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Chemistry: molecular biology and microbiology June invention type 06/10

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
06/24/2010 > patent applications in patent subcategories. invention type

20100159444 - Devices for the detection of multiple analytes in a sample: The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.... Agent: King & Spalding LLP

20100159443 - Disease model incorporation into an artificial immune system (ais): The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endothelial cells, and diseased cells. The artificial immune system of the present invention can be used for... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100159442 - Magnetic recognition system: Provided is a label for an analyte, which label is attached to a magnetic or magnetizable substance, the label comprising: (a) a recognition moiety for attaching the label to the analyte; and (b) a moiety for binding or encapsulating the magnetic or magnetizable substance; wherein the moiety for binding or... Agent: Knobbe Martens Olson & Bear LLP

20100159439 - Method for combined sequential agent delivery and electroporation for cell structures and use thereof: Disclosed is a method for sequential delivery of agents to and/or into a cell structure, wherein an electrolyte-filled tube is provided together with a counter electrode, said tube is connected to a voltage or current generator, at least two agents are introduced in a discrete mode into the electrolyte solution... Agent: Edwards Angell Palmer & Dodge LLP

20100159440 - Methods for identifying agents that modulate p44: The present invention provides methods for identifying evolutionarily significant polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a physiological condition, such as enhanced resistance to HCV infection. The invention also provides methods for identifying evolutionarily significant polynucleotides with mutations that are correlated with susceptibility... Agent: Swanson & Bratschun, L.L.C.

20100159441 - Multi-wavelength analyses of sol-particle specific binding assays: The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100159469 - Compositions and methods for breast cancer prognosis: The present invention provides novel compositions and their use in classifying breast tumors.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100159449 - Continuous assay method for measuring receptor- and ion channel-mediated calcium response and subsequent gene expression: To measure a receptor-mediated increase in intracellular calcium concentration, use is made of a calcium-responding luminescent protein localized in the cytoplasm or mitochondria and a reporter gene having a promoter responding to the second messenger in cells and Renilla-origin luciferase attached to the downstream thereof. By using a coelenterazine derivative,... Agent: Judge Patent Associates

20100159446 - Detection assays and use thereof: The invention provides compositions and methods for the detection and/or quantification of biological targets (e.g., nucleic acids and proteins) by the nucleic acid-templated creation of one or more reaction products, for example, epitopes, enzyme substrates, enzyme activators, and ligands. The reaction products can be detected and/or quantitated after signal amplification... Agent: Goodwin Procter LLP Patent Administrator

20100159450 - Dpyd gene variants and use thereof: Variants in DPYD gene are disclosed which can result in abnormal synthesis of DPD proteins and alteration of DPD activities. The invention provides methods for detecting the newly discovered genetic variants. The DPD genetic variants of the invention can be used as biomarkers in predicting toxicity to 5-FU and other... Agent: Myriad Genetics Inc. Intellectual Property Department

20100159463 - Fast results hybrid capture assay and system: The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100159453 - Genes involved in intestinal inflammatory diseases and use thereof: The invention concerns genes involved in inflammatory and/or immune diseases and some cancers, in particular intestinal cryptogenic inflammatory diseases, and proteins coded by said genes. The invention also concerns methods for diagnosing inflammatory diseases.... Agent: Townsend And Townsend And Crew, LLP

20100159454 - Htsnps for determining a genotype of cytochrome p450 1a2, 2a6 and 2d6, pxr and udp-glucuronosyltransferase 1a gene and multiplex genotyping methods using thereof: The present invention relates to htSNPs for determining a genotype of cytochrome P450 1A2 (CYP1A2), 2A6 (CYP2A6) and 2D6 (CYP2D6), PXR and UDP-glucuronosyltransferase Ia (UGT1A) genes and a gene chip using the same, and more particularly, to a selection method of htSNPs for determining a haplotype of human CYP1A2, CYP2A6,... Agent: LexyoumeIPGroup, LLC

20100159461 - Ion sensitive field effect transistors: According to a first aspect of the present invention there is provided a digital signal processing circuit, one or more switches of the circuit being provided by an ion sensitive field effect transistor.... Agent: Nixon & Vanderhye, PC

20100159460 - Isolation of nucleic acids on surfaces: New processes and equipment to isolate and purify nucleic acids on surfaces are provided. The invention focuses on processes which use surfaces, for example, porous membranes, on which the nucleic acids are immobilized in a simple manner from the sample containing the nucleic acids and can be released again by... Agent: Fanelli Strain & Haag PLLC

20100159452 - Method for detecting a target nucleic acid in a sample: The invention relates to a method for detecting a target nucleic acid in a sample using fluorescent probe pairs which include fluorescent reporter and quencher molecules which may be used in hybridization assays and in nucleic acid amplification reactions, especially polymerase chain reactions (PCR).... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100159448 - Method for detection and multiple, simultaneous quantification of pathogens by means of real-time polymerase chain reaction: A method for the detection and multiple, simultaneous quantification of any combination of Listeria sp., Staphylococcus aureus, Campylobacter jejuni and/or Escherichia coli O157.-H7, in one or more test samples, by multiplex amplification reaction, using real-time polymerase chain reaction (PCR). The steps in the method are: (a) extracting DNA from the... Agent: Michael Winfield Goltry

20100159464 - Method for detection of dna methyltransferase rna in plasma and serum: The methods of the invention detect in a qualitative or quantitative fashion DNA methyltransferase RNA in blood plasma, serum, and other bodily fluids. The inventive methods are useful for aiding detection, diagnosis, monitoring, treatment, or evaluation of neoplastic disease, and for identifying individuals who might benefit from therapeutic approaches that... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100159458 - Method for predicting the response to a therapy: The present invention relates to cancer treatment and particularly to a method for predicting the response of a cancer subject to a given therapy. The invention provides a gene or gene product useful as a predictive marker for classifying the subjects. Also disclosed are diagnostic tools, test kits and compositions... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100159467 - Method for replicating the hepatitis c virus: A process for screening anti-HCV agents, including the steps of introducing a compound to be tested for its anti-HCV properties with transformed Vero/6418 cells, having a nucleic acid selected from the group consisting of a nucleic acid coding for the structural and non-structural proteins of the HCV, a nucleic acid... Agent: Young & Thompson

20100159445 - Method for the individual staging of tumor diseases: The present invention concerns a method for the individual staging of the tumor disease of an individual cancer patient, a method for the individual decision on the method of treatment as well as a method for treating a cancer patient as well as their use in the treatment of various... Agent: Fulbright & Jaworski L.L.P.

20100159451 - Method of detecting interaction between nucleic acid and protein, and apparatus for the same: The invention is to easily detect an interaction between nucleic acid and protein with high sensitivity without the need of sample labeling with a fluorescent molecule or sample anchorage onto a metal thin-film. As means for it, the presence or absence of occurrence of the interaction between nucleic acid and... Agent: Reed Smith L.l.p

20100159456 - Methods for detecting tcr-gamma gene rearrangement: The invention provides methods for detection of TCR-γ nucleic acid in acellular body fluid. The methods can be used to detect the TCR-γ gene rearrangement in acellular body fluid. The detection of TCR-γ gene rearrangement is useful in determination of clonality of T-cell population. The invention is useful in the... Agent: Foley & Lardner LLP

20100159459 - Production of reprogrammed cells with restored potential: A method for treating cells and/or nuclear transfer units and/or stem cells in culture with such compounds, individually or in combinations, is described. The method results in a globally hypomethylated genome and a restoration of cell differentiation and/or developmental potential, or potentiality. In addition, a method for the in vitro... Agent: Whyte Hirschboeck Dudek S.c. Intellectual Property Department

20100159447 - Quantitative amplification with a labeled probe and 3' to 5' exonuclease activity: This invention provides methods and kits for performing a quantitative amplification reaction. The method employs a polymerase enzyme and an enzyme having a 3′ to 5′ exonuclease activity that cleaves the 3′ oligonucleotide of the probe.... Agent: Townsend And Townsend And Crew, LLP

20100159455 - Receptor family profiling: The invention provides compositions and methods, e.g., assay technologies and their use in biodetection and diagnostics. More particularly, the invention provides compositions and methods based on nucleic acid-templated chemistry in biodetection and profiling of receptors (and their families) and proteins (and their families), and the use of same in diagnostics.... Agent: Goodwin Procter LLP Patent Administrator

20100159470 - Scds as modifiers of the p53 pathway and methods of use: Human SCD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SCD are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20100159465 - Screening of abundantly secreted proteins and their use as fusion partners for the production of recombinant proteins: The present invention relates techniques for identifying suitable secretion fusion partner (SFP) for hyper-secretory production of recombinant proteins. The SFPs can be obtained from secretome analyses. Recombinant proteins are produced in a fusion form with a secretion fusion partner (SFP) and can be separated from the SFP by in vitro... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100159468 - Small molecule inhibition of intracellular transport: The present disclosure characterizes the activity of Golgicide A (GCA), as a potent, specific and reversible small molecule inhibitor of Golgi BFA resistance factor 1 (GBF1) function. A mutant GBF1 gene that is resistant to GCA is also described. Methods of using GCA and the GCA-resistant GBF1 gene are described... Agent: Polsinelli Shughart PC

20100159457 - System and method for presenting dna binding specificities using specificity landscapes: A system and method for analyzing DNA binding specificities is provided. The potential binding motifs are compared to a plurality of DNA sequences. The DNA sequences are plotted within a specificity landscape, which provides details otherwise unavailable, relating to binding affinities and binding specificities of the motif-sequence combination.... Agent: Michael Best & Friedrich LLP

20100159466 - Targets for use in diagnosis, prognosis and therapy of breast cancer: The invention is directed to methods of diagnosing breast cancer, susceptibility to breast cancer, nodal metastasis of a breast cancer and screening for breast cancer in an individual in need thereof comprising detecting the presence of a loss of heterozygosity/allelic imbalance (LOH/AI) at one or more specific loci (markers) in... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100159462 - Tunable elastomeric nanochannels for nanofluidic manipulation: The invention relates to tunable elastomeric nanochannels for nanofluidic manipulation. In particular, the present invention relates to nanochannels for performing biological assays.... Agent: Casimir Jones, S.c.

20100159476 - Device and method for detecting the presence of hemoglobin in a biological sample: A device and method for detecting the presence of hemoglobin in a biological sample, more particularly, the presence of blood in a fecal sample as an indicator of upper or lower gastrointestinal tract bleeding.... Agent: Foley & Lardner LLP

20100159472 - Method for diagnosing multiple sclerosis: Disclosed is a method for diagnosing and prognosing multiple sclerosis and more particularly to a method for diagnosing and prognosing multiple sclerosis by measuring levels of antibodies. The levels of IgM-type anti-Glc(α1,2)Glc(α) or Glc(α1,3)Glc(α) or Glc(α1,6)Glc(α) antibodies in serum act as diagnostic markers for MS disease and as prognostic biomarkers... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100159475 - Methods for determination of calcineurin activity and uses in predicting therapeutic outcomes: The methods of the disclosure provide fluorescence-based assays for calcineurin activity, especially in isolated T cells. The methods include the stimulation of the T cells with agents that specifically target the TCR with or without influencing co-stimulatory pathways. One TCR agonist is monoclonal antibodies specific for CD3, which more precisely... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100159473 - Peptide standards: The invention relates to methods for making a peptide standard for mass spectrometry said method comprising (a) identifying endopeptidase cleavage sites in a parent polypeptide sequence of interest; (b) selecting peptide sequences from said parent polypeptide which are defined by endopeptidase cleavage sites of step (a); (c) adding a C-terminal... Agent: Mcandrews Held & Malloy, Ltd

20100159471 - Process for production of colloidal gold and colloidal gold: It is an object of the present invention to provide a method for producing gold colloid having a targeted particle size, a sharp particle size distribution and a uniform and perfect spherical shape. The present invention relates to a method for producing gold colloid including a nucleation step of forming... Agent: Roberts & Roberts, LLP Attorneys At Law

20100159474 - Prognosis and risk assessment in patients suffering from heart failure by determining the level of adm and bnp: The present invention relates to a method for prognosis of an outcome or assessing the risk of a patient suffering from heart failure and/or shortness of breath, comprising the determination of the levels of ADM or fragments thereof or its precursor or fragments thereof and BNP or fragments thereof or... Agent: Millen, White, Zelano & Branigan, P.C.

20100159484 - Chemotaxis diagnostic: A method is described for determining the chemotactic activity of leukocytes in a sample, in which method the expression of a cell adhesion molecule is determined.... Agent: Fulbright & Jaworski, LLP

20100159485 - Detection of mycobacterium tuberculosis: The present technology relates generally to the use of an Rv1168c polypeptide, or fragments thereof, or Rv1168c polypeptide binding agent for detecting or diagnosing exposure to Mycobacterium tuberculosis as well as detecting or diagnosing Mycobacterium tuberculosis infection in a mammal.... Agent: Foley & Lardner LLP

20100159478 - Biomarkers for chronic vascular dysfunction: Materials and methods for using biomarkers to determine prognosis and response to treatment in subjects having chronic vascular dysfunction.... Agent: Fish & Richardson P.C.

20100159480 - Biosensors, method for obtaining the same and uses thereof: The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100159481 - Detection of hypertension using glucuronidated metabolic products: A method of assessing arachidonic acid (AA) metabolites-dependent hypertension by measuring glucuronidated dihydroxyeicosatrienoic acids (DHETs) and DHET metabolites in a biological sample which contains the epitopes unique to DHET (using any methods including GC/MS, LC/MS or ELISA). An example of the glucuronidated DHET metabolite is DHET-alcohols such as omega or... Agent: Kohn & Associates, PLLC

20100159477 - Reagents for the detection of protein phosphorylation in signaling pathways: The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100159479 - Timp-1 as a marker for colorectal cancer: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein TIMP-1 (tissue inhibitor of metalloproteinase 1) as a marker molecule in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual,... Agent: Roche Diagnostics Operations Inc.

20100159482 - Proteinase k inhibitors, methods and compositions therefor: The synthesis, biological evaluation, and molecular modeling of alkoxysuccinyl-peptidyl-haloalkyl ketones for use as proteinase K inhibitors are described. Sample preparation processes for in situ RNA or DNA analysis using such inhibitors, methods and compositions therefor are provided.... Agent: Life Technologies Corporation C/o Intellevate

20100159483 - Article for assaying target, comprising solid surface on which first binding member, blocking material, and second binding member are immobilized, and use thereof: Disclosed are an article for assaying a target, wherein the article includes a solid surface on which a first binding member, a blocking material, and a second binding member are immobilized, a method of manufacturing the article, and a method of detecting a target using the article.... Agent: Sughrue Mion, PLLC

20100159487 - Assay system: An assay apparatus comprising: i) an assay cartridge (52, 53) comprising at least one well (57-62) and a pipette (50) positionable in at least one said well; ii) a holder arranged to receive said cartridge; iii) drive means operable to position said pipette in selected wells of said cartridge; iv)... Agent: Bacon & Thomas, PLLC

20100159486 - Biomarkers for neurological conditions: Low molecular weight (LMW) peptides have been discovered that are indicative of neurological conditions, such as Alzheimer's Disease (AD), cognitive impairment and brain microhemmorhages. Evaluating patient samples for the presence of such LMW peptides is an effective means of detecting neurological conditions and monitoring the progression of the disease. The... Agent: Foley And Lardner LLP Suite 500

20100159488 - Method for the multiplex serological diagnosis in vitro of spirochete infections: A method for the serological diagnosis, in vitro, of an infection with a spirochete bacterium which is pathogenic in humans, chosen from bacteria of the Borrelia, Leptospira and Treponema genera, by carrying out at least one of 1) an assay of IgG-type and/or IgM-type antibodies against at least one tick-borne... Agent: Dennison, Schultz & Macdonald

20100159490 - Multiplexed assay methods: The present invention is directed to methods for conducting multiplexed assays. The methods are particularly well suited for measuring a plurality of analytes that may be present in very different abundances. The invention also relates to systems, devices, equipment, kits and reagents for use in such methods.... Agent: Scully, Scott, Murphy & Presser, P.C.

20100159489 - Promoter: The current invention reports a promoter having the nucleic acid sequence of SEQ ID NO: 02, or SEQ ID NO: 03, or SEQ ID NO: 04, or SEQ ID NO: 06, which is a 5′ shortened SV40 promoter with reduced promoter strength especially useful for the limited expression of heterologous... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100159491 - H-fabp as early predictor of myocardial infarction: The present invention relates to a method for diagnosing myocardial infarction in a subject who suffers from acute coronary syndrome and has a cardiac troponin level which is detectable but lower than the level that is considered as being indicative for a myocardial infarction. Moreover, the present invention relates to... Agent: Roche Diagnostics Operations Inc.

20100159492 - Method for the diagnosis of diseases by determining apolipoprotein c-1: A method for the diagnosis, early detection, risk estimation and control of the course of diseases, wherein the amount of apolipoprotein C-I and/or derivatives thereof is determined in a serum or plasma sample from a human patient and it is possible to conclude as to the presence of a disease,... Agent: Heslin Rothenberg Farley & Mesiti PC

20100159494 - Methods for determining cellulolytic enhancing activity of a polypeptide: The present invention relates to methods for determining cellulolytic enhancing activity of a polypeptide, comprising: (a) incubating a cellulosic material with an enzyme composition comprising a cellobiose dehydrogenase and one or more (several) cellulolytic enzymes in the presence and absence of the polypeptide; and (b) measuring the release of sugar... Agent: Novozymes, Inc.

