|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology January recently filed with US Patent Office 01/11Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 01/27/2011 > 155 patent applications in 68 patent subcategories. recently filed with US Patent Office
20110020784 - Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation: Polynucleotides encoding variant polypeptides of DsRed are provided herein. The DsRed variants have increased bacterial expression, reduced aggregation, increased solubility, shifted emission spectra or increased brightness relative to a wild-type DsRed.... Agent: Michael Best & Friedrich LLP
20110020785 - Diagnostic information generation and use: This invention relates generally to a process for producing machine readable contextual diagnostic information and use of contextual diagnostic information for generating tangible and useful results. The process provides the highest level of integration of diagnostic information collected in a distributed or centralized system comprising diagnostic devices and a global... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20110020791 - Methods and materials for detecting mutations in quasispecies having length polymorphisms: The present invention is directed to a method for detecting the presence or absence of a mutation of interest in the nucleic acid of a pathogen, wherein the mutation of interest is located adjacent to a length polymorphism defining multiple quasispecies of the pathogen.... Agent: Siemens Corporation Intellectual Property Department
20110020789 - Methods for assessing fatigue level and applications thereof: Level of fatigue that accompanies everyday life or a disease can be simply, easily, and quantitatively assessed by obtaining a body fluid from a test subject and measuring the amount of human herpesvirus in the body fluid. Furthermore, the anti-fatigue potency of anti-fatigue substances and anti-fatigue food products can be... Agent: Hunton & Williams LLP Intellectual Property Department
20110020787 - Nmr device for detection of analytes: This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR... Agent: Clark & Elbing LLP
20110020788 - Nmr device for detection of analytes: This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR... Agent: Clark & Elbing LLP
20110020786 - Peptide dendrimers: affinity reagents for binding noroviruses: Noroviruses are recognized as the most common cause of outbreaks of acute gastroenteritis in humans. Therefore, the present invention relates to peptides or dendrimers that bind Noroviruses and the methods for identifying and synthesizing these peptides. It also relates to the detection of Noroviruses using said peptides or dendrimers formed... Agent: Fulbright & Jaworski, LLP
20110020790 - Use of regulatory sequences for specific, transient expression in neuronal determined cells: The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the... Agent: Fulbright & Jaworski L.L.P.
20110020813 - Advanced pathogen detection and screening: Disclosed is a rapid, dual purpose, PCR-based method for identifying two or more pathogens, including Giardia and/or Cryptosporidium, in an extracted sample, such as stool or environmental (soil, water) isolates, in individual real-time PCR reactions. This method is of particular utility for clinical, veterinary, and environmental testing applications. The present... Agent: Mcguirewoods, LLP
20110020795 - Analyzing the fmr1 gene: A method of predicting a degree of risk of early ovarian aging of a young female. The method includes analyzing the female's FMR1 gene, wherein the FMR1 gene has a first allele and a second allele; determining the number of triple CGG repeats on each of the first and second... Agent: Beem Patent Law Firm
20110020808 - Biomarkers for diagnosing schizophrenia and bipolar disorder: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of... Agent: Edwards Angell Palmer & Dodge LLP
20110020801 - Carboxylesterase-1 polymorphisms and methods of use therefor: Methods and kits are provided for detecting polymorphisms in carboxylesterase-1 (CES1). Several single nucleotide polymorphisms (SNPs) in CES1 in humans, and methods for detecting the same, are provided (e.g., Gly143Glu, 12754T>del). Results indicate that the Gly143Glu (9486G>A) polymorphism has an allelic frequency of 1.5% in the Caucasian population. Polymorphisms of... Agent: Fulbright & Jaworski L.L.P.
20110020828 - Ce43-67b insecticidal cotton: The present application relates an insect resistant transgenic cotton plant. In particular, it relates to a specific event, designated CE43-67B. The application also relates to polynucleotides which are characteristic of the CE43-67B event, plants comprising said polynucleotides, and methods of detecting the CE43-67B event.... Agent: Syngenta Biotechnology, Inc. Patent Department
20110020800 - Characterization of bbk07 antigen of borrelia burgdorferi and methods of use: In this application is described the characterization Borrelia burgdorferi lipoprotein BBK07, an in vivo expressed and surface-exposed immunogen. BBK07 expression in the infected hose can be detected at the RNA and protein level as early as the first week of infection. Therefore, described is the use of BBK07 antigen and... Agent: Pratt & Associates, Inc.
20110020796 - Compositions, methods, and kits for the detection of chlamydia trachomatis: Method for the detection of Chlamydia trachomatis, which method comprises the performance of a DNA amplification involving the use of a primer pair by using DNA that is derived from a sample as a template and the detection of an amplification product, characterized in that the primer pair used for... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20110020817 - De novo synthesized plasmid, methods of making and use thereof: The invention relates to a de novo synthesized plasmid. The plasmid comprises relevant sequences for plasmid replication and plasmid selection. The methods of making and use of the plasmid are disclosed. The plasmid can be used to make other plasmids. These plasmids and their host cells can be used for... Agent: Chuan Li
20110020830 - Design for rapidly cloning one or more polypeptide chains into an expression system: The present invention provides methods and compositions for the generation and identification of expression constructs that can be used to express sufficient levels of a polypeptide of interest. The compositions include a population of expression vectors, wherein members of the population have a type IIS restriction enzyme recognition site adjacent... Agent: Wilson, Sonsini, Goodrich & Rosati
20110020792 - Detection of uterine leiomyosarcoma using lmp2: This invention provides a method for detecting the presence of uterine leiomyosarcoma using the transcription or expression level of LMP2 and/or cyclin E in uterine smooth muscle tissue as an indicator and a method for detecting uterine leiomyosarcoma using LMP2 and/or cyclin E as a marker.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110020831 - Genetic detection of hiv-1 strains that use the cxcr4 co-receptor: i
20110020811 - Host cells comprising alpha 1,2 mannosidase and culture methods thereof: Improved host cells and culture methods involving overexpression of MAN1C1 activity to improve protein production are provided.... Agent: Amgen Inc.
20110020819 - Isothermal detection methods and uses thereof: The present disclosure relates to methods and probes for rapid, single temperature (isothermal) detection of specific nucleic acid sequences. The methods and probes provide a simple method for detecting bioagents including bacteria and viruses, and the detection of specific genetic markers on any nucleic sequence.... Agent: Morrison & Foerster LLP
20110020803 - Markers for the prognosis of lung function and colonization with an infectious agent: The present invention provides a method and kit for determining the risk for impaired lung function and/or the susceptibility for colonization with an infectious agent. The method and kit comprise determining the presence or absence of one or more nucleic acid variants in a gene or a combination of genes.... Agent: Nixon & Vanderhye, PC
20110020832 - Method for detecting cancer cell caused by hpv, method for determining whether or not tissue is at stage of high-grade dysplasia or more severe stage, and primer set and kit used therefor: Provided are a primer set, a method and a kit therefor, which can easily perform with high accuracy the detection of a cancer cell caused by HPV and the determination of whether or not a tissue is a tissue with high-grade dysplasia or in a more severe phase. As a... Agent: Sughrue Mion, PLLC
20110020794 - Method for the detection of diagnostic rna: Methods for the direct detection of diagnostic target RNA have been developed, which obviate the need for time consuming RNA purification and isolation procedures.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110020824 - Methods and compositions for quantitative amplification and detection over a wide dynamic range: Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations... Agent: Gen Probe Incorporated
20110020814 - Methods and compositions for selection of stem cells: Described herein are methods and compositions for selection of pluripotent stem cells from a population of mammalian cells (e.g., human) undergoing a process that induces some cells within the population to become pluripotent.... Agent: Wilson, Sonsini, Goodrich & Rosati
20110020826 - Methods for assessing efficacy of chemotherapeutic agents: Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the ability of a chemotherapeutic to destroy cells and the genetic propensity of those cells for resistance. Results obtained using methods of the invention provide... Agent: Cooley LLP Attn: Patent Group
20110020815 - Methods for genomic analysis: The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.
20110020797 - Methods for identifying patients with an increased likelihood of responding to dpp-iv inhibitors: The invention provides novel in vitro diagnostic methods for identifying patients who may have an increased likelihood of responding to DPP-IV inhibitor therapy. The invention also provides novel polynucleotides associated with increased responsiveness of a patient to DPP-IV inhibition. Polynucleotide fragments corresponding to the genomic and/or coding regions of these... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP Bristol-myers Squibb
20110020812 - Methods of using fet labeled oligonucleotides that include a 3'-5' exonuclease resistant quencher domain and compositions for practicing the same: Methods and compositions are provided for detecting a primer extension product in a reaction mixture. In the subject methods, a primer extension reaction is conducted in the presence of a polymerase having 3′→5′ exonuclease activity and at least one FET labeled oligonucleotide probe that includes a 3′→5′ exonuclease resistant quencher... Agent: Life Technologies Corporation C/o Intellevate
20110020807 - Methylated cpg island amplification (mca): The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethylated PcG sites and contacting the sample with an isoschizomer of the methylation sensitive restriction endonuclease, which cleaves both methylated and unmethylated CpG... Agent: Dla Piper LLP (us)
20110020809 - Mild osteoarthritis biomarkers and uses thereof: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of... Agent: Edwards Angell Palmer & Dodge LLP
20110020827 - Modified nucleosides and nucleotides and uses thereof: The invention is directed to modified guanine-containing nucleosides and nucleotides and uses thereof. More specifically, the invention relates to modified fluorescently labelled guanine-containing nucleosides and nucleotides which exhibit enhanced fluorophore intensity by virtue of reduced quenching effects.... Agent: Mcdermott, Will & Emery LLP
20110020793 - Molecular counting by color-coded micelles: The invention provides a method of determining ratios of target DNA molecules in a sample. A digital readout of the target DNA molecules is provided by converting ratios of target DNA molecules into equivalent ratios of amplifiable tags, which are, in turn, converted into ratios of color-coded micelles in an... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20110020822 - Molecular detection of chromosome aberrations: The invention relates to the field of cytogenetics and the application of genetic diagnostic techniques in pathology and hematology. Specifically, the invention relates to nucleic acid probes that can be used in hybridization techniques for the detection of chromosomal aberrations and other gene rearrangements such as immunoglobulin and T-cell receptor... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20110020805 - Mutational analysis of chronic myeloproliferative disorders: The invention relates to molecular assays, reagents and kit for the mutational analysis, for diagnostic and prognostic purposes, of chronic myeloproliferative disorders, a group of neoplastic pathologies of the haemopoietic system. The invention relates to the identification of nucleic acid probes labelled with fluorochrome, allowing a quantitative assessment, in a... Agent: Steinfl & Bruno
20110020798 - Novel italy, lor-2, strife, trash, bdsf, lrsg, and stmst protein and nucleic acid molecules and uses therefor: Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST proteins, the invention further provides isolated ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST fusion proteins, antigenic peptides and anti-ITALY,... Agent: Millennium Pharmaceuticals, Inc.
20110020802 - Nucleic acids, methods and kits for the diagnosis of dyt6 primary torsion dystonia: The invention relates generally to the THAP1 gene and mutations in this gene, as well as the THAP1 protein and mutations in this protein, that are associated with dystonia. The invention relates to the identification, isolation, cloning and characterization of the DNA sequence corresponding to the wild type and mutant... Agent: Fish & Richardson P.C. (ny)
20110020804 - Photoinduced electron transfer (pet) primer for nucleic acid amplification: This application provides photoinduced electron transfer (PET) nucleic acid molecules that can be used detect and amplify nucleic acid molecules, such as target nucleic acid molecules. These PET tags can be attached to the 5′-end of a target sequence-specific primer, thereby generating a PET primer. In particular examples, a PET... Agent: Klarquist Sparkman, LLP
20110020816 - Precursor mirna loop-modulated target regulation: By modifying nucleotides from either or both the stem and loop of precursor-miRNA, greater specificity is achieved as to the mRNAs targeted. The improved efficiency in target regulation can be either mediated by direct base-pairings between targets and precursor miRNAs or indirectly by energy constraints on the availability of such... Agent: Robins & Pasternak
20110020825 - Protein c polymorphisms useful as an indicator of patient outcome: The invention provides methods and kits for obtaining a prognosis for a patient having or at risk of developing an inflammatory condition. The method generally comprises determining a protein C promoter genotype of a patient for a polymorphism in the protein C promoter region of the patient, comparing the determined... Agent: Browdy And Neimark, PLLC
20110020829 - Rapid assay for detecting ataxia-telangiectasia homozygotes and heterozygotes: The present disclosure relates to methods for performing an assay to identify ataxia-telangiectasia homozygotes or heterozygotes. Some embodiments include the use of a rapid flow cytometry-based ataxiatelangiectasia (ATM) kinase assay that measures ATM-dependent phosphorylation of SMC1 following DNA damage.... Agent: Knobbe Martens Olson & Bear LLP
20110020806 - Rapid dna sequencing by peroxidative reaction: Disclosed is a method of polynucleic acid (e.g., DNA) sequencing which is based on the generation of pyrophosphate (PPi) that occurs when a complementary base is incorporated into a growing DNA strand being synthesized on a template. The method utilizes a cascade of enzymatic reactions catalyzed by hypoxanthine-phosphoribosyl transferase, xanthine... Agent: Peters Verny , L.L.P.
20110020818 - Reactor for the quantitative analysis of necleic acids: A reactor for the quantitative analysis of target nucleic acids using an evanescent wave detection technique and a method of use thereof is provided. The reactor includes a substrate with a cavity, a buffer layer arranged over the substrate; a cover plate arranged over the buffer layer, and inlet and... Agent: Honeywell/slw Patent Services
20110020799 - Screening method for damaged dna repairing substance: Provided are a novel screening method for a substance that potentiates damaged DNA repair capability, based on a test with DNA repair as an index with improved sensitivity as a simplified version of the currently available unscheduled DNA synthesis (UDS) assay based on 3H-thymidine and BrdU or recovery of RNA... Agent: Wenderoth, Lind & Ponack, L.L.P.
20110020823 - Sequences and their use for detection and characterization of e. coli o157:h7: This invention relates to a rapid method for detection and characterization of Escherichia coli bacteria serotype O157:H7 based on the presence of nucleic acid sequences, in particular, to a PCR-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. This method is preferably employed to detect... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.
20110020810 - Trpc6 involved in glomerulonephritis: Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion channel protein Transient Receptor Potential Cation Channel... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20110020835 - Device and method for detecting small quantities of light, comprising an electronic image converter embodied in semiconductor technology: The invention relates to a device for detecting small quantities of light, comprising an electronic image converter embodied in semiconductor technology for detecting the photons representing the small quantities of light and an electronic circuit connected to the electronic image converter for reading the electronic image converter and for generating... Agent: The Webb Law Firm, P.C.
20110020834 - High sensitivity mechanical resonant sensor: A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an immobilized binding partner that couples to a predetermined cell or molecule. A first resonant frequency is determined for... Agent: Schwegman, Lundberg & Woessner, P.A.
20110020833 - Method for detecting analytes: s
20110020837 - Method for isolating or identifying a target protein interacting with a lipid in a cell: The invention is in the field of molecular biology and cell biology. It provides tools and methods for studying the interaction of proteins and lipids in vivo as well as in vitro. The invention relates to a method for isolating or identifying a target protein interacting with a lipid in... Agent: Traskbritt, P.C.
