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Chemistry: molecular biology and microbiology November recently filed with US Patent Office 11/10

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
11/25/2010 > patent applications in patent subcategories. recently filed with US Patent Office

20100297599 - Transparent cooling gel: Therefore, it was necessary to produce a cooling preparation for transplantation medicine, which in a temperature range from −5° C. to 4° C. is gel-like and soft, transparent and sufficiently mechanically stable and yet remains formable. In accordance with the invention, such preparation can be produced from gelatin solutions in... Agent: Jacobson Holman PLLC

20100297600 - Flooding dish and method for changing media in the dish in the preparation of mammalian specimen culture and for cryo-preservation, freezing, vitrification and the thawing and warming of such specimens: A tray assembly which may include a single well or a plurality of wells that will contain specimens for cryo-preservation, freezing, thawing, or warming. The assembly will include a structure whereby a sequence of different media solutions can be introduced into a well or wells in the assembly without the... Agent: William W. Jones

20100297601 - Small volume and ultra speed colorimetric sensor: A sensor designed to accommodate an aqueous analyte sample having a volume of less than 1 μL and can be used to quantify the amount and concentration of such analyte through light reflectance or fiber-optic light reflectance. The sensor includes a reaction membrane and a fixed-volume sample chamber. The fixed-volume... Agent: Tom Xu

20100297603 - Analyte-releasing beads and use thereof in quantitative elispot or fluorispot assay: The present invention relates to a method of quantifying analyte secreted by a cell or released from a drug delivery vehicle, typically by ELISpot or fluorispot assay. Quantification is possible through the use of an analyte-releasing reagent that includes a bead and the analyte releasably bound to the bead, or... Agent: Nixon Peabody LLP - Patent Group

20100297602 - Apparatus and method of contaminant detection: The present invention is a method and apparatus for contaminant detection of body parts, such as hands, and or their coverings, such as clean room suits or gloves, and small objects. Particularly, the method and apparatus involve collecting air samples containing aerosolized contaminate particles from the objects and analyzing the... Agent: Law Office Of David Mcewing

20100297606 - Igg binding peptide: e

20100297611 - Method and device for combined detection of viral and bacterial infections: A lateral flow assay detects and differentiates between viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections. In one preferred embodiment, the bacterial marker is CRP.... Agent: Brown & Michaels, PC 400 M & T Bank Building

20100297604 - Methods and reagents for virus isolation and detection: The present invention relates to reagents and methods used in virus isolation and analysis.... Agent: Millen, White, Zelano & Branigan, P.C.

20100297610 - Molecularly imprinted polymers for detecting hiv-1: The invention described herein provides molecularly imprinted polymers (MIPs) that are capable of binding to virus, and methods for detecting and/or identifying specific virus particles utilizing Molecularly Imprinted Polymers (MIPs). The virus particles of the invention include HIV-1, HIV-2, HTLV-1, HTLV-2, HPV, HBV, and HCV. The methods of the invention... Agent: Womble Carlyle Sandridge & Rice, PLLC

20100297612 - Optimized probes and primers and methods of using same for the detection, screening, quantitation, isolation and sequencing of cytomegalovirus and epstein-barr virus: Described herein are primers and probes useful for detecting, screening, quantitating, isolating and sequencing CMV and EBV viral strains, and methods of using the described primers and probes.... Agent: Intelligent Medical Devices, Inc. C/o Foley & Lardner LLP

20100297607 - Reagents for hcv antigen-antibody combination assays: The present invention is directed to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a sample. The combination immunoassays of the present invention employ a non-ionic detergent that effectively exposes or releases the HCV core antigen from virions in a sample without interfering... Agent: Philip S. Johnson Johnson & Johnson

20100297605 - Screening method for prophylactic and/or therapeutic agent for disease accompanied by hepatitis c: The screening method for a prophylactic and/or therapeutic agent for hepatitis C virus-related disease according to the present invention is characterized by comprising a a step of examining the inhibitory activity of an test substance on the protein-protein interaction between hepatitis C virus core protein and PA28γ. The method can... Agent: Edwards Angell Palmer & Dodge LLP

20100297608 - Systems and methods for cmos-compatible silicon nano-wire sensors with biochemical and cellular interfaces: The systems and methods described herein include a sensor for suitable for sensing chemical and biological substances. The sensor comprises a semiconductor layer formed in or on a substrate and a channel having nano-scale dimensions formed in the semiconductor layer, where the structure creates an electrically conducting pathway between a... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100297609 - Vivo isotopic labeling method for quantitative glycomics: The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity,... Agent: Coleman Sudol Sapone, P.C.

20100297620 - Activated protease indicator: It is an object of the invention to provide novel approaches capable of detecting activated protease and also detecting protease activation on real time at a high sensitivity in a noninvasive manner. By the method for detecting activated protease of the invention, an indicator in a circular form comprising the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100297656 - Amplicon melting analysis with saturation dyes: Methods are provided for nucleic acid analysis wherein a target nucleic acid that is at least partially double stranded is mixed with a dsDNA binding dye having a percent saturation of at least 50% to form a mixture. In one embodiment, the nucleic acid is amplified in the presence of... Agent: Ice Miller LLP

20100297645 - Automatic detection of infectious diseases: The invention relates to the detection of infectious diseases. A system for automatic detection of infectious diseases is disclosed. The system comprises an input unit for receiving a blood sample, a lysis unit, a PCR unit, a sample unit and a detection unit. The systemmay based on an inputted blood... Agent: Clark & Elbing LLP

20100297625 - Biomarkers for psychosis: The present invention relates generally to the diagnosis of psychosis, schizophrenia and bipolar disorder, including psychotic bipolar disorder.... Agent: Schwegman, Lundberg & Woessner, P.A.

20100297636 - Cc2d2a gene mutations associated with joubert syndrome and diagnostic methods for identifying the same: The present invention provides a method of screening a subject for mutations in the CC2D2A gene that are associated with Joubert syndrome, an autosomal recessive form of mental retardation. The present invention also provides proteins that are associated with Joubert syndrome including proteins comprising an amino acid sequence that terminates... Agent: Winston & Strawn LLP Patent Department

20100297635 - Collection and measurement of exhaled particles: Particles are exhaled in the breath of animals. The nature and amounts of the particles can be indicative of certain medical conditions. They can therefore be collected, sorted according to size or mass and used in the diagnosis of one or more medical conditions. The invention provides a method and... Agent: Fish & Richardson P.C.

20100297631 - Compositions and methods for detecting histamine related disorders: The present invention generally relates to methods and compositions (e.g., assay kit) for the diagnosis of histamine related disorders. The invention also relates to a novel molecular target of histamine related disorders and the uses thereof for detecting or diagnosing such diseases, as well as to develop adapted and efficient... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100297658 - Detecting methylated mammalian nucleic acid in stool: This document includes methods and materials for enriching and detecting cancer markers. For example, this document includes methods and materials for enriching methylated mammalian nucleic acid from stool samples.... Agent: Casimir Jones, S.c.

20100297615 - Egfr mutations: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of a mutated... Agent: Jones Day

20100297657 - Expression profile of prostate cancer: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization... Agent: Casimir Jones, S.c.

20100297634 - Gene expression signatures in enriched tumor cell samples: The invention is embodied in methods for finding gene expression signatures of circulating melanoma cells, ovarian, breast, colorectal cancer cells, and circulating endothelial progenitor cells, which signatures are effective in distinguishing the circulating cancer cell from normal circulating cells and can also distinguish between different types of circulating cancer cells.... Agent: Medlen & Carroll, LLP

20100297619 - Genetic prediction of schizophrenia susceptibility: Provided are methods of determining the likelihood that a patient will be diagnosed with schizophrenia.... Agent: Amster, Rothstein & Ebenstein LLP

20100297640 - Hand held micro pcr device: Instant invention is about a hand held micro PCR device comprising a LTCC micro PCR chip comprising a heater, a reaction chamber to load a sample. It also comprises a heater control to regulate the heater on basis of input received from a temperature sensor. It further has an optical... Agent: Fenwick & West LLP

20100297644 - High throughput nucleic acid sequencing by spacing: Nucleic acid sequencing methods and related devices, products and kits are disclosed. Methods for sequencing a target nucleic acid comprise providing a daughter strand produced by a template-directed synthesis, the daughter strand comprising a plurality of subunits coupled in a sequence corresponding to a contiguous nucleotide sequence of all or... Agent: Seed Intellectual Property Law Group PLLC

20100297624 - Involvement of lipid kinase, and signal transduction pathway comprising said lipid kinase, in resistance to her2-targeting therapy: The invention is related to a method for determining whether an individual suffering from cancer is at risk of exhibiting or acquiring a reduced response towards HER2-targeting therapy. In one aspect, the invention utilizes the activity of a signal transduction pathway modulated by a lipid kinase for determining said risk.... Agent: Swanson & Bratschun, L.L.C.

20100297646 - Method for detection of cancer: A method for detecting a cancer(s) based on an expression of prescribed polypeptides is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine testis and serum from a cancer-bearing dog, as a polypeptide which binds to an antibody existing in serum derived from... Agent: Birch Stewart Kolasch & Birch

20100297642 - Method for determining frameshift mutations in coding nucleic acids: The present invention relates to a method for identifying frameshift mutations in coding nucleic acid sequences.... Agent: Millen, White, Zelano & Branigan, P.C.

20100297648 - Method for diagnosing susceptibility to post-traumatic scar-tissue formation: Disclosed is an in vitro method for diagnosing susceptibility to post-traumatic scar tissue formation, wherein from a biological sample of a patient the nucleotide of the -509 position of the TGF-β1 gene is determined and if said -509 position contains exclusively C, thus it is the homozygotic wild type allele,... Agent: Hahn & Voight PLLC

20100297622 - Method for high-throughput gene expression profile analysis: The present invention embraces a method for high-throughput gene profiling with high specificity and sensitivity. With this system, >1000 mRNA species can be co-amplified using gene-specific primers from a single cell. The primers are designed to amplify sequences of desirable length, which are in different exons. The exons can be... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20100297630 - Method for the simultaneous detection of multiple nucleic acid sequences in a sample: The invention is in the technical field of detecting nucleic acid sequences in a sample, such as the detection of pathogenic organisms in clinical samples. More specifically, the invention relates to the field of detecting an infection caused by a pathogenic organism such as a virus or a bacterium in... Agent: Nixon & Vanderhye, PC

20100297633 - Method of amplifying nucleic acid: The present invention provides a method for detecting a polymorphism or mutation in nucleic acid comprising a first phase to amplify or enrich for a sequence comprising a polymorphism or mutation and a second phase for detecting the polymorphism or mutation, wherein both phases are performed in the same reaction... Agent: Knobbe Martens Olson & Bear LLP

20100297649 - Methods and materials for detecting gene amplification: This document relates to methods and materials involved in detecting gene amplification in a mammal. For example, methods and materials for detecting amplification at CPM and MDM2 loci to determine the presence or absence of a malignant lipomatous neoplasm in a mammal are provided.... Agent: Fish & Richardson P.C.

20100297618 - Methods for determining a prognosis of colorectal cancer: The invention provides methods for determining a prognosis of colorectal cancer in an individual comprising determining an A-type lamin status of an individual and using the A-type lamin status to determine the prognosis of the colorectal cancer, and more particularly for predicting outcomes of colorectal cancer in the individual such... Agent: Dann, Dorfman, Herrell & Skillman

20100297653 - Methods of diagnosing and treating cancer: The invention features methods of evaluating the risk of cancer recurrence in a subject diagnosed with cancer.... Agent: Lando & Anastasi, LLP

20100297651 - Methods of modulating vesicular trafficking: Described are methods of identifying compounds useful for modulating vesicular trafficking, particularly those that disrupt the interactions between ARNO and the V-ATPase a2-subunit. Also described are peptides that modulate vesicular trafficking.... Agent: Fish & Richardson PC

20100297628 - Methods of producing and sequencing modified polynucleotides: The present invention encompasses methods for producing a modified polynucleotide sequence that comprises a (e.g., one or more) phosphorothiolate linkage, methods for determining a polynucleotide sequence comprising a (e.g., one or more) phosphorothiolate linkage, and methods for separating forward and reverse extension products that comprise a (e.g., one or more)... Agent: Life Technologies Corporation C/o Intellevate

20100297641 - Methylation altered dna sequences as markers associated with human cancer: There is disclosed 103 novel methylation-altered DNA sequences (“marker sequences”) that have distinct methylation patterns in cancer, compared to normal tissue. In many instances, these marker sequences represent novel sequences not found in the GenBank data base, and none of these marker sequences have previously been characterized with respect to... Agent: Davis Wright Tremaine, LLP/seattle

20100297627 - Microrna diagnostics for cancer: Disclosed are methods for detecting breast cancer or prostate cancer by measuring levels of miR-204 and miR-510 in samples.... Agent: Musc Foundation For Research Development

20100297652 - Mirna biomarkers of prostate disease: This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing prostate disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as prostate cancer.... Agent: Asuragen Inc./finnegan

20100297638 - Molecular adaptors: The invention relates to transmembrane protein pore for use in detecting a analyte in a sample. The pore comprises a molecular adaptor that facilitates an interaction between the pore and the analyte. The adaptor is covalently attached to the pore in an orientation that allows the analyte to be detected... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100297623 - Novel human ssdna binding proteins and methods of cancer diagnosis: A method for detecting transformed cells or tumour cells, a method for diagnosing or prognosing cancer or for assessing a predisposition to cancer, and kits for use in the methods are disclosed. The methods particularly involve the detection of overexpression of an ssDNA binding protein (SSB) or polypeptide comprising the... Agent: Sheridan Ross PC

20100297650 - Nucleic acid and corresponding protein entitled 193p1e1b useful in treatment and detection of cancer: A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The... Agent: Agensys C/o Morrison & Foerster LLP

20100297629 - Nucleic acid supported protein complementation: The present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present invention is based on protein complementation, in which two individual polypeptides are inactive. When the two inactive... Agent: Morrison & Foerster LLP

20100297613 - Nucleic acid, amino acid encoded by said nucleic acid, probe comprising said nucleic acid or said amino acid, and screening method using said probe: e

20100297647 - Polymerase-based single-molecule sequencing: The invention relates to an assay method for determining the base sequence in a nucleic acid sample which comprises detection of a single base in said sequence using a polymerase modified to include at least one fluorophore and a dark quencher group; detecting and deducing the amount of energy transfer.... Agent: Speckman Law Group PLLC

20100297637 - Primer for amplification of rrna or bacterium belonging to the genus legionella, detection method, and detection kit: To detect a bacterium belonging to the genus Legionella rapidly, with high sensitivity, and specifically. Disclosed are: a primer set for amplifying ribosomal RNA of a bacterium belonging to the genus Legionella specifically and highly efficiently; and a method for detecting ribosomal RNA of a bacterium belonging to the genus... Agent: Sughrue Mion, PLLC

20100297617 - Primer set for amplifying nat2 gene, reagent for amplifying nat2 gene containing the same, and the uses thereof: Primer sets for amplifying target regions containing sites to be detected in the NAT2 gene by a gene amplification method are provided, wherein the primer sets can amplify the regions specifically. Three pairs of primer sets are used including forward primers consisting of the base sequences of SEQ ID NOs:... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100297614 - Process for the detection of cytosine methylations: The invention concerns a method for the detection of cytosine methylations in DNA and a kit for undertaking an assay according to the method of the invention.... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100297639 - Quantitative/semi-quantitative measurement of epor on cancer cells: The present invention provides for assays useful in predicting whether a cancer patient risks suffering erythropoietin-induced tumor progression if treated with erythropoietin. More specifically, one embodiment provides for a validated quantitative reverse transcriptase polymerase chain reaction assay that detects erythropoietin receptor expression, thus indicating whether a cancer patient risks suffering... Agent: Nixon Peabody LLP - Patent Group

20100297626 - Reagents, methods, and libraries for bead-based sequencing: The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate... Agent: Life Technologies Corporation C/o Intellevate

20100297660 - Single nucleotide polymorphisms associated with renal disease: Methods for determining the genetic predisposition of a human subject to developing renal disease, such as focal segmental glomerulosclerosis (FSGS) or end-stage kidney disease are provided herein. These methods include methods for detecting renal disease, or determining the risk of developing renal disease in a human subject, such as a... Agent: Klarquist Sparkman, LLP (ott-nih)

20100297616 - Situ hybridisation method: There is provided an improved method of in situ hybridisation. In particular, a method of in situ hybridisation of biopolymer(s) in a sample of cells, with the proviso that the digestion of polypeptides is not performed. The method may be applicable to detection of different types of biopolymers, including detection... Agent: Clark & Elbing LLP

20100297655 - Socs-1 gene methylation in cancer: Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In addition, methods of treating a cancer patient, wherein cancer cells in the patient exhibit methylation-silenced transcription... Agent: Dla Piper LLP (us)

20100297643 - Terminus-specific dna modification using random-sequence template oligonucleotides: A method is provided for analyzing DNA molecules having unknown 3′ terminal sequences. The method involves contacting a DNA molecule with a plurality of template oligonucleotides blocked at their 3′ termini such that the template oligonucleotides are not extendable by DNA polymerase. The 3′ proximal portions of each of the... Agent: Casimir Jones, S.c.

20100297659 - Thin-film layered centrifuge device and analysis method using the same: Disclosed herein is a thin-film layered centrifuge device and an analysis method using the same. One example of an embodiment of the present invention is a thin film layered centrifuge device where a device, such as a lab on a chip, a protein chip and a DNA chip, for diagnosing... Agent: Staas & Halsey LLP

20100297654 - Three-component biosensors for detecting macromolecules and other analytes: The invention generally provides three-component molecular biosensors. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules.... Agent: Polsinelli Shughart PC

20100297632 - Upregulation of rack-1 in melanoma and its use as a marker: The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocyte cell of said mammal, and the deduction of the presence of a melanoma from the overexpression of RACK-1 protein. The invention is also directed to... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100297621 - Use of pre-mrna splicing in platelet cells for the diagnosis of disease: The invention relates to materials and procedures for identifying or using tissue factor (TF) pre-mRNA splicing, CIk 1 activity or TF-dependent coagulation in platelet cells for the diagnosis, prognosis, or prediction of a disease or disorder associated with disordered coagulation. Since activated platelets splice pre-mRNAs to generate inflammatory and thrombotic... Agent: Morriss Obryant Compagni, P.C.

20100297662 - Antibody and use thereof: An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid β fibrils or monomeric amyloid β-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100297661 - Diagnostic composition and kit for renal cell carcinoma: Disclosed herein are a composition and a kit for diagnosing renal cell carcinoma. The composition and kit employ, as a renal cell carcinoma marker, nicotinamide N-methyltransferase, L-plastin, secretagogin, NM23A, CapG, which is an actin regulatory protein, and/or C4a anaphylatoxin.... Agent: Intellectual Property Law Group LLP

20100297663 - Methods and systems for assaying, maintaining, and enhancing the activity of the immune system of a subject: A method for non-invasively assessing a subject's health includes evaluating a state of a subject's immune response. Such a method may include obtaining a salivary sample from the subject and assaying the salivary sample for IgA. The state of a component of the subject's immunity may be evaluated in conjunction... Agent: Durham, Jones & Pinegar -- Intellectual Property Law Group

20100297664 - Paratope and epitope of anti-mortalin antibody: The amino acid sequences of paratope regions involved in internalizing function of an anti-mortalin antibody into tumor cells were determined for the L-chain and H-chain variable regions of cellular internalizing anti-mortalin antibodies and non-internalizing anti-mortalin antibodies. Cancer-cell-specific drug delivery is provided by using the mortalin-binding activity of a single-chain antibody... Agent: Sughrue Mion, PLLC

20100297672 - Highly sensitive system and methods for analysis of troponin: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100297671 - Method and device for the quantitative determination of analytes in liquid samples: The invention relates to a method and a device for the highly sensitive parallel detection and quantitative determination of analytes in liquid samples. According to said method, total internal reflection fluorescence (TIRF) is used in combination with a binding inhibition test on a specially coated support. The inventive method makes... Agent: Kf Ross PC

20100297673 - Methods and compositions for upregulation of peroxiredoxin activity: A novel method of identifying compounds capable of upregulating Peroxiredoxin activity is disclosed. The method includes providing a sample of cells that express Peroxiredoxin, providing a sample of a candidate compound, contacting the cell sample and the compound sample, and measuring a quantitative indicator of Peroxiredoxin activity within the cell... Agent: Nelson Mullins Riley & Scarborough LLPIPDepartment

20100297674 - Novel cell lines expressing nav and methods using them: Cells and cell lines that express voltage-gated sodium ion channels (NaV) and methods for using the cells and cell lines are disclosed herein. The NaV-expressing cells and cell lines are useful in high throughput screening assays.... Agent: Ropes & Gray LLP

20100297675 - Substrate and method for culturing breast cells: A cell culture article includes a porous substrate having a plurality of pores and a plurality of interstices in communication with the pores. At least some of the plurality of pores and interstices are sufficiently large for two or more mammary epithelial cells to cluster within the pores or interstices.... Agent: Corning Incorporated

20100297676 - Methods for diagnosis, prognosis and methods of treatment: This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of a cell present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to... Agent: Wilson, Sonsini, Goodrich & Rosati / Nodality, Inc

20100297677 - Cycochrome c synthesis inhibitors: The invention provides methods for identifying a compound that inhibits cytochrome c synthesis. This invention further provides a method for the high throughput screening of compounds that inhibit cytochrome c synthesis.... Agent: Polsinelli Shughart PC

20100297668 - Human e3alpha ubiquitin ligase family: The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells, antibodies and recombinant methods for producing the polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for these... Agent: Amgen Inc.

