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Chemistry: molecular biology and microbiology September class, title,number 09/10

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
09/30/2010 > patent applications in patent subcategories. class, title,number

20100248205 - Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions: Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.... Agent: Fish & Richardson P.C.

20100248206 - Method of isolating stem and progenitor cells from placenta: The present invention provides methods of cryopreserving stem and progenitor cells in a mammalian placenta; and methods of obtaining fetal stem and progenitor cells from a cryopreserved mammalian placenta. Cells obtained by carrying out the methods can be used in a variety of therapeutic applications.... Agent: Bozicevic, Field & Francis LLP

20100248207 - Separation method of biological objects relative to their viscoelastic properties: The present invention relates to a method for the separation of biological objects in a solution which have different viscoelastic properties, wherein said method comprises a filtration step allowing the higher viscoelastic biological objects to pass through the membrane while retaining the lower viscoelastic biological objects above the membrane, and... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20100248208 - Reagent preparing device, reagent preparing method, and specimen processing system: A reagent preparing device capable of supplying a predetermined reagent, which includes a first liquid and a second liquid different from the first liquid, to a measurement section for measuring a specimen using the reagent, comprising: a pressure generator for generating pressure to transfer liquid; a reagent preparing section for... Agent: Brinks Hofer Gilson & Lione

20100248213 - Collection/extraction container for biological material in forensic samples: Relates to a collection/extraction container (1) for collecting solid forensic samples (2) and/or for extracting biological material from these solid forensic samples (2) and its use. The container (1) has a top opening (3) for the insertion of a solid forensic sample (2). The container (1) comprises a basket (7)... Agent: Notaro, Michalos & Zaccaria P.C.

20100248212 - Detection conjugate: The invention relates to a detection conjugate composed of a filament fragment, e.g. a cytoskeletal filament such as actin filaments or microtubules, and recognition elements bound to this fragment as well as kits comprising said detection conjugate and methods how to use said detection conjugate as well as the use... Agent: Merchant & Gould PC

20100248211 - Method for analysis of hepatitis b virus s antigen: An object of the present invention is to enable to accurately quantify HBs antigen in the samples for which measured values are low or false-negative results by the conventional assaying method of HBs antigen. In the method of assaying HBs antigen according to the present invention, at least one inner... Agent: Birch Stewart Kolasch & Birch

20100248214 - Microorganism concentration process: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a particulate concentration agent that comprises gamma-FeO(OH); (b) providing a fluid sample comprising at least one microorganism strain; and (c) contacting the concentration agent with the sample such that at least a portion of the concentration... Agent: 3m Innovative Properties Company

20100248210 - Nucleic acid primer set for detection of drug-resistant strain of hepatitis b virus, assay kit, and method of detecting drug-resistant strain of hepatitis b virus: The invention provides a method of detecting a drug-resistant strain of hepatitis B virus, including amplifying a hepatitis B virus nucleic acid in a sample solution by LAMP with a primer set to yield an amplification product, and hybridizing the amplification product with a probe containing a polynucleotide derived from... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100248217 - Roundworm coproantigen detection: A composition, device, kit and method for detecting the presence or absence of roundworm in a fecal sample. The composition, device, kit and method of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100248215 - Sample preparation container and method: A system and method for preparing and delivering samples for analyte testing. The system can include a sample preparation system and a sample delivery system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition... Agent: 3m Innovative Properties Company

20100248216 - Sample preparation container and method: A system and method for preparing and analyzing samples. The system can include a sample preparation system and a sample detection system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source... Agent: 3m Innovative Properties Company

20100248209 - Three-dimensional integrated circuit for analyte detection: The embodiments of the invention relate to a device having a first substrate comprising a transistor; a second substrate; an insulating layer in between and adjoining the first and second substrates; and an opening within the second substrate, the opening being aligned with the transistor; wherein the transistor is configured... Agent: Pillsbury Winthrop Shaw Pittman LLP (intel)

20100248233 - Acetyl-coa producing enzymes in yeast: The present invention relates to a method of identifying a heterologous polypeptide having enzymatic activity for converting pyruvate, acetaldehyde or acetate into acetyl-CoA in (the cytosol of) a yeast cell comprising: a) providing a mutated yeast cell comprising a deletion of at least one gene of the (PDH) by-pass, selected... Agent: Nixon & Vanderhye, PC

20100248223 - Assessing outcomes for breast cancer patients: This document provides methods and materials related to assessing the likely outcome for mammals (e.g., humans) with cancer (e.g., breast cancer). For example, methods and materials for using the ratio of HOXB13 polypeptide expression to IL-17BR polypeptide expression, CYP2D6 genotype, medication history, or combinations thereof to determine the likelihood of... Agent: Fish & Richardson P.C.

20100248254 - Assessment and reduction of risk of graft-versus-host disease: Methods of assessing and reducing risk of graft versus host disease (GVHD) based on gene expression profiling are described, as well as methods of selecting a suitable transplant donor. Corresponding reagents and kits are also described.... Agent: Merchant & Gould PC

20100248235 - Biomarkers for autism spectrum disorders: Methods of determining the risk of ASD in an individual are provided which comprise identifying the presence of one or more genomic mutations in one or more of the genes, PTCHD1, SHANK3, NFIA, DPP6, DPP10, DYPD, GPR98, PQBP1, ZNF41 and FTSJ1.... Agent: Valentine A Cottrill Susan Tandan

20100248247 - Blood analyzer and method for determining existence and nonexistence of lymphoblasts in blood sample: The invention provides a blood analyzer comprising a blood sample supply section, a sample preparation section for preparing an assay sample by mixing the blood sample with a nucleic acid-staining fluorescent dye, a light source for irradiating the assay sample, an optical detecting section for receiving fluorescence emitted from the... Agent: Sughrue Mion, PLLC

20100248234 - Cancer diagnostic kit and cancer diagnostic method: The present invention provides a kit and method for diagnosing a cancer using a polynucleotide including a nucleotide sequence of SEQ ID No: 1 or 3 or a partial sequence thereof, a polypeptide consisting of an amino acid sequence of SEQ ID No: 2 or 4 or a partial sequence... Agent: Edwards Angell Palmer & Dodge LLP

20100248244 - Characterization of esm-1 as a tumor associated marker of colorectal cancer: Disclosed herein is a colorectal cancer marker for diagnosing colorectal cancer based on ESM-I overexpression in tissues, cells or body fluids of colorectal cancer patients. Disclosed also is the use of the colorectal cancer marker in the development of therapeutic agents for cancer and in the diagnosis and treatment of... Agent: Clark & Elbing LLP

20100248220 - Chlamydia trachomatis specific oligonucleotide sequences: The present invention relates to oligonucleotide sequences for amplification primers and detection probes and to their use in nucleic acid amplification methods for the selective and specific detection of Chlamydia trachomatis in biological samples. The invention also provides oligonucleotide primer sets and primer/probe sets in the form of kits for... Agent: Siemens Corporation Intellectual Property Department

20100248219 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Casimir Jones, S.c.

20100248218 - Conjugates, and use thereof in detection methods: The invention relates to methods for the quantitative and qualitative detection of an analyte in an assay as well as appropriate reagents therefor, especially a carrier molecule to which one or several analyte-specific binding partners are bound and which is provided with additional binding points for a specific binding partner... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100248238 - Detection of bacteria belonging to the genus campylobacter by targeting cytolethal distending toxin: Multiplex PCR primers that can amplify the cdt genes of C. jejuni, C. coli, and C. fetus in a bacterial species-specific manner were prepared. Multiplex PCR with the primers was assessed using Campylobacter bacteria, other cdt gene-positive bacteria, and representative bacteria responsible for enteric infection. As a result, the present... Agent: Bozicevic, Field & Francis LLP

20100248224 - Dna fragmentation assay: The present invention provides methods for the detection of agents that modify the formation of DNA fragmentation in cells. The disclosed methods are configured in an assay format amendable to high throughput screening applications.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100248227 - Drug-phosphorylating enzyme: e

20100248236 - Evaluating genetic disorders: The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify the significance of copy number variations in a subject or subject group.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100248240 - Gene and protein relating to hepatocellular carcinoma and methods of use thereof: The present invention provides a novel human gene ZNFN3A1 whose expression is markedly elevated in a great majority of HCCs compared to corresponding non-cancerous liver tissues. The gene encodes a protein having a zinc finger domain as well as a SET domain and has been found to form a regulatory... Agent: Mintz Levin Cohn Ferris Glovsky And Popeo, P.C.

20100248225 - Gene expression profiling for identification, monitoring and treatment of melanoma: A method is provided in various embodiments for determining a profile data set for a subject with skin cancer or a condition related to skin cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100248231 - High specificity and high sensitivity detection based on steric hindrance & enzyme-related signal amplification: The present invention relates to a molecular probe capable of high sensitivity and high specificity detection of target nucleic acid in a sample. Also disclosed is a detection method using this probe.... Agent: Townsend And Townsend And Crew, LLP

20100248245 - Integrated apparatus for conducting and monitoring chemical reactions: Apparatus for conducting and monitoring chemical reactions comprises a base and a thermal cycler mounted on the base. A plurality of heat-conducting receptacles are mounted on the thermal cycler and in heat-communication therewith. Each receptacle comprises an opaque body defining a bore having an open end, a first window, and... Agent: Klarquist Sparkman, LLP

20100248229 - Invitro human embryonic model and a method thereof: The present invention relates to the field of stem cells particularly development of a novel human embryonic model using human embryoid bodies obtained from the human embryonic stem cell. The novel human embryonic model disclosed thus can provide a screening assay for determining the toxic activity of the compound and/or... Agent: Oliff & Berridge, PLC

20100248243 - Method and arrangement for calibrating a sensor element: A method is disclosed for calibrating a sensor element, which has an immobilized probe oligonucleotide, via which the bonding of a target nucleic acid (Z) can be detected by the sensor. In at least one embodiment, the method includes: a) bringing the sensor element into contact with a control nucleic... Agent: Harness, Dickey & Pierce, P.L.C

20100248253 - Method and kit for assessing risk of gout and hyperuricemia: A method for assessing a risk of suffering from a gout of a subject is provided. The method includes steps of obtaining a nucleotide sample from the subject; determining a genetic polymorphism of one of a Urate transporter 1 (URAT1) gene and an alpha-kinase 1 (ALPK1) gene in the nucleotide... Agent: Volpe And Koenig, P.C.

20100248228 - Method for detecting dna methylation in cancer cells: The present invention provides a detecting method of detecting malignant cells in a patient's specimen or a biological sample. Specifically, the inventive method includes the steps of extracting a genomic DNA, digesting said genomic DNA with one or multiple methylation sensitive restriction enzymes, and amplifying by PCR with one or... Agent: University Of Missouri System Office Of Intellectual Property Admin.

20100248221 - Method for identification of organism by dna tag: The object is to provide a novel organism identification method which can be used as an alternative method to a conventional organism identification method which utilizes DNA and requires enormous labor. Developed is an organism identification method for determining whether or not an organism of interest is identical to a... Agent: Birch Stewart Kolasch & Birch

20100248250 - Method for preparing stool sample, solution for preparing stool sample, and kit for collecting stool: Provided in the present invention are a method for preparing a stool sample without any need for complicated operations which is capable of efficiently recovering a nucleic acid or the like originating from mammalian cells, such as the cells exfoliated from the large intestine, in the stool; a solution for... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100248222 - Method of forming signal probe-polymer: Provided are a method of forming a signal probe-polymer which makes it possible to form a polymer efficiently and quantitatively, a signal probe-polymer formed by the method, oligonucleotide probes for use in the method, and a method of detecting target analyte having high sensitivity and excellent quantitative capability. The method... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100248239 - Methods and materials for detecting fragile x mutations: This document relates to methods and materials involved in detecting Fragile X mutations and assessing the methylation state of Fragile X alleles. For example, methods and materials for detecting Fragile X alleles using polymerase chain reaction and a hybridization probe (e.g., a non-radioactively labeled hybridization probe) are provided.... Agent: Fish & Richardson P.C.

20100248252 - Methods for analysis of molecular events: Methods and compositions are provided for detecting the presence of nucleic acid sequence variants in a subpopulation of nucleic acid molecules in a biological sample. These methods are particularly useful for identifying individuals with mutations indicative of cancer.... Agent: Choate, Hall & Stewart LLP

20100248249 - Methods for assessing cancer for increased sensitivity to 10-propargyl-10-deazaaminopterin by assessing egfr levels: The present invention relates to a method for assessing the sensitivity of a patient's cancer to treatment with 10-propargyl-10-deazaminopterin and a method for selecting a patient for treatment of cancer with 10-propargyl-10-deazaminopterin, by determining the amount of a EGFR or other growth factor expressed by the cancer and comparing the... Agent: Swanson & Bratschun, L.L.C.

20100248232 - Methods for determining the presence or absence of elite event ms-bn1 in brassica plant material: This invention relates to transgenic winter oilseed rape (WOSR) plants, plant material and seeds, harboring a specific transformation event. It pertains to winter oilseed rape plants, more particularly to a pair of winter oilseed rape plants, which is particularly suited for the production of hybrid seed. More specifically, one plant... Agent: Frommer Lawrence & Haug

20100248226 - Methods for measuring cell response to dna damaging agents using promyelocytic leukemia protein nuclear bodies: Methods for assessing the potential efficacy of a DNA-damaging agent as a tumour treatment or for monitoring the efficacy of such treatment by determining promyelocytic leukemia protein nuclear body (PML NB) properties of the tumour are disclosed. PML NB properties, including morphology, number and biochemical composition, of cells or tissue... Agent: Knobbe Martens Olson & Bear LLP

20100248246 - Methods of enriching for and identifying polymorphisms: The invention encompasses methods for enriching for and identifying a polymorphism within a nucleic acid sample either by separating a subset of a nucleic acid sample or by selectively replicating a subset of a nucleic acid sample such that the polymorphism is contained within a nucleic acid population with reduced... Agent: Edwards Angell Palmer & Dodge LLP

20100248237 - Miniaturized, high-throughput nucleic acid analysis: The present invention is directed to method for analyzing multiple nucleic acid molecules of interest comprising in the steps of (i) providing a plurality of beads, characterized in that each bead comprises at least two sequence specific amplification primers, further characterized in that at least one of the primers is... Agent: Roche Diagnostics Operations Inc.

20100248241 - Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind... Agent: Ropes & Gray LLP

20100248230 - Novel medical diagnostic method and therapy in the context of interfreon-stimulated genes that induce depression: The invention relates to a novel medical diagnostic method and treatment in conjunction with depression-inducing genes which are stimulated in particular by interferon. The invention relates in particular to the use of at least one nucleic acid molecule which induces depression and/or is associated with depression, in particular a gene... Agent: Brannon & Sowers PC

20100248242 - Process for concentrating nucleic acid molecules: A process concentrates nucleic acid molecules to be detected of a sample on a surface, with capture molecules that specifically bind the nucleic acid molecules. A support material has a capture probe that can specifically be linked to the nucleic acid molecules to be detected to give complexes. The support... Agent: Staas & Halsey LLP

20100248251 - Tissue rejection: This document relates to methods and materials involved in detecting tissue rejection (e.g., organ rejection). For example, this document relates to methods and materials involved in the early detection of kidney tissue rejection.... Agent: Fish & Richardson P.C.

20100248248 - Use of the serological assay of the cytokine b-lymphocyte stimulator (blys) as a prognostic and monitoring test for immune-related transfusion reactions: The use for the serum quantification of the cytokine B-Lymphocyte Stimulator (BLyS) for the evaluation of the risk of immunization and transfusion reactions after blood transfusion, and for the monitoring of patients undergoing blood transfusion or re-transfusion in a patient that includes an initial step of taking a sample of... Agent: Panitch Schwarze Belisario & Nadel LLP

20100248262 - Anti-fibronectin fragment monoclonal antibody: A method for measuring a fibronectin fragment which is easy to handle and has excellent measuring accuracy, specificity and reproducibility is provided. An anti-fibronectin fragment monoclonal antibody which reacts with a human fibronectin fragment but does not react with human fibronectin, a measuring reagent containing the monoclonal antibody, a method... Agent: Banner & Witcoff, Ltd. Attorneys For Client No. 016689

20100248257 - Compiled methods for analysing and sorting samples: The present invention relates to the fields of analysis, diagnostics, prognostics, standardization, characterization and enumeration of entities such as biological cells, as well as therapeutical applications. Accordingly, the present invention in preferred aspects is directed to methods for the detection and/or analysis and/or isolation and optionally further manipulation of entities,... Agent: King & Spalding

20100248260 - Glycosaminoglycan-coated particles and uses thereof: The present invention is directed to metallic particles coated with glycosaminoglycans and methods for preparing them. Methods of using such glycosaminoglycan-coated metallic particles in biomedical and other applications are also disclosed. In certain embodiments, methods for assaying glycosaminoglycan-degrading activity in biological fluids, test samples, and/or therapeutic formulations using the glycosaminoglycan-coated... Agent: Choate, Hall & Stewart LLP

20100248256 - Hepatocellular carcinoma protein marker, and method for detection of hepatocellular carcinoma using the same: Provided are: a method of assessing hepatocellular carcinoma by using a protein with a different phosphorylated state in hepatocellular carcinoma cells compared with non-hepatocellular carcinoma cells; and a hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma formed of the protein. The hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma includes... Agent: Mcginn Intellectual Property Law Group, PLLC

20100248258 - Immunoassay biochip: The present invention is about a microfluidic chip for rapid detection of different target proteins and a method for using the same. The microfluidic chip utilizes antibody-conjugated magnetic beads to bind to the target proteins to form a magnetic complex, and then use the signal labeled-antibodies that can recognize said... Agent: Bacon & Thomas, PLLC

20100248261 - Method to determine protein interaction sites: The invention provides improved crosslinkers which permit more efficient determination of protein interactions in biological samples.... Agent: Morrison & Foerster LLP

20100248259 - Natriuretic peptide/gdf-15 ratio for diagnosis of cardiac disorders: The present invention is concerned with methods and devices for medical diagnosis. Specifically, it relates to a method of diagnosing a cardiac disorder, the method including (a) determining the amount of a natriuretic peptide in a sample of the subject, (b) determining the amount of GDF-15 in a sample of... Agent: Roche Diagnostics Operations Inc.

20100248255 - Novel peptides: The present invention provides novel peptides with circulation-modulating activity. These peptides are useful as circulation-modulating agents and vasopressors because of their circulation-modulating activity, and can be used for treating diseases of the circulatory system such as myocardial infarction, ischemic heart disease, cerebral infarction, or the like.... Agent: Townsend And Townsend And Crew, LLP

20100248266 - Purinergic (p2x) receptors in extra-cellular body fluid: The invention relates to purinergic (P2X) receptors, to detection of protein in extra-cellular body fluids and to antibodies for the diagnosis of a disease or condition, especially cancer.... Agent: Townsend And Townsend And Crew, LLP

20100248267 - Method for measurement of concentration of antigen: The object of the present invention is to provide a detection method that can detect an antigen even if the target antigen has a low molecular weight in a simpler, more efficient, and more stable manner and with higher sensitivity. The detection of the antigen is carried out by using... Agent: Cadwalader, Wickersham & Taft LLP

20100248263 - Biomarkers associated with age-related macular degeneration: The invention relates to proteins associated with age-related macular degeneration (AMD). These proteins, which are present in blood, are expressed in individuals with AMD at either elevated or reduced levels compared to healthy individuals. The invention provides methods for diagnosing AMD. The invention provides methods for assessing the efficacy of... Agent: Townsend And Townsend And Crew, LLP

20100248264 - Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures.... Agent: K&l Gates LLP

20100248268 - Methods to utilize invertebrate chemosensory proteins for industrial and commercial uses: This invention provides methods and compositions for using chemosensory proteins derived from invertebrates to bind or detect specific compounds. Applications include use as detector elements in biosensors or other sensory devices and purification or concentration devices. Examples of proteins involved in the chemosensory pathway include odorant binding proteins (OBPs), sensory... Agent: David R Preston & Associates Apc

20100248265 - Compositions and methods for diagnosis and treatment of cancer: Provided herein are methods and compositions useful in the diagnosis and treatment of cancer. The methods and compositions typically involve detecting a level of phosphorylation of mTOR at serine 2481 in a subject and comparing the level of phosphorylation of mTOR at serine 2481 in said subject with a standard... Agent: Townsend And Townsend And Crew, LLP

20100248269 - Detection of fibrin and fibrinogen degradation products and associated methods of production and use for the detection and monitoring of cancer: Disclosed herein are methods, systems and kits for the detection of, or monitoring the progression of, cancer by simultaneously detecting the presence of six fibrin and fibrinogen degradation products (FDP) in a biological sample in a single assay system.... Agent: K&l Gates LLP

20100248271 - Fibrinogen alpha and hemoglobin polypeptides as cancer markers: The present invention provides methods of detecting cancer using biomarkers.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100248270 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease: Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100248272 - Method for identifying smk box riboswitch modulating compounds: The invention is directed, inter alia, to a method for identifying a compound that modulates a gene expression of an mRNA molecule containing a SMK box riboswitch that contains a SAM binding pocket, wherein the mRNA molecule is produced by a lactic acid bacteria, the method comprising: (i) generating a... Agent: Scully Scott Murphy & Presser, PC

20100248273 - Amelioration of heterophile antibody immunosensor interference: The invention is directed to methods and devices for reducing interference from heterophile antibodies in an analyte immunoassay. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with non-human IgM or fragments thereof by dissolving... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20100248274 - Antibody directed against pro-gastrin releasing peptide, and use thereof: Disclosed is a novel high-sensitive ProGRP measurement method, which is free from problems such as the fluctuations in measurement values and the operational constraints (e.g., the constraints on the handling of a sample). Specifically disclosed is a method for the measurement of a gastrin-releasing peptide precursor and/or a digested product... Agent: Edwards Angell Palmer & Dodge LLP

20100248275 - Methods for predicting outcome in traumatic brain injury: The invention describes methods for predicting outcome for patients suffering from traumatic brain injury (TBI) by evaluating levels of markers commonly associated with cellular damage in bodily fluids. Utilization of such methods improves diagnosis and treatment of patients suffering from traumatic brain injury, thus potentially minimizing and/or eliminating long-term adverse... Agent: Cooley LLP Attn: Patent Group

20100248277 - Detection and quantification of analytes in bodily fluids: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100248276 - Method for measuring low density lipoprotein cholesterol: It is an object of the present invention to provide a method for measuring low density lipoprotein cholesterol (LDL-C) in a body fluid, which is able to selectively measure low density lipoprotein cholesterol in a body fluid without using a low density lipoprotein cholesterol-selective surfactant having a risk of generating... Agent: Young & Thompson

20100248278 - Method and a device for characterizing the coagulation or sedimentation dynamics of a fluid such as blood or blood plasma: A method of characterizing the coagulation or sedimentation dynamics of a fluid such as whole blood, a blood fraction, or blood plasma, the method comprising: illuminating a sample of said fluid with a beam of coherent light; acquiring a time series of images of a speckle pattern generated by interaction... Agent: Alston & Bird LLP

20100248279 - Substrate probe, enzyme-activity detection method by a multi-dimensional nuclear magnetic resonance method and enzyme-activity imaging method: Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional... Agent: Fitzpatrick Cella Harper & Scinto

20100248280 - Method for identifying a compound that modulates telomerase activity: The present invention relates to a method for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain of telomerase and testing... Agent: Licata & Tyrrell P.C.

20100248281 - Rapid detection of replicating cells: The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining... Agent: Clark & Elbing LLP

20100248282 - Detection of no by using guanylyl cyclase and cgmp production as a readout system: The present invention relates to a method for determining NO enzymatically and its use for the identification of substances which can modulate a nitric oxide synthase activity.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100248284 - Biosensor: A biosensor which comprises a substrate (101) having a buried electronic sensing element and a substrate surface (124) above the buried electronic sensing element; a structured top layer (125) covering the substrate surface (124), having a top surface above the substrate surface (124), and comprising at least one stimulation and/or... Agent: Connolly Bove Lodge & Hutz LLP

20100248286 - Biosensors based on microalgae for the detection of environmental pollutants: The present invention provides biosensors based on microalgae for the determination of the presence of toxic compounds in a sample, characterized by the high sensitivity and specificity thereof with respect to the target toxic substance. The biosensors are based on the measurement of the photosynthetic activity of algae by means... Agent: Ostrolenk Faber Gerb & Soffen

20100248287 - Decontamination of prion-contaminated surfaces with phenols: A method of decontaminating a surface or liquid which is contaminated with prions includes treating the surface with a composition which includes one or more phenol. Phenols which are particularly effective include p-chloro-m-xylanol, thymol, triclosan, 4-chloro, 3-methylphenol, pentachlorophenol, hexachlorophene, 2,2-methyl-bis(4-chlorophenol), and p-phenylphenol.... Agent: Renner Otto Boisselle & Sklar, LLP

20100248288 - Differentiation of causes of right heart failure: The present invention relates to the field of diagnostic means and methods. More specifically, the present invention relates to a method of differentiating between pulmonary embolism and pulmonary hypertension as the cause of right heart failure in a subject comprising determining the amounts of a natriuretic peptide, a cardiac troponin,... Agent: Roche Diagnostics Operations Inc.

