Chemistry: molecular biology and microbiology patents - Monitor Patents
FreshPatents.com Logo    FreshPatents.com icons
Monitor Keywords Patent Organizer File a Provisional Patent Browse Inventors Browse Industry Browse Agents



USPTO Class 435  |  Browse by Industry: Previous - Next | All     monitor keywords
12/2010 | Recent  |  14: Jul | Jun | May | Apr | Mar | Feb | Jan | 13: Dec | Nov | Oct | Sep | Aug | Jul | Jun | May | Apr | Mar | Feb | Jan | 12: Dec | Nov | Oct | Sep | Aug | July | June | May | April | Mar | Feb | Jan | 11: Dec | Nov | Oct | Sep | Aug | Jul | Jun | May | Apr | Mar | Feb | Jan | 10: Dec | Nov | Oct | Sep | Aug | Jul | Jun | May | Apr | Mar | Feb | Jan |  | 09: Dec | Nov | Oct | Sep | Aug | Jl | Jn | May | Apr | Mar | Fb | Jn |  | 2008 | 2007 |

Chemistry: molecular biology and microbiology December patent applications/inventions, industry category 12/10

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
12/30/2010 > patent applications in patent subcategories. patent applications/inventions, industry category

20100330547 - Perfusing an organ with an in situ generated gas: Method and system for organ preservation. According to one aspect, an organ may be preserved by being perfused with an in situ generated preserving gas. The organ may be, for example, a human or porcine pancreas, and perfusion of the pancreas may be anterograde, retrograde, ductal, anterograde/ductal, or retrograde/ductal. The... Agent: Kriegsman & Kriegsman

20100330550 - Detection of human papillomavirus: The present invention relates to in vitro methods of screening human subjects for the presence of human papillomavirus (HPV) which exhibits loss of regulation of E6/E7 mRNA expression and loss of replication and/or expression of a stabilized pre-mRNA encoding full length E6 protein. In particular, the invention provides in vitro... Agent: Wolf Greenfield & Sacks, P.C.

20100330549 - Heteroduplex tracking assay: A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations... Agent: Frommer Lawrence & Haug

20100330548 - Nucleic acid primers and probes for detecting human and avian influenza viruses: Provided are nucleic acid sequences that are used to prepare primers and probes that are used in a kinetic polymerase chain reaction (kPCR) assay to detect influenza viruses in a human or animal subject. The starting material for the kPCR assays may be DNA or RNA and the assays may... Agent: Siemens Corporation Intellectual Property Department

20100330555 - Accuracy fluorescence in-situ hybridization assay of samples with apoptotic cells: The present application discloses a process for improving the accuracy of fluorescence in-situ hybridization (FISH) assays in which the sample being assayed is likely to contain cells in apoptosis by excluding these cells from the evaluation of the FISH assay. This is conveniently done by labeling the cells in apoptosis... Agent: General Electric Company Global Research

20100330568 - Assay and method for the assessment of responders and non-responders to nk cell modulation by immunoglobulin therapy: A method of determining a patient's susceptibility for NK cell modulation by immunoglobulins in response to a treatment of a disease or prophylaxis of a disease with immunoglobulins wherein a modulation of natural killer cells caused by said immunoglobulins is determined.... Agent: Jacobson Holman PLLC

20100330553 - Chemically induced optical signals and dna sequencing: Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a... Agent: Intel Corporation C/o Cpa Global

20100330574 - Chimeric primers with hairpin conformations and methods of using same: Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5′ of the target-specific primer sequence; a tag sequence 5′ of the anti-tag sequence; and a blocker between the anti-tag sequence and... Agent: Fulbright & Jaworski L.L.P.

20100330579 - Detection of pcr products in gel electrophoresis: Disclosed is a method for analyzing nucleic acids in a sample comprising the following steps: (i) adding a DNA binding dye containing a benzothiazolium or benzoxazolium group to the sample to be analyzed, (ii) carrying out a polymerase chain reaction, (iii) applying the sample to a gel matrix, (iv) separating... Agent: Roche Diagnostics Operations Inc.

20100330554 - Diagnostic kit for solid cancer and medicament for solid cancer therapy: The present invention provides novel solid cancer antigenic proteins, and diagnostic kits for solid cancer and therapeutic agents for solid cancer based on the antigenic proteins. Specifically, the present invention provides a human solid cancer antigenic polypeptide having an amino acid sequence selected from the group consisting of SEQ ID... Agent: Birch Stewart Kolasch & Birch

20100330567 - Dna markers for management of cancer: A method is provided for assessing allelic losses and hypermethylation of genes in CpG tumor promotor region on specific chromosomal regions in cancer patients, including melanoma, neuroblastoma breast, colorectal, and prostate cancer patients. The method relies on the evidence that free DNA and hypermethylation of genes in CpG tumor promotor... Agent: Perkins Coie LLP

20100330559 - Forensic identification: The invention provides allelic ladder mixtures and individual alleles suitable for use in such mixtures. The allelic ladder mixtures give improved identification and distinguishing capabilities, particularly suitable in forensic investigations.... Agent: Workman Nydegger 1000 Eagle Gate Tower

20100330558 - Gene expression profiling for identification, monitoring and treatment of cervical cancer: A method is provided in various embodiments for determining a profile data set for a subject with cervical cancer or conditions related to cervical cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100330566 - Genetic polymorphisms in the prostate-specific antigen gene promoter: The present invention includes methods of identifying a subject at risk for increased cellular PSA production and/or prostate cancer by detecting the presence or absence of a genetic polymorphism in the prostate specific antigen gene.... Agent: Myers Bigel Sibley & Sajovec

20100330556 - Genome analysis using a nicking endonuclease: A method of genome analysis is provided. In certain embodiments, the method of comprises: a) contacting a genomic sample comprising a double-stranded DNA with a site-specific nicking endonuclease to provide a nicked double-stranded DNA comprising a plurality of nick sites, in which the nicking endonuclease nicks a site adjacent to... Agent: Agilent Technologies, Inc. In Care Of: Cpa Global

20100330557 - Genomic coordinate system: A method of sample analysis is provided. In certain embodiments, the method comprises: a) site-specifically labeling a test genome with at least two different labels to produce a labeled genome labeled at a plurality of discrete sites across the genome; b) stretching a nucleic acid of the labeled genome to... Agent: Agilent Technologies, Inc. In Care Of: Cpa Global

20100330569 - Hydroxymethyl linkers for labeling nucleotides: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that... Agent: Medlen & Carroll, LLP

20100330560 - Immunogenic polypeptide isolated from mycobacterium avium subspecies paratuberculosis and uses thereof: The present invention relates to an immunogenic polypeptide isolated from Mycobacterium avium subspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in vaccines against Johne's disease and in methods for detection of the disease. Antibodies against the polypeptide or variants may be used in diagnostic... Agent: Jacobson Holman PLLC

20100330561 - Marker gene for detection of tumor promoter, and method for detection of tumor promoter: The present invention provides 27 marker genes comprising Orm1, Scarb1, Stmn1, Rad21, Nup54, Jun, Dmp1, Abi1, 6530403A03Rik, Slc2a1, Plf (Plf2, Mrpplf3), Fosl1, Chek1, Pik3r5, JunB, Vegfa, Rif1 (LOC671598), Il1rl1, Phex, Tfrc, Zfhx1b, Rad51ap1, Hells, Mcm3, Orm2, Car13 and Ccnb1, which enables the detection of a tumor promoter in a simple... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100330563 - Medicinal agent for disease associated with epstein-barr virus, and method for screening of the medicinal agent: 1-(2-Fluoro-4-thio-β-D-arabinofuranosyl)-5-methyluracil exhibits an anti-EB virus activity, and is therefore effective as a prophylactic or therapeutic agent for a disease associated with an EB virus. Each of a plasmid capable of expressing EB virus-TK and a plasmid capable of expressing human-TK is introduced into a TK-defect cell, thereby producing two types... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100330581 - Method for in vitro diagnosis or prognosis of testicular cancer: The invention relates to a method for in vitro diagnosis or prognosis of testicular cancer which comprises a step of detecting the presence or absence of at least one expression product from at least one nucleic acid sequence selected from the sequences identified in SEQ ID NOS: 1 to 6... Agent: Oliff & Berridge, PLC

20100330580 - Method for the in vitro diagnosis or prognosis of testicular cancer: A method for in vitro diagnosis or prognosis of testicular cancer in a biological sample from a patient suspected of suffering from testicular cancer, having a step of detecting the presence or absence of methylation of CpG dinucleotides in at least one genomic DNA target sequence of the sample, the... Agent: Oliff & Berridge, PLC

20100330571 - Method of measuring adaptive immunity: A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta... Agent: Woodcock Washburn LLP

20100330576 - Method, kits, and reaction mixtures for high resolution melt genotyping: Various methods are described that provide for high resolution melt (HRM) genotyping. Some embodiments comprise providing a locus specific primer, and two allele specific primers each comprising at least one single nucleotide polymorphism (SNP) allele-hybridizable sequence, wherein at least one of the allele specific primers also comprises at least one... Agent: Life Technologies Corporation C/o Intellevate

20100330577 - Methods for identification of an antibody or a target: This disclosure relates to methods for identifying an antibody, a target molecule, or an agent by analyzing the immunoglobulin repertoire sequence data in a sample and by determining the most dominant VH and VL chains present in said sample, as well as materials used therewith.... Agent: Morphosys Ag

20100330575 - Molecular diagnostics reagents and methods: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostics testing.... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20100330551 - Novel restriction endonucleases, dna encoding these endonucleases and methods for identifying new endonucleases with the same or varied specificity: Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases... Agent: Harriet M. Strimpel, D. Phil.

20100330552 - Novel restriction endonucleases, dna encoding these endonucleases and methods for identifying new endonucleases with the same or varied specificity: e

20100330564 - Nucleic acid detection method and nucleic acid detection kit: In the present invention, an amplified DNA fragment having a first substance binding site to which a first substance is specifically bindable is prepared, which amplified DNA fragment amplified by a nucleic acid amplification method. The amplified DNA fragment is concentrated by binding the amplified DNA fragment to the first... Agent: Nixon & Vanderhye, PC

20100330570 - Nucleotide transient binding for sequencing methods: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer... Agent: Life Technologies Corporation C/o Intellevate

20100330573 - Optimized oligonucleotides and methods of using same for the detection, isolation, quantification, monitoring and sequencing of bordetella: Described herein are oligonucleotides useful for detecting, isolating, quantitating, monitoring and sequencing B. pertussis, B. parapertussis and/or the genus Bordetella, and methods of using the described oligonucleotides.... Agent: Foley & Lardner LLP

20100330572 - Organic compounds: The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the... Agent: Hamilton Desanctis & Cha, LLP

20100330565 - Reagent kit for sample analysis and sample analysis method: The present invention provides a reagent kit for analyzing a sample comprising a first reagent containing a cationic surfactant, a nonionic surfactant and an aromatic carboxylic acid and a second reagent containing a fluorescent dye capable of staining nucleic acid, and a method for analyzing a sample using the kit.... Agent: Sughrue Mion, PLLC

20100330578 - Thermo-optical characterisation of nucleic acid molecules: The present invention pertains to a method and a device for the determination of thermo-optical properties, particularly the size or size distribution, of fluorescently labeled biomolecules or biomolecule complexes, particularly nucleic acids, in a reaction solution. The method comprises the steps of: (i) providing a reaction solution with fluorescently labeled... Agent: Foley And Lardner LLP Suite 500

20100330562 - Unique calibrator polynucleotides and methods of using in quantitative nucleic acid assays: Disclosed herein are are polynucleotides which may be used to calibrate or standardize quantitative nucleic acid assays. As disclosed, the polynucleotides comprise a sequence derived from a plant viroid polynucleotide or a bacterial or chloroplast Type II intron polynucleotide. Also disclosed are methods of making and using the polynucleotides.... Agent: Office Of The Staff Judge Advocate (sks) U.s. Army Med. Research & Materiel Command

20100330587 - Annexin proteins and autoantibodies as serum markers for cancer: The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a... Agent: Arent Fox LLP

20100330583 - Compositions and methods for identification of parp function, inhibitors, and activators: The invention provides nucleic acids encoding PARP fusion proteins, PARP fusion proteins, antibodies that bind to one or more of these PARP fusion proteins, and transgenic cells expressing one or more PARP fusion proteins. The invention also provides methods for identifying an agent as a specific PARP inhibitor or activator... Agent: Clark & Elbing LLP

20100330585 - Lateral flow assay system and methods for its use: A lateral flow test system together with methods for its use in the detection of one or more analytes, or components, of interest within a sample, such as a biological sample, is provided. The system comprises a liquid formulation of a gold conjugate and a lateral flow assay device that... Agent: Speckman Law Group PLLC

20100330584 - Long wavelength fluorogenic intracellular ion indicators that are well retained in the cytosol: Cell permeable metal ion indicator compounds and methods of their use and synthesis are described. The compound comprises a metal chelating moiety (Mc), a reporter molecule and two or more lipophilic groups (GL) covalently bonded through a linker to the reporter molecule, wherein the lipophilic groups, when present in a... Agent: Life Technologies Corporation C/o Intellevate

20100330586 - Method for identifying compounds for treatment of pain: Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride levels. The methods and products may also relate to modulation of the activity and/or expression of a chloride transporter, such... Agent: Ladas & Parry LLP

20100330582 - Method for production of novel nano silica particle and use of the nano silica particle: The present invention presents a silica particle containing at least one silica compound selected from a group consisting of mercapto-propyl-trimethoxysilane (MPS), mercapto-propyl-triethoxysilane (MPES), mercapto-propyl-methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hepto-3-yl)ethyl]silane(EpoPS), thiocyanatopropyltriethoxysilane (TCPS), and acryloxypropyltrimethoxysilane (AcPS), which can be provided and utilized as a label, a marker, or the like for qualitative test and quantitative... Agent: Seed Intellectual Property Law Group PLLC

20100330590 - Assays using chimeric t1r3 taste receptor polypeptides: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20100330591 - Gpcr expressing cell lines and antibodies: The present invention provides expression vectors that facilitate high levels of expression of GPCR proteins. Encompassed by the invention are methods and compositions for recombinant cell lines expressing GPCR proteins with the aid of the expression vectors of the instant invention. The recombinant cell lines of the instant invention express... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20100330592 - Method for detecting truncated molecules: Exemplary disclosed embodiments may comprise, for example, providing a sample potentially comprising a native molecule and/or a truncated molecule. The native molecule comprises at least first and second regions recognized by first and second specific binding moieties, and the truncated molecule includes only one of the first and second regions.... Agent: Klarquist Sparkman, LLP

20100330593 - Methods and compositions for diagnosing neoplastic disease: Methods and compositions for determining whether a subject at least has a neoplastic disease are provided. In practicing the subject methods, a sample from a subject is assayed for a soluble filamin analyte, such as a filamin A analyte, to determine whether the subject at least has the neoplastic disease.... Agent: Life Technologies Corporation C/o Intellevate

20100330594 - Early detection of diabetes: The present invention is based on the discovery that hexosamine, and in particular the dynamic O-GlcNAcylation of proteins (modification of proteins by the sugar N-acetylglucosamine) both causes insulin-resistance (a hallmark of type II diabetes) and is responsible for glucose toxicity in the disease. Accordingly, the invention provides methods of diagnosing... Agent: Dla Piper LLP (us)

20100330588 - Method to quantify methyltransferase activity: The related disclosure pertains to a method to quantify methyltransferase activity. In an exemplar embodiment, the method may be carried out by the following steps: i) incubating a mixture comprising a methyltransferase, a substrate, and radiolabeled S-adenosylmethionine for a period of time sufficient for the protein methyltransferase to methylate and... Agent: Utah State University Technology Commercialization Office

20100330589 - Needle array assembly and method for delivering therapeutic agents: A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to... Agent: Wilson, Sonsini, Goodrich & Rosati

20100330595 - Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor: The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding to the mid-portion or C terminus... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20100330596 - Lipoprotein surfactant: Surfactants are provided which are particularly useful for carrying out cholesterol and triglyceride tests. These surfactants have particularly fast kinetics of response to cholesterol, cholesterol ester and triglyceride in all lipoprotein particles. Cholesterol or triglyceride sensors incorporating these surfactants therefore provide reliable measurements of the total cholesterol or triglyceride content... Agent: Roche Diagnostics Operations Inc.

20100330597 - Heat-treated limulus amebocyte lysates: The application provides heat-treated Limulus amebocyte lysates useful for detecting β-glucans.... Agent: Goodwin Procter LLP Patent Administrator

20100330598 - Method, system, and computer program product for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (hba1c) value from structured spot measurements of blood glucose: A method and system for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements are disclosed. The bG measurements and associated context of the bG measurement are collected at daily times specified by a structured sampling schema, and... Agent: Dinsmore & Shohl, LLP Fifth Third Center

20100330599 - Inhibitors of usp1 deubiquitinating enzyme complex: The invention provides compositions and methods used to inhibit USP1 deubiquitinase activity and to identify new inhibitors of USP1 deubiquitinase. The inhibitors can be used to treat or prevent cancer, bone marrow failure, and damage to cells or DNA resulting from genotoxic agents such as antineoplasic agents, including chemotherapeutic agents... Agent: Wolf Greenfield & Sacks, P.C.

20100330600 - High-molecular-weight adiponectin measurement method: Provided is a method of separating and measuring highly active HMW adiponectin in adiponectin multimers. A method of measuring high-molecular-weight adiponectin in a sample, wherein adiponectin multimers are separated by use of a protease and measured immunologically, the method comprising reacting a sample containing adiponectin multimers with chymotrypsin.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100330609 - Analysis apparatus and analysis method: This analysis apparatus includes a transporter transporting the specimens to the first measurement unit and the second measurement unit, and a control portion so controlling the transporter as to transport a first specimen container, stored in the rack, storing a first specimen to the first measurement unit and as to... Agent: Brinks Hofer Gilson & Lione

20100330612 - Biochip for electrophysiological measurements: The present invention relates to a substrate for measuring the electrophysiological properties of ion-channels located in cell membranes. The substrate is typically used in a screening device providing high-throughput industrialized measurements for studying ionic currents, particularly useful in the screening of drugs acting on the ion-channels found in cell membranes,... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20100330606 - Compositions and methods for optimizing drug hydrophobicity and drug delivery to cells: Methods to determine drug hydrophobicity and to quantify changes in drug hydrophobicity that optimize drug function by means of differential scanning calorimetry of an endothermic phase transition of a base protein-based polymer, specifically of an elastic-contractile model protein, to which is attached the drug to be evaluated for its hydrophobicity... Agent: Novak Druce + Quigg LLP

20100330601 - Control system for uv lamps, and check system for determining the viability of microorganisms: The invention relates to a control system for a method for controlling at least one UV lamp for treating a liquid such as water, wherein a biosensor is used. In addition, the invention relates to the use of biosensors for detecting or monitoring viable cells. The invention uses one or... Agent: Rissman Hendricks & Oliverio, LLP

20100330610 - Methods of processing a biological growth plate in a biological growth plate scanner: Methods are provided to process a biological growth plate using a biological growth plate scanner. The scanner includes an imaging device, a processor, and an image processing profile memory. The scanner scans a plate type indicator associated with the biological growth plate. In some embodiments, the processor uses the plate... Agent: 3m Innovative Properties Company

20100330608 - Molecular transporters based on sugar and its analogues and processes for the preparation thereof: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.... Agent: Sughrue Mion, PLLC

20100330611 - Multimodal spectroscopic systems and methods for classifying biological tissue: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with an empirical equation configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on... Agent: Howard & Howard Attorneys PLLC

20100330607 - Photoswitch-enabled ion channel assay system: The present invention provides a system for assaying ion-channels. In some embodiments, the ion-channel assay provides a reversible change to the membrane potential of a target, e.g., a cell, upon exposure to light. In some embodiments, the membrane potential readout is fed back through a control circuit to regulate the... Agent: Wilson, Sonsini, Goodrich & Rosati

20100330603 - Portable microbiological testing device for gases: A method and apparatus for microbiological testing of biogas and other gaseous streams in which a liquid bacteria growth medium disposed within a lower region of a portable sampling vessel is contacted with a gas sample of interest. The gas sample is passed through a hydrophobic filter element which retains... Agent: Mark E. Fejer Gas Technology Institute

20100330604 - Quantification of changes in the degrees of order of cellular and viral membranes and applications to diagnosis, treatment and drug screening: A method for characterizing cell membrane order in a cell. The method includes: staining the cell with di-4-ANEPPDHQ to produce a stained cell; irradiating the stained cell with an excitation light, the excitation light being capable of inducing fluorescence in the di-4-ANEPPDHQ; measuring a fluorescence spectrum of the stained cell;... Agent: Tessier & Associes

20100330605 - Test device for platelet aggregation detection: The invention relates to the test device for platelet aggregation detection comprising:—an element (1) for receiving a blood sample—a capillary tube (3) connected at a first end (31) to said element (1) and at a second end (32) to a pressure lowering device (5) to pump said blood sample through... Agent: Fulbright & Jaworski L.L.P.

20100330602 - Use of soluble galectin-3 (gal-3) for cancer treatment: The present invention provides a method for preventing or treating cancer or tumorgenesis disorder comprising administering a prevention or treatment effective amount of a p53 mediated secretome component, such as Gal-3, to a patient in need thereof, thereby preventing or treating cancer or tumorgenesis disorders. Compositions and methods useful for... Agent: Mckeon Meunier Carlin & Curfman LLC

20100330613 - Methods for determining efficacy of chemotherapeutic agents: An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying the best... Agent: Cooley LLP Attn: Patent Group

20100330614 - Global transcription machinery engineering targeting the rnap alpha subunit (rpoa): The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes.... Agent: Wolf Greenfield & Sacks, P.C.

20100330615 - Process to produce biodiesel and/or fuel oil: The present invention refers to a process to produce biodiesel and/or fuel oil from microbial oilseed and/or algal biomass and/or from sugar cane residues and derivatives. The products according to the present invention are appropriate for direct use in motors and to generate energy or steam. The integrated process of... Agent: Smith, Gambrell & Russell

20100330618 - Methods for producing biological substances in pigment-deficient mutants of bacillus cells: The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent Bacillus cell under conditions conducive for the production of the heterologous biological substance, wherein (i) the mutant cell comprises a first nucleic acid sequence directing synthesis of the heterologous biological... Agent: Novozymes, Inc.

20100330617 - Methods of producing a secreted protein: The invention is directed to methods of producing a polypeptide or a variant thereof, wherein the polypeptide or variant thereof is dependent on LIMP-2 for trafficking, localization, stabilization and/or sorting of the polypeptide in the cell. In general, the methods comprise culturing a lysosomal integral membrane protein II (LIMP-2) deficient... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100330616 - Novel endoribonuclease: A polypeptide having a novel endoribonuclease activity; a nucleic acid encoding the polypeptide; recombinant DNA having the nucleic acid therein; a transformant transformed with the recombinant DNA; a process for producing the polypeptide comprising the steps of cultivating the transformant and collecting the polypeptide from the culture; a process for... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100330619 - Direct multiplex characterization of genomic dna: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.... Agent: Lisa M. Treannie Morse, Barnes-brown & Pendleton, P.C.

20100330620 - Cellulose production by facultatively anaerobic microorganisms: A method for producing bacterial cellulose, said method comprising culturing a biologically pure culture of a cellulose-producing Proteus strain in a liquid medium suitable for culturing facultatively anaerobic microorganisms, separating bacterial cellulose produced in said liquid medium from said liquid medium, washing said separated bacterial cellulose and drying said bacterial... Agent: Gowling Lafleur Henderson LLP

20100330621 - Cellulose production by facultatively anaerobic microorganisms: A method for producing bacterial cellulose, said method comprising culturing a biologically pure culture of a cellulose-producing Proteus strain in a liquid medium suitable for culturing facultatively anaerobic microorganisms, separating bacterial cellulose produced in said liquid medium from said liquid medium, washing said separated bacterial cellulose and drying said bacterial... Agent: Gowling Lafleur Henderson LLP

20100330622 - Bacterium producing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity and a method for manufacturing the product: A method for manufacturing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity such as (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using a bacterium transformed with a DNA fragment containing a gene coding for a protein having 2-oxoglutarate-dependent enzyme activity such as L-isoleucine dioxygenase activity; and wherein... Agent: Cermak Nakajima LLP Acs LLC

20100330623 - Compositions and methods for amino acid biosynthesis: The present invention relates generally to compositions and methods useful for, inter alia, production of commercial biologic products such as amino acids. More specifically, the present invention relates to genetically modified strains of microorganisms and the use thereof for the production of commercial products. The present invention also provides, inter... Agent: Howrey LLP - East

20100330624 - Vector for transformation using transposons, microorganisms transformed by the vector, and method for producing l-lysine using the same: The present invention relates to a vector for transformation using transposon genes, microorganisms transformed by the vector, and a method for producing L-lysine using the microorganisms.... Agent: Swanson & Bratschun, L.L.C.

