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Chemistry: molecular biology and microbiology October categorized by USPTO classification 10/10

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
10/28/2010 > patent applications in patent subcategories. categorized by USPTO classification

20100273141 - Glycine stabilized lyophilized plasma: The invention is directed to stabilized whole-cell plasma, which retains the integrity and overall stability of the proteins and other macromolecules of the plasma. Stabilization is accomplished by the addition of glycine to plasma which allows for stabilization prior to freeze drying. Glycine, in the presence of the salt concentration... Agent: Remenick PLLC

20100273142 - Multi-compartment device with magnetic particles: The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.... Agent: Philips Intellectual Property & Standards

20100273143 - Discriminatory positive/extraction control dna: The present teachings generally relate to methods and kits incorporating a discriminating positive control for determining whether a particular microorganism or group of microorganisms are present in a sample, for example but not limited to a food, environmental, agricultural, biopharmaceutical, pharmaceutical, or water sample. According to certain methods, at least... Agent: Life Technologies Corporation C/o Intellevate

20100273144 - Novel use of grp 94 in virus infection: A novel use of GRP 94 in treatment of virus infection is provided. More specifically, a method of inhibiting virus infection by inhibiting expression of GRP 94 and/or inactivating activity of GRP 94, and a method of developing drugs for preventing and/or treating virus infection and/or diseases caused by virus... Agent: Jhk Law

20100273166 - biosensor device and method of sequencing biological particles: A biosensor device (100) for sequencing biological particles (102), the biosensor device (100) comprising at least one substrate (104), a plurality of sensor active regions (106) provided on each of the at least one substrate (104) and each comprising a primer (108) having a sequence being complementary to a part... Agent: Nxp, B.v. Nxp Intellectual Property & Licensing

20100273174 - Antibodies to tumor associated proteins: A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The... Agent: Agensys C/o Morrison & Foerster LLP

20100273161 - Detection of bacteria belonging to the genus campylobacter by targeting cytolethal distending toxin: The present inventors focused on the cytolethal distending toxin (CDT) of Campylobacter bacteria, and detected the cdt genes of a Campylobacter-like bacterium isolated from an enteritis patient in Thailand. The present inventors discovered a bacterial strain whose cdtB gene was amplified by common primers in C. jejuni, C. coli, and... Agent: Bozicevic, Field & Francis LLP

20100273155 - Determination of quality features in agricultural and horticultural crops: The present invention relates to a method for predicting the expected value of the quality features in agricultural and horticultural product and a method for predicting the expected optimal time of harvest by comparing expression parameters at the moment prior to harvest or during the postharvest path of genes and/or... Agent: Hoffmann & Baron, LLP

20100273153 - Genetic diagnosis of depression: The present invention relates to compositions and methods for determining whether an individual is predisposed to major depressive disorder and/or to bipolar disorder. In particular, the present invention provides genetic markers useful alone or in combination with other genetic markers for the diagnosis, characterization and treatment of major (unipolar) depression... Agent: Morrison & Foerster LLP

20100273151 - Genome-wide analysis of palindrome formation and dna methylation: The present disclosure provides methods for detecting the genome-wide presence of methylated DNA and palindrome formation. The present disclosure also provides methods for specific enrichment of methylated DNA or DNA having a DNA palindrome. These methods have demonstrated that somatic palindromes and methylated DNA occur frequently and are widespread in... Agent: Townsend And Townsend And Crew, LLP

20100273171 - Global gene expression analysis of human bronchial epithelial cells exposed to cigarette smoke, smoke condensates, or components thereof: Aspects of the present invention concern the identification of several methods to analyze the genes that are modulated in normal human bronchial epithelial (NHBE) cells after exposure to cigarette smoke condensates (CSC) or cigarette smoke (CS). Embodiments described herein include methods to identify a gene that is modulated in response... Agent: Knobbe Martens Olson & Bear LLP

20100273158 - Hin-1, a tumor suppressor gene: The invention encompasses isolated DNAs encoding HIN-1 polypeptides, vectors containing such DNAs, cells containing the vectors, and isolated HIN-1 polypeptides. The invention also features methods of making and using HIN-1 polypeptides.... Agent: Fish & Richardson P.C.

20100273147 - Medical diagnostic system and methods: A system and methods are provided for a medical diagnostic system that incorporates a genetically encoded digital signature to authenticate a patient. In an illustrative implementation, a platform is provided performing one or more functions including but not limited to patient authentication, diagnostics, transmission, and storage of data in a... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100273170 - Method and device for preparing biological samples for analysis: The invention relates to a method for preparing biological samples for analysis, comprising the following steps: (a) the biological sample is placed on a two-dimensional support; (b) application of a protein-precipitating or denaturing first solution L1 to the biological sample at a first temperature T1 for a predetermined first time... Agent: Womble Carlyle Sandridge & Rice, PLLC

20100273173 - Method for amplifying target nucleic acid sequence and probe used for the same: The present invention provides a method for amplifying a target sequence while suppressing inhibition of an amplification reaction in nucleic acid amplification in the presence of the probe. At the time of amplifying the target sequence, as the probe caused to coexist in amplification of the target sequence, a probe... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100273168 - Method for discriminating red blood cells from white blood cells by using forward scattering from a laser in an automated hematology analyzer: A method for identifying, analyzing, and quantifying the cellular components of whole blood by means of an automated hematology analyzer and the detection of the light scattered, absorbed, and fluorescently emitted by each cell. More particularly, the aforementioned method involves identifying, analyzing, and quantifying the cellular components of whole blood... Agent: Paul D. Yasger Abbott Laboratories

20100273152 - Method of identifying individuals at risk of thiopurine drug resistance and intolerance: The present invention is directed to a method of screening individuals for the presence or absence of one or more polymorphisms associated with the risk of thiopurine resistance or intolerance.... Agent: Foley & Lardner LLP

20100273175 - Method of judging risk for onset of drug-induced granulocytopenia: e

20100273176 - Method of judging risk for onset of drug-induced granulocytopenia:

20100273167 - Methods for determining prenatal alcohol exposure: Provided herein are methods for determining ethanol exposure of a prenatal subject, including measuring whether or not amniotic fluid stem cells collected from amniotic fluid surrounding the prenatal subject have a upregulation or expression of one or more genes of a first predetermined combination and/or a downregulation of expression of... Agent: Myers Bigel Sibley & Sajovec

20100273163 - Methods for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis: Disclosed are methods for identification of agents that modulate cell attachment, cell migration and cell viability. Cancer and primary cells adhered to a matrix are treated with agent(s) that modulate ActRII signaling and cell adhesion. Agents are tested that modulate cell adhesion, detachment, invasion and viability. Agents that modulate the... Agent: Baker & Hostetler LLP

20100273160 - Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof: The present invention relates to compositions and methods for treating, characterizing and diagnosing ovarian cancer. In particular, the present invention provides methods for treating and/or preventing ovarian cancer in a subject by administering to the subject an effective amount of Mullerian Inhibiting substance and/or an effective amount of an agent... Agent: David S. Resnick

20100273172 - Micrornas expression signature for determination of tumors origin: The present invention provides a process for classification of specific cancers and tumors origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy.... Agent: Foley And Lardner LLP Suite 500

20100273159 - Nested multiplex amplification method for identification of multiple biological entities: The present invention provides a novel molecular method for the simultaneous identification and semi-quantification of multiple targeted biological entities from amongst a plurality. This invention discloses a method based on a multiplex nested amplification reaction in a single closed tube. The first amplification reaction relies on a set of large... Agent: Millen, White, Zelano & Branigan, P.C.

20100273154 - Novel glycosyltransferases and polynucleotides encoding the same: The present invention provides novel glycosyltransferase proteins produced by ascomycetous filamentous fungi (preferably species belonging to the genus Trichoderma, more preferably Trichoderma viride), as well as genes encoding the same. Among novel enzyme proteins provided by the present invention, particularly preferred is an enzyme protein obtained from the culture supernatant... Agent: Greenblum & Bernstein, P.L.C

20100273149 - Photosynthetic hydrogen production from the green alga chlamydomonas reinhardtii: The present invention relates generally to hydrogen production for use in fuel cells, foodstuffs and chemical production, and more particularly, to biologically and photosynthetically produced hydrogen. Specifically, disclosed is a method for producing bacteria and green alga that can produce hydrogen in quantities that exceed four hundred percent of the... Agent: Holme Roberts & Owen LLP

20100273165 - Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses: Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.... Agent: Grant Anderson LLP C/o Portfolioip

20100273169 - Quantitative pcr-based compositions and methods for the diagnosis of invasive pulmonary aspergillosis: Provided are quantitative PCR-based compositions and methods for the diagnosis of invasive pulmonary aspergillosis (IPA) in a patient sample, such as bronchoalveolar lavage (BAL) fluid. The methods presented herein involve isolating a patient sample, optionally extracting DNA from the sample, carrying out a quantitative PCR (qPCR) reaction on the sample... Agent: Schwabe, Williamson & Wyatt, P.C.

20100273162 - Rapid detection of microorganisms: Methods for rapidly detecting Enterobacteriaceae and Micrococcaceae microorganisms utilizing non-amplified nucleic acids, acridiniu labeled ONA probes, and selective growth media are described, particularly for specific microbial species related to the food science industry and public health. Articles of manufacture that include reagents for detecting multiple microorganisms simultaneously are also described.... Agent: 3m Innovative Properties Company

20100273156 - Sequences and methods for detecting influenza a and influenza b virus: Nucleic acid amplification primers and methods for specific detection of influenza A and influenza B nucleic acid targets are disclosed. The primer-target binding sequences are useful for detection of influenza A and influenza B targets in a variety of amplification and hybridization reactions. The oligonucleotide sequences are able to differentiate... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100273150 - Single molecule-format bioluminescent probe: The invention is a single molecule-format bioluminescent probe for detecting a target-specific ligand in a living cell, which comprises, a ligand-binding molecule of which conformation is changed upon binding to the ligand, and an N-terminal polypeptide (N-LE) and a C-terminal polypeptide (C-LE) of a luminescent enzyme (LE), which are linked... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100273157 - System and method for authentication or identification of bio-artifacts related to president abraham lincoln: An invention for authenticating artifacts related to President Abraham Lincoln is presented. In an embodiment of the invention, an artifact is identified. The artifact has a biologically-derived component (“bio-component”). At least a portion of the bio-component is processed to yield matter that may be analyzed. This matter is analyzed and... Agent: John G. Sotos

20100273164 - Targeted and whole-genome technologies to profile dna cytosine methylation: Methods and compositions for determining a methylated cytosine profile of a target nucleic acid sequence are provided.... Agent: Banner & Witcoff, Ltd.

