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Chemistry: molecular biology and microbiology August inventions list 08/10Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 08/26/2010 > patent applications in patent subcategories.
20100216109 - Method and apparatus for drug delivery to tissue or organ for transplant: It is intended to provide a method for delivering a drug such as a gene to a tissue or organ for transplant such as skin by use of a laser-induced stress wave (LISW) and thereby producing a high-performance tissue or organ for transplant with a high survival ability and to... Agent: Birch Stewart Kolasch & Birch
20100216110 - Method for ice-free cryopreservation of tissue: Method for preserving tissue including immersing the tissue in a solution having a cryoprotectant concentration of at least 75% by weight, a cooling step where the tissue is cooled to a temperature between the glass transition temperature of the solution having a cryoprotectant concentration of at least 75% by weight... Agent: Oliff & Berridge, PLC
20100216111 - Methods and apparatus for reducing protein content in sperm cell extenders: The inventive technology relates to methods and apparatus for reducing protein content in sperm cell extenders and may include one or more of the following features: techniques for reducing protein content in a sperm cell extender; techniques for reducing protein content in a cryoprotectant-containing B fraction of a sperm cell... Agent: Inguran LLC Attn: C. Ewell/r. Christensen/o. Espinosa
20100216112 - Crystal structures of both isoforms of human glutamic acid decarboxylase: A crystal comprising an isoform of an N-terminal truncation of GAD chosen from the group consisting of a monoclinic P2L space group with unit cell dimensions of a=84.05±2.3 Å, b=62.74±2.3 Å, c=101.35±2.3 Å and β=106.69 (GAD65) or an orthorhombic C222L space group with unit cell dimensions of a=78.25±2.3 Å, b=99.05±2.3... Agent: Ohlandt, Greeley, Ruggiero & Perle, LLP
20100216114 - Method and apparatus for determination of components in root crops: The invention relates to a process for the determination of components in root crops as well as a device for performing the process. Root crops of a plot are prepared in such a way that becomes possible, using near-infrared spectroscopy, to determine the content of substances with a high analytical... Agent: Patent Central LLC Stephan A. Pendorf
20100216113 - Methods: A method for selecting or designing a compound expected to modulate the activity of Leukotriene C4 synthase (LTC4S), the method comprising the step of using molecular modelling means to select or design a compound that is predicted to interact with the catalytic site or a substrate binding region of LTC4S,... Agent: Nixon & Vanderhye, PC
20100216115 - Methods and compositions for diagnostic use in cancer patients: Disclosed herein are methods and compositions useful for identifying therapies likely to confer optimal clinical benefit for patients with cancer.... Agent: Genentech, Inc.
20100216119 - Diagnostic methods for hiv infection: The invention relates to a method of aiding the diagnosis of a human immunodeficiency virus infection in a subject, said method comprising (i) providing a sample from the subject (ii) determining the level of ps20 in said sample (iii) comparing the level of ps20 of (ii) with the level of... Agent: Mcandrews Held & Malloy, Ltd
20100216118 - Method of detection/extraction, and related detection/extraction device: A method that uses an L-α-dipalmitoleoyl-phosphatidylcholine (DPPC) surfactant based device that reacts with a substance in a known manner, to detect a substance of interest or to extract a substance of interest from a material is provided. The principles of the present invention are particularly useful in detecting/measuring a substance... Agent: Lawrence R. Oremland, P.C.
20100216117 - Oligonucleotides, use, method of detection and kit for diagnosing the presence of the chikungunya virus e1 gene: The present invention concerns oligonucleotides intended to enable the amplification and the detection of a target sequence located in the E1 gene of the Chikungunya virus. These oligonucleotides are between 10 and 50 nucleotides in length and comprise at least one fragment of 10 consecutive nucleotides derived from the following... Agent: Oliff & Berridge, PLC
20100216120 - Rapid infectious virus assay: An assay to detect or quantify HIV infectious virus from clinically relevant cellular compartments, or reservoirs, in anti-retrovirally treated patients whose viral levels are low to undetectable is described. The method detects infectious virus in patients whose plasma viral loads are considered to be below the limit of current PCR... Agent: Kile Goekjian Reed & Mcmanus
20100216116 - Viral latency model: The invention relates generally to the field of virology. More particularly, the present invention relates to in vitro models for viral latency. In particular to latently infected cultures of primary and continuous cell lines, and to the use thereof in methods to identify anti-viral compounds. More in particular to identify... Agent: Castellano PLLC
20100216144 - Analysis of dna samples: The invention provides an improved method for obtaining information about DNA analysis of samples of uncertain origin by establishing the likelihood that they arose in certain manners compared with other possible manners. In this way all of the analysis information is taken into account and likelihood ratios are provided to... Agent: Merchant & Gould PC
20100216143 - Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength: An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or... Agent: Life Technologies Corporation C/o Intellevate
20100216145 - Assay for detecting circulating free nucleic acids: This invention is directed, inter alia, to methods and kits for rapid, easy and cost-effective methods of all free nucleic acid quantification in inter alia, biological fluid samples.... Agent: Townsend And Townsend And Crew, LLP
20100216141 - Compositions and methods to detect legionella pneumophila nucleic acid: Compositions are disclosed as nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes specific for Legionella pneumophila 16S or 23S rRNA sequences or DNA encoding 16S or 23S rRNA. Methods are disclosed for detecting the presence of L. pneumophila... Agent: Gen Probe Incorporated
20100216122 - Enzymatic nucleic acid synthesis: methods for direct detection of tagged monomers: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are... Agent: Life Technologies Corporation C/o Intellevate
20100216137 - Gene expression profiling for identification, monitoring and treatment of ovarian cancer: A method is provided in various embodiments for determining a profile data set for a subject with ovarian cancer or conditions related to ovarian cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100216131 - Gene expression profiling of esophageal carcinomas: The present invention generally regards gene expression profiling of esophageal cancers, including localized esophageal cancers. In particular, gene expression for a particular group of genes identifies individuals that are either going to be responsive to cancer therapy, for example chemotherapy and/or radiation, or that are not going to be responsive... Agent: Fulbright & Jaworski, LLP
20100216129 - Genetic loci associated with fusarium solani tolerance in soybean: The invention relates to methods and compositions for identifying soybean plants that are tolerant, have improved tolerance or are susceptible to Fusarium solani infection (the causative agent of sudden death syndrome or SDS). The methods use molecular genetic markers to identify, select and/or construct disease-tolerant plants or identify and counterselect... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.
20100216124 - Genetic markers of the risk of developing restenosis: Methods and kits for diagnosing the risk of developing restenosis after revascularization by implantation of stents based on the detection of single-nucleotide polymorphisms (SNPs).... Agent: Knobbe Martens Olson & Bear LLP
20100216154 - Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, variant proteins... Agent: Celera Corporation
20100216155 - Method and kit for identifying antibiotic-resistant microorganisms: The invention provides a rapid sample-processing method for preparing hybridization reaction mixtures substantially depleted of RNA, and a method of identifying the methicillin-resistance status and vancomycin-resistance status of an organism.... Agent: Gen Probe Incorporated
20100216138 - Method for dna breakpoint analysis: The present invention relates to a method for identifying a DNA breakpoint and agents for use therein. More particularly, the present invention provides a method for identifying a gene translocation breakpoint based on the application of a novel multiplex DNA amplification technique. The method of the present invention facilitates not... Agent: Knobbe Martens Olson & Bear LLP
20100216150 - Method for identifying a compound that modulates telomerase activity: The present invention embraces methods for identifying compounds that modulate the activity of telomerase. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the TRBD, “thumb,” “finger,” and/or “palm” domain; or FP-pocket, PT-pocket or Th-pocket of... Agent: Jane Massey Licata Licata & Tyrrell P.C.
20100216136 - Method for identifying a pork content in a food: Pork-specific PCR assay is performed for Halal authentication, by detecting porcine DNA in food products. DNA from raw meat samples is extracted. The extracted DNA is tested using primers that react by amplifying pork DNA but not beef and chicken DNA. The real-time PCR assay is sensitive with a low... Agent: Workman Nydegger 1000 Eagle Gate Tower
20100216152 - Method for the carry-over protection in dna amplification systems targeting methylation analysis achieved by a modified pre-treatment of nucleic acids: Particular aspects provide methods for specific amplification of template DNA in the presence of potentially contaminating PCR products from previous amplification experiments. Particular embodiments comprise, in a first step, contacting DNA with a bisulfite solution, which sulfonates unmethylated (but not methylated) cytosines, resulting in cytosine deamination and generation of sulfonated... Agent: Dla Piper LLP (us)
20100216121 - Method for the detection of predisposition to high altitude pulmonary edema: The present invention encompasses methods, compositions and kits for the detection of susceptibility to high altitude pulmonary edema in a human subject. The present invention further encompasses isolated polynucleotides for the detection of susceptibility to high altitude pulmonary edema in a human subject.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20100216123 - Method of detecting mutation and kit used in the same: A method of detecting a mutation is provided that uses Tm analysis and is excellent in detection sensitivity. A detection probe consisting of a polynucleotide complementary to a sequence to be detected containing a detection site that has been mutated and an inhibitory polynucleotide complementary to a sequence not to... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20100216132 - Methods and compositions for direct detection of dna damage: The present invention is a method for detecting the extent of DNA damage in a subject suspected of having DNA damage wherein the damage results in the formation of aldehyde moieties in DNA comprising, obtaining a DNA sample from the subject, combining the DNA sample with a fluorescent, chromogenic, pro-fluorescent... Agent: The Nath Law Group
20100216146 - Methods and kits for hybridizing multiple pna probe panels to nucleic acid samples: Described herein are methods and kits that employ multiple probe sets in combination with sequential steps of hybridization analysis for multiplex analysis and/or detection of nucleic acids having one or more distinguishable target sequences.... Agent: Life Technologies Corporation C/o Intellevate
20100216128 - Methods for analyzing agricultural and environmental samples: The present invention generally relates methods for analyzing agricultural and/or environmental samples using liquid bridges. In certain embodiments, the invention provides a method for analyzing an agricultural sample for a desired trait including obtaining a gene or gene product from an agricultural sample, in which the gene or gene product... Agent: Brown Rudnick LLP
20100216151 - Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities: The invention generally relates to methods for detecting fetal nucleic acids and methods for diagnosing fetal abnormalities. In certain embodiments, the invention provides methods for determining whether fetal nucleic acid is present in a maternal sample including obtaining a maternal sample suspected to include fetal nucleic acids, and performing a... Agent: Brown Rudnick LLP
20100216153 - Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities: The invention generally relates to methods for detecting fetal nucleic acids and methods for diagnosing fetal abnormalities. In certain embodiments, the invention provides methods for determining whether fetal nucleic acid is present in a maternal sample including obtaining a maternal sample suspected to include fetal nucleic acids, and performing a... Agent: Brown Rudnick LLP
20100216139 - Methods, compositions, and devices utilizing microrna to determine physiological conditions: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.... Agent: Fay Sharpe LLP
20100216126 - Microfluidic device: A microfluidic device comprising; i) an inlet; ii) a first layer comprising at least first and second current carrying structures, wherein the at least first and second current carrying structures each comprise a plurality of teeth, and wherein the teeth of the first and second current carrying structures are optionally... Agent: Senniger Powers LLP
20100216142 - Microrna biomarkers in lupus: The present invention provides methods of screening a subject for systemic lupus erythematosus (SLE), comprising detecting an increase in an amount of one or more markers associated with SLE in a biological sample from the subject, wherein the one or more markers is selected from the group consisting of miR-16-1,... Agent: Myers Bigel Sibley & Sajovec
20100216140 - Novel human dickkopf-related protein and nucleic acid molecules and uses therefor: Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule... Agent: Mcdermott Will & Emery
20100216148 - Novel tumor marker: The present invention concerns a gene product largely homologous to the epithelial growth factor receptor (EGFR). It further refers to mRNA coding for such epithelial growth factor receptor. The present invention provides such an epithelial growth factor receptor which is characterized in that either exons 12 to 14 or exons... Agent: Fanelli Strain & Haag PLLC
20100216125 - Nucleic acid analysis using sequence tokens: The present invention provides methods and compositions for tagging nucleic acid sequence fragments, e.g., a set of nucleic acid sequence fragments from a single genome, with one or more unique members of a collection of oligonucleotide tags, or sequence tokens, which, in turn, can be identified using a variety of... Agent: Bozicevic, Field & Francis LLP
20100216133 - Polynucleotides for use as tags and tag complements, manufacture and use thereof: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.... Agent: Goodwin Procter LLP Patent Administrator
20100216134 - Polynucleotides for use as tags and tag complements, manufacture and use thereof: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.... Agent: Goodwin Procter LLP Patent Administrator
20100216135 - Polynucleotides for use as tags and tag complements, manufacture and use thereof: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.... Agent: Goodwin Procter LLP Patent Administrator
20100216127 - Primer set for use in detection of yeast of genus saccharomyces: An object of the present invention is to provide a primer set, which can accurately, rapidly and simply identify yeast species of genus Saccharomyces. According to the present invention, there is provided a primer set for use in the detection of the yeast species of genus Saccharomyces, which comprises primers... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100216147 - Sequence-specific large volume sample preparation method and assay: Methods of selectively and rapidly identifying target nucleic acid molecules in large volumes of collection media where the target is present in a low concentration are disclosed. The methods can be used to identify, isolate, purify, or enrich a nucleic acid molecule containing a specific target sequence from a sample... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC
20100216130 - Single nucleotide polymorphisms associated with amyotrophic lateral sclerosis: Methods for determining the genetic predisposition of a human subject to developing ALS are provided herein. These methods include methods for determining the genetic predisposition to any form of ALS, as well as specific methods for determining the genetic predisposition to early onset, late onset, bulbar onset and limb onset... Agent: Jeffrey M. Jackson
20100216149 - Susceptibility genes for age-related maculopathy (arm) on chromosome 10q26: Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of ARM in an individual that comprises identification of allelic variations in PLEKHA1 and/or LOC387715. Related apparatus, such as an... Agent: Hirshman Law, LLC
20100216156 - Cancer markers: Provided are previously uncharacterized markers of cancers, for example colorectal cancers, and uses of these as diagnostic and prognostic markers of cancers, and in particular colorectal cancers. The markers are SEQ ID NO:1—hnRNP-K; SEQ ID NO:2—HMG-1; SEQ ID NO:3—proteasome subunit alpha type 1; SEQ ID NO:4—bifunctional purine biosynthesis protein; SEQ... Agent: Dann, Dorfman, Herrell & Skillman
20100216158 - Diagnostic test for head and facial pain: A diagnostic test for a head and facial pain disorder in a human patient includes providing test strip containing one or more antibodies corresponding one or more biological markers associated with the disorder or with multiple disorders. A saliva sample is collected from the human patient and applied to the... Agent: Husch Blackwell Sanders LLP
20100216157 - Immunoglobulin peptides against heated bovine blood: The present invention is related to immunoglobulin peptides that recognize a thermostable antigen from bovine blood. The invention also provides methods for determining the presence of bovine blood in a food sample or an animal feed sample.... Agent: Vedder Price, PC
20100216159 - Switchable affinity binders: Methods and kits for binding and releasing biological targets, comprising, a binder comprising an environmentally reactive molecular switch that can switch between a high affinity state, to bind the target, to a low affinity state, to release the target.... Agent: General Electric Company Global Research
20100216164 - Mammalian prickle gene: The present invention provides the mPrickle gene which encodes a protein present in mammalian PSD fractions. The mPrickle protein is localized in synapses, and binds to the scaffold protein PSD-95. Precipitation of endogenous mPrickle using an anti-mPrickle antibody results in the coprecipitation of NMDA receptors, and thus, mPrickle can be... Agent: Townsend And Townsend And Crew, LLP
20100216167 - Methods for relieving neuropathic pain by modulating alpha 1g t-type calcium channels and mice lacking alpha 1g t-type calcium channels: The present invention relates to a novel use of a transgenic mouse deficient in α1G T-type calcium channel as an animal model for the study of neuropathic diseases, more precisely, a novel use of a transgenic mouse having resistance against neuripathic pain as an animal model for the development of... Agent: Klarquist Sparkman, LLP
20100216166 - Target activated microtransfer: A device for performing target activated transfer that includes a mounting surface for mounting a tissue sample; and a light source positioned to substantially uniformly irradiate both stained and unstained regions of the tissue sample with light energy that activates the reagent to selectively adhere the stained regions to a... Agent: Klarquist Sparkman, LLP (ott-nih)
20100216165 - Use of soluble forms of the desmoglein i protein for the purposes of screening for anti-ageing active agents: The invention relates to the use of one or more complexed or noncomplexed, soluble peptide form(s) of Desmoglein I, as a marker for evaluating the effectiveness of active agents and/or of treatments, in particular anti-ageing active agents and/or treatments, with regard to an epidermis.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100216169 - Method for detecting and prognosing pre-cancerous cells using 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine: Presented is a method of prognosing a patient's response to a cancer therapy wherein prior to the therapy contacting a sample of cells from the patient's tissue or organ being treated for the cancer with a solution of TCPP to permit binding of the TCPP to components of the abnormal... Agent: Peacock Myers, P.C.
20100216168 - Methods for evaluating angiogenic potential in culture: The present invention provides a method of evaluating the angiogenic potential of a tumor, and for predicting the efficacy of anti-angiogenic therapies on an individualized basis. The method of the invention involves preparing an angiogenic signature for malignant cells in culture by assaying for the presence or level of one... Agent: Cooley LLP Attn: Patent Group
20100216170 - Methods for identifying immunobinders of cell-surface antigens: The invention provides methods for identifying immunobinders, such as scFv antibodies, capable of specifically binding to cell surface antigens, and compositions identified according to said methods.... Agent: Alcon
20100216171 - Reducing time to result for blood bank diagnostic testing: Methods for reducing time to result in blood bank diagnostic testing with an agitation device and a low ionic strength solution are disclosed. Specifically provided are methods for reducing incubation time for antigen-antibody reactions in an immunohematologic assay by subjecting the assay reactants to incubation with agitation and optionally additionally... Agent: Philip S. Johnson Johnson & Johnson
20100216172 - Flow-based enhancement of specificity for label-free biochemical assays: A label-free biochemical assay, in which label-free interrogation of a target-receptor layer is performed while the target-receptor layer is subjected to a relatively strong flow of an analyte-containing fluid. The volumetric flow rate for the assay is selected based on calibration data corresponding to the target substance, which advantageously results... Agent: Mendelsohn, Drucker, & Associates, P.C.
20100216161 - Method for identifying protease inhibitors: The invention describes a method for assaying HCV NS3 protease activity using an NS3•4A protease molecule. The invention also provides a method for screening and identifying modulators of NS3 protease.... Agent: Jonathan P. O''brien, Ph.d. Honigman Miller Schwartz And Cohn
20100216162 - Immunological method, test kit and device for the determination of the analyte content of a sample: The present invention relates to immunological methods for the determination of the analyte content in samples as well as to test kits and devices for performing the methods of the invention. In particular, the present invention relates to the analysis of samples of breeding animals, such as raw milk and... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100216163 - Lectin-based glycan assay: The invention relates to the use of deglycosylated detectors, especially secondary antibodies, for the determination of sugar structures of proteins, especially recombinant proteins. It further relates to the use of deglycosylated enzymes in the determination of sugar structures with the aid of an enzyme-substrate reaction; the invention further relates to... Agent: Ursula B. Day, Esq.
20100216173 - Citrullinated fibrin-filaggrin chimeric polypeptide capable of detecting the antibodies generated in rheumatoid arthritis: The present invention concerns a chimeric polypeptide, capable of detecting the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the α or β chain of the fibrin and (ii) a second derived from the filaggrin. In addition, the invention comprises an antigenic... Agent: Merchant & Gould PC
20100216174 - Method of evaluating thrombogenic microparticles: A method and a kit are disclosed for evaluating thrombogenic microparticles (MP). The principle is based on the evaluation of thrombin generation in platelet poor plasma (PPP) and in plasma made microparticle free (MPFP) by centrifugation or filtration. The difference in thrombin generation between PPP and MPFP correlates with number... Agent: Kf Ross PC
20100216175 - Condensate glucose analyzer: Systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments, electrochemical- or coulometnc-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose. Based on the detected glucose m EBC, the subject invention provides systems and methods for non-invasive, accurate assessment... Agent: Beusse Wolter Sanks Mora & Maire
20100216176 - Novel method for sequence determination using nmr: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.... Agent: Wolf Greenfield & Sacks, P.C.
20100216177 - Method and kit for universal verification of enzyme activity and protein digestion: A method of assessing enzyme function or protein stability is disclosed. A sample having a protein therein is contacted with an enzyme that is suspected of being capable of catalyzing digestion of the protein in order to form a mixture. First and second aliquots are removed from the mixture at... Agent: Cohen & Grigsby, P.C.
20100216178 - Method of stabilizing heme protein and storage solution therefor: A method of stabilizing a hem protein which is effective against the denaturation and degradation of a hem protein typified by hemoglobin and a storage solution therefor. A method of stabilizing a hem protein and a storage solution therefor characterized in that an iminocarboxylic acid or its salt is made... Agent: Oliff & Berridge, PLC
20100216182 - Cyanine-based probe\tag-peptide pair fluorescence protein imaging and fluorescence protein imaging methods: A molecular probe comprises two arsenic atoms and at least one cyanine based moiety. A method of producing a molecular probe includes providing a molecule having a first formula, treating the molecule with HgOAc, and subsequently transmetallizing with AsCl3. The As is liganded to ethanedithiol to produce a probe having... Agent: Wells St. John P.s.