20100297667 - Method for diagnosis of disease using quantitative monitoring of protein tyrosine phosphatase: The present invention relates to a method for quantifying protein tyrosine phosphatase (referred as PTP hereinafter) in biosamples, precisely a diagnostic method for disease by quantifying PTP using mass spectrometry and profiling of comparative PTP levels. By quantifying PTP in biosamples and profiling thereof according to the method of the... Agent: Klarquist Sparkman, LLP

20100297665 - Method for testing and screening p38 map kinase modifiers: This invention provides methods for treating diseases associated with elevated p38 mitogen-activated protein kinase activity. Moreover, the invention provides methods for testing a candidate compound for a p38 mitogen-activated protein kinase modifying activity by calculating the level of relocalization of an SMN complex component from the cytoplasm to the nucleus... Agent: Pearl Cohen Zedek Latzer, LLP

20100297666 - Methods for determination of protein phosphatase activity, and uses in predicting therapeutic outcomes: One aspect of the present disclosure encompasses methods for determining a protein kinase or phosphatase activity in a biological sample, comprising: contacting in a reaction mix a first test sample and a fluorescently-labeled peptide substrate capable of being modified by a protein phosphatase or a protein kinase, contacting the reaction... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100297670 - Methods for detection of immunosuppressant drugs: Methods and reagents are disclosed for enhancing the bioavailability of a hydrophobic drug, and in some embodiments for determining a hydrophobic drug, in a sample suspected of containing a hydrophobic drug. A combination is formed in a medium where the combination comprises the sample, a hemolytic agent where a determination... Agent: Siemens Corporation Intellectual Property Department

20100297669 - Nucleic acids and corresponding proteins entitled 191p4d12(b) useful in treatment and detection of cancer: A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or... Agent: Agensys C/o Morrison & Foerster LLP

20100297678 - Biomarkers for multiple sclerosis: The present invention relates to the diagnosis of neurological disorders, more specifically to the diagnosis of multiple sclerosis. A biomarker panel is provided which can be used to detect if a subject has multiple sclerosis. Also described are methods of identification of such biomarkers.... Agent: Marshall, Gerstein & Borun LLP

20100297679 - Identification and quantification of biomarkers for evaluating the risk of preterm birth: Described herein are methods for evaluating the risk of preterm birth in pregnant subjects. The methods involve detecting and quantifying one or more biomarkers associated with preterm birth in a biological sample from the subject. Also described herein are isolated biomarkers and kits useful in predicting the risk of preterm... Agent: Gardner Groff Greenwald & Villanueva. PC

20100297680 - Methods for assessing the risk for development of cardiovascular disease: The present invention relates to diagnostic tests, methods and kits that are useful to assess a subject's risk of developing a pathologic condition related in part to the presence of HDL oxidation product. Measuring the quantity of one or more HDL oxidation products present in the blood is useful in... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20100297681 - Fluorescent probe for measurement of glucuronate transferase: A fluorescent probe for measurement of UDP-glucuronosyltransferase, which comprises a fluorescein derivative, wherein in the fluorescein derivative, the 2-carboxy group on the benzene ring of fluorescein is replaced with another monovalent substituent, provided that said substituent is a substituent other than sulfo group, and the substituent does not have carboxy... Agent: Greenblum & Bernstein, P.L.C

20100297682 - Method of diagnostic rheumatoid arthritis by sugar chain analysis: Provided is a novel method of diagnosing rheumatoid arthritis. Based on the quantitative expression profile of sugar chain expression amount in the serum (whole serum, HAP or LAP), the relevancy thereof to rheumatoid arthritis is analyzed. As a result, a sugar chain and a glycoprotein showing a change depending on... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100297683 - Method: The present invention provides a method for the detection of a protease comprising the use of a substrate partially coated with a film of a synthetic polymeric matrix comprising a peptide of up to 20 amino acids. Apparatus for performing such methods is also disclosed.... Agent: Pepper Hamilton LLP

20100297684 - Activatible dyes: Novel, activatable dyes, such as photoactivatable dyes, e.g., oxazine dyes, are described. Some of the dyes are targeting dyes that can, e.g., target biomolecules, such as polypeptides, proteins, or nucleic acids. Upon activation, such as by irradiation, the novel dyes rapidly turn on their fluorescence and emit light, such as... Agent: Fish & Richardson PC

20100297687 - Detection and measurement of mass change using an electromechanical resonator: A change in impedance of a electromechanical resonating sensor is utilized to detect and/or measure a change in mass accumulated on the sensor. The impedance is monitored at a fixed frequency. The fixed frequency may be at or near the resonance frequency of the sensor. In various configurations, the sensor... Agent: Woodcock Washburn LLP

20100297686 - Devices for intracellular surface-enhanced raman spectroscopy: Provided are surface-enhanced Raman spectroscopy (SERS) devices suitable for intra-subject (e.g., intracellular) observation, which devices may be of nanoscale size. Also provided are related SERS analysis methods.... Agent: Woodcock Washburn LLP

20100297688 - Method for diagnosing or predicting short stature in humans: An improved assay for measuring the release of endogenous growth hormone (GH) is described. The method focuses on determining the presence of an immediate release pool (IRP) of GH, and the extent to which it is rapidly discharged into the circulation of humans, including children. A larger and less labile... Agent: Scully Scott Murphy & Presser, PC

20100297685 - Methods for culturing and analyzing cells: The present invention generally relates to methods for culturing and analyzing cells using liquid bridges.... Agent: Life Technologies Corporation C/o Intellevate

20100297689 - Placental stem cell populations: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.... Agent: Jones Day

20100297690 - Detection of salmonella lactose+: The invention relates to a medium for the detection and/or identification of Salmonella, including Salmonella lactose+.... Agent: Blakely Sokoloff Taylor & Zafman LLP

20100297691 - Devices and processes for collecting and concentrating samples for microbiological analysis: The present invention refers to manual devices for the collecting and concentrating liquid samples for microbiological analysis and their respective methods of use. The manual devices comprise a body which contains a sample, a removable support, a microporous membrane, and a plunger. The present invention is also directed to methods... Agent: 3m Innovative Properties Company

20100297692 - Reaction medium for detecting and/or identtifying staphyloccous aureus: e

20100297693 - Production of carrier-peptide conjugates using chemically reactive unnatural amino acids: Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods... Agent: Quine Intellectual Property Law Group, P.C.

20100297696 - Enzyme production in culture medium comprising raw glycerol: The present invention is directed to a method of producing desired proteins from a host cell grown in a media comprising raw glycerol as a carbon source.... Agent: Danisco US Inc. Attention: Legal Department

20100297697 - Methods for increasing protein titers: The invention relates to methods of increasing the titre of a protein of interest in a cell as well as the improved production and purification of optimised biomolecules, one component of which is the domain CH3. A frequently observed effect in biomolecules is the cleaving of the C-terminal amino acid(s),... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100297694 - Novel gene from hancenula polymorpha capable of controlling unfolded protein response and method for increasing effect of secretion using the same: The present invention relates to a novel H. polymorpha gene regulating Unfolded Protein Response (UPR) and a method for improving the efficiency of secretory expression of a recombinant protein using the same, more particularly, a method for improving the efficiency of secretory expression of a recombinant protein by identifying, modifying,... Agent: Casimir Jones, S.c.

20100297695 - Nucleic acids encoding chimeric cd154 polypeptides: The present invention provides for an isolated polynucleotide sequence encoding a chimeric CD154, comprising a first nucleotide sequence encoding an extracellular subdomain of non-human CD154, preferably murine CD154, that replaces a cleavage site of human CD154, and a second nucleotide sequence encoding an extracellular subdomain of human CD154 that binds... Agent: Dla Piper LLP (us)

20100297698 - System and method for producing synthetic microorganisms capable of translating proteins containing non-standard amino acids: The disclosed invention relates to the generation of host cells containing rare codons and/or absent tRNAs, and the use of orthogonal tRNA systems that can insert a non-standard amino acid into a growing peptide chain. This invention combined with the capacity to synthesize whole genomes has important implications in synthetic... Agent: Synthetic Genomics C/o Mofo

20100297700 - Antibodies to tnf alpha: Provided herein are antibodies, antigen binding portions, and derivatives thereof that are capable of binding tumor necrosis factor alpha (TNFα); nucleic acids encoding the antibodies, antigen binding portions, and derivatives thereof, including complementary nucleic acids; vectors; and host cells containing the nucleic acids.... Agent: Banner & Witcoff, Ltd.

20100297699 - Nucleic acids encoding humanized immunoglobulin that binds alpha4beta7 integrin: The invention relates to an isolated nucleic acid encoding a humanized immunoglobulin that has binding specificity for α4β7 integrin and comprises the complementarity determining regions (CDRs) of mouse Act-1 antibody. The present invention further relates to an isolated nucleic acid encoding a humanized heavy chain and an isolated nucleic acid... Agent: Mcdermott Will & Emery

20100297701 - Trimerizing polypeptides: The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of... Agent: Zymogenetics, Inc. Intellectual Property Department

20100297702 - Protein markers associated with bone marrow stem cell differentiation into early progenitor dendritic cells: A novel cytosolic 58 kd phosphoprotein induced during bone marrow stem cell (BM) differentiation into dendritic cells (DC) during in vitro cultivation with the cytokine GM-CSF by addition of antisera to an 82 kd BM cell surface protein generating cultivatable dendritic progenitor cells (DP). Genes, methods for preparing them as... Agent: Edward T. Lentz

20100297703 - Lytic enzyme inhibitor, lysis inhibitor, inhibitor of poly-y-glutamic acid degradation, and method for producing poly- y-glutamic acid: This invention relates to inhibition of microbial lysis via regulation of activity of a lytic enzyme for degrading the cell wall. The lytic enzyme inhibitor and the lysis inhibitor are each composed mainly of the Bacillus subtilis-derived YoeB gene or the YoeB protein encoded by a gene homologous to the... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100297704 - Process for biomass conversion: The present invention relates to a clean process of preparing high grade biomass products, and their use in the production of health care products, bio-energy products, biochemicals, bio-originated chemicals and biodegradable plastics.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100297705 - Processing biomass: Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can convert feedstock materials to a sugar solution, which can then be fermented to produce ethanol. Biomass feedstock is saccharified in a vessel by... Agent: Xyleco, Inc. Celia Leber

20100297708 - Molecular diagnostics system and methods: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostics testing.... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20100297706 - Mutant dna polymerases and their genes from thermococcus: The present invention relates to mutant DNA polymerases and their genes isolated from Thermococcus sp. More specifically, the present invention relates to mutant DNA polymerases which are originally isolated from Thermococcus sp NA1. strain and produced by site-specific mutagenesis, their amino acid sequences, genes encoding said mutant DNA polymerases, their... Agent: Edwards Angell Palmer & Dodge LLP

20100297707 - Reaction vessel comprising conductive layer and inner non-metallic layer: A reaction vessel for conducting a chemical or biochemical reaction, such as a polymerase chain reaction wherein at least one wall of said vessel comprises a metallic layer and an inner non-metallic layer. Reaction systems comprising combinations of vessels of the invention and apparatus for heating them, as well as... Agent: Polsinelli Shughart PC

20100297709 - Methods for enrichment of selected rna molecules: Improved methods of studying RNA molecules are provided. In particular, methods of treating mixtures of RNA molecules so as to enrich the mixture for a desired type of RNA molecule are provided. For example, the methods permit depletion of mRNA from complex mixtures to facilitate study of microRNAs in the... Agent: Perkins Coie LLP

20100297710 - Methods and compositions for the extraction and amplification of nucleic acid from a sample: Provided herein are methods, compositions and kits to extract and relatively enrich by physical separation or amplification short base pair nucleic acid in the presence of a high background of genomic material (e.g., host or maternal nucleic acids).... Agent: Grant Anderson LLP C/o Portfolioip

20100297711 - Process for the synthesis of fosinopril and intermediates thereof: Process for the preparation of intermediates useful in the synthesis of [1[S(R)],2α,4β]-4-cyclohexyl-1-[[[(2-methyl-1-oxypropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline, and the synthesis thereof, in particular as sodium salt.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100297712 - Hydroxylase gene and use thereof: A vitamin D3 hydroxylase is purified from Pseudonocardia autotrophica cell, and a primer is designed based on amino acid sequence obtained from hydroxylase. Subsequently, PCR is conducted using genomic DNA of Pseudonocardia autotrophica as a template to clone a gene for the vitamin D3 hydroxylase. By conducting a conversion reaction... Agent: Sughrue Mion, PLLC

20100297714 - Multi-step method for producing algae products: A multi-step method for producing an algae product comprising, a microorganism consumption step, another step, and an algae product collection step. The microorganism consumption step comprises, combining a liquid growth medium comprising microorganisms with a phagotrophic algae capable of producing a desired algae product, consuming said microorganisms by said phagotrophic... Agent: Brouse Mcdowell Lpa

20100297713 - Mutant delta-8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids: The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100297716 - Method for producing an organic acid: An organic acid is produced by allowing a bacterium belonging to the family Enterobacteriaceae, which has an ability to produce an organic acid and has been modified so that the phosphoenolpyruvate carboxykinase activity is enhanced, which is selected from Enterobacter, Pantoea, Erwinia, Klebsiella and Raoultella bacteria, or a product obtained... Agent: Cermak Nakajima LLP Acs LLC

20100297715 - Method for producing succinic acid: The invention relates to methods for producing succinic acid and/or succinate ions by fermentation under anaerobic conditions.... Agent: Young & Thompson

20100297717 - Method of producing alcohol in the biorefinery context: e

20100297718 - Processes of producing fermentation products: The invention relates to processes of fermenting plant material into a fermentation product using a fermenting organism, wherein one or more compounds capable of activating a sirtuin protein is present during fermentation.... Agent: Novozymes North America, Inc.

20100297719 - Methods to control bacterial growth in fermentation processes: A method of producing a fermentation-based product, such as ethanol, comprises fermenting a sugar-containing medium with yeast in the presence of an aliphatic or aromatic monoaldehyde or dialdehyde, a formaldehyde-releasing compound, or a combination thereof, in an amount sufficient to reduce or control a bacterial population in the sugar-containing medium.... Agent: The Dow Chemical Company

20100297720 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed for use in the production of useful products, such as fuels. For example, systems can use biomass materials, such as cellulosic and/or lignocellulosic materials, to enhance the production of a product, e.g., the production of ethanol and/or butanol... Agent: Xyleco, Inc. Celia Leber

20100297721 - Gene knockout mesophilic and thermophilic organisms, and methods of use thereof: One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20100297722 - Transgenic moss producing terpenoids: The present invention generally relates to transgenic moss. One aspect of the invention provides a transgenic moss cell that produces or accumulates a terpenoid compound. Another aspect of the invention provides for methods of producing a terpenoid compound through culturing of the transgenic moss.... Agent: Sonnenschein Nath & Rosenthal LLP

20100297723 - Heat-stable carbonic anhydrases and their use: The present invention relates to use of heat-stable carbonic anhydrase in CO2 extraction, e.g., from flue gas, natural gas or biogas. Furthermore, the invention relates to isolated polypeptides having carbonic anhydrase activity at elevated temperatures and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors,... Agent: Novozymes North America, Inc.

20100297724 - Metal entrapped compounds: The present invention provides a composite comprising at least one hydrophobic organic compound and a matrix of at least one metal; wherein said at least one hydrophobic compound is entrapped within said matrix, compositions comprising at least one composite and methods of its preparation.... Agent: The Nath Law Group

20100297725 - Haptens, hapten conjugates, compositions thereof and method for their preparation and use: A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties... Agent: Klarquist Sparkman, LLP

20100297726 - Stabilized transglutaminase and process for production thereof: Disclosed is a transglutaminase having excellent stability. Also disclosed is a process for producing the transglutaminase. Specifically disclosed is a stabilized transglutaminase, which has such a structure in which a pro-sequence peptide of transglutaminase is bound to a mature transglutaminase. Also specifically disclosed is a process for producing stabilized transglutaminase,... Agent: Edwards Angell Palmer & Dodge LLP

20100297727 - Methods for improving protein performance: The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for altering the... Agent: Danisco US Inc. Attention: Legal Department

20100297728 - Random-primed transcriptase -in vitro transcription method for rna amplification: A random-primed reverse transcriptase-in vitro transcription method of linearly amplifying RNA is provided. According to the methods of the invention, source RNA (or other single-stranded nucleic acid), preferably, mRNA, is converted to double-stranded cDNA using two random primers, one of which comprises a RNA polymerase promoter sequence (“promoter-primer”), to yield... Agent: Life Technologies Corporation C/o Intellevate

20100297729 - Process for producing transglutaminase: An intended foreign protein, in particular, transglutaminase, is produced by using an expression construct wherein the gene sequence of the intended foreign protein containing the pro-structure part, in particular, pro-transglutaminase gene sequence, is ligated to the downstream of a sequence encoding the signal peptide region from a coryneform bacterium, introducing... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100297731 - Novel adenoviruses, nucleic acids that code for the same and the use of said viruses: The present invention is related to an adenovirus expressing a first protein which is selected from the group comprising an E1B protein and an E4 protein, prior to a second protein which is selected from the group comprising an E1A protein.... Agent: Lisa Mueller C/o Polsinelli Shughart PC

20100297730 - Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus: The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products... Agent: Jones Day

20100297732 - Vectors with modified protease-dependent tropism: The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these... Agent: Clark & Elbing LLP

20100297733 - Systems and methods for the capture and separation of microparticles: Systems and methods are provided for capturing and/or isolating target microparticles. In one aspect, a method for capturing target microparticles is disclosed. The method includes: forming a fluid including the target microparticles, non-target microparticles, and magnetic beads, the magnetic beads having a stronger affinity with the target microparticles than with... Agent: Baker Botts L.L.P.

20100297734 - Fusion tag comprising an affinity tag and an ef-hand motif containing polypeptide and methods of use thereof: The application discloses a fusion tag comprising an affinity tag and a polypeptide comprising one or more EF hand motif(s). Preferably, said fusion tag comprises a polyhistidine tag, one or more EF hand motif(s) of calmodulin and a thrombin cleavage site. Methods of using said fusion tag to purify a... Agent: Ballard Spahr LLP

20100297735 - Compound ws 727713: The present invention relates to a new compound useful as a modulator of melanocortin receptors. In particular, the present invention relates to a compound WS727713, a process for production of the compound by culturing, in a culture medium, a WS727713-producing strain belonging to Pseudonocardia and recovering the compound from a... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100297736 - Genetically modified photoautotrophic ethanol producing host cells, method for producing the host cells, constructs for the transformation of the host cells, method for testing a photoautotrophic strain for a desired growth property and method of producin: The invention provides genetically modified photoautotrophic ethanol producing host cells. Ethanol production is controlled by an inducible promoter. Promoters utilized may be endogenous or heterologous, and genetic modification may be obtained by extrachromosomal means or chromosomal insertion.... Agent: Algenol Biofuels, Inc.

20100297737 - Microbial fuel cell: Transgenic microbes with an altered electrogenic efficacy, biofilms comprising such microbes, and microbial fuel cells comprising such microbes are provided. The microbial fuel cells can be operated as monitors, filtration devices, and sensors.... Agent: Taft, Stettinius & Hollister LLP

20100297738 - Expression system: The present invention relates to methods for increasing the secretion of a protein of interest (POI) from a eukaryotic cell comprising co-expression of a POI and of at least one protein that enhances protein secretion, said enhancing protein being selected from the group consisting of BMH2, BFR2, C0G6, C0Y1, CUP5,... Agent: Oliff & Berridge, PLC

20100297739 - Renewable energy system: An apparatus for cultivating photosynthetic organisms is provided. The apparatus can be used in a renewable energy system. The apparatus comprises a chamber for growing photosynthetic organisms in a liquid medium; a device for holding the photosynthetic organism; a carbon dioxide source; a medium intake source; and a system for... Agent: The Webb Law Firm, P.C.

20100297741 - Grape extract, dietary supplement thereof, and processes therefor: The present invention relates to a novel grape extract, and processes for making such, that is useful for, inter alia, treating pre-hypertension, Metabolic Syndrome and/or the conditions that comprise Metabolic Syndrome. The processes of the present invention produce a highly concentrated polyphenol product by maximizing extraction of monomeric and oligomeric... Agent: Kenyon & Kenyon LLP

20100297740 - Use of anaerobic digestion to destroy biohazards and to enhance biogas production: The invention relates to systems and methods for using the anaerobic digestion (AD) process, especially thermophilic anaerobic digestion (TAD), to destroy biohazard materials including prion-containing specified risk materials (SRM), viral, and/or bacterial pathogens, etc. The added advantage of the invention also includes using feedstocks that may contain such biohazard materials... Agent: Mccarter & English, LLP Boston

20100297742 - Method and device for thermal enzymatic hydrolysis of ligno cellulose: A method for thermal enzymatic hydrolysis of ligno cellulose is provided by feeding a raw material based on ligno cellulose, pH-adjusting and other additives and possibly thinner liquid into one or more reactors, supplying steam to heat and increase the pressure in the reactor, relieving the pressure in the reactor... Agent: Brooks Kushman P.C.

20100297743 - Coenzyme-binding glucose dehydrogenase: The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has an activity to maltose as low as 5% or less, and is inhibited by 1,10-phenanthroline. The invention also provides a method for producing the coenzyme-binding... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100297745 - Flow-through method of functionalizing inner surfaces of a microfluidic device: The present invention refers to a flow-through method of functionalizing an inner surface of a microfluidic device. The method can comprise transporting a silanizing solution through the microfluidic device to silanize the inner surface of the microfluidic device. The method can further comprise reacting the silanized surface with an oxidized... Agent: Seed Intellectual Property Law Group PLLC

20100297744 - Multi-channel bioreactor with the immobillization of optical sensing membrane: The present invention relates to a multi-channel microbioreactor. More specifically, the present invention relates to a multi-channel microbioreactor having a number of wells in which an optical sensing membrane comprising a fluorescent dye and a bioconjugate, or a sensor material including a biomolecule conjugated to a fluorescent dye and a... Agent: The Webb Law Firm, P.C.

20100297746 - Standing wave fibers for the detection of nucleic acids: The present invention provides a standing wave fiber assembly for the collection and detection of a biological target in a complex biological fluid, including: an oscillator; and an elongated fiber coupled to the oscillator, wherein the elongated fiber is selectively exposed to a fluid potentially containing the biological target, and... Agent: Clements Bernard PLLC

20100297747 - System and method for monitoring cell growth: Microsystem for monitoring cell growth. A microfluidic structure is designed to allow cells to circulate therethrough and the microfluidic structure includes modules to monitor mass, mass density and fluorescence of the cell.... Agent: Choate, Hall & Stewart LLP

20100297748 - Integrated fluidic circuits: The invention generally relates to an integrated fluidic circuit. In certain embodiments, the circuit includes a main chamber having a withdrawal port, a carrier fluid occupying a volume in the chamber, in which the carrier fluid is immiscible with a sample fluid, and a plurality of liquid bridges disposed within... Agent: Brown Rudnick LLP

20100297749 - Methods and systems for biofuel production: The present disclosure relates to methods and systems for biofuel production. Systems of integrated biorefineries (IBR) and methods of using IBRs for producing fuel compositions and other products are provided herein. The IBRs can use algae for generating biofeedstock to produce the fuel compositions.... Agent: Sapphire Energy, Inc.

20100297752 - Mn gene and protein: Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked... Agent: Leona L. Lauder

20100297751 - Non-ribosomal peptide synthetases: Novel tailor-made artificial non-ribosomal peptide synthetases (NRPSs) for non-ribosomal synthesis and/or modification of peptides of a predetermined length and composition and/or for modification of individual amino acids are described. The fusion of building units of said peptide synthetases in particular linker regions makes it possible to specifically prepare by means... Agent: K&l Gates LLP

20100297750 - Polynucleotide or analogue thereof, and gene expression regulation method using the polynucleotide or the analogue thereof: [Means to Achieve Objectives] Provided is a polynucleotide or polynucleotide analogue, comprising a nucleotide sequence complementary to at least part of a cis element of mRNA and a nucleotide sequence complementary to part of the 5′- and/or 3′-untranslated region of the cis element, wherein the polynucleotide or polynucleotide analogue inhibits... Agent: Birch Stewart Kolasch & Birch

20100297754 - Device for carrying out cell lysis and nucleic acid extraction: The present invention provides an integrated lab-on-a-chip device for carrying out a nucleic acid extraction process on a fluid sample containing cells and/or particles, the device comprising: (a) a sample inlet (1) for loading of a fluid sample, (b) a lysis unit (4) for lysis of cells and/or particles present... Agent: Wolf Greenfield & Sacks, P.C.

20100297753 - Transfection by laser poration on rotating cylinder: Biological cells are transfected by a laser poration process in which the structures are immobilized on a solid surface that is cylindrical in shape, and the cylinder, while immersed in a liquid solution of the transfecting species or otherwise in contact with the solution, is rotated past a stationary laser... Agent: Townsend And Townsend And Crew, LLP

20100297755 - method for differentiating of human embryonic stem cells into the osteoblastic lineage: Disclosed are a composition for introducing the osteogenic differentiation of human embryonic stem cells and a method for differentiating human embryonic stem cells into an osteoblastic lineage by inhibiting the mTOR signaling pathway. When cultured in the presence of an inhibitor of the mTOR signaling pathway, human embryonic stem cells... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100297758 - Artificial peptide and use thereof: The present invention provides a method of transporting a peptide motif of interest into a nucleus of a eukaryotic cell from outside the cell, including: synthesizing a peptide chain having an amino acid sequence constituting the peptide motif of interest at an N-terminal end or a C-terminal end of a... Agent: Turocy & Watson, LLP

20100297756 - Means for delivery of nucleic acids active for gene silencing using synthetic polymers: The invention relates to a composition useful as transfection agent, comprising polyamines modified by aromatic amino acids and small double-strand or single-strand RNA active for RNA interference.... Agent: Nixon & Vanderhye, PC

20100297757 - Renal progenitor cells from embryonic stem cells: The present invention relates to compositions and methods for inducing the differentiation of stem cells into renal progenitor cells. In particular, the present invention provides compositions containing activin-a, retinoic acid, and bmp-7, and variants thereof, for differentiating stem cells into renal cells containing tubular epithelia. In certain embodiments, the present... Agent: Casimir Jones, S.c.

