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Chemistry: molecular biology and microbiology February patent applications/inventions, industry category 02/11Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 02/24/2011 > patent applications in patent subcategories. patent applications/inventions, industry category
20110045455 - Suspension medium for red blood cells: The present invention relates to a new suspension medium or diluent solution for red blood cells for use in haematological methods. The suspension medium or diluent solution for red blood cells may comprise a combination of two or more amino acids of any group, and preserves the red blood cells... Agent: Leason Ellis LLP
20110045457 - Assays for adsorbed influenza vaccines: Influenza hemagglutinin (HA) binds to aluminium salt adjuvants and cannot easily be directly assayed directly a single radial immunodiffusion (SRID) test. The invention modifies the SRID protocol for an adsorbed antigen by including a step in which antigen is desorbed prior to diffusion.... Agent: Novartis Vaccines And Diagnostics Inc.
20110045456 - Compositions for use in identification of adventitious contaminant viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Casimir Jones, S.c.
20110045458 - Detection of enterovirus: This document describes methods and materials relating to viral diagnostics, and more particularly to the detection of enterovirus. For example, primers and probes for the detection of enterovirus are provided. Articles of manufacture containing such primers and probes for detecting enterovirus are further provided.... Agent: Fish & Richardson P.C. (tc)
20110045485 - Analytical method and kit: RNA-containing probes and kits comprising RNA-containing probes for the detection and analysis of nucleic acid sequences are described. These probes are contacted with a sample suspected of containing the nucleic acid sequence and if they form duplexes, they are hydrolysed. This may be done, for example during an amplification reaction.... Agent: Polsinelli Shughart PC
20110045465 - Cancer screening method: A method for screening cancer comprises the following steps: (1) providing a test specimen; (2) detecting the methylation rate of the CpG sequence in at least one target gene of the test specimen, wherein the target genes is consisted of PTPRR, ZNF582, PDE8B and DBC1; and (3) determining whether there... Agent: Schmeiser Olsen & Watts
20110045474 - Copi molecules and uses thereof: The invention provides diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers. The methods and uses can further include detecting p53 expression. The invention also provides reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding.... Agent: Arnold & Porter LLP (24126) Attn: Sv Docketing Dept.
20110045483 - Diagnostic screens for alzheimer's disease: The present invention relates diagnostic screens for Alzheimer's disease, and in particular to diagnostic tests based on screening for the presence of cellular changes that occur early in the pathology of Alzheimer's disease.... Agent: Edell, Shapiro & Finnan, LLC
20110045462 - Digital analysis of gene expression: The disclosure provides methods and compositions useful for high throughput sequencing of nucleic acid sequences associated with gene expression, nucleic acid-polypeptide interactions, and/or chromosomal interactions.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP
20110045466 - Field-effect transistor type biosensor and bio-signal amplification method thereof: The present invention discloses a field-effect transistor (FET) type biosensor and a bio-signal amplification method. The biosensor comprises a field-effect transistor chip, a biomolecular immobilization layer and at least one primer. The biomolecular immobilization layer is formed on a gate surface of the FET chip or a surface of an... Agent: Wpat, PC Intellectual Property Attorneys
20110045478 - Genetic fingerprinting and identification method: The present disclosure provides methods for molecular fingerprinting for the characterization and identification of organisms. More specifically, in one aspect the present invention provides a method of identifying an organism in a sample comprising: (a) providing a sample comprising said organism, said organism comprising at least one nucleic acid; (b)... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.
20110045477 - Human skin explant culture system and use therefor: The present invention features a human skin explant culture system and uses thereof.... Agent: Philip S. Johnson Johnson & Johnson
20110045476 - Inflammatory bowel disease prognostics: The methods and systems of the present invention are useful in the diagnosis of inflammatory bowel disease (IBD) and in the prognosis of IBD progression and disease complications. With the present invention, it is possible to predict outcome of disease and patients who will have a particular risk of disease... Agent: Townsend And Townsend And Crew, LLP
20110045473 - Liver screening method: The invention features a method of identifying therapeutically relevant compositions that include a therapeutic agent and a delivery component by screening for an effect of the agent on the liver of a model subject.... Agent: Lando & Anastasi, LLP A2038
20110045479 - Method for high resolution melt genotyping: Various methods are described that provide for high resolution melt (HRM) genotyping. The embodiments include providing a locus specific primer and two allele specific primers each having a 5′ end with a short tail, providing a nucleic acid having a single nucleotide polymorphism (SNP) base located within 1-20 base pairs... Agent: Life Technologies Corporation C/o Intellevate
20110045463 - Method for measuring dna methylation: The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on.... Agent: Panitch Schwarze Belisario & Nadel LLP
20110045484 - Method of detecting target molecule by using aptamer: An aptamer-probe complex for detecting the presence of a target molecule is disclosed. The complex of the present invention contains an aptamer moiety which is able to bind to an indicator protein and change the properties of the indicator protein, and a probe moiety which is able to bind to... Agent: Birch Stewart Kolasch & Birch
20110045464 - Methods and compositions for identification of prostate cancer markers: In some embodiments, the invention comprises methods and compositions for the assessment of prostate cancer in humans by determining the level of certain markers indicative of prostate cancer in vivo, including but not limited to SEQ ID NO:1 and SEQ ID NO:5, in tissue, blood, urine, or other biological samples.... Agent: Rader, Fishman & Grauer PLLC
20110045481 - Methods and compositions for the assessment of drug response: The present invention provides methods for predicting or determining a subject's response to an antiplatelet agent, and methods for determining a subject's suitability to a treatment regime or intervention for a disease associated with platelet aggregation, using analysis of genetic polymorphisms. The present invention also relates to the use of... Agent: Casimir Jones, S.c.
20110045471 - Methods for assaying mc1r variants and mitochondrial markers in skin samples: The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying,... Agent: Morgan Lewis & Bockius LLP
20110045480 - Methods for predicting the efficacy of treatment: Clinical tests for testing therapeutic sensitivity of cancerous breast tissue and methods and kits for performing the same are described herein. Embodiments of the present invention are directed to methods for predicting the efficacy of treatment of breast cancer. In addition, certain embodiments are directed to a kit for testing... Agent: Pepper Hamilton LLP
20110045487 - Methods of diagnosing myelodysplastic syndrome (mds) or leukemia using nucleic acids or fragments encoding flt3 kinase: To provide a nucleic acid encoding a receptor protein kinase, wherein the nucleic acid has tandem duplication in a nucleotide sequence of a juxtamembrane and is useful for diagnosis of leukemia; a polypeptide encoded by the nucleic acid; an antibody capable of specifically binding to a region encoded by the... Agent: Birch Stewart Kolasch & Birch
20110045488 - Methods of diagnosing myelodysplastic syndrome (mds) or leukemia using nucleic acids or fragments encoding flt3 kinase: To provide a nucleic acid encoding a receptor protein kinase, wherein the nucleic acid has tandem duplication in a nucleotide sequence of a juxtamembrane and is useful for diagnosis of leukemia; a polypeptide encoded by the nucleic acid; an antibody capable of specifically binding to a region encoded by the... Agent: Birch Stewart Kolasch & Birch
20110045460 - Mitochondrial complex i mutations in parkinson's disease & aging: The present invention provides methods for diagnosing and treating Parkinson's disease based on mitochondrial mutations. The present invention also provides methods for diagnosing and treating other diseases and disorders based on mitochondrial mutations.... Agent: Wolf Greenfield & Sacks, P.C.
20110045459 - Molecular determinants of egfr kinase inhibitor response in glioblastoma: The invention disclosed herein provides methods for the examination and/or quantification of biochemical pathways that are disregulated in pathologies such as cancer and to reagents and kits adapted for performing such methods.... Agent: Gates & Cooper LLP Howard Hughes Center
20110045472 - Monitoring enzymatic process: Techniques, apparatus and systems are described for performing label-free monitoring of processes. In one aspect, a label-free monitoring system includes an array of label-free optical sensors to detect an optical signal in response to synthesis of one or more target genetic structures. Each label-free optical sensor is functionalized with a... Agent: Fish & Richardson P.C. (sd)
20110045470 - Pathogen detection in large-volume particulate samples: Methods and filter systems for detecting microorganisms in a sample, such as a food sample, are disclosed. The filter is configured to attract the microorganism, for example by electrostatic charge. The filter containing the microorganism is incubated to grow the microorganism so that it may be detected. The filter may... Agent: Buchanan, Ingersoll & Rooney PC
20110045467 - Peripheral neuropathy diagnosis: Genes whose expression is correlated with the presence of CIDP or vasculitic neuropathy are disclosed. Probes and sets of nucleic acid and proteins specific for these genes are described, as are molecular and immunological methods for aiding in the diagnosis of these disease conditions in a subject.... Agent: Venable LLP
20110045489 - Polymerases for incorporating modified nucleotides: Compositions and methods are provided that relate to a recombinant protein with DNA polymerase activity in which one or more amino acids are mutated compared with the corresponding wild type protein. The recombinant protein is capable of incorporating one or more modified nucleotides into a nucleic acid substrate with a... Agent: Harriet M. Strimpel, D. Phil.
20110045468 - Polynucleotides for the identification and quantification of group a streptococcus nucleic acids: The present invention provides polynucleotides that can specifically hybridize to Group A Streptococcus (GAS) nucleic acids from all genotypes. These polynucleotides can be used in genotype-independent detection and quantitation of GAS nucleic acids. For example, the polynucleotides can be used as primers and/or probes in amplification-based assays for either end-point... Agent: Jacob C. Ong
20110045482 - Screening methods for identifying target antifungal genes and compounds by detecting cell surface glycoproteins: The present invention relates to an assay method that can be used for high-throughput detection of cell surface glycoproteins. Specifically, the secretion of a chimeric glycoprotein reporter signals disruption of GPI anchor-mediated attachment of the glycoprotein to the cell surface. This method provides a high signal-to-noise ratio and is particularly... Agent: Scully Scott Murphy & Presser, PC
20110045469 - Snps associated with fatty acid composition of bovine meat and milk: The present invention provides compositions and methods for genotyping bovines including dairy cows and beef cattle More particularly, the invention is directed to single nucleotide polymorphisms in Stearoyl-CoA-Desaturase 5 (SCD5) Sterol regulatory element-binding protein-1 (SREBP1). SREBP cleavage-activating protein (SCAP), Insulin induced protein 1 (INS1G1). Insulin induced protein 2 (INS1G2) and... Agent: Weaver Austin Villeneuve & Sampson LLP
20110045486 - Susceptibility gene for alzheimer's disease: The invention relates to genetic screens for susceptibility to Alzheimer's disease. In particular, the invention provides genetic screens based on genotyping of the p21E2c31 A/T polymorphism and/or the p21E3+20 C/T polymorphism in the p21cip 1 gene.... Agent: Edell, Shapiro & Finnan, LLC
20110045475 - Upregulation of rack-1 in melanoma and its use as a marker: The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocytic cell of said mammal, and the deduction of the presence of a melanoma from the overexpression of RACK-1 protein. The invention is also directed to... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110045461 - Use of anti-microbial peptides as bacterial infection resistance markers in penaeoid shrimp: The present invention relates to the use of transcripts of genes encoding antimicrobial peptides, for evaluating the resistance of penaeid shrimp, in particular of the species Litopenaeus stylirostris, to bacterial infections, in particular to vibriosis.... Agent: Morgan Lewis & Bockius LLP
20110045490 - Biomarker for the prediction of responsiveness to an anti-tumour necrosis factor alpha (tnf) treatment: The invention refers to a method for diagnosing an individual who is to be subjected to or is being subjected to an anti-tumour necrosis factor alpha (TNFα or TNF) treatment to assess the responsiveness to an anti-TNF treatment which comprises the detection of immunoglobulin(s) against one or more biomarker proteins... Agent: Fanelli Strain & Haag PLLC
20110045491 - Cyclic nucleotide-specific phosphodiesterases from leishmania and uses thereof: The present invention, relates to novel amino acid and nucleic acid sequences of cyclic nucleotide-specific phosphodiesterases from the parasite Leishmania major. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the amino acid and... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20110045493 - Hydrophilic, high protein binding, low fluorescence, western blotting membrane: Hydrophilic membrane particularly suited for blotting applications, preferably Western blotting. A pre-wet hydrophobic membrane substrate, preferably made of PVDF, is contacted with a monomer solution and subjected to a UV-initiated free radical polymerization step to render the substrate permanently hydrophilic. The resulting membrane exhibits low background fluorescence, high protein binding,... Agent: Nields, Lemack & Frame, LLC
20110045492 - Microfluidic system and a method of performing a test: d
20110045500 - Cell culture method and screening method: Provided is a cell culture method whereby an in vivo function can be sustained over a long period of time and culture can be conducted using the minimum number of cells required. The cell culture method includes culturing undifferentiated cells in a layered state in a partitioned micro-space and obtains... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110045496 - Gal alpha 1-3gal-containing n-glycans in glycoprotein products derived from cho cells: The present invention provides methods of evaluating CHO cells.... Agent: Choate, Hall & Stewart LLP
20110045497 - Novel acidic glycan markers of human cells: The invention is directed to the analysis of novel acidic glycan markers of several types of human cells. The analysis is performed by mass spectrometry or specific binder molecules.... Agent: Birch Stewart Kolasch & Birch
20110045498 - On-site liquid production: A biological sample processing system for on-site liquid production comprises a processing apparatus for processing of biological samples arranged on microscope slides, and a production unit connected to the apparatus. The production unit comprises a first ingredient source, a second ingredient source, and a mixer station. The mixer station is... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20110045499 - Screening systems utilizing rtp801: b
20110045502 - Monoclonal antibodies and uses thereof: The technology relates to monoclonal antibodies useful in the identification of cancer cells. In one embodiment, mAbs with specificity for tumor antigens are provided. In one embodiment, methods for treating cancer using mAbs are provided. In another embodiment, methods for detecting cancerous cells are provided. In another embodiment, kits for... Agent: Patrick J. Halloran, Ph.d., J.d
20110045501 - St2-based dengue fever diagnostic: A cytokine receptor family member (ST2), which has membrane bound as well as soluble bound forms, is elevated in patients during acute phase of dengue fever. Moreover, secondary cases of dengue fever had even more pronounced elevation of ST2 in serum in comparison to primary cases. One possible role of... Agent: Medlen & Carroll, LLP
20110045503 - The use of novel coumarins as glutathione and thiol labels: Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells.... Agent: Life Technologies Corporation C/o Intellevate
20110045494 - Cancer detection methods and techniques: A method is provided for detecting and/or measuring the occurrence of an enzyme in the form of CYP1B1 in a patient for the detection of cancer in said patient. The method includes the steps of administering a reporter substrate to a patient; taking a bodily fluid and/or tissue sample from... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP
20110045495 - Composition and method for diagnosis or detection of renal cancer: The present invention relates to a method for detection of a renal cancer, comprising measuring any one of or a plurality of polypeptides shown in SEQ ID NOS: 1-7, mutants thereof, or fragments thereof in a biological sample from a subject, and to a composition for diagnosis or detection of... Agent: Birch Stewart Kolasch & Birch
20110045506 - Chemiluminescent enzyme assay method and apparatus: A chemiluminescent enzyme immunoassay method for quantifying antigen or antibody using 1,1′-oxalyldiimidazole (ODI) derivative or 1,1′-oxalyldisodium benzoate (ODB) derivative chemiluminescence (CL) detection was developed. Also, various enzymes were quantified using ODI derivative or DOB derivative CL detection. Fluorescent compound formed from a substrate (non-fluorescent compound) through the enzyme assay methods... Agent: Steptoe & Johnson PLLC
20110045507 - Fstl-1 as a biomaker of inflammation: The invention provides methods and kits for diagnosing severity of particular types of inflammatory diseases, such as rheumatic diseases, by assessing protein levels of follistatin-like protein 1 (FSTL-1). The level of FSTL-1 protein present in the serum or synovial fluid of individuals suspected of having certain inflammatory disease (e.g, rheumatoid... Agent: Baker Botts L.L.P.
20110045505 - Integrated separation and detection cartridge with means and method for increasing signal to noise ratio: The present invention relates to a device and a method for quantitative detecting of the presence or absence of a target analyte in a liquid sample having a volume of less than 200 μl, the device comprising a reaction chamber in the form of a capillary channel, a first part... Agent: The Nath Law Group
20110045509 - Method for determining the type of an inflammatory-rheumatic disease in synovial fluid: Disclosed is an in vitro method for determining the type of an inflammatory-rheumatic disease, wherein the presence or absence of the protein Hdj2 in synovial fluid is determined at an early stage of the disease.... Agent: Curatolo Sidoti Co., Lpa
20110045511 - Methods of monitoring the modulation of the kinase activity of fibroblast growth factor receptor and uses of said method: The present invention relates generally to methods of in vitro diagnostics, in particular the use of a compound selected from the group consisting of fibroblast growth factor 23 (FGF23), inorganic phosphorus (P), the product of inorganic phosphorus and total calcium (P×tCa), osteopontin (OPN) and parathyroid hormone (PTH) as biomarker. Said... Agent: Novartis Corporate Intellectual Property
20110045510 - Pegylated insulin-like-growth-factor assay: The current invention reports an immunoassay for the determination of PEGylated insulin-like-growth-factor employing an anti-(polyethylene glycol) antibody and an anti-digoxygenin antibody for the detection of an insulin-like-growth-factor/insulin-like-growth-factor-binding-protein-complex.... Agent: Hoffmann-la Roche Inc. Patent Law Department
20110045504 - Prognostic prediction method for acute coronary syndrome: Problem is to provide a diagnostic marker for prognostic prediction of acute coronary syndrome. Means to solve the Problem is to make it possible to predict the risk of recurrence of acute coronary syndrome by measuring the concentration of soluble LOX-1 in the blood.... Agent: Wenderoth, Lind & Ponack, L.L.P.