20110020838 - Molecules for the treatment of lung disease involving an immune reaction to connective tissue found in the lung: Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one method pulmonary disease and disorders such as Idiopathic Pulmonary Fibrosis (IPF) are diagnosed by analyzing fluid or tissue samples obtained... Agent: Seed Intellectual Property Law Group PLLC
20110020836 - Process for differential polypeptides detection and uses thereof: Provided herein is an affinity media and the construction and use thereof. The affinity media may be used, for example, for the detection of differential proteins/peptides by depletion of proteins/peptides similar to those in a control sample from a test sample in the search for biologically and pathologically important proteins/peptides.... Agent: Nelson Mullins Riley & Scarborough LLP Floor 30, Suite 3000
20110020841 - Centrosome amplification as a biosensor for dna damage: The present invention provides an assay kit for identifying and/or monitoring genotoxic modulating agents comprising eukaryotic cells, characterised in that the cells stably express at least one labelled centrosome marker.... Agent: Foley & Lardner LLP
20110020842 - Eef2k assays for identifying compounds that inhibit eef2k activity: Assays for identifying novel compounds for inhibiting eEF2 kinase and consequence peptides employed therein.... Agent: Fox Rothschild LLP Princeton Pike Corporate Center
20110020843 - Label-free methods related to phosphodiesterases: 196. Disclosed are methods of incubating cells on biosensors, and methods using the disclosed incubation techniques to identify PDE4 modulators.... Agent: Corning Incorporated
20110020844 - Quantitative zap-70 assay: An quantitative ZAP-70 assay is provided, with ZAP-70+ and ZAP-70− controls, normal human blood controls, an improved antibody with better signal to noise ratio, and using the median MEFL that is calibrated using a standard curve.... Agent: Kilpatrick Stockton LLP
20110020845 - Method for the detection and identification of a variant c. difficile strain in a sample: The method for detecting and identifying a variant C. difficile strain in a sample is characterized by the following steps: (a) obtaining a sample of excreta or tissue from a human or animal patient body; (b) bringing the sample into contact with at least one antibody from each of at... Agent: Joyce Von Natzmer Pequignot + Myers LLC
20110020839 - Methods and compositions for detecting the activation state of multiple proteins in single cells: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP
20110020840 - Method and kits for detecting antibodies against therapeutic antibodies: The invention relates to the field of immunology and immunological diagnostics. More specifically, it relates to detection of the formation of antibodies in a subject that is treated with a therapeutic antibody. Provided is A diagnostic method for determining the presence of IgG antibodies against a therapeutic antibody in a... Agent: Hoffmann & Baron, LLP
20110020847 - Direct enzyme immunoassay and kit for measurement of serum progesterone levels: Compositions, methods and kits for determining progesterone levels in mares are disclosed.... Agent: Dann, Dorfman, Herrell & Skillman
20110020848 - Method for detection of pneumococcus: To provide an immunological detection method which can detect or quantify a pneumococcal antigen in a sample derived from a living body conveniently, rapidly, and with high sensitivity, and an antibody for use in the method. The present invention provides an antibody which specifically recognizes a pneumococcal F-antigen; a method... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110020846 - Oral cancer biomarker and inspection method using the same: The present invention discloses an oral cancer biomarker and an inspection method using the same. The biomarker is Mca-2 binding protein (Mac-2BP), which can be directly detected in the specimen of the body fluid of a testee, and which can realize a fast and effective clinical diagnosis of oral cancer.... Agent: Muncy, Geissler, Olds & Lowe, PLLC
20110020849 - Biomarkers for diagnostic and therapeutic methods: Erythrocyte ATP-release modulators and composition and methods for their use as biomarkers of glucose processing or vascular disorders, as well as methods for screening to identify to modulators; methods for monitoring efficacy of therapy; and apparatus for use in such methods.... Agent: Harness, Dickey & Pierce, P.L.C
20110020850 - Method of determining enzymatic activity in biological media: A reliable, fast and convenient method is provided to determine the change in concentration of enzyme in time in a biological medium in the presence of a signal substrate that corrects for substrate consumption, color-dependency of the signal and non-linearity between the concentration of the leaving group of the signal... Agent: Kalow & Springut LLP
20110020852 - Method of analyzing biological component, biological component analyzer and extraction cartridge: This method of analyzing a biological component includes steps of arranging an extraction medium holding part configured to be capable of holding a prescribed quantity of extraction medium for holding an extract extracted from a subject on the skin of the subject, transferring the extraction medium stored in a liquid... Agent: Brinks Hofer Gilson & Lione
20110020851 - Novel glucose dehydrogenase: The invention provides a glucose dehydrogenase that is an extremely stable enzyme having a thermostability of 80° C. or more, and that does not substantially act upon saccharides other than glucose (e.g., having a reactivity of less than 3% with respect to maltose, galactose, and xylose). The invention also provides... Agent: Leydig Voit & Mayer, Ltd
20110020853 - Compositions and methods for detecting phosphomonoester: The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound having an electrophilic moiety and a phosphomonoester moiety; (b) contacting the target compound with a first carbodiimide compound under conditions for preferential addition of... Agent: Illumina, Inc. Legal Department
20110020854 - Enhancing endotoxin detection: Provided herein are methods for detecting gram negative bacteria or lipopolysaccharide in a sample. Kits for detecting gram negative bacteria or lipopolysaccharide in a sample are provided.... Agent: Mckeon Meunier Carlin & Curfman LLC
20110020857 - Metabonomic methods to assess health of skin: The present invention relates to methods of assessing the health of skin. Biomarkers are used to evaluate skin samples. Using metabonomics approaches, samples taken from different skin sites or at different times during a treatment are used to diagnose skin conditions or to appraise various skin treatments for efficacy.... Agent: The Procter & Gamble Company Global Legal Department - Ip
20110020855 - Method and apparatus for performing cytometry: Embodiments of the present disclosure generally include a method and apparatus for performing cytometry. Specifically, embodiments of the invention comprise apparatus for providing a sample fluid to a cytometry system comprising a cytometry chip and a holder. The cytometry chip is for channeling a sample fluid from a sample fluid... Agent: Raymond R. Moser Jr., Esq. MoserIPLaw Group
20110020858 - Method of selecting and separating normal cells and specific cells by using ultrasonic waves: The present invention relates to a method of selecting and separating normal cells and specific cells by using ultrasonic waves. More particularly, the present invention relates to a method of selecting and separating normal cells and cancer cells, or normal cells and stem cells by using a difference in attenuation... Agent: Ampacc Law Group, PLLC
20110020856 - Perifusion device: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be... Agent: Gregory A. Nelson Novak Druce & Quigg LLP
20110020859 - Device comprising a coloured and biodegradable polymer layer for analyzing the age and/or quality of a natural product (integrated freshness indicator): The present invention relates to the field of analyzing the age and/or quality of certain natural products, for example foods. The invention also relates to devices for analyzing said age and/or quality as well as to methods for preparing such devices, to methods for analyzing natural products and to their... Agent: K&l Gates LLP
20110020860 - Fecal examination method and collection container: A method for conducting a fecal examination includes providing a collection spoon and a collection container comprising a transparent body having a cap which can be removed to permit fecal matter to be received in the collection container with the spoon to be mixed with a flotation material to aid... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c
20110020862 - Biological solids processing system and method: The consumption of organic solids with anaerobic digestion to generate usable gases including methane is made more efficient by maintaining the ideal digestion temperature, which is attained by combining the anaerobic digestion process with a halogen digester which produces heat energy and hydrogen gas. With a given biological feedstock four... Agent: Herbert Burkard
20110020863 - Bioreactor assembly and associated methods: A bioreactor assembly, including: a housing internally defining a plurality of reaction chambers; a medium flow supply line associated with each of the plurality of reaction chambers, wherein the medium flow supply line associated with each of the plurality of reaction chambers is operable for delivering a medium flow to... Agent: Clements Bernard PLLC
20110020864 - Preparation of high purity collagen: A method of preparing collagen by first producing a collagen matrix and then extracting collagen from the matrix.... Agent: Occhiuti Rohlicek & Tsao, LLP
20110020868 - Bacterial leader sequences for increased expression: Compositions and methods for improving expression and/or secretion of a polypeptide of interest in a host cell are provided. Compositions including a coding sequence for a bacterial secretion signal peptide are provided. The compositions of the invention are useful for increasing accumulation of properly processed proteins in the periplasmic space... Agent: Wilson, Sonsini, Goodrich & Rosati
20110020867 - Constructs and methods for efficient transformation of micro-organisms for production of carbon-based products of interest: Improved constructs for increasing efficiency of transformation of thermophilic host cells for production of carbon-based products of interest and methods for producing carbon-based products of interest are provided.... Agent: Joule/fenwick
20110020865 - Gene expression technique: The present invention provides a host cell suitable for enhanced production of a protein product of choice characterised in that the host cell is genetically modified to cause over-expression of two or more helper proteins selected from a DnaJ-like protein (such as JEM1), an Hsp70 family protein (such as LHS1)... Agent: Novozymes North America, Inc.
20110020869 - Methods for altering acetic acid production and enhancing cell death in bacteria: Methods of increasing cultured cell growth yields and/or protein production from bacterial cell cultures are provided. More particularly, mutant bacterial cells having an alteration in the expression or activity of the cidABC operon, a gene therein, or a homolog or a regulator thereof, and methods for reducing acetic acid/acetate production... Agent: Klarquist Sparkman, LLP
20110020866 - Promoter sequence for the expression of recombinant proteins in lactococcus lactis: The present invention relates to new DNA sequences that function as promoters, expression vectors containing such sequences, and host cells transformed with these vectors, in particular lactic acid bacteria such as Lactococcus lactis. The invention also relates to the use of these promoters for the production of heterologous proteins, in... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20110020870 - Methods for producing modified glycoproteins: Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower... Agent: Merck
20110020871 - Process for the preparation of insulin conjugates: The invention claims a process for making an insulin-oligomer conjugate IN-105. IN-105 precursor having formula G-A-V-R-[B-Chain]-R-D-A-D-D-R-[A-Chain] is cloned and expressed in Pichia. The biosynthetic precursor is then conjugated with an activated oligomer. The IN-105 precursor-oligomer conjugate is then treated with protease and purified to afford active insulin-oligomer conjugate of formula... Agent: Ballard Spahr LLP
20110020872 - Microorganism producing cyclic compound: A microorganism which produces compounds useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, such as mycotic sinusitis, is provided. The present inventors have conducted intensive studies on naturally-occurring microorganisms as a research for antifungal compounds, and found a fungus Acremonium persicinum which produces cyclic compounds having... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20110020873 - Biomass hydrolysis process: The invention relates to a biomass process comprising removal and/or inactivation of an enzyme inhibitor from recycled washing solution.... Agent: Novozymes North America, Inc.
20110020874 - Simplified method for digestion of cellulosic biomass: The inventive process converts cellulosic biomass into a gel-like state that is readily hydrolyzed by appropriate enzymes. First the biomass is mechanically reduced in size. The biomass is then mixed and kneaded with an aqueous solution of a hydrophilic polymer that acts as a conditioning agent or as a co-solvent.... Agent: Stefan Kirchanski
20110020875 - Hydrogenase polypeptide and methods of use: Provided herein are polypeptides having hydrogenase activity. The polypeptide may be multimeric, and may have hydrogenase activity of at least 0.05 micromoles H2 produced min−1 mg protein−1. Also provided herein are polynucleotides encoding the polypeptides, genetically modified microbes that include polynucleotides encoding one or more subunits of the multimeric polypeptide,... Agent: Mueting, Raasch & Gebhardt, P.A.
20110020877 - Cren7 chimeric protein: There is provided a chimeric protein comprising a nucleic acid modifying enzyme domain having nucleic acid modifying activity joined with an Cren7 enhancer domain or variant thereof, in which the Cren7 enhancer domain or variant thereof enhances the activity of the nucleic acid modifying enzyme domain compared with a corresponding... Agent: Hunton & Williams LLP Intellectual Property Department
20110020876 - Mesoscale polynucleotide amplification devices: Disclosed are devices for amplifying a preselected polynucleotide in a sample by conducting a polynucleotide amplification reaction. The devices are provided with a substrate microfabricated to include a polynucleotide amplification reaction, chamber, having at least one cross-sectional dimension of about 0.1 to 1000 μm. The device also includes at least... Agent: Dann, Dorfman, Herrell & Skillman
20110020878 - Method of removing nucleic acid contamination in reverse transcription and amplification reactions: The invention provides methods of removing nucleic acid contamination from reverse transcription reactions and hot-start PCR, wherein said hot-start PCR is a barrier hot-start PCR set up and/or involves a hot-start DNA polymerase, which methods comprise use of a DNase that is substantially irreversibly inactivated by heating at a temperature... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20110020879 - Reaction device, reaction method and method of synthesizing cdna: The present invention provides a device and a method whereby plural kinds of reaction operations and washing operations can be conducted in parallel without washing or replacing an instrument used in transferring a solution and the like in each operation. A reaction device having a plurality of projecting barriers provided... Agent: Ditthavong Mori & Steiner, P.C.
20110020880 - Compositions and methods for grain processing without ph adjustment: Described are compositions and methods relating to starch processing without a phytase pretreatment step and without adjustment of the slurry pH adjustment.... Agent: Danisco US Inc.
20110020881 - Method of producing biofuel using brown algae: In a method of producing biofuel using brown algae, Bacterium antarctica is used as a hydrolysis catalyst for saccharification to obtain monosaccharides from the brown algae. The saccharification with the hydrolysis catalyst is effective in saccharification of the brown algae.... Agent: Cantor Colburn LLP
20110020882 - Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using: The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides.... Agent: Cargill, Incorporated
20110020883 - Acyl-acp thioesterase genes and uses therefor: The present invention provides novel genes encoding Class II acyl-ACP thioesterases and variants thereof that are active on C8, C10, C12, C14, C16, and C18 acyl-ACP substrates. The thioesterases can be introduced into transgenic organisms, including microorganisms and photosynthetic organisms, for producing fatty acids and fatty acid products.... Agent: Synthetic Genomics, Inc. C/o Dla Piper LLP (us)
20110020884 - Method for the conversion of plant materials into fuels and chemicals by sequential action of two microorganisms: A process is disclosed for converting complex plant polysaccharides, including cellulosic materials, into fuels and other chemicals. In preferred embodiments, the process comprises sequential hydrolysis of the plant polysaccharides by two or more microorganisms... Agent: Wilson, Sonsini, Goodrich & Rosati
20110020886 - Method for producing polyhydroxyalkanoic acid: Provided is a method for producing a polyhydroxyalkanoic acid (PHA). More particularly, a method of preparing PHA containing a high content of long-chain aromatic monomer-units by growing a phaZ mutant of a Pseudomonas strain in a medium containing a sugar, a substituted fatty acid, and a salicylic acid.... Agent: Jae Y. Park
20110020885 - Use of glyphosate to produce shikimic acid in microorganisms: The present invention provides methods for producing shikimic acid. In particular the invention provides methods for producing and isolating shikimic acid from a microorganism. Additionally, the invention provides methods for synthesizing compounds such as oseltamivir and 6-fluoroshikimic acid using shikimic acid produced from microorganisms.... Agent: Senniger Powers LLP (mtc)
20110020888 - Method for preparing butanol through butyryl-coa as an intermediate using bacteria: The present invention relates to a method for producing butanol using a bacterium capable of biosynthesizing butanol from butyryl-CoA as an intermediate. More particularly, a method for producing butanol, the method comprising generating bytyryl-CoA in a bacterium which contains a gene coding for AdhE (an enzyme responsible for the conversion... Agent: Moore & Van Allen PLLC
20110020889 - Yeast organism producing isobutanol at a high yield: The present invention provides recombinant mircoorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described... Agent: Cooley LLP Attn: Patent Group
20110020890 - Increased ethanol production by bacterial cells: Fermentation processes for production of ethanol include supplying a thermophilic microorganism lacking lactate dehydrogenase activity with sugars under conditions in which they metabolise them predominantly by the pyruvate-formate lyase pathway. Importantly, the processes also include supplying sufficient glycerol to convert all of the sugars to ethanol. A further embodiment of... Agent: Mcandrews Held & Malloy, Ltd
20110020891 - Process for providing ethanol from plant material: The presently disclosed subject matter relates to processes that comprise the vacuum extrusion of plant materials. In some embodiments, the plant materials are subjected to a change in pressure of −3 kPa or more. The vacuum extrusion can be used to break open the cell walls of the plant material... Agent: Syngenta Biotechnology, Inc. Patent Department
20110020892 - Composition: There is provided an anti-fouling composition comprising (i) a surface coating material; (ii) an enzyme obtained or obtainable from a marine organism; and (iii) (a) a substrate for the enzyme; and/or (b) a precursor enzyme and a precursor substrate, wherein the precursor enzyme and the precursor substrate are selected such... Agent: Steptoe & Johnson LLP
20110020893 - Trapping discrete particles in fluids (for example, filtering for specific virus, molecule, or other identifiable particle in water, blood, air or other fluids): The invention describes a way to target and trap a specific particle (atom, molecule, bacterium, photon, ion, virus, etc.) that can be extracted from a moving fluid flow. Since every particle has a unique and identifiable shape and/or electromagnetic signature, a trap can be built to target it. The fluid... Agent: Andrew B. Brown
20110020894 - Method to facilitate recycling of biomass degrading enzymes: A strategy for enzymatic biomass conversion that involves enzyme recovery and reuse. Enzyme recovery is achieved by attaching enzymes to paramagnetic nanoparticles. By magnetically attracting the paramagnetic nanoparticles, enzymes may be recovered for reuse. The process of enzymatic biomass hydrolysis includes: attaching biomass degrading enzymes to a surface of functionalized... Agent: Fellers Snider Blankenship Bailey & Tippens
20110020895 - Methods and compositions for determining isomerase enzymatic activity: This disclosure provides crystalline flavonoid or flavanone isomerases, isolated non-native isomerase having the structural coordinates of said crystalline isomerase, and nucleic acids encoding such non-native isomerase. Also disclosed are methods of predicting the activity and/or substrate specificity of a putative isomerase, methods of identifying potential ismerase substrates, and methods of... Agent: Foley & Lardner LLP
20110020896 - Mutant dna polymerases and their genes: The present invention relates to mutant DNA polymerases, their genes and their uses. More specifically, the present invention relates to mutant DNA polymerases which are originally isolated from Thermococcus sp NA1. strain and produced by site-specific mutagenesis, their amino acid sequences, genes encoding said mutant DNA polymerases, their nucleic acids... Agent: Clark & Elbing LLP
20110020897 - Rna-dependent dna polymerase from geobacillus stearothermophilus: The invention provides an isolated polynucleotide sequence from the genome of Bacillus stearothermophilus (Geobacillus stearothermophilus) and an amino acid sequence encoded by the polynucleotide sequence, the corresponding amino acid sequence comprising a novel enzyme, Tirt (thermostable intron reverse transcriptase), having reverse transcriptase activity and retaining that activity at temperatures of... Agent: Donna J. Russell
20110020898 - Thermostable nucleic acid polymerase from thermococcus gorgonarius: A purified thermostable enzyme is derived form the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant, retains approximately 90% of its activity after incubation for two hours at 95° C. in the presence of stabilizing agents and possesses 3′-5′ proofreading exonuclease activity. Thermostable DNA polymerases are useful... Agent: Townsend And Townsend And Crew, LLP
20110020899 - Glucoamylase variants with altered properties: The present invention relates to variant glucoamylases wherein the variant has altered properties (e.g., improved thermostability and/or specific activity) compared to a corresponding parent glucoamylase. The present invention also relates to enzyme compositions comprising a variant glucoamylase (e.g., starch hydrolyzing compositions); DNA constructs comprising polynucleotides encoding the variants and methods... Agent: Danisco US Inc. Attention: Legal Department
20110020900 - Lactobacillus acidophilus nucleic acid sequences encoding protease homologues and uses therefore: Protease-like nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, protease-like fusion proteins, antigenic peptides, and anti-protease-like antibodies are encompassed. The invention also provides vectors containing a nucleic acid molecule of the invention and cells into which the vectors have been... Agent: Alston & Bird LLP
20110020902 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110020903 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110020904 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110020905 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110020906 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110020901 - Methods of making viral particles having a modified cell binding activity and uses thereof: The present invention relates to a method for packaging viral particles such that one or more peptides on the surface of the virus particle are derived from the packaging cell. By incorporating certain peptides it is possible to target viral particles to specific cell types. Such a system is of... Agent: Nikolai & Mersereau, P.A.
20110020907 - Viruses lacking epithelial cell receptor entry: The document provides nucleic acids, polypeptides, and viruses containing nucleic acids and/or polypeptides. The document also provides methods for using viruses to treat cancer patients. Specifically, the document provides nucleic acid molecules encoding viral hemagglutinin (H) polypeptides, viral H polypeptides, and viruses containing nucleic acids and/or H polypeptides. Such viruses... Agent: Fish & Richardson P.C. (tc)
20110020908 - Monoparamunity inducers based on attenuated rabbit myxoma viruses: The present invention relates to monoparamunity inducers based on paramunizing viruses or viral components of a myxomavirus strain from rabbits with typically generalizing disease, to a method for the production thereof and to the use thereof as medicaments for the regulatory optimization of the paramunizing activities for the prophylaxis and... Agent: Law Office Of Salvatore Arrigo
20110020909 - Methods of culturing lawsonia intracellularis: The present invention relates generally to the growth of Lawsonia intracellularis in non-mammalian cells and the production of the bacteria on a large scale.... Agent: Pfizer Inc Mary J Hosley
20110020910 - Methods and compositions for improving sugar transport, mixed sugar fermentation, and production of biofuels: The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods... Agent: Morrison & Foerster LLP
20110020911 - Solubilization and purification of a target protein fused to a mutant maltose-binding protein: Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein.... Agent: Harriet M. Strimpel, D. Phil.