20100297759 - System and process for sorting biological particles in liquid flow: The embodiment of the present invention is to provide a system for sorting biological particles in a liquid flow, such as a cell sorter, which comprises an optical mechanism emitting laser beam onto each of the biological particles to detect light therefrom, a controller determining a moving speed of each... Agent: Lillian Medina-zelazny

20100297761 - Novel use of liver x receptor agonists: A method of increasing the ex vivo viability of pancreatic islet cells comprising contacting the islet cells with a liver X receptor (LXR) agonist, particularly an LXRalpha agonist. Examples of especially useful LXR agonists include GW3965 and T0901317.... Agent: Crowell & Moring LLP Intellectual Property Group

20100297760 - Pharmaceutical composition and a method for treatment of prostate cancer: The present invention is directed to pharmaceutical compositions and methods for treatment of prostate cancer in a subject. The pharmaceutical composition includes a therapeutically effective amount of compound mahanine, or derivatives, or analogues, or pharmaceutically acceptable salt thereof. The present invention is further directed to a method of isolating compound... Agent: Brinks Hofer Gilson & Lione

20100297762 - Photodynamic therapy using chemiluminescence and a ligand-photosensitiser conjugate: A method for destroying harmful cells is provided, applicable in treating proliferative diseases. The cells are destroyed by a combined treatment with a chemiluminescent agent and with a ligand-photosensitizer conjugate. The chemiluminescent agent emits light on reacting with oxygen species present in situ, the conjugate binds to the cell through... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100297763 - Conditionally immortalized long-term stem cells and methods of making and using such cells: Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse... Agent: Wilson, Sonsini, Goodrich & Rosati

20100297765 - Method for producing langerhans cells or interstitial dendritic cells or both from cd14+ monocytes: s

20100297764 - Use of a hydrogel for the culture of chondrocytes: The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.... Agent: Stites & Harbison PLLC

20100297766 - Method of removing undesired tissue from connective tissue: A method of removing undesired tissue from a connective tissue is provided that includes stretching the connective tissue and peeling away the undesired tissue. Some methods include soaking the connective tissue in a solution prior to and/or subsequent to stretching and peeling away the undesired tissue. The solution may include... Agent: Howrey LLP-hn

20100297767 - Novel cell culture and methods of producing and collecting cell masses using the same: The inventors of the present invention found that the above-mentioned objects could be attained by using a structural member having a hollow portion at least one lower end of which is open, creating a projecting portion of a culture medium at the open lower end of the structural member, and... Agent: Drinker Biddle & Reath (dc)

20100297768 - Nanofibrillar structure and applications including cell and tissue culture: A nanofibrillar structure for cell culture and tissue engineering is disclosed. The nanofibrillar structure can be used in a variety of applications including methods for proliferating and/or differentiating cells and manufacturing a tissue. Also disclosed is an improved nanofiber comprising a lipid, lipophilic molecule, or chemically modified surface. The nanofibers... Agent: Merchant & Gould PC

20100297769 - Centromere sequences and minichromosomes: The invention is generally related to methods of generating plants transformed with novel autonomous mini-chromosomes. Mini-chromosomes with novel compositions and structures are used to transform plants cells which are in turn used to generate the plant. Methods for generating the plant include methods for delivering the mini-chromosome into plant cell... Agent: Marshall, Gerstein & Borun LLP (chromatin)

20100297770 - Liquid-based method for producing plant embryos: The present invention relates to methods for developing embryos and producing germination-competent embryos using a liquid embryo development media.... Agent: Foley And Lardner LLP Suite 500

20100297771 - Method of ex vitro sowing, germination, growth and conversion of plant somatic embryos or germinants, and nutrient medium used therefor: A method of sowing a somatic plant embryo or germinant of a conifer species to facilitate subsequent development of the embryo or germinant into an autotrophic seedling. The method involves the following steps carried out ex vitro in non-sterile conditions: providing a nutrient medium comprising particles of a solid component... Agent: Kirby Eades Gale Baker

20100297773 - Expression cassette, use of the expression cassette, vector, host cell, a method for producing a polypeptide: The subject matters of invention relate to expression cassette, use of the expression cassette, vector, host cell, a method for producing a polypeptide ensuring its stable expression by the prokaryotic host as well as an use of the expression cassette. The invention enables stable expression of the target polypeptide, in... Agent: Walker & Jocke, L.p.a.

20100297772 - Method for the creation of genetic diversity in vivo: Disclosed is a method for creating genetic diversity in vivo, comprising the following steps: fragments of at least one wild-type gene sequence are produced, each of said fragments being provided with at least one region which is homologous with a vector that is suitable for in vivo recombination; randomized bridging... Agent: Henry M Feiereisen, LLC Henry M Feiereisen

  
11/18/2010 > patent applications in patent subcategories. recently filed with US Patent Office

20100291533 - Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect: The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage,... Agent: Birch Stewart Kolasch & Birch

20100291532 - Process for sterilizing acellular soft tissue with irradiation: e

20100291535 - Method using microfluidic chip to sort high motility sperm: The present invention discloses a method using a microfluidic chip to sort high motility sperm. In the present invention, sperm and a medium are respectively injected into a microchannel of a microfluidic chip via several inlets. Owing to the characteristic of microfluidics, the sperm and the medium form a sperm... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20100291534 - Methods and systems for isolating, ex vivo expanding and harvesting hematopoietic stem cells: Disclosed herein are methods and systems for isolating, ex vivo expanding and harvesting hematopoietic stem cells. Methods and systems described herein are easy to use, time-efficient, and allow isolation, ex vivo expansion and harvest of hematopoietic stem cells either batchly or continuously.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100291536 - Sample processing cassette, system, and method: The present invention provides a method and device for collecting treating and analysis of biological or chemical material by introducing a source material into a specimen container, transferring the source material to a processing device and thermally, chemically and/or mechanically treating the source material to alter at least one constitutive... Agent: Dobrusin & Thennisch PC

20100291545 - Antibody having inhibitory activity on infection with hepatitis c virus (hcv) and use thereof: The objection of the invention is to provide an antibody that inhibits infection with hepatitis C virus (HCV). To this end, this invention provides an antibody that recognizes the hepatitis C virus (HCV) particle obtained from the hepatitis C virus (HCV) genome comprising the following (i) and (ii) ligated to... Agent: Birch Stewart Kolasch & Birch

20100291538 - Artificial calibration virus to control hiv viral load tests by pcr in real time: The present invention refers to the design of an artificial calibrating virus (ACV), as well as a methodology quality guarantee system, which has controlling characteristics in the performance of all the stages carried out during a detection and/or quantification molecular test. More specifically, the referred to ACV is used for... Agent: Merek, Blackmon & Voorhees, LLC

20100291541 - Bacteriophage immobilization for biosensors: A method is disclosed for anchoring a bacteriophage on a substrate, the bacteriophage having a phage amine moiety, the method comprising: producing a free amine terminal moiety on the substrate by chemical modification of the substrate; activating the free amine terminal moiety with a cross-linking agent to produce an active... Agent: Lambert Intellectual Property Law

20100291540 - Carbohydrate binding module and use thereof: The present invention relates to an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also relates to a method of detecting HIV glycoprotein.... Agent: Wpat, PC Intellectual Property Attorneys

20100291544 - Compositions for use in identification of strains of hepatitis c virus: The present invention provides compositions, kits and methods for rapid identification and quantification of strains of hepatitis C viruses by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.

20100291547 - Fluorogenic hydrazine-substituted compounds: The present disclosure is directed to fluorogenic schiff base-forming dyes capable of detecting analytes containing aldehyde and ketone groups. The dyes contain nucleophilic hydrazinyl appendages and are capable of binding and detecting analytes in situ.... Agent: Life Technologies Corporation C/o Intellevate

20100291543 - Homogeneous in vitro fec assays and components: Reporter fragments, reporter components, and systems adapted to detect analytes in homogeneous in vitro assays are provided, such assays employing these systems, and methods of making and using same. Particular embodiments include isolated and purified reporter fragments displaying enhanced solubility, reduced aggregation, resistance to inhibitors, and enhanced suitability for use... Agent: Foley Hoag, LLP (w/isa) Patent Group

20100291546 - Method for detection of hepatitis b virus: To provide a method for detection or quantification of hepatitis B virus (HBV) antigens in serum and a simple and highly user-friendly method for sample treatment for use in the detection or quantification thereof. The method for treatment of a sample containing hepatitis B virus (HBV) is characterized in that... Agent: Birch Stewart Kolasch & Birch

20100291539 - Methodology for detection, enumeration, propagation and manipulation of bacteriophages: A method to propagate, enumerate and quantify bacteriophage(s) in a water sample or other aqueous sample was designed which contains ingredients to stimulate the growth of select bacterial species which are susceptible to infection by specific bacteriophage(s), in which interfering background organisms are either inhibited or inconsequential. Important features of... Agent: Botkin & Hall, LLP

20100291537 - Methods and compositions related to phage-nanoparticle assemblies: Embodiments of the invention include additional compositions and related methods and devices for the use of phage-nanoparticle assemblies. Embodiments of the invention include compositions, methods and devices related to phage-nanoparticle assemblies and their use in a variety of methods including detection methods, in vitro and in vivo diagnostic methods, direct... Agent: Fulbright & Jaworski L.L.P.

20100291542 - Rapid immunochromatographic detection by amplification of the colloidal gold signal: The present invention relates to a method for rapid immunochromatographic detection of a target in a sample by double sandwich immunoassay detection, wherein the target is an antibody and/or an antigen, using different colloidal gold conjugates conjugated with a first and a second specific antibody or antigen, respectively, to a... Agent: Patent Central LLC Stephan A. Pendorf

20100291581 - Aldehyde dehydrogenase 1 (aldh1) as a cancer stem cell marker: The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides a novel stem cell cancer marker, ALDH1, useful for the diagnosis, characterization, and treatment of solid tumor stem cells.... Agent: Casimir Jones, S.c.

20100291569 - Assay for prediction of response to met antagonists: A method for classifying cancer patients as likely to have lower response to MET receptor antagonist therapy comprises assessment of the presence or absence of a single nucleotide polymorphism in the MET promoter in a patient tissue sample. The invention provides more effective identification of patients to receive MET receptor... Agent: Abbott Gmbh C/o Polsinelli Shughart PC

20100291563 - Assessing tissue rejection: This document relates to methods and materials involved in assessing tissue rejection (e.g., organ rejection) in mammals. For example, methods and materials involved in detecting tissue rejection (e.g., kidney rejection) are provided, as are methods and materials for determining the extent of rejection in mammals (e.g., humans).... Agent: Fish & Richardson P.C.

20100291557 - Binary probe and clamp composition and methods for target hybridization detection: Binary probe and clamp compositions conduct methods for target hybridization detection. Where the probe is a substrate for exonuclease cleavage, the composition provides quantitation and detection of PCR products, by real-time and end-point measurements. Where the probe is an amplification primer, the composition provides an improved method for labelling and... Agent: Life Technologies Corporation C/o Intellevate

20100291580 - Biomarkers for trichogenicity: Biomarkers for identifying trichogenic cells have been identified. The biomarkers include microRNA as wells as mRNA and proteins. Certain biomarkers are upregulated in trichogenic cells compared to non-trichogenic cells; whereas, other biomarkers are down-regulated in trichogenic cells compared to non-trichogenic cells. The cells can be dermal cells, epidermal cells, or... Agent: Pabst Patent Group LLP

20100291554 - Compositions and methods for determining genotypes: The present invention provides methods for determining the genotype of a selected gene present in at least two alleles in a sample. The methods involve amplifying DNA from the sample with a first pair of flanking primers that hybridize to nucleic acid sequences flanking a variant-specific gene sequence, the presence... Agent: Foley & Lardner LLP

20100291559 - Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing... Agent: Quine Intellectual Property Law Group, P.C.

20100291575 - Detection of changes in cell populations and mixed cell populations: The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100291582 - Detection of group b streptococcus: The invention provides methods to detect group B streptococcus (GBS) in biological samples using real-time PCR. Primers and probes for the detection of GBS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GBS are further provided by the invention.... Agent: Fish & Richardson P.C.

20100291565 - Detection of methylation in nucleic acid sequences: The present invention provides a method for detecting and/or quantifying the presence of, and relative abundance of, methylated nucleic acid bases within double-stranded nucleic acid by i) contacting a double-stranded nucleic acid sample with an intercalating fluorescent dye when bound to the nucleic acid sample fluoresces when exposed to light... Agent: Dann, Dorfman, Herrell & Skillman

20100291552 - Detection of mutations in a gene encoding ikb kinase-complex-associated protein to diagnose familial dysautonomia: A method for detecting the presence in a subject of a polymorphism linked to a gene associated with familial dysautonomia, said method comprising detecting a disruptive mutation in a gene of said subject encoding the IκB kinase-complex-associated protein, and, preferably, detecting a T→C change in position 6 of the donor... Agent: Scully Scott Murphy & Presser, PC

20100291571 - Diagnosis of fetal aneuploidy by quantification of genomic dna from mixed samples: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a... Agent: Wilson, Sonsini, Goodrich & Rosati

20100291578 - Droplet-based pyrosequencing: The present invention relates to droplet-based pyrosequencing including a method of identifying a base at a target position in a sample nucleic acid. The method includes: (a) providing a droplet microactuator including a first droplet including a sample nucleic acid immobilized on a bead; and (b) on the droplet microactuator:... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20100291572 - Fetal aneuploidy detection by sequencing: The present invention provides apparatus and methods for enriching components or cells from a sample and conducting genetic analysis, such as SNP genotyping to provide diagnostic results for fetal disorders or conditions.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100291551 - Genemap of the human associated with crohn's disease: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility... Agent: Dowell & Dowell P.C.

20100291567 - Genes and polypeptides relating to hepatocellular or colorectal carcinoma: The present application provides novel human genes WDRPUH and KRZFPUH, and PPIL1 whose expression is markedly elevated in a great majority of HCCs and colorectal cancers, respectively, compared to corresponding non-cancerous tissues, as well as novel human gene APCDD1 whose expression is elevated in primary colon cancers and down-regulated in... Agent: Townsend And Townsend And Crew, LLP

20100291574 - Genotyping assay to predict gamma glutamyl hydrolase (ggh) activity: Single nucleotide polymorphisms (SNPs) in the gene encoding gamma glutamyl hydrolase (GGH) associated with reduced GGH activity are disclosed. The primary SNP is a change from a cytosine to a thymine at a position corresponding to nucleotide 511 of Genbank sequence accession no. NM 003878. Methods and kits for detecting... Agent: J. Scott Elmer St. Jude Children's Research Hospital

20100291576 - Imprinted genes as epigenetic markers for use in cloning and regenerative cell procedures: In general, the invention features methods of identifying and/or preparing a mammalian cell or a cell population (e.g., bovine or porcine cells) for use in cloning procedures or regenerative cell procedures using expression of one or more of the epigenetic markers, IGF2, p57, and NNAT.... Agent: Clark & Elbing LLP

20100291556 - Isolated aebp1 genomic polynucleotide fragments from chomosome 7 and their uses: The invention is directed to isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD regulatory subunit (POLD2), vectors and hosts containing these fragments and fragments hybridizing to noncoding regions as well as antisense oligonucleotides to these fragments.... Agent: Cheryl H Agris Phd

20100291558 - Magnetic particles for nucleic acid sequencing and method of sequencing nucleic acid using the same: Provided are magnetic particles for nucleic acid sequencing and a method of sequencing nucleic acid using the same. The nucleotide sequence of a target nucleic acid may be efficiently determined using the magnetic particles and the method of sequencing nucleic acid using the same.... Agent: Cantor Colburn LLP

20100291570 - Materials and methods for detection of nucleic acids: Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second primers; amplifying the target nucleic acid by PCR using the first and second primers to generate an amplification product having a... Agent: Eragen Biosciences, Inc. C/o Foley & Lardner LLP

20100291562 - Method for the detection of an analyte in biological matrix: The present invention relates to a method for the highly sensitive Immuno-PCR detection of an analyte in a sample comprising the use of a nucleic acids containing sample dilution buffer for diluting the sample as well as methods for the preparation of the sample dilution buffer and the use thereof.... Agent: Biotechnology Law Group 12707 High Bluff Drive

20100291585 - Methods and compositions for diagnosing complications of pregnancy: The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.... Agent: Foley And Lardner LLP Suite 500

20100291549 - Methods and compositions for antibody therapy: Methods and materials are provided for determining the responsiveness of a subject to a therapy, such as an antibody therapy and for selecting and/or for treating a subject based on a FcγRIIA polymorphism, or a FcγRIIIA polymorphism, or both an FcγRIIA polymorphism and a FcγRIIIA polymorphism, including where the treatment... Agent: K&l Gates LLP

20100291560 - Methods and compositions for diagnosis and treatment of dyskeratosis congenita and related disorders: The present invention features methods of detection, diagnosing a presence or a predisposition to, or determining the risk for a subject to develop telomere-associated diseases or disorders. The methods include detecting the presence or absence of an alteration in a nucleic acid in a sample. The methods also include determining... Agent: Edwards Angell Palmer & Dodge LLP

20100291550 - Methods and compositions for modulating hair growth: The invention relates, in part, to methods and compounds that are useful to modulate hair growth in mammals. The invention, in part, also includes nucleic acids, polypeptides, and genetic constructs that may be used to diagnose and treat hair growth disorders, for screening for compounds that modulate hair growth, and... Agent: Wolf Greenfield & Sacks, P.C.

20100291561 - Methods for detecting a target nucleotide sequence in a sample utilising a nuclease-aptamer complex: The present invention relates to methods for detecting a target nucleotide sequence in a sample. More particularly, the present invention relates to methods for detecting a target nucleotide sequence in a sample which utilise a nuclease-aptamer complex. The present invention also provides nuclease-binding aptamers, nuclease-aptamer complexes and linker molecules that... Agent: Townsend And Townsend And Crew, LLP

20100291583 - Methods for detecting nucleic acids using multiple signals: Disclosed is are methods for identifying a nucleic acid in a sample. In one example, the method includes: (a) contacting the nucleic acid in the sample with an oligonucleotide that is specific for the nucleic acid in the sample and that is labeled with at least a first fluorescent dye;... Agent: Foley & Lardner LLP

20100291564 - Methods for detection of micro-organisms: NAD-dependent ligase is identified as an indicator of micro-organisms in a sample. A method of detecting the presence of an NAD-dependent ligase expressing micro-organism in a sample comprises the steps of: (a) contacting the sample with a nucleic acid molecule which acts as a substrate for NAD-dependent ligase activity in... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100291568 - Methods for genetic analysis of dna to detect sequence variances: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.... Agent: Fish & Richardson PC

20100291548 - Methods of detecting target nucleic acids: The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating the modified coded molecules from the unmodified coded... Agent: Life Technologies Corporation C/o Intellevate

20100291573 - Methods of predicting cancer risk using gene expression in premalignant tissue: The present disclosure provides methods for assessing a patient's cancer risk and/or recurrence risk, which methods comprise assaying, in a biological sample obtained from the gastrointestinal (GI) tract of the patient, an expression level of a risk gene. The present disclosure also provides methods involving a cancer risk/recurrence risk sequence,... Agent: Genomic Health, Inc. (bozicevic, Field & Francis) C/o Kathleen Determann

20100291584 - Microfluidic imaging cytometry: A microfluidic system has a pipette system comprising a plurality of pipettes, a microfluidic chip arranged proximate the pipette system, an imaging optical detection system arranged proximate the microfluidic chip, and an image processing system in communication with the imaging optical detection system. The microfluidic chip has a plurality of... Agent: Venable LLP

20100291579 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses: The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the... Agent: Millennium Pharmaceuticals, Inc.

20100291553 - Nucleic acid strand useful in detecting substance and method thereof: To detect an infinitesimal substance with a high sensitivity without amplifying the infinitesimal substance. A nucleic acid strand for detection P having at least a fluorescent substance F which can serve as a donor of resonance excitation energy (fluorescence resonance energy), a quencher substance Q which is located at a... Agent: K&l Gates LLP

20100291555 - Primer and probe for detection of mycobacterium avium and method for detection of mycobacterium avium by using the primer or probe: The object of the present invention is to provide a novel primer for use in the detection of Mycobacterium avium (M. avium), and a method for detection of M. avium conveniently, rapidly and with high precision by using the primer. More specifically, disclosed are an oligonucleotide which comprises a part... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100291566 - Systems and methods for diagnosis and monitoring of bacteria-related conditions: The presently-disclosed subject matter provides systems, methods, and kits for diagnosing and/or monitoring a bacteria-related condition of interest in a subject by providing a cell sensing system, each system containing a reporter molecule capable of detecting binding of a quorum sensing molecule and capable of generating a detectable signal.... Agent: Stites & Harbison PLLC

20100291577 - Toll-like receptor 9 modulators: TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of... Agent: Fish & Richardson PC

20100291587 - Biomarker for diagnosing heart disease and the use thereof: [3] A method for detecting severity of heart disease, characterized in that the method comprises determining a free immunoglobulin kappa light chain level and/or a free immunoglobulin lambda light chain level of a specimen and comparing at least one value of the kappa chain level, the lambda chain level, and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100291586 - Method for the diagnosis or the screening of an arbovirus infection, reagents useful in said method and their applications: Method for the diagnosis or the screening of an arbovirus infection and preferably a flaviviridae infection and more preferably a flavivirus infection, reagents useful in said method and their applications. Said method comprises: (i) contacting a sample from the subject or animal with a solid support sensitized with an Ig... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100291589 - Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level: The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the... Agent: Fish & Richardson P.C.

20100291588 - Systems and methods including self-contained cartridges with detection systems and fluid delivery systems: Methods, systems, and apparatus for detecting the presence of analytes are described. A fluid or gas sample may pass through a microsieve-based detection system and/or a particle-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the identity and quantity of the captured analytes.... Agent: Fulbright & Jaworski L.L.P.

20100291594 - Erbb surface receptor complexes as biomarkers: The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers... Agent: Kilpatrick Stockton LLP

20100291593 - Method of identifying diagnostic reagents: Disclosed herein are methods for identifying diagnostic reagents (e.g., antigen-binding molecules, such as antibodies) that are useful, for instance, as primary diagnostic, prognostic, and/or predictive (e.g., companion diagnostic) reagents in a disease state, such as cancer.... Agent: Klarquist Sparkman, LLP

20100291592 - Novel marker for sensitivity against sulfonamide compound: The sensitivity of a tumor cell to a sulfonamide compound or the anti-tumor effect of a sulfonamide compound can be examined by determining the expression level of EGFR1 in the tumor cell and employing the variation in the EGFR1 expression level as a measure. Thus, a method for determination of... Agent: Birch Stewart Kolasch & Birch

20100291595 - Blood monocyte cd163 expression as a biomarker in hiv-1 infection and neuroaids: The invention provides a method for detecting CD163+/CD16+ cell population in peripheral blood mononuclear cells in a biological sample from a subject infected with HIV-1 which comprises contacting the biological sample with an anti-CD163 antibody, so that levels of CD163+/CD16+ peripheral blood mononuclear cells in the biological sample can be... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20100291596 - Screening method for agents suitable for therapy of alzheimer's disease: Described is a method of screening for therapeutic agents for the prophylaxis and therapy of Alzheimer's disease (AD), wherein agents that (i) do not interfere with the biological activity of gamma-secretase, (ii) do not exhibit cytotoxicity, (iii) lead to reduced amounts of Abeta42 and (iv) are capable of binding to... Agent: Intellectual Property / Technology Law

20100291590 - Methods for the diagnosis and the prognosis of a brain tumor: The present invention relates to methods for the diagnosis of a brain tumor and for the estimation of a prognosis for patients having a brain tumor using the presence/absence of a particular IDH1 mutation as a marker.... Agent: Moore & Van Allen PLLC

20100291591 - Novel plating media: Plating media contains enzyme substrates (ES) used to detect enzyme activity associated with a target organism and that include a binding motif (BM) that serves to bind detectable enzymes (DE) (also called marker enzymes in this disclosure). A signalogenic substructure (SG) produces detectable signals and an enzyme labile group (ELG)... Agent: Life Technologies Corporation C/o Intellevate

20100291601 - Carbohydrate binding module and use thereof: The present invention relates to an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also relates to a method of detecting HIV glycoprotein.... Agent: Wpat, PC Intellectual Property Attorneys

20100291602 - Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers: The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Plasma from patients with hepatic cirrhosis induced by infection... Agent: Foley And Lardner LLP Suite 500

20100291600 - Immunoassay: The present invention provides an immunoassay method for detecting or determining the amount of salvinorin A, salvinorin B and/or analogues thereof in an in vitro sample, an antibody for salvinorin A, salvinorin B and/or analogues thereof and a kit for detecting the presence of or determining the amount of salvinorin... Agent: Oliff & Berridge, PLC

20100291599 - Large area scanning apparatus for analyte quantification by surface enhanced raman spectroscopy and method of use: Raman spectra of protein immunoblots or enzyme linked immunosorbant assay procedures are acquired with a scanning Raman spectrometer. The sensitivity of the measurement is increased by conjugating secondary antibodies used in the Western blot and ELISA methods to surface enhanced Raman Scattering (SERS) labels. The resulting blot or well plate... Agent: Law Offices Of Paul E. Kudirka

20100291598 - Prion elisa: Assays for detecting PrPSc in a sample are described. In particular, pathogenic prion ELISAs are described. The assays utilize pathogenic prion-specific reagents to capture the PrPSc and digestion with a site-specific protease, for example trypsin or SV-8 protease, to reduce the amount of interference from non-pathogenic prion proteins that are... Agent: Novartis Vaccines And Diagnostics Inc.