20100248285 - Method and apparatus for the processing and/or analysis and/or selection of particles, in particular biological particles: Methods and apparatus are described for the processing (for example washing, incubation, etc.) of particles in which the particles suspended in a first fluid are introduced under laminar flow conditions into at least one first microchamber or first region of the same, in which a second fluid is introduced under... Agent: Jeffrey J. King, Esq. Black Lowe & Graham PLLC

20100248290 - Methods for detecting lung cancer and monitoring treatment response: A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated... Agent: Borden Ladner Gervais LLP Anne Kinsman

20100248291 - Methods for identifying, purifying and enriching immature or stem cancer-initiating cells from tumors and use thereof: The present invention is related to methods for the preparation of cell compositions, isolated compositions obtainable therefrom, related isolated cell compositions, kits and use thereof. More specifically, the present invention provides a method for identifying, purifying and enriching immature or stem cancer-initiating cells in a 5 sample. The cell compositions,... Agent: Hoffmann & Baron, LLP

20100248283 - Portable surface plasmon resonance biosensor: A surface plasmon resonance biosensor device and system are provided. The simplicity of SPR biosensor design allows easy integration with both QCM and electrochemistry techniques, not found in current SPR biosensor devices. In some embodiments, the surface plasmon resonance biosensor device has a dual SPR/QCM sample holder which allows simultaneous... Agent: Ian C. Mcleod Mcleod & Moyne, P.C.

20100248289 - Reagent preparing device, reagent preparing method and specimen processing system: A reagent preparing device for preparing a reagent to be supplied to a measurement section for measuring a specimen; the reagent preparing device comprising: a reagent preparing section for preparing a reagent including a first liquid and a second liquid, different from the first liquid; a reagent storage container, connected... Agent: Brinks Hofer Gilson & Lione

20100248293 - Sample analyzer and sample analyzing method: The present invention is to present a sample analyzer comprising: a first measurement unit; a second measurement unit; a transport unit for transporting a sample container to the first measurement unit and the second measurement unit; and a controller configured to perform operations comprising: obtaining measurement item information indicating a... Agent: Sughrue Mion, PLLC

20100248292 - Sample processing apparatus and sample processing method: A sample processing apparatus comprising: an aspiration section for aspirating a sample from a sample container; a sample container take-out/returning section for taking out a sample container containing a sample from a sample rack holding a plurality of sample containers, and for returning the sample container, from which the sample... Agent: Sughrue Mion, PLLC

20100248294 - Analytic substrate coating method: An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably... Agent: Dunlap Codding, P.C.

20100248295 - Analytic substrate coating method: An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably... Agent: Dunlap Codding, P.C.

20100248296 - Sterilization indicator: The disclosed technology relates to a sterilization indicator and a process to concentrate signal generated by constraining it to a minimal surface, in a minimal volume and minimal pH and growth buffering or mediating influences. The sterilization indicator may comprise a carrier 12, the carrier having a first surface 14... Agent: Renner Otto Boisselle & Sklar, LLP

20100248298 - Mass spectrometric identification of microorganisms in complex samples: Microorganisms are identified as present in a complex sample or mixed culture by acquiring a mass spectrum of the sample and comparing it to combination spectra, each of which is formed by combining at least two reference mass spectra of known microorganisms. Microorganisms corresponding to the reference spectra used to... Agent: Law Offices Of Paul E. Kudirka

20100248299 - Microbial detection and quantification: Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in... Agent: Dority & Manning, P.A.

20100248297 - Particles and manufacturing methods thereof: Particles and manufacturing methods thereof are provided. The manufacturing method of the particle includes providing a precursor solution containing a precursor dissolved in a solution, and irradiating the precursor solution with a high energy and high flux radiation beam to convert the precursor to nano-particles. Particles with desired dispersion, shape,... Agent: Pai Patent & Trademark Law Firm

20100248300 - Blood analyzer, blood analyzing method, and computer program product: A blood analyzer comprising: a specimen preparation section for preparing a measurement specimen that is used to measure a white blood cell count among CBC measurement items; a measurement section for obtaining optical information from blood cells contained in the measurement specimen; and a controller carrying out operations comprising: classifying... Agent: Brinks Hofer Gilson & Lione

20100248302 - Method of determining sperm capacitation: This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with acrosomal exocytosis. Accordingly, the present invention discloses a method for determining the ability of sperm... Agent: Hodgson Russ LLP The Guaranty Building

20100248301 - Tissue embedding apparatus, and method for operating a tissue embedding apparatus: The present invention relates to a tissue embedding apparatus (1) for automatic embedding of at least one tissue sample (8). The tissue embedding apparatus (1) encompasses an input unit (2), an image acquisition unit (3), an embedding unit (4), at least one output unit (5, 6), and a control unit... Agent: Hodgson Russ LLP The Guaranty Building

20100248303 - Method for recovering peptides/amino acids and oil/fat from one or more protein-containing raw materials, products produced by the method, and use of the products: According to a first aspect, hydrolysation of a protein-containing raw material and separation of amino acids/peptides is carried out, wherein the hydrolysation is effected by using the endogenous enzymes of the protein-containing raw material. The hydrolysate is passed through a membrane filter, wherein peptide/amino acids follow a permeate stream, whilst... Agent: Virtual Law Partners LLP

20100248304 - Dual expression vector system and screening methods: The present invention features vectors that contain a promoter effective for expression in bacterial cells and a promoter effective for expression in insect cells. The dual promoter system allows use of the same vector in both host cell systems so that construction of only a single vector is needed to... Agent: Vertex Pharmaceuticals Inc.

20100248306 - Expression system for the antibiotic-free production of polypeptides: The invention relates to an expression system for the production of one or more target polypeptide/target polypeptides, comprising a host cell in whose genome the DNA sequence that codes glycerine-3-phosphate dehydrogenase is inactivated or partially or completely deleted and which is transformed by an extrachromosomal element that comprises a DNA... Agent: Edwards Angell Palmer & Dodge LLP

20100248307 - Peptide production method: According to the present invention, a protein having peptide-synthesizing activity, a DNA encoding the protein, a recombinant DNA containing the DNA, a transformant obtained via transformation with the recombinant DNA, a process for producing a protein having peptide-synthesizing activity using the transformant and the like, a process for producing a... Agent: Fitzpatrick Cella Harper & Scinto

20100248305 - Polyamino acid synthetase and gene encoding the same: The present invention provides an enzyme which catalyzes amino acid polymerization in the form of a non-ribosomal peptide synthetase (NRPS) and a gene encoding the same.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100248308 - Recombinant microorganism and a method for producing poly-gamma-glutamic acid: A recombinant microorganism having poly-γ-glutamic acid-producing ability, prepared by introducing a Bacillus subtilis pgsB gene or a gene functionally equivalent thereto, and a Bacillus subtilis pgsC gene or a gene functionally equivalent thereto, among a group of genes relating to synthesis of poly-γ-glutamic acid, into a host microorganism, in which... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100248309 - Thermostable alpha1-antitrypsin mutein with a disulfide bond and the method for preparing it: The present invention relates to a thermostable alpha-1-antitrypsin mutein with a disulfide bond and a preparation method of the same, more precisely an alpha-1-antitrypsin mutein with improved thermostability, compared with the conventional thermostable alpha-1-antitrypsin mutein (Korean Patent No. 133252), resulted from the process of substituting the 168th and 189th amino... Agent: Klarquist Sparkman, LLP

20100248310 - Method of dna amplification: The present invention relates generally to a method of amplifying a nucleic acid region of interest and, more particularly, to a method of amplifying a nucleic acid region of interest using a PCR method designed to minimise the generation of amplicons from primers which have bound to nucleic acid regions... Agent: Knobbe Martens Olson & Bear LLP

20100248311 - Increasing methionine yield: Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100248312 - Alanine 2,3-aminomutases and related polynucleotides: The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.... Agent: Codexis, Inc.

20100248313 - Novel optically active, heteroaromatic beta-hydroxy esters and processes for their preparation from beta-keto esters and processes for the preparation of these beta-keto esters: The present invention relates to new optically active heteroaromatic β-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.... Agent: Millen, White, Zelano & Branigan, P.C.

20100248314 - Process for production of succinic acid amide compound: Disclosed is a novel process for producing a compound represented by the general formula (1) by using a microorganism, wherein the compound is useful as a plant growth stimulant. Specifically disclosed is a process for producing a succinic acid amide compound represented by the general formula (1) [wherein Ar represents... Agent: Birch Stewart Kolasch & Birch

20100248315 - Fermentative vitamin c production: The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the... Agent: Nixon & Vanderhye, PC

20100248316 - Process for the production of ambrafuran: A method for the cyclodehydration of a 1,4- or 1,5-diol includes the step of exposing a 1,4- or a 1,5-diol to an activated zeolite at a temperature of between about 0° C. and about 110° C. for a period of between about 1 and 24 hours. The activated zeolite is... Agent: Marshall, Gerstein & Borun LLP

20100248317 - Process for the enantioselective enzymatic reduction of intermediates: m

20100248318 - Hydrogen processing and impurity removal and cleaning methods in a biomass conversion process: In one embodiment, the disclosure includes a method of biomass conversion including fermenting biomass to produce a carboxylic acid or carboxylate salt and hydrogen gas, recovering the hydrogen gas, and converting the carboxylic acid or carboxylate salt to an alcohol using the hydrogen gas. In one embodiment, the hydrogen produced... Agent: Conley Rose, P.C. David A. Rose

20100248319 - Ethanol production: This invention relates to ethanol production as a product of bacterial fermentation.... Agent: Banner & Witcoff, Ltd.

20100248320 - Compositions and methods for conversion of lignocellulosic material to fermentable sugars and products produced therefrom: The present invention relates to compositions and methods for the conversion of lignocellulosic material to fermentable sugars and to products produced therefrom (e.g., ethanol, foodstuffs, etc.). In particular, the invention provides lignocellulose-degrading compositions (e.g., generated via incubation of microbes with lignocellulosic priming feedstock in solid-state fermentation format) and methods of... Agent: Casimir Jones, S. C.

20100248321 - Surfactant amendments for the stimulation of biogenic gas generation in deposits of carbonaceous materials: Methods of conditioning a carbonaceous material in a subterranean geologic formation for metabolism into a compound with enhanced hydrogen content by a microorganism consortium are described. The methods may include the steps of accessing the subterranean geologic formation through an access point, and contacting the carbonaceous material with a surfactant.... Agent: Townsend And Townsend And Crew, LLP

20100248322 - Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material: Methods of stimulating biogenic production of a metabolic product with enhanced hydrogen content are described. The methods may include accessing a geologic formation that includes carbonaceous material. The methods may also include introducing an amendment to the geologic formation. The amendments may further include removing compounds with enhanced hydrogen content... Agent: Townsend And Townsend And Crew, LLP

20100248323 - Carbonic anhydrase bioreactor and process for co2 containing gas effluent treatment: A triphasic bioreactor for physico-chemically treating a gas is disclosed. The triphasic bioreactor comprises a reaction chamber with a liquid and biocatalysts in suspension in the liquid, for catalyzing a reaction between the gas and the liquid to obtain a treated gas and a solution containing a reaction product. A... Agent: Ware Fressola Van Der Sluys & Adolphson, LLP

20100248324 - Expandable functional tfe copolymer fine powder, the expandable functional products obtained therefrom and reaction of the expanded products: A functional TFE copolymer fine powder is described, wherein the TFE copolymer is a polymer of TFE and at least one functional comonomer, and wherein the TFE copolymer has functional groups that are pendant to the polymer chain. The functional TFE copolymer fine powder resin is paste extrudable and expandable.... Agent: Gore Enterprise Holdings, Inc.

20100248325 - Self-crosslinking polysiloxanes in coatings of enzyme immobilizates: Enzyme preparations obtainable by providing an enzyme immobilizate with a silicone coating, the coating being obtained by hydrosilylating a self-crosslinking polysiloxane, a process for production thereof and the use thereof are provided.... Agent: Scully Scott Murphy & Presser, PC

20100248326 - Stabilization of thermolysin in aqueous solution: The present invention deals with the proteolytic enzyme thermolysin which tends to be unstable in aqueous solution. The invention provides methods and compositions to enhance the stability of dissolved thermolysin in aqueous solution. Thermolysin, crude thermolysin or a lyophilisate containing thermolysin and one or more salts, is contacted with an... Agent: Roche Diagnostics Operations Inc.

20100248327 - Cytochrome p450 oxygenases: Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100248328 - Hyperactive variants of 5-aminolevulinate synthase and methods of use: The rate of porphyrin biosynthesis in mammals is controlled by the activity of the pyridoxal 5′-phosphate-dependent enzyme 5-aminolevulinate synthase. Assuming the turnover in this enzyme is controlled by conformational dynamics at a highly conserved active site loop, a variant library was constructed by targeting imperfectly conserved non-catalytic loop residues and... Agent: Smith Hopen, Pa

20100248329 - Blood coagulation promoter and blood collection tube: The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability, and a blood collection tube accommodating the blood coagulation promoter. The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a... Agent: Cheng Law Group, PLLC

20100248330 - Flow-controlling header: An apparatus and method for holding a membrane, screen or other flexible planar body in tension, while providing a conduit for water or other liquid to flow to the membrane being held. The membrane extends from inside a manifold body that carries the liquid, and the manifold body supports the... Agent: Kremblas & Foster

20100248331 - Selective growth media: Disclosed is a method of selectively inhibiting for growth of non-target cells in a mixed population of target and non-target cells, the method comprising the steps of: (a) contacting the mixed population with a selective agent which comprises a carrier moiety linked by a scissile linkage to a toxic moiety;... Agent: Rader, Fishman & Grauer PLLC

20100248332 - Yeast used for pizza and its production method: A yeast used for pizza and its production method are provided. The yeast is dry yeast, and the amount of CO2 produced in the dough at 30° C. during 60 minutes is 250˜450 mL CO2/h, wherein the dough contains those ingredients as following: 280 g flour, 1.43% salt by weigh... Agent: The Nath Law Group

20100248333 - Photobioreactor system and method for the growth of algae for biofuels and related products: A photobioreactor includes an upper layer of transparent film and a lower layer of film wherein the upper layer and lower layer are attached to each other along the perimeter to form a sealed structure, the upper layer and lower layer also attached to form pathways comprising independent channels within... Agent: Woodcock Washburn LLP

20100248334 - Biological active coating components, coatings, and coated surfaces: Disclosed herein are novel coatings and paints comprising a biomolecule composition, wherein the biomolecule composition comprises a phosphoric triester hydrolase. Also disclosed herein are methods of detoxification of a surface contaminated with an organophosphorus compound by contacting the surface with such a coating or paint. Also disclosed herein are novel... Agent: Daffer Mcdaniel, LLP

20100248335 - Method and apparatus for treatment of organic waste: The pH condition in a methane fermentation tank is adjusted in a predetermined range equal to or less than the intended pH condition causing no scale formation, while being maintained in a predetermined range approximate to an optimized pH condition suitable for methane fermentation, and thereby the formation of inorganic... Agent: Kusner & Jaffe Highland Place Suite 310

20100248336 - Methods for purifying nucleic acids: Methods are provided for producing highly purified compositions of nucleic acids by using a highly streamlined and readily automated process. The methods use static mixers for lysing cells and precipitating debris, following by centrifugation and ion exchange chromatography. The process may include a purification step using tangential flow ultrafiltration. A... Agent: Borson Law Group, PC

20100248337 - Process for the production of (s)-5-chloro-2-isopropylpent-4-enoic acid esters: A process for preparing a compound of formula (1) in enantiomerically enriched form, which comprises selective hydrolysis of the corresponding racemic compound (2) catalysed by an enzyme derived from a non-mammalian source and having esterase or lipase activity, wherein R is methyl or C2-10 linear or branched alkyl.... Agent: Dr. Reddy''s Laboratories, Inc.

20100248338 - Cell treatment device, cell treatment cartridge and body fluid treatment system: A cell treatment device which allows cell dispersion liquid including cancer cells to pass therethrough to cause at least the cancer cells to be subjected to at least one of a physical action, a chemical action, and a biologically activating action, includes: a slit member having a first surface and... Agent: Harness, Dickey & Pierce, P.L.C

20100248340 - Needle: A needle designed to be manipulated on a single cell includes a cantilever tip including a support unit and a tip unit formed at a prescribed angle to the support unit, and a shaft connected to the cantilever tip. The needle is attachable, via at least the shaft, to a... Agent: Scully Scott Murphy & Presser, PC

20100248339 - Tip drive apparatus: A tip, drive apparatus is capable to moving a tip unit toward an object, while holding the tip unit at a prescribed angle. The tip unit is formed on a support unit having flexibility and directed to the object at the prescribed angle. The tip drive apparatus includes a needle... Agent: Scully Scott Murphy & Presser, PC

20100248341 - Tip drive apparatus: A tip drive apparatus includes a shaft to which a support unit on which a tip unit is formed, and a main unit configured to move the shaft, thereby to move the tip unit toward an object while remaining held at a prescribed angle. The shaft is arranged to meet... Agent: Scully Scott Murphy & Presser, PC

20100248342 - Tip drive apparatus and cantilever tip: A tip drive apparatus is capable to moving a tip unit toward an object, while holding the tip unit at a prescribed angle. The tip unit is formed on a support unit having flexibility and directed to the object at the prescribed angle. The tip unit includes a contact side... Agent: Scully Scott Murphy & Presser, PC

20100248343 - Methods and devices for charged molecule manipulation: Devices and methods for constraining or holding a cell are provided. In one aspect, for example, a cellular constraint device is provided. Such a device can include a support surface and at least one constraining arm movably coupled to the support surface. The constraining arm has a first position in... Agent: Thorpe North & Western, LLP.

20100248344 - Methanogenic reactor: A methanogenic reactor for the production of methane, cellular biomass and other useful products for use in the manufacturing of specialty chemicals. The methanogenic reactor includes a bottom wall, perimeter wall, and top wall defining an interior space environmentally separable from an exterior space outside of the reactor vessel for... Agent: Ekse Law Firm, PC

20100248346 - Analyzer: An analyzer comprising: a housing comprising a first space therein; a reagent accommodation section, disposed in the housing, comprising a second space therein for accommodating a reagent container containing a reagent, and an air induction port for inducting air from the first space to the second space; and a cooler... Agent: Sughrue Mion, PLLC

20100248347 - Diagnostic support apparatus for renal disease and computer program product: The present invention is to present a diagnostic support apparatus for renal disease, comprising: a red blood cell information obtainer for obtaining at least one of red blood cell numerical information representing the number of red blood cells in a urine sample, and red blood cell morphological information representing morphology... Agent: Brinks Hofer Gilson & Lione

20100248345 - Particle facilitated testing: Magnetic particles are distributed across a fluid flow by applied magnetic field to interact with a test substance in fluid. Alternatively or additionally, particles, which may be magnetic, are combined with cells and energy, e.g. ultrasonic energy, is applied to cause the particles to create a lysate. Alternatively or additionally,... Agent: Marshall, Gerstein & Borun LLP

20100248349 - Animal blood cell measuring apparatus: An animal blood cell measuring apparatus comprising: a specimen preparation section for preparing a measurement specimen from blood of an animal; a characteristic information obtaining section for obtaining characteristic information indicating a characteristic of the measurement specimen, from the measurement specimen prepared by the specimen preparation section; and a controller... Agent: Brinks Hofer Gilson & Lione

20100248348 - Target nucleic acid measuring apparatus: The present invention relates to calculation of an amount equivalent to an initial template amount in a test sample by fitting a theoretical expression to an amount equivalent to an amplification amount of target nucleic acid for each thermal cycle number, wherein the theoretical expression includes an environmental coefficient as... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100248350 - Micromethod and device for the rapid detection, enumeration and identification of microorganisms: The present invention provides a device such as a medical device for the rapid detection, enumeration and identification of microorganisms. It is based on the production and accumulation of absorbent or fluorescent molecules during reactions between artificial substrates and enzymes in micro-channels of a sampling-detecting unit of the device. Enzymes... Agent: Thompson Hine L.L.P. Intellectual Property Group

20100248351 - Chip for optical analysis: The present invention relates to a chip for optical analysis. In particular, the present invention relates to an optical sensor handling a liquid sample, which is a chip for analysis that can be used for selectively measuring a biologically-relevant substance or a chemical substance such as an environmental pollutant or... Agent: Workman Nydegger 1000 Eagle Gate Tower

20100248352 - Sensor for biological detection: Provided is a sensor for biological detection. The sensor for biological detection includes: a sensing unit including a light generator, an optical coupler, and an optical detector, the optical coupler dividing light incident from the light generator to project divided lights into a bio chip and a reference unit, respectively,... Agent: Ladas & Parry LLP

20100248353 - In-situ system for aerobic heat treatment of biodegradable organic waste: The proposed invention is an in-situ system for aerobic heat treatment of biodegradable organic waste, comprising a bioreactor made up of a dish-shaped decomposition chamber, said decomposition chamber being closed and having: a lid at the top, via which an air extraction device is connected, said device enabling fresh air... Agent: Baker & Mckenzie LLP

20100248354 - Membrane vesicle fission system: A membrane vesicle fission system is disclosed. The membrane vesicle fission system includes: a membrane vesicle having a lipid bi-layer membrane including a cationic lipid; and a unit which applies, to the membrane vesicle, an anionic material having a hydrophobic group.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100248356 - Htert gene expression regulatory gene: Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase... Agent: Pearne & Gordon LLP

20100248355 - Methods for generating high titer helper-free preparations of released recombinant aav vectors: This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector... Agent: Morrison & Foerster LLP

20100248359 - Anti-glypican 3 antibody: An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the... Agent: Fish & Richardson PC

20100248358 - Cell separating apparatus and cell separating method: A cancer cell separating apparatus includes: a flow channel including an antibody fixation area having antibodies which bind specifically to cancer cells fixed thereon, wherein the cancer cells and non-cancer cells are separated using a difference in velocity of movement between the cancer cells and the non-cancer cells in cell... Agent: Harness, Dickey & Pierce, P.L.C

20100248357 - Nematode fatty acid desaturase-like sequences: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid... Agent: Fish & Richardson PC

20100248360 - Human t2r51 taste receptor nucleic acid sequences and polypeptides: Newly identified mammalian taste-cell-specific G Protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are believed to be involved in bitter taste sensation, and the genes encoding the same, are described, along with methods for isolating such genes and for isolating and... Agent: Hunton & Williams LLP Intellectual Property Department

20100248361 - Platelet production methods: The present invention provides platelet production methods. The method comprises the steps of providing a cellular material and culturing the cellular material, wherein platelets are produced. The culturing may be performed on 2D or 3D cell support structure or in suspension culture. In some embodiments, all or a part of... Agent: Calfee Halter & Griswold, LLP

20100248362 - Apparatus and methods for sorting particles: A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation.... Agent: Inguran LLC

20100248363 - Matrices and media for storage and stabilization of biomolecules: The present invention provides compositions useful for biomolecule storage comprising a water soluble inorganic compound, a stabilizer, or a combination thereof. The present invention also provides methods of using the compositions of the invention to store biomolecules in the dry state and in solution, as well as sample carriers and... Agent: Cooley LLP Attn: Patent Group

20100248365 - Ganglioside biosynthesis modulators: Provided herein are ganglioside synthesis inhibitors, including modulators of ganglioside glycosylation.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100248364 - Sense ologonucleotide capable of controlling the expression of inos and composition comprising the same: The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is... Agent: Sughrue Mion, PLLC

20100248366 - Synthetic surfaces for differentiating stem cells into cardiomyocytes: Synthetic surfaces capable of supporting culture of eukaryotic cells including stem cells and undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a polypeptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition... Agent: Geron Corporation Attn. David J. Earp

20100248367 - Method for isolation of inner cell mass and method of preparation of embryonic stem cell lines using inner cell mass isolated by the same: A method for isolation of an inner cell mass and a method for preparation of embryonic stem cell lines using the inner cell mass isolated by the same. A blastocyst being free from a zona pellucida removed therefrom is placed on a feeder cell, and a micro cover glass is... Agent: Chang Hyun Kim

20100248368 - Biomaterial: A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a... Agent: Senniger Powers LLP

20100248369 - Renal-function-ameliorating agent: A renal function-ameliorating agent and a serum creatinine-lowering agent, each comprising as an active ingredient a culture of a bacterium belonging to the genus Bacillus, are disclosed. The bacterium belonging to the genus Bacillus is preferably Bacillus subtilis, and more preferably Bacillus subtilis C-3102 (FERM BP-1096). The renal function-ameliorating agent... Agent: Osha Liang L.L.P.

20100248370 - Method and apparatus for tissue transfer: A handheld tool is disclosed which may be used to transfer a plurality of plant tissue explants from a first container to a second container. The handheld tool may include a disposable tip member which couples the plurality of plant tissue explants through use of negative pressure. An automated system... Agent: Baker & Daniels LLP- Dow Agrosciences

20100248371 - Methods and compositions for modulating rad51 and homologous recombination: The present invention concerns methods and compositions involving inhibitors and enhancers of RAD51, a protein involved in homologous recombination. In some embodiments, the present invention concerns methods for stimulating homologous recombination, which has a number of significant research and clinical applications. In certain other embodiments, there are methods for protecting... Agent: Fulbright & Jaworski L.L.P.

20100248372 - Composition and method for modulating plant transformation: A plant culture medium composition for modulating plant transformation events, comprising a plant culture medium and an effective amount of at least one compound having a chloride component intermixed thereinto. In one embodiment, the at least one chloride-containing compound is selected from the group comprising: NaCl, MgCl2, and KCl. Another... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20100248373 - Method for introducing foreign substance into cell having cell wall: Disclosed is a method for introducing a foreign substance (3) into a cell (1) having a cell wall. The method comprises the steps of: providing a carbon nanotube (2) carrying at least one enzyme capable of decomposing a cell wall; supplying the carbon nanotube (2) and the foreign substance (3)... Agent: Turocy & Watson, LLP

  
09/23/2010 > patent applications in patent subcategories. class, title,number

20100240021 - Method and apparatus for automated staining of biological materials: Various embodiments of the present invention provide methods and systems for optimally staining biological samples for analysis. In one embodiment, images of a sample are recorded before and after the application of a staining reagent and a decolorization reagent. A difference image is then generated based at least in part... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100240020 - Method of making biological components for devices by forced environmental adaptation: An improved method for the design and development of high performance biologically-derived components for use in hybrid devices. The biologically-derived component is used in hybrid constructs that may be nanostructures, given the small size of the biological parts. Force adaptation is used to bring an organism from which the biologically-derived... Agent: Gallagher & Kennedy, P. A.