20100273146 - Tb resistance assay: A diagnostic test for detecting multi-drug resistant Mycobacterium sp., in particular Mycobacterium tuberculosis, in a sample is presented, including corresponding reagents, uses thereof and kits therefor.... Agent: Mccracken & Frank LLP

20100273148 - Urine markers for detection of bladder cancer: Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are... Agent: Borson Law Group, PC

20100273145 - Assay method utilizing polynucleotide sequences: A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a... Agent: Enzo Biochem, Inc.

20100273178 - Affinity selected signature peptides for protein identification and quantification: A method for protein identification in complex mixtures that utilizes affinity selection of constituent proteolytic peptide fragments unique to a protein analyte. These “signature peptides” function as analytical surrogates. Mass spectrometric analysis of the proteolyzed mixture permits identification of a protein in a complex sample without purifying the protein or... Agent: Mueting, Raasch & Gebhardt, P.A.

20100273180 - Decorin polypeptide and methods and compositions of use thereof: The present invention provides methods for decreasing expression of a decorin polypeptide in a cell, methods for identifying an agent that alters, preferably decreases, the distribution of decorin polypeptide in a cell, and methods for determining a prognosis for oral cancer in a subject through the use of a compound... Agent: Mueting, Raasch & Gebhardt, P.A.

20100273183 - Diagnostic assay for anti-von willebrand factor cleaving protease (adamts13) antibodies: This invention relates to a kit to be used in an assay system for determination of an anti-von Willebrand Factor-cleaving protease (“anti-vWF-cp”) antibody in a sample. The kit comprises vWF-cp and/or vWF-fragment(s) immobilized on a solid phase. The kit can be used in a method for determination of anti-vWF-cp antibodies... Agent: Townsend And Townsend And Crew LLP

20100273179 - Method for testing or screening protein synthesis inhibitors: This invention provides methods for screening an inhibitor of protein synthesis by measuring the level of relocalization of an SMN complex component from the cytoplasm to the nucleus. Additionally, the invention provides a kit and a system for screening protein synthesis inhibitors in a cell.... Agent: Pearl Cohen Zedek Latzer, LLP

20100273177 - Methods and devices for testing saliva: Provided are methods and devices for performing sensitive, rapid antigen testing of saliva, which yield sensitivity comparable to both rapid antigen tests and saliva culture.... Agent: Foley Hoag, LLP (w/isa) Patent Group

20100273181 - Methods for the detection of glycated hemoglobin: Particular aspects of the present invention relate to methods for detecting glycated hemoglobin in, for example, human whole blood, that are not affected by the presence of variation in amino acid sequence that can exist in hemoglobin β chains. The methods detect all glycated hemoglobin in a sample, regardless of... Agent: Siemens Corporation Intellectual Property Department

20100273182 - Truncated proteins as cancer markers: Methods/reagents for detecting and/or treating cancers or potential cancers are disclosed. In one embodiment, methods and reagents for detecting truncated forms of P2X7 protein in cells are described. In one embodiment, methods and reagents for increasing the amount and/or activity of full-length P2X7 in cells are described. In one embodiment,... Agent: Medlen & Carroll, LLP

20100273185 - Detection of biased agonist activation: The invention provides single assay methods to detect the activity of biased agonists or agonists that are less than full agonists on cells.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100273184 - Device for magnetic detection of individual particles in a microfluid channel: A device dynamically detects particles of a fluid. The device can be miniaturized for detecting and selecting magnetized particles, particularly cells.... Agent: Staas & Halsey LLP

20100273191 - Methods of diagnosing cancer: A method of diagnosing cancer or a pre-malignant lesion is disclosed. The method comprises determining a level of CD24 expressed on peripheral blood cells of a subject in need thereof, wherein the level of CD24 above a predetermined threshold is indicative of the cancer or the pre-malignant lesion.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100273190 - Pkhdl1, a homolog of the autosomal recessive kidney disease gene: Nucleic acids encoding fibrocystin-L polypeptides and fibrocystin-L polypeptides are provided. Antibodies against the polypeptides, vectors and host cells containing the nucleic acids, methods for using the nucleic acids and polypeptides, and compositions and articles of manufacture also are provided.... Agent: Fish & Richardson P.C.

20100273187 - Antibodies against delta-5 desaturase and uses thereof: Disclosed are antibodies that specifically recognize Δ5-desaturase, methods of producing the antibodies, nucleotides and polypeptides for producing the antibodies, and methods of using the antibodies. The Δ5-desaturase-specific antibodies provide improved methods of detecting Δ5-desaturase in a sample.... Agent: Ross Products Division Of Abbott Laboratories Department 108140-ds/1

20100273186 - Split mutant hydrolase fusion reporter and uses thereof: The invention provides polynucleotides encoding and polypeptides corresponding to split hydrolase fusion proteins, wherein the hydrolase sequence may include at least one substitution, and use of the split hydrolase fusion proteins.... Agent: Michael Best & Friedrich LLP

20100273188 - Serum prolactin binding protein in epithelial carcinoma: The present invention relates to antibodies that have specificity towards prolactin binding protein (PRLBP) that is either bound to a binding partner or unbound to a binding partner, as well as antibodies towards PRLBP regardless of the binding state of PRLBP. The present invention also provides methods of using these... Agent: Life Technologies Corporation C/o Intellevate

20100273189 - Non separation assays with selective signal inhibitors: Methods, reagents, kits and systems are disclosed for determining an analyte in a sample, the assay method comprising forming a reaction mixture in an aqueous solution, by adding a chemiluminescent-labeled immobilized specific binding member, an activator-labeled specific binding member, a selective signal inhibiting agent, and a sample, wherein the chemiluminescent-labeled... Agent: Michael C. Schiffer - Legal Dept. Beckman Coulter, Inc.

20100273194 - Immunoreactive ehrlichia p120/p140 epitopes and uses thereof: Provided herein are immunoreactive peptides which can selectively bind Ehrlichia-specific anti-p120 or anti-p140 antibodies. Methods and kits utilizing the immunoreactive peptides are also provided. The immunoreactive peptides may be utilized, e.g., for determining whether or not a subject is infected with Ehrlichia chaffeensis or Ehrlichia canis. In certain embodiments, the... Agent: Fulbright & Jaworski, L.L.P.

20100273192 - Method for detection of disease having insulin-resistant conditions: Disclosed is a simple method for detecting a pathological condition of an insulin-resistant disease, particularly type-2 diabetes. The method comprises quantifying the ganglioside GM3 in a blood sample separated from a living body. More specifically, the method comprises the following steps (a) to (c): (a) separating a plasma or serum... Agent: Morgan Lewis & Bockius LLP

20100273193 - Triacetone triperoxide and diacetone diperoxide derivatives, method for the preparation and use thereof: wherein R1 is a hydrogen residue or an optionally halogenated or perhalogenated C1 to C5 alkyl group, R2 represents a linker molecule, and X represents a reactive or activatable group. A method for the preparation of the TATP or DADP derivatives and the use thereof as antigen for the preparation... Agent: Gregory A. Nelson Novak Druce & Quigg LLP

20100273195 - Skin aging-preventing or improving agent: The present invention provides a skin aging-preventing or improving agent. The agent contains a substance capable of enhancing the expression level of Rho kinase or myosin light-chain kinase. According to the present invention, aging of the skin such as sagging of the skin, wrinkle formation, or loss of skin elasticity... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100273196 - System and method for evaluating blood-neural barrier permeability: A system and method for evaluating blood-neural barrier permeability. Phospholipid liposomes are labeled with a fluorescent phospholipase A2 substrate and exposed to cerebrospinal fluid. The change in fluorescence is monitored to determine PLA2 activity. The PLA2 activity is used to evaluate the permeability and function of the blood-neural barrier.... Agent: Bond, Schoeneck & King, PLLC

20100273197 - Smart enzyme-containing catalytic peelable coatings: A coating material that is applied to a surface for absorbing a toxic chemical and that is removable from the surface by the use of mechanical force is disclosed. The coating material comprises one or more polymer coatings, one or more purified enzymes immobilized or entrapped in the polymer coating... Agent: Buchanan Ingersoll & Rooney PC

20100273198 - Engineering enzymatically susceptible proteins: The invention provides a synthetic phytase polypeptide which encodes an enzymatically susceptible phytase. Also provided are feed or food products comprising an enzymatically susceptible phytase, and transgenic plants which express the enzymatically susceptible phytase. Further provided are methods for making and using enzymatically susceptible phytases, e.g., a method of using... Agent: Syngenta Biotechnology, Inc. Patent Department

20100273199 - Methods and compositions: The invention relates to a method for aiding the diagnosis of a disorder in a subject, said method comprising; providing a sample from said subject wherein the sample comprises blood; assaying at least two characteristics of said sample, said characteristics selected from: the structural composition of a polypeptide comprised by... Agent: Mcandrews Held & Malloy, Ltd

20100273201 - Acetolactate synthase (als) selectable marker from trichoderma reesei: A nucleic acid encoding an acetolactate synthase (ALS) protein that provides resistance to ALS inhibitors, e.g., sulphonylurea and imidazolinone compounds, is provided. The nucleic acid may be used as a selectable marker for expression of a protein of interest in host cells.... Agent: Danisco US Inc. Attention: Legal Department

20100273202 - Codon-optimized nucleic acid for coding apo-clytin-ii and method for using the same: A codon-optimization of nucleic acid for coding apo-clytin-II protein is provided. Luminescent activity of clytin-II is remarkably enhanced. Accordingly, compared with the conventional use of the wild-type clytin-II, an intracellular calcium ion can be detected much more easily.... Agent: J C Patents

20100273206 - Diagnostic in vitro method for assessing von willebrand disease and increased bleeding risk associated with von willebrand disease and acquired or congenital disorders of platelet function: The invention relates to an in-vitro method for diagnosing Von Willebrand Disease (VWD) and an increased bleeding risk associated with Von Willebrand Disease and/or acquired or congenital platelet function defects that reduce the interactions of Von Willebrand Factor (VWF) with platelets. The in-vitro method of the invention may also be... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100273200 - In-vitro model of blood-brain barrier, in-vitro model of diseased blood-brain barrier, and drug screening method, analysis method for functions of diseased blood-brain barrier, and analysis method for pathogenesis using the same: It is intended to provide a screening system for a centrally acting drug transported across the blood-brain barrier, a drug acting on the blood-brain barrier itself, or a drug transferred into the brain without being expected to centrally act. Moreover, another object of the present invention is to achieve pathogenesis... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100273205 - Magnetic resonance imaging contrast agents: This invention relates to novel magnetic resonance imaging contrast agents, and methods of making and use thereof.... Agent: Quarles & Brady LLP