20100291597 - Secretogranin and vgf peptide biomarkers and uses thereof: Secretogranin II and VGF peptides are biomarkers for major depressive disorder. They are useful in methods of diagnosing, monitoring and screening.... Agent: Foley And Lardner LLP Suite 500

20100291603 - Assessing blood components: This document relates to methods and materials involved in assessing blood components (e.g., assessing von Willebrand factor activity or platelet activity) in mammals. For example, methods and materials involved in using labeled platelets to assess von Willebrand factor activity in a sample (e.g., plasma) from a mammal (e.g., a human)... Agent: Fish & Richardson P.C.

20100291604 - Predictive treatment of dysglycemic excursions associated with diabetes mellitus: A predictive technique for treating diabetes mellitus is described whereby a patient's blood glucose levels are monitored “continuously” over an extended period of time and a life-event diary is maintained records all significant life-events (e.g., food intake, medication, exercise, mood/emotions, etc.). This information is analyzed to derive a mathematical model... Agent: Howard M Cohn Patent Attorney LLC

20100291605 - Assays for s-adenosylmethionine-dependent methyltransferases: Disclosed are novel methyltransferase assay methods, comprising: including, in a reaction mixture for a methyltransferase activity, a purified or recombinant adenosine nucleosidase activity that catalyses release of an adenine or adenine derivative moiety from a transmethylation product, and a purified or recombinant adenine deaminase activity that catalyses deamination of the... Agent: Davis Wright Tremaine, LLP/seattle

20100291606 - Screening system for detecting inhibitors of hiv integrase-ledgf/p-75 interaction: The development and validation of a cell-based, homogeneous high throughput screening (HTS) assay for small compounds inhibiting the HIV integrase-LEDGF/p75 interaction is described herein. The HTS strategy has the potential to identify small-molecules interfering with the interaction of HIV integrase-LEDGF/p75. These small molecules represent starting scaffolds for therapeutic drug development.... Agent: Chalker Flores, LLP

20100291607 - Transformed cell with enhanced sensitivity to antifungal compound and use thereof: The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at least one hybrid-sensor kinase, a method of assaying the... Agent: Sughrue Mion, PLLC

20100291608 - Novel gtp cyclohydrolase type ib: This invention relates to a novel, bacterial GTP Cyclohydrolase Type IB enzyme, and the crystal structure thereof.... Agent: J.a. Lindeman & Co. PLLC

20100291609 - Reducing optical interference in a fluidic device: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces... Agent: Wilson, Sonsini, Goodrich & Rosati

20100291611 - Assays: A device includes a substrate that defines, at least in part, a microfluidic network including an inlet in communication with a first detection zone and with a second detection zone. A cobalt reagent and a nickel reagent are disposed within the microfluidic network. First electrodes are in communication with the... Agent: Steptoe & Johnson LLP

20100291614 - In vitro method for determining the risk of and diagnosis of an arterial vascular disorder: An in vitro method is disclosed for (i) determining the risk to an individual of developing an arterial vascular disorder, or (ii) diagnosing an arterial vascular disorder. In at least one embodiment, the method includes at least the following: (a) determining at least one biomarker characteristic of a vascular disorder... Agent: Harness, Dickey & Pierce, P.L.C

20100291613 - Method of positioning an organic, biological and/or medical specimen: The invention relates to a method of positioning an organic, biological and/or medical specimen in a desired partial region of a specimen carrier, comprising the steps arrangement of a gel in a partial region of the specimen carrier, polymerisation or gelification of the gel, by means of which a polymerised... Agent: Ip Strategies

20100291616 - Novel genes, compositions, kits, and methods for identification, assessment, prevention and therapy of cervical cancer: The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.... Agent: Mccarter & English, LLP Boston

20100291612 - Peptide markers for diagnosis of preeclampsia: The present invention relates to a method for detecting preeclampsia, comprising determining the expression level of calcyclin in chorionic villi. The invention further relates to a marker for detecting preeclampsia wherein said marker is calcyclin.... Agent: Swanson & Bratschun, L.L.C.

20100291610 - Regulating stem cells: A composition of matter is provided, comprising a population of cultured cells that comprises a sub-population of cells that both stain as CD31Bright and demonstrate uptake of Ac-LDL+, and secrete IL-8. A method is also provided, comprising stimulating in vitro an initiating cell population (ICP) of at least 5 million... Agent: Cooper & Dunham, LLP

20100291615 - System and method for automatically venting and sampling a culture specimen container: Apparatus for automated venting and/or sampling of a specimen container having a closure sealing the interior of the specimen container from the environment is disclosed. The apparatus includes a rack holding the specimen container; a venting and/or sampling device having a needle, a chamber in fluid communication with the needle... Agent: Biomerieux Vitek Inc.

20100291619 - Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample: A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification... Agent: Biomerieux Vitek Inc.

20100291618 - Methods for rapid identification and/or characterization of a microbial agent in a sample: A method of testing a specimen sample contained within a sealed specimen container. A test sample is removed from the specimen container with a disposable sampling device. Non-microbial agent components of the test sample are lysed, thereby producing a lysed sample. The lysed sample is delivered to a disposable separation... Agent: Biomerieux Vitek Inc.

20100291617 - Rapid detection of volatile organic compounds for identification of mycobacterium tuberculosis in a sample: In various embodiments, the invention relates to a method for identifying the presence of particular bacteria in a sample. The method includes collecting a sample that includes or has been exposed to the particular bacteria and detecting, in the sample, at least one volatile organic compound indicative of the presence... Agent: Goodwin Procter LLP Patent Administrator

20100291621 - Anaerobic process: An anaerobic process uses a continuous oscillatory flow reactor (1) having a reaction tube with baffles (7) along its length. Fluid material is introduced into the tube through a circulating loop (41) and control valve (28) configuration. The fluid comprises the following components: a finely divided substrate material, e.g. of... Agent: Dykema Gossett PLLC

20100291620 - Bio-fuel production system: A biological material production system having an enclosure; a plant advancer located within th enclosure, the plant advancer configured to move one or more plants from a first position to a second position in a predetermined path; and at least one harvester positionable proximate the second position and configured to... Agent: Morgan, Lewis & Bockius LLP

20100291622 - Novel compound, process for production thereof, and use thereof: b

20100291623 - Process for producing alpha-glycosylated dipeptide and method of assaying alpha-glycosylated dipeptide: The present invention relates to a method for producing α-glycated dipeptide, which comprises causing protease to act on N-terminal-glycated peptide or N-terminal-glycated protein. The present invention further relates to a method for determining the amount of α-glycated dipeptide, which comprises causing a fructosyl peptide oxidase to act on the α-glycated... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100291624 - Compositions and methods for improved glycoprotein sialylation: The present invention provides compositions and methods for the production of glycoproteins with enhanced sialylation. In particular, the invention provides cell lines comprising disrupted sialidase expression and methods of using the cell lines to produce glycoproteins with enhanced sialylation.... Agent: Polsinelli Shughart PC

20100291626 - Enhanced expression and stability regions: Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for... Agent: Regeneron Pharmaceuticals, Inc

20100291625 - Regulation of translation of heterologously expressed genes: The present invention pertains to a method of expressing a protein of interest, preferably a heterologous protein, in preferably a plant. In a preferred embodiment said plant is a doubled haploid homozygous transgenic Nicotiana tabacum plant silenced for Ntp303. Furthermore, the invention relates to said plant with or without nucleic... Agent: Ballard Spahr LLP

20100291628 - Cells in which activity of the protein involved in transportation of gdp-fucose is reduced or lost: A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies... Agent: Sughrue-265550

20100291627 - Method for production of antibody: Disclosed is a method of producing an antibody or a fragment thereof, comprising allowing a cell to produce the antibody or the fragment, wherein the cell contains a larger number of copies of an exogenous DNA encoding the light chain or a fragment thereof of the antibody than the number... Agent: Foley And Lardner LLP Suite 500

20100291629 - Use of deleucocytation filters for defensin purification: The invention concerns the use of deleucocytation filters for defensin purification. More precisely, the invention concerns a method for purifying defensins, including the following steps: passing a blood sample on a deleucocytation filter; detaching the cells retained on the deleucocytation filter, inducing exocytosis of the defensins by those cells.... Agent: Cantor Colburn LLP

20100291630 - Method for producing a foaming agent: A method for producing a foaming agent is provided, the method comprising cultivating a host cell in a fermentation medium wherein the host cell extra-cellularly secretes a foaming agent and wherein the fermentation medium contains an antifoam which has a cloud point; and then removing the antifoam5 while the temperature... Agent: Unilever Patent Group

20100291631 - Novel beta-galactoside-alpha 2,3-sialyltransferase, a gene encoding thereof, and a method for producing thereof: The present invention provides a novel β-galactoside-α2,3-sialyltransferase and a nucleic acid encoding the sialyltransferase. The present invention also provides a microorganism producing the sialyltransferase, as well as a method for producing the sialyltransferase using such a microorganism. The present invention further provides a vector carrying a nucleic acid encoding the... Agent: Birch Stewart Kolasch & Birch

20100291632 - Method for the production of cladribine: e

20100291633 - Method of cloning at least one nucleic acid molecule of interest using type iis restriction endonucleases, and corresponding cloning vectors, kits and system using type iis restriction endonucleases: The present invention refers to methods of (sub)cloning at least one nucleic acid molecule of interest. One embodiment relates to a method of (sub)cloning at least one nucleic acid molecule of interest comprising a) providing at least one (replicable) Entry vector into which the at least one nucleic acid molecule... Agent: Biotechnology Law Group 12707 High Bluff Drive

20100291634 - Annealing control primer and its uses: The present invention relates to an annealing control primer for improving annealing specificity in nucleic acid amplification and its applications to all fields of nucleic acid amplification-involved technology. The present primer comprises (a) a 3′-end portion having a hybridizing nucleotide sequence substantially complementary to a site on a template nucleic... Agent: Miles & Stockbridge PC

20100291635 - Chimeric primers for improved nucleic acid amplification reactions: Methods are provided for amplification of a nucleic acid sequence. The method use RNA/DNA chimeric oligonucleotides as primers. The primers have RNA residues scattered along their length and no two ribonucleotides in the prime are adjacent to one another. The methods are useful for reducing non-specific amplification products, such as... Agent: Fennemore Craig

20100291636 - Method for introducing common and/or individual sequence elements in a target nucleic acid molecule: The invention relates to a method for introducing common and/or individual sequence elements in a target nucleic acid molecule in a sample containing sample nucleic acid molecules, comprising the steps: i) denaturing the sample nucleic acid molecules, if the sample nucleic acid molecules are double-stranded, to obtain single stranded sample... Agent: Knobbe Martens Olson & Bear LLP

20100291637 - Method for modifying nucleotide chain: A method for modifying a nucleotide chain, which includes: allowing a catabolic enzyme specific to a nucleotide sequence containing a specific base such as hypoxanthine (Hx) to act on a nucleotide chain (I) to be modified having the above described nucleotide sequence containing a specific base on the 3′-terminal side... Agent: Steptoe & Johnson LLP

20100291638 - Thermostable dna polymerases and methods of use: Thermostable viral and microbial polymerases exhibiting a combination of activities selected from proofreading (3′-5′) exonuclease activity, nick translating (5′-3′) nuclease activity, synthetic primer-initiated polymerase activity, nick-initiated polymerase activity, reverse transcriptase activity, strand displacement activity, terminal transferase activity, primase activity, and/or efficient incorporation of chain terminating analogs. Some of the polymerases... Agent: Intellectual Property Dept. Dewitt Ross & Stevens Sc

20100291639 - Chemical cavitation and cleaning process: Cavitation is an often used mechanism for accelerating chemical reactions and for cleaning purposes. This invention describes a very simple process for generating cavitation with a vibration table through vertical excitations which generates a “water hammer” that generates very effective cavitation. A simple example is given for an industrial application... Agent: Heiko Ackermann

20100291641 - Process for continuously preparing urethane-containing (meth)acrylic esters: A process for preparing urethane-containing (meth)acrylic esters (U) by reacting a urethane-containing alcohol (A) with a (meth)acrylic ester of a saturated alcohol (G) in the presence of at least one polymerization inhibitor (P) with an enzyme (E) as a catalyst in a reactor, wherein the (meth)acrylic ester of a saturated... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100291642 - Process for preparing dipeptidyl peptidase iv inhibitors and intermediates therefor: p

20100291640 - Process for preparing urethane-containing (meth)acrylic esters:

20100291643 - Method for producing enationmerically pure d-ppt: A method of producing enantimoerically pure D-Phosphinothricin (D-PPT) by providing a mixture of D and L PPT, N-acetylating L-PPT and then recovering and purifying D-PPT.... Agent: Syngenta Biotechnology, Inc. Patent Department

20100291644 - Process for preparing methacrylic acid or methacrylic esters: m

20100291645 - Xylose reductase mutants and uses thereof: Engineered mutant xylose reductases demonstrate higher preference to xylose than arabinose. Amino acid mutations were engineered in to native xylose reductase from Neurospora crassa. Mutant xylose reductases are useful in the production of xylitol and ethanol.... Agent: Barnes & Thornburg LLP

20100291647 - Microorganisms having enhanced resistance to acetate and related compositions and methods of use: The present invention provides isolated or genetically modified strains of microorganisms that display enhanced resistance to acetate as a result of increased expression of a sodium proton antiporter. The present invention also provides methods for producing such microbial strains, as well as related promoter sequences and expression vectors. Further, the... Agent: Scully Scott Murphy & Presser PC

20100291646 - Process for the recovery of a fermentation product: The present invention provides a process for the purification and concentration of a partially water-soluble organic product from a source containing the same at concentration C0, which process comprises the steps of: (i) concentrating said product by means of a resin to form a first aqueous solution at concentration of... Agent: Townsend And Townsend And Crew, LLP

20100291649 - Control of contaminant yeast in fermentation processes: A fermentation process for the production of ethanol from natural sources, such as corn, comprising introducing a fermentable sugar, an inoculant yeast, and a stabilized chlorine dioxide into a fermentation system is disclosed. The stabilized chlorine dioxide is added preventatively to the fermentation system to substantially prevent growth of contaminating... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100291648 - Global transcription machinery engineering: The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes.... Agent: Wolf Greenfield & Sacks, P.C.

20100291650 - Methods for reducing enzyme consumption in second generation bioethanol fermentation in the presence of lignin.: Provided are methods of liquefaction, saccharification and fermentation of pre-treated lignocellulosic biomass in production of bioethanol. Addition of PEG or surfactant is effective to enhance cellulase hydrolysis yields at high dry matter (>20%) at surprisingly low concentrations compared with comparable results in low dry matter hydrolysis. This effect is most... Agent: Plougmann & Vingtoft A/s

20100291651 - Recombinant hydrogen-producing cyanobacterium and uses thereof: A recombinant cyanobacterium comprising an oxygen-tolerant, hydrogen-evolving hydrogenase, kit, and methods of use.... Agent: Synthetic Genomics C/o Mofo

20100291653 - Biotransformation using genetically modified candida: A substantially pure Candida host cell is provided for the biotransformation of a substrate to a product wherein the host cell is characterized by a first genetic modification class that comprises one or more genetic modifications that collectively or individually disrupt at least one alcohol dehydrogenase gene in the substantially... Agent: Jones Day

20100291652 - Yeast strains and methods of making and using such yeast strains: The present disclosure provides genetically-modified yeast that are able to produce more ethanol and less glycerol than yeast lacking the corresponding genetic modifications. The approaches described herein involve disrupting the ability of the yeast to produce and/or transport glycerol and increasing the amount of a polypeptide involved in maintaining the... Agent: Townsend And Townsend And Crew, LLP

20100291654 - Preparation for photodynamic control of microorganisms and use thereof: The invention relates to a preparation for the photodynamic control of micro-organisms, said preparation being in a liquid or pasty form and containing a photosensitiser which comprises a dyestuff and produces singlet oxygen when irradiated by means of light. The micro-organisms can be marked by means of the dyestuff. The... Agent: Jordan And Hamburg LLP

20100291655 - Novel glucose dehydrogenase and method for producing the dehydrogenase: A novel glucose dehydrogenase, which is an enzyme that has high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is obtained by culturing a microorganism belonging to the genus Burkholderia and having... Agent: Knobbe Martens Olson & Bear LLP

20100291656 - Method and system for protein purification: The present invention provides a method and a system for protein purification using a starch binding protein (SBP)-tagged recombinant protein. SBP-binding matrixes are also disclosed in the invention to recover the SBP-tagged recombinant protein. Thus, purifying a target protein is re-usable, convenient and low cost by the present invention.... Agent: Wpat, PC Intellectual Property Attorneys

20100291657 - Ribonucleases in which an amino acid sequence of a known ribonuclease is preceded by at least one residue at the n-terminus, and methods of making them recombinantly: New RNases, and methods of making them, are disclosed. Each includes an amino acid sequence that is disclosed in U.S. Pat. No. 6,239,257 B1, but that is preceded by a different N-terminus residue or leader sequence.... Agent: Mark H. Jay, P.A.

20100291659 - Methods and apparatuses for reducing emissions of volatile organic compounds from pumps and storage tanks for voc-containing fluids: A method is provided for reducing emissions of a volatile organic compound (“VOC”) from a source of the VOC. The method includes the steps of: (A) operatively positioning a VOC-absorbing material between the source of the VOC and the atmosphere, wherein the VOC from the source of the VOC must... Agent: Booth Albanesi Schroeder LLC

20100291658 - Process for separating nonproteinaneous biomolecules, in particular nucleic acids, from proteinaneous samples: The present invention relates to method of isolating non-protein-containing biomolecules, in particular nucleic acids, characterized in that protein degradation is carried out on a solid phase.... Agent: Fanelli Strain & Haag PLLC

20100291660 - Method of staggered release or exposure of microorganisms for biological remediation of hydrocarbons and other organic matter: A methodology, and related systems and structures for accomplishing the methodology, of biological remediation of hazardous or undesirable organic matter, wherein a plurality of carrier members are disposed in a localized retaining member, the carrier members releasing or exposing microorganisms to the undesirable organic matter on a staggered basis over... Agent: Rogers Towers, P.A.

20100291661 - Method of removing harmful substances: [Means for Solution] A method for removing toxic substance from gas comprising: primary step B for releasing the gas from which an internal combustion engine and an incinerator (A) exhausted in liquid S which contained a microbe comprising the cell body group including the photosynthesis bacteria and a microbe comprising... Agent: Cowan Liebowitz & Latman P.c

20100291662 - Container for the preparation, preservation and storage of biological samples using a drying agent: The invention relates to a sample container (10, 100, 500, 700) for biological sample material (23, 230), comprising an upper opening (11) that can be closed by a lid (14, 140, 540), a lateral wall region (12) and a base (13) and a hygroscopic substance (19, 190, 590, 790) contained... Agent: Rankin, Hill & Clark LLP

20100291663 - Culture apparatus: The present invention relates to a culture apparatus that enables cells to be observed and dispensed without damaging the cells. An internal space of an incubator unit is provided with a dispensing area for arranging dispensers for dispensing into a culture vessel, an observation area for arranging an observation unit... Agent: Oliff & Berridge, PLC

20100291664 - Laboratory apparatus with incubator: Laboratory apparatus comprises at least one cabinet; at least one incubator; at least one transfer hatch; and means for circulating air within the apparatus, wherein the at least one cabinet is connected to an incubator and a transfer hatch; wherein the at least one incubator comprises at least two discrete... Agent: Macmillan Sobanski & Todd, LLC

20100291665 - Biocompatible three dimensional matrix for the immobilization of biological substances: The present invention relates to a method of producing a solid coated carrier carrying biological material. Furthermore, the invention relates to a solid coated carrier to which biological material is attached and uses of the solid coated carrier for the preparation of a medical product. Moreover, the invention provides a... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100291668 - Apparatus for performing amplicon rescue multiplex pcr: The present disclosure is a cassette for PCR amplification and detection of DNA amplicons, the cassette having a cassette pipette which may be moved vertically and horizontally within the cassette, at least one reagent chamber, and at least one detector, such as a microarray, for the detection of DNA amplified... Agent: Lanier Ford Shaver & Payne P.C.

20100291666 - Molecular diagnostics system and methods: The present invention relates to automated devices and methods for the extraction of nucleic acids from cells, the amplification of segments of nucleic acid and the detection of nucleic acids, all in a convenient and portable manner. The invention is particularly suited for use in point-of-care medical diagnostic testing.... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20100291667 - Optical detector: Disclosed herein is an optical detector at least including: a first substrate in which a plurality of wells are formed; a second substrate in which a heating section is provided to heat the wells; a third substrate in which a plurality of photoirradiation sections are provided in alignment with the... Agent: K&l Gates LLP

20100291669 - System for rapid identification and/or characterization of a microbial agent in a sample: An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative... Agent: Biomerieux Vitek Inc.

20100291670 - Method for detecting candida on skin: A method and system for rapidly detecting Candida on the skin of a host, such as an infant with diaper rash, is provided. The method includes contacting a dermal sample with a colorant that exhibits a certain spectral response (e.g., color change) in the presence of Candida. For example, the... Agent: Dority & Manning, P.A.

20100291671 - Modified viral vector particles: This invention relates to viral vector particles, including capsid proteins with an attachment site for the specific chemical modification of the vector particles. Furthermore, the invention relates to procedures for the production of these viral vector particles. Furthermore, the invention relates to the use of these viral vector particles as... Agent: Fulbright & Jaworski L.L.P.

20100291673 - Alternative export pathways for vector expressed rna interference: The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules.... Agent: Viksnins Harris & Padys Pllp

20100291674 - Disposable bioreactor, kit for the same and method for its production: The present invention discloses a disposable bioreactor, consisting of a container and a cap, which is connectable to the same and cannot be detached without destruction. For this purpose, the cap comprises a retaining structure with a plurality of locking arms running in the lateral direction, while the locking arms... Agent: Hiscock & Barclay, LLP

20100291675 - Igm-mediated receptor clustering and cell modulation: Materials and methods for using multivalent molecules (e.g., antibodies) to modulate cellular function. A molecule can be targeted to a particular type of cell, either through direct binding to an epitope on the surface of the cell, or through a linker that recognizes both the multivalent molecule and a marker... Agent: Fish & Richardson P.C.