20100330626 - Microorganisms for the production of adipic acid and other compounds: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or... Agent: Mcdermott, Will & Emery LLP

20100330625 - Process for production of optically active indoline-2-carboxylic acid or derivative thereof: An indoline-2-cabroxylic acid is converted into an N-substituted-indoline-2-carboxylic acid, and then is esterified using a biocatalyst having a stereoselectivity in an organic solvent containing an alcohol. Next, an alkali is used to obtain an optically active N-substituted-indoline-2-carboxylic acid ester and an optically active N-substituted-indoline-2-cabroxylic acid or a salt thereof, and... Agent: Fitch, Even, Tabin & Flannery

20100330627 - Enzyme associated with equol synthesis:

20100330628 - Activated lipases and methods of use therefor: Methods for enhancing a biological (e.g., catalytic) activity of a lipase, are provided. In some embodiments, the methods include the step of alkylating one or more cysteine residues present within the lipase. Also provided are modified polypeptides for which a biological activity is enhanced by the disclosed methods, methods for... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20100330629 - Robust multi-enzyme preparation for the synthesis of fatty acid alkyl esters: Disclosed is an enzymatic process for the preparation of fatty acid alkyl esters, particularly fatty acids methyl esters (biodiesel) in a solvent-free microaqueous system, from a fatty acid source and an alcohol or alcohol donor, employing a robust lipase preparation that comprises at least two lipases separately or jointly immobilized... Agent: David S. Resnick

20100330630 - Spray dried microbes and methods of preparation and use: The invention provides spray-dried preparations of microbes and methods of using those microbes.... Agent: Schwegman, Lundberg & Woessner, P.A.

20100330631 - Cis-aconitate decarboxylase mutants having improved enzymatic activity: Cis-aconitate decarboxylase mutants having one or more mutations in a C-terminal region as compared with a wild-type cis-aconitate decarboxylase of Aspergillus terreus.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100330632 - Cis-aconitate decarboxylase mutants having improved enzymatic activity: Cis-aconitate decarboxylase mutants having one or more mutations in a C-terminal region as compared with a wild-type cis-aconitate decarboxylase of Aspergillus terreus.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100330633 - Integrated system and process for bioproduct production: Processes and systems for production of bioproducts such as biofuels are provided. The bioproduct production processes and systems utilize pretreatment of a carbohydrate-containing feedstock to produce soluble sugar molecules and continuous conversion of the pretreated feedstock to a bioproduct by an immobilized fermenting microorganism.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100330634 - Mutants having capability to produce 1, 4-butanediol and method for preparing 1, 4-butanediol using the same: A mutant capable of producing 1,4-butanediol and a method of preparing 1,4-butanediol using the same are provided. The mutant microorganism is prepared by introducing and amplifying genes encoding enzymes converting succinate into 4-hydroxybutyrate and 4-hydroxybutyrate into 1,4-butanediol in a microorganism capable of producing succinate. The method includes culturing the mutant... Agent: Mckenna Long & Aldridge LLP

20100330635 - Organisms for the production of 1,3-butanediol: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate... Agent: Mcdermott, Will & Emery LLP

20100330637 - Designer organisms for photobiological butanol production from carbon dioxide and water: The present invention provides a biosafety-guarded photobiological butanol production technology based on designer transgenic plants, designer algae, designer blue-green algae (cyanobacteria and oxychlorobacteria), or designer plant cells. The designer photosynthetic organisms are created such that the endogenous photobiological regulation mechanism is tamed, and the reducing power (NADPH) and energy (ATP)... Agent: George A. Willinghan, Iii August Law, LLC

20100330636 - Process for the biological production of n-butanol with high yield: The present invention provides a method for the biological production of n-butanol at high yield from a fermentable carbon source. In one aspect of the present invention, a process for the conversion of glucose to n-butanol is achieved by the use of a recombinant organism comprising a host C. acetobutylicum... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100330639 - Designer oxyphotobacteria and greenhouse distillation for photobiological ethanol production from carbon dioxide and water: The present invention provides a photobiological ethanol production and harvesting technology using greenhouse distillation systems with designer photosynthetic organisms, such as designer transgenic oxyphotobacteria. The designer oxyphotobacteria are created such that the endogenous photobiological regulation mechanism is tamed, and the reducing power (NADPH) and energy (ATP) acquired from the photosynthetic... Agent: George A. Willinghan, Iii August Law, LLC

20100330638 - Thermochemical treatment of lignocellulosics for the production of ethanol: A method to process lignocellulosic biomass into ethanol under conditions of high biomass loading is disclosed. Pretreatment of biomass was conducted at a high concentration of solids but with a relatively low concentration of ammonia relative to the dry weight of biomass. The pretreated biomass was washed to remove inhibitors... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20100330640 - Process: The present invention relates to a process for the production of ethanol comprising both gasification and fermentation of feedstocks, and, in particular to a process for the production of ethanol comprising: a) passing a biomass feedstock to a first fermentation step wherein it is subjected to anaerobic fermentation at a... Agent: Ineos Usa LLC

20100330641 - Method for producing ethanol: The present invention provides a method for producing an ethanol from a lignocellulose resource efficiently. According to the method for producing the ethanol of the present invention, an enzyme group derived from a mushroom waste substrate has a high activity and can allow cellulose or xylan in the lignocellulose resource... Agent: Rabin & Berdo, PC

20100330642 - Biosynthesis of 1-alkenes in engineered microorganisms: Various 1-alkenes, including 1-nonadecene and 1-octadecene, are synthesized by the engineered microorganisms and methods of the invention. In certain embodiments, the microorganisms comprise recombinant 1-alkene synthases. The engineered microorganisms may be photosynthetic microorganisms such as cyanobacteria.... Agent: Joule/fenwick

20100330643 - Cyanobacterial isolates having auto-flocculation and settling properties: Provided herein are exemplary methods for production of biomass with a cyanobacterial isolate having auto-flocculation properties. One exemplary method includes isolating a cyanobacterial strain having a 16S ribosomal RNA sequence corresponding to SEQ. ID. NO. 1 herein, inoculating an algae cultivation system with the cyanobacterial strain, growing the cyanobacterial strain,... Agent: Carr & Ferrell LLP

20100330644 - Boundary conditions for the arrangement of cells and tissues: The present invention relates to the arrangement of one or more cells in a medium or on a substrate through the use of boundary conditions, which are changes in local environment compared to the medium or substrate alone or cause an alteration of cell response upon interaction of a cell... Agent: Mccarter & English, LLP Boston

20100330645 - One pot desialylation and glycopegylation of therapeutic peptides: The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase.... Agent: Leydig Voit & Mayer, Ltd

20100330646 - Thermostable catalase: A recombinant microorganism capable of efficiently expressing thermostable catalase can be provided by obtaining a DNA necessary for efficiently producing it as a recombinant protein, and the thermostable catalase can be efficiently produced at low cost by cultivating the obtained recombinant microorganism. Hydrogen peroxide can be efficiently decomposed at low... Agent: Sughrue Mion, PLLC

20100330647 - Enzyme for the production of long chain peracid: The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods and compositions for generation of long chain peracids. Certain embodiments of the present invention find particular use in applications involving cleaning, bleaching and disinfecting.... Agent: Kamrin T. Macknight Genencor International, Inc.

20100330648 - Method and system for preparing biomass for biotreatment in a static solid state bioreactor: A method and system for preparing biomass for biotreatment in a static solid state bioreactor is performed in two stages. The first stage includes pre-mixing of the biomass with one or more reagent(s). The second stage includes the addition of a bulking agent to the pre-mixed biomass after a time... Agent: Dickstein Shapiro LLP

20100330649 - Expression systems for functional membrane polypeptides: Expression systems and methods for the expression of functional membrane polypeptides such as human cytochrome b5 are provided. The systems include recombinant expression vectors capable of expressing soluble fusion proteins that include a solubilizing agent, a linker, and a membrane polypeptide, as well as one or more cleavers, e.g. proteases,... Agent: Quarles & Brady LLP

20100330650 - Recombinant vaccine against japanese encephalitis virus [jev] infection and a method thereof: The present invention relates to a method for preparing recombinant adenovirus (RadEs) vaccine to protect against JEV infection. The vaccine produces secretory envelop protein (ES) of JEV.... Agent: Ladas & Parry LLP

20100330652 - Method and device for photochemical process: Photochemical process and device adapted to breed, produce, or hydrocultivate microorganisms. The process includes conveying a reaction medium in a reactor in a meander-shaped way that includes moving the reaction medium along a direction that perpendicularly or inclined at an angle to an imaginary horizontal plane, wherein, during the conveying,... Agent: Greenblum & Bernstein, P.L.C

20100330651 - System and methods for anaerobic environmental microbial compartmentalized cultivation: The invention described below relates to an enclosed cell sorting device and methods of using the device. The device is constructed so that the entire process of cell sorting can be conducted under fully anaerobic conditions to retain viability of anaerobic cells before, during, and after cell sorting. This is... Agent: Synthetic Genomics, Inc. C/o Dla Piper LLP (us)

20100330655 - Cellulose production by facultatively anaerobic microorganisms: A method for producing bacterial cellulose, said method comprising culturing a biologically pure culture of a cellulose-producing Proteus strain in a liquid medium suitable for culturing facultatively anaerobic microorganisms, separating bacterial cellulose produced in said liquid medium from said liquid medium, washing said separated bacterial cellulose and drying said bacterial... Agent: Gowling Lafleur Henderson LLP

20100330653 - Method for nutrient pre-loading of microbial cells: A method is provided for supporting the growth of selected microbial cells and for obstructing the growth of contaminants in a non-sterile system. In the method, the microbial cells are pre-loaded with a surplus amount of a chosen nutrient, such as phosphorus, other macronutrients, or micronutrients. Further, the chosen nutrient... Agent: Nydegger & Associates

20100330656 - Method for the production of overproducing staphylococcus aureus strains: m

20100330654 - Methods and apparatus for handling microbial samples: This invention pertains to the general field of microbiology, and more specifically to transfer, inoculation and/or streaking of micro-organisms, e.g. for the purpose of obtaining individual colonies. Provided is a method for streaking a microbial sample onto a solid carrier, comprising the steps of: a) contacting at least one ferromagnetic... Agent: Reed Smith LLP

20100330657 - Activin receptor-like kinases, proteins having serine threonine kinase domains and their use: A new receptor family has been identified, of activin-like kinases. Novel proteins have activin/TGF-β-type I receptor functionality, and have consequential diagnostic/therapeutic utility. They may have a serine/threonine kinase domain, a DFKSRN or DLKSKN sequence in subdomain VIB and/or a GTKRYM sequence in subdomain VIII.... Agent: Fulbright & Jaworski, LLP

20100330658 - Siliceous particles: Various aspects provide for extracting siliceous particles. Siliceous particles may include or be derived from diatoms. Certain embodiments provide for segregating suspensions into two or more segregation products. In some cases, a first product includes siliceous particles, and a second product may include hydrophobic species. Certain aspects provide for extracting... Agent: Carr & Ferrell LLP

20100330659 - Tissue processing apparatus: An apparatus (100) for processing a biological sample (101). The biological sample being arranged on a first planar surface (102) of a carrier (103). The apparatus comprises a second planar surface (104) arranged substantially parallel to said first planar surface and at a first distance from said first planar surface,... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100330660 - Cell block processing station: A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection... Agent: VistaIPLaw Group LLP

20100330661 - Peptides for detection of antibody to ehrlichia ewingii: The invention provides compositions and methods for the detection and quantification of Ehrlichia ewingii, Ehrlichia ewingii antibodies, antibody fragments, and polypeptides.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100330662 - Apparatus, system and method for consumer detection of contaminants in food stuffs: An apparatus, system and method of detecting contaminants, such as salmonella, in at least one ingestible item. The apparatus, system and method may include a disposable detector having therein at least one circuit layer, wherein a reaction of the reactant with at least a portion of the at least one... Agent: Edward F. Behm Drinker Biddle & Reath LLP

20100330663 - Incubator comprising a shaking device: An incubator (1) with an incubation chamber (2), a shaking device (4) which can be driven by a drive unit and which is used to shake receptacles (5) that can be placed in the incubation chamber (2) and that contain cell cultures, and a device chamber (3) which adjoins the... Agent: Hespos & Porco LLP

20100330664 - Treatment system utilizing a fluid replacement cartridge: A treatment system, in particular a system using a brine solution for chilling or freezing tissue samples, includes a working vessel wherein samples can be treated, and a replacement cartridge having a first compartment with an inlet, and a second compartment with an outlet, wherein the second compartment is collapsible.... Agent: Cohen, Pontani, Lieberman & Pavane LLP

20100330665 - Method for producing a cell culture substrate: To attain the object, the invention provides a method for producing a cell culture substrate comprising: a patterning substrate forming process of forming, on a base material, a cell culture patterning layer wherein a cell adhesion portion having cell adhesive properties and a cell adhesion-inhibiting portion having cell adhesion-inhibiting properties... Agent: Ladas & Parry LLP

20100330667 - Chimeric gfp-aequorin as bioluminescent ca++ reporters at the single cell level: A modified bioluminescent system comprising a fluorescent molecule covalently linked with a photoprotein, wherein said link between the two proteins has the function to stabilize the modified bioluminescent system and allowing the transfer of the energy by Chemiluminescence Resonance Energy Transfer (CRET).... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100330666 - Vectors and methods for tissue specific synthesis of protein in eggs of transgenic hens: Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to an embryonic chicken cell, so as to create a transgenic hen wherein the transgene is expressed in the hen's oviduct... Agent: Mckeon Meunier Carlin & Cufman LLC

20100330670 - Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes: The invention provides methods for depleting extraneous phenotypes from a mixed population of cells comprising the in vitro differentiated progeny of primate pluripotent stem cells. The invention also provides mixed cell populations enriched for a target cell phenotype where the mixed cell population comprises the differentiated in vitro progeny of... Agent: Geron Corporation Attn. David J. Earp

20100330669 - Fvii or fviia variants: Variants of FVII or FVIIa comprising at least one amino acid modification in position 196, 237, or 341 relative to hFVII or hFVIIa. The variants exhibit an increased clotting activity, i.e. reduced clotting time, compared to rhFVIIa.... Agent: Bayer Healthcare LLC

20100330668 - Interaction between the vhl tumour suppressor and hypoxia inducible factor, and assay methods relating thereto: The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor α subunits, by targeting HIF α for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF α subunit sequences which may modulate... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100330671 - Molecular transporters based on sugar and its analogues and processes for the preparation thereof: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.... Agent: Sughrue Mion, PLLC

20100330672 - Human stem cells originating from human amniotic mesenchymal cell layer: Neural stem cells which can be provided stably and which are free from the problem of compatibility in transplantation are disclosed. The stem cells are separated from human amniotic mesenchymal cell layer and express vimentin, nestin and BrdU which are markers of neural stem cells. The stem cells can also... Agent: Birch Stewart Kolasch & Birch

20100330673 - Methods of making enhanced, autologous fat grafts: Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are... Agent: Knobbe Martens Olson & Bear LLP

20100330674 - Cell culture support and associated method for cell growth and release: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a... Agent: General Electric Company Global Research

20100330676 - Expression of surrogate light chains: The present invention concerns surrogate light chain (SURROBODY™) constructs comprising surrogate light chain sequences with heterologous signal sequences.... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20100330677 - Improved reprogramming of mammalian cells, and cells obtained: Expression of reprogramming factors such as Sox2, klf4, c-myc, Nanog, LIN28 and Oct4 followed by culture in a MEK inhibitor and a GSK3 inhibitor reprograms tissue cells. The invention provides new uses of these inhibitors, for example in inducing completion of the transcriptional resetting of so-called pre-pluripotent (pre-iPS) stem cells,... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100330675 - Insulating polynucleotides derived from element d4z4 and their uses in transgenesis: Polynucleotides with insulating properties allowing protection of the expression of a transgene from adjacent cis elements in higher eukaryotic cells. In particular, these polynucleotides can be used for transgenesis, gene therapy and the production of recombinant proteins.... Agent: Pepper Hamilton LLP

20100330678 - Process for the stable gene interruption in clostridia: The present invention is related to a new method for interrupting multiple DNA sequences in Clostridia, even in genes recognized to be essential for the optimal growth of Clostridii by using a counter-selectable marker that would pinpoint the cells that have lost the plasmid and acquired a modified function that... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

  
12/23/2010 > patent applications in patent subcategories. patent applications/inventions, industry category

20100323344 - Detection of hepatitis c virus rna: The methods and compositions of this invention provide a means for determining the presence of Hepatitis C virus (HCV) in a sample from an individual. This is accomplished by hybridization to tissue samples using a cRNA probe that is specific for HCV. These means allow superior detection of HCV infection... Agent: Benjamin Aaron Adler Adler & Associates

20100323340 - Heteroduplex tracking assay: A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations... Agent: Frommer Lawrence & Haug

20100323341 - Heteroduplex tracking assay: A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations... Agent: Frommer Lawrence & Haug

20100323343 - Methods and compositions for analyte detection: The present invention is directed to methods and apparatus for detection of one or more analytes. Analytes include agents or components of infectious agents such as pathogenic virus, as well as enzymes, proteins and biomarkers.... Agent: Cooley LLP Attn: Patent Group

20100323345 - Methods and compositions for identifying cells by combinatorial fluorescence imaging: A method of identifying the classification of cells in situ involves labeling the cells with a set of nucleic acid probes and performing combinational fluorescence microscopic imaging. The set of probes contains groups of probes that bind to a taxon-specific or function-specific nucleotide sequence. Each probe of a group of... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20100323342 - Micro-device and method for selective and non-invasive separation and extraction of particles in polydispersed suspensions, manufacturing process and applications thereof: The present invention relates to a micro-device for selective and non-invasive separation of particles in polydispersed suspensions through the strategic use of ultrasounds, laminar flow and standing wave effects in a channel produced in a chip by means of microtechnology. Said device is a resonant multi-layer system with a modified... Agent: Ostrolenk Faber Gerb & Soffen

20100323362 - Compositions and methods for detecting nucleic acid from mollicutes: Compositions, reaction mixtures, kits and methods used in amplifying and detecting nucleic acids from various species of the class Mollicutes. Particular regions of the 23S rRNA or its gene have been identified as preferred targets for nucleic acid amplification reactions of a sample suspected containing at least one species of... Agent: Gen Probe Incorporated

20100323349 - Identification of the gene and mutation responsible for progressive rod-cone degeneration in dog and a method for testing same: Tools and methods are provided for determining whether or not a dog is genetically normal, is a carrier of, or is affected with or predisposed to progressive rod-cone degeneration. The method is based on the detection of a transversion from G to A at position corresponding to nucleotide position 1298... Agent: Hodgson Russ LLP The Guaranty Building

20100323353 - Marker assisted directed evolution: The present invention is directed at a novel method to enhance the genetic improvement of industrial microorganisms. More specifically, the present invention is directed at molecular methods for the identification of genetic variants that contribute to the genetic improvement of the microorganisms. The methods of the present invention comprise novel... Agent: Traskbritt, P.C.

20100323352 - Marker for prenatal diagnosis and monitoring: The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which... Agent: Townsend And Townsend And Crew, LLP

20100323355 - Means and methods for detection of nucleic acids: The present invention related to methods and tools for nuclease-dependent detection of nucleic acid hybridization. In these methods magnetic or magnetizable particles are used to discriminate between hybridized and non-hybridized DNA.... Agent: Philips Intellectual Property & Standards

20100323354 - Means and methods for the detection and isolation of fetal and embryonic cells and nucleic acid from maternal body fluid: The present invention is related to the use of an interaction partner of a high mobility group protein of the HMGA family for the detection of fetal and embryonic cells in a maternal body fluid.... Agent: Yamauchi & Mason LLC

20100323347 - Method for evaluating or selecting agent for preventing or curing photodamage of skin: A method for evaluating or selecting a substance capable of preventing or curing photodamage of skin is provided. Provided is a method for evaluating or selecting an agent for preventing or curing photodamage of skin, the method including: (A) contacting cells that are capable of expressing TIMP-1 gene or TIMP-1... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100323363 - Method for the treatment of a sample containing biomolecules: The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid and/or one species of protein, whereby the method comprises the following steps: A) providing a sample which contains at least... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100323367 - Method of detecting colon cancer marker: It is intended to provide a non-invasive and convenient method of detecting a tumor marker for diagnosing colon cancer which is superior in sensitivity and specificity to the existing fecal occult blood test. More specifically speaking, a method of detecting a tumor marker for diagnosing colon cancer which comprises collecting... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100323346 - Method of examining inflammatory disease and method of screening remedy for inflammatory disease: A single nucleotide polymorphism occurring on a leptin receptor gene is analyzed and an inflammatory disease is examined on the basis of the analytical data. Further, a substance capable of changing the interaction between the leptin receptor and galectin-2 is selected to thereby screen a remedy for an inflammatory disease.... Agent: Birch Stewart Kolasch & Birch

20100323348 - Methods and compositions for using error-detecting and/or error-correcting barcodes in nucleic acid amplification process: The present invention provides methods and compositions for detecting and correcting errors in nucleic acid amplification processes, and methods for using the same. In particular, barcode amplification errors are detected and corrected such that integrity in sample assignment is maintained. The methods are compatible with high throughput sequencing techniques as... Agent: Medlen & Carroll, LLP

20100323350 - Methods and devices for sequencing nucleic acids in smaller batches: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively... Agent: Medlen & Carroll, LLP

20100323359 - Methods for identifying analgesic agents: The present invention relates to the discovery that mutations in SCN9A are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the SCN9A gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are... Agent: Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein

20100323366 - Methods of selecting a dopaminergic neuron proliferative progenitor cells using lrp4/corin markers: According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as... Agent: Townsend And Townsend And Crew, LLP

20100323361 - Methods, systems and kits for detecting protein-nucleic acid interactions: Methods, systems and kits for detecting protein-nucleic acid interactions, in particular, detecting the genomic location to near-base pair resolution at which a particular protein (e.g., transcription factor) binds includes combining steps of a convention chromatin immunoprecipitation (ChIP) assay with use of an exonuclease that digests DNA strands in the 5′-3′... Agent: J. Rodman Steele Novak Druce & Quigg LLP

20100323357 - Microrna expression profiling and targeting in peripheral blood in lung cancer: A method for the diagnosis, prognosis and treatment of lung cancer by detecting at least one microRNA in peripheral blood is disclosed.... Agent: Macmillan Sobanski & Todd, LLC

20100323364 - Modified trna containing unnatural base and use thereof: In the method for introducing a noncanonical amino acid residue into a desired position in a protein, the structure of tRNA is so modified as to have improved affinity for aminoacyl-tRNA synthetase or improved specificity to aminoacyl-tRNA synthetase. An unnatural base is contained at any position in tRNA, whereby the... Agent: Birch Stewart Kolasch & Birch

20100323360 - Oligonucleotide arrangements, processes for their employment and their use: Oligonucleotide arrangements are disclosed which, in each case, have at least two oligonucleotide sequences linked via at least one spacer. A process is disclosed using the oligonucleotide arrangements for the amplification and/or detection of nucleic acid sequences with formation of crosslinked conglomerates. The process can be used, for example, for... Agent: Harness, Dickey & Pierce, P.L.C

20100323365 - Primer and probe for detecting chlamydophila caviae, as well as a chlamydophila caviae detection method using the same: According to the method for detection of Chlamydophila caviae using the primer and/or the probe of the present invention, the detection of Chlamydophila caviae can be performed more rapidly and with high precision compared with a conventional bacterial species identification method performed by culture examination and the like. In addition,... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100323356 - Small rna-dependent translational regulatory system in cell or artificial cell model: An object of the present invention is to construct an mRNA which specifically responds to a short RNA sequence and can activate, repress, and regulate the translation of the desired gene, and to construct an artificial cell model system using a liposome comprising the mRNA and a cell-free translational system... Agent: Mckeon Meunier Carlin & Curfman LLC

20100323351 - Tumor suppressor gene, p47ing3: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.... Agent: Townsend And Townsend And Crew, LLP

20100323358 - Use of kir genes for predicting response to therapy: The present invention relates to the use of at least one Killer cell immunoglobulin-like receptor gene for the identification of subjects likely to respond to tumour necrosis factor-based therapy. The invention also provides methods of identifying subjects likely to respond to tumour necrosis factor-based therapy, and finds utility in assisting... Agent: Greenlee Sullivan P.C.