20100273203 - Methods and compositions for detecting metabolites: The present invention provides a metabolic profile, a database comprising a metabolic profile, a method for determining a metabolic profile, uses for a metabolic profile, and warfarin metabolites.... Agent: Polsinelli Shughart PC

20100273204 - Methods for monitoring the efficacy of anti-il-2r antibodies in multiple sclerosis patients: The use of HLA-DR+CD4+ T cell counts as biomarker for the efficacy of daclizumab treatment in patients diagnosed with multiple sclerosis.... Agent: Facet Biotech Corporation, Attn Legal Department

20100273207 - Methods for diagnosis of sepsis and risk of death: The present invention is directed to methods for diagnosis of sepsis and high risk of sepsis death. Such methods are directed to subjects presenting to healthcare facilities with symptoms for sepsis. Clinico-metabolomic classifiers are tested and compared in the methods of the present invention.... Agent: Ballard Spahr LLP

20100273208 - Microorganism testing apparatus: To eliminate the necessity of a dedicated optical system and the flowing of fluorescent microparticles for aligning excitation light with a flat plate-shaped flow cell which internally includes a flow path, a microorganism testing apparatus includes: a first detector that detects fluorescence emitted from microorganisms flowing through a detection flow... Agent: Antonelli, Terry, Stout & Kraus, LLP

20100273209 - Co2 optical sensor for detection and enumeration of microorganisms: A new device and method for detecting the presence of living microorganisms in test samples are described. The device includes a container having at least one section transparent to light with an incubation zone defined in the container, the incubation zone containing growth media in which the sample is cultured.... Agent: Young Basile

20100273210 - Biofuel manufacturing methods and systems incorporating radiocarbon analysis techniques: The systems and methods described herein are directed toward the use of radiocarbon analysis techniques in the manufacture of biofuel products. Among other things, methods and systems for using measured fossil-fuel-derived carbon content in biofuel products to guide the design and modification of biofuel manufacturing systems are disclosed.... Agent: Ropes & Gray LLP

20100273215 - secretion yield of a protein of interest by in vivo proteolytic processing of a multimeric precursor: The invention relates to a nucleic acid molecule encoding a multimeric precursor which after transcription is specifically cleaved in vivo to form multiple copies of a protein of interest. The invention further relates to a cell comprising this nucleic acid molecule and a method for producing a protein of interest... Agent: Morgan Lewis & Bockius LLP

20100273213 - Method for expression of specific gene: Disclosed is a cell which can express a non-natural oligomeric protein, which has, introduced therein, a gene encoding an exogenous polypeptide corresponding to at least one endogenous polypeptide constituting a natural oligomeric protein, and in which the expression of the endogenous polypeptide is inhibited.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100273214 - Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having alpha-glucuronidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes North America, Inc.

20100273212 - Pp1 ligands: The invention relates to phosphatase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate PP1 activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100273211 - Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy: Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the synaptosomal proteins, SNAP-25, VAMP, or syntaxin at discrete sites. The present invention relates... Agent: U.s. Army Medical Research And Materiel Commnad Attn: Mcmr-ja (ms. Elizabeth Arwine)

20100273216 - Methods for protein refolding: Provided herein are methods for refolding proteins. The methods involve covalently modifying a denatured protein with a nonproteinaceous polymer and then renaturing the modified protein.... Agent: Ropes & Gray LLP

20100273217 - Biocaburant preparation using pencillium funiculosum enzymes: The present invention deals with a method for treating biomass comprising the steps of providing an enzyme mixture obtained from Penicillium funiculosum deposited under Budapest treaty in the International Mycological Institute under the number IMI 378536, providing plant biomass then contacting the enzyme mixture of step (a) and the biomass... Agent: Mathews, Shepherd, Mckay, & Bruneau, P.A.

20100273218 - Compositions and method for storage of nucleic acid from bodily fluids: The present invention provides an aqueous composition comprising SDS, Cyclohexanediamine tetraacetate, Tris-HCl and proteinase K for the extraction of nucleic acid from a sample of bodily fluid, such a saliva, wherein the extracted nucleic acid is stable for at least fourteen days at room temperature The composition permits direct use... Agent: Clark & Elbing LLP

20100273220 - Innate immune suppression enables repeated delivery of long rna molecules: The present invention relates in part to methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid, to methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and... Agent: Ditthavong Mori & Steiner, P.C.

20100273219 - Multi-primer amplification method for barcoding of target nucleic acids: In certain embodiments, the present invention provides amplification methods in which nucleotide tag(s) and, optionally, a barcode nucleotide sequence are added to target nucleotide sequences. In other embodiments, the present invention provides a microfluidic device that includes a plurality of first input lines and a plurality of second input lines.... Agent: Weaver Austin Villeneuve & Sampson LLP

20100273221 - Method for producing basic substance: A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter... Agent: Cermak Nakajima LLP Acs LLC

20100273222 - Corynebacterium glutamicum enhanced expression of moaa gene encoding molybdenum cofactor biosynthesis enzyme a and method for producing l-lysine using the same: The present invention relates to a microorganism of Corynebacterium ssp. having enhanced expression of gene for encoding molybdenum cofactor biosynthesis enzyme A and a method for producing L-lysine using the same, which has effects on providing the production method of L-lysine using the Corynebacterium strain having enhanced productivity of L-lysine... Agent: Birch Stewart Kolasch & Birch

20100273223 - New calb muteins and their use: A protein having acrylation activity having a polypeptide sequence derived from SEQ ID NO: 1 or NO:2 by introducing at least one of the following amino acid substitutions: L278A, L278V, W104F, T42A, S47A.... Agent: Connolly Bove Lodge & Hutz, LLP

20100273225 - Expression cassette for lactase dehydrogenase, transformed yeast and method of producing lactic acid: A gene expressing cassette codes lactate dehydrogenase that is needed for prevention of deterioration in lactic acid yield and lactic acid production rate in continuous culture with simultaneous filtration of a yeast strain having a lactic acid-producing ability, which achieves high optical purity, high lactic acid yield and high lactic... Agent: Ip Group Of Dla Piper LLP (us)

20100273224 - Production of lactic acid by way of fermentation and extraction of amines: The invention relates to a process for the production and isolation of lactic acid which is produced by way of fermentation of a carbohydrate-bearing feedstock and the addition of ammonia. The lactic acid is released from the ammonium salt of the lactate by adding a mineral acid and the lactic... Agent: Marshall & Melhorn, LLC

20100273227 - Detoxifying pre-treated lignocellulose-containing materials: The invention relates to a process of detoxifying pre-treated lignocellulose-containing material comprising subjecting the pre-treated lignocellulose-containing material to one or more phenolic compound oxidizing enzymes.... Agent: Novozymes North America, Inc.

20100273226 - Isolated polynucleotide for increasing alcohol tolerance of host cell, vector and host cell containing the same, and method of producing alcohol using the same: Provided herein is an isolated polynucleotide for increasing the alcohol tolerance of a host cell. Also disclosed herein are a vector and a host cell containing the isolated polynucleotide, and a method of increasing the volumetric productivity of a bioalcohol using the same.... Agent: Cantor Colburn, LLP

20100273229 - Process for producing ethanol: A process for producing ethanol including a combination of biochemical and synthetic conversions results in high yield ethanol production with concurrent production of high value coproducts. An acetic acid intermediate is produced from carbohydrates, such as corn, using enzymatic milling and fermentation steps, followed by conversion of the acetic acid... Agent: Sheridan Ross PC

20100273228 - Process for producing ethanol from a hydrolysate of the hemicellulose fraction of sugarcane bagasse in a press reactor: The invention is a process for producing ethanol from sugarcane bagasse, the principal steps of which are mild sulphuric acid hydrolysis of the hemicellulose fraction of the sugarcane bagasse, followed by extraction of the hydrolysate and then fermentation thereof with the yeast Pichia stipitis. The process can be carried out... Agent: Sughrue Mion, PLLC

20100273230 - High gradient magnetic separation of biological material: The invention relates to a high gradient magnet separation device for the separation or purification of magnetic or magnetically labeled biological material, comprising a magnet, a separating column, and a ferromagnetic matrix that can be arranged in an interior chamber of the separating column, and a storage container containing a... Agent: The Nath Law Group

20100273231 - Multipotent mesenchymal stem cells from human hair follicles: The present invention is directed to an enriched preparation of multipotent mesenchymal cells obtained from human hair follicle stem cells, preferably adult human hair follicle cells. These cells can be differentiated into adipogenic, chondrogenic and osteogenic cells as well as smooth muscle cells. The present invention is also directed to... Agent: Hodgson Russ LLP The Guaranty Building

20100273232 - Methods for cloning small rna species: This invention pertains to methods for cloning microRNA (miRNA) and other small ribonucleic acid (RNA) species from relevant cell sources.... Agent: John Petravich Integrated Dna Technologies, Inc.

20100273233 - Amyloid specific peptides and uses thereof: Phage peptide display technology was used to identify peptides that bind specifically to the amyloid form of the Aβ1-40 peptide. Peptides with similar structural features and bind to the amyloid form of Aβ1-40 but not to monomeric Aβ1-40, are provided. Such peptides are useful as carrier molecules to deliver therapeutic... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100273234 - Process for obtaining bioactive recombinant protein from inclusion bodies: This invention provides a process for obtaining bioactive recombinant protein from inclusion bodies without unfolding it completely into random coil structure. The process comprises solubilization of inclusion body protein using urea and propanol.... Agent: Schwegman, Lundberg & Woessner, P.A.

20100273235 - Stabilized aqueous alpha-galactosidase composition and methods relating thereto: The present invention provides an aqueous composition comprising a protein with enzymatic activity of alpha-galactosidase. The present invention further provides a method of stabilizing an aqueous composition comprising a protein with enzymatic activity of alpha-galactosidase, and a method of preparing a purified aqueous composition comprising the protein with enzymatic activity... Agent: Roche Diagnostics Operations Inc.