20100216179 - Method for detecting cancer and reagents for use therein: A method for detecting cancer includes providing a biomedical sample, performing a first adsorption step, performing a first desorption step, and performing a first discrimination step. The first adsorbing step includes immersing the biomedical sample into a first detection reagent having a first adsorbent that adsorbs onto the biomedical sample.... Agent: Muncy, Geissler, Olds & Lowe, PLLC
20100216181 - Methods and compositions for the differentiation of stem cells: The present invention provides methods and compositions for the production of hematopoietic progenitor cells or endothelial progenitor cells from human pluripotent stem cells using a defined cell culture medium without the need to utilize feeder cells or serum. In some embodiments, differentiation is accomplished using hypoxic atmospheric conditions. The defined... Agent: Fulbright & Jaworski L.L.P.
20100216180 - Methods of using halogenated peptides as internal standards for liquid chromatography-mass spectrometry: Methods of using halogenated peptides as internal standards for liquid chromatography-mass spectrometry, and novel halogenated peptides useful for the same, are disclosed. In particular, methods of using halogenated peptides as internal standards in proteomic analyses, as well as methods of using halogenated peptides to conduct quality control assessments of and/or... Agent: Patent Correspondence Arnall Golden Gregory LLP
20100216183 - Microbial detection apparatus, microbial detection method, and sample container used therein: The sample container has a two-layer membrane filter comprising a first layer as an upper layer serving as a hydrophilic membrane filter and a hydrophobic membrane filter as an underlying second layer capable of filtering an aqueous solution without the use of a wetting agent and by means of a... Agent: Mattingly & Malur, P.C.
20100216185 - Engineered versions of polysialyltransferases with enhanced enzymatic properties: The invention relates to poly-sialyltransferse polypeptides with enhanced solubility and activity and methods of using the poly-sialyltransferases for production of poly-sialylated end products, e.g., oligosaccharides, glycoproteins and glycolipids.... Agent: Nada Jain, P.C.
20100216184 - Preparation of cell extract and its application for cell-free protein systhesis: Disclosed is a process for simply preparing cell extracts for use as a catalyst of cell-free protein synthesis by centrifugation, which improves cost effectiveness and productivity of cell-free protein synthesis. Specifically, a conventional process for preparing cell extracts comprises the complicated steps, i.e. cell culture, cell lysis, high-speed centrifugation, pre-incubation,... Agent: Ipla P.A.
20100216187 - Amino acid sequences that bind to a desired molecule in a conditional manner: The present invention relates to amino acid sequences that bind to serum proteins such as serum albumin; to compounds, proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions,... Agent: Wolf Greenfield & Sacks, P.C.
20100216186 - Novel sesquiterpene synthase gene and protein: The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene synthase (CVS) which codes for at least one CVS. The invention further provides nucleic acids comprising the nucleotide sequence coding for amino acid residues... Agent: Catalyst Law Group, Apc
20100216189 - Synthetic repetitive proteins, the production and use thereof: e
20100216188 - Use of chick beta actin gene intron-1: A method to use chick beta actin gene intron-1 or functional equivalent as a gene expression enhancer element or a gene expression “hot spot” sequence for constructing or reconstructing a mammalian expression vector for extremely high expression of recombinant proteins is disclosed. Composition of a set of extremely strong gene... Agent: Occhiuti Rohlicek & Tsao, LLP
20100216190 - Novel selection system: m
20100216191 - Method for manufacturing a modified peptide: The present invention relates to a method for manufacturing a modified polypeptide from a first polypeptide, said modified polypeptide exhibiting altered binding properties to a target molecule and/or having a different amino acid sequence compared to a first polypeptide comprising the steps of a) providing a first cell comprising a... Agent: Fulbright & Jaworski L.L.P.
20100216192 - Tailored multi-site combinatorial assembly: The present invention provides a novel method of producing a plurality of modified polynucleotides having different combinations of various mutations at multiple sites by a tailored multi-site combinatorial assembly, comprising adding at least two or at least three primers to a double stranded template polynucleotide in a single reaction mixture,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100216193 - Reaction chip, reaction method, temperature controlling unit for gene treating apparatus and gene treating apparatus: The reaction chip of the present invention has a plurality of recesses 6 constituting a part of a reaction container and a groove constituting a part of a channel formed on at least one of one face of a first base material (resin base material 2) and one face of... Agent: Squire, Sanders & Dempsey L.L.P.
20100216194 - Single-cell mrna quantification with real-time rt-pcr: The present invention is directed to a method for performing an RT-PCR for amplifying a target RNA comprising the steps of a) lysis of a cellular sample which is supposed to contain the target RNA with a lysis buffer comprising between 0.2 M and 1 M guanidine thiocyanate, b) diluting... Agent: Roche Diagnostics Operations Inc.
20100216195 - Enzymatic production of sucrose-6-ester, an intermediate for the manufacturing of halo sugars...: A novel process is described for production of 6-acyl-sucrose comprising enzymatic acylation of sucrose by an esterifying agent including an organic acid in presence of a lipase or an esterase in a solvent in which the enzyme used is stable. Chlorinated sucrose, the high intensity sweetener trichlorogalactosucrose can be prepared... Agent: The Nath Law Group
20100216196 - L-cysteine-producing bacterium and a method for producing l-cysteine: The present invention provides a bacterium belonging to the family Enterobacteriaceae, which is able to produce L-cysteine and has been modified to increase the activity of the protein encoded by the dsbA gene. This bacterium is cultured in a medium, and L-cysteine, L-cystine, a derivative or precursor thereof or a... Agent: Cermak Nakajima LLP Acs LLC
20100216197 - Microbial fermentation-based production of phospholipids containing long-chain polyunsaturated fatty acids as their constituents: The present invention relates to a method for producing a phospholipid containing a long-chain polyunsaturated fatty acid as a constituent (LCPUFA-PL), which comprises: (i) culturing a microorganism belonging to Mortierella sp. under conditions allowing intracellular accumulation of LCPUFA-PL in the microorganism; and (ii) obtaining LCPUFA-PL from the cultured product of... Agent: Drinker Biddle & Reath (dc)
20100216198 - Method for the synthesis of omega-unsaturated fatty acids: The invention relates to a method for the synthesis of short-chain ω-unsaturated fatty acids of general formula CH2═CH—(CH2)n—COOR in which n is an integer between 2 and 11 and R is H or an alkyl radical containing from 1 to 4 carbon atoms, from long-chain monounsaturated fatty acids or esters... Agent: Arkema Inc. Patent Department - 26th Floor
20100216199 - Production of long chain unbranched beta-poly(l-malic acid) by large scale physarum cultivation and high-grade purification of the same: The invention is a large-scale production and purification of beta-poly(L-malic acid), biodegradable natural polyester of L-malic acid of molecular weight 30,000 to 300,000 from plasmodia of the Physarum family, especially Physarum polycephalum. This will replace previous laborious and uncontrolled production by bioreactor methods of high productivity and quality, especially to... Agent: Eggehard Holler
20100216200 - Systems and methods for producing biofuels and related materials: Clostridium phytofermentans cells (American Type Culture Collection 700394T) and all other strains of the species can ferment materials such as biomass into useful products and coproducts, such as ethanol, hydrogen and organic acids. Compositions that include Clostridium phytofermentans are also disclosed.... Agent: Milstein Zhang & Wu LLC
20100216201 - Processes of producing fermentation products: The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or more carbonic anhydrases are present in the fermentation medium.... Agent: Novozymes North America, Inc.
20100216202 - Method and a system for the pretreatment of lignocellulosic material: The invention relates to a method and a system for the pretreatment of lignocellulosic material by thermal hydrolysis, in particular with a view to producing bioethenol, wherein the material is first admixed with water and is then passed to a reactor, in which the soaked material is subjected to a... Agent: William J. Sapone Coleman Sudol Sapone P.C.
20100216203 - Algae bioreactor using submerged enclosures with semi-permeable membranes: Methods for producing hydrocarbons, including oil, by processing algae and/or other micro-organisms in an aquatic environment. Flexible bags (e.g., plastic) with CO2/O2 exchange membranes, suspended at a controllable depth in a first liquid (e.g., seawater), receive a second liquid (e.g., liquid effluent from a “dead zone”) containing seeds for algae... Agent: Nasa Ames Research Center Attn: Patent Counsel
20100216204 - Nucleic acid sequences to proteins involved in tocopherol synthesis: Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.... Agent: Sonnenschein Nath & Rosenthal LLP
20100216205 - Reagents and methods for cyanobacterial production of bioplastics and biomaterials: The present invention provides reagents and methods for biomaterial production from cyanobacteria.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20100216206 - Method for preparing an acellular organic tissue for revitalisation and device for implementing said method: The invention concerns a method for preparing an acellular organic tissue for revitalisation by means of the reimplantation of living cells, said method involving the following stages: preparing the acellular tissue on an essentially flat surface, creating a plurality of holes on the surface of the tissue, distributed all over... Agent: Ip Strategies
20100216207 - Apparatus and method for growing algae by ionizing radiation: An apparatus is disclosed for growing algae by ionizing radiation. The apparatus includes a container for containing medium for the growth of algae, a filter disposed in the container, a 3-dimensional rack disposed in the container, an adherent element wound on the 3-dimension rack so that spores of the algae... Agent: Jackson Intellectual Property Group PLLC
20100216208 - Multiple laminar flow-based particle and cellular separation with laser steering: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a... Agent: Akerman Senterfitt
20100216209 - Immobilized lipase and method for producing the same: Disclosed is an immobilized lipase which is improved in transesterification activity when compared with conventional immobilized lipases. Specifically disclosed is an immobilized lipase remarkably improved in transesterification activity, which is obtained by immobilizing an oil-in-water emulsion containing an enzyme having a lipase activity, a polymer emulsifier and a fat/oil to... Agent: Wenderoth, Lind & Ponack, L.L.P.
20100216210 - Methods and compositions for repair of cartilage using an in vivo bioreactor: Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of... Agent: Fulbright & Jaworski, LLP
20100216211 - Fibrous mats containing chitosan nanofibers: The invention relate to fibrous mats comprising chitosan nanofibers and, optionally, at least one filler material, at least one additive, or both. The invention also relates to methods of making same, and devices that include a fibrous mat comprising chitosan nanofibers.... Agent: Woodcock Washburn LLP
20100216212 - Anti-obesity agent and anti-obesity food: An anti-obesity agent containing, as an active ingredient, a microorganism which belongs to the species Lactobacillus reuteri and is capable of producing lipases having the amino acid sequences respectively depicted in SEQ ID NO: 1, 3 or 5 or amino acid sequences having deletion, substitution or addition of one or... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100216213 - Polypeptides having glucoamylase activity and polynucleotides encoding same: The present invention relates to polypeptides having glucoamylase activity and isolated polynucleotides encoding said polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. The invention also relates to the composition comprising a glucoamylase... Agent: Novozymes North America, Inc.
20100216214 - Nitrilases, nucleic acids encoding them and methods for making and using them: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.... Agent: Verenium Corporation Intellectual Property Department
20100216215 - Method and device for the concentration of multiple microorganisms and toxins from large liquid toxins: A method for the simultaneous concentration of multiple toxins from large volumes of water. The method includes the steps of providing a disposable separation centrifuge bowl, the centrifuge bowl including a positively charged material at it's inner core. A large water sample contaminated with toxins from a group consisting of... Agent: David S. Resnick
20100216216 - Microorganism of corynebacterium genus having resistance to kanamycin and enhanced l-lysine productivity and method of producing l-lysine using the same: Provided are a microorganism of Corynebacterium genus capable of producing L-lysine and resistant to kanamycin, and a method of producing L-lysine using the same.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100216217 - Steady state anaerobic denitrifying consortium for application in in-situ bioremediation of hydrocarbon-contaminated sites and enhanced oil recovery: Enriched steady state microbial consortiums for microbial enhanced oil recovery and in situ bioremediation of hydrocarbon-contaminated sites, under anaerobic denitrifying conditions, are disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20100216218 - Apparatus for carbon dioxide-capture system and use of the same: An apparatus for carbon dioxide-capture system has a cultivating vessel and at least one basking mechanism. The cultivating vessel has a reservoir for accommodating alga culture. The basking mechanism is mounted in the reservoir of the cultivating vessel and has multiple trays and a circulating mechanism. The trays are imbricately... Agent: Andrews Kurth LLP
20100216219 - Method of in situ bioremediation of hydrocarbon-contaminated sites using an enriched anaerobic steady state microbial consortium: A method for in situ bioremediation of hydrocarbon-contaminated sites using an enriched steady state microbial consortium capable of modifying crude oil components under anaerobic denitrifying conditions is disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20100216220 - Devices and methods for the purification, isolation, desalting or buffer/solvent exchange of substances: A spin column device, which contains a rigid porous filter that retains its shape during centrifugation, chromatography methods using the device to isolate a desired substance, e.g., a biological molecule, from other substances in a mixture, and kits containing the device with one or more reagents for use in the... Agent: Sheldon Mak Rose & Anderson PC
20100216221 - Device with which a histological section generated on a blade of a microtome can be applied to a slide: A device for applying a histological section to a slide is described. The histological section is generated by a cutting action performed by a blade of a microtome. The device comprises a positioning device having a component that is rotatably mounted to a bearing and has a receptacle for receiving... Agent: Alexander R Schlee SchleeIPInternational P.C.
20100216222 - Tissue infiltration device: The present invention relates to a tissue infiltration device (1) for samples (34) contained in cassettes (5). The tissue infiltration device (1) comprises at least two liquid containers (7, 11a-11d, 13, 15) and a transport apparatus (6). A liquid (12, 14, 16) having a property that can be predetermined can... Agent: Hodgson Russ LLP The Guaranty Building
20100216223 - Reagent preparing device, specimen measuring device and reagent preparing method: A reagent preparing device for preparing a reagent to be supplied to a measurement device for measuring a specimen, comprising: a first liquid storage unit for storing a first liquid; a reagent storage unit for storing a prepared reagent, including the first liquid and a second liquid different from the... Agent: Brinks Hofer Gilson & Lione
20100216224 - Reagent preparing device, specimen processing system and reagent preparing method: A reagent preparing device capable of supplying a mixed solution, including a first liquid and a second liquid, to a measurement section for measuring a specimen using the mixed solution as a reagent, the reagent preparing device comprising: a first mixed solution container for accommodating the mixed solution; a second... Agent: Brinks Hofer Gilson & Lione
20100216225 - Portable microorganism detection unit: The present invention is a portable device for detecting microorganisms in a food sample. The device includes a DNA extraction tube, a chip, and a portable control unit. The DNA extraction tube extracts DNA from the sample in an aqueous solution. The extraction tube includes successive chambers that are configured... Agent: Husch Blackwell Sanders LLP
20100216226 - Device, system, and method for controllably reducing inflammatory mediators in a subject: Devices, systems, and methods are provided for controlling an inflammatory response in a subject. Devices, systems, and methods are provided that alter the functional structure of one or more inflammatory mediators in the peripheral blood of the subject. The device or system is useful in a method for treating an... Agent: The Invention Science Fund Clarence T. Tegreene
20100216227 - Rotatable sample disk and method of loading a sample disk: A rotatable sample disk configured for samples of biological material. The sample disk may include a fill chamber for storing a first biological material, a plurality of first sample chambers positioned in the sample disk farther from the rotational axis of the sample disk than the fill chamber, a plurality... Agent: Life Technologies Corporation C/o Intellevate
20100216228 - Microarray with microchannels: A microarray formed in a planar surface of a moldable slab, the microarray including a plurality of microwell sets comprising a plurality of microwells formed in the planar surface of the moldable slab, each microwell being sized to contain at least a single cell, and a plurality of microchannels formed... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100216229 - Cell culture system with manifold: A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an... Agent: Corning Incorporated
20100216230 - Systems for increased cooling and thawing rates of protein solutions and cells for optimized cryopreservation and recovery: In systems and methods for freezing and subsequently thawing liquid samples containing biological components, a sample is fractioned into a very large number of small drops (10) having surface area to volume ratios of 1000 m-1 or greater. The drops are projected at a liquid cryogen (40) or at the... Agent: Jones, Tullar & Cooper, P.C.
20100216231 - Vectors for directional cloning: The invention provides vectors and methods for directional cloning.... Agent: Michael Best & Friedrich LLP
20100216233 - Attenuated invasive e.coli strains and applications thereof as intracellular vector for therapeutic molecule: The invention relates to a vectorial system capable of delivering a nucleic acid of interest into eukaryotic target cells, said vectorial system including a recombinant non-pathogenic and non-replicative Escherichia coli bacterium (E. coli) having integrated into its chromosome, in a targeted manner and without any antibiotic marker, one or more... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20100216232 - Mammal dedicated cell line: A mammal dedicated cell line is provided, which is a HepG2 hepatocellular carcinoma cell line (HepG2/NF-kB/Luc/sr39tk)1_18 obtained by co-transformation with NF-kB/Luc and NF-kB/sr39tk. Firstly, a successfully transformed pNF-kB/Luc HepG2 cell is obtained. Then, a dedicated cell line sensitive to TPA and MTX is generated by experimental screening Next, a plasmid... Agent: Wpat, PC Intellectual Property Attorneys
20100216234 - Anti-il-12 antibody based vectors, host cells, and methods of production and uses: Antibody expression vectors and plasmids can incorporate various antibody gene portions for transcription of the antibody DNA and expression of the antibody in an appropriate host cell. The expression vectors and plasmids have restriction enzyme sites that facilitate ligation of antibody-encoding DNA into the vectors. The vectors incorporate enhancer and... Agent: Philip S. Johnson Johnson & Johnson
20100216235 - Dipeptidyl peptidases: Peptides including HisGlyTrpSerTyrGlyGlyPheLeu; LeuAspGluAsnValHisPhePhe; GluArgHisSerIleArg and PheValIleGlnGluGluPhe which show peptidase ability and have substrate specificity for at least one of the compounds H-Ala-Pro-pNA, H-Gly-Pro-pNA and H-Arg-Pro-pNA are disclosed. Nucleic acids, vectors, antibodies and hybridoma cells are also claimed with reference to the above sequences and their abilities.... Agent: Husch Blackwell Sanders, LLP Husch Blackwell Sanders LLP Welsh & Katz
20100216236 - Nuclear reprogramming factor and induced pluripotent stem cells: The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including... Agent: Greenblum & Bernstein, P.L.C
20100216237 - Optimized and defined method for isolation and preservation of precursor cells from human umbilical cord: The present invention refers to an optimized and defined method for isolation and preservation of precursor cells from human umbilical cord. Besides being reproducible and 100% reliable, in terms of the number of samples processed, the method results in a high and defined number of precursor cells, being the majority... Agent: Kenealy Vaidya LLP
20100216238 - Compositions and methods for modulation of smn2 splicing: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.... Agent: Jones Day For Isis Pharmaceuticals, Inc.
20100216241 - Forming cell structure with transient linker in cage: In a method of forming a cellular structure, cells and a transient linker are supplied to a volume partially enclosed by a cage. The linker facilitates initial attachment of adjacent cells to form a cell aggregate. The cage defines distributed openings that are sized to retain the cell aggregate. A... Agent: Klarquist Sparkman, LLP
20100216239 - Isolated nature-identical collagen: The present invention concerns isolated collagen, the method for its production, and isolation of the collagen from collagen-containing tissues, as well as the use of the isolated collagen in a biomatrix as an in vitro test system, tissue replacement or organ replacement.... Agent: Dickstein Shapiro LLP
20100216240 - Non-invasive automated cell proliferation apparatus: A cell proliferation apparatus for the automated culturing of cells, the proliferation apparatus including a bioreactor having contained therein a stimulus-responsive three dimensional (3D) cell scaffold, the stimulus-responsive three-dimensional (3D) cell scaffold being operable reversibly to change its surface properties between hydrophilic and hydrophobic states. The cell scaffold comprises a... Agent: Barnes & Thornburg LLP
20100216242 - Cell culture support and production method and uses thereof: The present teachings provide a practical cell culture support by which a cell culture with a high degree of freedom can be realized. More specifically, the cell culture support includes a polymer layer exhibiting thermoresponsiveness and a cell culture region obtained by plasma-treating a surface layer portion thereof with a... Agent: Oliff & Berridge, PLC
20100216243 - Metal alginate hydrogel and articles thereof: The present invention provides novel metal alginates prepared from non-cross-linked alginate monomers such as sodium alginate and an aqueous solution of a group 4, 5, or 6 metal oxyhalide. The novel group 4, 5, and 6 metal alginates are useful in the preparation of cell culture supports, exhibit useful X-ray... Agent: General Electric Company Global Research
20100216244 - Microfluidic chip and method using the same: Disclosed is a microfluidic chip and method using the same. The microfluidic chip comprises a substrate having a surface, and at least a tissue culture area formed on the surface of the substrate. The tissue culture area has a microfluidic channel formed by a plurality of connected geometrical structures (nozzle-type... Agent: Hogan Lovells US LLP
20100216245 - Frozen cell immobilized product, primary hepatocyte culture tool, and method for producing primary hepatocyte culture tool: The present invention provides a frozen cell immobilized product which is obtained by applying a technique for freezing cultured cells to a technique for forming primary hepatocyte spheroids through co-culturing, and which can improve performance in an examination or a test using the technique for forming primary hepatocyte spheroids; a... Agent: Young & Thompson08/19/2010 > patent applications in patent subcategories.