20100240022 - Reagent preparation and valving design for liquid testing: The technology described in this disclosure is a combination of controlled and precise ‘reagent delivery’ integrated together with controlled liquid flow through a sample processing device used for generating a desired chemical or biological reaction.... Agent: Morriss Obryant Compagni, P.C.

20100240024 - Assays and kits for determining hiv-1 tropism: The present invention relates to assays and kits for determining tropism of HIV-1 for a chemokine receptor in a test sample obtained from a subject.... Agent: Vysis, Inc Patent Department

20100240025 - Bacteriophage with enhanced lytic activity: This invention encompasses an isolated Bacillus phage AP50 that has one or more nucleotide substitutions in the phage genome, whereby the one or more nucleotide substitutions increase lytic activity of the phage. In addition, the invention encompasses proteins expressed by the phages, compositions containing the proteins and/or the phage as... Agent: Morgan Lewis & Bockius LLP

20100240026 - Kit and method for detecting bovine viral diarrhea virus in tissue samples: The present invention relates to the method for treatment of tissue samples with proteolytic/histolytic additive collagenase or other similar protease prior to testing with an antigen capture immunoassay to identify cattle infected with Bovine Viral Diarrhea Virus (BVDV). The use of collagenase or other similar protease in antigen extraction step... Agent: Rankin, Hill & Clark LLP

20100240023 - Method for extracting deoxyribonucleic acids (dna) from microorganisms possibly present in a blood sample: The present invention relates to a method for extracting DNA from microorganisms possibly present in a blood sample, comprising the following steps: i) filtration of a blood sample through a filtration membrane, the pores of which have a diameter ranging from 0.01 μm to 50 μm, in particular from 0.1... Agent: Arent Fox LLP

20100240027 - Surrogate markers for viral infections and other inflammatory responses: Compositions and methods for the detection, diagnosis and treatment of BVDV and other viruses are provided.... Agent: Dann, Dorfman, Herrell & Skillman

20100240030 - new method for qualitative and quantitative detection of short nucleic acid sequences of about 8-50 nucleotides in length: The present invention concerns a new analytical method for qualitative and quantitative detection of short nucleic acid sequences, preferably a DNA oligonucleotide or a modified DNA oligonucleotide such as antisense oligonucleotides or fragmented nucleic acid sequences of about 8-50 nucleotides in length. The invention relates to the introduction of modified... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100240048 - Biological sample reaction chip, biological sample charging device, biological sample quantifying device, and biological sample reaction method: A biological sample reaction chip includes, a first path having a first width, a second path having a second width wider than the first width wherein the first path and the second path being connected, a first opening through which a first liquid is introduced into the first path, and... Agent: Harness, Dickey & Pierce, P.L.C

20100240029 - Cholesterol-regulating complex of sirt1 and lxr and methods of use: A cholesterol-regulating complex of SIRT1 and LXR and methods of use are disclosed. SIRT1 forms a complex with LXR bound to an LXR element. Methods of forming the complex, identifying an agent that modulates formation of the complex, increasing the ratio of cholesterol bound to high density lipoprotein (HDL) to... Agent: Proteus Patent Practice LLC

20100240033 - Constitutively active mutants of the prolactin receptor: The invention relates to constitutively active mutants of the prolactin receptor (PRLR), wherein an Ile residue at position 76 or at position 146 of the mature form of said receptor has been substituted by another amino acid residue. The invention also provides methods useful for the diagnosis, prognosis, or treatment... Agent: Morgan Lewis & Bockius LLP

20100240060 - Detection and diagnosis of smoking related cancers: Gene probes for specific regions of chromosome 3 (3p21.3) and chromosome 10 (10q22) have been found to be tools for the diagnosis and prognosis of smoking related cancers such as non-small cell lung cancer (NSCLC). For example, these probes can be used with fluorescence in situ hybridization (FISH), and used... Agent: Fulbright & Jaworski L.L.P.

20100240051 - Device and method for preparing and performing multiple polymerase chain reactions: The present invention relates to methods, kits and devices with multiple open reaction chambers having multiple pre-deposited primer compositions, and a basic sample loading mechanism that utilizes an immiscible companion fluid for preparing and performing multiple Polymerase Chain Reactions... Agent: Venable LLP

20100240064 - Differential enzymatic fragmentation: The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.... Agent: Townsend And Townsend And Crew, LLP

20100240039 - Fhl1 mutations associated with novel x-linked muscular myopathies: Four and a Half LIM domains protein 1 (FHL-1) mutations at positions 128 or 224 that are associated with X-linked muscular myopathy, methods of screening subjects to identify those susceptible to muscular myopathy including muscular dystrophy and cardiomyopathy and kits.... Agent: Winston & Strawn LLP Patent Department

20100240034 - Gene defects and mutant alk kinase in human solid tumors: In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100240054 - Identification and isolation of fetal cells and nucleic acid: The present invention provides methods, antibodies and kits useful for detecting the presence of a fetal cell and/or fetal nucleic acids in a biological sample obtained from a maternal host. It also provides methods and kits for isolating fetal nucleic acid from maternal cervical mucus samples, and for testing or... Agent: Cooley LLP Attn: Patent Group

20100240037 - Identification of markers in esophageal cancer, colon cancer, head and neck cancer, and melanoma: Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such... Agent: Hirshman Law, LLC

20100240059 - Maize event dp-098140-6 and compositions and mehtods for the identification and/or detection thereof: Compositions and methods related to transgenic glyphosate/ALS inhibitor-tolerant maize plants are provided. Specifically, the present invention provides maize plants having a DP-098140-6 event which imparts tolerance to glyphosate and at least one ALS-inhibiting herbicide. The maize plant harboring the DP-098140-6 event at the recited chromosomal location comprises genomic/transgene junctions having... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20100240055 - Method and system for analyzing a blood sample: Methods, systems, and computer program products for the analysis of a blood sample are disclosed. One embodiment is a method of detecting and enumerating hard-to-ghost cells in a blood sample. Another embodiments is a method of analyzing reticulocytes in a blood sample. Methods of using blood count parameters are also... Agent: Sterne Kessler Goldstein & Fox, P.l.l.c.

20100240032 - Method for determining the allergic potential of a compound: t

20100240062 - Method for preparing and analyzing cells having chromosomal abnormalities: The present invention provides methods for preparing cells with highly condensed chromosomes, such as sperm, and methods for detecting and quantifying specific cellular target molecules in intact cells. Specifically, methods are provided for detecting chromosomes and chromosomal abnormalities, including aneuploidy, in intact cells using fluorescence in situ hybridization of cells... Agent: Law Offices Of Ronald M Anderson

20100240040 - Method for screening for selective modulator of the nf-kb pathway activation: The invention relates to methods for screening for selective modulator of NF-κB pathway activation. The invention concerns methods for primary screening molecules that potentially modulate (activate or inhibit) the NF-κB pathway activation by identifying and selecting molecules modulate the interaction of NEMO with other proteins. The invention also concerns methods... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100240042 - Method of detecting methylated cytosine: e

20100240031 - Method of predicting metastatic potential prognosis or overall survival of cancer patients: A method of predicting metastatic potential, prognosis or overall survival of cancer patients is provided. The method utilizes reliable markers, HIF-1α, TWIST or Snail, to predict the probability of the metastatic potential, prognosis situation or overall survival of cancer patients. Moreover, the method provided by the present invention can reach... Agent: Hogan Lovells US LLP

20100240038 - Method of screening a drug such as insulin secretagogue: The screening method of the present invention is useful for screening drugs such as insulin secretagogues having an insulin secretagogue activity with minimized side effects (hypoglycemia induction, etc.). The transformant in which a polynucleotide encoding the fusion protein used for the screening method is introduced, the screening kit comprising the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100240028 - Method to improve quality of microarrays by controlling evaporation: Methods and compositions described here minimize loss due to evaporation during the process of preparing gel-element microarrays; maintain uniform gel density; minimize irregular spontaneous polymerization; and provide conditions to obtain reproducible and consistent gel-array elements. The materials and methods described herein present techniques for restoring the original composition of the... Agent: Barnes & Thornburg LLP

20100240057 - Methods and compositions for the diagnosis and treatment of chronic myeloid leukemia and acute lymphoblastic leukemia: Compositions and methods for the identification, prognosis, classification, treatment, and diagnosis of leukemia or a genetic predisposition to leukemia are provided. The present invention is based on the discovery of various genomic abnormalities of the IKZFl gene which are shown herein to be associated with acute lymphoblastic leukemia (ALL), more... Agent: Alston And Bird LLP St. Jude Children's Research Hospital

20100240047 - Methods and compounds for detection of molecular targets: The present invention relates to methods and compounds for detection of molecular targets, such as biological or chemical molecules, or molecular structures, in samples using a host of experimental schemes for detecting and visualizing such targets, e.g. immunohistochemistry (IHC), in situ hybridization (ISH), ELISA, Southern, Northern, and Western blotting, etc.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100240050 - Methods and products for in vivo enzyme profiling: The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also... Agent: Wolf Greenfield & Sacks, P.C.

20100240046 - Methods and systems for identifying pcr primers specific to one or more target genomes: Methods and systems for identifying a primer pair for polymerase chain reaction specific to one or more target genomes. Methods and systems of the present disclosure can be used to identify primers that can distinguish between target genomes and closely related non-target genomes.... Agent: Siemens Corporation Intellectual Property Department

20100240056 - Methods and systems for screening species-specific insecticidal candidates: Disclosed are methods and systems for identifying compounds that act to modulate insect growth and/or development in a species-specific manner. Such systems and methods may provide for the identification of species-specific insecticides. The methods and systems of the invention may include at least one an isolated nucleic acid molecule that... Agent: Kilpatrick Stockton LLP

20100240049 - Methods of detecting cervical cancer: Methods of detecting cervical dysplasia, such as cervical dysplasia likely to progress to carcinoma in a sample of human cervical cells, are provided. Methods of detecting changes in expression of one or more microRNAs or mRNAs associated with cervical dysplasia or cervical cancer are also provided. Compositions and kits are... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100240043 - Methods of using genetic variants to diagnose and predict inflammatory bowel disease: The present invention relates to methods of diagnosing susceptibility to Inflammatory Bowel Disease and subtypes of Inflammatory Bowel Disease. In one embodiment, the present invention provides a method of diagnosing susceptibility to Inflammatory Bowel Disease by determining the presence of one or more risk variants at the DR3 locus, GATA3... Agent: Davis Wright Tremaine LLP/los Angeles

20100240044 - Micro chip: Instant invention is about a micro chip comprising plurality of layers of LTCC wherein a reaction chamber is formed in plurality of top layers to load samples. A heater embedded in at least one of the layers below the reaction chamber and a temperature sensor is embedded in at least... Agent: Fenwick & West LLP

20100240041 - Microfluidic device for trapping single cell: It is to provide a microfluidic device which separates and captures with high efficiency a large amount of cells in a sample at one-cell level without damaging the cells by utilizing a microfabrication technology. The device sequentially comprises: an upper substrate consisting of a plastic plate provided with a groove... Agent: King & Spalding

20100240058 - Microrna antisense pnas, compositions comprising the same, and methods for using and evaluating the same: Disclosed are a microRNA antisense PNA capable of inhibiting the activity or function of microRNA, a composition for inhibiting the activity or function of microRNA containing the same, a method for inhibiting the activity or function of microRNA using the same, and a method for evaluating the effectiveness thereof.... Agent: The Webb Law Firm, P.C.

20100240035 - Multigene prognostic assay for lung cancer: The present invention provides methods for providing a prognosis for lung adenocarcinoma, using a panel of eight molecular markers that are differentially expressed in lung adenocarcinoma.... Agent: Townsend And Townsend And Crew, LLP

20100240036 - Nucleic acid probes and methods for detecting plasmodium parasites: This invention relates to novel nucleic acid-based probes and methods for detecting Plasmodium parasites in biological samples as well as detecting different Plasmodium parasites selectively from one another.... Agent: Kevin Farrell Pierce Atwood

20100240045 - Nucleotide compositions and uses thereof: The present invention relates to preparation of nucleotide compositions and uses thereof for conducting nucleic acid analyses. The compositions and methods embodied in the present invention are particularly useful for nucleic acid analyses that require high-resolution detection of labeled nucleotides or labeled nucleic acid targets.... Agent: Pacific Biosciences Of California, Inc.

20100240052 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20100240053 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20100240061 - Soybean polymorphisms and methods of genotyping: Polymorphic soybean DNA loci useful for genotyping between at least two varieties of soybean. Sequences of the loci are useful for designing primers and probe oligonucleotides for detecting polymorphisms in soybean DNA. Polymorphisms are useful for genotyping applications in soybean. The polymorphic markers are useful to establish marker/trait associations, e.g.... Agent: Thompson Coburn, LLP

20100240063 - Systems and methods for detecting multiple optical signals: To minimize cross talk in systems and methods for detecting two or more different optical signals emitted from each of a plurality of reaction receptacles, an excitation signal associated with each of the optical signals has a known excitation frequency, and any detected signal having a frequency that is inconsistent... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100240065 - Prolyl hydroxylase compositions and methods of use thereof: The invention provides methods and compositions for making and using novel HIF-specific prolyl hydroxylase (HPH) enzymes from rhesus monkeys.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100240066 - Compounds and methods for modulating cadherin-mediated processes: Peptides comprising a cadherin cell adhesion recognition (CAR) sequence, and compositions comprising such peptides, are provided. Methods of using such peptides for modulating cadherin-mediated processes in a variety of therapeutic contexts are also provided. Methods are also provided for identifying compounds that are capable of modulating cadherin-mediated processes.... Agent: Seed Intellectual Property Law Group PLLC

20100240071 - Assay for detection of transient intracellular ca2+: This invention relates to a simple end point assay for detection of transient intracellular Ca2+ with broad applicability to many Ca2+channel proteins comprising, Generation of expression constructs for the fusion proteins having the Ca2+/calmodulin dependent protein kinase II (CaMKII) phosphorylation sites of NR2A or NR2B subunits of N-methyl-D-aspartate receptor (NMDAR)... Agent: The Webb Law Firm, P.C.

20100240072 - Cancer imaging and treatment: A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me) Arg within the cyclic moiety, wherein B is... Agent: Mallinckrodt Inc.

20100240073 - Detection of false results in assays: Methods and reagents are disclosed for detecting a false result in an assay for determining a concentration of an analyte in a whole blood sample suspected of containing the analyte. The method comprises determining by means of the assay a concentration of the analyte utilizing a hemolyzed portion of the... Agent: Dade Behring Inc. Law And Patents

20100240074 - Set of yeast cells, method of identifying target candidate molecule, method of analyzing action mechanism and screening method: Provided is a set of yeast gene knockout strains whose drug sensitivity is significantly improved. A set of yeast cells of the invention is a set of yeast cells comprising two or more types of yeast cells, wherein at least one mutually different gene has been deleted or mutated in... Agent: Marshall, Gerstein & Borun LLP

20100240075 - Complement factor h-based assays for serum bactericidal activity against neisseria meningitidis: Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fHBp) are provided, as well as non-human animal models of Neisserial infection.... Agent: Bozicevic, Field & Francis LLP

20100240067 - Apparatus and method for assaying coagulation in fluid samples: This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade.... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20100240068 - Marker panel for colorectal cancer: The present invention relates to a method for assessing colorectal cancer (CRC) in vitro including measuring in a sample the concentration and/or activity of a seprase polypeptide and/or fragments thereof and of either anti-p53 and/or osteopontin and/or ferritin, of optionally one or more other marker of CRC, and using the... Agent: Roche Diagnostics Operations Inc.

20100240069 - Drug discovery assay for modulators of hif-prolyl hydroxylase activity: The present invention relates to a high throughput assay for determining HIF 1α prolyl hydroxylation.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100240070 - Nonseparation assay methods using peroxide generating enzymes: Nonseparation assay methods using peroxide generating enzymes in combination with a solid support for analyte detection are disclosed. The present assay methods provide a high degree of sensitivity, are simple and efficient to perform, and are excellent tools for diagnostic and high through-put screening applications.... Agent: Michael C. Schiffer - Legal Dept. Beckman Coulter, Inc.

20100240076 - Immunoassay involving mutant antigens to reduce unspecific binding: A method for a quantitative in vitro analysis to diagnose, to categorise, to predict and/or to monitor the progression of a condition comprising the following steps: a) Obtaining a sample suspected of containing anti-A-antibodies from a subject to be analysed, b) Providing native and mutant antigen A, c) Contacting the... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100240077 - Methods of assessing crohn's disease patient phenotype by i2 serologic response: The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a... Agent: Townsend And Townsend And Crew, LLP

20100240078 - Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes: The present invention relates to methods and compositions for diagnosing SIRS, sepsis, severe sepsis, septic shock, or MODS in a subject, or assigning a prognostic risk for one or more clinical outcomes for a subject suffering from SIRS, sepsis, severe sepsis, septic shock, or MODS, the method comprising performing an... Agent: Wilson, Sonsini, Goodrich & Rosati

20100240079 - Glucose tolerace test device: A glucose tolerance test device comprising: a test zone having a means to receive at least first and second blood test samples spaced apart by a predetermined time interval; a timer to measure such a time interval, and for example to measure elapsed time after collection of a said first... Agent: Jacobson Holman PLLC

20100240080 - Kinase and phosphatase assays: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the... Agent: Life Technologies Corporation C/o Intellevate

20100240081 - Seprase as a marker for cancer: The present invention relates to a method aiding in the assessment of cancer. It discloses the use of the human fibroblast activation protein (FAP/seprase) as a universal marker of different cancer types. Seprase aids in the assessment of pulmonary or lung cancer (LC) or of colon cancer, e.g., of non-small... Agent: Roche Diagnostics Operations Inc.

20100240082 - Methods for detecting and measuring polysaccharide-hydrolyzing enzymes: Methods are disclosed for detecting and measuring polysaccharide-hydrolyzing enzyme activity or concentration by partial hydrolysis using a pre-determined, yet short, incubation time and a pre-determined temperature. The resulting reaction mixture has unique chemical (i.e., reaction products) and physical (i.e., viscosity) properties that can be used to detect or measure the... Agent: Syngenta Biotechnology, Inc. Patent Department

20100240083 - Method for the detection of the in-vivo activity of neurotrypsin, use of the method and use of the c-terminal, 22-kda fragment of agrin as biomarker in diagnosis and monitoring of neurotrypsin-related disturbances: Method for the detection of the in-vivo activity of neurotrypsin wherein the amount of the 22-kDa-fragment of agrin is measured in a sample taken from a patient and the measured amount of the 22-kDa-fragment of agrin in the sample is used to calculate the activity of neurotrypsin, use of the... Agent: Rankin, Hill & Clark LLP

20100240084 - Use of the protien maba (fabg1) of mycobacterium tuberculosis for designing and screening antibiotics: The protein MabA, also named protein FabG1, which is recombinant in a purified form, or the recombinant proteins derived from the protein MabA by mutation of at least one amino acid. The uses of proteins MabA, or recombinant proteins derived from protein MabA by mutation of at lease one amino... Agent: Young & Thompson

20100240085 - Conjugate molecules: The present invention relates to compounds which are conjugates of two or more moieties capable of serving as substrates of an enzyme with peroxidase activity and one or more labels. The conjugate molecules of the invention are useful for detection of molecular targets, e.g. biological or chemical molecules, molecular structures,... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100240086 - Biochip assembly and assay method thereof: e

20100240089 - Lead isotope tracer method to determine bone mineral turnover: A method of determining bone mineral turnover in bone of a subject involves determining isotopic ratio of one lead isotope (preferably 206Pb) to other lead isotopes in a biological material (e.g. blood or urine) of a subject taking dietary calcium, comparing the isotopic ratio determined to a control isotopic ratio... Agent: Ira S. Dorman

20100240087 - Method and system for the automatic detection and diagnosis of a cancer stem cell: A method for predetermining whether a cancer has a probability to become metastatic or recurrent, having the steps of: obtaining a sample cell population; assaying the sample cell population; detecting the rate of change of the sample cell population's pH over time; and comparing the pH change versus a predetermined... Agent: Ohlandt, Greeley, Ruggiero & Perle, LLP

20100240090 - Methods and platforms for drug discovery: The present invention involves methods for identifying an agent that corrects a phenotype associated with a health condition or a predisposition for a health condition. The invention also involves methods for identifying a diagnostic cellular phenotype, determining the risk of a health condition in a subject, methods for reducing the... Agent: Wilson, Sonsini, Goodrich & Rosati

20100240088 - Peptide markers for diagnosis of angiogenesis: The present invention relates to a method for detecting physiological or pathological blood vessel formation, preferably glioma activity, comprising determining the expression level of colligin 2 in blood, cerebrospinal fluid or tissue vasculature. The invention further relates to the use of a method for detecting physiological or pathological blood vessel... Agent: Swanson & Bratschun, L.L.C.

20100240091 - Biochemical test for confirming the presence of l. monocytogenes: The invention relates to a biochemical test for confirming the presence of L. monocytogenes, characterized in that it comprises at least one phosphatidylinositol phospholipase C (PI-PLC) substrate and at least one alpha-mannosidase substrate.... Agent: Oliff & Berridge, PLC

20100240092 - Detection method and detection apparatus: Provided is a method of adjusting detection sensitivity in detecting a sample in a channel. A detection method of optically detecting a sample includes: forming a multilayer flow, in which at least one of layers of the multilayer flow contains the sample; introducing light into at least one of layers... Agent: Canon U.s.a. Inc. Intellectual Property Division

20100240093 - Isolated staphylococcus pseudolugdunensis: Disclosed is an isolated strain of a previously unknown Staphylococcus, Staphylococcus pseudolugdunensis. Also disclosed are the sequences of the S. pseudolugdunensis tuf gene and 16s rRNA and methods for distinguishing S. pseudolugdunensis from other staphylococcal species.... Agent: Bradley Arant Boult Cummings LLP Intellectual Property Department

20100240094 - Fermenter for generating biogas from pumpable organic material: The invention relates to a fermenter for generating biogas from pumpable organic material with a low content of organic dry matter (oTS), comprising at least one inlet for the pumpable organic material, at least one fixed bed reactor for the pumpable organic material with at least one primary and one... Agent: Occhiuti Rohlicek & Tsao, LLP

20100240095 - Polypeptides having cellobiohydrolase ii activity and polynuleotides encoding same: The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes, Inc.

20100240097 - Mammalian expression vector with a highly efficient secretory signal sequence: The present invention relates to a mammalian cell based expression and secretion system and the expression and secretion of recombinant proteins by using secretory signal peptides. The present invention also relates to an expression cassette useful for the secretion of a heterologous gene from a mammalian cell, in particular a... Agent: Hoffmann & Baron, LLP

20100240096 - Novel hemopoietin receptor protein, nr10: The inventors succeeded in isolating a novel hemopoietin receptor gene (NR10) using a sequence predicted from the extracted motif conserved in the amino acid sequences of known hemopoietin receptors. It was expected that two forms of NR10 exists, a transmembrane type and soluble form. Expression of the former type was... Agent: Fish & Richardson PC

20100240098 - Process for producing mature recombinant mite group i allergen: The present invention relates to a process for producing mature recombinant Mite Group I allergen comprising the steps of a) providing an allergen expression system in the form of a host cell selected from the group of yeasts containing a vector comprising cDNA encoding pro-allergen, b) cultivating the allergen expression... Agent: Birch Stewart Kolasch & Birch

20100240100 - Human antibodies that have mn binding and cell adhesion-neutralizing activity: The invention is composed of monoclonal human MN antibodies or MN antibody fragments that target the GEEDLP repeat within the proteoglycan domain. The proteoglycan domain of the MN cell surface protein contains four of these identical GEEDLP repeats. Binding to the desired epitope is verified by competition ELISA, where ELISA... Agent: Edwards Angell Palmer & Dodge LLP

20100240099 - Rbsa from k. lactis expression, secretion and purification of recombinant bovine serum albumin (rbsa) from k. lactis and uses thereof: A recombinant BSA (rBSA) that (a) substantially lacks deoxyribonuclease activity as determined by incubating rBSA with linear DNA overnight and gel electrophoresis, (b) lacks animal viruses associated with animal-derived cell growth supplements; and (c) is capable of stabilizing DNA proteins is provided. Methods for making the rBSA and using it... Agent: Harriet M. Strimpel, D. Phil.

20100240101 - Parallel proximity ligation event analysis: The present invention describes compositions and methods showing that the spatial proximity of intracellular components may be related to their ability to cooperate in intracellular biochemical reactions. In some embodiments, the present invention contemplates a variety of nucleic acid barcoded binding partners capable of determining the spatial proximity of intracellular... Agent: Medlen & Carroll, LLP

20100240102 - Methods and compositions for multiple displacement amplification of nucleic acids: Disclosed are methods for multiple displacement amplification of a nucleic acid sequence in a sample. The nucleic acid is contacted with a reaction mixture that includes a set of oligonucleotide primers and a plurality of polymerase enzymes. The reaction mixture is subjected to conditions under which the nucleic acid sequence... Agent: Casimir Jones, S.c.