20100323368 - Cytokine production-inducing antibody: The invention relates to a method of measuring the activation of an effector cell belonging to the immune system, which may or may not be transformed, using a monoclonal (AcMo) or polyclonal antibody. The invention is characterised in that it consists in: bringing into contact (i) CD16 receptor-expressing cells in... Agent: Foley And Lardner LLP Suite 500

20100323369 - Diagnostic testing process: A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100323370 - Method for determining immune system affecting compounds: The present invention relates to a method for increasing efficacy and/or possibility of therapeutic treatment of cancer, wherein any dys-regulatory mechanism, including inducing factor/s, of the production of immunoregulatory substances, including one or more cytokines, including IL-1β, IL-1Ra, IL-6, IL-10, IL-17, TNF-α, and others, is therapeutically controlled to minimise pathological... Agent: Knobbe Martens Olson & Bear LLP

20100323371 - Stromal interacting molecule knockout mouse and uses thereof: This invention relates to knockout mice for the Ca2+ sensor membrane protein STIM-1, STIM-2, or both, as well as cell lines from these knockout mice. Provided herein are various methods of use of isolated with knockout STIM-1 and/or STIM-2.... Agent: David S. Resnick

20100323372 - Immunoassay assembly and methods of use: The present invention relates to an improved system for efficiently and accurately performing immunoassays, such as ELISAs. The invention provides an immunoassay assembly which includes a flow-through unit and an aspiration pump. The immunoassay flow-through unit includes an outer seal; at least one bed support; an inner seal; and a... Agent: Intellectual Property Dept. Dewitt Ross & Stevens Sc

20100323375 - Agent and method for diagnosis on the occurrence of alzheimer's disease or the tendency to develop alzheimer's disease: Disclosed are: an agent, an apparatus and a method for the diagnosis of a disease associated with the abnormality in γ-secretase; a method for providing information for the diagnosis of a disease associated with the abnormality in γ-secretase; a method for monitoring the condition or the degree of progression of... Agent: Morrison & Foerster LLP

20100323376 - Method for measuring lipoprotein-specific apolipoproteins: The present invention is directed to methods of measuring the concentration of lipoprotein particles and/or lipoprotein-specific apolipoproteins in a biological fluid using an immunoassay, without the need of preliminary physical separation of the various types of lipoprotein particles present in the biological fluid.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100323373 - Method for the assessment of the inhibitory activity of antibodies against insulin-like growth factor i receptor: A method for the assessment of the inhibitory activity of an antibody for inhibiting the binding of IGF-1 and/or IGF-2 to IGF-1R in a lysed PBL sample of a mammal which has been treated with said antibody, characterized in that the IGF-1R protein level of said PBLs is measured as... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100323374 - Serum biomarkers for diagnosing liver fibrosis and method for measuring the same: Disclosed are serum biomarkers for diagnosing liver fibrosis and methods for measuring the same. The serum biomarkers obtained from human serum include alpha2-macroglobulin (“A2M”), vitamin D binding protein (“VDBP”), apolipoprotein AI (“ApoAI”). The methods involve with immunoassay using specific antibodies to detect the biomarkers, including enzyme-linked immunosorbent assay (“ELISA”), radio... Agent: Jackson Intellectual Property Group PLLC

20100323377 - Biochemical markers for cvd risk assessment: A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as lumican, versican, perlecan, decorin, biglycan, collagen type III, CRP, ApoE, or elastin, by a proteinase, said comprises contacting a sample such as urine or serum... Agent: Edwards Angell Palmer & Dodge LLP

20100323378 - Modified glucose dehydrogenase gene: [Means for Resolution] A modified glucose dehydrogenase (GLD) which includes a substitution of at least one amino acid residue selected from the group consisting of amino acid residues at positions 37, 69, 72, 73, 76, 78, 102, 217, 228, 240, 356, 407, 424, 437, 527, and 530 in an amino... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100323380 - Methods for diagnosing blood vessel reocclusion: The present invention features a method of diagnosing blood vessel reocclusion in a subject by detecting increased levels of sFLT-1 in a biological sample from the subject.... Agent: Clark & Elbing LLP

20100323379 - Sleep apnea: This document relates to methods and materials involved in diagnosing sleep apnea and assessing the effectiveness of a treatment for sleep apnea. For example, methods and materials for using markers to determine whether or not a mammal (e.g., a human) has sleep apnea are provided. In addition, methods and materials... Agent: Fish & Richardson P.C. (tc)

20100323381 - Classifying amyloidosis: This document provides methods and materials related to determining the identity of amyloid polypeptides in biological samples. For examples, methods and materials for identifying an amyloid polypeptide present in a fat aspirate are provided herein.... Agent: Fish & Richardson P.C. (tc)

20100323382 - Method for assaying bilirubin and assay instrument used in bilirubin assay: A method for assaying bilirubin in which a dry reagent is used, which is capable of accelerating the reaction of bilirubin oxidase, and an assay instrument to be used in the method for assaying bilirubin, are provided. The method for assaying bilirubin is characterized in that a biological sample and... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100323388 - Biochip for high-throughput screening of circulating tumor cells: Embodiments in accordance with the present invention relate to the use of effusive filtration to segregate tumor cells from a sample of bodily fluid. In one embodiment, fluid containing a cell is flowed down a channel having a filtration medium present along at least one side wall. The tumor cell... Agent: Townsend And Townsend And Crew, LLP

20100323389 - Fluorescent imaging with substituted cyanine dyes: b

20100323384 - Labeling of human epidermal stem cells: The present invention provides skin equivalents comprising human epidermal stem cells which are specifically labeled. The labeling is carried out with a marker capable of labeling slowly proliferating cells, e.g. iododeoxyuridine or PKH26. Particularly, the invention provides skin equivalents comprising labeled epidermal stem cells. The invention also provides corresponding uses... Agent: Birch Stewart Kolasch & Birch

20100323386 - Method and apparatus to indicate combustor performance for processing chemical/biological contaminated waste: Methods and apparatus are used for monitoring the effectiveness of a heat treatment to inactivate a contaminant in or on common building materials. The temperature is monitored or evaluated by using an internal control having a biological, chemical or electronic sensor. The sensor is bundled in common building materials to... Agent: Hendricks And Associates

20100323390 - Method for the identification of a metabolic pathway family by means of positive selection: The invention relates to the direct selection of metabolic pathways having a determined function in the transformation of a substrate {Ai} into a target product {B}, which is of interest in the industrial, pharmaceutical or agri-food sectors. More specifically, the invention relates to the detection, within metagenomic libraries, of novel... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100323383 - Methods for in vitro differentiation of th-17+cells: The instant method may be used to generate a population of human T helper lymphocytes that express IL 17 (Th-IL 17+ cells) in vitro. Methods for screening to identify agents capable of modulating Th-IL17+ cell differentiation are also encompassed by the present invention. Isolated, pure populations of homogeneous Th-IL17+ cells... Agent: Klauber & Jackson

20100323385 - Nitrogen independence identifies a highly malignant population of tumor stem cells: The present invention is directed to a method for isolating and establishing Growth Factor-Independent (GF-I) Tumor Stem Cells (TSCs) from tumor biopsies or tumor cell lines consisting in culturing cells in serum-free mitogen-free culture medium. The method discloses cell growth in a culture medium, which does neither comprise serum, nor... Agent: Abelman, Frayne & Schwab

20100323387 - Optimization of response to light: Various aspects provide for exposing a substance to light. Certain aspects include exposing a suspension of photosynthetic organisms to sunlight, and may include optimizing exposure to improve photosynthesis conditions. Certain embodiments include controlling an opacity or opacity profile of a suspension of algae and/or diatoms. Optimizing exposure may include maximizing... Agent: Carr & Ferrell LLP

20100323392 - Metering technique for lateral flow assay devices: A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone... Agent: Dority & Manning, P.A.

20100323391 - Method of detecting microorganisms with a specimen: h) Distributing one of the aforesaid diluted samples from step (g), volume by volume, into two tubes, T1 and T2, tube T1 remaining in a protective enclosure protecting diluted samples from external electromagnetic field interferences, and acting as a reference solution, tube T2 being also placed in a protective enclosure,... Agent: Arent Fox LLP

20100323394 - Integrated filtration and detection device: An integrated filtration and detection device for collecting and detecting the growth of microorganisms in a specimen includes a container defining a chamber therein. The container has an inlet and an outlet in fluid communication with the chamber. A filter is mounted in the chamber between the inlet and the... Agent: Biomerieux, Inc. Patent Department

20100323393 - Ordered assembly of membrane proteins during differentiation of erythroblasts: Disclosed herein are methods for the isolation, identification, and quantification of red blood cells and red blood cell precursors at different developmental stages. Also disclosed are methods for monitoring ex vivo proliferation and differentiation of red blood cells and red blood cell progenitors.... Agent: K&l Gates LLP

20100323395 - Method for automatically processing tissue samples in a tissue processor: In the automatic processing of tissue samples in a tissue processor, the tissue samples are placed in a retort of the tissue processor. The tissue samples are exposed to a fixation reagent (FIX) in the retort. Afterwards, the tissue samples are exposed to a dehydrating reagent (ALK). Thereafter, the retort... Agent: Hodgson Russ LLP The Guaranty Building

20100323396 - Platelet measurement reagent, platelet measurement reagent kit, and platelet measurement method: A reagent for measuring platelets comprising Nile Blue hydrogensulfate, or Nile Blue and an acid, a reagent kit for measuring platelets comprising the reagent for measuring platelets, and a method for measuring platelets using the reagent or reagent kit.... Agent: Sughrue Mion, PLLC

20100323398 - Baculoviruses with enhanced virion production and a method for the production of baculoviruses: The present invention provides a method for restoring budding capability to GP64null baculoviruses including gp64null AcMNPV by expressing therein a portion of the VSV G protein gene or a truncated “stem” portion of the GP64 gene. Other embodiments provide methods to use portions of the G-stem or GP64 protein to... Agent: Brown & Michaels, PC 400 M & T Bank Building

20100323400 - Compositions and methods for controlling copy number for a broad range of plasmids and uses thereof: The present invention provides compositions and methods for controlling the copy number for a broad range of plasmids and uses thereof. Disclosed is a host cell for conditional control of copy number of a plasmid, which host cell comprises a poly(A) polymerase gene that is operably joined to a conditionally... Agent: Quarles & Brady LLP

20100323397 - Modified vird2 protein and its use in improved gene transfer: There is provided a method for Agrobacterium-mediated gene transformation of a host cell. The method uses an Agrobacterium which expresses a VirD2 protein resistant to cleavage by a caspase. The VirD2 protein is modified by replacement of an aspartic acid residue with an alternative amino acid at one or more... Agent: Pepper Hamilton LLP

20100323399 - Use of trail polypeptides to treat cancer: A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.... Agent: Marshall, Gerstein & Borun LLP

20100323401 - General method for generating human antibody responses in vitro: This invention relates to an in vitro method of producing antigen specific B cells and antibodies that provides for the capture of an entire primary human antibody repertoire for any foreign antigen, allows for screening large numbers of immunogen/adjuvant combinations, and permits the isolation of human monoclonal antibodies on demand... Agent: Moore & Van Allen PLLC

20100323402 - Udp-glucuronyl transferase and polynucleotide encoding the same: The present invention provides a novel UDP-glucuronosyltransferase and a polynucleotide encoding the same (for example, a polynucleotide comprising a polynucleotide consisting of one nucleotide sequence selected from the group consisting of the nucleotide sequence at positions 1 to 1359 in the nucleotide sequence represented by SEQ ID NO: 4, the... Agent: Greenblum & Bernstein, P.L.C

20100323403 - Polypurine tract modified retroviral vectors: An integration-defective retroviral vector transfer cassette lacking a functional polypurine tract (PPT) is provided. Also provided are isolated nucleic acids that include a heterologous nucleotide sequence, one or two retroviral long terminal repeats (LTRs), a packaging signal, a rev responsive element, and a eukaryotic promoter, wherein the nucleic acid lacks... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20100323405 - Droplet-based nucleic acid amplification in a temperature gradient: A method of amplifying a nucleic acid, the method comprising cycling an amplification-ready droplet through a temperature gradient to locations within the temperature gradient suitable for effecting steps in an amplification reaction.... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20100323404 - Method for recombining dna sequences and compositions related thereto: Provided herein are methods for manipulating nucleotide sequences that permit greater control of sequence recombination compared to traditional methods, and related compositions. In one such method, a set of oligonucleotides and at least one primer are provided, where the primer has a first region uniquely complementary to a sequence of... Agent: Knobbe Martens Olson & Bear LLP

20100323406 - Mutant dna polymerases and methods of use: The present invention provides mutant DNA polymerases, polynucleotides encoding the polymerases, cassettes and vectors including such polynucleotides, and cells containing the polymerases, polynucleotides, cassettes, and/or vectors of the invention. The present invention also provides methods for synthesizing polynucleotides and kits including a DNA polymerase of the invention.... Agent: Life Technologies Corporation C/o Intellevate

20100323407 - Manufacturing method of separating and purifying neoagarooligosaccharides having degrees of polymerization from 2 to 22: A manufacturing method of separating and purifying neoagarooligosaccharides having degrees of polymerization of 2-22 includes the steps of adding crude enzyme solutions with agarases produced by Pseudomonas vesicularis MA103 and Aeromonas salmonicida MAEF108, respectively, into an agar polysaccharide extract solution, and obtaining a neoagarooligosaccharides solution after a hydrolysis on the... Agent: Bacon & Thomas, PLLC

20100323408 - Mutant strains of pseudomonas fluorescens and variants thereof, methods for their production, and uses thereof in alginate production: It is described biologically pure bacterial cultures of mutant strains of Pseudomonas fluorescens, which produces large amounts of alginate. The alginate may contain a certain determined content of mannuronate and guluronate residues, possible presence and determined level of acetyl groups in the alginate, and a desired molecular weight of the... Agent: Pepper Hamilton LLP

20100323409 - Process for producing (2s,3r,4s)-4-hydroxy-l-isoleucine: A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using an L-isoleucine-producing bacterium transformed with a DNA fragment containing a gene coding for a protein having L-isoleucine dioxygenase activity; and having the ability to produce (2S,3R,4S)-4-hydroxy-L-isoleucine.... Agent: Cermak Nakajima LLP Acs LLC

20100323410 - Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester: Disclosed is a method for the preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester, comprising the asymmetric reduction of arylketone and the carbamation of alcohol.... Agent: Gibbons P.C.

20100323411 - Process of producing glutamate derivatives: The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100323412 - Novel gene sms 44: The present invention relates to novel genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C) and/or 2-keto-L-gulonic acid (hereinafter also referred to as 2-KGA). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and... Agent: Nixon & Vanderhye, PC

20100323415 - Emulsions in enzymatic reactions: A reaction medium for enzyme-catalyzed reactions is provided, comprising an oil-in-water emulsion including water, an emulsifier, an oil phase and at least one interfacially active enzyme, where the emulsion is produced by the phase inversion temperature process and has a droplet size of 50 to 400 nm. A method for... Agent: Fox Rothschild LLP

20100323413 - Production of oil in microorganisms: The invention provides methods of manufacturing oils and oil-based products such as transportation fuels, industrial chemicals, edible oils, lubricants and plastics using sucrose feedstocks from sugar cane, sugar beets, and molasses for bioproduction processes. The disclosed processes utilize oleaginous microbes as a conversion technology to convert chemical energy produced by... Agent: Townsend And Townsend And Crew LLP/solazyme, Inc.

20100323414 - Production of oil in microorganisms: The invention provides methods of producing lipids by oleaginous microorganisms. The invention also provides genetically engineered oleaginous microorganisms and methods of cultivation for lipid production. Also provided are oils, fuels, oleochemicals, chemical precursors, and other compounds manufactured such microorganisms. Exemplary oleaginous microorganisms include oleaginous fungi and such oleaginous fungi that... Agent: Townsend And Townsend And Crew LLP/solazyme, Inc.

20100323416 - Fermentation method using a magnesium compound containing oxygen: This invention is directed to methods of obtaining a high quantity of desired acid salt in a form that is relatively easy to recover. Particularly desired as a recovery product is an organic acid. A salt form of the desired organic acid is formed that is relatively high in concentration... Agent: Dickinson Wright PLLC

20100323417 - Carbon capture in fermentation: The invention relates to methods of capturing carbon by microbial fermentation of a gaseous substrate comprising CO. The methods of the invention include converting CO to one or more products including alcohols and/or acids and optionally capturing CO2 to improve overall carbon capture. In certain aspects, the invention relates to... Agent: Occhiuti Rohlicek & Tsao, LLP

20100323418 - Organisms for the production of isopropanol, n-butanol, and isobutanol: A non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. The pathway includes an enzyme selected from a 4-hydroxybutyryl-CoA dehydratase, a crotonase, a 3-hydroxybutyryl-CoA dehydrogenase, an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, an acetoacetyl-CoA hydrolase, an acetoacetate decarboxylase, and an... Agent: Mcdermott, Will & Emery LLP

20100323419 - Methods and devices for charged molecule manipulation: Systems and methods for manipulating molecular material are provided. In one aspect, for example, a method for manipulating molecular material may include positioning an uncharged needle structure in electrical proximity with a charged molecular material at a first locus in a liquid environment, charging the needle structure such that at... Agent: Thorpe North & Western, LLP.

20100323421 - Method for chemically modifying biopolymer and polypeptide: It is an object of the present invention to provide a method for chemically modifying biopolymer and polypeptide with a hydrophobic compound or a compound which causes degradation or reaction under basic condition. The present invention provides a method for producing a chemically modified biopolymer or polypeptide, wherein a biopolymer... Agent: Sughrue Mion, PLLC

20100323422 - Peg-urate oxidase conjugates and use thereof: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100323420 - Regulated apoptosis: We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells.... Agent: Ropes & Gray LLP Iprm - Floor 43

20100323423 - Peg-urate oxidase conjugates and use thereof: A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100323424 - Targeted modification of chromatin structure: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.... Agent: Robins & Pasternak

20100323425 - Detection of nucleic acid differences using combined endonuclease cleavage and ligation reactions: The present invention is a method for detecting DNA sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide deletions. Labeled heteroduplex PCR fragments containing base mismatches are prepared. Endonuclease cleaves the heteroduplex PCR fragments both at the position containing the variation... Agent: Nixon Peabody LLP - Patent Group

20100323426 - Heterologous and homologous cellulase expression system: The present invention provides filamentous fungi that express a combination of heterologous and homologous polypeptides, polypeptide mixtures comprising a combination of heterologous and homologous polypeptides and methods of producing the polypeptide mixtures.... Agent: Danisco US Inc. Attention: Legal Department

20100323427 - Insulin degrading enzyme crystals: The present invention provides apo crystals and co-crystals of insulin-degrading enzyme (IDE) and their uses in drug development.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100323428 - Attenuated minus-stranded rna virus: An objective of the present invention is to provide attenuated minus-strand RNA viruses. The present inventors discovered that the amino acid mutation at position 1214 (Y1214F) in the amino acid sequence of L protein of Sendai virus suppressed the viral genome replication activity and/or transcription activity. The inventors also found... Agent: Clark & Elbing LLP

20100323430 - Media for membrane ion exchange chromatography: Media for chromatographic applications, wherein the media is a membrane having a surface coated with a polymer such as a polyethyleneimine. The immobilized polymer coating is modified with a charge-modifying agent to impart quaternary ammonium functionality to the media. The media is well suited for chromatographic purification of virus.... Agent: Nields, Lemack & Frame, LLC

20100323429 - Methods for purifying baculovirus: The present invention provides a method for purifying baculovirus comprising: providing a baculovirus mixture containing a baculovirus and a liquid portion; replacing the liquid portion with a binding buffer by an ultrafiltration system to form a virus buffer; and purifying the baculovirus from the virus buffer using glycoprotein specific affinity... Agent: Andrews & Kurth, L.L.P.

20100323431 - Bi-stable display fail safes and devices incorporating the same: A control circuit and method for controlling a bi-stable display having bi-stable segments each capable of transitioning between an on state and an off state via application of a voltage are disclosed. The voltage is provided to a display driver from a charge pump, and supplied to individual ones of... Agent: Dinsmore & Shohl, LLP Fifth Third Center

20100323432 - Sample processing device for microchip: A sample processing device for a microchip, including: a sample vessel for packing a sample therein; and a reaction vessel which is continuous with the sample vessel through a channel, and to which the sample is sequentially delivered to be packed and mixed therein, in which the sample is repeatedly... Agent: Young & Thompson

20100323433 - Hinged cap for diagnostic device: A hinged cap for engaging a housing of a diagnostic device comprises a central body; two arms extending from opposing sides of one end of said central body, said arms being substantially parallel; each of said arms comprising a cap hinge member for engaging a housing hinge member on said... Agent: Sim & Mcburney

20100323434 - Compartmentalized nerve culture system: The present invention relates generally to a compartmentalized nerve culture system. The compartmentalized nerve culture system has numerous applications including isolation of axons and cell bodies. The present invention has broad application for basic and pre-clinical research including, but not limited to, use in neuroscience, neuronal culture systems, co-culture systems,... Agent: Stein Mcewen, LLP

20100323435 - Injection system for bio-fuel reactor: The bio-fuel reactor injection system includes supplementing a biomass feedstock with a feedstock gas so that thermal conditions within the reactor body are optimized. The feedstock gas facilitates the flow of the feedstock through the feedstock injection system and maintains the feedstock below the feedstock's melting point until the feedstock... Agent: Usda, Ars, Ott

20100323436 - Photobioreactor for large-scale culture of microalgal: A photobioreactor for a large-scale microalgal culture. The photobioreactor includes a plurality of surface-light-source assemblies using a light emitting diode (LED) element, an organic light emitting diode (OLED) element, or a flexible LED sheet as a light source. The surface-light-source assemblies have the shape of a flat plate or a... Agent: Maier & Maier, PLLC

20100323437 - Vacuum blood collection tube: A vacuum blood collection tube (100) comprises a bottomed tube (101) composed of a low temperature resistant material that is less susceptible to low temperature fracture when cryopreserved at ultra-low temperature, a stopper (102) having a needle piercing portion (113) composed of a rubber material that can be pierced with... Agent: Connolly Bove Lodge & Hutz LLP

20100323438 - Gas and liquid tissue culture interface: An apparatus and method is described for culturing and conditioning cells on a sample. The apparatus includes a fluid delivery system that transmits gas to a first surface of a sample and transmits liquid to an opposite surface of the sample without transmitting liquid onto the first surface. Further, while... Agent: Paul T Dietz Dietz Law Office LLC

20100323439 - Microfluidic cell culture device: Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain... Agent: Casimir Jones, S.c.

20100323440 - Process for sterilizing acellular soft tissue under pressure: c

20100323441 - Method of collection and preservation of fluids and/or materials, in particular of organic fluids and/or materials containing stem cells, and device employable in such method: A method of collection and preservation of a fluid and/or a material comprises a step of determining a sampling volume that is closed and/or separated from the external environment, a step of taking a predetermined amount of fluid and/or material from the sampling volume and a step of confining the... Agent: Pearne & Gordon LLP

20100323442 - Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells: Disclosed herein are cell cultures comprising differentiated human cells and methods of producing the same. The present invention provides compositions and methods for the production of differentiated human cells from human pluripotent cells. Preferably, the differentiated cells are selected from the group consisting of mesendoderm cells, definitive endoderm cells, ectoderm... Agent: Knobbe Martens Olson & Bear LLP

20100323443 - Composition and method for enabling proliferation of pluripotent stem cells: The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, that both maintain stem cells in vitro pluripotency and enable self-renewal. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on... Agent: Fay Sharpe LLP

20100323444 - Culturing and differentiating neural precursor cells: Systems and methods have been developed for large-scale propagation and differentiation of populations of neurons and glia from neural precursor cells derived from postnatal brain. Under culture conditions containing pituitary extract and mitogenic factors, cells derived from neural stem cells can be attached to a substrate, maintained and serially passaged... Agent: Edwards Angell Palmer & Dodge LLP

20100323446 - Method of collecting placental cells: Provided herein are improved methods of collecting and recovering placental cells from a mammalian placenta, comprising, e.g., perfusing a mammalian placenta in a closed system such as a sterile bag and folding the placenta at least once during perfusion. Such folding, and perfusion, can be performed mechanically.... Agent: Jones Day

20100323445 - Methods, apparatus and systems for production, collection, handling, and imaging of tissue sections: Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue... Agent: Wolf Greenfield & Sacks, P.C.

