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Chemistry: molecular biology and microbiology July category listing 07/10

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
07/29/2010 > patent applications in patent subcategories. category listing

20100190146 - Microfluidic glycan analysis: Microfluidic devices and methods for analyzing glycan profiles of glycoproteins are provided. Some embodiments of the devices comprise a deglycosylation column for cleaving glycans, an optional cleaning column for removing proteins, a trapping column for enriching glycans, and a separation column for resolving glycans. The devices and methods significantly improve... Agent: Agilent Technologies Inc.

20100190149 - Cross-reactive hybridization probe for detecting hiv-1 and hiv-2 nucleic acids in the p31 gene sequence: Cross-reacting hybridization probe for detecting HIV-1 and HIV-2 nucleic acids. The probe advantageously exhibited uniformly high signal-to-noise ratios when hybridized to HIV-1 and HIV-2 target nucleic acids. The probe can be used, for example, in screening applications for detecting donated blood contaminated with either of the two analytes.... Agent: Gen Probe Incorporated

20100190148 - Electrophoretic interactive spectral methods and devices for the detection and/or characterization of biological particles: Methods for identifying a biological particle in a sample medium include generating an Electrophoretic Quasi-elastic Light Scattering (EQELS) spectrum for the biological particle in the sample medium. The EQELS spectrum is compared to a reference database comprising a plurality of spectra, and each of the plurality of spectra correspond to... Agent: Myers Bigel Sibley & Sajovec

20100190147 - Method of determining immune enhancement of virus infectivity using fc receptor-transfected cell lines: The present invention relates to a method of detecting immune enhancement of virus infectivity, a method of determining neutralization and immune enhancement of virus infectivity, a method of identifying a virus epitope that displays immune enhancement, a method of identifying a compound that modulates activity of an Fc receptor, and... Agent: Nixon Peabody LLP - Patent Group

20100190174 - Adam12, a novel marker for abnormal cell function: The present application demonstrates in several examples the variation of the ADAM12 level in fetal abnormality and/or adverse pregnancy outcomes correlated gestational age when compared to normal controls. It is an object of the invention to provide an improvement of the existing marker tests that exhibits a decreased false positive... Agent: Frommer Lawrence & Haug

20100190178 - Altered recombinases for genome modification: The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20100190152 - Apparatus for analysing a sample and assessing its global position: An apparatus for analysing a sample and assessing its global position, the apparatus comprising a portable sample analysing device and a global positioning device.... Agent: Polsinelli Shughart PC

20100190150 - Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators: EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal the level of the at least one... Agent: Louis J. Wille Bristol-myers Squibb Company

20100190163 - Cancer antigen-specific t-cell receptor gene, peptide encoded by the gene, and use of them: Disclosed are: a nucleotide sequence and an amino acid sequence for CDR3 region of T-cell receptor (TCR) gene of WT1-specific cytotoxic T-cell (CTL) for WT1 protein; a method for the detection or treatment of cancer using the nucleotide sequence or the amino acid sequence; and a chip, a primer set,... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100190168 - Competitor molecules useful for lowering nonspecific adsorption of dye labeled nucleotides: Methods are described which enable higher signal/noise when performing surface measurements at the single molecule level. Methods are particularly useful in the field of molecular biology when performing single molecule nucleic acid sequencing by synthesis using dye labeled nucleotides. The method employs using a competitor molecule which blocks nonspecific binding... Agent: Lando & Anastasi, LLP

20100190154 - Development of low allergen soybean seeds using molecular markers for the p34 allele: A mutation in the gene encoding the P34 protein in soybean which affects allergenicity is characterized. Soybean homozygous for a mutant allele comprising a four base pair insertion at the start codon of the gene encoding the P34 protein, exhibit significantly reduced P34 protein accumulation. Nucleic acid samples of soybean... Agent: Usda-ars-office Of Technology Transfer National Ctr For Agricultural Utilization Research

20100190164 - Diagnosis and monitoring of renal failure using peptide biomarkers: Methods for the determination of renal failure, especially chronic renal failure and acute kidney injury, by measurement of peptide or protein biomarkers are described. The methods are useful to determine stages of renal failure, especially the early stages such as stage 1, 2, and 3 of chronic renal failure and... Agent: Wilmerhale/boston

20100190159 - Fluorescence-producing molecule: wherein R1 represents an alkyl group containing 1 to 6 carbon atoms, an amino group, an amide group optionally having a protecting group or a substituent, a halogen atom, or a hydrogen atom; R2 independently represents an alkyl group containing 1 to 6 carbon atoms, a halogen atom, or a... Agent: Greenblum & Bernstein, P.L.C

20100190151 - Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids: The invention provides methods for sequencing a nucleic acid, and particularly methods for synthesizing fluorescently labeled nucleoside triphosphates and related analogs for sequencing nucleic acids.... Agent: Milstein Zhang & Wu LLC

20100190173 - Gene expression markers for colorectal cancer prognosis: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.... Agent: Genomic Health, Inc. (bozicevic, Field & Francis) C/o Kathleen Determann

20100190172 - Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention... Agent: Celera Corporation

20100190160 - Indicator cell lines and methods for making same: Methods of making an indicator cell are described. The methods include, e.g., contacting a vertebrate cell comprising a functional endogenous target gene under control of an endogenous inducible promoter with a parvoviral vector comprising a construct comprising a targeting DNA sequence linked to a DNA encoding a reporter gene, wherein... Agent: Fish & Richardson PC

20100190179 - Lateral flow methods and devices for detection of nucleic acid binding proteins: Methods and devices are provided for detecting the presence or absence of nucleic acid binding proteins, such as NMP22, and other proteins, in bodily fluids.... Agent: Diehl Servilla LLC

20100190157 - Method for detection of mutant alleles combining real time pcr and rems-pcr: The instant invention refers to a method for simultaneous selective amplification and detection of mutant DNA sequences, to oligonucleotides to be used for said method and to kit for the same. The invention refers aldo to a method for identifying a specific mutated DNA sequence, to oligonucleotides to be used... Agent: Kenneth K. Sharples Law Office Of Kenneth K. Sharples

20100190155 - Methods and kits for measurement of lymphocyte function: The present invention provides simple and rapid methods for measuring the function of a desired subset of lymphocytes, for example, T cells, B cells or NK cells. In addition, the present invention provides an all-in-one kit that contains reagents which permit a rapid and reliable analysis of the functions of... Agent: Scully Scott Murphy & Presser, PC

20100190175 - Methods of random mutagenesis and methods of modifying nucleic acids using translesion dna polymerases: The invention is related generally to methods of amplifying or synthesizing or producing nucleic acid molecules using Translesion DNA polymerases. In particular, the invention relates to methods of introducing a random mutation into a nucleic acid and encoded polypeptide using Translesion DNA polymerases. The invention also relates to methods of... Agent: Life Technologies Corporation C/o Intellevate

20100190165 - Methods of screening compounds for bioactivity in organized tissue: The invention provides a method of screening a compound for bioactivity, comprising contacting a candidate bioactive compound with an organized tissue, and measuring in at least a cell of the organized tissue a biological parameter that is associated with bioactivity, wherein a change in the biological parameter that occurs as... Agent: Edwards Angell Palmer & Dodge LLP

20100190162 - Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease: This invention provides methods of diagnosing or predicting susceptibility to Inflammatory Bowel Disease by determining the presence or absence of genetic variants in the TL1A gene. In one embodiment, a method of the invention is practiced by determining the presence or absence of TL1A production following Fc-gamma-R activation. In another... Agent: Davis Wright Tremaine LLP/los Angeles

20100190167 - Methods, reagents and kits for detection of nucleic acid molecules: Methods, reagents and kits are provided for the production and use in detection assays of labeled nucleic acid molecules wherein a labeling molecule is attached directly to the 3′ end of the nucleic acid molecules.... Agent: Diehl Servilla LLC

20100190171 - Microorganism concentration process: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to about 0.5, as determined by X-ray photoelectron... Agent: 3m Innovative Properties Company

20100190170 - Microtiter plate mask and methods for its use: Provided is a masking system of masks for use with multiwell plates such as microtiter plates to facilitate sample dispensing and assay accuracy, especially when dispensing more than one solution into the wells. One or more masks, adapted in size to fit snugly over a multiwell plate and the mask... Agent: Greenlee Winner And Sullivan P C

20100190161 - Mutations in human ubiad1: The invention relates to polynucleotides and polypeptides which encode UBIAD1.... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20100190156 - Quality control of agricultural products based on gene expression: The invention relates to the field of quality testing of fresh plant-based and mushroom based products. Methods, carriers and kits for determining the quality stage are provided.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100190158 - Rapid test for detecting dna sequences: The present invention relates to an in vitro method for detecting a target DNA sequence in cells using an oligonucleotide which is labelled with a beta-D-galactopyranoside which, on hydrolysis of the glycosidic linkage, forms a water-insoluble dye. The invention relates in particular to an in vitro method for detecting a... Agent: Marshall, Gerstein & Borun LLP

20100190169 - Single nucleotide polymorphisms predicting cardiovascular disease: e

20100190153 - Single-molecule pcr on microparticles in water-in-oil emulsions: Modulation of the viscosity of the oil phase of a microemulsion used for amplification of DNA on a bead increases the homogeneity of product beads and the amount of amplified DNA per bead. Moreover the number of separate microemulsion populations that can be formed in parallel is increased using multi-well... Agent: Banner & Witcoff, Ltd.

20100190177 - Target activated microtransfer: A method of removing a target from a biological sample which involves placing a transfer surface in contact with the biological sample, and then focally altering the transfer surface to allow selective separation of the target from the biological sample. In disclosed embodiments, the target is a cell or cellular... Agent: Klarquist Sparkman, LLP

20100190166 - Tissue rejection biomarkers: This document relates to methods and materials involved in assessing tissue rejection (e.g., organ rejection) in mammals. For example, methods and materials involved in detecting tissue rejection (e.g., kidney rejection) are provided, as are methods and materials for distinguishing types of tissue rejection (e.g., antibody-mediated rejection versus T cell-mediated rejection)... Agent: Fish & Richardson P.C.

20100190176 - Tumor suppressor designated ts10q23.3: A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel... Agent: Myriad Genetics Inc. Intellectual Property Department

20100190181 - Biomarkers for preeclampsia: The present invention relates to novel biomarkers such as histidine and ketone bodies and methods of use thereof for detecting preeclampsia in pregnant individuals and for identifying individuals at risk at an early stage of pregnancy.... Agent: Myers Bigel Sibley & Sajovec

20100190182 - Diagnostic composition and method for the detection of a trichinella infection: A diagnostic composition to detect antibodies in a sample obtained from an animal or human being infected by Trichinella, comprising at least one peptide containing a series of amino acids that form a continuous or discontinuous epitope recognized by sera from pigs infected with Trichinella.... Agent: Rankin, Hill & Clark LLP

20100190180 - Materials and methods for screening, diagnosis and prognosis of conditions associated with stat protein expression: The subject invention concerns methods and materials for cancer screening using platinum complexes to detect a STAT protein biomarker. Platinum (IV) complexes interacting with STATs directly correlate with the STAT expression. In one embodiment, fluorescently-labeled and/or antibody-linked platinum (IV) complexes can be used to assess the STAT expression and define... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100190185 - Novel non-invasive marker for liver function and disease: A monoclonal antibody or fragment thereof, capable of specifically binding to at least one epitope of sH2a and/or being elicited by at least one epitope, and assays, kits, and methods of use thereof diagnosing liver disease or condition, detecting liver function and assessing the efficacy of therapy to a liver... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100190183 - Protein labelling with tags comprising isotope-coded sub-tags and isobaric sub-tags: Subject of the present invention are new isotopic and isobaric tagged molecules, kits comprising them and methods of using them in mass spectrometry.... Agent: Philips Intellectual Property & Standards

20100190184 - Screening method utilizing novel substrate c-ret for gamma-secretase: The present invention provides a method of screening for compounds which affect the processing of c-Ret by γ-secretase. The method involves contacting a first biological composition containing γ-secretase or a biologically active fragment thereof with a second biological composition containing c-Ret in the presence and absence of a candidate compound;... Agent: Darby & Darby P.C.

20100190186 - Method for pathogen capture from mammalian blood: Disclosed is a method for isolating, and thereby concentrating, microorganisms from mammalian blood. The method may be used in conjunction with PCR amplification of the DNA/RNA of the microorganism(s) to identify pathogenic microorganisms within the blood without requiring that those organisms be cultured as a first step in the identification... Agent: Donna J. Russell

20100190187 - Screening assays for antagonists and analyses of cardiac hypertrophy: Various embodiments of the present invention provide methods for screening for candidate heart failure compounds employing screening assays effective in identifying agonists or antagonists or ligands of vitamin D receptor mediated pathways implicated in heart failure. Methods are provided for the screening of test compounds that can specifically bind to... Agent: Harness, Dickey & Pierce, P.L.C

20100190188 - Mutant g-protein coupled receptors and methods for selecting them: A method for selecting a G-protein coupled receptor (GPCR) with increased stability, the method comprising (a) providing one or more mutants of a parent GPCR, (b) selecting a ligand, the ligand being one which hinds to the parent GPCR when the GPCR is residing in a particular conformation, (c) determining... Agent: Wolf Greenfield & Sacks, P.C.

20100190189 - Methods for detecting biomolecules in a sample: The invention develops a high-throughput screening method based on charcoal-sorbent peptide binding assay (CPBA) which does not need a solid phase and can simultaneously detect plural target biomolecules in a sample. The method of the invention can achieve high-throughput screening of biomolecules (such as antibodies and antigens) with a molecular... Agent: Wpat, PC Intellectual Property Attorneys

20100190190 - Food sensitivity testing in animals: Diagnosing an immunologic food sensitivity or intolerance in companion animals comprises collecting a sample; screening the sample to detect the presence of an antibody to a particular food ingredient or composition. The sample can be serum, saliva or other bodily fluid to detect the presence of an IgA, IgM or... Agent: Greenberg Traurig LLP (la)

20100190191 - Multi-stage nutrigenomic diagnostic food sensitivity testing in animals: A multi-stage method for diagnosing an immunologic food sensitivity or intolerance in a companion animal. Firstly a saliva or other non-serum bodily fluid sample is collected. The screening the saliva or other non-serum bodily fluid sample detects the presence of at least one of IgA or IgM antibody to a... Agent: Greenberg Traurig LLP (la)

20100190192 - Method of diagnosing pre-eclampsia: The present invention relates to a marker for the development of pre-eclampsia. In particular the invention provides a marker for the development of pre-eclampsia, which marker consists of a polypeptide of approximately 26.6 Kd as determined by 15-30% gradient SDS-PAGE under reducing conditions.... Agent: Edwards Angell Palmer & Dodge LLP

20100190193 - Diagnostic composition and its use in the determination of coagulation characteristics of a test liquid: The present invention is directed to a diagnostic composition for use in the viscoelastic analysis of a test liquid, and to a container (1) comprising same. The composition comprises at least an activator of coagulation, and, optionally CaCl2 an optionally, one or more inhibitors and/or coagulation components, wherein the composition... Agent: Joyce Von Natzmer Pequignot + Myers LLC

20100190194 - Postprandial hyperglycemia marker, method of measuring the same, and usage thereof: A new method of diagnosing postprandial hyperglycemia by indirectly measuring a blood glucose level is provided. Postprandial hyperglycemia is detected by measuring a glycation degree of lysine in hemoglobin, in which a side chain amino group of lysine is glycated (GHbLys %). Measurement of GHbLys % can be performed by... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100190195 - Use of hepatitis b x-interacting protein (hbxip) in modulation of apoptosis: Novel methods of regulating cellular apoptosis by affecting the interaction of hepatitis B X-interacting protein (HBXIP) with Survivin are described. More specifically, these novel methods of enhancing apoptosis of neoplastic cells comprises inhibiting interaction of hepatitis B X-interacting protein (HBXIP) with Survivin using siRNA or antisense compounds.... Agent: Dla Piper LLP (us)

20100190196 - D-serine dehydratase and use thereof: A novel D-serine quantification method that can overcome various disadvantages of a conventional D-serine quantification method; a novel enzyme that can be used in the D-serine quantification method; a gene encoding the enzyme; and the like. Specifically, a novel D-serine dehydratase including (a) a protein having an amino acid sequence... Agent: Edwards Angell Palmer & Dodge LLP

20100190198 - Asymmetric systems: Among other things, a combination comprises interaction with a system that has a perturbation. In such perturbed system, a non-directional input is applied to a first variable of the system. Based on an asymmetry of the perturbed system, a directional effect is achieved in a second variable of the system,... Agent: Fish & Richardson PC

20100190203 - Chemical amendments for the stimulation of biogenic gas generation in deposits of carbonaceous material: Methods of stimulating biogenic production of a metabolic product with enhanced hydrogen content are described. The methods may include accessing a consortium of microorganisms in a geologic formation that includes a carbonaceous material. They may also include providing hydrogen and one or more phosphorous compounds to the microorganisms. The combination... Agent: Townsend And Townsend And Crew, LLP

20100190200 - Diagnosis of gynecological neoplasms by detecting the levels of oviduct-specific glycoprotein: The present invention provides a method for detecting cancer in a patient. A sample from the patient is provided, and the level of oviduct-specific glycoprotein (OGP) in the sample is determined and compared to a control sample. Increased levels of OGP in the sample as compared to the control indicates... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20100190199 - Gpr30 estrogen receptor in breast and ovarian cancers: A method of prognosis for ovarian or breast cancer patients is carried out by detecting GPR30 in a sample of tissue. An elevation in the level of GPR30 compared to a normal control level indicates presentation of late stage disease and indicates responsiveness of the tumor to hormonal therapy.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100190201 - Methods: The invention relates to a method of detecting an altered behaviour in a population of cells, said method comprising determining at least one of the following characteristics of the population of cells; (i) the proportion of stem cells, proliferating cells and differentiated cells in said cell population; or (ii) the... Agent: Mcandrews Held & Malloy, Ltd

20100190197 - Nested permeable support device and method for using the nested permeable support device: A nested permeable support device is described herein that can be used to perform various experiments to test new therapeutic compounds (new chemical entities). In one application, the nested permeable support device is used to perform a first pass assay to determine the bioavailability of a new chemical entity following... Agent: Corning Incorporated

20100190202 - Novel population of hepatocytes derived via definitive endoderm (de-hep) from human blastocysts stem cells: The present disclosure relates to a novel hepatocyte-like cell progenitor and/or a novel hepatocyte-like cell derived via definitive endoderm from human blastocyst-derived stem (hBS) cells, to a method for the preparation of such cells and to the potential use of such cells in, e.g., pharmaceutical drug discovery and development, toxicity... Agent: Buchanan, Ingersoll & Rooney PC

20100190204 - Detection and identification of microorganisms on transparent permeable membranes: This invention describes rapid detection and identification of colonies or micro-colonies of microorganisms after regular or short (several hours) growth periods on light pellucid, molecule-permeable membranes installed on solid nutrient media. Colonies or micro-colonies appearing on a membrane can be easily transferred from a growth plate to another media such... Agent: Eckert Seamans Cherin & Mellott

20100190205 - Tissue cassette label: A multilayer label comprising a polymeric film or cloth, e.g., a polyester film or a polyester woven cloth, having opposing facial surfaces, one facial surface of which is in intimate contact with a xylene-resistant, water-based topcoat and the other facial surface of which is in intimate contact with a pressure... Agent: Whyte Hirschboeck Dudek S C Intellectual Property Department

20100190206 - Process for the preparation of immobilized recombinant penicillin acylase catalyst from achromobacter sp. ccm 4824 expressed in e. coli bl 21 ccm 7394 and its use for the synthesis of beta-lactam antibiotics: The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIP1 and processing of PA into biocatalyst useful for the industrial synthesis of antibiotics. More particularly the invention discloses a synthesis of semi-synthetic... Agent: Law Offices Of Albert Wai-kit Chan, PLLC

20100190208 - Acid fungal proteases: The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for... Agent: Danisco US Inc. Attention: Legal Department

20100190207 - Expression augmenting dna fragments, use thereof, and methods for finding thereof: The invention provides recombinant DNA molecules comprising novel expression augmenting DNA fragments and an expression cassette, said expression cassette comprising a heterologous promoter linked to a nucleic acid of interest. The invention further provides uses of the novel expression augmenting DNA fragments. The invention further provides methods for obtaining novel... Agent: Traskbritt, P.C.

20100190209 - Optimized dna sequences encoding recombinant human bone morphogenetic protein-2 (rhbmp-2), preparation method and the uses thereof: The invention discloses an optimized DNA sequence of recombinant human bone morphogenetic protein-2 (rhBMP-2) based on the Escherichia coli expression system and a method for the preparation of the rhBMP-2. Specifically, the invention provides the optimal DNA sequences suitable for Escherichia coli expression system, the methods for efficient preparation of... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100190211 - Il-18 receptors: A novel polypeptide that functions as an IL-18 receptor is disclosed. The receptor is multimeric and includes at least one AcPL polypeptide, or fragment thereof, and at least one IL-1Rrp1 polypeptide, or fraction thereof. The receptor binds IL-18 and finds use in inhibiting biological activities mediated by IL-18.... Agent: Immunex Corporation Law Department

20100190210 - Protein purification: The present invention provides methods for purifying proteins. In particular, the methods employ a two-step non-affinity ion exchange chromatography process without the use of an in-process tangential flow filtration step.... Agent: Lahive & Cockfield, LLP/medarex Floor 30, Suite 3000

20100190212 - Method of controlling the content of selected component(s) from polymer(s) using molecular sieve(s): e

20100190214 - Biochemical treatment apparatus and method comprising liquid handling mechanism: Nucleic acid solution, magnetic particles solution and primer or eluate are moved between a lot of wells provided in reaction/storage vessel 3 by pipette device 40 to perform the first PCR, purification and the second PCR. In the time point where the first PCR and purification end, pipette tip 42... Agent: Fitzpatrick Cella Harper & Scinto

20100190213 - Method and apparatus for controlling the temperature of reaction volumes: A method and apparatus for controlling the temperature of one or more reaction volumes contained in respective reaction vessel(s) through absorption of electromagnetic energy by a reactant medium of the reaction volume(s). The method comprises providing one or more-reaction volumes (1) in respective reaction vessel(s) (3) such. that the reaction... Agent: Nixon Peabody, LLP

20100190215 - Penetrable cap: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible... Agent: Gen Probe Incorporated

20100190217 - Method for producing l-lysine: L-Lysine is produced by culturing in a medium an Escherichia coli having an L-lysine-producing ability, which has been modified to decrease the activity or activities of one or more enzymes of the meso-α,ε-diaminopimelic acid synthesis pathway, for example, 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, succinyldiaminopimelate transaminase, succinyldiaminopimelate desuccinylase, and diaminopimelate epimerase, and into which... Agent: Cermak Nakajima LLP Acs LLC

20100190216 - Method for production of l-lysine using methanol-utilizing bacterium: A method for production of L-lysine is provided which includes the steps of cultivating a methanol-utilizing bacterium in a culture medium to produce and accumulate L-lysine in the culture medium and collecting the L-lysine from the culture medium, wherein the methanol-utilizing bacterium contains DNA encoding dihydrodipicolinate synthetase which is desensitized... Agent: Cermak Nakajima LLP Acs LLC

20100190218 - Enone reductases: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.... Agent: Codexis, Inc.

20100190219 - Production of sphingoid bases using genetically engineered microbial strains: The present invention provides genetically engineered microbial strains, in particular genetically engineered yeast strains, that produce at least 0.5 mg per g CDW of a sphingoid base according to Formula I or a salt or ester thereof. The present invention provides a method to obtain genetically engineered microbial strains producing... Agent: Scully Scott Murphy & Presser, PC

20100190220 - Method for producing epa-enriched oil and dha-enriched oil: Alcoholysis of oils and fats containing EPA and DHA is performed by a lipase having substrate specificity for fatty acids having 18 carbons or less and in the presence of a reaction additive such as magnesium oxide; then the glyceride fraction is separated; alcoholysis of the glyceride fraction is performed... Agent: Cantor Colburn, LLP

20100190221 - Method for producing polyhydroxyalkanoic acid: Embodiments of the invention relate to the microbial production of polyhydroxyalkanoic acids, or polyhydroxyalkanoates (PHA), from substrates which cannot be used as a source of carbon and/or energy for microbial growth or PHA synthesis and which have microbial and environmental toxicity. According to one embodiment of the invention, a process... Agent: Knobbe Martens Olson & Bear LLP

20100190222 - Lactic acid production method: Disclosed is a lactic acid production method by separating lactic acid produced in a culture solution by means of the fermentation culture of a microorganism. Specifically disclosed is a lactic acid production method, which comprises: a step (A) of filtering the culture solution through a nano-filtration membrane; and a step... Agent: Ip Group Of Dla Piper LLP (us)

20100190223 - Yeast for transformation, transformation method, and method for producing substance: Yeast for transformation is provided, which enables introduction of a greater number of copies of a target gene or a greater number of types of target genes. A method provided herein comprises the steps of introducing a target gene into yeast for transformation, which has homothallic properties and a plurality... Agent: Sughrue Mion, PLLC

20100190224 - enzyme for the production of methylmalonyl-coenzyme a or ethylmalonyl-coenzyme a and use thereof: The invention further relates to a vector, the use of this vector for transformation of a cell, a transformed cell, a polypeptide, cells genetically engineered relative to their wild type, a method of production of a genetically engineered cell, the genetically engineered cell obtainable by this method, the use of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100190225 - D-psicose production method by d-psicose epimerase: Provided is a method of producing D-psicose using a D-psicose epimerase derived from Agrobacterium tumefaciens. Provided are a protein having an amino acid sequence of SEQ ID NO:1 and having a psicose 3-epimerase activity, a gene encoding the protein, a recombinant expression vector containing the gene, and a method of... Agent: Cantor Colburn, LLP

20100190226 - Process for producing a pretreated feestock: A process for producing ethanol from a pretreated feedstock is provided. The feedstock is selected from grasses, cereal straws, stover, and combinations thereof, and least about 80% of the feedstock has a particle length of between about 2 cm and about 40 cm. This process comprises wetting the feedstock in... Agent: Fitzpatrick Cella Harper & Scinto

20100190227 - Photoreactor: The invention relates to photoreactors (1) comprising LED plastic moulded parts (6) in which at least one LED luminous body (7) is incorporated into a plastic matrix, as a radiation source arranged inside the photoreactor.... Agent: Ratnerprestia

20100190228 - Method and apparatus for facilitating evaluating migration of cells in vitro: Method and apparatus for processing a cell culture are provided. The method includes establishing a cell culture within a holding device having one or more wells, each well holding a cell culture, and including a well substrate with at least one electrode in contact with the cell culture; periodically applying... Agent: Heslin Rothenberg Farley & Mesiti PC

20100190229 - System for optical stimulation of target cells: Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target... Agent: Crawford Maunu PLLC

20100190230 - Potent and selective neuronal nitric oxide synthase inhibitors with improved membrane permeability: Compounds and related compositions and methods as can be used to inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator

20100190231 - Methods for crystallizing erk2 polypeptides: The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.... Agent: Merck Patent Department (k-6-1, 1990)

20100190234 - methods for the formation of disulphide bonds: The present invention relates to methods for the formation of inter-molecular disulphide bonds, including (poly)peptides/proteins, nucleic acids, vectors, host cells and bacteriophages used in these methods. Furthermore the invention relates to the use of this method for the improved display of (poly)peptides/proteins on the surface of bacteriophage particles.... Agent: Morphosys Ag

20100190232 - Functional mutations in respiratory syncytial virus: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins... Agent: Medimmune, LLC Patrick Scott Alban

20100190233 - M13 bacteriophage as a chemoaddressable nanoparticle for biological and medical applications: Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage.... Agent: Dority & Manning, P.A.