20100291672 - Reagent for introduction of protein or gene: (wherein in formula (I)-1: L is a single bond, —CONH—, or —S—S—; M1 is —(CH2)k— or —(CH2CH2O)k— (wherein k is an integer between 0 and 14); and m1 and m2 are each independently an integer between 11 and 21 (in this regard, when providing a reagent for introducing a gene... Agent: Birch Stewart Kolasch & Birch

20100291676 - Humanized anti-cd4 antibody with immunosuppressive properties: A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions.... Agent: Cermak Nakajima LLP

20100291677 - Reducer of immunosuppression by tumor cell and antitumor agent using the same: In order to provide a gene expression enhancer for enhancing expression of FoxP3 gene in a cell; a cell differentiation inducer for inducing differentiation of a cell into a regulatory T cell; an immunosuppressor for suppressing immunity and an agent for treating hyperimmune diseases based on the abovementioned actions; an... Agent: Clark & Elbing LLP

20100291678 - Regulatory t cells and their use in immunotherapy and suppression of autoimmune responses: Based upon a strong correlation between regulator T cells (Treg cells) and suppressing or preventing a cytotoxic T cell response, provided are methods for the production of ex vivo activated and culture-expanded isolated CD4+CD25+ suppressor Treg cells for the prevention or suppression of immune reactions in a host, particularly in... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100291679 - Composition for collecting and preserving placental stem cells and methods of using the composition: The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta. The invention provides a stem cell collection composition comprising an apoptosis inhibitor and, optionally, an enzyme such as a protease or mucolytic enzyme, vasodilator, necrosis inhibitor, oxygen-carrying perfluorocarbon, or an organ... Agent: Jones Day

20100291680 - Methods and compositions for inhibition of membrane fusion-associated events, including hiv transmission: The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID NO:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such... Agent: Jones Day

20100291681 - Methods and compositions for selecting sirna of improved functionality: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.... Agent: Kalow & Springut LLP

20100291683 - Modified antigen presenting cells and methods of use: The invention provides compositions comprising and methods of using antigen presenting cells into which has been introduced at least a first nucleotide sequence that encodes calnexin, wherein expression of calnexin in the antigen presenting cell increases the antigen presenting cell's ability to activate a T cell response.... Agent: Beusse Wolter Sanks Mora & Maire

20100291682 - System for transposing hyperactive recombinant derivatives of mos-1 transposon: The invention concerns a system for transposing a hyperactive recombinant derivative of Mos-1 transposon, comprising at least the two following partners: a) a Mos-1 pseudo-transposon in which an exogenous nucleotide sequence of interest replaces the nucleotide sequence encoding the original Mos-1 transposase; and b) a Mos-1 tranposase provided in trans... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20100291684 - Mutagenesis method using polyethylene glycol mediated introduction of mutagenic nucleobases into plant protoplasts: Method for targeted alteration of a duplex acceptor DNA sequence in a plant cell protoplast, comprising combining the duplex acceptor DNA sequence with a donor mutagenic nucleobase, wherein the duplex acceptor DNA sequence contains a first DNA sequence and a second DNA sequence which is the complement of the first... Agent: Foley And Lardner LLP Suite 500

  
11/11/2010 > patent applications in patent subcategories. recently filed with US Patent Office

20100285445 - Chimeric construct of mungbean yellow mosaic india virus (mymiv) and its uses thereof: A recombinant DNA construct, recombinant vectors and host cells comprising the dimers of DNA A and DNA B of Mungbean Yellow Mosaic India Virus (MYMIV) in a single Ti plasmid are provided herein.... Agent: Schwegman, Lundberg & Woessner, P.A.

20100285450 - Compositions and assays to detect influenza virus a and b nucleic acids: Methods for detecting influenza virus A and influenza virus B nucleic acids in biological samples by using in vitro amplification and detection are disclosed. Compositions that are target-specific nucleic acid sequences and kits comprising target-specific nucleic acid oligomers for amplifying in vitro influenza virus A or influenza virus B nucleic... Agent: Gen Probe Incorporated

20100285443 - Diagnostic methods for diseases caused by a hpv infection comprising determining the methylation status of the hpv genome: Methods and kits for diagnosing and/or monitoring the progression of or otherwise staging a disease caused by a human papillomavirus (HPV) infection in a test sample obtained from a subject comprise determining the methylation status of a HPV genome. The presence of hypermethylation of the HPV genome indicates a positive... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100285444 - Hbv precore protein capable of forming particles: There is provided a HBV precore protein having an ability of forming particles, and a means for determining it. A novel HBV precore protein that forms the virus (like) particles of HBV was identified. The present invention provides this novel HBV precore protein. Furthermore, there are provided core-like particles and... Agent: Foley And Lardner LLP Suite 500

20100285449 - Human g-protein chemokine receptor (ccr5) hdgnr10: Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20100285447 - Methods for antimicrobial resistance determination: The present invention relates to methods and systems for determining the antibiotic-resistance status of microorganisms. The invention further provides methods for determining the antibiotic-resistance status of microorganisms in situ within a single system.... Agent: Biomerieux Vitek Inc.

20100285446 - Methods for detecting metabolic states by laser ablation electrospray ionization mass spectrometry: According to certain embodiments, a method of mass spectrometry may generally comprise subjecting a sample comprising at least one indicator to laser ablation electrospray ionization mass spectrometry; determining a relative intensity of the indicator; and comparing the relative intensity of the indicator to a standard indicator intensity. Subjecting a sample... Agent: K&l Gates LLP

20100285448 - Retroviral nucleic material and nucleotide fragments, in particular associated with multiple sclerosis and/or rheumatoid arthritis, for diagnostic, prophylactic and therapeutic uses: An isolated polynucleotide having a nucleotide sequence selected from the group consisting of (a) SEQ ID NO: 21, (b) the full-length sequences encoding a polypeptide having a peptide sequence selected from the group consisting of SEQ ID NOs: 25 and 26, and (c) the full-length complementary sequences to the sequences... Agent: Oliff & Berridge, PLC

20100285467 - rapid and sensitive method for detection of biological targets: The present invention relates to a method of biological labeling that occurs via a free radical chain reaction. The labeling occurs due to deposition of a detectable reporter molecule from a media comprising a substance comprising at least two moieties of a peroxidase enzyme substrate (termed herein ‘cross-linker’) in a... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100285464 - A conserved region of the hiv-1 genome and uses thereof: The present invention discloses sequences having a structure and sequence homology to lox-P recombinase target site corresponding to a highly conserved region within the Long Terminal Repeats (LTR) of HIV and to the use thereof for the identification of recombinase enzymes useful in treating HIV-1.... Agent: Kevin D. Mccarthy Roach Brown Mccarthy & Gruber, P.C.

20100285484 - Apoptosis inducing positive control for expression modulation experiments: The invention pertains to a method for performing an expression modulating analysis or assay, wherein an apoptosis inducing expression modulating compound targeting a repetitive element present in the untranslated region, in particular the 3′ UTRs of protein coding gene transcripts is introduced into cells to induce apoptosis in the cells... Agent: Rankin, Hill & Clark LLP

20100285460 - Biological detection system and method: The present disclosure, according to some embodiments, relates to phage-based biological detection systems, compositions, and methods. In some embodiments, it relates to a detection system and method using phage binding and bacterial infection to detect the presence of a target molecule (e.g., a toxin). One detection system may include a... Agent: Baker Botts L.L.P. Patent Department

20100285453 - Cell culture article and methods thereof: A biosensor or cell culture article including: a substrate having a bio-compatible layer. The bio-compatible layer can be obtained from surface oxidation of a substrate coating comprising the reaction product of a suitable oxidizable polymer and modifier compound, such as a triamine, attached to the oxidizable polymer. Methods for making... Agent: Corning Incorporated

20100285468 - Detection and/or quantification of nucleic acids: The present invention provides compositions, methods, and kits for nucleic acids analyses. In particular, melting analyses are used to detect the presence or absence and to quantify nucleic acids.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100285451 - Detection of sub-cellular compartment localization of a molecule using a reduced affinity enzyme complementation reporter system: Methods and compositions for detecting the sub-cellular localization of a molecule are provided. Aspects of the invention include detecting translocation of a cell-surface receptor to a sub-cellular compartment, e.g., the endosome, using a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments... Agent: Peters Verny , L.L.P.

20100285474 - Diagnostic, predictive and prognostic testing for cancer: (b) assessing the level of a second biomarker selected from at least one of geminin, Aurora A, Plk1, Ki67 and H3S10ph in the biological sample from the subject, wherein the combination of the level of the first biomarker compared to a pre-determined value and the level of the second biomarker... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100285454 - Enclosed unit for rapid detection of a target nucleic acid amplification product: The invention relates to a method for rapid detection of a target nucleic acid amplification product while preventing cross-contamination between target nucleic acid amplification products and avoiding false positives, comprising the steps of: a) leaving the reaction tube unopened after the amplification reaction is finished, so as to prevent the... Agent: G Kenneth Smith

20100285466 - Esophageal cancer markers: The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression. Characteristic expression of the markers indicates the presence of cancer or the predisposition to cancer. A panel of eleven markers are particularly good at identifying... Agent: Banner & Witcoff, Ltd.

20100285487 - Fluorescent two-hybrid (f2h) assay for direct visualization of protein interactions in living cells: The present invention relates to an in vitro method for detecting protein-protein interactions comprising: (a) expressing in a eukaryotic cell a first fusion protein comprising (i) a (poly)peptide that, when expressed in a cell, accumulates at distinct sites in the nucleus of the cell or interacts with proteinaceous or non-proteinaceous... Agent: Dt Ward, PC

20100285475 - Fused genes: There is provided at least one isolated fused gene comprising at least one first gene and/or fragment thereof fused to at least one second gene and/or fragment thereof, wherein at least the first and/or the second gene, independently, is selected from the group consisting of: RCC2, CENPF, ARFGEF2, SULF2, MTAP,... Agent: Marshall, Gerstein & Borun LLP

20100285458 - Gene expression profiling for identification, monitoring, and treatment of lupus erythematosus: A method is provided in various embodiments for determining a profile data set for a subject with lupus or conditions related to lupus based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RWA corresponding... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100285457 - High-throughput diagnostic assay for the human virus causing severe acute respiratory syndrome (sars): The present invention relates to a high-throughput diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a high-throughput reverse transcription-PCR diagnostic test for SARS associated coronavirus (SARS-CoV). The present assay is a rapid, reliable assay which can be... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100285459 - Human diabetes susceptibility tnfrsf10a gene: The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the TNFRSF10A gene locus in a biological sample of said subject.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100285489 - Method for diagnosing renal diseases or predispositions: The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease... Agent: Leydig Voit & Mayer, Ltd

20100285477 - Method for predicting the response to a therapy: The invention concerns an in vitro method for selecting the therapy for a steroid resistant patient, wherein the method comprises isolating cells from a sample taken from said patient; cultivating said isolated cells in the presence of a steroid, an immunomodulatory oligonucleotide or a mixture thereof; determining an expression level... Agent: Dla Piper LLP (us)

20100285456 - Method for using dna repair capacity as a biomarker of breast cancer risk in women: Methods for the development of a breast cancer biomarker aimed at determining the risk of a woman to 1) develop breast cancer, 2) be free of breast cancer based on levels of overall DNA repair capacity as determined in blood lymphocytes. Examples on applicability of the methods to a human... Agent: Jaime Matta

20100285469 - Method of tumor screening: A method for tumor screening using urine of a mammal, the method includes obtaining a total urine nucleic acid (e.g., DNA) from a urine sample of a mammal, extracting a high molecular weight urine nucleic acid (above 1000 bp) by contacting the total urine nucleic acid with an adsorbent in... Agent: Woodcock Washburn LLP

20100285471 - Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas: Methods and compositions for the diagnosis, prognosis and/or treatment of esophageal adenocarcinoma and Barrett's esophagus associated adenocarcinoma are disclosed, along with more markers where a difference is indicative of esophageal adenocarcinoma and squamous cell carcinoma, and/or Barrett's esophagus associated adenocarcinomas or a predisposition thereto. The invention also provides methods and... Agent: Macmillan, Sobanski & Todd, LLC - Nih/osu

20100285462 - Methods and materials related to hair pigmentation and cancer: This document relates to methods and materials for determining whether or not a horse contains a Grey allele. For example, diagnostic methods such as nucleic acid-based detection methods and materials such as nucleic acid probes and primer pairs that can be used to determine whether or not a horse contains... Agent: Fish & Richardson P.C.

20100285481 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent: Husch Blackwell Sanders, LLP Husch Blackwell Sanders LLP Welsh & Katz

20100285482 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent: Husch Blackwell Sanders, LLP Husch Blackwell Sanders LLP Welsh & Katz

20100285476 - Methods of identifying histone deacetylase inhibitors useful for neurological disorders: A method of identifying a candidate compound for treatment of a neurological condition includes obtaining a test compound; assaying a first activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase 3 (HDAC3); assaying a second activity of the test compound to inhibit histone deacetylase activity... Agent: Fish & Richardson PC

20100285461 - Methods of producing and sequencing modified polynucleotides: The present invention encompasses methods for producing a modified polynucleotide sequence that comprises a (e.g., one or more) phosphorothiolate linkage, methods for determining a polynucleotide sequence comprising a (e.g., one or more) phosphorothiolate linkage, and methods for separating forward and reverse extension products that comprise a (e.g., one or more)... Agent: Life Technologies Corporation C/o Intellevate

20100285478 - Methods, compositions, and kits for detecting allelic variants: In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions... Agent: Life Technologies Corporation C/o Intellevate

20100285483 - Molecular diagnostic method and treatment in dementia with lewy bodies: The invention describes methods of molecular diagnosis of a concrete form of α-synucleinopathy, the dementia with Lewy bodies (DLB), associated to the levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) or the alteration of its ubiquityl-ligase activity. It also refers to the use of compounds that permit the modification of the... Agent: Traskbritt, P.C.

20100285452 - Molecular markers for the diagnosis and treatment of tumors: The invention relates to the diagnosis, prognosis, monitoring, and treatment of neoplastic diseases such as tumor diseases, especially tumor diseases of the endometrium and the metastases thereof.... Agent: Olson & Cepuritis, Ltd.

20100285465 - Molecular typing of neisseria strains by determining the presence of genes involved in lipooligosaccharide (los) biosynthesis: The present invention relates to a method of LOS molecular typing of a Neisseria strain by determining the presence of a functional gene and/or gene product of one or more genes involved in the biosynthesis of LOS.... Agent: Glaxosmithkline Global Patents

20100285470 - Monomethine dyes: Monomethine dyes that have no or minimal fluorescence in buffer or in the presence of single stranded DNA or RNA, but strongly fluoresce in the presence of double-stranded DNA. In one embodiment, the dye is useful in quantitative RT-PCR.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20100285486 - Non-invasive detection of bladder cancer by fluorescence in situ hybridization of aurora a: We disclose a method of detecting bladder cancer in a patient, comprising isolating bladder cells from the patient's urine; hybridizing the bladder cells with a labelled DNA probe, wherein the probe recognizes at least a portion of the aurora kinase A gene, to yield a sample of bladder cells hybridized... Agent: Williams, Morgan & Amerson

20100285455 - Prediction of schizophrenia risk using homozygous genetic markers: Provided are methods of identifying a genetic profile influencing the relative probability of a subject manifesting a phenotype that is at least partially heritable. Also provided are methods of determining the relative likelihood that a subject will manifest a phenotype that is at least partially heritable. Additionally, methods of determining... Agent: Amster, Rothstein & Ebenstein LLP

20100285485 - Primer, probe, dna chip containing the same and method for detecting human papillomavirus and detection kit thereof: The present invention discloses a primer, a probe, a DNA chip, and a test kit for diagnosis and genotyping of Human Papilloma Virus (HPV) as well as a method for testing HPV genotype. According to the present invention, it is possible to screen HPV genotypes with high sensitivity and specificity,... Agent: Merchant & Gould PC

20100285472 - Primers and probes for detection of high risk group geno-type human papillomavirus dna, a qualitative assay method of the same dna using them and a qualitative assay kit of the same dna: The present invention relates to a method for qualitative assay of high risk group Human Papillomavirus (HPV) DNA by PCR method using primers designed to detect the infection of 13 high risk group HPV which are closely associated with cervical cancer in a simple and precise way, and a kit... Agent: Martine Penilla & Gencarella, LLP

20100285463 - Selecting nucleic acid samples suitable for genotyping: The present invention relates to a method for selecting a DNA sample comprising genomic DNA suitable for genotyping, comprising the steps of: i) pre-genotyping said genomic DNA using a set of polymorphic markers; ii) determining out of said set of polymorphic markers the percentage of polymorphic markers for which said... Agent: Fulbright & Jaworski L.L.P.

20100285479 - Systems and methods for point-of-care amplification and detection of polynucleotides: Composition and methods for amplifying and detecting solution-state polynucleotide targets in a single device are described. In one aspect, a method for a coupled isothermal amplification and detection process utilizes a coated solid support, including a solid substrate, a cationic layer, and a plurality of target-specific probes attached to the... Agent: Brinks Hofer Gilson & Lione

20100285488 - T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection: The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure... Agent: Casimir Jones, S.c.

20100285480 - Tcl-1 gene and protein and related methods and compositions: The present invention relates to nucleotide sequences of TCL-1 genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The TCL-1 gene sequence is preferentially expressed early in T and B lymphocyte differentiation. The present invention further relates to the use... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100285473 - Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection: Disclosed herein are methods of amplifying a target nucleic acid in a helicase-dependent reaction. Also disclosed are methods of amplifying and detecting a target nucleic acid in a helicase-dependent reaction as well as modified detection labels to assist in the detection.... Agent: Ballard Spahr LLP

20100285494 - Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level: The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the... Agent: Fish & Richardson P.C.

20100285495 - Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level: The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the... Agent: Fish & Richardson P.C.

20100285490 - Detection apparatus: The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides... Agent: Life Technologies Corporation C/o Intellevate

20100285499 - Human p51 genes and gene products thereof: Novel human genes falling within the category of family genes relating to p53 gene which is known as a cell proliferation regulatory gene, and gene products thereof. A human p51 gene characterized by containing a base sequence encoding an amino acid sequence represented by SEQ ID NO:1; a human p51... Agent: Sughrue Mion, PLLC

20100285497 - Markers of endothelial cells and uses thereof: Use of a beta tubulin isotype that is differentially expressed between activated endothelial cells and quiescent endothelial cells for identifying an agent which inhibits or promotes angiogenesis and/or vascular function.... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20100285493 - Method for determining amino-terminal proanp in patients having a cardiac disease or being suspected of developing or having a cardiac disease: The present invention relates to an in vitro method for medical diagnosis, prognosis and therapy follow-up for patients having a cardiac disease or being suspected of developing or having a cardiac disease comprising the steps of: providing a sample of a patient having a cardiac disease or being suspected of... Agent: Millen, White, Zelano & Branigan, P.C.

20100285496 - Methods and devices for the detection of biofilm: The present invention provides methods and kits for biofilm detection.... Agent: Nevrivy Patent Law Group P.l.l.c

20100285498 - Methods for detecting pre-diabetes and diabetes using differential protein glycosylation: Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include... Agent: Schwabe Williamson & Wyatt Pacwest Center, Suite 1900

20100285501 - Methods for diagnosing endometriosis: Provided herein is a method for diagnosing and monitoring endometriosis in a subject by measuring levels of the β-subunit of fibrinogen.... Agent: Polsinelli Shughart PC

20100285500 - Neurofurans-indices of oxidant stress: The invention is drawn to a new class of isoeicosanoids that have been identified as products of the oxidation of docosahexaenoic acid (DHA). The invention provides compositions and methods related to the new class of molecules.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100285491 - Use of igfbp-7 in the assessment of heart failure: The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker IGFBP-7, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing... Agent: Roche Diagnostics Operations Inc.

20100285492 - Use of slim-1 in the assessment of heart failure: The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker SLIM-1, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing... Agent: Roche Diagnostics Operations Inc.

20100285504 - Monoclonal antibody which binds met in formalin-fixed and paraffin-embedded tissues and related methods: In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4.... Agent: Price Heneveld Cooper Dewitt & Litton, LLP

20100285505 - Device and method for detecting a substance by means of particle plasmon resonance (ppr) or particle-mediated fluorescence based on cell surface polarizations: The invention relates to devices and methods for detecting a substance by cell surface polarizations and the detection thereof by means of PPR or particle-mediated fluorescence. The device for detecting a substance by cell surface polarization according to the invention has cells, wherein a gene the expression of which leads... Agent: Gudrun E. Huckett Draudt

20100285506 - Immunodetection assay for mycobacterium tuberculosis complex: The present invention provides a method for specifically detecting a Mycobacterium tuberculosis complex-specific secretory protein MPT64 antigen in a biological sample, whereby diagnosis of infection with Mycobacterium tuberculosis is carried out rapidly and safely with higher accuracy than before. An antibody that recognizes an epitope for MPB64 located in any... Agent: Fitch, Even, Tabin & Flannery

20100285502 - Novel aromatic prenyltransferases, nucleic acids encoding same and uses therefor: In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation of a C—C bond between a prenyl group and a compound containing an aromatic nucleus, and also... Agent: Foley & Lardner LLP

20100285503 - Fret-based binding assay: The present invention provides for an assay that identifies kinase inhibitors by employing fluorescence resonance energy transfer in a competition binding approach.... Agent: Roche Palo Alto LLC Patent Law Dept. M/s A2-250

20100285510 - Marker for inflammatory conditions: Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.... Agent: Fish & Richardson P.C.

20100285509 - Melanoma-associated endogenous retrovirus (merv) derived peptide sequences and their therapeutic/diagnostic use: The present invention provides antigenic polypeptides derived from the melanoma-associated endogenous retrovirus (MERV). These antigens are useful compounds for the detection of cancerous cells and melanoma-diagnosis as well as melanoma-prognosis. Furthermore these antigenic polypeptides of the present invention form the basis for anti-cancer vaccines.... Agent: Fulbright & Jaworski L.L.P.

20100285507 - Plasma kallikrein fragments as diagnostic biomarkers for lung cancers: Disclosed herein are diagnostic markers for lung cancer, isolated from serum glycoproteins. The disclosed diagnostic markers for lung cancer are specifically expressed only in the sera of lung cancer patients at high levels, and thus will be very useful for diagnosing lung cancer and estimating disease progression and treatment.... Agent: Ladas & Parry LLP

20100285508 - Use of the protein em6 as a performance marker for germination of seed lots and applications thereof: The invention relates to the determination of the level, maintenance and/or performance of germination of a seed lot, by quantification of the protein EM6, belonging to the group of Late Embryogenesis Abundant (LEA) proteins. The present invention further relates to antibodies permitting the quantification of the protein EM6.... Agent: Morgan Lewis & Bockius LLP

20100285511 - Transformed cell with enhanced sensitivity to antifungal compound and use thereof: The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at least one hybrid-sensor kinase, a method of assaying the... Agent: Sughrue Mion, PLLC

20100285512 - Functionalized biochips for spr-ms coupling: The invention relates to a method for coupling in-line the analysis of molecular interactions by surface plasmon resonance (SPR) with a structural identification by mass spectrometry using the same functionalized support for both types of analysis.... Agent: Nixon & Vanderhye, PC

20100285513 - Methods of analyzing peptide mixtures: The present invention provides for a method of characterizing and classifying a sample of peptide or polypeptide mixtures or a biomolecule comprising a polypeptide component by using mass spectrometry and statistic methods for analyzing the mass spectrometry results.... Agent: Cohen, Pontani, Lieberman & Pavane LLP

20100285514 - Electrochemical biosensor: Networks of single-walled carbon nanotubes (SWCNTs) decorated with Au-coated Pd (Au/Pd) nanocubes are employed as electrochemical biosensors that exhibit excellent sensitivity (2.6 mA mM−1 cm−2) and a low estimated detection limit (2.3 nM) at a signal-to-noise ratio of 3 (S/N=3) in the amperometric sensing of hydrogen peroxide. Biofunctionalization of the... Agent: Bingham Mchale LLP

20100285516 - Calcium flux as a pharmacoefficacy biomarker for inhibitors of histone deacetylase: Described herein are methods for using calcium flux as a biomarker to select and predict patients likely to respond to an apoptotic agent as therapy. Further described herein is a method of using calcium flux as a clinical biomarker to determine whether a tumor is sensitive to an HDAC inhibitor.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100285515 - Fluorescent probe: [wherein R1 and R2 represent a C1-6 alkyl group; R3, R4 and R5 represent hydrogen atom, a C1-6 alkyl group, or an aryl group; Y1 and Y2 represent —O—, —S—, —Se—, —CH═CH—, —C(R6)(R7)—, or —N(R8)— (wherein R6, R7 and R8 represent hydrogen atom or a C1-6 alkyl group); A represents... Agent: Greenblum & Bernstein, P.L.C

20100285518 - Photoacoustic detection of analytes in solid tissue and detection system: A preferred system for detecting an analyte in solid tissue, such as an intact lymph node, in vitro includes a laser arranged to generate a pulsed laser beam into solid tissue, which can be a fully intact lymph node. An acoustic sensor, and preferably at least three acoustic sensors are... Agent: Greer, Burns & Crain

20100285519 - Quinolinone-carboxamide compounds as 5-ht4 receptor agonists: The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds of Formula (I). The invention also provides pharmaceutical compositions comprising such compounds, the use such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds. Wherein; R1 is hydrogen, halo, hydroxy, C1-4 alkyl,... Agent: Theravance, Inc.