20100159493 - Methods of quantifying methotrexate metabolites: The present invention provides a method for efficiently converting methotrexate polyglutamates to methotrexate in a cellular extract by contacting the cellular extract with gamma glutamyl hydrolase under conditions suitable for efficient conversion of methotrexate polyglutamates to methotrexate.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100159495 - Prosecc an means for enzymatic determination of acetate: The invention relates to a method and means for the enzymatic determination of acetate. The method according to the invention facilitates for the first time reflectometric detection by means of a test strip.... Agent: Millen, White, Zelano & Branigan, P.C.

20100159497 - Binned micro-vessel density methods and apparatus: In one aspect, a method of obtaining micro-vessel density (MVD) measurements from an image of biological vasculature containing a plurality of vessels is provided. The method comprises acts of analyzing a region of interest of the image for each of a plurality of bins, each of the plurality of bins... Agent: Wolf Greenfield & Sacks, P.C.

20100159498 - Blood analyzer with a blood cell sedimentation control mechanism and method of use: A blood analyzer having a blood cell sedimentation control mechanism is disclosed, which includes a cassette receiving interface including a cassette compartment and a blood sensor operable to detect a presence of blood in a disposable cassette removably disposed within the cassette compartment; a system control electrically connected to the... Agent: Latimer & MayberryIPLaw, LLP

20100159503 - Enhanced processes for drug testing and screening using tissue samples: A method for testing human tissue in a testing system is more effective than conventional cell culture systems and functions by treating the human tissue slice system's samples with at least one compound and observing the effect on the human tissue slices resident therein, or cells, tissue samples or other... Agent: Greenberg Traurig LLP (la)

20100159496 - Evaluation method for photosynthesis sample, evaluation system for photosynthesis sample, and evaluation program for photosynthesis sample: An evaluation method for photosynthetic sample according to the present invention is for evaluating a state of a photosynthetic sample with a photosynthetic function based on temporal data of a luminescence amount of delayed luminescence emitted from the photosynthetic sample. First, characteristic values that indicate characteristics are determined for a... Agent: Drinker Biddle & Reath (dc)

20100159502 - Method and apparatus for environmental monitoring and bioprospecting: A method for environmental monitoring and bioprospecting includes the steps of: (a) utilizing a testing device having: (i) a container having a fluid inlet and outlet, (ii) a plurality of capillary microcosms situated within the container, each of these capillaries having an inlet and outlet that are configured so as... Agent: Edwards Angell Palmer & Dodge LLP

20100159500 - Method for determining the haemolysis of a blood sample and device: The invention relates to a method for determining the haemolysis of a blood sample during which the haemolysis progress is determined, wherein the method comprises the steps of irradiating measuring light which is radiated from a measuring light source on the blood sample during haemolysis; detecting measuring light values at... Agent: Roche Diagnostics Operations Inc.

20100159501 - Method for quantification of cellular sphingolipids: A method is provided for quantifying endogenous sphingolipids in a biological system. The method includes preparing one or more isotope labeled amino acids; introducing the isotope labeled amino acids into a biological system; extracting and separating a sphingolipid-containing fraction from the biological system; and quantifying the amount of endogenous sphingolipids... Agent: Sutherland Asbill & Brennan LLP

20100159499 - Nanoparticulate cell culture surface: where (x), (y), (z), R, R′, R″, S, W, and X, are as defined herein. Methods for making the cell culture article or cell culture article and methods for performing an assay of a ligand with the article are also disclosed.... Agent: Corning Incorporated

20100159504 - Integrated microbial collector: A system for real-time sizing of fluid-borne particles is disclosed. The system further determines, in real time, whether the detected particles are biological or non-biological. As the fluid is being tested, it is exposed to a microbe collection filter which is cultured to determine the type of microbes present in... Agent: Quarles & Brady LLP

20100159505 - Real-time monitoring of age pigments and factors relating to transmissible spongiform encephalopathies and apparatus: A fluorescent spectroscopic method and apparatus for real time direct detection of transmissible spongiform encephalopathies in central nervous system tissue by monitoring the fluorescence of intrinsic markers in the tissue by illuminating the tissue with UV or visible light having an appropriate wavelength, and the resulting emission spectra is detected... Agent: Erickson, Kernell, Derusseau & Kleypas, LLC

20100159506 - Methods and systems for genetic analysis of fetal nucleated red blood cells: Methods for determining genetic status of a fetus from a sample of maternal blood comprise enriching nucleated red blood cells in the sample, including both fetal and maternal nucleated red blood cells. The nucleated red blood cells are then differentiated from all other blood cells in the enriched sample, and... Agent: Townsend And Townsend And Crew, LLP

20100159507 - Shredder for mechanical disruption by gentle controlled compressive rotation: The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures.... Agent: Lando & Anastasi, LLP

20100159509 - Methods for increasing enzymatic hydrolysis of cellulosic material in the presence of a peroxidase: The present invention relates to methods for increasing hydrolysis of a cellulosic material, comprising: hydrolyzing the cellulosic material with an enzyme composition in the presence of a polypeptide having peroxidase activity.... Agent: Novozymes, Inc.

20100159508 - Thermally responsive micelles: The invention provides an amphiphilic copolymer comprising monomer units derived from a first monomer and monomer units derived from a second monomer. The copolymer has at least one hydrophobic endgroup. The first monomer is such that the copolymer is thermally responsive and the second monomer comprises a carboxylic acid or... Agent: Townsend And Townsend And Crew, LLP

20100159510 - Transgenic plants expressing civps or intein modified proteins and related method: Transgenic plants that express CIVPS or intein modified proteins, compositions of matter comprising them, products of diverse applications made from the transgenic plants, methods to construct the transgenic plants containing CIVPS or intein modified genes, methods to express CIVPS or intein modified proteins in plants, and methods of using the... Agent: Volpe And Koenig, P.C.

20100159512 - Method for the preparation of recombinant human thrombin and fibrinogen: The present invention discloses a novel method for the preparation of recombinant human proteins expressed in human cells. Specifically, the present invention relates to novel methods for the preparation of human recombinant thrombin and human recombinant fibrinogen. Moreover, the method employs serum-free culturing conditions and therefore provides recombinant human proteins... Agent: Thorpe North & Western, LLP.

20100159511 - Production of recombinant selenoprotein mutants with enhanced catalytic activity: The present invention generally relates to the production of industrially relevant quantities of selenoprotein enzymes in eukaryotic cell cultures. More specifically, the present invention generally relates to the production of such enzymes wherein one or more catalytic cysteine or serine residues are mutagenically replaced by selenocysteine.... Agent: Joseph J. Crimaldi Roetzel & Andress

20100159513 - Genes that increase peptide production: Several endogenous genes have been identified in Escherichia coli, the overexpression of which increases recombinant peptide production. Increasing the copy number of aroB, aroK, proB, or crl increases the amount of a recombinant peptide produced by a host cell. Recombinant host cells comprising at least one chimeric genetic construct encoding... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100159514 - System for production of ethanol and co-products with fractionation of feedstock and solvent washing of fermentation product: A system for the production of ethanol and co-products is provided. The system facilitates an overall reduction in the use of energy, for example, by reducing the mass of wet solids supplied to a distillation system. The system also reduces the amount of energy used to dry the wet solids... Agent: Fletcher Yoder P.C.

20100159516 - Organic solvent pretreatment of biomass to enhance enzymatic saccharification: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of one or more alkylamine and optionally one or more additional nucleophile to fragment and extract lignin. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100159517 - Organic solvent pretreatment of biomass to enhance enzymatic saccharification: Biomass is pretreated using an organic solvent solution, under alkaline conditions, in the presence of one or more organo-mercaptan and optionally one or more additional nucleophile to fragment and extract lignin. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100159518 - Organic solvent pretreatment of biomass to enhance enzymatic saccharification: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of one of more sulfide (hydrosulfide) salt and optionally one or more additional nucleophile to fragment and extract lignin. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100159519 - Organic solvent pretreatment of biomass to enhance enzymatic saccharification: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of elemental sulfur and optionally one or more alkylamine and/or one or more additional nucleophile to fragment and extract lignin. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100159520 - Organic solvent pretreatment of biomass to enhance enzymatic saccharification: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of ammonia and optionally an additional nucleophile to fragment and extract lignin without loss of hemicellulose. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for the... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100159522 - Organosolv and ozone treatment of biomass to enhance enzymatic saccharification: Lignocellulosic biomass comprising lignin is treated with a solvent, such as organosolv, under alkaline conditions at elevated temperatures, filtered, then contacted with a gas comprising ozone to produce a readily saccharifiable biomass.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100159515 - Oxidative pretreatment of biomass to enhance enzymatic saccharification: Lignocellulosic biomass comprising lignin is treated by selective extraction and oxidation of lignin using a solvent solution comprising water in combination with at least one Mn(III) salt to produce readily saccharifiable carbohydrate enriched biomass.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100159521 - Ozone treatment of biomass to enhance enzymatic saccharification: Methods for treating lignocellulosic biomass to produce readily saccharifiable carbohydrate-enriched biomass are provided. In one method, lignocellulosic biomass comprising lignin is treated with aqueous ammonia, then contacted with a gas comprising ozone at a temperature of about 0° C. to about 50° C. In another method, lignocellulosic biomass comprising lignin... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100159523 - Coryneform bacteria which produce chemical compounds i: The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20100159524 - Apparatus and methods for producing and using high-density cells and products therefrom: Disclosed and claimed is apparatus and methods for the growth of cells to high density, products therefrom and uses thereof. Also disclosed and claimed is the use of this method for the growth to high-density insect cells, such as the Spodoptera frugiperda Sf900+ cell line (ATCC: CRL 12579). Further disclosed... Agent: Frommer Lawrence & Haug

20100159525 - Extranuclear rna splicing in neuronal dendrites: The present invention relates to methods of synaptic network remodeling by means of extranuclear RNA splicing. The present invention also provides methods of extranuclear RNA splicing, and methods of protein translation based on extranuclear RNA splicing.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100159526 - Selective 5' ligation tagging of rna: The present invention provides novel compositions, kits and methods employing RNA 5′ polyphosphatases, RNA 5′ monophosphatases, capping enzymes, decapping enzymes, nucleic acid pyrophosphatases and RNA ligases, as well as other enzymes, for selective 5′ ligation tagging of desired classes of RNA molecules that differ with respect to particular chemical moieties... Agent: Casimir Jones, S.c.

20100159530 - Compositions and methods to detect candida albicans nucleic acid: Compositions are disclosed as nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes specific for Candida albicans 26S rRNA sequences or DNA encoding 26S rRNA. Methods are disclosed for detecting the presence of C. albicans in samples by using... Agent: Gen Probe Incorporated

20100159529 - Dry composition of reaction compounds with stabilized polmerase: The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (PCR) amplification after re-solubilization.... Agent: Roche Diagnostics Operations Inc.

20100159528 - Polymerase stabilization: The present invention relates to methods and compositions for providing purified thermostable enzymes, particularly thermostable DNA polymerases, that are free of exogenous detergents. The present invention also provides methods for providing such purified thermostable DNA polymerases to assays in an active form by adding one or more detergents. The present... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100159527 - Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification: Polypeptides having nucleic acid binding activity are provided. Methods of using polypeptides having nucleic acid binding activity are provided. Fusion proteins and methods of using fusion proteins are provided. Fusion proteins comprising a polymerase and a nucleic acid binding polypeptide are provided. Fusion proteins comprising a reverse transcriptase and a... Agent: Life Technologies Corporation C/o Intellevate

20100159532 - Method and device for performing a nucleic acid preparation and/or amplification: For the implementation of the method, a flexible tube is provided, which is always sealed below and hence at one end during the implementation of the sample preparation and/or amplification. In this tube, a biological sample is prepared and/or amplified. The use of only one tube is very economical. The... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100159531 - Methods and solutions for inhibiting undesired cleaving of labels: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that... Agent: Peter G. Carroll Medlen & Carroll, LLP

20100159533 - Simplified sample preparation for rna analysis: Methods and kits for selective preparing cDNA relatively free of sequences found in rRNA and subcellular RNAs are disclosed. The methods and kits utilize approximately 200 hexamer sequences which target messenger RNA. The methods and kits are useful in preparing samples for sequencing analysis, especially when performing single molecule sequencing... Agent: Lando & Anastasi, LLP

20100159534 - recombinant type ii restriction endonuclease, nmeaiii, and a process for producing the same: A protein is described that has an amino acid sequence characterized by at least 90% sequence identity with SEQ ID NO: 24, the protein being capable of recognizing a sequence consisting of 5′-GCCGAG-3′ within the double-stranded DNA and cleaving the substrate predominantly at 21/19 nucleotides from the recognition site. A... Agent: Harriet M. Strimpel, D. Phil.

20100159535 - Methods for increasing hydrolysis of cellulosic material: The present invention relates to methods for pretreating a cellulosic material, methods for degrading or converting a cellulosic material, methods for producing a fermentation product, and methods of fermenting a cellulosic material under anaerobic conditions.... Agent: Novozymes, Inc.

20100159536 - Methods for increasing hydrolysis of cellulosic material in the presence of cellobiose dehydrogenase: The present invention relates to methods for degrading or converting a cellulosic material, methods for producing a fermentation product, and methods of fermenting a cellulosic material with an enzyme composition comprising one or more (several) cellulolytic enzymes, a cellobiose dehydrogenase, and a polypeptide having cellulolytic enhancing activity.... Agent: Novozymes, Inc.

20100159537 - Escherichia coli strains that over-produce l-threonine and processes for their production: The invention relates to novel bacterial strains and constructs as well as methods for production of L-amino acids, including but not limited to L-threonine. Such novel bacterial strains may be characterized by, for instance, Escherichia coli strains in which an aspartate semialdehyde dehydrogenase (asd) gene is operably associated with at... Agent: Buchanan Ingersoll & Rooney PC (archer Daniels Midland Company)

20100159538 - Method for the chemoenzymatic production of fatty acid esters: A chemoenzymatic process for the production of fatty acid esters comprising partially esterifying one or more fatty acid esters, under mild temperatures with an enzymatic catalyst, and optionally in the presence of one or more inert solvents, with a 1- to 5-fold molar excess of one or more water-containing aliphatic... Agent: Fox Rothschild LLP

20100159539 - Methods and systems for producing biofuels and bioenergy products from xenobiotic compounds: The present invention provides methods and systems for producing biofuel and bioenergy products using, as starting raw material, xenobiotic materials or compounds. The xenobiotic materials or compounds may originate from industrial or chemical plants, municipal waste, pharmaceutical products, cosmetic and personal care products, or other sources, and may include aliphatic... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100159540 - Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof: Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ω-3 fatty acid metabolites, and derivatives... Agent: Klauber & Jackson

20100159541 - Gene associated with foam formation of acetic acid bacterium, acetic acid bacterium bred by modifying the gene and method for producing vinegar using the acetic acid bacterium: The object of the present invention is to provide a method for suppressing foam formation by identifying a gene involved in foam formation during culture of an acetic acid bacterium and reducing or deleting the function of a protein encoded by the gene, a method for more efficiently producing vinegar... Agent: Cadwalader, Wickersham & Taft LLP

20100159542 - Bacterial cells exhibiting formate dehydrogenase activity for the manufacture of succinic acid: The present invention relates to a bacterial cell of the genus Pastorella comprising a heterologous polypeptide having formate dehydrogenase activity. Moreover, the present invention also relates to a method of manufacturing succinic acid and the use of the bacterial cell for the manufacture of succinic acid.... Agent: Connolly Bove Lodge & Hutz, LLP

20100159543 - Bacterial cells having a glyoxylate shunt for the manufacture of succinic acid: The present invention is concerned with bacteria for the production of succinic acid. Specifically, the invention relates to a bacterial cell of the genus Pasteurella comprising a heterologous polypeptide having isocitrate lyase activity and a heterologous polypeptide having malate synthase activity. Further, the present invention contemplates a polynucleotide comprising a... Agent: Connolly Bove Lodge & Hutz, LLP

20100159544 - Homo-succinic acid producing microorganism variant and process for preparing succinic acid using the same: The present invention relates to microbial variants producing homo-succinic acid at high yields and a method for producing homo-succinic acid using the same, more particularly, to a microbial variant constructed by disrupting a lactate dehydro-genase-encoding gene (idhA) and an acetate kinase-encoding gene (ackA), as well as a method for producing... Agent: Edwards Angell Palmer & Dodge LLP

20100159545 - Method for production of corosolic acid in suspension culture of plant cells: The present invention relates to a method of producing corosolic acid by using plant cells that produce corosolic acid. More particularly, the present invention relates to a method of producing corosolic acid by using plant cell suspension cultures comprising the steps of: inducing a callus from a tissue of a... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20100159546 - Metabolic engineering of yeasts for the production of 1-butanol: The present invention provides genetically modified yeast cells, and methods of using those yeast cells, to produce 1-butanol. The yeast cell can be selected from the genera Saccharomyces, Candida, Pichia, Kluyveromyces, Issatchenkia, Yarrowia, Rhodotorula, Hansenula, Schizochytrium, or Thraustochytrium. The yeast cell of the invention overexpresses at least one enzyme that... Agent: Gary C. Cohn, PLLC

20100159547 - Method for separating oil from an oil containing material, method for the production of ethanol, and ethanol production facility: A method for separating oil from flour includes steps of: separating flour into a first stream comprising coarse flour and a second stream comprising fine flour; combining a first extraction solvent with the first stream and extracting oil from the first stream to provide a first miscella and coarse solids;... Agent: Merchant & Gould PC

20100159550 - System for production of ethanol and co-products with apparatus for solvent washing of fermentation product: A system for the production of ethanol and co-products is provided. The system facilitates an overall reduction in the use of energy, for example, by reducing the mass of wet solids supplied to a distillation system. The system also reduces the amount of energy used to dry the wet solids... Agent: Fletcher Yoder P.C.