20100190235 - Methods for designing and operating photobioreactor systems: The invention may include methods of configuring and operating a photobioreactor system with modular photobioreactor units or blades. The invention may also include apparatus and methods of controlling the photobioreactor system and optimizing growth conditions through a support structure and backplane interface.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100190236 - System for producing microorganisms: e

20100190237 - Compositions and methods for storage of bacterial suspensions: A medium composition is provided. The medium composition comprising about: NaCl/KCl 1.0-3.0%; Inositol/lactose/trehalose/dextran 0.5-7.0%; Mg/Ca 0.0-300 mM; Yeast Extract/Casamino acids 0.01-0.05%; BSA/egg albumin 0.02-1.0%; and Ethanol/methanol/propanol 0.1-3.5%.... Agent: Fleit Gibbons Gutman Bongini & Bianco Pl

20100190238 - Synthesis of mycophenolic acid (mpa): The present invention relates to novel tools for improving MPA production. In particular, the present invention relates to fungal enzymes that are specific for MPA synthesis.... Agent: Knobbe Martens Olson & Bear LLP

20100190239 - Degradation of nanomaterials: A method of degrading carbon nanomaterials includes mixing the carbon nanomaterials with a composition comprising a peroxide substrate and at least one catalyst selected from the group of an enzyme and an enzyme analog. The peroxide substrate undergoes a reaction in the presence of the catalyst to produce an agent... Agent: Henry E. Bartony, Jr

20100190240 - Reagents for nucleic acid purification: Embodiments of the present invention provide methods and kits for purifying nucleic acids. In particular, embodiments of the present invention provide methods and kits for purifying nucleic acids through the use of magnetic particles in binding buffers.... Agent: Casimir Jones, S.c.

20100190241 - Bioactive carbon dioxide filter apparatus and method therefor: A bioactive filter is provided which comprises a transparent canister having gas permeable membranes as entry and exit ports. A source of carbon dioxide in gaseous form is allowed to enter the entry membrane and pass through a solution contained in the canister which supports a live colony of algae.... Agent: George R. Schultz Schultz & Associates, P.C.

20100190242 - System for division of a volume of liquid into drops and subsequent drop recollection: We describe a system for the division or partition of a volume of fluid into droplets of assigned size and subsequent recollection of the drops.... Agent: Andrea Adamo

20100190244 - Riboswitches, methods for their use, and compositions for use with riboswitches: It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches”... Agent: Patent Correspondence Arnall Golden Gregory LLP

20100190243 - Sirna-mediated gene silencing with viral vectors: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.... Agent: Viksnins Harris & Padys Pllp

20100190246 - Method for preparing biological tissue: This invention provides a method for obtaining biological tissue having a three-dimensional structure of interest. The method of the invention comprises: adding a cell-containing culture solution to a culture vessel having an inner bottom surface, which is non-cell adhesive and comprises a concave-convex pattern provided thereon; performing cell culture under... Agent: Sughrue Mion, PLLC

20100190245 - Method to increase dissolved oxygen in a culture vessel: Basing on study of a previous discovered effective bioreactor system, a method to increase culture medium dissolved oxygen is disclosed. This method together with addition of an optimal mixing forms a theoretical foundation for effective bioreactor design and prototype construction.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100190247 - Methods of generating variant proteins with increased host string content: The present invention relates to novel methods for generating variant proteins with increased host string content, and proteins that are engineered using these methods.... Agent: Morgan, Lewis & Bockius, LLP (sf)

20100190249 - Method and device for forming a three-dimensional arrangement of biological cells: A method for forming a three-dimensional cell arrangement (1) of biological cells is disclosed, including the steps of preparation of the cell arrangement (1) on a flexible substrate (10) and deformation of the substrate (10), wherein the deformation of the substrate (10) is brought about by an attractive force exerted... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20100190248 - Methods for the cryopreservation of animal cells that contain high levels of intracellular lipids: A method for cryopreservation of animal cells with high level of intracellular lipid content, comprises the steps of conducting a delipation procedure using one or more lipolytic agent(s) and/or lipogenesis inhibitors during culture of the animal cells to stimulate the hydrolysis of intracellular lipids to reduce the lipid content, and... Agent: Maginot, Moore & Beck, LLP Chase Tower

20100190251 - Method for the differentiation of human adult stem cells into insulin-secreting cells: Disclosed is a method for differentiating human adult stem cells into insulin-secreting cells. Human adult stem cells, isolated from the subcutaneous adipose tissues around the eyes, are induced to differentiate into insulin-secreting cells in a medium in the presence of cytokines and growth factors including B27 supplement, fibroblast growth factor-2,... Agent: Lowe Hauptman Ham & Berner, LLP

20100190250 - Methods of rejuvenating cells in vitro and in vivo: The present invention provides methods for rejuvenating cells, tissues and the whole body. Also provided are rejuvenating buffers and agents as well as kits for rejuvenating cells. Also provided are methods for dedifferentiating somatic cells and differentiating the cells into other cell types.... Agent: The Luther Law Firm, PLC

20100190252 - Methods for the preparation of fibroblasts: The invention relates to a process for generating fibroblasts, more particularly, to the culturing of fibroblasts in large numbers and of the heterogenic type. The invention is also directed to the use of fibroblasts in the preparation of heterotypic spheroids and a process for the preparation of such heterotypic spheroids.... Agent: Ratnerprestia

20100190253 - Cell culture container and cell culture method: To provide a cell culture chamber and a cell culture method that are capable of effectively constructing an intercellular network in a culture space. A cell culture chamber (10) according to the present invention is a cell culture chamber (10) including a plurality of microchambers (11) formed on a surface... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100190254 - Three-dimensional porous hybrid scaffold and manufacture thereof: The present invention refers to a three-dimensional porous hybrid scaffold for tissue engineering and methods of its manufacture and use.... Agent: Pabst Patent Group LLP

20100190255 - Cross-linked gums for hepatocyte culture: This disclosure relates to cell culture surfaces derived from or contain gums including naturally occurring gums, plant gums, galactomannan gums or derivatives thereof including carboxyalkyl guar gum. Even more particularly, the disclosure relates to chemically or physically cross-linked modified gums where the gum surfaces are tuned to provide cell culture... Agent: Corning Incorporated

20100190256 - Method for culturing mammalian taste cells: The invention provides methods of culturing mammalian taste cells, including taste receptor cells. Cells are maintained for a duration of up to three months and longer while maintaining molecular and functional characteristics of mature taste cells. The cells are cultured on coated cell culture vessels and, from first replacement of... Agent: Woodcock Washburn LLP

20100190258 - Method of producing recombinant biological products: A method of producing a recombinant biological product, which method employs a mammalian producer cell culture, comprises the steps of generating a biomass of mammalian producer during an initial phase of cell culture, and causing an increase in a level of one or more of the miRNA molecules of Table... Agent: Knobbe Martens Olson & Bear LLP

20100190257 - Self-assembly of a cell-microparticle hybrid: The present invention provides a fabrication method for the formation of a cell-microparticle hybrid. A biotin-avidin binding system also employs the use of a biodegradable polymer and any cell type that self-assemble to form a hybrid system.... Agent: Dr. Aliasger K Salem Yogita Krishnamachari

20100190259 - Ethanol production: The present invention relates to the production of ethanol as a product of bacterial fermentation. In particular this invention relates to a novel method of gene inactivation and gene expression based upon homologous recombination. The method is particularly useful in connection with species of Bacillus such as B. stereothermophilus, B.... Agent: Banner & Witcoff, Ltd.

  
07/22/2010 > patent applications in patent subcategories. category listing

20100184012 - Methods and devices for imaging and manipulating biological samples: Methods of imaging biological samples are provided. Aspects of embodiments of the methods include freezing, thawing and imaging a biological sample, one or more times, in a manner sufficient to image the biological sample while maintaining the viability and/or structural integrity of the sample. Also provided are devices and systems... Agent: Bozicevic, Field & Francis LLP

20100184013 - Detection of oligosaccharides: Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100184018 - Detection of herpes simplex virus: The invention provides methods to detect herpes simplex virus (HSV) in biological samples and further to distinguish between HSV-1 and HSV-2. Primers and probes for the differential detection of HSV-1 and HSV-2 are provided by the invention. Articles of manufacture containing such primers and probes for detecting HSV are further... Agent: Fish & Richardson P.C.

20100184017 - Differential amplification of mutant nucleic acids by pcr in a mixture of nucleic acids: A method for enriching a mutant nucleic acid in a mixture of nucleic acids, wherein the method comprises: (a) providing a nucleic acid mixture comprising a parental nucleic acid and a mutant nucleic acid of the parental nucleic acid; and (b) amplifying the nucleic acids in the nucleic acid mixture... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100184015 - Method for detection of xmrv: The present invention relates to the identification of Xenotropic murine leukemia virus (XMRV) nucleic acid by polymerase chain reaction (PCR) analysis (e.g., real time PCR (RT/PCR); nested RT/PCR using Tth DNA polymerase and Hot start polymerase) and the uses thereof. In particular, the invention provides methods for the detection, and... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100184016 - Methods and compositions in the treatment of porcine circoviral infection: e

20100184014 - Non-m, non-o hiv-1 strains, fragments and uses:

20100184019 - Novel human virus causing severe acute respiratory syndrome (sars) and uses thereof: The present invention relates to an isolated novel virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). The hSARS virus is identified to be morphologically and phylogenetically similar to known member of Coronaviridae. The present invention provides the complete genomic sequence of the hSARS virus. Furthermore, the invention... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100184077 - Allelic form of the hmga2 gene predisposing women to the formation of leiomyomas: The present invention is directed to diagnostic assays that can be used to determine if a woman carries an allelic form of the HMGA2 gene that predisposes her to the formation of fibroid tumors. The invention also encompasses vectors containing this allele, cells transformed with these vectors and transgenic animals... Agent: Law Office Of Michael A. Sanzo, LLC

20100184066 - Assay for trichomonas vaginalis by amplification and detection of trichomonas vaginalis ap65-1 gene: A region of the Trichomonas vaginalis AP65-1 gene has been identified which is useful for performing amplification assays to determine specifically whether T. vaginalis is present in the sample being tested. Oligonucleotides useful for performing thermal Strand Displacement Assay (tSDA) reactions on this gene are disclosed. The disclosed oligonucleotides can... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100184054 - Binding of pathological forms of prion proteins: A process for the selective binding of an aggregating abnormal form of a protein in the presence of the nonaggregating normal form of the protein, including contacting under selective binding conditions a material containing both the abnormal and normal forms with a binding agent which is a polyionic material having... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20100184020 - Chip-based sequencing nucleic acids: A system for fast DNA sequencing by amplification of genetic material within microreactors, denaturing, demulsifying, and then sequencing the material, while retaining it in a PCR/sequencing zone by a magnetic field. One embodiment includes sequencing nucleic acids on a microchip that includes a microchannel flow channel in the microchip. The... Agent: Lawrence Livermore National Security, LLC

20100184026 - Companion diagnostic assays for endothelin receptor antagonists: Methods for identifying cancer patients eligible to receive endothelin receptor antagonist therapy and for monitoring patient response to endothelin receptor antagonist therapy comprise assessment of the expression levels of at least one of PAI-1, uPA, TGFbeta2, IL-6, IL-8 and OPG in a patient tissue sample. The methods of the invention... Agent: Vysis, Inc Patent Department

20100184071 - Compartmentalized self tagging: The present invention relates to the development of a novel method for the selection of nucleic acid processing and other enzymes. In particular the invention relates to a method for the selection of nucleic acid polymerases and other enzymes with desired properties based on the method of compartmentalized self-tagging.... Agent: Edwards Angell Palmer & Dodge LLP

20100184059 - Compositions: A composition for carrying out a chemical or biochemical reaction, said composition being in a freeze-dried form and comprising (i) a set of reagents comprising at least some of the chemical or biochemical reagents necessary for conducting said chemical or biochemical reaction, including at least one reagent which is fluorescent... Agent: Polsinelli Shughart PC

20100184040 - Compositions and methods for determining likelihood of twinning: Collections of polynucleotides useful for estimating breeding value or detecting likelihood of twinning are disclosed. The polynucleotides are used to detect genomic sequences quantitatively associated with the twinning trait. Also disclosed are methods and kits for using the collections to estimate breeding value or predict likelihood of twinning.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20100184037 - Death associated protein kinase 1 (dapk1) and uses thereof for the treatment of chronic lympocytic leukemia: A method for determining susceptibility to chronic lymphocytic leukemia in a subject includes determining a loss or reduced expression of death associated protein kinase 1 (DAPK1) or fragments or functional equivalents thereof.... Agent: Macmillan Sobanski & Todd, LLC

20100184043 - Detecting genetic abnormalities: The present invention is directed to compositions and methods for detecting genetic abnormalities. The present invention encompasses methods and compositions for comparing alleles in a sample containing both maternal and fetal nucleic acids in order to identify genetic abnormalities.... Agent: Morgan, Lewis & Bockius, LLP (sf)

20100184044 - Detecting genetic abnormalities: The present invention is directed to compositions and methods for detecting genetic abnormalities. The present invention encompasses methods and compositions for comparing alleles in a sample containing both maternal and fetal nucleic acids in order to identify genetic abnormalities.... Agent: Morgan, Lewis & Bockius, LLP (sf)

20100184050 - Diagnosis and treatment of inflammatory bowel disease in the puerto rican population: This invention provides methods of diagnosis and treatment of inflammatory bowel disease. In one embodiment, the invention provides methods of diagnosing and/or predicting susceptibility for inflammatory bowel disease in the Puerto Rican population by determining the presence or absence of a risk variant at the HPS1 locus. In another embodiment,... Agent: Davis Wright Tremaine LLP/los Angeles

20100184064 - Dna molecules encoding ligand gated ion channels from dermacentor variabilis: The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding D. variabilis LGIC/GluCl channels, substantially purified forms of associated D. variabilis channel... Agent: Judy Jarecki-black, Ph.d., J.d. Merial Ltd.

20100184048 - Epidermal growth factor (egf) expression and/or polymorphisms thereof for predicting the risk of developing cancer: The present invention relates to diagnostic and prognostic methods to determine the likelihood of a subject who has a inflammatory disease or liver disease of developing cancer. In particular, the present invention relates to methods for identifying subjects with increased susceptibility to developing cancer, such as hepatocellular carcinoma (HCC) where... Agent: David S. Resnick

20100184034 - Gene expression profiling for identification, monitoring and treatment of lung cancer: A method is provided in various embodiments for determining a profile data set for a subject with lung cancer or conditions related to lung cancer based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100184081 - Genetic markers for obesity: The present invention is directed to new genetic variants or polymorphisms at the perilipin locus (PLIN) including PLIN1: 6209T (allele 1)>C (allele 2); PLIN3 10171 (allele 1) A >T (allele 2); PLIN4: 11482G (allele 1)>A (allele 2); PLIN5: 13041A (allele 1)>G (allele 2) and PLIN6: 14995A (allele 1)>T (allele 2),... Agent: David S. Resnick

20100184049 - Glycoprotein profiling of bladder cancer: The present invention relates to a method for the diagnosis, prognosis, and monitoring of bladder cancer, such as early or late stage bladder cancer, by detecting in a urine sample from a subject at least one biomarker for bladder cancer identified herein, such as alpha-1B-glycoprotein, haptoglobin, serotransferrin, or alpha-1-antitrypsin. The... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100184075 - Haplotype analysis: The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic acid markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these... Agent: Ronald I. Eisenstein

20100184022 - Hybridization probe assay and array: e

20100184053 - Identification and quantification of oncogenic hpv nucleic acids by means of real-time pcr assays: Method for the identification and quantification of oncogenic HPV nucleic acids comprising: a) first line screening by means of 5 independent SYBR Green I Real-time PCR assays to determine the total viral load and to identify the presence of one or more of 13 high risk HPV genotypes in the... Agent: Lucas & Mercanti, LLP

20100184028 - Method and system for real time quantification and monitoring of nucleic acid amplification using electroconductive or electrochemically active labels: A method and device for real time electrochemically or electrically monitoring and detecting nucleic acid amplification products, i.e. after each polymerase chain reaction cycle, utilizes electrochemically active or electrically conductive reporter materials. An electric voltage is applied and electric signals are measured during a PCR amplification process to the electrodes... Agent: EagleIPLimited

20100184055 - Method for distinguishing follicular thyroid adenoma (fta) from follicular thyroid carcinoma (ftc): Follicular thyroid adenoma (FTA) is distinguished from follicular thyroid carcinoma (FTC) by comparing amount of an expression product of at least one gene selected from the group consisting of DDIT3, ARG2, ITM1, C1orf24, TARSH, and ACO1 in a test follicular thyroid specimen to a normal control thyroid specimen. The test... Agent: Banner & Witcoff, Ltd.

20100184062 - Method for identifying and quantifying organic and biochemical substances: The invention relates to a method for identifying organic or biochemical substances and for determining their concentration in a fluid medium using a nanogap sensor that comprises at least two electrodes. The invention is characterized in that: a nanogap sensor) with electrodes of different materials is used, a respective probe... Agent: Lerner Greenberg Stemer LLP

20100184025 - Method for screening for a tobiano coat color genotype: A method for screening for a Tobiano genotype includes obtaining a nucleic acid from an equine animal, and analyzing the nucleic acid for the presence of an inversion in a chromosome ECA3q which is indicative of the genotype for Tobiano. The method includes detecting at least one of a telomeric... Agent: King & Schickli, PLLC

20100184060 - Method for the identification of propane-oxidizing bacteria: The invention relates to a method for the identification of propane-oxidizing bacteria which is based on the identification of at least one fragment of the prmA gene encoding the alpha subunit of the propane monooxygenase enzyme and/or the prmD gene encoding an ancillary protein involved in the oxidation reaction of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100184024 - Method of characterizing nucleic acids in a mixed sample: e

20100184072 - Method of detection of predisposition to emphysema in chronic obstructive pulmonary disease: The present invention relates to a method of detection of predisposition to emphysema in chronic obstructive pulmonary disease (COPD). It particularly relates with the regulation of the key molecular and biochemical components of the pathway leading to the manifestation of emphysema in COPD.... Agent: Merchant & Gould PC

20100184068 - Method of measuring reverse-transcribed single stranded dna, method of measuring reverse transcriptase activity and kit for the same: Provided are a method of measuring a single stranded DNA reverse-transcribed from a RNA using RNaseH, RNaseT1, and RNase A, a method of measuring activity of a reverse transcriptase, and kits for the same.... Agent: Cantor Colburn, LLP

20100184065 - Method of predicting non-response to first line chemotherapy: The invention provides a method for determining a prognosis of colorectal cancer in a colorectal cancer patient, comprising classifying said patient as having a good prognosis or a poor prognosis using measurements of a plurality of gene products in a cell sample taken from said patient, said gene products being... Agent: Smith Hopen, Pa

20100184030 - Method, compositions and kits for increasing efficiency or specificity of hybridization between pna probes immobilized on support and target nucleic acids: Disclosed are a process for increasing efficiency or specificity of hybridization between peptide nucleic acid (PNA) probes immobilized on a support and target nucleic acids, which comprises the step of fragment the target nucleic acids to reduce the size of the target nucleic acids, or selectively degrading the target nucleic... Agent: Clark & Brody

20100184029 - Methods and compositions for identifying biomarkers useful in characterizing biological states: The present invention relates to methods, compositions, and kits for identifying biomarkers useful in characterizing biological states. In particular, the invention relates to methods and compositions for molecular characterization of biological states by gene expression profiling. The invention also relates to assessing effects of DNA polymorphisms on regulation of transcription.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100184039 - Methods and compositions relating to labeled rna molecules that reduce gene expression: The present invention concerns methods and compositions involving labeled, double-stranded RNA (dsRNA), including siRNA, capable of triggering RNA-mediated interference (RNAi) in a cell. Compositions of the invention include labeled dsRNA for RNAi, which may be a single strand of RNA that basepairs with itself or two separate RNA strands. In... Agent: Life Technologies Corporation C/o Intellevate

20100184070 - Methods and devices for diagnosis of appendicitis: A method is provided for diagnosing appendicitis in a patient that includes identifying at least one symptom of appendicitis in the patient and identifying the presence of at least one molecule differentially associated with appendicitis in a fluid or tissue sample of said patient. MRP-8/14 and haptoglobin are examples of... Agent: Greenlee Winner And Sullivan P C

20100184027 - Methods and nucleic acids for analyses of cellular proliferative disorders: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and... Agent: Davis Wright Tremaine, LLP/seattle

20100184057 - Methods and probes for identifying a nucleotide sequence: The present invention provides a method for identifying a set of target nucleotide sequences capable of identifying a member of a group of related nucleotide sequences, the method comprising the step of dividing the nucleotide sequence of each member of the group into a plurality of subsequences, wherein at least... Agent: The Firm Of Hueschen And Sage

20100184046 - Methods and systems of using exosomes for determining phenotypes: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific... Agent: Wilson, Sonsini, Goodrich & Rosati

20100184036 - Methods for detecting nucleic acid sequences: The present invention provides methods and kits for detecting the presence or absence or amount of a target nucleic acid or at least one variant nucleotide in one or more target nucleic acids contained in a sample using appropriate primers. The invention is based on systems whereby there is extension-dependent... Agent: Michael Best & Friedrich LLP

20100184035 - Methods for rapid forensic dna analysis: The present invention provides methods and primer pairs for rapid, high-resolution forensic analysis of DNA and STR-typing by using amplification and mass spectrometry, determining the molecular masses and calculating base compositions of amplification products and comparing the molecular masses with the molecular masses of theoretical amplicons indexed in a database.... Agent: Casimir Jones, S.c.

20100184045 - Methods for sequencing degraded or modified nucleic acids: The invention provides methods and compositions for sequencing DNA or RNA samples that would be impossible to do via standard means. Samples that are part of mixtures or are degraded or modified may be sequenced so that the individual from whom the sample originated can be determined or useful biological... Agent: Brown Rudnick LLP

20100184080 - Methods of detecting charcot-marie tooth disease type 2a: Methods are described for screening a subject for risk of Charcot-Marie-Tooth Disease Type 2A or for diagnosing Charcot-Marie-Tooth disease or a predisposition for developing Charcot-Marie-Tooth disease in a subject, by detecting the presence or absence of a mutation in the mitofusin gene in a biological sample collected from the subject.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100184051 - Methods of generating pluripotent cells from somatic cells: Disclosed herein are methods to select for the generation of mouse and human pluripotent stem cells during developmental reprogramming. The methods described herein relate to the selection of induced pluripotent stem cells, i.e., pluripotent stem cells generated or induced from differentiated cells without a requirement for genetic selection. Described herein... Agent: David S. Resnick

20100184033 - Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby: Aspects of the present invention relate to methods to differentiate pluripotent primordial stem cells, such as human embryonic stem (“hES”) cells, human embryonic germ (“hEG”) cells, human embryo-derived (“hED”) cells and human embryonal carcinoma (“hEC”) cells, to obtain subpopulations of cells from heterogeneous mixtures of cells, wherein the subpopulation of... Agent: Bozicevic, Field & Francis LLP

20100184041 - Molecular indicators of breast cancer prognosis and prediction of treatment response: The present invention relates to quantitative molecular indicators that can guide clinical decisions in breast cancer, such as estrogen receptor (ESR1)-positive, lymph node-negative breast cancer. In particular, the invention concerns certain genes, the varied expression of which indicates the likelihood of recurrence of surgically resected breast cancer in patients who... Agent: Genomic Health, Inc. (bozicevic, Field & Francis) C/o Kathleen Determann

20100184031 - Novel adipocytokine visfatin/pbef1 is an apoptosis associated factor induced in monocytes during in vivo hiv-1 infection: The present invention relates to the use of monocyte markers for diagnostic, prognostic or theranostic applications during diseases and syndromes caused by HIV infection. More specifically, it relates to a method comprising isolation of monocytes and determining gene expression, preferably PBEF1 gene expression. The method is useful to determine the... Agent: Traskbritt, P.C.