20100240103 - Oligonucleotides labeled with a plurality of fluorophores: An embodiment of the invention discloses new methods for designing labeled nucleic acid probes and primers by labeling oligonucleotides with a plurality of spectrally identical or similar dyes and optionally with one or more quencher dyes. Oligonucleotides labeled in accordance with some embodiments of the invention exhibit a detectable increase... Agent: Wilson, Sonsini, Goodrich & Rosati

20100240104 - Conversion of knot rejects from chemical pulping: Knot rejects from chemical pulping processes are subjected to acid hydrolysis or an enzymatic hydrolysis treatment. The resultant hydrolysate is enriched with glucose, representing a value-added raw material for products using hexoses. The residue, separated from the said hydrolysate after the acid hydrolysis or enzyme treatment, consists of mainly knots... Agent: Ogilvy Renault LLP

20100240105 - Method for producing glucosamine by culturing microorganism with low-cost medium: A method for producing glucosamine with microorganism comprises of fermenting with a microorganism selected from the group consisting of Monascus pilosus and Aspergillus sp. in a novel low-cost medium, thereby enable it to produce glucosamine; wherein said medium is consisted of commercial Taiwan sugar, soy beam, rice bran and the... Agent: Schmeiser Olsen & Watts

20100240106 - Mutant enzymes: This invention relates to mutant enzymes with enhanced properties and processes for oxidation of organic compound substrates using such enzymes.... Agent: Fulbright & Jaworski, LLP

20100240107 - Process for producing optically active 2-alkyl-1,1,3-trialkoxycarbonylpropane: A process for producing an optically active 2-alkyl-1,1,3-trialkoxycarbonylpropane (2), comprising a step of asymmetric hydrolysis of 2-alkyl-1,1,3-trialokoxycarbonylpropane (1) by using an enzyme capable of selectively hydrolyzing an ester moiety of either one enantiomer of 2-alkyl-1,1,3-trialkoxycarbonylpropane (1), or by using a culture of a microorganism capable of producing the enzyme or... Agent: Panitch Schwarze Belisario & Nadel LLP

20100240108 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20100240109 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20100240110 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20100240111 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20100240112 - Process for preparing a sugar product: The invention relates to a method for producing sugars, such as glucose, by fractionating lignocellulose-containing biomass. The sugar product thus obtained is useful for the manufacture of bioethanol and other chemicals.... Agent: Alston & Bird LLP

20100240113 - method of degumming jute fibres with complex enzyme (1): A method of degumming jute fibres with complex enzyme, wherein said complex enzyme comprises pectinase and laccase, wherein comprising the steps of: a. soaking the jute fibres in the water solution of said complex enzyme made from pectinase and laccase, wherein the weight proportion of said complex enzyme water solution... Agent: Schwegman, Lundberg & Woessner, P.A.

20100240114 - Biomass production and processing and methods of use thereof: The present invention provides methods and systems for the production of macroalgae in a manner to provide a sustained, economical source of biomass that may be used in various end-use processes, including energy production. The invention provides specific combinations of macroalgae types, saltwater growth medium compositions, and open pond water... Agent: Womble Carlyle Sandridge & Rice, PLLC

20100240115 - Bioanalytical assay: A nanoparticle having a detectable feature and whose diameter is less than 200 nm, and which is coated with multiple specific binding reactants such that the affinity constant of the nanoparticle towards an analyte exceeds that of free binding reactant towards the analyte and/or the association rate constant between the... Agent: James C. Lydon

20100240116 - Lovastatin esterase enzyme immobilized on solid support, process for enzyme immobilization, use of immobilized enzyme, biocatalytic flow reactor and process for preparation and/or purification of simvastatin: The invention relates to the lovastatin esterase enzyme immobilized on a solid support insoluble in water, the enzyme being covalently bound to a solid support activated with an at least difunctional coupling reagent, the immobilized lovastatin esterase exhibiting at least 5 times higher the hydrolytic activity towards lovastatin and salts... Agent: Marsh, Fischmann & Breyfogle LLP

20100240117 - Three dimensional fabrication of biocompatible structures in anatomical shapes and dimensions for tissue engineering and organ replacement: Methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, biocompatible structures formed by three-dimensional fabrication, are described. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional... Agent: Wolf Greenfield & Sacks, P.C.

20100240118 - Cover removable device for culture vessel and culture apparatus: A lid removable device includes a first transferring mechanism transferring a culture vessel in a horizontal direction, a second transferring mechanism raising or lowering the culture vessel, a lid removable plate having an insertion region into which a vessel body of the culture vessel is inserted and a lid placing... Agent: Oliff & Berridge, PLC

20100240120 - Analytical strip and the manufacturing method thereof: An analytical strip including a substrate and a channel structure is disclosed. A substrate has a flat surface and the channel is formed on the flat surface according to a predetermined pattern. The surface of channel structure is not lower than the surface of the substrate. The channel has a... Agent: Sinorica, LLC

20100240119 - Microseparation structure and devices formed therewith: A microseparation structure is provided that includes a top surface defining a first chamber. A second chamber is provided that is in fluid communication with the first chamber and characterized by a volume less than the volume of the first chamber. At least one hole extends in fluid communication with... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20100240123 - Apparatus, system and method for purifying nucleic acids: Methods and devices for isolating nucleic acids from a mixture containing such nucleic acids and extraneous matter are provided. In one embodiment, the method of the invention comprises passing the mixture through a glass frit under conditions effective to separate the nucleic acids from the extraneous matter. In a more... Agent: Andrews Kurth LLP

20100240121 - Electrospun nanofibrous membrane assembly for use in capturing chemical and/or biological analytes: A membrane assembly adapted for use in capturing an analyte of interest, the membrane assembly comprising in one embodiment (a) an electrospun nanofibrous membrane, the electrospun nanofibrous membrane comprising a random mat of electrospun nanofibers, at least some of the electrospun nanofibers including one or more types of functional groups;... Agent: U.s. Army Soldier Systems Center Legal Office, A306

20100240122 - Spotter provided with spot pattern encryption function and detection device coping with spot pattern encryption: Plural probes spotted on a probe immobilization substrate are arranged such that the probes cannot be specified by a third party easily. When the plural probes are spotted on the probe immobilization substrate, a position where each probe is spotted is changed for each probe immobilization substrate to be prepared,... Agent: Fitzpatrick Cella Harper & Scinto

20100240124 - Sample processing device compression systems and methods: Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include a cover and compression... Agent: 3m Innovative Properties Company

20100240125 - Bone delivery conjugates and method of using same to target proteins to bone: A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z... Agent: Clark & Elbing LLP

20100240126 - Development of universal cancer drugs and vaccines: This invention generally relates to a design and method for developing novel anti-tumor/cancer drugs, vaccines and therapies, using microRNA (miRNA) and its shRNA homologues/derivatives. More particularly, the present invention relates to the use of a nucleic acid composition capable of expressing mir-302-like gene silencing effectors upon delivery into human cells... Agent: Birch Stewart Kolasch & Birch

20100240127 - Method of cryopreserving cells: A non-linear cooling cryopreservation method for improving cryopreservation protocols for cells that involves producing a simulation of cellular responses to a range of cooling parameters; determining optimal cooling parameters required to minimize cryoinjury to the cells using simulation of cellular responses and experimental results; and incorporating optimal parameters into the... Agent: Mccarthy Tetrault LLP

20100240128 - Modified gene silencing: This invention relates to methods of controlling gene expression or gene suppression in eukaryotic cells. One aspect of this invention includes modifying the degree of silencing of a target gene by use of a modified suppression element. Another aspect includes providing a eukaryotic cell having a desired phenotype resulting from... Agent: Monsanto Company

20100240129 - Transfer of molecules: The invention relates to liposomes, particularly, but not exclusively, to liposomes for introducing a molecule into a cell, and to processes for making and using liposomes.... Agent: Ballard Spahr LLP

20100240130 - Differentiation and enrichment of islet-like cells from human pluripotent stem cells: Methods for differentiating human pluripotent stem cells into islet-like cells are provided. In certain embodiments, the methods utilize sequential culturing of the human pluripotent stem cells with certain factors to produce islet-like cells. In certain embodiments, the population of cells produced by the methods is further enriched for islet-like cells.... Agent: Geron Corporation Attn. David J. Earp

20100240131 - Method of modifying the genome of gram-positive bacteria by means of a novel conditionally negative dominant marker gene: The invention relates to a novel method for modifying the genome of Gram-positive bacteria, to these bacteria and to novel vectors. The invention particularly relates to a method for modifying corynebacteria or brevibacteria with the aid of a novel marker gene which has a conditionally negatively dominant action in the... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100240132 - Highly efficient methods for reprogramming differentiated cells and for generating animals and embryonic stem cells from reprogrammed cells: The present invention relates generally to the field of somatic cell nuclear transfer (SCNT) and to the creation of cloned animals and cells. The disclosure relates to a method of cloning a mammal, obtaining pluripotent cells such as embryonic stem cells, or for reprogramming a mammalian cell using an oocyte... Agent: Hunton & Williams LLP Intellectual Property Department

20100240133 - Compositions and methods for transposon mutagenesis of human embryonic stem cells: PiggyBac transposons and transposases with enhanced transposition activity in cells are provided. Also provided are associated methods and kits for both introducing exogenous DNA inserts into the genomes of host cells as well as for the removal of the inserts from the host cell genomes. Cells obtained by use of... Agent: Thompson Coburn LLP

  
09/16/2010 > patent applications in patent subcategories. class, title,number

20100233669 - Bioburden-reducing antibiotic composition and method of use: An antibiotic composition is provided for use in decontaminating biological tissue, for example, graft tissues for transplantation or preparation for terminal sterilization. The antibiotic composition is a physiological solution includes a lantibiotic, such as nisin. The antibiotic solution is effective to substantially inhibit bacterial growth of at least one type... Agent: Sutherland Asbill & Brennan LLP

20100233670 - Frozen viable solid organs and method for freezing same: Disclosed is a method of freezing bulky biological material, comprising transferring heat out of said material to cool the material and increasing the rate of heat transfer during a time period when the inner portion of said biological material freezes and releases latent heat. This method allows prolonged ex-vivo preservation... Agent: The Nath Law Group

20100233673 - Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products: Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems; and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce... Agent: Ryan Kromholz & Manion, S.c.

20100233671 - Freeze-dried plasma formats for the trauma care field: Disclosed are freeze-dried plasma formats specifically designed for the trauma care field. Blood plasma is subjected to a glucose removal step, a protein fraction up-concentration step and addition of stabilizers prior to freeze-drying. Preferable stabilizers are glutamine dipeptides, glutamine and glycine. The glutamine based formulation is added direct to plasma... Agent: Remenick PLLC

20100233672 - Grape polyphenolics for platelet and bacterial control: Special extracts of grape berries and Goji berries can be prepared by exposing fruit juices or preparations to an insoluble binding resin which is then extracted with soluble polyvinylpyrollidone. Grape and Goji extracts made in this way can be used to inhibit or control platelet aggregation. Grape extract has exceptional... Agent: Stefan Kirchanski

20100233675 - Analyte manipulation and detection: Provided is a method for separating two or more analytes in a fluid, which method comprises: (a) binding each different analyte to a different functional particle in one or more binding zones, to produce two or more bound analytes; (b) allowing the bound analytes to move through a separating conduit... Agent: Knobbe Martens Olson & Bear LLP

20100233674 - Cells for detection and production of influenza and parainfluenza viruses: The invention provides cell lines that are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic cells with increased sensitivity to infection by influenza A, influenza B, or parainfluenza 3 viruses, or which are capable of enhanced productivity of infectious... Agent: Christine A. Lekutis Medlen & Carroll, LLP

20100233677 - Full genome sequences of human rhinovirus strains: Infection by human rhinovirus (HRV) causes upper and lower respiratory tract disease with varying degrees of virulence. The molecular basis of diversity was examined by completing the genome sequences for all known serotypes (n=99) as well as novel field samples. Superimposition of capsid crystal structure and optimal-energy RNA configurations established... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100233676 - High affinity fluorochrome binding peptides: The present invention contemplates strategies comprising small molecule, cell permeable probes that allow site-specific protein labeling for visualizing biological processes. In one embodiment, the present invention contemplates a series of short peptide sequences comprising high affinity binding (i.e., for example, subnanomolar affinity (0.53 nM) for indocyanine fluorochromes. In one embodiment,... Agent: Fish & Richardson PC

20100233678 - Tunable affinity ligands for the separation and detection of target substances: Conformationally tunable affinity ligands are rationally designed and selected for the ability to switch under operator-defined environmental conditions between or among structurally distinct states that have different affinities for a given target substance. Tunable affinity ligands are incorporated into reagents, separation media, assays, sensors, devices, kits and systems for sorting,... Agent: David M Mcconoughey

20100233709 - Abscription based molecular detection: The present invention provides methods for detecting biomarkers based on Abscription®, abortive transcription technology. Particularly, the present invention provides bisulfate free methods for detecting methylation of CpG islands from small samples of DNA. The methods are suitable for multiplexing and can be used to analyze multiple CpG islands from a... Agent: The Law Office Of Jane K. Babin Professional Corporation

20100233683 - Amplification of dna fragments: A method for detecting a nucleic acid molecule having a target sequence adjacent a 3′ terminus is provided. Also provided is a method for differentiating nucleic acid molecules having a target sequence adjacent a 3′ terminus from nucleic acid molecules in which the same sequence is embedded within the molecule.... Agent: Sughrue Mion, PLLC

20100233698 - Apparatus and method for multiplex analysis: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and... Agent: Wilson, Sonsini, Goodrich & Rosati

20100233721 - Apparatus and methods for detecting dna in biological samples: Apparatus and methods are described for detecting target DNA in a biological sample using capture probes and electrically-assisted hybridization. The reaction cell is formed with an attachment surface of aluminum oxide for better thermal and physical properties, and the aluminum oxide surface is coated with anti-DIG antibody to provide a... Agent: Buchanan, Ingersoll & Rooney PC

20100233720 - Biological reagents and methods to verify the efficiency of sample preparation and nucleic acid amplification and/or detection: This invention relates to reagent comprising: any one of cells, viral particles, organelles, parasites, cells comprising organelles, cells comprising viral particles, cells comprising parasites, cells comprising bacterial cells and any combination thereof, the cells, viral particles, organelles or parasites comprising at least one nucleic acid sequence serving as an internal... Agent: Knobbe Martens Olson & Bear LLP

20100233679 - Detection of truncation mutations in a large background of normal dna: Various methods and strategies are disclosed for detecting human tumors, and specifically colorectal tumors. Methods are also disclosed for detecting truncation mutations in a large background of wild-type DNA. And, methods for detecting AP mutations in a large background of wild-type DNA are also disclosed.... Agent: Fay Sharpe LLP

20100233694 - Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells: The invention encompasses methods and devices for diagnosing, theranosing, or prognosing a condition in a patient by enriching a sample in rare cells. The devices can be a microfluidic device comprising an array of obstacles and one or more binding moieties. The devices and methods can allow for enrichment of... Agent: Wilson, Sonsini, Goodrich & Rosati

20100233703 - Emx2 in cancer diagnosis and prognosis: The present invention provides methods for determining a prognosis of disease free or overall survival in a patient suffering from cancer. The methods generally involve determining a normalized expression level of an EMX2 gene product, which correlates with prognosis and likelihood of survival.... Agent: Townsend And Townsend And Crew, LLP

20100233682 - Fluid processing and volume determination system: A fluid processing system is described having at least two chambers. Each of said chambers is separated in a first and a second part by a flexible membrane, the first part, in use, comprising essentially a gas and the second part, in use comprising essentially a non-gaseous fluid, an inlet... Agent: Philips Intellectual Property & Standards

20100233692 - Fluorescently labeled fusion protein for assaying adenosine triphosphate: The object of the present invention is to provide a substance, which is easy to handle and enables the measurement of ATP with a high sensitivity regardless of the concentration of protein, and further a measuring method of ATP using the substance. Such object is solved with a fluorescence labelled... Agent: Jhk Law

20100233711 - Gene encoding labyrinthin, a marker for cancer: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the... Agent: Wilson, Sonsini, Goodrich & Rosati

20100233680 - Gene expression profiles and methods of use: The present invention relates to gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The invention also provides... Agent: Siemens Corporation Intellectual Property Department

20100233691 - Gene expression profiling for identification, monitoring and treatment of prostate cancer: A method is provided in various embodiments for determining a profile data set for a subject with prostate cancer or conditions related to prostate cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100233719 - Genetic markers for predicting disease and treatment outcome: The present invention provides for a method for identifying patients that are suitably treated by a therapy, such as a therapy involving administration of a fluoropyrimidine drug and/or a platinum drug. The method includes determining the expression level of at least one gene selected from a phospholipase 2 (PLA2) gene,... Agent: Foley & Lardner LLP

20100233707 - Materials and methods for predicting recurrence of non-small cell lung cancer: Disclosed herein is a DNA methylation-based test for determining the recurrence or non-recurrence of a lung cancer such as NSCLC after treatment. The assays involve the detection of methylation of the BAX gene promoter alone or in combination with other genes. The test is suitable for monitoring treatment of subjects... Agent: Foley & Lardner LLP

20100233687 - Method and system for temperature correction in thermal melt analysis: The present invention relates to methods and systems for temperature correction in thermal melt analysis. More specifically, embodiments of the invention relate to the correction of the melting temperature (Tm) observed for a sample nucleic acid due to the effect of the nucleic acid concentration.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100233681 - Method for cell based assays: Disclosed is a method for cell storage on beads and subsequent utilisation of cryogenically stored cells in cellular assays.... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100233684 - Method for determining inflammatory disease: It is an object of the present invention to provide a method for determining inflammatory diseases including myocardial infarction as a typical example, which involves identifying polymorphisms associated with myocardial infarction and using the gene polymorphisms, an oligonucleotide that can be used for the method, a kit for diagnosing inflammatory... Agent: Greenblum & Bernstein, P.L.C

20100233688 - Method for diagnosing spinal muscular atrophy: A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a universal multiplex PCR using the nucleotide as a template and... Agent: Pai Patent & Trademark Law Firm

20100233712 - Method for early detection of cancers: The invention includes methods for detecting the presence of a neoplastic condition by comparing a sample level of a BIF-1 to a reference, wherein a low level of BIF-1 in the sample correlates with the presence of a neoplastic condition. Another method involves determining the risk of relapse, tumor recurrence... Agent: Smith Hopen, Pa

20100233697 - Method for standarizing surface binding of a nucleic acid sample for sequencing analysis: Methods are described which enable nucleic acid sample standardization prior to anchoring to a surface, especially useful in single molecule nucleic acid sequencing applications when sample is limiting or unamplified.... Agent: Lando & Anastasi, LLP

20100233713 - Method for treating a solution in order to destroy any ribonucleic acid after amplification: t

20100233715 - Method of nucleic acid amplification and measuring reagent and reagent kit therefor: The object of the present invention is to provide a method that allows stable amplification of an internal standard material while maintaining an accurate assay value for a target nucleic acid in a nucleic acid detection system involving the use of an internal standard material and a reagent kit used... Agent: Pillsbury Winthrop Shaw Pittman LLP

20100233705 - Method or system using biomarkers for the monitoring of a treatment: The present invention relates to biomarkers to monitor the activity of the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone or a pharmaceutically acceptable salt thereof, and especially its monoethanesulphonate salt form, when used alone or optionally in combination with further pharmaceutically active ingredients and/or further treatments, such as for example radiotherapy.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100233702 - Method to predict response to treatment for psychiatric illnesses: The disclosure provides methods and compositions useful for identifying a subject's predisposition to lithium treatment.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100233717 - Methods for detecting toxigenic microbes: The present invention provides methods and oligonucleotides for detecting toxigenic microbes, such as toxigenic Clostridium spp., in a sample.... Agent: 3m Innovative Properties Company

20100233722 - Methods for determining the biological effect and/or activity of r pharmaceutical compositions based on their effect on the methylation status of the dna: This invention is related to methods, systems and computer program products for determining the biological effect and/or activity of drugs, chemical substances and/or pharmaceutical compositions using their effect on DNA methylation as a marker for their biological effect(s). The invention is further related to the use of the inventive methods,... Agent: Epigenomics Ag

20100233693 - Methods for diagnosing, prognosing, or theranosing a condition using rare cells: The invention encompasses methods for diagnosing, theranosing, or prognosing a condition in a patient based on the results of one or more analysis methods. The methods can comprise enriching a sample obtained from the patient for one or more rare cells. The analysis methods can include performing enumeration of the... Agent: Wilson, Sonsini, Goodrich & Rosati

20100233704 - Methods of detecting lung cancer: Methods of lung cancer in a sample from a patient are provided. Methods of detecting changes in expression of one or more target RNAs associated with lung cancer are also provided. Compositions and kits are also provided.... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100233706 - Methods to fix and detect nucleic acids: In one aspect, the invention relates to a method for fixing a short nucleic acid in a biological sample. In another aspect, the invention relates to a method for detecting a target short nucleic acid in a biological sample. The method includes contacting the biological sample with an aldehyde-containing fixative,... Agent: Hoffmann & Baron, LLP

20100233696 - Methods, flow cells and systems for single cell analysis: A method, flow cell and/or device for increasing the recovery of a limiting analyte in a sample, e.g., for single molecule analysis is disclosed. Methods for preparing a nucleic acid sample from a single cell and capturing nucleic acids on a surface configured for use in or with single molecule... Agent: Lando & Anastasi, LLP

20100233695 - Molecular diagnosis and typing of lung cancer variants: Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. The expression of the gene or biomarker is indicative of the lung tumor subtype. The compositions include subsets of genes... Agent: Alston & Bird LLP

20100233686 - Multiplex quantitative nucleic acid amplification and melting assay: The invention is a single-tube multiplex assay, capable of simultaneously amplifying, detecting and quantifying multiple nucleic acid targets, using multiple hybridization probes, labeled with the same fluorescent reporter label, but each having a distinct melting temperature. The assay can be further multiplexed with the use of multiple sets of hybridization... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100233714 - Multistate affinity ligands for the separation and purification of antibodies, antibody fragments and conjugates of: Separation of antibodies, antibody fragments, and conjugates thereof using multistate affinity ligands rationally designed and selected to undergo analytically and functionally definable conformational transitions from a first affinity state under a first operator-defined environmental condition to a second affinity state under a second operator-defined environmental condition.... Agent: David M. Mcconoughey

20100233718 - Non-invasive technique for conducting skin inflammatory disease pharmaco-genomic studies and diagnoses thereof: Non-invasive techniques to conduct skin inflammatory disease pharmaco-genomic studies and diagnoses thereof feature discriminating biomarkers and genes and in vitro diagnostic methods employing such biomarkers.... Agent: Buchanan, Ingersoll & Rooney PC

20100233710 - Nucleic acid binding dyes and uses therefor: The invention provides novel compounds and compositions of Formulas I and II, as well as methods of using them. The compounds can be used, for example, to quantify an amount of double stranded DNA in a sample subjected to nucleic acid amplification, or for real time monitoring of a nucleic... Agent: Michael Best & Friedrich LLP

20100233699 - Primers and methods for the detection and discrimination of nucleic acids: The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR.... Agent: Life Technologies Corporation C/o Intellevate

20100233689 - Pyrazoloanthrone and derivatives thereof for the treatment of cancer expressing 'mullerian inhibiting substance' type ii receptor (misrii) and of excess androgen states: The present invention relates to pyrazoloanthrones or functional derivatives or functional analogues thereof to activate MIS receptor-mediated downstream effects in a cell. In particular, the present invention relates to method to prevent and treat cancer that expresses MIS receptor type II (MISRII) by administering to a subject at least one... Agent: David S. Resnick

20100233708 - Split flow device for analyses of specific-binding partners: The present invention provides an analyte detection system for detecting a target analyte in a sample. In particular, the invention provides a detection system capable of one-step amplification of the detection signal by incorporating a secondary flow path that can deliver reagents to a reaction zone. Methods of using the... Agent: Cooley LLP Attn: Patent Group

20100233716 - Transplant rejection markers: The invention relates to the analysis and identification of genes that are regulated simultaneously in chronic kidney transplant rejection. This simultaneous regulation of genes provides a molecular signature to accurately detect, and optionally classify, chronic kidney transplant rejection.... Agent: Novartis Corporate Intellectual Property

20100233685 - Two-color fluorescent reporter for alternative pre-mrna splicing: The present invention provides reporter constructs for in vivo or in vitro monitoring of alternative pre-mRNA splicing events. The reporter constructs described herein are also particularly useful for high-throughput screening of compounds that affect alternative pre-mRNA splicing. Kits comprising the reporter constructs of the present invention find utility in a... Agent: Townsend And Townsend And Crew, LLP

20100233700 - Ubiad1 gene and hyperlipidemia: The disclosure relates to genetic mutations in UBIAD1 gene that segregate with Schnyder's crystalline corneal dystrophy. The disclosure provides methods for detecting such mutations as a diagnostic for Schnyder's crystalline corneal dystrophy either before or after the onset of clinical symptoms. Also provided are screening methods for identifying medical conditions... Agent: C. Rachal Winger C/o Ocip Group

20100233690 - Use of genes identified to be involved in tumor development for the development of anti-cancer drugs and diagnosis of cancer: The invention relates to the use of inhibitors of the expressed proteins of the murine genes and/or their human homologues listed in Table 1 for the preparation of a therapeutical composition for the treatment of cancer, in particular for the treatment of solid tumors of lung, colon, breast, prostate, ovarian,... Agent: Barbara E. Johnson, Esq.