20100323447 - Microfluidic cell culture device and method for using same: Microfluidic devices for cell culturing and methods for using the same are disclosed. One device includes a substrate and membrane. The substrate includes a reservoir in fluid communication with a passage. A bio-compatible fluid may be added to the reservoir and passage. The reservoir is configured to receive and retain... Agent: Casimir Jones, S.c.

20100323448 - Methods for producing biological substances in enzyme-deficient mutants of aspergillus niger: The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent Aspergillus niger strain in a medium suitable for the production of the heterologous biological substance, wherein (i) the mutant strain comprises a first nucleotide sequence encoding the heterologous biological substance... Agent: Novozymes, Inc.

  
12/16/2010 > patent applications in patent subcategories. patent applications/inventions, industry category

20100316988 - Method and device for filtering platelets: The present invention relates to methods for removing antiplatelet agents and anticoagulants from a platelet preparation. In one embodiment, the method includes the step of flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential... Agent: Andrews Kurth LLP

20100316990 - Biomarkers for hpv-induced cancer: Biomarkers that correlate with progression to neoplasia in human papillomavirus (HPV) induced cancer, for example cervical cancer have been identified. These biomarkers can be used to diagnosis or assist in the diagnosis of HPV-induced cancer. They can also be used to increase the positive predictive value of current screening modalities.... Agent: Pabst Patent Group LLP

20100316992 - Diagnostic test: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the... Agent: Wolf Greenfield & Sacks, P.C.

20100316991 - Human parainfluenza virus type 3 expressing the enhanced green fluorescent protein for use in high-throughput antiviral assays: Disclosed herein is a recombinant human parainfluenza virus expressing the enhanced green fluorescent protein. Methods of making and methods of using a recombinant human parainfluenza virus expressing the enhanced green fluorescent protein are also disclosed. A recombinant human parainfluenza virus expressing the enhanced green fluorescent protein was rescued and evaluated... Agent: Utah State University Technology Commercialization Office

20100316989 - Method for screening an inhibitory agent of hbv proliferation by using the interaction between hbv capsid and surface proteins based on cellular imaging: The present invention relates to a method for screening an inhibitory agent of HBV proliferation by measuring the interaction (binding strength) between capsid protein and surface protein, necessary for the proliferation of HBV, by using cellular imaging, more precisely a method for measuring changes on cellular imaging caused by the... Agent: Edwards Angell Palmer & Dodge LLP

20100316997 - Cell markers for human embryonic stem cells: Polynucleotides associated with differentiation states of stem cells are provided. Also provided are methods and kits for detecting, identifying and/or discriminating differentiated stem cells from undifferentiated ones by measuring an expression level of one or more genes, such as CBARA1 and LHX 6, in the stem cells.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100317014 - Compositions and methods for the isolation of nucleic acid: The present invention provides compositions and methods for the isolation of nucleic acids from a sample or subject. In particular, the present invention provides isolation, purification, and analysis of total DNA and RNA from a subject or sample. The compositions and methods find particular use in the isolation of nucleic... Agent: Casimir Jones, S.c.

20100316995 - Consensus coding sequences of human breast and colorectal cancers: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor)... Agent: Banner & Witcoff, Ltd.

20100317017 - Cystic fibrosis gene mutations: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further... Agent: Foley & Lardner LLP

20100316994 - Diagnosis and therapy of cancer using sgp28-related molecules: The present invention relates to methods and compositions for the diagnosis and therapy of prostate cancer which utilize isolated polynucleotides corresponding to the human SGP28 gene, proteins encoded by the SGP28 gene and fragments thereof, and antibodies capable of specifically recognizing and binding to SGP28 proteins.... Agent: Agensys C/o Morrison & Foerster LLP

20100317016 - Dyes and labeled molecules: Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high... Agent: Wilson, Sonsini, Goodrich & Rosati

20100317010 - Elf3 gene compositions and methods: ELF3 gene compositions associated with cancer are provided, including ELF3 mRNA intron retention, a novel ELF3 5′ untranslated region, and a novel Alu, Alukwd. Methods and kits using primers or probes to detect the presence of these ELF3 gene compositions are also provided. Methods for determining whether a cell comprises... Agent: Amster, Rothstein & Ebenstein LLP

20100317012 - Massive parallel method for decoding dna and rna: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise... Agent: John P. White Cooper & Dunham LLP

20100317000 - Method for diagnosing bladder cancer by analyzing dna methylation profiles in urine sediments and its kit: The present invention provides a method for detecting bladder cancer in a subject, comprising the following steps: (a) providing urine sediment sample from said subject; (b) determining methylation pattern of a given sequence within the promoter CpG islands of one or more genes (known as “gene” infra) in the samples;... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20100317009 - Method for dna double-strand break repair in vitro and applications thereof: A system and a method for DNA double-strand break repair in vitro are disclosed. Applications of the disclosed method in multiple areas are also disclosed.... Agent: Quarles & Brady LLP

20100316993 - Method for enriching a prokaryotic dna: A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of specifically binding to non-methylated CpG motifs, and separating the protein/polypeptide-DNA complex. Moreover, the application relates to a kit for... Agent: Patterson Thuente Christensen Pedersen, P.A.

20100317001 - Method of using tumour rna integrity to measure response to chemotherapy in cancer patients: Cancerous tumours vary significantly in their response to chemotherapy agents. Currently, it is difficult to reliably assess the level of tumour responsiveness to a chemotherapy regimen during or post-administration. Biomarkers of tumour sensitivity to chemotherapy agents have hitherto been unknown. Such a biomarker would expedite identification of nonresponsive patients, who... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20100317020 - Methods and compositions for detecting microorganisms: Methods of analyzing a sample for target microorganisms of interest are described. In particular, the methods are useful for detecting a variety of yeast and mold microorganisms based on the presence of a ubiquitous cell wall component, such as zymosan. Methods of analyzing a sample for fungal microorganisms using liposomes... Agent: 3m Innovative Properties Company

20100317013 - Methods and compositions for detecting spermatozoa or semen in a sample: The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fertility marker. Sptrx-3 may be detected in accordance with... Agent: Snr Denton US LLP

20100317018 - Methods and compositions for diagnosing and monitoring transplant rejection: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also... Agent: Morrison & Foerster LLP

20100316998 - Methods and compositions for empirical selection of drugs or other molecules: Methods for identification and/or selection of species having activity for a target molecule are described, as well as related compounds. In some cases, the compounds and methods may be useful in a screening process, where species that exhibit a desired property or combination of properties are identified and isolated from... Agent: Wolf Greenfield & Sacks, P.C.

20100317002 - Methods and kits for diagnosing lung cancer: Provided is a method of identifying a genetically abnormal cell in a sputum sample, the method comprising: (a) staining a sputum sample using a morphological stain so as to identify a lower airway tract cell or lung cell in the sputum sample; and (b) staining the sputum sample using fluorescent... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100317007 - Methods and systems to identify operational reaction pathways: The present invention provides a method for identifying an operational reaction pathway of a biosystem. The method includes (a) providing a set of systemic reaction pathways through a reaction network representing said biosystem; (b) providing a set of phenomenological reaction pathways of said biosystem, and (c) comparing said set of... Agent: Dla Piper LLP (us)

20100317005 - Modified nucleotides and methods for making and use same: Labeled nucleotide triphosphates are disclosed having a label bonded to the gamma phosphate of the nucleotide triphosphate. Methods for using the gamma phosphate labeled nucleotide are also disclosed where the gamma phosphate labeled nucleotide are used to attach the labeled gamma phosphate in a catalyzed (enzyme or man-made catalyst) reaction... Agent: Life Technologies Corporation C/o Intellevate

20100316996 - Nasopharyngeal cancer malignancy biomarker and method thereof: The present invention discloses a nasopharyngeal cancer malignancy biomarker and a method thereof, wherein relative hnRNP K expression is used to evaluate the malignancy of nasopharyngeal cancer. The biomarker of the present invention assists the currently-existing inspections to find out cancer in the early stage and realize early diagnosis and... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20100317008 - Nonseparation assay methods: Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support as is a member of a specific binding pair for capturing an analyte from a sample. An activator compound that activates the chemiluminescent... Agent: Beckman Coulter, Inc. Richard S. Handley

20100317003 - Novel compositions and methods in cancer with altered expression of kcnj9: The present invention relates to novel sequences for use in diagnosis and treatment of carcinomas, especially breast cancers. In addition, the present invention describes the use of novel compositions for use in screening methods.... Agent: Mcdermott Will & Emery LLP

20100317019 - Nucleic acid detection method and nucleic acid detection kit: The present invention is directed to a method with which one can detect a nucleic acid with sufficient accuracy, no matter the nucleotide length of a primer, and no matter if the analyte nucleotide consists of only a single nucleotide. Specifically disclosed is a method for detecting whether or not... Agent: Scully Scott Murphy & Presser, PC

20100316999 - Nucleic acid sequence analysis: The present invention relates to a method for determining the sequence of a polynucleotide, the method comprising the steps of: (i) reacting a target polynucleotide with a polymerase enzyme immobilised on a solid support, and the different nucleotides, under conditions sufficient for the polymerase reaction; and (ii) detecting the incorporation... Agent: Gen Probe Incorporated

20100317004 - Probes: The present invention relates to probes, methods and apparatus for the detection of the presence or absence of non-contiguous cis-located nucleic acid sequences which are characteristic of alleles including those relating to the human leukocyte antigen (HLA) which is of interest in the field of human transplantation and disease.... Agent: Life Technologies Corporation C/o Intellevate

20100317011 - Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use: The invention relates to the molecule referred to as ALK-1, and its role as a type I receptor for members of the TGF-β family. The molecule has a role in the phosphorylation of Smad-5 and Smad1, which also act as activators of certain genes. Aspects of the invention relate to... Agent: Fulbright & Jaworski, LLP

20100317006 - Sca risk stratification by predicting patient response to anti-arrhythmics: Genetic tests and methods for treatment based on markers to identify patients suffering from life-threatening ventricular tachy-arrhythmias, such as Ventricular Tachycardias (“VT”) and Ventricular Fibrillation (“VF”) that might lead to Sudden Cardiac Arrest (“SCA”) or Sudden Cardiac Death (“SCD”) are provided. Patients who cannot be sufficiently protected by medication alone,... Agent: Hahn & Voight-medtronic, Inc. Patent Applications

20100317015 - Spinocerebellar ataxia type 8 and methods of detection: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat... Agent: Mueting, Raasch & Gebhardt, P.A.

20100317023 - Biochemical markers for cvd risk assessment: A method of diagnosis of cardiovascular disease (CVD) an immunoassay to measure aggrecan fragments in said sample, and association of an elevation above a normal level with the presence of CVD, is conducted by contacting aggrecan fragments in said sample with an first antibody reactive with an N-terminal first epitope... Agent: Edwards Angell Palmer & Dodge LLP

20100317024 - Derivatives, reagents, and immunoassay for detecting levetiracetam: Levetiracetam (LEV) derivatives, methods for synthesizing LEV derivatives, and immunodiagnostic assays for LEV. The synthesis methods described herein include chirally-selective, liquid-phase synthesis steps to produce selected LEV derivatives in high-yield. LEV derivatives can include operative groups, such as: immunogenic moieties that can be used to prepare anti-LEV antibodies; antigenic moieties... Agent: Workman Nydegger 1000 Eagle Gate Tower

20100317025 - Diagnostic method for celiac sprue: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20100317021 - Fluidic antibody-containing devices and methods: The invention relates to devices and methods for analyzing a sample (and preferably preparing a sample), which is particularly used in analysis, such as analysis of a sample for a bacterium of interest.... Agent: 3m Innovative Properties Company

20100317022 - Methods of diagnosing tissue fibrosis: The present invention provides a method of diagnosing the presence or severity of tissue fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in a sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of metalloproteinases-1 (TIMP-1) in a sample from the individual;... Agent: Townsend And Townsend And Crew, LLP

20100317027 - Sulfenic acid-reactive compounds and their methods of synthesis and use in detection or isolation of sulfenic acid-containing compounds: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agent)s; L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic... Agent: Myers Bigel Sibley & Sajovec

20100317026 - Vmp-like sequences of pathogenic borrelia: The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis.... Agent: Fulbright & Jaworski L.L.P.

20100317028 - Bioassay method for yokukansan: The invention intends to find out an in-vitro bioassay system capable of ensuring qualities of yokukansan to a higher degree, and provides a bioassay method for yokukansan, comprising competitively reacting labeled ligand and a test sample containing yokukansan with cells or cell membranes expressing serotonin 1A receptors, and measuring binding... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100317034 - Primate t-lymphotropic viruses: Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population... Agent: Klarquist Sparkman, LLP

20100317035 - Use of specific t2r taste receptors to identify compounds that block bitter taste: Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives... Agent: Hunton & Williams LLP Intellectual Property Department

20100317036 - Mycobacterium antigens: There is provided a diagnostic reagent for use in the detection of M. bovis or M. tuberculosis infection in an animal, comprising a peptide which has an epitope from Mycobacterium bovis hypothetic protein Mb3645c (SEQ ID NO: 1) or an epitope from a polypeptide having at least 76% identity with... Agent: Hunton & Williams LLP Intellectual Property Department

20100317037 - Detection of mycobacterium tuberculosis bacilli: A screening test for Mycobacterium tuberculosis in patient samples includes an antibody preparation prepared against the cell wall antigens of M. tuberculosis. One embodiment of the screening test is rapid and has a negative predictive value of 95% or more. Furthermore, the use of an antibody preparation that will specifically... Agent: D'ambrosio & Menon, LLP

20100317030 - Methods and compositions for determining enzymatic activity: The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are methods of predicting the activity and/or substrated specificity of putative polyketide synthase, methods of identifying potential polyketide synthase substrates,... Agent: Foley & Lardner LLP

20100317029 - Nasopharyngeal cancer malingancy biomarker and method thereof: The present invention discloses a nasopharyngeal cancer malignancy biomarker and a method thereof, wherein relative TP expression is used to evaluate the malignancy of nasopharyngeal cancer. The biomarker of the present invention assists the currently-existing inspections to find out cancer in the early stage and achieve early diagnosis and early... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20100317031 - Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are... Agent: The Weintraub Group, P.L.C

20100317032 - Method for detecting antigen and antigen detection device: Provided is a method for detecting an antigen in a sample, the method including: bringing an unlabeled polypeptide and a labeled polypeptide into contact with an antigen in a sample, the unlabeled polypeptide being one of a pair including a VH-region polypeptide and a VL-region polypeptide which are separate and... Agent: Solaris Intellectual Property Group, PLLC

20100317033 - Methods and materials for detecting food containing allergens: This document provides methods and materials related to detecting allergens (e.g., food allergens) and/or specific antibodies in individualized consumers that are specific to an allergen (e.g., a food allergen). For example, methods and materials for assessing a food sample for the presence or absence of food allergens are provided. In... Agent: Fish & Richardson P.C. (tc)

20100317038 - Granzyme a and granzyme b diagnostics: A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include determining the concentration of GrA and/or GrB in a blood or serum sample from said subject; and comparing the concentrations to the... Agent: Kolisch Hartwell, P.C.

20100317040 - Methods and kits for diagnosing cancer: A method of diagnosing oral cancer or oral pharyngeal cancer in a subject in need thereof is provided. The method comprising determining a level or activity of at least one marker in a saliva sample of the subject, wherein a significant alteration in the level or the activity of the... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100317039 - Molding with embedded coupling particles for biomolecules: The invention relates to a molding, comprising a matrix in a material, selected from the group consisting of metal, ceramic and polymer synthetic material, and coupling particles embedded in the matrix, wherein a proportion of the surface of the molding in a geometrical form or in a regular pattern and/or... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20100317041 - Neural proteins as biomarkers for nervous system injury and other neural disorders: The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100317043 - Mass spectrometry assay for eif4e and eif4e regulon activity: Provided is a highly sensitive high throughput mass spectrometry-based quantitative assay for 4E/4E regulon pathway proteins has been developed which provides for single sample multiplexed analysis, as well as the analysis of protein phosphorylation states. It may be adapted for use as the first single sample analytical method of the... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20100317042 - Proteins activating pro-phenoloxidase system and genes encoding the same: The present invention provides novel proteins activating pro-phenoloxidase (pro-PO) system of Tenebrio molitor, genes encoding the same, methods of detecting bacterial infection in a sample using the proteins, and kits for detecting bacterial infection in a sample using the proteins. The present invention also provides a method of preparing a... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100317044 - Mass spectrometric endopeptidase assay: The activity of a selected endopeptidase in a body fluid is determined by the mass spectrometric measurement of the reaction products of reporter substrate molecules added to the body fluid. Each reporter substrate molecule includes a peptide with the cleavage motif of the endopeptidase, an anchor group A1 on one... Agent: Law Offices Of Paul E. Kudirka

20100317047 - Biomarkers of hemorrhagic shock: Methods for the use of claudin-3 as a biomarker for diagnosis and prognosis, and for monitoring the efficacy of treatment, in hemorrhagic shock (HS).... Agent: Fish & Richardson P.C. (bo)

20100317045 - Compounds used as dyes comperable to alexa fluor 350 dyes: Compounds used as dyes comperable to Alexa Fluor 350 dyes. The inventive compounds have high fluorescence quantum yield and high photostability. The dyes facilitate analysis of biological structures with enhanced sensitivity and selectivity.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20100317046 - Non-endogenous, constitutively activated versions of human g protein coupled receptor: fshr: The invention disclosed in this patent document relates to transmembrane receptors, particularly to a human G protein-coupled receptor, more particularly to a follicle stimulating hormone receptor (FSHR), and most particularly to mutated (non-endogenous) versions of the human FSHR for evidence of constitutive activity.... Agent: Arena Pharmaceuticals, Inc. Bozicevic, Field & Francis LLP

20100317048 - Novel synthetic blocking reagents: The present invention concerns novel synthetic blocking reagents for the reduction of non-specific bindings in solid phase assays that rely on biological and specific recognition, e.g., in enzyme-linked immunosorbent assays (ELISAs). The invention provides the use of compounds as blocking reagents as well as kits comprising these compounds. The compounds... Agent: Ballard Spahr LLP

20100317050 - Polypeptides for microbial detection: Polypeptides which can be activated to cause the formation of pores in a lipid membrane are disclosed. Also disclosed are polypeptide compositions for the detection of target microorganisms and methods of using said compositions.... Agent: 3m Innovative Properties Company

20100317049 - Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing... Agent: Woodcock Washburn LLP

20100317051 - Device for collecting and triggered release of a biological sample: The invention relates to a system for collecting a biological sample comprising a container having at least one open end, a closure fitting on or in said at least one open end, a holding element connected to said closure and a solid matrix on which said biological sample is deposited,... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100317052 - Process for detecting helicobacter pylori using aliphatic amides: The present invention provides a process for detecting Helicobacter pylori using aliphatic amides in which the referred amides are converted into their corresponding acids, when in contact with the bacterium. These acids are volatile or semi-volatile compounds and can be detected in the vapor phase by means of common chromatography... Agent: Kenealy Vaidya LLP

20100317053 - Process machinery for feeding pre-treated lignocellulosic materials into bioreactors for bio-fuels and biochemicals: Methods for mixing a pretreated cellulosic biomass feedstock using a centrifugal mixer prior to reactions in a bioreactor.... Agent: Nixon & Vanderhye, PC

20100317054 - Porcine dc-sign, icam-3 and lsectin and uses thereof: The present invention relates to the cloning, identification and characterization of the unique and entire genomic sequences encoding new porcine DC-SIGN and LSECtin proteins, including the novel nucleotide sequences of the full-length cDNA and genes of both pDC-SIGN gene and pLSECtin. Also provided are the nucleic acid molecules encoding newly... Agent: Anne M. Rosenblum, Esq.

20100317055 - Recombinant cell clones having increased stability and methods of making and using the same: Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention... Agent: Townsend And Townsend And Crew LLP

20100317056 - Fermentation medias and processes thereof: The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogues, exendin and enzymes such as lipase using... Agent: Fenwick & West LLP

20100317057 - Semi-recombinant preparation of glp-1 analogues: A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of recombinant expression techniques and chemical peptide synthesis.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20100317059 - Beta-glucosidase variant enzymes and related polynucleotides: The invention provides variants of the Azospirillum irakense CelA β-glucosidase that have improve β-glucosidase activity, particularly improved thermoactivity, compared to the wild type enzyme. The invention further provides related polynucleotides, vectors, host cell, and methods for making and using the variants.... Agent: Codexis, Inc.

20100317058 - Process for modifying the thermal and/or digestion properties of corn starches and corn flours: The present invention relates to processes for modifying the thermal and/or digestion properties of corn starches and corn flours.... Agent: Hunton & Williams LLP Intellectual Property Department

20100317060 - Method for highly amplifying target gene in mammalian cell and vector therefor: A vector of the present invention is a vector for amplifying a target gene in a mammalian cell, the vector including an amplification-activating fragment, which is a partial fragment of a mammalian replication initiation region and has a gene amplification activity site, and a mammalian nuclear matrix attachment region. In... Agent: Morrison & Foerster LLP

20100317061 - Novel dna cloning method relying on the e.coli rece/rect recombination system: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100317063 - Compositions for improved cdna synthesis: The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods, as well as to vectors and host cells containing such cDNA molecules and libraries. The invention also relates to kits for... Agent: Life Technologies Corporation C/o Intellevate

20100317064 - Covalent joining of dna strands to rna strands catalyzed by vaccinia topoisomerase: The present invention provides a method of covalently joining a DNA strand to an RNA strand comprising (a) forming a topoisomerase-DNA intermediate by incubating a DNA cleavage substrate comprising a topoisomerase cleavage site with a topoisomerase specific for that site, wherein the topoisomerase-DNA intermediate has one or more 5′ single-strand... Agent: Woodcock Washburn LLP

20100317062 - Hot start reverse transcription by primer design: The present teachings provide methods, compositions, and kits for performing primer extension reactions. In some embodiments, a reverse transcription reaction is performed on a target polynucleotide with a hot start primer comprising a blunt-ended self-complementary stem, and a loop, and extension products form at high temperatures but reduce extension product... Agent: Life Technologies Corporation C/o Intellevate

20100317065 - Glucanotransferase: The present invention describes an isolated polypeptide which has glucanotransferase activity, selected from the group consisting of: a) a polypeptide which has an amino acid sequence which has at least 40% amino acid sequence identity with amino acids 1 to 555, 1 to 549 or 1 to 567 of SEQ... Agent: Nixon & Vanderhye, PC

20100317066 - Bioreactor and method for producing microbial cellulose: A technique for producing microbial cellulose is provided, including: preparing a liquid medium for microbial cultivation in a container; horizontally rotating multiple hollow tubes that are fitted together or separated from one another, so that each of the hollow tubes is alternately partially immersed in the liquid medium and partially... Agent: Bacon & Thomas, PLLC

20100317067 - Promoter and a production method for l-lysine using the same: Disclosed are a nucleic acid molecule of Corynebacterium glutamicum origin, having an improved promoter activity, which is operably linked to operon encoding aspartate kinase and aspartate semialdehyde dehydrogense, a vector containing the same, a transformant transformed with the vector, and a method for the production of L-lysine using the transformant.... Agent: Seed Intellectual Property Law Group PLLC

20100317068 - Method for producing serine derivative and protein used for the same: s

20100317069 - Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid: The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing... Agent: Mcdermott, Will & Emery LLP

20100317070 - Complete liquefication of lignocellulosic agrowaste to form liquid biofuels: A process for converting lignocellulosic materials which are field residues such as cotton stalks and corn stover, process residues such as sugarcane bagasse and sweet sorghum bagasse, woody parts of energy crops such as switchgrass and miscanthus, forest residues or byproducts of the wood processing industries such as sawdust from... Agent: Moxon & Associates LLC Liberty Square Building

20100317071 - Method for the enzymatic production of fatty alcohol and/or fatty acid: The invention relates to a method for the enzymatic production of C6-C18 fatty alcohol and/or C8-C18 fatty acid, by carbon chain elongation, comprising the steps of : i) providing organic C2-C6 compounds; ii) subjecting the organic C2-C6 compounds to enzymatic carbon chain elongation in the presence of an electron donor;... Agent: Bozicevic, Field & Francis LLP

20100317072 - Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production: Described are engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing an oil comprising greater than 50 weight percent of eicosapentaenoic acid [“EPA”], an ω-3 polyunsaturated fatty acid, measured as a weight percent of total fatty acids [“% TFAs”] and having a ratio of at least 3.1 of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100317073 - Molecular approaches for the optimization of biofuel production: Embodiments of the present invention utilize rationale genetic and chemical engineering strategies to achieve even greater efficiencies in biofuel production from microalgae. These increased efficiencies may be achieved through the application of targeted and well-designed chemical and genetic engineering methods disclosed herein. The exemplary embodiments focus on increasing single cell... Agent: Calfee Halter & Griswold, LLP

20100317074 - Carbon capture in fermentation: The invention relates to methods of capturing carbon by microbial fermentation of a gaseous substrate comprising CO. The methods of the invention include converting CO to one or more products including alcohols and/or acids and optionally capturing CO2 to improve overall carbon capture. In certain aspects, the invention relates to... Agent: Occhiuti Rohlicek & Tsao, LLP

20100317075 - Novel carbonyl reductase, gene thereof and method of using the same: e

20100317076 - Strain of yarrowia lipolytica and its use in the industrial reclamation of glycerol fractions obtained during biodiesel production: An industrial method of reclaiming the glycerol fraction resulting from biodiesel production, a new strain of Yarrowia lipolytica for use in said method, and its use.... Agent: Cooper & Dunham, LLP

20100317077 - Methods for sequestering carbon dioxide into alcohols via gasification fermentation: The present invention is directed to improvements in gasification for use with synthesis gas fermentation. Further, the present invention is directed to improvements in gasification for the production of alcohols from a gaseous substrate containing at least one reducing gas containing at least one microorganism.... Agent: Ineos Usa LLC

20100317078 - Methods to improve alcohol tolerance of microorganisms: The present invention is directed to a method of producing organisms tolerant to alcohol, that includes selecting a microorganism needing tolerance to alcohol and modifying the selected microorganism under conditions effective to overproduce inositol by the microorganism compared to when the microorganism is not modified, with the modified microorganism being... Agent: Nixon Peabody LLP - Patent Group

20100317079 - Silage waste recovery process, facility, system, and product: A silo of conventional construction is provided with a collection pan at its bottom to collect effluent. The effluent can be stored and/or processed. Processing can include separation of water to concentrate the effluent. The effluent can contain fermentation product, such as alcohol, generated within the silo prior to collection,... Agent: Hahn Loeser & Parks, LLP

20100317080 - Method for the treatment of biological tissue of animal or human origin, such as porcine, bovine pericardium or human cadaver heart valves, and biological tissue treated accordingly: A method for treating glutardialdehyde-stabilised biological tissue of animal or human origin, such as porcine, bovine pericardium or human cadaver heart valves, provides a physical plasma treatment of the, in particular, collagen tissue for increasing the biocompatibility, cell colonisation and durability thereof.... Agent: Mcglew & Tuttle, PC

20100317081 - Counter-pressure filtration of proteins: A method is disclosed for filtering a protein in a liquid mixture in a manner that does not substantially damage or otherwise limit the recovery of the protein in the filtration filtrate. The method generally includes passing a liquid mixture containing a protein (e.g., an aqueous vWF mixture) through a... Agent: Marshall, Gerstein & Borun (baxter)

20100317082 - Related ribonucleases in which an amino acid sequence of a known ribonuclease is preceded by at least one residue at the n-terminus, and methods of making them recombinantly: New RNases, and methods for making them, are disclosed. Each includes an amino acid sequence that is disclosed in U.S. Pat. No. 6,239,257 B1, but that is preceded by a different N-terminus residue or leader sequence.... Agent: Mark H. Jay, P.A.