20100184021 - Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis: The present invention relates to diagnostic markers comprising novel splice variants of known proteins and polynucleotides encoding same, useful in the qualitative and/or quantitative detection of various diseases and/or pathological conditions in a subject, and to the use of known proteins and polynucleotides encoding same for diagnosis. Particularly, the invention... Agent: Fennemore Craig

20100184078 - Oligonucleotide sequences that identify species of animal: The present invention provides a method for identifying animal species, said method comprises a step of amplifying a DNA fragment by PCR using a DNA in a sample as a template and animal-specific DNA sequences as a primer pair, wherein the animal-specific DNA sequences are derived from a ATP synthase... Agent: Turocy & Watson, LLP

20100184058 - Peripherical tissue sample containing cells expressing the 5htr2c and/or adars as markers of the alteration of the mechanism of the 5htr2c mrna editing and its applications: The present invention relates to an in vitro method for predicting a pathology related to an alteration of the mechanism of the mRNA editing of ADAR dependent A to I mRNA editing, particularly the serotonin 2C receptor (5HTR2C), in a patient from a peripherical tissue sample containing cells expressing said... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100184069 - Preservation of fetal nucleic acids in maternal plasma: A method for preserving and processing fetal nucleic acids located within maternal plasma is disclosed, wherein a sample of maternal blood containing fetal nucleic acids is treated to reduce both cell lysis of the maternal blood cells and deoxyribonuclease (DNase) and ribonuclease (RNase) activity within the fetal nucleic acids. The... Agent: Dobrusin & Thennisch PC

20100184067 - Primer evaluation method, primer evaluation program, and real-time polymerase chain reaction apparatus: A primer evaluation method includes: acquiring a signal indicating time change in an amplification amount obtained when sample sets prepared for the number of temperature conditions that should be made different from each other at an annealing stage in units of target nucleic acids diluted in a stepwise manner are... Agent: K&l Gates LLP

20100184073 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20100184042 - Processes for quantitative or qualitative detection of single-stranded nucleic acids: This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the... Agent: Metz Lewis, LLC

20100184063 - Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy: The application provides methods of prognosing and classifying lung cancer patients into poor survival groups or good survival groups and for determining the benefit of adjuvant chemotherapy by way of a multigene signature. The application also includes kits and computer products for use in the methods of the application.... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20100184052 - Prognostic gene expression signature for non small cell lung cancer patients: The invention relates to a method of typing non-small cell lung cancer cells by determining RNA levels for a set of genes. Said typing can be used for determining a metastasizing potential of the cancer cells. The invention further relates to a set of probes and a set of primers... Agent: Hoffmann & Baron, LLP

20100184023 - Prostate specific gene, pcgem1, and methods of using pcgem1 to detect, treat, and prevent prostate cancer: A nucleic acid sequence that exhibits prostate-specific expression and over-expression in tumor cells is disclosed. The sequence and fragments thereof are useful for detecting, diagnosing, preventing, and treating prostate cancer and other prostate related diseases. The sequence is also useful for measuring hormone responsiveness of prostate cancer cells.... Agent: Latimer Intellectual Property Law, LLP

20100184061 - Reagent and reagent kit for analysis of immature leukocyte: n

20100184056 - Sample collection and measurement in a single container by back scattering interferometry: This invention provides a device and method for collection and analysis of heterogeneous samples in a single sample container by back scattering interferometry. The sample container is configured to allow collection of a heterogeneous sample, such as blood, from a subject, separation of insoluble materials, such as blood cells by,... Agent: Quine Intellectual Property Law Group, P.C.

20100184047 - Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex: The present invention is based on the observation that the co-activation of CDCA8 and AURKB, and their cognate interactions, play a significant role in lung-cancer progression. Accordingly, inhibiting the formation of the CDCA8-AURKB complex finds utility in the treatment of non-small-cell lung cancer. The present invention also provides methods for... Agent: Townsend And Townsend And Crew, LLP

20100184076 - Soluble analyte detection and amplification: The present invention relates to a method of detection of a compound of interest that is present at low levels in a sample. In particular, the present invention relates to a method of detection of a compound of interest in solution by a nucleic acid-labelled binding construct, separation of the... Agent: T. D. Foster

20100184079 - Soybean event 3560.4.3.5 and compositions and methods for the identification and detection thereof: Compositions and methods related to transgenic glyphosate/ALS inhibitor-tolerant soybean plants are provided. Specifically, soybean plants having a 3560.4.3.5 event which imparts tolerance to glyphosate and at least one ALS-inhibiting herbicide are provided. The soybean plant harboring the 3560.4.3.5 event at the recited chromosomal location comprises genomic/transgene junctions having at least... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20100184032 - Stem-progenitor cell specific micro-ribonucleic acids and uses thereof: Provided herein are methods and compositions for modulating the differentiation of incompletely differentiated cells, such as stem-progenitor cells, e.g., hematopoietic stem-progenitor cells. A method may comprise contacting a cell with an agononist or an antagonist of a miRNA comprising a nucleotide sequence from SEQ ID NO: 1-34.... Agent: Foley Hoag, LLP (w/jhv)

20100184038 - System and method for the heterologous expression of polyketide synthase gene clusters: A system and method for heterologous expression of polyketide biosynthetic pathways from streptomycetes hosts in Escherichia coli for the production and discovery of secondary metabolites. Genomic DNA from Streptomyces rimosus encoding the oxytetracycline biosynthetic pathway is inserted into the genome of the surrogate host Myxococcus xanthus. The M. xanthus transcriptional... Agent: Bond Schoeneck & King, PLLC

20100184074 - Universal nucleotides for nucleic acid analysis: The invention includes methods and kits for making and analyzing primer extension products incorporating one or more universal bases, including methods and kits for nucleic acid sequencing and microsatellite analysis.... Agent: Life Technologies Corporation C/o Intellevate

20100184082 - Antibody and immunoassays for determining the presence of delta9-tetrahydrocannabinol: Antibodies having specific binding for the parent THC (Δ9-THC) and its major metabolites are provided which present a significant increase in sensitivity of immunoassays such as lateral flow immunoassays and ELISA for THC. The present invention also provides a rabbit hybridoma producing the antibody as a monoclonal antibody, a recombinant... Agent: Varian Inc. Legal Department

20100184086 - Early detection of canine lyme disease by specific peptides and antibodies: The present invention relates, in one aspect, to the detection of Lyme disease in canines by detecting the peptide or antibodies to an infection specific peptide after challenge with B. burgdorferi. The 20 kDa peptide is not detectable in human sera samples after challenge or infection with B. burgdorferi and,... Agent: Kevin Farrell Pierce Atwood

20100184084 - Methods for measuring platelet reactivity of individuals treated with drug eluting stents: A method is provided for measuring inhibition of platelet reactivity in an individual treated with a drug-eluting stent (DES). First, a blood sample is obtained from an individual treated with a DES and a P2Y12 antagonist. The blood sample is then mixed with particles comprising an attached GPIIb/IIIa receptor ligand,... Agent: Cooley LLP Attn: Patent Group

20100184085 - Prokaryotic collage-like proteins and uses thereof: The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host... Agent: Benjamin Aaron Adler Adler & Associates

20100184083 - Released cytokeratins as markers for epithelial cells: The present invention is directed to methods of detecting viable epithelial cells in a sample. The method includes isolating the sample comprising cells from a patient and culturing the cells for a time sufficient for an epithelial cell-specific marker to be released from the cells. The marker includes a substantially... Agent: Brinks Hofer Gilson & Lione

20100184087 - Haptens, hapten conjugates, compositions thereof and method for their preparation and use: A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties... Agent: Klarquist Sparkman, LLP

20100184097 - 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells, a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identif: The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells, a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation. More specifically, it relates to 2-{2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole... Agent: Cantor Colburn, LLP

20100184092 - Methods and compositions for detecting receptor-ligand interactions in single cells: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The... Agent: Bozicevic, Field & Francis LLP

20100184098 - Methods for measuring enzyme activity: The invention relates to fluorescence methods for measuring enzyme activity, in particular enzyme cleaving and joining activities. The invention also relates to fluorogenic substrates which are useful for measuring enzyme activity and as in vitro and in vivo imaging probes.... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100184096 - Screening methods using sitosterolemia susceptibility gene (ssg) polypeptides: The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, SSG. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the... Agent: Amgen Inc. Law Department

20100184095 - Steroid hormone assay method: The level of a steroid hormone, including estrogen, in the stratum corneum of the skin is assayed by LC-MS analysis of a steroid hormone in the stratum corneum of the skin collected by a tape stripping method. This allows the concentration in the skin of the steroid hormone, including estrogen... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100184093 - Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition: Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts whether a patient is likely to have a favorable pathological stage of prostate cancer, where the model is based on features including... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20100184094 - Use of mdck cells in the evaluation of cholesterol modulators: A novel use for MDCK cells in the evaluation of cholesterol modulators is provided. In particular, methods for detecting substances which bind to NPC1L1 and block intestinal cholesterol absorption are provided. Such substances are of use in the treatment of individuals with hypercholesterolemia. The various assays may additionally be employed... Agent: Merck

20100184099 - Reagents and methods for cancer prognosis and pathological staging: This invention provides reagents and methods for assessing tumor progression using tissue or tumor cell-containing samples from an individual. The invention also provides reagents and methods for assessing response to chemotherapy.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100184100 - Tyrosine kinome: Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in −20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were... Agent: Banner & Witcoff, Ltd.

20100184101 - Detection of antigens carried by erythrocytes and of anti-erthrocyte antibodies: The invention relates to a method for detecting a plurality of antigenic molecules carried by erythrocytes and/or a plurality of anti-erythrocyte antibodies, said antigenic molecules carried by the erythrocytes consisting of antigenic molecules carried not only by the erythrocytes, but also by at least one other cell population, other than... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100184102 - Device and method for identifying and determining blood groups: A device for the determination and/or the detection of erythrocyte blood groups from a whole blood sample, and a process that implements this device, as well as a kit for the determination and the detection of blood groups are disclosed.... Agent: Young & Thompson

20100184103 - Methods of use of solid support material for binding biomolecules: Functionalized solid support material with biomolecule-binding groups and uses thereof, wherein the biomolecule-binding groups include a plurality of aromatic groups, an amine group which bonds to a biomolecule through an aldehyde group, a hydrazine group which bonds to a biomolecule through an aldehyde group, or an alpha,beta-ethylenically or acetylenically unsaturated... Agent: 3m Innovative Properties Company

20100184089 - Diagnosis and monitoring of chronic renal disease using ngal: A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as... Agent: Hasse & Nesbitt LLC

20100184088 - Methods of identifying agents that modulate methylation of vegfr1 by smyd3: The present invention relates to methods for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of VEGFR1 by SMYD3. The invention further provides methods and pharmaceutical compositions for treating and preventing colorectal cancer, hepatocellular carcinoma, bladder cancer... Agent: Townsend And Townsend And Crew, LLP

20100184090 - Method for generating stable cell lines expressing high levels of a protein of interest: This invention relates to industrial production of proteins. More specifically, the invention relates to a method for obtaining cells that stably express a protein of interest, even when cultivated in the absence of selective pressure. DHFR is used as a surrogate marker. The transfected cells are not selected based on... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100184091 - Method for determining mif content: The present invention relates to diagnostic methods for determining migration inhibitory factor (MIF) mRNA content in a sample, wherein MIF is human MIF polypeptide having a molecular weight of approximately 12.5 kDa and kits for detecting MIF.... Agent: Law Office Of John K. Pike, PLLC

20100184105 - Assessing neuronal damage from blood samples: Neuronal damage is detected by providing a biological sample derived from the subject, detecting in the sample the presence of a neurofilament subunits or their breakdown products, and correlating the presence and level of the neurofilament subunits and their breakdown products detected with the degree of neuronal injury.... Agent: Gregory A. Nelson Novak Druce & Quigg LLP

20100184104 - Nanoelectronic-enzyme linked immunosorbent assay system and method: The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100184106 - Thrombin substrate and assay for determining the level of bioactive thrombin in a sample: Substrates for thrombin and assays for determining the level of bioactive thrombin in a sample are disclosed, wherein the substrate has the general formula: A-X-Z-A′ wherein one of either A or A′ comprises a luminescent chelate and the other one of A or A′ comprises a first partner of a... Agent: Morgan Lewis & Bockius LLP

20100184107 - Protein trafficking: The present invention relates, in general, to protein trafficking, and, in particular, to a method of measuring protein trafficking to and from a plasma membrane.... Agent: Nixon & Vanderhye, PC

20100184108 - Methods and compositions relating to enzyme assays: Methods of assaying enzyme-mediated oxidative demethylation are provided according to embodiments of the present invention which includes combining, under reaction conditions, an oxidative demethylation enzyme, a substrate for the oxidative demethylation enzyme and a formaldehyde detection reagent. Detection of fluorescence is indicative of formaldehyde generated by oxidative demethylation of the... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20100184109 - Acquisition method for biological rhythm information: A simple low-invasive method for acquiring information about a biological rhythm of a bion is provided. In the method, the information on a biological rhythm of the bion is acquired based on variation with time of the activity of a biologically active agent, particularly alpha-amylase, extracted from oral mucosa epithelial... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100184111 - Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof: The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein concentrations. The present invention further discloses methods for generating crystals of the modified TACE protein in protein-ligand complexes with a number of inhibitors. In... Agent: Merck Patent Department (k-6-1, 1990)

20100184110 - Predictive diagnostics for kidney disease: The present invention relates to markers for kidney disease.... Agent: Siemens Corporation Intellectual Property Department

20100184112 - Novel affinity based method for drug target identification: Drug affinity responsive target stability (DARTS) is a novel method of drug target ID with several significant advantages over current techniques. In certain embodiments the method involves contacting a sample comprising one or more protein target(s) with a test agent to form a sample/test agent mixture; contacting the mixture with... Agent: Weaver Austin Villeneuve & Sampson LLP

20100184120 - Apparatus and method to characterize blood and red blood cells via erythrocyte membrane fragility quantification: u

20100184118 - Blood collector device and blood analysis procedure: The present invention provides an improved arterialized earlobe blood collection device, and an improved process for blood analysis. The device and the process of the invention can be used in many unsual and/or risky situations, including collecting arterialized blood in space missions under microgravity environment and within ambulances or the... Agent: Smith, Gambrell & Russell

20100184115 - Cell-impedance sensors: Methods and apparatus for designing and measuring a cell-electrode impedance sensor to detect chemical and biological samples, including biological cells. The method of designing a cell-electrode impedance sensor comprises: determining a cell free cell-electrode impedance and a cell-covered cell-electrode impedance; obtaining a sensor sensitivity of the cell-electrode impedance measurement system;... Agent: Fish & Richardson, PC

20100184113 - Controlling osteogenesis by inhibition of osteogenic suppressors: The present invention provides methods of screening for agents that inhibit the activity or expression of one or more polypeptides that contribute to the suppression of osteogenesis. The invention also provides methods of inducing osteogenesis in a cell by administering to the cell an agent that inhibits one or more... Agent: Townsend And Townsend And Crew, LLP

20100184116 - Fluorescent protein: The present invention provides a fluorescent protein having an amino acid sequence of the green fluorescent protein, the yellow fluorescent protein or mutants thereof wherein the 46th phenylalanine residue is substituted with a leucine residue. According to the present invention, there are provided novel GFP or YEP mutants having an... Agent: Leydig Voit & Mayer, Ltd

20100184122 - Indicator for assessing body odor, process for producing the same, body odor assessment method, method of assessing efficaciousness of deodorant and kit for conveniently assessing body odor: A method of assessing body odor using as an index an indicator material comprising an alcohol compound having a mercapto group at the 3-position represented by the following formula (2) and/or a substance that is a derivative of an alcohol compound having a mercapto group at the 3-position, wherein an... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100184119 - Laser mediated sectioning and transfer of cell colonies: Disclosed herein are methods and devices for sectioning cell colonies. Also disclosed are methods of purifying cell colonies. A method of sectioning cell colonies can include providing a cell colony on a culture plate comprising a known thickness; positioning a bottom of the culture plate using automated focus technology; and... Agent: Knobbe Martens Olson & Bear LLP

20100184117 - Method and system for characterizing a pigmented biological tissue: determining, from the measurement, of the content of the first compound in the tissue, wherein the method includes at least one compensation of a measurement saturation due to too high an absorption of the measurement radiation by the first compound, the compensation comprising a choice, for the measurement radiation, of... Agent: Young & Thompson

20100184114 - Method for screening allergic disease-related molecule and cell lines to be used in the method: An allergic disease-related substance is screened from candidate substances based on the reactivity to a plurality of cell lines, which are basophil-like or mast cell-like cell lines derived from the same spleen tissue and have different sensitivities to allergic cytokines. Further, an allergic disease-related substance is screened from candidate substances... Agent: Solaris Intellectual Property Group, PLLC

20100184121 - Removal of by-products from crosslinkable preparations: The present invention relates to the use of enzymes and/or whole-cell catalysts for the removal of undesired by-products from crosslinkable preparations.... Agent: Henkel Corporation

20100184123 - Gas exchange detection method and device: The invention relates to a gas exchange detection method and device particularly, but not exclusively, for rapid detection of the presence of micro-organisms, the effect of an additional substance upon a micro-organism and/or the rate at which oxygen is consumed, in solutions, aqueous emulsions and/or suspensions.... Agent: Peters Verny , L.L.P.

20100184124 - Detection of bacteria or somatic cells in organic samples by atp based luminescence: A method of testing an organic sample to provide an indication of the level of bacteria and/or number of somatic cells present in the sample, the method including collecting the sample and contacting the sample with a reagent which reacts with ATP to produce light emissions, and subsequently, at the... Agent: Goodman, Allen & Filetti PLLC

20100184126 - sampling device: A portable sampling device (2) for obtaining a biological sample from a subject comprises sample collection means (8) for excising a biological sample (14) from a subject, and sample containment means (6) for containing excised sample (14) and sample preservative (12) for preserving excised sample. The sample collection means (8)... Agent: Nixon Peabody LLP - Patent Group

20100184125 - Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators: IGF1R biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises (a) exposing the mammal to the IGF1R modulator and (b) measuring in the mammal the level of the at... Agent: Louis J. Wille Bristol-myers Squibb Company

20100184127 - Microtome sectionable biopsy support for orienting tissue samples: Tissue orientation devices include a perforated tissue support with at least one perforated channel for receiving a tissue sample, and a plurality of tabs configured to extend along and into the channel to retain the tissue sample during processing and embedding. Tissue orientation devices include elongated legs coupled together for... Agent: Wood, Herron & Evans, LLP

20100184131 - Amendment-free sludge composting: A composting system for promoting aerobic microbial activity in a composting bed. The system includes at least one composting bay for receiving composting material and an agitator for aerating and displacing composting material as it travels through the composting bay. Compost produced by the system is used in place of... Agent: Lando & Anastasi, LLP U0105

20100184130 - Engineered biomass with increased oil production: The present invention relates to a genetically modified plant having an increased amount of oil in its green biomass as compared to the oil in the green biomass of its non-genetically modified counterpart. The plants may be used for producing bio-fuels such as biodiesel fuel.... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20100184128 - Production of products of pharmaceutical interest in plant cell cultures: The present invention relates to transgenic plant cell cultures comprising transgenic plant cells comprising a plurality of nucleic acids heterologous to said plant, each of said nucleic acids comprising a coding sequence encoding a pharmaceutical product of interest operably linked to one or more regulatory elements for directing expression of... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20100184129 - Silicon moulded part comprising luminous bodies: The invention relates to moulded parts containing a plurality of luminous bodies incorporated into a silicon matrix, the silicon matrix consisting of an inner soft silicon matrix A which is surrounded by at least one hard silicon matrix B. The silicon matrix B is optionally coated with a top coat... Agent: Ratnerprestia

20100184134 - Dual charging system for selectively introducing non-native amino acids into proteins using an in vitro synthesis method: This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to... Agent: Townsend And Townsend And Crew, LLP

20100184132 - Enzymatic process for debittering of protein hydrolysate using immobilized peptidases: A method for enzymatic debittering of protein hydrolysates comprising the steps of isolating the protein hydrolysates from animal and plant source, reacting the said protein hydrolysates with peptidases immobilized on calcium alginate beads packed in a column.... Agent: The Webb Law Firm, P.C.

20100184133 - Method for making maturated insulin polypeptides: The invention is related to a method for making mature human insulin or an analogue thereof by culturing a fungi cell comprising a DNA sequence encoding a precursor for human insulin or an analogue of human insulin which precursor comprises the B-chain of human insulin or an analogue thereof, the... Agent: Novo Nordisk, Inc. Intellectual Property Department

20100184135 - Mono charging system for selectively introducing non-native amino acids into proteins using an in vitro protein synthesis system: This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to... Agent: Townsend And Townsend And Crew, LLP

20100184139 - Basb082 polynucleotides: The invention provides BASB082, BASB083, BASB091, BASB092 and BASB101 polypeptides and polynucleotides encoding BASB082, BASB083, BASB091, BASB092 and BASB101 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.... Agent: Seed Intellectual Property Law Group PLLC

20100184140 - Compositions of aminoacyl-trna synthetase and uses thereof: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20100184138 - Heterologous and homologous cellulase expression system: The present invention provides filamentous fungi that express a combination of heterologous and homologous polypeptides, polypeptide mixtures comprising a combination of heterologous and homologous polypeptides and methods of producing the polypeptide mixtures.... Agent: Danisco US Inc. Attention: Legal Department

20100184136 - Methods for enhancing a secretion efficiency of recombinant foreign protein in yeast expression system: Provided is a method for improving secretion efficiency of a recombinant foreign protein in a yeast expression system. The method comprises transforming a yeast host with a recombinant foreign gene construct comprising a galactose-inducible promoter, a secretion signal sequence and a gene encoding the foreign protein to construct a transformed... Agent: Sughrue Mion, PLLC

20100184137 - Modified secretion system to increase expression of polypeptides in bacteria: The present invention provides methods of altering the production of desired polypeptides in a host cell. In particular, the present invention provides polynucleotides encoding truncated SecG proteins capable of facilitating the secretion of desired proteases by a bacterial host cell, such as Bacillus species, as well as expression vectors and... Agent: Danisco US Inc. Attention: Legal Department

20100184142 - Bacteria with increased levels of protein secretion, nucleotide sequences coding for a seca protein with increased levels of protein secretion, and method for producing proteins: The invention relates to bacteria that have increased levels of protein secretion due to genetic modification, to nucleotide sequences and gene structures containing at least one gene coding for a SecA protein having increased levels of protein secretion, to a SecA having increased levels of protein secretion, and to a... Agent: Danisco US Inc. Attention: Legal Department

20100184141 - Serum-free stable transfection and production of recombinant human proteins in human cell lines: The present invention relates to an improved method for the serum-free production of an immortalized human cell line stably transfected under serum-free conditions with a specific vector carrying the gene coding for the protein of interest. Furthermore the invention relates to a production cell line obtained by said method, a... Agent: Thompson Hine L.L.P. Intellectual Property Group

20100184146 - Plasmid for expressing thioredoxin fusion protein and method for producing target protein using same: The present invention provides a plasmid for expressing a thioredoxin fusion protein comprising thioredoxin as a fusion partner, an E. coli cell transformed with the plasmid, and an efficient method for producing a target protein using the E. coli cell. The method according to the present invention can easily remove... Agent: Sughrue Mion, PLLC

20100184145 - Antibody-based therapeutics with enhanced adcc activity: Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100184144 - Immunoglobulin production: The current invention comprises a nucleic acid encoding the amino acid sequence of the C-terminal part of the CH3-domain of an immunoglobulin of the class IgA or IgG, or the C-terminal part of the CH4-domain of an immunoglobulin of the class IgE or IgM, wherein the glycine-lysine-dipeptide comprised in the... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100184143 - Immunoglobulins comprising predominantly a man3glcnac2 glycoform: The present invention relates to immunoglobulin glycoprotein compositions having predominant N-glycan structures on an immunoglobulin glycoprotein which confer a specific effector function. Additionally, the present invention relates to pharmaceutical compositions comprising an antibody having a particular enriched N-glycan structure, wherein said N-glycan structure is Man3GlcNAc2.... Agent: Merck

20100184147 - Method for controlling ph, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield: Methods for controlling the level of dissolved carbon dioxide and limiting osmolality in a mammalian cell culture process to enhance cell growth, viability and density, and increase biologic product concentration and yield are provided. Such control of the level of dissolved carbon dioxide and pH as well as the resulting... Agent: Praxair, Inc. Law Department - M1 557

20100184148 - In vitro germinal centers: The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100184149 - method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process: A method for improving productivity in microbial fermentations and mammalian cell culture bioreactors.... Agent: Roberts Mlotkowski Safran & Cole, P.C. Intellectual Property Department

20100184151 - Method for the production of glucose from lignocellulosic feedstocks: A method for producing glucose from a lignocellulosic feedstock is provided. The method comprises pretreating the lignocellulosic feedstock with acid to produce a pretreated feedstock composition. A calcium-containing stream is provided that comprises calcium that is obtained from the lignocellulosic feedstock and a calcium carbonate-containing stream is obtained by precipitation... Agent: Fitzpatrick Cella Harper & Scinto

20100184150 - Nutritional compositions: The present invention is directed to a novel saccharide composition isolated from a yeast culture. The invention is also directed to yeast cell based saccharide composition with increased water-solubility. The saccharide compositions disclosed in the invention can be used as nutritional or pharmaceutical additives or as part of nutritional or... Agent: Brooks Kushman P.C.