20100159551 - System for production of ethanol and co-products with raw starch hydrolysis and solvent washing of fermentation product: A system for the production of ethanol and co-products is provided. The system facilitates an overall reduction in the use of energy, for example, by reducing the mass of wet solids supplied to a distillation system. The system also reduces the amount of energy used to dry the wet solids... Agent: Fletcher Yoder P.C.

20100159549 - System for production of ethanol and co-products with separation and solvent washing of fermentation product: A system for the production of ethanol and co-products is provided. The system facilitates an overall reduction in the use of energy, for example, by reducing the mass of wet solids supplied to a distillation system. The system also reduces the amount of energy used to dry the wet solids... Agent: Fletcher Yoder P.C.

20100159548 - System for production of ethanol and co-products with solvent washing of fermentation product: A system for the production of ethanol and co-products is provided. The system facilitates an overall reduction in the use of energy, for example, by reducing the mass of wet solids supplied to a distillation system. The system also reduces the amount of energy used to dry the wet solids... Agent: Fletcher Yoder P.C.

20100159552 - Process for alcoholic fermentation of lignocellulosic biomass: A process for the production of ethanol wherein a hydrolyzed lignocellulosic biomass is fermented in the presence of a stillage residue. The fermentation of cellulosic hydrolysates is improved by adding prior to and/or during fermentation a stillage residue side stream from a corn starch-to-ethanol process as a nutrient source for... Agent: Borden Ladner Gervais LLP Anne Kinsman

20100159554 - Biofuels processes integrating photobioreactors with anaerobic digestion: In the present invention, integrated processes for producing a biofuel are disclosed. Specifically, processes integrating photobioreactors with anaerobic digestion are disclosed. Anaerobic digestion can convert biomass into a biofuel. However, anaerobic digestion also produces carbon dioxide (CO2). Because it is a greenhouse gas, the production of carbon dioxide is not... Agent: Chevron U.s.a. Inc. Law - Intellectual Property Group

20100159553 - Production of gasoline from fermentable feedstocks: Compositions and methods for forming hexane, and, optionally, gasoline and/or components of a gasoline composition, from fermentable sugars are disclosed. The sugars are fermented using a bacteria or yeast that predominantly forms butyric acid. The butyric acid is subjected to Kolbe or photo-Kolbe electrolysis to form hexane. The hexane can... Agent: Guerry Leonard Grune

20100159555 - Production of secondary metabolites using capillary membranes: The invention provides methods of producing secondary metabolites and under recombinant products oxygen-limited or anaerobic culture conditions. The methods include providing a porous substrate having a first side and a second side and which has a biofilm of microorganisms attached to the first side thereof, and causing a nutrient solution... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100159556 - Method for manipulating magnetic particles in a liquid medium: A method of mixing magnetic particles (3) in a reaction chamber (2) that is part of a microfluidic device and that contains the said particles in suspension, comprises the steps: (a) providing an electromagnetic means (1,1′,6,7) to generate magnetic field sequences having polarity and intensity that vary in time and... Agent: Kevin J. Mcneely, Esq.

20100159557 - Pelletization process to control filamentous fungi morphology for enhanced reactor rheology bioproduct formation: Filamentous fungi are grown in pellet form by culturing the filamentous fungi in liquid culture under one or more of the following conditions: 1) with addition of particulate substrates: 2) using spores which have been stored for a period of time prior to inoculation; and 3) using high spore inoculum... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20100159558 - Reducing byproduction of malonates in a fermentation process: Described are methods of reducing the amount of byproduct organic acids during fermentation of an organism, based on expression of a heterologous malonyl-CoA synthetase. A polyunsaturated fatty acid [“PUFA”]-producing strain of the oleaginous yeast Yarrowia lipolytica was engineered to express a heterologous malonyl-CoA synthetase gene. The expression did not effect... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100159559 - Global amplification using random priming by a composite primer: The invention relates to the field of polynucleotide amplification. More particularly, the invention provides methods, compositions and kits for amplification of (i.e., making multiple copies of) a multiplicity of different polynucleotide template sequences using a randomly primed RNA/DNA composite primer.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100159560 - Method of producing microbial transglutaminase: The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral metalloprotease. An active microbial transglutaminase having the pro-structure part cleaved can be obtained by culturing a microorganism into which a gene encoding the neutral metalloprotease... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100159561 - Kits for amplifying dna: Kits for amplifying DNA which include a priming oligonucleotide that hybridizes to a 3′-end of a DNA target sequence, a displacer oligonucleotide that hybridizes to a target nucleic acid containing the DNA target sequence at a position upstream from the priming oligonucleotide, and a promoter oligonucleotide that includes a region... Agent: Gen Probe Incorporated

20100159562 - Fungus-induced inflammation and eosinophil degranulation: This document relates to methods and materials involved in fungus-induced inflammation and eosinophil degranulation. For example, isolated nucleic acids encoding fungal polypeptides, fungal polypeptides, methods for assessing fungus-induced inflammation, methods for assessing eosinophil degranulation, and methods for identifying inhibitors of fungus-induced inflammation and/or eosinophil degranulation are provided.... Agent: Fish & Richardson P.C.

20100159563 - Preparation and use of biofilm-degrading, multiple-specificity, hydrolytic enzyme mixtures: The present invention relates to isolated structures containing degradative enzymes produced from a marine organism. The enzymes produced are based on the carbon source upon which the marine organism is growing. The enzymes are found in structures that can be isolated such that the degradative enzymes are easily harvested.... Agent: Arent Fox LLP

20100159564 - Protease resistant recombinant bacterial collagenases: The identification of the most sensitive sites of Clostridium histolyticum collagenase Class 1 to proteolysis by proteases present during the fermentation and purification of the enzyme is described. Culture supernatant obtained after fermentation of C. histolyticum is used as the starting material for further purification of the enzyme. Native collagenase... Agent: Sanford J. Piltch, Esq.

20100159565 - Toxin-eating bacteria and bioremediation: Bacteria that can use antibiotics as a carbon source are provided. Methods and bacteria useful for bioremediation are also provided.... Agent: Banner & Witcoff, Ltd.

20100159566 - Systems and methods for producing biofuels and related materials: Clostridium phytofermentans cells (American Type Culture Collection 700394T) and all other strains of the species can ferment materials such as biomass into useful products and coproducts, such as ethanol, hydrogen and organic acids. Compositions that include Clostridium phytofermentans are also disclosed.... Agent: Milstein Zhang & Wu LLC

20100159567 - Preservation and composition of bioprocess algae for production of lipids, seedstock, and feed: The present invention relates to compositions and uses of a novel Dunaliella salina HT04 microorganism. In addition, the present invention relates to novel methods for culturing harvesting, preservation, production of algae seedstock and uses thereof.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100159568 - Gordonia sihwensis strain and uses thereof: Described herein is a strain of Gordonia sihwensis. The Gordonia sihwensis strain described herein may be used to sequester and/or biodegrade hydrocarbons. In particular, the Gordonia sihwensis strain described herein may be used in the remediation of drill cuttings coated with drilling fluid.... Agent: Jones Day

20100159569 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent: Xyleco, Inc. Celia Leber

20100159570 - Analyte determination methods and devices: The present invention provides methods and apparatuses for analyte detection.... Agent: Abbott Diabetes Care Inc. Bozicevic, Field & Francis LLP

20100159571 - Biogas plant for methanizing biomass having a high solids fraction: A biogas plant for methanizing biomass having a high solids fraction includes a digestion tank system having a plurality of digestion tanks adapted to be closed in a gas- and liquid-tight manner, each of which includes a charging and withdrawing opening for charging with biomass and withdrawing the biomass, a... Agent: Morrison & Foerster, LLP

20100159572 - Device and associated method: A microfluidic device for detecting one or more molecules of interest comprising: a non-conductive substrate; wherein the non-conductive substrate is provided with a plurality of thermally active elements is provided. A method for selectively functionalizing a plurality of thermally active elements is also provided.... Agent: General Electric Company Global Research

20100159574 - Microfluidic device and microfluidic analysis equipment: Provided are a microfluidic device and a microfluidic analysis equipment. The microfluidic device includes guides disposed along both edges, a lower plate including a flow path defined between the guides, and a movable upper plate moved along the guides on the lower plate and having a length less than that... Agent: Ampacc Law Group

20100159573 - Microfluidic dilution device: Provided is a microfluidic dilution device that uses capillary force to dilute first and second fluids in a predetermined ratio. The microfluidic dilution device includes a channel plate, a cover plate, fluid chambers, and a confluence chamber. The fluid chambers are filled with first and second fluids in a predetermined... Agent: Ampacc Law Group

20100159575 - Quantitative sampler of pathogens in exhaled air: A quantitative sampler of pathogens in exhaled air is provided. The quantitative sampler includes an air inputting pipe for a sampled individual to blow exhaled air; a check valve unit for preventing the exhaled air from reversely flowing; an aerosol filtering unit having an aerosol filtering material for collecting aerosol... Agent: Kirton And Mcconkie

20100159576 - Biochip and biomaterial detection apparatus: Provided are a biochip and a biomaterial detection apparatus. The biochip includes a substrate, a metal layer, and a dielectric layer. The substrate includes a surface having a plurality of acute parts which are formed by first and second inclined planes. The metal layer is formed on at least one... Agent: Ampacc Law Group

20100159577 - Automatic culture device, slide valve, and disposable container: A culture device includes: a housing accommodating therein a preservation container preserving a first solution liquid for cell culture, the housing having an opening for discharging the first solution liquid out of the housing; a cultivation container having an opening, in which the cell culture can be performed; and a... Agent: Mots Law PLLC

20100159578 - Method and system for robotic algae harvest: A Robotic Algae Harvester (RAH) of the present invention works by providing a CO2 collection mechanism that is installed in power plants or vehicles. These systems are available using current technology and have been proven to be scalable. CO2 is then transported to RAH using ships. The RAH will feed... Agent: White-welker & Welker, LLC

20100159579 - Photobioreactor systems: The invention provides for photobioreactor systems that can be used for the growth of photoautotrophic organisms. The photobioreactor systems can be scalable and modular, such that the production capacity of a photobioreactor system can be readily increased or decreased. The system may include photobioreactor units or blades that can be... Agent: Wilson, Sonsini, Goodrich & Rosati

20100159581 - Adsorbent filter media for removal of biological contaminants in process liquids: Adsorbent filter media particularly suited for removal of biological contaminants in process liquids. A porous fixed bed of adsorbent material is formed, using only a granular adsorbent and a water-insoluble thermoplastic binder. The resulting composite filter allows for a higher amount of adsorbent with smaller adsorbent particles than conventional depth... Agent: Nields, Lemack & Frame, LLC

20100159580 - Cell culture compartment unit and array including the same: Provided are a cell culture compartment unit and an array including the same. The cell culture compartment unit includes: a cell culture region and a bio material emission region including a cell culture fluid, which are separated with a porous membrane therebetween; a piezoelectric device on the porous membrane of... Agent: Ampacc Law Group

20100159582 - Disposable multiplex polymerase chain reaction (pcr) chip and device: A polymerase chain reaction (PCR) device including a chip assembly, a plurality of chambers being provided in said chip assembly adapted to hold samples, heating means wherein said chip assembly being located on said heating means whereby said chip assembly is allowed to operatively rotate on said heating means, a... Agent: Workman Nydegger 1000 Eagle Gate Tower

20100159583 - Apparatus for producing feeds comprising dried and fermented animal and plant residues and dried and fermented fertilizers: In organic waste treatment, initial investment and running costs are suppressed, and inexpensive and good-quality dried and fermented feeds and fertilizers are manufactured from animal and plant residues. The animal and plant residues having been reserved/accumulated in a fermentation tank and generated fermentation heat is emitted/sprayed with air into a... Agent: Abelman, Frayne & Schwab

20100159584 - Method and apparatus for obtaining aliquot from liquid-based cytological sample: Sample vials and methods of processing the sample vials are provided. The sample vial comprises a vial container, a sample collection chamber within the vial container, a vial cap configured to be mated with the vial container to enclose the collection chamber, an aliquot chamber, which may be carried by... Agent: VistaIPLaw Group LLP

20100159585 - Suppressor trna transcription in vertebrate cells: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20100159587 - Antibodies against human angiopoietin 2: The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100159586 - Hybrid suppressor trna for vertebrate cells: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20100159588 - Conditioned media and methods of making a conditioned media: A stable and scalable process is provided to manufacture reduced serum umbilical cord tissue-derived (UTC)-conditioned media. The method includes the culture of a UTC under reduced serum conditions. Subsequently, the UTC is washed and grown in serum-free basal media. After approximately 24 hours, the conditioned media is collected, filtered and... Agent: Patton Boggs LLP

20100159589 - Nestin-expressing hair follicle stem cells: Hair follicle stem cells are isolated by virtue of understanding their location within the hair follicle during telogen phase.... Agent: Morrison & Foerster LLP

20100159590 - Systems and methods for active microfluidic cell handling: A method and system for providing a cell support system are described. The method and system include providing a first block, a second block coupled to the first block, and a plurality of microfluidic channels. The first block includes a plurality of cell wells therein. The second block includes a... Agent: Convergent Law Group LLP

20100159592 - Emulsion compositions: An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality of compartments containing a functional in vitro eukaryotic expression... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20100159591 - Methods and compositions concerning sirna's as mediators of rna interference: The present invention concerns an isolated siRNA of from about 5 to about 20 nucleotides that mediates RNA interference. Also disclosed are methods of reducing expression of a target gene in a cell comprising obtaining at least one siRNA of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14,... Agent: Life Technologies Corporation C/o Intellevate

20100159594 - Single chain trimers and uses therefor: Single chain trimer (SCT) molecules are disclosed, comprising an MHC antigen peptide sequence, a β2-microglobulin sequence and a full-length MHC class I heavy chain sequence, joined by linker sequences. Further described are nucleic acids encoding single chain trimers. Methods for expansion of antigen-specific T cell populations using single chain trimer... Agent: Washington University-snr C/o Sonnenschein Nath & Rosenthal L.l.p

20100159593 - Transfection reagents: Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester,... Agent: Life Technologies Corporation C/o Intellevate

20100159595 - Method of generating myelinating oligodendrocytes: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFRα+.... Agent: Quarles & Brady LLP

20100159596 - Small molecule compounds for stem cell differentiation: R1 is independently hydrogen or (C1-C6)alkyl; R2 is independently hydrogen, (C1-C6)alkyl, aryl, or heteroaryl; R2′ is independently hydrogen, (C1-C6)alkyl, CF3 or C2F5; R3 is independently (C1-C6)alkyl, aryl, 2-tetrahydrofurylmethyl, an aliphatic tertiary amine, or 4-methoxybenzyl; or R2 and R3 may be joined together to form a 5 or 6 member ring... Agent: Dla Piper LLP (us)

20100159597 - Cell culture membrane, cell culture kit, porous material, production method for cell culture membrane and production method for porous material: To produce a cell culture membrane having biocompatibility utilizing DNA of natural resources and a cell culture kit, the cell culture membrane having DNA ionically-cross-linked with calcium ions or magnesium ions is provided. To produce a porous material utilizing DNA, a production method for a cell culture membrane and a... Agent: Burr & Brown

20100159598 - In vitro methods for the induction and maintenance of plant cell lines as single suspension cells with intact cell walls, and transformation thereof: The subject invention provides simple and consistent methods to break suspension cell aggregates to single cells with intact primary cell walls. The subject invention relates in part to cell separation of suspension cell aggregates cultured in medium containing pectin-degrading enzymes or tubulin de-polymerizing compounds including colchicine. The subject invention also... Agent: Baker & Daniels LLP- Dow Agrosciences

  
06/17/2010 > patent applications in patent subcategories. invention type

20100151435 - Compositions and methods for tissue preservation: Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100151436 - Methods for ex vivo administration of drugs to grafts using polymeric nanoparticles: Methods for ex vivo administration of drugs to grafts using polymeric micro- and nanoparticles and applications for these methods are described herein. The particles contain encapsulated molecules which are released locally at the site of implantation and function to prevent graft rejection or aid in the proper adaptation of the... Agent: Pabst Patent Group LLP

20100151437 - Method for isolating cellular products by cryopreservation: Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a tissue having desired cells that are less prone to destructive freezing and undesired cells that are more prone to destructive freezing, or pre-treating a tissue to... Agent: Oliff & Berridge, PLC

20100151438 - Methods and kits for enhancing sedimentation and recovery of cells in a sample: The methods and kits provide sedimentation-enhancing agents that significantly increase the efficiency of cell-sedimentation. They also increase the efficiency of blood cell separation methods and thereby increase the recovery of total nucleated cells.... Agent: General Electric Company Global Research

20100151439 - Enzymatic assays for a droplet actuator: A method of conducting a droplet-based enzymatic assay is provided. The method generally makes use of a droplet actuator. A droplet comprising an enzyme of interest is provided on the droplet actuator along with a droplet comprising a substrate which is potentially modified in the presence of the enzyme. The... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20100151440 - High throughput screening platform for high ethanol: Provided herein are high throughput methods for converting starch-containing plant material to ethanol, wherein the conversion process is performed at a small scale. This high-throughput screening platform permits the evaluation of the ethanol obtained from starch-containing plant material in a rapid and efficient manner. The methods include obtaining a plurality... Agent: Dana Rewoldt Garst Seed Company