20110020912 - Method for the construction of randomized gene sequence libraries in cells: An in vivo method for the construction of randomized gene libraries and/or domain replacement in gene libraries by homologous recombination using a Kluyveromyces lactis killer toxin, in particular the γ-subunit of the K. lactis killer toxin, as negative selection marker is described. The use of the γ-subunit of K. lactis... Agent: Alcon
20110020913 - Process for the production of algal biomass with a high lipid content: The invention relates to a process for the production of algal biomass with a high lipid content, comprising: (a) the production of inocula in order to effect phase (b), in photoreactors; (b) the massive cultivation of the algal biomass in open ponds, inoculated with phase (a); (c) a thickening phase... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110020914 - Methods for enhancing growth of organisms in an aqueous growth medium: The present invention encompasses a method for enhancing the growth, lipid content and/or protein content of bacteria, microalgae, and fungus grown in an aquatic growth medium.... Agent: Polsinelli Shughart PC
20110020915 - Extraction of co2 gas: A photo-bioreactor is used for extraction of carbon dioxide from exhaust gases of an engine used for compression of natural gas by providing a series of vessels and in each contacting the gases with a labyrinthine flow of water containing photo-synthetic organisms. Each vessel receives the gases in series and... Agent: Ade & Company Inc.
20110020916 - Extraction of co2 gas: A photo-bioreactor is used for extraction of carbon dioxide from exhaust gases of an engine used for compression of natural gas by providing a series of vessels and in each contacting the gases with a labyrinthine flow of water containing photo-synthetic organisms. Each vessel receives the gases in series and... Agent: Ade & Company Inc.
20110020917 - Nanofibers containing latent reactive groups: A nanofiber is formed by combining one or more natural or synthetic polymeric materials and one or more than one cross-linking agents having at least two latent reactive activatable groups. The latent reactive activatable nanofiber may be used to modify the surface of a substrate by activating at least one... Agent: Fulbright & Jaworski L.L.P. Attn: Mnipdocket
20110020919 - Automated liquid handling device and associated assay unit: The present invention provides a novel system for efficiently and accurately analyzing targets in samples and for preparing samples for analysis with various analytical methods. A version of the present invention comprises a multi-function probe, configured for pipetting liquids directly, with a pipet tip, or with an assay unit described... Agent: Intellectual Property Dept. Dewitt Ross & Stevens Sc
20110020920 - Microfabricated integrated dna analysis system: Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cycling chambers. A microreactor element may include a microcarrier element carrying the multiple copies of the... Agent: Weaver Austin Villeneuve & Sampson LLP
20110020918 - Microfluidic assay devices and methods: A microfluidic device adapted to perform many simultaneous binding assays including but not limited to immunological experiments, such as ELISA assays, with minimal cross-talk between primary and secondary antibodies.... Agent: Townsend And Townsend And Crew, LLP
20110020921 - Nucleic acid amplification reaction station for disposable test devices: An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20110020922 - Bioreactor: The invention relates to a bioreactor for cultivating cells having a filter bag for separating culture fluid and cells, the filter medium of the filter bag having a degree of swelling of less than 1%. The bioreactor according to the invention is characterized by a high durability of the filter... Agent: Hespos & Porco LLP
20110020923 - Multilayer tissue culture vessel: The present invention discloses a vessel for culturing cells which includes: a bottom including a base with an upwardly extending wall at least partially bounding the base of the bottom; a top including a base with a downwardly extending wall at least partially bounding the base of the top; a... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20110020924 - Highly pure plasmid dna preparations: The present disclosure generally relates to highly pure plasmid compositions having low, or undetectable, levels of colanic acid and other contaminants. The compositions described herein have a range of uses, including diverse applications in the field of bioterrorism, environmental science, food science, forensics, molecular biology, and health and medicine.... Agent: Chalker Flores, LLP
20110020925 - New modulating molecules for an improved regulated expression system: The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and... Agent: Barbara A. Shimei Director, Patents & Licensing
20110020926 - Novel taste-modifying polypeptide nas, dna thereof and use thereof: (B) a polypeptide comprising an amino acid sequence with the substitution, deletion, insertion, addition or inversion of one or several amino acids in the amino acid sequence shown in SEQ ID NO. 2 in the sequence listing, which polypeptide can form the neoculin dimer having a taste-modifying activity together with... Agent: Antonelli, Terry, Stout & Kraus, LLP
20110020928 - Immunovectors which can be used for the intracellular and intranuclear transport: A method of transferring a biologically active principle of interest into a cell by coupling an antibody or a fragment of an antibody, which recognizes an epitope contained in a nucleic acid, with the biologically active principle, to form a coupled biologically active principle; and incubating the coupled biologically active... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110020929 - Partially active microfluidic system for 3d cell cultivation and method for perfusion thereof: The invention relates to a partially active microfluidic system for cell cultivation comprising a multiwell system (4) with multiple wells (17) and cavities formed therein that hold cells. Each cavity (11) is formed by at least one inlay (3) comprising an opening (1) that does not open up directly into... Agent: Mayer & Williams PC
20110020930 - Enrichment of stem cells from adult tissues: Subjecting a heterogeneous cell population (one with both stem cells and non-stem cells) to extreme stress selectively eliminated the non-stem cells and resulted in the enrichment of stem cells in the population. The stress can take many forms, including without limitation, cell toxins, high temperature, high salt, and low oxygen... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p
20110020931 - Proliferation promoting agent for neural stem cells: A proliferation promoting agent for neural stem cells, which comprises a compound produced by Penicillium sp. CND1007 (FERM BP-10917) or a pharmaceutically acceptable salt thereof, as an active ingredient; a novel compound produced by Penicillium sp. CND 1007 or a pharmaceutically acceptable salt thereof; a method for producing neural stem... Agent: Sughrue-265550
20110020932 - In vitro differentiation/induction of lymphocyte from stem cell having genotype provided after gene reconstitution: The present invention provides a production method of a functional differentiated cell having a post-rearrangement genotype of a particular antigen receptor gene, which includes culturing a stem cell having the genotype in a medium to give the differentiated cell derived from the stem cell. As the stem cell having the... Agent: Leydig Voit & Mayer, Ltd
20110020933 - Method and device for receiving biological cells from a stem cell culture: A method for receiving biological cells (1, 2) from a cell culture (3) includes the steps: cultivation of the cell culture on a main substrate (10), cell transfer from the main substrate (10) onto at least one receiving substrate (20, 20.1, 20.2, 20.3, 20.4 . . . ), wherein the... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
20110020934 - Fusion partner for production of monoclonal rabbit antibodies: The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, in certain embodiments, an altered immunoglobulin heavy chain-encoding gene. A hybridoma resulting from... Agent: Bozicevic, Field & Francis LLP
20110020935 - Method of gene transfer into cells using electrospray and apparatus therefor: The present invention provides a method whereby, in transferring a gene into a cell by contacting the cell with a gene to be transferred into the cell in a container and then electrospraying a spray liquid free from the gene on the cell and gene in the container, the gene... Agent: Fitch, Even, Tabin & Flannery
20110020937 - Flocculent yeast and method for production thereof: It is to provide a novel Kluyveromyces marxianus transformant having thermotolerance and flocculation property, suitable for the industrial production of bioethanol, by introducing a foreign flocculation gene into Kluyveromyces marxianus, and an efficient method for producing the transformant. The present inventors focused on the flocculation gene FLO of Saccharomyces cerevisiae... Agent: Venable LLP
20110020936 - Method for electroporation of lactobacillus buchneri with nucleic acid: Electroporation methods for transferring a nucleic acid of interest, including ferulic acid esterase nucleic acid, into bacterial host cells, such as Lactobacillus spp. are disclosed. Compositions of transformed bacterial host cells, such as transformed Lactobacillus buchneri, and use assays are provided.... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.
20110020938 - Recombinant expression plasmid vector and recombinant strain to be used in producing oxalate decarboxylase, and method of producing recombinant oxalate decarboxylase: An object is to provide a means of highly producing an oxalate decarboxylase originating in a microorganism. A recombinant expression plasmid vector, which contains an α-amylase promoter belonging to the genus Bacillus and an oxalate decarboxylase gene originating in a microorganism that is provided under the control of the promoter,... Agent: Edwards Angell Palmer & Dodge LLP01/20/2011 > 113 patent applications in 66 patent subcategories. recently filed with US Patent Office
20110014597 - Perfusable bioreactor for the production and/or cultivation of a human or animal blood vessel and/or a human or animal tissue: A bioreactor for the production and/or cultivation of a human or animal blood vessel and/or a human or animal tissue contains at least one tubular base body having two front sides. The bioreactor further has a reclosable liquid-tight opening which is arranged on one front side, an inner space, a... Agent: Lerner Greenberg Stemer LLP
20110014600 - Microfluidic magnetophoretic device and methods for using the same: A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally includes separate buffer and sample streams. A magnetic field gradient applied to the sorting station deflects the flow path of... Agent: Bozicevic, Field & Francis LLP
20110014599 - Novel fluorescent dyes and uses thereof: The present invention provides fluorescent dyes that are based on firefly luciferin structure. These dyes are optimally excited at shorter wavelengths and have Stokes shift of at least 50 nm. The fluorescent dyes of the invention are useful for preparation of dye-conjugates, which can be used in detection of an... Agent: Beckman Coulter, Inc. Mitchell E. Alter
20110014598 - Optimized probes and primers and method of using same for the detection of herpes simplex virus: Described herein are primers and probes useful for detecting and typing variant HSV strains, and methods of using the described primers and probes.... Agent: Foley & Lardner LLP
20110014606 - Assays: A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed... Agent: Steptoe & Johnson LLP
20110014610 - Compositions and methods for diagnosing and treating neuropsychiatric disorders: The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia and mood disorders such as major depression disorder and bipolar disorder). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering... Agent: Townsend And Townsend And Crew, LLP
20110014611 - Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequences by synthesis: This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.... Agent: Cooper & Dunham, LLP
20110014621 - Detecting multinucleotide repeats: Methods of determining the length of a multinucleotide repeat region in a target nucleic acid are provided herein which include labeling amplified target nucleic acids with a target detection label independent of the number of multinucleotide repeats and a repeat-detection label proportional to the number of multinucleotide repeats, wherein the... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.
20110014618 - Detection of nucleic acids and proteins: The invention generally relates to methods for detecting a target nucleic acid and a target protein in a single assay.... Agent: Brown Rudnick LLP
20110014602 - Diagnostic composition for hepatocellular carcinoma, a diagnostic kit comprising it and diagnostic methods of hepatocellular carcinoma: In the present invention, it is confirmed that cystatin B (cystatin B, CSTB) can be used as a diagnostic marker for hepatocellular carcinoma. Accordingly, the invention relates to a method for early diagnosing hepatocellular carcinoma using the cystatin B as a diagnostic marker for hepatocellular carcinoma, a method for determining... Agent: Ohlandt, Greeley, Ruggiero & Perle, LLP
20110014622 - Genetic reference materials: The invention provides a genetic reference standard with at least one human genetic reference sequence (having a human DNA sequence containing at least one genetic variant whose presence in the DNA of a human subject is indicative of a pathological condition, a predisposition to a pathological condition, or a predisposition... Agent: Knobbe Martens Olson & Bear LLP
20110014613 - Genotyping for risk of atherosclerosis: The invention provides a kits, compositions and methods useful for determining atherosclerotic risk in a subject. In one aspect, the invention provides kit comprising a solid support comprising a capture probe set comprising a plurality of probes selected from (a) a probe selective for PTGS1, (b) a probe selective for... Agent: Morgan, Lewis & Bockius, LLP (sf)
20110014607 - Imprinted genes and disease: Methods for identifying imprinted genes. In some embodiments, the methods comprise (a) providing a first data set comprising a plurality of nucleic acid sequences, wherein the nucleic acid sequences comprise genomic DNA sequences corresponding to a plurality of genes known to be imprinted in the subject; (b) providing a second... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20110014615 - Method for diagnosing non-small cell lung cancers by trna-dihydrouridine synthase activity of urlc8: The present invention features a method for determining t-RNA dihydrouridine-synthase activity of a polypeptide and screening for modulators of t-RNA dihydrouridine-synthase activity. The present invention further provides methods or pharmaceutical compositions for preventing and/or treating non-small cell lung cancer (NSCLC) using such modulators. Furthermore, the present invention provides methods for... Agent: Townsend And Townsend And Crew, LLP
20110014614 - Method of profiling gene expression in a subject having an infectious disease: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20110014617 - Methods and systems for detecting nucleic acids: Methods and kits for detecting a target nucleic acid in a sample are described. In some embodiments, the sample to be analyzed includes a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion... Agent: Life Technologies Corporation C/o Intellevate
20110014605 - Methods and systems for dna isolation on a microfluidic device: The present invention relates to methods and systems for the isolation of DNA on a microfluidic device and the subsequent analysis of the DNA on the microfluidic device. More specifically, embodiments of the present invention relate to methods and systems for the isolation of DNA from patient samples on a... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20110014620 - Methods for identification of bone anabolic agents: The present invention is related to methods for identifying bone anabolic agents and factors, identifying pathways that promote proliferation of osteoblasts for bone growth and/or repair, and for identifying new therapeutic targets for treatments for osteoporosis and other bone degenerative disorders characterized by osteopenia.... Agent: Fish & Richardson P.C. (ny)
20110014624 - Methods for identifying cells suitable for large-scale production of recombinant proteins: The present invention provides methods of identifying a clonal population of cells suitable for large-scale production of a protein of interest. The invention further provides methods for high-throughput screening for genetic rearrangements in the gene encoding the protein of interest, whereby the absence of a deletion in the gene encoding... Agent: Wyeth LLC Patent Law Group
20110014604 - Methods for sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Life Technologies Corporation C/o Intellevate
20110014609 - Nucleic acid signal enhancement using nanoparticle-based hybridization: A method of enhancing signal detection through use of nanoparticle-conjugated nucleic acid probes is provided. Following chromosomal FISH hybridization of a target sequence with a genomic probe linked to a flag sequence, the flag sequence is hybridized to an anti-flag sequence conjugated to a nanoparticle. The enhanced fluorescent probe is... Agent: Polsinelli Shughart PC
20110014612 - Polymerase compositions & methods: Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications.... Agent: Life Technologies Corporation C/o Intellevate
20110014616 - Rapid screening of biologically active nucleases and isolation of nuclease-modified cells: Disclosed herein are methods and compositions for rapidly identifying active nucleases and cells having nuclease-mediated genomic modifications.... Agent: Robins & Pasternak
20110014619 - Reaction treatment apparatus and reaction treatment method: Provided is a reaction treatment apparatus in which, in a case of mixing a plurality of solutions in a microchip used in a biochemical reaction system, an electric field generation area for changing solute concentration distribution in the solutions is provided in a solution upstream fluid path. Diffusion between the... Agent: Fitzpatrick Cella Harper & Scinto
20110014608 - Screening for cd93 (c1qrp)-associated polymorphism(s) in the diagnosis, prevention and treatment of autoimmune diseases: This invention is directed to a marker gene for autoimmune disease. Specifically, the invention is directed to the use of a polymorph of CD93 in methods and compositions for the detection, prognosis and therapy of Type I Diabetes and systemic lupus erythematosus (SLE).... Agent: Pearl Cohen Zedek Latzer, LLP
20110014625 - System and method for determining the health of a subject using polymorphic risk markers: A system and method for predicting the health of a subject comprising obtaining nucleic acid sequence data about the subject. Identifying at least one polymorphic risk marker associated with a change in promoter methylation of a gene associated with lung cancer; and predicting the health of the subject from a... Agent: Peacock Myers, P.C.
20110014623 - Tagged oligonucleotides and their use in nucleic acid amplification methods: The present invention provides nucleic acid amplification methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplification reaction and/or that may be present in the environment in which an... Agent: Gen Probe Incorporated
20110014603 - Targets for use in diagnosis, prognosis and therapy of cancer: Provided herein are targets that can be used for the diagnosis, prognosis and therapy of a variety of cancers.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20110014601 - Targeted chromosomal mutagenesis using zinc finger nucleases: The present invention provides for a method or methods of targeted genetic recombination or mutagenesis in a host cell or organism, and compositions useful for carrying out the method. The targeting method of the present invention exploits endogenous cellular mechanisms for homologous recombination and repair of double stranded breaks in... Agent: Ballard Spahr LLP
20110014628 - Identification of surface-associated antigens for tumor diagnosis and therapy: An isolated truncated desmoglein 4 (DSG4) polypeptide splice variant of the invention is characterized by an amino acid sequence that lacks a region encoded before exon 9 or beyond exon 10 of the DSG4 gene having the polynucleotide sequence of SEQ ID NO: 75. Also disclosed is a method of... Agent: Olson & Cepuritis, Ltd.
20110014627 - Method for determining antagonist activity to a cytokinin receptor: The present invention provides a method for analyzing agonist-activity to a cytokinin receptor, which comprises (1) bringing an examinee substance into contact with a transformed cell into which DNA coding the cytokinin receptor is introduced and (2) measuring the existence or the quantity of intracellular signal transduction from the cytokinin... Agent: Sughrue Mion, PLLC
20110014626 - Methods for measuring the insulin receptor alpha subunit: e
20110014630 - Fluorescent carbon nanoparticles: Disclosed are photoluminescent particles. The particles include a core nano-sized particle of carbon and a passivation agent bound to the surface of the nanoparticle. The passivation agent can be, for instance, a polymeric material. The passivation agent can also be derivatized for particular applications. For example, the photoluminescent carbon nanoparticles... Agent: Dority & Manning, P.A.
20110014629 - Methods for improving the recovery of troponin i and t in membranes, filters and vessels: A method to facilitate recovery troponin I and/or troponin T from a sample comprising addition of troponin C to the sample or to a surface from which the troponin I and/or troponin T are recovered.... Agent: Wilson, Sonsini, Goodrich & Rosati
20110014635 - Marker peptide for alzheimer's disease: To provide a peptide obtainable by cleaving an N-terminal region and a C-terminal region of Alcadein α, Alcadein β, or Alcadein γ; and capable of being a diagnostic marker for Alzheimer's disease. It is possible to detect Alzheimer's disease at an early stage without burdening subjects to be tested by... Agent: Birch Stewart Kolasch & Birch
20110014634 - Nucleic acids encoding t2r, a novel family of taste receptors: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.... Agent: Townsend And Townsend And Crew, LLP
20110014637 - Method for determining the sensitivity of patients suffering from a cancer disease to biological therapy: The invention relates to a method for determining the sensitivity of patients suffering from a cancer disease towards targeted biological therapy based on the inhibition of signaling pathways of the members of HER family (e.g., HER-1, HER-2, HER-3 and HER-4) by determining the expression of the biomarker S6 kinase or... Agent: Notaro, Michalos & Zaccaria P.C.