20110045508 - Urinary ca125 peptides as biomarkers of ovarian cancer: The present invention is directed to diagnostic methods based upon the detection of peptides derived from the degradation of CA125. In particular, it is concerned with assays of urine samples collected from women for the purpose of determining whether they are at increased risk for having ovarian cancer, have decreased... Agent: Law Office Of Michael A. Sanzo, LLC
20110045512 - Time-course measurement of enzymatic activity corrected for impacts of disturbances relating to the reaction of the enzyme with a substrate: A method of determining the course of enzyme activity that is variable in time, wherein the activity is probed by conversion of a substrate of the enzyme, includes, in a selected test set up and for a determined substrate of the enzyme, determining the velocity of signal production (dFdiag/dt) resulting... Agent: Young & Thompson
20110045513 - Protein electron mediator: The present invention relates to an electron mediator for glucose oxidoreductase comprising extracellular secretion type cytochrome, a fusion body in which the electron mediator is fused with glucose oxidoreductase, a composition for glucose measurement including the electron mediator or fusion body, a gene encoding a new extracellular secretion type cytochrome,... Agent: Wenderoth, Lind & Ponack, L.L.P.
20110045515 - Method to detect hemolytic streptococcus and optoelectrically determine results: A reagent is provided for the detection of an exotoxin protein produced by a betahemolytic streptococcus bacteria suspected of being present in a host biological fluid collected from a subject. A kit is provided that is readily usable by an unskilled user and merely requires that an element of the... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c
20110045514 - Methods for detecting major adverse cardiovascular and cerebrovascular events: The present teachings relate to a method of assessing the probability of a major adverse cardiovascular or cerebrovascular event in a human. The method can include measuring a concentration, in a blood-based sample of a human, of a set of analytes, for example, alpha-fetoprotein, cancer antigen 125, glutathione S-transferase, and... Agent: K&l Gates LLP
20110045516 - Kits pertaining to analyte determination: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.... Agent: Life Technologies Corporation C/o Intellevate
20110045517 - Toxic material detection apparatus and method: A toxic material detection apparatus includes a sample collection portion including a sample inlet and a sample concentrator adapted to concentrate an environmental sample on a substrate. A sample distributing system transfers portions of the substrate to a color sensor and an ion mobility spectrometer for simultaneously analysis and toxin... Agent: Diederiks & Whitelaw, PLC
20110045518 - Ykl-40 as a general marker for non-specific disease: The present invention relates to methods of diagnosing the presence of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above a reference level indicates the presence of a non-specific disease or disorder. The subject may suffer from a variety of diseases or disorders. The... Agent: Clark & Elbing LLP
20110045519 - Differentiated immortalised cell lines capable of producing albumin and blood coagulation factors, methods of preparing thereof from a leukaemia cell line and uses thereof: The invention relates to cell lines from differentiated cells with hepatocytic phenotypes capable of producing albumin and blood coagulation factors, said cells being derived from a human leukaemia cell line, preferably the human THP1 cell line, and preserving the characteristics of immortality. Among the cell lines of the invention, the... Agent: Steinfl & Bruno
20110045520 - Fatty acid markers for the diagnosis, prognosis and management of cardiovascular disease: Methods of detecting myocardial infarction are disclosed based on elevated levels of one or more free fatty acids. The methods may comprise detection of elevated levels of total free fatty acids in a sample relative to average total free fatty acid levels in a control subject without myocardial infarction. Also... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20110045522 - Methods for diagnosing diabetes and determining effectiveness of treatments: The invention generally relates to novel methods of measuring the effectiveness of a drug for the treatment of diabetes and methods of diagnosing diabetes. In some embodiments of the invention, IL-1Ra is used as a biomarker to measure the effectiveness of a drug for the treatment of diabetes.... Agent: Wood, Phillips, Katz, Clark & Mortimer
20110045523 - Optical nanosensors comprising photoluminescent nanostructures: Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described. Generally, the nanosensors comprise a photoluminescent nanostructure and a polymer that interacts with the photoluminescent nanostructure. In some cases, the interaction between the polymer and the nanostructure can be non-covalent (e.g., via van der Waals interactions). The... Agent: Steptoe & Johnson LLP
20110045521 - Sample processing apparatus and sample processing method: According to an embodiment, a sample processing apparatus includes, a processing unit configured to subject a sample container or a sample contained in the sample container to processing, and a label removal unit configured to remove at least part of a label affixed to a side part of the sample... Agent: Nixon & Vanderhye, PC
20110045524 - Transfection ready eukaryotic cells: Described herein are frozen populations of transfection ready competent eukaryotic cells, transfection kits comprising the frozen populations of transfection ready competent cells, and methods of using the same.... Agent: Knobbe Martens Olson & Bear LLP
20110045525 - Method for flagging a sample: A hematology analyzer is provided. In certain embodiments, the hematology analyzer comprises: a) a flow cell; b) a light source for directing light to the flow cell; c) a plurality of detectors for detecting a plurality of optical characteristics of a blood cell passing through the flow cell; and d)... Agent: Paul D. Yasger Abbott Laboratories
20110045526 - Selection of useful fungal strains: The present invention provides methods for screening for a desired filamentous fungus that produces cellulase more efficiently and/or with increased specific activity. It also provides filamentous fungi that produce cellulase more efficiently.... Agent: Danisco US Inc. Attention: Legal Department
20110045527 - Measurement of protein using inclusion body dry weight: The present invention is directed to improved methods for efficiently producing recombinant proteins. More specifically, the invention relates to a process for calculating the protein in inclusion bodies before the refolding step in large scale recombinant protein production, thereby improving the efficiency of the refolding step and overall yield and... Agent: Marshall, Gerstein & Borun LLP
20110045528 - Apparatus and method for enhanced disruption and extraction of intracellular materials from microbial cells: Provided are surprisingly beneficial osmotic stress shock methods for facilitating disruption and/or extraction of microorganisms, comprising a synergistic combination of at least one hypotonic shock and at least two hypertonic shocks, wherein the last shock is a hypertonic shock. Preferred aspects of the invention relate to facilitating disruption of a... Agent: Davis Wright Tremaine, LLP/seattle
20110045529 - Method and gene for providing or enhancing nonspecific adhesive property and/or autoagglutinating property for microorganisms: A method for providing or enhancing a nonspecific adhesive property, an autoagglutinating property, or both properties in a microorganism is provided. The method comprises introducing a nucleic acid encoding autotransporter adhesin from a microorganism having a nonspecific adhesion property into a target microorganism.... Agent: Mccarter & English, LLP Wilmington Basil S. Krikelis
20110045530 - Enzymatic conjugation of bioactive moieties: The present invention relates to a method for selective conjugation of bioactive moieties to a polymer or polymerisable compound. The method is more specifically related to the selective conjugation of bioactive moieties to a pendant carboxylic acid, ester or thioester group in which the pendant group is part of a... Agent: Nixon & Vanderhye, PC
20110045531 - Method for producing a recombinant protein on a manufacturing scale: A method for producing a protein of interest on a manufacturing scale is based on integration, by homologous recombination, of the DNA encoding the protein of interest into a bacterial cell genome at a pre-selected site. The manufacturing scale production of recombinant proteins is in the fed-batch mode, semi-continuous or... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation
20110045533 - Production of glycosylated polypeptides in micro algae: Transformed microalgae capable of expressing glycosylated polypeptides and methods for producing said transformed microalgae and producing glycosylated polypeptides.... Agent: Young & Thompson
20110045532 - Protein production method: This invention relates to a method for producing a protein of interest, comprising introducing a protein expression vector which comprises a gene fragment a gene fragment comprising a DNA encoding a protein of interest and a selectable marker gene and transposon sequences at both terminals of the gene fragment, into... Agent: Sughrue-265550
20110045535 - Activator for blood coagulation factor vii promoter and utilization of the same: It is intended to provide an activator for blood coagulation factor VII. Ribavirin or its derivative is used as an activator for blood coagulation factor VII promoter.... Agent: Oliff & Berridge, PLC
20110045537 - Human anti-ifn-gamma neutralizing antibodies as selective ifn-gamma pathway inhibitors: This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-γ. Methods of detecting the amount of IFN-γ in a sample using antibodies to IFN-γ are also provided.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20110045536 - Mammalian expression vector: The invention provides vector nucleic acid for expressing at least one polypeptide of interest in a mammalian cell, comprising (a) at least one expression cassette (POI) for expressing a polypeptide of interest; (b) an expression cassette (MSM) comprising a mammalian selectable marker gene; (c) an expression cassette (MASM) comprising a... Agent: Hamilton Desanctis & Cha, LLP
20110045534 - Nucleic acid cassette for producing recombinant antibodies: The invention provides a nucleic acid cassette comprising components in the following structure: A-B-C, wherein “A” is a nucleic acid sequence encoding a light chain of a first antibody (or antigen binding domain thereof), “B” is a nucleic acid sequence encoding a 2A peptide, “C” is a nucleic acid sequence... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel
20110045538 - Peptide, use of the peptide, method for the production of the peptide, solid support having the peptide immobilized thereon, and method for production of the solid support: The peptide contains a variable region to which an antigen-binding site is to be formed and has an amino acid sequence expressing a specific adsorption function to a solid phase at a site closer to the C-terminal than a heavy-chain variable region or at a site closer to the C-terminal... Agent: Edell, Shapiro & Finnan, LLC
20110045539 - Methods and materials for the production of shikimic acid: Novel enzymes and novel enzymatic pathways for the pyruvate-based synthesis of shikimate or at least one intermediate thereto or derivative thereof, nucleic acids encoding the enzymes, cells transformed therewith, and kits containing said enzymes, cells, or nucleic acid. A KDPGal aldolase is used to perform condensation of pyruvate with D-erythrose... Agent: Greenberg Traurig, LLP
20110045540 - Baculovirus expression vector and method therewith for generating immunogenicity in a host: A baculovirus expression vector achieves dual functions of (1) subunit vaccine by displaying the influenza surface protein for humoral immune responses; and (2) DNA vaccine by expressing influenza surface protein for long-acting cellular immune response. A method for inducing immunogenicity in a host is also disclosed.... Agent: Muncy, Geissler, Olds & Lowe, PLLC
20110045541 - Method of nucleic acid amplification: A nucleic acid molecule can be annealed to an appropriate immobilised primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer can then be annealed to another immobilised primer and the other primer can be extended. Both extended... Agent: Illumina, Inc. Legal Department
20110045542 - Amplification of bisulfite-reacted nucleic acids: The present invention relates to a reaction mixture for the amplification of nucleic acids, the non-methylated cytosine bases of which have been converted to uracil bases by means of a bisulfition reaction. The invention also discloses methods for amplifying bisulfited nucleic acid and for determining the nucleic acid methylation state,... Agent: Ballard Spahr LLP
20110045543 - Process for production of 5'-guanylic acid: By reacting inosinic acid (IMP) with a bacterium which has been modified so that IMP dehydrogenase activity and 5′-guanylic acid (GMP) synthetase activity are enhanced, GMP is produced.... Agent: Cermak Nakajima LLP Acs LLC
20110045544 - Treatment of cellulosic material and enzymes useful therein: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme... Agent: Banner & Witcoff, Ltd.
20110045545 - Method and preparing glucan and mannan, glucan preparation and mannan preparation produced thereby and use thereof: The present invention provides a method for extracting glucan and mannan from the cell wall of a microorganism. Specifically, the method of the present invention in one embodiment comprises the steps of: a) treating the cells of the microorganism with an alkaline protease and an mannanase; b) separating the mixture... Agent: Townsend And Townsend And Crew, LLP
20110045546 - Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose: This invention provides novel enzyme compositions using newly identified and isolated C. lucknowense enzymes, including CBH Ib CBH IIb, EG II, EG VI, β-glucosidase, and xylanase II in conjunction with previously identified enzymes CBH Ia, CBH IIa (previously described as Endo 43), and EG V. These enzyme compositions demonstrate an... Agent: Mcdermott Will & Emery LLP
20110045547 - Isomerases and epimerases and methods of using: The invention provides for isomerase (e.g., racemase) and epimerase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such isomerase (e.g., racemase) and epimerase nucleic acids and polypeptides.... Agent: Cargill, Incorporated
20110045549 - Polynucleotides encoding a feedback resistant aspartokinase from corynebacterium: The invention provides methods to increase the production of an amino acid from Corynebacterium species by way of the amplification of amino acid biosynthetic pathway genes in a host cell chromosome. The invention also provides novel processes for the production of an amino acid by way of the amplification of... Agent: Buchanan Ingersoll & Rooney PC (archer Daniels Midland Company)
20110045550 - Fission yeast expressing cytochrome p450 reductase: The present invention refers to a recombinant fission yeast strain useful for the improved production of human cytochrome P450s. The improvement in the cytochrome P450 rate is achieved by a coexpression of a functional human electron transfer chain e.g. CPR (cytochrome P450 reductase). The invention further relates to uses of... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20110045551 - Method for producing an optically active compound: A method for producing an optically active compound includes reacting a nucleophile with a mixture of R- and S-stereoisomers of an azolide substrate by enzyme-catalyzed kinetic resolution so as to produce the optically active compound, wherein the azolide substrate contains an azole group used as a leaving group and an... Agent: Occhiuti Rohlicek & Tsao, LLP
20110045552 - Novel gene sms 43: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C) and/or 2-keto-L-gulonic acid (hereinafter also referred to as 2-KGA). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes... Agent: Nixon & Vanderhye, PC
20110045553 - Process for converting tryptophan into kynurenine: A process for converting tryptophan into kynurenine. The conversion of tryptophan into kynurenine is carried out by irradiating a substance comprising tryptophan with electromagnetic radiation comprising waves with wavelength in the range of 10 nanometer to 750 nanometer.... Agent: Huntsman International LLC
20110045556 - Algal lipid harvest using mollusks for biofuels production: Embodiments of the present disclosure provide for novel strategies to harvest algal lipids using mollusks which after feeding algae from the growth medium can convert algal lipids into their biomass or excrete lipids in their pseudofeces which makes algae harvesting energy efficient and cost effective. The bioconverter, filter-feeding mollusks and... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP
20110045555 - Enzymatic modification of oil: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.... Agent: Mckeon Meunier Carlin & Curfman LLC
20110045554 - Heterologous expression of extremophile heat shock proteins and chaperones in microorganisms to increase tolerance to toxic compounds: The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating microorganisms. The methods comprise engineering a microorganism of interest to express a heterologous heat-shock protein/chaperone, e.g., Group II chaperonin or a prefoldin such as γ-prefoldin,... Agent: Townsend And Townsend And Crew, LLP
20110045557 - Novel fusion carbonic anhydrase/cellulose binding polypeptide encoded by a novel hybrid gene, and method of creating and using the same: The invention relates a novel hybrid carbonic anhydrase catalyst with the potential to contribute significantly to meeting targeted reductions in greenhouse gas emissions. In a preferred embodiment of the present invention at least a portion of a cellulose binding domain (CBD) of a protein is fused to another protein, carbonic... Agent: United States Department Of Energy
20110045558 - Process for the preparation of citric acid employing filamentous fungi in a culture medium comprising glycerol: The present invention relates to a method for producing citric acid from glycerol with a yield of more than 70%. The method comprises fermenting a filamentous fungus on a substrate which comprises glycerol. The advantage of the method according to the invention is that a widely available substrate, i.e. glycerol,... Agent: Nixon & Vanderhye, PC
20110045559 - Malic acid production in recombinant yeast: The present disclosure relates to modified yeast, wherein the yeast has reduced pyruvate decarboxylase polypeptide (PDC) activity and methods of using such yeast to produce malic and/or succinic acid.... Agent: Fish & Richardson P.C. (bo)
20110045560 - Method for producing optically active 2-methyl-alkanols: e
20110045562 - Development of strains of the thermotolerant yeast hansenula polymorpha capable of alcoholic fermentation of starch and xylan by expression of starch and xylan degrading enzymes: Genes SWA2 and GAMl from the yeast, Schwanniomyces occidentalis, encoding α-amylase and glucoamylase, respectively, were cloned and expressed in H. polymorpha. The expression was achieved by integration of the SWA2 and GAM1 genes into the chromosome of H. polymorpha under operably linked to a strong constitutive promoter of the H.... Agent: Archer Daniels Midland Company
20110045561 - Method of stimulating ethanol production and growth of aquatic plants: A method of stimulating ethanol production and growth of aquatic plants includes the steps of placing aquatic plants in a cell containing water and creating an oxygenated condition within the cell to initiate an aerobic process. The aquatic plants create and store carbohydrates during the aerobic process. The cell is... Agent: Sean Kaufhold
20110045563 - Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi: The present invention provides methods and compositions for producing isoprene hydrocarbons from Ascomycota such as yeast and filamentous fungi.... Agent: Townsend And Townsend And Crew, LLP
20110045564 - Method of enhanced sustainable production of algal bio-products, comprising use of symbiotic diazotroph-attenuated stress co-cultivation: Provided are compositions and methods for sustainable cultivation of algae for biomass, biofuel and bioproduct production, preferably with minimal addition of exogenous nutrients, comprising co-cultivating at least one algal species with at least one aerobic bacterial species and at least one diazotroph (or, in certain embodiments, cultivation of at least... Agent: Davis Wright Tremaine, LLP/seattle
20110045566 - method for preparing the decellularized matrix: A method for preparing the decellularized matrix using the phospholipase includes the following steps: pretreating the standby tissue and organ; putting the standby tissue and organ into the solution containing the phospholipase; preparing the decellularized matrix in the control condition; washing the prepared decellularized matrix.... Agent: Seyfarth Shaw LLP
20110045565 - Apparatus and method for accelerated tissue infiltration by means of microwave excitation: A tissue infiltration apparatus, system and method are described, allowing accelerating infiltration of the tissue sample with a variety of reagents fluids. The apparatus comprises a reaction chamber adapted to receive a tissue sample and a dielectric fluid to be infiltrated into a tissue sample. The reaction chamber comprises a... Agent: Alexander R Schlee SchleeIPInternational P.C.