20100285517 - Trimethylamine compounds as risk predictors of cardiovascular disease: Methods of characterizing a test subject's risk of having or developing cardiovascular disease are provided. The methods include using an analytic device to determine levels of choline-related trimethylamine-containing compounds such as trimethylamine N-oxide, choline, or betaine in a biological sample obtained from the subject and comparing the levels of the... Agent: Calfee Halter & Griswold, LLP

20100285520 - Sample preparation for environmental sampling: A system and method for preparing samples to test an environmental surface for an analyte of interest. The system can include a deformable self-supporting receptacle comprising a reservoir, and a loaded substrate positioned in the reservoir of the deformable self-supporting receptacle. The loaded substrate can include a substrate and a... Agent: 3m Innovative Properties Company

20100285521 - Adipose tissue collection and pre-processing devices for use in liposuction procedure: Devices and methods are described for pre-processing tissue samples containing cells of interest for various therapeutic procedures. Fibrous material may be extracted from the tissue sample through a shredding and separating device, resulting in a non-fibrous sample containing the cells of interest, which may then be washed and centrifuged to... Agent: Nixon Peabody LLP

20100285522 - Versatile multichannel capillary biosensor system: The multichannel capillary biosensor system includes a selecting valve system for selection of the sample or a reagent. The selecting valve system is connected to a second valve system accommodating a sensing channel and a first bypass channel. The second valve system is connected to a directing valve system having... Agent: J. Charles Dougherty Wright, Lindsey & Jennings LLP

20100285523 - System and method for analyzing fluids: A spectrometric sensor for measuring a spectra value of a flowing fluid. The spectrometric sensor comprises a light source for emitting a first light flux toward a sample of the flowing fluid, a light detector for measuring a first intensity of a reflection of the first light flux from the... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100285524 - Novel microorganism and method for producing carotenoid using the same: [Solving Means] A carotenoid producing bacterium belonging to the genus Paracoccus is provided which selectively produces canthaxanthin so that the amount thereof is not less than 90 percent by weight of the total amount of produced carotenoids including β-carotene, β-cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3′-hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin, and astaxanthin. In... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100285525 - Method: A method of producing one or more of a carbohydrate ester, a protein ester, a protein subunit ester or a hydroxyl acid ester, which method comprises admixing an acyl donor, an acyl acceptor and water to produce a high water environment comprising 5-98% water, wherein said acyl donor is a... Agent: Frommer Lawrence & Haug

20100285526 - Compositions and methods for fusion protein separation: The present invention relates to compositions and methods for fusion protein separation utilizing a peptide linker comprising a novel thrombin cleavage site.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100285529 - Feline granulocyte macrophage colony stimulating factor proteins: The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins; to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD 154, canine interleukin-5,... Agent: Sheridan Ross PC

20100285528 - Method, vector and system for expressing polypeptides: Disclosed herein are methods and systems for expressing a polypeptide in a Rhodospirillum species. The methods include introducing an expression vector having a nucleic acid sequence encoding the polypeptide operably linked to a puc promoter into the Rhodospirillum bacterium and growing the Rhodospirillum bacterium under conditions that allow expression of... Agent: Michael Best & Friedrich LLP

20100285527 - Novel polypeptide, cdna encoding the same, and use thereof: Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or... Agent: Sughrue-265550

20100285530 - E.coli host cells with modified phos/psts periplasmic phosphate-binding proteins, and method of manufacturing recombinant fabs: The present invention provides an E. coli host cell expressing a recombinant antibody characterized in that the E. coli host cell has been genetically modified in order to change at least one physical property of one or more E. coli proteins which in the wild type co-purify with said recombinant... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100285531 - Therapeutic and diagnostic methods and compositions targeting 4ig-b7-h3 and its counterpart nk cell receptor: The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100285532 - Production of heterologous proteins or peptides: A method of producing a flagellin-based chimeric protein includes culturing a B. halodurans BhFD05 (Δhag, ΔfliD, ΔwprA, Δalp, Δapr, Δvpr, Δasp) strain deposited under Accession Number 41533 at the NCIMB. The strain is caused to express and secrete high levels of a flagellin-based chimeric protein into an extracellular growth medium.... Agent: Mcdermott, Will & Emery

20100285533 - Culture media additive and process for using it: The present invention relates to an improved cell culture additive with a content of polyamines and iron, media containing it and processes for using it for an improved cell growth, cell viability or cellular productivity.... Agent: Ostrolenk Faber Gerb & Soffen

20100285534 - Combined thermochemical pretreatment and refining of lignocellulosic biomass: One aspect of the present invention relates to a method of processing lignocellulosic material, comprising initial steam pretreatment to give pretreated lignocellulosic material with an average particle size, followed by refining to give refined lignocellulosic material with an average particle size, wherein the average particle of the pretreated lignocellulosic material... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20100285536 - Method and apparatus for amplification of nucleic acid sequences by using thermal convection: The present invention provides a nucleic acid sequence amplification method and apparatuses thereof that are simple in the design and easy to miniaturize and integrate into complex apparatuses, with capability of using DNA polymerases that are not thermostable. In the present invention, a plurality of heat sources are combined to... Agent: Jhk Law

20100285538 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent: Husch Blackwell Sanders, LLP Husch Blackwell Sanders LLP Welsh & Katz

20100285535 - Pcr hot start by magnesium sequestration: The present invention is directed to a synthetic peptide having a length of not more than 30 amino acids comprising a divalent cation binding site. Such a peptide according to the present invention is part of a composition for nucleic acid amplification and provides for a so-called hot start effect.... Agent: Dinsmore & Shohl, LLP Fifth Third Center

20100285537 - Selective tagging of short nucleic acid fragments and selective protection of target sequences from degradation: Methods are provided for selective tagging of short nucleic acids comprising a short target nucleotide sequence over longer nucleic acids comprising the same target nucleotide sequence. The methods can involve performing one or two cycles of amplification of a sample comprising long nucleic acids and short nucleic acids, each comprising... Agent: Weaver Austin Villeneuve & Sampson LLP

20100285539 - Process for manufacturing tagatose using soy oligosaccharide: The present invention relates to a method for producing tagatose using soy oligosaccharide or soluble sugar solution containing the same, more precisely, a method for producing tagatose comprising the following steps; hydrolyzing soy oligosaccharide by using α-galactosidase selectively; producing tagatose continuously by enzymatic isomerization of galactose obtained from the hydrolysate;... Agent: Swanson & Bratschun, L.L.C.

20100285540 - Process for the preparation of (r)-beta-arylalanines by coupled racemase/aminomutase catalysis: A process for producing (R)-β-arylalanines is described. The process converts (S)-α-arylalanine to (R)-β-arylalanine using phenylalanine aminomutase and amino acid racemase. The (R)-β-arylalanine product can be used to form pharmaceutically useful drugs. Also disclosed are DNA sequences encloding phenylalanine aminomutase and amino acid racemase enzymes, sequences for PCR primers of the... Agent: Butzel Long

20100285541 - Transaminase biocatalysts: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.... Agent: Dechert, LLP

20100285542 - Catalyzed preparation of (meth)acrylates of n-hydroxyalkylated amides: The claimed invention relates to a process for preparing (meth)acrylates of N-hydroxyalkylated amides, in which open-chain N-hydroxyalkylated amides are esterified with (meth)acrylic acid or transesterified with at least one (meth)acrylic ester in the presence of at least one heterogeneous catalyst selected from the group consisting of an inorganic salt and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100285543 - Novel endophytic fungi and methods of use: This invention provides a novel endophytic fungus, Muscodor, that produces a mixture of volatile antibiotics with activity on specific plant pathogens, bacteria, nematodes and insects. Also provided is a method for treating or protecting plants, soil and seeds from microbial infections comprising applying an effective amount of a volatile antibiotic... Agent: Agraquest, Inc.

20100285544 - Novel aminotransferase, gene encoding the same, and method of using them: The invention relates to a novel aminotransferase, DNA encoding the enzyme, a recombinant vector into which the DNA has been introduced, and a transformant into which the vector has been introduced. Further, the invention also relates to a method for producing an optically active amino compound utilizing the enzyme or... Agent: Birch Stewart Kolasch & Birch

20100285545 - Biosynthetic routes to long-chain alpha,omega-hydroxyacids, diacids and their conversion to oligomers and polymers: A substantially pure Candida host cell for the production of a α-carboxyl-ω-hydroxy fatty acid having a carbon chain length in the range from C6 to C22, a α,ω-dicarboxylic fatty acid having a carbon chain length in the range from C6 to C22, or mixtures thereof, is provided. The Candida host... Agent: Jones Day

20100285546 - Genetically modified microorganisms for producing itaconic acid with high yields: Genetically modified microorganisms that produce itaconic acid at high yields and uses thereof.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100285547 - New micro-organisms for the production of 1,2-propanediol obtained by a combination of evolution and rational design: The present invention also concerns the evolved strain such as obtained, that may be furthermore genetically modified in order to optimize the conversion of a carbon source into 1,2-propanediol without by-products and with the best possible yield.... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100285548 - Process and apparatus for the microbial production of a specific product and methane: The process according to the invention for the microbial production of a specific product and methane comprises the following steps: a) the production in a bioreactor (2, 10) of a specific product from a specific substrate using a specific organism, the producer, wherein during the production of this product metabolites... Agent: Rankin, Hill & Clark LLP

20100285550 - Delignification of lignocellulose-containing material: The invention relates to processes of delignifying lignocellulose-containing material, wherein the lignocellulose-containing material is treated with a delignification catalyst and a lignin solubilizing agent.... Agent: Novozymes North America, Inc.

20100285549 - Recombinant microorganism having butanol production capacity and butanol production method: This invention relates to a recombinant microorganism having improved butanol production capacity and butanol production with the use of such recombinant microorganism with good efficiency. In this invention, the acetoacetyl-CoA synthase gene encoding an enzyme capable of synthesizing acetoacetyl-CoA from malonyl-CoA and acetyl-CoA and a group of genes involved in... Agent: Sughrue Mion, PLLC

20100285551 - Method of stimulating ethanol production and growth of aquatic plants: A method of stimulating ethanol production and growth of aquatic plants includes the steps of placing aquatic plants in a cell containing water and creating an oxygenated condition within the cell to initiate an aerobic process. The aquatic plants create and store carbohydrates during the aerobic process. The cell is... Agent: Sean Kaufhold

20100285552 - Methods for fermentation of xylose and hexose sugars: Methods and systems for the isomerization and/or fermentation of xylose and hexose sugars are disclosed.... Agent: Macmillan Sobanski & Todd, LLC

20100285553 - Process for pretreating a lignocellulosic material with a view to producing bioethanol, and bioethanol production process: t

20100285555 - Distributed biofuel manufacturing system (dbms): The Distributed Biofuel Manufacturing System (DBMS) integrates three critical innovations which may advance the state of the art for biofuels manufacturing to a distributed production and local distribution model. This model yields a sustainable and commercially viable means of production for biofuels. Essential to this new model is a Portable... Agent: Raj Abhyanker, P.C.

20100285554 - Method of stimulating ethanol production and growth of aquatic plants: A method of stimulating ethanol production and growth of aquatic plants includes the steps of placing aquatic plants in a cell containing water and creating an anoxic condition within the pool to initiate an anaerobic process by the aquatic plants. The aquatic plants increase in size and release ethanol by... Agent: Sean Kaufhold

20100285556 - Biogas plant and process for the production of biogas from ligneous renewable resources: The present invention relates to a biogas plant and to a process for the production of biogas from ligneous renewable resources, in particular straw. Means are provided for pre-treating the ligneous renewable resource in order to bring about chemical, thermal and/or mechanical digestion of said resource before it is introduced... Agent: Foley And Lardner LLP Suite 500

20100285557 - Efficient astaxanthin production strains derived from haematococcus pluvialis: The present invention pertains to a method for the efficient production of carotenoids. In particular, the present invention is directed to a method for producing carotenoid and carotenoid-containing cells, especially astaxanthin and astaxanthin-containing cells, by generating mutant microorganisms belonging to the photoautotrophic algae of the Class Chlorophyceae and culturing same.... Agent: Fox Rothschild LLP

20100285558 - Apparatus and method for high-throughput micro-cell culture with mechanical stimulation: An apparatus for high-throughput micro-cell culture with mechanical stimulation includes a cell culture vessel and a fluid pressure supply unit. The cell culture vessel has the membrane, a culture medium chamber, and a pressure chamber. The fluid pressure supply unit is connected fluidly to the pressure chamber, and has a... Agent: Whyte Hirschboeck Dudek S C Intellectual Property Department

20100285559 - Radiation-resistant mutants of a halophilic archaeon and uses thereof: The present invention relates to variants of the model halophile Halobacterium sp. NRC-1 that have been exposed to cycles of irradiation with high doses of 18-20 MeV electrons. These novel isolated halobacterium exhibit increased resistance to radiation and may be used for bioremediation of toxic and highly radioactive waste sites... Agent: Moore & Van Allen PLLC

20100285560 - Reticulocyte mimetics and method of preparation of the same: In one aspect of the present disclosure there is provided a method for preparing reticulocyte mimetics. In another aspect of the present disclosure there are provided reticulocyte mimetics obtained using the method. In yet another aspect of the present disclosure there is provided a whole blood reference control including the... Agent: Mindray C/o Stoel Rives LLP

20100285561 - Immobilisation of biological molecules: A method of immobilising a biological molecule on a substrate comprises: (i) covalently attaching a substantially three-dimensional polysilane polymer to a substrate; and (ii) attaching a biological molecule onto and/or within the polymer. The method may additionally comprise the steps of coating the substrate (or the chemically protective layer) with... Agent: Knobbe Martens Olson & Bear LLP

20100285562 - Isocyclomaltooligosaccharide(s), isocyclomaltooligosaccharide-forming enzyme, their preparation and uses: m

20100285563 - Non-ribosomal peptide synthetases: Novel tailor-made artificial non-ribosomal peptide synthetases (NRPSs) for non-ribosomal synthesis and/or modification of peptides of a predetermined length and composition and/or for modification of individual amino acids are described. The fusion of building units of said peptide synthetases in particular linker regions makes it possible to specifically prepare by means... Agent: K&l Gates LLP

20100285564 - Anticalins: The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus... Agent: Foley And Lardner LLP Suite 500

20100285565 - Escherichia coli expressing the cytochrome p-450 gene and a method for microbial conversion using them: Disclosed is a means for improving the poor conversion efficiency in a bioconversion system using an Escherichia coli cell having a bacterium-originated cytochrome P-450 gene integrated therein. A recombinant Escherichia coli cell is produced by introducing aciB and aciC which encode a gene for the electron transport system originated from... Agent: Jacobson Holman PLLC

20100285566 - Glucose dehydrogenase and method for producing the dehydrogenase: A novel glucose dehydrogenase, which is an enzyme that has high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior, thermal stability is obtained by culturing a microorganism belonging to the genus Burkhorderia and having... Agent: Knobbe Martens Olson & Bear LLP

20100285567 - Tat signal peptides for producing proteins in prokaryotes: This invention provides polynucleotides encoding TAT fusion proteins, and methods for producing proteins of interest in a host cell. In particular, the present invention relates to polynucleotides, vectors, polypeptides and methods for expressing organophosphate-degrading enzymes e.g. organophosphorus hydrolase (OPH) in host cell, such as a Streptomyces species host cell.... Agent: Danisco US Inc. Attention: Legal Department

20100285568 - Recombinant factor x with no glycosylation and method for preparing the same: A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100285569 - Pectate lyases with increased thermostability and/or enzymatic activity: Using site-directed mutagenesis to mutate the Xanthomonas campestris pectate lyase gene, variants of Xanthomonas campestris pectate lyase with improved thermostability and/or enzymatic activity have been expressed in Escherichia coli, and then isolated and purified. The mutant Xanthomonas campestris pectate lyases are more effective than the wild-type enzyme, also expressed in... Agent: National Research Council Of Canada

20100285570 - Fluoride processing method: The invention relates to methods for processing [18F]-fluoride target water using a solid-support bound Cryptand of formula (I) and to apparatus for performing such methods. The resultant [18F]-fluoride is useful for preparation of radiopharmaceuticals by nucleophilic fluorination, specifically for use in Positron Emission Tomography (PET).... Agent: Ge Healthcare, Inc.

20100285571 - Systems and methods for auto-calibration of resistive temperature sensors: The invention relates to systems and methods for calibrating and using resistance temperature detectors. In one embodiment, the system includes a calibration circuit comprising a resistance temperature detector in a bridge circuit with at least one potentiometer, and a programmable gain amplifier coupled to the bridge circuit. Embodiments of the... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100285572 - Inhibition assay method and device for detection of antibiotics: An aspect of the disclosure is a method and device for the detection of antibiotics in a sample. Embodiments include a microbial culture with growth indicators and sensitivity adjustment reagents. Adjustment reagents include a variety of antibiotic binders that can be added to microbial culture to reduce sensitivity to certain... Agent: Charm Sciences, Inc.

20100285573 - Apparatus for processing a sample in a liquid droplet and method of using the same: The invention provides an apparatus and a method of processing a biological and/or chemical sample in a liquid droplet. The apparatus comprises a processing compartment, which is defined by a reservoir and an immobilisation member. The processing compartment is further adapted to accommodate a medium, which is immiscible with the... Agent: Sunstein Kann Murphy & Timbers LLP

20100285574 - Biomass hydrothermal decomposition apparatus and method: A biomass hydrothermal decomposition apparatus includes, a biomass feeder (31) that feeds biomass material (11) under normal pressure to under increased pressure, a hydrothermal decomposition device (41A) that allows the fed biomass material (11) to be gradually moved inside a gradient device main body (42) from a lower end thereof... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100285575 - Bioreactor: The invention relates to a bioreactor which comprises a closed housing with a housing wall and at least one chamber which is connected to the housing wall. The at least one chamber comprises a chamber inlet and outlet for respectively supplying and discharging material to and from the at least... Agent: Sughrue Mion, PLLC

20100285576 - Method to produce synthesis gas or liquid fuels from commingled algae and coal feedstock using a steam-hydrogasification reactor and a steam methane reformer with co2 utilization through an algae farm: This invention involves the conversion of coal-algae or resid-algae commingled slurry feedstock into a high methane content product gas using a steam hydrogasification process. This gas is then reformed into synthesis gas (H2 and CO). Excess H2 from the synthesis gas is separated and recycled back to the gasifier. The... Agent: Berliner & Associates

20100285577 - Isolation, characterization and propagation of germline stem cells: Methods are provided for the isolation, characterization and propogation of germline cells stem cells from fetal and adult mammals. Additionally, isolated populations of germline cells having different phenotypes are disclosed wherein the subpopulations are capable of forming long-term cultures of multipotent or pluripotent cells or are capable of differentiating into... Agent: K&l Gates LLP

20100285578 - Nucleic acid purification: The inventive self-contained apparatus for isolating nucleic acid, cell lysates and cell suspensions from unprocessed samples apparatus, to be used with an instrument, comprises at least one input, and: (i) a macrofluidic component, comprising a chamber for receiving said unprocessed sample from a collection device and at least one filled... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100285579 - Preantral follicle derived embryonic stem cells: The present invention relates to a method for producing a preantral follicle-derived embryonic stem cell and a preantral follicle-derived embryonic stem cell. The present method comprises the steps of (a) obtaining a preantral follicle from mammalian ovaries; (b) growing the preantral follicle in vitro; (c) maturing an oocyte in vitro... Agent: The Nath Law Group

20100285580 - Cardiac conduction system (ccs) progenitor cells and uses thereof: The present invention provides isolated stem cells and progenitor cells, including HCN4-expressing CCS progenitor cells, HCN4- and Islet 1-expressing sinoatrial node cells or progenitor cells thereof, and Islet 1-expressing cardiovascular stem cells that do not express HCN4. The invention further provides differentiated cell types derived from the CCS progenitor cells... Agent: Dla Piper LLP (us)

20100285581 - Solid phase cell isolation and/or enrichment method: The present invention concerns a solid phase method for isolating and/or enriching predetermined cells from a sample. Such methods are used e.g. to isolate and enrich predetermined cells like fetal cells from a sample of maternal peripheral blood, tumor cells from a sample of body fluid or stem cells from... Agent: Fulbright & Jaworski L.L.P.

20100285583 - Compounds and methods for inhibiting platelet aggregation: The present invention relates to compounds and methods for inhibiting platelet aggregation. In an embodiment, the compound of the present invention contains the sulfatide binding region of the N-terminal phosphotyrosine binding domain (N-PTB) of Disabled-2 (Dab2).... Agent: Blank Rome LLP

20100285582 - Various human dental stem cells having a mineralization ability and the method for culturing them: The present invention relates to various human dental stem cells having a mineralization ability and a method for culturing the same, more precisely postnatal stem cells having a mineralization ability, which are separated from human dental tissues such as dental pulp (DPSCs), periodontal ligament (PDLSCs), periapical follicle (PAFSCs) and mandibular... Agent: Lucas & Mercanti, LLP

20100285584 - Engineered cellular pathways for programmed autoregulation of differentiation: The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into... Agent: Medlen & Carroll, LLP

20100285585 - Method for extracellular matrix mediated differentiation and proliferation of stem cells: There is provided a method of culturing a stem cell on extracellular matrix extracted from support cells and in a stem cell culture medium comprising medium conditioned by the support cells... Agent: Klarquist Sparkman, LLP

20100285586 - Method of producing a population of cells: A method is provided for producing an in vitro or ex vivo method of producing a population of lineage committed haematopoietic progenitor, or mature haematopoietic cells, other than cells of the neutrophil lineage, which method comprises the steps of: (a) providing a population of cells comprising haematopoietic progenitor cells; and... Agent: Edwards Angell Palmer & Dodge LLP

20100285587 - Tissue graft: A method of preparing a tissue graft material is disclosed. The disclosure also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue.... Agent: Sutherland Asbill & Brennan LLP

20100285588 - Apparatus and methods for cell isolation: A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and... Agent: Fish & Richardson P.C.

20100285589 - Generation of pluripotent cells from fibroblasts: Provided are methods and compositions useful for producing and propagating stem cells from fibroblasts.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100285590 - Homologous recombination in multipotent adult progenitor cells: The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC... Agent: Thompson Hine L.L.P. Intellectual Property Group

20100285591 - Cyclin d polynucleotides, polypeptides and uses thereof: The invention provides isolated polynucleotides, specifically Cyclin D polynucleotides, and their encoded proteins that are involved in cell cycle regulation. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention provides methods and compositions relating to altering cell cycle protein content and/or composition... Agent: Pioneer Hi-bred International, Inc.