20100209902 - Use of a globin, a globin protomer or an extracellular hemoglobin for the preservation of organs, tissues, organ and tissue cells and cell cultures: The invention relates to the use of at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin for the preservation of organs, tissues, organ and tissue cells and cell cultures.... Agent: Mcandrews Held & Malloy, Ltd
20100209904 - Antibodies for oncogenic strains of hpv and methods of their use: The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The... Agent: Wilson, Sonsini, Goodrich & Rosati
20100209903 - Method for measuring resistance of a patient hiv-2 to protease inhibitors: A search method in a biological sample containing an HIV-2 viral strain for possible resistance of said strain to treatment by an anti-protease agent, and nucleotide probes for the implementation thereof. According to methods known per se, the presence of at least one mutation at certain, specified, particular positions of... Agent: Oliff & Berridge, PLC
20100209905 - Protein d - an igd-binding protein of haemophilus influenzae: A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20100209916 - Apparatus, system, and method using immiscible-fluid-discrete-volumes: Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic... Agent: Life Technologies Corporation C/o Intellevate
20100209909 - Assays based on detection of photobleaching reaction products from dye catalytic complex: The present invention relates to the methods for assaying an analyte comprising a nucleic acid analog binding substrate in a sample, comprising reacting a catalytic complex comprising a nucleic acid analog, a nucleic acid analog specific binding substrate and a light reactive dye with a light stimulus, and detecting the... Agent: Brinks Hofer Gilson & Lione
20100209931 - Compositions for identifying novel compositions for the treatment of disease and methods of using same: Disclosed herein are compositions useful for identification of potential therapeutic agents for the treatment of a disorder associated with RAS deregulation or dysregulation. The compositions may be a yeast cell having one or more mutations in an IRA gene or an ERG gene. Also disclosed are methods of using these... Agent: Frost Brown Todd, LLC
20100209921 - Digital amplification: The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules... Agent: Banner & Witcoff, Ltd.
20100209915 - Gene expression profiling for identification, monitoring, and treatment of ocular disease: A method is provided in various embodiments for determining a profile data set for a subject with ocular disease or conditions related to ocular disease based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100209920 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon... Agent: Genomic Health, Inc. (bozicevic, Field & Francis) C/o Kathleen Determann
20100209928 - Grading, staging and prognosing cancer using osteopontin-c: The present disclosure provides methods and kits that can be used to determine the grade or stage of a breast or other cancer, such as a ductal carcinoma in situ (DCIS). By determining the grade, stage, or aggressiveness of a cancer, appropriate therapeutic regiments can be selected and administered to... Agent: Ventana Medical Systems, Inc. Attention: Legal Department
20100209925 - Hybridization method and apparatus: A target nucleic acid contained in a sample solution is hybridized with a probe nucleic acid capable of binding specifically to the target nucleic acid and immobilized on a substrate. The process includes hybridizing the target nucleic acid with the probe nucleic acid, collecting the sample solution that has undergone... Agent: Fitzpatrick Cella Harper & Scinto
20100209907 - Isolated mammalian monocyte cell genes; related reagents: Nucleic acids encoding various monocyte cell proteins from a primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.... Agent: Merck C/o Dnax
20100209912 - Method for the treatment of a sample containing biomolecules: The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid and/or one species of protein, whereby the method comprises the following steps: A) providing a sample which contains at least... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC
20100209922 - Method of determining the nucleotide sequence of oligonucleotides and dna molecules: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown... Agent: Brown Rudnick LLP
20100209934 - Method of identifying agents which modulate the activity of calcium-activated chloride channel: The present invention provides a method of identifying an agent which modulates an activity of a protein, wherein the protein is represented by the amino acid sequence of SEQ ID NO: 1 or has at least 90% amino acid sequence identity to SEQ ID NO: 1 and transports chloride ions... Agent: Sughrue Mion, PLLC
20100209906 - Methods and compositions for detecting colon cancers: This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.... Agent: Ropes & Gray LLP
20100209933 - Methods and compositions for detection and enrichment of target small rnas: Methods and compositions are provided for detecting small target RNAs where the target RNA may be single-stranded or double-stranded and may be contained in a mixture of RNAs of different types and sizes. The methods and compositions utilize a p19 fusion protein that is capable of binding double-stranded RNA in... Agent: Harriet M. Strimpel, D. Phil.
20100209910 - Methods and systems for identifying polynucleotide sequences with translational self-cleavage activity: Provided herein are methods and systems for identifying 2A-like sequences with translational self-cleavage activity in an insect expression system.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP
20100209926 - Methods for detecting neutralizing antibodies for bone morphogenetic proteins: The present invention relates to methods of detecting neutralizing antibodies for bone morphogenetic proteins (BMP). More particularly, it relates to a highly specific, robust, rapid and accurate cell-based assay for detecting the presence of anti-BMP neutralizing antibodies.... Agent: Ropes & Gray LLP
20100209913 - Methods for the cytological analysis of cervical cells: The invention provides for a diagnostic test to monitor cancer-specific genetic abnormalities to diagnose cervical cell disorders and predict which patients might progress to cancer. Genetic abnormalities are detected by identification in chromosomal copy number of chromosome 3 and chromosome 5 using FISH analysis of probes targeted to 3 q... Agent: Saul Ewing LLP (baltimore) Attn: Patent Docket Clerk
20100209914 - Methods, systems, and kits for evaluating multiple sclerosis: The present invention provides a method for evaluating multiple sclerosis (MS), or excluding MS as a diagnosis for a patient The method comprises determining a gene expression profile for a sample from such a patient. The gene expression profile, which contains gene expression values for a plurality of genes that... Agent: Cooley LLP Attn: Patent Group
20100209932 - Microrna and messenger rna detection on arrays: The present teachings provide methods for reverse transcribing, and detecting, a plurality of small nucleic acids such as micro RNAs, from the same reaction mixture as a plurality of messenger RNAs. High levels of multiplexing are provided by the use of a plurality of zip-coded stem-loop reverse transcription primers, along... Agent: Life Technologies Corporation C/o Intellevate
20100209911 - Microsatellite maker combination and method for identifying lanyu pig breed: The present invention provides a microsatellite marker combination for identifying Lanyu pig breed, and the identification method thereof. The identification method comprises the following steps: (a) providing a genomic DNA sample obtained from a pig; (b) identifying the polymorphism of microsatellite markers of said genomic DNA sample; and (c) analyzing... Agent: Bacon & Thomas, PLLC
20100209929 - Multiple mechanisms for modulation of jak/stat activity: An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins... Agent: Wilson, Sonsini, Goodrich & Rosati / Nodality, Inc
20100209924 - Nuclear localization of src-family tyrosine kinases is required for growth factor-induced euchromatinization: A method for quantitatively evaluating chromatin structural changes using pixel imaging of the nucleus is provided. Pixel imaging of the nucleus can include capturing one or more images of a nucleus of one or more nucleic acid stain treated cells. The stain intensity can be measured by quantitating the intensity.... Agent: Kilyk & Bowersox, P.l.l.c.
20100209935 - Nucleic acid ligand diagnostic biochip: A nucleic acid ligand “biochip” is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily... Agent: Swanson & Bratschun, L.L.C.
20100209917 - Polymorphic length of foxe1 alanine stretch and genetic susceptibility to thyroid dysgenesis: The present invention concerns a method for diagnosis an increased likelihood of developing a thyroid dysgenesis (TD) for an individual, wherein said method comprises determining the length of the polyalanine repeat of the protein encoded by at least one allele of the FOXE1 (Forkhead box E1) gene in a tissue... Agent: Birch Stewart Kolasch & Birch
20100209919 - Polynucleotide markers: The invention relates to polynucleotides that are closely linked to the bolting gene or B gene within the sugar beet genome and can be used for the development of molecular markers. The invention further relates to molecular markers and kits comprising said markers that can be used for mapping, identification... Agent: Syngenta Biotechnology, Inc. Patent Department
20100209930 - Preservation of cell-free nucleic acids: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of... Agent: Dobrusin & Thennisch PC
20100209927 - Processing device tablet: A microfluidic processing device includes a tablet comprising a reagent, where the tablet is configured to fit within at least one chamber of the processing device. In addition, in some embodiments, at least two tablets are disposed within a single process chamber of the processing device. Further, in some embodiments,... Agent: 3m Innovative Properties Company
20100209908 - System and method for nucleotide sequence profiling for sample identification: The invention includes a method of sample profiling for identification. The method includes the steps of performing less than four nucleotide-specific chemical cleavage reactions to obtain nucleotide sequence fragments, performing size separation on the fragments, detecting the fragments' separation, generating a profile based on the detection, and comparing the profile... Agent: Intellectual Property Group Fredrikson & Byron, P.A.
20100209918 - System substitute pcr: The present invention relates to the substitute PCR of molecular diagnosis through the direct test-gene PCR substituted with indicator-DNA amplification. The present art has developed a new concept that the test-DNA is translated into the indicator-DNA following the indicator-DNA indirect PCR. In one aspect of this substitute PCR involves the... Agent: Buchanan, Ingersoll & Rooney PC
20100209939 - Bnp(1-32) epitope and antibodies directed against said epitope: The present invention relates to a polypeptide carrying a human BNP(I-32) epitope according to Formula (I): a1-R1-X1-FGRKMDR-X2-R2-a2 as well as ligands specific of the FGRKMDR epitope.... Agent: Jacobson Holman PLLC
20100209940 - Fibrosis biomarker assay: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope, and wherein... Agent: Edwards Angell Palmer & Dodge LLP
20100209937 - Fluorescence microscope in a microwave cavity: The present invention relates to an optical imaging system communicatively connected to a microwave energy producing source wherein the combination provides for increases in chemical reaction times and the ability to monitor the reactions in real time with sufficient resolution to view the location of intracellular components labeled with luminescent... Agent: Moore & Van Allen PLLC
20100209938 - Methods and systems for detection of stoichiometry by forster resonance energy transfer: Methods to detect stoichiometries of protein complexes and/or interactions between proteins based on detection and quantification of FRET and related systems and compositions.... Agent: Steinfl & Bruno
20100209936 - Novel recombinant 15-kda polypeptide and use of same in detecting human infection with bartonella henselae: Disclosed are the cloning and expression of a novel antigen of Bartonella henselae. The recombinant polypeptide is found to be highly immunogenic and is useful as a diagnostic test antigen. The polypeptide of the present invention provides the basis of a diagnostic assay that is sensitive, rapid and accurate diagnosis... Agent: Medical Diagnostic Laboratories, LLC
20100209946 - Uses of water-dispersible silica nanoparticles for attaching biomolecules: Uses of silica nanoparticles functionalized with water-dispersible groups, shielding groups, and biomolecule-binding groups.... Agent: 3m Innovative Properties Company
20100209943 - Measurement of protease activity in post-mortem meat samples: The present methods and systems relate to the placement on meat surfaces of a dye-linked protease substrate bonded in a defined location to a solid, porous support. Proteases in the meat hydrolyze the substrate, which then releases the dye, which diffuses away so that the extent of diffusion can be... Agent: Lathrop & Gage LLP
20100209941 - Method, device and kit for determining conditions related to a dysfunction of the renal proximal tubule: A method, device and kit are disclosed for determining a condition related to dysfunction of the Renal Proximal Tubule (RPT) by detecting the presence of type III Carbonic Anhydrase, CAIII, in a urine sample of a subject. The method is used for diagnosis and to monitor the progress of a... Agent: Knobbe Martens Olson & Bear LLP
20100209942 - New biomarker for monitoring development of diseases and assessing the efficacy of therapies: The invention concerns a method for monitoring the development of a disease in a patient, or for assessing the efficacy of a cytokine therapy or a statin therapy in a patient, in which methods CD73 in a tissue fluid drawn from said patient is used as a biomarker. The invention... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100209944 - Adamts-7 as a biomarker for cancers of epithelial origin: ADAMTS-7 expression and activity are up regulated in patients that have cancers of epithelial origin. Accordingly, the present invention is directed to methods diagnosis of cancers of epithelial origin (e.g. breast cancer, prostate cancer, bladder cancer, brain cancer and hepatic cancer). In particular, the presence of ADAMTS-7 in a biological... Agent: Wolf Greenfield & Sacks, P.C.
20100209945 - Method for preparing antibody monolayers which have controlled orientation using peptide hybrid: The present invention relates to a method for preparing an protein monolayer using a peptide hybrid for protein immobilization, more precisely a peptide hybrid for protein immobilization which has improved solubility by introducing a PEG linker and a proper reaction group to the oligopeptide having specific affinity to selected types... Agent: Lucas & Mercanti, LLP
20100209948 - Biomarkers associated with nephropathy: Use of urine biomarkers for diagnosing nephropathy, monitoring nephropathy progress, and assessing efficacy of a nephropathy treatment. These urine biomarkers include leukocyte-associated Ig-like receptor-2, alpha-1 acid glycoprotein, their fragments, and combinations thereof.... Agent: Occhiuti Rohlicek & Tsao, LLP
20100209947 - Free human serum ige immunoenzymetric assay and methods of use: The present invention relates to the development of novel of free blood fluid IgE Immunoenzymetric assay that is specifically designed to evaluate the blood fluid of patients on therapeutic agents designed to reduce free serum IgE levels, such as Omalizumab. The assay displays the robustness required for clinical analysis of... Agent: Edwards Angell Palmer & Dodge LLP
20100209949 - Luminescence measurement method and luminescence measurement system: Disclosed is a luminescence measuring method which can produce a luminous intensity depending on the amount of a substance to be measured even when the substance occurs in a biological sample in an amount equal to or more than a given amount, and which can achieve quantitative measurement. The method... Agent: Scully Scott Murphy & Presser, PC
20100209950 - Granulocyte-based methods for detecting and monitoring immune system disorders: Methods are provided for determining a subject's susceptibility to an allergic reaction upon exposure to an offending allergen. Methods are also provided for determining and monitoring a subject's responsiveness to ongoing allergy treatment... Agent: Andrea Blecken
20100209951 - Methods for assaying alpha-l-iduronidase enzymatic activity: Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20100209952 - Methods for diagnosis and monitoring of neurological disease by detection of an excephalotoxin: Encephalotoxin produced by activated mononuclear phagocytes is present in individuals having neurological disease including neurodegenerative and neuro-inflammatory diseases, such as Alzheimer's disease (AD), HIV-1-associated dementia (HAD), Creutzfeldt-Jakob disease, Mild Cognitive Impairment, prion disease, minor cognitive/motor dysfunction, acute stroke, acute trauma, or neuro-AIDS. Biochemical detection of encephalotoxin according to the methods... Agent: Woodcock Washburn LLP
20100209953 - Method of determining carbonic anhydrase i activity: A method for determining hydrolase activity of carbonic anhydrase I (CAI) in a sample which employs, combination of a substrate and an inhibitor. The substrate is a substrate having higher reactivity with CAI than with CAII selected from 2-hydroxy-5-nitro-α-toluenesulfonic acid sultone, a o-nitrophenyl ester, a p-nitropheylthio ester, and a β-naphthyl... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100209954 - Method of identification and quantification of proteins, isoforms of the angiotensin i converting enzyme, molecular genetic marker based on said proteins, use of mentioned marker, analytical method for diagnosis, risk stratification, therapeutical decisio: A method of detecting a predisposition for the development of a kidney lesion in an individual including detecting a presence of at least three angiotensin converting enzyme isoforms in an aliquot of fresh or concentrated biological fluids, cells or tissues obtained from the individual; and quantifying the presence of the... Agent: Ohlandt, Greeley, Ruggiero & Perle, LLP
20100209956 - Methods and compositions for modulating hepatocyte growth factor activation: The invention provides methods and compositions for modulating hepsin activity and the HGF/c-met signaling pathway, in particular by regulating pro-HGF activation by hepsin.... Agent: Genentech, Inc.
20100209955 - Methods for the delivery of toxins or enzymatically active portions thereof: The present invention relates to methods, systems, and kits for intoxicating cells, neuronal and non-neuronal cells, with a toxin or fragment thereof. This is done by subjecting toxin substrate and a lipid or polymeric carrier (e.g., DNA uptake facilitating agent) to one or more cells for use in cell based... Agent: Antoinette G. Giugliano, P.C. Dba Agg Intellectual Property Law
20100209957 - Biosample storage devices and methods of use thereof: The present invention provides sample collection, shipping, and storage devices and methods of using the same. These devices and methods are useful, for example, for collecting, shipping, and storing biological samples, such as blood, serum, buccal samples, tissue homogenates, or cell lysates in a dry state. The devices and methods... Agent: Cooley LLP Attn: Patent Group
20100209964 - Method and apparatus for analyzing sample: A method for analyzing a sample includes the step of irradiating a reaction portion of a sample BL and a reagent 40 in a reaction cell 34A of an analysis tool with light to obtain data D0 indicating optical characteristics of this portion. The method further includes the steps of... Agent: Rader Fishman & Grauer PLLC
20100209960 - Method for measuring mitochondrial membrane potential in vertebrate cells: The present invention relates to homogenous fluorescence-based assays for measuring mitochondrial membrane potential in vertebrate cells. The assays use an inner filter such as Brilliant Black BN to quench non-specific fluorescence. The assays are particularly suited for ultra high-throughput screening for activators of mitochondrial uncoupling proteins, chemical uncouplers, compounds with... Agent: Merck
20100209958 - Method of treating arthritis and promoting growth of articular chondrocytes: This invention provides a new therapeutic or prophylactic agent for arthritis such as osteoarthritis. Specifically, it provides a therapeutic or prophylactic agent for arthritis such as osteoarthritis, or an agent for promoting the growth of articular chondrocyte, comprising a guanyl cyclase B (GC-B) activator as an active ingredient; or a... Agent: Birch Stewart Kolasch & Birch
20100209961 - Microorganism concentration process and agent: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof; (b) providing... Agent: 3m Innovative Properties Company
20100209963 - Photo-electric device and method for high throughput activation, guidance and poration of targeted cells with high spatial resolution: The method includes the steps of generating a spatially and/or temporally localized electric field generated on the photoconductive surface, and selectively activating, guiding or porating targeted (excitable) cells at high throughput with high spatial resolution, applied for example to neurons, cardiac and muscle cells. The spatially and/or temporally localized electric... Agent: Law Offices Of Daniel L. Dawes Dawes Patent Law Group
20100209962 - Tetranor pgdm: a biomarker of pgd2 synthesis in vivo: The present invention relates to a prostaglandin D2 metabolite, derivatives thereof, compositions comprising the metabolite, and an antibody that specially binds to the metabolite. Methods of use are also provided.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20100209959 - Tumour-cell-fixing cells: The present invention relates to an isolated cell capable of fixing tumour cells, expressing the CD10 protein and expressing at least one MDR protein, and to the use of this cell for screening for anti-tumour compounds.... Agent: Young & Thompson
20100209966 - Aseptic bioreactor system for processing biological materials: A bioreactor system according to one embodiment of the present invention is provided for producing and processing a biological material in an aseptic environment. For example, the system includes at least one culture tube configured to hold a liquid media containing a biological material and at least one flexible bag... Agent: Alston & Bird LLP
20100209965 - Catalytic pyrolysis of fine particulate biomass, and method for reducing the particle size of solid biomass particles: A process is disclosed for converting a particulate biomass material to a bioliquid. In the process the biomass material is mixed with a heat transfer medium and a catalytic material, and heated to a temperature in the range of from 150 to 600° C. The particle size of the solid... Agent: Kior Inc.