20110045567 - Method for producing entrapping immobilization pellets, apparatus for producing the same, and entrapping immobilization pellets: It is possible to eliminate fluctuation in the pellet strength of the entrapping immobilization pellets according to production lots, and constantly and stably produce the entrapping immobilization pellets having high pellet strength regardless of the production lots. An apparatus for producing entrapping immobilization pellets by polymerizing an immobilizing material into... Agent: Antonelli, Terry, Stout & Kraus, LLP
20110045568 - Method for restoring bmp-receptor signaling in a cell: The invention relates to a method for restoring BMP-receptor signaling in a cell. According to the invention, the activity of the protein cGKI is increased in a cell. Furthermore, the invention relates to the use of cGKI for the treatment of a disease selected from the group consisting of pulmonary... Agent: Lowe Hauptman Ham & Berner, LLP
20110045569 - Enzymatic conversion of blood group a, b, and ab red blood cells using alpha-n- acetylgalactosaminidases and alpha-galactosidases with unique substrate specificities and kinetic properties: This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique α-N-acetylgalactosaminidases and α-galactosidases with superior kinetic properties for removing... Agent: Foley & Lardner LLP
20110045570 - Novel high alkaline protease and use thereof: i
20110045571 - Proteases with modified pro regions: The present invention provides methods and compositions for the production of mature proteases in bacterial host cells. The compositions include modified polynucleotides that encode modified proteases, which have at least one mutation in the pro region; the modified serine proteases encoded by the modified polynucleotides; expression cassettes, DNA constructs, and... Agent: Danisco US Inc. Attention: Legal Department
20110045572 - Protein variants having modified immunogenicity: The present invention relates to a method of selecting a protein variant having modified immunogenicity as compared to the parent protein comprising the steps obtaining antibody binding peptide sequences, using the sequences to localise epitope sequences on the 3-dimensional structure of parent protein, defining an epitope area including amino acids... Agent: Novozymes North America, Inc.
20110045573 - Alanine 2, 3-aminomutase: Alanine 2,3-aminomutase sequences are disclosed, as are cells having alanine 2,3-aminomutase activity and methods of selecting for such cells. Methods for producing beta-alanine, pantothenate, 3-hydroxypropionic acid, as well as other organic compounds, are disclosed.... Agent: Klarquist Sparkman, LLP
20110045574 - Chromatography medium: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates... Agent: Ge Healthcare Bio-sciences Corp. Patent Department
20110045575 - Microorganisms for the production of 1,4-butanediol and related methods: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to... Agent: Mcdermott Will & Emery LLP
20110045576 - Carbonic anhydrase system and process for co2 containing gas effluent treatment: A triphasic bioreactor for physico-chemically treating a gas is disclosed. The triphasic bioreactor comprises a reaction chamber with a liquid and biocatalysts in suspension in the liquid, for catalyzing a reaction between the gas and the liquid to obtain a treated gas and a solution containing a reaction product. A... Agent: Ware Fressola Van Der Sluys & Adolphson, LLP
20110045577 - Fabrication of conductive pathways, microcircuits and microstructures in microfluidic networks: Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter... Agent: Harvard University & Medical School C/o Wolf, Greenfield & Sacks, P.C.
20110045578 - Method of manufacturing biosensor and biosensor produced thereby: Provided are a biosensor and a method of manufacturing the same which can reduce an amount of liquid specimen required for measurement (a required amount of the liquid specimen), and conduct measurement with higher accuracy. In the biosensor, the liquid specimen is developed on a development layer by using chromatography... Agent: Hamre, Schumann, Mueller & Larson P.C.
20110045579 - Biosensor: Provided is a biosensor with precision, high accuracy, and high sensitivity capable of increasing measurement accuracy while allowing measurements to be performed anywhere at any time by anyone, and allowing measurement with a small amount of specimen. In a biosensor including a specimen application portion (12) and a development flow... Agent: Hamre, Schumann, Mueller & Larson P.C.
20110045580 - In-situ reclaimable anaerobic composter: An in-situ dry anaerobic composter containing 40% to 75% by weight solids and located in a section of ground including a pit having side walls and a bottom, an essentially impervious liner located in the pit such that the liner abuts the pit side walls and bottom to form a... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20110045581 - Bioreactor for continuous production of bioleaching solutions for inoculation and irrigation of sulfide-ore bioleaching heaps and dumps: The invention discloses an air-lift bioreactor, with internal recirculation, for producing sulfide-ore and minerals bioleaching solutions, with a phase-separating and solids-recirculation system without needing to impel the suspension containing the solids to the bioreactor by means of pumps, using diatomaceous earth and/or ferric precipitates as solid support to immobilize iron... Agent: Merchant & Gould PC
20110045582 - Methods and apparatus for integrated cell handling and measurements: Method and systems that provide improved cell handling and assays in microfluidic systems and devices particularly using lateral cell trapping and methods of fabrication of the same.... Agent: Quine Intellectual Property Law Group, P.C.
20110045584 - Expression vector suitable for expression of a coding sequence for gene therapy: Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used... Agent: Sughrue Mion, PLLC
20110045583 - Infectivity-enhanced conditionally-replicative adenovirus and uses thereof: A modified adenovirus capable of overcoming the problem of low level of coxsackie-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber protein of the adenovirus is modified by insertion or replacement so as to target the adenovirus to tumor cells, and the... Agent: Fulbright & Jaworski L.L.P.
20110045585 - Kit for fluorometric analysis: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.... Agent: Mckinney Law Group, Apc
20110045586 - Methods and compositions for expressing negative-sense viral rna in canine cells: The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make... Agent: Grant Anderson LLP
20110045587 - Toxin peptide therapeutic agents: and multimers thereof, in which F1 and F2 are half-life extending moieties, and d and e are each independently 0 or 1, provided that at least one of d and e is 1; X1, X2, and X3 are each independently -(L)f-P-(L)g-, and f and g are each independently 0 or... Agent: Amgen Inc.
20110045588 - Method for culturing human periosteum: The present invention provides a method for forcingly culturing a piece of human periosteum tissue in a shorter culture period, the method including the steps of: (1) placing a periosteum piece dissected from a patient on a culture dish containing no culture solution; (2) dropping platelet-rich plasma collected from the... Agent: Mcdermott Will & Emery LLP
20110045589 - Methods of controlling proliferation and differentiation of stem and progenitor cells: A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20110045590 - Calcium-influx inhibitory factor and method of isolation thereof: A purified factor isolated from human milk is provided. The factor is capable of inhibiting calcium-influx activity in polymorphonuclear leukocytes. A method for purification of the factor is also provided.... Agent: Wilmerhale/dc
20110045591 - Controlled activation of non-ltr retrotransposons in mammals: The invention relates to nucleic acids, vector constructs which allow the controlled activation and inhibition of retrotransposition of non-LTR retrotransposons. The methods of this invention are useful for preparing said nucleic acids and vector constructs and introducing them into cells.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20110045592 - Methods of genome installation in a recipient host cell: The presently disclosed invention relates to methods of installing a genome isolated from one species (the donor) into suitably prepared cells of a second species (the recipient). Introduction of the donor genetic material into the recipient host cell effectively converts the recipient host cell into a new cell that, as... Agent: Synthetic Genomics C/o Morrison & Foerster LLP
20110045593 - Transgenically mitigating the establishment and spread of transgenic algae in natural ecosystems by suppressing the activity of carbonic anhydrase: Genetic mechanisms for mitigating the effects of introgression of a genetically engineered genetic trait of cultivated algae or cyanobacteria to its wild type or to an undesirable, interbreeding related species, as well as preventing the establishment of the transgenic algae or cyanobacteria in natural ecosystems by suppressing the activity of... Agent: Dodds & Associates
20110045594 - Genetic remodeling in bifidobacterium: A Bifidobacterium comprising a genome that is customized so as to lack an operable functional gene is disclosed. A method of making such cells is also disclosed. The method is used to make Bifidobacterium cells that lack certain functional antibiotic resistance genes, such as tetW, and are sensitive to antibiotics... Agent: K&l Gates LLP02/17/2011 > patent applications in patent subcategories. patent applications/inventions, industry category
20110039253 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Oliff & Berridge, PLC
20110039254 - Chromosomal insertion of gfp into bacteria for quality control: An isolated mutated green fluorescent protein (gfp) gene for chromosomal insertion into a bacterium, wherein the gene is capable of being expressed in bacteria and produce sufficient fluorescence under illumination from a UV lamp in a bacterial colony to be seen by the naked eye. A gene cassette for inserting... Agent: Cooley LLP Attn: Patent Group
20110039256 - Detection method: A method for detecting the presence of a diagnostic moiety indicative of exposure to an infectious organism in a biological sample taken from a human or animal, said method comprising; (a) adding to said sample a first fluorescently labelled reagent which binds said diagnostic moiety, and a second fluorescently labelled... Agent: Polsinelli Shughart PC
20110039255 - Method and system for detection of a selected type of molecules in a sample: The present invention refers to a method for detecting molecules and/or substances within a sample based on the use of a microcantilever system. The method comprises the variation of a certain condition such as humidity so as the mechanical feature analysed varies with a characteristic pattern while the target molecule... Agent: Ostrolenk Faber Gerb & Soffen
20110039275 - method for predicting a clinical response of a patient suffering from or at risk of developing cancer towards a given mode of treatment: The present invention relates to a method for predicting a clinical response of a patient suffering from or at risk of developing cancer, preferably colorectal cancer, towards a given mode of treatment, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the expression... Agent: Siemens Corporation Intellectual Property Department
20110039274 - Analysis of nucleic acid amplification curves using wavelet transformation: A method comprising acquiring amplification data proportional to an amount of nucleic acid present for each of a plurality of PCR cycles includes applying wavelet transformation to the amplification data to determine a PCR cycle corresponding to a point within a growth period of the amplification data, and updating a... Agent: 3m Innovative Properties Company
20110039268 - Cytokine protein family: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral... Agent: Zymogenetics, Inc. Intellectual Property Department
20110039259 - Dna sequence with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators: This invention provides a process for sequencing nucleic acids using 3′ modified deoxynucleotide analogues or 3′ modified deoxyinosine triphosphate analogues, and 3′ modified dideoxynucleotide analogues having a detectable marker attached to a base thereof.... Agent: Cooper & Dunham, LLP
20110039266 - Flowcell systems for single molecule detection: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection... Agent: Townsend And Townsend And Crew, LLP
20110039264 - Format of probes to detect nucleic acid differences: The invention provides, inter alia, novel probes, methods, reaction mixtures, and kits for detecting the presence or absence of a target nucleic acid sequence.... Agent: Roche Molecular Systems, Inc.
20110039269 - Gene expression markers for colorectal cancer prognosis: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.... Agent: Genomic Health, Inc. (bozicevic, Field & Francis) C/o Kathleen Determann
20110039270 - Gene expression markers for colorectal cancer prognosis: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.... Agent: Genomic Health, Inc. (bozicevic, Field & Francis) C/o Kathleen Determann
20110039271 - Gene expression markers for colorectal cancer prognosis: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.... Agent: Genomic Health, Inc. (bozicevic, Field & Francis) C/o Kathleen Determann
20110039272 - Gene expression markers for colorectal cancer prognosis: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.... Agent: Genomic Health, Inc. (bozicevic, Field & Francis) C/o Kathleen Determann
20110039273 - Method for measuring dna methylation: The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on.... Agent: Panitch Schwarze Belisario & Nadel LLP
20110039265 - Method of detecting tumor-associated dna in plasma or serum: This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20110039260 - Methods and compositions for amplifying a detectable signal: Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for a nucleic acid, comprising the steps of providing an amplification polymer bound to a nucleic acid analyte, wherein the amplification polymer comprises a plurality of amine groups; binding amine groups on... Agent: Brinks Hofer Gilson & Lione/utah Utah Office
20110039258 - Methods and compositions for differential expansion of fetal cells in maternal blood and their use: Disclosed is a method and compositions for the differential expansion of fetal cells over maternal cells. In the method, cells from a sample of maternal blood containing CD34+ cells of both maternal and fetal origin are incubated in the presence of Stem Cell Factor in serum free media. It has... Agent: Knobbe Martens Olson & Bear LLP
20110039262 - Methods for detecting virulent plasmodium, for evaluating plasmodium virulence, and for screening new drugs employing the 3'utr of plasmodium sub2 and the plasmodium sub2 serine protease: Methods for regulating the serine protease of Plasmodium. Recombinant DNA constructs which express the Plasmodium serine protease, especially those comprising a sub2 3′UTR and coding segment which express a SUB2 a serine protease. Recombinant Plasmodium containing such constructs and exhibiting increased virulence. Methods for detecting virulent Plasmodium strains by detecting... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110039261 - Mobile rapid test system for nucleic acid analysis: A mobile rapid test system for nucleic acid analysis. A method comprising the steps of amplification of the nucleic acids by means of rapid-PCR technology, conversion of a double-stranded amplification product into a single-stranded DNA fragment, hybridization with a labeled probe and detection of the nucleic acids on a lateral-flow... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110039257 - Permuted and nonpermuted luciferase biosensors: A modified luciferase protein which is a sensor for molecules including cAMP, cGMP, calcium, chelators thereof, kinases, or phosphatases is provided. Also provided is a circularly permuted anthozoan luciferase protein and a decapod crustacean luciferase protein, optionally containing one or more heterologous amino acid sequences, at least one of which... Agent: Michael Best & Friedrich LLP
20110039263 - Plants having altered agronomic characteristics under nitrogen limiting conditions and related constructs and methods involving genes encoding lnt2 polypeptides and homologs thereof: Isolated polynucleotides and polypeptides and recombinant DNA constructs particularly useful for altering agronomic characteristics of plants under nitrogen limiting conditions, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110039267 - Sample preparation and detection of analytes using silica beads: This invention provides methods for concentration of analyte from biological sample, or various liquid samples and methods for identification of the analyte. The method includes providing silica beads conjugated with analyte recognition element for concentration of analyte from sample, packaging the beads into a cartridge, and attaching the cartridge to... Agent: Stanislav Torgovitsky Roylance, Abrams, Berdo & Goodman, L.L.P.
20110039276 - Identifying organ damage: The present invention provides methods for identifying whether or not a patient has, or is at risk of developing drug induced organ damage and methods of treating patients having drug induced organ damage. In particular, the invention relates to a method for identifying whether or not a patent has, or... Agent: Schwegman, Lundberg & Woessner, P.A.
20110039277 - Methods of labeling proteins: Methods are provided for labeling specific oxidized proteins. Methods also are provided for determining the oxidation state of a cell. Such methods are useful as diagnostic, therapeutic and screening agents.... Agent: Hirshman Law, LLC
20110039278 - Device and methods for the immunological identification of cerebrospinal fluid: The present disclosure relates to detection of the presence or absence of cerebrospinal fluid (CSF) in a sample by the detection of one or more antigens that are enriched in CSF compared to their levels in other bodily fluids. The devices and methods are suitable for the detection of the... Agent: Cantor Colburn LLP
20110039279 - Methods and compositions for diagnosing breast cancer: Mammastatin has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49... Agent: Casimir Jones, S.c.