20100285592 - Single expression vector for generation of a virus with a segmented genome: The present invention encompasses an expression vector that is capable of generating a virus from a segmented genome. In particular, a single expression vector may be utilized to produce influenza virus in cultured cells. The expression vector can be delivered in a purified DNA form or by a suitably designed... Agent: Polsinelli Shughart PC

  
11/04/2010 > patent applications in patent subcategories. recently filed with US Patent Office

20100279268 - Method for creating perfusable microvessel systems: A method for creating networks of perfusable microvessels in vitro. Cells including cell types capable of sprouting are seeded 1300 into a channel in a matrix at to activate competency 1304 of the cells for sprouting as microvessels based on the seeding density. The matrix channel is perfused with medium... Agent: George A Leone, Sr Citadel Patent Law

20100279269 - Characterization of n-glycan mixtures by nuclear magnetic resonance: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such... Agent: Choate, Hall & Stewart LLP

20100279270 - Process for production and quantitation of high yield of biobutanol: The present invention provides a process for production of high yields of butanol by Clostridium acetobutylicum ATCC 10132. The process can be completed in a shorter span of time, using batch process through manipulation of various process parameters. The process can also be used for biomass based production of butanol.... Agent: Foley And Lardner LLP Suite 500

20100279275 - Human gastrointestinal stem cell-derived primary intestinal epithelial cell system and methods of use thereof: The present invention relates to an intestinal primary epithelial cell system for detecting gastrointestinal segment-specific activation or suppression of a Toll-like receptor (TLR) by a target agent. The cell system includes an isolated human intestinal primary epithelial cell (HIPEC) line that expresses at least one TLR, where the HIPEC line... Agent: Heslin Rothenberg Farley & Mesiti PC

20100279274 - Method of pooling and/or concentrating biological specimens for analysis: The present invention provides methods for concentrating and pooling liquid suspensions of biological specimens containing analytes of interest in a dry state. The dried biological specimens containing analytes of interest are reconstituted and released from the matrix for subsequent analysis in concentrated form.... Agent: Sutherland Asbill & Brennan LLP

20100279276 - Methods for determining the presence of sars coronavirus in a sample: Methods for determining the presence of SARS-CoV in a test sample that include targeting the SARS-CoV 5′ leader sequence or the SARS-CoV 3′ terminal sequence.... Agent: Gen Probe Incorporated

20100279277 - Methods of evaluating a test agent in a diseased cell model: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100279272 - Multiplexed analysis methods using sers-active nanoparticles: Methods are described for performing a multiplexed analysis of a level of target analyte in a sample, employing an identifier and a labeling reagent. Either or both of the identifier and the labeling reagent comprises a SERS-active nanoparticle associated with a SERS-active reporter with a uniquely identifiable spectroscopic signature. Interrogation... Agent: Patent Docket Department Armstrong Teasdale LLP

20100279273 - Nucleic acid sequences for the amplification and detection of respiratory viruses: The present invention relates to methods of detection, as well as assays, reagents and kits for the specific detection of 15 clinically important respiratory viruses including influenza A and B viruses, human respiratory syncytial viruses, human metapneumoviruses, human enteroviruses, all serotypes of rhinoviruses, 7 serotypes of adenoviruses, parainfluenza viruses types... Agent: Choate, Hall & Stewart LLP

20100279271 - Sample collection apparatus: A sample collection apparatus which measures biological samples and can be used to provide the early detection of respiratory diseases, for example tuberculosis induced by the pathogen mycobacterium tuberculosis. The sample collection apparatus has a sample collection unit and a corresponding complementary reader unit. The collection unit collects a sample... Agent: Thomas M. Galgano

20100279290 - microbiological detection method: A method for detecting the presence of a hydrocarbon deposit (2) in a geographical location (1). The method comprises the steps of: detecting the presence, at the location, of a target polynucleotide encoding a protein capable of metabolising a hydrocarbon, wherein the presence of the target polynucleotide is indicative of... Agent: Roberts Mlotkowski Safran & Cole, P.C. Intellectual Property Department

20100279279 - Compositions and methods for analysis of target analytes: Compositions and methods are provided for analyzing a sample for the presence or absence of one or more target analytes. Microparticles bound to an analyte of interest are incubated in a solution containing a primary antibody directed towards the analyte. In direct assays of this invention, the microparticle-bound analyte competes... Agent: Borson Law Group, PC

20100279287 - Compositions and methods useful for site-directed recombination in plants: This invention relates generally to useful compositions and methods related to plant site-directed recombination. In particular, the invention relates to novel nucleic acid sequences unique to a portion of the sorghum NBS-LRR region, as well as vectors, seeds, plant parts and plants comprising these sequences. Methods to investigate recombination co-factors,... Agent: Davis Wright Tremaine LLP - San Francisco

20100279305 - Compositions, methods, and kits for detecting ribonucleic acid: Compositions, methods, and kits for detecting one or more species of RNA molecules are disclosed. In one embodiment, a first adaptor and a second adaptor are ligated to the RNA molecule using a polypeptide comprising double-strand specific RNA ligase activity, without an intervening purification step. The ligated product is reverse... Agent: Life Technologies Corporation C/o Intellevate

20100279299 - Devices and methods for heating biological samples: This invention provides a systems and methods for regulating temperature and heat transfer in applications in which it is desirable to maintain temperature uniformity such as thermal cycling applications. A heat block is used to rapidly transfer heat to or from a set of one or more reaction vessels.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100279296 - Enhanced fc receptor-mediated tumor necrosis factor superfamily mrna expression in peripheral blood leukocytes in patients with rheumatoid arthritis: A method for predicting patient responsiveness to rheumatoid arthritis treatments involving altering expression of tumor necrosis factor superfamily (“TNFSF”)-2, TNFSF-8, or TNFSF-15 is disclosed. A method for monitoring the effectiveness of such therapy is also disclosed. Furthermore, a method of screening compounds for use in the treatment of rheumatoid arthritis... Agent: Knobbe Martens Olson & Bear LLP

20100279280 - Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases: The invention provides methods and reagents for detecting a polymorphism associated with in an upstream region of the interleukin-1 beta (IL-B) gene (IL-1B (−3737)) that affects transcription of the gene and susceptibility to inflammatory and infectious diseases such as periodontal disease and Alzheimer's disease.... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100279291 - Gene silencing of the brother of the regulator of imprinted sites (boris): The present invention provides methods and compositions useful for inhibiting expression of the gene encoding the transcription factor, Brother of the Regulatory of Imprinted Sites (BORIS) by RNA interference. Methods of the present invention can be used to silence BORIS in cancer cells, which results in apoptosis and may be... Agent: The Law Office Of Jane K. Babin Professional Corporation

20100279285 - Genetic markers of mental illness: This invention relates to genetic markers of mental illness, e.g., schizophrenia (SZ), and methods of use thereof.... Agent: Fish & Richardson PC

20100279297 - Method for identifying an increased susceptibility to ulcerative colitis: A method is provided for detecting an increased susceptibility to ulcerative colitis by determining the presence of a polymorphism at position 256 of the nucleotide sequence of rs3024505 in which C is substituted by T or the presence of a polymorphism at position 501 of the nucleotide sequence of rs12612347... Agent: Diederiks & Whitelaw, PLC

20100279283 - Method for molecular biology applications: The invention provides a method of nucleic acid synthesis and/or amplification, and/or of improving the efficiency, activity and/or stability of at least one nucleic acid-modifying enzyme, comprising carrying out the method in the presence of (a) at least one organic-based macromolecule having a molecular weight of 50 kDa to 500... Agent: Remenick PLLC

20100279284 - Method for selecting hop line and breeding marker and primer set used for selecting hop line: It is an object of the invention to screen for hop varieties with low cohumulone ratio and low colupulone ratio, as well as hop varieties with high contents of farnesene and/or linalool within a short time period utilizing a molecular screening method that employs a breeding marker. The invention provides... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100279288 - Method for sequencing nucleic acid molecules: The sequence of a target polynucleotide can be determined by: (i) contacting the target polynucleotide with a polymerase enzyme and one of the nucleotides A, T(U), G and C under conditions suitable for the polymerase reaction to proceed; (ii) measuring the time taken for the polymerase to bind to and... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100279286 - Method of detecting equine polysaccharide storage myopathy: The present invention relates to diagnosing Polysaccharide Storage Myopathy (PSSM) disease in equines.... Agent: Viksnins Harris & Padys Pllp

20100279281 - Method of identifying lung cancers associated with asbestos-exposure: The present invention is related to a method for assessing the presence of, or disposition to, an asbestos-related disorder in a subject. Particularly, the invention provides a method of identifying lung cancers associated with asbestos-exposure. The association is confirmed by the detection of allelic imbalance (AI) in at least one... Agent: Birch Stewart Kolasch & Birch

20100279298 - Methods and compositions for detecting autoimmune disorders: The invention provides methods and compositions useful for detecting autoimmune disorders.... Agent: Genentech, Inc.

20100279301 - Methods and compositions for diagnosing bladder cancer: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to genes and gene panels as diagnostic markers and clinical targets for bladder cancer. Methods, compositions, and kits for diagnosing, determining, and determining... Agent: Casimir Jones, S.c.

20100279293 - Methods and compositions for identifying increased risk of developing fragile x-associated disorders: The present invention provides compositions and methods of identifying a subject as having an increased risk of developing fragile X-associated tremor and ataxia syndrome (FXTAS) or identifying a subject having an increased risk of developing fragile X syndrome (FXS), comprising analyzing messenger RNA (mRNA) transcripts and/or translation products of the... Agent: Myers Bigel Sibley & Sajovec

20100279300 - Methods for determining the prognosis for patients with a prostate neoplastic condition: The invention provide a method of identifying a biomarker that is diagnostic for survival of a patient with a prostate neoplastic condition. The method consists of (a) measuring the level of IAPs in a neoplastic prostate cell-containing sample from patients with a prostate neoplastic condition, and (b) identifying a correlation... Agent: Mcdermott, Will & Emery

20100279282 - Methods for genotyping mature cotton fibers and textiles: Methods for distinguishing between cotton cultivars of a specific species by analyzing a sample of mature cotton fibers from raw cotton materials or from textile goods are disclosed. DNA is extracted from the mature cotton fiber sample and subjected to PCR techniques which enable the identification of the cultivar of... Agent: KerrIPGroup, LLC Michael A. Kerr

20100279304 - Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation: This invention describes methods for the generation of nucleic acid probes that improve the sensitivity of hybridization assays. The sensitivity increase results from structural modifications of nucleic acids that promote network formation during hybridization with the result that a single target molecule becomes attached to a complex of many probe... Agent: Klarquist Sparkman, LLP

20100279294 - Methods of detecting and genotyping escherichia coli o157:h7: A method for detecting and genotyping Escherichia coli O157:H7 strains, including detecting nucleotides at single nucleotide polymorphism (SNP) loci, the identity of which nucleotides define SNP genotypes. A method for genotyping E. coli O157:H7 strains, including detecting thirty-two nucleotides at thirty-two single nucleotide polymorphism (SNP) loci, the identity of which... Agent: Price Heneveld Cooper Dewitt & Litton, LLP

20100279278 - Methods of detecting one or more bioterrorism target agents: The present invention provides a methods and compositions for early diagnosis of exposure to or infection by a chemical or biological weapon by rapid and specific detection of one or more bioterrorism target agents in a sample.... Agent: Steven B. Kelber Berenato & White, LLC

20100279302 - Methods of predicting pairability and secondary structures of rna molecules: Provided are methods of predicting a pairability of nucleotides of a plurality of RNA polynucleotides by (a) simultaneously determining a paired state or an unpaired state of nucleotides of the plurality of RNA polynucleotides; and (b) corresponding the paired state or the unpaired state of the nucleotides to a database... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100279292 - Microrna expression in human peripheral blood microvesicles and uses thereof: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of disorders by examining samples containing microvesicles and miRs therein.... Agent: Macmillan Sobanski & Todd, LLC

20100279303 - Reaction vessel, reaction vessel liquid introducing device, liquid introducing and reaction measuring device, and liquid introducing device: The invention relates to a reaction vessel, a reaction vessel liquid introducing device, a liquid introducing and reaction measuring device, and a liquid introducing device, and is directed to being able to perform temperature control of a liquid stored within the reaction vessel with a high accuracy and faithful responsiveness.... Agent: Haynes And Boone, LLPIPSection

20100279289 - Size-dependent biological effect of nanoparticles: Nanoparticles are used increasingly in consumer products and biomedical applications. Yet the cellular interaction mechanism at the molecular level is not well understood for nanomaterials of different size, shape and surface chemistry. Gold nanoparticles (Au-NPs), which have been explored extensively for various applications in recent years, are used as the... Agent: Weaver Austin Villeneuve & Sampson LLP

20100279295 - Use of thermostable endonucleases for generating reporter molecules: Provided are compositions and methods for amplifying, capturing and/or detecting target nucleic acids using cleavable oligonucleotides.... Agent: Grant Anderson LLP C/o Portfolioip

20100279306 - Analysis of phosphorylated glycans, glycopeptides or glycoproteins by imac: The present disclosure provides technologies for enriching, detecting, and/or quantifying phosphorylated glycans and/or glycoconjugates (e.g., glycopeptides, glycolipids, proteoglycans, etc.). Specifically, the present disclosure provides methods that utilize immobilized metal affinity chromatography (IMAC) to isolate and/or to characterize phosphorylated glycans. The present disclosure particularly provides methods for distinguishing sulfated and phosphorylated... Agent: Choate, Hall & Stewart LLP

20100279307 - Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer: The present invention relates to a method for providing molecules that are capable of inhibiting angiogenesis, comprising the steps of providing a range of molecules; testing whether these molecules can prevent interaction between JAM-B and JAM-C; testing the positive molecules for their ability to block angiogenesis in vivo; and selecting... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100279310 - Assay device and method: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the... Agent: Harvard University & Medical School C/o Wolf, Greenfield & Sacks, P.C.

20100279311 - Method for screening of cell-protecting agent: The invention provides a screening method and screening kit for a cell protecting agent. Specifically, the invention provides a method for screening a cell protecting agent showing an Hsp90-binding activity and a heat shock protein expression-inducing activity but having no Hsp90 client protein degradation-promoting activity. The method comprises the following... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100279309 - Microfluidic chips and systems for analyzing protein expression, and methods of use thereof: Microfluidic chips, systems including at least one integrated microfluidic chip operably connected to hardware (e.g., docking device, high voltage electrodes, portable fluorescence microscope, computer, etc.), and methods for analyzing peptides (e.g., toxins), proteins (e.g., cancer biomarkers, recombinant human growth hormone, recombinant human erythropoietin), and protein expression in biological samples (e.g.,... Agent: Gregory A. Nelson Novak Druce & Quigg LLP

20100279308 - Rapid lateral flow glycan-detecting device: A glycan-detecting device containing a sample pad, a membrane in communication with the sample pad, a labeled lectin, an immobilized lectin of the same type, and an immobilized antibody specific to the lectin.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100279312 - Method of screening apoptosis accelerating compound or anti-apoptotic compound and method of determining malignancy of neurodegenerative disease: Screening methods for determining pro-apoptotic compounds or anti-apoptotic compounds comprise measuring the interaction between p53 and NEDL1 in the presence and in the absence of a test compound, and comparing the strength of interaction between p53 and NEDL1 in the presence and in the absence of the test compound.... Agent: Sughrue Mion, PLLC

20100279313 - Novel secreted immunomodulatory proteins and uses thereof: The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes. Accordingly, in one aspect, this invention provides isolated nucleic acid molecules encoding a polypeptide of the invention or biologically active portion thereof. The present invention also provides nucleic acid... Agent: Millennium Pharmaceuticals, Inc.

20100279316 - Antibodies to phosphorylated irak4: The present invention relates to antibodies that bind phosphorylated forms of IRAK4, methods of using such antibodies to detect IRAK4 biological activity, and methods for the detection, diagnosis, and prognostication of pathological conditions related to IRAK4 biological activity. ERAK4 is one member of a small family of highly conserved cytoplasmic... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20100279317 - Method: The present invention provides a method for identifying a single or group of T cell receptors (TCR) protective and/or effective against a disease, having the following steps: i) obtaining T cells from a donor non-human animal; ii) adoptive transfer of the T cells into a plurality of T cell-deficient recipient... Agent: Marshall, Gerstein & Borun LLP

20100279318 - Method of identifying transmembrane protein-interacting compounds: A method for screening compounds for their ability to interact with transmembrane proteins is provided. Also provided is a method for determining whether proteins such as transmembrane proteins are able to oligomerise. The method uses a transmembrane protein that comprises a nuclear localization sequence (NLS)... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20100279319 - Detection of plasmodium falciparum histidine-rich protein ii in saliva malaria patients: The detection of PfHRP II in saliva offers a practical, cost-effective alternative to PfHRP II detection in blood as a means for diagnosis of malaria. Collection of saliva is non-invasive, simple, safe, stress free, painless and can be accomplished in primitive settings. The use of Malaria Antigen ELISA kits (CELISA,... Agent: Morris Manning Martin LLP

20100279322 - Direct detection of intracellular fluorescently tagged cells in solution: A method of detecting target cells and pathogens in a test sample concentrates to target cells in solution by filtering or capturing the target cells on a solid support. The target cells are tagged with a fluorescent dye and dispersed in a solution or suspension. The resulting solution or suspension... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100279320 - High-throughput cell transfection device and methods of using thereof: Transfecting biology cells with nucleic acid molecules (DNA, siRNA) is an essential prerequisite in elucidating how genes function in complex cellular context and how their activities could be modulated for therapeutic intervention. Traditionally studies are carried out on a low throughput gene-by-gene scale, which has created a huge bottleneck in... Agent: Wilson, Sonsini, Goodrich & Rosati

20100279323 - Method for predicting response to epidermal growth factor receptor-directed therapy: This invention provides methods for determining or predicting response to cancer therapy in an individual.... Agent: Amgen Inc.

20100279321 - Methods and apparatus for the isolation and enrichment of circulating tumor cells: Embodiments in accordance with the present invention relate to methods and apparatuses for concentrating and isolating Circulating Tumor Cells (CTCs) from body fluids. One embodiment of the present invention includes a micro-fabricated or nano-fabricated device having channels configured for separating and excluding. Embodiments in accordance with the present invention utilize... Agent: Townsend And Townsend And Crew, LLP

20100279324 - Assay for detecting mycobacterial infection: Methods for assessing a mycobacterial infection in a subject comprise exposing at least one CD1 molecule or analogue to mycolic acid or a mycolic acid analogue, subsequently incubating the at least one CD1 molecule or analogue with a sample comprising at least one T cell isolated from the subject, and... Agent: Ratnerprestia

20100279314 - Composition and method for measuring thallium influx and efflux: The present invention relates to methods for detecting the activity of an ion channel in a cell. The methods comprise providing a loading buffer solution to a cell that has an ion channel. The loading buffer comprises at least one thallium indicator (e.g., an environmentally sensitive, luminescent dye) and a... Agent: Life Technologies Corporation C/o Intellevate

20100279315 - Improved method for prenatal diagnosis: The invention discloses a method of prenatal diagnosis comprising the step of isolating exosomes from an isolated fluid, wherein the exosomes are identified by biomarker detection. Furthermore, the invention discloses the isolation of exosomes from an isolated fluid and the use of a biomarker, particularly CD24 to isolate exosomes from... Agent: Foley And Lardner LLP Suite 500

20100279325 - Use of modified extracellular matrix proteins in diagnosis and treatment of atherosclerosis: The present invention relates to the use of fibronectin, tenascin, collagens type I, III, VI and/or VIII modified by aldehyde or by glycosylation in ELISA for detection of antibodies in plasma and serum to diagnose atherosclerosis as well as the use of induction of tolerance and active as well as... Agent: Gauthier & Connors, LLP

20100279326 - Method for determining the concentration of an analyte in a fluid: A total transmission spectroscopy system for use in determining the analyte concentration in a fluid sample comprises a sample cell receiving area, a light source, a collimating lens, a first lens, a second lens, and a detector. The sample cell receiving area is adapted to receive a sample to be... Agent: Nixon Peabody LLP

20100279327 - Method of treating diseases with parp inhibitors: The present invention discloses various diseases that have up-regulated or down-regulated PARP and can be treated with PARP inhibitors or PARP activators, respectively. The examples of the diseases include cancer, inflammation, metabolic disease, CVS disease, CNS disease, disorder of hematolymphoid system, disorder of endocrine and neuroendocrine, disorder of urinary tract,... Agent: Bipar Sciences Inc. C/o Morrison Foerster

20100279328 - Fret assays, methods for performing the assays and compounds relevant to the assays: The present invention is generally directed to biological assays. More specifically it is directed to FRET-based assays using particularly effecting FRET pairs, methods for performing such assays and the molecules utilized in the assays. In a composition aspect, the present invention is directed to a FRET-based protease substrate selected from... Agent: Jeffrey A. Mckinney Mckinney Law Group Apc

20100279330 - Method for detecting and/or identifying clostridium difficile: e

20100279329 - Method for the stabilisation of purified p-glycoprotein: There is provided a method for producing purified P-glycoprotein (P-gp) in a stabilised form such that, after being reconstituted into proteoliposomes, it can be freeze dried and stored for prolonged periods of time without loss of biological activity The method comprises the steps of: i) solubilising a mixture of P-gp... Agent: Volpe And Koenig, P.C.

20100279331 - Novel transporter protein in mammal and utilization of the same: The present invention provides a lipid membrane that contains a polypeptide consisting of the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, or 22. Use of the present invention enables screening for a chemical which regulates excretion of a chemical and/or a waste. Furthermore, use of the... Agent: King & Spalding

20100279335 - Apparatus for measuring blood oxygen saturation: e

20100279337 - Biomarkers related to metabolic age and methods using the same: Biomarkers relating to metabolic age are provided, as well as methods for using such biomarkers as biomarkers for determining metabolic age. In addition, methods for modulating the metabolic age of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for metabolic age.... Agent: Brinks, Hofer, Gilson & Lione

20100279334 - Cyclodipeptide synthases (cdss) and their use in the synthesis of linear dipeptides: Use of CDSs in the synthesis of linear dipeptides, and applications thereof for the in vivo and in vitro synthesis of linear dipeptides, in particular Phe-Leu, Leu-Phe, Phe-Phe, Phe-Tyr, Tyr-Phe, Leu-Leu, Leu-Tyr, Tyr-Leu, Phe-Met, Met-Phe, Leu-Met, Met-Leu, Tyr-Met, Met-Tyr, Met-Met, Tyr-Tyr, Ile-Met, Met-Ile, Leu-Ile, Ile-Leu using the corresponding polynucleotides.... Agent: The Nath Law Group

20100279332 - Method and device for characterizing biological tissue: A method and a system for jointly determining the content of a first chromophorous and fluorescent compound and a second chromophorous compound in a biological tissue (30). The determination of the content of the chromophorous and fluorescent compound (33) is carried out by optical measurement of the differential absorption of... Agent: Young & Thompson

20100279336 - Method for rapidly measuring premature yeast flocculating factor of malt and measuring apparatus therefor: This invention provides a method for rapidly measuring an premature yeast flocculating factor of malt contained in a brewing material, comprising the following steps of: (1) mixing yeast in the late logarithmic growth phase or thereafter with a water-extracted high molecular fraction prepared from a test material sample in a... Agent: Foley And Lardner LLP Suite 500

20100279333 - Methods of treatment with antibodies to a chemokine expressed in inflamed adenoid: The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically... Agent: Foley And Lardner LLP Suite 500

20100279339 - Apparatus and method for detecting bacterial growth beneath a wound dressing: An apparatus and method are provided for visually monitoring, detecting, and/or determining the presence, absence, and/or growth of harmful or potentially harmful bacterial microorganisms beneath a wound dressing, in one example used to cover an indwelling central venous catheter or other catheter. A bacteria detection apparatus includes a barrier membrane,... Agent: Swiss Tanner, P.C. P.o. Box 1749

20100279338 - Cell carrier coding: There are provided cell carrier devices for use in cell observation systems, enabling determination of the location of the region under observation by virtue of coding information present in the field of view of the viewing device, even at high magnification. Other embodiments are also disclosed.... Agent: Daniel Feigelson

20100279340 - Imaging agents for protein misfolding: Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styryl molecules are prepared using acetic anhydride catalyzed reactions, Horner-Emmons reactions or Wittig reactions.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100279341 - Methods and system for analyzing cells: The invention relates to a method for analyzing cells that are present as closed clusters. According to said method, a planar tissue preparation is subjected to an identification staining of the cell nuclei and a target structure staining of cell objects that is different from the identification staining. Digital images... Agent: Lerner Greenberg Stemer LLP

20100279342 - Thin-section slides manufacturing apparatus and method for manufactring thin-section slides: A thin-section slide-sample manufacturing apparatus and a method for manufacturing a thin-section slide sample by cutting out a thin section from an embedded block, transporting the thin section on a conveyor unit, transferring and mounting the thin section on a substrate, the thin-section slide-sample manufacturing apparatus including: a relay having... Agent: Brinks Hofer Gilson & Lione/seiko Instruments Inc.