20110014636 - Method of detecting leukemic cell: [Means for Solving Problems] A method of detecting a leukemia cell which comprises detecting a CD34-positive cell being negative in DOCK180 expression from a blood specimen. According to this method, a DOCK180 expression pattern specific to a tumor cell in leukemia, in particular, acute leukemia is confirmed so that information... Agent: Quinn Emanuel Urquhart & Sullivan, LLP
20110014631 - Method for diagnosing acute coronary syndrome: e
20110014632 - Assays for clinical assessments of rheumatoid arthritis: The disclosure provides methods of detecting autoantibodies present in the serum of subjects suffering from rheumatoid arthritis. The methods use capture probes and detection probes that can bind to the antifilaggrin autoantibodies or other epitope related autoantibodies. The presence, absence, and/or amount of the autoantibody complex may be detected, wherein... Agent: Gregory T. Pletta Nanosphere, Inc.
20110014633 - Electric analysis method: e
20110014638 - Soluble fas in acute coronary syndromes diagnosis: The present technology provides methods and materials for the early clinical detection of acute coronary syndromes in a subject. The methods and materials comprise measuring the amount of soluble Fas in a sample obtained from a subject, comparing the amount of soluble sFas with a reference value and detecting the... Agent: Lando & Anastasi, LLP
20110014639 - Hybridoma cell line producing monoclonal antibody against foot-and-mouth disease virus, the monoclonal antibody therefrom, immunoassay reagent and kit, and immunoassay method: Provided herein are a hybridoma cell line producing monoclonal antibody against foot-and-mouth disease virus (FMDV), the monoclonal antibody therefrom, reagent and kit for ELISA, and immunoassay method. The hybridoma cell line is produced by cell fusion of a parental cell and a myeloma cell line and has the same characteristics... Agent: Sinorica, LLC
20110014640 - Blood coagulation analyzer, blood coagulation analysis method, and computer program product: A blood coagulation analyzer is provided by which, while the measurement using reagent for measuring a Fbg (fibrinogen concentration) is being minimized, the result of a measurement such as a PT measurement can be used to accurately acquire a fibrinogen concentration. The blood coagulation analyzer (1) includes a detector for... Agent: Brinks Hofer Gilson & Lione
20110014641 - Method for measuring aromatase activity: The present invention relates to compounds useful for measuring aromatase activity. The invention further provides methods for measuring aromatase activity and for screening test agents which modulate aromatase activity. A kit is also provided for use in such screening methods.... Agent: Ge Healthcare Bio-sciences Corp. Patent Department
20110014642 - Method of screening for compounds that can be used for the treatment of respiratory conditions: The present invention relates to the use of a screening method for identifying candidate molecules that can be used for the treatment of respiratory conditions in a mammal, wherein said screening method comprises a step which comprises determining whether the functional activity of a TASK-2 polypeptide in the presence of... Agent: Arent Fox LLP
20110014643 - Neuronal cells cultured on microparticles and methods of using same: The present invention provides methods for culturing neuronal cells for transplantation into a subject. The methods include culturing neuronal cells with microparticles to provide a microparticle and neuronal cell culture composition, wherein the microparticles are coated with a compound that provides for attachment of neuronal cells. The present invention also... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP
20110014644 - Methods for predicting a cancer patient's response to antifolate chemotherapy: The present invention provides methods for individualizing therapy for cancer treatment, and particularly for evaluating a patient's responsiveness to one or more antifolate therapeutic agents prior to treatment with such agents. Particularly, the invention provides an in vitro chemoresponse assay for predicting a patient's response to an antifolate agent, such... Agent: Cooley LLP Attn: Patent Group
20110014645 - Method for determining a complete blood count on a white blood cell differential count: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate... Agent: Hogan Lovells US LLPIPGroup, Columbia Square
20110014646 - Sample preparation apparatus and sample preparation method, and cell analyzer and cell analysis method: A sample preparation apparatus comprising: a detector for detecting a predetermined cell included in a biological sample; a sample preparation section for preparing a measurement sample from the biological sample and a predetermined reagent; and a controller configured to generate, based on a detection result by the detector, concentration information... Agent: Brinks Hofer Gilson & Lione
20110014647 - System and method for analyzing samples labeled with 5, 10, 15, 20 tetrakis (4-carboxyphenyl) porphine (tcpp): One embodiment of the present invention provides for a method of determining if a sputum sample contains dysplastic or carcinomic cells by obtaining a sputum sample containing cells. The sputum sample is labeled with TCPP to stain cells suspected to be dysplastic or carcinomic. The labeled sputum sample is excited... Agent: Peacock Myers, P.C.
20110014648 - A microbiological production method and equipment for its use: When using the equipment and method in accordance with this invention, it is possible to implement biotechnological production e.g. in biorefineries in such a way that it is possible to make use of the phenomena of the gas-liquid interface and interfaces between other phases by means of a moving process... Agent: David A. Guerra International Patent Group, LLC
20110014650 - In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris: The invention provides orthogonal translation systems for the production of polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris. Methods for producing polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris are also provided.... Agent: Quine Intellectual Property Law Group, P.C.
20110014651 - Method for high-level secretory production of protein: This invention provides a means for high-level secretory production of a protein, and, in particular, a protein having a complicated structure such as an antibody, in a host cell such as a yeast cell. This invention provides a method for high-level secretory production of a foreign protein with the use... Agent: Sughrue Mion, PLLC
20110014649 - Method for production of n36-binding peptide: The present invention relates to the production of an N36-binding peptide at low cost and in a large quantity utilizing a microorganism. More specifically, the present invention relates to a method for producing an N36-binding peptide comprising introducing a recombinant vector into which a DNA molecule encoding an N36-binding peptide... Agent: Greenblum & Bernstein, P.L.C
20110014652 - Norovirus and sapovirus antigens: Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods... Agent: Novartis Vaccines And Diagnostics Inc.
20110014653 - Production of antibodies in avian cells: The present invention relates generally to novel methods of producing immunoglobulin polypeptides. More specifically, the invention relates to methods of inserting immunoglobulin-encoding transgenes into avian cells for immunoglobulin production. In one embodiment, the transgenes include at least two immunoglobulin-encoding nucleic acid sequences and an internal ribosome entry site (IRES).... Agent: Synageva Biopharma Corp.
20110014655 - Selection of host cells expressing protein at high levels: The invention provides a DNA molecule comprising a multicistronic transcription unit coding for i) a selectable marker polypeptide functional in a eukaryotic host cell, and for ii) a polypeptide of interest, the polypeptide of interest having a translation initiation sequence separate from that of the selectable marker polypeptide, characterized in... Agent: Traskbritt, P.C.
20110014656 - Soluble il-17ra/rc fusion proteins and related methods: Disclosed are antagonists of IL-17A and IL-17F. The antagonists are based on soluble IL-17RA and IL-17RC fusion proteins, including hybrid soluble receptors comprising portions of both IL-17RC and IL-17RA (“IL-17RC/IL-17RA”). Such antagonists serve to block, inhibit, reduce, antagonize or neutralize the activity of IL-17F, IL-17A, or both IL-17A and IL-17F.... Agent: Townsend And Townsend And Crew LLP
20110014657 - Method for sequencing a polynucleotide template: The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. Using the methods of the invention it is possible to obtain two linked or paired reads of... Agent: Klauber & Jackson
20110014658 - Compositions and method for storage of nucleic acid from bodily fluids: The present invention provides an aqueous composition and method for extracting nucleic acid from a sample of bodily fluid, such as saliva, such that the nucleic acid within said sample remains stable for at least fourteen days at room temperature. The composition permits direct use of the extracted and stored... Agent: Osler, Hoskin & Harcourt LLP (other)
20110014659 - Isolation of unknown rearranged t-cell receptors from single cells: Disclosed herein are methods and materials for isolating and identifying T cell receptors from single cells. In some embodiments, genomic DNA from a single T cell is isolated using whole genome amplification (WGA). A series of PCR reactions is carried out to enrich the genomic template for sequences encoding the... Agent: Knobbe Martens Olson & Bear LLP
20110014660 - Thermostable dna polymerase from palaeococcus ferrophilus: There is provided a polypeptide having thermostable DNA polymerase activity and comprising or consisting of an amino acid sequence with at least 90% identity to Palaeococcus ferrophilus DNA polymerase shown in SEQ ID NO: 1.... Agent: Hunton & Williams LLP Intellectual Property Department
20110014661 - Method of producing sialylated oligosaccharides: The present invention relates to a method for the large scale in vivo synthesis of sialylated oligosaccharides, culturing a microorganism in a culture medium, optionally comprising an exogenous precursor such as lactose, wherein said microorganism comprises heterologous genes encoding a CMP-Neu5Ac synthetase, a sialic acid synthase, a GlcNAc-6-phosphate 2 epimerase... Agent: Foley And Lardner LLP Suite 500
20110014662 - Methods for producing hyaluronan in a recombinant host cell: The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a Bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein the Bacillus host cell comprises a nucleic acid construct comprising a hyaluronan synthase encoding sequence operably linked to a promoter sequence foreign... Agent: Novozymes, Inc.
20110014663 - Method for producing an l-amino acid: An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability in a medium containing a processed product of a microalga which promotes production and accumulation of the L-amino acid by the bacterium. The process product is produced by disrupting the culture of the microalga, and/or extracting... Agent: Cermak Nakajima LLP Acs LLC
20110014664 - fermentation process for higher yield coefficient of lipase-inhibitor with respect to consumed fatty acid: The invention provides a process for the production of lipase inhibitors via an improvised fermentation process characterized in that a combinatorial feeding of linoleic acid or its esters or salts thereof and an omega-9 fatty acid, preferably oleic acid and/or its derivatives is employed during said process resulting in an... Agent: Dla Piper LLP (us)
20110014665 - Production of oil in microorganisms: The invention provides methods of cultivating oil-bearing microbes using cellulosic material. Also provided are microorganisms containing one or more exogenous genes that facilitate the use of cellulosic materials as a feedstock. Also provided are microorganisms and methods for manufacturing non-alcohol-based fuels and fuel feedstocks through a process of converting cellulosic... Agent: Alston & Bird LLP/ Solazyme, Inc
20110014667 - Producing dicarboxylic acids using polyketide synthases: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.... Agent: Townsend And Townsend And Crew, LLP
20110014668 - Organisms for the production of cyclohexanone: A non-naturally occurring microbial organism has cyclohexanone pathways that include at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. A pathway includes a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on C—C bond), a 2-ketocyclohexane-1-carboxylate decarboxylase and an enzyme selected from a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxyl-CoA transferase, and a... Agent: Mcdermott, Will & Emery LLP
20110014669 - Production of 1,4 butanediol in a microorganism: A biological method for the conversion of L-glutamate to 1,4-butanediol that involves a decarboxylation step and avoids production of 4-hydroxybutyrate as an intermediate is described. The method includes: (a) conversion of L-glutamate to L-glutamate 5-phosphate; (b) conversion of L-glutamate 5-phosphate to L-glutamate 5-semialdehyde; (c) conversion of L-glutamate 5-semialdehyde to 5-hydroxy-L-norvaline;... Agent: Fish & Richardson P.C. (bo)
20110014671 - Method for obtaining bioethanol from sorghum grain (sorghum bicolor l. moench), comprising steps involving decortication and hydrolysis with proteases: The invention relates to an improved method for obtaining bioethanol from sorghum grain (Sorghum bicolor L. Moench), comprising steps involving decortication and hydrolysis with proteases prior to liquefaction. The decortication is performed mechanically and produces a by-product rich in pericarp or bran and stable sorghum grain. The decorticated grain produces... Agent: Baker & Mckenzie LLP
20110014670 - Zymomonas with improved xylose utilization in stress conditions: Strains of xylose utilizing Zymomonas with improved xylose utilization and ethanol production during fermentation in stress conditions were obtained using an adaptation method. The adaptation involved continuously growing xylose utilizing Zymomonas in media containing high sugars, acetic acid, ammonia, and ethanol.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110014672 - Isoprene production using the dxp and mva pathway: The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells.... Agent: Morrison & Foerster LLP
20110014673 - Systems and methods for effecting a physical change in a biological sample: The present invention relates generally to systems and methods for processing a biological sample that result in a physical change, such as reacting two molecules together to form a reaction product or for use in lysing viruses or biological cells for analysis using biological assay systems. As such, the present... Agent: Woodcock Washburn LLP
20110014674 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110014675 - Poly zinc finger proteins with improved linkers: Polynucleotides encoding chimeric proteins, and methods for their production and use are disclosed. The chimeric proteins comprise a flexible linker between two zinc finger DNA-binding domains, wherein the linker contains eight or more amino acids between the second conserved histidine residue of the carboxy-terminal zinc finger of the first domain... Agent: Robins & Pasternak
20110014676 - Protein stabilization: A method and formulation for temperature stabilization of proteins, such as antibodies, enzymes such as Taq poly-merase, restriction enzymes, and other diagnostic or therapeutic enzymes using a combination of first and second stabilizers.... Agent: Battelle Memorial Institute
20110014677 - Novel dna fragment, recombinant vector comprising same, transformant transformed therewith, and use thereof: A DNA fragment containing a gene which encodes a specific gene regulatory region alone or the gene regulatory region together with a signal peptide; a recombinant vector containing the DNA fragment; a transformant containing the recombinant vector; and a method of producing a recombinant protein by using the transformant. According... Agent: Jacobson Holman PLLC
20110014679 - Dna replication factors: A DNA polymerase reaction system which provides high DNA polymerase activity even at a high temperature and at a high salt concentration. A DNA polymerase reaction system that is constructed from a DNA polymerase, a clamp, and a clamp loader without intein sequence, the DNA polymerase being from Pyrococcus horikoshii,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110014678 - Sulfotransferase 1e1 sequence variants: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described.... Agent: Fish & Richardson P.C. (tc)
20110014680 - Crystal structure of human jak3 kinase domain complex and binding pockets thereof: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of... Agent: Ropes & Gray LLP
20110014681 - Glucoamylase variants: The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (SBD) of a glucoamylase. The invention also relates to variants having altered properties (e.g., improved thermostability and/or increased specific activity) as compared to a corresponding parent glucoamylase. The present invention also... Agent: Danisco US Inc. Attention: Legal Department
20110014682 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110014683 - System and method for growing photosynthetic cells: Disclosed are a system and method for growing photosynthetic cells in conduit. The system and method supply light, CO2 and nutrients to the cells. The system and method also dampen thermal variations in the conduit.... Agent: Fulbright & Jaworski L.L.P.
20110014684 - Method for wastewater treatment and wastewater treatment system: The invention relates to a method for wastewater treatment utilizing an anaerobic treatment of primary sludge (PS) in a septic tank (5), and a separate treatment of excess sludge (US). The excess sludge (US) is separated from the primary sludge (PS) before the anaerobic treatment, solubilized in a hydrolysis treatment... Agent: Whitham, Curtis & Christofferson & Cook, P.C.
20110014685 - Cell processing apparatus, sample preparation apparatus, and cell analyzer: A cell processing apparatus 29 of the present invention includes a storage container 57 that can contain liquid L including a biological sample; a filter 60 that prevents a first cell C1 in the biological sample from passing therethrough and that allows a second cell C2 having a smaller diameter... Agent: Brinks Hofer Gilson & Lione
20110014686 - Method and apparatus for imaging target components in a biological sample using permanent magnets: A system for enumeration of cells in fluids by image cytometry is described for assessment of target populations such as leukocyte subsets in different bodily fluids or bacterial contamination in environmental samples, food products and bodily fluids. Briefly, fluorescently labeled target cells are linked to magnetic particles or beads. In... Agent: Immunicon Corporation
20110014687 - Connection device and analyzer: A connection device for connecting to a plurality of fluid containers that have openings, and a sample analyzer body for analyzing samples using reagent, is disclosed, which comprises: a plurality of tubular members for passing liquid, the plurality of tubular members being inserted in the fluid containers through the openings... Agent: Brinks Hofer Gilson & Lione
20110014688 - Pico liter well holding device and method of making the same: The present invention broadly comprises a holding device for studying cells comprising at least one cavity adapted to receive cells in a medium consisting essentially of water, the cavity having a substrate and a generally inert wall, wherein the substrate includes a surface for receiving the medium, and wherein the... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20110014689 - disposable bio-reactor system: A disposable bioreactor system with a focus on improving cell culture technology by introducing a disposable bioreactor bag which operates or functions in conjunction with a unique mechanism of external non-rotating gyrating motion that uses gravity in a natural way to make the fluid flow circumferentially in it. The bioreactor... Agent: Ravindranath Gandlur
20110014690 - Cornea storage container to maximize cornea health: An apparatus for shipping, storing, and viewing a cornea. The device offers an improvement to cornea health relative to conventional cornea containers.... Agent: Patterson Thuente Christensen Pedersen, P.A.
20110014691 - Method for generating primate cardiovascular progenitor cells for clinical use from primate embryonic stem cells or embryonic-like state cells, and their applications: The present invention is directed to a method for the in vitro preparation of cardiovascular progenitors cells from mammalian embryonic stem cells (ES cells) or mammalian embryonic-like state cells, preferably from primate, wherein said method comprises the use of the CD15 (SSEAI) marker as a positive cardiovascular progenitors differentiation marker.... Agent: Buchanan, Ingersoll & Rooney PC
20110014692 - Method of deriving progenitor cell line: We disclose a method comprising: (a) providing an embryonic stem (ES) cell; and (b) establishing a progenitor cell line from the embryonic stem cell; in which the progenitor cell line is selected based on its ability to self-renew. Preferably, the method selects against somatic cells based on their inability to... Agent: Cohen & Grigsby, P.C.
20110014693 - Microcarriers for stem cell culture: We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50... Agent: Swanson & Bratschun, L.L.C.
20110014694 - Use of enteric glia: Methods of reducing tissue damage in the nervous system are disclosed. The methods involved administering enteric glial cells to an animal with a nerve injury. Methods of improving locomotor function in animal with a nerve injury are also disclosed.... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.
20110014695 - Methods for obtaining adult human olfactory progenitor cells: An isolated human olfactory stem cell can be prepared by culturing human tissue from olfactory neuroepithelium to form neurospheres.... Agent: Fish & Richardson P.C. (tc)
20110014696 - Method for producing dendritic cells: Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of providing a population of embryonic stem cells; culturing the embryonic... Agent: Bozicevic, Field & Francis LLP
20110014697 - Method and kit for rapid isolation of human foxp3+ treg cells: The present invention relates to methods for isolating human forkhead box P3 (Foxp3+) CD4+ regulatory T cells (herein referred to as Foxp3+ Treg cells) from a sample containing (i) peripheral blood mononuclear cells (PBMCs), (ii) a lymphocyte containing fluid, or (iii) a lymphocyte containing tissue, a kit for isolating human... Agent: Licata & Tyrrell P.C.
20110014699 - Prostratin analogs, bryostatin analogs, prodrugs, synthetic methods, and methods of use: Embodiments of the present disclosure provide for prostratin analogs, bryostatin analogs, prodrugs of prostratin and prostratin analogs, methods of making prostratin analogs, and methods of making prodrugs of prostratin and prostratin analogs, methods of use of prostratin analogs, bryostatin analogs, and prodrugs thereof, and the like.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP
20110014698 - Use of nanopatterned surfaces and method for enriching or isolating cellular subpopulations: The invention relates to the use of nanopatterned surfaces. It also relates to a method for enriching or isolating cellular subpopulations. To create a simple, versatile and specific method for enriching or isolating cellular subpopulations from a complex mixture, the invention proposes the use of nanopatterned surfaces for isolating and... Agent: Collard & Roe, P.C.