20100273236 - Recombinant host for producing l-asparaginase ii: The invention provides a recombinant Escherichia coli host cell for producing an Escherichia coli L-asparaginase II enzyme. The host cell includes an Escherichia coli chromosome and at least one copy of a recombinant extrachromosomal vector, wherein the recombinant extrachromosomal vector encodes the L-asparaginase II enzyme, wherein the host cell chromosome... Agent: Lucas & Mercanti, LLP

20100273237 - Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages: The invention provides processes for the producing compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle. The invention further provides processes for producing nucleotide compositions comprising oligonucleotides suitable... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100273238 - Cellular permissivity factor for viruses and uses thereof: The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus.... Agent: Wyeth LLC Patent Law Group

20100273240 - Method for production and purification of macromolecular complexes: The present invention relates to a method for production and purification of affinity tagged macromolecular complexes, such as ribosomes. More closely, the method comprises in-frame fusion of a nucleotide sequence specific for an affinity tag and a selection marker, wherein the fusion is at the chromosomal site of a gene... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100273239 - Lactobacillus helveticus bacterium composition for treatment of atopic dermatitis: A Lactobacillus helveticus bacterium composition for treatment of atopic dermatitis in a human.... Agent: Foley And Lardner LLP Suite 500

20100273241 - Method for manufacturing red mold dioscorea: The present invention discloses a method for manufacturing red mold dioscorea, and the method comprises the following steps: adding some water with an appropriate ratio to fresh dioscorea or dried dioscorea; sterilizing the dioscorea; after the dioscorea being cooled down, inoculating the dioscorea with Monascus species; cultivating the dioscorea with... Agent: Roger H. Chu

20100273242 - Biological desulfurization apparatus: Disclosed is a desulfurization apparatus including a biological reaction tank 1 into which a hydrogen sulfide gas-containing gas is introduced, a carrier-packed layer 2a, 2b that is arranged in the biological reaction tank 1 and packed with a carrier for adhesion of microorganisms, a means that feeds an oxygen-containing gas... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100273243 - Nozzle device and liquid sample analyzer: (T) and that sucks a liquid in the closed container (T), an exposure to atmosphere mechanism (3) that opens the closed container (T) to the atmospheric air, and an opening/closing structure (4) that is arranged at a proximal end of the nozzle (2) and that has an internal flow channel... Agent: Snell & Wilmer LLP (oc)

20100273244 - Apparatus for performing counts within a biologic fluid sample: An apparatus for enumerating one or more specific elements within a biologic fluid sample is provided. The apparatus includes a first planar member that is transparent, and a second planar member. The members are separated from one another by a substantially uniform height, and the height is sized relative to... Agent: O''shea Getz P.C.

20100273245 - Reaction vessel, reaction vessel liquid introducing device, liquid introducing and reaction measuring device, and liquid introducing device: The invention relates to a reaction vessel, a reaction vessel liquid introducing device, a liquid introducing and reaction measuring device, and a liquid introducing device, and is directed to being able to perform temperature control of a liquid stored within the reaction vessel with a high accuracy and faithful responsiveness.... Agent: Haynes And Boone, LLPIPSection

20100273246 - Whole smoke exposure apparatus: An apparatus includes a smoke emitting section which emits smoke containing particulate matter, a dilution section for diluting the smoke emitted by the smoke emitting section, a clean air unit which supplies clean air to the dilution section, at least one chamber which incorporates a cell-adhered surface and into which... Agent: Birch Stewart Kolasch & Birch

20100273247 - Semi-quantitative immunological detection device with differential antibodies or substrates: A semi-quantitative immunological detection device with differential antibodies and substrates is provided. The semi-quantitative immunological detection device with differential antibodies, includes: a sample injecting portion through which a sample is injected; and a reaction portion where a plurality of reacting materials reacting with an MUT (material under test) contained in... Agent: Ampacc Law Group

20100273248 - Solution bag for apparatus for chemically analyzing blood: The present invention provides a solution bag that is used for medical treatment and stores solution used for an apparatus for analyzing blood chemistry that measures and analyzes the concentrations of electrolytes, the partial pressures of gases, and the concentrations of metabolites or the volume ratio of red blood cells... Agent: Rabin & Berdo, PC

20100273249 - Analytical test strips: An analytical test strip includes a substrate and a reagent layer disposed on a portion of the substrate. The reagent layer includes an enzymatic reagent ink comprising an amount of hydrophobic silica material, an amount of surfactant; and an amount of enzyme. The amounts of the hydrophobic silica material and... Agent: Philip S. Johnson Johnson & Johnson

20100273250 - Reaction vessel, reaction vessel liquid introducing device, liquid introducing and reaction measuring device, and liquid introducing device: The invention relates to a reaction vessel, a reaction vessel liquid introducing device, a liquid introducing and reaction measuring device, and a liquid introducing device, and is directed to being able to perform temperature control of a liquid stored within the reaction vessel with a high accuracy and faithful responsiveness.... Agent: Haynes And Boone, LLPIPSection

20100273251 - Multiple tray vermicomposter with thermal siphon airflow: The invention is a vermicomposter which is a composting device that uses earthworms or worms to accelerate the composting process. A multiple tray system is used to greatly increase compost production and for convenience of compost harvesting. The invention uses thermal siphon airflow and light-tight air permeable connections between its... Agent: Craig A. Simmermon

20100273252 - Algae cultivation apparatus: An algae cultivation apparatus includes a light guide plate, at least one transparent circulating channel, at least one light emission module, an algae guide-in module, an algae collection module, a gas guide-in module, a gas collection module, a culture medium guide-in module, a temperature control module and a pH value... Agent: Schmeiser, Olsen & Watts

20100273253 - Dynamic systems for culturing cells in 3d supports: The present invention refers to the conception process of new dynamic systems for cell culture in 3D supports appropriate to its growing. These are constituted by:—cylindrical container (1) exhibiting a terminal area with a truncated inverted cone shape (2) in the lower internal zone;—cylindrical screw lid (4) the upper external... Agent: Patent Docket Clerk Cowan, Liebowitz & Latman, P.C.

20100273254 - Process for purification of plasmid dna: The invention relates to a process for purifying plasmid DNA. The invention also relates to a DNA product made by the process of the invention. The DNA product is suitable for pharmaceutical use.... Agent: Sughrue Mion, PLLC

20100273255 - Human micrornas and methods for inhibiting same: The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a microRNA shown in SEQ ID NOs: 1-94; 281-374; 467-481; 497-522; or 549, except that up to thirty percent of the bases may be wobble bases, and up to 10% of... Agent: Hoffmann & Baron, LLP

20100273256 - Human potassium channel genes: Methods for isolating K+Hnov genes are provided. The K+Hnov nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the... Agent: Annette S. Parent, Esq. Townsend And Townsend And Crew LLP

20100273257 - Apo-2dcr: Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.... Agent: Genentech, Inc.

20100273258 - Interactive microenvironment system: A culture cell for growing animal cells in vitro has sides and a bottom forming a volume. The volume contains a layer of nanofiber upon which animal cells can be cultured. The layer of nanofiber can be oriented or non-oriented. Multiple layers can be placed in the volume, where the... Agent: Mueller And Smith, Lpa Mueller-smith Building

20100273259 - Substrates and methods for culturing stem cells: The present disclosure provides a device and a cell culture system comprising a substrate that generates significant chemical ion signatures adapted for culturing stem cells. This disclosure further provides unique surface properties, such as surface wettability, along with defined polymer microspot environments in an array, for effectively supporting the propagation... Agent: Sutherland Asbill & Brennan LLP

20100273260 - Cell culture substrate and process for producing the same and method for culturing cells: The present invention relates to a cell culture substrate in which a polymer chain having a hydrophilic skeleton is grafted onto a surface of polystyrene or poly(ε-caprolactone) having a water contact angle of from 75° to 100°. This cell culture substrate has excellent efficiency of cell culture without the necessity... Agent: Sughrue-265550

20100273261 - Methods for producing synthetic surfaces that mimic collagen coated surfaces for cell cultue: The present invention discloses methods for producing synthetic surfaces that mimic collagen coated surfaces for cell culture comprising: providing a monomer source comprising one or more organic compounds which are capable of polymerization, wherein at least one organic compound is prolinol; creating a plasma of said monomer source; and contacting... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100273262 - Apparatuses and methods for gel molding and culture: A gel molding apparatus is adapted to be used in combination with a vessel that has a plurality of solution chambers, and includes a lid plate and a plurality of columns that project from a top surface of the lid plate. Each of the columns has a bottom side connected... Agent: Townsend And Townsend And Crew, LLP

20100273263 - Cell culture vessel and method of production thereof: Disclosed is a method of producing a cell culture vessel (10) having a carbon nanotube (CNT) layer (14) on its surface. The method comprises the steps of providing a vessel (12) having a predetermined shape; providing a CNT dispersion of a CNT material composed primarily of CNT dispersed in a... Agent: J-tek Law PLLC

20100273264 - Apparatus for and method of preparing plant tissue for plant production: An apparatus for preparing plant tissue (e.g., somatic embryos, embryogenic tissue, organogenic tissue, vegetative tissue, seeds, etc.) for plant production includes a first station having a first rack system configured to support at least one culture vessel, a second station having an automated member configured to manipulate the at least... Agent: Foley And Lardner LLP Suite 500

20100273265 - Regeneration and neogenesis of retinal photoreceptor cell using otx2 gene: The present invention provides a medicine, comprising (a) an Otx2 protein or its partial peptide, or a salt thereof, or (b) a DNA or an RNA encoding an Otx2 protein or its partial peptide. The present medicine is useful as an agent for preventing, treating or suppressing progression of a... Agent: Wenderoth, Lind & Ponack, L.L.P.

  
10/21/2010 > patent applications in patent subcategories. categorized by USPTO classification

20100267002 - Peptide having life-lengthening effect on cells: This invention provides a substance that exhibits excellent life-lengthening effects on cells, that is excellent in terms of productivity, and that has low immunological toxicity. The present invention relates to a preservative for a biomaterial comprising (a) a peptide consisting of the amino acid sequence as shown in SEQ ID... Agent: Sughrue Mion, PLLC

20100267004 - Method, substances and kits for labeling population of rna and other substances containing vicinal diols: A method for labeling biological molecules and synthetic molecules that contain a geminal diol, such as RNA, carbohydrates or glycoproteins, using a periodate sequestering agent is provided. Compositions and kits for use in the labeling method are also provided.... Agent: Sheldon Mak & Anderson PC

20100267003 - Methods and kit for endometriosis screening: Methods of screening a bodily sample for endometriosis are provided. The bodily sample is preferably saliva. According to one embodied method, the bodily sample is subjected to a denaturing procedure, and a property of the bodily sample observed after the denaturing procedure is evaluated for the presence or absence of... Agent: Berenato & White, LLC

20100267008 - Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups: This invention relates to the functionalized cyanine dyes and more particularly, to the synthesis of chiral 3-substituted 2,3′-dimethyl-3H-indole and its derivatives as intermediates for preparation of cyanine dyes, to methods of preparing these dyes and the dyes so prepared.... Agent: Nixon & Vanderhye, PC

20100267005 - Crosslinking within coordination complexes: Crosslinked proteins, proteins and polymers, and polymers and methods of making the same are disclosed. In one illustrative embodiment, a method is provided comprising the steps of attaching a chelator to one or more polymers; creating a coordination complex between the first protein, the second protein, and a metal ion;... Agent: Thorpe North & Western, LLP.