20100151444 - Detection method for human pappilomavirus (hpv) and its application in cervical cancer: Embodiments of the invention provide methods, assays, and kits for detecting HPV infection and HPV associated epithelial cell abnormalities, most notably those associated with pre-malignant and malignant epithelial cell lesions. Detection of HPV DNAs, genomes, and/or oncoproteins by nucleic acid hybridization assays and immunological assays can be used in early... Agent: Shu-ling Cheng

20100151441 - Human cytomegalovirus latency promoting genes, related virus variants and methods of use: Latency promoting genomic sequences from human cytomegalovirus (HCMV) and virus variants lacking function of one or more of the latency promoting genes are disclosed. Also disclosed are methods of using the altered viruses and latency promoting genes and their gene products for the production of vaccines and for identifying antiviral... Agent: Marshall, Gerstein & Borun LLP

20100151446 - Method for counting and segmenting viral particles in an image: The method is for intracellular counting and segmentation of viral particles in an image. An image is provided that has a plurality of items therein. A radius range of viral particles is determined. Round items in the image having a radius within the predetermined radius range are identified. Elliptical items... Agent: Fasth Law Offices (rolf Fasth)

20100151442 - Method for detecting emerging pandemic influenza: A method for detecting emerging pandemic influenza strains is provided. RT-PCR is used to detect HPAI followed by pyrosequencing to detect codons defining human or avian influenza signatures. This method screens for avian influenza viruses containing mutations suspected of making the virus more infective or virulent to humans.... Agent: Husch Blackwell Sanders LLP

20100151447 - Method for double staining in immunohistochemistry: The present invention relates to kits and methods for performing dual-staining immunohistochemistry (IHC) for the detection of specific cell populations in tissue samples containing heterogeneous populations of cells, which can be observed by a light microscope for co-localization of distinct pigments. The method includes providing a tissue sample comprising fixed... Agent: Nixon Peabody LLP - Patent Group

20100151443 - Microfluid system and method to test for target molecules in a biological sample: A system and method to test for the presence of target molecules in a biological test sample includes test molecules, a microfluidic chip, and irradiating and detection devices. The test molecules include bio-recognition molecules conjugable with the target molecules, and the corresponding conjugates. The microfluidic chip includes sample channels and... Agent: Patent Group C/o Dla Piper US LLP

20100151445 - Multiplex method for detecting an infection: The invention relates to a method for the in vitro diagnostic detection of an infection with a microorganism, comprising placing a biological sample, in a single assay receptacle, in the presence of particles, each carrying at least one specific detectable physical parameter, and belonging to at least two different groups,... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100151448 - Asymmetric pcr amplification, its special primer and application: The present invention discloses an asymmetric PCR amplification method, its special primer and application, aims to provide a simple, effective PCR amplification for preparation of single-stranded product. The asymmetric PCR primer of the invention comprises some PCR primer pairs, in which an unrelated nucleic acids sequence to target sequence to... Agent: Morrison & Foerster LLP

20100151481 - Cell-signaling assays: Assays for detecting the presence and activity of cell-signaling components. These assays include luminescence polarization assays for detecting cell-signaling nucleotides and modulators of receptors and enzymes related to the generation and activity of such nucleotides.... Agent: Kolisch Hartwell, P.C.

20100151475 - Chemical reaction cartridge, its fabrication method, and a chemical reaction cartridge drive system: This cartridge is intended to be used for performing chemical reaction of samples, comprising a container formed of a rigid substrate and an elastic body, wherein two or more chambers linked or arranged to be able to be linked through flow paths are formed in said container, and wherein said... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100151450 - Classification method: The invention provides a method of classifying a microorganism present in a sample comprising the steps of (a) digesting nucleic acid derived from the microorganism with at least one restriction enzyme; and (b) determining the melting profile of the restriction fragments produced in step (a). The melting profiles may he... Agent: Schwegman, Lundberg & Woessner, P.A.

20100151464 - Compositions and methods for preparing oligonucleotide solutions: The present invention is directed to methods and compositions for generating a pool of oligonucleotides. The invention finds use in preparing a population or subpopulations of oligonucleotides in solution. The pool of oligonucleotides finds use in a variety of nucleic acid detection and/or amplification assays.... Agent: Mcdermott, Will & Emery

20100151472 - Detection composition: The invention provides methods, kits, devices and compositions for detecting one or more target analytes. In some embodiments, the invention provides binding elements and labeling elements capable of being joined through a plurality of joining elements.... Agent: Wilson, Sonsini, Goodrich & Rosati / Nodality, Inc

20100151457 - Detection of unhealthy cell and uses thereof: Provided herein is a method for detecting the presence of unhealthy cell in a subject using the expression of PDPK FA/GSK-3α in cell and uses thereof. In another aspect, provided herein is a method for predicting if a subject is systemically unhealthy and at risk of developing systemic diseases and... Agent: Hogan & Hartson L.L.P.

20100151466 - Diagnosis and treatment of cervical cancer: In certain aspects, the invention relates to methods of diagnosing cervical cancer by using a combination of certain biomarkers such as hTERT, IGFBP-3, transferrin receptor, beta-catenin, Myc-HPV E6 interaction, HPV E7, and telomere length. In other aspects, the invention relates to methods of detecting immortalization of cervical cells by using... Agent: Wolf Greenfield & Sacks, P.C.

20100151453 - Dot1 histone methyltransferases as a target for identifying therapeutic agents for leukemia: The present invention provides polypeptides with histone H3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest. Further provided are diagnostic methods for leukemia and... Agent: Myers Bigel Sibley & Sajovec

20100151468 - Epigenetic biomarkers for early detection, therapeutic effectiveness, and relapse monitoring of cancer: The present invention provides methods of detection, including early detection, for cancer or other diseases and normal physiologic processes mediated by global epigenetic changes, by using one or more of the following biomarkers: a global DNA methylation index, a global histone H4 acetylation index, and a global histone H4 trimethylation... Agent: Pearl Cohen Zedek Latzer, LLP

20100151480 - Exosome-associated microrna as a diagnostic marker: The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more RNAs present in cancer-derived exosomes isolated from a biological sample from the subject.... Agent: Stites & Harbison, PLLC

20100151461 - Genetic markers for schizophrenia and bipolar disorder: The invention provides haplotypes and SNPs of the HPCAL1 and SV2C genes which predict the risk for developing schizophrenia or bipolar disorder and predict which patients are likely to respond to a given treatment or are more likely to experience negative side effects.... Agent: Fish & Richardson PC

20100151462 - Human diabetes susceptibility shank2 gene: The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the SHANK2 gene locus in a biological sample of said subject.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100151459 - Marker for detecting the proposed efficacy of treatment: e

20100151463 - Method for determining the likelihood of response to her2 inhibitors: The present disclosure provides methods for determining the HER2 Status of a cancer tumor sample.... Agent: Genomic Health, Inc. C/o Kathleen Determann

20100151451 - Method for identifying the genotype in position 171 of the ovine prion protein as well as kits for implementing said method: e

20100151449 - Method for poduction of l-amino acids by fermentation: The invention relates to a method for production of L-amino acids by fermentation. According to the invention, the activity of the alanine transaminase is ether reduced or inhibited, whereby in particular the amino acids L-valine, L-lysine and L-isoleucine are produced with increased yield. Furthermore, the nucleic acids according to seq.... Agent: Kf Ross PC

20100151456 - Method for the assay of liver fatty acid binding protein, ace and ca 19-9 for the in vitro diagnosis of colorectal cancer: A method for the in vitro diagnosis of colorectal cancer by determining the presence of Liver Fatty Acid-Binding Protein, ACE and CA19-9 tumor markers in a biological sample taken from a patient suspected of having colorectal cancer. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis,... Agent: Oliff & Berridge, PLC

20100151467 - Methods and compositions for diagnosing and monitoring transplant rejection: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also... Agent: Morrison & Foerster LLP

20100151473 - Methods and compositions for hybridizing nucleic acids: Methods and compositions for hybridizing nucleic acids are disclosed herein. Also disclosed herein are methods and compositions to detect a nucleic acid provided to an array.... Agent: Knobbe Martens Olson & Bear LLP

20100151470 - Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy: The present invention provides methods for the rapid and cost effective identification of the presence of a disease-associated mutation and a particular SNP in the same allele of a gene without the need to clone and sequence the entire gene. The compositions and methods of the invention are useful for... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100151452 - Methods and systems for searching for regulators of the fer protein and for monitoring the effects of the fer protein: A method for modulating a Fer mediated pathway in a cell, for monitoring the effect of a Fer protein in a cell, for altering and inhibiting one or more effects of a Fer protein in a cell is provided. The method includes modulating, monitoring, altering or inhibiting any one or... Agent: The Nath Law Group

20100151478 - Methods for disease detection: The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.... Agent: Patent Department Choate, Hall & Stewart LLP

20100151471 - Methods of monitoring conditions by sequence analysis: There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer. Provided herein are methods for using DNA sequencing to identify personalized biomarkers in patients with autoimmune disease and other conditions. Identified biomarkers can be used to determine the... Agent: Wilson, Sonsini, Goodrich & Rosati

20100151454 - Microfluidic apparatus, systems, and methods for performing molecular reactions: Disclosed herein are methods, apparatuses, and systems for performing nucleic acid sequencing reactions and molecular binding reactions in a microfluidic channel. The methods, apparatuses, and systems can include a restriction barrier to restrict movement of a particle to which a nucleic acid is attached. Furthermore, the methods, apparatuses, and systems... Agent: Pillsbury Winthrop Shaw Pittman LLP (intel)

20100151474 - Multifunctional device for diagnostics and method for testing biological objects: A multifunctional device for measuring fluorescence, luminescence and light transmission for diagnostics. A sample carrier is designed in the form of a biochip, cell, pan or microplate. The device comprises a first and second group of screens mounted behind the rear surface of a sample solid carrier. Light sources of... Agent: John Alumit

20100151458 - Oligoribonucleotides and ribonucleases for cleaving rna: Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2′-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementary nucleic acid strand as well as substituent groups for increasing nuclease resistance. The oligomeric compounds are useful for diagnostics... Agent: Woodcock Washburn LLP

20100151476 - Phenylthiocarbamide (ptc) taste receptor: The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC... Agent: Klarquist Sparkman, LLP

20100151477 - Reducing non-target nucleic acid dependent amplifications: amplifying repetitive nucleic acid sequences: The present invention provides for compositions and methods for amplifying target nucleic acids using nucleic acid primers designed to limit non-target nucleic acid dependent priming events. The present invention permits amplifying and quantitating the number of repetitive units in a repetitive region, such as the number of telomere repetitive units.... Agent: Ballard Spahr LLP

20100151469 - Sample-processing reagent compositions, methods, and devices: Stable compositions comprising a nucleic acid binding support material comprising a substrate with functional groups attached to the substrate; a lysing enzyme; a water dispersible matrix material; and a saccharide, methods of using the compositions, and products and devices which include the compositions are disclosed.... Agent: 3m Innovative Properties Company

20100151465 - Selective capture and release of analytes: The described subject matter includes techniques and components for minimally invasive, selective capture and release of analytes. An aptamer is selected for its binding affinity with a particular analyte(s). The aptamer is functionalized on a solid phase, for example, microbeads, polymer monolith, microfabricated solid phase, etc. The analyte is allowed... Agent: Baker Botts L.L.P.

20100151479 - Sensing apparatus and method: A sensing apparatus comprising an ion sensitive field effect transistor arranged to generate an electrical output signal in response to localised fluctuations of ionic charge at or adjacent the surface of the transistor, and means for detecting the electrical output signal from the ion sensitive field effect transistor, the localised... Agent: Nixon & Vanderhye, PC

20100151460 - Systems and methods for biological and chemical detection, comprising automatic selection of reagent sets: The instant invention relates to systems of reagents and methods for the detection of chemical and biological targets in a sample. Some embodiments comprise methods for automatically selecting a set of reagents to detect one or more targets in a sample, wherein the set of reagents comprises at least two... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100151455 - Use of base-modified deoxynucleoside triphosphates to improve nucleic acid detection: Aspects of the invention provide novel and surprisingly effective methods for the detection of nucleic acids, comprising nucleic acid amplification using base-modified deoxynucleoside 5′-triphosphates (dNTPs). Particular aspects relate to methods for enhancing hybridization properties of oligonucleotide primers and probes in assays detecting nucleic acids, comprise amplifying target DNAs in presence... Agent: Davis Wright Tremaine, LLP/seattle

20100151490 - Antigenic protein conjugates and process for preparing same: An improved process for the preparation of antigenic protein conjugates is provided. The conjugates preferably are formed through reaction with one or more free sulfhydryl groups in the antigenic protein. The process of the present invention preferably employs a trialkylphosphine as the reducing agent and allows for reduction of disulfide... Agent: Paul D. Yasger Abbott Laboratories

20100151482 - Diagnosis of fasciolosis by skin test (intradermoreaction) using the antigen fh8 (fasciolin): Fasciolosis is an anthropozoonotic disease caused by the Trematoda Fasciola hepatica. This worm is a common parasite of ruminants namely sheep, goats and cattle. Adult worms are usually found in the bile ducts of the final host liver, causing significant economic losses in the animal husbandry industry. The diagnosis of... Agent: Cermak Kenealy Vaidya & Nakajima LLP

20100151487 - Hepcidins as biomarkers for impending lupus nephritis flare: Biomarkers for determining a kidney flare episode in systemic lupus erythematosus are described.... Agent: Macmillan Sobanski & Todd, LLC

20100151484 - Kinase and ubiquination assays: Compositions, including antibodies, polypeptides, and organic molecules, kits, and methods for probing molecular interactions (e.g., deubiquination, ubiquination and kinase activity), e.g., using resonance energy transfer (RET) are provided.... Agent: Life Technologies Corporation C/o Intellevate

20100151489 - Method for quantifying biomolecules conjugated to a nanoparticle: Disclosed embodiments concern quantifying a biomolecule conjugated to a nanoparticle. Quantifying typically comprises determining the number of biomolecules per nanoparticle. Any suitable biomolecule can be used, including but not limited to, amino acids, peptides, proteins, haptens, nucleic acids, oligonucleotides, DNA, RNA, and combinations thereof. A single type of biomolecule may... Agent: Klarquist Sparkman, LLP

20100151486 - Osteopontin functional epitopes, monoclonal antibodies against the epitopes and uses thereof: Provided are functional epitopes of osteopontin (OPN), monoclonal antibodies that specifically bind to the epitopes, immunoconjugates comprising the monoclonal antibodies and use of the monoclonal antibodies or immunoconjugates for manufacturing a medicament for the treatment of tumor. Also provided are nucleotide sequences encoding the monoclonal antibodies and vectors and host... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100151488 - Rapid test for glycated albumin: A rapid immunochromatographic assay system is provided for measuring the amount of glycated albumin in a blood sample relative to the total level of albumin in the sample. The assay system is comprised of a disposable cassette that contains the test strips and testing reagents, and a measurement device that... Agent: K&l Gates LLP

20100151485 - Reagent for detection of analyte and process thereof: The present disclosure provides a reagent for detection of analyte in a sample and process of preparation of the reagent. The reagent comprises heparin and substrate coated with the analyte-counterpart. The analyte-counterpart of the reagent is capable of binding to said analyte. The present disclosure further provides a process for... Agent: Townsend And Townsend And Crew, LLP

20100151483 - Reagents for the detection of protein phosphorylation in signaling pathways: The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100151491 - Chemical surface nanopatterns to increase activity of surface-immobilized biomolecules: The present invention has been achieved in order to solve the problems which may occur in the nanopatterning of biomolecules with an aim to improve the activity and bio-recognition properties of the surface-immobilized biomolecules. A structure for bio-detection according to one aspect of the present invention comprises a large-scale chemical... Agent: Sughrue Mion, PLLC

20100151492 - Methods for the treatment of infections and tumors: PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus,... Agent: Klarquist Sparkman, LLP

20100151493 - Multicolor flow cytometry compositions containing unconjugated phycobiliproteins: Novel compositions containing (i) ligand conjugated phycobiliprotein tandem dyes and (ii) unconjugated phycobiliproteins are provided wherein the phycobiliproteins are derived from the same bacterial or eukaryotic algae species. The phycobiliproteins must be the same or different, but must contain some non-crosslinked subunits which exchange. Also provided are methods for preparing... Agent: Howson & Howson LLP / Beckman Coulter, Inc.

20100151496 - Assays for nuclear hormone receptor binding: Methods and genetic constructs are provided for detecting the binding of nuclear hormone receptors to a coactivator/corepressor. The methods employ enzyme fragment complementation using fragments of β-galactosidase as the detection system. Cells are transformed to express the large fragment of β-galactosidase fused to a member of the complex with NHR... Agent: Peters Verny , L.L.P.

20100151497 - Fluorescence-based assay for detecting compounds for modulating the sodium-calcium exchanger (ncx) in \"forward mode\": t

20100151498 - Method of diagnosing asthenozoospermia: After sampling semen from healthy males and from patients whose chief complaint was infertility, the semen volume, sperm concentration, sperm motility rate, and sperm survival rate in each of the specimens were measured, sperm-bound SPMI was detected using an anti-SPMI antibody, and the amount and rate of SPMI binding were... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100151499 - Proteolytic release of glycans: The present disclosure provides strategies for analyzing protein-linked glycans, and particularly for analyzing glycans on cell surface glycoproteins.... Agent: Choate, Hall & Stewart LLP

20100151500 - Compositions, devices, kits and methods for detecting hookworm: Methods, devices, kits and compositions for detecting the presence or absence of hookworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of hookworm in a fecal sample from a mammal that may... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100151501 - Forms of prostate specific antigens and methods for their detection: Inactive precursor forms of PSA (pPSA) have been identified to exist in serum and tissues of patients with prostate cancer. Antibodies specific for pPSA are provided. Methods for detecting inactive precursors of PSA in human physiological fluid and tissues are also provided, as well as diagnostic kits and methods useful... Agent: Sterne Kessler Goldstein & Fox, P.l.l.c.