20100317083 - Methods and kits for dissociating fcgamma-receptor-igg complexes and for igg purification and detection: The inventions provides methods and kits for the dissociation of Fcγ-receptor-IgG complexes, and methods and kits for the isolation of IgG and Fc and Fab fragments of IgG.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100317084 - Recombinant bacteria comprising vectors for expression of nucleic acid sequences encoding antigens: The invention encompasses a recombinant bacterium that comprises at least one vector capable of expressing a nucleic acid sequence encoding an antigen. In particular, the bacterium comprises at least one chromosomally encoded essential nucleic acid that is altered so that it is not expressed, and at least one extrachromosomal vector.... Agent: Polsinelli Shughart PC

20100317086 - Large scale microbial culture method: A new culture method for producing high levels of a metabolite, such as succinic acid uses oxygen rich culture without pH adjustment to increase the biomass, acclimation in under oxygen lean conditions having <5% partial pressure of oxygen, and the production of high levels of succinate under oxygen deprived conditions.... Agent: Young & Thompson

20100317085 - Co-incubating confined microbial communities: This invention provides devices and methods that enable co-incubation of microorganisms. Also provided are methods of making such devices for co-incubation of microorganisms, and various applications of such devices.... Agent: Brinks Hofer Gilson & Lione

20100317087 - Modified cellulases with increased thermostability, thermophilicity, and alkalophilicity: A modified Family 6 cellulase enzyme comprising a proline residue at position 413 is provided. Genetic constructs and genetically modified microbes comprising DNA sequences encoding the modified Family 6 cellulase are also provided. Family 6 cellulases of the invention display improved thermostability, thermophilicity, alkalophilicity, or a combination thereof, relative to... Agent: Fitzpatrick Cella Harper & Scinto

20100317088 - Systems and methods for extracting lipids from wet algal biomass: Presented herein are exemplary systems and methods for extracting lipids from a wet algal biomass. An exemplary method comprises lysing a wet algal biomass with an insoluble granular lysing agent to create a lysate, creating a lipid-rich phase in the lysate, and separating the lipid-rich phase from the lysate. An... Agent: Carr & Ferrell LLP

20100317089 - Production of volatile fatty acids by means of mesophilic fermentation of sludge: A method and related apparatus for the removal of excess water from sludge, the method comprising the steps of: (1) fermenting the sludge at a temperature in the mesophilic temperature range, (2) maintaining the fermenting sludge for a predetermined period under a hydraulically quiescent condition to achieve phase separation, (3)... Agent: Conley Rose, P.C. David A. Rose

20100317090 - Waste treatment system: A process for treating mixed waste material, said process comprising a) collecting said mixed waste in bags; b) autoclaving the bags under conditions in which the bags degrade; c) separating the material from step (b) into three fractions, a first fraction comprising liquid materials, a second fraction comprising large solid... Agent: Intellectual Property / Technology Law

20100317091 - Biogas apparatus and biogas production process for integration with an ethanol production system and process: An integrated system produces ethanol and biogas from raw plant materials. The system includes a pretreatment apparatus for converting raw plant materials into sugars and a fermenter for fermenting the sugars to produce a beer including ethanol. A distillation apparatus separates the beer into the ethanol and a whole stillage,... Agent: Drinker Biddle & Reath LLP Attn: Patent Docket Dept.

20100317092 - Component measuring apparatus: A component measuring apparatus is provided with a case having a cylindrical case main body and a cover arranged to cover the base end opening section of the case main body; a chip mounting section for mounting a chip; a light measuring section for detecting a prescribed component; a printed... Agent: Buchanan, Ingersoll & Rooney PC

20100317094 - milk analysis microfluidic apparatus for detecting mastitis in a milk sample: A milk analysis apparatus for detecting mastitis in a milk sample by isolating somatic cells in the form of a pellet using centrifugal sedimentation is described. The apparatus comprises a vessel for holding the milk sample, and a centrifuge for rotating the vessel. The vessel includes an inlet for facilitating... Agent: Seed Intellectual Property Law Group PLLC

20100317093 - Flexible pouch and cartridge with fluidic circuits: Flexible pouch and flexible cartridge devices for fluid sample processing, related methods of making and using, related manufacturing systems and related instrumentation systems are described. Flexible pouches provide broad advantage in a wide variety of fields by overcoming the need for complex instrumentation, dedicated devices, and relatively high cost in... Agent: Weaver Austin Villeneuve & Sampson LLP

20100317095 - Bioreactor: Disclosed is a bioreactor, especially a plug flow bioreactor, including an agitator running along a longitudinal axis for thoroughly mixing a dry solid biomass that is to be outgassed in a fermentation chamber. In said bioreactor, an agitator shaft is mounted exclusively in two opposite end walls of the fermentation... Agent: Cohen, Pontani, Lieberman & Pavane LLP

20100317096 - Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site: Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding... Agent: Ropes & Gray LLP

20100317097 - Synthetic molecules that specifically react with target sequences: The present invention features biarsenical molecules. Target sequences that specifically react with the biarsenical molecules are also included. The present invention also features kits that include biarsenical molecules and target sequences. Tetraarsenical molecules are also featured in the invention.... Agent: Townsend And Townsend And Crew, LLP

20100317098 - Compositions and methods for diagnosing and treating cancer: The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides a soluble FZD receptor comprising an extracellular domain... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100317099 - Liquid separation from adipose tissue: Extracting or removing at least a portion of liquid phase from a whole sample using a centrifugal force is disclosed. Centrifugal forces are used to apply pressure to a whole sample and drive a liquid phase through a passage region that can be perforated and/or porous and maintain a drier... Agent: Harness, Dickey & Pierce, P.L.C

20100317100 - Compositions and methods for establishing and maintaining stem cells in an undifferentiated state: The present invention embraces compositions and methods for establishing and maintaining stem cells and inhibiting stem cell differentiation using a selective Protein Kinase C (PKC) inhibitor.... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20100317101 - Culture system for rapid expansion of human embryonic stem cells: This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described here, the role of feeder cells is replaced by components added to... Agent: Geron Corporation Attn. David J. Earp

20100317104 - Cell culture media: A serum-free media composition for maintenance or directed differentiation of human embryonic stem cells (HESCs) toward particular cell lineages is disclosed. The media comprises one or more cell nutrient media, a recombinant human albumin or equivalent thereof and optionally at least one agent involved in HESC differentiation. The media composition... Agent: Bozicevic, Field & Francis LLP

20100317102 - Cell culture method and automatic culture system using the method: A culturing method according to the present invention including a step of injecting cells extracted from a human body and a culture medium into a culture container, (2) a step of culturing cells while performing air ventilation and exchange of the culture medium in the culture container in which the... Agent: Antonelli, Terry, Stout & Kraus, LLP

20100317103 - Efficient generation of neural progenitors, neurons, and dopaminergic neurons from human embryonic stem cells: The present invention relates to a method for inducing the differentiation of neural progenitors, neurons, and dopaminergic neurons from human embryonic stem cells with high efficiency, in which neural selection can be performed by the selected media and physical methods. The invention has advantages such as higher efficiency, the effect... Agent: Casimir Jones, S.c.

20100317105 - Methods and compositions for controlling efficacy of rna silencing: Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100317106 - Harvesting target materials from centrifuged suspensions: Embodiments of the present invention are directed to harvesting a target material from a suspension using a tube and float system. A suspension suspected of containing a target material is combined with a solution having one or more labels that distinguish the target material from other materials in the suspension.... Agent: Olympic Patent Works PLLC

20100317108 - Cryopreservation of biological cells and tissues: The method involves placing an oocyte cell in a cell holder (1), securing the cell holder in a treatment station, applying a treatment solution to the cell by washing the cell with the solution, and rapidly cooling the cell holder and cell to a predetermined cryopreservation temperature for cryopreservation of... Agent: Richard M. Goldberg

20100317107 - Method and device for collecting and preserving cells for analysis: The claimed subject matter comprises a device to collect and preserve cells comprising of: (1) a collection container comprised of a tube having an open end and a closed end, a closure in the open end of the tube, a vacuum drawn to a predetermined level inside the container; and... Agent: Dobrusin & Thennisch PC

20100317111 - Cd40 agonist antibody/type 1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity: A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or separate compositions. In addition, fusion proteins and DNA conjugates which contain a type 1 interferon/CD40 agonist/antigen combination are provided.... Agent: Hunton & Williams LLP Intellectual Property Department

20100317110 - Cell-mediated delivery and targeted erosion of noncovalently crosslinked hydrogels: A method for targeted delivery of therapeutic compounds from hydrogels is presented. The method involves administering to a cell a hydrogel in which a therapeutic compound is noncovalently bound to heparin.... Agent: Mccarter & English, LLP Wilmington Basil S. Krikelis

20100317109 - Factor: Provided is a method of producing neurite outgrowth and/or development using RARβ2 and/or an agonist thereof.... Agent: Frommer Lawrence & Haug

20100317112 - Scaffolds increased specific gravity for cell culture and method for manufacturing thereof: The present invention relates to microtype scaffolds for cell culture, which have their specific gravity increased and a method for manufacturing thereof, and more specifically, relates to microtype scaffolds for cell culture, which have their specific gravity increased, by adding a chemically stable inorganic compound having a high specific gravity... Agent: Edwards Angell Palmer & Dodge LLP

20100317113 - Synthetic microcarriers for culturing cells: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide... Agent: Corning Incorporated

20100317114 - Method of generating glucose-responsive cells: The present invention provides an improved method for generating cells. The method comprises differentiation of neuronal progenitor cells and transfecting of either already differentiated or progenitor cells to generate certain cells useful for the treatment of an illness such as diabetes.... Agent: Greer, Burns & Crain

20100317115 - Methods, compositions and uses for enhancing chemical tolerance by microorganisms: Embodiments herein concern compositions and methods for enhancing chemical tolerance of biomass conversion by microorganisms. In some embodiments, enhancing tolerance of biomass hydrolysate conversion includes enhancing tolerance to low molecular weight organic compounds.... Agent: Faegre & Benson LLP Patent Docketing - Intellectual Property

  
12/09/2010 > patent applications in patent subcategories. patent applications/inventions, industry category

20100311035 - Preservation solution for organs and biological tissues: The invention relates to the field of organ and biological tissue preservation. In particular, the invention relates to machine perfusion or cold storage solutions for the preservation of organs and biological tissues for implant and/or transplant. The preservation solution includes a prostaglandin having vasodilatory, membrane stabilizing, platelet aggregation prevention upon... Agent: Blank Rome LLP

20100311036 - Methods for augmentation of cell cryopreservation: In accordance with certain embodiments of the present disclosure, a method for cryopreserving a cell is described. The method includes encapsulating a cell in a microcapsule, the microcapsule having a diameter of less than about 100 μM. The method further includes vitrifying the encapsulated cell in a vitrifying solution comprising... Agent: Dority & Manning, P.A.

20100311037 - Malonate decarboxylases for industrial applications: The present invention relates to a method for the enzymatic decarboxylation of malonic acid (propanedioic acid) derivatives catalyzed by enzymes structurally and/or functionally related to arylmalonate decarboxylase (AMDase) as isolated from microorganisms of the genus Bordetella. The present invention also relates to novel enzymes with a decarboxylase activity, useful for... Agent: Connolly Bove Lodge & Hutz, LLP

20100311038 - Near full-genome assay of hcv drug resistance: The invention relates to assays for characterization of genotypic mutations of Hepatitis C Virus (HCV) showing a resistance to anti-HCV drugs.... Agent: Hoffmann & Baron, LLP

20100311039 - Non-target amplification method for detection of rna splice-forms in a sample: Provided are methods of isolating RNA from a biological sample, methods and means for determining the presence of particular RNA splice-form variants in a biological sample, methods and means for determining the relative ratio of RNA ratios in a biological sample, and methods and means for predicting the progression of... Agent: Susan E. Shaw Mcbee

20100311042 - Amplifying bisulfite-treated template: Methods of amplifying nucleic acid are described. Primers on a solid support, e.g. a population of beads, are employed. A population of nucleic acid template molecules, wherein said nucleic acid template molecules have been treated with bisulfite, is amplified so as to create loaded beads comprising immobilized amplified nucleic acid.... Agent: Peter G. Carroll Medlen & Carrroll, LLP

20100311068 - Assay: The invention relates to process for in vitro prediction of a potentially allergenic substance wherein monocytes and/or macrophages and/or myelomonocytic cell lines are cultivated in the presence of the substance and interferon-γ, whereby productions of cytokines and/or neopterin are increased and measured. The allergic reaction may be estimated by measuring... Agent: Morrison & Foerster LLP

20100311044 - Assay kit for in-situ hybridization of rhogdi2 gene, method therefor and use thereof the assay kit: An assay kit for in-situ hybridization (Rho GDP dissociation inhibitor beta, ISH) of RhoGDI2 gene, an assay method therefor and a use of the assay kit are provided. The assay kit includes: a hybridization probe, a marker, a hybridization solution, and an enhancement reagent. The hybridization probe has a sequence... Agent: Austin Rapp & Hardman

20100311051 - Calcium-binding photoprotein, gene encoding the same and use thereof: The invention provides calcium-binding photoproteins which can detect light emission with a higher sensitivity. The proteins of the invention comprising the amino acid sequence of SEQ ID NO: 2 can be used for the detection and measurement of calcium ions. The proteins of the invention are useful as reporter proteins,... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100311045 - Cancer: The invention provides methods of diagnosis, prognosis and treatment of cancer related to the OBCAM and NTM genes. The methods are particularly suited to ovarian and colorectal cancers.... Agent: Wolf Greenfield & Sacks, P.C.

20100311071 - Compositions and methods for detecting juvenile renal dysplasia or calcium oxalate stones in dogs: The application relates to Canine Cox2 allelic variants associated with Juvenile Renal Dysplasia, primer and probe compositions and methods and kits useful in detecting, monitoring and diagnosing Juvenile Renal Dysplasia or calcium oxalate stones.... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20100311055 - Compositions and methods for terminating a sequencing reaction at a specific location in a target dna template: Compositions and methods for sequencing a template polynucleotide comprising a sequence of interest are provided herein. The compositions and methods employ at least one blocking probe that is designed to bind in a sequence-specific manner to a blocking sequence such that primer extension beyond the site where the blocking probe... Agent: Life Technologies Corporation C/o Intellevate

20100311054 - Compositions and methods for the detection of human t cell receptor variable family gene expression: Compositions and methods for the assessment of T cell receptor variable subunits. The present invention provides nucleotide sequences for the evaluation of the expression of TCRV families. These nucleotides sequences were obtained through a bioinformatic investigation of the nucleotide sequences for TCRVaα and TCRVβ families. The nucleotide sequences of the... Agent: Steptoe & Johnson PLLC

20100311050 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Arnold & Porter LLP (24126) Attn: Sv Docketing Dept.

20100311067 - Detection of maternal alcohol exposure: The present invention provides methods, compositions, and systems for detecting in utero alcohol exposure by detecting expression level changes in certain biomarkers (e.g., in placental tissue). In certain embodiments, the biomarkers are selected from glucocorticoid receptor (GR), thyroid hormone receptor alpha (TRα), iodothyronine deiodinase III (Dio3) and G-protein α-subunit (Gsα).... Agent: Casimir Jones, S.c.

20100311040 - Dna fragments, primers, kits, and methods for amplification the detection and identification of clinically relevant candida species: The present invention describes a novel molecular method based on the polymerase chain reaction (PCR) in a multiplex variant in order to detect and identify Candida species with clinical relevance, namely C. albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, C. guilliermondii, C. lusitaniae e C. dubliniensis. The strategy... Agent: Sughrue Mion, PLLC

20100311062 - E. coli o157:h7 specific assay: Disclosed are assays, methods and kits for the specific detection of E. coli O157:H7 and not E. coli O55:H7 from complex food matrices, water, a beverage sample, a fermentation broth, a forensic sample, an environmental sample (e.g., soil, dirt, garbage, sewage, air, or water), including food processing and manufacturing surfaces,... Agent: Life Technologies Corporation C/o Intellevate

20100311072 - Fluorescence polarization binding assay for characterizing glucokinase ligands: The subject matter disclosed and claimed herein concerns measuring the binding affinity of glucokinase (“GK”) using a fluorescence polarization (“FP”) assay. The FP method includes use of modified GK ligands bound to a fluorescent label. Binding affinity is determined by measuring displacement of fluorescent ligand by the known or suspected... Agent: Louis J. Wille Bristol-myers Squibb Company

20100311059 - Gender-specific separation of sperm cells and embryos: Disclosed are sperm cells or embryos comprising a labeled oligonucleotide bound to a gender-specific repeat sequence. Methods for separating sperm cells or embryos containing a labeled oligonucleotide from sperm cells not containing the labeled oligonucleotide produce gender-enriched sperm cell fractions. The separated fractions are useful in producing offspring of a... Agent: Michael Best & Friedrich LLP

20100311065 - Genetically modified microbes producing isoprenoids: Provided herein are methods of generating genetically modified yeast cells, e.g., genetically modified diploid and haploid yeast cells, that comprise novel polypeptides, and genetically modified yeast cells that persistently produce isoprenoid compounds in industrial fermentation processes, produced thereby.... Agent: Jones Day

20100311047 - Identification of cancer protein biomarkers using proteomic techniques: The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein.... Agent: Wolf Greenfield & Sacks, P.C.

20100311060 - Integrated chip carriers with thermocycler interfaces and methods of using the same: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess... Agent: Townsend And Townsend And Crew, LLP

20100311058 - Method for detecting nucleic acids by simultaneous isothermal amplification of nucleic acids and signal probe: The present invention relates to a method for detecting target nucleic acids by simultaneous isothermal amplification of the target nucleic acids and a signal probe 5 using an external primer set, a DNA-RNA-DNA hybrid primer set and a DNA-RNA-DNA hybrid signal probe. The method according to the present invention can... Agent: Christopher Paul Mitchell

20100311056 - Method for hybridizing nucleic acids: The invention relates to a method for manipulating, isolating, detecting or amplifying a target nucleic acid in a sample by hybridization with an oligonucleotide-oligocation conjugate, comprising allowing said nucleic acid to react with an oligonucleotide-oligocation conjugate comprising at least A1 and Bj linked together directly or via a linker, wherein.... Agent: Nixon & Vanderhye, PC

20100311046 - Method for the detection of chromosomal aneuploidies: The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation... Agent: Townsend And Townsend And Crew, LLP

20100311066 - Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof: The present invention provides novel isothermal methods of generating multiple copies of, detecting and/or quantifying nucleic acid sequences of interest based on limited primer extension or attachment of oligonucleotide pairs using composite RNA/DNA primers. Methods for generating multiple copies of and/or detecting and/or quantifying nucleic acid sequences, wherein products of... Agent: Wilson, Sonsini, Goodrich & Rosati

20100311063 - Methods and compositions for labeling nucleic acids: The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. Certain methods are provided that include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Other methods are provided that include... Agent: Choate, Hall & Stewart/harvard University

20100311057 - Mitochondrial dna deletion between about residues 12317-16254 for use in the detection of cancer: The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying mitochondrial DNA mutation in the sample and comparing the level of mtDNA mutation with a reference value. The methods of the invention may also... Agent: Morgan Lewis & Bockius LLP

20100311069 - Multiplex cell signalling assays: Disclosed are methods useful in multiplex cell-based assays for compound screening employing imaging instrumentation. The methods described herein offer high content information relating to the biological potency of test agents, off-target effects and cellular toxicity of potential drug candidates.... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100311064 - Multiplex nucleic acid reactions: The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.... Agent: Mcdermott, Will & Emery LLP

20100311048 - Neural crest enhancers and methods for use: DNA enhancer sequences are provided for use in constructs to identify early stage embryonic cells. The enhancer sequences can be used in parallel with short-hairpin RNA in a vector construct for endogenously regulated gene knockdowns. The disclosed enhancer sequences can be used to isolate a selected population of early stage... Agent: Christie, Parker & Hale, LLP

20100311041 - Pcr diagnostics of dermatophytes and other pathogenic fungi: Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before... Agent: Brooks Kushman P.C.

20100311049 - Pcr-based kit for detecting chlamydia trachomatis and nelsseria gonorrhoeae: The invention relates to a PCR based prototype kit for detecting Chlamydia trachomatis and Neisseria gonorrhoeae comprising: a transport medium for sample collection solution A and B, a reaction mixture having the primer for Chlamydia trachomatis and Neisseria gonorrhoeae, a gel loading dye, Agarose gel, gel running buffer and a... Agent: The Webb Law Firm, P.C.

20100311070 - Polymerase chain reaction (pcr) module and multiple pcr system using the same: Provided are a PCR module and a multiple PCR system using the same. More particularly, provided are a PCR module with a combined PCR thermal cycler and PCR product detector, and a multiple PCR system using the same.... Agent: Cantor Colburn LLP

20100311052 - Prognostic method for the determination of the suitability of biopharmaceutical treatment: The invention refers to a method for the prognosis of a disease in a subject by the administration of a biopharmaceutical treatment in a subject suffering from, or likely to suffer from the disease, the method involving the analysis of SNP polymorphisms in the subjects pattern recognition receptor genes (PRRs),... Agent: Mcdermott Will & Emery LLP

20100311061 - Real-time sequencing methods and systems: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g.,... Agent: Pacific Biosciences Of California, Inc.