20100209967 - Process for the synthesis of 9a-hydroxy-steroids: The present invention relates to a novel selective synthesis of 9α-hydroxy-steroid derivatives of the general formula (I) (I)—wherein the meaning of -A-A′- is —CH2—CH2— or —CH═CH— group—by the bioconversion of compounds of the general formula (II) (II) wherein the meaning of -A-A′- is —CH2—CH2— or —CH═CH— group—by using Nocardia farcinica... Agent: Kf Ross PC
20100209968 - Immobilized enzymes and uses thereof: The present invention generally relates to uses of immobilized enzymes. Immobilized enzymes can be used for various chemical transformations, separations, and purifications and can be used in sensors and diagnostics... Agent: Senniger Powers LLP
20100209969 - Geraniol synthase, methods of production and uses thereof: The present invention relates to novel type of monoterpene synthase, a key enzyme in the production of the monoterpene aroma compound geraniol. More specifically, the present invention relates to nucleic acid sequences coding for GES from flowers and herbs species, in particular sweet basil, as well as to vectors containing... Agent: Harness, Dickey & Pierce, P.L.C
20100209973 - Dried composition for hot-start pcr with long-term stability: The present invention relates to a dried composition for hot-start PCR, more precisely a dried composition for hot-start PCR with improved stability and long-term storagability which is characteristically prepared by the steps of preparing a reaction mixture by mixing an aqueous solution containing reaction buffer, MgCl2, 4 types of dNTPs,... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100209971 - Generation of nucleic acid molecules: The present invention relates generally to methods for generating single stranded nucleic acid molecules following enhanced solid phase polynucleotide amplification. The present invention employs an amplification reaction using primers with differential priming properties at particular annealing conditions or an immobilized primer nested between two aqueous phase primers. Thus, by primer... Agent: Knobbe Martens Olson & Bear LLP
20100209972 - Method for synthesis of single- or double-stranded dna, and kit for the synthesis: An object of the present invention is to provide a simple and safe method for synthesis of single-stranded or double-stranded DNA and a kit for performing the synthesis. The present invention relates to, (1) a method for synthesis of single-stranded DNA, comprising a nucleotide sequence corresponding to the template RNA,... Agent: Leydig Voit & Mayer, Ltd
20100209970 - Method of amplification of gc-rich dna templates: Methods are provided for increasing the processivity of DNA polymerases on GC-rich templates. The methods relate to providing enhancers and biased ratios of dNTPs, and may be used in DNA amplification reactions. The methods are useful for detecting genotypes associated with GC-rich repeats, including Fragile X Syndrome.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20100209974 - Non-replicating paramyxoviridae virus vector: The present inventors succeeded in producing non-replicating SeV vectors whose genomic RNAs lack all genes for the NP, P, and L proteins, which are RNP-constituting proteins. The present inventors confirmed that the NP/P/L-deficient SeV vectors carrying a marker gene such as GFP provide high productivity, and high transfer and expression... Agent: Clark & Elbing LLP
20100209975 - Multi-component inhibitors of nucleic acid polymerases: The present invention provides multi-component inhibitors of nucleic acid polymerases, methods of making, and methods of using same. One component of the multi-component inhibitor is a molecule that binds to a polymerase (i.e., a polymerase-binding molecule (PBM)), but does not thereby substantially inhibit its polymerase activity. Another component is a... Agent: Life Technologies Corporation C/o Intellevate
20100209976 - Method of pre-treating and saccharifying algae biomass: Disclosed is a method of pre-treating and saccharifying an algae biomass, by dehydrating the algae biomass to have a water content of about 10% to about 70% by weight, cutting the algae biomass having a water content of about 10% to about 70% by weight to a predetermined size, and... Agent: Cantor Colburn, LLP
20100209977 - L-amino acid-producing bacterium and a method for producing an l-amino acid: A bacterium belonging to the family Enterobacteriaceae, which has an ability to produce an amino acid such as L-cysteine and has been modified to have specific mutation in the yeas gene, is cultured in a medium, and the L-amino acid is collected from the medium.... Agent: Cermak Nakajima LLP Acs LLC
20100209978 - Gene-disrupted strain, recombinant plasmids, transformants and process for production of 3-carboxymuconolactone: Industrial-scale fermentative production of 3-carboxy-cis,cis-muconic acid from terephthalic acid. Also, a protocatechuate 4,5-ring-cleaving enzyme gene-disrupted strain in which the gene coding for (a) the amino acid sequence set forth in SEQ ID NO: 1 or 3, or (b) the amino acid sequence set forth in SEQ ID NO: 1 or... Agent: Locke Lord Bissell & Liddell LLP Attn:IPDocketing
20100209979 - Method of manufacturing glycerol carbonate: Disclosed is a method of manufacturing a glycerol carbonate (GC). The method includes a bio-catalyst reaction for generating the GC and byproducts generated by reacting a reactant solution using a lipase of a bio-catalyst. In this instance, the reactant solution is prepared by adding glycerol, a glycerol-containing composition, or a... Agent: Reinhart Boerner Van Deuren P.C.
20100209980 - Method for producing optically active aminoalkylphenols: The invention relates to a method for the enantioselective N-acylation of aminoalkylphenols, and to a method for producing enantiomer-pure compounds of formulae (I-S) and/or (I-R).... Agent: Connolly Bove Lodge & Hutz, LLP
20100209981 - Transaminase polypeptides: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of... Agent: Dechert, LLP
20100209982 - Modified-immobilized enzymes of high tolerance to hydrophilic substrates in organic media: Disclosed are preparations of modified interfacial enzymes, particularly lipases and phospholipases, immobilized on a solid support, wherein the enzyme is surrounded by hydrophobic microenvironment, thereby protected from deactivation and/or aggregation in the presence of hydrophilic agents, substrates and/or reaction products. The enzyme may be protected by being covalently bonded with... Agent: David S. Resnick
20100209983 - Preparing method for (s)-3hydroxybutyric acid and (s)-3 hydroxybutyrate ester using recombinant microorganism: Accordingly, (S)-3-hydroxybutyric acid with high optical purity may be produced from acetyl CoA produced in glycolysis of a microorganism by a simple process involving the manipulation of a metabolic pathway by a recombinant gene introduced into the microorganism without using a high-cost metal catalyst or a substrate. Further, (S)-3-hydroxybutyrate ester... Agent: Mckenna Long & Aldridge LLP
20100209984 - Process for the preparation of dihydroxy esters and derivatives thereof: wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy... Agent: Morgan Lewis & Bockius LLP
20100209985 - Novel esterases and their use: The present invention relates to polyesterases having cutinase and/or suberinase activity obtainable from Coprinus and Trichoderma. The invention further relates to a method for producing the polyesterases, and to polynucleotides, vectors and host cells used therein. The enzymes are useful in hydrolysing cutin, suberin and other polyesters for example in... Agent: Birch Stewart Kolasch & Birch
20100209986 - Biofuel production by recombinant microorganisms: Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol and 2-phenylethanol from a suitable substrate.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP
20100209987 - Method for isolating proteins or protein and nucleic acid associations, or particle and protein complexes, reagent and uses: The magnetic colloidal particles comprise a core and an envelope in which the core is magnetic and is coated with at least one polymer comprising functional groups X chosen from amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups, or mixtures thereof, at least one... Agent: Oliff & Berridge, PLC
20100209988 - Bioremediation materials: Microbially colonised charred biological material, such as charcoal, wherein the colonising microbes are capable of metabolising at least one selected environmental substance, such as a pollutant, and wherein a selective amount of the substance is present in the charred material provide protected colonies of environmentally active microbes useful in bioremediation,... Agent: Foley & Lardner LLP
20100209989 - Entrapping immobilization pellets and process for producing the same: The present invention produces entrapping immobilization pellets which have high pellet strength and retain high and stable microbial activity (nitrification activity) even if a low concentration of a material involved in immobilization (such as an immobilizing material or polymerization initiator) used. The entrapping immobilization pellets in which microorganisms are entrapped... Agent: Oliff & Berridge, PLC
20100209990 - 11 beta hydroxysteroid dehydrogenase type 1: The invention provides gene-targeted non-human animals comprising a genetically modified 11βHSD1 gene encodes a mutant 11βHSD1 polypeptide which is modulated by human 11βHSD1 modulating compounds. The invention further provides cells expressing mutant 11βHSD1 and cells isolated from gene-targeted animals, which cells produce a mutant 11βHSD1. The invention further provides methods... Agent: Louis J. Wille Bristol-myers Squibb Company
20100209991 - Ionic liquids derived from functionalized anionic surfactants: A novel class of ionic liquids and methods for their preparation are disclosed. Specifically, these novel ionic liquids can be derived from anionic surfactants, such as alkyl aryl sulfonates, and mid-chain branched derivatives of alkyl sulfates, alkyl alkoxy sulfates, and alkyl aryl sulfonates. In addition, novel ionic liquids can be... Agent: The Procter & Gamble Company Global Legal Department - Ip
20100209992 - Process for the production of a catalyst preparation and use of the catalyst preparation: A process is described for the production of a catalyst preparation, in which the catalyst containing at least one inorganic compound which is solid under standard conditions is comminuted by means of a dispersion unit into particles having a maximum average particle size d50.3 of 2 μm, preferably a maximum... Agent: Fulbright & Jaworski, LLP
20100209993 - Permanent inactivation of nucleases: The present invention relates to the use of reagent for permanently inactivating nucleases wherein the reagent comprises an oxidizing agent, a protein denaturant and optionally a pH adjustor and to a method for permanently inactivating nucleases using said reagent.... Agent: Seed Intellectual Property Law Group PLLC
20100209994 - Protein surface remodeling: Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to more hydrophilic residues (e.g., charged amino acids).... Agent: Harvard University & Medical School C/o Wolf, Greenfield & Sacks, P.C.
20100209995 - Amylases, nucleic acids encoding them and methods for making and using them: In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of starch... Agent: Verenium Corporation Intellectual Property Department
20100209996 - Thermostable alpha-amylases:
20100209997 - Carbonic anhydrase polypeptides and uses thereof: The present disclosure relates to recombinant carbonic anhydrase enzymes having improved properties as compared to a naturally-occurring wild type carbonic anhydrase and uses thereof for the sequestration of carbon dioxide as well as for the release of carbon dioxide from a composition comprising bicarbonate. Also provided are polynucleotides encoding the... Agent: Codexis, Inc.
20100209998 - Cell-permeabilising peptides and polypeptides for microbial cells: Signal peptides and polypeptides from Methanobrevibacter ruminantium, a methanogenic archaea present in ruminants. Methods of using these peptides to permeabilise microbial cells, particularly M. ruminantium strain M1τ (DSM 1093).... Agent: Baldwins
20100209999 - Phage Ømru polynucleotides and polypeptides and uses thereof: The invention encompasses phage φmru including phage induction, phage particles, and the phage genome. Also encompassed are phage polypeptides, as well as polynucleotides which encode these polypeptides, expression vectors comprising these polynucleotides, and host cells comprising these vectors. The invention further encompasses compositions and methods for detecting, targeting, permeabilising, and... Agent: Baldwins
20100210000 - Probiotic grain-based compositions: The present application relates to probiotic grain-based compositions comprising lactic acid-producing bacteria.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100210001 - Biomass cultivating installation and method: The invention relates to a biomass cultivating installation (1) comprising a container (7) for receiving a solution containing biomass, at least one optical wave guide (8) guided in the container (7), for supplying light energy to the aqueous solution containing biomass, and a controllable light distributor (6) width is coupled... Agent: Whitham, Curtis & Christofferson & Cook, P.C.
20100210003 - System and related method for concentrating biological culture and circulating biological culture and process fluid: A system and related method for concentrating biological culture and circulating biological culture and process fluid is provided. The system includes a continuous flow separator that removes excess fluid from the culture medium, resulting in a “concentrated medium” of fluid. The concentrated medium is then passed along for further processing... Agent: Tsircou Intellectual Property Law
20100210002 - Use of plant growth regulators to enhance algae growth for the production of added value products: The invention provides methods that enhance the production of biomass from algae that grow autotrophically, heterotrophically, or photoheterotrophically, through the use of plant growth regulators (such as growth hormones, indole acidic acid, etc.) and hormone mimics (phenoxyacetic compounds, etc.). The plant growth regulators or mimics thereof may further increase the... Agent: Mccarter & English, LLP Boston
20100210004 - Plasmodium axenic liver stages as a noninfectious whole organism malaria vaccine: The present invention relates to the treatment and prevention of malaria infection. In particular, the present invention provides novel noninfectious, whole organism vaccines for malaria, which vaccines comprise a Plasmodium axenic liver stage. The invention also provides methods to treat and prevent malaria by administering such Plasmodium axenic liver stage... Agent: Darby & Darby P.C.
20100210005 - Carbon sequestration using a floating vessel: Disclosed is a method for removing carbon dioxide from the atmosphere. The method comprises the step of delivering urea from a floating vessel to a region of a photic zone of the ocean, whereby the number of phytoplankton is caused to increase in the region upon addition of the urea.... Agent: Fish & Richardson PC
20100210006 - Thermal array: Traditional thermocyclers are heating devices that change sample temperatures by adding heat energy into a sample block that is usually a large metal block and then extracting that heat energy out of the block in a process called ramping the temperature. Presented herein is a technology that eliminates the large... Agent: Frank Spangler
20100210007 - Automatic analyzer: Disclosed is an automatic analyzer that analyzes a component of a target layer of a test sample separated into a plurality of layers by transferring the component from an installed container, comprising: a dispensing probe that descends into the target layer and suctions the component; a detecting unit that detects... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100210008 - Configurable microfluidic substrate assembly: A microfluidic substrate assembly includes a substrate body having at least one fluid inlet port. At least one microscale fluid flow channel in the substrate is in fluid communication with the inlet port for transport of a fluid to be tested. The substrate body also has a plurality of sockets,... Agent: Banner & Witcoff, Ltd.
20100210009 - Optical microlabels: shapes and reflectors: Labels and methods of producing labels for use in clinical, analytical and pharmaceutical development assays are provided. Labels may comprise shape-encoded particles which may be coupled to ligands such as DNA, RNA and antibodies, where different shapes are used to identify which ligand(s) are present. Labels may also comprise reflectors,... Agent: Robert W Strozier, P.l.l.c
20100210010 - Sample processor: An integral magnet and heater device comprising a heating element with integral permanent magnet for use in a sample preparation or analysis apparatus. Also disclosed is a sheath adapted to cover a reusable processing component, such as a heater or sonicator, of an apparatus during use. Other associated aspects of... Agent: Polsinelli Shughart PC
20100210011 - Marking ear tag comprising a tissue sampling device: An ear tag for identifying animals, enables a sample of biological tissue to be taken when the tag is applied to the animal. The tag includes a male part and a female part which are assembled by irreversible socketing. The stem of the male part includes a detachable head having... Agent: Young & Thompson
20100210012 - Purified mammalian cytokines; related reagents and methods: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.... Agent: Merck Patent Department (k-6-1, 1990)
20100210014 - Nuclear reprogramming factor and induced pluripotent stem cells: The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including... Agent: Greenblum & Bernstein, P.L.C
20100210013 - Postpartum cells derived from umbilical cord tissue, and methods of making and using the same: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.... Agent: Patton Boggs LLP
20100210015 - Photochemical activation of surfaces for attaching biomaterial: A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the... Agent: Ratnerprestia
20100210016 - Rotation system for cell growth chamber of a cell expansion system and method of use therefor: A system and method for rotating a cell growth chamber of a cell expansion system includes a rotatable member for engaging a chamber coupling attached to the cell growth chamber. The rotatable member includes an independently operable mechanism for engaging a rotatable fitting associated with the chamber coupling. In at... Agent: Holme Roberts & Owen LLP
20100210017 - Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms: Embodiments herein generally relate to methods, compositions and uses for enhancing tolerance of production of organic acids and alcohols by microorganisms. This application also relates generally to methods, compositions and uses of vectors having one or more genetic element to increase the tolerance of organic acids or alcohols by a... Agent: Wilson, Sonsini, Goodrich & Rosati
20100210018 - Microbial host-vector complementation system: This invention provides a host-vector complementation system, which permits selection of vector-carrying host cells, without requiring an antibiotic resistance gene. In some embodiments, this system utilizes a host which is guaB deficient and vectors that carry and express the guaB gene. The invention also discloses methods of making and using... Agent: Ratnerprestia08/12/2010 > patent applications in patent subcategories.
20100203495 - Processing biomass: Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce a product or intermediate, e.g., energy, a food, a... Agent: Xyleco, Inc. Celia Leber
20100203501 - Assay to detect hcv receptor binding: Identification of HCV receptor target cells using HCV receptor-binding ligands and cell separation by flow cytofluorimetry is described. HCV receptor target cells are employed to conduct assays for HCV receptor-binding ligands in order to identify potential HCV vaccine candidates. HCV receptor target cells are used to measure antibody neutralisation to... Agent: Novartis Vaccines And Diagnostics Inc.
20100203499 - Electrophoretic interactive spectral methods and devices for the detection and/or characterization of biological particles: Methods for identifying a biological particle in a sample medium include generating an Electrophoretic Quasi-elastic Light Scattering (EQELS) spectrum for the biological particle in the sample medium. The EQELS spectrum is compared to a reference database comprising a plurality of spectra, and each of the plurality of spectra correspond to... Agent: Myers Bigel Sibley & Sajovec
20100203496 - Fluorescent multiplex hpv pcr assays: The present invention relates a fluorescent multiplex PCR assay for detecting the presence of a nucleic acid sequence of an HPV type in a sample using multiple fluorophores to simultaneously detect a plurality of HPV genes of the same HPV type, wherein the HPV type is selected from the group... Agent: Merck
20100203500 - Method for detection of hop latent virus, primer set for the detection, and kit for the detection: The invention provides a detection method for hop latent virus that comprises an extraction step in which hop latent virus RNA is extracted from a specimen, an amplification step in which a primer set containing 4 different oligonucleotides consisting of the nucleotide sequences represented by SEQ ID NO: 1-4 of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100203498 - Methods and compositions for identifying anti-hcv agents: The invention provides methods and compositions for identifying agents for treating infection by viruses that encode a nucleotide-binding NS4B protein, or functional equivalent thereof, e.g., hepatitis C virus (HCV) or other members of the family Flaviviridae. In general, the methods involve contacting an NS4B nucleotide binding motif (NBM)-containing polypeptide with... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP
20100203497 - System and method for detection of hiv drug resistant variants: In one embodiment of the invention a method for detecting low frequency occurrence of one or more HIV sequence variants associated with drug resistance is describe that comprises generating cDNA species from RNA molecules in an HIV sample population; amplifying first amplicons from the cDNA species, wherein each amplicon comprises... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo
20100203546 - Allele determining device, allele determining method and computer program: According to an allele determining device 1 that determines a single nucleotide polymorphism of a gene, an approximating unit 4 approximates an optical measurement result obtained by observing a reagent that reacts with a specific base sequence of a gene, to a logistic curve that is a curve using light... Agent: Squire, Sanders & Dempsey L.L.P.