20110039280 - Hybrid microfluidic spr and molecular imaging device: A hybrid microfluidic biochip designed to perform multiplexed detection of singled- celled pathogens using a combination of SPR and epi-fluorescence imaging. The device comprises an array of gold spots, each functionalized with a capture biomolecule targeting a specific pathogen. This biosensor array is enclosed by a polydimethylsiloxane (PDMS) microfluidic flow... Agent: Brinks Hofer Gilson & Lione
20110039282 - Method of detecting calcifying nanoparticles and susceptibility to calcifying nanoparticle information: A method of measuring the susceptibility of a subject to calcifying nanoparticle formation is disclosed. The method can include obtaining a cell culture comprising peripheral blood mononuclear cells, immune cells, or both, from a peripheral blood mononuclear fraction of a subject in a complete culture media; extracting a first aliquot... Agent: Gregory A. Nelson Novak Druce & Quigg LLP
20110039281 - Method of immunological analysis for detection of antibodies against human gstt1 (anti-hgstt1): The subject of the present invention is a method of immunological analysis for detection in biological fluids of anti-bodies against human GSTT1 (anti-hGSTT1). The present invention also concerns the use of said immunological analysis method for the diagnosis, prognosis, follow-up and monitoring of pathological conditions associated with the presence of... Agent: Arent Fox LLP
20110039283 - Diagnosis and risk stratification using nt-proet-1: The invention relates to a method for the diagnosis and/or risk stratification of cardiac diseases and diseases of the respiratory tract and lungs. According to said method, the free fragment N-terminal proEndothelin (NT-proET-1; AS 18-52 of the pre-proET according to FIG. 1) or fragments and partial peptides thereof is or... Agent: Connolly Bove Lodge & Hutz, LLP
20110039284 - Methods of prognosis: The invention relates to the field of medical prognostics. In particular, the invention relates to methods for predicting prostate cancer progression and overall survival prognosis in a subject involving the detection of elevated amounts of macrophage inhibitory cytokine-1 (MIC-1) in a test body sample such as serum.... Agent: Nixon & Vanderhye, PC
20110039285 - Microfluidic device and method for fluid clotting time determination: A microfluidic passive device and a method for determining clotting time are described, of a fluid medium such as blood, of low production cost which can therefore be disposable. When optimised to determine blood clotting time, it requires a minimal whole blood sample (<5 μL) and it is particularly suited... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c
20110039286 - Temperature-adjusted analyte determination for biosensor system: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations... Agent: Blanchard & Associates
20110039287 - Method for quantification of peptide and protein: A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or... Agent: Young & Thompson
20110039288 - Reaction medium for methicillin-resistant staphylococcus aureus (mrsa) bacteria: A reaction medium for detecting and/or identifying methicillin-resistant Staphylococcus aureus (MRSA) bacteria includes a chromogenic substrate, a first antibiotic that belongs to the cephalosporin family and a second antibiotic that belongs to the aminoglycoside family.... Agent: Oliff & Berridge, PLC
20110039289 - Fluorogenic peptides and their method of production: A method of making a fluorogenic peptide with an acridone fluorophor is provided, the method comprising the steps of: (a) providing an acridone derivative, said acridone derivative having first and second reactive groups (or precursors thereof), (b) providing a solid phase support provided with reactive species for reacting with the... Agent: Nixon & Vanderhye, PC
20110039290 - Novel dry stick device construction and method for determining an analyte in a sample using said dry stick device: A novel dry stick device construction for the determination of an analyte in a sample is provided. The device comprises: (i) optionally a solid support, (ii) at least one reagent pad comprising a reagent or a combination of reagents capable of reacting with the analyte, a derivative of said analyte... Agent: Foley And Lardner LLP Suite 500
20110039292 - Bioassay for yokukansan: Disclosed is a bioassay system in an in-vitro test that enables higher quality guarantee of yokukansan. A bioassay for yokukansan comprises the steps of culturing cells in a culture medium with serum, adding yokukansan to the cells in a serum-free medium, applying ER stress to the cells to induce cell... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110039291 - Bioremediation of nanomaterials: The present invention provides a method comprising the use of microorganisms for nanotoxicity study and bioremediation. In some embodiment, the microorganisms are bacterial organisms such as Gram negative bacteria, which are used as model organisms to study the nanotoxicity of the fullerene compounds: E. coli W3110, a human related enterobacterium... Agent: United States Department Of Energy
20110039295 - Display with iconic markers for a meter: Meters, methods, and computer-readable media for determining the concentration of an analyte in a fluid sample are presented herein. One concept is directed to a meter for determining the concentration of an analyte in a fluid sample. The meter includes a housing configured to receive a test sensor carrying the... Agent: Nixon Peabody LLP
20110039293 - Effervescent solid pharmaceutical composition comprising dextrose and process for its preparation: The present invention is related to the medicine field. Specifically, the present Invention is related with an effervescent solid pharmaceutical composition of dextrose having as purpose determining the metabolized glucose levels in a patient with diabetes or glucose metabolism related conditions, in a simple and effective manner with respect to... Agent: Holland & Hart, LLP
20110039296 - Method of attaching a cell-of-interest to a microtube: A method of attaching a cell or a membrane-coated particle-of-interest to a microtube is provided. The method comprising: co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20110039294 - System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function: Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the... Agent: Biotech Beach Law Group , PC
20110039297 - Method and device for controlling the fermentation process: A method and device for controlling a fermenting process, wherein the method comprises collecting samples of biological cells from a fermenting tank, obtaining the state information of the current biological cells based on the collected samples, comparing the state information of the current biological cells with preset target status information... Agent: Cohen, Pontani, Lieberman & Pavane LLP
20110039298 - Method of measuring blood sample on blood test instrument using a disposable cartridge: A blood test instrument using a disposable cartridge and a method of measuring a blood sample using the instrument are disclosed. The instrument includes a cell counting station for counting blood cells by electrical resistance measurement, a pressure actuating component adapted to apply a pressure alternately on two flexible receptacles... Agent: Mh2 Technology Law Group, LLP
20110039299 - Production of carotenoids in oleaginous yeast and fungi: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.... Agent: Choate, Hall & Stewart LLP
20110039300 - Antibodies with enhanced adcc functions: The present invention concerns antibodies with enhanced antibody-dependent cell mediated cytotoxicity (ADCC) and method for preparation thereof.... Agent: Arnold & Porter LLP (24126) Attn: Sv Docketing Dept.
20110039301 - Polypeptides having organophosphorous hydrolase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes North America, Inc.
20110039302 - Method of producing factor viii proteins by recombinant methods: Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20110039304 - Methods to generate oligonucleotide pools and enrich target nucleic acid sequences: Methods and compositions for generating oligonucleotide pools are provided. Methods and compositions for enriching target nucleic acid sequences are also provided.... Agent: Banner & Witcoff, Ltd.
20110039303 - Microfluidic and nanofluidic devices, systems, and applications: The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves... Agent: Wilson, Sonsini, Goodrich & Rosati
20110039306 - Reagent containing a thermostable endonuclease: Compositions and methods are provided for preserving the thermostability of an endonuclease in the presence of DNA for uses that include DNA repair. The compositions and methods include the presence of zinc ions.... Agent: Harriet M. Strimpel, D. Phil.
20110039305 - Thermocycler and sample vessel for rapid amplification of dna: A thermocycler apparatus and method for rapidly performing the PCR process employs at least two thermoelectric modules which are in substantial spatial opposition with an interior space present between opposing modules. One or multiple sample vessels are placed in between the modules such that the vessels are subjected to temperature... Agent: Dobrusin & Thennisch PC
20110039307 - Ethanol yields in fermentation from an improved liquefaction process: An improved liquefaction process comprises the use of an increased dose of alpha-amylase coupled with a liquefaction temperature no higher than 99° C., e.g., in the range of about 88-92° C. The improved liquefaction process advantageously omits the conventional high-temperature treatment, e.g., jet-cooking at a temperature of about 95-125° C.,... Agent: Danisco US Inc. Attention: Legal Department
20110039308 - Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them: In one aspect, the invention is directed to polypeptides having an amylase and/or glucoamylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis... Agent: Verenium Corporation Intellectual Property Department
20110039310 - Novel gene sms 37: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, PC
20110039311 - Process for producing fermentation product from lignocellulose-containing material: The invention relates to processes process of producing fermentation products from lignocellulose-containing material comprising: a) pretreating the lignocellulose-containing material; b) preparing a slurry of pretreated lignocellulose-containing material and thermo treated distiller's grain; c) hydrolyzing the slurry with one or more cellulolytic enzymes; d) fermenting with a fermenting organism.... Agent: Novozymes North America, Inc.
20110039309 - Process for treating biomass to derivatize polysaccharides contained therein to increase their accessibility to hydrolysis and subsequent fermentation: A process is described for producing fermentable sugars derivable from biomass that contains polysaccharide, such as cellulose, made increasingly accessible as a substrate for enzymatic degradation or other methods of depolymerization. These fermentable sugars are subsequently able to be fermented to produce various target chemicals, such as alcohols, aldehydes, ketones... Agent: Hercules Incorporated Hercules Plaza
20110039312 - Isolated population of plant single cells and method of preparing same: This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from procambium to promote the stability of the plant-derived biologically active substances production by solving the... Agent: Edwards Angell Palmer & Dodge LLP
20110039313 - Method for the fermentative production of cadaverine: The invention relates to recombinant microorganisms in which polynucleotides which code for lysine decarboxylase are enhanced and, using which, cadaverine (1,5-diaminopentane) is produced fermentatively, with the carbon source used preferably being renewable raw materials such as, for example, glucose, sucrose, molasses and the like.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110039314 - Composition for catalytic amide production and uses thereof: A catalytic composition for the enzymatic conversion of nitriles to amides is disclosed. The composition contains a polymer gel and a nitrile hydratase (NHase). Also disclosed are methods of producing an amide from a nitrile using the catalytic composition.... Agent: Marshall, Gerstein & Borun LLP
20110039315 - Methods and systems for biomass conversion to carboxylic acids and alcohols: The disclosure includes a method, process and apparatus for the conversion of biomass to carboxylic acids and/or primary alcohols. The system may include a pretreatment/fermentation subsystem operable to produce a fermentation broth containing carboxylic acid salts from biomass, such as lignocellulosic biomass. The system may also include a dewatering subsystem... Agent: Conley Rose, P.C. David A. Rose
20110039316 - Yeast mutant and substance production method using the same: e
20110039317 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent: Xyleco, Inc. Celia Leber
20110039318 - Method and apparatus for transforming waste into fuel ethanol: The present invention describes substrates (feedstocks) used in the production of fuel ethanol and describes the process by which the alcohol is produced. The inventors process animal, vegetable, industrial food waste or a mixture of wastes in a process involving saccharification and fermentation reactions to produce a mixture of fuel... Agent: Chalney Singleton Chalker Flores, LLP
20110039319 - Enzyme recycle from hydrolysis of lignocellulosic material: A method to reduce enzyme usage for the break down of lignocellulosic material by enzymatic hydrolysis. Enzyme activity is retained and enzymes are recycled back for the hydrolysis of new lignocellulosic material after removal of fermentation products using low temperature distillation.... Agent: American Process Inc Steve Rutherford
20110039320 - Methods and compositions for enhanced production of organic substances from fermenting microorganisms: The present invention relates methods and compositions for producing an organic substance from fermenting microorganism using simultaneous saccharification and fermentation. One aspect of the invention provides producing alcohol by simultaneous saccharification and fermentation by combining a cellulosic substrate, and whole fermentation broth, and an ethanologenic microorganism under conditions conducive both... Agent: Danisco US Inc. Attention: Legal Department
20110039323 - Isoprene production: A method of producing isoprene is disclosed. In one embodiment, the method comprises the steps of obtaining a host transgenic microorganism and observing the production of isoprene by the microorganism. In another embodiment, the invention is a transgenic host microorganism for producing isoprene.... Agent: Quarles & Brady LLP
20110039322 - Method for producing biogas: The invention relates to a method for producing biogas, wherein biomass (B) is filled into a biogas reactor (R), and a plurality of mixing bodies (1) is disposed on the biomass (B). The mixing bodies (1) float on the surface (O) of the biomass (B) and thereby dip partially into... Agent: Browdy And Neimark, PLLC
20110039321 - Methods for the conversion of fish waste from aquaculture systems to methane via a modified uasb reactor: A process for treatment of sludge made up of saline organic solids or organic waste produced in a saltwater or brackish aquaculture system is described. The process includes use of a modified reactor, operating under anaerobic conditions, which yields methane from the digestion of the saline organic solids. Modification of... Agent: Intellectual Property / Technology Law
20110039324 - Compositions and methods for enhancing apoptosis: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.
20110039325 - Family 8 enzymes with xylanolytic activity: The present invention describes a method to improve the properties of a dough and/or a baked product by adding a bread or dough-improving agent containing a enzyme with xylanolytic activity belonging to glycoside hydrolases family 8. Preferred enzymes are the psychrophilic xylanase from Pseudoalteromonas haloplanktis and the mesophilic xylanase Y... Agent: Knobbe Martens Olson & Bear LLP
20110039326 - Biomass production system and apparatus: The present invention is a system for optimizing production of biomass. The system contains one or more growth modules under a shading element that diffuses light. Each of the growth modules has a plurality of vertical growth columns arranged on a bottom manifold. The biomass is grown within a liquid... Agent: Gunn, Lee & Cave, P.C.
20110039327 - Organic acid production by fungal cells: Improved systems for the biological production of organic acids are described.... Agent: Fish & Richardson P.C. (bo)
20110039328 - Tissue piece treating apparatus: The present invention can solve such a problem that a conventional tissue piece treating apparatus has difficulty of reduction in size and restriction on installation and stopping subsequent treatment operations when the amount of chemical supplied to a processing chamber is insufficient. The tissue piece treating apparatus comprises: new chemical... Agent: Blakely Sokoloff Taylor & Zafman LLP
20110039329 - Growth factor extractor: A reservoir is supported by a base in a vertical position. A reciprocating member is positioned in the reservoir forming an internal chamber. The chamber receives growth factor starting material through an inlet in the reciprocating member. After the inlet is sealed, the reciprocating member increases the volume of the... Agent: Price & Adams, P.C.
20110039330 - Animal cell culture media comprising non animal or plant derived nutrients: The present invention provides serum-free cell culture media formulations which are capable of supporting the in vitro cultivation of animal cells. The media comprise at least one nutrient of non-animal derivation, such as at least one plant peptide and/or at least one non-animal or plant lipid and/or fatty acid. The... Agent: Life Technologies Corporation C/o Intellevate
20110039331 - Tag peptide and use thereof: (wherein X1, X2 and X3 are the same or different and each represent any amino acid residue) and an antibody against the tag peptide. By combined use of the tag peptide and antibody of the present invention, a system that enables proteins expressed from cloned genes to be highly purified... Agent: Wenderoth, Lind & Ponack, L.L.P.
20110039333 - Defined conditions for human embryonic stem cell culture and passage: The invention relates to human pluripotent cells. More specifically, the invention provides a chemically defined xeno-free culture system that allows for long term expansion of human pluripotent cells. This culture system allows for human pluripotent cell lines to be maintained in the pluripotent state for an extended time while maintaining... Agent: Davis Wright Tremaine LLP/los Angeles
20110039332 - Human pluripotent stem cells induced from undifferentiated stem cells derived from a human postnatal tissue: To establish human pluripotent stem cells having properties close to human ES cells comprising the genome of the patient per se that can circumvent immunological rejection of transplanted cells from cells derived from a postnatal human tissue. It was found that human pluripotent stem cells can be induced by introducing... Agent: Wilson, Sonsini, Goodrich & Rosati
20110039334 - Chimeric oligomeric compounds for modulation of splicing: Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of... Agent: Knobbe, Martens, Olson & Bear, LLP
20110039335 - Compositions and methods for inhibiting cell migration: The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human breast cancers correlates with indicators of outcome: Dkk1 associates with markers of poor... Agent: Dla Piper LLP (us)
20110039336 - Product for cell culture: The present invention relates to a product for cell culture. In particular, the invention relates to a cell growth surface having a coating comprising an animal protein free coating. The coating is derived from an enzymatic hydrolysate of a plant protein, preferably soy peptone. The cell culture product is preferably... Agent: Ge Healthcare Bio-sciences Corp. Patent Department
20110039337 - Methods and devices for dispersing somatic plant embryos: Methods and devices for dispersion of clusters of somatic plant embryos suspended in a liquid are disclosed. The methods comprise i) subjecting the clusters of embryos to fluid dynamics forces causing axially extensional strain and radially compressional strain and ii) subjecting the clusters of embryos to fluid dynamics forces causing... Agent: Morrison & Foerster LLP
20110039338 - Method of efficiently establishing induced pluripotent stem cells: Provided is a method of improving the efficiency of establishment of induced pluripotent stem cells, comprising culturing somatic cells under hypoxic conditions in the step of nuclear reprogramming thereof.... Agent: Leydig Voit & Mayer, Ltd
20110039339 - Process, vectors and engineered cell lines for enhanced large-scale transfection: Processes vectors and engineered cell lines for large-scale transfection and protein production in mammalian cells, especially Chinese Hamster Ovary (CHO) cells are described in which transfection efficiencies are realized through the use of a single vector system, the use of functional oriP sequences in all plasmids, the use of codon-optimized... Agent: National Research Council Of Canada
20110039340 - Compositions and related methods for modulating transcriptional activation by incorporating gag motifs upstream of core promoter elements: Compositions and methods for genetically modifying the production levels of nicotine and other alkaloids in plants are provided. An expression vector which comprises a tripartite GAG motif is also disclosed.... Agent: Buchanan, Ingersoll & Rooney PC02/10/2011 > patent applications in patent subcategories. patent applications/inventions, industry category
20110033842 - skin sampling kit which stores nucleic acids in stable status, genetic test methods by using the kit and their practical application: The present invention relates to a new skin gene card for genetic test, a method for acquiring DNA and RNA and performing various genetic tests using the same, and practical applications thereof. More specifically, the inventors of the present invention have developed a skin gene card capable of acquiring samples... Agent: Hodgson Russ LLP The Guaranty Building
20110033837 - Immortalized human cd4-positive cell and its use for determining the phenotype of a human immunodeficiency virus type 1: The invention relates to an immortalized CD4-positive cell. According to the invention, this cell comprises a gene encoding a CXCR4 chemokine receptor that is capable of serving as a coreceptor for entry of a Human Immunodeficiency Virus Type 1 (HIV-I) into the cell, and a gene encoding a CCR5 receptor... Agent: David S. Resnick
20110033841 - Methods and kits for diagnosis, prognosis or monitoring of epstein-barr virus (ebv)-associated cancer: Disclosed is a non-invasive method for diagnosis, prognosis or monitoring of Epstein-Barr virus (EBV)-associated cancer by detecting and/or quantifying EBV associated nucleic acid fragments in a urine sample from an individual. Kits for diagnosis, prognosis or monitoring of cancer are also disclosed.... Agent: Seed Intellectual Property Law Group PLLC
20110033836 - Methods for determining the presence of antibodies blocking viral infection: The present invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient infected by the virus; (b) co-transfecting into a first cell (i) the nucleic acid of step (a),... Agent: Laboratory Corporation Of America Holdings C/o Kilpatrick Stokton LLP
20110033839 - Methods of detecting signatures of disease or conditions in bodily fluids: Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having cancer are also provided. Methods and compositions for diagnosing the presence of an infectious agent in an individual and/or for identifying an... Agent: Banner & Witcoff, Ltd.