20100151502 - Functional expression of triacylgylcerol lipases: The present invention relates to nucleic acids that code for triacylglycerol lipases, vectors comprising said nucleic acids, host cells comprising said nucleic acids or vectors, methods for the expression of triacylglycerol lipases in prokaryotes, methods for the detection and for the production of triacylglycerol lipases, triacylglycerol lipases obtainable thereby, and... Agent: Connolly Bove Lodge & Hutz, LLP

20100151494 - Fret protease assays for clostridial toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Allergan, Inc.

20100151495 - Reagents for the detection of protein phosphorylation in carcinoma signaling pathways: The invention discloses nearly 443 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100151504 - Diagnosis and risk classification of acute coronary syndrome by means of ct-proet-1 in combination with nt-probnp: The invention relates to a method for diagnosis and/or risk classification for acute coronary syndrome (ACS), in particular for acute myocardial infarct (AMI) and angina pectoris (AP) and/or a post-myocardial infarct, wherein a determination of the C-terminal pro-endothelin (CT-proET-1) or fragments and partial peptides therefrom, is carried out in combination... Agent: Connolly Bove Lodge & Hutz, LLP

20100151503 - Method of detecting liver cancer, diagnostic for liver cancer and remedy for cancer: Disclosed are a method for detecting liver cancer capable of detecting liver cancer with high specificity and a diagnostic therefor, as well as a novel therapeutic drug for cancer having an excellent anticancer effect. The method for detecting liver cancer cells in a sample utilizes as an index the expression... Agent: Birch Stewart Kolasch & Birch

20100151506 - Chloroacetamidine based inhibitors and activity based probes for the protein arginine methytransferases: In accordance with certain embodiments of the present disclosure, a protein arginine methyltransferase inhibitor is provided. The inhibitor comprises an amino acid peptide joined to a chloroacetamidine warhead.... Agent: Dority & Manning, P.A.

20100151505 - Methods for modulating thermostability and acid tolerance of microbes: The present invention relates a method for modulating thermostability or acid tolerance of a microbe, comprising the steps of: (a) conferring a substitution mutation to a homoserine o-succinyltransferase (MetA)-encoding nucleotide sequence; and (b) transforming the MetA-encoding nucleotide sequence into a microbial cell. The mutated MetA of the present invention shows... Agent: Edwards Angell Palmer & Dodge LLP

20100151507 - Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same: Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections... Agent: Woodcock Washburn LLP

20100151508 - Compounds: Flavonoid-type compounds of the Formula (II); in which R1 is alkyl C2 to C20, R2, R3, R4 and R5 are any one or more of hydrogen, alkyl, alkenyl, alkynyl, phenyl or benzyl, especially 7-decyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopy-ran-4-one or 7-ethyl-3-hydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one provide fluorescent probes and antioxidants, and are useful in discriminating healthy and stressed cells.... Agent: Taft, Stettinius & Hollister LLP

20100151509 - Reagent, kit and method for differentating and counting leukocytes: The present disclosure discloses a reagent for differentiating and counting leukocytes which includes: (1) cationic cyanine compounds selected from those having the following general formulae I and II; (2) cationic surfactants selected from those having the following general formulae III, IV and/or V; (3) at least one nonionic surfactant; and... Agent: Mindray C/o Stoel Rives LLP

20100151510 - Substrate for cell culture, producing method thereof and screening method for cell culture conditions utilizing the same: A cell culture substrate having at least one area for culturing a cell on a substrate, characterized in that the culturing area comprises an area releasably holding a biologically active substance having a biological activity to the cell and an area for immobilizing a biologically active substance having a biological... Agent: Fitzpatrick Cella Harper & Scinto

20100151511 - Biological culture assembly: The invention relates to a resealable or a single use cell culture assembly for use in growing, storing and transporting, cell and tissue cultures. The assembly includes a support frame for receiving a base member insert having an upper surface, such as a microscope slide, and a well frame, preferably... Agent: Millipore Corporation

20100151512 - Haemolysator: A haemolysator having a sonotrode plate and oscillation generating elements acting thereupon, wherein the oscillation generating elements are set into mechanical oscillations by an electrical AC-signal generator. The haemolysater also includes a sample chamber to which the sonotrode plate transmits mechanical oscillations, and has oscillation generating elements that are excitable... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100151513 - Device and method for tissue handling and embedding: A tissue embedder comprising a transport mechanism for an input member, the input member adapted to hold a plurality of tissue supports, with each tissue support associated with a mould, a wax bath and a cooling station wherein the transport mechanism moves the input member from a wax bath to... Agent: Sughrue Mion, PLLC

20100151515 - Microbial trypsin mutants having chymotrypsin activity and nucleic acids encoding same: The present invention relates to microbial trypsin variants having chymotrypsin-like activity, comprising: (a) a one or more substitutions corresponding to positions 144, S193A, 198, 201, 218, 223, 227, 228, 229, 230, and 231 of amino acids 25 to 248 of SEQ ID NO: 2, (b) one or more deletions corresponding... Agent: Novozymes, Inc.

20100151514 - Novel mucin-type glycoprotein and use thereof: Provided is a novel mucin-type glycoprotein and a method for producing the same. Specifically, a mucin-type glycoprotein having a repeat structure including 3 to 2000 repeating units each having an amino acid sequence represented by the formula I: Val-Xaa-Glu-Thr-Thr-Ala-Ala-Pro [wherein Xaa represents Val or Ile] (SEQ ID NO: 1), wherein... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100151516 - Gene sms 13: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, PC

20100151519 - Method for production of isoprenoids: The present invention is directed to variant squalene synthase enzymes, including Saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes. These variant enzymes produce squalene at a lower rate than the wild-type enzyme, allowing more farnesyl pyrophosphate to be utilized for production of isoprenoid compounds,... Agent: K&l Gates LLP

20100151521 - Method for stable gene-amplification in a bacterial host cell: A bacterial host cell is disclosed including at least two copies of an amplification unit in its genome, the amplification unit including: i) at least one copy of a gene of interest, and ii) an expressible conditionally essential gene, wherein the conditionally essential gene is either promoterless or transcribed from... Agent: Novozymes North America, Inc.

20100151517 - Methods for carrying out the selective evolution of proteins in vivo: The present invention relates to methods for producing variants of proteins which have improved properties in comparison with the initial protein, the variants being obtained with the aid of an in vivo evolution method.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100151520 - Translation enhancer elements of genes encoding human tau protein and human alpha-synuclein protein: The invention relates to translation enhancer elements that enhance translation of the gene encoding the human microtubule-associated tau protein and nucleic acid molecules that enhance translation of the gene encoding the human α-synuclein protein. The translation enhancer elements of the invention are useful in compositions and methods for identifying compounds... Agent: Wolf Greenfield & Sacks, P.C.

20100151518 - Vectors and methods for enzyme production: The invention provides a method for producing a replicase EF-Ts, EF-Tu and β polypeptide subunits, the method comprising expressing in a suitable host cell the EF-Ts and EF-Tu subunits, followed by expressing the β subunit, wherein the EF-Ts and EF-Tu subunits are operably linked to a first promoter and the... Agent: Howson & Howson LLP

20100151524 - Compositions and methods for increasing bone mineralization: A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate... Agent: Marshall, Gerstein & Borun LLP

20100151522 - Process for producing recombinant fibrinogen highly producing cell and highly producing cell: When genes encoding three kinds of proteins constituting fibrinogen, an α chain (or variant of α chain), a β chain and a γ chain (or variant of γ chain) are incorporated into an animal cell, a constitutional ratio of respective genes is such that a γ chain (and/or variant of... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100151523 - Regulated expression of recombinant proteins from adeno-associated viral vectors: Single AAV vector constructs for regulated expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a regulated promoter operably linked to the coding sequence for a first and second immunoglobulin coding sequence, a sequence encoding a self-processing... Agent: Ropes & Gray LLP

20100151525 - Method for extracting hydrophobin from a solution: Process for extracting hydrophobin from a solution wherein carrageenan is added to the solution and the pH of the solution is brought below 3.5, and the ionic strength of the solution is below 0.5.... Agent: Unilever Patent Group

20100151527 - Fine fibrous cellulosic material and process for producing the same: o

20100151526 - Method of producing sucrose-6-acetate by whole-cell biocatalysis: A process is described which uses whole cell preparations, immobilized or without immobilization, of a microorganism, including Aureobasidium pullulans, capable of forming enzymes of the group of fructosyltransferases, for catalyzing a reaction between sucrose and 6-O-protected glucose for formation of 6-O-protected sucrose, an intermediate in synthesis of trichlorogalactosucrose. 6-O-protected Sucrose... Agent: The Nath Law Group

20100151528 - Methods of producing validamycin a analogs and uses thereof: This disclosure relates to validamycin A biosynthesis and in particular, to methods of producing validamycin A analogs and uses thereof. In a particular example, a method for making a validamycin A analog includes transforming a host cell with one or more recombinant DNA vectors to produce a valN-inactivated mutant; and... Agent: Klarquist Sparkman, LLP

20100151529 - Engineered phosphite dehydrogenase mutants: Phosphite dehydrogenase mutant enzymes provide relaxed cofactor specificity, increased thermostability, increased activity, solubility, and expression over the wild-type enzyme. The mutant enzymes are useful for nicotinamide cofactor regeneration.... Agent: Barnes & Thornburg LLP

20100151530 - Method for producing plasmid dna on a manufacturing scale: A method for producing plasmid DNA on a manufacturing scale uses Escherichia coli K-12 strain JM108. The process results in high yield and homogeneity of plasmid DNA.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100151531 - Method for amplification of dna from blood sample and dna amplification kit therefor: A DNA amplification method including: subjecting a blood sample having DNA to be amplified, to a pretreatment using an alkaline aqueous solution under ordinary temperature, so as to extract double-stranded DNA from the blood sample and dissociate the double-stranded DNA into a single-stranded DNA to obtain a blood-derived sample including... Agent: Sughrue Mion, PLLC

20100151532 - Chondroitin-producing bacterium and method of producing chondroitin: Chondroitin is produced by culturing a UDP-glucuronic acid-producing bacterium transfected with a kfoA gene derived from Escherichia coli K4 strain and a kfoC gene derived from Escherichia coli K4 strain and having chondroitin-producing ability. Chondroitin is collected from the bacterium.... Agent: Knobbe Martens Olson & Bear LLP

20100151533 - Synthesis of (6s)-5methyl-5,6,7,8-tetrahydrofolic acid: A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as... Agent: Pandiscio & Pandiscio, P.C.

20100151536 - Biological synthesis of difunctional alkanes from carbohydrate feedstocks: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production... Agent: Proskauer Rose LLP

20100151534 - Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent: Codexis, Inc.

20100151537 - Modified ethylenediamine-n, n'-disuccinate: ethylenediamine lyase: The present invention provides a modified ethylenediamine-N,N′-disuccinate:ethylenediamine lyase. The present invention also provides a protein that comprises the amino acid sequence represented by SEQ ID NO: 1; or a protein that comprises an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion,... Agent: Darby & Darby P.C.

20100151535 - Renewable chemical production from novel fatty acid feedstocks: Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, interesterification, hydroxylation, hydrolysis and saponification are disclosed. Novel oils containing fatty acid chain lengths of C8, C10, C12 or C14... Agent: Townsend And Townsend And Crew LLP/solazyme, Inc.

20100151538 - Cellulosic cultivation of oleaginous microorganisms: Methods are disclosed for cultivation of oleaginous microorganisms on feedstocks including depolymerized cellulosic material such as corn stover, Miscanthus, forage sorghum, sugar beet pulp and sugar cane bagasse. Also disclosed are methods of manufacturing novel triglyceride oil compositions using cellulosic feedstocks, including oil compositions comprising fatty acids such as those... Agent: Townsend And Townsend And Crew LLP/solazyme, Inc.

20100151540 - Method for processing an algae medium containing algae microorganisms to produce algal oil and by-products: A device and method for processing an algae medium containing algae microorganisms to produce algal oil and by-products thereof. The method comprises pumping the algae medium through a flow-through hydrodynamic cavitation device, generating localized zones of reduced fluid pressure, creating cavitational features in the algae medium, collapsing those cavitation features,... Agent: Kelly Lowry & Kelley, LLP

20100151539 - Recombinant microalgae cells producing novel oils: Disclosed herein are obligate heterotrophic microalgae cells containing an exogenous gene. In some embodiments the gene is a sucrose utilization gene, and further disclosed are methods of manufacturing triglyceride oils using sugar cane or sugar beets as a feedstock in a heterotrophic fermentation. In other embodiments the feedstock is depolymerized... Agent: Townsend And Townsend And Crew LLP/solazyme, Inc.

20100151542 - Cleaning enzymes and fragrance production: The present invention provides compositions comprising an acyltransferase and an alcohol substrate for the acyl-transferase. In some particularly preferred embodiments, the composition finds use in production of a fragrant ester. In some other embodiments, the composition finds use in laundry detergents to clean stains that contain at least one triglyceride.... Agent: Danisco US Inc. Attention: Legal Department

20100151541 - Novel polypeptide having esterase activity and recombinant esterase and use thereof: Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.... Agent: Nixon & Vanderhye, PC

20100151545 - Production of branched-chain alcohols by photosynthetic microorganisms: The present invention provides genes, polypeptides and expression constructs therefor, recombinant photosynthetic microorganisms, and method of use thereof, such as for the production of branched-chain alcohols (including 2-methyl-1-butanol, 3-methyl-1-butanol, and isobutanol) and derivatives thereof for a variety of uses.... Agent: Synthetic Genomics C/o Mofo

20100151543 - Recombinant microorganisms having modified production of alcohols and acids: Recombinant acetogenic Clostridia are engineered to modulate production of aliphatic C2-C6 alcohols and aliphatic C2-C6 organic acids from synthetic gases. One aspect of the invention provides a method of producing an aliphatic C2-C6 alcohol using an acetogenic Clostridium micro-organism having at least one genetic modification that reduces or eliminates C2-C6... Agent: Cardinal Law Group Suite 2000

20100151546 - Systems and methods for producing biofuels and related materials: Clostridium phytofermentans cells (American Type Culture Collection 700394T) and all other strains of the species can ferment materials such as biomass into useful products and coproducts, such as ethanol, hydrogen and organic acids. Compositions that include Clostridium phytofermentans are also disclosed.... Agent: Milstein Zhang & Wu LLC

20100151544 - Systems and methods for selective alcohol production: The present invention relates to metabolic engineering issues related to flux determinism in core primary-metabolism pathways. In particular, the present invention relates to alcohol (e.g., butanol) production and selectivity, and related methods thereof.... Agent: Casimir Jones, S.c.

20100151548 - vector with codon-optimised genes for an arabinose metabolic pathway for arabinose conversion in yeast for ethanol production: The present invention relates to novel expression cassettes and expression vectors, comprising three nucleic acid sequences for araA, araB and araD, each coding for a polypeptide of an L-arabinose metabolic pathway, in particular, a bacterial L-arabinose metabolic pathway. The invention particularly relates to expression cassettes and expression vectors, comprising codon-optimised... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100151549 - Process of producing a fermentation product: The invention relates to a process of producing a fermentation product, such as ethanol, from starch-containing material, including i) subjecting starch-containing material to an alpha-amylase, ii) subjecting the material obtained in step i) to an alpha-glucosidase and/or a maltose-generating enzyme, and iii) fermenting the material in the presence of a... Agent: Swiss Tanner, P.C. P.o. Box 1749

20100151547 - System and apparatus for increasing ethanol production efficiency: The present invention is a system and apparatus for converting cellulosic material into ethanol. Cellulosic material is converted to ethanol using a self-pressurizing fermentation apparatus comprised, in various embodiments, of a pressure tank, pressure sealing means, a pressure gauge, a safety relief valve and a manual relief valve.... Agent: Absolute Technology Law Group LLC

20100151550 - Method for recovering energy from the organic fraction of solid urban waste and associated facility: The invention relates to a method for recovering energy from the organic fraction of urban solid waste comprising the following steps: a) the organic fraction is pre treated with mineral acids, preferably sulfuric acid, during which the fraction is heated by an outer thermal jacket with no steam injection or... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100151551 - Systems and methods for producing biofuels and related materials: Clostridium phytofermentans cells (American Type Culture Collection 700394T) and all other strains of the species can ferment materials such as biomass into useful products and coproducts, such as ethanol, hydrogen and organic acids. Compositions that include Clostridium phytofermentans are also disclosed.... Agent: Milstein Zhang & Wu LLC

20100151552 - Biogas generator: A biogas generator employs an anaerobic digestion process to convert organic waste material within a sealed reservoir to a biogas. A solar thermal panel connected to the reservoir heats a fluid traveling through a conduit, which is connected to a heat exchanger within the reservoir. The heated fluid travels through... Agent: Alston & Bird LLP

20100151553 - Method of detection of bioanalytes by acousto-mechanical detection systems comprising the addition of liposomes: Methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). The detection... Agent: 3m Innovative Properties Company

20100151554 - Enzyme composition and use therefore: The present invention provides an enzyme composition and a method for treating coal using the enzyme composition. The enzyme composition includes at least one enzyme, coenzyme and ammonium acetate, wherein the enzyme can be laccase-isozyme, pyruvate dehydrogenase, dihydrolipoyl transacetylase, and dihydrolipoyl dehydrogenase, and the coenzyme can be CoA, CoA-SH, thiamine... Agent: Pai Patent & Trademark Law Firm

20100151555 - Isoprenoid compounds: The present invention is directed to variant squalene synthase enzymes, including Saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes. These variant enzymes produce squalene at a lower rate than the wild-type enzyme, allowing more farnesyl pyrophosphate to be utilized for production of isoprenoid compounds,... Agent: K&l Gates LLP

20100151556 - Hybrid and single chain meganucleases and use thereof: This patent application relates to hybrid and/or single-chain rare-cutting endonucleases, called meganucleases, which recognize and cleave a specific nucleotide sequence, to polynucleotide sequences encoding for said rare-cutting endonucleases, to a vector comprising one of said polynucleotide sequences, to a cell or animal comprising one of said polynucleotide sequences or said... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100151557 - Method and device for establishing an organism: A method and device for establishing at least one plant in a first growing medium, comprising locating at least one device adjacent a first growing medium such that at least a portion of the or each said device is in contact with said first growing medium, the or each said... Agent: Paul R. Martin

20100151558 - Tubular microbial growth system: Systems and methods for microorganism growth are disclosed. The systems include continuous-culture processes for the growth of large volumes of microorganisms.... Agent: Davis Wright Tremaine LLP - San Francisco

20100151559 - Method and apparatus for transferring heat to or from an organ or tissue container: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the cassette and transporter with heat transfer surfaces arranged to transfer... Agent: Oliff & Berridge, PLC

20100151560 - Compact disk based platform for separating and detecting immunomagnetic bead labeled cells: Disclosed is a disk based platform for separating and detecting cells that are labeled with immunomagnetic beads. A disk-like carrier board forms therein at least one flow channel structure, which includes an inner reservoir for receiving a sample fluid, an outer reservoir, and a plurality of micro flow channels arranged... Agent: Rosenberg, Klein & Lee

20100151561 - Automatic microfluidic processor: In a microfluidic processor with integrated active elements for handling process media, the active elements act by changes in their volume, swelling degree, material composition, their strength and/or viscosity. The procedures to be performed are defined already by the constructive configuration of the microfluidic processor by an appropriate logic connection... Agent: Gudrun E. Huckett Draudt

20100151562 - Biological indicator: A biological indicator for monitoring the effectiveness of a sterilizing or disinfecting treatment or process. A compound or condition is disclosed which comprises a substrate having a surface layer containing functional groups thereon desirably free of silicon linking groups. The functional groups are desirably in the form of a monolayer... Agent: Hudak, Shunk & Farine, Co., L.p.a.