20100203543 - Biological encoding of large numbers of cells: Mixtures of cell types can be analyzed by having at least two signal markers, with at least one at three different levels to provide a barcode for each cell type. The mixture of cells may be subjected to a common candidate moiety and the effect of the moiety on the... Agent: Robins & Pasternak
20100203516 - Detecting analytes using both an optical and an electrical measurement method: Provided is a method for detecting an analyte, wherein the analyte is labelled with one or more labels relatable to the analyte, which method comprises: a) performing an optical detection method on the labelled analyte to obtain optical data from the one or more labels; b) performing an electrical detection... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP
20100203525 - Detection of gene duplications: Methods of detecting a candidate genetic anomaly such as a candidate duplication in a genome are disclosed. The methods comprise quantifying fluorogenic assays for alleles of a genetic locus from a plurality of individual genomes, identifying ranges of fluorescent intensities indicative of individual genomes homozygous for a first allele, homozygous... Agent: Life Technologies Corporation C/o Intellevate
20100203515 - Detection of gene expression in cells by scanning fcs: The present invention relates to a method for determination of an analyte in a cell by fluorescent correlation spectroscopy.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100203538 - Determination of copy number differences by amplification: The present invention provides for determining relative copy number difference for one or more target nucleic acid sequences between a test sample and a reference sample or reference value derived therefrom. The methods facilitate the detection of copy number differences less than 1.5-fold.... Agent: Weaver Austin Villeneuve & Sampson LLP
20100203544 - Diagnosis and treatment of cancers with microrna located in or near cancer associated chromosomal features: MicroRNA genes are highly associated with chromosomal features involved in the etiology of different cancers. The perturbations in the genomic structure or chromosomal architecture of a cell caused by these cancer-associated chromosomal features can affect the expression of the miR gene(s) located in close proximity to that chromosomal feature. Evaluation... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20100203548 - Diagnostic method for epilepsy: c
20100203536 - Diagnostics of b-cell lymphoma: The present invention relates to the fields of genetics and oncology and provides methods and means for diagnosing and monitoring of patients having B-cell lymphomas, such methods and means allowing an early diagnosis of the B-cell lymphoma. Specifically, the present invention relates to a novel method and a biomarker for... Agent: Ladas & Parry LLP
20100203505 - Dopaminergic neuron proliferative progenitor cell marker msx1/2: The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can... Agent: Townsend And Townsend And Crew, LLP
20100203537 - Dual oligonucleotide method of nucleic acid detection: Methods for amplifying and detecting nucleic acids are described, as well as sets of 5′ labeled oligonucleotides.... Agent: 3m Innovative Properties Company
20100203532 - Enrichment of a target sequence: The present invention is directed to methods, compositions, software and devices for enriching low abundance alleles from a sample. The method is based in part on a modified nucleic acid amplification protocol that includes incubating the reaction mixture at a critical denaturing temperature or “Tc”. By employing the present invention... Agent: Andrus, Sceales, Starke & Sawall, LLP
20100203535 - Genetic analysis: The present invention provides methods for excluding a gene as being involved in, associated with or causative of a genetic disorder in a family.... Agent: Winstead PC
20100203503 - Genetic polymorphisms associated with myocardial infarction and uses thereof: A genetic polymorphism associated with myocardial infarction is provided. More particularly, provided are a polynucleotide including a single nucleotide polymorphism (SNP) or a haplotype associated with myocardial infarction, a polynucleotide hybridized with the polynucleotide, a polypeptide encoded by one of the polynucleotides, an antibody bound to the polypeptide, a microarray... Agent: Cantor Colburn, LLP
20100203517 - Human diabetes susceptibility pebp4 gene: The present invention relates to a diagnostic method of determining whether a subject, preferably an obese subject, is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the PEBP4 gene locus in a biological sample of said subject.... Agent: Occhiuti Rohlicek & Tsao, LLP
20100203509 - Inducible fluorescently-tagged protein expression system: The present invention is related to an antibiotic inducible/repressible genetic construct for controlling transcription of a gene of interest in a cell, and methods for its use. The genetic construct provides a plasmid vector comprising a polynucleotide molecule, two tetO sequences, and a single CMV promoter, wherein the polynucleotide molecule... Agent: Adams And Reese LLP
20100203523 - Means and methods for classifying samples of multiple sclerosis patients: The invention in one aspect provides a method for classifying cells from a human individual said method comprising: providing a sample comprising cells from said individual that are typically responsive to exposure to a type I interferon; determining a level of activity of a pathway that is modulated by type... Agent: Nixon & Vanderhye, PC
20100203526 - Mecp2e1 gene: The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20100203547 - Method for accessing the contents of a closed vessel containing a specimen retrieval device: Method for obtaining a fluid from a collection device assembled to isolate a specimen retrieval device from the pathway of a fluid transfer device used to penetrate a cap of the collection device and to draw and remove the fluid from the collection device for analysis.... Agent: Gen Probe Incorporated
20100203521 - Method for bacterial lysis: The present invention is directed to a microfluidic device for lysis of cells, such as bacteria and microorganisms. In particular, the present invention relates to microfluidic devices and methods of manufacture of such microfluidic devices comprising a substrate with at least one channel packed with a polymer monolith embedded with... Agent: Ronald I. Eisenstein
20100203512 - Method for renal disease diagnosis and prognosis using annexin a1 and rab23 as markers: Use of Annexin A1 or Rab23 as a biomarker for diagnosing kidney disease or assessing efficacy of kidney disease treatment.... Agent: Occhiuti Rohlicek & Tsao, LLP
20100203519 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20100203520 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20100203502 - Method for the in vitro detection of a predisposition to the development of alterations in ovarian function: The invention relates to a method for the in vitro detection of a predisposition to the development of alterations in ovarian function. The inventive method is based on the detection of polymorphisms −673C>T, −9C>G, IVS1+905A>G and N103S of gene BMP15 and combinations of same. The invention can be used for... Agent: Ladas & Parry LLP
20100203542 - Method for treating autoimmune diseases and screening method for preventive or therapeutic agent for the same: A screening method for a preventive or therapeutic agent for an autoimmune disease and/or for an apoptosis inhibitor, comprising determining retinoblastoma associated protein (RBAp48) production suppressing effect or RBAp48 production inhibitory effect of a sample.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100203522 - Method to predict or diagnose a gastrointestinal disorder or disease: The disclosure provides methods and compositions useful for identifying a subject's predisposition to a gastrointestinal disease or disorder.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP
20100203514 - Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.... Agent: Davis Wright Tremaine, LLP/seattle
20100203529 - Methods and systems of using exosomes for determining phenotypes: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific... Agent: Wilson Sonsini Goddrich & Rosati/ Caris Life Sciences
20100203539 - Methods for predicting methotrexate polyglutamate levels using pharmacogenetics: The present invention provides methods for determining a level of methotrexate polyglutamates (MTXPGs) in an individual undergoing methotrexate (MTX) therapy and for optimizing dose efficacy of MTX therapy in an individual by genotyping the individual at a polymorphic site in at least one folate pathway gene (e.g., a reduced folate... Agent: Cooley LLP Attn: Patent Group
20100203507 - Methods of predicting methotrexate efficacy and toxicity: The present invention provides methods for analyzing genetic and/or metabolite biomarkers to individualize methotrexate (MTX) therapy. For example, the assay methods of the present invention are useful for predicting whether a patient will respond to MTX and/or has a risk of developing toxicity to MTX based upon the genotype of... Agent: Cooley LLP Attn: Patent Group
20100203508 - Methods of predicting methotrexate efficacy and toxicity: The present invention provides methods for analyzing genetic and/or metabolite biomarkers to individualize methotrexate (MTX) therapy. For example, the assay methods of the present invention are useful for predicting whether a patient will respond to MTX and/or has a risk of developing toxicity to MTX based upon the genotype of... Agent: Cooley LLP Attn: Patent Group
20100203513 - Microrna as biomarker in cancer: The present invention relates to the discovery of certain microRNAs that correlate with certain information regarding cancer. The microRNAs of the invention are selected from the group consisting of hsa-miR-15b, hsa-miR-181b, hsa-miR-191, hsa-miR-200c, and hsa-let-7g. If the expression of these microRNAs is increase, then the increased expression of these microRNAs... Agent: The Webb Law Firm, P.C.
20100203541 - Nucleotide analogs: The disclosure provides nucleotide analogs and methods of their use. Analogs of the invention comprise a reporter molecule (label) attached via the N4, N6, O4, or O6 position of the nitrogenous base portion of the analog. In a preferred embodiment, nucleotide analogs of the invention comprise a label attached to... Agent: Brown Rudnick LLP
20100203524 - Polymerases and methods of use thereof: The invention generally relates to polymerases for efficient and controlled sequencing-by-synthesis reactions. In certain embodiments, the invention provides a polymerase enzyme including at least one mutation that enhances ability of the polymerase as compared to a wild-type polymerase to incorporate a nucleotide into a nascent strand of DNA or cDNA... Agent: Brown Rudnick LLP
20100203533 - Polymerized conjugates for biological applications: Polymerized conjugates of at least two proteins that have increased sensitivity for detecting proteins in biological assays such as gels and blots, and methods of preparing the conjugates, and a protein assay detection kit using the conjugates. In one embodiment, proteins are polymerized by reacting a carbohydrate group on the... Agent: Thompson Hine L.L.P. Intellectual Property Group
20100203510 - Ppia marker for diagnosis of liver cancer and antibody, and screening method of compounds useful for inhibiting liver cancer: Disclosed is a marker for diagnosis of liver cancer comprising polynucleotide useful for diagnosis of liver cancer. The marker for liver cancer diagnosis comprises at least one polynucleotide selected from a group consisting of the following polynucleotides (a) to (d):(a) polynucleotide having a base sequence defined by Seq. No. 1... Agent: The Nath Law Group
20100203531 - Predicting responsiveness to temozolomide: This document features methods and materials involved in predicting responsiveness of a mammal (e.g., human) having cancer (e.g., glioblastoma multiforme) to treatment with chemotherapy (e.g., temozolomide). For example, methods and materials for using the methylation status at one or more CpG methylation sites (e.g., CpG 89) in O6-methylguanine methyl-transferase nucleic... Agent: Fish & Richardson P.C.
20100203527 - Process for identifying fish signals: Among embodiments is disclosed a process for immunostaining a sample such that the stain is stable under FISH conditions.... Agent: Kelley Drye & Warren LLP
20100203518 - Quantitative assay for the simultaneous detection and speciation of bacterial infections: An adaptation of the real-time PCR assay allows for highly sensitive detection of any eubacterial species with simultaneous speciation. The assay relies on a ‘multiprobe’ design in which a single set of highly conserved sequences encoded by the 16S rRNA gene serves as the primer pair, and it is used... Agent: Banner & Witcoff, Ltd.
20100203511 - Retinoid metabolizing protein: Amino acid sequences and corresponding nucleic acid sequence of retinoid metabolizing protein found in human, mouse and zebrafish are described, as well as methods of using same.... Agent: Dowell & Dowell P.C.
20100203504 - Substance-information acquisition method using evanescent light beam, substance-information measurement apparatus, base-sequence determination method and base-sequence determination apparatus: Information on the position and displacement of a detection-subject substance T can be presented by adoption an evanescent light illumination technology. An evanescent light beam PE has a property that the intensity thereof abruptly attenuates in accordance with an exponential function with increases in distance Z from a boundary surface... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20100203528 - System for obfuscating identity: Compositions, apparatus, systems, kits, and methods for obfuscating the nucleic acid and/or protein content of an environment.... Agent: The Invention Science Fund Clarence T. Tegreene
20100203530 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: The Invention Science Fund Clarence T. Tegreene
20100203545 - Two-color real-time/end-point quantitation of micrornas (mirnas): The present invention is directed to methods, reagents, kits, and compositions for detecting target polynucleotide sequences, especially small target polynucleotides such as miRNAs, between two samples. A pair of linker probes can be employed in two different reactions to query a particular species of target polynucleotide. A pair of detector... Agent: Life Technologies Corporation C/o Intellevate
20100203534 - Use of polynucleotides for detecting gene activites for distinguishing between local and systemic infections: The present invention concerns the use of polynucleotides having a length of 2 to 100% of the number of nucleotides of the single sequences according to SEQ ID No. 1 to SEQ ID No. 69 and/or their gene loci and/or their transcripts for detecting gene activities for the differentiation of... Agent: Lewis Kohn & Fitzwilliam LLP
20100203506 - Viral variants and methods for detecting same: The present invention relates generally to viral variants exhibiting reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components. The present invention further contemplates assays for detecting... Agent: Nixon & Vanderhye, PC
20100203549 - Calibrated rpma assay: This invention relates, e.g., to a set of calibrants for determining the amount in a sample of an analyte (e.g., a protein, such as a protein that has been post-translationally modified), comprising a plurality of calibrants, which contain a range of amounts (e.g., defined amounts and/or serial dilutions) of the... Agent: The Law Office 0f Geoffrey M. Karny
20100203550 - Method of performing an immunoassay in blood: a second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)
20100203551 - Monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medial products: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests... Agent: Marshall, Gerstein & Borun (baxter)
20100203552 - Interaction of bim with trim2: Methods, compositions, and cells for drug screening based on interaction between a Bim polypeptide and a TRIM2 polypeptide. Methods and compositions for treating cancer based on tested levels of Bim and TRIM2 proteins are also provided.... Agent: Kolisch Hartwell, P.C.
20100203556 - Methods of using a g protein-coupled receptor to identify peptide yy (pyy) secretagogues and compounds useful in the treatment of conditions modulated by pyy: The present invention relates to methods of using GPR119 receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY, such as conditions modulated by stimulation of NPY Y2 receptor (Y2R). Agonists of GPR119 receptor are useful as therapeutic agents for treating or... Agent: Fish & Richardson P.C.
20100203557 - Monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medial products: An improved monocyte activation test is described that is better able to detect non-endotoxin pyrogens in medical products, in which a sample is incubated with a monocyte-containing reagent in an assay system comprising at least one surface comprising polypropylene. The invention also concerns assay systems for use in these tests... Agent: Marshall, Gerstein & Borun (baxter)
20100203554 - Generic kinase/phosphatase assay with single readout: The present invention relates to a generic method for detecting a kinase or phosphatase activity. The method comprises the following steps: incubating a kinase or phosphatase activity sample with a kinase or phosphatase substrate molecule comprising either a fluorophore having a detectable readout or molecule with an aromatic group which... Agent: Hoffmann-la Roche Inc. Patent Law Department
20100203553 - Histochemical and biomarker for liver fibrosis: The histochemical and biomarker for liver fibrosis is a technique for determining the existence and extent of liver fibrosis by evaluating the extent of peptidylarginine deiminase (PAD) activity by immunological methods. The method is illustrated using liver biopsy. A small section of tissue from a liver biopsy is incubated overnight... Agent: Litman Law Offices, Ltd.
20100203555 - Wild-type receptor assays: A method for determining ligand activation of receptors using cells expressing genetic constructs of a fusion protein of at least a binding domain of an auxiliary protein and a fragment of β-galactosidase, a fusion protein of an endosome-associated protein and a complementary fragment of β-galactosidase, and a wild-type receptor. The... Agent: Peters Verny , L.L.P.
20100203559 - Immuno-based botulinum toxin serotype a activity assays: The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A... Agent: Allergan, Inc.
20100203558 - Method and immune absorbents for the specific detection and absorption of celiac disease-and herpetiform dermatitis-associated antibodies: The present invention relates to fusion peptides that are derived from components of gliadin, to a method and reagents for the serological diagnosis of celiac disease or dermatitis herpetiformis by way of assaying antibodies that are directed against modified gliadin. The invention also relates to methods and pharmaceutical compositions for... Agent: Seed Intellectual Property Law Group PLLC
20100203560 - Immunoassay for quantification of an unstable antigen selected from bnp and probnp: The present invention relates to an immunoassay for detection of BNP, proBNP and fragments thereof. Essentially the assay comprises: a) contacting the antigen with a first antibody specific to a fragment corresponding to amino acids 11-22 of BNP, or to a part of this peptide comprising at least three amino... Agent: Birch Stewart Kolasch & Birch
20100203561 - Method for using division arrested cells in screening assays: Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.... Agent: Life Technologies Corporation C/o Intellevate
20100203562 - Plasma filtration: The invention relates to a process for preparing blood plasma for determining one or more blood parameters, in particular coagulation parameters. In order to improve the measurement, the blood plasma is sucked through a filter by means of reduced pressure.... Agent: Kf Ross PC
20100203563 - Systems and methods for analyzing persistent homeostatic perturbations: This invention is in the field of homeostasis analysis. More particularly, it relates to systems and methods for analyzing persistent homeostatic perturbations, i.e. chronic stress, by measuring levels of biomarkers that are related to chronic stress. This invention is also directed to systems and methods for analyzing the molecular mechanisms... Agent: Dla Piper LLP (us)
20100203564 - Fluorescent phospholipase a2 indicators: Compositions, methods of synthesis and applications of phospholipase A2 (PLA2) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA2 specific... Agent: Life Technologies Corporation C/o Intellevate
20100203566 - Methods for the detection and monitoring of congestive heart failure: Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart failure can be of any etiology, such as systolic or diastolic heart failure, ischemic or non-ischemic cardiomyopathy.... Agent: Cantor Colburn, LLP
20100203565 - Peptide fingerprint from the degradation of elastin by hne: Methods for producing and using protein/peptide fingerprints, derived from elastin degraded by the enzyme human Neutrophil Elastase (HNE), allowing identification and investigation of disease-associated proteins/peptides that can be linked to specific drug targets, or to specific drug target combinations. The methods are particularly useful for studies relating to Chronic Obstructive... Agent: Connolly Bove Lodge & Hutz, LLP
20100203567 - Esbl detection kit and method: The invention provides methods and detection kits for detecting extended spectrum β-lactamase producers (ESBLs). The kits typically comprise a carrier containing: a)at least one sugar; b) at least one antibiotic for killing Gram positive bacteria; c) at least one antifungal compound; d) a mixture of cefpodoxime and at least one... Agent: Smith, Gambrell & Russell
20100203578 - Apparatus and methods for separating and analyzing components in fluids: Provided are methods and devices for separating particulate analytes or aggregates of analytes from a fluid, after the separation medium of the device is saturated with the fluid. The endpoint indicating completion of the separation is determined by saturation; therefore, no precise metering of the fluid sample is necessary. The... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100203568 - Assay method for peptide specific t-cells: A method of assaying for peptide-specific T-cells comprises adding peptide to a fluid sample of fresh peripheral blood mononuclear cells, and detecting a cytokine such as interferon-γ produced by T-cells that have been pre-sensitised to the peptide. The assay method is quick and cheap and is expected to be useful... Agent: Baker Botts L.L.P.
20100203573 - Automated instrumentation and method for measurements of samples: One object of the invention is to provide instrumentation and a method for efficient and reliable assaying and measuring samples. The teachings include an automated self-contained instrument for assaying and measuring samples, wherein the samples are located on wells of sample plates, and the instrument comprises a plurality of units... Agent: Sughrue Mion, PLLC
20100203571 - Biochemical markers for acute pulmonary embolism: The present invention relates to a method of differentiating between a singular and a multiple lung embolism in a subject suspected to suffer from acute lung embolism comprising determining the amount of NT-proBNP in a sample of a subject suspected to suffer from acute lung embolism and comparing the amount... Agent: Roche Diagnostics Operations Inc.
20100203570 - Gene specifically expressed in postmitotic dopaminergic neuron precursor cells: A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network... Agent: Townsend And Townsend And Crew, LLP
20100203575 - In vitro beating heart model: The invention relates to a method for preparing a heart organotypic slice culture, comprising; a) providing a slice of heart, b) placing the slice of step a) on the upper surface of a semiporous support which is permeable to a culture medium, c) placing the support of step b) onto... Agent: Mcandrews Held & Malloy, Ltd
20100203574 - Method and apparatus for cultivating living cells: The invention relates to a method for cultivating living cells 6 in a liquid 5, wherein the cells 6 are introduced into at least one culture cavity 3, which is connected with at least one reservoir 2 for the liquid 5. The invention further relates to an apparatus 10 for... Agent: Joyce Von Natzmer Pequignot + Myers LLC
20100203572 - Method for carrying out and evaluating mix & measure assays for the measurement of reaction kinetics, concentrations and affinities of analytes in multiplex format: The invention relates to a method comprising the following steps: a) use of a support which has at least two different microparticle populations immobilized thereon; b) measuring the fluorescence of the support from step a) with an optical resolution 1, said resolution 1 permitting differentiation of microparticle singlets, doublets, triplets,... Agent: Londa, Bruce S. Norris Mclaughlin & Marcus, Pa
20100203569 - Method for evaluating risk in multiple sclerosis: The invention relates to methods and reagents for diagnosing and assessing the prognosis of multiple sclerosis. The present invention is based, in part, upon the discovery that anti-glycan antibodies are useful in evaluating the risk of whether clinically isolated syndrome (CIS) patients suggestive of Multiple sclerosis (MS) will have a... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100203579 - Method of measuring and comparing levels of substances in an individual's body: A method for measuring the homeostatic relationship between various substances in the body. The measured levels of substances in the body use the interrelationships of the various substances in order to establish guidelines for treating individuals.... Agent: Knoble, Yoshida & Dunleavy
20100203580 - Methods and apparatus for the location and concentration of polar analytes using an alternating electric field: A method is disclosed for effecting the concentration of a polar analyte in an alternating electric field. In the method, a relative translation of the polar analyte and an alternating electric field along a translation path is effected. A portion of the polar analyte is then trapped and concentrated in... Agent: Life Technologies Corporation C/o Intellevate
20100203577 - Methods of using gpr119 to identify compounds useful for increasing bone mass in an individual: The present invention relates to methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual. Agonists of GPR119 receptor are useful as therapeutic agents for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in... Agent: Fish & Richardson P.C.