20110033838 - Surface antigen protein mutant of hepatitis b virus surface antigen: The disclosure relates, in some embodiments, to sequences of a novel mutant or variant of the hepatitis B surface antigen (HBsAg) and methods for detecting this genome and protein variant, and antibodies directed against it, from patients' samples.... Agent: King & Spalding LLP
20110033840 - Viral detection liposomes and method: A method of generating pathogen detecting liposomes includes a step of providing molecular beacons with fluorescing components. The molecular beacons include either strands of RNA or DNA and the fluorescing components include an emitter and a quencher. The method further uses nanodroplet technology to encapsulate the molecular beacons within a... Agent: Robert A. Parsons
20110033850 - Compositions and methods for the identification of inhibitors of retroviral infection: Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed.... Agent: Myers Bigel Sibley & Sajovec
20110033846 - Concurrent analysis of multiple patient samples using solid phase addressable multiplex test with high signal-to-noise ratio: Contemplated systems and methods allow analysis of multiple and distinct patient samples using a labeling scheme that entirely avoids carry-over of a label or reagent to the analytic platform, typically an addressable solid phase. In preferred aspects, a hybridization portion, a fluorophore, and/or a quencher are removed by a 5′-3′-exonuclease... Agent: Fish & Associates, PC Robert D. Fish
20110033853 - Csnks as modifiers of the rac pathway and methods of use: Human CSNK genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of CSNK are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP
20110033848 - Epigenetic methods: The present invention provides methods for obtaining epigenetic information for a polyploid subject, the method including the steps of obtaining a biological sample from the subject, the sample containing: (i) at least one paternally-derived DNA molecule and/or associated protein and/or, (ii) at least one maternally-derived DNA molecule and/or associated protein,... Agent: Foley And Lardner LLP Suite 500
20110033861 - Method for diagnosing spinal muscular atrophy: A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a universal multiplex PCR using the nucleotide as a template and... Agent: Pai Patent & Trademark Law Firm
20110033843 - Method for in vitro testing of compounds for assessing therapeutic value in the treatment of multiple sclerosis and other diseases wherein foamy cells are involved in the disease etiology: The invention provides a method for assessing or determining activity of a test Compound on modulation of gene product levels comprising culturing cells, contacting at least one of the cultured cells with a lipid-rich fraction, contacting at least one of the cultured cells with the test Compound, determining the presence... Agent: Traskbritt, P.C.
20110033855 - Method for quantifying target nucleic acid molecules and kit for quantifying target nucleic acid molecules: The present invention is to provide a method for highly sensitively and precisely quantifying nucleic acid molecules in a sample. The method for quantifying target nucleic acid molecules in a nucleic acid-containing sample comprises: (a) preparing a sample solution comprising a nucleic acid-containing sample, a first nucleic acid molecule probe... Agent: Scully Scott Murphy & Presser, PC
20110033860 - Method for searching target base sequence of rna interference, method for designing base sequence of polynucleotide for causing rna interference, method for producing double-stranded polynucleotide, method for inhibiting gene expression, base sequence pro: e
20110033854 - Methods and compositions for long fragment read sequencing: The present invention is directed to methods and compositions for long fragment read sequencing. The present invention encompasses methods and compositions for preparing long fragments of genomic DNA, for processing genomic DNA for long fragment read sequencing methods, as well as software and algorithms for processing and analyzing sequence data.... Agent: Morgan, Lewis & Bockius, LLP (sf)
20110033845 - Methods for amplification of nucleic acids using spanning primers: The teachings relate to methods and kits for detecting whether target nucleic acid sequences are present and/or quantitating target nucleic acid sequences.... Agent: Life Technologies Corporation C/o Intellevate
20110033862 - Methods for cell genotyping: Methods for cell genotyping are disclosed herein. A method for determining the genomic data of one or a small number of cells, or from fragmentary DNA, where a limited quantity of genetic data is available may include adding one or more targeted primers to a whole genome amplification of a... Agent: Greenberg Traurig, LLP
20110033847 - Methods for the characterization of microorganisms on solid or semi-solid media: The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic... Agent: Biomerieux Vitek Inc.
20110033856 - Methods relating to aromatase inhibitor pharmacogenetics: Methods for aiding in determining therapeutic efficacy of an aromatase inhibitor in a subject are provided according to embodiments of the present invention which include detecting expression and/or function of at least one UDP-glucuronosyltransferase having activity to modify at least one aromatase inhibitor and/or metabolite of the aromatase inhibitor by... Agent: Julie K. Staple Gifford, Krass, Sprinkle, Anderson & Citkowski, P.
20110033865 - Novel method for diagnosing pregnancy-related complications: A method for diagnosing pregnancy-related complications in a pregnant woman is provided. The method includes the following steps: (a) determining the level of Placental Protein 17 (PP17) in a bodily substance obtained from the pregnant woman; and (b) comparing the determined level of PP17 to a standard level of PP17,... Agent: The Nath Law Group
20110033851 - Nucleic acid amplification: Provided herein is a method for the selective amplification of a target nucleotide sequence located within a nucleic acid molecule, the method comprising contacting the nucleic acid molecule (“template” molecule) with (i) at least one facilitator oligonucleotide, wherein the facilitator oligonucleotide includes at least one modification at or near its... Agent: Townsend And Townsend And Crew, LLP
20110033849 - Ovine identification method: The invention relates to method for identifying an ovine with a genotype indicative of one or more altered performance traits, the method including the step of detecting, in a sample derived from the ovine, the presence of at least one allele of the CP34 simple sequence repeat (SSR) marker, or... Agent: Pfizer Inc Mary J Hosley
20110033857 - Peptide sequence that promotes tumer invasion: An isolated sequence SGSSEEKQNAVSSEET (OPNcPEP) SEQ ID NO: 8, and uses thereof. The peptide enhanced soft agar clone formation but did not support the growth of cells in plastic dishes, consistent with supporting anchorage-independence rather than growth. This sequence represented and is unique for a domain around the splice junction... Agent: Thompson Hine L.L.P. Intellectual Property Group
20110033852 - Present invention relates to methods for prediction of the therapeutic success of breast cancer therapy: The present invention relates to a method for predicting a clinical response of a patient suffering from or at risk of developing gynecologic cancer towards a given mode of treatment, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the expression level of... Agent: Harness, Dickey & Pierce, P.L.C
20110033864 - Proliferative disease detection method: In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological... Agent: Birch Stewart Kolasch & Birch
20110033863 - Rna-selective hybridization reagent and use of the same: Provided is a nucleoside derivative which has a high affinity for RNA. Use is made of a nucleoside derivative represented by either formula (1) or formula (2). (In formulae (1) and (2), Z represents a carbon atom or a nitrogen atom; R1 represents a hydrogen atom or a hydroxyl-protecting group;... Agent: Oliff & Berridge, PLC
20110033859 - Rnai inhibition of influenza virus replication: The invention relates to compositions and methods for modulating the expression of influenza viral genes, and more particularly to the downregulation of influenza viral genes by chemically modified oligonucleotides.... Agent: Dt Ward, PC
20110033858 - Sirna detection method: PolydG is added to the terminal overhangs of an siRNA. Next, a primer containing a polydC sequence added with a tag sequence is annealed and cDNA is synthesized by a reverse transcription reaction. Quantitative PCR is performed between a primer carrying the same sequence as the tag sequence, and a... Agent: Banner & Witcoff, Ltd.
20110033844 - Use of lysosomal carboxypeptidase c (prcp) as a therapeutic or diagnostic target: The invention provides a human PRCP which is associated with the cardiovascular diseases, hematological diseases, neurological diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases and cancer. The invention also features compounds which... Agent: Edwards Angell Palmer & Dodge LLP
20110033869 - Enzyme triggered redox altering chemical elimination (e-trace) immunoassay: The present invention is directed to electronic methods of detecting target analytes such that upon binding of the target analyte a shift in electrochemical potential is seen. This assay relies on the use of an electroactive moiety (“EAM”) that is attached to an electrode and comprises a self-immolative moiety, whose... Agent: Morgan, Lewis & Bockius, LLP (sf)
20110033870 - Hybridoma producing antibodies to lawsonia intracellularis: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation
20110033872 - Method and apparatus for detecting undesired measurement conditions: The invention relates to a method and apparatus for detecting undesired measurement conditions in a sample container. The method comprises measuring a fluorescent property of the sample container comprising a sample substrate with impregnated blood sample and incubation buffer to which the blood sample is to be eluted, and determining,... Agent: Seppo Laine Oy Joshua P. Wert
20110033871 - Method for the determination of trichinella infections and diagnostic composition for such methods: Method for the determination of Trichinella infections in an animal or a human, comprising the incubation with Trichinella antigens of a tissue sample taken from the animal or the human, the processing of the tissue sample, the addition of anti-antibodies to the tissue sample, and the verification of whether binding... Agent: Rankin, Hill & Clark LLP
20110033866 - Resonance energy transfer assay with cleavage sequence and spacer: A molecular construct comprises a donor label, an acceptor label, a linker peptide disposed between the donor and the acceptor, the linker having a cleavage site sequence, and a spacer between at least one of (a) the donor and the cleavage site sequence and (b) the acceptor and the cleavage... Agent: Fish & Associates, PC Robert D. Fish
20110033868 - Use of a nitrated protein or peptide sequence for the implementation of a method of diagnosis: The present invention relates to the use of quantitative assay, in particular in vitro, in a biological sample, of the degree of nitration of tyrosine residues of a particular nitrated protein or physiological peptide sequence, for the implementation of a method of in vitro diagnosis of the state of severity... Agent: Young & Thompson
20110033867 - Use of biomarkers for detecting ovarian cancer: The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a... Agent: Edwards Angell Palmer & Dodge LLP
20110033874 - Biomarkers: The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring ANP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection. Also provided... Agent: Duane Morris LLP - San Diego
20110033875 - Glycoprotein cancer biomarker: The invention relates to glycoproteins having a cancer-specific glycoform. Cancer-specific glycoforms are useful in diagnostics and therapeutics.... Agent: Mueting, Raasch & Gebhardt, P.A.
20110033873 - Proteinic marker for early diagnosis of liver cancer: The present invention relates to proteomic markers for early detection of hepatocellular carcinoma, compositions for detecting changes of these proteomic markers, kits for detection of hepatocellular carcinoma, methods for detecting proteomic markers including these compositions, methods for screening drugs for hepatocellular carcinoma using these proteomic markers, and antibodies specific for... Agent: Nixon Peabody, LLP
20110033876 - Method for diagnosing pulmonary artery hypertension: The invention relates to an in vitro method for detecting pulmonary arterial hypertension (PAHT), or the risk of developing PAHT, which includes determining the presence and/or amount of anti-tenascin C antibodies in a biological sample from a patient.... Agent: Occhiuti Rohlicek & Tsao, LLP
20110033877 - Method for evaluation or selection of adiponectin secretion regulator: The method for evaluating or selecting an adiponectin secretion regulator includes the following steps (A) to (C): (A) a step of administering a test substance to an experimental animal; (B) a step of inducing a sleep deprivation in the experimental animal; and (C) a step of measuring blood adiponectin level... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20110033878 - Luminescent substrate for liciferase: The present invention relates to a compound having a structure analogous to firefly luciferin. In particular, the invention relates to a heterocycle compound which produces a luminescence at a light wavelength different from that of firefly luciferin in nature. The present invention provides a heterocycle compound of following general formula... Agent: Edwards Angell Palmer & Dodge LLP
20110033879 - Direct assay of cholesterol in skin removed by tape stripping: Skin cholesterol is measured by applying an adhesive tape onto a selected area of the skin to adhere the tape to the selected skin area and stripping the tape off the selected skin area to obtain a sample representative of the outer stratum corneum layer of the skin, the sample... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.
20110033880 - Fad-conjugated glucose dehydrogenase gene: An object of the present invention is to provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties that it has excellent reactivity to glucose, excellent thermal stability, and excellent substrate-recognition performance and also has a low activity for maltose; a process for the production of the... Agent: Wenderoth, Lind & Ponack, L.L.P.
20110033881 - System for detecting microbial contamination: The present invention relates to a system for detecting microbial contamination of a liquid specimen comprising a device for concentrating micro-organisms from a liquid specimen, having (i) a hyperbaric chamber, (ii) a filter housing comprising a liquid-permeable bed of an adsorbent material and adapted for being fluidly connected to said... Agent: Hoffmann & Baron, LLP
20110033882 - Variants of the bacillus licheniformis alpha-amylase: Variants of B. licheniformis alpha-amylase advantageously exhibit improved enzymatic performance. Suitable variants include those with an altered charge distribution on the surface of the enzyme or with altered active site residues. Structural modeling can inform the choice of amino acid modifications so that modified amino acids correspond to residues found... Agent: Danisco US Inc. Attention: Legal Department
20110033886 - Gdf-15 as biomarker in type 1 diabetes: The present invention relates to a method of predicting if a diabetes type 1 patient will suffer from one or more complications selected from cardiovascular complications, terminal renal failure, and death, the method including (a) determining the amount of GDF-15 in a sample of a diabetes type 1 patient; and... Agent: Roche Diagnostics Operations Inc.
20110033883 - Imaging dyes and use thereof: Use of a metal complex having the formula: [M(L1)a(L2)b(L3)c]-Xd-Pepe wherein M is a metal selected from osmium, ruthenium, rhodium, rhenium or copper; L1, L2, L are bidentate or tridentate heterocyclic ligands containing O and/or N and may be the same or different; a, b, c are integers between 0 to... Agent: Jacobson Holman PLLC
20110033885 - Method for manufacturing a tissue-engineered construct: Method for manufacturing a tissue-engineered construct, such as a heart valve, comprising the steps of providing a-cell-seeded scaffold in a bioreactor chamber which bioreactor chamber is divided by the cell-seeded scaffold into a first compartment and a second compartment, subjecting the cell-seeded scaffold to a flow of nutrient medium within... Agent: Barnes & Thornburg LLP
20110033884 - Pd-1, a receptor for b7-4, and uses therefor: Disclosed is a method for modulating an immune response by modulating signaling via PD-1. The immune response may be downregulated by increasing signaling via PD-1, or may be upregulated by decreasing signaling via PD-1. Agents which are useful for stimulating signaling via PD-1 to downregulate an immune response include an... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20110033888 - Method for producing sweet juice from lignocellulosic biomass with improved enzyme recycle: The present invention relates to a method of producing sweet juice from lignocellulosic substrate, wherein enzymatic hydrolysis is carried out by performing cellulase supplementation with supported β-glucosidases used in a reactor separate from the lignocellulose enzymatic hydrolysis reactor.... Agent: Millen, White, Zelano & Branigan, P.C.
20110033887 - Three-dimensional microfabricated bioreactors with embedded capillary network: In an aspect, the present invention uses projection micro stereolithography to generate three-dimensional microvessel networks that are capable of supporting and fostering growth of a cell population. For example, provided is a method of making a microvascularized bioreactor via layer-by-layer polymerization of a photocurable liquid composition with repeated patterns of... Agent: Greenlee Sullivan P.C.
20110033889 - Apparatus and method for hydrolysis of a protein containing raw material and application of the resulting hydrolysis products: Apparatus and methods for hydrolyzing protein-containing raw material into water soluble protein and other products. The apparatuses and methods comprise an optional collection or processing stage in which protein-containing raw material, such as fish or animal carcasses from food production plants, are collected and optionally processed. The raw material is... Agent: Baker & Daniels LLP
20110033890 - Method for the secretory production of heterologous protein in escherichia coli: The present invention relates to a signal sequence peptide for the improvement of extracellular secretion efficiency of a heterologous protein in E. coli. More particularly, the present invention relates to a gene construct for the improvement of extracellular secretion efficiency of the said heterologous protein in E. coli, which comprises... Agent: Greenlee Sullivan P.C.
20110033891 - Mussel bioadhesive: The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a hybrid of MGFP-5 and foot protein type 1 (FP-1), where an adhesive protein with adhesive activity can be economically... Agent: Jhk Law
20110033892 - Novel members of the capsaicin/vanilloid receptor family of proteins and uses thereof: The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors... Agent: Banner & Witcoff, Ltd.
20110033893 - Improved methods for protein production: Methods for low cell-density bacterial protein expression that can achieve levels of up to 180 mg/l using a simple and low cost strategy. Full codon optimization is unnecessary to improve expression of viral genes rich in E. coli rare codons. Using a strategically modified host cell provides a simpler and... Agent: Sheridan Ross PC
20110033894 - Engineering surface epitopes to improve protein crystallization: Methods and systems for engineering surface epitopes, based on protein sequence characteristics with statistically significant influence on the likelihood of x-ray structure solution, to improve protein crystallization, as well as related material, are disclosed.... Agent: Wilmerhale/columbia University
20110033896 - Method for manufacturing an aqueous glucose solution from plants of the triticeae species: The present invention relates to a method for manufacturing an aqueous glucose solution from the starch components of Triticeae grains, for example from rye, triticale or in particular wheat grains. The invention also relates to a glucose-based fermentation method for manufacturing organic compounds in which the glucose manufactured for fermentation... Agent: Connolly Bove Lodge & Hutz, LLP
20110033895 - Method for producing human antibodies with properties of agonist, antagonist, or inverse agonist: A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of... Agent: Bacon & Thomas, PLLC
20110033897 - Method for the obtainment of hydrolytic enzymes, hydrolytic method for producing fermentable sugars, additives comprising fermentable sugars, and process for producing ethanol from sugar cane bagasse: The present invention provides industrial methods involving the hydrolysis of sugar cane bagasse, including methods for producing hydrolytic enzymes, for hydrolysis of sugar cane bagasse, for the production of additives comprising fermentable sugars and the respective additives, and methods of producing ethanol. The invention methods comprised the submerged culture of... Agent: Smith, Gambrell & Russell
20110033898 - Method for producing 5'-guanylic acid: 5′-guanylic acid (GMP) is produced efficiently by allowing a microorganism to react with xanthylic acid (XMP), wherein said microorganism is able to convert xanthylic acid into 5′-guanylic acid and has been modified so that the nagD gene does not function normally and 5′-guanylic acid synthetase activity is enhanced.... Agent: Cermak Nakajima LLP Acs LLC
20110033899 - Convection polymerase chain reaction method: The invention relates to a method for rapid detection of specific nucleic acid fragments with the aid of a PCR, consisting in amplifying target products in a special DNA thermocycler, provided with a special reaction thermal unit, which makes it possible to obtain, in reaction vessels in the form of... Agent: Seed Intellectual Property Law Group PLLC
20110033900 - Trichoderma reesei glucoamylase and homologs thereof: The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for the glucoamylases, vectors and host cells incorporating the DNA sequences,... Agent: Danisco US Inc. Attention: Legal Department
20110033901 - Compositions of and methods of using sulfatases from flavobacterium heparinum: This invention is related, in part, to sulfatase enzymes and methods of their use.... Agent: Wolf Greenfield & Sacks, P.C.