20100151563 - Biological indicator: A biological indicator for monitoring the effectiveness of a sterilizing or disinfecting treatment or process. A compound or condition is disclosed which comprises a substrate having a surface layer containing functional groups thereon desirably free of silicon linking groups. The functional groups are desirably in the form of a monolayer... Agent: Hudak, Shunk & Farine, Co., L.p.a.

20100151564 - Biological work station: A biological work station for culturing and monitoring cells includes a laminar flow bench and an incubator disposed on the bench. The bench includes a work surface adjacent the incubator that allows experiments and other manipulations to be performed within the confines of the laminar flow bench. An imaging system,... Agent: Wisconsin Alumni Research Foundation

20100151565 - Cartridge for automated medical diagnostics: The present invention relates to a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a first component and a second component being connectable to each other, the first component comprising... Agent: Philips Intellectual Property & Standards

20100151567 - Nucleic acids useful in the manufacture of oil: Novel gene sequences from microalgae are disclosed, as well as novel gene sequences useful in the manufacture of triglyceride oils. Also disclosed are sequences and vectors that allow microalgae to be cultivated on sugar cane and sugar beets as a feedstock. In some embodiments, the vectors are useful for the... Agent: Townsend And Townsend And Crew LLP/solazyme, Inc.

20100151566 - Recombinant antibodies against the vascular endothelial growth factor (vegf): The present invention deals with recombinant polypeptide molecules related to antibodies, that specifically recognize the human Vascular Endothelial Growth Factor A (VEGF-A), and interfere with its in vitro stimulatory effects and pro-angiogenic activity in vivo. These recombinant polypeptide molecules affect proliferation of human endothelial cells in vitro, subcutaneous angiogenesis in... Agent: Hoffmann & Baron, LLP

20100151568 - Definitive endoderm: Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.... Agent: Knobbe Martens Olson & Bear LLP

20100151569 - Method of producing a population of cells: A method is provided for producing a population of post-mitotic cells of the neutrophil lineage, which method comprises the ex vivo steps of: (a) providing a population of cells comprising neutrophil progenitor cells; and (b) culturing the population of cells in an animal cell culture medium comprising (i) one or... Agent: Edwards Angell Palmer & Dodge LLP

20100151571 - Centimeter-scale, integrated diagnostics incubator for biological culturing: Disclosed are portable, disposable, centimeter-scale, integrated diagnostics incubators for use in biological culturing. An exemplary incubator comprises an optically accessible enclosure having a plurality of fluidic ports. A heating element is disposed within the enclosure that is coupled to an external heater controller. An autoclavable microfluidic perfusion chamber is disposed... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100151570 - Systems and methods for vitrifying tissue: An apparatus for vitrifying a biological specimen includes a cap member, a tubular plunger, and a specimen chamber. The cap member includes a stem portion integrally formed with a receiving portion. The receiving portion has a disc-like shape and includes an outer surface. The outer surface includes a first skirt... Agent: Tarolli, Sundheim, Covell & Tummino L.L.P.

20100151572 - Anti-tumoral compositions methods: Described are methods and compositions for inhibiting undesired cells by expression of one or more exogenous enzymes in the cells and administration of a prodrug which is a substrate for at least one of the enzymes to produce a cytotoxic compound. Inventive methods and compositions are active to inhibit cells... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20100151573 - Compositions and methods for delivery of molecules to selectin-ligand-expressing and selectin-expressing cells: The present invention is directed to methods for delivery of payload molecules to selected cells. The method comprises payload carrying delivery vehicles tagged with selectin or selectin-ligands. The payload carrying delivery vehicles are immobilized on flow surfaces and payload is delivered to targeted cells during rolling. The invention is also... Agent: Hodgson Russ LLP The Guaranty Building

20100151574 - Multipotent progenitor cell derived from adipose tissue: Disclosed is a cell mass containing an adipose-tissue-derived multipotent progenitor cell. Also disclosed is a method for producing an adipose-tissue-derived multipotent progenitor cell from an adipose tissue, which comprises the steps of: (a) removing erythrocytes from an adipose-tissue-derived cell mass to produce a preadipose-tissue-derived multipotent progenitor cell mass; and (b)... Agent: Mots Law, PLLC

20100151575 - Method of making conditioned media from kidney derived cells: Methods of making conditioned media by culturing cells on nonwoven substrates are disclosed. More specifically, methods of making conditioned media by culturing mammalian kidney-derived cells on nonwoven substrates are disclosed.... Agent: Philip S. Johnson Johnson & Johnson

20100151576 - Targeted tumor therapy by use of recombinant adenovirus vectors that selectively replicate in hypoxic regions of tumors: The presently claimed subject matter provides conditionally replication competent adenoviral vectors that confer selective cytotoxicity on cells expressing HIF-1 by infecting cells that allow HIF-1 inducible promoters present within the vectors to function. Also provided are compositions and host cells based upon the vectors, as well as methods of propagating... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

  
06/10/2010 > patent applications in patent subcategories. invention type

20100143876 - Transplant media: The present invention relates to media containing purified antimicrobial polypeptides, such as defensins, and/or cell surface receptor binding proteins. The media may also contain buffers, macromolecular oncotic agents, energy sources, impermeant anions, ATP substrates. The media find use for the storage and preservation of internal organs prior to transplant.... Agent: Casimir Jones, S.c.

20100143879 - Apparatus and method for filter cleaning by ultrasound, backwashing and filter movement during the filtration of biological samples: The present application is directed to the separation of—a solid fraction from a fluid sample particularly a therapeutic cellular fraction from a biological sample such as a bone marrow sample by a porous filter (2) which separates a filtration unit (1) into an upper pre-filtration chamber (3) into which a... Agent: Diana Houston Smith & Nephew, Inc.

20100143877 - Composition for preserving reproductive cells and method of using: Disclosed are compositions for mammalian, avian or piscian reproductive cells and methods for the collection, holding, processing, in vitro fertilization, sexing culturing, or storing (including long-term cryopreservation) of mammalian or avian reproductive sperm cells. The compositions comprise suitable reproductive cell media and antioxidant bioflavonoids. These may be comprised of Oligomeric... Agent: Boyle Fredrickson S.c.

20100143878 - Methods and kits for isolating cells: Disclosed are methods for differential extraction of a target component from a sample which is predominantly composed of other types of non-target cells that can be lysed using methods that do not lyse the target cells, so that the target material can be purified away from the lysed non-target material.... Agent: Michael Best & Friedrich LLP

20100143880 - Analysis method for determining a functional parameter of an organ using preferably an aqueous 13c-methacetin solution: The invention relates to an analysis method for determining a functional parameter of an organ of a human or animal individual by measuring the 13CO2 content in the air exhaled by the individual to which a substrate has been administered the reaction of which in the body of the individual... Agent: Workman Nydegger 1000 Eagle Gate Tower

20100143887 - Biosensor and method for detecting biomolecules by using the biosensor: Provided are a biosensor and a method for detecting biomolecules by using the biosensor. The biosensor includes a detection unit and a fluid channel. The detection unit is disposed on a substrate and has a surface to which detection target molecules binding specifically to probe molecules are immobilized. The fluid... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100143883 - Capture of mycobacteria like micro-organisms: A method for the capture from a sample of micro-organisms having a hydrophobic surface, which method includes contacting the micro-organisms with a capture reagent, which capture reagent has both a hydrophobic character whereby the capture reagent binds the micro-organisms by hydrophobic interaction therewith and a polar character, the capture reagent... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20100143885 - Detection of human papillomavirus: There is provided an in vitro method of detecting human papillomavirus nucleic acid in a sample, comprising: (a) contacting said sample with forward and reverse oligonucleotide primers, wherein said primers bind to target sites in the human papillomavirus L1 gene, or the complement thereof, under conditions suitable to promote amplification... Agent: Evan Law Group LLC

20100143884 - Detection of influenza virus: The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or... Agent: Townsend And Townsend And Crew, LLP

20100143888 - Enzymatic diagnostic test for sars and other viral diseases: The present invention is directed towards methods, compositions and kits for testing for a virus in a sample. The methods determine the presence of a viral enzyme by contacting the sample with a peptidal compound capable of being cleaved by the viral enzyme to form peptidal compound fragments. Detection of... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100143882 - Improved multiplex nucleic acid amplification using blocked primers: The present invention is in the field of nucleic acid amplification, and in particular in transcription-based amplification, providing improvements thereof. Specifically, the present invention provides primers, and methods for using them, that improve transcription-based amplification reactions, in particular multiplex reactions.... Agent: Myers Bigel Sibley & Sajovec

20100143886 - In vivo hcv resistance to anti-viral inhibitors: HCV mutations emerged in chimpanzees treated with a N5B polymerase inhibitor (Compound A) or a NS3 protease inhibitor (Compound B). Short term treatment with Compound A was followed by the initial emergence of an HCV with a S282T polymerase mutation following treatment. Short term treatment with Compound B selected for... Agent: Merck

20100143891 - Method for the rapid diagnosis of targets in human body fluids: More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.... Agent: Brown & Michaels, PC 400 M & T Bank Building

20100143890 - Peptide compounds for capturing or inhibiting avian influenza virus and application thereof: Disclosed herein are peptide, particularly dipeptide compounds and the application thereof to the detection or inhibition of AI virus. The peptide compounds are more stable and easier to synthesize and store than are antibodies. In addition, having strong binding forces for the H5 protein of AI virus, the peptide compounds... Agent: Staas & Halsey LLP

20100143889 - Rhabdoviridae virus preparations: This document involves methods and materials related to obtaining Rhabdoviridae virus preparations. For example, methods and materials for obtaining large volume, high titer, high purity preparations of Rhabdoviridae viruses (e.g., VSV) with low or non-existent levels of contaminants are provided.... Agent: Fish & Richardson P.C.

20100143881 - Selective detection of human rhinovirus: A process for detecting human rhinovirus nucleic acid in a biological sample, includes producing an amplification product by amplifying an human bocavirus nucleotide sequence using a forward primer of SEQ ID NO: 1, and a reverse primer of SEQ ID NO: 2, and measuring said amplification product to detect human... Agent: Gifford,krass,sprinkle,anderson&citkowsi, PC

20100143892 - Use of ribozymes in the detection of adventitious agents: The present invention provides a method of detecting adventitious agents in a composition comprising a microorganism by using ribozyme-expressing indicator cells, as well as indicator cells useful in such detection.... Agent: Fish & Richardson P.C.

20100143900 - Asynchronous sequencing of biological polymers: The present invention provides methods, reagents and apparatus for conducting single molecule sequencing in an asynchronous manner. The subject methods and compositions are particularly useful for high throughput and multiplexed sequencing.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100143930 - Biological indicator: A biological indicator for monitoring the effectiveness of a sterilizing or disinfecting treatment or process. A compound or condition is disclosed which comprises a substrate having a surface layer containing functional groups thereon desirably free of silicon linking groups. The functional groups are desirably in the form of a monolayer... Agent: Hudak, Shunk & Farine, Co., L.p.a.

20100143915 - Cells modified or altered for a rice-diverged glycosyltransferase: The present invention provides for a cell comprising a modified or altered enzymatic activity of a rice-diverged glycosyltransferase (GT).... Agent: Lawrence Berkeley National Laboratory

20100143928 - Chd7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis: The present invention includes compositions and methods for diagnosis of polymorphisms associated with susceptibility to idiopathic scoliosis in a patient by determining the presence of a mutation in a nucleic acid sample provided from the patient for a mutation in a transcription factor binding site in one or more non-coding... Agent: Chalker Flores, LLP

20100143926 - Classification of patients having diffuse large b-cell lymphoma based upon gene expression: Methods and kits for classifying patients having diffuse large B-cell lymphoma (DLBCL) based upon expression of a plurality of genes are disclosed. Real-time quantitative RT-PCR can be used to measure expression values. Correlating expression values of the plurality of genes in a tumor sample from the patient to reference expression... Agent: Life Technologies Corporation C/o Intellevate

20100143913 - Combined scalable in vitro differentiation system for human blastocyst-derived stem (hbs) cells or cells derived from hbs cells for direct assay application in multiwell plates: A combined scalable in vitro differentiation and assay system based on human blastocyst-derived stem (hBS) cells or cells derived from hBS cells is provided. This system makes it possible to merge both the differentiation and the assay parts of the system into one. The advantage of the combined assay system... Agent: Buchanan, Ingersoll & Rooney PC

20100143925 - Conjugate complexes for analyte detection: The present invention relates to novel conjugate complexes for immunoassays as well as kits comprising these conjugate complexes, methods of producing these complexes, and methods of detecting an analyte by use of these complexes. The conjugate complexes of the invention comprise one or more non-nucleic acid receptors capable of specifically... Agent: Biotechnology Law Group 12707 High Bluff Drive

20100143923 - Detection of methicillin-resistant staphylococcus aureus: This invention relates to the use of genetic probes for detection of the presence of the SCCmec cassette in Staphylococcus aureus. In one aspect, the invention allows specific detection and identification of methicillin-resistant S. aureus (MRSA) in a clinical sample without interference from the presence of other non-S. aureus methicillin-resistant... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100143929 - Dna methylation based test for monitoring efficacy of treatment: A DNA methylation-based test for efficiency of treatments is based on a plurality of genes. The test is suitable for monitoring treatment of subjects with neurological diseases, e.g., multiple sclerosis (MS); with cancer, e.g., breast and ovarian cancer, and with other diseases for which methylation of biomarkers differs in the... Agent: Barnes & Thornburg LLP

20100143917 - Fluorescent chemical compounds having high selectivity for double stranded dna, and methods for their use: Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can... Agent: Life Technologies Corporation C/o Intellevate

20100143919 - In vitro assay for early diagnosis of diabetes mellitus type 1: An in vitro assay is disclosed for early diagnosis of insulin-dependent diabetes mellitus type 1. In at least one embodiment, the assay includes i) determining susceptibility markers for diabetes mellitus type 1 in a biological sample from a symptom-free individual; ii) determining inflammatory markers in the same or in a... Agent: Harness, Dickey & Pierce, P.L.C

20100143897 - Materials and methods for assaying for glyoxylate: The subject invention concerns enzyme-based methods for detecting and assaying for glyoxylate. In particular, the invention is directed to methods for assaying for glyoxylate produced by the reaction of peptidylglycine α-amidating monooxygenase (PAM). The subject invention also concerns methods for assaying for the enzyme peptidylglycine α-amidating monooxygenase. The detection of... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100143906 - Method and computer program product for distinguishing and sorting seeds containing a genetic element of interest: A method for distinguishing and sorting seeds containing a genetic element of interest from a bulk sample. In various embodiments, the present invention comprises associating a marker with at least some of the seeds containing a genetic element of interest of the bulk sample, exciting the seeds using an photonic... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20100143909 - Method for detection of apple mosaic virus, primer set for the detection, and kit for the detection: The invention provides a detection method for apple mosaic virus that comprises an extraction step in which apple mosaic virus RNA is extracted from a specimen, an amplification step in which a primer set containing 4 different oligonucleotides consisting of the nucleotide sequences represented by SEQ ID NO: 1-4 of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100143893 - Method for detection of cytosine methylation: Herein described is a method for the detection of cyto-sine methylation in a nucleic acid sample, comprising the steps of: a) treating a nucleic acid sample with an agent convert-ing unmethylated cytosine bases into uracil bases and not converting methylated cytosine bases within said nucleic acid sample, b) amplifying selected... Agent: Epigenomics Ag

20100143914 - Method for determination of presence of crossing with cultivated rose in wild rose: Disclosed is a method for determining whether or not a wild rose of interest is crossed with a cultivated rose. The method comprises the steps of: examining whether or not a KSN gene containing a transposon (an indicator) is contained in the rose of interest; and determining that the rose... Agent: Drinker Biddle & Reath (dc)

20100143911 - Method for screening essential metabolites in growth of microorganisms: The present invention disclosed is a method for screening metabolites essential for the growth of microorganism using metabolic flux analysis. More specifically, the present invention relates to the method for screening metabolites essential for the growth of microorganism, by selecting a target microorganism, constructing a metabolic network model of the... Agent: Moore & Van Allen PLLC

20100143904 - Method for the genomic typing of erythrocyte systems, oligonucleotide probes and relative diagnostic kits: The invention relates to a method for the genomic typing of erythrocyte systems, oligonucleotide probes and relative diagnostic kits.... Agent: Hedman & Costigan P.C.