20100203581 - Method for producing biofilm: For the purpose of forming a biofilm having amount and strength sufficient for the immobilization of a cell mass, the present invention provides a method for producing a biofilm, characterized in that it comprises co-culturing lactic acid bacteria belonging to Lactobacillus plantarum with yeast.... Agent: Birch Stewart Kolasch & Birch
20100203583 - Alteration and modulation of protein activity by varying post-translational modification: Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or... Agent: Traskbritt / Battelle Energy Alliance, LLC
20100203582 - Protein expression system involving mutated severe respiratory syndrome-associated coronavirus 3c-like protease: A mutated severe acute respiratory syndrome-associated coronavirus 3C-like protease and use thereof for cleaving a protein that includes a cleavage site recognizable by the mutated protease to yield a polypeptide fragment of interest.... Agent: Occhiuti Rohlicek & Tsao, LLP
20100203585 - Calcium-binding photoprotein, gene encoding the same, and use thereof: A protein according to the invention can be used to detect or measure calcium ions is provided. Further the protein is useful as a reporter protein or a luminescence marker. A polynucleotide according to the invention is also useful as a reporter gene.... Agent: Hogan Lovells US LLP
20100203584 - Host cells used for production of recombinant protein: It is an object of the present invention to provide host cells, which are able to proliferate in a serum free medium, which are able to synthesize and secrete a large amount of protein of interest, and which are able to produce a glycoprotein having a sugar chain structure. The... Agent: Greenblum & Bernstein, P.L.C
20100203586 - Modified 13-hydroperoxide lyases and uses thereof: Fatty acid 13-hydroperoxide lyase proteins which have been modified with respect to a previously described guava 13-hydroperoxide lyase and the nucleic acid sequences encoding these proteins. Also, recombinant nucleic acid molecules for expressing the modified 13-hydroperoxide lyases and methods of using such lyases in the field of organic synthesis.... Agent: Winston & Strawn LLP Patent Department
20100203588 - Polypeptides for inducing a protective immune response against staphylococcus aureus: The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO:... Agent: Merck
20100203587 - Use of dna gyrase inhibitors for in vitro polypeptide synthesis reactions: The present invention provides methods and compositions useful for in vitro polypeptide synthesis reactions. The methods involve the use of DNA gyrase inhibitors to prevent bacterial contamination in lysates used for in vitro production of polypeptides. The compositions include contamination-free cell lysates for in vitro protein synthesis reactions.... Agent: Townsend And Townsend And Crew, LLP
20100203589 - Method for obtaining active beta-ngf: The invention relates to a method for producing biologically active β-NGF from the proform proNGF. After expressing the proform of the β-NGF in a prokaryotic host cell, the recombinant protein is isolated in the form of insoluble inactive aggregates (inclusion bodies). After the solubilization thereof in a strong denaturing agent... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20100203590 - Antibodies that bind interleukin-4 receptor: The present invention relates to antibodies that bind to the IL-4 receptor, fragments, muteins, and derivatives of such antibodies, nucleic acids encoding such antibodies, fragments, muteins and derivatives, and methods of making and using such antibodies, fragments, muteins, derivatives and nucleic acids. Methods for treating medical conditions induced by interleukin-4... Agent: Immunex Corporation Law Department
20100203591 - Bioreactor, in particular for nmr spectroscopy: A description is given of a bioreactor (1), in particular for NMR spectroscopy, comprising a container (7) capable of containing a cell culture, a first inlet line (6) for the inward flow of a culture medium to the inside of the container and a second outlet line (9, 10) for... Agent: James C. Eaves Jr. Greenebaum Doll & Mcdonald PLLC
20100203592 - Method for production of glutathione or gamma-glutamylcysteine: The invention provides a process for producing glutathione or γ-glutamylcysteine by culturing in a medium a microorganism with a higher activity of a protein having an activity to transport intracellular glutathione to the outside of cells, and a higher activity of a protein involved in glutathione or γ-glutamylcysteine biosynthesis, compared... Agent: Leydig Voit & Mayer, Ltd
20100203593 - cip1 polypeptides and their uses: Described herein are novel gene sequences isolated from Trichoderma reesei. Two genes encoding proteins comprising a cellulose binding domain, one encoding an arabionfuranosidase and one encoding an acetylxylanesterase are described. The sequences, CIP1 and CIP2, contain a cellulose binding domain. These proteins are especially useful in the textile and detergent... Agent: Danisco US Inc. Attention: Legal Department
20100203594 - High-speed pcr using high-speed dna polymerase: [Means for Solving Problems] A method for practicing a high-speed PCR under a temperature change of 10° C./sec or more, characterized in that use is made of a heat-resistant DNA polymerase exhibiting a speed of synthesizing a deoxyribonucleic acid of 100 base/sec or higher, and a reagent kit for a... Agent: Kenyon & Kenyon LLP
20100203596 - Hybridization chamber for bioassay and hybridization method using the hybridization chamber: Provided is a hybridization chamber comprising two biochips disposed in one chamber such that surfaces of the biochips, to which biomolecules that are to be analyzed are respectively bonded, face each other, reducing the distance between probe biomolecules, thereby reducing the distance along which biomolecules move in the hybridization chamber.... Agent: Cantor Colburn, LLP
20100203597 - Recombinant reverse transcriptases: The present invention relates to a gene that encodes a hyperactive reverse transcriptase having DNA polymerase activity and substantially reduced RNase H activity, vectors containing the gene and host cells transformed with the invention. The present invention also includes a method of producing the hyperactive reverse transcriptase, producing cDNA from... Agent: Life Technologies Corporation C/o Intellevate
20100203595 - Thermal cycling apparatus and process: A thermal cycling apparatus 9 and process includes at least one reaction vessel 14 which is associated with a thermoelectric cooler 12 (TEC), such as a Peltier cell, and arranged to provide both heating and cooling of the reaction vessel. A first side of the TEC 12 is associated with... Agent: J. Bruce Hoofnagle
20100203598 - Microbial production of l-ascorbic acid: The present invention discloses an isolated polynucleotide molecule derived from a polynucleotide encoding a polypeptide having L-sorbosone dehydrogenase activity comprising a partial nucleotide sequence of at least 20 consecutive nucleotides of SEQ ID NO:1. The present invention further relates to a process for the production of L-ascorbic acid in high... Agent: Hoxie & Associates LLC
20100203599 - Mutant microorganisms having a high ability to produce putrescine and method for producing putrescine using the same: Provided are mutant microorganisms having the ability to produce a high concentration of putrescine wherein gene(s) involved in the putrescine degradation or utilization pathway is inactivated or deleted and a preparation method thereof. A method for producing putrescine in high yield by culturing the mutant microorganisms is also provided. The... Agent: Edwards Angell Palmer & Dodge LLP
20100203601 - Process for surface activation and/or devulcanization of sulfur-vulcanized rubber particles: Process for surface activation and/or devulcanization of sulfur-vulcanized rubber particles. In order to break the sulfur bridges and to reduce the sulfur, the rubber particles are treated in a biotechnological manner in a medium with mesophilic anaerobic and/or optionally anaerobic and/or microaerophilic bacteria and/or with one or more enzyme systems... Agent: Workman Nydegger 1000 Eagle Gate Tower
20100203602 - Materials and methods for efficient lactic acid production: The present invention provides derivatives of Escherichia coli constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100203603 - Microbial bioreaction process: A cis- or trans-stilbenoid of the general formula (1): in which each of R1, R2, R3, R4 and R5 is hydrogen or hydroxy, or a glycosylated or oligomeric form thereof, is produced by cultivating a micro-organism producing said stilbenoid, in a multi-phase system comprising at least an aqueous first phase... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20100203604 - Transformant capable of producing isopropanol: c
20100203606 - Isolation and characterization of novel clostridial species: A novel clostridia bacterial species (Clostridium ragsdalei, ATCC BAA-622/PTA-7826, “P11”) is provided. P11 is capable of synthesizing, from waste gases, products which are useful as biofuel. In particular, P11 can convert CO to ethanol. Thus, this novel bacterium transforms waste gases (e.g. syngas and refinery wastes) into useful products. P11... Agent: Fellers Snider Blankenship Bailey & Tippens
20100203605 - Method and apparatus for fractionating lignocellulose-based biomass: A method and apparatus for fractionating a lignocellulose-based biomass are provided. The method includes providing a lignocellulose-based biomass, extracting lignin from the biomass by adding a first solvent capable of dissolving the lignin, extracting xylose by adding a second solvent capable of dissolving hemicellulose to the biomass treated with the... Agent: Cantor Colburn, LLP
20100203607 - Processing biomass: Carbon-containing materials, such as biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) or coal are processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol.... Agent: Xyleco, Inc. Celia Leber
20100203608 - Method for the conversion of biomass from renewable raw materials in anaerobic fermenters: The invention relates to the field of biochemistry and relates to a method that is used in a biogas production plant. The object of the present invention is a method which realizes a shorter total retention time of the raw materials in the biogas plant and/or a higher quantity and/or... Agent: Greenblum & Bernstein, P.L.C
20100203609 - Photocatalytic hydrogen production and polypeptides capable of same: An isolated polypeptide comprising a hydrogen generating enzyme attached to a heterologous ferredoxin is disclosed, as well as polynucleotides encoding same, nucleic acid constructs capable of expressing same and cells expressing same. A method for generating hydrogen using the isolated polypeptide is also disclosed.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20100203610 - Methods of treating cell culture media for use in a bioreactor: The invention provides methods for treating cell culture media for use in a bioreactor using ultraviolet C (UVC) light and filtration.... Agent: Amgen Inc.
20100203611 - Novel nuclear translocation peptide: The present invention provides a peptide comprising amino acid sequences R I, F I and R I G C and containing 25 or fewer amino acid residues, and capable of transporting a functional molecule into a cell, and also into a nucleus, more efficiently than a previous PTD.... Agent: Wenderoth, Lind & Ponack, L.L.P.
20100203612 - Specific peptide binding to glypican-3: A specific targeting peptide binding to glypican-3 can specifically binds to glypican-3 overexpressed in carcinoma cells and includes an amino acid sequence represented by SEQ ID No. 1 or some thereof. Glypican-3 is overexpressed in malignant tumors including hepatocellular carcinoma, melanoma, germ cell tumor, etc., and may be targeted in... Agent: Workman Nydegger 1000 Eagle Gate Tower
20100203613 - Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition: Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator
20100203614 - Fatty aldehyde reductase: This disclosure relates to the polynucleotide sequences of SEQ ID NO: 1 and SEQ ID NO: 4, and to the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 3, and to novel fatty aldehyde reductase enzymes provided by the same.... Agent: Utah State University Technology Commercialization Office
20100203615 - Polypeptides having endoglucanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes, Inc.
20100203616 - Refolded recombinant alpha secretase crystals and methods for preparing and using the same: The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the... Agent: Merck Patent Department (k-6-1, 1990)
20100203617 - Use of saccharomyces cerevisiae erg4 mutants for expressing mammalian glucose transporters: The invention relates to yeast strains in which a human GLUT4 transport or a human GLUT1 transporter can be functionally expressed and to particular GLUT4 transport proteins which can be functionally expressed particularly readily in yeast strains.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC
20100203618 - Process for the cultivation of micro-algae: Process for the cultivation of micro-algae comprising the planting of an algal strain in an aqueous environment and the growth process, under solar irradiation, by continuously feeding a gaseous stream essentially consisting of carbon dioxide and a stream of nutrients based on nitrogen, consisting of wastewater from industrial plants, coming... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100203619 - Co2 absorption solution: Disclosed is a formulation for the absorption of CO2, which comprises water, at least one CO2 absorption compound and a carbonic anhydrase as an activator to enhance the absorption capacity of the CO2 absorption compound. The invention also concerns the use of carbonic anhydrase, in a CO2 absorption solution to... Agent: Knobbe Martens Olson & Bear LLP
20100203620 - Apparatus for culturing eucaryotic and/or procaryotic cells: An apparatus for culturing eucaryotic and/or procaryotic cells comprising an incubator (10), operating means (20) to generate predetermined environmental conditions within the incubator (10), and one or more control devices (30) to control the operating means (20) depending on the desired environmental conditions; apparatus (1) further comprises an electromagnetic-insulation chamber... Agent: Pearne & Gordon LLP
20100203621 - Biosensor: A biosensor has the following elements: a diaphragm having a through-hole; a frame supporting the diaphragm and having a cavity; and pillars formed on the side of inner wall surface of the frame and on the surface of the diaphragm. This structure can suppress the occurrence of bubbles in the... Agent: Ratnerprestia
20100203622 - Method for determining the phenotype of cells: The present invention provides a system, a device, and a kit for comparing the phenotypic state of a first unknown sample material with a sample material of a known phenotypic state. The present invention also provides a method of using the system, device and kit.... Agent: Philip S. Johnson Johnson & Johnson
20100203623 - Substrate imprinted universal sensors and sensors having nano-tunneling effect: A universal sensor fabrication approach, molecular substrate imprinting technique, which utilizes the interaction between molecular building blocks and the surface of a transducer to develop specific molecular recognition cavities has been established. Integration of molecular recognition cavities with the surface of a nanoscale transducer will result in a nano-tunneling effect... Agent: Zeman-mullen Law Firm PLLC
20100203624 - Three dimensional disposable bioreactor: A bioreactor including a support, a container, means to secure the container on the support and nutrients and cell in the container. The container has top and bottom walls joined to form a chamber having a portion of the top and bottom walls joined by side walls; and end walls... Agent: Ge Healthcare Bio-sciences Corp. Patent Department
20100203625 - System and method for processing biomass: According to one embodiment of the invention, a system for processing biomass comprises a chamber, a biomass input device, a fluid input device, and a retrieval device. The chamber is defined by at least a bottom, at least one wall, and a cover supported by the at least one wall.... Agent: Conley Rose, P.C. David A. Rose
20100203626 - Solid state fermentation in modified zymotis packed bed bioreactor: The embodiments herein provide an improved Zymotis solid-state bioreactor and its operation for cultivation of microorganisms aseptically. In one embodiment, a bioreactor has two compartments containing three cooling plates. These plates have internal baffles instead of cooling tubes. The bioreactor has temperature sensors are loaded at different heights of the... Agent: Choobin & Choobin Consultancy L.l.c Barry Choobin
20100203627 - Long-term in vivo transgene expression: Efficient and prolonged hCFTR expression is one of the major obstacles for cystic fibrosis lung therapy. hCFTR mRNA expression levels depend on eukaryotic expression cassette components, prokaryotic backbone elements, and the gene transfer method may also influence transcriptional silencing mechanisms. A codon-optimized and CpG-reduced human CFTR gene (CO-CFTR) was made.... Agent: Banner & Witcoff, Ltd.
20100203629 - Cytoplasmic bkca channel intron-containing mrnas contribute to the intrinsic excitability of hippocampal neurons: The invention relates to a method of modulating neuronal function by modulating the cytoplasmic level in a neuron of an intron-containing mRNA. The methods are useful in diagnostic, research and therapeutic applications.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20100203628 - Novel modified galectin 9 proteins and use thereof: It is suggested that recombinant galectin 9 (rGal 9), produced in host Escherichia coli, exhibits an immune system-mediated action and a direct action on tumor cells (i.e., activity of inducing the intercellular adhesion and apoptosis of the tumor cells), thereby potent in inducing the inhibition of cancer metastasis and reduction.... Agent: Wenderoth, Lind & Ponack, L.L.P.
20100203631 - Antibodies to alpha-synuclein: The invention provides methods for detecting alpha-synuclein. The invention also identifies preferred epitopes of alpha synuclein for use in such detection, and provides antibodies specifically binding to such epitopes.... Agent: Townsend And Townsend And Crew LLP
20100203630 - In vitro human b lymphopoiesis culture system: The present disclosure relates to systems, methods and compositions for the generation of antibody-producing B cells in vitro. Some embodiments are related to an in vitro system for generating antibody-producing B cells from hematopoietic stem/progenitor cells (HSPCs).... Agent: Knobbe Martens Olson & Bear LLP
20100203632 - Methods for controlling stem cell differentiation: Disclosed herein are methods for controlling stem cell differentiation through the introduction of transgenes having Xic, Tsix, Xite, or Xic flanking region sequences to block differentiation and the removal of the transgenes to allow differentiation. Also disclosed are small RNA molecules and methods for using the small RNA molecules to... Agent: Clark & Elbing LLP
20100203633 - Culture system for rapid expansion of human embryonic stem cells: This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described here, the role of feeder cells is replaced by components added to... Agent: Geron Corporation Attn. David J. Earp
20100203635 - Composition and method for enabling proliferation of pluripotent human stem cells: Compositions and processes for culturing human stem cells in vitro in an undifferentiated state are disclosed. In this regard, human embryonic stem cells proliferated and maintained their pluripotency when cultured on plates coated with recombinant laminin-10 (laminin-511).... Agent: Fay Sharpe LLP
20100203634 - Inhibition of stem cell differentiation, enhancement of proliferation and selective induction of apoptosis by wnt factors: The invention relates to a method for at least in part inhibiting differentiation of stem cells in a population of mammalian cells comprising up-regulating a Wnt-signaling pathway to a differentiation-inhibiting level in the population of cells. The invention increases at the same time the number of stem cells in a... Agent: Traskbritt, P.C.
20100203636 - Method for isolating islets of langerhans: Islets of Langerhans from a pancreas are isolated by exposing the pancreas to a very high-glucose (approximately 60 mM to 900 mM) solution to cause shrinking and accommodation of the acinar cells to the solution. Thereafter the very high-glucose solution is replaced with a low or zero-glucose solution to thereby... Agent: Floyd B. Carothers Carothers And Carothers
20100203637 - Fluorescent cell markers: The preparation and use of fluorescent cell markers of the structure F—S1-S2-L is described where F is a fluorophore, S1-S2 is a spacer linking F to L, and L is a diacyl lipid.... Agent: Nixon & Vanderhye, PC
20100203638 - Method of producing high-density cultured tissue and high-density cultured tissue: It is intended to provide a method comprising providing a mesh member and a liquid flow controlling member in a channel, in which a cell culture liquid containing an extracellular matrix component and animal cells of one or more types are cultured under circulation, so that the liquid flow-controlling member... Agent: Novak, Druce & Quigg LLP
20100203639 - Compositions and methods for plant genetic modification: Mixed duplex oligonucleotides (MDON) are used to effect site-specific genetic alterations in a target DNA sequence of a plant. The MDON are introduced by electroporation into microspores. Thereafter, plants having a desired genetic alteration are produced by germinating the microspores.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100203640 - Antigen presenting cells: The present invention relates to a method for inducing specific long-lasting robust immunological tolerance towards at least one polypeptide derived from at least one allergen by transplanting a hematopoietic (stem) cell which is produced to display the said at least one polypeptide derived from at least one allergen.... Agent: Chalker Flores, LLP
20100203641 - Methods and compositions for expressing negative-sense viral rna in canine cells: The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make... Agent: Medimmune, LLC Patrick Scott Alban08/05/2010 > patent applications in patent subcategories.
20100196871 - Apparatus and methods for culturing and/or transporting cellular structures: An apparatus for culturing and/or transporting embryos, oocytes or other cellular structures, comprising a housing (12) having a gas space (28) and a media space (18) for a liquid medium separated from one another by a barrier (16) having one or more gas permeable regions to allow gas diffusion from... Agent: Goodwin Procter LLP Attn: Patent Administrator
20100196870 - Sterilized xenograft tissue: The invention provides an article of manufacture comprising a substantially non-immunogenic xenograft for implantation into humans. The invention also provides methods for preparing a xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol;... Agent: Gunn, Lee & Cave, P.C.
20100196872 - Semen extender composition and methods for manufacturing and using: A semen extender composition is provided. The semen extender composition includes a sperm cell protecting amount of phospholipid, an effective amount of surfactant to reduce ice crystal formation during freezing of the composition; a carbohydrate, and a biological buffer to provide a semen extender use solution having a pH of... Agent: Merchant & Gould PC
20100196873 - Systems and methods for cryopreservation of cells: A fluid sample vessel includes inlet and vent tube fittings formed at one end of a container with an opposite open end closed by a needle septum. A support cap is removably engaged to the container to support the container and protect terminal ends of inlet and vent tubular branches... Agent: Maginot, Moore & Beck, LLP Chase Tower
20100196874 - method of drug design: The description discloses that amiloride-like compounds inhibit enterovirus RNA replication by interaction with RNA dependent RNA polymerase (RdRP). The description discloses in silico and in vitro methods of screening for inhibitors of RdRP activity, amiloride-resistant enterovirus variants and amiloride-like compounds.... Agent: Scully, Scott, Murphy & Presser, P.C.
20100196878 - Dual-recognition immunoassay for the detection of antibodies: The invention relates to a dual-recognition immunoassay for the detection of antibodies specific to a target antigen in a sample which comprises contacting said target antigen with a sample suspected of containing said antibodies specific to said target antigen under conditions allowing the formation of an antigen-antibody complex; adding a... Agent: Moore & Van Allen PLLC
20100196875 - Human erythrovirus: Nucleic acid molecules derived from sequences of novel human parvovirus B19 variant genomes are provided. Also provided are assays and kits comprising the nucleic acid molecules.... Agent: Womble Carlyle Sandridge & Rice, PLLC
20100196877 - Method of detection of microorganisms with enhanced bacteriophage amplification: A method of determining the presence or absence of a target microorganism in a sample to be tested, the method comprising: combining with the sample an amount of bacteriophage capable of attaching to the target microorganism to create a bacteriophage exposed sample, and a substance which enhances bacteriophage amplification or... Agent: Patton Boggs LLP
20100196876 - Methods and reagents for genotyping hcv: The present invention is directed to methods and reagents for determining the genotype of a hepatitis C virus (HCV) species present in a test sample. The invention more particularly relates to mixtures of degenerate amplification and sequencing primers, and methods of using such primers, that are complementary to a plurality... Agent: Siemens Corporation Intellectual Property Department
20100196906 - Accelerated progression relapse test: Disclosed is an accelerated progression relapse test for use in the prognosis of disease states. According to the test disclosed herein, it can be determined whether a patient would benefit from treatment for a disease state or whether the patient's prognosis would not have a high probability of benefit with... Agent: K&l Gates LLP
20100196905 - Adult stem cell assays: Provided are methods for quantifying adult stem cells in a test sample, methods of quantifying adult stem cells in a patient, and methods for quantifying differentiated cells in a test sample. Also provided are kits for quantifying adult stem cells or differentiated cells in a sample.... Agent: Finnegan/kci
20100196904 - Ambient temperature stable kits for molecular diagnostics: A method for processing DNA polymerase and/or dNTPs for use in an amplification procedure, includes providing a solution mixture, the solution mixture including a DNA polymerase and/or dNTPs, a buffer solution and at least one stabilizing agent and hydration reducing the solution mixture. The solution mixture is hydration reduced at... Agent: Morgan, Lewis & Bockius LLP (sf)
20100196883 - Androgen-regulated genes and uses for diagnosis, prognosis and treatment of prostate neoplastic conditions: The invention provides a method for diagnosing or predicting susceptibility to a prostate neoplastic condition in an individual. The method involves (a) determining a level of RDC1 in a sample from the individual, and (b) comparing the level of RDC1 in the sample to a reference level of RDC1, wherein... Agent: Mcdermott, Will & Emery
20100196911 - Automated identification of genetic test result duplication: The present invention relates to a method and system for determining whether an ordered genetic test will duplicate at least one existing genetic test result. The method includes receiving an ordered genetic test that is for a particular genetic sequence or variant thereof for an individual. The method further includes... Agent: Shook, Hardy & Bacon L.L.P. (cerner Corporation)
20100196917 - Cell analysis apparatus and cell analysis method: A cell analysis apparatus that can accurately distinguish between an aggregating cell and a non-aggregating cell is provided. The cell analysis apparatus (10) includes: an optical detection section (3) for flowing a measurement sample obtained from a biological sample and a pigment into a flow cell (51), irradiating the measurement... Agent: Brinks Hofer Gilson & Lione
20100196887 - Compositions and methods for multiplex analysis of polynucleotides: Provided herein are compositions and methods for the multiplex analysis and/or detection of polynucleotides having one or more distinguishable target sequences. The methods employ signal-quencher probe pairs having specific relative differential thermal melting temperatures that permit the detection of one or more target sequences on one or more polynucleotides.... Agent: Life Technologies Corporation C/o Intellevate
20100196903 - Compositions and methods to detect tmprss2/erg transcript variants in prostate cancer: Compositions and methods for detecting TMPRSS2/ERG transcript variants in prostate cancer are provided. The compositions and methods have utility in prostate cancer diagnosis.... Agent: Gen Probe Incorporated
20100196880 - Compositions and multiplex assays for measuring biological mediators of physiological health: Multiplex assays are provided including panels of probes for development of multiplex assays capable of simultaneously measuring multiple biologically-relevant proteins using very small quantities of biological samples to rapidly assess the health status of animals, especially companion animals, as well as to formulate nutritional regimens for improving the health status... Agent: Wendell Ray Guffey Nestle Purina Petcare Global Resources, Inc.