20100184153 - High multiplex nucleic acid amplification: This invention relates to the amplification of multiple nucleic acid target sequences. Forward and reverse compound primers comprising a common amplification sequence and a target-specific primer sequence are immobilised at a site on a solid support. Target regions of single-stranded template DNA are primed and copied by the forward primer... Agent: Goodwin Procter LLP Patent Administrator

20100184155 - Method for reducing dispersion in nucleic acid amplification reaction: It is an object of the present invention to provide a method for amplifying a nucleic acid, which does not require complicated temperature control and which can be carried out without using special enzyme or special primers. The present invention provides a method for amplifying a nucleic acid, which comprises... Agent: Birch Stewart Kolasch & Birch

20100184154 - Method for replicating nucleic acid sequence: It is an object of the present invention to provide a method for replicating a nucleic acid sequence using oligonucleotide primers and DNA polymerase. The present invention provides a method for replicating a nucleic acid sequence, which comprises synthesizing a complementary strand with a polymerase that catalyzes a strand displacement... Agent: Birch Stewart Kolasch & Birch

20100184156 - Recombinant colwellia psychrerythraea alkaline phosphatase and uses thereof: A heat labile alkaline phosphatase enzyme and methods of using the same and kits including the same are disclosed. Specifically, a nucleotide sequence of, peptide sequence of, methods of using, and kits comprising, a heat labile alkaline phosphatase isolated from Colwellia psychrerythraea are provided. Methods of over-expression and purification of... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20100184152 - Target-oriented whole genome amplification of nucleic acids: Disclosed herein are methods of amplifying target nucleic acid sequences (e.g., DNA or RNA), particularly from a very small amount of starting material, such as a single cell. These methods involve targeting the amplification of specific sequence(s) by use of sequence-specific primers and random primers for whole genome amplification using... Agent: Klarquist Sparkman, LLP

20100184158 - Dna plasmids with improved copy number: The present invention relates to the production of covalently closed circular (ccc) recombinant DNA molecules such as plasmids, cosmids, bacterial artificial chromosomes (BACs), bacteriophages, viral vectors and hybrids thereof, and more particularly to vector modifications that improve production yield of said DNA molecules in fermentation culture.... Agent: J.k. Weatherspoon & Associates, LLC

20100184157 - E. coli plasmid dna production: General methods and strains of bacteria are described, that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin mediated plasmid extraction combined with flocculation mediated removal of cell debris and host nucleic acids achieves increased yield and purity with simplified downstream purification and reduced waste streams, thus... Agent: Brooks Kushman P.C.

20100184159 - Compositions, methods, and kits for selective amplification of nucleic acids: The current teachings are directed to compositions, methods, and kits for selectively amplifying and for detecting target sequences. In some embodiments, a circularizable probe and/or a probe pair are disclosed for selectively amplifying target sequences. Methods for selectively amplifying target sequences are also disclosed, as are methods for detecting selectively... Agent: Life Technologies Corporation C/o Intellevate

20100184161 - Acidothermus celluloyticus xylanase: A thermophilic endo-beta-1,4-xylanase derived from Acidothermus cellulolyticus is disclosed. The xylanase exhibits xylanase activity at an optimal temperature of 90° C. and an optimal pH range of about 4.5-6.0. The isolated xylanase is useful in the hydrolysis of lignocellulosic material.... Agent: Morrison & Foerster LLP

20100184160 - Staphylococus aureus strain cyl1892: This disclosure presents embodiments of novel strains of Staphylococcus aureus that through genetic engineering produce type 5 capsular polysaccharide at greater levels than Staphylococcus aureus strain Reynolds.... Agent: Polsinelli Shughart PC

20100184162 - Method for production of an l-amino acid: A method is provided for producing an L-amino acid by culturing a microorganism belonging to the Enterobacteriaceae family and having the ability to produce an L-amino acid, in a medium to produce and accumulate the L-amino acid in the medium. The microorganism has been modified by introduction of a DNA... Agent: Cermak Nakajima LLP Acs LLC

20100184163 - Method for production of l-glutamine: A polypeptide comprising an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence of a glutamine synthetase 2 derived from a microorganism belonging to a coryneform bacterium, wherein the coryneform bacterium producing the polypeptide has L-glutamine productivity, a DNA... Agent: Fitzpatrick Cella Harper & Scinto

20100184164 - Microorganism producing l-methionine precursor and method of producing l-methionine and organic acid from the l-methionine precursor: The present invention relates to a method for producing L-methionine and organic acid comprising the following steps: Step 1) preparing a strain producing L-methionine precursor and producing L-methionine precursor by the fermentation of the strain; Step 2) producing L-methionine and organic acid by the enzyme reaction process with the L-methionine... Agent: Swanson & Bratschun, L.L.C.

20100184165 - Novel aldolase, and method for producing optically active ihog and monatin: The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100184166 - Method for producing alkaloids: The present invention provides a method for producing an alkaloid, for example, reticuline, comprising providing dopamine as a substrate for a series of actions of monoamine oxidase, norcoclaurine-6-O-methyltransferase, coclaurine-N-methyltransferase and 3′-hydroxy-N-methylcoclaurine-4′-O-methyltransferase.... Agent: Birch Stewart Kolasch & Birch

20100184167 - Method for producing purified tea extract: A purified tea extract is improved in taste by reducing a percentage of gallates in the non-polymer catechins. A process according to the present invention for the production of a purified tea extract includes subjecting a tea extract to a hydrolysis treatment, causing the tea extract to adsorb on the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100184169 - Modified photosynthetic microorganisms with reduced glycogen and their use in producing carbon-based products: This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more mutations or deletions in a glycogen biosynthesis or storage pathway, which accumulate a reduced amount of glycogen as compared to a wild type Cyanobacterium, and which are capable of producing an increased amount of lipids and/or... Agent: Seed Intellectual Property Law Group PLLC

20100184168 - Process for producing fatty acids: A process for producing fatty acid by hydrolyzing oil and fat, which comprises: a first step of partially hydrolyzing oil and fat by either of the following method (a) or (b), and a second step of hydrolysis by the other method: (a) enzymatic hydrolysis using an immobilized enzyme which is... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100184170 - Development of a fermentative enrichment culture and two pure isolates that biotransform high concentrations of chloroform and other halomethanes: Disclosed are fermentative enrichment cultures and two pure isolates there from for use in biotransformation of halomethanes. Disclosed bioaugmentation cultures are dominated by Enterobacteriaceae, and are implemented together with one or more electron donors such as corn syrup, glucose, and the like, and a corrinoid catalyst such as vitamin B12.... Agent: Dority & Manning, P.A.

20100184171 - Materials and methods for efficient succinate and malate production: Genetically engineered microorganisms have been constructed to produce succinate and malate in mineral salt media in pH-controlled batch fermentations without the addition of plasmids or foreign genes. The subject invention also provides methods of producing succinate and malate comprising the culture of genetically modified microorganisms.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100184172 - System for the production of aromatic molecules in streptomyces: A process for the production of natural ferulic acid, coniferyl alcohol and/or vanillin, includes the bio-conversion of eugenol by a bacteria belonging to the Streptomyces genes including at least one nucleotide sequence SEQ ID NO:1 or SEQ ID NO:8 or any nucleotide sequence having at least 70%, preferably 80% and... Agent: Young & Thompson

20100184173 - Microorganisms for the production of methyl ethyl ketone and 2-butanol: A non-naturally occurring microbial organism having a methyl ethyl ketone pathway includes at least one exogenous nucleic acid encoding a methyl ethyl ketone pathway enzyme expressed in a sufficient amount to produce methyl ethyl ketone. The methyl ethyl ketone pathway includes a β-ketothiolase, a β-ketovalerate decarboxylase and an enzyme selected... Agent: Mcdermott, Will & Emery

20100184174 - Process for the oxidative cleavage of vinylaromatics using peroxidases or laccases: wherein n is an integer of 0 to 5; the R1 are selected from saturated or unsaturated hydrocarbon groups with 1 to 10 carbon atoms, wherein carbon atoms are optionally substituted by heteroatoms and are optionally further substituted, amino, C1-6 alkylamino and C1-6 dialkylamino groups, halogens, hydroxy and cyano, wherein... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100184175 - Bgl6 beta-glucosidase and nucleic acids encoding the same: The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding BGL6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL6, recombinant BGL6 proteins and methods for producing the same.... Agent: Genecor International, Inc

20100184176 - Biomass hydrothermal decomposition apparatus, method thereof, and organic material production system using biomass material: A biomass hydrothermal decomposition apparatus includes, a biomass feeder (31) that feeds biomass material (11) under normal pressure to under increased pressure, a hydrothermal decomposition device (42A) that allows the fed biomass material (11) to be gradually moved inside a device main body (42A) from either end thereof in a... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100184177 - Plastic disposable reactor system: A plastic, disposable reactor (“PDR”) system is presented that will allow growth of microorganisms at various temperatures and pressures cost effectively. In this invention, the use of the system for aquaculture of algae is presented. The use of the reactor will allow carbon sequestration and significant production of a renewable... Agent: Emerson, Thomson & Bennett, LLC

20100184178 - Increased isoprene production using mevalonate kinase and isoprene synthase: The invention features methods for producing isoprene from cultured cells having increased expression levels and/or activity levels of a mevalonate kinase polypeptide and an isoprene synthase polypeptide. The invention also provides methods for producing isoprene from cultured cells having reduced accumulation of intermediates (such as mevalonate, isopentenyl diphosphate, 3,3-dimethylallyl diphosphate,... Agent: Morrison & Foerster LLP

20100184179 - Microbial-mediated method for metal oxide nanoparticle formation: The invention is directed to a method for producing metal oxide nanoparticles, the method comprising: (i) subjecting a combination of reaction components to conditions conducive to microbial-mediated formation of metal oxide nanoparticles, wherein said combination of reaction components comprise: metal-reducing microbes, a culture medium suitable for sustaining said metal-reducing microbes,... Agent: Scully Scott Murphy & Presser PC

20100184180 - System, method, and device for the expression or repression of proteins: This invention relates to systems, methods, and devices for inducing and/or repressing the expression of proteins. More particularly, the invention relates to systems, methods, and devices for inducing and/or repressing the expression of proteins in plastids. An exemplary embodiment involves the regulation of the expression of proteins involved in hydrogen... Agent: Barnes & Thornburg LLP

20100184181 - Genetic cluster of strains of streptococcus thermophilus having appropriate acidifying and texturizing properties for dairy fermentations: The invention relates to a genetic cluster of strains of Streptococcus thermophilus, which have a lysotype distinct from that of the strains currently used. Within this cluster novel acidifying and texturizing strains have been identified.... Agent: Mcandrews Held & Malloy, Ltd

20100184182 - Method for preparing biological tissue: This invention provides a means for preparing biological tissue within a short period of time. This invention provides a method for preparing biological tissue comprising: adding a culture solution containing cells and an extracellular matrix component that was separately prepared to a culture vessel having an inner bottom surface, which... Agent: Sughrue Mion, PLLC

20100184183 - Collagen scaffold modified by covalent grafting of adhesion molecules, associated methods and use thereof for cardiovascular and thoracic cell therapy and contractile tissue engineering: Materials and methods for improving the biological properties and electromechanical performance of collagen scaffolds used for cell transplantation, including the fixation of biocompatible reagents and adhesion molecules which control cell adhesion, apoptosis, survival and/or differentiation simultaneously. The grafting of adhesion molecules to collagen matrices renders same suitable for use in... Agent: Young & Thompson

20100184184 - Production of conjugates: Disclosed is a method for indirectly coupling a small molecule ligand to a molecule to be labelled with the ligand, the method comprising the step of: contacting a scaffold molecule, to which is attached at least one small molecule ligand, with the molecule to be labelled, the scaffold molecule having... Agent: Morgan Lewis & Bockius LLP

20100184185 - Isolated luciferases and the use thereof: The invention relates to the nucleotide and amino acid sequences, and to the activity and use, of the luciferases LuAL, Lu164, Lu16, Lu39, Lu45, Lu52 and Lu22.... Agent: Edwards Angell Palmer & Dodge LLP

20100184186 - Novel rigidoporus microporus laccase: An isolated R. microporus laccase, a nucleic acid encoding the laccase, and a method of preparing it in a cell.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100184187 - In vitro recombination method: The present invention relates, e.g., to in vitro method, using isolated protein reagents, for joining two double stranded (ds) DNA molecules of interest, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule share a region of sequence identity, comprising contacting the... Agent: Synthetic Genomics C/o Mofo

20100184188 - Alkaline protease: It is an object of the present invention to provide alkaline proteases having industrially sufficient protein productivity and a significant detergency. In the alkaline proteases, the amino acid residues at (a) position 9, (b) position 49, (c) position 194, (d) position 212, (e) position 237, (f) position 245, (g) position... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100184189 - Protein for the chemoenzymatic production of l-threo-hydroxyaspartate: A simple mutant of the natural asparagine oxygenase comprises at least the amino acids 13 to 318 of the natural asparagine oxygenase AsnO. In this protein according to the present invention, comprising at least the amino acids 13-318 of AsnO D241N, the amino acid residue at position 241 of the... Agent: Clark & Brody

20100184192 - Avian influenza chimeric vlps: This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs... Agent: Cooley LLP Attn: Patent Group

20100184190 - Influencing viral lipid constituents: This invention provides compositions, methods and systems to modulate the lipid content and membrane characteristics of cells and virions. Growth of host cells on media containing particular amounts, classes and/or combinations of lipid supplements can influence the lipid content of the cell and viruses grown on the cell. Lipids, such... Agent: Quine Intellectual Property Law Group, P.C.

20100184191 - Novel method for generation of rna virus: The present invention provides a method for generating negative-strand, segmented RNA viruses using linear expression constructs in the presence of helper virus.... Agent: Michael Fedrick

20100184193 - Overexpression of aminoacyl-trna synthetases for efficient production of engineered proteins containing amino acid analogues: Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine.... Agent: Seed Intellectual Property Law Group PLLC

20100184194 - Golden yellow algae and method of producing the same: The present invention relates to a method for cultivating carotenoid rich golden yellow algae by varying the ratio of carbon to nitrogen content in the culture medium during cultivation and supplementing the media periodically with citrate and acetate compounds to enhance the carotenoid production and produce change in the colour... Agent: Townsend And Townsend And Crew, LLP

20100184195 - Recycling system for manipulation of intracellular nadh availability: The present invention describes a novel recombinant NADH recycling system that is used as a process for producing reduced compounds. In a specific embodiment, the reduced compounds include ethanol, succinate, lactate, a vitamin, a pharmaceutical and a biodegraded organic molecule. The NADH recycling system effects metabolic flux of reductive pathways... Agent: Baker & Mckenzie LLP

20100184196 - Composite yeast suitable for high concentration alcohol fermentation from sugar-containing raw materials: The present invention relates to a composite yeast suitable for high concentration alcohol fermentation from sugar-containing raw materials, characterizing in that the composite yeast comprises any kind of dried yeast selected from Brewers yeast Saccharomyces cerevisiae Hansen of Saccharomyces cerevisiae, grape wine yeast Saccharomyces uvarum Beijerinek, and nutritious materials which... Agent: Clark & Elbing LLP

20100184197 - Methods for harvesting biological materials using membrane filters: The present disclosure relates to methods for harvesting biological materials, such as, for example, microalgal cells, using membrane filters, such as ceramic-based membrane filters.... Agent: Corning Incorporated

20100184198 - Systems and methods of urea processing to reduce sorbent load: The present invention provides novel methods for removal and disposal of ammonia from spent dialysate in a dialysis system. Ammonium ions present in spent dialysate are converted into gaseous ammonia by raising the pH of the spent dialysate solution in a first reactor. Gaseous ammonia diffuses through a semi-permeable hydrophobic... Agent: Patentmetrix

20100184199 - Well plate reactor: A well plate and its supporting devices provide capabilities found in larger fermenters, such as controlling the oxygen level, the pH level, and temperature of the contents of the well. The well plate includes a plurality of wells, each of which can be independently controlled. Apertures in the wells, for... Agent: Silicon Valley Patent Group LLP

20100184200 - Cell culture device: The present invention relates to a cell culture device which includes: a cell culture container comprising a container body and a neck connecting to the container body wherein the container contains a top wall, a bottom wall having a first opening, and at least one side wall to define a... Agent: Bacon & Thomas, PLLC

20100184201 - Measuring unit for measuring characteristics of a sample liquid, in particular viscoelastic characteristics of a blood sample: The present invention is directed to a measuring unit, for measuring characteristics of a sample liquid, comprising a support member, having at least one upper bearing arm, with an upper bearing unit, at least one lower bearing arm, with a lower bearing unit, and a base, for being attachable to... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20100184202 - Thermal reaction device and method for using the same: An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming... Agent: Townsend And Townsend And Crew, LLP

20100184203 - Straw equipped with a plug comprising a filtering element: This is a straw that comprises a tube (11) equipped with a plug (12) comprising a filtering element that is apart of the end (16) of the plug facing towards the end (15) of the tube furthest from the plug. Such a straw is used for storing a predetermined dose... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100184208 - Htert gene expression regulatory gene: Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase... Agent: Pearne & Gordon LLP

20100184207 - Methods for producing interfering rna molecules in mammalian cells and therapeutic uses for such molecules: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100184204 - Novel glyphosate-n-acetyltransferase (gat) genes: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds,... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20100184205 - Nucleic acids involved in viral infection: Provided herein are isolated viral and human nucleic acids associated with viral infection and various nucleic acid molecules relating thereto or derived therefrom. The nucleic acids may be useful for the prevention, treatment and diagnosis of viral infections.... Agent: Rosetta-genomics C/o Polsinelli Shughart PC

20100184206 - Targeting pseudotyped retroviral vectors: The present invention relates to retroviral vectors, particularly lentiviral vectors, pseudotyped with Sindbis envelope and targeted to specific cell types via a targeting moiety linked to the envelope.... Agent: Townsend And Townsend And Crew, LLP

20100184209 - Compositions and methods for inhibiting gene silencing by rna interference: The present invention provides compositions and methods for inhibiting gene silencing by the RNAi pathway. The RNAi inhibitors of the invention have a reverse complement (RC) region to the target molecule of interest (e.g., miRNA) in association with at least one flanking region coupled to either at the 3′ or... Agent: Merchant & Gould PC

20100184210 - Method for isolating cells: e

20100184211 - Tumour-associated peptides that bind to mhc molecules: The invention relates to a tumor-associated peptide containing an amino sequence, which is selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:79 of the enclosed listing. The peptide has the ability to bind to a molecule of the human major histocompatibility complex (MHC) class-I. The invention... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100184213 - Apocrine cell line: An apocrine cell line is obtained by the steps of isolating an apocrine cell from primary tissue, culturing the isolated cell in a first culture medium, removing unattached cells from the first culture medium and transferring said unattached cells to a second culture medium comprising an effective concentration of a... Agent: Unilever Patent Group

20100184212 - Human embryonic stem cell derived mesoderm-like epithelium transitions to mesenchymal progenitor cells: Human embryonic stem cells (hESC) have the potential to produce all of the cells in the body. They are also able to self-renew indefinitely, sparking the hope they could be used as a source for large scale production of therapeutic cell lines. The present invention relates to a monolayer differentiation... Agent: Coleman Sudol Sapone, P.C.

20100184214 - Method for production of dendritic cell: The present invention provides methods for producing DCs, which comprise the step of culturing DC precursor cells in the presence of multiple cytokines, dendritic cells produced thereby, and uses thereof. The methods of the present invention enable production of large quantities of DC precursors with a high ability to differentiate... Agent: Clark & Elbing LLP

20100184216 - Htert gene expression regulatory gene: Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase... Agent: Pearne & Gordon LLP

20100184215 - Modified thioredoxin: The present invention relates to a human modified thioredoxin composed of any of the following polypeptides: (a) a polypeptide modified by alteration or chemical modification of a cysteine residue at position 35 with another amino acid in an amino acid sequence of SEQ ID NO:2; and (b) a polypeptide having... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100184218 - Isolation and culture-expansion methods of mesenchymal stem/progenitor cells from umbilical cord blood, and differentiation method of umbilical cord blood-derived meschymal stem/progenitor cells into various mesenchymal tissues: There is provided a method for the isolation and cultivation of mesenchymal stem/progenitor cells from umbilical cord blood, and also to a method for the differentiation of the umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues. The method include overlaying umbilical cord blood onto Ficoll-Hypaque solution; centrifuging the... Agent: Sughrue Mion, PLLC

20100184217 - Stem cell lines, their application and culture methods: New lines of stem cells from the growing antlers of deer (Cervidae) and the application of said cells in the reconstruction of connective tissue, preferentially bone, cartilage or adipose tissue, in humans and animals; as well as a method of culturing them and the application of tissues from growing deer... Agent: Cooper & Dunham, LLP

20100184219 - Methods and apparatuses relating to cell culture media: A method of preparing cell culture media for use in culturing cells and an apparatus for carrying out the method. The method includes providing a vessel containing cell culture media and exposing the cell culture media to a first controlled atmosphere having a predetermined O2 concentration that is less than... Agent: Swanson & Bratschun, L.L.C.

20100184221 - Method for isolation of cell, serum-free culture medium for cell, and method for culture of cell: The present invention provides a method for isolating cells, in particular, stem cells, which method comprises the steps of: dissociating cells from a tissue of animal origin; seeding and incubating the cells in a culture vessel with no surface treatment; and selecting cells adhered to the vessel.... Agent: Leydig Voit & Mayer, Ltd

20100184222 - Method for preparing biological tissue: This invention provides a method for preparing biological tissue in which the thickness (i.e., the number of cell layers) can be easily regulated, culture can be conducted within a shorter period of time than is possible with conventional techniques, and addition of unfavorable components is not necessary. The method of... Agent: Sughrue Mion, PLLC

20100184220 - Prevascularized tissue transplant constructs for the reconstruction of a human or animal organ: i

20100184223 - Biomaterial based on a hydrophilic polymeric carrier: The present invention relates to a biomaterial for cell or tissue culture, based on a polymeric carrier, which contains at least one crosslinkable hydrophilic polymer. The polymer is functionalized with groups that are selected from maleimide, vinylsulfonic, acrylate, alkyl halide, azirine, pyridyl, thionitrobenzene acid groups, or arylating groups. The invention... Agent: Morrison & Foerster LLP

20100184224 - Plant cell wall loosening activity of group 2/3 allergens of grass pollen: The present invention provides nucleic acids and polypeptide sequences for a novel class of expansin-related proteins, designated group 2/3 allergen, which comprise the group 2 and group 3 allergens from grass, a purified group 3 allergen Lol p 3, and method of using the nucleic acids sequences and proteins of... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pennsylvania State University

20100184226 - Media conditioning for improving gene delivery efficiency to differentiating embryonic stem cells: The present invention provides systems and methods for improving the efficiency of a transient gene delivery system to differentiating embryonic stem (ES) cells by serum starving the targeted cells for one to three days prior to transfection. Such a serum starvation surprisingly resulted in increased expression of a constitutively-controlled plasmid... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20100184227 - Pluripotent stem cells obtained by non-viral reprogramming: Methods for reprogramming primate somatic cells to pluripotency using an episomal vector that does not encode an infectious virus are disclosed. Pluripotent cells produced in the methods are also disclosed.... Agent: Quarles & Brady LLP

20100184225 - Use of a cellular extract for a mitotic remodeling of chromosomes: The present invention relates to the use of a female germinal cell (egg) extract of pluricellular organisms in M-phase of the cell cycle for a mitotic remodeling of chromosomes of donor cells of pluricellular organisms, wherein the mitotic remodeling confers to the nucleus of the donor cells the ability to... Agent: Young & Thompson

  
07/15/2010 > patent applications in patent subcategories. category listing

20100178647 - Simulation of normal fresh blood platelets: The present invention provides for novel analogs of fresh human platelets for use in hematological instrument. Methods for preparing such analogs are also described.... Agent: Townsend And Townsend And Crew, LLP

20100178648 - In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate or nanoparticulate active agent compositions: Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions.... Agent: Elan Drug Delivery, Inc. C/o Foley & Lardner

20100178651 - Bifunctional predictors of cancer treatment sensitivity and resistance: The present invention provides the identification of genes that are expressed in tumors to indicate responsiveness or resistance to an agent or class of agents. More particularly, these genes show expression associated with responsiveness to one agent or class of agents is inversely related to expression in association with another... Agent: Baker Botts L.l.p

20100178650 - Capillary-based cell and tissue acquisition system (ctas): The present invention relates to a capillary-based cell and tissue acquisition system that integrates the capillary approach with a microscope manipulator to collect and sort cells of interest. Cells of interest are determined by using a laser beam focus to identify the initial contact between the capillary and the cells.... Agent: Gates & Cooper LLP Howard Hughes Center

20100178653 - Gene expression signature for classification of cancers: The present invention provides a process for classification of cancers and tissues of origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA tree-based expression framework allows optimization of treatment, and determination of specific therapy.... Agent: Foley And Lardner LLP Suite 500

20100178649 - Genomics-based quality diagnostics for prediction of cold-sweetenng during storage in processing potato: The invention relates to the field of quality testing of fresh potato products. Methods, carriers and kits for determining and/or predicting the quality stage of potato batches are provided.... Agent: Foley And Lardner LLP Suite 500

20100178652 - Materials and methods for the detection, prevention and treatment of autoimmune disease: The subject invention provides materials and methods for the detection, prevention, and treatment of diabetes and other autoimmune conditions.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100178654 - Reagent and reagent kit for analysis of immature leukocyte: e

20100178655 - Single-cell nucleic acid analysis: The present invention provides methods for analysis of genomic DNA and/or RNA from small samples or even single cells. Methods for analyzing genomic DNA can entail whole genome amplification (WGA), followed by preamplification and amplification of selected target nucleic acids. Methods for analyzing RNA can entail reverse transcription of the... Agent: Weaver Austin Villeneuve & Sampson LLP

