - Methods: A method of pre-treating lignocellulosic and cellulosic biomass for utilization of carbohydrate or lignin from the biomass, the method comprising the steps of inoculating the lignocellulosic biomass with lignocellulose degrading brown rot fungus and incubating the inoculated biomass under conditions in which growth of the lignocellulose degrading brown rot is... Agent:

20110053241 - Device and method for mechanically deforming cells: The present invention relates to a device for mechanically deforming cells comprising: a cell holding element (33) for holding a cell (32) in a cell holding zone, a micro-actuator (31) for applying a force on the held cell (32), wherein said micro-actuator (31) can be electrically, thermally, photonically or magnetically... Agent:

20110053240 - Dna damaging agents in combination with tyrosine kinase inhibitors: The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.... Agent:

20110053242 - Immunoaffinity isolation of modified peptides from complex mixtures: The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized... Agent:

20110053243 - Asymmetrically branched polymer conjugates and microarray assays: A conjugate of a randomly and asymmetrically branched dendritic polymer and a member of a binding pair.... Agent:

20110053244 - Novel protein delivery system to generate induced pluripotent stem (ips) cells or tissue-specific cells: A novel protein delivery system to generate induced pluripotent stem (iPS) cells is described. The delivery system comprises a construct with a receptor binding domain that recognizes a receptor in a somatic cell, a translocation domain that allows the transfer of an inducer into the cytosolic space, and a cargo... Agent:

20110053245 - Isomerases, nucleic acids encoding them and methods for making and using them: This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-, arrangement of atoms within a molecule, catalyze... Agent:

20110053246 - Overexpression of phytase genes in yeast systems: The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a heterologous phytase and the vectors used to produce the phytase are also... Agent:

20110053247 - Large-scale production of soluble hyaluronidase: Provided are methods for preparing large-scale preparations of soluble hyaluronidases. The methods employ cells that contain a plurality of active copies of nucleic acid encoding the soluble hyaluronidase and a plurality of feedings and temperature changes, whereby the encoded soluble hyaluronidase is secreted into the cell culture medium.... Agent:

20110053248 - serum-free virus propagation platform for a virus vaccine candidate: The invention relates to methods for propagating viruses. In particular, the invention provides optimized conditions for propagating viruses. Optimization of the following parameters are provided: lipid concentrates as supplements to the medium, temperature shift from pre-infection to post-infection, multiplicity of infection, direct bead-to-bead transfer and serum supplementation of pre-infection medium.... Agent:

20110053249 - Adenoviruses mutated in the va genes for cancer treatment: This invention refers to the use of an adenovirus for cancer treatment, being this adenovirus defective in its virus-associated (VA) RNAs. Said adenovirus has a mutation in the VAI or VAII gene sequence or both. This adenovirus may also have mutations in the sequences controlling expression of the VA RNAs.... Agent:

20110053250 - Enrichment method of virus: The present invention provides a novel method that can increase readily a virus or viral vector concentration in a solution having a low concentration and a kit for performing the method. Conventional methods require complicated operations, expensive equipment, or highly trained experts for efficiently concentrating viruses from low-concentration virus solutions.... Agent:

20110053251 - Reagents for lysis of bacterial cells: The invention provides a composition containing an aqueous liquid phase, bacterial cells, and an ionic compound dissolved in the liquid phase. The ionic compound is selected from the group consisting of 1-butyl-3-methyl-imidazolium-thiocyanate, 1-butyl-3-methyl-imidazolium-2(2-methoxy-ethoxy)ethylsulfate, 1-methyl-1-[4-(3-methyl-3H-imidazol-1-ium)-but-1-yl]-3H-imidazolium-di(toluylsulfate), and 1-butyl-3-methyl-imidazolium-octylsulfate. The compositions of the invention are advantageously used for preparing lysates of biological cells,... Agent:

20110053254 - Materials and methods relating to modifying the binding of antibodies: The invention relates to materials and methods for modifying the binding of antibodies, and more particularly to antibodies that are obtainable by inserting an amino acid sequence capable of binding to a target into a complementarity determining region of a parent antibody so that the antibody thus obtained is capable... Agent:

20110053252 - Microorganism producing o-acetyl-homoserine and the method of producing o-acetyl-homoserine using the microorganism: Disclosed herein are a microorganism strain capable of producing the L-methionine precursor O-acetyl homoserine in high yield and a method of producing O-acetyl homoserine using the same. The microorganism strain is a strain of Escherichia sp. in which an acetyl-CoA synthase gene (acs) and/or a pantothenate kinase gene (coA) encoding... Agent:

20110053253 - Microorganism producing o-acetyl-homoserine and the method of producing o-acetyl-homoserine using the microorganism: Disclosed is a strain of Escherichia sp., capable of producing O-acetyl homoserine in high yield, with the introduction and enhancement therein of the activity of: homoserine acetyl transferase, aspartokinase and homoserine dehydrogenase; and at least one enzyme selected from a group consisting of phosphoenolpyruvate carboxylase, aspartate aminotransferase and aspartate semi-aldehyde... Agent:

20110053255 - Deactivating an explosive composition using plants: A method of deactivating an explosive composition provided in an explosive cartridge, which method comprises exposing the explosive composition to a deactivating agent that renders the explosive composition insensitive to detonation, wherein the deactivating agent is a plant.... Agent:

20110053256 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent:

20110053257 - Photo-bioreactor with particle separation and water recovery system: The Photo-bioreactor with Particle Concentration and Water Recovery System is a bioreactor system designed to propagate algae under fully closed, controlled conditions. The system is highly efficient and has a reduced turnaround time compared to similar photo-bioreactors. The system has an integrated, gravity-flow biomass harvest and water recovery system that... Agent:

20110053258 - Novel promoter sequence and the application thereof: The present invention provides a novel promoter sequence derived from a promoter of geminivirus, a eukaryotic virus, and has the characteristics of prokaryotic promoters. The isolated sequence includes SEQ ID NO: 5, which can drive the expression of foreign genes in prokaryotic cells to a high level utilizing the prokaryotic... Agent:

20110053260 - Recombinant poxvirus expressing homologous genes inserted into the poxviral genome: The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use... Agent:

20110053259 - Recombinant poxvirus expressing homologous genes inserted into the poxvirus genome: The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use... Agent:

20110053264 - Framework residue substituted humanized col-1 antibodies and their use: The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal antibodies that have reduced immunogenicity, compared to a parent antibody. The disclosed humanized COL-1 antibodies include substitution of framework residues with residues from the corresponding... Agent:

20110053261 - Methods for determining correlated residues in a protein or other biopolymer using molecular dynamics: The invention provides methods and systems of determining biopolymer profiles and correlations between structural units (residues) of a biopolymer based on sampling of the conformational space available to the molecule. The correlations between these structural units can further be used to find networks within a biopolymer such as the coupled... Agent:

20110053262 - Methods of fabricating enhanced tissue-engineered cartilage: Compositions and methods for fabricating a tissue-engineered cartilage construct comprising: providing a cell sample comprising a plurality of chondrocytes; culturing the cell sample to produce a tissue-engineered cartilage construct; and treating the tissue-engineered cartilage construct, wherein treating the tissue-engineered cartilage construct comprises the use of a biochemical reagent, a mechanical... Agent:

20110053263 - Multipotent cancer stem cell lines and method for producing the same: Provided is a multipotent cancer stem cell line derived from breast-cancer tissue and expressing a breast cancer stem cell marker. Also provided is a method for producing a multipotent cancer stem cell line, including (1) isolation of breast-cancer cells from previously extracted breast cancer tissue, (2) primary culture of the... Agent:

20110053265 - Cell culture performance with betaine: This invention relates generally to the field of cell culture. More particularly, the invention relates to improving viability of recombinant cell cultures and the yields of secreted polypeptides therefrom by the addition of betaine to the tissue culture medium.... Agent:

20110053266 - Methods, kits, and compositions for stem cell self-renewal: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.... Agent:

20110053267 - Method for preparation of platelet from ips cell: The present invention provides a sac-like structure enclosing hematopoietic progenitor cells, which is obtained by inoculating iPS cells onto feeder cells and then culturing the iPS cells under conditions suitable for inducing the differentiation of hematopoietic progenitor cells. Moreover, the present invention also provides a method for producing various types... Agent:

20110053268 - Method for diagnosis of abnormal iron metabolism using active hepcidin as indicator: The present inventor employed surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) to analyze distinctive serum proteomic patterns of hemodialysis patients. The present inventor found three peptides at 2,192, 2,789, and 2,851 m/z that showed a significant correlation with the levels of serum ferritin. The molecular sizes of the 2,192... Agent:

20110053269 - Laminar construct for tissue-engineered dermal equivalent: Compositions and methods for creating a laminar construct for tissue-engineered dermal equivalent are provided. One composition provided herein comprises a hydrogel matrix comprising two or more hydrogels layers and a population of stem cells. Associated methods are also provided.... Agent:

20110053270 - Patterning hydrogels: A method for forming a pattern-coated substrate includes disposing a composition comprising a polysaccharide-based polymer on a substrate to generate a coated substrate. The polysaccharide-based polymer composition is substantially free of cross-linking monomers. The method further includes exposing a portion of the coated substrate to a first dose of UV... Agent:

20110053271 - Irradiation induced grafting of polysaccharides to cell culture vessels: A method for grafting a polysaccharide to a surface of a cell culture article includes (a) contacting the surface of the article with the polysaccharide in a dry form; and (b) exposing the surface of the article and contacted dry polysaccharide to ionizing radiation to graft the polysaccharide to the... Agent:

20110053272 - Methods for cloning and manipulating genomes: Compositions and methods are disclosed herein for cloning a donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed... Agent:

20110053273 - Methods for cloning and manipulating genomes: Compositions and methods are disclosed herein for cloning a synthetic or a semi-synthetic donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a... Agent:

20110053274 - Lac expression system: Provided herein is a nucleic acid comprising a mutant lac operator operably linked to a gene of interest, a host cell comprising the nucleic acid, and a method of using the host cell to express the gene of interest. Also provided is a recA-mediated cloning method.... Agent:

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