20100143927 - Methods and assays for measuring p95 and/or p95 in a sample and antibodies specific for p95: The invention provides methods of measuring and/or quantifying the presence and/or amount of p95 and/or p95 complex in a sample. The invention also provides antibodies specific for p95.... Agent: Kilpatrick Stockton LLP

20100143905 - Methods and compositions for multivalent binding and methods for manufacture of rapid diagnostic tests: The invention provides reagents and methods for multivalent binding and quantitative capture of components in a sample. In one aspect, reagents and methods for diagnostic assay for antigen, ligand, binding agent, or antibody are provided. Compositions of a non-natural or deliberately constructed nucleic acid-like polymeric scaffold are provided, to which... Agent: Klauber & Jackson

20100143902 - Methods and nucleic acids for analyses of cellular proliferative disorders: The invention provides methods, nucleic acids and kits for detecting colorectal cell proliferative disorders based on underexpression or methylation of a least one gene selected from RASSF2, TFAP2E, SND1, PCDHGC3, EDNRB, STOM, GLI3, RXFP3, LimK1, GPR73L1, PCDH1O, DOCKIO and MRPS21, and optionally Septin-9. The invention discloses genomic sequences the methylation... Agent: Davis Wright Tremaine, LLP/seattle

20100143899 - Methods and products for diagnosing cancer: The present invention relates to methods and kits for the detection and diagnosis of cancer or precancerous conditions. Methylation of specific genes has been identified as indicative of cancer and methods of the invention, in part, relate to the detection of methylation levels in cells as a determination of cancer... Agent: Wolf Greenfield & Sacks, P.C.

20100143895 - Methods and systems for adding a reagent to an analyte in a gel: The present invention relates to methods and systems for adding a reagent to an analyte in a gel. The invention further provides methods and systems for transferring liquid analyte reagent mixtures from a gel to a second vessel, such as a microtitre plate. The invention is useful in the manipulation... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100143907 - Methods and uses involving genetic abnormalities at chromosome 12: The present invention relates to the fields of genetics and oncology and provides methods for predicting and identifying tumors of epithelial origin. Specifically, the present invention relates to a novel method of predicting tumor initiation, tumor progression and/or carcinomas, the method comprising detecting genetic abnormality associated with tumors of epithelial... Agent: Ladas & Parry LLP

20100143922 - Methods for reducing over-representation of fragment ends: Methods for preparing fragments for nucleic acids sequence analysis that demonstrates uniform coverage across the full fragment length. The methods disclosed herein are useful for candidate gene re-sequencing wherein the detailed analysis is performed on selected, amplified regions of the genome.... Agent: Lando & Anastasi, LLP

20100143903 - Methods of detecting and monitoring cancer using 3d analysis of centromeres: The present application relates to a method of detecting and monitoring cancer or precancer in a cell using three-dimensional analysis to assess centromere organization. In addition, the application relates to a method and system for characterizing the 3D organization of centromeres.... Agent: Dann, Dorfman, Herrell & Skillman

20100143908 - Multitag sequencing ecogenomics analysis-us: Embodiments of the invention herein described relate to multiplex polynucleotide sequence analysis without the use of size separation methods or blotting. In certain particulars the invention relates to multiplex sequencing using massively parallel sequencing methods, such as pyrosequencing methods and sequencing by synthesis. The invention provides increased throughput, increased accuracy... Agent: Millen, White, Zelano & Branigan, P.C.

20100143924 - Negative correlation between irp-2 and transferrin receptor expression as a diagnostic of alzheimer's disease: A method of diagnosing Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) is disclosed which was identified by the fact that an increased level of iron regulating protein-2 (IRP-2) was identified in Alzheimer's patients. Further, diseases of increased cellular metabolism such as cancer showed high levels of both IRP-2 and... Agent: Knobbe Martens Olson & Bear LLP

20100143901 - Nuclease-free real-time detection of nucleic acids: The invention is a method for amplification and detection of nucleic acids using primers and at least one hybridization probe labeled with a first fluorescent moiety and a second moiety, capable of changing the fluorescence of said first fluorescent moiety. The method comprises the steps of effecting denaturation of said... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100143910 - Nucleic acids probes for detection of yeast and fungal species: The present invention use of to a portion of the RPS7 gene or its corresponding mRNA in a diagnostic assay for fungal and yeast species and sequences for use in such assays and methods.... Agent: Axinn, Veltrop & Harkrider LLP Attn. Michael A. Davitz

20100143916 - Osteoarthritis biomarkers and uses thereof: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the... Agent: Jones Day

20100143921 - Polymorphisms in genes affecting dopamine transporter disorders and uses thereof: A method for predicting a subject's risk factors for dopamine transporter or SLC6A3-related disorders. The method includes detecting the allelic status of one or more polymorphisms in a nucleic acid sample of the subject. The present invention also provides a related kit, comprising an assay for detecting the allelic status... Agent: Macmillan Sobanski & Todd, LLC

20100143894 - Quantitative detection of hdv by real-time rt-pcr: Specific reagents for quantitative assay of HDV and more specifically to follow HDV viral load in chronically infected patients and such a quantitative assay.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100143896 - Sequence capable of enhancing the expression of gene under moderately low temperature: The object is to increase the amount of a protein produced by recombinant DNA method using an eukaryotic cell, particularly a mammalian cell. The object is achieved by using a moderately low temperature transcription control element comprising the nucleotide sequence: X1cccX5X6x7 (wherein x1 represents c t or a; x5 represents... Agent: Birch Stewart Kolasch & Birch

20100143932 - Single molecule sequencing of captured nucleic acids: The invention provides methods and devices for detecting, enumerating or identifying target nucleic acid molecules using immobilized capture probes and single molecule sequencing techniques.... Agent: Brown Rudnick LLP

20100143912 - Specific n-terminal labeling of peptides and proteins in complex mixtures: This invention provides general methods for selective labeling of proteins on their N-termini with synthetic peptides. The methods of this invention can be applied to the global proteomic profiling of complex mixtures of proteins and polypeptides.... Agent: Townsend And Townsend And Crew, LLP

20100143931 - Stable metal/conductive polymer composite colloids and methods for making and using the same: Stable metal/conductive polymer composite colloids and methods for making the same are provided. The subject colloids find use in a variety of different applications, including analyte detection applications. Also provided are kits that include the subject colloids.... Agent: Bozicevic, Field & Francis LLP

20100143920 - Surfactant protein d is a biomarker for steroid responsiveness in asthma and chronic obstructive pulmonary disease: The present invention relates to the identification of a biomarker, the detection of which is prognostic for individuals who are responsive to inhalation of corticosteroids as a therapy for asthma and COPD.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100143918 - Translocation and mutant ros kinase in human non-small cell lung carcinoma: In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in fusion proteins combining part of Sodium-dependent Phosphate Transporter Isoform NaPi-3b protein (SLC34A2) with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The SLC34A2-ROS fusion proteins... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100143898 - Use of products of pcr amplification carrying elements of secondary structure to improve pcr-based nucleic acid detection: Particular aspects comprise amplifying target nucleic acid using PCR and an oligonucleotide primer pair wherein at least one of the primers is designed to incorporate a 5′-specialty sequence to provide for an amplification product that intramolecularly folds into a secondary structure; and detecting the amplification product by a method comprising:... Agent: Davis Wright Tremaine, LLP/seattle

20100143937 - Assay methods for identifying agents that modify the activity of nape-pld or abh4: The present invention provides methods for the detection of agents that modify the activity of the N-acylphosphatidylethanolamine-hydrolysing phospholipase D (NAPE-PLD) enzyme or the Alpha/beta-hydrolase-4 (Abh4) enzyme. The disclosed methods are configured in an assay format amenable to high throughput screening applications.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100143935 - C-kit phosphorylation in cancer: An antibody is disclosed for the detection of phosphorylated c-KIT. A method of diagnosing and monitoring cancers responsive to treatment using an anti-phospho-c-KIT antibody are also disclosed. A diagnostic kit is also provided for the detection and monitoring of cancers responsive to tyrosine phosphorylation inhibitor treatment.... Agent: Baker & Mckenzie LLP

20100143938 - High sensitivity quantitation of peptides by mass spectrometry: The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be... Agent: Perkins Coie LLP

20100143933 - Measurement value lowering inhibitor for immunoassay method and immunoassay method using the same: A measurement value lowering inhibitor for immunoassay method that is capable of enhancing the accuracy of immunoassay method through suppressing of any influences of interfering substances existing in an analyte sample; and using the inhibitor, an immunoassay method in which any measurement value lowering by interfering substances is suppressed and... Agent: Birch Stewart Kolasch & Birch

20100143934 - Modified animal lacking functional pyy gene, monoclonal antibodies that bind pyy isoforms and uses therefor: The present invention provides transgenic animals having a reduced level of expression of peptide YY (PYY) and drug screening platforms using the transgenic animals for identifying agonists and antagonists of PYY. The present invention further provides monoclonal antibodies that bind specifically to full-length PYY[1-36] or the processed form thereof i.e.,... Agent: Fenwick & West LLP

20100143936 - Novel specific arabinose transporter from the yeast pichia stipitis, and uses thereof: The present invention relates to a polypeptide which has a novel specific arabinose transporter function as well as to nucleic acids coding therefore. The invention further relates to host cells, in particular modified yeast strains which contain the coding nucleic acids and express the polypeptide and functionally integrate it into... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100143939 - Intracellular antibodies: The invention related to intracellular single domain immunoglobulins, and to a method for determining the ability of an immunoglobulin single domain to bind to a target in an intracellular environment, comprising the steps of: a) providing a first molecule and a second molecule, wherein stable interaction of the first and... Agent: Edwards Angell Palmer & Dodge LLP

20100143946 - Alpha-synuclein kinase: The invention provides agents and methods for treatment of diseases associated with Lewy body diseases (LBDs) in the brain of a patient. Preferred agents include inhibitors of PLK2 kinase.... Agent: Townsend And Townsend And Crew LLP

20100143943 - Detection of dysplastic or neoplastic cells using anti-mcm2 antibodies: Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the preinitiation complex of DNA replication in tissue, cells or fluid. Target polypeptides include CDC6, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Test samples include tissue of... Agent: Nixon & Vanderhye, PC

20100143945 - Dna-damage-induced proteolysis: The present application provides methods for identifying compounds for inhibiting DNA damage-induced Htt proteolysis, and methods and compositions for protecting cells from DNA damage-induced cleavage of Htt.... Agent: Knobbe Martens Olson & Bear LLP

20100143944 - Systems and methods for rapidly changing the solution environment around sensors: The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention can be applied in any sensor technology in which the sensing element needs to be exposed rapidly, sequentially, and controllably, to a... Agent: Edwards Angell Palmer & Dodge LLP

20100143948 - Chemo-sensitivity assays using tumor cells exhibiting persistent phenotypic characteristics: The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring the progression of an individual patient malignancy. The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring and for identifying cellular and secreted markers, for screening cells to... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100143947 - Reagents and methods for use in cancer diagnosis, classification and therapy: Methods and reagents for classifying HER2+ breast tumors and for identifying new HER2+ breast tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or... Agent: Choate, Hall & Stewart LLP

20100143949 - Biomarkers for colorectal cancer: Low molecular weight (LMW) peptides have been discovered that are indicative of colorectal cancer. Evaluating patient samples for the presence of such LMW peptides is an effective means of detecting colorectal cancer and monitoring the progression of the disease. The LMW peptides are particularly useful in detecting colorectal cancer during... Agent: Foley And Lardner LLP Suite 500

20100143940 - (3r)-hydroxyacyl-acp dehydratase enzymes used in the biosynthesis of mycolic acids and use of same for screening antibiotics: The invention relates to (3R)-hydroxyacyl-ACP dehydratase enzymes involved in the biosynthesis of mycolic acids, and to the use of same for screening antibiotics, medicaments that can be used to treat infections in humans or in animals, caused by Corynebacterineae, more specifically infections caused by pathogenic mycobacteria (Mycobacterium tuberculosis, M. africanum,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100143941 - Devices and methods for detecting analytes: This invention provides devices and methods for detecting an analyte suspected to be present in a sample. The subject devices and methods are particularly useful for performing immunoassays on a variety of analyte, especially those present in a bodily fluid.... Agent: Inverness Medical Innovations / Wsgr Wilson Sonsini Goodrich & Rosati, P.C.

20100143942 - Method of detection: A method of detection of an analyte in which (i) a protein comprising a moiety capable of binding the analyte and a fluorescent label is contacted with a medium suspected of containing the analyte; (ii) the analyte, if present, binds to the moiety; (iii) the protein is subjected to incident... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20100143950 - Binding of complement factor h to c-reactive protein: The invention relates to a correlation between serum complement Factor H levels and binding to C-reactive protein (CRP) and risk of developing age-related macular degeneration. The invention provides methods for screening a subject to assess risk of developing AMD. The invention also provides methods for screening for agents useful to... Agent: Townsend And Townsend And Crew, LLP

20100143952 - Biochip, and method for the selective identification of chlamydia trachomatis infections: The present invention relates to a method for the selective identification of Chlamydia trachomatis infections wherein the antigens CT017, CT098, CT318-L1 P, CT431-TARP, CT603-TSAP, and CT664 are used for the specific identification of Chlamydia trachomatis antibodies in samples from mammals. The method according to the invention facilitates the selective identification... Agent: Smith Patent Consulting, LLC

20100143951 - Novel markers for chronic kidney disease: The present invention relates to a method for the determination or prediction of the progression of chronic kidney disease in a subject suspected to suffer from chronic kidney disease, said method comprising the step of determining the expression levels of at least one marker selected from (a) FGF23; and (b)... Agent: Fulbright & Jaworski L.L.P.

20100143953 - Diagnosis and risk stratification of cardiac insufficiency by means of natriuretic peptides for nyha i patients: The invention relates to a method for the diagnosis, and/or risk stratification, and/or outcome prognosis of cardiac insufficiency for NYHA I patients, wherein a determination of the proANP marker, NT-proANP marker, or fragments or partial peptides thereof is carried out parallel to a determination of BNP, proBNP, and/or NT-proBNP on... Agent: Connolly Bove Lodge & Hutz, LLP

20100143954 - Galectin-3 immunoassay: The present invention relates to methods and compositions for specifically and quantitatively detecting galectin-3 in a sample. Embodiments of the invention include a detection assay in which a capture binding moiety and a labeled binding moiety specifically recognize non-overlapping epitopes on the N-terminus of galectin-3. Further embodiments are directed to... Agent: Goodwin Procter LLP Patent Administrator

20100143955 - Reagent for blood analysis and method of using the same: A reagent for blood analysis includes: (1) a compound having the general formula I; and (2) at least one surfactant selected from cationic surfactants and nonionic surfactants. In another aspect a method for differentiating and counting blood cells is provided, the method includes the following steps: (a) mixing a blood... Agent: Stoel Rives LLP - Slc

20100143956 - Predictive renal safety biomarkers and biomarker signatures to monitor kidney function: Biomarker signatures were identified which can be used to diagnose or predict kidney or liver toxicity and more specifically renal tubular toxicity as a consequence of disease or drug treatment.... Agent: Novartis Corporate Intellectual Property

20100143957 - Methods of measuring adamts13-mediated in vivo cleavage of von willebrand factor and uses thereof: The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods... Agent: Marshall, Gerstein & Borun (baxter)

20100143960 - Cyanine derivatives, fluorescent conjugates containing same and use thereof: L1 and L2 are connecting arms; G is a reactive group; A is a coupling agent; M is a conjugated molecule, W is a phosphate or phosphonate ester (preferably diester), with the proviso that the cyanine derivative comprises at least one L1-W group and at least one L2-A, L2-G or... Agent: Millen, White, Zelano & Branigan, P.C.