20100311043 - Rna complexes, method of their production and sensors and analytical methods involving same: The invention includes RNA complexes comprising at least three monomeric units of an RNA molecule, each monomeric unit comprising an RNA polymer having first and second helical domains that have respective first and second binding sites, wherein the first binding sites are adapted to binding to one another and are... Agent: Roger A. Gilcrest

20100311073 - Sr-bi as a predictor of elevated high density lipoprotein and cardiovascular disease: The present invention relates to the field of single nucleotide polymorphisms (SNPs) and uses therefore as a predictor of diseases and conditions. Specifically, the present invention provides methods and kits useful in determining whether a subject is at increased risk for developing a cardiovascular disease by screening for the presence... Agent: Venable LLP

20100311053 - Use of clec1b for the determination of cardiovascular and thrombotic risk: The use of the single nucleotide polymorphism (SNP) of the CLEC1B gene for the identification of cardiovascular and/or thrombotic disorders or of an increased risk for developing cardiovascular and/or thrombotic disorders in a biological sample taken from an individual to be examined; the use of CLEC1B for identifying substances active... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100311079 - Assay for cardiac troponin autoantibodies: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among... Agent: Paul D. Yasger Abbott Laboratories

20100311075 - Human sodium-dependent bile acid transporter proteins: A novel sodium-dependent bile acid transporter protein, an Na+/H+ exchange transporter protein, a P-type ATPase protein and a vanilloid receptor protein, and polynucleotides encoding these proteins are useful in screening preventives/remedies for hyperlipemia, arteriosclerosis, genital diseases or digestive diseases; respiratory diseases, renal diseases or digestive diseases; pancreatic diseases, central nerve... Agent: Sughrue Mion, PLLC

20100311078 - Immunoregulation in cancer, chronic inflammatory and autoimmune diseases: The present invention primarily relates to a method for analyzing the amount of immunoregulatory integrin binding factors and/or patient endogenous antibodies which are directed against such factors, the factors having the capacity to modulate the immune functions in a subject suffering from cancer or inflammatory or autoimmune diseases, by utilizing... Agent: Knobbe Martens Olson & Bear LLP

20100311076 - Method of binding proteins to carriers by making use of tamavidins: e

20100311074 - Switch-region: target and method for inhibition of bacterial rna polymerase: The invention provides a target and methods for specific binding and inhibition of RNA polymerase from bacterial species. The invention provides methods for identifying agents that bind to a bacterial RNA polymerase, and that inhibit an activity of a bacterial RNA polymerase, through interactions with a bacterial RNA polymerase homologous... Agent: Davidson, Davidson & Kappel, LLC

20100311077 - Use of gpr100 receptor in diabetes and obesity regulation: We describe a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of a Gpr100 associated disease, in particular diabetes and obesity, the method comprising determining whether a candidate molecule is an agonist or antagonist of Gpr100 polypeptide, in which the Gpr100 polypeptide comprises the amino acid... Agent: Edwards Angell Palmer & Dodge LLP

20100311080 - Water-soluble nanocrystals through dual-interaction ligands: A dual-interaction ligand for rendering otherwise hydrophobic nanoparticles water soluble or suspendable has a hydrophilic base with a plurality of hydrophilic segments extending from a core of the base, where at least one segment or the core contains a hydrophobic groups capable of forming van der Waal interaction between hydrophobic... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100311082 - Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing... Agent: Woodcock Washburn LLP

20100311083 - Method for determining the therapeutic effectiveness of substances: The present invention relates to a method for determining the therapeutic efficacy of substances containing as agent at least one therapeutically effective, biotechnologically generated protein and/or peptide. The invention further relates to a kit and a biochip for conducting the method according to the present invention.... Agent: Latimer Intellectual Property Law, LLP

20100311084 - Methods for predicting a patient's response to egfr inhibitors: The present invention provides methods for individualizing chemotherapy for cancer treatment, and particularly for evaluating a patient's responsiveness to one or more epidermal growth factor receptor (EGFR) inhibitors prior to treatment with such agents. Particularly, the invention provides an in vitro chemoresponse assay for predicting a patient's response to a... Agent: Cooley LLP Attn: Patent Group

20100311085 - Cell assay kit and method: A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or... Agent: King & Spalding LLP

20100311087 - Cell-based antioxidant protection assay: Methods are provided herein for determining antioxidant activity of a test sample in intact cells. The method includes determining the antioxidant capacity of a test sample in intact red blood cells, wherein the test sample is added to intact red blood cells and oxidative damage is measured by alteration of... Agent: Klarquist Sparkman, LLP

20100311086 - Complement-mediated thrombophilic assay: A method for assessing the presence of an acquired thrombophilia disorder in a patient exhibiting hypercoagulation is disclosed.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20100311088 - Recombinant antigens for diagnosis and prevention of murine typhus: The invention relates to the construction of recombinant, immunodominant Rickettsia typhi proteins. The invention also relates to a method for the use of the recombinant proteins, either singly or in combination, in detection and diagnostic assays. The proteins can also be used in anti-Rickettsia typhi immunogenic formulations.... Agent: Naval Medical Research Center Attn: (code 00l)

20100311081 - Predicting cancer progression: A method of predicting the likelihood of cancer relapse in a patient undergoing treatment for cancer is provided. The binding response level of an immunoreactive material (IM) comprising thymidine kinase 1 (TK1) protein is determined in a body fluid sample of a patient and the likelihood of relapse of the... Agent: Young & Thompson

20100311089 - Compositions and methods for diagnosing patients with acute atherosclerotic syndrome: The present invention is in the field of autoimmunity. More specifically, the present invention relates to the detection of autoantibodies to domain 4 of beta 2-glycoprotein I (β2-GPI) as an indicator for atherosclerosis.... Agent: The Nath Law Group

20100311090 - Apparatus and method for measuring biomedical data using algorithm for improving reproducibility: Disclosed herein is a method and apparatus for measuring biomedical data. The method of measuring biomedical data using a biochemical reaction includes determining reaction termination time at which the biochemical reaction has been stabilized based on an average variation in a predetermined period in an early stage of measurement, and... Agent: Cantor Colburn LLP

20100311091 - Test strip and method for measuring blood cholesterol level using the same: Disclosed are a test strip and a method for measuring medical data. The test strip comprises an upper cover having one or more application holes; a lower support having one or more detected parts at positions corresponding to detecting units of the measuring apparatus; an erythrocyte and LDL cholesterol-filtering layer... Agent: Cantor Colburn LLP

20100311092 - Metabolic fuel switching biomarker: Disclosed is a method for measuring and determining whole body insulin release functionality, in which a plurality of physiologically acceptable differentially labeled carbohydrates is administered. A first administered carbohydrate label metabolizes faster than at least one of the other administered carbohydrate labels and recycling rates of at least two of... Agent: The Farrell Law Firm, LLP

20100311093 - Method of amplifying atp and user thereof: The ATP amplification method is a method for amplifying and detecting a very trace amount of exogenous ATP by allowing a fusion protein (PPK-ADK) of a polyphosphate kinase and an adenylate kinase, the fusion protein not containing ADP, to act on a mixture of ATP, AMP, and a polyphosphate compound.... Agent: Turocy & Watson, LLP

20100311094 - Allosteric modulation of ship polypeptides and uses thereof: This invention provides a method for identifying allosteric modulators of a SHIP polypeptide, wherein said SHIP polypeptide is contacted with a test compound, and wherein said SHIP polypeptide comprises an allosteric site selected from the group consisting of a SHIP C2 domain and a SHIP PH domain.... Agent: Greenberg Traurig, LLP

20100311095 - Assessment of physiological conditions: The present invention relates to a method for assessing in vitro the balance and the overall dynamics of a physiological condition, wherein a) a first biochemical marker representing a first biochemical process associated with the physiological condition is measured, b) a second biochemical marker representing a second biochemical process associated... Agent: Dinsmore & Shohl, LLP Fifth Third Center

20100311096 - Identifying molecules modulating protein-protein interactions using protease activated reporters: Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100311098 - Method for determining the amino acid sequence of peptides: The invention is in the field of analytical methods suitable for biochemical applications and provides a method for determining the amino acid sequence of a peptide. The determination of amino acid sequences of proteins and peptides is useful in the study of biological systems. The invention relates to a method... Agent: Traskbritt, P.C.

20100311097 - Stable isotope labeled polypeptide standards for protein quantitation: This invention relates to proteins having an amino acid sequence containing several amino acid subsequences found in nature and wherein at least two different subsequences act as monitor sequences, said subsequences being part of at least one natural protein which is a target protein, wherein the end of each of... Agent: Perkins Coie LLP

20100311100 - Applanation system for evaluation of cell pressure dependent firmness on leaves and soft organs flat face segments: The applanation system on air permeated screen (1) of this invention is a versatile instrument for measurement of tissue firmness generated by cell turgor pressure of leaves and organs segments with thin and elastic cell wall of several stalk, leaves, fruits and roots. It is composed by an air source... Agent: Alston & Bird LLP

20100311102 - Electrophysiology methods for identification of protein structures in membranes associated to neurodegenerative diseases: This invention corresponds to an in vitro method that employs an electrophysiology technique; in particular, an embodiment of the patch-clamp technique in its perforated type, which will allow us evaluating the neurotoxic capacity of protein structures associated to the generation of neurodegenerative diseases. It addition, it allows evaluating potential pharmacologic... Agent: Carstens & Cahoon, LLP

20100311101 - Method to predict toxicity using the analysis of dynamic organelle behaviour: The present invention provides an in vitro method to predict the effect of an exogenous element on an animal or human organism. This method is based on the analysis of variations of an organelle behaviour represented by at least two characteristics in isolated cells induced by the contact with the... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100311105 - Methods of delivery of exogenous proteins to the cytosol and uses thereof: The present invention is directed to a method for delivering exogenous proteins to the cytosol, by binding a target antigen (such as a protein) to a transport factor that contains a fragment of a bipartite protein exotoxin, but not the corresponding protective antigen. Preferably, the target antigen is fused to... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20100311104 - Novel bacteria and methods of use thereof: A novel class of bacteria is described which has improved efficiency in the production of thanol by anaerobic fermentation of substrates containing carbon monoxide.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100311106 - Quantitation of lobular involution for breast cancer risk prediction: Methods for determining risk of developing breast cancer are described.... Agent: Fish & Richardson P.C. (tc)

20100311103 - Solid support coated with at least one metal film and with at least one transparent conductive oxide layer for detection by spr and/or by an electrochemical method: One subject of the present invention is a transparent solid support coated with at least one layer of metal and with at least one layer of transparent conductive oxide (TCO), especially tin-doped indium oxide (ITO) in order to form a solid support that can be used at the same time... Agent: Foley And Lardner LLP Suite 500

20100311099 - Use of he4 for assessment of breast cancers: The disclosure relates to use of the HE4 marker to assess breast cancer in a patient. The disclosure also relates to using HE4 and other tumors markers for diagnosis, grading and staging of breast cancers. The disclosure also relates to determining prognosis and treatment effectiveness of a patient who has... Agent: Duane Morris LLP - AtlantaIPDepartment

20100311107 - Ultra-high throughput screening of natural products: The present invention provides cells having more than two drug resistance genes and at least two different resistance genes that have been recombined into the chromosome of a cell. It also teaches the processes for preparing cells by recombining two or more different drug resistance genes into the chromosome of... Agent: K&l Gates LLP

20100311108 - System and method for agitation of multiple specimen containers: A system is disclosed for agitating multiple specimen containers each containing a sample and a growth medium. The system includes a plurality of racks. The racks have a plurality of receptacles, each of which is adapted for holding a specimen container. The racks include a first rack oriented in a... Agent: Biomerieux Vitek Inc.

20100311109 - Non-contact method for quantifying changes in the dynamics of microbial populations: A method for quantifying an amount of a viable microorganism includes subjecting a fluid sample suspected of containing a viable microorganism to a temperature change, and correlating the temperature history of the fluid sample to the amount of the viable microorganism contained in the fluid sample. The method may include... Agent: King & Schickli, PLLC

20100311110 - Thermal and acid tolerant beta xylosidases, arabinofuranosidases, genes encoding, related organisms, and methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof are provided. Further provided are methods of at least partially degrading xylotriose, xylobiose, and/or arabinofuranose-substituted xylan using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof.... Agent: Traskbritt / Battelle Energy Alliance, LLC

20100311111 - Methods for optimizing production and collection of reusable gases: Methods for increasing methane emitted from organic waste and for collecting methane and other gaseous bi-products. A gas collection unit collects gas in a first separation tank, wherein the gas is separated into methane and other components. The methane is collected, and other components are diverted. A second separation tank... Agent: Keely Schneiter

20100311113 - Chemo-enzymatic peptide synthesis via c-terminal ester interconversion: The invention further relates to a method for preparing a peptide comprising coupling an activated, N-protected, amino acid C-terminal ester or an optionally N-protected peptide C-terminal ester with an optionally C-terminal protected amino acid or an optionally C-terminal protected peptide via a peptide bond, in the presence of an enzyme... Agent: Nixon & Vanderhye, PC

20100311112 - Method for amidating polypeptides with basic amino acid c-terminals by means of specific endoproteases: The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100311114 - Preparation of samples for proteome analysis: The invention mainly concerns methods and systems for the preparation of biological samples for proteome analysis, N-terminal or C-terminal peptides of proteins are enriched using exopeptidase.... Agent: Knobbe Martens Olson & Bear LLP

20100311115 - Selective enrichment of post-translationally modified proteins: The present invention relates to the selective enrichment of post-translationally modified proteins and/or peptides from complex samples. In particular, the invention relates to methods for the separation of phospho-proteins and/or -peptides and/or for the discrimination between different subsets of phospho-proteins and/or -peptides.... Agent: Philips Intellectual Property & Standards

20100311116 - Fast generation of high expression stable cell lines expressing recombinant proteins under minimal and short-term selective pressure: The present invention provides a novel method for the fast generation of high expression stable cell lines for the production of recombinant proteins with high efficacy of stable integration while using low selective pressure for only a short period of time. The method uses transiently expressed piggybac transposase to mediate... Agent: Markus Hildinger

20100311120 - Human cytokine receptor: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides polynucleotides, vectors, cells, and methods of production related to a new human cytokine receptor designated as “Zcytor16.”... Agent: Zymogenetics, Inc. Intellectual Property Department

20100311117 - Nucleic acids isolated from the intestine: A recombinant intestinal nucleic acid is provided. One embodiment of the present invention contemplates the use of a gut-specific promoter, wherein a promoter can be the chicken intestinal fatty acid binding protein promoter region. A method for making a transgenic bird is also disclosed by transfecting a bird with a... Agent: Synageva Biopharma Corp.

20100311118 - Plasmid-encoded neurotoxin genes in clostridium botulinum serotype a subtypes: The present invention provides a novel isolated plasmid, wherein the plasmid is a native plasmid found in unique C. botulinum type A strains and encode either BoNT/A3 or BoNT/A4 and BoNT/B. The present invention also provides a method of obtaining a plasmid-encoded botulinum neurotoxin and botulinum neurotoxin complex comprising the... Agent: Quarles & Brady LLP

20100311121 - Regulatory nucleic acid elements: TE elements bring about an increase in the expression of the product gene, particularly when stably integrated in the eukaryotic genome, preferably the CHO-DG44 genome. Chromosomal positional effects are thereby overcome, shielded or cancelled out. In this way the proportion of high producers in a transfection mixture and also the... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100311119 - Single-domain antigen-binding proteins that bind mammalian igg: The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to... Agent: Morgan Lewis & Bockius LLP

20100311122 - Vectors and yeast strains for protein production: Lower eukaryote host cells in which the function of at least one endogenous gene encoding a chaperone protein, such as a Protein Disulphide Isomerase (PDI), has been reduced or eliminated and at least one mammalian homolog of the chaperone protein is expressed are described. In particular aspects, the host cells... Agent: Merck

20100311124 - Methods and compositions for inactivating glutamine synthetase gene expression: Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.... Agent: Robins & Pasternak

20100311123 - Vector for expressing antibody fragments and a method for producing recombinant phage that displays antibody fragments by using the vector: Disclosed are a plasmid vector (pLA-1 or pLT-2) for producing water-soluble light chain antibody fragments (VL+CL), a phagemid vector (pHf1g3T-1 or pHf1g3A-2) having a heavy chain antibody fragments (VH+CH1)-ΔpIII fusion protein expression and genotype-phenotype linkage function, a host transformed using the vectors, and a method of producing and selecting a... Agent: Edwards Angell Palmer & Dodge LLP

20100311125 - Method for liquefying and saccharifying starch quickly: A method for liquefying and saccharifying starch quickly includes the steps of: irradiating starch with 0.25×106˜1.5×106 Gy 60Co-γ rays or electron accelerator, putting the irradiated starch into a fermenting tank and adding cold water, stirring mechanically to forma solution, adding a little amount of starch saccharifying enzyme to saccharifying the... Agent: David And Raymond Patent Firm

20100311126 - Method for in vitro recombination: The present invention relates, e.g., to an in vitro method, using isolated protein reagents, for joining two double-stranded (ds) DNA molecules of interest, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule share a region of sequence identity, comprising (a) chewing... Agent: Synthetic Genomics, Inc. C/o Dla Piper LLP (us)

20100311127 - Recombinase polymerase amplification: This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20100311128 - Method of oligonucleotide synthesis: Methods and kits for synthesizing a plurality of oligonucleotides are provided. Methods for providing a plurality of oligonucleotides enriched for full length oligonucleotides are provided. Truncated oligonucleotides are preferentially removed from the sample by digestion. Methods are also provided for amplification of a plurality of oligonucleotides.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20100311129 - Method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.... Agent: Cermak Nakajima LLP Acs LLC

20100311130 - Enzymatic ester hydrolysis: The present invention relates to a method for selectively hydrolysing a pendant ester bond formed by an unsubstituted or substituted hydrocarbon group—optionally comprising one or more heteroatoms—and a pendant carboxylate moiety, which carboxylate moiety is part of a polymer or a polymerisable compound, which polymer or polymerisable compound comprises at... Agent: Nixon & Vanderhye, PC

20100311131 - Transgenic systems for the manufacture of poly(2-hydroxy-butyrate-co-3-hydroxyhexanoate): Methods for engineering transgenic organisms that synthesize polyhydroxyalkanoates (PHAs) containing 3-hydroxyhexanoate as comonomer have been developed. These processes are based on genetically engineered bacteria such as Escherichia coli or in plant crops as production systems which include PHA biosynthetic genes from PHA producers. In a preferred embodiment of the method,... Agent: Pabst Patent Group LLP

20100311132 - Production of itaconic acid: The invention relates to the production of itaconic acid in micro-organisms by introducting into a suitable host cell a gene coding for the enzyme cis-aconitic acid decarboxylase, preferably derived from A. terreus. Further part of the invention are host cells, preferably from A. niger, provided with the above mentioned genes.... Agent: Morrison & Foerster LLP

20100311133 - Electrode, enzyme sensor using the electrode, fuel battery, electronic device, and method for decomposing polyol: An electrode that can generate reduced coenzymes from a desired substrate in multiple stages is provided. An electrode includes a 2-hydroxycarboxylic acid synthase, a 2-oxo acid synthase, and a 2-oxo acid carboxylyase. The electrode includes a 2-oxo acid carboxylyase, which is a decarboxylase, in addition to a 2-hydroxycarboxylic acid synthase... Agent: K&l Gates LLP

20100311134 - Method for producing sclareol: The present invention provides a method of producing sclareol, said method comprising contacting a particular polypeptide having a sclareol synthase activity with labdenediol diphosphate (LPP). In particular, said method may be carried out in vitro or in vivo to produce sclareol, a very useful compound in the fields of perfumery... Agent: Scully Scott Murphy & Presser, PC

20100311135 - Isopropyl alcohol- producing bacterium and method of producing isopropyl alcohol using the same: The invention provides: an isopropyl alcohol-producing bacterium which has an acetoacetate decarboxylase activity, an isopropyl alcohol dehydrogenase activity, a CoA transferase activity and a thiolase activity having been imparted thereto and is capable of producing isopropyl alcohol from a plant-derived material; a method of producing isopropyl alcohol whereby isopropyl alcohol... Agent: Foley And Lardner LLP Suite 500

20100311137 - Microorganisms having enhanced tolerance to inhibitors and stress: The present invention provides genetically modified strains of microorganisms that display enhanced tolerance to stress and/or inhibitors such as sodium acetate and vanillin. The enhanced tolerance can be achieved by increasing the expression of a protein of the Sm-like superfamily such as a bacterial Hfq protein and a fungal Sm... Agent: Scully Scott Murphy & Presser PC

20100311136 - Recombinant yeast and branched alcohol production method using recombinant yeast: e

20100311138 - Ethanol production by fermentation: A method for producing ethanol by fermentation includes the preparation of a starter culture, inoculation of a mash with the starter culture, fermentation of the mash, and recovery of ethanol from the mash. The starter culture includes a tallow base with Chinese tallow tree parts and water which are inoculated... Agent: Bradley Arant Boult Cummings LLP

20100311139 - Systems, compositions, and/or methods for depolymerizing cellulose and/or starch: Methods for depolymerizing polysaccharides are disclosed. In certain exemplary methods, polysaccharides having a first average molecular weight can be reacted with hydroxyl free radicals to produce polysaccharides having a second average molecular weight lower than the first average molecular weight. The hydroxyl free radicals can be formed by interaction of... Agent: Quarles & Brady LLP

20100311140 - Bacterium capable of fermenting glucose, mannose and xylose simultaneously, and method for production of bioethanol using the bacterium: The object is to develop a bacterium capable of fermenting glucose, mannose and xylose simultaneously, which can ferment a saccharified solution of a cellulose-type or lignocellulose-type biomass resource to produce ethanol, and to construct an energy-saving high-efficiency bioethanol conversion process. Thus, disclosed is Zymomonas mobilis bacterium which is prepared by... Agent: Birch Stewart Kolasch & Birch

20100311141 - Biogas installation for production of biogas from biomass, and methods for operation of the biogas installation: A biogas installation for production of biogas from biomass and methods for starting and shutting down a fermenter are disclosed. When biomass in a fermenter is used up, biogas production must stop, the fermented biomass removed, and the fermenter filled with fresh biomass. Biogas production and utilisation is maintained for... Agent: Morrison & Foerster, LLP

20100311142 - Novel hydrogenases isolated from thermococcus spp., genes encoding the same, and methods for producing hydrogen using microorganisms having the genes: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing... Agent: Clark & Elbing LLP

20100311143 - Enzyme electrode and method for producing the same: The present invention discloses an enzyme electrode and its producing method, which comprises: providing a substrate with a carbon surface; forming a gold surface on the carbon surface and thus forming an electrode; covalently bonding a mediator containing an aldehyde group to the electrode; and covalently bonding a glucose oxidase... Agent: Stout, Uxa, Buyan & Mullins LLP

20100311144 - Mutant dna polymerases: Provided herein are mutant DNA-dependent polymerases which are derived from, or otherwise related to, wild type RB69 DNA polymerase. These mutant polymerases are capable of selectively binding labeled nucleotides. These mutant polymerases are also capable of incorporating a variety of naturally occurring and modified nucleotides, including, for example, terminator nucleotides.... Agent: Life Technologies Corporation C/o Intellevate

20100311145 - Novel use of adenoviruses and nucleic acids that code for said viruses: The present invention is related to the use of a virus, preferably an adenovirus, for the manufacture of a medicament, whereby the virus is replication deficient in cells which do not have YB-1 in the nucleus, and the virus codes for an oncogene or oncogene product, in particular an oncogene... Agent: Lisa Mueller C/o Polsinelli Shughart PC

20100311147 - Alleles of the rel gene from coryneform bacteria: An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100311146 - Cell culture and mixing vessel: A mixing vessel (10) for containing a liquid, comprises a chamber having a lower chamber portion and an upper chamber portion wider than the lower portion, gas inlet means (14) for supplying gas to the lower portion, liquid circulation inducing means (17) and an inclined abutment (24), such that, when... Agent: Marshall, Gerstein & Borun LLP

20100311148 - Apparatus, methods and systems for handling and processing waste material: Apparatus, methods and systems for processing waste are provided. For example, a system for processing waste, wherein the waste comprises hard particulates embedded therein, can be provided. The system can comprise a waste disruptor, wherein the waste disruptor disrupts the waste and releases at least one of the embedded hard... Agent: Ropes & Gray LLP

20100311149 - Biosensor: Disclosed herein is a biosensor. The biosensor includes a measuring layer configured to measure whether reaction to a biological sample has occurred. An upper cover is disposed on a top of the measuring layer, and is provided with an open window configured to allow a measurement area of the measuring... Agent: Cantor Colburn LLP

20100311151 - Blood glucose tracking apparatus and methods: A measurement module for glucose testing includes a glucose testing measurement module housing, a test strip receptacle formed in the housing, and a connector portion formed in the housing and shaped to permit mechanical removable attachment of the housing to a hand-held computer. Electronics determine the amount of glucose present... Agent: Abbott Diabetes Care Inc. Bozicevic, Field & Francis LLP

20100311150 - Cell processing device: In a closed system having a large number of containers connected via pipes, a leakage of a liquid from the closed system can be more reliably detected by a convenient and inexpensive method. Provided is a cell processing device (1) comprising a plurality of processing containers (2a and 10) for... Agent: Scully Scott Murphy & Presser, PC

20100311153 - Method and device for processing a biological fluid for analyte determination: The present invention refers to a method of processing a biological fluid which comprises cellular components by heat treatment. The method is particularly useful for preparing biological samples for analyte detection. Further, the invention refers to a processed biological fluid comprising substantially quantitatively disintegrated cellular components.... Agent: Arent Fox LLP

20100311152 - Real-time amplification and monitoring system incorporating vector-based algorithm for analyzing polynucleotide-containing samples: System for analyzing a polynucleotide-containing sample using real-time amplification and monitoring. The system includes a computer or processing device with software for performing a vector analysis of growth curves. The vector analysis advantageously simplifies polynucleotide quantitation by circumventing the need to establish thresholds used for calculating initiation of the growth... Agent: Gen Probe Incorporated

20100311154 - Test strip designed to improve spreadability of blood: Disclosed is a test strip for measuring medical data, in which a hydrophilic material is introduced to improve the spreadability of blood. Having the structure comprising a blood-filtering layer designed to filter off either or both of erythrocytes and low-density lipoprotein (LDL) cholesterol from an applied blood sample; a reaction... Agent: Cantor Colburn LLP

20100311155 - Method for treatment of organic material: The present invention relates to a disintegrating system for treatment of organic material comprising: multiple disintegrating units (31, 32; 41, 42; 51, 52, 53) each having an inlet (33, 34; 43, 44; 55, 56, 57) for receiving material A, B, C, and an outlet (37, 38; 47, 48; 61, 62,... Agent: Capitol City Techlaw, PLLC

20100311156 - Production of bio-based materials using photobioreactors with binary cultures: A method, device and system for producing preselected products, (either finished products or preselected intermediary products) from biobased precursors or CO2 and/or bicarbonate. The principal features of the present invention include a method wherein a binary culture is incubated with a biobased precursor in a closed system to transform at... Agent: Battelle Memorial Institute Attn:IPServices, K1-53

20100311157 - Systems and methods for production of biofuel: Self-sustaining, self-contained systems and methods for producing biofuels and for producing biofuel feedstock from algae. The system is carbon neutral or may be carbon positive, fixing more carbon than it releases to the atmosphere. In various embodiments, the system may be coupled to an existing carbon dioxide producing process to... Agent: Bell & Associates

20100311158 - Device and system for culturing cells and method of culturing cells using the same: The present invention provides a device for culturing cells. The device includes a well and a membrane. The well has an internal space and a membrane actuating control channel. The internal space has an inlet and an outlet. The membrane is provided between the membrane actuating control channel and the... Agent: Blakely Sokoloff Taylor & Zafman LLP

20100311159 - Methods for purifying or depleting molecules or cells of interest: e

20100311160 - Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom: Provided are processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, such as PER.C6® cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant... Agent: Traskbritt, P.C.