20110014700 - Methods of storing and providing samples of cells and tissue: A cell or tissue sample from a donor is stored in bank wherein the donor can initially determine the sample status to (a) exclusively retain, (b) make public, or (c) optionally make public his cells or tissue. Where the donor opts for optional public storage, the donor may in response... Agent: Fish & Associates, PC Robert D. Fish
20110014701 - Protection of progenitor cells and regulation of their differentiation: The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20110014702 - Differentiation of human embryonic stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells capable of producing insulin following transplantation into an animal.... Agent: Philip S. Johnson Johnson & Johnson
20110014703 - Differentiation of human embryonic stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells into cells expressing markers characteristic of the pancreatic endocrine lineage that co-express PDX1, NKX6.1, but do not express CDX2 and NGN3.... Agent: Philip S. Johnson Johnson & Johnson
20110014704 - Isolation of multi-lineage stem cells: The present application discloses a method of manipulating a biological sample of cells, which includes multi-lineage stem cells, progenitor cells, other marrow stromal cells: allowing the sample of cells to settle in a container; transferring supernatant from the container to another container; and isolating cells from the supernatant, which has... Agent: Jhk Law
20110014705 - Method and apparatus for separating biological materials: According to various embodiments, a system can be provided to separate undifferentiated cells and/or stromal cells from a whole tissue sample. The whole tissue sample can be any appropriate tissue sample obtained directly from a patient. The tissue sample can be obtained during a selected operating procedure for immediate or... Agent: Harness, Dickey & Pierce, P.L.C
20110014706 - Arabidopsis thaliana genome sequence and uses thereof: The present invention relates to nucleic acid sequences from the dicotyldonus plant Arabidopsis thaliana and, in particular, to genomic DNA sequences. The invention encompasses nucleic acid molecules present in non-coding regions as well as nucleic acid molecules that encode proteins and fragments of proteins. In addition, proteins and fragments of... Agent: Arnold & Porter LLP
20110014707 - Polypeptides having endoglucanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes, Inc.
20110014708 - Nucleic acid for use in algae and use thereof: The present invention provides a modified nucleic acid for expressing bovine lactoferricin (LFB) in algae, which consists of SEQ ID NO: 3. The present invention also provides a method of producing a foreign desired gene product in algae, comprising: (a) weakening or removing cell wall of the algae by a... Agent: Wpat, PC Intellectual Property Attorneys
20110014709 - Method of modifying target region in host dna and selectable marker cassette: a second step of performing homologous recombination, within the host DNA integrated with the donor DNA by the first step, between two regions of the 3′-side region derived from the host DNA and the 3′-side region derived from the donor DNA, to conduct selection of a host whose target region... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.01/13/2011 > 134 patent applications in 61 patent subcategories. recently filed with US Patent Office
20110008762 - Methods for preserving organs and tissues: The invention relates to a method for preserving an organ or tissue comprising contacting the organ or tissue with an effective amount of a kallikrein inhibitor and solutions useful for such a method. Also provided is a method for reducing reperfusion injury of an organ during surgery and/or following removal... Agent: Lando & Anastasi, LLP
20110008763 - Materials and methods for flushing and cold/cryo preserving organs, tissues, and cells: Materials and methods for preserving biological materials (e.g., organs, tissues, and cells) under cold or cryo conditions while reducing or minimizing damage to the materials.... Agent: Fish & Richardson P.C. (tc)
20110008764 - Human gonadal stem cells: Adult human gonadal stem cells that are capable of differentiating into cells of the mesodermal lineage and ectodermal lineage are described.... Agent: Fish & Richardson P.C. (ny)
20110008766 - Dual variable domain immunoglobulins and uses thereof: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.... Agent: Abbott Bioresearch
20110008767 - Microfluidic device: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices allow light collection from multiple directions. In certain other embodiments, the microfluidic devices use spatial intensity modulation. In certain other embodiments, the microfluidic devices have magnetic field separators.... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP Sony Corporation
20110008768 - Oligonucleotides and methods for detection of west nile virus: The invention provides methods of detecting West Nile virus and oligonucleotide reagents derived from a West Nile virus consensus sequence that are useful in the methods of the invention.... Agent: Connolly Bove Lodge & Hutz, LLP
20110008765 - Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications: The present invention generally relates to a combination of the fields of tissue engineering, drug discovery and drug development. It more specifically provides new methods and materials for testing the efficacy and safety of experimental drugs, defining the metabolic pathways of experimental drugs and characterizing the properties (e.g., side effects,... Agent: Edwards Angell Palmer & Dodge LLP
20110008788 - Chemically modified ligase cofactors, donors and acceptors: Provided herein are methods for ligation of polynucleotides containing modified ligation components, particularly modified ligase cofactors, modified acceptors and modified donors. The methods readily applied to ligation-based assays for detection of a nucleic acid sequence where the use of the modified cofactor improves discrimination between matched and mismatched templates. Furthermore,... Agent: Foley & Lardner LLP
20110008770 - Compositions and methods for reverse transcription of nucleic acid molecules: The present invention is generally related to compositions and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to compositions comprising mixtures of polypeptides having reverse transcriptase (RT) activity, and to methods of producing, amplifying or sequencing nucleic acid molecules (particularly cDNA... Agent: Life Technologies Corporation C/o Intellevate
20110008790 - Cystic fibrosis transmembrane conductance regulator gene mutations: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further... Agent: Foley & Lardner LLP
20110008787 - Detection primers for nucleic acid extension or amplification reactions: Disclosed are methods and compositions related to real-time PCR and other nucleic acid extension or amplification reactions.... Agent: Knobbe Martens Olson & Bear LLP
20110008769 - Dopaminergic neuron progenitor cell marker 187a5: An object of the present invention is to provide a probe, a primer, a primer set and an antibody for use in the detection or selection of a dopaminergic neuron progenitor cell. The present invention provides a probe, a primer and a primer set for use in the detection or... Agent: Townsend And Townsend And Crew, LLP
20110008783 - Fluorimetric process for evaluating the influence of a condition on a biological sample, and applications thereof: The present invention relates to a process for determining the influence of a condition on a biological sample comprising a step consisting in establishing the kinetic profile of the fluorescence emitted, during the excitation at a suitable excitation wavelength, of a fluorescent compound bound to said biological sample, said sample... Agent: Miles & Stockbridge PC
20110008794 - High speed parallel molecular nucleic acid sequencing: A method and device is disclosed for high speed, automated sequencing of nucleic acid molecules. A nucleic acid molecule to be sequenced is exposed to a polymerase in the presence of nucleotides which are to be incorporated into a complementary nucleic acid strand. The polymerase carries a donor fluorophore, and... Agent: Klarquist Sparkman, LLP (ott-nih)
20110008776 - Integrated separation and detection cartridge using magnetic particles with bimodal size distribution: The present invention relates to a device and a method for quantitative detecting of the presence or absence of a target analyte in a liquid sample, the device comprising a reaction chamber having a volume of less than 200 μl comprising an immobilization matrix capable of capturing the analyte, said... Agent: The Nath Law Group
20110008781 - Isothermal amplification of nucleic acids on a solid support: Methods for isothermal amplification of nucleic acid by means of a solid support are disclosed. These methods are useful for applications needing high throughput, in particular nucleic acid sequencing.... Agent: Illumina, Inc. Legal Department
20110008793 - Maize polymorphisms and methods of genotyping: Polymorphic maize DNA loci useful for genotyping between at least two varieties of maize. Sequences of the loci are useful for designing primers and probe oligonucleotides for detecting polymorphisms in maize DNA. Polymorphisms are useful for genotyping applications in maize. The polymorphic markers are useful to establish marker/trait associations, e.g.... Agent: Thompson Coburn, LLP
20110008795 - Marker for detection of il-17-producing helper t-cell, and method for detection of il-17-producing helper t-cell: Disclosed is a polynucleotide marker or a protein marker for use in the specific detection of an IL-17-producing helper T-cell (a Th17 cell). Also disclosed is a method for detecting a Th17 cell, which is characterized by detecting the occurrence of the polynucleotide marker or the protein marker.... Agent: Sughrue Mion, PLLC
20110008797 - Method and device for the thermal control of temperature-dependent enzymatic reactions using magnetic particles or magnetic beads and alternating magnetic fields: The invention relates to a method for the thermal control of at least one temperature-dependent enzymatic reaction in the presence of magnetic particles, particularly nanoparticles, or magnetic beads in vitro by means of the heating of the magnetic beads or magnetic particles to at least one certain target temperature by... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
20110008771 - Method and materials for triggered release of a biological sample: The invention relates to a method for releasing a biological sample from a solid matrix substantially without disintegration of biomolecules comtained in said biological sample by at least partially transferring the solid state of said matrix into a dissolved or liquid state by changing at least one physico-chemical property of... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC
20110008780 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20110008773 - Method for the determination of data for the preparation of the diagnosis of phakomatosis: The invention concerns a method for the determination of data for the preparation of presymptomatic or prenatal diagnosis of phakomatosis, in particular, a tumor suppressor gene disease, in a high-risk patient, in particular of neurofibromatosis, comprising the steps of: making available the tumor material from a person afflicted with the... Agent: Fitch Even Tabin & Flannery
20110008778 - Method of generating p° cells: Described is a method of the generation of ρ° cells using a mitochondrial targeted restriction endonuclease. This method comprises (a) tranfecting cells with an expression vector containing a gene encoding a fusion protein comprising a mitochondrial targeting sequence (MTS) and a restriction endonuclease operatively linked to a suitable promoter, (b)... Agent: Crowell & Moring LLP Intellectual Property Group
20110008779 - Method of profiling gene expression in a subject having disease: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20110008784 - Methods and compositions for identifying undifferentiated stem cells and assessing cell health: Disclosed herein are methods and compositions for the identification of teloRNA marks to assess the differentiation status of an individual stem cell or a population of stem cells, to diagnose whether and to what extent a stem cell or stem cell culture has already initiated cell differentiation, and to monitor... Agent: Clark & Elbing LLP
20110008789 - Methods and materials for treating inflammatory conditions: Methods and kits for treating inflammatory conditions are described that include modulating kallikrein 6 protease activity.... Agent: Fish & Richardson P.C. (tc)
20110008785 - Methods for forensic dna quantitation: Described herein are methods and devices for nucleic acid quantification and, in particular, to microfluidic methods and devices for nucleic acid quantification. In certain embodiments methods of quantifying a target nucleic acid without the need for amplification are provided. The methods involve, in some embodiments, allowing a binding agent to... Agent: Wolf Greenfield & Sacks, P.C.
20110008786 - Methods of detecting and controlling mucoid pseudomonas biofilm production: Compositions and methods for detecting and controlling the conversion to mucoidy in Pseudomonas aeruginosa are disclosed. The present invention provides for detecting the switch from nonmucoid to mucoid state of P. aeruginosa by measuring mucE expression or MucE protein levels. The interaction between MucE and AlgW controls the switch to... Agent: Stites & Harbison, PLLC
20110008791 - Molecular diagnosis of bacteremia: A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can... Agent: Banner & Witcoff, Ltd.
20110008777 - Pd-1 modulation and uses thereof: Reagents, kits, methods and uses thereof useful for the modulation of immune function, such as the identification of modulators of PD-1 activity, are described. Such reagents, kits, methods and uses thereof may be useful, for example, in the diagnosis, prognostication, prevention and/or treatment of immune-related diseases and/or conditions.... Agent: Klarquist Sparkman, LLP
20110008772 - Probes for detecting mycobacterium tuberculosis and mycobacterium tuberculosis complex and method using the same: The present invention relates to a probe for detecting Mycobacterium tuberculosis complex (MTBC) and Mycobacterium tuberculosis (MTB) from clinical specimens. The method mainly comprised two steps: (1) amplifying a target DNA of the clinical specimens through nested PCR; and (2) hybridizing to the target DNA with a gold nanoparticle probe.... Agent: Wpat, PC Intellectual Property Attorneys
20110008792 - Promoters for expression in modified vaccinia virus ankara: The invention concerns promoters, in particular for the expression of genes and/or coding sequences in vaccinia viruses such as Modified vaccinia virus Ankara (MVA). The invention further concerns expression cassettes comprising said promoter, vectors comprising said expression cassettes as well as pharmaceutical compositions and vaccines.... Agent: Law Office Of Salvatore Arrigo
20110008774 - Protein discovery using intracellular ribosome display: The present invention relates to a method of identifying a protein that binds to a target molecule and has intracellular functionality. This method includes providing a construct comprising a deoxyribonucleic acid molecule encoding the protein which binds to the target molecule, with the deoxyribonucleic acid molecule being coupled to a... Agent: Nixon Peabody LLP - Patent Group
20110008775 - Sequencing of nucleic acids: The present invention relates to the field of analysis of nucleic acid sequences. More specifically, the present invention relates to the method and instrument for high throughput parallel DNA sequencing. The present invention also provides method for selection of sequences from analyte samples for enrichment of the target sequences or... Agent: G Kenneth Smith
20110008782 - Site-specific incorporation of redox active amino acids into proteins: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active... Agent: Quine Intellectual Property Law Group, P.C.
20110008798 - Lipid insertion for antigen capture and presentation and use as a sensor platform: It has been found that moieties containing a lipophilic domain, e.g., lipophilic pathogen activated molecular patterns (PAMPs), insert into the lipid bilayer on a cell membrane to facilitate antigen recognition by the innate immune response receptors. This changes the basic understanding of antigen recognition by the innate immune system. A... Agent: Los Alamos National Security, LLC
20110008799 - Phenotypic ratio of serum amyloid in pre- and type 2 diabetes: The present invention is directed to diagnosing, determining, and/or monitoring type 2 diabetes, pre-diabetes, insulin resistance, and their related conditions by detecting levels and modulations of Serum amyloid A protein (SAA), SAA variants and/or the phenotypic ratio of SAA. The present invention is also directed to methods for identifying and... Agent: Zeman-mullen Law Firm PLLC
20110008801 - Methods for measuring cell-cell or cell-matrix adhesive forces and compounds for disrupting adhesive forces in biological systems: The invention provides an atomic force microscope-based bioassay, assisted by thermodynamic characterizations to quickly and accurately screen for compounds that disrupt cell-cell or cell-substrate interactions.... Agent: Burns & Levinson, LLP
20110008802 - Tnfalpha gene expression as a biomarker of sensitivity to antagonists of inhibitor of apoptosis proteins: TNFα gene expression can be used as a biomarker of a cell's sensitivity to antagonists of inhibitor of apoptosis proteins (IAPs). Methods of the invention are useful for screening patients to identify those who could benefit from administration of an IAP antagonist to treat various malignant or benign tumors, benign... Agent: Banner & Witcoff, Ltd.
20110008803 - Assays for non-apoptotic cell death and uses thereof: The invention relates to methods for identifying agents, which induce oxidative cell death in a tumor cell. The invention further relates to methods for identifying tumor cells, which are sensitive to agents that induce oxidative cell death. The invention also relates to methods for identifying subjects who are suffering from... Agent: Bryan Cave LLP
20110008800 - Crystal structure of cmy-10, a beta-lactamase causing antibiotic resistance with extended-substrate spectrum: The present invention related to a method for crystallizing a CMY-10 being a β-lactamase with extended-substrate spectrum, a crystal of CMY-10, and a crystal structure of CMY-10. With utilization of three-dimensional structure of CMY-10 protein provided by the present invention, it is possible to develop novel antibiotics or inhibitors that... Agent: Edwards Angell Palmer & Dodge LLP
20110008804 - Angiopoietin-1 and -2 biomarkers for infectious diseases that compromise endothelial integrity: The invention relates to a method of identifying a subject having, or at risk of developing, an infectious disease state wherein endothelial integrity is compromised comprising: (a) determining a test ANG-1 level in a sample from a subject; and (b) comparing the test ANG-1 level to a control level wherein... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.
20110008808 - Biomarkers: The invention provides binding agents and assays for ghrelin signal peptide. The agents and assays are useful in methods for predicting, diagnosing, assessing or monitoring acute cardiac disorders, glucose handling disorders and diabetes in a subject. Also provided are nucleotides, polypeptides, and kits useful in the methods of the invention.... Agent: Duane Morris LLP - San Diego
20110008807 - Composition related to rapid elisa process: The present invention provides improved and rapid detection methods for an antigen such as a chemical compound, a peptide, a nucleic acid, or a protein released from cells or virus particles in situ. The detection time for an antigen can be dramatically reduced relative to conventional technologies. The technology can... Agent: Eckert Seamans Cherin & Mellott
20110008805 - Markers associate with arteriovascular events and methods of use thereof: Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating... Agent: Marshall, Gerstein & Borun LLP (tethys)
20110008806 - Method and kit for quantifying of allergen-specific human igg subclasses for the control and attendance of specific immunotherapy: A method for quantifying the levels of allergen-specific human IgG antibody subclasses, particularly of IgG1, IgG2, IgG3 or IgG4 subclasses, using a reverse ELISA immunoenzymatic technique. Also provided is a kit comprising microtitration plates for ELISA already sensitized/covered with monoclonal antibodies, for example, anti-Der p 1 or anti-Der p 2,... Agent: The Maxham Firm
20110008810 - Diagnostic method of mucopolysaccharidoses: m
20110008809 - Method and system for enzymatic detection of melamine: Melamine is a common industrial chemical contaminant which should be absent from food and feed supplies due to melamine's toxicity. Provided is a method to assess the presence of melamine in samples prepared from compositions. The method may include using a microbial enzyme called melamine deaminase which hydrolyzes melamine to... Agent: Meyertons, Hood, Kivlin, Kowert & Goetzel, P.C.
20110008811 - Resin assisted capture of cysteine-modified proteins/peptides and determination of presence and location of modification: A resin connected by amide bond to pyridyl sulfide or methylthiosulfonate can be conjugated to a post traditionally modified protein/peptide to allow determination of presence and kind and optionally location of cysteine modification(s).... Agent: Bacon & Thomas, PLLC
20110008812 - Methods and substances for the diagnosis and therapy of sepsis and sepsis-like systemic infections: Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.... Agent: Millen, White, Zelano & Branigan, P.C.
20110008813 - Assay device and method: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample... Agent: Steptoe & Johnson LLP
20110008814 - Enzyme immunoassay using enzyme-labeled antibody: It was able to provide a method for carrying out an enzyme immunoassay such as ELISA or sandwich ELISA, which hardly inhibited by antiseptics and has high reactivity and sensitivity similar or superior to the performance in the case of the use of an antibody labeled using POD derived from... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.