20110033902 - l-cysteine-producing bacterium and a method for producing l-cysteine: (b) a protein comprising the amino acid sequence of SEQ ID NO: 2, but wherein one or several amino acid residues are substituted, deleted, inserted or added, increase of which activity in the bacterium improves the ability of the bacterium to produce L-cysteine.... Agent: Cermak Nakajima LLP Acs LLC
20110033903 - Isolated population of plant single cells and method of preparing same: This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from cambium to promote the stability of the plant-derived biologically active substances production by solving the... Agent: Edwards Angell Palmer & Dodge LLP
20110033904 - Method for preparing orthodihydroxyisoflavones using a biotransformation system: Disclosed herein is a method for preparing ortho-dihydroxyisoflavones using a biotransformation system. More specifically, disclosed is a method for preparing ortho-dihydroxyisoflavones, which comprises biotransforming daidzein or genistein by actinomycete microorganisms, particularly Streptomyces avermitilis, Nocardia farcinica or Streptomyces lincolnesis, in order to efficiently prepare ortho-dihydroxyisoflavones having an excellent antioxidant function and... Agent: Nixon & Vanderhye, PC
20110033905 - Process for producing optically-active ortho-substituted mandelic acid compound: The present invention provides a process of asymmetrically reducing an ortho-substituted phenylglyoxalic acid compound to produce a corresponding optically-active ortho-substituted mandelic acid compound by using a microorganism having an ability of reducing the ortho-substituted phenylglyoxalic acid compound into the optically-active ortho-substituted mandelic acid compound, or a treated product thereof.... Agent: Sughrue Mion, PLLC
20110033906 - Method for producing useful substance from cellulose-containing material: The present invention provides a method for producing a useful substance efficiently from cellulose without using any cellulase preparation. According to the disclosures of the present specification, in the production of a useful substance from a cellulose-containing material, the cellulose-containing material is brought into contact with an ionic liquid to... Agent: Oliff & Berridge, PLC
20110033907 - Yeast strains for improved ethanol production: Novel strains of yeast and methods for improved ethanol production utilizing the yeast strains are disclosed. In particular, the novel yeast strains Saccharomyces cerevisae YE1358 and YE1615 provide for increased fermentation temperature tolerance, as well as tolerance to increased levels of glucose and ethanol, and thereby provide increased ethanol production... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.
20110033908 - Methods for selectively producing hydrogen and methane from biomass feedstocks using an anaerobic biological system: The present invention provides a method for selective production of hydrogen and methane from a biomass feedstock in a reactor vessel maintained under anaerobic conditions by controlling moisture concentration in the reactor vessel. The method comprises the steps of introducing a biomass feedstock into the reactor vessel maintained under anaerobic... Agent: Goodwin Procter LLP Patent Administrator
20110033909 - Means and methods for cloning nucleic acid sequences: The invention provides means and methods for efficiently cloning nucleic acid sequences of interest in micro-organisms that are less amenable to conventional nucleic acid manipulations, as compared to, for instance, E.coli. The present invention enables high-throughput cloning (and, preferably, expressing) of a nucleic acid of interest in a first kind... Agent: Reed Smith LLP
20110033910 - Cell selection apparatus, and cell selection method using the same: The cell selection apparatus includes: a cell selection vessel which has a pair of electrodes and a sheet-like insulating material having a plurality of micropores, with a recognition molecule bindable to the specific substance being disposed on a bottom face of the micropore; and a power supply, wherein the power... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110033911 - Episomal fusion gene: The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and... Agent: Foley And Lardner LLP Suite 500
20110033912 - Photobioreactor and a process for enhancing growth of photosynthetic organisms: A photobioreactor apparatus in which a reaction chamber contains a slurry of water, nutrients and photosynthetic organisms. The sidewall of the reaction chamber is constructed of translucent material, thereby permitting light to be conveyed into the slurry to promote photosynthesis. The interior of the reaction chamber is in fluid communication... Agent: Law Offices Of Mark E Wiemelt, PC
20110033913 - Photobioreactor and a process for enhancing growth of photosynthetic organisms: The present invention relates to microorganisms able to reduce mercury ion to metallic mercury; in particular, it refers to systems, apparatuses such as a stirred bioreactor and methods for microbiological mercury removal from contaminated materials, such as, e.g., contaminated environmental matrices, like soil and sediments. The contaminated material is mixed... Agent: Beusse Wolter Sanks Mora & Maire
20110033914 - In vitro model of latent mycobacterial infection: A method of inducing latency in Mycobacterium permits preparation of an in vitro model system of latent mycobacterial infection. Latency is induced in a pure culture of Mycobacterium by exposing it to multiple stress conditions, including a low nutrient culture medium without glycerol, a low pH, a relatively high level... Agent: Allen, Dyer, Doppelt, Milbrath & Gilchrist, P.A.
20110033915 - In vitro model of latent mycobacterial infection: A method of inducing latency in Mycobacterium permits preparation of an in vitro model system of latent mycobacterial infection. Latency is induced in a pure culture of Mycobacterium by exposing it to multiple stress conditions, including a low nutrient culture medium without glycerol, a low pH, a relatively high level... Agent: Allen, Dyer, Doppelt, Milbrath & Gilchrist, P.A.
20110033916 - Organ transport container system: An organ transport container system for storing and transporting therein an organ coupled to a perfusion system for preserving the viability of the organ for implantation by perfusing the organ with a perfusion liquid. The container system includes a cartridge for carrying the organ and a receptacle for holding a... Agent: Pearne & Gordon LLP
20110033917 - Sensor with long-term stability for bioprocesses: A sensor for registering a measured variable of a medium, especially in a bioprocess. The sensor includes a sensor body, wherein at least one surface section of the sensor body can be supplied with the medium, and wherein a condition of this surface section affects the measured value. The sensor... Agent: Bacon & Thomas, PLLC
20110033918 - Rotating bioreactor: Articles and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. In some embodiments, a bioreactor is configured to provide a first and second chamber, such as an inner and an outer chamber, respectively. The chambers may be co-axially arranged with respect to each other. A... Agent: Wolf Greenfield & Sacks, P.C.
20110033919 - Method of reducing temperature difference between a pair of substrates and fluid reaction device using the same: A method of reducing a temperature difference between a high-temperature and a low-temperature substrate includes interposing a heat transfer facilitating layer which has a higher thermal conductivity than air and can hold particles between the substrates, and maintaining close contact between the high-temperature substrate, the heat transfer facilitating layer, and... Agent: Cantor Colburn LLP
20110033921 - Bardet-biedl susceptibility gene and uses thereof: The present invention relates to the identification of a gene, now designated negevin (ngvn), that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. The human NGVN protein... Agent: Fulbright & Jaworski L.L.P.
20110033920 - Compositions and methods for use in recombinational cloning of nucelic acids: The present invention relates generally to compositions and methods for use in recombinational cloning of nucleic acid molecules. In particular, the invention relates to nucleic acid molecules encoding one or more recombination sites or portions thereof, to nucleic acid molecules comprising one or more of these recombination site nucleotide sequences... Agent: Life Technologies Corporation C/o Intellevate
20110033924 - Apparatus and method for filtering biological material: A method and apparatus for harvesting cells from a fluid so as to preserve the integrity of the cells when used in the diagnosis of cancer. The apparatus comprises a filter adapted to collect cells of a predetermined size, a fluid pathway arranged to transmit fluid to and from the... Agent: Morgan, Lewis & Bockius LLP (sf)
20110033925 - Cell separation method and apparatus: Disclosed herein are apparatus and methods for isolating a fraction of interest from a physiological fluid sample.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20110033923 - Marker for stem cells and its use: A marker for mesenchymal stem cells (MSC) is provided, comprising an integrin alpha10 chain and/or an integrin alpha11 chain expressed on the cell surface of or intracellular in a MSC. The marker is used in methods for identification of mammalian MSC and in methods for isolation of MSC. Also included... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20110033922 - Microchip-based acoustic trapping or capture of cells for forensic analysis and related method thereof: The present invention provides a method and apparatus for separating by size a mixture of different size particles using ultrasound. The apparatus contains a microchannel having an acoustic transducer thereon. As a mixture of cells having different sizes flows down the microchannel, the ultrasonic radiation traps cells of desired sizes... Agent: Schwegman, Lundberg & Woessner, P.A.
20110033926 - Production of viral vectors: The present invention relates to methods and compositions for the production of viral vectors. In particular, the present invention provides methods and compositions for faster, higher titer and higher purity production of viral vectors (e.g. adenoviral vectors). In some embodiments, the present invention provides gutted and helper viruses with identical... Agent: Medlen And Carroll, LLP Suite 350
20110033927 - Methods of generating small-diameter tissue engineered blood vessels: Methods for generating small diameter tissue engineered blood vessels through direct cell seeding onto tubular templates or mandrels, such as fibrin microthreads or collagen-coated silicon tubes, are described.... Agent: Burns & Levinson, LLP
20110033928 - Methods and compositions for growth of cells and embryonic tissue on a synthetic polymer matrix: The present invention provides methods and compositions for establishing and maintaining growth of cells and embryonic tissue on a synthetic polymer matrix. For example, the present invention provides synthetic growth matrices for stem cells, gametes, mature differentiated cells, and embryonic tissue (e.g., blastomeres, embryos, and embryoid bodies). In certain embodiments,... Agent: Casimir Jones, S.c.
20110033930 - Method for obtaining ngn3-expressing cells and insulin producing-beta cells: The present invention relates to a method for obtaining Ngn3-expressing cells and insulin producing-beta cells by contacting a Pdx1-expressing pancreas explant with an amount of at least one histone deacetylase inhibitor (HDACi). The inventive methods have the advantage of being simple and quick, and of providing large amounts of Ngn3-expressing... Agent: Whitham, Curtis & Christofferson & Cook, P.C.
20110033929 - Uses of antibodies to mammalian dc langerhans cell antigen: The present invention relates to purified mammalian DC cell surface protein, designated Langerin, nucleic acids encoding Langerin, and antibodies which specifically bind Langerin.... Agent: Merck Patent Department (k-6-1, 1990)
20110033931 - De-differentiation of human cells: Methods of de-differentiating somatic cells to an embryonic stem cell state comprising direct delivery of a protein into the somatic cell, wherein the protein effects de-differentiation of the somatic cell to an embryonic stem cell phenotype.... Agent: Knobbe Martens Olson & Bear LLP
20110033933 - Method applying hemodynamic forcing and klf2 to initiate the growth and development of cardiac valves: A method for forming a cardiovascular structure in culture is provided. The method includes applying mechanical force to a cell population in culture such that a cardiovascular structure is formed. In some embodiments, the mechanical force is produced in culture medium by a pulsatile liquid flow with a retrograde component.... Agent: Berliner & Associates
20110033932 - Substrate for cell adhesion or culture and method for producing the same: A substrate for cell adhesion or culture of the invention comprises: a base material; a cell adhesion layer arranged to cover a predetermined region on this base material; and a non-cell adhesion layer arranged on the base material to cover a region other than the predetermined region. An exposed surface... Agent: Grossman, Tucker, Perreault & Pfleger, PLLC
20110033936 - Canine ips cells and method of producing same: Provided are a method of producing canine iPS cells, comprising (a) the step of bringing into contact with each other a canine somatic cell and a nuclear reprogramming factor, and (b) the step of culturing the cell in a medium containing at least one substance selected from the group consisting... Agent: Leydig Voit & Mayer, Ltd
20110033935 - Rationally-designed meganucleases with recognition sequences found in dnase hypersensitive regions of the human genome: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment... Agent: Wilmerhale/boston
20110033934 - Transcriptome transfer produces cellular phenotype conversion: The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.... Agent: Riverside Law LLP
20110033937 - Down-regulation of gene expression using artificial micrornas: Isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression are described.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110033938 - System for inducible gene expression in chlamydomonas: The unicellular green alga Chlamydomonas reinhardtii is currently used in many biotechnological applications for the production of biopharmaceuticals and of biohydrogen. These applications require the tightly controlled expression of genes. The present invention consists in the development and use of gene cassettes and culture growth media to obtain inducible, reversible... Agent: Nixon & Vanderhye, PC02/03/2011 > patent applications in patent subcategories. patent applications/inventions, industry category
20110027771 - Methods and compositions for cell stabilization: Fragile cells have value for use in diagnosing many types of conditions. There is a need for compositions that stabilize fragile cells. The stabilization compositions of the provided invention allow for the stabilization, enrichment, and analysis of fragile cells, including fetal cells, circulating tumor cells, and stem cells.... Agent: Wilson, Sonsini, Goodrich & Rosati
20110027772 - Antigen detection kit and method: An antigen detection kit and an antigen detection method using the same are provided. The antigen detection kit comprises a capture antibody, a detection antibody bound to a single stranded DNA oligonucleotide, a single stranded RNA oligonucleotide complementary sequence to the DNA oligonucleotide, and an RNase.... Agent: LexyoumeIPGroup, PLLC
20110027775 - Detection of influenza virus: A change in strain of flu and consequently pandemic potential can be determined by assessing the presence or absence of a PL motif. The 2009 swine flu illustrates the utility of such a test. The swine flu is a subtype H1N1 influenza A. Swine flu differs from the vast majority... Agent: Townsend And Townsend And Crew, LLP
20110027774 - Highly sensitive method for detection of viral hiv dna remaining after antiretroviral therapy of aids patients: Methods for detecting polynucleotides, especially the DNA replicated from samples obtained from subjects infected with pathogenic viruses such as human immunodefiency virus, by detecting electromagnetic signals (“EMS”) emitted by such polynucleotides, and methods for improving the sensitivity of the polymerase chain reaction (“PCR”).... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110027773 - Mass spectrometric methods for detecting mutations in a target nucleic acid: Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided. In some embodiments, a process comprises: amplifying a nucleic acid from a biological sample; ionizing and volatilizing the amplified product; analyzing the product by mass spectrometry to determine an observed... Agent: Grant Anderson LLP C/o Portfolioip
20110027780 - Amplification methods: Methods are provided for amplification and monitoring of oligonucleotide amplification in which a primer has an overlap with one or more bases of a detection probe.... Agent: Jackson Walker LLP
20110027792 - Assay for mycobacterium avium/intracellulare nucleic acid: Disclosed is a method for determining the presence of Mycobacterium avium complex nucleic acids in a biological sample. In particular, the mig gene of M. avium and the DT1 gene of M. intracellulare are detected, preferably following amplification. In addition, the method distinguishes between species of M. avium and M.... Agent: Foley & Lardner LLP
20110027795 - Cell processing and/or enrichment methods: The present invention relates to methods of processing and/or enriching cells from a pregnant female. More particularly the invention provides methods for processing and/or enriching fetal cells from a pregnant female. The enriched fetal cells can be used in a variety of procedures including, detection of a trait of interest... Agent: Sheridan Ross PC
20110027778 - Composition comprising an oligonucleotide mixture for improved detection of human papillomavirus genotypes: The present invention relates to a composition comprising an oligonucleotide mixture. Moreover, the present invention relates to the use of said oligonucleotide mixture for diagnosing different HPV genotypes in a sample of a subject. Further encompassed is a method for diagnosing different HPV genotypes in a sample of a subject... Agent: Foley And Lardner LLP Suite 500
20110027783 - Exo1 promotor polymorphism associated with exceptional life expectancy in humans: The invention relates to an exonuclease 1 (EXO1) promoter polymorphism associated with exceptional life expectancy in humans. More specifically, the invention relates to the promoter region of EXO1 where the gene has been found to be mutated. Moreover, the invention relates to a gene regulation mechanism involving transcription factor E47... Agent: Diederiks & Whitelaw, PLC
20110027798 - Hybridization quantitation method for modified micro-rna and -dna based oligonucleotides: Described herein is a method for the qualitative and/or quantitative determination of an analyte in a test sample which includes base pairing at least one oligonucleotide to a capture template having an overhang; and, hybridizing with a detection probe.... Agent: Macmillan Sobanski & Todd, LLC
20110027799 - Kit and method for determining whether or not unmethylated cytosine conversion treatment is properly carried out and method for analyzing methylated dna using the same: Success or failure of unmethylated cytosine conversion treatment is determined by using a first primer set comprising plural primers that hybridize with a nucleic acid comprising a nucleotide sequence not containing cytosine in the nucleotide sequence of biological DNA that is subject to an unmethylated cytosine conversion treatment and a... Agent: Sughrue Mion, PLLC
20110027793 - Kit for measuring in vivo mutation frequency at an endogenous gene locus: The present invention relates a method for the enumeration of in vivo gene mutation. The method utilizes differential staining of GPI-anchor deficient erythrocyte populations to distinguish between wild-type and pig-a gene mutants. Quantitative analyses can be conducted on erythrocytes and/or reticulocytes, and is based upon fluorescent emission and light scatter... Agent: Nixon Peabody LLP - Patent Group
20110027776 - Kits and methods for assessing antioxidant requirement of a human: The invention relates to kits and methods for assessing the desirability of supplementing the diet of a human with reduced coenzyme Q (CoQH2). The methods involve assessing occurrence in the human's genome of the NQO1*2 polymorphism of the NQO1 gene. Occurrence of a copy of the polymorphism indicates that the... Agent: Thompson Hine L.L.P. Intellectual Property Group
20110027796 - Method for detecting lung cancer using lung cancer-specific methylation marker gene: The present invention relates to a method for detecting lung cancer using a lung cancer-specific biomarker, and more particularly to a biomarker for lung cancer diagnosis, which can detect methylation of PCDHGA12 gene whose 5′UTR or exon 1 region is specifically methylated in lung cancer cells, and to a method... Agent: Moore & Van Allen PLLC
20110027785 - Method for determining susceptibility of individuals to polyphenols: e
20110027791 - Method for generating single-stranded dna molecules representative of a dna sample: A method for generating a population of single stranded DNA molecules representative of a DNA sample, including digesting the DNA sample with a Type I restriction endonuclease; subjecting the DNA fragments to melt conditions to produce a melt-generated mixture of forward and reverse single stranded DNA fragments; contacting the mixture... Agent: Knobbe Martens Olson & Bear LLP
20110027777 - Method for performing prognosis for high-risk breast cancer patients using top2a gene aberrations: A first exemplary method for performing a prognosis for a breast cancer patient, comprises the steps of determining the status of an aberration of the TOP2A gene in a tissue sample taken from the patient; and estimating the probability of either recurrence-free survival or of overall survival of the patient... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20110027794 - Method for synthesizing nucleic acids, and application thereof: The invention relates to a method for synthesizing a nucleic acid containing modified nucleotides. The method encompasses the following steps: a matrix strand is provided; —a primer which at least partially hybridizes on the matrix strand is provided; —nucleoside triphosphates, at least some of which are modified nucleoside triphosphates, are... Agent: Mdip LLC
20110027797 - Method for the diagnosis of higher- and lower-grade astrocytoma using biomarkers and diagnostic kit thereof: Disclosed is a method of diagnosing the presence of higher grade astrocytoma/glioblastoma (GBM) or lower-grade grade astrocytoma (DA or AA) in a human subject using secreted or plasma membrane associated biomarkers, which involves the detection of the expression levels of said genes, alone or in combination, in either tumor tissue... Agent: Dla Piper LLP (us)
20110027787 - Methods and systems for identifying and isolating stem cells and for observing mitochondrial structure and distribution in living cells: Methods and systems for a) identifying and isolating stem cells, b) assessing mitochondrial distribution and structure in living cells and c) performing fluorescence microscopy on living cells while the cells remain within a condition-controlled cell culture chamber.... Agent: Stout, Uxa, Buyan & Mullins LLP
20110027789 - Methods for preservation of genomic dna sequence complexity: The present invention relates to methods and kits for preserving genomic DNA sequence complexity within chemically and/or enzymatically converted DNA by an enzyme or series of enzymes that adds a methyl group to a cytosine outside of CpG dinucleotide sequences of genomic DNA. Further, the present invention relates to methylation... Agent: Epigenomics Ag
20110027790 - Methods of equalizing representation levels of nucleic acid targets: The disclosure provides methods of reducing the range of representation levels of nucleic acid targets. The methods are particularly useful for multi-target analyses benefiting from a low variance of target representations, such as, e.g., single molecule sequencing and/or heterozygous genotyping, and pathogen diagnosis. Two general methods are provided. In Method... Agent: Brown Rudnick LLP
20110027784 - Novel primers for identification of astrocytoma, its grades and glioblastoma prognosis: The present invention relates to novel primers for identification of astrocytoma, it's grades and glioblastoma prognosis. Further, disclosed is a method of diagnosing the presence of different grades of diffuse astrocytoma and glioblastoma, in a human subject, which involves detection of the expression levels of said genes in tumor tissue... Agent: Fulbright & Jaworski L.L.P.