20100233701 - Use of non-clonal chromosomal aberrations for cancer research and clinical diagnosis: A diagnostic method of determining tumorigenicity of a tissue specimen includes the steps of determining the magnitude of genome diversity in the tissue specimen, and diagnosing a likelihood of cancer in response thereto. The magnitude of genome diversity includes the determination of karyotypic heterogeneity in tissue specimen, illustratively by detecting... Agent: Rohm & Monsanto, PLC

20100233723 - Dry stick device and method for determining an analyte in a sample: The present invention relates to a dry stick test device for the determination of an analyte in a sample by means of a chemical assay. The device comprises: (i) optionally a solid support, (ii) at least one reagent pad comprising a reagent capable of reacting with the analyte, a derivative... Agent: Foley And Lardner LLP Suite 500

20100233725 - Immunoassays employing non-particulate chemiluminescent reagent: Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and... Agent: Dade Behring Inc. Law And Patents

20100233727 - Marker for arrhythmia risk: The present invention relates to markers and methods for determining risk of ventricular arrhythmia in an African American or woman patient. By using the markers of the present invention, individual with high risk of ventricular arrhythmia can properly be detected and treated. The present inventors have discovered that, in African... Agent: Blank Rome LLP

20100233724 - Markers of non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash) and methods of use thereof: Novel methods for assessing the level of triglycerides in the liver of a subject are described, comprising determining the amount of a lipid metabolite in a sample from a body fluid of the subject. The methods may be used, for example, in diagnosing and monitoring liver disorders such as steatosis,... Agent: Marshall, Gerstein & Borun LLP (tethys)

20100233728 - Method and kit for detecting the early onset of renal tubular cell injury: A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury. NGAL protein expression is detected predominantly in... Agent: Hasse & Nesbitt LLC

20100233726 - Tandem fluorescent protein constructs: This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and acceptor moieties. The donor and acceptor moieties exhibit fluorescence resonance energy transfer which is eliminated upon cleavage. The constructs are useful in enzymatic... Agent: Townsend And Townsend And Crew, LLP

20100233730 - Therapeutic modulation of autophagy: Methods for screening for modulators of autophagy are disclosed. Methods for identifying genes whose expression inhibits autophagy, as well as genes whose expression promotes autophagy, are disclosed. Also disclosed are methods for identifying compounds that stimulate autophagy, as well as compounds that inhibit autophagy. Cell lines that may be used... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20100233731 - Detection and measurement of blood-feeding activity: This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the... Agent: Hodgson Russ LLP The Guaranty Building

20100233732 - Methods of determining patient response by measurement of her-2 expression: Methods are provided for determining or otherwise assessing the response of a patient to treatment, in particular, to cancer treatment. The methods include the analysis of samples for the presence or the absence of HER2 markers alone or in conjunction with other biomarkers, such as HER3 markers. In certain examples,... Agent: Kilpatrick Stockton LLP

20100233733 - Multiple mechanisms for modulation of the pi3 kinase pathway: An embodiment of the present invention is a method for measuring the post translational states and expression levels of proteins in the PI3K and/or mTor for use in diagnosis, prognosis and drug screening applications.... Agent: Wilson, Sonsini, Goodrich & Rosati / Nodality, Inc

20100233734 - Passivation of surfaces after ligand coupling: Passivated substrates are provided for use in assays, comprising at least one covalently bonded ligand having specific binding activity for a molecule, and at least one covalently bonded blocking agent, wherein said ligand is directly bonded to the substrate surface. In certain embodiments, the ligand and blocking agent are covalently... Agent: Varian Inc. Legal Department

20100233729 - Detecting interactions at biomimetic interfaces with liquid crystals: A method of forming a liquid crystal device, includes: contacting an aqueous solution comprising a surfactant and a receptor molecule with a top surface of a liquid crystal. The liquid crystal is in a holding compartment of a substrate, and the receptor molecule is adsorbed on the top surface of... Agent: Quarles & Brady LLP

20100233735 - Pharmaceuticals and methods for treating hypoxia and screening methods therefor: Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the... Agent: Fibrogen, Inc.

20100233736 - Detection method and kit: The present invention relates to a method of detection and/or quantification of an antigen linked to a metal salt. The antigen may be present within a mixture of different antigens, such as in a multivalent vaccine composition. The invention further provides a kit for use in the method of the... Agent: Glaxosmithkline Global Patents -us, Uw2220

20100233737 - Marker specific to an oxidative degradation of tissues containing type iii collagen, means and methods and kits for the diagnosis, monitoring or prognosis of pathologies targeted by this marker: Novel peptide marker, specific to the oxidative degradation of tissues containing type III collagen, preferably to nitrosylation of the type III collagen. This marker is defined of at least one peptide sequence of 5 to 25 amino acids (AAs) including a sub-sequence QYDSYD in which at least one of the... Agent: Pearne & Gordon LLP

20100233738 - Urine pretreatment agent for urinary protein quantitation, urine pretreatment method, and urinary protein quantitation method: The present invention is intended to develop a urine pretreatment agent, a urine pretreatment method, and a urinary protein quantitation method which reduce or cancel the influences of urine pH variations, cancel the influences of precipitates of urinary inorganic salts, and solubilize membrane proteins. The present invention provides: a urine... Agent: Akerman Senterfitt

20100233739 - Use of urinary ngal to diagnose unilateral and bilateral urinary obstruction: In one embodiment, the present invention is directed to methods for diagnosis of urinary tract obstruction (UTO), and to methods for distinguishing between unilateral and bilateral UTO. In some aspects, the diagnostic methods of the invention are based on determining whether a bodily fluid sample, such as a urine sample,... Agent: Wilmerhale/columbia University

20100233740 - Use of urinary ngal to distinguish kidney disease and predict mortality in subjects with cirrhosis: In one embodiment, the present invention is directed to methods for diagnosis of acute kidney injury (AKI) and hepatorenal syndrome (HRS) in cirrhosis patients, and to methods for distinguishing between AKI and/or HRS and/or other kidney diseases in cirrhosis subjects. In another embodiment, the present invention is directed to prognostic... Agent: Wilmerhale/columbia University

20100233741 - Immuno-based retargeted endopeptidase activity assays: The present specification discloses SNAP-25 immune response inducing compositions, methods of making α-SNAP-25 antibodies that selectively binds to an epitope comprising a SNAP-25 having a carboxyl-terminus at the P1 residue of the BoNT/A cleavage site scissile bond, α-SNAP-25 antibodies that selectively bind to an epitope comprising a SNAP-25 having a... Agent: Allergan, Inc.

20100233742 - Method of quantifying autoinducer-2: e

20100233743 - Bisubstrate fluorescent probe binding to protein kinases: This invention relates to fluorescent probes for identification of compounds binding to protein kinases, for measurement of the affinity of inhibitors of protein kinases, and determination of the active concentration of protein kinases binding to the probe. Bisubstrate-analog character of the probe enables the simultaneous evaluation of inhibitors targeted to... Agent: Birch Stewart Kolasch & Birch

20100233744 - Enzyme substrates for visualizing acidic organelles: The present invention relates to the visualization of acidic organelles based upon organelle enzyme activity. The organelle substrates of the invention are specific for enzyme activity of the organelle and label these organelles, such as lysosomes, rendering them visible and easily observed. Substrates of the present invention include substrates that... Agent: Dr. John Naleway Marker Gene Technologies

20100233745 - Detecting a microorganism strain in a liquid sample: The invention concerns a medium for detecting, identifying and differentiating a microorganism strain in a liquid medium by contacting said liquid sample with a combination of chromogens substrates of enzymes expressed or not by the strain to be detected, the final coloration of the mixture being detectable in the wavelengths... Agent: Alston & Bird LLP

20100233746 - Inflammation and oxidative stress level assay: The present invention relates to a method for determining the systemic metabolic status of an organism in relation to inflammation and oxidative stress using a biological sample (Inflammation and Oxidative Stress Level Assay). This comprises detection and quantification of one or more derivatives of arachidonic acid (eicosanoids), linoleic acid and/or... Agent: Thorpe North & Western, LLP.

20100233747 - Method and means for the enzymatic determination of ethanol: The invention relates to a method and means for the enzymatic determination of ethanol. The method according to the invention prevents ethanol vapours in the ambient air from interfering with the determination.... Agent: Millen, White, Zelano & Branigan, P.C.

20100233751 - Apparatus and method for monitoring cultures: Disclosed is a bubble excluder device (2) adapted for use with, and attachment to, a probe (6) for continuous measurement of the cell density of a culture in a liquid medium; the bubble excluder device comprising an inlet and an outlet to allow flow of liquid through the device and... Agent: Barnes & Thornburg LLP

20100233749 - Device with biological component and method of making to achieve a desired figure of merit: An improved method for the design and development of high performance hybrid devices having biologically-derived and nonbiological components and the hybrid devices so-designed and developed. A desired figure of merit is determined for the biologically-derived component or components. The organism from which the biologically-derived component is derived is subjected to... Agent: Gallagher & Kennedy, P. A.

20100233748 - Device with biological component and method of making to achieve a desired transfer function: An improved method for the design and development of high performance hybrid devices having biologically-derived and nonbiological components and the hybrid devices so-designed and developed. A desired transfer function is determined for the biologically-derived component or components. The organism from which the biologically-derived component is derived is subjected to various... Agent: Gallagher & Kennedy, P. A.

20100233750 - Human blood brain barrier model: The present invention relates to an immortalized human brain endothelial cell line that is useful as an in vitro model of the blood brain barrier.... Agent: Stites & Harbison PLLC

20100233752 - Method for diagnosis and monitoring of disease activity and response to treatment in systemic lupus erythematosus (sle) and other autoimmune diseases: The present invention provides methods of diagnosing and monitoring systemic lupus erythematosus and drug-induced lupus erythematosus by measuring cell-based complement activation products in a subject's blood. In particular, the invention describes a diagnostic method employing the measurement of multiple complement activation products, such as C3d and C4d, on the surfaces... Agent: Cooley LLP Attn: Patent Group

20100233753 - Optical measuring device and method therefor: The light measurement apparatus of the invention, in which the light is irradiated to the sample dispersed in the liquid flowing through the flow passage, is used for measuring optical information of the sample. The apparatus includes a light source portion 20 for irradiating the irradiating light L to the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100233755 - Pdx1-expressing dorsal and ventral foregut endoderm: Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm... Agent: Knobbe Martens Olson & Bear LLP

20100233754 - Vessel transporting apparatus and method: This disclosure relates to an apparatus for transporting a vessel and to a sorting apparatus. The apparatus has at least one support device adapted to support the vessel in a reclined orientation, and a pushing mechanism adapted to transport the vessel along the support device. Advantageously, the apparatus is relatively... Agent: Mayback & Hoffman, P.A.

20100233756 - Animal feed kibble with protein-based core and related methods: Kibble-type animal feeds and pet foods including a vegetable protein-based core matrix and a coating of a fat and at least one additive are described. The coating may include a probiotic enriched coating. Methods of forming the kibble-type animal feeds and pet foods are also described. Probiotic coating for a... Agent: The Procter & Gamble Company Global Legal Department - Ip

20100233757 - Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap: New RNA cap analogs are disclosed containing one or more phosphorothioates groups. The analogs also contain modifications at the 2′-O position of 7-methylguanosine that prevent them from being incorporated in the reverse orientation during in vitro synthesis of mRNA and that hence are “anti-reverse cap analogs” (ARCAs). The ARCA modification... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20100233759 - Method for production of polypeptide: The present invention relates to a method of producing a polypeptide, comprising culturing a cell which strongly expresses cysteine sulfinic acid decarboxylase and has a transferred DNA encoding a desired polypeptide and thereby allowing the cell to produce the polypeptide. Hamster cysteine sulfinic acid decarboxylase, a DNA encoding the same,... Agent: Foley And Lardner LLP Suite 500

20100233758 - Protein increasing cell infectivity of herpes simplex virus and use thereof: Provided are an isolated protein derived from an N-terminal of HveA/HVEM and having activity of increasing the cell infectivity of herpes simplex virus (HSV) and use thereof.... Agent: Cantor Colburn, LLP

20100233760 - Protein production in microorganisms of the phylum labyrinthulomycota: The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.... Agent: Sterne, Kessler, Goldsein & Fox P.l.l.c

20100233761 - Algae biomass fractionation: A method of fractionating biomass, by permeability conditioning biomass suspended in a pH adjusted solution of at least one water-based polar solvent to form a conditioned biomass, intimately contacting the pH adjusted solution with at least one non-polar solvent, partitioning to obtain an non-polar solvent solution and a polar biomass... Agent: Kohn & Associates, PLLC

20100233763 - Dual-sided thermal cycler: A device, system, and method are provided for thermally treating a fluid processing device. According to various embodiments, a system is provided that can include a thermal device and a fluid processing device holder. The thermal device can include a first block having a thermal conductivity greater than 0.5 Watt... Agent: Kilyk & Bowersox, P.l.l.c.

20100233762 - Thermostable y-family polymerases and chimeras: The present disclosure is related to thermostable Y-family polymerases, in particular several novel Y-family polymerases and chimeras made therefrom, as well as methods of identifying other Y-family polymerases, methods of generating other chimeric Y-family polymerases, methods of amplifying ancient or damaged DNA, and methods of incorporating fluorescent or modified nucleotides... Agent: Klarquist Sparkman, LLP (ott-nih)

20100233764 - Process for producing poly-y-glutamic acid having high optical purity: It is an objective of the present invention to provide a process for efficiently producing poly-γ-glutamic acid having a high L-glutamic acid content and excellent quality. The process for producing poly-γ-glutamic acid according to the present invention is characterized in using a bacterium belonging to species Bacillus megaterium.... Agent: Bacon & Thomas, PLLC

20100233765 - L-cysteine-producing bacterium and a method for producing l-cysteine: The present invention provides a bacterium belonging to the family Enterobacteriaceae, which is able to produce L-cysteine, and has been modified to decrease activity of the YdjN protein, or the activities of the YdjN and the FliY protein. This bacterium is cultured in a medium, and L-cysteine, L-cystine, a derivative... Agent: Cermak Nakajima LLP Acs LLC

20100233766 - Novel microorganism and method for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using the novel microorganism: This invention relates to a novel microorganism that efficiently produces a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. As a result of concentrated studies, a plurality of novel microorganisms having properties of interest that are not classified as conventional microorganisms were isolated and identified. The novel microorganism of the present... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100233767 - Process for the recovery of magnesium from a solution and pretreatment: A process for the recovery of magnesium from a solution containing soluble magnesium, the process comprising, precipitating magnesium hydroxide from the solution, forming an oxide blend including magnesium oxide derived from the precipitated magnesium hydroxide together with calcium oxide, reducing the oxide blend to form a magnesium metal vapour and... Agent: Berliner & Associates

20100233768 - Method for isolating polyhyroxyalkanoates: p

20100233769 - Biomass treatment process: A process for the treatment of biomass is provided. The process comprises forming a biomass slurry by mixing biomass with a working fluid, and inducing the biomass slurry to flow through an inlet into a passage. A high velocity transport fluid is injected into the slurry through a nozzle communicating... Agent: Kevin C.hooper, Esq. Bryan Cave LLP

20100233770 - Method of continuously producing ethanol and electricity from a sustainable renewable biomass feedstock: Disclosed is a method of continuously producing ethanol and electricity from a sustainable renewable biomass feedstock in a processing plant contiguous to the acreage providing the biomass. The process is a closed loop operation having a dedicated crop grown year round producing multiple crops per acre. The renewable biomass feedstock... Agent: Steven L. Schmid

20100233771 - System for pre-treatment of biomass for the production of ethanol: A system for the pre-treatment of biomass for use in a biorefinery to produce ethanol and other bioproducts is disclosed. The system comprises a method comprising the steps of preparing the biomass into prepared biomass; pre-treating the prepared biomass into pre-treated biomass by application of a dilute acid having a... Agent: Womble Carlyle Sandridge & Rice, PLLC

20100233772 - Modular system for introducing a stream of processed grain into an ethanol production facility, and associated methods: A modular system is provided to introduce a grain containing a commercial enzyme into an ethanol production facility. The modular system comprises a plurality of portable storage units configured to receive a raw grain material. Each storage unit is adapted for transportation between ethanol production facilities. A portable processing unit... Agent: Syngenta Biotechnology, Inc. Patent Department

20100233773 - Saccharifying cellulose: Dissolution, partial dissolution or softening of cellulose in an ionic liquid (IL) and its subsequent contact with anti-solvent produces regenerated cellulose more amorphous in structure than native cellulose, which can be separated from the IL/anti-solvent mixture by mechanical means such as simple filtration or centrifugation. This altered morphology of IL-treated... Agent: Hunton & Williams LLP Intellectual Property Department

20100233774 - Circulatory biomass energy recovery system and method: A circulatory biomass energy recovery system and method raising an energy recovery efficiency are provided. The circulatory biomass energy recovery system has a culture unit 10 filled with a culture solution culturing phytoplankton as a biomass material, a biomass material recovery unit 11 recovering the biomass material from the culture... Agent: Birch Stewart Kolasch & Birch

20100233775 - System for the production of methane and other useful products and method of use: A system for the production of methane and other useful products and method of use for generating green natural gas as a fuel or component for use in the manufacturing of specialty chemicals. The system for the production of methane and other useful products and method of use includes a... Agent: Ekse Law Firm, PC

20100233776 - Novel hydrogen-producing bacterium: The present invention aims to provide a hydrogen-producing bacterium, which excels in hydrogen yield and hydrogen production rate, and is usable for industrial hydrogen production from biomass as a production source. That is, it is intended to provide a bacterium belonging to the genus Clostridium which has a property of... Agent: Wood, Herron & Evans, LLP

20100233777 - Systems and methods for achieving partial nitrification in a biological nitrogen removal reactor: Methods of controlling a nitrification reaction in a biological nitrogen removal reactor to favor partial nitrification of ammonia to nitrite instead of complete oxidation of ammonia to nitrate are disclosed. In some embodiments, the methods include the following: maintaining a pH in the reactor within a range that promotes growth... Agent: Wiggin And Dana LLP Attention: Patent Docketing

20100233778 - Device and process for generating biogas from organic materials: The invention relates to a device for generating biogas from organic materials having a biogas reactor which has a charging chamber for being charged with the organic materials and a backflow channel for an at least partial discharge of the organic materials from the biogas reactor. According to the invention... Agent: Dobrusin & Thennisch PC

20100233779 - Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites: The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may... Agent: Immunomedics, Inc.

20100233780 - Methods for improving protein properties: The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes... Agent: Danisco US Inc. Attention: Legal Department

20100233782 - Isolated phospholipid-protein particles: Systems and methods are provided for producing a protein of interest that is typically not amenable to expression in soluble form in in vitro expression systems. In some aspects, the invention provides methods of synthesizing proteins using in vitro protein synthesis systems that include a scaffold protein such as apolipoprotein... Agent: Life Technologies Corporation C/o Intellevate

20100233781 - Tubular nanostructure targeted to cell membrane: Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form... Agent: The Invention Science Fund Clarence T. Tegreene

20100233783 - Novel method for protein purification: Process for purifying a recombinant protein including one or a few procedural steps only. The process combines the step of lysis of the host cell, with the purification of the protein of interest, allowing for a rapid and much more efficient process of purification. The conditions used during the purification... Agent: Rissman Hendricks & Oliverio, LLP

20100233784 - Method and kit for isolating and fractioning phosphoproteins: Disclosed herein a method and a kit for fractioning/isolating phosphoproteins. Calcium ions, barium ions, cobalt ions and molybdenum ions are bound specifically to phosphoproteins to form metal-phosphoprotein complexes. They can be easily precipitated with precipitants including sulfates, citrates, bicarbonates and carbonates.... Agent: Intellectual Property Law Group LLP

20100233785 - Novel methods and interferon deficient substrates for the propagation of viruses: The present invention relates, to novel methods and substrates for the propagation of viruses. The invention relates to IFN-deficient substrates and methods for propagating viruses in these unconventional substrates. In particular, the invention relates to methods of propagating viruses in immature embryonated eggs, preferably six- to nine-day-old chicken eggs. The... Agent: Michael Fedrick

20100233787 - Energy production from algae in photo bioreactors enriched with carbon dioxide: A cyclic system composed of several integrated cyclic processes and a method for production of cement and or quicklime, ammonia, desalinated water and an excess of algae cells. The system comprises of: at least cement/quicklime production plant, at least ammonia production plant, at least one water desalination unit, at least... Agent: The Law Office Of Michael E. Kondoudis

20100233786 - Liquid fuel from aquatic biomass: Disclosed is a plant for producing aquatic biomass. The plant comprises a pond adapted for growing aquatic biomass, a system for providing CO2 to said pond, and a CO2 capturing material capable of reversibly capturing CO2. The CO2 capturing makes it possible to uncouple the production of the aquatic biomass... Agent: Howrey LLP-eu

20100233788 - Apparatus and method for catalytic treatment of a media: s

20100233789 - Method and system for removing co2 from the atmosphere: A system for removing gaseous pollutants from air enriched with the pollutants includes a cultivation environment configured to cultivate vegetation under exposure to pollutant enriched air, and a transformation unit configured to transform an encapsulation material to a transitory viscous or liquid state. Further, the system includes a mixing unit... Agent: Dickinson Wright PLLC

20100233790 - Method for biological treatment of an air stream containing vocs: A method of operating a facility that produces an emission air stream containing gas phase organic compounds includes providing a bio-oxidation system including a solid, biologically active filter material containing a population of thermophilic microbes. The emission air stream is supplied to the bio-oxidation system at a temperature of at... Agent: Chernoff, Vilhauer, Mcclung & Stenzel, LLP

20100233791 - Cell-chip and automatic controlled system capable of detecting conditions for optimizing differentiation of stem cell using mechanical stimulus: Provided are a cell chip and a system thereof that are capable of detecting optimal conditions for stem cell differentiation by mechanical stimuli. The cell chip for cell differentiation experimentation includes a plurality of cell chambers for storing cells and culture media, cell and culture medium injection ports for transferring... Agent: Rabin & Berdo, PC

20100233793 - Healthcare management apparatus, healthcare management method, and display method of determination results: Preferably, the acquiring means further comprise health assessment formula and health condition determination criteria. The processing means calculates a health condition determination relative values by combining two or more of the relative values and/or the health condition determination relative values and using total health assessment formula and determines a total... Agent: Birch Stewart Kolasch & Birch

20100233792 - Microdevices for chemical sensing and chemical actuation: The invention relates to sensors for detecting chemical and biological material and for chemical actuation. In particular, the sensors of the present invention incorporates membranes or beams that are deformable in the presence of chemical adsorption on its surface. The sensor of the present invention contains a polymeric membrane or... Agent: Blank Rome LLP

20100233794 - Suction device and analysis device: Each of nozzles includes a micropore which is used as a channel, and the channel is exposed to the outside in the vicinity of a front end of the nozzle. An arm supports the nozzles so that the front ends of the nozzles are movable in an insertion/extraction direction, in... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100233795 - Fermentation vessels: A fermentation apparatus (10) with a fermentation vessel (12) having a low speed stirrer comprising a shaft (14) with at least one stirring element (18) mounted thereon. First and second seal assemblies (30, 50), spaced axially from one another to define a chamber (64) therebetween, are provided to seal a... Agent: Davis & Bujold, P.l.l.c.

20100233796 - Fuel cell system and method of controlling same: A fuel cell system includes a fuel cell configured to generate electric power with a fuel gas and an oxygen gas fed to the fuel cell and to discharge exhaust gas including CO2 as a result of generating the electric power; a CO extraction part configured to reduce the CO2... Agent: Kratz, Quintos & Hanson, LLP

20100233797 - Bio-wall: A bioremediation device in the form of a cylindrical cartridge having an open mesh side wall and end-caps forming an enclosed volume and which contains a suitable media. The cartridge is removeably mounted in and supported on opposite sides by wall halves in the form of near semi-circular housing halves.... Agent: Marjama Muldoon Blasiak & Sullivan LLP

20100233798 - Centrifugal force-based microfluidic device and method of fabricating the same: Provided are a centrifugal force-based microfluidic device, in which biochemical treatments of samples are executed, and a method of fabricating the centrifugal force-based microfluidic device. The centrifugal force-based microfluidic device is mountable on a rotatable device and includes: a disk-shaped portion; and an inlet hole defined within, configured to receive... Agent: Staas & Halsey LLP

20100233799 - Integrated microfluidic control employing programmable tactile actuators: Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled,... Agent: Casimir Jones, S.c.

20100233800 - Filtered petri dish: A petri dish includes a cover and base, the cover having at least one circular opening in the top of the cover. A number of securing members are connected to the underside of the cover around the opening to secure at least one filter under the opening, the filter(s) being... Agent: Jones Day

20100233801 - Centrifugal force based microfluidic device, biochemical treatment system having the same, and method of fabricating the microfluidic device: Provided are a centrifugal force-based microfluidic device in which biochemical treatments of samples are executed, a biochemical treatment system including the centrifugal force-based microfluidic device, and a method of fabricating the centrifugal force-based microfluidic device. The centrifugal force-based microfluidic device includes a rotational platform including a unit to perform biochemical... Agent: Staas & Halsey LLP

20100233802 - Cells useful for immuno-based botulinum toxin serotype a activity assays: The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines.... Agent: Allergan, Inc.