20100178656 - Multiple analysis of blood samples: The invention relates to a method for detecting a plurality of antigenic molecules carried by erythrocytes and/or a plurality of anti-erythrocyte antibodies of an individual, comprising bringing a sample into contact with distinguishable beads, on which are attached a) antibodies specific for said antigens, or b) erythrocytes, erythrocyte membrane fragments... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100178658 - Screening assays for inhibitors of beta amyloid peptide ion channel formation: Screening assays and methods of employing the screening assays designed to identify potential inhibitors of amyloidal neurodegenerative disease. The screening assays comprises providing a membrane construct disposed on a substrate and contacting the membrane construct with Aβ peptide capable of forming an Aβ peptide ion channel in the construct. The... Agent: Harness, Dickey & Pierce, P.L.C

20100178657 - Molecular assembly on a substrate: The present invention relates to a molecular assembly on a substrate usable for studying and/or performing biological interactions and/or reactions The invention further relates to an in vitro method to provide a substrate with a heparin coating presenting biotinylated biomolecules comprising linking avidin to a surface capable of binding avidin.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100178659 - Method of measuring hba1c: A method of measuring HbA1c is provided that, even with a whole blood sample after storage, measurement accuracy substantially equal to a whole blood sample right after collection can be maintained. Whole blood is stored in a presence of a glycolytic inhibitor and protease is added to the stored whole... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100178663 - Apparatus and methods for the detection of plasma metanephrines: Embodiments of the present invention feature the determination of normetanephrine, metanephrine and 3-methoxytyraminein raw human plasma with minimal sample pretreatment using a weak cationic extraction media to provide a selective sample clean-up and HILIC chemistries as indicators of pheochromoacytoma.... Agent: Waters Technologies Corporation

20100178661 - Automatic tissue microarray apparatus and method for arraying tissue using the same: Disclosed is an automatic tissue microarray apparatus that includes: a sample module being drivable and providing a space for mounting at least one donor block and at least one recipient block; an extract module being drivable in at least two directions and having at least one punching tip for punching... Agent: Holme Roberts & Owen LLP

20100178660 - Methods and kits for detecting hemoglobin in test samples: The present invention relates to methods of detecting hemoglobin in a test sample. These methods can be used to diagnose a subject suffering from a genetic disorder relating to hemoglobin metabolism, to determine the eligibility of a subject to be a blood donor, to determine the age of a stored... Agent: Paul D. Yasger Abbott Laboratories

20100178665 - Monitoring and manipulating cellular transmembrane potentials using nanostructures: The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed. Nanoparticles having phospholipid coatings were found to display improved responses relative to nanoparticles having other coatings that do not promote localization or attraction to membranes.... Agent: Life Technologies Corporation C/o Intellevate

20100178662 - Non-invasive human-health-measurement system and method: Methods and hand-held devices non-invasively measure a health parameter in an individual or a plurality of individuals. Plural hand-held devices may be provided to plural individuals. Each device may compute a score based on the assayed health parameter in the individual. A server on a computer network may receive the... Agent: Klarquist Sparkman, LLP

20100178664 - Optical measurement method for determining the ph of a medium using ageladine a as a fluorescent ph indicator: An optical measurement method for determining a pH of a medium includes adding a fluorescent pH indicator to the medium. The pH indicator is based on naturally-obtained or synthesized ageladine A. The pH indicator is irradiated with light of at least one wavelength so as to provide fluorescence excitation of... Agent: Leydig, Voit And Mayer

20100178666 - Systems and methods for focusing particles: Provided is a method of focusing particles. The method includes: providing a suspension of the particles in a suspending medium; and flowing the suspension along a channel, such that the flowing suspension occupies a certain volume that has at least one cross-sectional dimension smaller than 100 μm. The suspending medium... Agent: Fennemore Craig

20100178667 - Periodic acid-schiff staining with detection in the infrared range: Provided is a method of detecting the presence and quantitating the amount of glycogen from a biological sample. This method employs PAS staining with detection in the infrared range.... Agent: Hoffmann & Baron, LLP

20100178668 - Biological reaction apparatus with draining mechanism: A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region, wherein the apparatus includes a locating means to locate the substrate; a... Agent: Sughrue Mion, PLLC

20100178669 - Method for the intensive extraction of cellular compounds from micro-organisms by continuous culture and extraction, and corresponding device: HA method is provided for extracting cellular compounds from micro-organisms. The method includes culturing the micro-organisms and extracting the cellular compounds from the micro-organisms. Each step is carried out in a continuous manner, wherein the extraction step is carried out separately from the culture step and in conditions of biocompatibility... Agent: Westman Champlin & Kelly, P.A.

20100178670 - Processes of producing fermentation products: The invention relates to a process of fermenting material derived from lignocellulose-containing material into a fermentation product by fermenting said material derived from lignocellulose-containing material using a fermenting organism obtained from a process of fermenting starch-containing material.... Agent: Novozymes North America, Inc.

20100178672 - Cho cell: The current invention comprises a CHO cell which is expressing a constitutively active mitogenic receptor, a method of obtaining such a CHO cell, and a method for the expression of a heterologous polypeptide using a CHO cell according to the invention.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100178671 - Vector constructs and methods for expressing and secreting polypeptides in filamentous fungi using a self-processing 2a cleavage site: e

20100178673 - Methods of gene amplification and expression: Disclosed are methods relating to amplification and expression of a nucleic acid sequence encoding a polypeptide of interest in recombinant cells, and cell lines and polypeptides produced from such methods. The methods disclosed herein permit the amplification of cell lines that express a polypeptide of interest in a relatively short... Agent: Baker Botts L.L.P.

20100178676 - Methods for antibody production: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100178674 - Recovery and purification of b-phycoerythrin produced by porphyridium cruentum using two-aqueous-phase systems and isoelectric precipitation: This invention focuses on a novel process in which Porphyridium cruentum biomass first undergoes a stage of cellular disruption and subsequently stages of recovery and purification in order to achieve the purified B-phycoerythin (BFE) protein dye, using isoelectric precipitation and two-aqueous-phase systems. The steps of recovery and purification include isoelectric... Agent: Baker & Mckenzie LLP

20100178675 - System for extracting protein from a fermentation product: A method of producing bioproducts from a feedstock in a system configured to produce ethanol and distillers grains from a fermentation product is disclosed. A system configured to process feedstock into a fermentation product and bioproducts including ethanol and meal is disclosed. A bioproduct produced from a fermentation product produced... Agent: Turocy & Watson, LLP

20100178677 - System and process for biomass treatment: A system including an apparatus is presented for treatment of biomass that allows successful biomass treatment at a high solids dry weight of biomass in the biomass mixture. The design of the system provides extensive distribution of a reactant by spreading the reactant over the biomass as the reactant is... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100178678 - Method for producing cyclopent-4-ene-1,3-diol or cyclopent-4-ene-1,3-diol derivatives: The invention relates to a method for producing cis-cyclopent-4-ene-1,3-diol and cis-cyclopent-4-ene-1,3-dialkanoates by selective cis-1,2-reduction of 4-hydroxycyclopent-2-enone by means of a hydroboron, in the presence of substoichiometric quantities of a trivalent rare earth metal compound, to form cyclopent-4-ene-1,3-diol which can then be optionally reacted with an acylation agent to form cis-cyclopent-4-ene-1,3-dialkanoates,... Agent: Propat, L.L.C.

20100178679 - Production of isoprenoids: The present invention provides methods for a robust production of isoprenoids utilizing the DXP biosynthetic path-way. The invention also provides nucleic acids, enzymes, expression vectors, and genetically modified host cells for carrying out the subject methods.... Agent: Sheridan Ross PC

20100178680 - Rotatable perfused time varying electromagnetic force bioreactor and method of using the same: A rotatable perfused time varying electromagnetic force bioreactor with a rotatable perfusable culture chamber and a time varying electromagnetic force source operatively connected to the rotatable perfusable culture chamber. In use, the rotatable perfused time varying electromagnetic force bioreactor supplies a time varying electromagnetic force to the rotatable perfusable culture... Agent: Ladas & Parry LLP

20100178682 - Flow cytometer having cell-sorting function and method of separating living cells: A liquid sample flow containing living cells is irradiated with measurement laser light and the photo data of at least either scattering light or fluorescence that is generated by each of the living cells in the liquid sample flow due to the irradiation with the measurement laser light is acquired.... Agent: GlobalIPCounselors, LLP

20100178681 - Lipid-free scaffolds for human volume replacement or cell culture and use thereof: The present invention relates to lipid removed scaffolds(lipid-free scaffolds) for human tissue volume replacement or cell culture. More particularly, the present invention relates to a method for preparing lipid removed scaffolds(lipid-free scaffolds) for human tissue volume replacement or cell culture, the method comprising the steps of: fragmenting fat tissue to... Agent: Edwards Angell Palmer & Dodge LLP

20100178683 - Hair follicle graft from tissue engineered skin: The present invention provides a hair graft comprising (a) tissue engineered skin comprising a tissue engineered epidermal layer, a tissue engineered dermal layer, and hair follicle progenitor cells and (b) a scaffold. The invention also provides methods of making and using the hair grafts of the present invention.... Agent: Pabst Patent Group LLP

20100178684 - Transgenic oncolytic viruses and uses thereof: The present disclosure relates to a recombinant oncolytic virus useful for inhibiting the growth of or killing tumor cells. More specifically, the recombinant oncolytic virus contains a heterologous nucleic acid sequence encoding an inflammation suppressive gene including, but not limited to, natural killer cell inhibitor, a chemokine binding protein, and... Agent: Darby & Darby P.C.

20100178685 - Method and device for aeration, particularly for microbiological fermentation and for cell cultivation: The invention relates to a method and a device for aeration, particularly for microbiological fermentation and for cell cultivation in a closed chamber. The invention comprises a sterilizable reactor (1) and a vertical stirring shaft (2) with numerous aeration and/or stirring elements (10) which are attached thereto and arranged in... Agent: Brian Roffe, Esq

20100178686 - Method and apparatus for providing a photobioreactor: The present invention provides for a photobioreactor for the cultivation of photosynthetic microorganisms and comprises a hydraulic circuit through which an aqueous solution containing culture of at least one type of photosynthetic organism circulates and gets exposed to a light source. The photobioreactor also comprises a means for feeding carbon... Agent: Law Offices Of Daniel L. Dawes Dawes Patent Law Group

20100178687 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: Searete LLC Clarence T. Tegreene

20100178688 - Acoustic wave biosensor for the detection and identification of characteristic signaling molecules in a biological medium: An acoustic wave biosensor comprises a plurality of spaced apart electrodes disposed on a substrate of piezoelectric material and having a biolayer matched to a specific type of autoinducer signaling molecule to be detected. The biolayer comprises a layer of heterobifunctional molecules disposed on the electrodes and on the piezoelectric... Agent: Carey, Rodriguez, Greenberg & Paul LLP Attn: Steven M. Greenberg, Esq.

20100178689 - Device for decantation deposition of cells on an analysis plate: A device includes a reception chamber (5) for a cell suspension having an open bottom (6) extending opposite a cell deposition area (7) of the analysis plate (1), the bottom (6) of the chamber (5) being in fluid communication with an absorption material (14) for cell preservation liquid for absorbing... Agent: Young & Thompson

20100178690 - Biomolecule detection apparatus and biomolecule measurement system: According to the present invention, a biomolecule detection apparatus that achieves excellent performance in the detection of rare cells and has a biochip structure to ensure quality mass production, and a biomolecule measurement system that can accurately and easily measure the biomolecules captured by the biomolecule detection apparatus can be... Agent: Mcdermott Will & Emery LLP

20100178691 - Systems, methods, and apparatus for single molecule sequencing: An embodiment generally relates to a system for analysis of an analyte. The system can include a transparent substrate. The system also includes an excitation light source configured to induce an evanescent wave excitation of a fluorescently labeled molecule near the access to the transparent substrate and a detector for... Agent: Life Technologies Corporation C/o Intellevate

20100178692 - Model cell chip, apparatus for evaluating drug effect using the model cell chip and method of evaluating drug effect: A pulsating cell population and hERG-expressing cells (target model cells) are suitably isolated and arranged on a transparent substrate so that the two form gap junctions. The hERG-expressing cells are arranged on transparent electrodes provided on the transparent substrate. The hERG-expressing cells are exposed to a flow of a liquid... Agent: Sughrue Mion, PLLC

20100178693 - Gas decomposing apparatus: A gas cracking apparatus adapted to simultaneously efficiently discharge gas heavier than air and gas lighter than air resulting from assimilations of malodorous gas and greenhouse gas. The main frame of the gas cracking apparatus includes a closed metallic circular tube or angular tube. This tube is provided at its... Agent: Rader Fishman & Grauer PLLC

20100178694 - Cell culture module: A cell culture module includes a sealing member 10 sealably holding in an inner space 12 a cell culture carrier S made up of a porous body having a concave portion S1 for culturing cells; a water pressure supplying portion 20 supplying a water pressure onto a second surface Sb... Agent: Foley And Lardner LLP Suite 500

20100178695 - Specimen preparation apparatus, specimen preparation/analysis system and specimen plate: Provided is a specimen preparation apparatus capable of supplying a specimen from the specimen preparation apparatus to a specimen analyzer without burdening an operator. This specimen preparation apparatus comprises a stained specimen preparation part for preparing a specimen on a slide glass and staining the specimen, a keeping part for... Agent: Brinks Hofer Gilson & Lione

20100178696 - In vivo genome-wide mutagenesis: Disclosed herein are compositions and methods for deleting or duplicating DNA in a mammalian genome. Also disclosed are compositions and methods for generating a random genome-wide chromosome rearrangement. Also disclosed are compositions and methods for streamlined construction of gene targeting vectors.... Agent: Ballard Spahr LLP

20100178697 - System, apparatus and method for material preparation and/or handling: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along... Agent: Seed Intellectual Property Law Group PLLC

20100178698 - Tissue culture device: A tissue culture device includes a container having one or more upstanding walls extending upwardly from a floor. The floor of the container has a media having nutrients or growth substances therein. A plurality of plant tissues are within the container compartment and are placed upon a screen between the... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pioneer Hi-bred

20100178699 - Multi-chain lipophilic polyamines: There are provided multi-chain lipophilic polyamine compounds and derivatives thereof, pharmaceutical formulations comprising the same, method of making and using said compounds or formulations.... Agent: Foley And Lardner LLP Suite 500

20100178700 - Novel thymic cellular populations and uses thereof: The present invention relates generally to novel thymic cellular populations and, more particularly, to novel thymic epithelial cellular populations. Most particular, the present invention is directed to novel thymic epithelial progenitor cell populations. The cellular populations of the present invention are useful in a wide range of clinical and research... Agent: Knobbe Martens Olson & Bear LLP

20100178701 - Proliferation culture methods using micro-scaffolds for regulations of cell-to-cell signals: The present invention aims to provide a three-dimensional cell culture method for increasing cell proliferation efficiency by suitably regulating the proliferation-inducing and proliferation-inhibitory signals between cells, which are the greatest variables in proliferation efficiency. For this purpose, the present invention provides a method for culturing cells using micro-scaffolds by the... Agent: Park Law Firm

20100178702 - Extracellular vesicles from non-pathogenic amoebae useful as vehicle for transferring a molecule of interest to an eukaryotic cell: The invention relates to membrane vesicles from non-pathogenic amoeba, in particular from the amoeba Dictyostelium discoideum, containing a molecule of therapeutic interest, to a method of preparing such vesicles and to the use of the vesicles as a vehicle for transferring the molecule therapeutic interest to an eukaryotic mammalian cell.... Agent: Young & Thompson

  
07/08/2010 > patent applications in patent subcategories. category listing

20100173277 - Agent for suppressing rejection in organ transplantation comprising anti-hmgb-1 antibody: An objective of the present invention is to provide effective methods for suppressing rejection in organ transplantation, in particular, pancreatic islet transplantation which is useful in treating diabetes. The present invention demonstrated that antibodies against HMGB-1 suppressed the rejection in pancreatic islet transplantation and promoted the survival of grafted pancreatic... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100173278 - Microcapsules containing mammals' spermatozoids, insemination dose containing same and method for obtaining same: The invention particularly relates to microcapsules comprising: a core containing mammals', but not human, spermatozoids in suspension in a diluter, i.e. a liquid medium capable of preserving spermatozoids; an encapsulation matrix made of a polymeric material. The microcapsules are characterised in that said matrix is non-spermicidal and is made of... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20100173279 - Detection using primers to repetitive dna and transcription-based amplification thereby: The present invention concerns identifying organisms based on detecting distinguishing patterns produced following RNA amplification that originates via a DNA template. In particular, the methods and compositions of the invention concern obtaining ds DNA from the organism in question, amplifying at least part of the DNA via RNA molecules from... Agent: Fulbright & Jaworski, LLP

20100173281 - Hcv ns3 protease replicon shuttle vectors: The present invention provides for novel HCV NS3 protease replicon shuttle vectors useful for cloning in HCV polynucleotide sequences from samples of HCV-infected patients and testing the resulting replicons for drug susceptibility.... Agent: Roche Palo Alto LLC Patent Law Dept. M/s A2-250

20100173284 - Method for detection of hcv at the real time pcr with intercalating dye: The present invention relates to a composition for detection of HCV by a single step reaction, comprising a specific primer and probe. In particular, the present invention relates to a composition for detection of HCV by a single step reaction, comprising the primer sequences of SEQ ID NOs:1 and 2;... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100173283 - Method of predicting potential severity of hepatitis e, probe sets, and primer sets: The present invention provides a method of predicting potential severity of hepatitis, includes determining that hepatitis in a subject is potentially severe when it is detected that any amino acid is mutated to an amino acid of genotype-4, the any amino acid being amino acid of an amino acid sequence... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100173282 - Mutational profile in hiv-1 gag cleavage site correlated with phenotypic drug resistance: The invention concerns novel mutations or mutational profiles of HIV-1 protease cleavage sites (CS) in the Gag region correlated with a phenotype causing alterations in sensitivity to anti-HIV drugs. The present invention also relates to the use of genotypic characterization of a target population of HIV and the subsequent association,... Agent: Patton Boggs LLP/ Johnson & Johnson

20100173280 - Systems for detection and production of respiratory, herpes and enteric viruses: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial... Agent: Medlen & Carroll

20100173315 - Assay particles and methods of use: The invention provides assay particles useful, for example, for detecting analytes and binding molecule interactions. One type of assay particle includes a core portion encased by a shell portion, wherein the shell portion comprises an inorganic phosphor that binds selectively to a target molecule. Another type of an assay particle... Agent: Fish & Richardson PC

20100173313 - Biomarkers of inflammation: Methods for the detection of DP2 receptors in biological samples is disclosed. The induction and detection of DP2 receptors expressed on activated human neutrophils is presented. Also presented are diagnostic kits for the detection of DP2 receptors in biological samples.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100173319 - Compositions and methods for cancer diagnosis and therapy: The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate cancer. Chronic lymphocytic leukemia or prostate cancer can be diagnosed by detecting a reduction in miR15 or... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100173305 - Compositions, kits and related methods for the detection and/or monitoring of listeria: Provided are compositions, kits, and methods for the identification of Listeria. In certain aspects and embodiments, the compositions, kits, and methods may provide improvements in relation to specificity, sensitivity, and speed of detection.... Agent: Foley & Lardner LLP

20100173314 - Diagnostic methods using tenascin-w compositions: Tenascin-W. an extracellular matrix molecule that is specifically expressed in metastatic tumours is provided. A system comprising a sample expressing tenascin-W is used as an in vitro method for screening possible anti-tumour agents or for agents that promote osteogenesis.... Agent: Hoxie & Associates LLC

20100173294 - Diagnostic test for susceptibility to b-raf kinase inhibitors: The present invention provides methods and reagents for the detection of a mutation in BRAF and methods of selecting patients for treatment if a B-Raf kinase inhibitor, such as a selective B-Raf kinase inhibitor... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100173295 - Fixation of a biological material: The present invention relates to a method for the treatment of a biological material, comprising the steps i) providing a biological material, and ii) contacting the biological material with a first non-aqueous composition comprising: (a1) 10 to 90 vol. % methanol, and (a2) at least one additional additive, and (a3)... Agent: Seed Intellectual Property Law Group PLLC

20100173312 - Genetic lesion associated with cancer: The invention comprises methods for identifying mutations within the 3′ UTRs of genes that lead to increased risk or probability of developing cancer.... Agent: Mintz Levin Cohn Ferris Glovsky And Popep, P.C.

20100173298 - Hcv gene: The present invention provides a hepatitis C virus gene, a replicon RNA derived from the gene, a replicon-replicating cell into which the replicon RNA is introduced, and a method for screening a drug using the replicon-replicating cell. By introducing a replicon RNA comprising (A) a polynucleotide having the nucleic acid... Agent: Birch Stewart Kolasch & Birch

20100173293 - High density sequence detection methods: A method for performing PCR on a liquid sample comprising a plurality of polynucleotide targets, wherein each polynucleotide target is present at very low concentration within the sample. The method comprises applying PCR reactants to the surface of a substrate to produce a plurality of reaction spots on the surface... Agent: Life Technologies Corporation C/o Intellevate

20100173318 - Method and system for modeling cellular metabolism: This invention relates to methods and systems for in silico or bioinformatic modeling of cellular metabolism. The invention includes methods and systems for modeling cellular metabolism of an organism, comprising constructing a flux balance analysis model, and applying constraints to the flux balance analysis model, the constraints selected from the... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pennsylvania State University

20100173306 - Method for detecting g-quadruplex, method for detecting g-quadruplex-forming dna and method for determining telomerase activity: i

20100173317 - Method for diagnosing non-small cell lung cancer: Disclosed are methods for detecting non-small cell lung cancer (NSCLC) using differentially expressed genes KIF11, GHSR1b, NTSR1, and FOXM1. Also disclosed are methods of identifying compounds for treating and preventing NSCLC, based on the interaction between KOC1 and KIF11, or NMU and GHSR1b or NTSR1.... Agent: Townsend And Townsend And Crew, LLP

20100173287 - Method of analyzing nucleic acid: According to the present invention, stable amplification of a small amount of nucleic acid and analysis of the same with good sensitivity can be realized by improving efficiency of hybridization primers or probes with a probe. Specifically, the present invention relates to a method of analyzing nucleic acid comprising: a... Agent: Mattingly & Malur, P.C.

20100173304 - Method of dna sequencing: The invention includes a method for sequencing DNA by partially sequencing the bases of complementary strands of double-stranded DNA and combining the partial information from both strands of the double strand DNA to fully sequence the DNA. The invention also includes DNA sequences sequenced by the methods, computer readable mediums... Agent: Intellectual Property Group Fredrikson & Byron, P.A.

20100173285 - Methods and compositions for detecting a drug resistant egfr mutant: Polymerase chain reaction primers and methods directed to detecting the EGFR mutant C→T at the position corresponding to base 2369 of EGFR cDNA. The invention provides a PCR primer that hybridizes under suitable PCR conditions to a polynucleotide sequence 5′ in each respective strand to a mutation of an EGFR... Agent: Proteus Patent Practice LLC

20100173291 - Methods and kits for detecting fetal cells in the maternal blood: Provided is a method of identifying a trophoblast by detecting in cells of a biological sample, with the proviso that the biological sample does not comprise a placental tissue, expression of a trophoblast marker selected from the group consisting of an annexin IV, a cytokeratin-7, a cytokeratin-8 and a cytokeratin-19;... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100173289 - Methods for assessing cancer susceptibility to carcinogens in tobacco products: The present invention demonstrates the differential sensitivity of PBLs from lung cancer patients and healthy controls to NNK-induced genetic damage. The data provide convincing evidence that the preferred CBMN assay is a robust test for detection of this sensitivity and yields results that are a good predictor of, for example,... Agent: Fulbright & Jaworski L.L.P.

20100173320 - Methods for detecting nucleic acids indicative of cancer: The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer.... Agent: Choate, Hall & Stewart LLP

20100173296 - Methods of stratifying adolescent idiopathic scoliosis, isolated nucleic acid molecules for use in same and kits using same: A method of stratifying a subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting Paired-like homeodomain transcription factor 1 (Pitxi) expression in the cell sample; whereby the results of the detecting step enables the stratification of the subject having AIS as belonging to... Agent: Goudreau Gage Dubuc

20100173310 - Microchip large-volume pcr with integrated real-time ce detection: A microfluidic device is provided with appropriate integrated structures to conduct large volume PCR and end-point or real-time capillary electrophoresis detection The microfluidic device includes a substrate having an amplification chamber of a volume of nucleic acid, wells disposed on the substrate, flow channels connecting the wells and the chamber... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100173290 - Monitoring of enzymatic processes by using magnetizable or magnetic objects as labels: The present invention provides a method and device for monitoring an enzymatic process of a biological molecule by, at least once, during the enzymatic process determining an amount of magnetic particles attached to a sensor surface. The method and device according to embodiments of the present invention may be used... Agent: Philips Intellectual Property & Standards

20100173303 - Multibase delivery for long reads in sequencing by synthesis protocols: The present technology relates to molecular sciences, such as genomics. More particularly, the present technology relates to methods for obtaining long lengths of sequencing data.... Agent: Knobbe Martens Olson & Bear LLP

20100173286 - Mutant cells suitable for recombinant polypeptide production: A mutated bacterial cell producing at least one heterologous polypeptide of interest, wherein said cell has a reduced expression-level of YugJ (SEQ ID NO: 2) or a homologue thereof when compared with an otherwise isogenic but non-mutated cell; methods for producing said cell, and methods for producing a polypeptide of... Agent: Novozymes North America, Inc.