20100267010 - Method and apparatus for real-time analysis of chemical, biological and explosive substances in the air: A device for real-time analysis of airborne chemical, biological and explosive substances has at least a gas analysis sensor, fluorescence/luminescence sensor and a sensor for determining the particle size and number of particles. Each of the sensors is connected to a multireflection cell (multipass laser cell) as an open measurement... Agent: Crowell & Moring LLP Intellectual Property Group

20100267006 - Method for detection of cirulent strain of influenza type-a virus: The present invention provides a method for detecting a virulent strain of influenza virus in a specific, rapid and simple manner, and an assay device therefor. A method for detecting a virulent strain of influenza A virus is provided, which comprises providing a first antibody that is reactive with all... Agent: Fitch, Even, Tabin & Flannery

20100267009 - Method for the in vitro diagnosis and/or in vitro therapy monitoring of infections: A method for in-vitro diagnosis and/or in-vitro therapy monitoring of infections and/or infectious diseases and differentiation between acute infections and latent or overcome infections comprising incubating eukaryotic cells with an antigen; and testing for cells (ASCs) secreting antigen-specific antibodies, the secreted antibodies of which are directed specifically against the antigen.... Agent: Ip Group Of Dla Piper LLP (us)

20100267007 - Solid-fluid composition and uses thereof: A nanostructure comprising a core material of a nanometric size surrounded by an envelope of ordered fluid molecules is disclosed. The core material and the envelope of ordered fluid molecules are in a steady physical state. Also disclosed, a liquid composition comprising liquid and the nanostructure.... Agent: Foley And Lardner LLP Suite 500

20100267042 - Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance: The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to... Agent: Kilpatrick Stockton LLP

20100267045 - Cudr as biomarker for cancer progression and therapeutic response: Disclosed is a novel human gene designated CUDR. Provides is also a CUDR gene as a biomarker in the diagnosis of human cancers and a cancer therapy.... Agent: Knobbe Martens Olson & Bear LLP

20100267020 - Genetic risk factor for neurodegenerative disease: The present invention relates to single base polymorphisms in the glycogen synthase kinase 3 beta and risk for developing neurodegenerative disease.... Agent: Townsend And Townsend And Crew, LLP

20100267044 - Genetically engineered biological indicator: The disclosed technology relates to a genetically engineered biological indicator, comprising: at least one test organism and at least one reporter gene suitable for producing an indicator enzyme, the reporter gene being taken up by the test organism; and at least one repressor gene that inhibits expression of the reporter... Agent: Renner Otto Boisselle & Sklar, LLP

20100267037 - Genotoxicity as a biomarker for inflammation: The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease... Agent: Karen S. Canady Canady & Lortz LLP

20100267027 - Her-2 binding antagonists: There is disclosed a a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO:1, wherein the polypeptide binds to the extracellular... Agent: Davis Wright Tremaine, LLP/seattle

20100267012 - Highly conserved genes and their use to generate probes and primers for detection of microorganisms: Compositions and methods for the detection of vancomycin-resistant pathogens using primers and/or probes to the vanA and vanB genes.... Agent: Knobbe Martens Olson & Bear LLP

20100267019 - Identification and use of genes encoding amatoxin and phallotoxin: The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptide toxins and toxin production in mushrooms. In particular, the present invention relates to using genes and proteins from Amanita species encoding Amanita peptides, specifically relating to amatoxins and phallotoxins. In a preferred embodiment, the... Agent: Medlen & Carroll, LLP

20100267034 - Markers for prenatal diagnosis and monitoring: Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more RNA species derived from a... Agent: Townsend And Townsend And Crew, LLP

20100267011 - Method and apparatus for detecting nucleic acids using bead and nanopore: There are provided a method and apparatus for detecting nucleic acid using bead and nanopore, and more specifically, a method and apparatus capable of detecting nucleic acid fragments of 70 bps to 300 bps in length by a nanopore detection unit with nanopores of 20 to 120 nm in diameter... Agent: Cantor Colburn, LLP

20100267014 - Method for prognosis of a response to a treatment: The present invention concerns an in vitro method for determining, from a biological sample, the response to a patient suffering from rheumatoid arthritis to a treatment directed against a cytokine involved in the inflammatory process of the disease, characterized in that it consists in measuring the expression of the gene... Agent: Oliff & Berridge, PLC

20100267039 - Method of differentiating coccidioides species: The invention pertains to methods and kits useful in the identification of and differentiation between Coccidioides immitis and Coccidioides posadasii. The methods involve the addition of oligonucleotides to mixtures containing nucleic acid isolated from a sample and performing nucleic acid amplification on the mixture.... Agent: The Translational Genomics Research Institute

20100267029 - Method of identifying the plant species of the genus uncaria: The present invention provides a method of identifying the plant species of the genus Uncaria with high accuracy. The present invention relates to a method of identifying the plant species of the genus Uncaria contained in a test sample, comprising comparing the nucleotide sequence of the ITS region of ribosomal... Agent: Lucas & Mercanti, LLP

20100267031 - Method of screening for rage-amyloid-beta peptide interaction inhibiting materials: Provided are a system and a method of screening for RAGE-amyloid beta peptide interaction inhibiting materials using a Transwell plate and a RAGE-expressing cell line.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100267021 - Methods for determining cytosine methylation in dna and uses thereof: Methods are described for determining the pattern of cytosine methylation in a DNA specimen, where the methods involve comparing the amount of DNA fragments generated by a methylation-sensitive restriction enzyme with the amount of DNA fragments generated by a methylation-insensitive isoschizomer of the methylation-sensitive restriction enzyme.... Agent: Amster, Rothstein & Ebenstein LLP

20100267026 - Methods and apparatus for characterizing polynucleotides: Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase, adjacent the nanopore aperture.... Agent: Clark & Elbing LLP

20100267033 - Methods and compositions for detecting autoimmune disorders: The invention provides methods and compositions useful for detecting autoimmune disorders.... Agent: Genentech, Inc.

20100267025 - Methods and compositions for the assessment of cardiovascular function and disorders: The present invention provides methods for the assessment of risk of developing acute coronary syndrome (ACS) in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing ACS. Nucleotide probes and primers, kits, and... Agent: Davis Wright Tremaine LLP - San Francisco

20100267035 - Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents: The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening... Agent: Jones Day

20100267013 - Methods to increase nucleotide signals by raman scattering: The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid. In other embodiments, unlabeled nucleic acids are used. Exonuclease treatment of the nucleic acid results in the... Agent: Pillsbury Winthrop Shaw Pittman LLP (intel)

20100267040 - Mn/ca ix and cancer prognosis: Herein disclosed are methods that are prognostic for neoplastic/preneoplastic disease in a subject vertebrate, wherein said disease is associated with a tissue that normally expresses MN, but which MN expression is lost or diminished upon carcinogenesis. Exemplary of the types of preneoplastic/neoplastic diseases subject to the prognostic methods of this... Agent: Leona L. Lauder

20100267017 - Monitoring real-time pcr with label free intrinsic imaging: The invention provides a method for the detection of nucleic acid the method comprising carrying out a PCR reaction in a microfluidic device wherein the sample shuttles within the microfluidic channel and the amount of nucleic acid is determined based on the UV absorption of the nucleic acid.... Agent: Lando & Anastasi, LLP

20100267022 - Monocyte-derived nucleic acids and related compositions and methods: Nucleic acids encoding various monocyte-derived proteins and related compositions, including purified proteins and specific antibodies are described. Methods of using such composition are also provided.... Agent: Merck C/o Dnax

20100267024 - Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease: The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain... Agent: Myers Bigel Sibley & Sajovec

20100267015 - Nucleic acid detection: The invention provides methods for the detection of the amount of a nucleic acid in a sample. The described methods exploit the ability to disrupt and redirect a PCR direction, and the ability to physically pair nucleic acid molecules in a sample that have a reference sequence with nucleic acid... Agent: Howrey LLP-ca

20100267018 - Oligonucleotide analogues: The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked Nucleoside Analogues), are able to provide valuable improvements to oligonucleotides with respect to affinity and specificity towards complementary RNA and DNA oligomers. The novel... Agent: Edwards Angell Palmer & Dodge LLP

20100267036 - Polymorphism identification method: The present invention is to provide a method for identifying a polymorphism. The method includes performing a nucleic acid chain extension reaction and identifying the polymorphism of the nucleic acid contained in the test nucleic acid sample. The extension reaction is conducted with use of a nucleic acid in a... Agent: Scully Scott Murphy & Presser, PC

20100267038 - Polynucleotides for the amplification and detection of chlamydia trachomatis and neisseria gonorrhoeae: Polynucleotides useful for detecting Chlamydia trachomatis and/or Neisseria gonorrhoeae in a test sample, kits, a nucleic acid amplification method and detection method including the same.... Agent: Abbott Laboratories C/o Polsinelli Shughart PC

20100267032 - Prediction of likelihood of cancer recurrence: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.... Agent: Genomic Health, Inc. (bozicevic, Field & Francis) C/o Kathleen Determann

20100267023 - Selective restriction fragment amplification: fingerprinting: The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. Application of this process to human, animal... Agent: Foley And Lardner LLP Suite 500

20100267041 - Serial analysis of biomarkers for disease diagnosis: The present invention generally relates to serial analysis of biomarkers for disease diagnosis. In certain embodiments, the invention provides methods for diagnosing a disease including obtaining a sample from a subject, conducting a first assay to determine whether a first biomarker in the sample is positive or negative for a... Agent: Brown Rudnick LLP

20100267043 - System and method for identification of individual samples from a multiplex mixture: An embodiment of an identifier element for identifying an origin of a template nucleic acid molecule is described that comprises a nucleic acid element comprising a sequence composition that enables detection of an introduced error in sequence data generated from the nucleic acid element and correction of the introduced error,... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris,

20100267030 - Systems and methods for measuring translation activity in viable cells: Systems for measuring protein translation and methods for measuring overall translation activity in viable cells or subcellular compartments is disclosed. The methods identify general ribosomal activity, if desired at sub-cellular resolution, thereby providing a signal indicating the rate of any of the steps of protein synthesis selected from initiation, elongation,... Agent: Winston & Strawn LLP Patent Department

20100267028 - Tgfbr1 haploinsufficiency modifies risk for cancer: The present invention provides methods for assessing a genetic susceptibility to cancer in a subject which includes measuring allele specific expression or presence of at-risk haplotypes of TGFBR1, where a difference in expression or the presence of at-risk haplotypes is indicative of a cancer or susceptibility to a cancer. Methods... Agent: Swanson & Bratschun, L.L.C.