20110008822 - Cassette and method for plant sampling: A method and storage medium (100) for collecting, storing and analysing a plant sample. The storage medium (100) is configured to provide for multiple portions of the sample to be withdrawn from the storage medium (100) by moving a punch through one of a plurality of apertures (120) through the... Agent: Alston & Bird LLP
20110008821 - Labeled molecule for prognosing tumor grade of head and neck cancer and method for the same: The present invention discloses a labeled molecule for prognosing the tumor grade of head and neck cancer and a method for the same, wherein a 78-kDA glucose regulated protein (GRP78) is adopted as a labeled molecule of head and neck cancer. GRP78 is much more overexpressed in head and neck... Agent: Muncy, Geissler, Olds & Lowe, PLLC
20110008815 - Measuring amount of bound and combined nitric oxide in blood: Amount of combined nitric oxide or nitric oxide present as iron nitrosyls in a blood sample is determined by directing a low power electromagnetic radiation beam at a blood sample to liberate nitric oxide gas, dissolving the liberated nitric oxide gas and electrochemically detecting amount of dissolved nitric oxide gas.... Agent: Bacon & Thomas, PLLC
20110008819 - Method of differentiating stem cells: There is provided an improved efficient method for differentiating stem cells into pancreatic endoderm cells and pancreatic hormone expressing and secreting cells which express Pdx-1 and C-peptide. The invention further provides screening methods for detecting factors of interest that will affect the differentiation of the stem cells into pancreatic endoderm... Agent: Dann, Dorfman, Herrell & Skillman
20110008820 - Methods of determining dose of il-31 agonist to treat pulmonary inflammation: Use of IL-31 agonists, including IL-31, are used to treat agonists are used to treat asthma, airway hyper-responsiveness or allergic rhinitis. The method comprise inhibiting, reducing, limiting or minimizing production of proinflammatory cytokines and include administration of the IL-31 agonist during sensitization or challenge resulting in the asthma, airway hyper-responsiveness... Agent: Zymogenetics, Inc. Intellectual Property Department
20110008818 - Microfluidic device adapted for post-centrifugation use with selective sample extraction and methods for its use: The present disclosure relates to microfluidic devices adapted for post-centrifugation use with selective sample extraction, and methods for their use. Certain embodiments make use of a dye-selective sample extraction. Other embodiments make use of a geographically-selective sample extraction. Other embodiments are also disclosed.... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP Sony Corporation
20110008817 - Microfluidic device having a flow channel within a gain medium: The present disclosure relates to microfluidic devices incorporating a gain medium, such as a laser gain medium, and methods for their use. Certain embodiments make use of mirrors integrated into the microfluidic device substrate. Other embodiments are also disclosed.... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP Sony Corporation
20110008816 - System and method of verification of a prepared sample for a flow cytometer: A system and method for a flow cytometer system including a prepared sample fluid with reference beads; an interrogation zone that analyzes the prepared sample fluid; a peristaltic pump system that draws the sample fluid through the interrogation zone; and a processor that monitors a measured volume of sample fluid... Agent: Schox PLC
20110008823 - Toxicity screening methods: The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining organ-specific toxicity and species-specific toxicity of a given compound based on in vitro assays. In addition, the present invention provides methods of... Agent: Dunlap Codding, P.C.
20110008824 - Device and method of bacteria detection: A bacteria measurement device and method are provided, which separate bacteria from a target object and attach the bacteria to an antibody with fluorescein isothiocyanate applied thereto, generate light using a light emitting unit, and excite the fluorescein isothiocyanate, and in which the excited fluorescein isothiocyanate secondarily emits light, and... Agent: Drinker Biddle & Reath LLP Attn: Patent Docket Dept.
20110008825 - System for conducting the identification of bacteria in urine: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical... Agent: The Webb Law Firm, P.C.
20110008827 - Method to produce recombinant mbp8298 and other polypeptides by nucleotide structure optimization: A method for recombinant production of a polypeptide, exemplified by the therapeutic peptide MBP8298, by recombining and optimizing the nucleic acid encoding said polypeptide, expressing said nucleic acid in a microbial host cell, isolating said polypeptide from the host, and releasing embedded polypeptide from fusion partners or peptide concatamers are... Agent: Choobin & Choobin Consultancy L.l.c Barry Choobin
20110008828 - Methods of incorporating amino acid analogs into proteins: The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs.... Agent: Seed Intellectual Property Law Group PLLC
20110008830 - Process for producing bio-gel and a bio-gel: Provided is a process for producing an enzyme-containing bio-gel from an enzyme solution, particularly a commercial α-amylase solution. When allowed to stand in a vessel, enzyme from the enzyme solution collects on the inside surface of the vessel, thus forming a bio-gel. The bio-gel is recovered by removing the enzyme... Agent: Manelii Denison & Selter PLLC
20110008829 - Use of synthetic scaffolds for the production of biosynthetic pathway products: The present invention provides methods of producing a product or product precursor of a biosynthetic pathway in a genetically modified host cell. The present invention also provides genetically modified host cells comprising nucleic acids encoding a scaffold polypeptide and nucleic acids comprising nucleotide sequences encoding two or more enzymes in... Agent: Bozicevic, Field & Francis LLP
20110008836 - Method for producing alpha-santalene: The present invention provides a method of producing α-santalene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). In particular, the method may be carried out in vitro or in vivo to produce α-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also... Agent: Winston & Strawn LLP Patent Department
20110008832 - Methods for stably retaining foreign genes in cells: A method for preparing a protein or peptide encoded by a foreign gene by expressing a foreign gene, which comprises the steps of: preparing a recombinant vector comprising in an expressible state a gene encoding an aminoacyl-tRNA synthetase, in which a desired foreign gene has been inserted in an expressible... Agent: Jacobson Holman PLLC
20110008834 - Polynucleotides encoding antibodies directed against amyloid-beta peptide: Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ... Agent: Pfizer Inc Mary J Hosley
20110008833 - Protein production in plant cells and associated methods and compositions: The present invention relates to methods and compositions for the expression of protein. Embodiments of methods may comprise the cleavage and repair of a nucleotide sequence encoding a highly expressed protein leading to a reduction in the expression of the highly expressed protein.... Agent: Traskbritt, P.C./dow Agrosciences
20110008831 - Scalable fermentation process: This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly, wherein the process is scalable to a commercial production scale and wherein the expression rate of the capsid protein is controlled to obtain improved yield of... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20110008838 - Chimeric varicella zoster virus virus-like particles: The present invention discloses novel chimeric Varicella Zoster Virus (VZV) virus-like particles (VLPs) comprising chimeric VZV glycoproteins. The invention also discloses vaccine formulations of the chimeric VZV-VLPs and methods of inducing an immune response in subjects.... Agent: Cooley LLP Attn: Patent Group
20110008837 - Modifying glycoprotein production in plans: A method for synthesizing a protein of interest with a modified N-glycosylation profile within a plant, a portion of a plant, or a plant cell is provided. The method comprises co-expressing within a plant a nucleotide sequence encoding a first nucleotide sequence encoding a hybrid protein (GNT1-GalT) comprising a CTS... Agent: Quarles & Brady LLP
20110008839 - Expression vectors comprising the mcmv ie2 promoter: The invention relates to an expression vector comprising the promoter of the mCMV-IE2 gene, or a functional expression promoting fragment thereof, and/or an enhancer of the mCMV-IE2 gene, or a functional expression enhancing fragment thereof, wherein the expression vector does not contain any complete gene of the mCMV.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20110008840 - Anti-cd33 antibodies and methods for treatment of acute myeloid leukemia using the same: The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced versions of these antibodies, functional equivalents and improved versions of these antibodies, immunoconjugates and compositions comprising these antibodies, and the uses of same in... Agent: Sughrue Mion/immunogen
20110008841 - Polynucleotides encoding il-17 receptor a antigen binding proteins: The present invention relates to IL-17 receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, and the polynucleotide sequences encoding them, as well as host cells, expression vectors, and methods of making IL-17 receptor A antigen binding proteins.... Agent: Amgen Inc. Law Department
20110008842 - Novel chimeric tnf ligands: The present invention is directed to an isolated polynucleotide sequence encoding a chimeric TNFα, comprising a first nucleotide sequence encoding a domain or subdomain of a tumor necrosis factor ligand other than TNFα, wherein the encoded domain or subdomain replaces a cleavage site of native TNFα, and a second nucleotide... Agent: Dla Piper LLP (us)
20110008843 - Process for obtaining botulinum neurotoxin: Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.... Agent: Allergan, Inc.
20110008844 - Sialyltransferase and dna encoding the same: p
20110008848 - Enzyme: There is provided a polypeptide having thermostable DNA polymerase activity and comprising or consisting of an amino acid sequence with at least 55% identity to Thermodesulfatator indicus DNA polymerase I Large fragment shown in SEQ ID NO: 1 or in SEQ ID NO:32.... Agent: Hunton & Williams LLP Intellectual Property Department
20110008847 - Method of isolating nucleic acids from a biological sample: Method of preparing a biological sample appropriate for use in a subsequent in vitro nucleic acid amplification reaction. The method involves a rapid, transient exposure to alkaline conditions which can be achieved by mixing an alkaline solution with a pH-buffered solution that includes a detergent and the biological sample to... Agent: Gen Probe Incorporated
20110008846 - Modified enzymes and their uses: The invention relates to an active enzyme of bacterial, fungal, viral, or archae origin, wherein the enzyme is coupled, preferably covalently coupled with at least one polymer having a molecular weight between about 500 to about 20,000 daltons selected from the group consisting of polyethylene glycol and polypropylene glycol. The... Agent: Ballard Spahr LLP
20110008845 - Primers for pcr amplification comprising a basic parts within the primer sequences: The present invention relates to primers for PCR amplification comprising abasic parts within the primer sequences and a method for PCR amplification using the same. More precisely, the present invention relates to primers capable of amplifying different templates and having abasic parts complementary to mutated site or polymorphic site of... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20110008849 - Novel lactose phosphorylase enzymes: The present invention relates to novel lactose phosphorylase enzymes and the uses thereof. More specifically, the invention relates to lactose phosphorylase enzymes created by mutation of a cellobiose phosphorylase from Cellulomonas uda. By introducing mutations in this enzyme, the activity can be switched from cellobiose phosphorylase into lactose phosphorylase.... Agent: Traskbritt, P.C.
20110008850 - Process for the conversion of lignocellulosic solutions containing a high proportion of dry material: The invention describes a process for the conversion of aqueous solutions of lignocellulosic solids comprising a solids content of between 1 and 20% of dry material, said process comprising a step a) for compression of said solution so as to separate the liquid phase present in and between the solids... Agent: Millen, White, Zelano & Branigan, P.C.
20110008851 - Carboxylic acid producing member of the pasteurellaceae: The present invention relates to a novel bacterial strain designated DD1, which has the ability to produce organic acids, in particular succinic acid (SA), which was originally isolated from bovine rumen, and is capable of utilizing glycerol as a carbon source; and variant strains derived there from retaining said capability;... Agent: Connolly Bove Lodge & Hutz LLP
20110008852 - Convergent synthesis of renin inhibitors and intermediates useful therein: Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3—6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration... Agent: Nixon & Vanderhye, PC
20110008853 - Manufacture of amides: wherein the microorganism is stored as none actively growing free cells in a storage medium that comprises water. The stored microorganism may be as whole microbial cells, this may be in the form of a cell paste recovered from a fermentation medium; an aqueous suspension of the microbial cells, prepared... Agent: Basf Corporation Patent Department
20110008854 - Process for the generation of algal oil and electricity from human and animal waste, and other hydrocarbon sources: A method for the generation of electricity includes producing a paste from hydrocarbon waste, delivering the paste to a pyrolysis unit, rendering the paste into a gaseous product stream, allowing the stream to flow through a suitable filter device, extracting energy from the stream, producing electricity, converting water to hydrogen... Agent: Emerson, Thomson & Bennett, LLC
20110008855 - Recombinant microorganism capable of producing polylactate or polylactate copolymer from sucrose and method for producing polylactate or polylactate copolymer from sucrose using the same: Provided are a microorganism capable of producing a polylactate (PLA) or PLA copolymer from sucrose and a method of producing the PLA or PLA copolymer from sucrose using the same. A gene of an enzyme converting lactate into lactyl-CoA and a gene of a polyhydroxyalkanoate (PHA) synthase using lactyl-CoA as... Agent: Mckenna Long & Aldridge LLP
20110008856 - Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids: The gene encoding a 4-hydroxybutyryl-Co A transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, including both bacteria and plants. The new pathways provide means for producing 4HB containing... Agent: Pabst Patent Group LLP
20110008857 - Method for producing polyhydroxyalkanoate: A method for producing polyhydroxyalkanoate (PHA), comprising (i) culturing in a culture medium containing a substrate comprising one or more monoaromatic hydrocarbons selected from the group consisting of benzene, toluene, ethylbenzene, ortho-xylene, meta-xylene, para-xylene and styrene, one or more strains of Pseudomonas putida selected from the group consisting of F1,... Agent: Greenlee Sullivan P.C.
20110008858 - Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol: A non-naturally occurring microbial organism has at least one exogenous nucleic acid encoding a MEK pathway enzyme expressed in a sufficient amount to produce MEK. The MEK pathway includes an enzyme selected from an acetoacetyl-CoA dehydrogenase (bifunctional), an acetoacetyl-CoA aldehyde dehydrogenase, a 3-oxobutyraldehyde reductase, a 3-oxobutanol dehydratase, an MEK oxidoreductase,... Agent: Mcdermott, Will & Emery LLP
20110008861 - Engineered co2 fixing microorganisms producing carbon-based products of interest: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the... Agent: Fenwick & West LLP
20110008860 - Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation: Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme... Agent: Cardinal Law Group
20110008859 - Production of ethanol from tree sap: The present invention involves an improvement in the production of ethanol by using tree sap as the source of the feedstock for the ethanol production process.... Agent: Andrew Polczynski
20110008862 - Complementation of the trichoderma reesei secretome limiting microbiological contaminations within the context of industrial processes: The present invention describes the use of a genetically improved Trichoderma reesei strain allowing to limit microbiological contaminations during an industrial process. The genetic strain improvement allows the latter to overexpress an extracellular protein having known antimicrobial properties and compatible with the secretory system of strains of fungi such as... Agent: Millen, White, Zelano & Branigan, P.C.
20110008863 - Methods for producing fermentation products: The invention relates to methods for treating pre-treated lignocellulose-containing material comprising the steps of: a) subjecting a slurry comprising pre-treated lignocellulose-containing material to agitation in the presence of one or more chemicals and/or one or more enzymes; b) subjecting said slurry to liquid-solid separation; c) recycling at least a portion... Agent: Novozymes North America, Inc.
20110008864 - Processes for producing fermentation products: The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or more trehalases are present in the fermentation medium.... Agent: Novozymes North America, Inc.
20110008865 - Integrated waste/heat recycle system: An integrated system and process for the treatment of organic fractions of municipal solid waste is described herein. The system and the process transform solid waste into fuel and energy. The integrated system and process comprise various different processes for pretreatment, sorting/separating, anaerobic digestion and conversion of biomass and gas... Agent: Pauly, Devries Smith & Deffner, L.L.C.
20110008866 - Tangential flow filtration apparatuses, systems, and processes for the separation of compounds: The invention relates to apparatuses, machines, systems and methods for the recovery and purification of proteins, peptides, nucleic acids, biologically produced polymers and other compounds from aqueous fluids. The aqueous fluids can comprise enzyme concentrates and or a fermentation broth with or without cells or other starting material. The fermentation... Agent: Jill A. Jacabson Genencor Division
20110008867 - Compositions and methods for the production of a compound: The invention features compositions and methods that are useful for the production of a compound.... Agent: Edwards Angell Palmer & Dodge LLP
20110008868 - Multizymes: Multizymes (i.e., single polypeptides having at least two independent and separable enzymatic activities) are disclosed for a variety of applications beyond the synthesis of long chain polyunsaturated fatty acids.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20110008869 - Engineered proteases for affinity purification and processing of fusion proteins: The present invention is directed to the identification of a protease prodomain that is capable of binding a corresponding protease with high affinity. The protease prodomain of the present invention is fused to a second protein to form a protease prodomain fusion protein. The presence of a protease prodomain protein... Agent: Intellectual Property / Technology Law
20110008870 - Fungal protease and use thereof: The present invention is related to a fungal serine protease enzyme useful in modification, degradation or removal of proteinaceous material, which enzyme comprises an amino acid sequence of the mature Tr Prb1 enzyme having an amino acid sequence of SEQ ID NO: 10 or a variant thereof having similar activity.... Agent: Dodds & Associates
20110008872 - Immortalized avian cell lines: This invention relates to immortalized avian cells, including those deposited under accession numbers 09070701, 09070702, and 09070703 at the ECACC, and to the use of these cells for the production of viruses. The cells according to the invention are particularly useful for the production of recombinant viral vectors which can... Agent: Buchanan, Ingersoll & Rooney PC
20110008871 - Production of homogeneous cell line highly permissive to porcine circovirus type 2 (pcv2) infection: Continuous cell lines that are highly permissive to infection by porcine circovirus type 2 (“PCV2”) are described. PCV2 is the causal agent of post-weaning multi-systemic wasting syndrome (“PMWS”) in pigs. PMWS has emerged as a major disease that poses a significant threat to the economics of global swine industry. The... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20110008873 - Purified bacteriophage, its preparation and application: A method of preparation of purified bacteriophage with increased antibacterial activity, in which from bacterial lysate of phages is obtained, advantageously in the presence of lysozyme, chelating factor and detergent, in a continuous manner with ultrafiltration on membranes, the phage containing high molecular mass preparation, devoid of bacterial cell wall... Agent: Cooper & Dunham, LLP
20110008874 - Frozen lactic acid bacterial culture of individual pellet: A stable, pellet-frozen lactic acid bacteria (LAB) culture comprises at least one additive compound in a commercial relevant package. The pellet-frozen culture has at least 50 g frozen material and a content of viable bacteria of at least 109 colony forming units per gram of frozen material. The individual pellets... Agent: Foley And Lardner LLP Suite 500
20110008876 - Method for the treatment of ground water and soils using mixtures of seaweed and kelp: The induction of reducing conditions and stimulating anaerobic process through the addition of species of seaweed (Dulse, Nori, Ascophyllum nodosum, and Kelp) to accomplish accelerated dechlorinization of soil and groundwater contaminated with chlorinated solvents and heavy metals.... Agent: Gregory J. Gore
20110008877 - Cornea storage container to optimize cornea health: An apparatus for shipping, storing, and viewing a cornea. The device offers an improvement to cornea health relative to conventional cornea containers.... Agent: Patterson Thuente Christensen Pedersen, P.A.