20100173299 - Mutant nucleic acid related to chronic myeloproliferative disorder and method of evaluating chronic myeloproliferative disorder: A new mutant gene related to the onset of CMPD, particularly, the new mutant gene related to the onset of CMPD in patients who develop CMPD despite of JAK2V617F-negative, and an evaluation method for evaluating CMPD are provided. By detecting the following mutation in a JAK2 gene or an EPOR... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100173300 - Noncontact stirring method, noncontact stirring apparatus, method and apparatus for reacting nucleic acid hybridization using the apparatus, method for detecting nucleic acid in sample, apparatus for detecting nucleic acid, method for detecting antibody i: A noncontact stirring method, a noncontact stirring apparatus, a method and apparatus for reacting nucleic acid hybridization using the apparatus, a method for detecting nucleic acid in a sample, an apparatus for detecting nucleic acid, a method for detecting antibodies in a sample, and an apparatus for detecting antibodies in... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100173292 - Novel gpiiia gene: An object of the present invention is to provide a probe, primer, primer set and antibody for determining neonatal alloimmune thrombocytopenic purpura or the risk of developing it. According to the present invention, there is provided a probe, primer, primer set and antibody for use in the detection of the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100173297 - Novel serpentine transmembrane antigens expressed in human cancers and uses thereof: Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four... Agent: Arnold & Porter LLP (24126) Attn:IPDocketing Dept.

20100173311 - Nucleic acid amplification with allele-specific suppression of sequence variants: The present invention is an improved method of selective amplification of certain variants of the target sequence, enhanced by allele-specific suppression of amplification of one or more of the other variants of the target sequence. The improvement is accomplished by providing an oligonucleotide, capable of hybridizing to the desired variant... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100173307 - Nucleic acid modules for expression and tagging of membrane proteins and methods of use: Described herein are nucleic acid modules for cloning, expression and tagging of eukaryotic membrane proteins. The nucleic acid modules include a receptor for advanced glycation end products (RAGE) signal sequence, a nucleic acid sequence encoding a tag and a multiple cloning sequence (MCS). Any membrane protein of interest can be... Agent: Klarquist Sparkman, LLP

20100173302 - Positive control proteins for glucose transporter proteins and processes for the generation of such positive control proteins: Positive controls for experimentation related to membrane-bound glucose transporter proteins and methods for preparing such positive controls, such proteins including GLUT1, GLUT4, GLUT5, and GLUT12.... Agent: Luedeka, Neely & Graham, P.C.

20100173316 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20100173301 - Prognostic tools to predict the efficacy of drug treatment targeting chromatin dna or enzymes acting on dna: Disclosed are methods of predicting cell response to drug-based therapy using both PCR-Stop assays and real time PCR assays. Methods herein may be used for assessment of drug effect, evaluation of regimen suitability for a given patient, and/or for determination of an optimal drug dose. Also provided are isolated oligonucleotide... Agent: Castellano PLLC

20100173288 - Serum/plasma micronas and uses thereof: This invention provides a combination of microRNAs for evaluating the physiological and/or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum/plasma of a subject; and a method for evaluating the physiological and/or pathological condition of a subject, wherein the method includes determining... Agent: Connolly Bove Lodge & Hutz, LLP

20100173309 - Situ methods for gene mapping and haplotyping: The present invention is directed to in situ methods for providing a definitive haplotype of a subject. The haplotype information generated by the methods described herein is more accurate than that provided by prior art methods that only give an inferred haplotype. Accordingly, in one aspect the present invention provides... Agent: Foley And Lardner LLP Suite 500

20100173308 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: Searete LLC Clarence T. Tegreene

20100173324 - Anti-cd27 antibody: The present invention can provide a monoclonal antibody or an antibody fragment thereof, which specifically recognizes a polypeptide encoded by CD27 gene containing an O-linked sugar chain to which galactose is not bound, and binds to its extracellular region; a hybridoma which produces the antibody; a DNA which encodes the... Agent: Sughrue-265550

20100173325 - Composition and method for analysis of target analytes: A method of detecting analytes includes providing a mixture containing analytes to be analyzed and microparticles coated with competitive inhibitors of the analytes. First antibodies are reacted with the analytes and the competitive inhibitors under competitive binding conditions. The first antibodies bound to the competitive inhibitors are measured using flow... Agent: Houst Consulting (millipore)

20100173323 - Glycosylation engineered antibody therapy: The instant invention is drawn to methods of generating a glycosylation-engineered antibody, and using the glycosylation-engineered antibody for treating a patient, particularly a cancer patient or a patient with an immune disease or disorder. The instant invention is also drawn to methods of generating a glycosylation-engineered antibody for use in... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100173321 - Making a diagnosis in cases of cardiac disease using a combination of markers: The present invention concerns methods for diagnosing myocardial infarction, for performing risk stratification of myocardial infarction, for making a prognosis of a disease course in a myocardial infarction patient, for identifying a patient with elevated risk of myocardial infarction, or combinations thereof, wherein a determination of at least three markers... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100173327 - Nonhuman model animal lacking the ability to control lymphocyte migration: The present invention provides a animal model useful in identifying a molecule controlling in a lymphocyte-specific manner migration and thus elucidating immune-related diseases and pathogenic conditions such as allergy, autoimmune diseases, GvH and graft rejections at a molecular level, or in developing a novel therapy. A nonhuman animal model such... Agent: Frommer Lawrence & Haug

20100173322 - Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways: The invention discloses nearly 219 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the NPM-ALK translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100173326 - Substrate and method for producing the substrate: A self assembling monolayer formed by the self assembling molecules is caused to bond onto the surface of a base material, and chelators are caused to bond onto the self assembling monolayer, to produce a substrate, in which the chelators are bound to the self assembling monolayer at a density... Agent: Young & Thompson

20100173328 - Apparatus for measuring a cell number and a quantity of a cellular protein expression and the method thereof: The apparatus and method thereof for harmlessly and continuously measuring and recording a target protein expression and a number of growing cells are provided. By causing an AC current to flow through an electrode where cells grows thereon, the target protein expression and the number of growing cells are obtained... Agent: Haverstock & Owens

20100173329 - Exposed proliferation-related peptides, ligands and methods employing the same: Novel thymidine kinase (TK1) derived peptide consisting of the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2 is employed to obtain ligands having specificity to the peptide. The ligand may be an antibody or fragment thereof and may be used in various methods and kits for health... Agent: Porter Wright Morris & Arthur, LLP Intellectual Property Group

20100173332 - method for the fluorescent detection of nitroreductase activity using nitro-substituted aromatic compounds: A method utilising one or more fluorogenic probes, for the detection of nitroreductase activity. The non-fluorescent probes are reduced in the presence of nitroreductase to form fluorescent derivatives that may be detected using fluorescence spectroscopy. In particular, the method may be used to detect and/or identify a plurality of nitroreductase... Agent: Occhiuti Rohlicek & Tsao, LLP

20100173333 - Method of screening candidate compounds for susceptibility to biliary excretion: A method of screening a candidate compound for susceptibility to biliary excretion. The method includes the steps of providing a culture of hepatocytes, the culture having at least one bile canaliculus; exposing a candidate compound to the culture; and determining an amount of candidate compound in the at least one... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20100173330 - Immunoassay assembly and methods of use: The present invention relates to an improved system for efficiently and accurately performing immunoassays, such as ELISAs. The invention provides an immunoassay assembly which includes a flow-through unit and an aspiration pump. The immunoassay flow-through unit includes an outer seal; at least one bed support; an inner seal; and a... Agent: Intellectual Property Dept. Dewitt Ross & Stevens Sc

20100173331 - Novel notch-origin polypeptides and biomarkers and reagents using the same: It is intended to provide extracellular markers whereby Notch signal transduction can be detected. Polypeptides (Nβ), which are novel peptides originating in Notch protein and released form cells in the step of the nuclear migration of NICH (Notch intracellular cytoplasmic domain) due to the extracellular digestion and the subsequent protein... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100173334 - Cancer evaluation method using haptoglobin beta-chain defined by antibody rm2: The object of the present invention is to identify a molecule that is specifically recognized by antibody RM2 in tissue or serum of a cancer patient, and provide a method for diagnosing cancer in a simple manner with high specificity using the molecule as an indicator. The present method comprises... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100173335 - Fast microbiological analysis device and method: The method includes the step of procuring a device of the above kind, the step of disposing said support (19) at said predetermined location, the step of spraying said reagent onto said support (19) and, simultaneously with the spraying step, the step of measuring the quantity of light emitted in... Agent: Nields, Lemack & Frame, LLC

20100173336 - Methods for assessment of cardiovascular disease risk: Methods are provided for more accurately assessing cardiovascular disease (CVD) risk factors in individuals or populations, using a bimodal analysis including cholesterol-based CVD risk markers together with serum triglyceride levels. Preferably, if a CVD marker (e.g., the ratio of total cholesterol to HDL) yields high risk factors, these factors may... Agent: Hovey Williams LLP

20100173338 - Biomarkers for cancer sensitivity and uses thereof: Disclosed herein are biomarkers and uses thereof for evaluating anti-cancer efficacy and sensitivity.... Agent: Fish & Richardson P.C.

20100173339 - Platelet activation markers as indicators for anti-platelet therapy: Methods for determining the appropriateness of anti-platelet therapy in a patient with a platelet-affected disease. The Mean Platelet Component value in a patient blood sample is determined corresponding to the patient's platelet activation status. A high platelet activation status indicates the appropriateness of anti-platelet therapy.... Agent: Siemens Corporation Intellectual Property Department

20100173337 - Quantification of non-reducing end glycan residual compounds: Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100173340 - Use of hematopoietic growth factor inducible neurokinin-1 (hgfin) as a novel biomarker: The invention provides, in certain embodiments, a method of detecting an indicator of renal injury or renal disease. The method entails assaying a urine sample for hematopoietic growth factor inducible neurokinin-1 (HGFIN), wherein the presence of HGFIN at an elevated level indicates the presence and/or degree of renal injury or... Agent: Weaver Austin Villeneuve & Sampson LLP

20100173341 - Apoptosis-based evaluation of chemosensitivity in cancer patients: Induction of apoptosis in target cells is a key mechanism by which chemotherapy induces cell killing. An in vitro system has been established for determining carboplatin and paclitaxel (Taxol) chemosensitivity of epithelial ovarian cancer cells, where measurements of caspase-3 activation are surrogate markers for activation of chemotherapy-induced programmed cell death.... Agent: Cooley LLP Attn: Patent Group

20100173342 - Biomarker and method for determining an oxidative stress level: The present invention relates to a biomarker and a method for determining an oxidative stress level in a biological sample, which employs co-factor-dependent oxidative stress parameters, as well as a kit adapted for carrying out such a method. Preferably the co-factor is tetrahydrobiopterin.... Agent: Thorpe North & Western, LLP.

20100173343 - Method of determining 1,5-anhydroglucitol, and reagent composition for determining 1,5-anhydroglucitol: A method for the determination of 1,5-anhydroglucitol, characterized by using any one of the following proteins (a) to (c): (a) a protein which comprises an amino acid sequence depicted in SEQ ID NO:2; (b) a protein which comprises an amino acid sequence having the deletion, substitution and/or addition of one... Agent: Darby & Darby P.C.

20100173351 - Cardiac reentry model chip and apparatus and method for evaluating drug using the cardiac reentry model chip: A chip has been developed that can accurately measure cell potential and cell morphology on a single cell basis. The chip also constitutes a cardiac model that comprises a closed loop whereupon cardiomyocytes and fibroblasts are suitably dispersed and arranged, and that can evaluate the effects of a drug thereon.... Agent: Sughrue Mion, PLLC

20100173349 - Cellular libraries of peptide sequences (clips) and methods of using the same: The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane.... Agent: Bozicevic, Field & Francis LLP

20100173345 - Detection of blood plasma amygdalin of dissipating blood stasis botanical: A detection method of blood plasma amygdalin of dissipating blood stasis botanical is disclosed. The method includes: (1) adding 2-5 mol/L phosphoric acid to plasma of mammalian administered dissipating blood stasis botanical and mixing the solution of plasma-phosphoric acid (1:2-3, v/v), applying the solution to small column of Waters Oasis... Agent: Butzel LongIPDocketing Dept

20100173350 - Method for discriminating between benign and malignant prostate tumors: The method for discriminating between benign and malignant prostate tumors relates to analyzing samples of blood, urine and tissue by fluorescence spectroscopy in order to detect the presence of naturally occurring molecules in the fluids and tissue that serve as biomarkers indicative of cancer in the human body. The analysis... Agent: Litman Law Offices, Ltd.

20100173352 - Method for preparing cells for engraftment: The present invention relates to an in vitro method for preparing progenitor cells having an increased adhesivity, wherein progenitor cells are contacted with an agonist of the CD47/IAP receptor thereby yielding progenitor cells presenting an increased adhesivity.... Agent: Stites & Harbison PLLC

20100173348 - Method of evaluating visceral fat accumulation, visceral fat accumulation-evaluating apparatus, visceral fat accumulation-evaluating method, visceral fat accumulation-evaluating system, visceral fat accumulation-evaluating program, recording medium, and m: According to the method of evaluating visceral fat accumulation of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and a visceral fat accumulation condition in the subject is evaluated based on the measured amino... Agent: Foley And Lardner LLP Suite 500

20100173346 - Methods for detecting coronary artery disease: Markers are provided for detecting coronary artery disease. Levels of these markers are indicative of a patient being at risk of having or developing coronary artery disease.... Agent: K&l Gates LLP

20100173344 - Methods for isolating and using pituitary adenoma stem cells and pituitary adenoma cells: The present invention describes pituitary adenoma stem cells, pituitary carcinoma stem cells, a method of obtaining the stem cells, and a method of using the stem cells. Uses of the pituitary stem cells include but are not limited to producing pituitary hormones and identifying drugs to treat pituitary disease conditions... Agent: Davis Wright Tremaine LLP/los Angeles

20100173347 - Stabilized gold nanoparticles and methods of making the same: The present disclosure relates to water-soluble stable gold nanoparticles (AuNPs) and methods for making the same. The present disclosure also includes the use of AuNPs, for example, in biological, medical and environmental assays for the detection of analytes, as well as biological and medical imaging.... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20100173353 - Lysis reagent formulation: Subject matter of the invention is a lysis reagent formulation for binding components of a sample in the form of a tablet comprising a multitude of magnetic particles which are held together with the aid of excipients, a chaotropic salt and an excipient and the use of this lysis reagent... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100173355 - Means for sequestration and conversion of cox and nox, conox: The instant invention presents means for sequestering COX and NOX; further comprising algae means to convert COX into oxygen (O2), as well as biological means to convert sulfides into elemental sulfur. The instant invention comprises algae, heterotrophs, facultative bacteria and Thiobacillus. The instant invention comprises means of light (photon) transfer.... Agent: Richard A. Haase (inventor)

20100173354 - Method for the fermentation of ensilaged renewable raw materials: A method of fermenting ensilaged renewable raw materials, wherein the method comprises washing and crushing ensilaged renewable raw materials, removing at least some water from the washed and crushed ensilaged renewable raw materials, subjecting the washed and crushed ensilaged renewable raw materials to hydrolysis, and subjecting hydrolysis products to a... Agent: Greenblum & Bernstein, P.L.C

20100173356 - Increased production of a target product via stabilization of mrna: The present invention relates to newly identified mRNA stabilizing elements useful for the production of a target fermentation product, such as e.g. vitamins or enzymes, in particular riboflavin (vitamin B2), biotin, pantothenic acid (vitamin B5), folic acid, thiamin, pyridoxine (vitamin B6), vitamin B12, xylanase, amylase, protease, glucanase, amylomaltase or maltogenic... Agent: Nixon & Vanderhye, PC

20100173358 - Method for obtaining a valuable product, particularly starch, from grain flour: A process for obtaining a starch and a protein or both from grain flour, the process steps comprising: providing grain flour; mixing the grain flour with processed or fresh water to form a slurry; separating the slurry into it at least two fractions, the at least two fractions including two... Agent: Barnes & Thornburg LLP

20100173357 - Method of making activated carboxypeptidases: The invention is related to a method for making an activated carboxypeptidase in a fungi cell comprising introducing a DNA sequence encoding a proform of the carboxypeptidase wherein a Kex2 site has been introduced in the prosequence of the carboxypeptidase, culturing the fungi cell under conditions suitable for expression of... Agent: Novo Nordisk, Inc. Intellectual Property Department

20100173359 - Enhanced biotherapeutic production using inhibitory rna: Compositions, kits, systems, equipment, and protocols utilize synthetic siRNA having a delivery facilitating moiety in improved bioprocesses that enhance the production of biomaterials. The siRNA can target genes associated with the following: 1) deleterious vector derived genes; 2) genes that confer non-optimal growth or differentiation properties to the cells; 3)... Agent: Workman Nydegger 1000 Eagle Gate Tower

20100173361 - Hepatocyte growth factor (hgf) binding proteins: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain... Agent: Goodwin Procter LLP Attn: Patent Administrator

20100173362 - Hepatocyte growth factor (hgf) binding proteins: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain... Agent: Goodwin Procter LLP Attn: Patent Administrator

20100173360 - Zinc oxide-binding antibody and use thereof: The present invention relates to a zinc oxide-binding antibody having high stability and binding activity, and high-throughput sensing technology using the antibody, such as biosensors. Specifically, the present invention relates to a peptide-grafted antibody that contains a zinc oxide-recognizing peptide in the CDR H-1 region of a camel antibody, and... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100173365 - Dna polymerase fusions and uses thereof: The present invention discloses methods of using DNA polymerase fusions at high pH in PCR, DNA sequencing and mutagenesis protocols.... Agent: Agilent Techologies Inc

20100173364 - Repair of nucleic acids for improved amplification: Methods and compositions are provided for repairing a polynucleotide so that it can be copied with improved fidelity and/o yield in, for example, an amplification reaction. This involves the use of a reaction mixture that includes a DNA ligase and an effective amount of at least one endonuclease as well... Agent: Harriet M. Strimpel, D. Phil.

20100173363 - Use of single-stranded nucleic acid binding proteins in sequencing: The invention provides methods for stabilizing a nucleic acid sequencing reaction. Generally, methods of the invention include exposing a target nucleic acid to a single-stranded nucleic acid binding protein and performing a sequencing reaction.... Agent: Brown Rudnick LLP

20100173366 - Polypeptides having l-arabinose isomerase activity exhibiting minimum dependence on metal ions for its activity and for thermostability and nucleic acids encoding the same: The invention concerns identification of a gene encoding a novel L-arabinose isomerase of the Bacillus stearothernivphilus strain US 100 (L-AI US 100), a L-arabinose isomerase expressed from said gene, recombinant vectors harbouring said gene, microorganisms transformed with said vector, a protocol for preparing and purifying said recombinant protein, biochemical and... Agent: Ladas & Parry LLP

20100173367 - Functionalized molecules comprising an autosilification moiety and methods of making and using same: The present invention provides functionalized molecules comprising a covalently linked autosilification moiety; and methods for making and using the functionalized molecules. The present invention provides nucleic acids comprising nucleotide sequence encoding polypeptides comprising an autosilification moiety. The present invention further provides silica matrices comprising a subject functionalized molecule, as well... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP

20100173368 - Method for producing l-lysine: An Escherichia bacterium having dihydrodipicolinate synthase and aspartokinase, both of which are desensitized to feedback inhibition by L-lysine. The intracellular activity of dihydrodipicolinate reductase in this bacterium can also be enhanced. Furthermore, a diaminopimelate dehydrogenase gene can be introduced into this bacterium, or intracellular activities of tetrahydrodipicolinate succinylase and succinyl... Agent: Cermak Nakajima LLP Acs LLC

20100173369 - Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent: Codexis, Inc.

20100173370 - Fuel production: An apparatus that includes a first reactor and a return mechanism. The first reactor has an inlet to receive a mixture comprising a first reactant, a second reactant, a reaction product, and an inert solvent that dissolves at least a portion of the first and second reactants, an enzyme to... Agent: Occhiuti Rohlicek & Tsao, LLP

20100173371 - Medium comprising fermented korean hot pepper paste or soybean sauce and production method of gamma - aminobutyric acid: The present invention relates to a medium composition comprising fermented Korean hot pepper paste, undiluted solution of brewed soy sauce or acid hydrolyzed soy sauce, and a method for producing gamma-aminobutyric acid (GABA) using the medium. More precisely, the present invention relates to a medium composition for culturing lactobacillus having... Agent: Swanson & Bratschun, L.L.C.

20100173372 - Recombinant halohydrin dehalogenase polypeptides: The present disclosure provides engineered halohydrin dehalogenase (HHDH) polypeptides having improved enzyme properties as compared to the wild-type HHDH enzyme HheC and other reference engineered HHDH polypeptides. Also provided are polynucleotides encoding the engineered HHDH enzymes, host cells capable of expressing the engineered HHDH enzymes, and methods of using the... Agent: Codexis, Inc.

20100173374 - Method for employing ear corn in the manufacture of ethanol: Ear corn is picked from corn fields by ear corn harvesters and transported to a central shelling station associated with an ethanol manufacturing facility. Shelled corn from the central shelling station is processed into ethanol at the ethanol manufacturing facility, and corn cobs from the central shelling station are burned... Agent: Marshall, Gerstein & Borun LLP

20100173373 - Thermophilic microorganisms for ethanol production: A thermophilic microorganism is modified to permit the increased production of ethanol, wherein a first modification is the inactivation of the lactate dehydrogenase gene and a second modification upregulates the pyruvate dehydrogenase gene.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100173375 - Closed-loop system for growth of aquatic biomass and gasification thereof: Processes, systems, and methods for producing combustible gas from wet biomass are provided. In one aspect, for example, a process for generating a combustible gas from a wet biomass in a closed system is provided. Such a process may include growing a wet biomass in a growth chamber, moving at... Agent: Thorpe North & Western, LLP.

20100173376 - Functionalization of carbon nanotubes with metallic moieties: A method of functionalizing carbon nanotubes with metallic moieties is disclosed. Carbon nanotubes are first associated with one or more binding moieties to provide carbon nanotubes encapsulated by the binding moieties. The encapsulated carbon nanotubes are then contacted with a metal salt or a metal complex that binds to the... Agent: K&l Gates LLP

20100173377 - N-sulfonylaminocarbonyl containing compounds: Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonylaminocarbonyl group... Agent: 3m Innovative Properties Company

20100173378 - Avian telomerase reverse transciptase: The present invention notably relates to novel recombinant telomerase reverse transcriptases, nucleic acid molecules coding them, cells comprising said nucleic acid molecule and use of these cells for the production of substance of interest.... Agent: Buchanan, Ingersoll & Rooney PC

20100173379 - Compositions of aminoacyl-trna synthetase and uses thereof: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20100173380 - Compositions of aminoacyl-trna synthetase and uses thereof: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20100173381 - Crystal structures of hiv-1 protease inhibitors bound to hiv-1 protease: Described herein are methods for rational design of inhibitors of HIV-1 protease, and crystal structures of HIV-1 protease inhibitors bound to HIV-1 protease.... Agent: Fish & Richardson PC

20100173382 - Humanized anti-5t4 antibodies and anti-5t4/calicheamicin conjugates: Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same.... Agent: Womble Carlyle Sandridge & Rice, PLLC Attn: Patent Docketing

20100173384 - Methods for protein labeling based on acyl carrier protein: A method for labeling acyl carrier protein (ACP) fusion proteins with a wide variety of different labels is disclosed. The method relies on the transfer of a label from a coenzyme A type substrate to an ACP fusion protein using a holo-acyl carrier protein synthase (ACPS) or a homologue thereof.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100173383 - Nuclear factor of activated t cells receptor: The present invention provides a novel transmembrane protein, which is a nuclear factor of activated T cells (‘NFAT’) receptor, and related compositions and methods.... Agent: Nikolaos C. George Jones Day

20100173385 - Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins and its application thereof: Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose-6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biological activity are described. The methods are useful for modifying glycoproteins, including those produced by recombinant protein expression systems, to increase... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100173386 - Prokaryotic expansin protein activating cellulose expansion and cellulose - degrading composition comprising the same: Provided is a prokaryotic expansin protein capable of expanding cellulose. The prokaryotic expansin protein performs the same function as existing plant expansin proteins. The prokaryotic expansin protein can be produced at greatly reduced cost on an industrial scale, unlike plant expansin proteins. Particularly, when lignocellulosic biomass is hydrolyzed into glucose... Agent: Christie, Parker & Hale, LLP

20100173387 - Method for producing adenovirus vectors for gene therapy and dna sequences used therefor: Method for producing adenovirus vectors for gene therapy and auxiliary vectors used therefor. The method is based on the multiplication of gutless adenoviruses that lack adenovirus-coding sequences by cotransfecting them with an auxiliary or helper adenovirus that has an attB sequence of the &phis;C31 bacteriophage inserted between the adenovirus packaging... Agent: Ladas & Parry LLP

20100173388 - Recombinant poxvirus expressing homologous genes inserted into the poxviral genome: The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use... Agent: Law Office Of Salvatore Arrigo

20100173389 - Process for bacterial production of polypeptides: Refractile particles containing a heterologous polypeptide as an insoluble aggregate are recovered from bacterial periplasm. The process involves culturing bacterial cells so as to express nucleic acid encoding phage lysozyme and nucleic acid encoding the heterologous polypeptide under separate promoters, disrupting the cells mechanically to release the phage lysozyme so... Agent: Arnold & Porter LLP (24126) Attn:IPDocketing Dept.

20100173390 - Oxaloacetate hydrolase deficient fungal host cells: The present invention relates to isolated nucleic acid sequences encoding polypeptides having oxaloacetate hydrolase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.... Agent: Novozymes North America, Inc.