20100233803 - Fusion polypeptides capable of activating receptors: A fusion polypeptide comprising (A)x-M-(A′)y, wherein A and A′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A′ may be each be an antibody or fragment derived from an antibody specific for a... Agent: Regeneron Pharmaceuticals, Inc

20100233804 - Generation of pluripotent stem cells using recombinant proteins: The present invention provides for methods, compositions, and kits of producing an induced pluripotent stem cell from a mammalian non-pluripotent cell using exogenous transcription factors.... Agent: Townsend And Townsend And Crew, LLP

20100233805 - Method of enhancing cell growth using alkyl-amine-n-oxide (aanox): The present invention relates to a method to enhance cell growth in culture comprising adding an alkyl-amine-n-oxide (AANOx), such as dodecyldimethylamine oxide (DDAO), into the culture medium in an amount sufficient to improve cell growth.... Agent: Marshall, Gerstein & Borun (baxter)

20100233806 - Carbocyclic bicyclic nucleic acid analogs: Provided herein are saturated and unsaturated carbocyclic bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using these oligomeric compounds. The saturated and unsaturated carbocyclic bicyclic nucleosides are useful for enhancing properties of oligomeric compounds including nuclease resistance.... Agent: Jones Day For Isis Pharmaceuticals, Inc.

20100233807 - Substrate recognition by differentiable human mesenchymal stem cells: The invention described herein provides a structure for growing isolated differentiable human mesenchymal cells, which includes a three-dimensional matrix of fibers. The matrix serves as an implantable scaffolding for delivery of differentiable human mesenchymal cells in tissue engineering. The invention further provides compositions that contain the three-dimensional matrix of fibers... Agent: Mccarter & English, LLP Stamford

20100233808 - Liver tissue source: The instant invention provides, for the first time, the use of cadaveric organs from donors with non-beating hearts as a source of functional cells such as progenitor or stem cells for various medical purposes. More specifically, a method is disclosed whereby a tissue source of progenitor cells is obtained comprising... Agent: Foley And Lardner LLP Suite 500

20100233809 - Cytotoxic ribonuclease variants: This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the ribonuclease inhibitor while still retaining catalytic properties. While earlier work had identified some... Agent: Quarles & Brady LLP

20100233810 - In vivo production of small interfering rnas that mediate gene silencing: The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100233811 - Cell seeding module: An apparatus and method is described for seeding cells on a sample or specimen. The cells may be selectively and locally seeded on an upper and lower surface of a planar sample or specimen or on either or both of an interior luminal surface and exterior surface of a hollow... Agent: Paul T Dietz Dietz Law Office LLC

20100233812 - Membrane made of a nanostructured material: The present invention refers to a method of fabricating a membrane made of a nanostructured material and its use.... Agent: Seed Intellectual Property Law Group PLLC

20100233813 - Plant stem cell line derived from cambium of herbaceious plant with storage root and method for isolating the same: The present invention relates to a cell line derived from the cambium of an herbaceous plant having a storage root and a method for isolating the same. More specifically, relates to a cambium-derived homogeneous cell line having the ability to divide, which is obtained from the cambium-containing storage tissue of... Agent: Edwards Angell Palmer & Dodge LLP

20100233814 - Bacterial strains with improved plasmid stability: The present invention relates to the propagation of covalently closed circular recombinant DNA molecules such as plasmids, cosmids, bacterial artificial chromosomes (BACs), bacteriophages, viral vectors and hybrids thereof, and more particularly is strain modifications that improve strain viability, plasmid stability, plasmid production yield, and plasmid-directed protein production yield, using said... Agent: J.k. Weatherspoon & Associates, LLC

  
09/09/2010 > patent applications in patent subcategories. class, title,number

20100227307 - Ergothioneine and/or its derivatives as a cell preservative: The present invention relates to cell, tissue or derivatives thereof, preserving compositions for cells in culture, storage, or lyophilization. According to the invention ergothioneine is added as a supplement to such extender or preservative compositions. Sperm cells so treated showed increased motility when thawed compared to cells that were not... Agent: Klauber & Jackson

20100227308 - Information acquisition method, information acquisition apparatus and disease diagnosis method: An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the... Agent: Fitzpatrick Cella Harper & Scinto

20100227309 - Method for quantitatively determining ldl cholesterols: A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholestrols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100227310 - Flow cytometry methods and immunodiagnostics with mass sensitive readout: Mass cytometry method. In one aspect, the method includes providing a sample having at least one cell type and mixing the sample with material such as nanoparticles functionalized with affinity molecules for the at least one cell type. The sample is transported through a suspended microchannel resonator to record a... Agent: Choate, Hall & Stewart LLP

20100227314 - Method of identification of genotype and subtype of hepatitis c virus on a biological microchip: The invention relates to molecular biology, virology and medicine and provides a method for identifying a genotype and a subtype of Hepatitis C virus (HCV) on the basis of the analysis of an HCV genome NS5B region using a differentiating biochip. The method of the present invention is based on... Agent: Oliff & Berridge, PLC

20100227313 - Methods and compositions for determining altered susceptibility of hiv-1 to protease inhibitor treatment: This invention relates to methods for determining altered susceptibility of HIV-I viruses to protease inhibitors (PIs) based on the viral genotypes. The methods generally comprise detecting, in a gene encoding protease and/or gag of the HIV-I, the presence of mutations correlated with altered susceptibility to amprenavir and/or darunavir.... Agent: Kilpatrick Stockton LLP

20100227312 - Particle adhesion assay for microfluidic bifurcations: A method for characterizing particle adhesion in microfluidic bifurcations and junctions comprises at least one idealized bifurcation or junction. Multiple bifurcations and/or junctions can be combined on a single microfluidic chip to create microfluidic networks configured for assays specifically to characterize particle interactions at junctions or to screen particles for... Agent: Tomas Friend, LLC

20100227311 - Tissue culture system for production of hepatitis c virus: A tissue culture system for production of infectious hepatitis C virus is described. In particular, the invention provides recombinant monocistronic and bicistronic genomic constructs for production of virus, including constructs for production of wild-type HCV type 2a strain JFH1 and constructs for production of chimeric viruses comprising HCV proteins from... Agent: Novartis Vaccines And Diagnostics Inc.

20100227315 - Biosensor using whispering gallery modes in microspheres: A biosensor for detecting the presence of a target analyte is disclosed. The biosensor is formed from microspheroidal particles which have had a binding partner for the target analyte immobilized on their surfaces. The binding partners may be nucleotides; peptides, proteins, enzymes, antibodies and so on. When the analyte binds... Agent: Knobbe Martens Olson & Bear LLP

20100227322 - Detection of bordetella: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further... Agent: Fish & Richardson P.C.

20100227331 - Detection of immobilized nucleic acid: The present invention provides methods for determining the presence of immobilized nucleic acid employing unsymmetrical cyanine dyes that are derivatives of thiazole orange, a staining solution and select fluorogenic compounds that are characterized as being essentially non-genotoxic. The methods comprise immobilizing nucleic acid, single or double stranded DNA, RNA or... Agent: Life Technologies Corporation C/o Intellevate

20100227326 - Detection system: A method for detecting the presence of a target nucleic acid sequence in a sample, said method comprising: performing nucleic acid amplification on the sample in the presence of (a) a DNA duplex binding agent, (b) a nucleic acid polymerase and (c) a reagent comprising an amplification primer which can... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20100227328 - Dnazymes and sensors incorporating the same: An arsenic ion active DNAzyme includes a nucleotide sequence, which has a base sequence selected from ATCTCCTCCTGTTC (SEQ ID NO: 62), ATCTGCTCCTGTTC (SEQ ID NO: 63), ATCTCCTCATGTTC (SEQ ID NO: 64), ATCTCCTCTTGTTC (SEQ ID NO: 65), ATCTCCAACCTGTTC (SEQ ID NO: 66), and CCGTAGCGCAAAT (SEQ ID NO: 67). A mercury ion... Agent: Julia Church Dierker Dierker & Associates, P.C.

20100227316 - Luminescense measuring apparatus and luminescense measuring method: There is provided a novel luminescence measuring apparatus that enables measuring a luminescence amount or a luminescence intensity from plural living biological samples, such as tissues, cells, and biological individuals, into which a gene expressing a luminescent protein has been introduced, individually for the respective biological samples. The inventive luminescence... Agent: Scully Scott Murphy & Presser, PC

20100227324 - Measurement of arylesterase enzymatic activity and assessment of genetic polymorphisms located in the pon1 gene as a diagnostic tool in autism-spectrum disorders: The present invention concerns a method for detecting the presence of or predisposition to autism, an autism spectrum disorder, or an autism-associated disorder in a subject, the method comprising measuring an arylesterase enzymatic activity in a sample from the subject, optionally combined with the determination of alleles of PON1 polymorphisms.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100227318 - Method for controlling the amount of gene product, and agent for controlling the amount of gene product: The invention relates to a method of intracellularly controlling amounts of gene products, which can increase an amount of gene product intracellularly, comprising a step of introducing into the cell a substance having a sequence complementary to the base sequence of mRNA corresponding to the gene product, its precursor or... Agent: Sughrue Mion, PLLC

20100227332 - Method for selecting antimicrobial agent and utilization thereof: The present invention provides for a method for selecting an antimicrobial agent, which comprises a microbe analyzing step in which microbes in the microbial biota of a sample are analyzed based on base sequence of DNA and an antimicrobial agent selecting step comprising performing search in a data base storing... Agent: Flynn Thiel Boutell & Tanis, P.C.

20100227317 - Method for the molecular diagnosis of prostate cancer and kit for implementing same: The invention relates to a method for the molecular diagnosis of prostate cancer, comprising the in vitro analysis of the overexpression or underexpression of combinations of genes that can distinguish, with high statistical significance, tumorous prostate samples from non-tumorous prostate samples. The invention also relates to a kit for the... Agent: Traskbritt, P.C.

20100227327 - Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides: Disclosed herein are methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides.... Agent: Clark & Elbing LLP

20100227321 - Methods and devices for nucleic acid sequence determination: Methods of the invention comprise methods and devices for nucleic acid sequence determination. Generally, the invention relates to preparing a substrate for sequencing a target nucleic acid... Agent: Brown Rudnick LLP

20100227330 - Methods for diagnosing episodic movement disorders and related conditions: The present invention provides compositions and methods for research, diagnostic, drug screening, and therapeutic applications related to paroxysmal dystonic choreoathetosis and related conditions. In particular, the present invention provides mutations in the myofibrillogenesis regulator 1 (MR-1) gene associated with such conditions.... Agent: Casimir Jones, S.c.

20100227325 - Methods of detecting sepsis: Methods of sepsis in a sample from a patient are provided. Methods of detecting changes in expression of one or more microRNAs associated with sepsis are also provided. Compositions and kits are also provided.... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100227323 - Microchannel detection device and use thereof: The present invention relates to a device and methods for detecting or quantifying an analyte in a test sample. The device includes a substrate defining one or more microchannels and having a reaction region in a first portion of the one or more microchannels, wherein the reaction region contains a... Agent: Nixon Peabody LLP - Patent Group

20100227320 - Nucleic acid detection: This invention provides methods and kits for enriching and/or detecting a nucleic acid with at least one variant nucleotide from a nucleic acid population in a sample. Methods employ the use of enriching primers and bridge-probes for enriching and detecting target nucleic acids. Extension of the enriching primer permits amplification... Agent: Michael Best & Friedrich LLP

20100227329 - Tools and methods for genetic tests using next generation sequencing: The present invention provides tools and methods for use in genetic tests involving high performant sequencing techniques. More particularly, the invention provides a robust multiplex PCR method wherein the respective primers for amplifying the different amplicons are physically isolated from one another. The invention further provides quality control methods allowing... Agent: Clark & Elbing LLP

20100227319 - Use of runx3 and mir-532-5p as cancer markers and therapeutic targets: The invention relates to methods for cancer diagnosis, prognosis, and treatment based on the expression or activity levels of RUNX3 and miR-532-5p. Also disclosed is a method of reducing the inhibition of RUNX3 by miR-532-5p with an agent that interferes with the interaction between RUNX3 and miR-532-5p transcripts.... Agent: Perkins Coie LLP

20100227333 - Method of detecting infection with urogenital mycoplasmas in humans and a kit for diagnosing same: A method and a kit are provided for detecting an infection by mycoplasma, particularly an urogenital infection in humans. The presence of specific anti-mycoplasma antibodies in a biological sample of a diagnosed subject is detected by reaction with an immobilized mixture of various antigenic determinants associated with a variety of... Agent: Hunton & Williams LLP Intellectual Property Department

20100227334 - Reaction sensing in living cells: Chemical reactions occurring within a living cell are measured in a manner that does not affect the viability of the cell or the reaction under study. In one embodiment, one or more sensors are introduced into the cell and/or covalently associated with the exterior cell membrane. The sensor(s) emit an... Agent: Goodwin Procter LLP Patent Administrator

20100227337 - Method for evaluating risk in multiple sclerosis: The invention relates to methods and reagents for diagnosing and assessing the prognosis of multiple sclerosis.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100227338 - Method and apparatus for rapid detection and identification of live microorganisms immobilized on permeable membrane by antibodies: An apparatus and method is provided for the rapid detection, identification and/or enumeration of one or more live target microorganisms growing on solid nutrient media or filtration membrane. Microcolonies or colonies attach to a porous transfer permeable membrane loaded with immobilized antibodies specific for target microorganisms. Non-specific cells are washed... Agent: Thompson Hine L.L.P. Intellectual Property Group

20100227335 - Matrix metalloproteinase-7 (mmp-7) monoclonal antibodies and methods for their use in the detection of ovarian cancer: Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MMP-7. Monoclonal antibodies having the binding characteristics of an MMP-7 antibody... Agent: Alston & Bird LLP

20100227336 - Method for the measure of molecular interactions by measurement of the light reflected by planar surfaces: Procedure for the quantitative determination of interactions of ligands with receptors adsorbed or immobilized on the surface of a solid material which can be functionalized, transparent and with low refractive index, by direct measure of the reflection of light.... Agent: Young & Thompson

20100227341 - Diagnosing pneumococcal pneumonia: Compositions and methods for eliciting an immune response against Streptococcus pneumoniae are described. More particularly, the present disclosure relates to immunogenic PcpA polypeptides, including fragments of PcpA and variants thereof, and nucleic acids that encode the polypeptides. The present disclosure further relates to methods of making and using the immunogenic... Agent: Fish & Richardson P.C.

20100227342 - Diagnosis of preeclampsia: The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained from pregnant women and the effects of such levels on the risk of developing complications of pregnancy, including hypertensive disorders such as... Agent: Wolf Greenfield & Sacks, P.C.

20100227339 - Differential immunoassay for prrs vaccine antibody: The present invention relates to immunoassays for serologically differentiating animals naturally infected with PRRS virus from animals vaccinated against PRRS. The immunoassays provide detection of at least a portion of the N terminal region of the 2b portion of PRRSV. The immunoassay is preferably an enzyme-linked immunosorbent assay (ELISA).... Agent: Mckee, Voorhees & Sease, P.L.C

20100227340 - Method of analysis, detection and correction of food intolerance in humans: A method of detection and correction of latent food intolerance (LFI) in humans is described. The method allows, through utilizing a dynamic analysis of a specific test for LFI, assessing the degree of food intolerance and devising an individualized diet that excludes food items which cause latent food intolerance, as... Agent: Rankin, Hill & Clark LLP

20100227343 - Glycodelin monoclonal antibodies and methods for their use in the detection of ovarian cancer: Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody... Agent: Alston & Bird LLP

20100227344 - Methods for measuring adp: This invention relates to assays for detecting and measuring ADP. In particular, this invention provides homogeneous luminescent assays that detect ADP generation and measures ADP accumulation based on enzymatic coupling reactions. The assays of the present invention can be applied to all types of kinases and other ADP-generating enzymes, are... Agent: Scully Scott Murphy & Presser, PC

20100227345 - Enzyme containing liquid and delivery system for detection of analytes on surfaces: An aqueous enzyme based sensor comprising one or more enzymes and at least one indicator compound capable of indicating a reaction of at least one of the enzymes with at least one target analyte, wherein the enzyme and the indicator are capable of being delivered, preferably by being sprayed, to... Agent: Buchanan Ingersoll & Rooney PC

20100227346 - Activation mixture: The present invention relates to an activation mixture comprising factor-deficient substrate plasma, an activator, and a phospholipid. The present invention also relates to a method for preparing, and the use of, an activation mixture. The present invention further relates to an assay method for determining the amount of blood coagulation... Agent: Frommer Lawrence & Haug

20100227347 - Diagnostic test calibration adjustment method: A method is provided for adjusting either the signal measured or activity calculated by an instrument or a predefined calibration curve for a medical diagnostic test, performed on an instrument with pre-calibrated reagents. A calibration adjuster for a blood clotting diagnostic test is further provided.... Agent: Young & Thompson

20100227348 - Method and device for determining the concentration of an analyte using fluorescence measurement: A method is presented for determining the concentration of an analyte in a liquid sample using a reagent system. The reaction of the sample with the reagent system results in a change of the quantity of a fluorophore, the quantity of the fluorophore correlating with the concentration of the analyte,... Agent: Roche Diagnostics Operations Inc.

20100227351 - method of detecting and separating serum gamma-glutamyl transferase (ggt) isoforms in a sample of biological fluid and the enzyme isoforms thereby obtained: A method is described for detecting the gamma-glutamyl transferase enzyme isoforms (GGT, EC 2.3.2.2) in a sample of biological fluid, such as for example plasma or serum. The method comprises an HPLC separation step of the sample proteins based on the molecular size and a second step for detecting the... Agent: Dennison, Schultz & Macdonald

20100227350 - Method of screening substance useful in treating disease with the use of gpr40 and phospholipase: The present invention relates to a screening method for determining whether a substance of interest is a substance which alters GPR40-mediated cell stimulating activities, comprising using a substance of interest, a biomembrane containing GPR40, or cells containing said biomembrane, and phospholipase or salts thereof. According to the present invention, substances... Agent: Clark & Elbing LLP

20100227349 - Use of lymphocytes to measure anthrax lethal toxin activity: It is disclosed herein that isolated lymphocytes, such as human B-cells and CD4+ T-cell can be used to determine an amount of lymphocyte-associated anthrax lethal toxin activity present. Methods of using isolated lymphocytes to identify anthrax therapeutic agents and to determine the efficacy of a potential anthrax therapeutic are disclosed.... Agent: Klarquist Sparkman, LLP (ott-nih)

20100227352 - Expression quantification using mass spectrometry: In various aspects, the present teachings provide systems, methods, assays and kits for the absolute quantitation of protein expression. In various aspects, the present teachings provide methods of determining the concentration of one or more proteins of interest in one or more samples of interest. In various aspects, the present... Agent: Kilyk & Bowersox, P.l.l.c.

20100227353 - Rapid peptidoglycan-based assay for detection of bacterial contamination: The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (1-3)-β-D-glucan in a sample.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20100227354 - Autoimmune conditions and nadph oxidase defects: The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In particular, the invention relates to methods and materials involved in diagnosing arthritis conditions that are accompanied by an NADPH oxidase deficiency, methods and materials involved in treating, preventing, or delaying the onset of arthritis conditions... Agent: Fish & Richardson P.C.

20100227355 - reagent compositions for use in electrochemical detection: Biological reagent compositions with improved sensitivity to the concentration of blood glucose in patient samples for use in measuring systems and methods. The reagent compositions comprise a glucose oxidoreductase enzyme, a flavin nucleoside coenzyme and a mediator formulation. The mediator formulation comprises at least one electroactive organic molecule and at... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100227357 - Fungal isolates and their use to confer salinity and drought tolerance in plants: The present invention is directed to methods and compositions of endophytic fungi that confer stress tolerance to inoculated plants, including both monocots and dicots. In particular, Fusarium species, isolated from the dunegrass, Leymus mollis, growing in plant communities on Puget Sound beaches of Washington State. Upon inoculating a target plant... Agent: Cooley LLP Attn: Patent Group

20100227356 - Methods for assessing effects on skeletal growth: A method for assessing effects on growth of skeletal members comprises preparing a culture comprising a skeletal member and a substance whose effect on growth of the skeletal member is to be determined and capturing images of the skeletal member at selected time intervals without terminating growth. The skeletal member... Agent: Carestream Health, Inc. Attn: Patent Legal Staff

20100227358 - Mineralized three-dimensional bone constructs: The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture... Agent: Greenberg Traurig, LLP

20100227360 - Salmonella selective enrichment medium containing tetrathionate and magnesium salt: The invention relates to a salmonella selective enrichment medium containing tetrathionate or a salt thereof and at least one type of magnesium salt and to a method for detecting salmonella in a sample by using said selective enrichment medium.... Agent: Alston & Bird LLP

20100227359 - System and method for detection of substances: A system, a method, and apparatus for determining the presence of an agent in a sample. The system includes a sampler for collecting the sample, and an attachment means for attaching the sampler to the sample. In addition, the system includes a carrier, wherein the sampler with the sample is... Agent: Seyfarth Shaw LLP

20100227362 - novel ylmpo1 gene derived from yarrowia lipolytica and a process for preparing a glycoprotein not being mannosylphosphorylated by using a mutated yarrowia lipolytica in which ylmpo1 gene is disrupted: The present invention relates to a novel YlMPOl gene which plays an important role in mannosylphosphorylation of an industrial yeast Yarrowia lipolytica, and to a method for preparing a host system capable of producing recombinant glycoproteins free of mannosylphosphate by disruption of the gene. The mannosylphosphorylation is suppressed by the... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100227363 - Alg3 mutant: The present invention relates to a method to produce proteins reduced in high mannose type glycans in a plant or plant cell by partially inhibiting the expression of the Alg3 gene in said plant or plant cell. Said partial inhibition can be provided for by inserting the Alg3 mutant gene... Agent: Hoffmann & Baron, LLP

20100227361 - Host cell modifications that improve peptide production and downstream processing: Disrupting the expression of endogenous Escherichia host cell genes gcvA and spr provides mutant host cells having increased heterologous peptide production. The addition of a genetic modification to the coding region of gene yejM further enhances peptide production and facilitates easier downstream processing. Recombinant Escherichia host cells are provided as... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100227364 - Novel lipolytic enzyme elip: The present invention provides a novel nucleic acid sequence, designated ELIP, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for... Agent: Janet Kaiser Castaneda Genencor International, Inc.

20100227365 - Methods of using isolated glucose isomerase: This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid variation including phenylalanine (Phe) at position 139, alanine (Ala) at position 182, serine (Ser) at position 187, and glutamine (Gin) at... Agent: The Webb Law Firm, P.C.

20100227366 - Method of producing polysaccharides from coffee beans or/and coffee extraction residue: A process for efficiently producing a polysaccharide from coffee beans or/and a coffee extraction residue. Use of these has not received attention because of difficulty in decomposing these. The process, which is for producing a polysaccharide from coffee beans or/and a coffee extraction residue, comprises: a step (a) in which... Agent: Sughrue Mion, PLLC

20100227367 - Process of producing a fermentation product: The invention relates to a process for producing a fermentation product from molasses wherein molasses is i) treated with a combination of alpha-amylase and glucoamylase and ii) fermented using one or more fermenting organisms at a cell count in the range from 107-1010 cells/mL fermentation medium.... Agent: Novozymes North America, Inc.

20100227368 - Renewable energy system: A renewable energy system and related process includes a biomass unit for receiving biomass energy sources, e.g., municipal wastes, used tires and wood waste. The biomass is fed to a power plant which produces electricity and steam which are fed to several units of the system. A bio-diesel unit uses... Agent: The Webb Law Firm, P.C.

20100227369 - System for fermentation of biomass for the production of ethanol: A biorefinery and a system for producing a fermentation product from biomass are disclosed. The biorefinery comprises a preparation system to prepare the biomass into prepared biomass; a pre-treatment system to pre-treat the prepared biomass with a dilute acid for separation into a first component from which pentose can accessed... Agent: Womble Carlyle Sandridge & Rice, PLLC

20100227370 - Method of producing lycopene using recombinant esherichia coli: A method of producing lycopene, with high productivity by means of a recombinant bacterial strain includes preparing the recombinant vector containing genes encoding proteins, which are required for lycopene biosynthesis. The genes involved in lycopene biosynthesis are crtE, crtB and crtI, and at least one of the said three genes... Agent: Dority & Manning, P.A.

20100227371 - Electrosonic cell manipulation device: In method of injecting a substance into a living cell having a cell membrane, the substance, the cell and a liquid are placed into a tapering passage. Energy is applied to the cell, thereby inducing poration. To sort cells, a cellular suspension is placed in a tapering passage, including a... Agent: Bryan W. Bockhop, Esq. Bockhop & Associates, LLC

20100227372 - Biological functionalisation of substrates: The invention relates to an activated metallic, semiconductor, polymer, composite and/or ceramic substrate, the substrate being bound through a mixed or graded interface to a hydrophilic polymer surface that is activated to enable direct covalent binding to a functional biological molecule, the polymer surface comprising a sub-surface that includes a... Agent: Amster, Rothstein & Ebenstein LLP

20100227373 - Recombinant carrier molecule for expression, delivery and purification of target polypeptides: Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo... Agent: Fish & Richardson P.C.

20100227374 - Protein stabilization by domain insertion into a thermophilic protein: A strategy to improve protein stability by domain insertion. TEM 1 beta-lactamase (BLA) and exo-inulinase, as model target enzymes, are inserted into a hyperthermophilic maltose binding protein from Pyrococcus furiosus (PfMBP). Unlike conventional protein stabilization methods that employ mutations and recombinations, the inventive approach does not require any modification on... Agent: Smith, Gambrell & Russell

20100227375 - Polypeptides having lipase activity and polynucleotides encoding same: The present invention relates to polypeptide having lipase activity and which further has a RP of at least 0.8 and a BR of at least 1.1 at the test conditions given in the specification.... Agent: Novozymes North America, Inc.