20110008878 - Target nucleic acid measuring apparatus: The present invention relates to calculation of an initial template amount in a test sample by fitting a theoretical expression to detection intensity of target nucleic acid corresponding to thermal cycle number, wherein the theoretical expression includes an environmental coefficient as an exponent parameter, a parameter of the initial template... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20110008879 - Bio-assay substrate, bio-assay apparatus, and reading apparatus: A bioassay substrate high in integration amount, free in grouping of substances, low in cost, and the like are provided. Specifically, a bioassay substrate includes detection surfaces S on which detection substances can be solidified, the detection surfaces S is provided on a surface of a disk form substrate capable... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20110008880 - Portable analyzer: A portable analyzer A1 includes: hole forming means designed to form a hole 3 for insertion of a specimen sampling implement 6 therein; and analyzing means capable of analyzing a specimen when the sampling implement 6 is inserted into the hole 3, the hole forming means including a first member... Agent: Morgan Lewis & Bockius LLP
20110008881 - Thermal cycling device with selectively openable sample port: A device for thermal cycling a plurality of samples, the device including a chamber for housing a plurality of sample containers, the chamber having a selectively openable port, wherein one or more selected sample containers can be introduced to or withdrawn from the chamber through the port during thermal cycling.... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC
20110008883 - Mammalian cell-based immunoglobulin display libraries: Disclosed are mammalian cell surface display vectors for isolating and/or characterizing immunoglobulins and various uses thereof.... Agent: Townsend And Townsend And Crew, LLP
20110008882 - Specific grp78 expression-inhibition rnai sequence, medicine thereof and method thereof: The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5′-AAGGATGGTTAATGATGCTGAGAA-3′ [SEQ. ID NO: 1] complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process,... Agent: Muncy, Geissler, Olds & Lowe, PLLC
20110008884 - Pathology grossing tool, cassette, and board: A pathology grossing tool and board are provided for the preparation from a gross tissue of a uniformly thin tissue specimen, which is suitable for processing for histology, histochemistry, antibody binding, genetic analysis, or the like. A tissue cassette for receiving the tissue sample, providing a flat-cutting surface along its... Agent: Nixon & Vanderhye, PC
20110008887 - Epha4-positive human adult pancreatic endocrine progenitor cells: The invention relates to the discovery of a selective cell surface marker that permits the selection of a unique subset of pancreatic stem cells having a high propensity to differentiate into insulin-producing cells or into insulin-producing cell aggregates.... Agent: Morrison & Foerster LLP
20110008885 - Linear double-stranded rna molecule interfering with different target genes: A linear double-stranded RNA molecule, which comprises two or more consecutively or convergently linked short interfering RNAs (siRNAs) each reducing the expression of one of different target genes, and a recombinant expression vector comprising double-stranded DNA sequence expressing the linear double-stranded RNA molecule are provided. The linear double-stranded RNA molecule... Agent: Sughrue Mion, PLLC
20110008886 - Methods and materials for isolating isogenic islet cells: Compositions and methods for isolating and purifying islet cells are described. Islets obtained using such compositions and methods can be transplanted into diabetic patients.... Agent: Fish & Richardson P.C. (tc)
20110008888 - Novel genetic approaches to reduce or inhibit tumorgenicity of human embryonic stem cells and derivatives following transplantation: Self-renewable embryonic stem cells (ESCs), derived from the inner cell mass of blastocysts, can propagate indefinitely in culture while maintaining their normal karyotypes and pluripotency to differentiate into all cell types. Therefore, ESCs may provide an unlimited supply of even specialized cells such as brain and heart cells for transplantation... Agent: Edwards Angell Palmer & Dodge LLP
20110008891 - Partial peptide of lacritin: The invention provides a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, which is a particular partial sequence of lacritin, and having an amino acid length of not more than 70 residues. The polypeptide of the invention can promote adhesion between a cell and an extracellular matrix,... Agent: Leydig Voit & Mayer, Ltd
20110008890 - Self-assembly of peptide-amphiphile nanofibers under physiological conditions: Peptide amphiphile compounds, compositions and methods for self-assembly or nanofibrous network formation under neutral or physiological conditions.... Agent: Nanotope, Inc. C/o Intellevate
20110008889 - Serpin drugs for treatment of hiv infection and method of use thereof: The invention includes compositions comprising substantially purified serpin that are useful in methods for the treatment and prevention of HIV, HSV or HCV infection. The invention also includes methods for the treatment and prevention of HIV, HSV or HCV infection comprising contacting a composition of the invention with a human... Agent: Burns & Levinson, LLP
20110008892 - Methods of tissue generation and tissue engineered compositions: Provided are methods and compositions for constructing stable mammalian embryonic epithelial tissues and organs as well as constructing kidney tissue, and treating renal failure. Disclosed are methods of using an active epithelial growth factor having the capability of effectuating induction of growth and morphogenesis is cells.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP
20110008893 - Medium for mammalian somatic cells and additive therefor: Disclosed are a medium for mammalian somatic cells with which mammalian somatic cells can be grown effectively when the mammalian somatic cells are cultured, while reducing the amount of serum to be added to the medium as much as possible or without adding serum thereto, and an additive to constitute... Agent: Birch Stewart Kolasch & Birch
20110008894 - Lyophilized plasmid/dna transfection reagent carrier complex: Disclosed is a novel formulation for the production of a lyophilized plasmid/DNA transfection reagent complex capable of serving as a carrier for additional free plasmids. Upon rehydration, this plasmid/DNA transfection reagent carrier can be used to introduce simultaneously the complexed plasmid and the additional free plasmids into animal cells. This... Agent: Young & Thompson
20110008895 - Methods and materials for the reproducible generation of high producer cell lines for recombinant proteins: The invention lies in the field of production of recombinant gene products in eukaryotic cells. The invention refers to methods and materials for the fast and reproducible generation of production cells lines suitable for large scale production of recombinant gene products. The invention encompasses specific vector systems, genetic engineered host-cells... Agent: Loza & Loza LLP01/06/2011 > 116 patent applications in 59 patent subcategories. recently filed with US Patent Office
20110003275 - System and method for organ evaluation and preservation: A method and system for organ evaluation and preservation for connection to an organ and for recirculation of a perfusion medium there through. The system comprises a first collection device for collection of the perfusion medium perfused through the organ and a second collection device arranged in an outlet conduit... Agent: Brooks Kushman P.C.
20110003276 - Blood separation and concentration system: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.... Agent: Harness Dickey & Pierce (biomet)
20110003277 - Dioxetane-nanoparticle assemblies for energy transfer detection systems, methods of making the assemblies, and methods of using the assemblies in bioassays: Assemblies comprising nanoparticles and chemiluminescent substrates such as dioxetanes are provided. The assemblies can be used in assays to detect the presence and/or amount of a single analyte or multiple analytes in a sample. Methods of making the assemblies are also described.... Agent: Life Technologies Corporation C/o Intellevate
20110003278 - H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance: The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus (“AIV”). The monoclonal antibodies and related binding proteins are useful for the detection of H5 subtypes of AIV, including the pathogenic H5N1 subtypes. Virus may be detected... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20110003280 - Immunoassay apparatus and immunoassay method: The present invention relates to an immunoassay apparatus comprising a measurement unit 2 for measuring a HIV antibody amount and a HIV antigen amount in a specimen and an analysis means 400 for analyzing on HIV infection based on a measurement result which is outputted from the measurement unit 2.... Agent: Sughrue Mion, PLLC
20110003279 - Monitoring devices and processes based on transformation, destruction and conversion of nanostructures: A large number of properties of nanostructures depend on their size, shape and many other parameters. As the size of a nanostructure decreases, there is a rapid change in many properties. When the nanostructure is completely destroyed, those properties essentially disappear. Systems based on changes in properties of nanostructures due... Agent: Barbara V. Maurer
20110003284 - Aberrantly methylated genes in pancreatic cancer: The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant... Agent: Dla Piper LLP (us)
20110003299 - Canola event pv-bngt04(rt73) and compositions and methods for detection thereof: The present invention provides assays for detecting the presence of the PV-BNGT04(RT73) canola event based on the DNA sequence of the recombinant construct inserted into the canola genome and of genomic sequences flanking the insertion site.... Agent: Snr Denton US LLP
20110003288 - Detection of nucleic acids by type-specific hybrid capture method: Target-specific hybrid capture (TSHC) provides a nucleic acid detection method that is not only rapid and sensitive, but also highly specific and capable of discriminating highly homologous nucleic acid sequences. The method produces DNA/RNA hybrids which can be detected by a variety of methods.... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC
20110003281 - Device and method for multiple analyte detection: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid... Agent: Life Technologies Corporation C/o Intellevate
20110003282 - Differential amplification of mutant nucleic acids by pcr in a mixture of nucleic acids: A method for enriching a mutant nucleic acid in a mixture of nucleic acids, wherein the method comprises: (a) providing a nucleic acid mixture comprising a parental nucleic acid and a mutant nucleic acid of the parental nucleic acid; and (b) amplifying the nucleic acids in the nucleic acid mixture... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20110003293 - Fetal aneuploidy detection by sequencing: The present invention provides apparatus and methods for enriching components or cells from a sample and conducting genetic analysis, such as SNP genotyping to provide diagnostic results for fetal disorders or conditions.... Agent: Wilson Sonsini Goodrich & Rosati Artemis Health, Inc.
20110003302 - Fibroblast growth factor-like polypeptides: The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with FGF-like polypeptides.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20110003287 - Human diabetes susceptibility tnfrsf10c gene: The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the TNFRSF10C gene locus in a biological sample of said subject.... Agent: Occhiuti Rohlicek & Tsao, LLP
20110003306 - Identification of antibiotic resistance using labelled antibiotics: Subject of the present invention is a method for detection of an antibiotic resistance in a micro-organism comprising the steps of exposing suspected micro-organism to a labelled (fluorescent) antibiotic and observing the differences between it and a non-resistant micro-organism of the same type.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20110003304 - Method and kit for detection of autoimmune chronic urticaria: Disclosed is a rapid, non-invasive and highly specific and sensitive diagnostic assay for the identification of individuals with autoimmune chronic urticaria, which makes use of CD203c, and in some embodiments, additional proteins, as a marker for the disease. Test kits for diagnosis of an individual suspected of having autoimmune chronic... Agent: Sheridan Ross PC
20110003289 - Method for detection of pre-neoplastic fields as a cancer biomarker in ulcerative colitis: Among other aspects, the present invention provides biomarkers and methods of identifying precancerous fields in a subject in need thereof. Methods of diagnosing and for providing a prognosis for a subject with an increased risk of developing cancer are also provided, along with methods of determining surgical margins for a... Agent: Townsend And Townsend And Crew, LLP
20110003291 - Method for studying v(d)j combinatory diversity: The invention relates to a method for analysing the diversity of the catalogue of T and/or B lymphocytes in an individual, based on the amplification, from a sample, of genomic DNA fragments by PCR multi-n-plexes, with n≧2, carried out with a combination of at least 3 primers defining at least... Agent: Morgan Lewis & Bockius LLP
20110003296 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20110003297 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20110003298 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20110003294 - Method of profiling gene expression in a healthy subject: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20110003295 - Method of profiling gene expression in a subject undergoing a treatment: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20110003305 - Methods and compositions for nucleic acid amplification: Compositions, reaction mixtures, and methods for performing an amplification reaction, including multiplex amplification reaction, wherein the method comprises using one or more amplification oligomer complexes comprising linked first and second amplification oligomer members. In one aspect, the amplification oligomer complex is hybridized to a target nucleic acid, the target nucleic... Agent: Gen Probe Incorporated
20110003292 - Methods and nucleic acids for analyses of cell proliferative disorders: The invention provides methods, nucleic acids and kits for detecting lung carcinoma. The invention discloses genomic (FOXL2, ONECUT1, TFAP2E, EN2-2, EN2-3, SHOX2-2 and BARHL2) sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.... Agent: Davis Wright Tremaine, LLP/seattle
20110003301 - Methods for detecting genetic variations in dna samples: The invention provides methods, compositions and kits for detecting genetic variation in a DNA sample at one or more polymorphic loci of interest. In some embodiments, the invention provides methods, compositions, and kits for determining the nucleotide present at a single nucleotide variant position of interest in a test sample.... Agent: Life Technologies Corporation C/o Intellevate
20110003307 - Methods for producing interfering rna molecules in mammalian cells and therapeutic uses for such molecules: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20110003308 - Nanoparticle-mediated signal amplification: There is described a new class or type of initiators for polymerization as a means of signal enhancement, nanoparticle initiators, and methods for amplifying signal resulting from recognition events, thereby enhancing the detection of those recognition events. Methods include amplification achieved through polymerization using a nanoparticle initiator conjugated recognition element... Agent: Holland & Hart, LLP
20110003309 - Non-competitive internal controls for use in nucleic acid tests: Provided are non-competitive internal controls for use in nucleic acid tests (NATs), which are obtained from the organisms Methanobacterium thermoautrophicum (MET) and Zea mays (Corn). The non-competitive internal controls have utility in DNA and RNA NATs selected from Influenza A, Influenza B, parainfluenza viruses 1 to 4 (PIV-1 to PIV-4),... Agent: Siemens Corporation Intellectual Property Department
20110003290 - Oligonucleotides and uses thereof: A method for determining the number of tandem repeats in a target polynucleotide, the method comprising (a) providing a sample containing the target polynucleotide, wherein one or more of the tandem repeats in the target polynucleotide is in single stranded form, (b) hybridising a labelled probe oligonucleotide to the single... Agent: The Law Office 0f Geoffrey M. Karny
20110003283 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NO. 55 or a combination of at least two of them is... Agent: Fitzpatrick Cella Harper & Scinto
20110003300 - Rapid sterility microassay: The present invention relates to a method for detecting a viable microorganism in a pharmaceutical composition comprising the steps of providing a filterable pharmaceutical composition; filtering the pharmaceutical composition to provide at least three membranes upon which the pharmaceutical composition is deposited, placing the three membranes onto solid culture media... Agent: Novartis Vaccines And Diagnostics Inc.
20110003286 - Reactor plate and reaction processing method: Disclosed herein is a reactor plate which prevents the entry of foreign matter from the outside and the pollution of a surrounding environment. A reactor plate (1) includes a reaction well (5), a reaction well channel connected to the reaction well (5), and reaction well air vent channels (19) and... Agent: Cheng Law Group, PLLC
20110003285 - Separation purification method and microfluidic circuit: A simple and accurate separation purification method for object biomolecules or bio-associated substance through a particulate aggregative reaction is provided. A microfluidic circuit utilizing a particulate aggregate as a detection marker in a nonfluorescence method such as an electrochemical method or surface plasmon resonance is provided. The separation purification method... Agent: Fish & Richardson P.C. (ny)
20110003303 - Sheath flow devices and methods: The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid... Agent: Weaver Austin Villeneuve & Sampson LLP
20110003311 - Diagnosis system for determining the biologically effective parathyroid hormone activity in a sample: Diagnosis system or immunoassay for the determination of the effective parathyroid hormone activity in a sample, and for a diagnosis and treatment of calcium metabolism disturbances, osteopathies and hyper- or hypoparathyroidisms. The parathyroid hormone activity is measured with the aid of an antibody which binds to an epitope in the... Agent: Nelson Mullins Riley & Scarborough LLP Floor 30, Suite 3000
20110003310 - Oral fluid rapid immunochromatography test: The present invention relates to an oral fluid rapid immunochromatography test. More particularly, the present invention relates to an oral fluid collection swab separate from a lateral flow immunochromatography strip for detecting an analyte in oral fluid, consisting essentially of a sample pad, a conjugate pad, a test zone and... Agent: Mcdermott Will & Emery LLP
20110003315 - Chimeric pcsk9 proteins, cells comprising same, and assays using same: A chimera protein comprising in the following order: a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence... Agent: Goudreau Gage Dubuc
20110003320 - Immunoassay method and kit and developing solvent therefor: The above method is to immunologically measure the target substance by using the test piece for immunochromatography which comprises a membrane carrier having a first antibody or a first antigen capable of binding specifically to the target substance immobilized thereon, an insoluble carrier having a second antibody or a second... Agent: Birch Stewart Kolasch & Birch
20110003316 - Luminescence-based methods and probes for measuring cytochrome p450 activity: The present invention provides methods, compositions, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e.g. luciferin or coelenterazines, that are cytochrome P450... Agent: Michael Best & Friedrich LLP
20110003317 - Methods of screening compounds for insect-control activity involving the tyramine receptor: An exemplary method of screening compositions for insect control activity includes, providing an insect cell expressing a receptor of the insect olfactory cascade or fragment thereof, contacting a test composition to the insect cell, measuring at least one parameter selected from olfactory cascade receptor binding affinity, intracellular cAMP levels, and... Agent: Davis Wright Tremaine LLP - San Francisco
20110003318 - Nucleotide and protein sequence of mammastatin and methods of use: A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and... Agent: Casimir Jones, S.c.
20110003319 - Transgenic trasnchromosomal rodents for making human antibodies: The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies.... Agent: Baker Botts L.L.P.
20110003321 - Monitoring of intercellular mitochondorial polarization: Changes in surface plasmon resonance angle resulting from changes in mitochondrial polarized state of the living cells are detected by use of a surface plasmon resonance device. Alternatively, one or plural agents are administered to the living cells, and changes in surface plasmon resonance angle resulting from changes in mitochondrial... Agent: Birch Stewart Kolasch & Birch
20110003312 - Linked peptide fluorogenic biosensors: Biosensors, compositions comprising biosensors, methods of producing biosensors, and methods of using biosensors are disclosed. The biosensors comprise a fluorogen-activating peptide and a blocking peptide. The fluorogen-activating peptide and blocking peptide are covalently linked through a peptide linker. The blocking peptide associates with the fluorogen-activating peptide thereby blocking an active... Agent: K&l Gates LLP
20110003313 - Amplified labeled conjugate for use in immunoassays: A conjugate, for use as a detection reagent in an immunoassay, is based on a hydrophilic monodisperse macromolecule, i.e. a macromolecule having a substantially uniform size and shape, the macromolecule forming a practically useful and manageable carrier, to which carrier at least one binding entity and at least one label... Agent: Hiscock & Barclay, LLP
20110003314 - Hapten, immunogens and derivatives of ascomycin useful for preparation of antibodies and immunoassays: The invention teaches derivatives of ascomycin and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of tacrolimus in patient specimens. Antibodies produced from the disclosed immunogens capable of binding to tacrolimus with cross-reactivity of no more than 5% with each of 15-O-demethyl tacrolimus, 31-O-demethyl... Agent: Andrus, Sceales, Starke & Sawall, LLP
20110003322 - Cell-enzyme based biosensors: The invention relates to a sensor (1) comprising a sensing layer (2) and a surface layer (3), wherein said surface layer comprises, a first region (4) suitable for adherent growth of cells (6), and a second region (5), adjacent to said second layer, suitable for the attachment of proteins, wherein... Agent: Knobbe Martens Olson & Bear LLP
20110003323 - Bioreactor systems and associated methods of processing bioreactor vessels: A bioreactor processing unit (10) includes at least one cell culture module (200) comprising: a base (202) including a receiving station (204) for removably receiving a plurality of bioreactor vessels (400) at respective locations (206); and a clamp plate (240). The clamp plate (240) is removably connectable to the base... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.