20100267016 - Transgenic microbial polyhydroxyalkanoate producers: Transgenic microbial strains are provided which contain the genes required for PHA formation integrated on the chromosome. The strains are advantageous in PHA production processes, because (1) no plasmids need to be maintained, generally obviating the required use of antibiotics or other stabilizing pressures, and (2) no plasmid loss occurs,... Agent: Pabst Patent Group LLP

20100267053 - Akt3 polypeptides: The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein.... Agent: Merck Patent Department (k-6-1, 1990)

20100267051 - Annexin for cancer risk assessment: A method treats urogenital and/or intestinal tract cancer and includes administering a therapeutically effective amount of at least one annexion protein, annexin of A3, to a mammal.... Agent: Ip Group Of Dla Piper LLP (us)

20100267052 - Compositions and methods for diagnosis and treatment of type 2 diabetes: The present invention relates generally to the identification of biological markers associated with an increased risk of developing Diabetes, as well as methods of using such biological markers in diagnosis and prognosis of Diabetes. The biological markers of the invention may indicate new targets for therapy or constitute new therapeutics... Agent: David S. Resnick

20100267049 - Diagnostic devices and related methods: Devices, systems, and methods for detecting the presence of one or more analytes in a sample are described. In some variations, a test strip may be used to detect and/or analyze one or more analytes in a sample. In certain variations, a test strip configured to receive a sample for... Agent: Morrison & Foerster LLP

20100267046 - Isoform-selective inhibitor and activators of pde3 cyclic nucleotide phosphodiesterases: The present invention concerns methods and compositions related to type 3 phosphodiesterases (PDE3). Certain embodiments concern isolated peptides corresponding to various PDE3A isoforms and/or site-specific mutants of PDE3A isoforms, along with expression vectors encoding such isoforms or mutants. In specific embodiments, methods for identifying isoform-selective inhibitors or activators of PDE3... Agent: Ballard Spahr LLP

20100267048 - Method for measurement of hemoglobin and hemoglobin derivative, and measurement kit: Hemoglobin in a sample solution is quickly and reliably denatured; at the same time, quick and accurate measurement of hemoglobin and a hemoglobin derivative is realized. In a method for measuring hemoglobin and a hemoglobin derivative, and a reagent composition, a measurement kit, an analysis device, and an analysis system... Agent: Hamre, Schumann, Mueller & Larson P.C.

20100267050 - Methods and compositions for targeting polyubiquitin: Anti-polyubiquitin monoclonal antibodies, and methods for using the antibodies, are provided.... Agent: Genentech, Inc.

20100267047 - Test method on feline vaccinated with feline immunodeficiency virus vaccine, and antigen for use in the test: Since FIV-vaccinated cats produce antibodies against FIV, distinguishing them from FIV-infected cats is difficult by serological diagnostic methods using FIV and FIV-derived substances. The present invention enables tests for determining the presence or absence of a FIV vaccination history in a cat by detecting antibodies that are produced as a... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100267057 - Cell surface display, screening and production of proteins of interest: Aspects of the invention provide compositions and methods for displaying engineered polypeptides on a cell surface. According to aspects of the invention, immobilized polypeptides can be screened to identify one or more variants having one or more functional or structural properties of interest. Aspects of the invention provide composition and... Agent: Proskauer Rose LLP

20100267058 - Circulating ret receptor: Provided are compositions, methods, and kits relating to the detection of a circulating or soluble form of the KET receptor tyrosine kinase.... Agent: Siemens Corporation Intellectual Property Department

20100267059 - Immunodeficiency screening at point of care: Embodiments of the invention utilizes advanced detection methodologies as a cost-effective, efficient, ultra-sensitive rapid method for diagnosing severe combined immunodeficiency (SCID) in infants. In certain aspects, multiple markers of SCID are concurrently detected and measured to provide a more efficient, sensitive and accurate diagnosis of SCID.... Agent: Fulbright & Jaworski L.L.P.

20100267054 - Measuring the activity of proteases: A method and apparatuses for determining the total content of proteases by means of measuring their enzyme activity after previous deinhibition is disclosed. In biological samples, lysosomal proteases are completely (e.g. in blood serum) or partly (e.g. in tissue homogenates) inhibited. A method proposed for the deinhibition entails immersing a... Agent: Fitch Even Tabin & Flannery

20100267056 - Differential labelling method: The invention relates to a method for differentially labelling one or more entities, together comprising distinct reactive sites. The invention further relates to an entity that has been labelled by a method according to the invention and to a diagnostic kit comprising a labelled entity and to a diagnostic kit... Agent: Hoffmann & Baron, LLP

20100267055 - One-step immunoassays exhibiting increased sensitivity and specificity: The present disclosure relates to immunoassays for detecting or quantifying at least one analyte of interest in a test sample which exhibits improved sensitivity or sensitivity and specificity compared to the immunoassay formats known in the art.... Agent: Paul D. Yasger Abbott Laboratories

20100267061 - Detecting phospholipidosis and diagnosing lysosomal storage disorders: Disclosed are methods for evaluating the potential or activity of a test compound to induce phospholipidosis in a target subject, for managing patient treatment, and for diagnosing a lysosomal storage disorder in a human subject.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100267060 - High sensitivity secretagogin assays and their uses for diagnosis and/or prognosis: The present invention relates to methods and compositions for measuring secretagogin in test samples, particularly patient samples. Preferred methods comprise performing a sandwich immunoassay, most preferably using a pair of monoclonal antibodies that bind to secretagogin.... Agent: Inverness Medical Innovations / Wsgr Wilson Sonsini Goodrich & Rosati, P.C.

20100267062 - Osteopontin as novel prognostic biomarker for heart failure: The present invention relates to methods for providing a diagnosis, prognosis and/or risk stratification of a subject with heart failure, comprising determining the concentration of osteopontin (OPN) in the biological sample, preferably in a plasma sample. An OPN cut-off value is discloses as a valuable reference value. The present invention... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100267063 - Methods and apparatuses for conducting assays: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration... Agent: Wolf Greenfield & Sacks, P.C.

20100267064 - Methods for quantitative target detection and related devices and systems: Described herein is a method for detection of a target in a sample and related devices and systems.... Agent: Steinfl & Bruno

20100267065 - Apparatus and methods for analyzing fluid variables: Methods and devices for analyzing fluid variables such as viscosity, surface tension, analyte concentration, the presence of particulates or aggregates are provided. The devices analyze fluid variables by measuring cessation of fluid flow through the medium or a change in flow rate due to an inherent property of the fluid... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100267066 - Microchip and blood monitoring device: A microchip comprising therein a first channel which allows inflow of a first liquid selected from whole blood, platelet-rich plasma and a drug-treated liquid thereof, a second channel connected to the first channel, which allows inflow of a second liquid containing an agent that is reactive with the first liquid,... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20100267067 - Synthase inhibitor screening method: The present invention relates to a method for selecting at least one host cell secreting one or more active enzyme of interest, said method comprising the steps of: a) providing a growth medium comprising one or more synthase inhibitor, which inhibits the synthesis of at least one essential compound in... Agent: Novozymes North America, Inc.

20100267068 - Analysis of doping compounds: Process for determination of a drug or medicament or their metabolites in a (body) fluid or an extract of (body) tissue or (body) sample comprising the steps: (i) optionally treatment of the fluid or sample extract with at least one enzyme, (ii) contacting at least a first part of the... Agent: Nixon & Vanderhye, PC

20100267069 - Analysis of proteins from biological fluids using mass spectrometric immunoassay: Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins present in complex biological fluids or extracts. Pipettor tips containing porous solid supports that are covalently derivatized with affinity ligand and used to extract specific proteins and their variants from various biological fluids. Nonspecifically bound... Agent: Zeman-mullen Law Firm PLLC

20100267070 - Pharmaceutical compositions for the treament of conditions responsive to proteasome inhibition: The invention disclosed herein generally relates to methods and compositions for inhibiting proteasome activity comprising a syrbactin compound have the structure of Formula (I) or (II).... Agent: Davis Wright Tremaine LLP - San Francisco

20100267071 - Solution phase homogeneous assays: Methods, reagents, kits and systems are disclosed for determining an analyte in a sample suspected of containing the analyte where all reagents are soluble in aqueous solution. One assay method includes treating a sample suspected of containing the analyte under conditions such that if the analyte is present, an activator... Agent: Michael C. Schiffer - Legal Dept. Beckman Coulter, Inc.