20100173391 - Anaerobic digester employing circular tank: A method and apparatus for the anaerobic digestion of high-solids waste material. The apparatus includes a closed container having a relatively circular outer wall. The closed container has a first passage having an inlet in which the waste material flows in a first direction, a second passage in which the... Agent: Whyte Hirschboeck Dudek S C Intellectual Property Department

20100173392 - Room temperature elution of nucleic acids: The present invention provides compositions and methods for efficient recovery of nucleic acids, in particular DNA, from storage media. The present invention provides a method for using an alkaline elution buffer and mechanical agitation to elute nucleic acids from dried samples on storage media at room temperature. In particular, the... Agent: Cooley LLP Attn: Patent Group

20100173396 - Amperometric immunosensor: a second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20100173394 - Droplet-based assay system: Systems, including apparatus and methods, for performing assays. These systems may involve separating sample components by partitioning them into droplets or other partitions, amplifying or otherwise reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.... Agent: Kolisch Hartwell, P.C.

20100173397 - Dual path immunoassay device: The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test line or test site with immobilized antigens or... Agent: Gordon & Jacobson, P.C.

20100173395 - Microfluidic devices for fluid manipulation and analysis: The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare... Agent: Seed Intellectual Property Law Group PLLC

20100173393 - Microfluidic valve and method of making same: The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are... Agent: Knobbe Martens Olson & Bear LLP

20100173398 - Hand-held microfluidic testing device: A hand-held microfluidic testing device is provided. The testing device includes a housing having at least one cartridge receiving port and at least one cartridge for inputting to the cartridge receiving port, and an optical detection system in the housing, where the optical detection system is disposed to analyze at... Agent: Lumen Patent Firm

20100173401 - Culture apparatus: A culture apparatus includes a culture chamber in which culture is cultured, a shelf plate included in the culture chamber, on which the culture is placed, and shelf rests in a left-and-right pair configured to support the shelf plate and a plurality of shelf supports configured to support the shelf... Agent: Osha Liang L.L.P.

20100173399 - Fuel production: An apparatus that includes a first reactor and a return mechanism. The first reactor has an inlet to receive a mixture comprising a first reactant, a second reactant, a reaction product, and an inert solvent that dissolves at least a portion of the first and second reactants, an enzyme to... Agent: Occhiuti Rohlicek & Tsao, LLP

20100173402 - Methods and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof: The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the metastatic potential of such cancer cells and drug screening assays for the identification of agents having anti-metastatic potential. The present invention further... Agent: Hoffmann & Baron, LLP

20100173400 - Thermal cycler for pcr: An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric... Agent: Life Technologies Corporation C/o Intellevate

20100173403 - Non-isopycnic cell purification using percoll: A method of “non-isopycnic” cell isolation and purification has the steps of adding a sample of blood to a defined volume to a corresponding ratio volume of EDTA solution to produce a volume of anti-coagulated blood; taking a predetermined volume of the anti-coagulated blood and placing it in a first... Agent: David L. King, Sr.

20100173405 - Double-stranded nucleic acid molecule cancer cell proliferation inhibitor and pharmaceutical agent suitable for prevention or treatment of uterine cancer, breast cancer, and bladder cancer: A double-stranded nucleic acid molecule for suppressing the expression of at least one of COX7RP and Efp genes which includes (a) a sense strand which includes a nucleotide sequence corresponding to a target sequence indicated by any one of SEQ ID Nos.: 1 to 38 and (b) an antisense strand... Agent: Buchanan, Ingersoll & Rooney PC

20100173404 - Partial fragment of reic/dkk-3 gene and cancer therapeutic agent comprising the same: This invention provides an inducer of apoptosis in cancer cells comprising a fragment of the REIC/Dkk-3 gene and a cancer therapeutic agent comprising the same. This invention also provides a polynucleotide fragment encoding the REIC/Dkk-3 protein (a) or (b), which encodes a polypeptide having apoptosis activity: (a) a polynucleotide encoding... Agent: Fitch, Even, Tabin & Flannery

20100173407 - Inhibition of gene expression: There is provided a method of inhibiting gene expression by locating a 5′-5 donor splicing site sequence in the 3′ UTR of a gene or within coding sequence containing the stop codon of a gene. Stability of homologous mRNA in trans is also adversely affected leading to a reduction in... Agent: Pepper Hamilton LLP

20100173408 - Receptor-based interaction trap: Described is a recombinant receptor comprising an extracellular ligand-binding domain and a cytoplasmic domain that comprises a heterologous bait polypeptide. The recombinant receptor is activated by binding of a ligand to the ligand-binding domain and by binding of a prey polypeptide to the heterologous bait peptide. The invention also discloses... Agent: Traskbritt, P.C.

20100173406 - Virus mediated cytoplasmic expression of dna vaccines: The present invention relates generally to methods, systems, and compositions for cytoplasmic delivery and expression of DNA vaccines. The present invention further relates to methods, systems, and compositions for expressing an immune response modulator in an animal.... Agent: Morrison & Foerster LLP

20100173409 - Culture media for developmental cells containing elevated concentrations of lipoic acid: A composition and method for in vitro fertilization is provided which uses culture media comprising elevated concentrations of lipoic acid. More specifically, the invention provides culture media for developmental cells having a lipoic acid concentration of 5 μM to 40 μM. Culture media that include lipoic acid at concentrations within... Agent: Pearne & Gordon LLP

20100173411 - Adipose-derived stem cells and lattices: The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues... Agent: Mandel & Adriano

20100173410 - Cultivation of primate embryonic stem cells: The invention relates to methods for culturing human embryonic stem cells by culturing the stem cells in an environment essentially free of mammalian fetal serum and in a stem cell culture medium including amino acids, vitamins, salts, minerals, transferrin, insulin, albumin, and a fibroblast growth factor that is supplied from... Agent: Quarles & Brady LLP

20100173412 - Eukaryotic layered vector initiation systems: The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems... Agent: Novartis Vaccines And Diagnostics Inc.

20100173413 - Pyridine compounds: e

20100173414 - Methods of deriving differentiated cells from stem cells: The present invention provides a method of generating definitive endoderm, mesoderm, or ectoderm cells. The method includes culturing embryonic stem cells, parthenogenetic cells, or induced pluripotent stem cells in the presence of a demethylation agent, a histone deacetylase inhibitor, or a combination thereof, and thereafter, culturing the stem cells in... Agent: Dla Piper LLP (us)

20100173415 - Carrier for cell cultivation: A carrier for cell cultivation having stress of 10-30 kPa at 10% load, preparing a material, which has physical property similar to cartilage tissue of vivo, by lyophilization using high concentrated collagen dispersion, solution or mixture thereof as a starting material, then performing insolubilizing treatment to regulate physical strength and... Agent: Flynn Thiel Boutell & Tanis, P.C.

20100173416 - Method and apparatus for inoculating and streaking a medium in a plate: An apparatus for inoculating and streaking a solid growth culture medium in a plate, the streaking using a streaking applicator having a line of resiliently and flexibly supported spaced apart contact surfaces, the apparatus including: (a) an inoculating and streaking station including: a plate work position having a notional action... Agent: Crompton, Seager & Tufte, LLC

  
07/01/2010 > patent applications in patent subcategories. category listing

20100167259 - Apparatus and method for the preservation of pancreatic tissue and islet cells for transplantation: The present invention includes compositions and methods for the preparation, preservation and storage of organs (e.g., pancreatic islet cells) for transplantation by storing organs in which the organs are suspended in a solution for maintaining viability and the organ or cells are cooled in a refrigeration unit for the entire... Agent: Chalker Flores, LLP

20100167260 - Use of n-piperidine derivative compositions for protecting biological systems: The present invention relates to compositions and the use of such compositions in the formulation of preservation solutions for protecting mammalian (including human) biological systems such as biotechnological preparations (including recombin 10d3 ant proteins), organs, tissues (including whole blood and blood derivatives such platelets and plasma) and cells (including red... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100167261 - Platelet stabilization: Provided are methods for stabilizing mean platelet component and/or platelets in a sample comprising combining said sample with EDTA, a second anticoagulant, and one or more kinase inhibitors. Also provided are compositions for stabilizing a sample comprising platelets, and kits for storing a platelet sample.... Agent: Siemens Corporation Intellectual Property Department

20100167262 - Method and reagent for the specific identification and quantification of one or more proteins in a sample using in particular inductively coupled plasma-mass spectrometry: The invention relates to a method for the identification and quantification of one or more biomolecules in a sample containing a mixture of substances, wherein said method comprises the steps of, a) providing a sample which contains one or more biomolecules, b) providing a reagent for the analysis of biomolecules... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100167263 - Novel biosensor system based on recognition induced birefringence (rib): The present invention relates to a label-free biosensor system, a method for manufacturing said label-free biosensor system, its use for detecting biochemical reactions and/or bindings, enzymatic reactions, nucleic acid hybridizations, protein-protein interactions and protein-ligand interactions, as well as an assay method for detecting and/or quantifying an analyte of interest in... Agent: Kaplan Gilman & Pergament LLP

20100167266 - Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy: The present invention provides methods and compositions for determining whether a subject would benefit from co-receptor inhibitor therapy. In certain aspects, the methods can be used to determine whether a subject infected with a dual-mixed tropic population of HIV would benefit from CCCR5-inhibitor therapy or CXCR4-inhibitor therapy, the methods comprising... Agent: Jones Day

20100167269 - Detection method for human pappilomavirus (hpv) and its application in cervical cancer: Embodiments of the invention provide methods, assays, and kits for detecting HPV infection and HPV associated epithelial cell abnormalities, most notably those associated with pre-malignant and malignant epithelial cell lesions. Detection of HPV DNAs, genomes, and/or oncoproteins by nucleic acid hybridization assays and immunological assays can be used in early... Agent: Shu-ling Cheng

20100167267 - Mass spectrometric quantitation: Provided is a method of assaying for an analyte, which method comprises: a) combining a test sample, which may comprise the analyte, with a calibration sample comprising at least two different aliquots of the analyte, each aliquot having a known quantity of the analyte, wherein the sample and each aliquot... Agent: Crowell & Moring LLP Intellectual Property Group

20100167270 - Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus: The invention relates to improved strains of mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention further relates to methods for propagating mammalian MPV in the absence of trypsin. The methods and compositions of the invention can be used for the preparation... Agent: Medimmune, LLC Patrick Scott Alban

20100167272 - Method for detecting and analyzing pathogens in a sample: The present invention relates to a method and kits thereof for detecting the presence and/or the specific serogroup of a prokaryote selected from the group consisting of & pneumionae, N. meningitidis, H. influenzae, Adenovirus, Klebsiella Pneumonite, Lysteria monocytogenes, Escherichia coli and Streptococcus agalactiae in a sample taken from a human... Agent: Lucas & Mercanti, LLP

20100167271 - Method for screening blood using a preservative that may be in a substantially solid state form: Methods and devices useful for screening a blood product for a transfusion, pursuant to which leukocytes in drawn whole blood are contacted with a formaldehyde releaser screening preservative so that the presence of any residual leukocytes can be screened. A substantially solid state form preservative for one or more blood... Agent: Dobrusin & Thennisch PC

20100167264 - Quantitative analyte assay device and method: The present invention relates to an assay device and a method for using such for the quantitative determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid... Agent: Bernd W. Sandt

20100167268 - Seroconversion assays for detecting xenotropic murine leukemia virus-related virus: Methods of detecting, diagnosing, monitoring or managing an XMRV-related disease such as an XMRV-related neuroimmune disease such as chronic fatigue syndrome or an XMRV-related lymphoma such as mantle cell lymphoma in a subject are disclosed. These methods comprise determining presence, absence or quantity of antibodies against XMRV in a sample... Agent: Sonnenschein Nath & Rosenthal LLP

20100167265 - Vaccine against infectious agents having an intracellular phase, composition for the treatment and prevention of hiv infections, antibodies and method of diagnosis: A vaccine for treating and/or preventing infectious diseases where the infectious agent has at least one intracellular phase in the host during its multiplication cycle, is disclosed. The vaccine comprises at least one cryptic epitope of a cellular element that is carried along by an intracellular infectious agent as it... Agent: Foley And Lardner LLP Suite 500

20100167298 - puro-dhfr quadrifunctional marker and its use in protein production: This invention relates to industrial production of proteins. More specifically, the invention relates to the res-DHFR surrogate marker, which corresponds to a fusion between DHFR and a protein conferring resistance to a toxic compound or conferring a metabolic advantage. The invention further relates to the use of res-DHFR for screening... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100167283 - Analyte detection: A method of detecting an analyte in a sample, comprises the steps of: a) contacting the sample with a first ligand which binds specifically to the analyte and which is immobilised either on, or in the vicinity of, a sensor; b) prior to step (a) contacting the sample, or subsequent... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100167291 - Assessing expression of endogenous and exogenous genes: The present invention relates to compositions and methods to assess gene expression in cells. In particular, the present invention provides compositions and methods to assess expression from an exogenous gene and an endogenous version of the same gene in induced pluripotent stem cells.... Agent: Michael Best & Friedrich LLP

20100167287 - Crude biological derivatives competent for nucleic acid detection: The invention relates generally to the fields of making biological unit lysates or admixtures of body fluids and of RNA analysis. More specifically, it relates to direct methods for the detection of a specific sequence of RNA in a biological unit, for example a virus, cell or tissue sample, or... Agent: Life Technologies Corporation C/o Intellevate

20100167293 - Digital assay: The invention relates to methods and compositions for the detection of targets in a sample.... Agent: Life Technologies Corporation C/o Intellevate

20100167277 - Fret sequencing by dna scanning proteins: This patent describes a novel method for DNA sequencing. A DNA hybrid is created such that one strand contains nucleotides (A, G, C, T/U) bound to different FRET acceptor fluorophores that emits a distinct, differentiable wavelength. A DNA scanning protein carrying a FRET donor fluorophore is also added. A laser... Agent: Ryan Harper

20100167292 - High fidelity polymerases and uses thereof: The present invention relates to a DNA and RNA polymerases which have increased fidelity (or reduced misincorporation rate). In particular, the invention relates to a method of making such polymerases by modifying or mutating the nucleotide binding domain of the polymerase (e.g., the O-helix). The invention also relates to DNA... Agent: Life Technologies Corporation C/o Intellevate

20100167276 - High-throughput methods for quantifying cells in environmental and laboratory samples: The invention provides compositions (e.g., kits) and methods for determine the number of bacteria and other microbes in samples having low concentrations of microbes, for use, e.g., in biological warfare defense, microbe detection and agricultural and environmental sciences.... Agent: Morrison & Foerster LLP

20100167282 - Lateral-flow device and method to enhance detection signal for charged molecular targets: The present invention proposes a lateral-flow device and method to enhance the detection signal for charged molecular targets. The device includes a detection assembly and a direct current source. The direct current is applied on the device to reduce the amount of residual target on the membrane and the detection... Agent: Stout, Uxa, Buyan & Mullins LLP

20100167301 - Method and device for immunoassay using nucleotide conjugates: A composition of matter for use in an immunoassay devices and method comprising a signal antibody, e.g., FAB fragment, covalently linked to a first nucleotide; and one or more signal elements, e.g., signal enzymes such as ALP or fluorescent dyes, each covalently linked to a second nucleotide, wherein the first... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20100167302 - Method for predicting the response of a subject suffering from a viral infection of the liver to an antiviral therapy: The application relates to treatments for improving antiviral therapies and to method for determining whether or not antiviral therapies will be effective. In particular, the present application provides a method for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy... Agent: Novartis Corporate Intellectual Property

20100167273 - Method for selectively quantifying vegf isoforms in a biological sample and uses thereof: The present invention pertains to a novel method for quantifying VEGF various isoforms in a biological sample, with a very high selectivity and sensitivity. It also concerns a method for establishing a diagnostic and/or a prognosis concerning a patient potentially suffering from cancer, diabetes, or cardiovascular disease, comprising a step... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100167296 - Method of determining a chemotherapeutic regime and survival expectancy for non small cell lung cancer based on egfr/csf-1/ca ix expression: The present invention relates to a screening method for classifying and for deciding to apply chemotherapy to patients suffering from non-small-cell lung cancer (NSCLC), based on detecting the levels of EGFR, CSF-1 and CA IX.... Agent: Intellectual Property / Technology Law

20100167297 - Method of determining the time to progression of non small cell lung cancer after chemotherapy based on thioredoxin expression: The present invention relates to a method for predicting the Time to Progression (TTP) of non small cell lung carcinoma (NSCLC) patients treated with chemotherapy, based on the detecting the levels of expression of thioredoxin (TRX) in a biological sample of the patient, or based on simultaneously detecting the expression... Agent: Hoffmann & Baron, LLP

20100167285 - Methods and agents for evaluating inflammatory bowel disease, and targets for treatment: The invention provides methods for evaluating irritable bowel disease (IBD), including Crohn Disease and Ulcerative Colitis, methods for determining a patient's susceptibility to developing an IBD, and methods for determining a patient's IBD genotype. The invention includes methods, polynucleotides, polypeptides, and antibodies relating to disclosed variants of, and polymorphisms in,... Agent: Dowell & Dowell P.C.

20100167288 - Methods and compositions related to continuous flow thermal gradient pcr: Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR.... Agent: Ballard Spahr LLP

20100167274 - Methods and kits for identifying nucleic acid sequences: Methods and kits for detecting a nucleic acid sequence-of-interest in a sample are provided. The methods and kits use RecA-mediated strand exchange which is sensitive to a single-mismatch and which can exchange strands of non-denatured polynucleotide sequences of a sample. Thus the methods and kits of the present invention can... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100167294 - Methods for detecting nucleic acids in a sample: Systems and methods are provided for immobilizing nucleic acid amplicons and protein antigens on a test device. Amplicons comprising a synthetic binding unit and a detectable label are generated and immobilized at predetermined locations on a test device by specific binding interactions between the synthetic binding unit and a synthetic... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100167295 - Methods for haplotyping genomic dna: The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention relies on using a solid phase having a flat surface arrayed with oligonucleotides designed to specifically hybridize to each particular haplotype... Agent: Myers Bigel Sibley & Sajovec

20100167305 - Methods of detecting mutations associated with ataxia-ocular apraxia 2 (aoa2): e

20100167300 - Microenvironment niche assay for cips screening: The present invention provides three-dimensional microenvironment niches prepared from biomaterial compositions that supports growth and self renewal of stem cells. The invention also provides methods for inducing pluripotency in a somatic cell using chemical compounds, as well as methods for screening for compounds that can induce pluripotency in a somatic... Agent: The Law Office Of Jane K. Babin Professional Corporation

20100167290 - Molecule attachment to nanoparticles: Disclosed herein are molecule-modified nanoparticles and methods of making and using the same. More specifically, disclosed herein are molecule-modified nanoparticles wherein the molecule is attached to the surface of the nanoparticle via an oligonucleotide. Also disclosed are methods of preparing nanoparticles having oligonucleotides and molecules (e.g., biomolecules, such as proteins,... Agent: Marshall, Gerstein & Borun LLP

20100167289 - Multi-color time resolved fluorophores based on macrocyclic lanthanide complexes: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary... Agent: Morgan, Lewis & Bockius LLP (sf)

20100167278 - Novel method of diagnosing, monitoring, and staging prostate cancer: The present invention provides a new method for detecting, diagnosing, monitoring, staging and prognosticating prostate cancer.... Agent: Licata & Tyrrell P.C.

20100167284 - Nucleic acid size detection method: The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an optional second fragmentation, and identification using a marker sequence. In particular aspects, an expansion or reduction of tandem repeat sequences... Agent: Foley & Lardner LLP

20100167280 - Oligonucleotides for discriminating related nucleic acid sequences: An in vitro selection method is described which identifies oligonucleotide probes that discriminate amongst closely related nucleic acid sequences and which involves iterative hybridizations, including subtractive hybridization. Using the method, oligonucleotides are identified which can discriminate among human papilloma virus (HPV) subtypes. Corresponding methods and kits for the detection of... Agent: Goudreau Gage Dubuc

20100167299 - Phospholink nucleotides for sequencing applications: The present invention provides labeled phospholink nucleotides that can be used in place of naturally occurring nucleotide triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays, and others.... Agent: Morgan, Lewis & Bockius LLP (sf)

20100167286 - Pluripotent cell lines and methods of use thereof: Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100167275 - Potassium channel mutants of the yeast saccharomyces cerevisiae and their use for screening eukaryotic potassium channels: The invention relates to processes for identifying inhibitors and activators of eukaryotic potassium channels, in which a mutated S. cerevisiae cell is used whose endogenous potassium channels TRK1, TRK2 and TOK1 are not expressed functionally, but which expresses heterologously a eukaryotic potassium channel to be studied. Other subject matters of... Agent: Mdip LLC

20100167281 - Sequence analysis method: It is intended to provide an assay for the presence, absence or amount of a nucleic-acid fragment having a certain nucleotide sequence, for example, a polyA length, a difference in the number of repetition of a direct repeat sequence (e.g., microsatellite), single nucleotide substitution (or single nucleotide polymorphism), and nucleotide... Agent: Mattingly & Malur, P.C.

20100167303 - Sequences diagnostic for shrimp pathogens: Primers have been isolated that are diagnostic for the detection of Vibrio harveyi. The primers are based on a portion of the Vibrio harveyi LuxR gene and may be used in primer directed amplification or nucleic acid hybridization assay methods.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100167279 - Unsymmetrical cyanine dyes for high resolution nucleic acid melting analysis: The present invention relates to novel unsymmetrical cyanine dyes and to methods of performing nucleic acid analysis in the presence of such dyes. More specifically, the present invention relates to novel unsymmetrical cyanine dyes that have high affinity to double-stranded nucleic acids and that do not inhibit amplification reactions, particularly... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100167304 - Variable valve apparatus and methods: Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a... Agent: 3m Innovative Properties Company

20100167309 - Apparatus and method for analyte detection: Disclosed is a testing device and methods for the identification of an analyte of interest in a sample. In a preferred embodiment, the testing device includes a front panel having at least one sample application aperture; a rear panel having at least one solvent application aperture; a sample collection matrix... Agent: Foley & Lardner LLP

20100167308 - Method for measuring an analyte in blood: a second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20100167307 - Novel methods for the assay of troponin i and t and complexes of troponin i and t and selection of antibodies for use in immunoassays: s

20100167306 - Rapid test for glycated albumin in saliva: The test is performed using a disposable strip that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and presented in... Agent: Stetina Brunda Garred & Brucker

20100167314 - Control of intracellular target molecule by ip3 receptor-binding protein: The present invention provides a composition comprising an IP3 receptor-binding protein (IRBIT), a nucleic acid that controls the expression and translation of IRBIT, or an antibody against IRBIT for controlling at least one intracellular biological function selected from the group consisting of (1) protein synthesis, (2) phosphatidylinositol metabolism, and (3)... Agent: Foley And Lardner LLP Suite 500

20100167316 - Enrichment of tissue-derived adult stem cells based on retained extracellular matrix material: Methods for enriching, detecting, or using adult stem cells through the use of recognition ligands that specifically bind to ECM components retained to the surfaces of adult stem cells are described. An ECM component such as hyaluronan that is retained to the surfaces of adult stem cells when removed from... Agent: Pearne & Gordon LLP

20100167315 - Method for investigating the response to a treatment with a monoclonal antibody: The invention relates to steps for the development or the quality control of recombinant monoclonal antibodies (MoAbr) used as medicaments, and also to the selection of the patients liable to effectively respond to a treatment with a given monoclonal antibody. More specifically, the invention relates to a method for evaluating,... Agent: Morgan Lewis & Bockius LLP

20100167317 - Process for enriching basophils in a blood sample: The present invention is based on the discovery that contrary to prior studies CD16 is expressed by basophils and as such provide methods and kits for enriching basophils in a blood sample.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100167312 - Method for assaying a target analyte while reducing interference in an immunosensor system: a second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20100167311 - Oxidoreductases and processes utilising such enzymes: In Cu-containing nitrite reductase from Alcaligenes faecalis S-6 the axial methionine ligand of the type 1 site was replaced (M150G) to make the copper atom accessible to external ligands that might affect the enzyme's catalytic activity. The type-1 site optical spectrum of M150G (A460/A600=0.71) differs significantly from that of the... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100167310 - Reagent for measuring agglutination and method of measuring agglutination:

20100167313 - Anti-idiotype antibody against an antibody against the amyloid beta peptide: The present invention is directed to an anti-idiotype antibody binding to the complementary determining region of an antibody against the amyloid β peptide. In one embodiment said antibody binds to the same epitope or an overlapping epitope as the antibody obtainable from the cell line DSM ACC2939. Also reported is... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100167320 - Compositions and methods for detecting and quantifying toxic substances in disease states: The present invention relates to compositions comprising synthetic aggregated peptides (SAPs). The present invention also relates to the use of these SAPs as standards in methods for quantifying substances in a sample. The present invention also relates to methods of detecting, diagnosing and monitoring the progression of an abnormal condition... Agent: Life Technologies Corporation C/o Intellevate

20100167319 - Diagnose of mycobacterial infections by determination of ifn-gamma: The present invention provides a method for diagnosing a mycobacterial infection in a subject, involving the following steps: (i) collection of a sample from the subject; (ii) incubation of the sample from (i) with an antigen preparation for 12 hours or less; and (iii) analysis of γ-IFN in the sample... Agent: Marshall, Gerstein & Borun LLP

20100167321 - Epitope/peptide recognized by hla-a2402-restricted ep-cam-specific ctl and use of the same: A peptide consisting essentially of the amino acid sequence represented by SEQ ID NO:1; a peptide consisting essentially of the amino acid sequence represented by SEQ ID NO:2; or a mutant peptide consisting essentially of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:1... Agent: Sughrue Mion, PLLC

20100167318 - Fluidic structures including meandering and wide channels: The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analyses due to a reduction in sample and reagent quantities that are required, a reduction in the... Agent: Harvard University & Medical School C/o Wolf, Greenfield & Sacks, P.C.