20100311161 - Method for tissue regeneration: The invention relates to DNA-sequences, their use and the use of DNA-sequences of the MAG gene or genes encoding the high mobility group proteins, agents for the treatment of various diseases including tumors, influencing the development of the vascular system, as well as for contraception and tissue regeneration, and appropriate... Agent: Knobbe Martens Olson & Bear LLP

20100311162 - Mammalian cell lines for increasing longevity and protein yield from a cell culture: Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene,... Agent: Immunomedics, Inc.

20100311163 - Cell transformed by human wnt3a gene: Disclosed is a cell transformed by a vector containing human Wnt3a gene, wherein the cell is selected from a group consisting of hair follicle-derived cells and prostate cancer-derived cells.... Agent: Foley And Lardner LLP Suite 500

20100311164 - Methods and compositions for feeder-free pluripotent stem cell media containing human serum: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component... Agent: The Law Office Of Jane K. Babin Professional Corporation

20100311165 - Device for collection and preservation of tissue or stool samples: An arrangement for collecting a tissue or stool sample has a sample vial and a source of preservative fluid. A fluid valve controls a flow of the preservative fluid from the source of preservative fluid to the sample vial. An air equalization vent tube is coupled to the source of... Agent: Raphael A Monsanto Rohm & Monsanto

20100311167 - Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures: Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized gas-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making... Agent: Davis Wright Tremaine, LLP/seattle

20100311166 - Method of improving cell proliferation of pancreatic progenitor cells in a pancreatic cell culture: The invention relates to the discovery that the proliferation and survival of pancreatic progenitor cells can be enhanced by contacting the cells with, (1) a caspase inhibitor sufficient to reduce apoptosis in the pancreatic endocrine cells; and, (2) a growth factor in an amount sufficient to increase the level of... Agent: Morrison & Foerster LLP

20100311168 - Nanoparticle mediated delivery of sequence specific nucleases: Provided are methods for introducing a sequence specific nuclease into a plant cell comprising a cell wall. Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall.... Agent: Traskbritt, P.C./dow Agrosciences

20100311169 - Methods of generating high-production of antibodies from hybridomas created by in vitro immunization: The invention provides methods for generating high titers of high-affinity antibodies from hybridoma cells produced by fusing myeloma cells with in vitro immunized donor cells. The hybridoma cells or mammalian expression cells with cloned antibody genes from the hybridomas producing the high-affinity antibodies may be mismatch repair defective due to... Agent: Woodcock Washburn LLP

20100311170 - Method for reprogramming differentiated cells: The present invention discloses a method for reprogramming a differentiated cell to an undifferentiated stem cell comprising fusing a pluripotent cell with a differentiated cell to form a fused cell, wherein the pluripotent cell is pre-treated or the fused cell is treated with a suitable amount of a Wnt/β-catenin pathway... Agent: Lucas & Mercanti, LLP

20100311171 - Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same: Stem cell reprogramming genes cloned into a single sustained expression-type Sendai viral vector are shown to reprogram differentiated somatic cells into induced pluripotent stem (iPS) cells without integration of vector sequences into the host cell's genome. The genes are transduced into normal differentiated somatic cells via infection with recombinant Sendai... Agent: Sughrue Mion, PLLC

20100311172 - Packaging cells for recombinant adenovirus: In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. Provided are means and methods for reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods... Agent: Traskbritt, P.C.

  
12/02/2010 > patent applications in patent subcategories. patent applications/inventions, industry category

20100304352 - Systems and methods for preserving a human organ for transplantation: A perfusion pump system for providing perfusate to an organ of a human body includes an actuator coupled to a pump to provide an actuating force to the pump. The pump includes an outlet for providing a perfusate to an organ coupled to the pump and an inlet for receiving... Agent: Heslin Rothenberg Farley & Mesiti PC

20100304354 - Methods for seperating frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations: Devices, compositions, and methods for handling, separating, packaging, and utilization of spermatozoa (1) that can be derived from previously frozen sperm samples collected from a male mammal. Specifically, techniques to uniformily stain (2) spermatozoal DNA even when derived from previously frozen sperm and separation techniques to separate and isolate spermatozoa... Agent: Inguran LLC

20100304353 - Methods of improving a genomic marker index of dairy animals and products: The present invention provides methods for improving desirable dairy traits through the use of a genomic marker index. Also provided are methods for determining an animal's genotype with respect to multiple markers used in calculation of the genomic marker index. The invention also provides methods for selecting or allocating animals... Agent: Pfizer Inc Mary J Hosley

20100304356 - Assembly and a method for in situ processing of waste: The invention relates to a device and a method for the in situ processing of waste, in particular for cleaning up a waste disposal site. The device comprises a sorting device with a set of processing devices connected downstream of said device. This set of processing devices comprises a fermenting... Agent: Fliesler Meyer LLP

20100304355 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100304357 - Universal drinking adapter for beverage bottles, and devices and kits for determining small molecules, metal ions, endotoxins, and bacteria, and methods of use thereof: Certain features, aspects, examples and embodiments described herein relate to adapters for securing drinking apparatuses for individuals of all ages (infants, children, adults, and seniors) such as nipples, sippers, and straws, to commercially available beverage containers to aid in the consumption of the contained liquid. Other features, aspects, examples and... Agent: Lando & Anastasi, LLP

20100304364 - Compositions and methods for monosynaptic transport: Disclosed herein are methods of expressing a heterologous nucleic acid sequence, such as a sequence encoding a detectable protein, in a primary neuron (or plurality of primary neurons) and other neurons that are monosynaptically connected to the primary neuron (or plurality of primary neurons). Such methods involve viruses (such as,... Agent: Klarquist Sparkman, LLP

20100304360 - Gold nanoparticle hpv genotyping system and assay: The invention provides oligonucleotides, kits and methods for genotyping HPV.... Agent: Gregory T. Pletta Nanosphere, Inc.

20100304361 - Method and device for monitoring a therapeutic treatment regime: A method for monitoring a therapeutic treatment regime in an individual having a disease, comprises: providing at a first location a solid substrate capable of immobilising a biomarker characteristic of the disease and a therapeutic compound in the biological sample, contacting the biological sample with the solid substrate to immobilise... Agent: Dinsmore & Shohl LLP

20100304358 - Methods of identifying biological targets and instrumentation to identify biological targets: Methods of measuring and/or detecting biological targets, methods of distinguishing among the same type of biological target, single-molecule detection systems, fluorescent/biological target complexes, methods of using fluorescent/biological target complexes, and the like are disclosed.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100304359 - Multianalyte assay: The invention provides compositions, systems and methods for detecting multiple analytes from a sample.... Agent: Cooley LLP Attn: Patent Group

20100304362 - New detection method for cervical hpvs: The invention describes a consensus PCR based method (i.e. HRE7-PCR) for the simultaneous detection of 14 Human Papilloma Virus types (i.e. HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) that are classified as (probably) high-risk, relating to the causation of cervical cancer)... Agent: Morrison & Foerster LLP

20100304363 - Peptide compounds for detecting or inhibiting sars coronavirus and application thereof: Disclosed herein are peptide compounds and the application thereof to the detection and inhibition of SARS coronavirus. Composed of dipeptides, the compounds for detecting and inhibiting SARS coronavirus can be readily synthesized and produced at low cost. In addition, they can be stored safely for a long period of time.... Agent: Staas & Halsey LLP

20100304396 - Animal health diagnostics: A physical blood sample of animal is sent to a satellite laboratory facility. The blood sample is pre-processed into sub-samples of the sample and the sub-samples are coded. The coded blood sub-samples are physically carried to the main laboratory for analysis. The satellite facility electronically inputs a request for a... Agent: Greenberg Traurig LLP (la)

20100304385 - Assay: The invention provides a LAMP assay for detection of meningococcal disease, the test comprising at least one nucleic acid primer set capable of detecting Neisseria meningitides in a LAMP based molecular test, the primer set being chosen from the primer sets listed in Table 1 as LAMP SETS 1 to... Agent: Scully Scott Murphy & Presser, PC

20100304388 - Biomarker for successful aging without cognitive decline: Methods and compositions for determining whether a subject will age without developing cognitive decline are provided. An exemplary method includes detecting one or more allelic variants in a gene encoding low density lipoprotein-related protein 1B. In a preferred embodiment, the detecting step is accomplished by contacting a sample obtained from... Agent: Pabst Patent Group LLP

20100304383 - Biomarkers for prenatal diagnosis of congenital cytomegalovirus: The invention provides compositions and methods useful for early detection of congenital CMV infection, predicting the likelihood and severity of congenital CMV disease, and monitoring the efficacy of therapeutic approaches. Compositions of the present invention include biomarkers that are differentially expressed in CMV-infected mothers and fetuses compared to uninfected individuals.... Agent: Townsend And Townsend And Crew, LLP

20100304368 - Components and method for enzymatic synthesis of nucleic acids: Novel methods for enzymatic synthesis of nucleic acid chains and the substrates for the same are disclosed. The methods are based on a step-wise enzymatic reaction. The sequencing of nucleic acids is an example of the use of the claimed methods.... Agent: Mcdermott Will & Emery LLP

20100304371 - Compositions and methods for detecting mycobacteria: The present invention features compositions and methods that can be used to analyze samples for the presence of mycobacterium from MTC, M. bovis and M. tuberculosis. Moreover, the methods can be used, for example, to differentiate M. bovis from M. tuberculosis and other MTC specimens. The compositions include oligonucleotides that... Agent: Fish & Richardson PC

20100304367 - Compositions for real-time, single molecule sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Life Technologies Corporation C/o Intellevate

20100304386 - Enzymes for amplification and copying bisulphite modified nucleic acids: The invention relates to the use of enzymes for copying or amplifying bisulphite modified or treated nucleic acids, wherein the enzymes are more effective in copying or amplifying the nucleic acid compared with native Taq polymerase under substantially the same conditions.... Agent: Knobbe Martens Olson & Bear LLP

20100304376 - Epigenetic silencing of cyclooxygenase-2 affects clinical outcome in gastric cancer: The present invention discloses methods of using the methylation status of the COX-2 gene promoter region as a biomarker for a gastric cancer patient to determine a prognosis and a treatment regimen, and to monitor the progress of a treatment regimen.... Agent: Perkins Coie LLP

20100304381 - Fluorescent nucleobase conjugates having anionic linkers: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate... Agent: Life Technologies Corporation C/o Intellevate

20100304382 - Gene defects and mutant alk kinase in human solid tumors: In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100304393 - Genetic predictors of international normalized ratio (inr) fluctuation with warfarin therapy: There are disclosed methods and kits for identifying a subject having genetic predictors of predisposition to abnormal international normalized ratio (INR) fluctuation during warfarin therapy. In an embodiment, a method includes testing the subject to check for a presence of a predetermined genetic variation. The predetermined genetic variation is correlated... Agent: Louis Tessier

20100304392 - Hepatitis b viral variants with reduced susceptibility to nucleoside analogs and uses thereof: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral... Agent: Baker Botts L.L.P.

20100304375 - Influenza virus genome replication and transcription system in yeast cells: A system in which vRNP purified from influenza virus particles is introduced into yeast (Saccharomyces cerevisiae) and the transcription and replication from the viral RNA genome are supported by the yeast. The virus genome replication, the virus gene transcription and the virus protein expression occurring in yeast cells in which... Agent: The Webb Law Firm, P.C.

20100304370 - Intracellular ph sensor using nucleic acid assemblies: Disclosed are nucleic acid-based sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The sensor includes an I-switch that is triggered by protons, and which functions as a FRET-based pH sensor inside living cells and organisms. Also disclosed are compositions and methods for measuring... Agent: Foley & Lardner LLP

20100304372 - Liver cancer methods and compositions: The present invention provides a novel method for detection of liver cancer. This method detects high-sensitively, high-specifically, simply and accurately liver cancer, especially that in early stage by identifying and/or quantifying methylation on particular genes and/or their DNA fragments in clinical specimens, and by combining said methylated DNA values with... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100304369 - Method and apparatus for diagnosing age-related macular degeneration: Disclosed is a method for identifying an individual who has an altered risk for developing age-related macular degeneration comprising detecting an insertion/deletion polymorphism in the ARMS2 gene... Agent: David S. Resnick

20100304378 - Method for detecting or quantifying a truncating mutation: The present invention discloses a new method for detecting or quantifying a truncating mutation of a target gene in a subject, said method relying on the in vitro compartmentalization of single genetic constructs in aqueous droplets of a water-in-oil emulsion.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100304377 - Method of detecting norovirus rna: The amount of an RNA transcription product amplified in an RNA amplification process is measured using a nucleic acid probe labeled with an intercalating fluorescent dye. The RNA amplification process comprises the steps of using at least two sets of primer pairs comprising a first primer and a second primer... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100304384 - Method of identifying compounds that induce or inhibit endoplasmic reticulum stress or oxidative stress: The present invention generally relates to a method for the identification of compounds for the treatment of neurodegenerative diseases. Said method is based on a cell model for neurodegeneration useful for the identification of potentially useful compounds for the treatment or the prevention of a neurodegenerative disease associated with deficient... Agent: Moore & Van Allen PLLC

20100304395 - Method, program, and system for normalizing gene expression amounts: The present invention aims at presenting novel means for analyzing and correcting gene expression amounts. There is provided a gene expression amount normalizing method in which the number of cells in a sample is obtained by measuring a repeated sequence present in a substantially fixed proportion in a genome contained... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100304387 - Methods and compositions for signal enhancement using multivalent interactions: Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for an analyte, using an amplification polymer that multivalently binds to one or more non-analyte-specific binding site of the multivalent bridge conjugate, if present on the solid support.... Agent: Brinks Hofer Gilson & Lione/utah Utah Office

20100304374 - Methods and tools for discriminating colorectal adenomas and adenocarcinomas: The present invention relates to the differential expression of genes in colorectal adenoma and adenocarcinoma cells and their correlation with chromosomal aberrations. The present invention provides tools for detecting chromosomal aberrations linked to progression of adenomas into adenocarcinoma cells. The present invention discloses methods and tools for in vivo and... Agent: Philips Intellectual Property & Standards

20100304373 - Methods for assessing the susceptibility of a human to diminished health and wellness: The present invention relates to methods for assessing the advisability that a human should employ a compensatory composition comprised of one or more antioxidant ingredients. The methods involve assessing occurrence in the human's genome of a plurality of certain polymorphisms. Methods for determining the composition of preferred compensatory compositions are... Agent: Robert P. Ricciardi Suite 200

20100304391 - Methods for assessment and treatment of depression via utilization of single nucleotide polymorphisms analysis: Described herein are assays, kits and methods for treating depression, including the diagnosis and treatment of depression based on the determination of genetic predispositions towards inhibition or enhancement of Ca2+/calmodulin-dependent protein kinase II (CaMKII). For example, described herein are methods and kits (including assays) for determining if one or more... Agent: Shay Glenn LLP

20100304390 - Methods for detecting gene dysregulations: Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g. translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5′ and 3′ regions of the gene.... Agent: Foley & Lardner LLP

20100304366 - Methods for determining virulence and invasiveness among various staphylococcus aureus strains: This invention describes quick diagnostic methods to distinguish CA-MRSA MW2 or CA-MRSA USA300 strains in clinical samples from various sources. Fluorescent labeled primers which amplify 1) two unique agr sequences from each strain, 2) a partial spa gene and 3) a partial pvl gene are packaged into a multiplex PCR... Agent: Lu & Associates, P.C.

20100304365 - Mutation of prps1 gene causing cmtx5 disease and the use thereof: Disclosed is a gene mutation associated with peripheral neuropathy associated with sensorineural hearing loss and optic neuropathy. More specifically, disclosed are: a polynucleotide comprising a mutation associated with peripheral neuropathy associated with sensorineural hearing loss and optic neuropathy, or a complementary polynucleotide thereof; a polynucleotide which hybridizes with said polynucleotide;... Agent: Harness, Dickey & Pierce, P.L.C

20100304389 - Preparation and isolation of 5' capped mrna: The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool for identifying RNA-protein interactions. Such capped RNA finds use... Agent: Life Technologies Corporation C/o Intellevate

20100304380 - Quantitative dna methylation imaging of cells and tissues: We describe an image-cytometrical tool performing rapid cell-by-cell assay to analyze the impact of environmental conditions on global DNA methylation, including alterations of methylcytosine load and the spatial reorganization of methylated DNA in cell nuclei. The assay can be combined with molecular approaches for profiling of cells and their genomes.... Agent: Jian Tajbakhsh

20100304394 - Screening methods involving the detection of short-lived proteins: A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter protein and a protein encoded by a sequence from a cDNA library derived from a sample of cells, the sequence... Agent: Quine Intellectual Property Law Group, P.C.

20100304379 - Spores for the stabilization and on-site application of bacterial whole-cell biosensing systems: The presently-disclosed subject matter is directed to biosensors comprising spore-forming bacterial cells and/or spores generated therefrom, a recognition unit within each spore-forming cell for binding an analyte of interest, and a reporter molecule within each spore-forming cell for detecting binding of the analyte of interest, wherein the reporter molecule generates... Agent: Stites & Harbison PLLC

20100304398 - novel diagnostic sensor for rapid and reproducible ro52 protein domain detection: The present invention relates to the use of specific synthetic sensor molecules for the discrimination of proteins and protein domains involved in autoimmunity. More specifically, in one embodiment, the invention relates to the detection of antibodies which bind to specific domains of the Ro52 protein. In another embodiment, the invention... Agent: Darby & Darby P.C.

20100304397 - Chromogenic test kit for detecting health conditions in saliva: A device and method for detecting diseases, disorders and health conditions in saliva or other body fluid. The method employs solid phase immunoassay and similar detecting processes along with one of several bioluminescent reactions such that the presence of specific biomarkers is reported visually on a chromogenic panel incorporated directly... Agent: Christopher Burns

20100304400 - Distinguishing assay: The current invention comprises a method for determining of an antibody against a drug antibody in a sample using an immunoassay comprising a capture drug antibody and a tracer drug antibody, wherein the method comprises providing i) a capture drug antibody, which is the drug antibody conjugated to a solid... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100304399 - Method for continuously detecting glucose concentration in sample, kit thereof and method for using biosensor: The invention provides a method for continuously detecting glucose concentration in a sample, including: (a) providing a biosensor comprising a transducer and a polysaccharide covered on the surface of the transducer; (b) providing a carbohydrate binding protein solution, wherein the carbohydrate binding protein has at least one receptor, and the... Agent: Pai Patent & Trademark Law Firm

20100304401 - Ys68 gene involved in primitive hematopoiesis: A novel gene, dubbed “YS68”, involved in primitive hematopoiesis was successfully isolated from cDNA derived from mouse yolk sacs. In addition, a human gene corresponding to this gene was successfully isolated. Expression characteristics of these genes suggested their involvement in primitive hematopoiesis. The proteins of this invention and genes encoding... Agent: Fish & Richardson PC

20100304403 - Multiplex assay methods and compositions: Luminescence assays and compositions for assay of biomolecular interaction and activity and detection of modulators of biomolecular interaction and activity are provided. Technology described herein has utility in a variety of assay formats and types, for example, simultaneous monitoring multiple parameters which affect interaction and activity of biological molecules. Compositions... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20100304402 - Chimeric human sweet-umami and umami-sweet taste receptors: This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable... Agent: Hunton & Williams LLP Intellectual Property Department

20100304406 - Protein phosphorylation by serine/threonine kinases in insulin signaling pathways: The invention discloses 137 novel phosphorylation sites identified in insulin signaling pathways, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Nancy Chiu Wilker, Ph.d., Esq. Chief Intellectual Property Counsel

20100304405 - Combinatorial discovery of enzymes with utility in biomass transformation: Methods for the cell-free identification of polypeptide and polypeptide combinations with utility in biomass transformation, as well as specific novel polypeptides and cell-free systems containing polypeptide combinations discovered by such methods are disclosed.... Agent: Quarles & Brady LLP

20100304404 - Molecular modification assays: Systems for detecting molecular modifications and the presence and/or activity of enzymes and/or other agents involved in facilitating or otherwise regulating such modifications.... Agent: Kolisch Hartwell, P.C.

20100304407 - Fluorescence lifetime and fluorescence assays: The invention provides a method for determining a degree of phosphorylation of a substrate, for example a peptide substrate, using a fluorescence probe that acts alone or with another material and has a lifetime that varies when in proximity to a phosphate, the method comprising: causing the fluorescence probe to... Agent: Myers Bigel Sibley & Sajovec

20100304411 - Endogenous morphine or a naturally occurring metabolite thereof as a marker for infection: The invention relates to a method for detecting infection in a patient comprising measuring the concentration of endogenous morphine or a naturally occurring metabolite thereof in a biological sample obtained from said patient.... Agent: Mcandrews Held & Malloy, Ltd

20100304409 - Method for detecting premature senescence in tumor cells and a kit for detecting premature senescence in tumor cells: The present invention provides a method for detecting senescence in tumor cells and a kit for detecting senescence in tumor cells. eEF1A1 and CD markers are provided, wherein changes in the levels of the markers are correlated with premature senescence of tumor cells.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100304410 - Method of assessing colorectal cancer status in an individual: The invention relates to a method of screening a patient to identify and quantify risk of colorectal cancer, and thereby identify patients suitable for further invasive investigation such as a colonoscopy. The method employs auto-antibodies that are shown to correlate with colorectal cancer risk method and involves of assaying a... Agent: David S. Resnick

20100304412 - Methods for determining the risk of prenatal complications: The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits... Agent: Fish & Richardson P.C.