20100227376 - Method of obtaining bacteriophage preparation: New method of removing pyrogens from bacteriophage preparations based on the natural processes of endotoxin degradation, and consisting of several stages, including in particular the addition of metal ions, the heterophase extraction, and chromatography.... Agent: Cooper & Dunham, LLP

20100227377 - Method for sustaining microorganism culture in syngas fermentation process in decreased concentration or absence of various substrates: The present invention relates to methods for sustaining microorganism culture in a syngas fermentation reactor in decreased concentration or absence of various substrates comprising: adding carbon dioxide and optionally alcohol; maintaining free acetic acid concentrations; and performing the above mentioned steps within specified time.... Agent: Ineos Usa LLC

20100227378 - Centrifugation and filtration methods for concentrating microorganisms: A process for concentrating microorganism-containing suspensions comprising (a) centrifuging a microorganism-containing suspension to provide a first microorganism-containing concentrate and a supernatant liquid; (b) filtering said first microorganism-containing concentrate, to provide a permeate and a second microorganism-containing concentrate.... Agent: Mcandrews Held & Malloy, Ltd

20100227379 - Centrifugation and filtration methods for concentrating microorganisms: Disclosed is a disk based system for separating at least two types of particulates contained in a sample fluid. The system includes a disk-like carrier board and a magnetic attraction unit. The disk-like carrier board forms at least one flow channel structure, which includes an inner reservoir, at least one... Agent: Rosenberg, Klein & Lee

20100227380 - Bioremediation: The chemical oxygen demand of unprocessed, spent metal working fluids, can be reduced to levels of 2000 mg l−1 by using a consortium of micro-organisms capable of growth in untreated semi-synthetic metal working fluids, wherein the consortium has at least four members which are selected from at least one each... Agent: Schwegman, Lundberg & Woessner, P.A.

20100227381 - Enhanced biodegradation of non-aqueous phase liquids using surfactant enhanced in-situ chemical oxidation: A method for in-situ reduction of contaminants in soil that uses chemical oxidation and biodegradation.... Agent: Venable LLP

20100227382 - Nanoscale sensors: Various aspects of the present invention generally relate to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample, and systems and methods of immobilizing entities such as reaction entities relative to nanoscale wires. In one aspect, a nucleic acid, such as DNA,... Agent: Harvard University & Medical School C/o Wolf, Greenfield & Sacks, P.C.

20100227383 - Gene detection and determination apparatus, gene reactor, and incubator: A genetic detection and determination apparatus which detects or determines genetic information, provided with a reaction container having a reaction vessel, including: a container set portion on which the reaction container is set; a moving mechanism which moves the container set portion along a track; a reaction vessel dividing portion... Agent: Staas & Halsey LLP

20100227384 - Portable genomic analyzer: An apparatus for identifying a target portion of a sample. In some embodiments, the sample can be substantially purified and/or amplified in a test chamber. In some embodiments, the sample can be provided in an amount so that amplification is not necessary. The apparatus generally comprises a test chamber having... Agent: Life Technologies Corporation C/o Intellevate

20100227385 - Method and device for measuring multiple physiological properties of cells: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing... Agent: Goodwin Procter LLP Patent Administrator

20100227386 - Compact optical detection system: A detection system is provided, the detection system comprising a light source that generates excitation light having a wavelength sufficient to excite a fluorophore in a sample; an excitation filter positioned along a first line along a path of the excitation light, the excitation filter transmitting the excitation light from... Agent: Klarquist Sparkman, LLP

20100227387 - Structure and method for handling magnetic particles in biological assays: Magnetic handling structure (1a) comprising a retractable magnet (4) and a probe (3) for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.... Agent: Paul D. Yasger Abbott Laboratories

20100227389 - Biological reactor: A biological reactor for growing a biological mass has a tank with an interior for growing the biological mass, a plate movable in a substantially vertical direction and an interior of the tank, and a valve means provided with the plate and configured so that in a lower position of... Agent: L. Zborovsky

20100227388 - Reactor for growing cultures: A reactor for growing a culture has a plurality of sections located above each other in a vertical direction and each having a peripheral surface, a bottom, and a top forming together a container for accommodating a solution for growing a culture, and a plurality of light sources arranged on... Agent: L. Zborovsky

20100227390 - Ethanol water solution concentrating device: A device for concentrating ethanol from an ethanol water solution yielded from lignocellulose is equipped with a water separation membrane, an ethanol water solution storing unit and a depressurizing container provided so as to sandwich the water separation membrane, a dry gas cylinder for supplying dry gas to an ethanol... Agent: Capitol City Techlaw, PLLC

20100227391 - Device for squeezing of biological mass of cultures: A device for wringing a biological mass of cultures has a substantially vertical container having a bottom provided with a discharge opening, a rotor means located under the discharge opening and including at least two rotors which are rotatable toward one another to receive a biological mass therebetween, wherein the... Agent: L. Zborovsky

20100227394 - Fusion antibodies: The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.... Agent: Casimir Jones, S.c.

20100227393 - Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder: Methods of preparing multipotent cell populations from gallbladder are provided. Also provided are enriched multipotent cell populations from gallbladder and methods of differentiating the multipotent cell populations to prepare, for example, hepatocytes.... Agent: Hirshman Law, LLC

20100227392 - Use of rpa32, rpa4, and rpa4/rpa32 hybrid polypeptides and polynucleotides for assessing and modulating cell proliferation: Disclosed are polynucleotides and polypeptides that are useful for assessing and modulating cell proliferation. The polynucleotides may comprise coding regions for RPA4 and RPA4/RPA32 hybrid polypeptides. The polynucleotides may be used in gene vectors for modulating cell proliferation in a patient in need thereof. Diagnostic methods related to assaying RPA4... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100227395 - Canine tumor cell and allogeneic dendritic cell fused vaccine and method for preparing the same: The present invention provides a dendritic cell-based vaccine by fusing a canine tumor cell and an allogeneic dendritic cell, and a method for preparing the same. The fusion cells expressing canine tumor antigens are generated by fusing canine bone marrow-derived dendritic cells and canine tumor cells. The canine immune system... Agent: Wpat, PC Intellectual Property Attorneys

20100227396 - Embryonic stem cell-like cells: Disclosed is a method for preparing an embryonic stem cell (ESC)-like cell, which includes the steps of: (a) obtaining a first cell population from a mammalian tissue or body fluid, wherein the first cell population comprises adult stem cells; (b) obtaining a second somatic cell population from a mammalian tissue,... Agent: Sughrue Mion, PLLC

20100227397 - Preparation method of a hair dermal papilla cell preparation, composition and method for regenerating hair follicles, and animal having regenerated hair follicles: The present invention provides a method for preparing a hair dermal papilla cell preparation comprising preparing a cell suspension by removing epidermal tissue from skin tissue and subjecting the resulting dermal tissue fraction to collagenase treatment, and cyropreserving the cell suspension to kill the follicular epidermal cells. The present invention... Agent: Fish & Richardson PC

20100227398 - Method for mixing object into gelled assembly: This invention provides a mixing method by which a mixing object can be uniformly mixed into a gelled assembly within a short time period. The method for mixing a mixing object into a gelled assembly comprises freezing the gelled assembly; melting the frozen assembly to obtain a sol; mixing the... Agent: Swanson & Bratschun, L.L.C.

20100227399 - Soft gel systems in modulating stem cell development: This invention provides gels and matrices having a rigidity in the range of 150-750 Pa, methods of manufacturing same, and method of preserving a mesenchymal stem cell population or studying mesenchymal stem cells, comprising same.... Agent: Covington & Burling, LLP Attn: Patent Docketing

20100227400 - Monomeric and dimeric fluorescent protein variants and methods for making same: The present invention relates generally to fluorescent proteins and fluorescent protein variants, and more specifically to monomeric and dimeric forms of Anthozoan fluorescent proteins. In one aspect, the present invention provides variants of fluorescent proteins, where the variants have a reduced propensity to tetramerize, and form dimeric or monomeric structures.... Agent: Townsend And Townsend And Crew, LLP

20100227401 - Media and processes for the ex vivo production of megakaryocytes from human cd34+ cells: Disclosed herein are media and processes for the ex vivo production of megakaryocytes from human CD34+ cells, in which human CD34+ cells, either being freshly isolated from a newborn's cord blood or having been subcultured in an expansion medium after isolation from a newborn's cord blood, are subjected to cultivation... Agent: The Nath Law Group

20100227402 - Cell surface coating with hyaluronic acid oligomer derivative: A method of localising reproduction assisting hyaluronic acid to reproductive cells surfaces by covalently linking it to lipids is disclosed.... Agent: Nixon & Vanderhye, PC

20100227403 - Rblif protein for use in embryonic stem cell cultures: Provided herein methods of maintaining an embryonic stem cell culture in an undifferentiated state, wherein the method includes culturing an embryonic stem cell on a rabbit feeder cell layer, wherein the rabbit feeder layer expresses a leukemia inhibitory factor (LIF) protein. Also provided are methods of maintaining an embryonic stem... Agent: Dla Piper LLP (us)

20100227404 - Water extract of antrodia camphorata for immunostimulatory effect and preparation method thereof: A preparation method for a water extract of the fruiting body of Antrodia camphorata (ACW) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract. This polysaccharide-rich water extract from A. camphorata induces the maturation... Agent: Volpe And Koenig, P.C.

20100227405 - Methods of using multilayered cell culture apparatus: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces... Agent: Corning Incorporated

20100227406 - Method for purifying cells, recovering cells, and transfecting cells gently: The present invention relates to a process for cell purification, for cell recovery from cultures and for the transfection of the cells under especially gentle conditions, where this process can additionally be coupled with subsequent isolation and purification of polynucleotides from the optionally transfected cells, and a kit and a... Agent: Fanelli Strain & Haag PLLC

20100227407 - Aav4 vector and uses thereof: The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles.... Agent: Nih-ott C/o Sheridan Ross P.C.

20100227408 - Method and apparatus for avalanche-mediated transfer of agents into cells: The present invention provides a method and apparatus for transferring an agent into a cell. The method includes the steps of providing an agent outside of a cell and generating a vapor bubble and a plasma discharge between an avalanche electrode and a conductive fluid surrounding the cell. The vapor... Agent: Wilmerhale/boston

  
09/02/2010 > patent applications in patent subcategories. class, title,number

20100221696 - Apparatus and method for maintaining and/or restoring viability of organs: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing... Agent: Oliff & Berridge, PLC

20100221697 - Composition for preserving platelets and method of using and storing the same: The present invention relates to a method for preserving and storing platelets. The method includes the steps of admixing inactivated, functional platelets with a preservative composition comprising an effective amount of one or more pharmaceutically acceptable inhibitors of platelet activation to form preserved platelets, storing the preserved platelets at low... Agent: Morris Manning Martin LLP

20100221699 - Amine-n-oxide redox indicators for fluorimetric determination of analytes: wherein R1 and R2 are each independently selected from R, (CH2CH2O)mR, COR, COOR, and OCOR; each R3 is independently selected from NO2, CN, R, OR, OCOR, COOR, SR, and halogen; R is H or C1-C4 alkyl, where alkyl is optionally substituted with one or more functional group independently selected from... Agent: Dinsmore & Shohl, LLP Fifth Third Center

20100221698 - In-vitro deposition evaluation method for identifying personal care compositions which provide improved deposition of benefit agents: The present invention relates to an in-vitro deposition evaluation method and an system for evaluating deposition of personal care compositions. The method comprises the steps of providing a microplate and at least one body that is capable of movement within the plurality of wells of the microplate. The method comprises... Agent: The Procter & Gamble Company Global Legal Department - Ip

20100221700 - Method of monitoring hiv infection: The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a method of monitoring the intensity of HIV infection and predicting the time to progression to acquired immunodeficiency syndrome (AIDS).... Agent: Nixon & Vanderhye, PC

20100221701 - Versatile thermal detection: The present application discloses a method of detecting hybridization of complementary segments of nucleic acids by a heat generated upon aforementioned hybridization, a method of detecting the presence of a predetermined reactant in a sample suspected of containing the same, a method of detecting complex responses occur in biological systems... Agent: Yoram Tsivion

20100221714 - Analysis and use of par1 polymorphisms for evaluating the risk of cardiovascular disease: The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furthermore relates to methods for detecting said genetic variations for the purpose of patient diagnosis.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100221710 - Assays for fungal infection: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal... Agent: Foley And Lardner LLP Suite 500

20100221733 - Biomarker of allergic disease and use of the same: A biomarker is provided for an allergic disease caused by an allergic reaction that is caused not exclusively by histamine release, such as pruritus, and use of the same. Use of Granzyme A as a biomarker makes it possible to provide an indication for chronic itching skin disease, for which... Agent: Alston & Bird LLP

20100221712 - Cell-mediated immune response assay and kits therefor: The present invention provides methods and kits for measuring a cell-mediated immune (CMI) in a small volume of whole undiluted blood collected from a subject. In particular, the methods are for measuring responses in undiluted whole blood samples having a volume of, for example, 50 μl to 500 μl. Thus,... Agent: Seed Intellectual Property Law Group PLLC

20100221703 - Chemiluminescence proximity nucleic acid assay: This invention relates to the detection and quantitation of target nucleic acids in a heterogeneous mixture in a Sample and the methods of use thereof. The detection system includes a chemiluminescent molecule, a chemiluminescent substrate, a dye that is light responsive when intercalated into nucleic acids and nucleic acids. This... Agent: Swanson & Bratschun, L.L.C.

20100221716 - Classification of nucleic acid templates: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary... Agent: Pacific Biosciences Of California, Inc.

20100221715 - Detection of bordetella: The invention provides methods to detect Bordetella pertussis and/or Bordetella parapertussis in a biological sample. Primers and probes for the differential detection of B. pertussis and B. parapertussis are provided by the invention. Articles of manufacture containing such primers and probes for detecting B. pertussis and/or B. parapertussis are further... Agent: Fish & Richardson P.C.

20100221707 - Diagnostic methods for detecting congenital bone defects: The present disclosure is directed to compositions and methods for screening for patients at risk for autosomal recessive hypophosphatemic rickets. More particularly, diagnostic reagents and procedures are provided for analyzing samples to detect defective DMP1 expression.... Agent: Barnes & Thornburg LLP

20100221735 - Diagnostic test for parkinson's disease: The present invention relates to molecular markers for detection, prognosis and follow up of Parkinson's disease (PD), wherein said molecular markers are one or more genes with altered expression pattern, or gene products thereof (RNA or protein). Genes which expression is upregulated or downregulated in PD patients are tools for... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100221713 - Droplet actuator devices, systems, and methods: The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one application, droplet actuators are used to conduct genetic analysis using polymerase chain reaction (PCR) techniques. The invention addresses the need... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20100221723 - Early detection of cancer by methylated dna in blood: This invention relates to early detection of cancer by detecting methylated DNA in blood. In one embodiment, there is provided a method of predicting the occurrence of hepatocellular carcinoma in a subject, comprising the steps of preparing DNA samples from blood samples of the subject; and determining methylation status of... Agent: Law Offices Of Albert Wai-kit Chan, PLLC

20100221705 - In situ hybridization detection method: The invention provides compositions and methods for the detection of targets in a sample; in particular, an in situ hybridization (ISH) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100221706 - Kit for the amplification of nucleic acids: A ready-to-use kit for the PCR amplification of nucleic acids is described, comprising at least one vessel into which a master mix comprising the salts, the buffer and the deoxynucleotide triphosphates required for the PCR amplification is prealiquotted, the said master mix being mixed with an effective amount of an... Agent: Steinfl & Bruno

20100221718 - Method and rapid test for detection of specific nucleic acid sequences: A universally usable method for specific detection of target nucleic acid sequences, which method can be performed very rapidly and also simply and furthermore which does not need any expensive instrumental systems. The method is intended to be suitable as a molecular genetic rapid test and to respect the requirements... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100221708 - Method for chromosome enumeration: A method of sample analysis is provided. The method comprises: a) contacting a genomic sample comprising a plurality of intact chromosomes, i.e., metaphase or interphase chromosomes, with a first set of labeled oligonucleotide probes under in situ hybridization conditions to produce a contacted sample comprising labeled chromosomes, where i. each... Agent: Agilent Technologies Inc.

20100221736 - Method for predicting susceptibility to a mental disorder: This invention relates generally to the field of mental disorders and, in particular, to a method for predicting susceptibility to a mental disorder, or a mental associated disorder.... Agent: Harness, Dickey & Pierce, P.L.C

20100221728 - Method for quantifying initial concentration of nucleic acid from real-time nucleic acid amplification data: Provided is a method for quantifying an initial concentration of a nucleic acid from a real-time nucleic acid amplification data. Nucleic acid (DNA or RNA) extracted from organism or virus is amplified using an enzyme. Then, the initial concentration of the nucleic acid is found by calculating the characteristic amplification... Agent: Cantor Colburn, LLP

20100221738 - Method of diagnosis of a predisposition to develop thrombotic disease and its uses: The present invention refers to a method of diagnosis of a predisposition to develop thrombotic disease, to test systems and their use for the diagnosis of a predisposition to develop thrombotic disease, to a P2X1 promoter variant and its use for screening for an anti-thrombotic agent, and to methods for... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100221704 - Method of dispensing nonvolatile liquid in reaction vessel and reaction vessel processing apparatus: It is intended to easily dispense a minute amount of nonvolatile liquid. In a preferred embodiment, in dispensing of mineral oil (nonvolatile liquid), dispensing is conducted in the condition that the amount of air contained in a tip (70) is small by aspirating a larger amount of mineral oil (40)... Agent: Cheng Law Group, PLLC

20100221732 - Methods and compositions for evaluating chronic immune diseases: Methods and compositions are provided for evaluating a subject for chronic immune disease, including predicting whether a subject is susceptible to a chronic immune disease, diagnosing whether a subject has a chronic immune disease and/or determining a treatment for a subject suffering from a chronic immune disease. Aspects of the... Agent: Bozicevic, Field & Francis LLP

20100221729 - Methods for assessing calpain 2 resistance, disease progression, and treatment efficacy in ovarian cancer: The invention provides methods for predicting whether an ovarian cancer patient's tumor will be resistant to chemotherapy. The invention also provides methods for monitoring the effectiveness of treatment, particularly a chemotherapeutic treatment, in a patient treated for ovarian cancer. The invention further provides methods for treating ovarian cancer, by reducing... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100221731 - Methods for assessing metap2 resistance, disease progression, and treatment efficacy in ovarian cancer: The invention provides methods for predicting whether an ovarian cancer patient's tumor will be resistant to chemotherapy. The invention also provides methods for monitoring the effectiveness of treatment, particularly a chemotherapeutic treatment, in a patient treated for ovarian cancer. The invention further provides methods for treating ovarian cancer, by reducing... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100221730 - Methods for assessing sparc resistance, disease progression, and treatment efficacy in ovarian cancer: The invention provides methods for predicting whether an ovarian cancer patient's tumor will be resistant to chemotherapy. The invention also provides methods for monitoring the effectiveness of treatment, particularly a chemotherapeutic treatment, in a patient treated for ovarian cancer. The invention further provides methods for treating ovarian cancer, by reducing... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100221702 - Methods for detection and typing of nucleic acids: Disclosed are methods and kits for identifying and characterizing polynucleotide sequences in a sample which may include a heterogeneous sample. Some of the methods and kits are directed to the identification and characterization of a virus in a sample, which may include HIV capable of cause AIDS or AIDS-like symptoms.... Agent: Foley & Lardner LLP

20100221722 - Methods for evaluating breast cancer prognosis: Methods for diagnosing and for evaluating the prognosis of a cancer patient, particularly a breast cancer patient, are provided. The methods include determining expression levels of at least five biomarkers in a body sample including a cancer cell from the patient, where expression levels of the biomarkers are indicative of... Agent: Alston & Bird LLP

20100221709 - Methods for identifying agents that modulate apoptosis in cells that over-express a bcl-2 family member protein: The present invention provides methods and combinations of methods for identifying agents that modulate the apoptotic state of a cell by binding to the hydrophobic groove of a Bcl-2 family member anti-apoptotic protein. In certain embodiments, the methods generally comprise the use of Bcl-2 family member proteins having one or... Agent: Townsend And Townsend And Crew, LLP

20100221717 - Methods, compositions, and kits for detecting allelic variants: In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions... Agent: Life Technologies Corporation C/o Intellevate

20100221724 - Patched polypeptides and uses related thereto: Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The patched and hedgehog genes are useful in creating... Agent: Ropes & Gray LLP

20100221720 - Plant artificial chromosomes, uses thereof and methods of preparing plant artificial chromosomes: Methods for preparing cell lines that contain plant artificial chromosomes, methods for preparation of plant artificial chromosomes, methods for targeted insertion of heterologous DNA into plant artificial chromosomes, and methods for delivery of plant chromosomes to selected cells and tissues are provided. In particular, plant artificial chromosomes that are substantially... Agent: K&l Gates LLP

20100221719 - Probes for detecting protein nuclear transport and method for detecting and quantifying protein nuclear transport using the same: A convenient and highly accurate method for detecting protein nuclear transport induced by an endogenous or exogenous substance in local areas of living cells or animals is provided. The method uses a pair of probes for detecting protein nuclear transport, comprising Probe I and Probe II. In Probe I, a... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100221725 - Real time gene expression profiling: The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herein provide methods for monitoring the amplification of one sequence or... Agent: Mark J. Fitzgerald

20100221726 - Relating to devices: A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the... Agent: Merchant & Gould PC

20100221711 - Respiratory syncytial virus (rsv) viral load detection assay: The invention concerns a method for the extraction of nucleic acids from biological samples e.g. tissue material or sputum derived from human or animal species and the quantitative detection thereafter of said nucleic acids e.g. in terms of viral load, more specifically RSV viral load detection.... Agent: Philip S. Johnson Johnson & Johnson

20100221734 - Shotgun dna mapping by unzipping: The present invention provides a method of mapping a nucleic acid molecule such as, for example, DNA. Generally, the method includes providing a nucleic acid molecule comprising an unzipping force; comparing the unzipping force of the nucleic acid molecule to unzipping forces of a plurality of reference nucleic acid molecules,... Agent: Mueting, Raasch & Gebhardt, P.A.

20100221727 - Site-specific enzymatic deposition of metal in situ: The present invention provides compositions, kits, assembles of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention relates to use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also... Agent: Hayes Soloway P.C.

20100221739 - Suppression of tla1 gene expression for improved photosynthetic productivity: The invention provides method and compositions to minimize the chlorophyll antenna size of photosynthesis by decreasing TLA1 gene expression, thereby improving solar conversion efficiencies and photosynthetic productivity in plants, e.g., green microalgae, under bright sunlight conditions.... Agent: Townsend And Townsend And Crew, LLP

20100221721 - System for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: The Invention Science Fund Clarence T. Tegreene

20100221737 - Translocation and mutant ros kinase in human non-small cell lung carcinoma: In accordance with the invention, a novel gene translocation, (5q32, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of CD74 with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The CD74-ROS fusion protein is anticipated to drive the... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100221745 - Abnormal prion protein binder, and method for detection of abnormal prion protein: Disclosed are: a method for detecting pathogenic isoform of prion protein as distinguished from normal prion protein in a simple manner, rapidly, with a high degree of sensitivity and quantitatively without the need of the enzymatic treatment with protease K; and a reagent for use in the method. Specifically disclosed... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100221741 - Analysis device, and analysis apparatus and method using the same: An analysis device includes: a separation cavity 18 for separating a test liquid into a solution component and a solid component by using a centrifugal force; a higher specific gravity component quantitative cavity 23 for holding a portion of the separated solid component which has been transferred; a sample solution... Agent: Hamre, Schumann, Mueller & Larson P.C.

20100221746 - Compositions and methods for the treatment of disease: The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of disease associated with fibrosis in a vertebrate, said composition comprising at least one activin antagonist, and optionally a pharmaceutically acceptable carrier, adjuvant and/or diluent. The invention also relates to methods of treatment of disease associated with fibrosis... Agent: Alston & Bird LLP

20100221744 - Method for prediction of postoperative prognosis and diagnosis kit: The present invention relates to a method for predicting the postoperative prognosis of a lung adenocarcinoma patient with high sensitivity and/or specificity by identifying a protein with an expression level that specifically varies in a lung adenocarcinoma patient, comprising: step (a) of determining expression levels of myosin IIA and/or vimentin... Agent: Birch Stewart Kolasch & Birch

20100221743 - Methods for diagnosing and treating endoplasmic reticulum (er) stress diseases: The present invention provides methods and reagents to quantify endoplasmic reticulum stress (ER stress) levels, and methods and compounds for treating ER stress disorders such as diabetes. Methods for quantifying ER stress in mammalian cells are exemplified.... Agent: Fish & Richardson PC

20100221740 - Methods, immunoassays and devices for detection of anti-lipoidal antibodies: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a solid support (such as a nitrocellulose membrane) is described. The ability to immobilize a... Agent: Klarquist Sparkman, LLP

20100221742 - Novel cancer associated antibodies and their use in cancer diagnosis: The present invention relates to an antibody having specificity for a polypeptide comprising an amino acid sequence of SEQ ID No:2 or an isoform thereof or a polypeptide comprising SEQ ID NO:2.... Agent: Merchant & Gould PC

20100221751 - Method of screening endothelial cells for angiogenic capability: Provided is a method of screening a primary endothelial cell population for angiogenesis capability comprising: (a) measuring the percentage of cells that are positive for VEGF R2 and CD34, the level of VEGF R2, or measuring the VEGF R2 to VEGF R1 ratio in the population; and (b) selecting those... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100221753 - Prostate cancer-related compositions, methods and kits based on dna macroarray proteomics platforms: The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates to methods of detecting and treating prostate cancer, comprising modulating or detecting PCADM-1... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100221752 - Ovarian cancer biomarkers and uses thereof: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of ovarian cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose ovarian cancer or permit the differential diagnosis of a pelvic mass as benign... Agent: Swanson & Bratschun, L.L.C.