20100167323 - Method for stabilization of proteins in solution: The present invention relates to a method for stabilization of analytes in solutions of solubilized body samples. The method comprises the steps of solubilizing the body samples obtained from a subject in a suitable sample medium and stabilizing said body sample contained within the sample medium by heating said sample... Agent: Howrey LLP-ca

20100167322 - Method of detecting cerebral stroke or asymptomatic cerebral infarction using acrolein, interleukin-6 and crp contents, polyamine oxidase activity or polyamine oxidase protein content and subject's age as indicators: A method of detecting cerebral stroke or asymptomatic cerebral infarction is disclosed. The method comprises measuring the contents of aldehyde compounds formed from polyamines, interleukin-6 and C-reactive proteins, the polyamine oxidase activity or the polyamine oxidase protein content in a biological sample obtained from a subject and using the measurement... Agent: Morris Manning Martin LLP

20100167324 - Quantitative assays for ras p21 in body fluids: The present invention is directed to the detection and quantification of total ras p21 in body fluids, particularly serial changes of total ras p21 levels in a subject's body fluids. Further, the invention is directed to detecting and quantitatiing total ras p21 in conjunction with one or more other proteins,... Agent: Siemens Corporation Intellectual Property Department

20100167325 - Methods for detecting risk of fatal prostate cancer using serum calcium: A method of screening for increased risk of fatal prostate cancer in a subject comprises providing a blood sample collected from the subject, and then detecting the presence or absence of an increased level of serum calcium in the sample. An increased level of serum calcium indicates the subject is... Agent: Myers Bigel Sibley & Sajovec

20100167326 - Method for cleavage of peptidic bond at c terminal of peptide and a method for determination of c terminal amino acid sequence of peptide: m

20100167327 - System for obfuscating identity: Compositions, apparatus, systems, kits, and methods for obfuscating the nucleic acid and/or protein content of an environment.... Agent: Searete LLC Clarence T. Tegreene

20100167328 - Blood cell separation: There is provided a method of isolating foetal cells from an isolated sample of maternal blood, the method comprising identifying cells having a different expression pattern of at least one foetal marker compared to the expression pattern of the marker in an equivalent maternal cell and selecting the identified cells,... Agent: Banner & Witcoff, Ltd.

20100167331 - Assessing risk of cardiac intervention in patients suffering from stable coronary heart disease based on gdf-15: Described is a method for diagnosing whether a percutaneous cardiac intervention (PCI) in a subject suffering from a stable coronary heart disease was successful, the method comprising determining the amount of GDF-15 in a first sample of the subject which has been obtained after PCI and comparing the determined amount... Agent: Roche Diagnostics Operations Inc.

20100167337 - Device for cell separation and analysis and method of using: A microflow device for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts which are arranged across the width of a collection region in an irregular or set random pattern so as... Agent: Cooley LLP Attn: Patent Group

20100167329 - Device for drug screening: The present invention discloses a device and an optical liquid sensor for drug screening, and a method for using these. More particularly a device, an optical liquid sensor, and a method, for repeatable measurements of the effect of a test drug on a biological tissue sample are described.... Agent: Merchant & Gould PC

20100167333 - Heavy metal binding compounds and their method of use: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of heavy metal ions in a sample. This metal chelating moiety is a —N,N,O-triacetic acid analog of BAPTA and has the following formula... Agent: Life Technologies Corporation C/o Intellevate

20100167332 - Induction of dendritic cell development with macrophage-colony stimulating factor (m-csf): A method of inducing dendritic cell (DC) development by administering Macrophage-Colony Stimulating Factor (M-CSF) is provided. M-CSF induces DCs to differentiate into Subtypes, for example plasmacytoid DCs and conventional DCs. Said differentiation is independent of Fms-like-Tyrosine- Kinase 3-Ligand (FL) and/or Granulocyte-Macrophage-Colony Stimulating Factor (GM-CSF). Induction with M-CSF can be achieved... Agent: Law Office Of Salvatore Arrigo

20100167335 - Methods for diagnosing and treating allergies: The present invention relates to methods of screening actives for the treatment of allergic reactions and providing treatment therefor. In particular, the invention relates to the screening of various antibacterial actives for treatment of asthma and other related symptoms.... Agent: Hoffmann & Baron, LLP

20100167330 - Micromechanical devices for control of cell-cell interaction, and methods of use thereof: The development and function of living tissues depends largely on interactions between cells that can vary in both time and space; however, temporal control of cell-cell interaction is experimentally challenging. By employing a micromachined silicon substrate with moving parts, herein is disclosed the dynamic regulation of cell-cell interactions via direct... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20100167336 - Parameter for x- and y- chromosome bearing sperm sorting with high degree of purity: Current invention is about the sex-specific separation of sperm in high purity. For more details, this invention is about the methods for improving the separation efficiency of sperm by removing factors deteriorating separation efficiency by utilizing several parameters and adjusting few conditions for the purpose of separating sperm into X-chromosome... Agent: Edwards Angell Palmer & Dodge LLP

20100167334 - Systems and methods for processing tissue samples for histopathology: A system for processing tissue biopsy samples during a histopathology process, including a tissue carrier constructed to carry a tissue biopsy sample during at least one step of the histopathology process, a database storing information associated with the tissue biopsy sample and associated with a tissue processing procedure, a machine-readable... Agent: Wood, Herron & Evans, LLP

20100167338 - Cassette for fixing, embedding and slicing biological tissues and method of using the cassette: A cassette for fixing, embedding and slicing biological tissues includes a base sheet and a lid sheet formed of an elongated plastic sheet which is sliceable and has not less than predetermined strength. The base sheet has grooves as biological tissue receiving portions. The base plate and the lid sheet... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100167339 - Process for microalgae conditioning and concentration: Conditioning and concentration of microalgae are accomplished by the process steps of grinding a dilute aqueous dispersion of microalgae in the presence of grinding media and then applying adsorptive bubble separation. This process is amenable to the use of dilute feed microalgal dispersions such as are encountered in the production... Agent: Phan Law Group PLLC

20100167340 - Method to produce a receptor chip using biotinylated protein: The present invention provides a method for detecting modified LDL, abnormal cells or bacteria using an intermolecular interaction analysis method, in which a region involved in ligand recognition by a receptor is expressed, without modification or as a biotinylated protein, in cells or in a test tube, and thereafter, the... Agent: Seed Intellectual Property Law Group PLLC

20100167345 - Halohydrin dehalogenases and related polynucleotides: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.... Agent: Dechert, LLP

20100167342 - Method of producing biologically active polypeptide having insulinotropic activity: The present invention relates to a method of producing a biologically active polypeptide having insulinotropic activity, the method comprising steps of: (a) transforming a genetically modified host cell that has protease gene knockout, with a polynucleotide vector encoding the polypeptide; and (b) growing the transformed host cell to produce the... Agent: Harness, Dickey & Pierce, P.L.C

20100167346 - Method of producing heterogeneous protein: e

20100167341 - Novel protein expression system: The present inventors devised a protein expression system with coexisting MiniSeV and SeV particles, and assessed the system for the ability to transfer a gene(s) of interest into target cells, and to express the gene(s) in the target cells. It was shown that the expression system of the present invention... Agent: Clark & Elbing LLP

20100167344 - Novel sialidases: The present invention relates to an isolated polypeptide which has sialidase activity, selected from the group consisting of: (a) a polypeptide which has an amino acid sequence which has at least 60% amino acid sequence identity with amino acids 1 to 407 of SEQ ID NO: 3; (b) a polypeptide... Agent: Nixon & Vanderhye, PC

20100167343 - Oviduct specific expression promoter and recombinant expression vector comprising the same: An oviduct specific expression promoter and a recombinant expression vector including the same. A promoter of an AGR2 gene is expressed specifically in the chicken oviduct, and a recombinant expression vector includes the promoter and a desired gene for encoding a desired protein. The oviduct specific promoter and the recombinant... Agent: Merchant & Gould PC

20100167347 - Compositions of aminoacyl-trna synthetase and uses thereof: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20100167348 - Peptide capable of binding to immunoglobulin: Disclosed are: a peptide capable of binding to an immunoglobulin; a fusion protein of the peptide; nucleic acids encoding the peptide and the fusion protein, respectively; production methods for the peptide and the fusion protein, respectively; a composition and a means for binding an immunoglobulin; a pharmaceutical composition for the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100167351 - Integrated methods for processing palm fruit bunches: This invention is directed to an integrated method for the processing of palm fruit bunches to oil and other products. The method comprises inter alia separating palm fruit carrying bunches into fruits and lignocellulosic empty fruit bunches, processing the fruits to form palm oil, and at least one lignocellulosic processing... Agent: Townsend And Townsend And Crew, LLP

20100167350 - Microorganism with ability to produce deoxy polyol dehydrogenase and use thereof: Means for Resolution: A microorganism belonging to genus Enterobacter with an ability to produce a dehydrogenase for deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol. The bacterial cell IK7 of the genus Enterobacter (accession No. NITE P-271). A method for... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100167349 - Orf11 from campylobacter jejuni is a sialate-o-acetyltransferase: The invention relates to sialate-O-acetyltransferase (SOAT) polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides.... Agent: Nada Jain, P.C.

20100167352 - Infectious clones: The present invention relates to methods of preparing a DNA comprising steps, wherein (a) a DNA comprising a full length copy of the genomic RNA (gRNA) or an RNA virus; or (b) a DNA comprising one or several fragments of a gRNA of an RNA virus, which fragments code for... Agent: Buchanan, Ingersoll & Rooney PC

20100167356 - Homologous recombination-based dna cloning methods and compositions: Methods and compositions for cloning a donor DNA molecule into an acceptor vector at a predetermined location are described. The methods are based on homologous recombination mediated by in vitro treatment of the donor DNA and the acceptor vector with an enzyme cocktail containing an exonuclease and a single-stranded DNA... Agent: Panitch Schwarze Belisario & Nadel LLP

20100167354 - Methods and compositions for amplification of rna sequences: The invention provides methods for isothermal amplification of RNA. The methods are particularly suitable for amplifying a plurality of RNA species in a sample. The methods employ a composite primer, a second primer and strand displacement to generate multiple copies of DNA products comprising sequences complementary to an RNA sequence... Agent: Wilson, Sonsini, Goodrich & Rosati

20100167355 - Microreactor with vent channels for removing air from a reaction chamber: A microreactor for performing chemical reactions, includes a body (2, 3), a first chamber (5) and a second chamber (7), both formed in the body (2,3). Interconnections (8) are provided for fluidly coupling the first chamber (5) and the second chamber (7) through the body (2, 3). The microreactor also... Agent: Tamsen Valoir, Ph.d. Baker & Mckenzie LLP

20100167353 - Rnase h-based assays utilizing modified rna monomers: The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3′ end of the oligonucleotide. These compounds offer an added level... Agent: John Petravich Integrated Dna Technologies, Inc.

20100167357 - Obligate heterodimer meganucleases and uses thereof: An obligate heterodimer meganuclease consisting of a first and a second monomer, deriving from two different homodimeric LAGLIDADG (SEQ ID NO: 66) endonuclease monomers (parent monomers), and having at least one pair of mutations interesting corresponding residues of said parent monomers which make an intermolecular interaction between the two monomers... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100167358 - Compositions and processes for improved plasmid dna production: Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity. These processes feature RNA based inducers of plasmid copy number.... Agent: Brooks Kushman P.C.

20100167359 - Methods for producing polyunsaturated fatty acid and lipid containing polyunsaturated fatty acid: A method for producing a polyunsaturated fatty acid (PUFA) or a lipid containing a PUFA, a microbial cell containing a PUFA, and use of the microbial cell are provided. A method for producing a polyunsaturated fatty acid (PUFA) or a lipid containing a PUFA including culture of a microorganism capable... Agent: Drinker Biddle & Reath (dc)

20100167360 - Process for heterogeneously catalysed preparation of carboxylic acid derivatives: Process for heterogeneously catalysed preparation of carboxylic acid derivatives using a reactor system comprising at least one reservoir vessel V, feed lines, at least one pump and a reaction vessel R, characterized in that a permanent gas flow through the reaction vessel R is applied through a gas feed line,... Agent: Frommer Lawrence & Haug

20100167361 - Non-revertible beta-oxidation blocked candida tropicalis: Genetically modified strains of C. tropicalis, which will not revert to wild-type activity at the POX 4 and/or POX 5 locus, are disclosed. The strains are β-oxidation blocked and have been transformed through homologous recombination with a construct which deletes a portion of the POX 4 and/or POX 5 gene.... Agent: Fox Rothschild LLP

20100167362 - Saponin-decomposing enzyme, gene thereof and large-scale production system for producing soyasapogenol b: The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce soyasapogenol B, a polynucleotide encoding such a protein, and a method of producing soyasapogenol B on a large scale using the same. A protein... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100167364 - Yeast with increased butanol tolerance involving cell wall integrity pathway: Increasing tolerance to butanol in yeast has been accomplished by increasing activity of the cell wall integrity pathway. Yeast with increased expression of SLT2p, a mitogen activated protein kinase of the MAPK module of the cell wall integrity pathway had increased tolerance to isobutanol. These yeast may be used for... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100167363 - Yeast with increased butanol tolerance involving filamentous growth response: Increasing tolerance to butanol in yeast has been accomplished by increasing activity of the filamentous growth response. Yeast with increased expression of MSS11p, a transcriptional activator of the filamentous growth response pathway had increased tolerance to isobutanol. These yeast may be used for improved butanol production.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100167365 - Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway: Increasing tolerance to butanol in yeast has been accomplished by increasing activity of the high osmolarity/glycerol response pathway. Yeast with increased expression of PBS2p, a mitogen activated protein kinase kinase of the MAPK module of the high osmolarity/glycerol response pathway may be used for improved butanol production.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100167366 - Pumping and contamination control system for cellulosic feedstocks: Processes for the pumping of various cellulosic feedstock materials that are used to produce an ethanol-containing beer are disclosed. In certain embodiments, the present invention relates to processes capable of pumping highly viscous slurries and/or feedstocks containing high levels of solids in an energy efficient manner, wherein the slurries of... Agent: Fleit Gibbons Gutman Bongini & Bianco P.l.

20100167367 - Ethanol recovery system for cellulosic feedstocks: Processes for the recovery of ethanol, useful as a fuel, from various cellulosic feedstock materials fermented to produce ethanol-containing beer are disclosed. The present invention provides means for ethanol recovery from highly viscous fermented citrus waste biomass. The systems overcome various challenges, including effectively stripping the ethanol from biomass beer... Agent: Fleit Gibbons Gutman Bongini & Bianco P.l.

20100167368 - Process for production of monosaccharide and process for production of ethanol both utilizing cellulose-based substance: Disclosed is a novel process which has low facility load, requires a reduced amount of energy, is highly safe, and enables to produce a monosaccharide such as glucose and xylose by decomposing a cellulose-based substance under conditions where a substance used for decomposing the cellulose-based substance (e.g., a solvent, a... Agent: Conley Rose, P.C. David A. Rose

20100167369 - Biomass as a sustainable energy source: Methods and systems for increasing the generation of methane from a biomass are disclosed. In some embodiments, the method includes the following: decomposing a biomass to produce an gaseous effluent including methane; decomposing a portion of the gaseous effluent in the presence of catalysts to form a decomposed stream including... Agent: Wiggin And Dana LLP Attention: Patent Docketing

20100167370 - Reduction of carbon dioxide emission during isoprene production by fermentation: The present invention provides methods for increasing the amount of isoprene produced by cultured cells with only a minimal increase in carbon dioxide emitted, thereby resulting in process having a greater yield of isoprene relative to carbon dioxide. In addition, the present invention provides compositions that include the cultured cells... Agent: Morrison & Foerster LLP

20100167371 - Systems using cell culture for production of isoprene: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells. The invention provides isoprene compositions, such as compositions with increased amount of isoprene or increased purity. Additionally, the invention provides methods of producing isoprene by culturing cells under conditions suitable... Agent: Morrison & Foerster LLP

20100167372 - Device and method for separation, concentration, and/or purification of cells: The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive... Agent: Hodgson Russ LLP The Guaranty Building

20100167373 - Pouch-like construct for preventing heart distension: The invention is directed to a pouch-like construct comprising mammalian tissue which can be used for preventing distension and/or resisting dilation of the heart in a mammal. Preferably, the pouch-like tissue construct has contractile properties. The invention further relates to a method for the preparation of a pouch-like construct comprising... Agent: Marshall, Gerstein & Borun LLP

20100167375 - Novel lipolytic enzyme lip2: The present invention provides a novel nucleic acid sequence, designated LIP2, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for... Agent: Janet Kaiser Castaneda Genencor International, Inc.

20100167374 - Ultra-fast chromatography: The present invention relates to a chromatographic method of separating biological material comprising, providing chromatographic media comprising inorganic oxide particles having an average diameter of about 2 microns or less and an average pore diameter of 300 Å or more; applying a solvent comprising said biological material to said media,... Agent: Alltech Associates, Inc.

20100167376 - Methods for providing cellular lysates from cell wall-containing samples: The present invention provides methods useful for making lysates from cell wall-containing cellular samples, including plant tissue samples and cultures of yeast or bacteria. The invention further provides compositions (e.g., solutions) that can be used in the methods of the invention, and kits comprising solutions and/or other reagents useful for... Agent: Cooley LLP Attn: Patent Group

20100167377 - Recombinant viruses comprising the membrane-proximal domain of vsv g protein: Recombinant viruses, isolated nucleic acids and methods of generating same encoding for a Rhabdoviral G stem polypeptide are disclosed. Methods, compounds and compositions for target cell fusion potentiation mediated by Rhabdoviral G stem polypeptides, and applications of same are provided.... Agent: Pearl Cohen Zedek Latzer, LLP

20100167378 - Preparation of virally inactivated biological fluids having high alpha-2-antiplasmin activity: The invention relates to the use of polyoxyethylene (4-5) p-t-octyl phenol (t-Oct-C6H4—(OCH2CH2)x0H, x=˜5) or polyoxyethylene (20) sorbitan monooleate in solvent/detergent viral inactivation of biological fluids for the preparation of a virally inactivated biological fluid having a high alpha 2-antiplasmin content.... Agent: Young & Thompson

20100167379 - Bacteria for high efficiency cloning: Disclosed are novel bacterial hosts that are capable of high efficiency transformation with methylated and/or unmethylated nucleic acids, and that are bacteriophage resistant. Such bacteria contain: (1) an F′ episome that confers high efficiency transformability; (2) one or more mutations that allow transformation of methylated nucleic acids; (3) one or... Agent: Life Technologies Corporation C/o Intellevate

20100167380 - Process for the production of organic formulation of bio-pesticide pseudomonas fluorescens: This invention relates to a process for the production of organic formulation of bio pesticide containing Pseudomonas Fluorescens comprising preparation of Mother culture of P. fluorescens and inoculating in King's B broth, at 30±1° C. for 24-36 hours followed by liquid fermentation process in 5-10% pongamia cake aqueous extract, 5-10%... Agent: The Webb Law Firm, P.C.

20100167381 - Photo bioreactor with light distributor and method for the production of a photosynthetic culture: The invention provides a photo bioreactor (1) comprising a vessel (10) containing an aqueous liquid comprising a photosynthetic culture and a light distributor (30). The light distributor has a surface (31) arranged to receive light (40) and a tapered surface (32) arranged to emit at least part of the received... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100167382 - Method and device for the formation of biological cell material: A manipulation tool is disclosed for producing cell material having multiple biological cells, which have a predefined geometrical arrangement. The tool includes a tool body, whose surface at least partially contacts the cell material, and a setting device for adjusting the tool body by a continuous expansion, so that geometrical... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20100167383 - Culture apparatus: A culture apparatus comprising: a housing including a culture chamber inside, culture being cultured in the culture chamber; a door configured to seal the culture chamber; an ultraviolet lamp configured to generate an ultraviolet ray for disinfecting air in the culture chamber; a lighting device configured to allow the ultraviolet... Agent: Osha Liang L.L.P.

20100167384 - Microfluidic mixing and analytical apparatus: Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the... Agent: Seed Intellectual Property Law Group PLLC

20100167385 - User interface features for an electronic device: A method is provided for controlling a display device of an electronic device. A data field may be displayed on the display device. An editing process may be executed that provides for editing of the data field displayed on the display device. The data field on the display device may... Agent: Roche Diagnostics Operations Inc.

20100167386 - Immunosensor system for blood with reduced interference: a second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20100167387 - System and automated device for analysing a cell suspension: A system for analyzing a cell suspension includes at least one well for decanting (1) the suspension and elements (2, 3) for analyzing the cell deposits at the bottom of the well over time during the decanting, so as to allow an analysis of the cells by strata (T1, T2,... Agent: Young & Thompson

20100167388 - Single use centrifuge system: An improved centrifuge system having a single means for both feeding and collecting liquid streams aseptically from rotating components is provided. Also methods and apparatus for centrifugal separation of cells from cell culture media of large cell culture batches by processing a large volume within a few hours, using pre-sterilized,... Agent: Walker & Jocke, L.p.a.

20100167389 - Synthetic expression vectors for insect cells: The present invention is directed at optimized expression vectors for the expression of native-like heterologous proteins in insect cells. Compositions of the invention are nucleotide sequences representing elements of an expression vector that when combined results in enhanced expression and secretion of heterologous proteins. The elements include sequences that define... Agent: George E. Darby

20100167392 - Factor viii compositions and methods: The present invention provides methods of increasing the half-life and/or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and/or specific activity of factor VIII by substituting one or more amino acids in the A2 domain. It further provides methods for producing such factor... Agent: Sughrue Mion, PLLC

20100167391 - Growth factor homolog zvegf3: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the... Agent: Townsend And Townsend And Crew LLP

20100167393 - Modified human thymic stromal lymphopoietin: Modified, furin resistant human TSLP polypeptides and polynucleotides encoding the modified human TSLP polypeptides are provided. Pharmaceutical compositions, B and T cell activation agents, assays and methods of use are also described.... Agent: Immunex Corporation Law Department

20100167390 - Novel oligonucleotide and nf-kb decoy comprising the same: A novel oligonucleotide useful as an NF-κB decoy having a higher binding ability to NF-κB than known NF-κB decoy as well as the medical uses thereof, is disclosed. The oligonucleotide of the invention has a base sequence having a consensus sequence and specific 5′-flanking and 3′-flanking sequences ligated to both... Agent: Law Office Of Michael A. Sanzo, LLC

20100167394 - Ultramarine fluorescent protein: The present invention provides an artificial mutant of GFP having a novel emission peak, i.e., a fluorescent protein having an emission peak at 424 nm comprising an amino acid sequence represented by SEQ ID NO: 1, in which each of the amino acid residues at the 66th position and the... Agent: Foley And Lardner LLP Suite 500

20100167396 - Application of anti-apoptotic gene expression in mammalian cells for perfusion culture: The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell expressing recombinant Factor VIII such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of recombinant Factor VIII by... Agent: Bayer Healthcare LLC

20100167395 - Humanized gm-csf antibodies: Chimeric antibodies, as well as fusion proteins which comprise chimeric antibodies, are disclosed. The antibodies bind to GM-CSF, CD-30, and G250 antigen. The fusion proteins include biologically active portions of tumor necrosis factor, or full length tumor necrosis factor. Expression vectors adapted for production of the antibodies, as well as... Agent: Fulbright & Jaworski, LLP

20100167397 - Endocrine cell lines and method of using the same: In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or... Agent: Nixon & Vanderhye, PC

20100167398 - Method of culturing pluripotent stem cells using extracellular matrix from fetal membrane-derived cells: Provided are a method of culturing pluripotent stem cells in the presence of a decidua-derived cell or an extracellular matrix derived from the cell, that enables safe and efficient maintenance culture and derivation of pluripotent stem cells; a culture agent for pluripotent stem cells, that comprises a decidua-derived cell or... Agent: Leydig Voit & Mayer, Ltd

20100167399 - Method of generating regulatory t cells using cord blood and adult blood cd14+ monocyte cells: A method of inducing stable and functional Tregs from human umbilical cord blood and adult blood without requiring the expansion of pre-existing Tregs. The method utilizes CD14+ monocyte cells present in or isolated from cord blood or adult blood to induce functional Tregs from T cells, and particularly T cells... Agent: Hartman & Hartman, P.C.

20100167400 - Composition for increasing intracellular nitric oxide and method for the same: A composition and a method for increasing intracellular nitric oxide is provided. The composition comprises a far-infrared ray releasing substance composed mainly of an oxide mineral for releasing a far-infrared ray, wherein the composition promotes generation of the nitric oxide via irradiation of the far-infrared ray from the far-infrared ray... Agent: Haverstock & Owens LLP

20100167401 - Stacked, patterned biomaterials and/or tissue engineering scaffolds: Stacked, lamellar constructs comprised of, synthetic or natural, polymeric membrane structures which are brought together to form 3D scaffolds for biomaterial and guided tissue engineering applications have been developed. Each layer can have 2D or 3D nano and micro topographical features similar to or different than each other which can... Agent: Collen Ip

20100167402 - Human serum for cell culture: It is intended to provide a serum which contains a large amount of growth factors capable of efficiently promoting the growth of stem cells. A human serum for cell culture which shows a residual ratio of platelets remaining within 20 minutes after blood collection in relation to the whole amount... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20100167403 - Identification and selection of commercial-quality transgenic plant events: A method for identifying and selecting commercial-quality transgenic plant event from a set of transgenic plant events includes determining a desired set of characteristics for the product, identifying data for assessing the desired set of characteristics, forming a staged experimental plan for generating the data, and executing the staged experimental... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pioneer Hi-bred

20100167404 - Methods of reprogramming animal somatic cells: This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to... Agent: Ropes & Gray LLP

20100167405 - Processes for improved strain engineering: Improvements in strain engineering technology are needed to insure the economic feasibility of future engineered recombinant organisms for industrial biotechnology. Disclosed herein are rapid, efficient methods (Genome Mass Transfer) that facilitate introduction of new selectable traits into a target microbial host. In one preferred embodiment, methods for high efficiency electroporation... Agent: Brooks Kushman P.C.

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