20110027779 - Polynucleotide primers: A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA... Agent: Fanelli Strain & Haag PLLC
20110027786 - Primers for nucleic acid extension or amplification reactions: Disclosed are methods and compositions for use in nucleic acid amplification or extension reactions.... Agent: Knobbe Martens Olson & Bear LLP
20110027782 - Probes and methods for detection of pathogens and antibiotic resistance: Described are probes and methods for detecting pathogens and antibiotic resistance of a specimen. The method comprises contacting the specimen with a growth medium; and lysing the specimen to release nucleic acid molecules from the specimen. The lysate of the specimen is contacted with a capture probe immobilized on a... Agent: Karen S. Canady Canady & Lortz LLP
20110027788 - Reagent and kit for classifying and counting leukocytes, the preparation thereof, and process for classifying and counting leukocytes: A reagent for classifying and counting leukocytes containing (1) a cyanine fluorescent dye; and (2) a glycoside compound; a reagent kit containing the reagent for classifying and counting leukocytes as well as its preparation process; and a process for classifying and counting blood cells using the reagent or kit are... Agent: Mindray C/o Stoel Rives LLP
20110027781 - System for autonomous monitoring of bioagents: An autonomous monitoring system for monitoring for bioagents. A collector gathers the air, water, soil, or substance being monitored. A sample preparation means for preparing a sample is operatively connected to the collector. A detector for detecting the bioagents in the sample is operatively connected to the sample preparation means.... Agent: Lawrence Livermore National Security, LLC
20110027800 - Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings: The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes.... Agent: Life Technologies Corporation C/o Intellevate
20110027805 - Acpl-related assays: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.... Agent: Immunex Corporation Law Department
20110027806 - Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis: Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called “progerin”) that alters... Agent: Klarquist Sparkman, LLP
20110027804 - Immune system modeling devices and methods: Devices and methods are provided for detecting an immune reaction to a test agent using an immune modeling system comprising a barrier component configured to culture a biological barrier, an immune component configured to culture immune cells, and one or more inter-component microfluidic connections between the barrier component and the... Agent: Wilson, Sonsini, Goodrich & Rosati
20110027807 - Protein specific to pancreatic beta cells in islets of langerhans and applications thereof: The invention relates to protein ZnT-8 which is specifically expressed in the pancreatic beta cells in islets of Langerhans, to a polynucleotide encoding said protein which is involved in the maturation and exocytosis of insulin, and to the applications thereof, for example, for sorting and studying beta cells and for... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110027809 - Method for evaluation of degree of malignancy of tumor cell: Disclosed is a method for evaluating the degree of malignancy of a tumor cell, which comprises: preparing a cell membrane fraction containing a receptor tyrosine kinase (RTK) from a sample containing the tumor cell; measuring the enzymatic activity of RTK in the cell membrane fraction in both the presence and... Agent: Sughrue Mion, PLLC
20110027808 - Methods and kits for detecting tumor-specific fusion proteins: The invention relates to the field of cancer diagnosis and the application of diagnostic techniques in pathology and hematology. Specifically, the invention relates to improved flow cytometric techniques, and kits related thereto, for the detection of chromosomal aberrations and the detection of tumor specific gene products exclusively expressed by tumor... Agent: Traskbritt, P.C.
20110027801 - Epha kinase cancer diagnostic: A method of detecting malignant progression of neoplastic cells in an animal includes obtaining a sample of neoplastic cells from the animal, determining a level of S897-EphA2 phosphorylation in the neoplastic cells of the samplem, and comparing the determined level of S897-EphA2 phosphorylation in the sample to a control value,... Agent: Tarolli, Sundheim, Covell & Tummino, LLP
20110027803 - Compositions and methods for maintenance of fluid conducting and containment systems: Latently detectable small molecules, or ‘labels’, used for monitoring of treatment substances in fluid conducting and containment systems. A composition comprising the treatment substance and the label, a method of manufacturing the composition, a method and kit for use in monitoring the treatment substances in a fluid conducting and containment... Agent: Ostrager Chong Flaherty & Broitman PC
20110027802 - Methods and kits for separation and detection of proteins in biological samples: Methods and kits are provided for separating a mixture of proteins in a biological sample. Methods for detecting and profiling proteins in biological samples by the separation method and kits are also provided. These methods are particularly useful in assessing damage to cells such as cardiac and skeletal muscle cells... Agent: Kathleen A. Tyrrell Licata & Tyrrell P.C.
20110027812 - Assay for antibodies to mycobacterium paratuberculosis: A method of detecting an immune response to a paratuberculosis-specific antigen, comprising incubating a sample from a subject with the paratuberculosis-specific antigen and detecting the presence of an antibody in the sample as an indication of an immune response to the paratuberculosis-specific antigen. The antigen may be obtained from a... Agent: Quarles & Brady LLP
20110027811 - Assay system for the assessment of oncogenicity, tumor progression, and treatment efficacy: Systems and kits are provided which are capable of determining the oncogenicity of a cancer, tumor progression, and effectiveness of a cancer treatment. Such systems and kits utilize assays to examine the levels of apoptotic markers, angiogenesis markers, immunomodulation markers, and cell cycle markers and can compare samples from a... Agent: Mccarter & English, LLP Boston
20110027810 - Chimeric recombinant antigens of toxoplasma gondii: The invention described herein relates to a method for combining antigen fragments of Toxoplasma gondii proteins, in the form of chimeric fusion products, and their use as diagnostic and immunogenic agents.... Agent: Steinfl & Bruno
20110027813 - Compositions for binding to assay substrata and methods of using: Compositions and methods for binding to assay substrata in a stable and protective manner, thereby enhancing assay performance, are provided. The compositions comprise lyotropic materials (for example, lyotropic liquid and/or liquid crystalline materials) and may contain macromolecular standards, markers or capture compounds. The compositions are capable of binding to assay... Agent: Whitham, Curtis & Christofferson & Cook, P.C.
20110027814 - Brca1 function-based cellular assays: Assays using binding studies involving function of BRCA1a protein have use for diagnosis and for evaluation of possible tumorogenicity of agents, particularly estrogenic agents. The assays do not rely on use of a probe for only specific sequences, but on effects of known and unknown or not previously studied sequences... Agent: Andrews Kurth LLP
20110027815 - Method of detecting isolevuglandin phospholipid adducts: A method of measuring isolevuglandin and/or levuglandin adducts associated with oxidative injury in a subject includes obtaining a bodily sample from a subject suspected of including isolevuglandin and/or levuglandin phospholipid adducts, hydrolyzing isolevuglandin and/or levuglandin phospholipid adducts from the sample with an enzyme that forms isolevuglandin and/or levuglandin phospholipid derivatives,... Agent: Tarolli, Sundheim, Covell & Tummino, LLP
20110027816 - Biosensor system, sensor chip, and method of measuring analyte concentration in blood sample: The present invention provides a biosensor system that can prevent a measurement error caused by the temperature of the environment in use from occurring. A biosensor system 100 includes a measuring instrument 101 having an operation part 306, and a sensor chip 200 that is insertable into and removable from... Agent: Hamre, Schumann, Mueller & Larson P.C.
20110027818 - Apparatus and method for detecting zinc ions: The present invention provides apparatuses and methods for determining zinc ion concentration in a fluid sample. Some apparatuses of the invention include (i) a light source designed to emit an excitatory light at a first known wavelength that activates a fluorescent emission having a second and different wavelength by at... Agent: Don D. Cha
20110027820 - Engineering enzymes through genetic selection: The embodiments of the present disclosure provide a versatile system, and methods of using, that allow for the selection of variant nuclear receptor ligand binding domains, or for the selection of variant enzymes, or combinations thereof, that may have an enhanced ability to synthesize a nuclear receptor ligand or a... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP
20110027821 - Method of bioassaying yokukansan: The invention intends to find out a bioassay system with an in-vitro test capable of ensuring the higher quality of yokukansan, and provides a bioassay method for yokukansan, comprising adding glutamate in an amount sufficient to induce cell death and yokukansan to a medium for culturing cells, and evaluating pharmacological... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110027817 - Tau protein screening assay: This invention is directed to methods for determining if a test compound can ameliorate tau protein induced reduction of long term potentiation in a neural structure. The invention is also directed to methods for determining if a test compound can re-establish or rescue synaptic function in a neural structure following... Agent: Wilmerhale/columbia University
20110027819 - Use of sfrp-3 in the assessment of heart failure: Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker SFRP-3, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration... Agent: Roche Diagnostics Operations Inc.
20110027822 - Systemic lupus erythematosus: This document relates to methods and materials involved in diagnosing SLE. For example, this document relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, this document provides nucleic acid arrays that can be used to diagnose... Agent: Fish & Richardson P.C. (tc)
20110027823 - Method and reagents for detecting the presence or absence of staphylococcus aureus in a test sample: A presence/absence test for Staphylococcus aureus (S. aureus) involves placing a first generation test sample in a solution that will clot in the presence of S. aureus. The solution contains components that will selectively grow S. aureus and also contains clotting factors that will react with S. aureus, if S.... Agent: O''shea Getz P.C.
20110027825 - High resolution classification: The present invention relates to a method of determining pulse height distribution by using an apparatus comprising: an analogue to digital pulses height categorisation unit comparing the pulse to analogue threshold voltages and counting each event within each pulse height category using a micro controller. The method may comprise the... Agent: Volentine & Whitt PLLC
20110027826 - Leukocyte analysis method and analysis reagent for use in the method: The present invention provides a method for analyzing leukocytes, by which the leukocytes can be classified and measured stably with high accuracy even when a dilution ratio of a sample containing the leukocytes is low or a flow velocity during the analysis is slow, and an analysis reagent used for... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20110027824 - Method and apparatus for analyzing body fluids: A system and method for analyzing a specimen containing particles that can be difficult to differentiate. The system and method determines a first collective count of a selected group of particles in the specimen, treats at least a portion of the specimen to alter a subgroup of the selected group... Agent: Dla Piper LLP (us )
20110027828 - Enzymatic modification in a continuously regenerated packed bed column: A process for the modification of a substrate comprising passing the substrate through a packed bed column of a specific volume of immobilized enzyme wherein the substrate enters the column at or near one end of the column (the ‘inlet end’) and the modified substrate exits at or near the... Agent: The Webb Law Firm, P.C.
20110027827 - Integrated system for production of biofuel feedstock: Disclosed is a culture system for the production of algae biomass to obtain lipid, protein and carbohydrate. By integrating heterotrophic processes with a phototrophic process in parallel, this system provides year around production in colder climates. By integrating heterotrophic processes with a phototrophic process in series, this system creates a... Agent: Whitham, Curtis & Christofferson & Cook, P.C.
20110027829 - Methods and compositions: The invention relates to a tRNA synthetase capable of binding N⊂-acetyl lysine, in particular, the invention relates to a tRNA synthetase capable of binding N∈-acetyl lysine wherein said synthetase comprises a polypeptide having at least 90% sequence identity to the amino acid sequence of MbPy1RS. The invention also relates to... Agent: Mcandrews Held & Malloy, Ltd
20110027830 - Use of an aspartic protease (ns24) signal sequence for heterologous protein expression: The invention relates to heterologous polypeptide expression and secretion by filamentous fungi and vectors and processes for expression and secretion of such polypeptides. More particularly, the invention discloses the use of a signal sequence form an aspartic protease obtained from Trichoderma and referred to as an NSP24 signal sequence.... Agent: Danisco US Inc. Attention: Legal Department
20110027831 - Production of sialylated n-glycans in lower eukaryotes: The present invention relates to eukaryotic host cells which have been modified to produce sialylated glycoproteins by the heterologous expression of a set of glycosyltransferases, including sialyltransferase and/or trans-sialidase, to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. Novel eukaryotic host cells expressing a CMP-sialic acid biosynthetic... Agent: Merck
20110027833 - Thermostable type-a dna polymerase mutants with increased polymerization rate and resistance to inhibitors: The present invention provides mutants of DNA polymerases having an increased rate of incorporation of nucleotides into nucleic acids undergoing polymerization and having an enhanced resistance to inhibitors of DNA polymerase activity. The mutant polymerases are well suited for fast PCR applications, for PCR amplification of targets in samples that... Agent: Agilent Techologies Inc, In Care Of: Cpa Global
20110027832 - Use of taq polymerase mutant enzymes for nucleic acid amplification in the presence of pcr inhibitors: The present invention generally relates to detection of a target nucleic acid in standard PCR, real-time PCR, RT PCR, and real-time RT PCR. One aspect of the invention provides mutant DNA polymerase enzymes that are resistant to PCR inhibitors, such as dye, blood, and soil. Another aspect of the invention... Agent: Snr Denton US LLP
20110027834 - Carry-over protection in enzyme-based dna amplification systems targeting methylation analysis: The invention refers to a method for providing a decontaminated template nucleic acid for enzymatic amplification reactions suitable for DNA methylation analysis. This method is characterized by the following steps: a) incubating a nucleic acid with a chemical reagent or an enzyme-containing solution, whereby the unmethylated cytosine bases are converted... Agent: Epigenomics Ag
20110027835 - Methods of modifying nucleic acids in host cells: A method of double crossover homologous recombination in a host cell comprising: a first homologous recombination event between a donor DNA molecule comprising a first element of a selectable allele and an acceptor DNA molecule comprising a second element of the selectable allele in the host cell, thereby to form... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20110027836 - Glucoamylase variants: The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.... Agent: Novozymes North America, Inc.