20100221754 - Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators: EGFR biomarkers useful in a method for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) measuring in the mammal the level of at least one biomarker selected from epiregulin and amphiregulin, (b)... Agent: Louis J. Wille Bristol-myers Squibb Company

20100221756 - Allergy test based on flow cytometric analysis: The invention pertains to a method for the determination of basophil activation induced by a test substance by flow cytometric measurement of the changes of the mean or median fluorescence intensities (WI) of the basophilic FcεRI receptor present on the cell surface of basophils (MFI-FcεRI) and/or the IgE antibodies bound... Agent: Millen, White, Zelano & Branigan, P.C.

20100221755 - Use of antibody secreting cell elispot to assess antibody responses following antigen exposure: Disclosed are methods and kits for early detection of antigen exposure through the presence or absence of antigen-specific antibodies.... Agent: Ballard Spahr LLP

20100221757 - Patient sample classification based upon low angle light scattering: An apparatus for classifying a liquid patient sample includes at least one sample container having a quantity of a sample that is aggressively acted upon so as to create a flow field. A measurement mechanism includes at least one low angle light emitter aligned with a measurement window of the... Agent: Hiscock & Barclay, LLP

20100221758 - Sensors for measuring contaminants: The present invention provides biosensors and methods of use for detecting the presence or absence of mycoplasma contamination through the detection of hydrolytic enzymes that are conserved among Mycoplasma species. Such hydrolytic enzymes include, but are not limited to, proteases, reductases and nucleases.... Agent: Mirick, O'connell, Demallie & Lougee, LLP

20100221748 - Ampk modulation as a method of regulating stem cell and cancer stem cell proliferation, self-renewal and differentiation: Methods are disclosed for decreasing stem cell proliferation, including cancer stem cell proliferation. These methods comprise administering to stem cells inhibitors of AMP activated protein kinase (AMPK). Methods for promoting stem cell growth by increasing stem cell proliferation, self-renewal and/or differentiation are also disclosed. These methods comprise administering AMPK activators... Agent: Zackson Law LLC

20100221747 - Immunochromatography detection of multidrug-resistant staphylococcus and diagnostic kit: It is intended to provide an immunochromatographic detection device which detects PBP2′ specifically produced by a multidrug-resistant Staphylococcus bacterium by an immunochromatographic detection method sensitively, simply and rapidly and is capable of determining infection with a multidrug-resistant Staphylococcus, a diagnostic method using the detection device, and a diagnostic kit including... Agent: Foley And Lardner LLP Suite 500

20100221749 - Three-functional pseudo-peptidic reagent, and uses and applications thereof: The invention relates to a three-functional pseudo-peptidic reagent, to the various uses thereof, in particular for preparing bioluminescent reagents or optionally luminescent bio-conjugates, to the use of said reagents and bio-conjugates for functionalising solid substrates, and to the use of solid substrates thus functionalised in the detection of molecules of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100221750 - Methods and compositions for risk stratification: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20100221759 - Assay for the diagnosis of alzheimer's disease based on the determination of the ratio of gamma-secretase abeta cleavage products: Described is a method for the diagnosis of Alzheimer's disease (AD) or a particular stage of the disease which is based on the determination of the ratio of at least two gamma-secretase cleavage products, Abeta48, Abeta45, Abeta42, Abeta38 and Abeta35, preferably the ratio of Abeta38: Abeta42. A decreased ratio of... Agent: Proskauer Rose LLP

20100221761 - Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using elisa assays: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic... Agent: Fulbright & Jaworski L.L.P.

20100221760 - Methods and compositions for detecting and quantifying sappbeta: The present invention provides methods (assays) for detecting and/or quantifying sAPPβ, a secreted β-secretase (BACE1) cleavage fragment of the β-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPPβ and... Agent: Baker Botts L.L.P.

20100221762 - Method and apparatus for determining an analyte concentration in a sample having interferents: A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of... Agent: Knobbe Martens Olson & Bear LLP

20100221763 - Specific acceptors for transferases to saccharides and method for obtaining and using same: m

20100221764 - Novel nitroreductase enzymatic substrates:

20100221768 - Cell culture dish: An object of the present invention is to provide a culture dish appropriate for automatically identifying cultured cells. The present invention relates to a culture dish for culturing cells that require separate control, which has a bottom wall and a side wall, wherein cell-holding parts having wells are arranged on... Agent: Sughrue Mion, PLLC

20100221767 - Diagnostic method and prognostic tool for osteoarthritis: The invention relates to a diagnostic method and prognostic tool for osteoarthritis and uses thereof.... Agent: Mccarthy Tetrault LLP

20100221769 - Electroporative flow cytometry: Novel devices and methods are provided, which include electroporative flow cytometry, where electroporation is combined with flow cytometry. The devices and methods can be used for the detection a variety of cellular features, including protein translocation, and for monitoring biomechanics at single cell level. Using the novel devices methods it... Agent: Brinks Hofer Gilson & Lione

20100221770 - Methods for detecting and analyzing n-glycolylneuraminic acid (neu5gc) in biological materials: The present application is in the field of sialic acid chemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of the non-human sialic acid, N-glycolylneuraminic acid (Neu5Gc) in biological materials, such as food and clinical specimens. Such detection and analysis is facilitated by the... Agent: Peter G. Carroll Medlen & Carroll, LLP

20100221765 - Microtube reader device for the analysis of blood samples: The invention comprises taking colour pictures of back-lighted analysis microtubes and using the colour information in the images to identify areas of the image which are relevant for interpreting the result of other possible artefacts, as well as detecting abnormal samples and/or reactions characterised by changes in the colour properties... Agent: Buchanan, Ingersoll & Rooney PC

20100221766 - Nuclear transfer promoter for cdc42 protein and method of screening the same: A nuclear transfer promoter for Cdc42 protein comprising an isoprenoid synthesis inhibitor and/or a geranylgeranyl transferase inhibitor such as an HMG-CoA synthase inhibitor, an HMG-CoA reductase inhibitor, an AMPK activator or a farnesyl pyrophosphoric acid synthase preparation; utilization thereof; a method therefor; a blood vessel remedy comprising the nuclear transfer... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100221771 - Serum-free growth medium for acholeplasma laidlawii and methods for retention testing sterilizing grade filters: A method for retention testing sterilizing grade filters comprises: a) providing a stock of Acholeplasma laidlawii; b) growing up the stock of A. laidlawii for about 24 hours or less in a single serum-free growth medium that supports cell growth to a high titer and yields a cellular morphology where... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100221772 - Automated cell density adjustment method for producing an analysis plate: allowing the solution to decant in order to obtain a thin layer of cells on the analysis plate (4). It includes a step of measuring the cell density of the sampled solution, the measurement being carried out in the decantation chamber (2). A device for producing a cell analysis plate... Agent: Young & Thompson

20100221777 - Designer ligands of tgf-beta superfamily: The present disclosure relates to chimeric polypeptide having TGF-beta activity, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100221775 - Increased production of secreted proteins by recombinant eukaryotic cells: Described herein are methods for increasing the amount of protein secreted by a cell. In one case, a cell is provided which contains a heterologous nucleic acid encoding a protein having unfolded protein response modulating activity and a heterologous nucleic acid encoding a protein of interest to be secreted. In... Agent: Danisco US Inc. Attention: Legal Department

20100221774 - Methods to obtain recombinant proteins with increased sialylation from cells that express adenovirus e1a protein, and proteins obtained thereby: Provided are compositions comprising one or more isoforms of an erythropoietin (“EPO”) comprising glycans linked thereto, wherein the glycans have Lewis x structures and on average at least six sialic acid moieties per EPO molecule. Further provided are methods for obtaining a composition comprising one or more isoforms of EPO... Agent: Traskbritt, P.C.

20100221780 - Modified variant bowman birk protease inhibitors: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing... Agent: Danisco US Inc. Attention: Legal Department

20100221778 - Novel lignin-resistant cellulase enzymes: Provided are modified cellulase enzymes exhibiting increase cellulose-hydrolyzing activity in the presence of lignin and/or reduced binding to lignin comprising modified linker peptides comprising one or more amino acid substitutions, insertions, or deletions that result in (a) a decrease in the calculated isoelectric point of the linker peptide and/or (b)... Agent: Fitzpatrick Cella Harper & Scinto

20100221773 - Nucleic acids encoding a functional mammalin purinoreceptor, p2x3, methods of production and use thereof: The subject invention relates to the rhesus monkey P2X3 receptor, nucleic acids encoding this receptor, methods of modulating the activity of a target purinergic receptor using the P2X3 receptor and to uses of these methods. In particular, such methods may be used, for example, to accelerate the rate of resensitization... Agent: Merck

20100221779 - Phytases, nucleic acids encoding them and methods for making and using them: The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from recombinant host cells. The phytases of the invention can be used to aid in the digestion of phytate where... Agent: Verenium Corporation Intellectual Property Department

20100221776 - Process for the fermentative production of heterologous proteins by means of escherichia coli: A process for producing a heterologous protein is provided. The process comprises culturing an E. coli strain in a fermentation medium, the E. coli strain harboring a gene which codes for the heterologous protein and is functionally linked to a signal sequence coding for a signal peptide, and releasing the... Agent: Brooks Kushman P.C.

20100221781 - Cho-k1 cell line: The current invention reports a CHO-K1 cell, characterized in that said CHO-K 1 cell is derived from CHO-K1 cell deposited as ATCC CCL-61, grows in suspension, requires no glutamine, no insulin, and no growth factors in the cultivation medium for growth, whereby said CHO-K1 cell is not modified compared to... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100221782 - Modified chimeric polypeptides with improved pharmacokinetic properties: Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides... Agent: Regeneron Pharmaceuticals, Inc

20100221783 - Expression cloning method suitable for selecting library clones producing a polypeptide of interest: The present invention relates to methods for producing a recombinant polypeptide of interest, the method comprising the steps of: a) providing a polynucleotide library encoding one or more polypeptides of interest, wherein the library was prepared in an expression cloning vector comprising at least the following elements: i) a polynucleotide... Agent: Novozymes North America, Inc.

20100221784 - Beta-glucosidase enhanced filamentous fungal whole cellulase compositions and methods of use: The present disclosure provides beta-glucosidase enhanced filamentous fungal whole cellulase compositions. Also provided are methods of hydrolyzing a cellulosic material with beta-glu-cosidase enhanced whole cellulase compositions. The present disclosure further provides methods of decreasing the amount of a whole cellulase required to hydrolyze a cellulosic material by adding an effective... Agent: Danisco US Inc. Attention: Legal Department

20100221786 - Cyclic reverse transcription method: Disclosed is a cyclic reverse transcription method, which comprises performing reverse transcription reaction in one or more cycles, each cycle comprising the steps of: (i) performing reaction with a reverse transcription reaction solution comprising template RNA, RNA-dependent DNA polymerase, a reaction buffer, primers for reverse transcription and dNTPs, and optionally,... Agent: Clark & Brody

20100221787 - Isothermal amplification method and dna polymerase used in the same: (X) a primer that contains, in a 3′ end portion, a sequence (Ac′) that hybridizes to a sequence (A) of a 3′ end portion of the target nucleic acid sequence and also contains, on a 5′ side of the sequence (Ac′), a sequence (B′) that hybridizes to a complementary sequence... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100221785 - Isothermal strand displacement amplification using primers containing a non-regular base: The invention is directed to a method for isothermal DNA amplification comprising providing to the DNA to be amplified an amplification mix comprising a first primer at least partially complementary to a region of DNA and containing a non-regular base, a second primer at least partially complementary to a region... Agent: Knobbe Martens Olson & Bear LLP

20100221790 - Analyzing messenger rna and micro rna in the same reaction mixture: The present teachings provide methods, compositions, and kits for performing primer extension reactions on at least two target polynucleotides in the same reaction mixture. In some embodiments, a reverse transcription reaction is performed on a first target polynucleotide with a hot start primer comprising a self-complementary stem and a loop,... Agent: Life Technologies Corporation C/o Intellevate

20100221789 - High potency sirnas for reducing the expression of target genes: The present invention provides improved methods of attenuating gene expression through the phenomenon of RNA interference. The invention provides methods of synthesis of double stranded RNAs (dsRNAs) of increased potency for use as small interfering RNA (siRNA). Surprisingly and unexpectedly, siRNAs made by the methods of the invention are significantly... Agent: Life Technologies Corporation C/o Intellevate

20100221791 - Method for incorporating proteins into lentivirus vectors: The present invention is a method for incorporating an integrase-fusion protein into a third-generation lentivirus vector, comprising: (i) transfecting a vector packaging plasmid into a producer cell, wherein the vector packaging plasmid contains a lentivirus transfer construct and a gene encoding the integrase-fusion protein, said gene being fused to the... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100221788 - Method for recovering short rna, and kit therefor: e

20100221792 - Method for producing an l-amino acid: An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which is able to produce the L-amino acid, and is modified so that the activity of ribonuclease G is decreased in a medium containing glycerol as the carbon source, and collecting the L-amino acid from the... Agent: Cermak Nakajima LLP Acs LLC

20100221793 - Method for producing beta-amino acid: Disclosed is a method for producing a β-amino acid comprising a step of synthesizing a β-amino acid from an α-amino acid in the presence of an amino acid aminomutase. In this method, a β-amino acid is precipitated as a solid in the reaction solution.... Agent: Buchanan, Ingersoll & Rooney PC

20100221794 - A new method for producing eritadenine in liquid phase fermentation: Method to produce eritadenine by liquid phase fermentation of Lentinus edodes without formation of the fruit body wherein the Lentinus edodes is exposed to shear during its cultivation.... Agent: Venable LLP

20100221796 - Novel carbamoylglycine derivatives: The present invention relates to carbamoylglycine derivatives, a process for the preparation of carbamoylglycine derivatives and the use of carbamoylglycine derivatives in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel carbamoylglycine... Agent: Nixon & Vanderhye, PC

20100221795 - Novel oxidase gene and method for producing 3-indole-pyruvic acid by utilizing the gene: It is an object of the present invention to provide a procedure for realizing inexpensive and simple production of 3-indole-pyruvic acid. A transformant is made using a polynucleotide having a specific nucleotide sequence encoding a protein having an oxidase activity, and oxidase is generated by culturing the transformant in a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100221797 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20100221798 - Methods and compositions for producing hydrocarbons: Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.... Agent: Wilmerhale/boston

20100221799 - Reductase, gene thereof and method of using the same: The present invention relates to a protein which can asymmetrically reduce an ortho-substituted phenylglyoxalic acid compound to industrially advantageously produce an amide or ester compound of corresponding optically-active ortho-substituted mandelic acid, a DNA encoding the protein, a process for producing the protein from the DNA, and a process for asymmetrically... Agent: Sughrue Mion, PLLC

20100221800 - Microorganism engineered to produce isopropanol: Provided herein are metabolically-modified microorganisms useful for producing biofuels.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100221802 - Method for producing butanol using two-phase extractive fermentation: A method of making butanol from at least one fermentable carbon source that overcomes the issues of toxicity resulting in an increase in the effective titer, the effective rate, and the effective yield of butanol production by fermentation utilizing a recombinant microbial host wherein the butanol is extracted into specific... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100221801 - Yeast with increased butanol tolerance involving a multidrug efflux pump gene: Increasing tolerance to butanol in yeast has been accomplished by decreasing activity of Pdr5p encoded by an endogenous PDR5 gene. A deletion mutation of the PDR5 gene led to improved growth yield in the presence of butanol. Yeast cells with reduced Pdr5p activity, or other multidrug resistance ATP-binding cassette transporter... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100221803 - Material conversion method using cellulose-based biomass: It is an object of the present invention to develop a conversion method for easily obtaining a useful substance such as ethanol from a cellulose-based biomass at a good yield via enzyme reaction and microbial fermentation. It has been found that the conversion efficiency can be increased with the use... Agent: Lucas & Mercanti, LLP

20100221804 - Biogas apparatus and biogas production process for integration with an ethanol production system and process: An integrated system produces ethanol and biogas from raw plant materials. The system includes a pretreatment apparatus for converting raw plant materials into sugars and a fermenter for fermenting the sugars to produce a beer including ethanol. A distillation apparatus separates the beer into the ethanol and a whole stillage,... Agent: Drinker Biddle & Reath LLP Attn: Patent Docket Dept.

20100221805 - Methods for producing fermentation products: The invention relates to methods for producing a fermentation product from a lignocellulose-containing material comprising: i) pre-treating lignocellulose-containing material; ii) introducing pre-treated lignocellulose-containing material into medium comprising fermentable sugars derived from starch-containing material; ii) fermenting using a fermenting organism.... Agent: Novozymes North America, Inc.

20100221806 - Apparatus and method for growing plants, a biomass, or microrganisms in water through photosynthesis: Presented is an apparatus for growing plants, a biomass, or a microorganism through photosynthesis. The apparatus includes a hollow tube-like structure of flexible transparent material having a first end, a second end, and a middle section, and defining an interior for receiving, through one of the ends, an aqueous solution,... Agent: Daniel J Swirsky

20100221807 - Cellulase enzyme and method for producing the same: This invention provides a cellulase enzyme derived from intestinal symbiotic protists of insects selected from the group consisting of Reticulitermes speratus, Hodotermopsis sjostedti, Neotermes koshunensis, Mastotermes darwiniensis, and Cryptocercidae and comprising an amino acid sequence encoded by a nucleotide sequence selected from the group consisting of the nucleotide sequences as... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100221808 - Polysialic acid derivatives: A polysialic acid compound is reacted with a hetero-bifunctional reagent to introduce a pendant functional group for site-specific conjugation to sulfhydryl groups, for instance side chains of cysteine units in drugs, drug delivery systems, proteins or peptides. The functional group is, for instance, an N-maleimide group.... Agent: Morrison & Foerster LLP

20100221809 - Compositions and methods for the isolation of biologically active proteins: This invention is directed to compositions and methods for the isolation and further characterization of eukaryotic, mammalian, and/or human PC-PLC. In addition, the present invention discloses methods for the synthesis of an affinity chromatography resin for the isolation and purification of biologically active proteins, including eukaryotic PC-PLC.... Agent: Foley & Lardner LLP

20100221810 - Novel diglycosidase and gene encoding the same: i

20100221811 - Recombinant adenovirus useful for treating malignancy over-expressing proto-oncogene neu/erb b2: A recombinant adenovirus is applied for treating malignancy of over-expressing proto-oncogene neu/erbB2, wherein an expression cassette, which co-expresses the humanized monoclonal antibody variable region gene of anti proto-oncogene neu/erbB2 and the Mda-7/IL-24 gene, is inserted into E1 deletion region of the recombinant adenovirus. The recombinant adenovirus effectively treats the malignancy... Agent: David And Raymond Patent Firm

20100221812 - Production of genetically modified actinomycetes by recombination: r

20100221813 - Regulation of heterologous recombinant protein expression in methylotrophic and methanotrophic bacteria: Methylotrophic or methanotrophic bacteria such as Methylobacterium are transformed with a gene of interest, and expression of the gene is regulated by means of a cumate repressor protein and an operator sequence which is operatively linked to the gene of interest, and the addition of an external agent. Specifically, the... Agent: Cassan Maclean

20100221814 - Temperature control method and system: For heating or cooling a sample contained in a vessel portion through a heat transfer member held in contact with the vessel portion, there is used the vessel portion, which has a part formed of an elastic member, expands and contracts for injection and discharge of the sample, is closed... Agent: Young & Thompson

20100221815 - Substrates, devices, and methods for quantitative liquid crystal assays: The present invention relates to the field of molecular diagnostics, and in particular to diagnostics based on a liquid crystal assay format. In particular, the present invention provided improved substrates and methods of using liquid crystal assays for quantitating the amount of an analyte in a sample. The present invention... Agent: Casimir Jones, S.c.

20100221816 - Reaction kit: Disclosed is a reaction kit for preventing the entry of foreign matter into a reaction plate from the outside and the pollution of a surrounding environment. The reaction kit includes: a reaction plate (2) having, on the top surface side thereof, a reaction container (4) for carrying out the reaction... Agent: Cheng Law Group, PLLC

20100221817 - Whole-cell sensor: The invention relates to whole-cell sensors for monitoring bioavailable nitrogen, phosphorus and sulphur, individually or in at least one combination in a medium, and to the use thereof. The whole-cell sensors consist of genetically modified yeast cells which are immobilised in a xerogel matrix and contain at least one marker... Agent: Gudrun E. Huckett Draudt

20100221818 - Device for the extemporaneous preparation of active preparations: The invention relates to an autonomous portable device for the storage of at least two formulations and for the automatic extemporaneous preparation of an active solution from the two formulations, said device comprising: a first compartment for containment of a first formulation, a second compartment for containment of a second... Agent: Oliff & Berridge, PLC

20100221819 - Upflow hydrolysis reactor system for hydrolyzing cellulose: A process for the enzymatic hydrolysis of cellulose to produce a hydrolysis product from a pre-treated cellulosic feedstock is provided. The process comprises introducing an aqueous slurry of the pre-treated cellulosic feedstock at the bottom of a hydrolysis reactor. Axial dispersion in the reactor is limited by avoiding mixing and... Agent: Fitzpatrick Cella Harper & Scinto

20100221821 - Methods and compositions related to riboswitches that control alternative splicing and rna processing: Disclosed are methods and compositions related to riboswitches that control alternative splicing.... Agent: Patent Correspondence Arnall Golden Gregory LLP

20100221820 - Use of triplex structure dna in transferring nucleotide sequences: The invention concerns a recombinant vector characterised in that it comprises a polynucleotide comprising a central initiation cis-active region (cPPT) and a termination cis-active region (CTS), said regions being of retroviral or retroviral-like origin, said vector further comprising a predetermined nucleotide sequence (transgene or nucleotide sequence of interest) and retranscription... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100221822 - Humanized and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria: The present invention encompasses monoclonal and chimeric antibodies that bind to lipoteichoic acid of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and enhance protection from lethal infection in vivo. The mouse monoclonal antibody has been humanized and... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100221823 - Method for culturing mammalian cells to improve recombinant protein production: The present invention relates to methods for mammalian cell culture, wherein the methods make use of media containing polyamines, such as putrescine, spermidine and spermine.... Agent: Amgen Inc. Law Department

20100221824 - Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggybac: The present invention provides a method for transforming an insect genome that has a much enhanced transformation frequency. The vectors and plasmids employed in the method are further described as transposition vectors that include a minimal amount of nucleotide sequence homologous to a 5′ region and a 3′ region of... Agent: K&l Gates LLP

20100221825 - Avian cell lines useful for the production of substances of interest: The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the cells... Agent: Buchanan, Ingersoll & Rooney PC

20100221826 - Infectious cdna clone of the modified live virus vaccine strain of equine arteritis virus: An isolated polynucleotide molecule includes a DNA sequence encoding an infectious RNA molecule encoding a modified live viral strain of an Equine arteritis virus, wherein the DNA sequence is SEQ ID NO:1 or a degenerate variant thereof. Also provided are transformed or transfected host cells including that sequence, vectors including... Agent: King & Schickli, PLLC

20100221827 - Methods for reprogramming somatic cells: The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated... Agent: Morse, Barnes-brown & Pendleton, P.C. Attn:IPManager

20100221828 - Recombinant cell clones having increased stability and methods of making and using the same: Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention... Agent: Townsend And Townsend And Crew LLP

20100221829 - Media for culturing stem cells: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100221830 - Device and method for ambient storage of fresh/frozen tissue sections via desiccation: The present invention discloses a method for storing and preserving previously sectioned, snap-frozen, and desiccated biological tissue samples at ambient conditions. Also disclosed are devices and systems for ambient storage of biological tissue sections, and methods for forming said devices.... Agent: Hogan Lovells US LLP

20100221831 - Living body holding method, living body test method, living body growing method, living body holding sheet, and living body processing device: A method of arranging a large number of living bodies, such as cells, embryos, or organisms rapidly, individually, and one by one, a holding sheet for the method, and a device for processing the living bodies. The method of holding living bodies includes using a sheet in which multiple through-holes... Agent: Fitzpatrick Cella Harper & Scinto

20100221832 - Adsorbent for lymphocyte proliferation inhibitor and treating method: The invention relates to a porous material for body fluid treatment for promoting lymphocyte proliferation in lymphocyte culture which contains a high-molecular compound having an angle of contact with water within the range of 40° to 98°; and a porous material for body fluid treatment which comprises activated carbon. It... Agent: Connolly Bove Lodge & Hutz LLP

20100221833 - Process for differentiation of vascular endothelial progenitor cells from embryoid bodies derived from embryonic stem cells using hypoxic media condition: The present invention provides a process for differentiation of vascular endothelial progenitor cells from embryoid bodies derived from embryonic stem cells, the process comprising: (a) treating a culture medium comprising embryoid bodies derived from embryonic stem cells such that the concentration of oxygen dissolved in the culture medium is in... Agent: The Nath Law Group

20100221834 - Liquid crystalline substrates for culturing cells: The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.... Agent: Quarles & Brady LLP

20100221835 - Method for cartilage tissue regeneration via simulated microgravity culture using scaffolds: This invention relates to a method for cartilage tissue engineering using scaffolds in simulated microgravity culture. This invention enables engineering of homogeneous cartilage tissue using bone marrow cells in a more rapid manner in a simulated microgravity environment, while allowing control of the configuration of the resulting cartilage tissue.... Agent: Sughrue Mion, PLLC

20100221836 - Sol-gel materials for cellular modulation: A modified sol-gel material and method of making the same is provided herein. More particularly, sol-gels disclosed herein have been modified to have one or more bioactive peptides covalently bound to the surface of the sol-gel. In one embodiment the peptide presenting sol-gels are prepared as thin film coatings and... Agent: Barnes & Thornburg LLP

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