20100196898 - Disease-associated genetic variations and methods for obtaining and using same: The invention provides a comprehensive, rapid, unbiased, and accurate method for identifying and/or discovering disease-associated genetic variations, e.g., disease-associated variations. The present invention further provides novel disease-associated genetic variations for use as genetic markers of disease, e.g., cancer. The invention further provides methods for assessing an individual's risk for developing... Agent: Edwards Angell Palmer & Dodge LLP
20100196879 - Dna diagnostic screening for turner syndrome and sex chromosome disorders: The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of Turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the X and Y chromosomes.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20100196916 - Drug screening using islet cells and islet cell progenitors from human embryonic stem cells: This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High quality populations of islet cells can be produced in commercial quantities for use in research,... Agent: Geron Corporation Attn. David J. Earp
20100196882 - Galectin-3 nssnp marker for cancer: A diagnostic biomarker including a mechanism for determining a patient's propensity to develop cancer. A diagnostic kit for determining a patient's propensity to develop cancer. A method of predicting both a patient's and a population's propensity to develop cancer, by detecting the presence of an H64 and/or P98 allele of... Agent: Kohn & Associates, PLLC
20100196889 - Gene expression profiling for identification, monitoring and treatment of colorectal cancer: A method is provided in various embodiments for determining a profile data set for a subject with colorectal cancer or conditions related to colorectal cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100196888 - Genotyping using multiple variant-specific primer pools: This invention relates to the identification of variants of an organism using variant-specific oligonucleotide primer pools to specifically hybridize to those polynucleotides in an sample comprising a plurality of polynucleotides that contain a target sequence that is unambiguously identifiable with a particular variant of the organism.... Agent: Squire, Sanders & Dempsey L.L.P.
20100196891 - Ibc-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer: This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of identifying and manufacturing therapeutic compounds, and methods of treating patients with invasive and metastatic breast cancer or degenerative neural conditions.... Agent: Fish & Richardson P.C.
20100196907 - Markers to predict and monitor response to aurora kinase b inhibitor therapy: The present invention relates to identifying the presence or absence of one or more copy number gains in the ABCB1 gene, the ABCB4 gene or combinations thereof, identifying patients eligible to receive Aurora kinase inhibitor therapy, either as monotherapy or as part of combination therapy, and monitoring patients' response to... Agent: Paul D. Yasger Abbott Laboratories
20100196896 - Method and a kit for identifying a human who has the predisposition for increased consumption of carbohydrates and method for managing the named human's dietary intake of nutritional energy: A method and a kit for determining the human with genetic predisposition to increased consumption of carbohydrates and to develop metabolic, psychiatric or neurological disease or disorder, or obesity. The invention pertains to the detection of a human's ADRA2A genotype, and if there is detected the homozygous nucleotide G at... Agent: Reed Smith LLP
20100196897 - Method and device for non-invasive prenatal diagnosis: Method for non-invasive prenatal diagnosis comprising the following steps: a. obtain a sample of an organic fluid having a high probability of containing foetal cells from a pregnant woman; b. enrich said sample of organic fluid in at least one population of cells comprising at least one type of foetal... Agent: Marshall, Gerstein & Borun LLP
20100196895 - Method for determination of onset risk of glaucoma: A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100196893 - Method for genotyping dna tandem repeat sequences: The present invention provides methods for determining the number of tandem repeat units in a region of double stranded DNA based on the use of RecA-like recombinase protein and oligonucleotide ligation. The methods of the present invention provide RecA coated, specific DNA oligonucleotide probes (RecA filaments) for homology searching in... Agent: The Mccallum Law Firm, P. C.
20100196901 - Method for obtaining information on biological rhythm by using hair: To provide a simple and low-invasive method for obtaining information on a biorhythm of an individual organism. Provided is a method for obtaining information on a biorhythm of an individual organism based on variations over time in an expression level of a clock gene in a hair follicle cell of... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20100196900 - Method of detecting canine exercise-induced collapse: The present invention relates to diagnosing Canine Exercise-Induced Collapse (EIC).... Agent: Viksnins Harris & Padys Pllp
20100196915 - Method of detecting oncogenesis of hematopoietic cells: Disclosed in a method of detecting cancer using IL-27 receptors. IL27R is a cytokine receptor identified as a novel oncogene from an acute myeloid leukemia patient. It induces cancer-like properties when expressed in cells and can activate a protein that causes various myeloid cell disorders. The data show cytokine receptors... Agent: Smith Hopen, Pa
20100196892 - Methods and systems for molecular fingerprinting: This invention relates in general to a method for molecular fingerprinting. The method can be used for forensic identification (e.g. DNA fingerprinting, especially by VNTR), bacterial typing, and human/animal pathogen diagnosis. More particularly, molecules such as polynucleotides (e.g. DNA) can be assessed or sorted by size in a microfabricated device... Agent: Townsend And Townsend And Crew, LLP
20100196910 - Methods of generating human cardiac cells and tissues and uses thereof: A method of generating cells predominantly displaying at least one characteristic associated with a cardiac phenotype is disclosed. The method comprises (a) partially dispersing a confluent cultured population of human stem cells, thereby generating a cell population including cell aggregates; (b) subjecting the cell aggregates to culturing conditions suitable for... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20100196885 - Methods of validating candidate compounds for use in treating copd and other diseases: The present invention relates to methods of diagnosing and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, refractory asthma, and other related diseases. Examples of such methods include... Agent: Bryan Cave LLP
20100196913 - Mutant aox1 promoters: A mutant Pichia pastoris alcohol oxidase 1 (AOX1) promoter of the wild type Pichia pastoris AOX1 promoter (SEQ ID No. 1) comprising at least one mutation selected from the group consisting of: a) a transcription factor binding site (TFBS), b) nucleotides 170 to 235 (−784 to −719), nucleotides 170 to... Agent: Chalker Flores, LLP
20100196884 - Nucleic acid preparation: The present invention is directed to methods, devices and computer programs for preparing nucleic acids from a template nucleic acid by subjecting a sample to thermocycles. After a first number of thermocycles, a partial amount of the reaction mixture is being subjected to a second number of thermocycles. This two... Agent: Roche Molecular Systems, Inc. Patent Law Department
20100196909 - Parp-based cytochemical and histochemical detection methods and kits therefore: The present invention relates to new cytochemical and histochemical detection methods based on the enzymatic activity of poly-ADP-ribose-polymerases (PARP). In particular, the present invention provides methods and systems for cytochemical or histochemical detection of a molecule of interest based on detecting poly-ADP-ribose (PAR). Further, the present invention provides methods for... Agent: Whitham, Curtis & Christofferson & Cook, P.C.
20100196912 - Polyelectrolyte-coated size-exclusion ion-exchange particles: A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided.... Agent: Life Technologies Corporation C/o Intellevate
20100196890 - Primers for melting analysis: Methods and kits are provided for nucleic acid analysis. In an illustrative method a target nucleic acid is amplified using a first primer and a second primer, wherein the first primer comprises a probe element specific for a locus of the target nucleic acid and a template-specific primer region, and... Agent: Ice Miller LLP
20100196894 - Procedure for the detection of paratuberculosis: The present invention relates to a procedure for the specific and sensitive detection of Mycobacterium avium ssp. paratuberculosis (MAP) in fecal, tissue and organ samples using a real-time PCR procedure.... Agent: Clark & Brody
20100196902 - Prostate cancer biomarkers: Disclosed are biomarkers, at least, useful for the diagnosis and/or prognosis of cancer and for making treatment decisions in cancer, for example prostate cancer.... Agent: Klarquist Sparkman, LLP
20100196914 - Rare cell detection using flat-panel imager and chemiluminescent or radioisotopic tags: Disclosed is a method using a large area flat panel imager which is specifically adapted for rare cell detection methods. The method generally includes an imager having a sample receiving surface which can provide a digital or electronic image of a sample deposited on the surface. The method also includes... Agent: Fay Sharpe LLP / Xerox - Parc
20100196881 - Reverse restriction fragment length polymorphism assay and uses thereof: The present invention presents a Reverse Restriction Fragment Length Polymorphism (RRFLP) method for the detection of the presence of an informative restriction enzyme site in a nucleotide sequence. The method includes digesting a sample with the informative restriction enzyme; performing polymerase chain reaction (PCR) on the digested sample with an... Agent: Mueting, Raasch & Gebhardt, P.A.
20100196886 - Screening, diagnosing, treating and prognosis of pathophysiologic status by rna regulation: A relationship between cancer and ribonucleic acid (RNA) regulation is described by determining intracellular levels of niRN A regulators. Generally, mRNA levels are decreased in cancer cells that may be a reflection of either reduced mRNA expression and/or increased mRNA degradation. miRNAs are identified that hybridize to an mRNA that... Agent: Peter G Carroll Medlen & Carroll
20100196908 - Systems and methods for detecting a signal and applying thermal energy to a signal transmission element: A signal detection system configured for detecting a signal emitted by the contents of a reaction receptacle is also configured to apply thermal energy to a portion of the reaction receptacle to affect a reaction occurring within the reaction receptacle. More particularly, a system for detecting electromagnetic radiation emitted by... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100196899 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: The Invention Science Fund Clarence T. Tegreene
20100196918 - Analyte sensors, methods for preparing and using such sensors, and methods of detecting analyte activity: Embodiments of the present disclosure provide for analyte sensors, methods for producing and using the analyte sensors, methods of detecting and/or measuring analyte activity, methods for characterizing analyte cellular activity, methods of detecting pH change in a system, method of controlling the concentration of an analyte in a system, fusion... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP
20100196922 - Fluorescent metal ion indicators with large stokes shifts: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the... Agent: Life Technologies Corporation C/o Intellevate
20100196924 - Method for diagnosing tumors: The present invention describes a method for diagnosing tumors of the reproductive organs which is characterised by determination of the afamin content in a sample of a body fluid or in a tissue sample, wherein a tumour is diagnosed if the afamin content in the sample is decreased compared to... Agent: Fulbright & Jaworski L.L.P.
20100196921 - Method for predicting the outcome of a critically ill patient: The present invention relates to a method for predicting the outcome of a critically ill patient, said method comprising measuring the concentration of Chromogranin A or a fragment thereof in a biological sample obtained from said patient.... Agent: Mcandrews Held & Malloy, Ltd
20100196920 - Nanoscopic biomolecular absorption spectroscopy enabled by single nanoparticle plasmon resonance energy transfer: The disclosure provides methods and compositions useful for measuring a target analyte in a sample with nanoparticle plasmon resonance. In particular the disclosure provides methods and compositions for measuring a target analyte comprising plasmon resonance energy transfer.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP
20100196919 - Peptides, antibodies and fragments thereof for the treatment and diagnostic of celiac disease: The present invention discloses a peptide having an amino acid sequence comprising an epitope recognized by Igs of patients with active celiac disease and not recognized by Igs of patients on gluten-free diet, antibodies directed against this peptide and methods for diagnosing the celiac disease in a subject, or to... Agent: Lucas & Mercanti, LLP
20100196923 - Pluripotent adult stem cells: Disclosed herein are pluripotent adult stem cells and methods of use thereof. The cells are found in, or collected from, an adult tissue or fluid. In some embodiments, the cells are c-kit positive and SSEA-4 positive, and can he differentiated into multiple tissue types, e.g., adipogenic, osteogenic, myogenic, endothelial, neurogenic... Agent: Myers Bigel Sibley & Sajovec
20100196925 - Methods for screening cells and antibodies: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20100196930 - Cell based assays for the triglyceride synthesis pathway: A method for identifying a compound which modulates the activity of acyl-coA: diacylglycerol acyltransferase comprises the steps of contacting a stable isotope labeled fatty acid with cells in either presence or absence of the compound, extracting the cells with isopropyl alcohol, and determining the level of a stable isotope labeled... Agent: Philip S. Johnson Johnson & Johnson
20100196928 - Gene specific to cancer and diagnosis kit using the same: The present invention provides a new additional identification of a gene related to cancer expression and a diagnostic kit using the same.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik
20100196929 - Stabilisation of the phenotypic properties of isolated primary cells: The invention provides a method for stabilisation of phenotypic properties of isolated primary cells comprising modulating at least two epigenetic modifications in said cells.... Agent: Knobbe Martens Olson & Bear LLP
20100196931 - Determination of responders to chemotherapy: The present invention relates to a method of determining whether a biological sample comprising human lung cancer cells is sensitive to a combination of an epidermal growth factor receptor inhibitor and a chemotherapeutic agent by determining the overexpression of a phosphorylated AKT protein and/or a phosphorylated MAPK protein in the... Agent: Hoffmann-la Roche Inc. Patent Law Department
20100196932 - Yeast reporter system: Cell-based screens for compounds that inhibit the accumulation of amyloids are described. For example, the herein described screens may be used to assay the formation, or inhibition, of pre-amyloid or amyloid aggregates and/or oligomers. Agents have been identified that interfere with, or inhibit, the oligomerization of the major component of... Agent: Jane Massey Licata, Esq. Licata & Tyrrell P.C.
20100196926 - Combined method and kit for the sequential measurement of (1) the enzymatically active fraction and (2) the total amount of an enzyme: The present invention is related to a combined method and kit (or device) for the sequential measurement of the enzymatically active fraction and the total amount of an enzyme [(such as myeloperoxidase (MPO)] in a sample, and that find improved applications in veterinary and human health fields.... Agent: Fitch Even Tabin & Flannery
20100196927 - Method of determining functional deficiencies in the complement system: The present invention relates to a method of in vitro determining functional deficiencies in the lectin pathway of the complement system, the method comprises the steps of (a) diluting a mammalian sample of body fluid with a diluent comprising one or more inhibitors of the activation of the classical and... Agent: Merchant & Gould PC
20100196936 - Method and kit for detecting cancer: A method for detecting cancer is disclosed. The method includes the steps of: (1) obtaining a test sample of body fluid from a subject; (2) measuring a calsyntenin-1 (CLSTN-1) level in the test sample of body fluid in vitro; and determining if the CLSTN-1 level in the test sample of... Agent: Edwards Angell Palmer & Dodge LLP
20100196934 - Prion assay: The invention relates to an assay method for detecting the presence of PrPSc using at least one sequence-specific protease for a substantially complete digestion of the proteins in a sample, leaving the octarepeat region in both PrPSc and PrPC intact, leaving the protease-resistant core of PrPSc intact and remain connected... Agent: Novartis Vaccines And Diagnostics Inc.
20100196933 - Recombinant polypeptides for diagnosing infection with trypanosoma cruzi: Recombinant polypeptides are disclosed that are useful for diagnosing American trypanosomiasis, or Chagas disease, a disease caused by the infectious agent Trypanosoma cruzi. Preferably, DNA sequences encoding the recombinant proteins are placed in plasmid vectors to be expressed in an organism.... Agent: Novak, Druce & Quigg LLP
20100196935 - Treating pre-eclempsia and cardiovascular diseases: This document relates to methods and materials involved in identifying, predicting, and treating pre-eclampsia or a cardiovascular disease (e.g., atherosclerosis) in mammals. For example, methods and materials involved in using serum levels of HtrA polypeptides to identify pre-eclampsia or a cardiovascular disease, using HTRA polymorphisms to predict pre-eclampsia or a... Agent: Fish & Richardson P.C.
20100196937 - Cascade enzyme-linked immunosorbent assay: The present invention relates to a cascade enzyme-linked immunosorbent assay, more precisely a cascade enzyme-linked immunosorbent assay using magnetic microparticles (MMPs) immobilized with the target antigen specific primary antibody and silica nanoparticles (SPs) immobilized with a cascade reaction initiator and the antigen-specific secondary antibody. When the method of the present... Agent: Greenlee Winner And Sullivan P C
20100196938 - Immunoassay for venom detection including noninvasive sample collection: Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an... Agent: Greenlee Winner And Sullivan P C
20100196939 - Diagnosis of conditions associated with decreased arginine bioavailability: The invention features methods and compositions for diagnosis, including prognosis, of conditions associated with decreased arginine bioavailability (which can result from dysregulated arginine metabolism, e.g., due to increased arginase activity) by assessing in a sample from a subject the ratio of arginine to one or more, usually two or more,... Agent: Bozicevic, Field & Francis LLP
20100196940 - Methods related to cell surface glycosylation: The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.... Agent: Choate, Hall & Stewart LLP
20100196941 - Multi-analyte analysis of saliva biomarkers as predictors of periodontal and pre-implant disease: The present invention relates to methods of measuring biomarkers to determine the probability of a periodontal and/or peri-implant disease. More specifically, the invention provides a panel of biomarkers that, when used in combination, can allow determinniation of the probability of a periodontal and/or peri-implant disease state with extremely high accuracy.... Agent: Marshall, Gerstein & Borun LLP
20100196942 - Biomarkers of liver injury: Novel, sensitive and specific markers for diagnostics and monitoring of liver injuries, including, but not limited to ischemic liver damage, are provided. This includes identification several enzymes of arginine/urea/nitric oxide cycle, sulfuration enzymes and spectrin breakdown related products, among others.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100196943 - Identification and characterization of racemases, definition of protein signatures, and a test for detecting d-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase: This invention relates to the identification and characterization of racemases and definition of protein signatures of these racemases. More particularly, this invention relates to the identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20100196950 - Automated seed sampler and methods of sampling, testing and bulking seeds: An automated seed sampler includes a sampling station; a sampler for removing material from a seed in the sampling station; a seed conveyer for conveying the seed from the sampling station to a compartment in a seed tray; and a conveyor for conveying the material removed from the seed to... Agent: Harness, Dickey & Pierce, P.L.C
20100196946 - Device and method for conditioning biological cells: A conditioning device (100) for biological cells includes a support (10), adapted to support at least one biological cell (1) in a supporting zone (11), and a contact device (20), adapted to support at least one conditioning sample (3) and to displace the at least one conditioning sample (3) relative... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
20100196945 - Device and method for determining the erythrocyte sedimentation rate in a blood sample: The invention discloses a blood analyzing device (100) comprising a holder (110) arranged for carrying a container (10) having a cuvette (20) containing a blood sample (30). The container (10) is positioned in the holder (110) so that a longitudinal axis (60) of the cuvette (20) is angled relative a... Agent: Birch Stewart Kolasch & Birch
20100196944 - Method of bioassaying yokukansan: To find out an in-vitro bioassay system capable of ensuring qualities of yokukansan to a higher degree, it is intended to provide a method of bioassaying yokukansan characterized by comprising adding a yokukansan-containing test sample to astroglial cells to be cultivated under the condition of thiamine deficiency, and then determining... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100196948 - Method of screening baff suppressor or inhibitor: A method of screening a novel BAFF suppressor or inhibitor. More specifically speaking, a method which comprises adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell to thereby induce the production of BAFF by the cell; a method of screening a substance capable... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20100196947 - Polyelectrolyte multilayer films at liquid-liquid interfaces: The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid-liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at... Agent: Quarles & Brady LLP
20100196949 - Sample well strip: A multiple cuvette strip comprises a plurality of wells and a reversible interlocking device. The well strips can be reversibly interlocked to other well strips to form a sample holder system. One embodiment of a well strip comprises a flange and a slot to form a reversible interlocking device.... Agent: Burns & Levinson, LLP
20100196951 - Antitoxin destabilization technology: Disclosed are methods for purifying toxin proteins which avoid denaturation and renaturation procedures.... Agent: Patent Docket Administrator Lowenstein Sandler PC
20100196952 - Method for preparative in vitro protein biosynthesis: The invention relates to a method for preparative in vitro protein synthesis of an expression product in a cell-free transcription/translation system, comprising the following steps: a) in a reaction vessel, a reaction solution is prepared, comprising the following synthesis substances: components of the transcription/translation apparatus for a defined expression product,... Agent: Mayer & Williams PC
20100196959 - Alleles of the opca gene from coryneform bacteria: The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 188.8.131.52), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.... Agent: Smith, Gambrell & Russell
20100196953 - Cleavage of precursors of insulins by a variant of trypsin: The present invention relates to the production of a variant of recombinant trypsin with increased substrate specificity for arginine versus lysine in non-animal host organisms. Moreover, the present invention relates to a variant of recombinant trypsin and their production. Also provided are use of recombinant porcine pancreatic trypsin variants for... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC
20100196957 - Cloning and characterization of 5' flanking regions of a human aggrecanase-1 gene: The present invention relates to an isolated polynucleotide molecule comprising an Agg-1 promoter gene and methods of using the same. The invention also provides a method for producing an expression product encoded by a nucleic acid through use of an Agg-1 promoter.... Agent: Novartis Corporate Intellectual Property
20100196954 - Modified endoglucanase ii and methods of use: Described herein is a modified EGII cellulase having the amino acid sequence shown in SEQ ID NO:1, compositions comprising the modified EGII and methods of use.... Agent: Danisco US Inc. Attention: Legal Department
20100196956 - Novel constitutive strong promoter and use thereof: Disclosed herein are an aldolase gene promoter and the use thereof, more particularly, disclosed are a promoter of aldolase gene derived from Lactobacillus casei, having a base sequence of SEQ ID NO: 1, an expression vector containing said promoter, and a recombinant microorganism transformed with said expression vector. The recombinant... Agent: Edwards Angell Palmer & Dodge LLP
20100196958 - Reduced phosphotransferase system activity in bacteria: A method of producing biological products using bacteria with an inactivated ptsHI and wild type err and no added glucose transport activity and which consumes nearly all glucose in the media is described. The ΔptsHI bacteria produce large quantities of recombinant protein without producing significant amounts of acetate. The bacteria... Agent: Baker & Mckenzie LLP
20100196955 - Scaleable manufacturing process for cysteine endoprotease b, isoform 2: Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization to yield a stable product.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP
20100196960 - Transporter genes oatp-b, c, d, and e: Four novel transporter genes were successfully cloned by screening novel transporter genes based on the human OATP transporter gene sequence. These transporters are useful in the development of drugs by taking advantage of the activity of transporting biological substances and various drugs. It was also found that these transporter genes... Agent: Klarquist Sparkman, LLP
20100196961 - Variable tangential flow filtration: The current invention reports a method for concentrating an immunoglobulin solution by tangential flow filtration wherein the transmembrane pressure and the cross-flow are variable.... Agent: Hoffmann-la Roche Inc. Patent Law Department
20100196962 - Il-6 receptor il-6 direct fusion protein: e
20100196963 - Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions: The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic conditions on a biocompatible surface in vitro. The culturing method produces both soluble and non-soluble fractions, which may be used separately or in combination to obtain physiologically acceptable compositions... Agent: Dla Piper LLP (us)
20100196964 - Method for the production of an aqueous glucose solution: The present invention relates to a process for the production of an aqueous glucose solution from maize or maize kernels. The invention also relates to a glucose solution obtainable by this process, and to its use for the production of organic compounds. The process according to the invention comprises: a)... Agent: Connolly Bove Lodge & Hutz, LLP
20100196965 - Acidophilic enzymes: The present invention relates to enzymes having catalytic activity at a pH below 5.0. The present invention provides hydrolyzing enzymes obtainable from archaeobacteria, in detail to hydrolytic enzymes obtainable from the archaeobacterium Ferroplasma acidiphilum. In general, the present invention provides enzymes which are active and stable at acidic pH values,... Agent: Greer, Burns & Crain
20100196966 - Plants which synthesize increased amounths of glucosaminglycans: The present invention relates to plant cells and plants which synthesize an increased amount of glucosaminoglycans, and to methods for preparing such plants, and also to methods for preparing glucosaminoglycans with the aid of these plant cells or plants. Here, plant cells or genetically modified plants according to the invention... Agent: Hunton & Williams LLP Intellectual Property Department
20100196967 - Fractionation of a lignocellulosic material: A method for fractionating a lignocellulosic material, the method comprising; contacting (2) the lignocellulosic material with an ionic liquid (3) and dissolving the lignocellulosic material therein, providing a second liquid (7) which is immiscible with the ionic liquid and is also a non-solvent for cellulose, adding the second liquid to... Agent: Sonnenschein Nath & Rosenthal LLP
20100196968 - Polypeptides having beta-glucosidase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes, Inc.