20110027837 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent: Xyleco, Inc. Celia Leber
20110027838 - Sphingomonas strains producing greatly increased yield of phb-deficient sphingan (diutan): PHB-deficient Sphingomonas strains having improved sphingan yield are provided. Certain of the Sphingomonas strains are diutan-producing strains that exhibit a dramatic improvement in productivity and yield due to a combination of certain genetic modifications that affect PHB and sphingan synthesis. Moreover, the sphingans produced from such strains have superior characteristics... Agent: Cp Kelco Us, Inc C/o Pete Pappas, Sutherland, Asbill & Brennan LLP
20110027839 - Mixture of culture products of filamentous fungi or dried product thereof, which exhibits cellulolytic activity, and method for producing glucose using the same: An objective of the present invention is to provide a method for enzymatically saccharifying a cellulosic substance in an extremely efficient, simple, and inexpensive manner. A solution to the object is a mixture or a dried product thereof exhibiting cellulolytic activity containing a culture liquid or a supernatant liquid of... Agent: Sughrue Mion, PLLC
20110027840 - Microorganism producing glutamic acid in high yield and a process of producing glutamic acid using the same: Disclosed herein are mutant strains, KCCM-10784P and KCCM-10785P, which are obtained through gene manipulation of Corynebacterium glutamicum KFCC-11074, and a process of producing L-glutamic acid using the mutant strains. The mutant strains are capable of producing L-Glutamic acid at high yield.... Agent: Edwards Angell Palmer & Dodge LLP
20110027841 - Method for preparation of oxylipins: The invention provides methods of producing oxygenated derivatives of polyunsaturated fatty acids (PUFAs).... Agent: Sheridan Ross PC
20110027842 - Method for producing monosaturated glycerides: A process for producing a glyceride product which is enriched in monounsaturated fatty acids relative to the starting glyceride comprising the steps: (a) alcoholysis of triglycerides employing lipolytic enzymes selective for saturated fatty acids and/or lipolytic enzymes selective for the 1-position, the 3-position or both positions in a glyceride; and... Agent: Novozymes North America, Inc.
20110027843 - Method for producing polyhydroxyalkanoate: A method for producing polyhydroxyalkanoate (PHA), comprising (i) culturing in a culture medium comprising terephthalic acid and/or a salt thereof and/or an ester thereof one or more bacterial strains which are capable of accumulating PHA from terephthalic acid or a salt or ester thereof and which are selected from Pseudomonas... Agent: Smith Moore Leatherwood LLP
20110027844 - Method for producing quinones: A method for conveniently and efficiently producing quinones, and particularly menaquinone, from a microorganism is provided. The present invention relates to a method for producing quinones, comprising culturing a microorganism that produces quinones in the presence of a porous carrier.... Agent: Sughrue Mion, PLLC
20110027845 - Enhanced ethanol and butanol producing microorganisms and method for preparing ethanol and butanol using the same: The present invention relates to a recombinant microorganism having an enhanced ability to produce ethanol and butanol and a method for preparing ethanol and butanol using the same, and more particularly to a recombinant microorganism having an enhanced ability to produce ethanol and butanol, into which a gene encoding CoA... Agent: Moore & Van Allen PLLC
20110027846 - Control of bacteria in fermentation processes: A method of producing a fermentation-based product comprises fermenting a sugar-containing medium with yeast in the presence of an organic biocide and a quaternary ammonium compound, in amounts sufficient to reduce or control a bacterial population in the sugar-containing medium. The additives enable reduction or elimination of antibiotics while still... Agent: The Dow Chemical Company
20110027847 - Hexose-pentose cofermenting yeast having excellent xylose fermentability and method for highly efficiently producing ethanol using the same: Genetic recombinant yeast expressing xylose reductase (XR), (wild-type or mutant) xylitol dehydrogenase (XDH), and xylulokinase (XK) and a method for highly efficiently producing ethanol from xylose using the yeast are provided. Pichia stipitis-derived XR and (wild-type or modified-type) XDH genes and Saccharomyces cerevisiae-derived XK gene were introduced via chromosomal integration.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110027849 - Formation pretreatment with biogenic methane production enhancement systems: Systems for enhanced in-situ or perhaps even ex-situ biogenic methane production from hydrocarbon-bearing formations (1) including coal seam, oil shale, coal, coal derivates and the like are presented in embodiments such as but not limited to: increasing and perhaps even selection of microbial populations (2), amending CBM water and other... Agent: Santangelo Law Offices, P.C.
20110027848 - Method of producing coupled radical products from biomass: A method that produces coupled radical products from biomass. The method involves obtaining a lipid or carboxylic acid material from the biomass. This material may be a carboxylic acid, an ester of a carboxylic acid, a triglyceride of a carboxylic acid, or a metal salt of a carboxylic acid, or... Agent: Ceramatec, Inc.
20110027850 - In situ precipitation of calcium carbonate (caco3) by indigenous microorganisms to improve mechanical properties of a geomaterial: A method for increasing the concentration of calcium carbonate in a geomaterial that contains indigenous microorganisms capable of hydrolyzing urea to ammonia, which method includes enriching the geomaterial with a source of nutrients, adding urea to the geomaterial which is hydrolyzed to ammonia and which raises the pH of the... Agent: Howard Eisenberg, Esq.
20110027851 - Compositions, methods and uses for biosynthetic plasmid integrated capture elements: Embodiments herein report compositions, systems and methods for making and using plasmid vectors and nanotube complexes. In certain embodiments, compositions, systems and methods herein include making plasmid vectors having aptamer inserts. In some embodiments, methods disclosed herein may be used to rapidly generate large quantities of plasmid vectors having aptamer... Agent: Faegre & Benson LLP Patent Docketing - Intellectual Property
20110027852 - Processing lignocellulosic biomass to fixed, high levels of dry matter content.: The invention relates in general to methods of processing lignocellulosic biomass and to methods of pre-treatment of lignocellulosic pretreated with steam biomass. In particular, the invention provides methods which fix moisture levels in lignocellulosic biomass to levels near the inherent water holding capacity of the material.... Agent: Plougmann & Vingtoft A/s
20110027853 - Phantom for the experimental in-vitro validation of radiation procedures under the influence of motion, taking into account the biological effective dose: A phantom device for in-vitro validation of radiation procedures under motion influence in consideration of an effective biological dose includes a phantom having a first biological detector with a first biological sample. The first biological sample includes a plurality of culturing and irradiation elements. Each of the culturing and irradiation... Agent: Leydig, Voit And Mayer
20110027854 - Method for concentrating viruses, method for concentrating cells or bacteria, and magnetic composite: A method for concentrating viruses includes applying a magnetic force to a mixture containing: sugar chain-immobilized magnetic metal nano-particles each having a structure in which a sugar chain-immobilized metal nano-particle is bound to a first magnetic nano-particle; second magnetic particles with mean particle size larger than that of the sugar... Agent: Morrison & Foerster LLP
20110027855 - Maize cellulose synthases and uses thereof: The invention provides isolated cellulose synthase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering cellulose synthase levels in plants. The invention further provides recombinant expression cassettes, host cells, and transgenic plants comprising said nucleic acids.... Agent: Pioneer Hi-bred International, Inc.
20110027856 - Compositions and methods for inhibition of the jak pathway: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.... Agent: Weaver Austin Villeneuve & Sampson LLP
20110027857 - Methods of improving the introduction of dna into bacterial cells: The present invention relates to methods of improving the introduction of DNA into bacterial host cells.... Agent: Novozymes, Inc.
20110027858 - Method of modifying fungal morphology: Provided is a method of modifying fungal morphology. The method comprises introducing an amount of a surfactant to a fungus, or to a growing mixture comprising a fungus, wherein said amount of a surfactant is sufficient to induce a change in the morphology of said fungus.... Agent: Brouse Mcdowell Lpa
20110027859 - Method for producing aminopeptidase: Disclosed is an efficient method for production of aminopeptidase. The method comprises either transforming host bacteria with an aminopeptidase gene and with a neutral protease gene, or transforming some part of host bacteria with an aminopeptidase gene while transforming the other part of the host bacteria with a neutral protease... Agent: Millen, White, Zelano & Branigan, P.C.
20110027860 - Gene encoding chondroitinase abc and uses therefor: Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABC protein produced in a host cell transformed with a nucleic acid vector directing the expression of a nucleotide sequence coding for chondroitinase ABC protein are described. Chondroitinase ABC prepared by chemical synthesis is also described. Monoclonal and... Agent: Nelson Mullins Riley & Scarborough LLP Floor 30, Suite 3000
20110027861 - Desiccated biologics and methods of preparing the same: The present invention provides compositions comprising desiccated biologics comprising a cell, protein, virus, nucleic acid, carbohydrate, or lipid, or any combination thereof, along with at least one membrane penetrable sugar, and at least one membrane impenetrable sugar, wherein the moisture content is from 5% to 95%, and to methods of... Agent: Pepper Hamilton LLP
20110027863 - Laboratory vessel with shiftable vessel closure: The present invention pertains to vessels with a vessel closure, and in particular to laboratory vessels with a shiftable closure assembly. The laboratory vessel comprises a container comprising an outwardly extending neck with an opening which provides access to the interior of said container, at least one guiding device comprising... Agent: Knobbe Martens Olson & Bear LLP
20110027862 - Sample stabilization: This disclosure relates to reagents, compositions, methods for stabilising RNA in an RNA-containing sample by contacting the sample with guanidine and a metal ion to form a stabilised RNA-containing composition in which the metal ion is present at a concentration which is no more than 20 mM, and the metal... Agent: Life Technologies Corporation C/o Intellevate
20110027864 - Process for preparing 2-hydroxy-4-substituted pyridines: A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided.... Agent: Heslin Rothenberg Farley & Mesiti PC
20110027865 - Everninomicin biosynthetic genes: This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin... Agent: Merck Patent Department (k-6-1, 1990)
20110027866 - Carrier piece and method for preparing culture media: The method provides a simple, accurate and inexpensive way to prepare culture media for conducting microbiological analysis with an absolute minimum of facilities, extraneous equipment and time consuming procedures. The invention introduces the use of a carrier piece that is suitable for carrying a reactant material for combining with growth... Agent: Botkin & Hall, LLP
20110027867 - Methods and compositions for the production of orthogonal trna-aminoacyltrna synthetase pairs: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in viva... Agent: Quine Intellectual Property Law Group, P.C.
20110027868 - Apparatus and method for dehydrating biological materials: An apparatus for dehydrating a liquid sample of biological material has a microwave waveguide that is open to the atmosphere. It has a microwave generator, means for introducing a container of the material into the waveguide, means for evacuating the container, means for rotating the container and means for removing... Agent: Mckee, Voorhees & Sease, P.L.C
20110027869 - Compositions for chemical and biological defense: One aspect of the present invention relates to reactive compositions and methods of use thereof, wherein a metal oxide cluster is used to connect a reactive group (or groups) to the surface of a substrate. In certain embodiments, the reactive group in the compositions decomposes organophosphate agents through nucleophilic hydrolysis.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20110027870 - Biomass carriers, method and apparatus for manufacture thereof and fluid treatment systems and methods utilizing same: A biomass carrier including a multiplicity of generally elongate plastic biomass attachment strips joined to each other at least one location therealong, the multiplicity of generally elongate plastic biomass attachment strips being mutually arranged to define a generally deformable biomass carrier including generally outer disposed biomass attachment strips and generally... Agent: Sughrue Mion, PLLC
20110027871 - Apparatus for demineralizing osteoinductive bone: The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process.... Agent: Morgan Lewis & Bockius LLP
20110027872 - Cantilever for measuring intra-cellular and inter-cellular microspaces: A cantilever for measuring intra-cellular and inter-cellular microspaces of the present invention includes a support portion, a lever portion provided to the support portion so as to protrude therefrom, and a probe portion provided near a free end of the lever portion. The probe portion includes a conductive probe made... Agent: Scully Scott Murphy & Presser, PC
20110027873 - Micro-nano fluidic biochip for assaying biological sample: Disclosed is a micro-nano fluidic biochip for assaying a biological sample comprising a first substrate, a second substrate and a third substrate which are sequentially stacked from bottom to top, wherein an upper channel assembly disposed on the second substrate is coupled with the lower channel assembly provided on the... Agent: Sughrue Mion, PLLC
20110027874 - Packed bed for nucleic acid capture and amplification: A system for nucleic acid capture and amplification comprising introducing a sample potentially containing the nucleic acid into a packed bed wherein the nucleic acid adheres to the packed bed, introducing an amplification mix into the packed bed, and thermal cycling the packed bed and the nucleic acid between denaturation... Agent: Lawrence Livermore National Security, LLC
20110027875 - Inexpensive, vertical, production photobioteactor: A production photobioreactor for culturing microalgae has a primarily vertical orientation of parallel transparent columns or tubes connected in a closed loop serpentine fashion. Generally no pump is required. The flow is maintained by gas diffusion in alternate columns (up columns) having a rate and volume as to provide an... Agent: George Philip White Patent Agent
20110027876 - Cryopreparation chamber for manipulating a sample for electron microscopy: The present invention relates to a cryopreparation chamber (100) for preparing and manipulating a sample for electron microscopy, the cryopreparation chamber (100) being cooled by a primary cryogen, the cryopreparation chamber (100) including a first and a second chamber portion (101,102), the second chamber portion (102) being detachably placeable (101)... Agent: Hodgson Russ LLP The Guaranty Building
20110027877 - Recipient device and method to protect in vitro cultured embryos and cells against atomospheric shock: A recipient device comprises a base (10) with a transparent bottom wall (11) and at least a sidewall portion (12) which defines, superiorly, a seat (5) for a removable and transparent lid (20), to be attached to the base (10), to be selectively switchable between a non-operant position, allowing fluid... Agent: Darby & Darby P.C.
20110027878 - Random homozygous gene perturbation to enhance antibody production: The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates,... Agent: Steven B. Kelber Berenato & White, LLC
20110027879 - Adipose-derived stem cells and lattices: The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells.... Agent: Mandel & Adriano
20110027880 - Cell culture system for pancreatic islands: Three-dimensional (3D) insulin-producing cell clusters derived from stem cells (preferably human embryonic stem cells) are provided by this invention, together with a method for their production using a microgravity bioreactor cell culture system.... Agent: Volpe And Koenig, P.C.
20110027881 - Production method of immune cells: A production method of T cells is disclosed which includes generating iPS cells from immune cells and differentiating the iPS cells into desired immune cells. In this method, 4 different genes Oct4, Sox2, Klf4 and c-Myc are introduced into immune cells for generation of iPS cells, and the iPS cells... Agent: The Nath Law Group
20110027884 - Combination of insulin and ascorbate to enhance wound healing: Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis... Agent: Smith Hopen, Pa
20110027882 - Methods and compositions for treating neurological disease: This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases.... Agent: Lando & Anastasi, LLP A2038
20110027883 - Rna interference mediating small rna molecules: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20110027885 - System and method for micromanipulating samples: A system and method for micromanipulating samples are described to perform automatic, reliable, and high-throughput sample microinjection of foreign genetic materials, proteins, and other molecules, as well as drawing genetic materials, proteins, and other molecules from the sample. The system and method overcome the problems inherent in traditional manual micromanipulation... Agent: Eduardo Krupnik
20110027886 - Method of inducing differentiation of embryonic stem cells into hemangioblast: The present invention relates to a composition for inducing embryonic stem cell differentiation comprising a MEK/ERK (mitogen-activated protein kinase kinase/extracellular regulated kinase) signal transduction inhibitor and BMP (bone morphogenetic protein), and a method for inducing differentiation of embryonic stem cells into mesodermal cells using the same. Further, the mesodermal cells... Agent: Knobbe Martens Olson & Bear LLP
20110027887 - Method of dynamically culturing embryonic stem cells: The present invention is of a method of dynamically generating human embryoid bodies which can be used for generating lineage specific cells and cell lines. Specifically, the present invention can be used to generate ESC-differentiated cells for cell-replacement therapy.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20110027888 - Coated fibers for culturing cells: A coated fiber for cell culture includes a fiber core having an exterior surface and a polymeric coating suitable for culturing cells disposed on at least a portion of the exterior surface of the fiber core. A polypeptide may be conjugated to the polymeric coating. A method for forming the... Agent: Corning Incorporated
20110027889 - Synthetic microcarriers for culturing cells: A coated microcarrier for cell culture includes a microcarrier base and a polymeric coating grafted to the base via a polymerization initiator. A method for forming the coated microcarrier includes (i) conjugating a polymerization initiator to the microcarrier base to form an initiator-conjugated microcarrier base; (ii) contacting the initiator-conjugated microcarrier... Agent: Corning Incorporated
20110027891 - Mammalian cell culture media which comprise supernatant from cohn fractionation stages and use thereof: The present invention relates to mammalian cell culture media which comprise supernatant from some of the fractions of human plasma fractionation according to the Cohn method, more specifically, the supernatant of fractions I and II+III. When said supernatant is added as a culture medium supplement it provides various nutrients and... Agent: Buchanan, Ingersoll & Rooney PC
20110027890 - Material for cell culture: A ligand construct containing at least two, identical or different, ligand molecules which are capable of binding to a cell surface receptor, the ligand molecules being coupled via a spacer, wherein the ligand construct has at least one functional group for binding substrates. According to the ligand construct of the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.Previous industry: Education and demonstration
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