20110003327 - Methods for production of atrial progenitors and their differentiation into smooth muscle cells and cardiomyocytes: The present invention generally relates to methods to identify and isolate atrial progenitors, and in some embodiments to the atrial progenitors are positive for both Islet 1 (Isl1) and sarcolipin (SLN). One aspect of the present invention relates to methods to differentiate progenitors into Isl1+/SLN+ atrial progenitors. Another aspect of... Agent: David S. Resnick
20110003325 - Microfluidic device: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices have onboard sterilization capabilities. In other embodiments, microfluidic devices have integral collection bags and methods for keeping the microfluidic channels clean.... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP Sony Corporation
20110003324 - Microfluidic device having onboard tissue or cell sample handling capability: The present disclosure is generally directed to systems for the storage and preservation of an original tissue or cell sample onboard a microfluidic device, such as a cytometry chip. In some embodiments, the sample may be disassociated while onboard the microfluidic device.... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP Sony Corporation
20110003326 - Microinjection apparatus and method: The present invention discloses a microinjection apparatus (100) for microinjection of substances into individual substances comprising at least one carrier (120, 130) on which at least one sample is immobilizable. In embodiments, the apparatus comprises at drivable support (110) on which at least one carrier is positioned, wherein the support... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP
20110003329 - Method for neutralization of antibiotics in a culture medium: The present invention is directed to a method and means for the neutralization, binding, and/or inactivation of antimicrobials in a test sample. The invention is also directed to a method of detecting the presence of one or more microorganisms in a test sample by culturing the test sample in a... Agent: Biomerieux Vitek Inc.
20110003330 - Microfluidic device: The present disclosure relates to microfluidic devices adapted for facilitating cytometry analysis of particles flowing therethrough. In certain embodiments, the microfluidic devices have onboard data storage capabilities. In certain other embodiments, the microfluidic devices have onboard anticoagulants. In certain other embodiments, the microfluidic devices have onboard test and control channels.... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP Sony Corporation
20110003328 - System for detecting microbial contamination: The present invention relates to a system for detecting microbial contamination of a liquid specimen comprising a device for concentrating micro-organisms from a liquid specimen, having (i) a hypobaric chamber, (ii) a filter housing comprising a liquid-permeable bed of an adsorbent material and adapted for being fluidly connected to said... Agent: Hoffmann & Baron, LLP
20110003331 - Method for enhanced production of biofuels and other chemicals using biological organisms: The invention of this disclosure, also known as the method of this disclosure, provides the means of improved Chemical Product production from chemical production systems that use biological organisms to produce the desired chemicals. This improved production is by means of subjecting chemical producing organisms to vibration waves or to... Agent: Thomas Clayton Pavia
20110003332 - Recombinantly modified plasmin: Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the native... Agent: Womble Carlyle Sandridge & Rice, PLLC
20110003333 - Method for increasing expression yield of a protein of interest: The present invention relates to a method of producing a protein of interest comprising: (a) cultivating a mutant cell under conditions conducive for production of the protein wherein the mutant has a reduced or no expression of an endogenous polypeptide shown in SEQ ID NO: 2 compared to a parent... Agent: Novozymes North America, Inc.
20110003338 - Antibodies with enhanced adcc function: The present invention concerns antibodies enhanced antibody-dependent cell mediated cytotoxicity (ADCC) and method for preparation thereof.... Agent: Arnold & Porter LLP (24126) Attn: Sv Docketing Dept.
20110003337 - Immunoglobulin compositions and methods of producing same: e
20110003334 - Method for producing a cell capable of high-yield production of heteroproteins: The present invention relates to a method for producing a cell capable of high-yield production of a desired polypeptide, wherein a strongly taurine transporter-expressing cell into which DNA encoding the desired polypeptide has been introduced is cultured in the presence of a high concentration of methotrexate and a cell capable... Agent: Foley And Lardner LLP Suite 500
20110003336 - Methods for increasing the therapeutic efficacy of immunoglobulin g class 3 (igg3) antibodies: The present invention relates to methods for increasing the therapeutic efficacy of immunoglobulin G class 3 (IgG3) antibodies, immunoglobulin G class 3 (IgG3) antibodies with an improved therapeutic efficacy and the use thereof as a medicament, in particularly a medicament for immunotherapy. Specifically, the present invention relates to methods for... Agent: Bozicevic, Field & Francis LLP
20110003335 - Methods for prognosing the status of tumor patients: A method for prognosing the status of a tumor patient is provided, wherein the level of antibodies against Saccharomyces cerevisiae, Candida sp., especially Candida albicans, Aspergillus fumigatus or Klebsiella pneumoniae is determined in said the patient, and prognosing the status of the patient upon the level of these antibodies determined... Agent: Collard & Roe, P.C.
20110003339 - Pathogenic escherichia coli associated protein: The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli, such as the enteropathogenic (SPEC) and enterohemorrhagic (EHEC) E. coli. The invention also provides isolated nucleic acid sequences encoding EspA polypeptide, EspA peptides, a recombinant method for producing recombinant EspA, antibodies which bind to EspA,... Agent: Fenwick & West LLP
20110003340 - Synthetic genes for plant gums and other hydroxyproline-rich proteins: A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline (Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum... Agent: Dinsmore & Shohl LLP
20110003341 - Process for producing saccharide: A process for producing saccharide, including saccharifying decrystallized cellulose prepared from a raw material containing cellulose having cellulose I-type crystallinity of more than 33%, the process including: treating the cellulose-containing raw material by means of a mill to reduce the cellulose I-type crystallinity of the cellulose to 33% or less,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110003342 - Inosine producing microorganism belonging to the genus corynebacterium and process of producing inosine using the same: A microorganism of the genus Corynebacterium having the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the... Agent: Cantor Colburn LLP
20110003343 - Conjugates of biomolecules to nanoparticles: Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological applications. For example, provided herein are polymerase-nanoparticle conjugates including a polymerase linked to a nanoparticle, wherein the conjugate has polymerase activity. Such conjugates can exhibit reduced... Agent: Life Technologies Corporation C/o Intellevate
20110003344 - Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol: The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2... Agent: Mcdermott, Will & Emery LLP
20110003345 - Production and secretion of glucose in photosynthetic prokaryotes (cyanobacteria): The present invention includes compositions and methods for making and using an isolated cyanobacterium that includes a portion of an exogenous bacterial cellulose operon sufficient to express bacterial cellulose, whereby the cyanobacterium produces extracellular glucose. The compositions and methods of the present invention may be used as a new global... Agent: Chalker Flores, LLP
20110003347 - Method for producing a target substance by fermentation: A method is described for producing a target substance utilizing a microorganism by culturing the microorganism in a medium to produce and accumulate the target substance in the medium, and then collecting the target substance from culture. The microorganism is imparted with isomaltase activity, or modified to increase isomaltase activity.... Agent: Cermak Nakajima LLP Acs LLC
20110003348 - Organic material production system using biomass material and method: An organic material production system includes: a pretreatment device (12) that pulverizes a biomass material (11); a hydrothermal decomposition apparatus (14) that hydrothermally decomposes a pulverized biomass (13) by causing it to countercurrently contact with hot compressed water (15), elutes lignin components and hemicellulose components into the hot compressed water... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20110003346 - Synthesis method of aromatic amino acids: A synthesis method of aromatic amino acids according to one aspect of the present invention includes a process of preparing thermostable enzyme, a process of amino-transferring reaction and a process of product precipitation and enzyme recycling. The process of preparing thermostable enzyme comprises an isolation step of the gene of... Agent: Muncy, Geissler, Olds & Lowe, PLLC
20110003349 - L-threonine overproducing microorganism and method for preparing l-threonine using the same: The present invention relates to a mutant microorganism producing a high concentration of L-threonine in high yield, prepared using site-specific mutation, not random mutation, such as treatment with a mutation inducer, a method for preparing the same, and a method for preparing L-threonine using the mutant microorganism producing L-threonine. By... Agent: Licata & Tyrrell P.C.
20110003351 - Delta-5 desaturase and uses thereof: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e., “Δ6-desaturase”) and to uses thereof. In particular, Δ5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid... Agent: Ross Products Division Of Abbott Laboratories Department 108140-ds/1
20110003350 - System and method for high-voltage pulse assisted aggregation of algae: A method and device for aggregating algae in an aqueous solution is disclosed. The method can include providing an algae feed comprising a liquid and algae dispersed therein. The algae feed can be aggregated by applying a nanosecond pulsed electric field to the algae feed. The nanosecond pulsed electric field... Agent: Gregory A. Nelson Novak Druce & Quigg LLP
20110003352 - process for the stepwise treatment of lignocellulosic material to produce reactive chemical feedstocks: A method for the fractionation of lignocellulosic materials into reactive chemical feedstock in a batch or semi continuous process by the stepwise treatment with aqueous aliphatic alcohols in the presence of sulfur dioxide or acid. Lignocellulosic material is fractionated in a fashion that cellulose is removed as pulp, or converted... Agent: Altera Law Group, LLC
20110003353 - Multimeric oxidoreductases: The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.... Agent: Danisco US Inc. Attention: Legal Department
20110003354 - Method for converting herbaceous plant fibers into fuel alcohol: This disclosure teaches a method of converting herbaceous plant fibers into fuel alcohol comprising the following steps: The pre-treatment stage consists of grinding; using ultrasonic waves; adding the liquids mixed with alcohol, liquid ammonia, and water; adding NaOH; and then stirring and cooking. The second stage involves the recovery of... Agent: Kaikwai Chan
20110003356 - Process for production of xylitol: The invention provides a process for producing xylitol from xylose by a yeast strain capable of converting the xylose to xylitol comprising independently growing the yeast strain in a medium; transferring the yeast strain from the medium to a feed solution, the feed solution comprising of xylose in water, and... Agent: Townsend And Townsend And Crew, LLP
20110003355 - Process of separating components of a fermentation broth: A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in... Agent: Mcdermott, Will & Emery LLP
20110003357 - Conversion of algae to liquid methane, and associated systems and methods: Systems and methods for converting algae to liquid methane are disclosed. The system in accordance with a particular embodiment includes an algae cultivator, an anaerobic digester operatively coupled to the algae cultivator to receive algae and produce biogas, and a biogas converter coupled to the anaerobic digester to receive the... Agent: Perkins Coie LLP Patent-sea
20110003359 - Biodevice: Disclosed is a biodevice which has a porous membrane (8) and flow paths (10) and (12) formed therein. In a preferred embodiment, the flow path (10) and the flow path (12) are opposed to each other with the porous membrane (8) being interposed between them. The flow path (10) serves... Agent: Cheng Law Group, PLLC
20110003358 - Cultures of gfap+ nestin+ cells that differentiate to neurons: Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in adherent or suspension cultures.... Agent: Clark & Elbing LLP
20110003360 - Delta-6 desaturase and uses thereof: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e., “Δ6-desaturase”) and to uses thereof. In particular, Δ5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid... Agent: Ross Products Division Of Abbott Laboratories Department 108140-ds/1
20110003361 - Novel fructosyl peptide oxidase: A novel fructosyl peptide oxidase having physicochemical properties useful as an enzyme for clinical diagnosis, and a method for producing a novel fructosyl peptide oxidase are provided herein, the method comprising: culturing a microorganism capable of producing the oxidase in a medium; and collecting the oxidase from the culture. Furthermore,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20110003362 - Conjugates of biological substances: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.... Agent: Mckinney Law Group, Apc
20110003363 - Reduction of dimer content in factor vii polypeptide compositions by heat treatment: The present application relates to a method of reducing the content of dimers in Factor VII polypeptide composition by heat treatment.... Agent: Novo Nordisk, Inc. Intellectual Property Department
20110003364 - Subtilases: The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase.... Agent: Novozymes North America, Inc.
20110003365 - Method of preparing induced pluripotent stem cells deprived of reprogramming gene: Provided is a method of preparing an induced pluripotent stem cell (iPS cell) deprived of a reprogramming gene, including providing an iPS cell having an expression vector wherein a loxP sequence is placed on each of the 5′ and 3′ sides of the reprogramming gene or a vector component necessary... Agent: Leydig Voit & Mayer, Ltd
20110003366 - Methods of using pneumatic bioreactors: A pneumatic bioreactor includes a vessel containing a fluid to be mixed and at least one mixing device driven by gas pressure. A first embodiment includes a floating impeller that rises and falls in the fluid as gas bubbles carry it upward to the surface where the gas is then... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20110003367 - Material for capturing microbes, device for capturing microbes, method of capturing microbes, and method of producing material for capturing microbes: The invention relates to a material for capturing microbes or the like, a device for capturing microbes or the like, a method of capturing microbes or the like, and a method of producing a material for capturing microbes or the like, and has an object of using a pulverizable resin... Agent: Haynes And Boone, LLPIPSection
20110003368 - Thixotropic gel for vadose zone remediation: A thixotropic gel suitable for use in subsurface bioremediation is provided along with a process of using the gel. The thixotropic gel provides a non-migrating injectable substrate that can provide below ground barrier properties. In addition, the gel components provide for a favorable environment in which certain contaminants are preferentially... Agent: J. Bennett Mullinax J. Bennett Mullinax, LLC
20110003369 - Method for the deparaffinisation of biological specimens: t
20110003370 - Process to remove impurities from triacylglycerol oil: The present invention is directed to a process to remove impurities from triacylglycerol oil including mixing the oil and a fluidic agent, pumping the mixture through a flow-through hydrodynamic cavitation apparatus at a pre-determined inlet pump pressure, creating hydrodynamic cavitation in the mixture, maintaining the hydrodynamic cavitation for a pre-determined... Agent: Kelly Lowry & Kelley, LLP
20110003371 - Diagnostic devices: The present invention relates to analytical methods, platforms, and devices for the rapid and efficient immunochromatic determination of one or more components in fluid samples. The devices are especially useful for identifying analytes in small volumes of whole blood samples utilizing one membrane principally for separating particles such as red... Agent: Sim & Mcburney
20110003372 - Microfluidic gradient devices: Provided herein are apparatuses, systems and methods for the efficient generation of gradients.... Agent: Davis Wright Tremaine LLP/los Angeles
20110003373 - Analyte treatment apparatus: The analyte treatment apparatus is a tissue fragment treatment apparatus that successively supplies a variety of liquid chemicals individually stored in a plurality of liquid chemical tanks 24 made of resin to a treatment tank, in which a tissue fragment has been inserted as an analyte collected from an organism,... Agent: Blakely Sokoloff Taylor & Zafman LLP
20110003374 - Bioreactor: A bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) in the interior (9) of the container (2), and a drive (4) arranged outside the container (2) and connectable to the shaft... Agent: Hespos & Porco LLP
20110003375 - flow reactor: A reaction system and a reactor which comprises of two or more reaction cells wherein said cells are separated by inter cell conduits and having a means of causing agitation within the cells which does not require a mechanical connection of the agitating mechanism within the cell to a drive... Agent: Dobrusin & Thennisch PC
20110003376 - Cell culture dish: A cell culture dish, comprising: a dish with a bottom wall and a circumferential side wall standing upward from the same, a lid, which sits sealingly on the side wall in an aeration position, and means for holding the lid on the dish above the sealing position in an aeration... Agent: Vidas, Arrett & Steinkraus, P.A.
20110003377 - Specimen processing apparatus and speciment processing method: According to an example of the invention, a specimen processing apparatus which distributes specimen containers capable of containing a specimen each to a plurality of outlet ports, includes, a plurality of inlet ports, the outlet ports disposed downstream relative to the inlet ports, a plurality of main transport paths which... Agent: Nixon & Vanderhye, PC
20110003379 - Chimeric autoprocessing polypeptides and uses thereof: A chimeric polypeptide comprising an autoprocessing segment having an amino acid sequence being capable of auto-cleavage, a polynucleotide encoding such a polypeptide, and uses of such a polypeptide and such a polynucleotide are provided. a polynucleotide are provided.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20110003378 - Multiple promoter expression cassettes for simultaneous delivery of rnai agents: The present invention provides multiple-promoter expression cassettes for simultaneous delivery of RNAi, preferably to mammalian cells in vivo.... Agent: Patton Boggs LLP
20110003380 - Sample processing system and methods: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so... Agent: Townsend And Townsend And Crew, LLP
20110003381 - Viral vectors and host cells and methods of making and using them: The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating, selectively packaging, and using such a vector, isolated molecules of specified nucleotide and amino acid sequences relevant to such vectors, a pharmaceutical composition and a host cell comprising such a vector, and methods of using such... Agent: Virxsys C/o Mofo Sd
20110003382 - Use of corticosterone for increasing egg antibody: Methods for increasing antigen-specific egg yolk antibody titer and eggs having increased antigen-specific egg yolk antibody titer are disclosed. More specifically, the method for increasing antibody titer may include the steps of: administering to an egg-laying animal a corticosteroid; and then, exposing the animal to an immunogenic dose of the... Agent: Patent Docket Department Armstrong Teasdale LLP
20110003383 - Antibodies to ht5gj57: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing... Agent: Human Genome Sciences Inc. Intellectual Property Dept.
20110003384 - Compositions and methods of use for mgd-csf in disease treatment: Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are... Agent: Fiveprime/finnegan
20110003386 - Identification and characterization of cancer stem cells and methods of use: A subpopulation of cancer stem cells expressing elevated levels of uPAR have been identified among a population of cancer cells. Methods are provided for treating proliferative disorders such as cancer by administering one or more uPAR inhibitors. Methods are likewise provided for predicting the likelihood of recurrence of a cancer,... Agent: Perkins Coie LLP
20110003387 - Method of producing erythrocytes without feeder cells: Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes. Further provided herein is a bioreactor... Agent: Jones Day
20110003388 - Methods of making enhanced, autologous fat grafts: Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are... Agent: Knobbe Martens Olson & Bear LLP
20110003389 - Cell culture instrument and cell culture method using the same: Provided is a cell culture instrument which has excellent operability while including a plurality of wells capable of holding cells. The cell culture instrument according to the present invention includes a base portion in which a well group including a plurality of first wells capable of holding cells is formed,... Agent: Oliff & Berridge, PLC
20110003390 - Method and device for cell culture in open continuous mode: The present invention relates to the use of cell cultures in the open continuous mode, to a method for selecting static cell variants or cell variants which proliferate in suspension, to a culture substrate and to a device suitable for implementing this method.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, NwPrevious industry: Education and demonstration
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