20100196969 - Method for obtaining energy-generating compounds by means of electromagnetic energy: The present invention relates to a process for obtaining energetic compounds by means of electromagnetic energy produced by sunlight or artificial light by means of using phytoplankton cultures.... Agent: Ladas & Parry LLP
20100196970 - Butynol i esterase: The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefor, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis... Agent: Novak Druce Deluca + Quigg LLP
20100196971 - Sequestration of compounds from microorganisms: The invention provides novel mesoporous particles and methods for the selective sequestration of organic compounds from microorganisms, such as from various genera and species of algae that produce important organic compounds. The organic compounds can be selectively sequestered, for example, in favor of biodiesel impurities such as sterols and chlorophyll,... Agent: Schwegman, Lundberg & Woessner, P.A.
20100196974 - Chemically inducible expression of biosynthetic pathways: Methods and constructs for the introduction of multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway are provided. In one embodiment, the constructs contain two or more enzyme-encoding genes, each under the control of an inducible promoter and each with a polyadenylation signal. The constructs are used to produce transgenic... Agent: Pabst Patent Group LLP
20100196973 - Methods for the synthesis of fatty diacids by the metathesis of unsaturated diacids obtained by fermentation of natural fatty acids: The invention relates to a method for the synthesis of diacids of general formula ROOC—(CH2)n—(CH═CH)n—(CH2)mCOOR1 in which n and m are identical or different and each represent an integer such that their sum is between 6 and 15, a is an index of 0 or 1, and R and R1... Agent: Arkema Inc. Patent Department - 26th Floor
20100196972 - Producing energy from biological material: Described are methods and systems for producing synthesis gas. In some embodiments, the method includes microbiologically converting biological material to form methane and CO2; and reacting methane and CO2 formed in (a) with water and metal to form synthesis gas. Optionally, the method also includes cutting vegetation; fermenting the vegetation... Agent: The Law Office Of Michael E. Kondoudis
20100196975 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.
20100196976 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.
20100196977 - Methods of producing isoprene and a co-product: The invention features methods producing isoprene and a co-product, such as ethanol, 1,3-propanediol, or hydrogen from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides compositions comprising isoprene and ethanol, isoprene and 1,3-propanediol, and isoprene and hydrogen. Additionally, the invention provides methods of co-producing... Agent: Morrison & Foerster LLP
20100196979 - Conversion of biomass into ethanol: A process and system for the conversion of biomass, such as spent brewers grain, into ethanol and other commercial products, such as pelletized fuel, biogas, fertilizer, and livestock feed, is disclosed. The method may include biomass pretreatment, hydrolysis, fermentation, distillation, and dehydration phases.... Agent: Stoel Rives LLP - Slc
20100196980 - Methods for producing fermentation products: The invention relates to methods for producing a fermentation product from a lignocellulose-containing material comprising i) pre-treating lignocellulose-containing material; ii) hydrolysing pre-treated lignocellulose-containing material; iii) fermenting using a fermenting organism; wherein fermentation is initiated and carried out at: a) a fermentation organism cell count in the range from 10-250×1010 cells... Agent: Novozymes North America, Inc.
20100196978 - Recombinant host cells and media for ethanol production: Disclosed are recombinant host cells suitable for degrading an oligosaccharide that have been optimized for growth and production of high yields of ethanol, and methods of making and using these cells. The invention further provides minimal media comprising urea-like compounds for economical production of ethanol by recombinant microorganisms. Recombinant host... Agent: Edwards Angell Palmer & Dodge LLP
20100196981 - Methods and systems for feedstock production from sewage and product manufacturing therefrom: A cellulosic feedstock composition including an oil content of up to 15% of the composition, a cellulose content of 40-99% of the composition, a hemicellulose content of 2-20% of the composition, a lignin content of less than 15% of the composition, a nitrogen containing organic compound content of less than... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100196982 - Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism: The present invention relates to methods for the production of isoprene by the direct conversion of atmospheric carbon dioxide using metabolically engineered genetically engineered photosynthetic microorganisms. The present invention also relates to genetically engineered photosynthetic microorganisms, such as cyanobacteria, that are capable of producing isoprene from CO2.... Agent: Morgan, Lewis & Bockius, LLP (sf)
20100196983 - Transformation of gram positive bacteria by sonoporation: The present invention provides a sonoporation-based method that can be universally applied for delivery of compounds into Gram positive bacteria. Gram positive bacteria which can be transformed by sonoporation include, for example, Bacillus, Streptococcus, Acetobacterium, and Clostridium. Compounds which can be delivered into Gram positive bacteria via sonoporation include nucleic... Agent: Scully Scott Murphy & Presser PC
20100196984 - Controlled electroporation and mass transfer across cell membranes: Electroporation is performed in a controlled manner in either individual or multiple biological cells or biological tissue by monitoring the electrical impedance, defined herein as the ratio of current to voltage in the electroporation cell. The impedance detects the onset of electroporation in the biological cell(s), and this information is... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP
20100196985 - Method and system for lactose-free or lactose-reduced milk and associated products, production thereof, and associated processes: A system and method capable of hydrolyzing lactose, where the system includes a support formed from a functionalized hydrophobic polymer that is covalently linked to a hydrophilic molecule covalently that is, in turn, covalently linked to an enzyme such as lactose. The method includes the steps of functionalizing a hydrophobic... Agent: Bond, Schoeneck & King, PLLC
20100196986 - Composition: s
20100196988 - Bioreactive agents: This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents... Agent: Medlen & Carroll, LLP
20100196987 - Mutant-type acetyltransferase mpr1: The present invention provides a mutant-type acetyltransferase Mpr1: which comprises an amino acid sequence of a yeast wild-type Mpr1 represented by SEQ ID NO:1, wherein at least one amino acid at positions 63 to 65 and 117 of the amino acid sequence is substituted and said mutant-type acetyltransferase Mpr1 exhibits... Agent: Wenderoth, Lind & Ponack, L.L.P.
20100196989 - Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof: The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as well as combinations with other suitable antibodies, are useful for the treatment and diagnosis of hepatocellular carcinoma, hepatoblastoma, germ cell tumors carcinoma and other AFP-producing tumors.... Agent: Immunomedics, Inc.
20100196990 - Protease variants: The present invention relates to methods for producing variants of a parent RP-II protease and the variants having altered properties as compared to the parent RP-II protease.... Agent: Novozymes North America, Inc.
20100196991 - Novel protein variants by circular permutation: The present invention relates to a method for obtaining novel protein variants by circular permutation, and to the novel protein variants obtained by said method.... Agent: Connolly Bove Lodge & Hutz LLP
20100196992 - Intergenic regions as novel sites for insertion of hiv dna sequences in the genome of modified vaccinia virus ankara: The invention relates to novel insertion sites useful for the integration of HIV DNA sequences into the MVA genome, and to the resulting recombinant MVA derivatives.... Agent: Law Office Of Salvatore Arrigo
20100196993 - Persistently infective sendai virus vector: A persistently infective virus vector is produced by using a gene so modified as to encode an amino acid sequence including a valine substituted for an amino acid residue at position-1618 in the amino acid sequence for an L protein of a persistently non-infective Sendai virus. A non-transmissible, persistently infective... Agent: Edwards Angell Palmer & Dodge LLP
20100196994 - Fungi cultivation on alcohol fermentation stillage for useful products and energy savings: A method of processing stillage from fermentation derived alcohol is disclosed, including dry-grind ethanol production from corn, by fermentation with filamentous fungi. This produces high-value fungal biomass that can be recovered by screening, is easily dewatered and used as an animal feed, human food or as a source of nutraceuticals.... Agent: Dorsey & Whitney LLP Intellectual Property Department
20100196995 - Systems and methods for maintaining the dominance and increasing the biomass production of nannochloropsis in an algae cultivation system: Systems and methods for maintaining the dominance and increasing the biomass production of Nannochloropsis in an algae cultivation system are provided. Exemplary methods include applying an effective amount of ozone to Nannochloropsis growing in an algae cultivation system. A further method may include applying a shock amount of ozone above... Agent: Carr & Ferrell LLP
20100196996 - Process for preserving biological materials for extended periods of time: The present invention provides for a process for preserving biological material. The process comprises subjecting the biological material to a fixation process and then packaging the biological material in a container under a controlled atmosphere of noble gas. In the process, the controlled atmosphere of noble gas utilized comprises one... Agent: Air Liquide Usa LLC Intellectual Property
20100196997 - Polymer extraction methods: A method of separating a polymer from a biomass containing the polymer, includes contacting the biomass with a solvent system, the solvent system including a solvent for the polymer and a precipitant for the polymer, to provide a residual biomass and a solution that includes the polymer, the solvent for... Agent: Foley & Lardner LLP
20100196998 - System and method for electroporating a sample: A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the system while the second electrode... Agent: Life Technologies Corporation C/o Intellevate
20100196999 - Reagent vessel: Provided is a reagent vessel which is inserted into a measuring cassette for measuring a biological sample. The reagent vessel includes: a reagent storage unit including at least one space in which a reagent that is to react with the biological sample is stored; and an adhesive cover sealing up... Agent: North Star Intellectual Property Law, PC
20100197001 - Gene detection field-effect device and method of analyzing gene polymorphism therewith: A gene detection field-effect device provided with an insulation film (2), a semiconductor substrate (3), and a reference electrode (4), includes: (a) the insulation film (2) including a nucleic acid probe (5) immobilized on one of the surfaces thereof and is in contact with a sample solution (6) containing at... Agent: Wenderoth, Lind & Ponack, L.L.P.
20100197000 - Membrane array and analytical device: A membrane array used to detect one or more analytes from a small sample of fluid with high sensitivity is provided. The membrane array can be employed in various analytical devices and is especially useful for identifying analytes from whole blood with minimal or negligible background interference.... Agent: Sim & Mcburney
20100197002 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: The Invention Science Fund Clarence T. Tegreene
20100197003 - Bioreactor: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.... Agent: King & Schickli, PLLC
20100197004 - Microtiter plate to mitigate cell distribution bias from meniscus edge: A lid assembly is provided for mitigation or removal of meniscus along the periphery of sample liquid in the cavity wells of a microtiter plate. The assembly includes a lid plate having a mount surface, an array of plugs corresponding to the array of wells, and a plurality of posts.... Agent: Naval Surface Warfare Center Office Of Counsel Code C7
20100197005 - Human monoclonal antibodies to activin receptor-like kinase-1: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and... Agent: Ropes & Gray LLP
20100197007 - Method for culturing mammalian stem cells: The invention relates to a method for culturing mammalian stem cells, in particular embryonic stem cells comprising the following steps: a) providing a perfused bioreactor (1) comprising a cell culture chamber (2); b) placing said mammalian stem cells within said culture chamber (2); c) providing a perfusion loop which provides... Agent: Mcandrews Held & Malloy, Ltd
20100197006 - Molecular circuits: Disclosed herein are autonomous molecular circuits that can function in cells. The circuits can process logical operations in which one or more input cues are among the operands and produce an appropriate output. Such circuits can be implemented in living cells, e.g., eukaryotic or prokaryotic cells that have been modified... Agent: David S. Resnick
20100197008 - Processing particle-containing samples: A microfluidic device includes an input port for inputting a particle-containing liquidic samples into the device, a retention member, and a pressure actuator. The retention member is in communication with the input port and is configured to spatially separate particles of the particle-containing liquidic sample from a first portion of... Agent: Knobbe Martens Olson & Bear LLP
20100197009 - Antibody or fragment thereof recognizing avitagtm and uses thereof: The application relates to antibodies which recognize the AviTag™ peptide of sequence MSGLNDIFEAQKIEWHE (SEQ ID No. 1) and to fragments thereof which recognize SEQ ID No. 1, wherein said antibodies or said fragments thereof recognize polypeptides containing SEQ ID No. 1 at their NH2 terminus and polypeptides containing SEQ ID... Agent: Mcandrews Held & Malloy, Ltd
20100197010 - Immortalized avian cell lines comprising e1a nucleic acid sequences: Immortalized avian cell lines containing E1A nucleic acid sequences are useful for the production of viruses and are particularly useful for the production of recombinant viral vectors which can be employed for the preparation of therapeutic and/or prophylactic compositions for the treatment of animals and more particularly humans.... Agent: Buchanan, Ingersoll & Rooney PC
20100197011 - Method of obtaining cell lines in a protein-free medium and cell lines thus obtained: A method of recovering mammalian cell clones adapted to serum and protein-free media is disclosed. The procedure includes a two-stage adaptation process to grow in that condition. A critical protein concentration interval is disclosed in which cells must grow in order to gain the capacity to survive in serum and... Agent: Walker & Jocke, L.p.a.
20100197012 - Application of rna interference targeting dhfr gene, to cell for producing secretory protein: Biological materials are applied to a CHO cell or the like for enhancing production of a species of protein. The biological materials includes an expression vector and a silencing vector, the expression vector including a dhfr gene of a species of mammal and a gene encoding the species of protein,... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP
20100197013 - Method for culturing stem cells: A three-dimensional microwell system that supports long term pluripotent cell culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured pluripotent cells remain viable and undifferentiated for several weeks in culture and maintain undifferentiated replication when passaged to Matrigel®-coated, tissue culture-treated polystyrene dishes. Microwell-cultured pluripotent cells maintain pluripotency, differentiating... Agent: Quarles & Brady LLP
20100197014 - Methods for increasing definitive endoderm production: Disclosed herein are methods for increasing the production of definitive endoderm cells from pluripotent stem cells. Also disclosed herein are agents capable of increasing definitive endoderm cell production.... Agent: Knobbe Martens Olson & Bear LLP
20100197015 - Human liver progenitors: Methods of isolating and cryopreserving progenitors from human liver are disclosed which include processing human liver tissue to provide a substantially single cell suspension comprising progenitors and non-progenitors of one or more cell lineages found in human liver; subjecting the suspension to a debulking step, which reduces substantially the number... Agent: Foley And Lardner LLP Suite 500
20100197017 - Method for sterilization of biological preparations: Provided is a method for the sterilization of a biological preparation including desired viable biological entities. The method includes irradiating a dried (e.g. freeze-dried) biological preparation with UV radiation at an intensity and for a duration sufficient to reduce the amount or activity of living-matter contaminants in the biological preparation,... Agent: The Nath Law Group
20100197016 - Structure enclosing hematopoietic progenitor cells from es cells and method for preparing blood cells using the same: An object of the present invention is to provide a sac-like structure enclosing hematopoietic progenitor cells and a method for preparing the sac-like structure as well as a method for efficiently preparing blood cells such as mature megakaryocytes and platelets from the sac-like structure. The present invention provides a sac-like... Agent: Pearne & Gordon LLP
20100197018 - Use of substrates as pharmacological chaperones: Provided is a method of enhancing the activity of lysosomal enzymes using substrates that are derivatives of natural substrates as pharmacological chaperones.... Agent: Hoffmann & Baron, LLP
20100197019 - Method for cultivation of hair follicular dermal sheath cells: A method for culture of hair follicular dermal sheath cells or precursor cells thereof which are potent cellular materials for such as hair regeneration by cell transplantation is provided. That is, by performing culture in an animal cell culture medium supplemented with platelet-derived growth factor AA (PDGF-AA) and fibroblast growth... Agent: Wenderoth, Lind & Ponack, L.L.P.
20100197021 - Keratin biomaterials for cell culture and methods of use: Provided are keratin compositions useful in cell culture. In some embodiments the keratins are biocompatible, promote cell growth, promote cell adhesion and provide an excellent substrate for cell culture. Keratin compositions described herein may be used as coatings, gels, three-dimensional scaffolds, additives to cell culture media, microcarriers, etc. The keratin... Agent: Myers Bigel Sibley & Sajovec
20100197020 - Tissue engineering tendon and construction methods in vitro thereof: The invention discloses a tissue engineering graft, comprising:(a) pharmaceutically-acceptable biodegradable material; and (b) seed cells, which can be inoculated on the described biodegradable material and are selected from:(i) fibroblasts; (ii) adipose derived cells, or (iii) mixture of dermal fibroblasts and ASCs according to the ratio of 1:10000-10000:1. The graft can... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20100197022 - Automated liquid manufacturing system: A method for continuously preparing a medium formulation mixes a diluent with a plurality of chemically incompatible concentrate solutions in such a manner that none of the ingredients of the concentrate solutions chemically react in an adverse manner. The method utilizes a static mixing chamber to add the concentrate solutions... Agent: Life Technologies Corporation C/o Intellevate
20100197023 - Modified polynucleotides for use in rna interference: Methods and compositions for performing RNA interference comprising a wide variety of stabilized siRNAs suitable for use in serum-containing media and for in vivo applications, such as therapeutic applications, are provided. These siRNAs permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the... Agent: Merchant & Gould PC
20100197024 - Apparatus and method for genetically transforming cells: A fluid containing cells and free genetic material is acoustically coupled to a propulsion surface of a diaphragm. A blast-receiving surface of the diaphragm is acoustically coupled to an explosion chamber in which an explosive material is disposed. An ignition system ignites the explosive material in the explosion chamber to... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLPPrevious industry: Education and demonstration
Next industry: Chemistry: analytical and immunological testing
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