20100279343 - Method for producing alpha-l-aspartyl-l-phenylalanine-beta-ester and method for producing alpha-l-aspartyl-l-phenylalanine-alpha-methyl ester: A method of producing an α-L-aspartyl-L-phenylalanine-β-ester by forming the α-L-aspartyl-L-phenylalanine-β-ester from L-aspartic acid-αβ-diester and L-phenylalanine using an enzyme or enzyme-containing substance that has an ability to selectively link L-phenylalanine to an α-ester site of the L-aspartic acid-αβ-diester through a peptide bond.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100279345 - Aut0-inducible sodium phosphate symporter promoter from pichia pastoris and method for producing recombinant protein using it: Disclosed herein are a Pichia pastoris-derived auto-inducible NPS promoter; a recombinant expression vector carrying the promoter and a nucleotide sequence, the sequence being operably linked to the promoter and coding for a recombinant protein; a host cell transformed or transfected with the recombinant expression vector; and a method for producing... Agent: Holme Roberts & Owen LLP

20100279350 - C-type lectin polypeptide, polynucleotide and methods of making and use thereof: Provided herein are polypeptide and polynucleotide sequences for a molecule having homology to the C-type lectin family of polypeptides. Also provided are methods of making and using the polypeptide and polynucleotides.... Agent: Immunex Corporation Law Department

20100279346 - Compositions and methods for improved protein production: The present invention relates to the identification of novel nucleic acid sequences, designated herein as 7p,8k, 7E, 9G, 8Q and 203, in a host cell which effect protein production. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding 7p,8k,... Agent: Danisco US Inc. Attention: Legal Department

20100279344 - Integrated cytokine production system: A multi-stage method for producing a cytokine involves expressing the cytokine in an expression system, preferably a Bacillus subtilis strain from which at least 7, and preferably at least 8, extra-cellular proteases have been eliminated that additionally provides a significantly increased expression and secretion of the desired cytokine, subsequently purifying... Agent: Fitch, Even, Tabin & Flannery

20100279349 - Nucleic acids encoding two-component sensing and regulatory proteins, antimicrobial proteins and uses therefor: Stress-related nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, stress-related fusion proteins, antigenic peptides, and anti-stress-related antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells into which the expression... Agent: Alston & Bird LLP

20100279347 - Polymyxin synthetase and gene cluster thereof: The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from Paenibacillus polymyxa E681, ATCC21830 and F4 strains, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the... Agent: Greenlee Sullivan P.C.

20100279348 - Yeast strains for protein production: Method and system for expression systems, based on ade1 and ade2 auxotrophic strains of yeast and fungi, including P. pastoris are disclosed. The expression systems are useful for increased cellular productivity of transformed cell lines and for production of recombinant glycoproteins at industrial scale.... Agent: Merck

20100279351 - Method for generation of antibodies: This invention generally relates to methods for the production of antibody producing cells and antibodies in protooncogene expressing animals. The invention also relates to methods for the efficient production of antibodies specific for antigens that are normally subject to immunological constraints such as self tolerance. The invention further relates to... Agent: Wilson, Sonsini, Goodrich & Rosati

20100279352 - Rapid generation of antibodies: High efficient methods for producing an antibody molecule that binds an antigen are described. The methods include obtaining a population of PBMC enriched for CD19highCD3negCD20low to negCD38highCD27high cells from a mammal exposed to an antigen from sample of cells enriched for PBMC. The cells are isolated from a sample obtained... Agent: Fish & Richardson PC

20100279353 - Process of producing fibrinolytic enzyme from mushroom: A fibrinolytic enzyme isolated from a culture broth of a mushroom has a characteristic of degrading a fibrin and a fibrinogen without activating an activity of a plasminogen. The plasminogen is activated to generate a plasmin to degrade the fibrin and/or fibrinogen, so that the fibrinolytic enzyme be used for... Agent: David And Raymond Patent Firm

20100279354 - Adapting microorganisms for agricultural products: Disclosed herein are methods and compositions to convert a carbonaceous material to produce a fatty acid, biofuel, biodiesel, or other useful end-product. Organisms are evolutionarily modified to utilize carbon and/or nitrogen sources available in a carbonaceous material. Culture of the evolutionarily modified organism on the carbonaceous material in turn produces... Agent: Wilson, Sonsini, Goodrich & Rosati

20100279355 - Beta 1,3-n-acetyl-d-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with β1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes... Agent: Nixon & Vanderhye, PC

20100279356 - Production of sialylated n-glycans in lower eukaryotes: The present invention relates to eukaryotic host cells which have been modified to produce sialylated glycoproteins by the heterologous expression of a set of glycosyltransferases, including sialyltransferase and/or trans-sialidase, to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. Novel eukaryotic host cells expressing a CMP-sialic acid biosynthetic... Agent: Merck

20100279357 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent: Husch Blackwell Sanders, LLP Husch Blackwell Sanders LLP Welsh & Katz

20100279358 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent: Husch Blackwell Sanders, LLP Husch Blackwell Sanders LLP Welsh & Katz

20100279359 - Template-dependent nucleic acid polymerization using oligonucleotide triphosphates building blocks: A novel use of a template-dependent polymerase. The novel use is effected by employing the template-dependent polymerase for incorporating at least one oligonucleotide triphosphate onto a nascent oligonucleotide-3′-OH in a template-dependent manner.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100279360 - Sso7-polymerase conjugate proteins: This invention provides Sso7-polymerase conjugates that exhibit improved activity in a polymerase reaction.... Agent: Townsend And Townsend And Crew, LLP

20100279361 - Two-stage method for pretreatment of lignocellulosic biomass: One aspect of the invention relates to a process, comprising treating lignocellulosic biomass according to a first pretreatment protocol, thereby generating a first product mixture; separating the first product mixture into a first plurality of fractions; and treating at least one fraction of said first plurality of fractions according to... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20100279362 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the ybiv gene: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the ybiV gene.... Agent: Cermak Nakajima LLP Acs LLC

20100279363 - L-glutamic acid-producing bacterium and method for production of l-glutamic acid: A method for producing L-glutamic acid by culturing a coryneform bacterium in which the gluX is inactivated in a medium to produce L-glutamic acid in the medium or cells, and collecting L-glutamic acid from the medium.... Agent: Cermak Nakajima LLP Acs LLC

20100279364 - Cci-779 derivatives and methods of making same: A method of generating synthetic metabolites of CCI-779 is provided. Five novel CCI-779 derivatives are described, as are methods of using these derivatives for detecting CCI-779 metabolites in samples.... Agent: Howson & Howson LLP / Wyeth LLC

20100279365 - Novel aldolase and production process of substituted alpha-keto acids: 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100279366 - Fungal peroxygenases and methods of application: The invention relates to polypeptides having peroxygenase activity and compositions comprising such polypeptides, their encoding polynucleotides, expression vectors and recombinant host cells comprising such polynucleotides or vectors, methods of producing the polypeptides, as well as methods of application and uses thereof, including a process for enzymatic, regioselective oxygenation of N-heterocycles... Agent: Novozymes North America, Inc.

20100279367 - Soybean-based fermentation media, methods of making and use: Fermentation media containing an isoflavone-depleted soybean meal or isoflavone-depleted soybean meal product and at least one exogenous added ingredient that comprises a substrate for microbial growth are provided. Methods of making a fermentation medium comprising an isoflavone-depleted soybean meal or isoflavone-depleted soybean meal product and methods for obtaining a fermentation... Agent: Thompson Coburn LLP

20100279368 - Biocatalystic synthesis of quinic acid and conversion to hydroquinone by recombinant microbes: A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as conversion of quinic acid to hydroquinone are also provided.... Agent: Proskauer Rose LLP

20100279369 - Metabolically engineered microorganism useful for the production of acetol: b

20100279370 - Method for controlling butanol concentration in fermentation broth: The present invention relates to a two stage process to control the butanol concentration from fermentation broth.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100279371 - Processes of producing fermentation products: The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein increased levels of one or more pyrophosphatase enzymes are present in the fermentation medium.... Agent: Novozymes North America, Inc.

20100279372 - Method of pretreating lignocellulose-based biomass: Disclosed is a method of pretreating lignocellulose-based biomass by extracting lignin from biomass by adding a solvent for dissolving lignin to the lignocellulose-based biomass including lignin, hemicellulose and cellulose, and extracting the cellulose and/or hemicellulose by adding an ionic liquid to the remaining biomass after extracting the lignin.... Agent: Cantor Colburn, LLP

20100279373 - Device and process for treating a liquid medium: A device for treating liquid medium has an ultrasound emitter located relative to a compartment of a container holding a liquid medium and a microbubble emitter located relative to the compartment. The ultrasound emitter emits high-frequency ultrasound between about 200 KHz and 10 MHz. The microbubble emitter emits bubbles with... Agent: Knobbe Martens Olson & Bear LLP

20100279374 - Manipulation of beads in droplets and methods for manipulating droplets: The invention provides a method of dispersing or circulating magnetically responsive beads within a droplet in a droplet actuator. The invention, in one embodiment, makes use of a droplet actuator with a plurality of droplet operations electrodes configured to transport the droplet, and a magnetic field present at a portion... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20100279375 - Method for producing immobilized enzyme: A method for producing an immobilized enzyme which includes the steps of immobilizing an enzyme used for hydrolyzing fats and oils on a immobilization carrier by adsorption, bringing the immobilized enzyme into contact with an organic solvent in which fat-soluble fatty acids or the derivatives thereof have been dissolved, and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100279377 - Biosensors and methods for making and using them: Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include... Agent: Gates & Cooper LLP Howard Hughes Center

20100279376 - Preparation of solvent-borne polymeric bioactive coatings: Processes for preparation of a protein-polymer composite material are provided according to embodiments of the present invention which include providing an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins and substantially free of surfactant is mixed with the admixture. The... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20100279378 - Mek ligands and polynucleotides encoding mek ligands: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate MEK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100279379 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent: Husch Blackwell Sanders, LLP Husch Blackwell Sanders LLP Welsh & Katz

20100279380 - Methods for degrading toxic compounds: The invention relates to bacteria, bacterial extracts, supernatants obtained from the culturing of said bacteria, polypeptides and compositions for degrading benzimidazole carbamate fungicides, carbanilate fungicides, sulfonamide herbicides, thioamide herbicides and/or synthetic pyrethroid insecticides. In particular, the invention relates to the identification of Nocardioides sp. which degrades benzimidazole carbamate fungicides, carbanilate... Agent: Bozicevic, Field & Francis LLP

20100279381 - Acetylcholinesterase (ache) variants of the n-terminus: A novel form of acetylcholinesterase (AChE) is provided, N-AChE, which bears a transmembrane domain. Exons encoding this novel form, the peptide comprising, the transmembrane domain, as well as antibodies recognizing the same are also provided. N-AChE expression in the hippocampus is correlated with Alzheimer's disease. Secreted forms of AChE are... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100279382 - Compositions and methods for quantification of serum glycoproteins: The invention provides compositions and methods for identifying and/or quantifying glycopolypeptides from human serum or plasma. The compositions and methods include a plurality of standard peptides containing glycosylation sites determined for human serum/plasma proteins.... Agent: Mcdermott, Will & Emery

20100279383 - Subtilases and subtilase variants having altered immunogenicity: The present invention relates to subtilase variants and subtilases with an altered immunogenicity, particularly subtilase variants and subtilases with a reduced allergenecity. Furthermore, the invention relates to expression of said subtilase variants and subtilases and to their use, such as in detergents and oral care products.... Agent: Novozymes North America, Inc.

20100279384 - Isolated reductive dehalogenase genes: The invention is directed to novel reductive dehalogenase genes encoding for reductive dehalogenases which are capable of dehalogenating halogenated organic compounds and may be useful in the bioremediation of pollutants. In particular, the invention provides an isolated polynucleotide of a novel vinyl chloride dehalogenase gene (bvcA). The novel vinyl chloride... Agent: Fenwick & West LLP

20100279386 - Modified vaccinia ankara virus variant and cultivation method: The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a... Agent: Law Office Of Salvatore Arrigo

20100279385 - Purification of adenovirus and aav: The present invention relates to the purification of large scale quantities of active (infectious) adenovirus and AAV, especially for use in therapeutic applications. In particular, the invention provides improved methods for contacting such viruses with suitable chromatographic materials in a fashion such that any damage to the virus, particularly to... Agent: Genzyme Corporation Legal Department

20100279387 - Method for remediation of soil containing cyanogen compound, and microorganism for use in the remediation method: The present invention relates to a method for remediation of a cyanogen compound contained in a soil efficiently and reliably. The method comprises adding a microorganism which belongs to the genus Arthrobacter sp., which is capable of degrading the cyanogen compound and which can act as a degradation-accelerating factor to... Agent: Sughrue Mion, PLLC

20100279388 - Agent for treating mildew and method for treating mildew: It is intended to provide an agent for treating fungi which is capable of controlling the production cost while using a microorganism with high safety, and also maintaining an adhesion state on a surface of a target for a predetermined period of time or longer during use, and a method... Agent: Chapman And Cutler

20100279389 - Modular algae culturing system and method: A modular algae culturing system and method are described. The system utilizes modular, vertically-oriented growth units that can be connected together in series or parallel (or any combination thereof). Each unit comprises: a back plate opposite a front plate, an input side wall opposite an output side wall, and a... Agent: David Ziller

20100279390 - Methods for transforming eukaryotic algae: Compositions and methods for genetically modifying algae or other photosynthetic eukaryotes to express an alcohol producing enzyme, such as pyruvate decarboxylase (PDC) and alcohol dehydrogenase (ADH) or any other enzymes that also synthesizes methanol, ethanol or butanol are provided. These enzymes are engineered to contain chloroplast targeting sequences which efficiently... Agent: Fenwick & West LLP

20100279391 - Method and system for removing co2 from the atmosphere: A system for removing gaseous pollutants from air enriched with the pollutants includes a cultivation environment configured to cultivate vegetation under exposure to pollutant enriched air, and a transformation unit configured to transform an encapsulation material to a transitory viscous or liquid state. Further, the system includes a mixing unit... Agent: Dickinson Wright PLLC

20100279392 - Container for liquid reaction mixture, reaction-promoting device using the same and method therefor: A container for a liquid reaction mixture whereby the liquid reaction mixture is brought into contact with a heater at a specified temperature and thus a nucleic amplification reaction is promoted, which has a substrate having a front surface and a back surface and being constructed so that either or... Agent: Konomi Takeshita

20100279394 - Method of component assembly on a substrate: A method of component assembly on a substrate, and an assembly of a bound component on a substrate. The method comprises the steps of forming a free-standing component having an optical characteristic; providing a pattern of a first binding species on the substrate or the free standing component; and forming... Agent: Vedder Price P.C.

20100279393 - Micro chip device: In FIG. 2(a), both laminar flows, solution including fine grains and buffer solution, are supplied in a microchannel in a micro chip device, and gel including drug is supplied at a position contacting with the buffer solution. The fine grains in the solution including fine grains starts to react after... Agent: Law Offices Of Robert F. Zielinski, LLC

20100279395 - Systems, apparatuses and methods for cultivating microorganisms and mitigation of gases: Systems, apparatuses, and methods are provided for cultivating microorganisms. In one example, a system may include a plurality of containers for cultivating microorganisms therein. Each container may be adapted to contain water and may include media disposed therein and at least partially submerged in the water. The media may be... Agent: Wildman Harrold Allen & Dixon LLP

20100279396 - Micro-scaled animal cell incubator and production method thereof: There is provided a cell culture technology for culturing an animal cell in a separate microstructure. The micro-scaled animal cell incubator includes a lower glass substrate having fine hot wires processed with a metal and formed in an upper surface thereof; a first PDMS film attached onto the lower glass... Agent: Ampacc Law Group

20100279397 - Biological specimen collection and storage devices: A biological sample containment system and method are provided that include a container for storing the biological sample and an indicator affixed to the container for displaying at least one measured characteristics of the container or sample, wherein measurement of the characteristic is commenced by activation of the indicator. In... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100279398 - Instrument and method for treating minor amount of biological material: Provided is a technique for handling a minor amount of a biological material with the purpose of observing selectively the interaction between single cells by controlling cell number and two- or three-dimensional configurations of each of the different cell types. The present invention provides an instrument and a method for... Agent: J. Rodman Steele Novak Druce & Quigg LLP

20100279399 - Human cancer stem cell culture compositions comprising erbb2 variants and methods of use: The present invention provides compositions and methods for the culture and maintenance of cancer stem cells. More particularly, the present invention provides the identification of cancer stem cell specific markers and methods of recognizing the same for the detection of tumors, for facilitating the prognosis of a patient with a... Agent: The Law Office Of Jane K. Babin Professional Corporation

20100279400 - Diagnostic test for west nile virus: The present invention provides a rapid and sensitive method for the detection of a West Nile virus (WNV), Japanese encephalitis virus (JEV), St. Louis encephalitis virus (SLEV) and Dengue virus (DENV) and antibodies directed against thereof involving contacting a biological specimen suspected of being infected with WNV, JE, SLE or... Agent: Frommer Lawrence & Haug

20100279401 - T cell hybridomas and related compositions and methods for assaying and modulating t cell receptor-mediated immune responses: The present invention provides T cell hybridomas and related compositions and assay systems for investigative, diagnostic, and therapeutic use in modulating T cell receptor (TCR)-mediated immune response. The T cell hybridomas of the invention are typically constructed by fusing a naïve or early central memory T cell isolated from a... Agent: Jeffrey J. King, Esq. Patent Networks Law Group PLLC

20100279403 - Differentiation of pluripotent cells: Provided herein are methods for the in vitro maintenance, expansion, culture, and/or differentiation of pluripotent cells, such as human embryonic stem cells (hESC) or induced pluripotent cells (iPSC), into hematopoietic precursor cells or endothelial cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of... Agent: Fulbright & Jaworski L.L.P.

20100279402 - Expression construct for digesting aggregating protein and method of inhibiting the aggregation of aggregating protein: It is intended to provide a means which is efficacious in digesting a protein forming aggregates in a eukaryotic cell such as mutant superoxide dismutase 1 or an androgen receptor having an abnormally extended polyglutamine chain. Namely, an expression construct for digesting an aggregating protein which has a nucleic acid... Agent: Edwards Angell Palmer & Dodge LLP

20100279404 - Method of nuclear reprogramming: This invention provides a method of producing an induced pluripotent stem cell comprising the step of introducing at least one kind of non-viral expression vector (more preferably a plasmid vector) incorporating at least one gene that encodes a reprogramming factor into a somatic cell. An induced pluripotent stem cell wherein... Agent: Knobbe Martens Olson & Bear LLP

20100279405 - Systems, methods and compositions for optimizing tissue and cell enriched grafts: Disclosed herein are methods and systems for the concentration of cells from a cell suspension into unprocessed tissue, such as adipose tissue. Also disclosed herein are systems for optimizing hydration of tissue and cell enriched grafts.... Agent: Knobbe Martens Olson & Bear LLP

20100279407 - Alpha 1-acid glycoprotein, alpha 2-hs glycoprotein, alpha 1-antitrypsin, and fragments thereof induce apoptosis in cancer cell lines: This invention characterizes the selective apoptotic activity of specially prepared zinc charged alpha 1-acid glycoprotein, alpha 2-HS glycoprotein, and alpha 1-antitrypsin. These proteins cause apoptosis in cancer cells while leaving normal cells intact. In addition, active fragments of zinc charged alpha 1-acid glycoprotein and alpha 2-HS glycoprotein, whether manufactured from... Agent: Trojan Law Offices

20100279406 - Alteration of tumor growth using zinc finger proteins: The present invention provides methods for altering tumor growth using zinc finger proteins.... Agent: Robins & Pasternak

20100279410 - Compounds for the treatment of proliferative disorders: e

20100279409 - Method for modifying celluar immune resonse by modulating activin activity: The invention relates to methods for modifying a cellular response, such as a CD8+ T cell or NK cell response, by adding an activin modulator in an amount sufficient to modulate activin production. By modulating this production, the cellular response is itself modulated.... Agent: Fulbright & Jaworski, LLP

20100279408 - Polymeric short interfering rna conjugates: The present invention provides polymeric siRNA conjugates. Methods for down-regulation of gene expression in vivo and in vitro and for inhibition of the growth of cancer cells using the conjugates are also disclosed.... Agent: Lucas & Mercanti, LLP

20100279411 - Combinations of proteins to enhance viability of stem cells and their progenitors before transplantation: Embodiments of the present invention include the use of placental alkaline phosphatase alone or in combination with human transferrin and, optionally, human α1-antitrypsin to enhance the proliferation and survival of transplanted stem cells and stem cell-derived progenitor cells.... Agent: Faegre & Benson LLP Patent Docketing - Intellectual Property

20100279412 - Culture medium additive for use in serum-free culturing of animal cell, kit and use thereof: Disclosed are: a culture medium containing a specific growth factor and at least one phospholipid; a composition for preparation of the culture medium; a kit; and a method. A technique can be provided which uses a serum-free or low-serum culture medium and has a promoting effect on the proliferation of... Agent: Mark D. Saralino (general) Renner, Otto, Boisselle & Sklar, LLP

20100279413 - Applications of ubiquinones and ubiquinols: The present invention relates to cell culture medium compositions comprising lipophilic compounds and solubilizing agent and methods of using such compositions for the culturing of cells. The invention also relates to methods of treating disorders of the nervous system such as peripheral neuropathy.... Agent: Morgan, Lewis & Bockius LLP (sf)

20100279414 - Invention concerning the expression and permanent release of canine interleukines: The present invention concerns the production, specific expression, and permanent release of canine interleukines, especially interleukin-2 (cIL-2) or interleukin-12 (cIL-12), from transfected BHK Tet-On cells, as well as the utilization of lymphokin-activated killer cells which were generated therewith for the tumor therapy in dogs.... Agent: Clark & Brody

20100279415 - Lepidopteran insect n-acetylglucosaminidase genes and their use in glycoengineering: A transgenic insect cell line for production of elevated levels of recombinant glycoproteins comprising mammalian-like N-glycans is provided. Also disclosed are nucleic acid sequences encoding β-N-acetylglucosaminidases.... Agent: Dann, Dorfman, Herrell & Skillman

20100279416 - Method for introducing changes into a eukaryotic genome in vivo and a kit: The invention relates to a method for introducing changes into a eukaryotic genome in vivo wherein the HPV genome, which comprises HPV replication origin sequence, is used together with HPV early proteins in order to achieve DNA replication in vivo. There is also disclosed a kit for in vivo amplification,... Agent: Reed Smith LLP

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