20100304408 - Use of the alpha chain of brain spectrin and fragments thereof, for diagnosing cerebral diseases: The present invention pertains to a method for in vitro prognosticating and/or diagnosing cerebral cerebral malaria, wherein said method comprises a step of detecting non-erythroid spectrin or fragments thereof, and/or antibodies directed against non-erythroid spectrin, in a biological sample. Reagents and kits for performing this method are also disclosed.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100304413 - Diagnostic use of individual molecular forms of a biomarker: Methods are provided of diagnosing, monitoring or determining the severity of disease or injury by measuring individual molecular forms of neutrophil gelatinase-associated lipocalin (NGAL) in bodily fluids, including the diagnosis and monitoring of acute renal injury leading to acute renal failure in a human or mammalian subject by determining the... Agent: Clark & Elbing LLP

20100304414 - Methods and devices for detecting methicillin resistant staphylococcus aureus: Provided are methods and devices for detecting methicillin-resistant Staphylcoccus aureus.... Agent: Foley Hoag, LLP (w/isa) Patent Group

20100304415 - Chromatography of metal complexes: A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the... Agent: Bryan Cave LLP

20100304416 - Prostaglandin e2 modulation and uses thereof: Methods, uses, kits and products are described for the prognosis, diagnosis, prevention and treatment of myotronic dystrophy type 1 (DM1), and more particularly for the prognosis, diagnosis, prevention and treatment of the congenital form of myotronic dystrophy type 1 (cDM1), based on changes in/modulation of prostaglandin E2 (PGE2).... Agent: Goudreau Gage Dubuc

20100304417 - Markers for transformed epithelium and potential targets for therapy of cancer of the gingivo buccal complex: Systematic comparisons of samples of adjacent clinically non malignant and tumor tissue from cancer of the gingivo buccal complex obtained during surgical resection of the tumor revealed significant differences in protein expression between the cancer tissue and the adjacent clinically non malignant tissue in each patient. This study has identified... Agent: Ladas & Parry LLP

20100304418 - Compositions and methods for monitoring flow through fluid conducting and containment systems: Latently detectable tracers for use in fluid conducting and containment systems wherein the interaction between the tracer and a biomacromolecule produces a detectable signal. More specifically, the latently detectable tracers monitor flow through such systems. Methods for monitoring the flow of fluid using the tracers, and a kit for use... Agent: Ostrager Chong Flaherty & Broitman PC

20100304426 - Analytical methods for measuring synthetic progesterone: Embodiments relating to methods, processes and systems for measuring progesterone are provided. In particular, methods permit measurement and quantification of synthetic and/or endogenous progesterone from a progesterone-containing blood fluid sample by measuring a progesterone carbon isotope ratio by mass spectrometry and calculating the fraction of synthetic progesterone in the sample... Agent: Greenlee Sullivan P.C.

20100304420 - Bioreactor for mesophilic and/or thermophilic fermentation: This invention relates to a bioreactor for producing high rates of hydrogen from plant biomass. It also relates to the rapid screening, selection and isolation of biofilm forming mesophilic and/or thermophilic bacteria or bacteria consortia that generate high levels of hydrogen from plant biomass or from soluble hydrolysates derived from... Agent: Nixon Peabody, LLP

20100304428 - Cell holding method, cell testing method and cell handling apparatus: It is intended to provide a method for individually arranging and holding, with rapidity and few variations, the number of cells required for bioassay. The present invention provides a cell holding method including: preparing a sheet provided with a plurality of through-holes; and bringing a suspension liquid of cell-supported particles... Agent: Canon U.s.a. Inc. Intellectual Property Division

20100304423 - Cell measuring vessel, extracellular potential measuring method, and chemical testing method: The cell observation using a conventional well plate takes much costs. Each well 3 being opened at a top plate 2a of the well plate 1 has a diameter reduced portion 32 which inner circumferential surface 32a is conically hollowed. At a lower portion of the diameter reduced portion 32... Agent: Marlana Titus

20100304424 - Diagnostic and therapeutic tools for diseases altering vascular function: The invention relates to diagnostic and therapeutic tools and applications, particularly useful in diseases that affect vascular health and in inflammatory diseases. In particular, said diagnostic and therapeutic tools employ suitable detection or modulation of endothelial glycocalyx.... Agent: Traskbritt, P.C.

20100304422 - In-vitro model of the transformation of metaplasia to neoplasia: This invention relates to a novel in-vitro model of transformation of a benign Barrett's cell line to a neoplastic cell line following repeated exposure to acid and bile over the course of about 65 wks, and to the process of using the model to study the transformation.... Agent: University Of Medicine And Dentistry Of New Jersey Office Of Patents And Licensing

20100304419 - Method for determining the prognosis of gastric cancer: The 14-3-3β protein is used herein as a tumor marker for prognosis in gastric cancer. The method comprises steps of providing a biological sample, qualifying the 14-3-3β protein level in the sample, and comparing the 14-3-3β protein level in the sample with a normal sample. Upon the 14-3-3β protein level... Agent: Wpat, PC Intellectual Property Attorneys

20100304425 - Method for the ex vivo analysis of a cell and apparatus therefore: The invention provides a method for ex vivo analysis of a cell (100). The method includes penetrating the cell membrane (110) of the cell (100) with a first nano electrode (10) and a plurality of second nano electrodes (20, 20′, 20″, . . . ), wherein the first nano electrode... Agent: Kenyon & Kenyon LLP

20100304421 - Optical monitoring method: A mixture of dyes each having an optical property (e.g. fluorescence intensity) which is sensitive to an external factor is caused to interact with a system that is to be monitored, such that the system provides the external factor and therefore influences the optical properties of the dyes. The optical... Agent: Stites & Harbison PLLC

20100304427 - Substrates for adhering, culturing and assaying cells: The present invention provides substrates useful for culturing cells under low serum or serum free conditions. The substrates are useful for conducting cell-based assays where there is interference from serum proteins. Methods are also provided for using the substrates of the present invention as well as methods for making the... Agent: Corning Incorporated

20100304429 - Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging... Agent: O''melveny & Myers LLP Ip&t Calendar Department La-13-a7

20100304430 - Methods for generating analogs of coenzyme a: Methods to generate analogs of coenzyme A in vivo are disclosed. The methods to generate analogs of coenzyme A in a cell comprise reacting pantetheine or a derivative thereof with a reporter to form labeled pantetheine or a derivative thereof, contacting the cell with the labeled pantetheine or derivative thereof... Agent: Fenwick & West LLP

20100304435 - Fluorescent proteins, their production and use: The present invention provides variants of fluorescent proteins, which are improved with regard to their properties for use as reporter proteins and/or in analytics. In particular, variants of fluorescent proteins are provided, which fluoresce brighter, show improved quantum yield and/or have shifted excitation or emission spectra. The fluorescent proteins according... Agent: Senniger Powers LLP

20100304432 - Genetically modified biological cells: The present invention is based, in part, on our discovery of a way to configure expression cassettes so that the expression of a selectable marker protein, which is critical for the growth or survival of a cell, also results in the expression of a protein of interest in a biological... Agent: Goodwin Procter LLP Patent Administrator

20100304434 - Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes, Inc.

20100304433 - Polypeptides having protease activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes North America, Inc.

20100304431 - Trna synthesis method, nucleic acid, aminoacyl trna synthesis method, and process for production of protein introduced with unnatural amino acid: The present invention relates to a process for producing a protein having an unnatural amino acid introduced therein, the process including: expressing in a eukaryotic cell an aminoacyl-tRNA synthetase, a nucleic acid having a sequence containing a eukaryote-derived tRNA nucleotide sequence linked to the 5′ end of a tRNA nucleotide... Agent: Ostrolenk Faber Gerb & Soffen

20100304436 - Fucosylation-deficient cells: An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a combination thereof is provided. Cells having a gene encoding a modified FX protein are... Agent: Regeneron Pharmaceuticals, Inc

20100304437 - Methods for enhancing the degradation or conversion of cellulosic material: The present invention relates to methods for degrading or converting a cellulosic material, comprising: treating the cellulosic material with an enzyme composition in the presence of a polypeptide having cellulolytic enhancing activity.... Agent: Novozymes, Inc.

20100304438 - Novel beta-glucosidase enzymes: Provided are modified beta-glucosidase enzymes, derived from the Trichoderma reesei Cel3A beta-glucosidase, that exhibit improvements in one or more kinetic parameters (KG, KG2, kcat) comprising amino acid substitutions at one or more of positions 43, 101, 260 and 543. Also provided are genetic constructs comprising nucleotide sequences encoding for modified... Agent: Fitzpatrick Cella Harper & Scinto

20100304439 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy or sugary materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent: Xyleco, Inc. Celia Leber

20100304440 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy or sugary materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent: Xyleco, Inc. Celia Leber

20100304441 - Fungal strains and a process for production of insecticide thereof: The present invention relates to fungal strains capable of producing insecticide and a process for production of insecticide. It also relates to a method of cultivation of fungal strains and a fermentation medium for culturing the fungal strains.... Agent: Patent Docket Clerk Cowan, Liebowitz & Latman, P.C.

20100304444 - Method of amplification: The present invention relates generally to a method of amplifying a nucleic acid region of interest and, more particularly, to a method of amplifying a nucleic acid region of interest via a nested single tube PCR. The method of the invention is designed to provide a means to selectively inactivate... Agent: Knobbe Martens Olson & Bear LLP

20100304442 - Methods, compositions and kits for the improved detection of small rna molecules: The present invention provides compositions, methods and kits for use in the detection of small RNA sequences, which allow for rapid and robust amplification and detection. The methods provide improved sensitivity and efficiency in the amplification-based detection of small RNA sequences by incorporating one or more base-modified duplex-stabilizing dNTPs during... Agent: Seed Intellectual Property Law Group PLLC

20100304443 - Sampling device: The present invention generally relates to devices, systems, and methods for acquiring and/or dispensing a sample without introducing a gas into a microfluidic system, such as a liquid bridge system. An exemplary embodiment provides a sampling device including an outer sheath; a plurality of tubes within the sheath, in which... Agent: Kilyk & Bowersox, P.l.l.c.

20100304446 - Devices, systems, and methods for amplifying nucleic acids: The present invention generally relates to a devices, systems, and methods for amplifying nucleic acids in flowing droplets. In certain embodiments, the invention provides a device for amplifying nucleic acids including at least one channel through which sample droplets including nucleic acids flow, in which the nucleic acids in the... Agent: Kilyk & Bowersox, P.l.l.c.

20100304445 - Nucleic acid packaging system: The present invention relates to cloning target nucleic acids using phage packaging mechanisms. Packaging initiation sites may be introduced into the target DNA. Components of a phage packaging system may be combined with the target DNA to package the DNA into phage capsids. The packaged DNA may be used to... Agent: Polsinelli Shughart PC

20100304447 - Paired-end reads in sequencing by synthesis: The disclosure provides methods of generating paired reads in sequencing-by-synthesis process, particularly, in systems with relatively short read lengths (e.g., 15-35 bases), such as for example, in single molecule sequencing by synthesis. Several implementations of the methods are provided. Of particular advantage are the methods that permit re-sequencing of the... Agent: Brown Rudnick LLP

20100304448 - Method for the enzymatic reduction of alpha- and beta-dehydroamino acids using enoate reductases: e

20100304449 - Method for obtaining products containing different concentrations of compounds produced by fermentation: The invention relates to a method for producing different products comprising a target substance, particularly amino acids or vitamins, wherein the target substance is produced by fermentation.... Agent: Smith, Gambrell & Russell

20100304450 - Microbial production of pyruvate and pyruvate derivatives: Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a carbon sources.... Agent: Mueting, Raasch & Gebhardt, P.A.

20100304451 - Process for the preparation of an enantiomerically and/or diastereomerically enriched ester, thioester, alcohol or thiol: The invention relates to a process for preparing an enantiomerically and/or diastereomerically enriched ester or thioester having at least two adjacent chiral centres, wherein a mixture of stereoisomers of a secondary alcohol or thiol having a structure comprising a first chiral center forming a secondary alcohol or secondary thiol moiety... Agent: Nixon & Vanderhye, PC

20100304452 - Process of producing oil from algae using biological rupturing: A process for production of biofuels from algae can include cultivating an oil-producing algae, extracting the algal oil, and converting the algal oil to form biodiesel. Extracting the algal oil from the oil-producing algae can include biologically rupturing cell wall and oil vesicles of the oil-producing algae using at least... Agent: Thorpe North & Western, LLP.

20100304453 - Microorganisms and methods for conversion of syngas and other carbon sources to useful products: A non-naturally occurring microbial organism having an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway includes at least one exogenous nucleic acid encoding an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway enzyme expressed in a sufficient amount to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol. The aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol.... Agent: Mcdermott, Will & Emery LLP

20100304454 - Novel arabinose-fermenting eukaryotic cells: The present invention relates to eukaryotic cells which have the ability to convert L-arabinose into D-xylulose 5-phosphate. The cells have acquired this ability by transformation with nucleotide sequences coding for an arabinose isomerase, a ribulokinase, and a ribulose-5-P-4-epimerase from a bacterium that belongs to a Clavibacter, Arthrobacter or Gramella genus.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100304455 - Ethanol producing process and apparatus: The present invention relates to a process for producing ethanol by carrying out the following steps: performing enzymatic saccharification of pre-treated lignocellulosic biomass in a reaction system; performing ethanol fermentation of fermentable sugars obtained from the saccharified pre-treated lignocellulosic biomass in the same reaction zone as the enzymatic saccharification; distilling... Agent: Morrison & Foerster LLP

20100304456 - Continuous-batch hybrid process for production of oil and other useful products from photosynthetic microbes: A process for cultivating photosynthetic microbes comprising Closed Systems for continuous cultivation and Open Systems for batch cultivation, in which (a) the Closed System Area occupies no more than 20% of the Total Land Area of the cultivation facility; (b) batch cultures in the Open Systems are initiated with an... Agent: Martin E. Hsia Cades Schutte A Limited Liability Law

20100304457 - Method for producing biogas in controlled concentrations of trace elements: p

20100304458 - Hydrogen and electrical current production from photosynthetically driven semi biological devices (sbds): The present invention provides a device comprising a first chamber and a second chamber, the first chamber oriented in two alternative ways (1) the first chamber having an anode in contact with an aqueous solution comprising a photosynthetic organism or photosynthetic part thereof and an electron acceptor molecule, an inlet... Agent: Pepper Hamilton LLP

20100304459 - Glucose dehydrogenase polypeptides and related polynucleotides: The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase polypeptide. In addition, the present invention is directed to a polynucleotide that encodes for the GDH polypeptides of the present invention, to nucleic acid sequences comprising... Agent: Dechert, LLP

20100304460 - Novel beta-galactoside-alpha2, 6-sialyltransferase, a gene encoding thereof, and a method for producing thereof: The present invention provides a novel β-galactoside-α2,6-sialyltransferase having high productivity and/or high activity, and a nucleic acid encoding the sialyltransferase. The present invention also provides a microorganism producing the sialyltransferase. The present invention further provides a vector carrying a nucleic acid encoding the sialyltransferase, and a host cell transformed with... Agent: Birch Stewart Kolasch & Birch

20100304461 - Portable, temperature and chemically inducible expression vector for high cell density expression of heterologous genes in escherichia coli: The present disclosure relates to nucleic acids comprising a sequence of SEQ ID NO: 1. The nucleic acid may be an isolated DNA and/or may be in the form of a plasmid or an expression vector. It may also be comprised in a microorganism. The nucleic acid may further comprise... Agent: Baker Botts L.L.P. Patent Department

20100304462 - Synthetic binding proteins: Methods and compositions are provided for creating a binding protein that recognizes a rationally chosen recognition sequence in which a first amino acid has been substituted for a second amino acid using site-directed mutagenesis of a member protein of a set of proteins at an identified position or positions correlated... Agent: Harriet M. Strimpel, D. Phil.

20100304463 - Ribonuclease in which an amino acid sequence of a known ribonuclease is preceded by a residue at the n-terminus, and a method of making it recombinantly: A new RNase, and a method for making it, are disclosed. The RNase has an amino acid sequence that is disclosed in U.S. Pat. No. 6,239,257 B1, but that is preceded by a different N-terminus residue.... Agent: Mark H. Jay, P.A.

20100304464 - Stable, functional chimeric cellobiohydrolases: The present disclosure relates to CBH II chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100304465 - Recombinantly modified plasmin: Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.... Agent: Womble Carlyle Sandridge & Rice, PLLC

20100304466 - System for supplying an automatic inoculating device and process using such an automatic device: A supplying system for an automatic inoculating machine for a sample on a substrate, characterized in that it includes a turret mobile in rotation, preferably around an axis substantially vertical, and an arm mobile in rotation, preferably around an axis substantially horizontal, carried by the turret, at a distal end... Agent: Thomas P O'connell

20100304467 - Methods for producing human ceramide using yeast transformants: s

20100304468 - Method for introducing nucleic acids into fungal cells: The method disclosed herein, relates generally to introducing molecules such as biomolecules (e.g., nucleic acids) into a filamentous fungus. More specifically, the methods disclosed herein relate to introducing one or more nucleic acids into a filamentous fungus.... Agent: Danisco US Inc. Attention: Legal Department

20100304469 - The method of degumming jute fibres with complex enzyme (2): A method of degumming jute fibres with complex enzyme, wherein said complex enzyme comprises pectinase and laccase, comprises the steps of: a. Soaking the jute fibres in said complex enzyme water solution, wherein the weight proportion of said complex enzyme water solution and jute fibres ranges from 12:1 to 40:1;... Agent: Schwegman, Lundberg & Woessner, P.A.

20100304471 - Assay: The present invention relates to test devices, and in particular devices capable of detecting the presence or absence of an analyte in a sample, such as a liquid sample. Also provided are methods of using such devices for quantitative or qualitative measurement of one or more analytes in a liquid... Agent: Dla Piper LLP (us)

20100304470 - Microfluidic chip: A microfluidic chip including a substrate and at least a channel set is provided. The substrate has a surface, and the channel set is formed in the substrate and includes a channel, at a least a filler fillister, and at least a well fillister. The filler fillister and the well... Agent: Wpat, PC Intellectual Property Attorneys

20100304472 - Cell culture apparatus and mass automatic cell culture device having it: The present invention relates to a cell culture apparatus and a mass automatic cell culture device having it. There is provided a cell culture apparatus comprising a cylindrical cell culture flask which is air-tightly sealed to culture a cell using a culture solution and various gases and formed of a... Agent: Clark & Elbing LLP

20100304473 - cell culture flask and the cell culture device having it: The present invention relates to a cell culture flask for culturing a cell using a culture solution, particularly to a cell culture flask enabling to culture a cell without any contamination, to automatically introduce and discharge the culture solution or gases and to be stacked in turn, and a cell... Agent: Clark & Elbing LLP

20100304474 - Rotation driving device for cell culturing: The present invention relates to a rotation driving device for cell culturing, comprising: a power supplying unit operated by receiving an electric power from an outside; a rotational part rotated by the power supplying unit; and a driving part which is provided at an upper side of the rotational part... Agent: Clark & Elbing LLP

20100304475 - Device for collecting sample: Disclosed herein is a device for collecting a sample, which is intended to dispense a received sample onto a measurement strip. The device includes a main body and a pair of receiving pieces. The receiving pieces protrude from a first end of the main body in such a way as... Agent: Cantor Colburn LLP

20100304476 - Expression of human serum albumin in plastids: Human Serum Albumin (HSA) or an HSA fusion protein is expressed in plant plastids. A plastid transformation vector is made which contains an expression cassette that contains regulatory sequences, the coding region for HSA or an HSA fusion protein and a selectable marker coding sequence. The vector is used to... Agent: Timothy H. Van Dyke

20100304477 - Population of adult stem cells derived from cardiac adipose tissue and use thereof in cardiac regeneration: The present invention relates to the isolation and characterization of a novel population of adult stem cells derived from fatty heart tissue, which constitutively express GATA-4 and/or Cx43. Said cell population can be used in cell therapy protocols in order to regenerate damaged myocardial tissue.... Agent: Moore & Van Allen PLLC

20100304478 - Method for isolating renal stem/progenitor cells, renal stem/progenitor cells and therapeutic agent for renal disease: It is intended to provide a method for noninvasively isolating human renal stem/progenitor cells, an isolated renal stem/progenitor cells, a therapeutic agent for renal disease, mouse mesenchymal cells which can be used for isolating human renal stem/progenitor cells and a culture supernatant of the same. Renal stem/progenitor cells are isolated... Agent: Knobbe Martens Olson & Bear LLP

20100304480 - Hematopoietic fingerprints: methods of use: The present invention is related to the discovery that the detection of one or more biomarkers in a body sample can identify hematapoietic progenitors that are precursors to a specific blood cell lineage. The methods of the present invention are also directed to the detection of the dysregulation of these... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100304481 - Medium and culture of embryonic stem cells: Previous methods for culturing primate pluripotent stem cells have required either fibroblast feeder cells or a medium which was exposed to fibroblast feeder cells to maintain the stem cells in an undifferentiated state. It has now been found that high levels of fibroblast growth factor in a medium together with... Agent: Quarles & Brady LLP

20100304479 - Method of making a hair and biological material: A method of making a hair, including a step of culturing an undifferentiated cell of a mammal to produce an embryoid body and a step of further culturing the embryoid body is provided, wherein the culturing step is to culture the embryoid body on a three-dimensional matrix for 5 to... Agent: Ladas & Parry LLP

20100304482 - Swellable synthetic microcarriers for culturing cells: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide... Agent: Corning Incorporated

20100304483 - T-cell vaccination in the treatment of hiv infection: A method for the preparation of a T cell vaccine for the treatment of immunodeficient HIV-infected patients is described herein, based on the enrichment of autologous CD4-reactive CD8 T cells. Also described is a protocol for the implementation of T cell vaccination in immunodeficient HIV-infected, as well as a method... Agent: Kevin D. Mccarthy, Esq. Roach Brown Mccarthy & Gruber, P.C.

20100304484 - Use of alginate matrices to control cell growth: Methods of inhibiting proliferation of a plurality of proliferating cells are disclosed. Methods of inhibiting cell overgrowth on compositions that are in an animal's body are disclosed. Methods of inhibiting cell overgrowth on a device that is in an animal's body are disclosed. Devices that have on their exterior surface... Agent: Patent Administrator Fmc Corporation

20100304485 - Cell rolling separation: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.... Agent: Choate, Hall & Stewart LLP

20100304486 - Methods of generating embryoid bodies and uses of same: Methods of generating embryoid bodies (EBs) by culturing embryonic stem cells (ESCs) under static conditions followed by culturing the cells under dynamic conditions using e.g., a Glass Bulb-shaped Impeller (GBI) or shaking a culture vessel are provided. Also provided are methods of generating expanded and/or differentiated cells from the EBs... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100304487 - Soft tissue processing: t

20100304488 - Regeneration and mass propagation of jatropha curcas through somatic embryogenesis: The present invention relates to the field of somatic embryo production, particularly to methods for the regeneration of Jatropha through somatic embryogenesis. More specifically, the present invention relates to a method and media compositions for regeneration of plants of Jatropha curcas. The method is well suited for Jatropha curcas transformation... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100304489 - Methods and compositions for homologous recombination in human cells: The methods and compositions described herein are based, in part, on the discovery of a stem cell state in human cells that resembles the morphology observed in murine-derived stem cells. Induction of such a state in human stem cells permits an increase in the efficiency of homologous recombination. Thus, the... Agent: David S. Resnick

20100304490 - Method for generating a genetically modified microbe: Provided herein are methods of generating genetically modified microorganisms, e.g., genetically modified yeast strains, which comprise functional disruptions in one or more pheromone response genes and one or more sporulation genes, and genetically modified yeast cells, e.g., genetically modified diploid and haploid yeast cells, that lack sporulation capability and endogenous... Agent: Jones Day

Previous industry: Education and demonstration
Next industry: Chemistry: analytical and immunological testing


######

RSS FEED for 20140710: xml
Integrate FreshPatents.com into your RSS reader/aggregator or website to track weekly updates.
For more info, read this article.

######

Thank you for viewing Chemistry: molecular biology and microbiology patents on the FreshPatents.com website. These are patent applications which have been filed in the United States. There are a variety ways to browse Chemistry: molecular biology and microbiology patent applications on our website including browsing by date, agent, inventor, and industry. If you are interested in receiving occasional emails regarding Chemistry: molecular biology and microbiology patents we recommend signing up for free keyword monitoring by email.



Results in 3.09784 seconds

PATENT INFO