20100267077 - method of measuring the ability of a sample to withstand reactive oxygen species (ross): A method of measuring the ability of a biological sample to withstand reactive oxygen species (ROSs). The method includes at least the steps of putting the sample for testing and a photosensitive agent in a liquid medium into contact so as to form a mixture for testing, subjecting the mixture... Agent: Young & Thompson

20100267072 - Formation/elongation of axon by inhibiting the expression or function of singar and application to nerve regeneration: Singar is identified as a novel molecule, whose expression is varied before and after the polarization of a nerve cell, and occurs in the tip of an elongating axon, called a growth cone, which is important for the formation or elongation of an axon. Singar is expressed specifically in the... Agent: Fitch, Even, Tabin & Flannery

20100267079 - Identification and isolation of transitional cell carcinoma stem cells: Transitional cell carcinoma stem cells (TCCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and in cancer diagnosis.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20100267074 - Measurement and uses of oxidative stress: The present invention provides a method of determining the overall oxidative status of a body fluid or a tissue of a patient by measuring the oxidation-reduction potential (ORP) of the body fluid or tissue. The method has been found to be useful in the diagnosis, evaluation and monitoring of patients... Agent: Sheridan Ross PC

20100267075 - Microfluidic lysis: The invention provides methods for isolating and identifying nucleated cells from biological samples using a microfluidic device.... Agent: Viksnins Harris & Padys Pllp

20100267078 - Selective detection of proteins that contain two or more alpha-helical transmembrane domains: Embodiments of the present invention provide a staining solution and of method of using the staining solution for selectively detecting proteins that contain two or more α-helical transmembrane domains. The staining solution comprises a lipophilic dyes and at least about a 30% hydrophobic solvent. The dyes of the present are... Agent: Life Technologies Corporation C/o Intellevate

20100267076 - Separation of co-cultivated cell populations: The invention relates to a method and the use of an apparatus for separating co-cultivated cell populations.... Agent: Wood, Phillips, Katz, Clark & Mortimer

20100267073 - Stem cell-based culture system for drug development: The present invention relates to culture systems comprising differentiated stem cells, that may be used for identifying agents useful in treating degenerative nervous system disorders and are suitable for high-throughput screening applications. It is based, at least in part, on the discovery that co-cultures of (i) astrocytes expressing a mutated... Agent: Cooper & Dunham, LLP

20100267080 - Reagent for blood analysis and method of use thereof: The present disclosure provides a reagent for blood analysis which may include: (1) a compound having the general formula I as a fluorescent dye, wherein n, X, R1, R2, R3, R4, R5 and Y− are as defined in the specification; (2) a surfactant selected from cationic surfactants, zwitterionic surfactants and... Agent: Mindray C/o Stoel Rives LLP

20100267081 - Method and device for fixing/stabilising a sample: The present invention provides a method for fixing and/or stabilizing a sample, in which the sample is put into a permeable container with a maximum overall height of 10 mm, preferably of 5 mm, and the container filled with the sample is immersed in fixing and/or stabilizing agents and the... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100267082 - Novel peptide-forming enzyme gene: DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a dipeptide includes producing a dipeptide from a carboxy component and an amine component by using a culture of a microbe... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100267088 - Inha promoters: The present invention relates to an isolated DNA sequence having promoter activity and to vectors comprising the DNA sequence. The promoters of the invention are referred to inhA promoters. The invention also relates to a method of producing a protein in a recombinant host cell wherein the host cell comprises... Agent: Codexis, Inc.

20100267083 - Modified cytochrome p450 monooxygenases: The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.... Agent: Novak Druce Deluca + Quigg LLP

20100267087 - Mutant pyrrolysyl-trna synthetase, and method for production of protein having non-natural amino acid integrated therein by using the same: Method for incorporating a lysine derivative (particularly an Nε-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional group, fluorescent group or crosslinker, which is suitable as a non-natural amino acid, into a desired protein in a site-specific manner. A mutant pyrrolysyl-tRNA synthetase has substitution of... Agent: Birch Stewart Kolasch & Birch

20100267085 - Novel pseudochlorococcum species and uses therefor: The present invention relates to algal species and compositions, methods for identifying algae that produce high lipid content and possess CO2 tolerance, and methods for using such algae for lipid isolation, wastewater remediation, waste gas remediation, and/or biomass production.... Agent: Davis Wright Tremaine LLP - San Francisco

20100267086 - Optimized nucleic acid sequences for the expression of vb4-845: An optimized nucleic acid sequence encoding the immunoconjugate VB4-845 is disclosed. Modifications to the original VB4-845 nucleic acid sequence include optimization of the sequences encoding the VH region, VL region, linkers and pseudomonas exotoxin A. The modifications improved the yield of VB4-845 in an Escherichia coli expression system... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20100267084 - Protein glycosylation modification in methylotrophic yeast: The present invention provides genetically engineered strains of Pichia capable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present invention are capable of expressing either or both of an α-1,2-mannosidase and glucosidase II. The genetically engineered strains of the present invention can be further... Agent: Scully Scott Murphy & Presser, PC

20100267089 - Endoglucanases: The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.... Agent: Townsend And Townsend And Crew LLP/codexis, Inc.

20100267090 - Novel saccharide primer: The present invention discloses a saccharide primer for synthesizing, in culture cells, an O-glycan sugar chain having the structure of sugar chain-amino acid-alkyl group or alkyl group derivative.... Agent: Tarolli, Sundheim, Covell & Tummino L.L.P.

20100267092 - Components: A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is... Agent: Merchant & Gould PC

20100267091 - Method for a continuous rapid thermal cycle system: Disclosed herein is an efficient, high speed production scale synthesis method for high molecular weight organic substances, such as DNA. The invention includes a method of conducting a polymerase chain reaction which comprises transporting a liquid through polymeric tubing disposed through a first reaction cycle region and at least a... Agent: The Law Office 0f Geoffrey M. Karny

20100267093 - Enhanced homologous recombination mediated by lambda recombination proteins: Disclosed herein are methods for generating recombinant DNA molecules in cells using homologous recombination mediated by recombinases and similar proteins. The methods promote high efficiency homologous recombination in bacterial cells, and in eukaryotic cells such as mammalian cells. The methods are useful for cloning, the generation of transgenic and knockout... Agent: Klarquist Sparkman, LLP (ott-nih)

20100267094 - Use of phosphoketolase for producing useful metabolites: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention... Agent: Cermak Nakajima LLP Acs LLC

20100267095 - Escherichia coli strains which over-produce l-threonine and processes for the production of l-threonine by fermentation: The present invention relates to the fields of microbiology and microbial genetics. More specifically, the invention relates to novel bacteria strains and processes employing these strains for the fermentative production of amino acids such as threonine.... Agent: Buchanan Ingersoll & Rooney PC (archer Daniels Midland Company)

20100267096 - Use of a synergistic mixture of water-soluble polymers and hydrophobins for thickening aqueous phases: The invention relates to the use of a synergistic mixture of water-soluble polymers with thickening action and hydrophobins for thickening aqueous phases, and to the degradation of the thickening action by cleaving the protein. The invention further relates to a thickening composition of water-soluble polymers, hydrophobins and water.... Agent: Connolly Bove Lodge & Hutz, LLP

20100267099 - Delta-8 desaturases and their use in making polyunsaturated fatty acids: The present invention relates to Δ8 desaturase genes, which have the ability to convert eicosadienoic acid (EDA; 20:2 ω-6) to dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) and/or eicosatrienoic acid (ETrA; 20:3 ω-3) to eicosatetraenoic acid (ETA; (20:3 ω-3). Isolated nucleic acid fragments and recombinant DNA constructs comprising such fragments encoding Δ8... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100267098 - Delta-9 elongases and their use in making polyunsaturated fatty acids: The present invention relates to Δ49 elongases, which have the ability to convert linoleic acid (LA; 18:2 ω-6) to eicosadienoic acid (EDA; 20:2 ω-6) and/or α-linolenic acid (ALA; 18:3 ω-3) to eicosatrienoic acid (ETrA; 20:3 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ9 elongases along... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100267097 - Fibrous materials and composites: Fibrous materials, compositions that include fibrous materials, and uses of the fibrous materials and compositions are disclosed. For example, the fibrous materials can be operated on by a microorganism to produce ethanol or a by-product, such as a protein or lignin.... Agent: Xyleco, Inc. Celia Leber

20100267100 - Enzymatic synthesis of optically pure beta-hydroxy carboxylic acids and their derivatives: The present disclosure is related to systems, compositions, and methods for producing a β-hydroxy carboxylic acid and/or a β-hydroxy carboxylic amide in enantiomeric excess (e.g., enantiomerically pure). In some specific example embodiments, a method may include contacting a substrate and/or intermediate with a cyanide, a ketoreductase, a nitrilase, and/or a... Agent: Baker Botts L.L.P.

20100267101 - Ethanol production unit and method for the production of ethanol: The invention relates to an ethanol production unit, comprising at least one collecting tank provided with intake means for taking in an aqueous sugar solution, preferably palm juice, a fermentor connected to the collecting tank, for converting the aqueous sugar solution supplied from the collecting tank to a fermented mixture... Agent: Cantor Colburn, LLP

20100267102 - Waste distribution, conversion, and utilization: Food wastes streams may be managed efficiently by co-locating a waste-processing facility including a pulper and an anaerobic bioreactor with a food distribution facility.... Agent: Lando & Anastasi, LLP

20100267103 - Fermentation method of antlers: A method of fermenting animal horny substance, which includes a step of fermenting the mixture of animal horny substance and rice straw in order to ferment animal horny substance by using rice straw, so that not only water-soluble effective components in animal horny substance but also non-water-soluble effective components can... Agent: Hershkovitz & Associates, LLC

20100267106 - Method and circuit arrangement for treating biomaterial: The invention relates to a method for treating biomaterial using at least one electrical field generated by a first voltage pulse which is terminated once the value for an electrical parameter has exceeded or dropped below a preset limit. After the first voltage pulse has been terminated, it is continued... Agent: Joyce Von Natzmer Pequignot + Myers LLC

20100267105 - Method for micromanipulation of cells: The present invention is a method for manipulating living cells in vitro using poly-2-hydroxyethylmethacrylate-coated surfaces and optical tweezers to obtain cells in isolation or to create specific cell-cell interactions.... Agent: Licata & Tyrrell P.C.

20100267104 - Method for the effective delivery of photonic energy to cultures in a fluid medium: A method of preventing bio-filming during the delivery of photonic energy to a culture or set of organisms in a fluid culture medium, the method including introducing a fluid energy-transfer medium into the fluid culture medium through an interface and distributing light into the fluid energy-transfer medium as it is... Agent: Seed Intellectual Property Law Group PLLC

20100267107 - Methods for isolating very small embryonic-like (vsel) stem cells: The presently disclosed subject matter provides methods of isolating populations of stem cells that from bone marrow, peripheral blood, and/or other sources. Also provided are methods of using the stem cells for treating tissue and/or organ damage in a subject.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100267108 - Emulsion-derived particles: An emulsion-derived particle includes a lattice of polymeric strands cross-linked by means of a cross-linking agent, and interstitial openings adjacent and around the strands. Functional groups are provided on the lattice and proteins and/or modified proteins can react with these, thereby to be bonded to the lattice and hence immobilized.... Agent: Myers Bigel Sibley & Sajovec

20100267109 - Spatially inhomogenously functionalized porous media and method for use in selective removal of contaminants: Compositions and methods for separating double-stranded nucleic acids out of a mixture comprising single-stranded nucleic acids and/or dNTPs and/or enzymes. The method uses spatially inhomogenously functionalized nanoporous materials. For example, the compositions and methods of the present invention can be used to purify DNA amplification reaction products.... Agent: Hodgson Russ LLP The Guaranty Building

20100267110 - Laccases, nucleic acids encoding them and methods for making and using them: The invention provides laccases, polynucleotides encoding these enzymes, the methods of making and using these polynucleotides and polypeptides.... Agent: Verenium Corporation Intellectual Property Department

20100267111 - Polypeptide having hadh dependent hmf reductase activity: The invention relates to an isolated polypeptide having NADH dependent HMF reductase activity, wherein said polypeptide shows 80% homology to the amino acid sequence shown in SEQ ID NO:2 and which differs from SEQ ID NO:2 in that at least S117L and Y295 or S110 is substituted, a nucleotide sequence... Agent: Merchant & Gould PC

20100267112 - Use of pks 13 protein coding for condensase of mycolic acids of mycobacteria and related strains as an antibiotics target: The invention relates to a novel enzyme involved in the biosynthesis of mycolic acids and to the use thereof for the screening of antibiotics, especially antimycobacterials. The invention more particularly relates to the Pks13 protein which catalyzes Claisen condensation or malonic condensation in mycolates between an acyl-CoA molecule or an... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100267113 - Active truncated form of the rna polymerase of flavivirus: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100267114 - Glucoamylase variants with altered properties: The present invention relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present invention provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions, animal feed compositions and cleaning compositions. The invention also relates to DNA constructs encoding the variants... Agent: Danisco US Inc. Attention: Legal Department

20100267115 - Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase: Methods of using beta-alanine/pyruvate aminotransferase to produce 3-hydroxypropionic acid and derivatives thereof, from beta-alanine, are disclosed. Cells and recombinant nucleic acids that can be used to practice the methods are also disclosed.... Agent: Klarquist Sparkman, LLP

20100267117 - Bacteriophage having killing activity specific to staphylococcus aureus: The present invention relates to a novel bacteriophage, more precisely a novel bacteriophage having killing activity specific to Staphylococcus aureus which is the causing agent of infectious diseases in human and animals, a pharmaceutical composition for the prevention and treatment of the disease caused by Staphylococcus aureus, an antibiotic and... Agent: Ballard Spahr LLP

20100267116 - Filovirus vectors and noninfectious filovirus-based particles: Cloned filovirus genomic cDNA and methods of using the cDNA are provided. Further provided are noninfectious lipid encapsulated filovirus-based particles.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20100267118 - Recombinational cloning using nucleic acids having recombination sites: Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have the desired characteristic(s) and/or DNA segment(s).... Agent: Life Technologies Corporation C/o Intellevate

20100267119 - Recombinational cloning using nucleic acids having recombination sites: Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have the desired characteristic(s) and/or DNA segment(s).... Agent: Life Technologies Corporation C/o Intellevate

20100267120 - Recombinational cloning using nucleic acids having recombination sites: Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have the desired characteristic(s) and/or DNA segment(s).... Agent: Life Technologies Corporation C/o Intellevate

20100267121 - Recombinant vector containing infectious human cytomegalovirus genome with preserved wild-type characteristics of clinical isolates: A recombinant vector containing infectious genome of human cytomegalovirus (HCMV) and being useful for the production of reconstituted HCMV virus retaining phenotypic characteristics of a clinical virus isolate including the ability to grow on endothelial cells and to induce microfusion is characterized in that it is obtainable by inserting DNA... Agent: Sughrue Mion, PLLC

20100267122 - Microalgae cultivation in a wastewater dominated by carpet mill effluents for biofuel applications: The disclosure encompasses, among other aspects, mixed algal populations able to survive and proliferate on culture media that have a high proportion of carpet industry wastewater. Embodiments further encompass methods of cultivating mixed populations of freshwater and marine alga comprising a plurality of genera and species to provide a biomass... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100267123 - Method for co2 transfer from gas streams to ammonia solutions: A method of recovering carbon dioxide from a stream of flue gases, includes: contacting the stream at a gas pressure above atmospheric pressure with an aqueous solvent system, containing ammonium, carbonate and bicarbonate ions, at a temperature above 10° C. to effect absorption of CO2 from the stream, and separating... Agent: Sughrue Mion, PLLC

20100267124 - Bio-analysis system: To improve operability from collection through to gene analysis, and enable the detection of microorganisms in a short time with good accuracy. Provided is an analysis device 400 which conducts germination of microorganism spores and cell membrane lysis with a collecting chip 200 placed in the analysis device 400, and... Agent: Antonelli, Terry, Stout & Kraus, LLP

20100267126 - Bioreactor apparatus, bioreactor system, and method for growing light energy dependant biological species: The invention relates to a bioreactor apparatus (1) for growing of biological species (2), comprising at least one basin device (3) defining a first habitat (4a) for a first species (2a), and a first lighting device (5a) having one light emitting solid-state lighting source (6), adapted for the first species... Agent: Philips Intellectual Property & Standards

20100267125 - Reactor system and method for processing a process fluid: A reactor is used to grow a process material, such as algae. The reactor may include fluid-cooled light sources and a movable sparger assembly to increase the effective production volume of the reactor.... Agent: Miller, Matthias & Hull

20100267127 - Polymerase chain reaction apparatus: Provided is a polymerase chain reaction (PCR) apparatus. A PCR is performed using the module assembly-type PCR apparatus. The module assembly-type PCR apparatus includes a first module, a second module, and a third module. A sample is provided to the first module. The second module provides different temperature ranges to... Agent: Ampacc Law Group

20100267129 - Chimeric nucleic acids encoding polypeptides comprising domains of tnf family ligands: This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived... Agent: Dla Piper LLP (us)

20100267130 - Chlamydomonas intraflagellar transport 88 (ift-88): The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety, of diagnostic, screening, and therapeutic methods.... Agent: Fish & Richardson PC

20100267128 - Compositions and method for use in isolation of nucleic acid molecules: The present invention relates generally to recombinant genetic technology. More particularly, the present invention relates to compositions and methods for use in selection and isolation of nucleic acid molecules. The invention further relates to methods for the preparation of individual nucleic acid molecules and populations of nucleic acid molecules, as... Agent: Life Technologies Corporation C/o Intellevate

20100267131 - Feline pancreatic lipase: Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Isolated feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Host cells comprising a vector containing the polynucleotide sequences and methods for expressing the polypeptides. The generation of... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100267132 - In vitro preservation of living animal cells and compounds suitable for use in the preservation of living animal cells: o

20100267133 - Acrtiib-fc polynucleotides, polypeptides, and compositions: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuron. The present invention also provides methods of screening compounds that modulate activity of an ActRII protein and/or an ActRII ligand. The compositions and... Agent: Ropes & Gray LLP

20100267136 - Fabrication of vascularized tissue using microfabricated two-dimensional molds: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold... Agent: Edwards Angell Palmer & Dodge LLP

20100267134 - Isolation, characterization and differentiation of in vitro adult human germ line stem cells: t

20100267135 - Multipotent/pluripotent cells and methods: Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100267137 - Methods for inducing the differentiation of blood monocytes into functional dendritic cells: Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood into a plasma component containing proteins, a platelet component and a buffy coat component. A plastic treatment device is provided having plastic channels... Agent: Mccarter & English, LLP Hartford Cityplace I

20100267138 - Compositions and methods comprising a ligand of chemerinr: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related... Agent: Edwards Angell Palmer & Dodge LLP

20100267139 - Osteopontin nanoparticle system for drug delivery: The present invention relates to nanoparticles comprising osteopontin and a polymer carrier, preferably a cationic carrier. Preferably, the cationic carrier is chitosan. Osteopontin and/or the cationic carrier may have bioactivity and/or the nanoparticle may comprise an additional component with bioactivity. Such additional bioactive component may e.g. be a siRNA. The... Agent: Knobbe Martens Olson & Bear LLP

20100267140 - Soluble inhibitors of vascular endothelial growth factor and use thereof: The present invention relates to cDNA encoding a soluble neuropilin protein (sNP) which is isolated from neuropilin (NP) producing cells or is recombinantly engineered from NP-encoding DNA. NP-1 and NP-2 are preferred NPs but any neuropilin or VEGF receptor (VEGFR), where the constituents share at least about 85% homology with... Agent: David S. Resnick

20100267141 - Chemical approaches for generation of induced pluripotent stem cells: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.... Agent: Townsend And Townsend And Crew, LLP

20100267142 - Scalable packed-bed cell culture device: A scalable packed-bed cell culture device includes a matrix vessel, a mixing vessel, a communicating means, a driving means and a controlling means. The matrix vessel includes porous matrixes packed therein. The mixing vessel includes a mixing means configured for mixing a culture medium. The communicating means is connected between... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20100267143 - Method for surface modification of polymeric scaffold for stem cell transplantation using decellularized extracellular matrix: The present invention relates to a method for the surface modification of a polymeric scaffold for stem cell transplantation using a decellularized extracellular matrix. The method for the surface modification of the polymeric scaffold according to the present invention can embody a biomimetic surface environment that is effective for initial... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100267144 - Systems and methods for controlled pervaporation in horticultural cellular tissue: A hypobaric apparatus and methods capable of inducing and maintaining in stored horticultural cellular tissue controlled pervaporation of undesired chemical compounds without reaching the boiling point of intracellular water molecules, comprising a hypobaric chamber constructed to provide a leak rate of less than 4.0 mm Hg per hour, sensors and... Agent: Virginia P. Shogren, P.C.

20100267145 - Immunocompetent cell having anti-cd38 antibody on its cell surface: An immunocompetent cell expressing an anti-CD38 antibody on its surface through genetic introduction of a DNA coding for part of the anti-CD38 antibody; and a method of producing an immunocompetent cell expressing the antibody on its cell surface, which includes amplifying a cDNA using the mRNA coding for part of... Agent: Birch Stewart Kolasch & Birch

20100267146 - Method for expression of small antiviral rna molecules with reduced cytotoxicity within a cell: In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for... Agent: Knobbe Martens Olson & Bear LLP

20100267147 - Site-directed mutagenesis in circular methylated dna: Site-specific mutation in methylated circular stranded DNA molecules is conferred by mutagenic primer pairs and methylase deficient Escherichia coli. The mutagenic primer pairs are complementary at 5′ end or 3′ end, or completely complementary to each other. Firstly, mutagenic primer pair is annealed to opposite strands of the methylated circular... Agent: Miao Qiao Gm Biosciences, Inc

- None available for 10/01/2010

- None available for 10/7/2010

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