20100143958 - Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics: The present invention relates to soluble C-terminal fragments of the adiponectin receptor and their use in the diagnosis and management of disorders.... Agent: Siemens Corporation Intellectual Property Department

20100143959 - Grating based sensor combining label-free binding detection and fluoresnce amplification and readout system for sensor: A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100143961 - Histone deacetylase inhibitors based on alpha-ketoepoxide compounds: Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase... Agent: Steptoe & Johnson LLP

20100143963 - Modular droplet actuator drive: The invention provides a droplet actuator drive. In certain embodiments, the droplet actuator drive may include a detection apparatus for sensing a property of a droplet on a droplet actuator; circuitry for controlling the detection apparatus electronically coupled to the detection apparatus; a droplet actuator cartridge connector; circuitry for controlling... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20100143962 - Nanoparticulate polycosanol formulations & novel polycosanol combinations: The invention provides a culture device comprising a plurality of culture units, wherein each unit comprises a culture chamber, an inlet port for liquid supply of the culture and an outlet port for discharging liquid from the unit, wherein the inlet port is in fluid communication with the culture chamber... Agent: Elan Drug Delivery, Inc. C/o Foley & Lardner

20100143964 - Compositions and methods for concentrating and depleting microorganisms: Methods for concentrating microorganisms in a liquid sample or depleting microorganisms therefrom, utilizing polymeric compounds having affinity to microbial cells that are composed of a plurality of positively charged amino acid residues and two or more hydrophobic moieties are disclosed. Also disclosed are devices for concentrating and methods for detection... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100143967 - Compositions and methods for enhancing the degradation or conversion of cellulose-containing material: The present invention relates to methods for degrading or converting a cellulose-containing material, comprising: treating the cellulose-containing material with an effective amount of a cellulolytic enzyme composition comprising a polypeptide having cellulolytic enhancing activity, and one or more (several) components selected from the group consisting of a CEL7 polypeptide having... Agent: Novozymes, Inc.

20100143966 - Method for facilitating fermentation of high solids compositions: The present invention features a method for facilitating the fermentation of a high solids composition. The method involves subjecting the high solids composition to granular starch hydrolyzing enzyme during the fermentation process to provide a steady source of glucose. Moreover, the instant method is carried out under reduced pressure to... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20100143965 - Method for production of antimutagenic substance using lactic acid bacterium: Disclosed is a method for producing an antimutagenic substance by using a lactic acid bacterium, which can produce the antimutagenic substance in a large quantity in an extremely simple manner and is economically advantageous; particularly a method for producing an antimutagenic substance effective for a carcinogenic substance, particularly a heterocyclic... Agent: Chapman And Cutler

20100143968 - Penicillin-g acylases: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.... Agent: Codexis, Inc.

20100143969 - Expression of soluble, active eukaryotic glycosyltransferases in prokaryotic organisms: The present invention provides enhanced methods of producing soluble, active eukaryotic glycosyltransferases in prokaryotic microorganisms that have an oxidizing environment.... Agent: Townsend And Townsend And Crew, LLP

20100143971 - Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes, Inc.

20100143970 - Transglutaminase having disulfide bond introduced therein: A transglutaminase protein which is mutated to have improved heat resistance and/or pH stability. A mutation is introduced into WT transglutaminase at a cysteine residue capable of forming a disulfide bond (SS bond).... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100143973 - Interleukin-11 fusion proteins: The invention relates to proteins comprising Interleukin 11 (IL-11) (including, but not limited to, fragments and variants thereof), which exhibit thrombopoietic or anti-inflammatory properties, fused to albumin (including, but not limited to, fragments or variants of albumin). These fusion proteins are herein collectively referred to as “albumin fusion proteins of... Agent: Ballard Spahr LLP

20100143972 - Method of making cyclic polypeptides with inteins: Methods for producing cyclic polypeptides comprising a lactone or thiolactone ring. In certain cases, intein fusion proteins may be used in a method for biologically producing internally cyclized polypeptides. The new methods enable the construction of cyclic polypeptide libraries that may be screened for the biological activity of cyclic polypeptides.... Agent: Fulbright & Jaworski L.L.P.

20100143974 - Process for sugar production from lignocellulosic biomass using alkali pretreatment: We have discovered a new method to treat biomass with alkali, for example lime. The lime and lignin was sufficiently removed from the treated biomass b> squeezing with a high pressure device to remove alkali and other potential inhibitors of the cellulase enzymes added for sacchaπfication. The resulting fibrous material... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20100143975 - Monoterpenoid modifying enzymes: Monoterpenoid esters that have been modified to include a sugar pendant group are disclosed. Plant glycosyltransferase enzymes are provided that function to add a sugar, typically glucose, to monoterpenoids in a bioreactor for the production of glycosylated monoterpenoid esters, together with nucleic acid molecules encoding such enzymes and vectors and... Agent: Speckman Law Group PLLC

20100143976 - Process of increasing cellular production of biologically active compounds: A method of increasing production of a methylmalonyl-CoA derivative in a bacterium is disclosed that includes providing a bacterium that produces a methylmalonyl-CoA derivative in which methylmalonyl-CoA mutase function has been inhibited and culturing the bacterium in a medium containing an effective amount of methylmalonyl-CoA or a precursor thereof to... Agent: Quarles & Brady LLP

20100143977 - Genetically modified strains producing anthracycline metabolites useful as cancer drugs: The invention refers to a microbial strain, which produces anthracycline metabolites at a titre of at least 0.5 g/l fermentation broth.... Agent: Briscoe, Kurt G. Norris Mclaughlin & Marcus, Pa

20100143978 - Process for manufacture of optically active 2-(acyloxymethyl)-1,3-oxathiolanes: There is provided a process for manufacture of optically-active, 2-(acyloxymethyl)-1,3-oxathiolanes of Formula I comprising a preparation of a racemic compound and an enzyme-catalyzed kinetic resolution of the enantiomers. The invention may further provide for the esterification and racemization of the by-product of the enzymatic reaction. In this manner, 2(R)-(benzoyloxymethyl)-1,3-oxathiolane is... Agent: Brouse Mcdowell Lpa

20100143979 - Polypeptides having dna polymerase activity: A polypeptide having a high fidelity DNA polymerase activity and thus being useful as a genetic engineering reagent; a gene encoding this polypeptide; a method of producing the polypeptide; and a method of amplifying a nucleic acid by using the polypeptide.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100143980 - Synthesis of novel xylosides and potential uses thereof: The present invention includes a xyloside for use in inducing synthesis of a glycosaminoglycan in a cell, the xyloside having a chemical structure of one of Formula (1), Formula (2), Formula (3), Formula (4), Formula (5), Formula (6), Formula (7), Formula (8), Formula (9), or Formula (10) as shown herein.... Agent: Workman Nydegger 1000 Eagle Gate Tower

20100143981 - Whole-cell catalytic system comprising a hydantoinase, a racemase and a carbamoylase: The present invention relates to a whole cell catalytic system for the preparation of an enantiomerically enriched α-amino acid from a corresponding hydantoin wherein hydantoinase, L-carbamoylase and hydantoin racemase are coexpressed in a recombinant micro-organism wherein the genes coding for these three enzymes are located on a single replicon. The... Agent: Nixon & Vanderhye, PC

20100143982 - Method for producing an l-amino acid using a bacterium of enterobacteriaceae family with attenuated expression of the aldh gene: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the aldH gene.... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100143983 - Method for producing l-arginine using a bacterium of enterobacteriaceae family, having attenuated expression of a gene encoding an l-arginine transporter: The present invention provides a method for producing L-arginine using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of one or several genes encoding an L-arginine transporter.... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100143984 - Corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same: A variant of Corynebacterium shows activity greater than the endogenous activity of aspartate aminotransferase, aspartate kinase, aspartate semialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydropicolinate reductase and diaminopimelate dicarboxylase and additionally pyruvate carboxylase. The variant is used in a method of producing L-lysine.... Agent: Knobbe Martens Olson & Bear LLP

20100143985 - Method for preparing butanol through butyryl-coa as an intermediate using yeast: Disclosed herein are a method for producing butanol in yeast having the ability to biosynthesize butanol using butyryl-CoA as an intermediate, the method comprises producing butyryl-CoA in yeast having a CoAT (acetyl-CoA:butyryl-CoA CoA-transferase)-encoding gene introduced thereinto, through various pathways, and then converting the produced butyryl-CoA to butanol.... Agent: Moore & Van Allen PLLC

20100143986 - R-hnl random variants and their use for preparing optically pure, sterically hindered cyanohydrins: The invention relates to R-hydroxynitrile lyases with improved substrate acceptance, increased activity and increased selectivity, obtainable by introducing random mutations with the aid of random mutagenesis and/or saturation mutagenesis techniques, identifying by means of screening or selection and, where appropriate, subsequently combining advantageous mutations, and to the use thereof.... Agent: Hoxie & Associates LLC

20100143987 - Process for preparing glycerol esters: There is provided a process for the preparation of a compound of the formula, wherein one of R1, R2 and R3 is selected from groups R6, R7 and R8; wherein two of R1, R2 and R3 are independently selected from groups R9, R10 and R11, the process comprising the step... Agent: Steptoe & Johnson LLP

20100143988 - Thermoanaerobacter mathranii strain bg1: Strict anaerobic thermophilic bacterium belonging to the group of Thermoanaerobacter mathranii and mutants and derivatives thereof. The bacterium is particularly suitable for the production of fermentation products such as ethanol, lactic acid, acetic acid and hydrogen from lignocellulosic biomass.... Agent: Roberts Mlotkowski Safran & Cole, P.C. Intellectual Property Department

20100143989 - Production of 3-hydroxycarboxylic acid using nitrilase mutants: This invention relates to nitrilase mutants having improved nitrilase activity for converting 3-hydroxynitriles to 3-hydroxycarboxylic acids. More specifically, the Acidavorax facilis 72W (ATCC 55746) nitrilase gene was mutated using error-prone PCR and site-directed mutagenesis to create nitrilase enzymes having improved nitrilase activity for converting 3-hydroxynitriles (e.g., 3-hydroxybutyronitrile or 3-hydroxyvaleronitrile) to... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20100143990 - Fermentative production of hydroxytyrosol: The present invention relates to a newly identified microorganisms capable of direct production of hydroxytyrosol (hereinafter also referred to as Hy-T) from a carbon source obtainable from the D-glucose metabolization pathway. The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of... Agent: Nixon & Vanderhye, PC

20100143991 - Method for producing optically active alcohols using an azoarcus sp. ebn1 dehydrogenase: A method for producing optically active alcohols of formula (Ia) or (Ib), wherein R1, R2 are alkyl, alkenyl, aryl, or alkylaryl groups, which in turn can be mono-substituted or poly-substituted with alkyl, halogen, SH, SR2, OH, OR2, NO2, CN, CO, COOR2, NR2R3 or NR2R3R4+X, wherein R2, R3 and R4 independently... Agent: Connolly Bove Lodge & Hutz, LLP

20100143996 - Continuous single vessel butanol synthesis by fermentation: The present invention describes a method for producing butanol by fermentation of carbohydrates using mixed populations of acidogenic-phase cells and solventogenic-phase cells of Clostridium in a solitary vessel. The present system as described does not require intermittent adjustment of pH or venting of headspace gases. The method provides a process... Agent: Mdip LLC

20100143997 - Engineered microorganisms capable of producing target compounds under anaerobic conditions: The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100143992 - Process for fermentive preparation of alcohols and recovery of product: This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100143994 - Process for fermentive preparation of alcohols and recovery of product: This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100143995 - Process for fermentive preparation of alcohols and recovery of product: This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100143993 - Process for fermentive preparationfor alcolhols and recovery of product: This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100143998 - Systems and methods for producing biofuels and related materials: Clostridium phytofermentans cells (American Type Culture Collection 700394T) and all other strains of the species can ferment materials such as biomass into useful products and coproducts, such as ethanol, hydrogen and organic acids. Compositions that include Clostridium phytofermentans are also disclosed.... Agent: Milstein Zhang & Wu LLC

20100144001 - Ensiling biomass for biofuels production and multiple phase apparatus for hydrolyzation of ensiled biomass: A method, apparatus and system for the hydrolyzation of ensiled biomass is disclosed. Ensiled biomass is processed in multiple phases, resulting in a liquid precursor hydrozate and a solid precursor hydrozate. The liquid precursor having significant economic value, and being suitable for uses such as, for example, lower cost and... Agent: Robert D. Gunderman, Jr. Patent Technologies, LLC

20100144000 - Process for fermentive preparation fo alcohols and recovery of product: This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100143999 - Process for fermentive preparation of alcohols and recovery of product: This invention relates to a process for recovering an alcohol from a fermentation broth using liquid-liquid extraction, wherein at least one ionic liquid is used as the extractive solvent.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100144003 - Induction of microbial secondary metabolites: The present invention relates to the production of secondary metabolites from microorganisms. In particular, there are provided methods for inducing the rapid production of such compounds from a variety of microorganisms.... Agent: Davis Wright Tremaine LLP/los Angeles

20100144002 - Methods for accelerating tissue processing: Systems and methods for accelerating tissue processing by treating tissue samples and one or more tissue processing agents with infrasonic vibrations are discussed. Some non-limiting examples of tissue processing agents include a tissue fixative, dehydrating agent, clearing agent, impregnating agent, embedding agent, tissue stain, enzyme, or another chemical that diffuses... Agent: Kirton And Mcconkie

20100144004 - Cell culture system, cell culture substrate thereof and culture method thereof: A cell culture system for directing growth of cells is provided. The cell culture system includes a substrate, a culture layer and a culture medium. The culture layer is located on the substrate. The culture layer includes at least one carbon nanotube film including a plurality of carbon nanotubes orientated... Agent: PCe Industry, Inc. Att. Steven Reiss

20100144005 - Process for isolating microorganisms from samples and system, apparatus and compositions therefor: A process for isolating microorganisms from samples, particularly Shigella spp. from food samples, and a system, apparatus and composition therefor are provided. Magnetic particles are used to capture microorganisms and a system having separate magnetically-based apparatuses for collecting, concentrating and retrieving is used to isolate the magnetic particles having bound... Agent: National Research Council Of Canada

20100144006 - Sample concentration method and apparatus: A method and apparatus for controlled concentration of an analyte containing liquid sample. Embodiments include using microwave energy to heat a sample while reducing pressure in a chamber. The combination of reduced pressure and microwave energy can provide sufficient heat to vaporize a portion of the liquid while maintaining analyte... Agent: Charm Sciences, Inc.

20100144007 - Apparatus and methods for loading soft materials: The present invention provides an apparatus for loading soft materials and methods for using the same. In some embodiments, the apparatus is a gearless mechanical loading apparatus which converts a rotational movement of one end of a first element into an arc of a circle movement of the other end... Agent: Don D. Cha

20100144008 - Treatment of fabry disease: A pathogenic factor in plasma as an improved therapy for Fabry disease.... Agent: Young & Thompson

20100144009 - Extracting and purifying lipoxygenase: The present invention relates to the extraction and purification of lipoxygenase from plant matter, including soy beans. A process for purifying lipoxygenase from plant matter is provided.... Agent: Ballard Spahr LLP

20100144010 - Enzymatic asymmetric decarboxylation of disubstituted malonic acids: A process for the stereoselective decarboxylation of malonic acid derivatives with mutated decarboxylases is disclosed.... Agent: Cermak Kenealy Vaidya & Nakajima LLP

20100144011 - Crystal growth under microgravity condition: The present invention relates to the growth of protein crystallization on earth and in zero-gravity conditions. Moreover, the invention relates to preferred conditions to develop protein crystals or 3D crystal structures. Furthermore, the preferred embodiment of the present invention relates to an evaluation of 3D crystal growth under microgravity (zero-gravity)... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20100144012 - Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof: A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y and a second variant of I-CreI variant having the amino acid sequence of accession number pdb 1g9y in a single polypeptide.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100144013 - Over expression of foldases and chaperones improves protein production: The present teachings provide methods for increasing protein secretion, e.g., chymosin in filamentous fungi by co-expressing certain chaperone(s) and/or foldase(s). The present teachings also provide filamentous fungi containing certain chaperone(s) and/or foldase(s) and a protein of interest for increased secretion.... Agent: Danisco US Inc. Attention: Legal Department

20100144015 - Compositions, methods and uses for inducing viral growth: Embodiments herein report methods, compositions and uses for inducing and/or accelerating viral growth. In certain embodiments, methods, compositions and uses generally related to copolymer compositions for inducing viral growth, reducing lag time and/or increasing viral plaque size. In other embodiments, methods, compositions and uses of copolymer compositions can be for... Agent: Faegre & Benson LLP Patent Docketing - Intellectual Property

20100144014 - Method for amplifying hcv in aedes mosquitoes: b

20100144016 - Apparatus for the disruption of animal cells: The present invention relates to the field of purifying recombinant virus propagated in animal cells. More particularly, it relates to a method for extracting virus from virus-infected cells that have been grown in culture in order to release virus and to apparatus for extracting virus from virus-infected cultured cells using... Agent: Glaxosmithkline Corporate Intellectual Property - Uw2220

20100144017 - System for harvesting algae in continuous fermentation: The present invention is a system for harvesting algae in continuous fermentation. There is a harvester including a main moving belt, a plurality of rollers, and a motor for driving the main moving belt. There is a reactor tank and a vacuum extractor for applying a vacuum over a width... Agent: Egbert Law Offices

20100144018 - Automated slide staining apparatus: A slide stainer assembly is disclosed. The slide stainer includes a slide carrier that is configured to carry one or more laboratory slides and a plurality of slide processing stations for processing the slides. A transport member including a plurality of engagement portions is configured for releasably engaging the slide... Agent: Ratnerprestia

20100144019 - Photobioreactor: A photobioreactor used for microalgal culture consists a main body of bioreactor, a plurality of built-in light sources, a mechanical stirring apparatus and a pneumatic mixing device. The main body of the bioreactor is a hollow chamber and the plurality of built-in light sources connects the chamber from outside to... Agent: Rosenberg, Klein & Lee

20100144020 - Disposable diagnostic kit: Provided is a disposable diagnostic kit capable of diagnosing diseases. The disposable diagnostic kit includes a preprocessor, a target material reactor, and a microfluidic channel. The preprocessor filters target materials from a fluid containing various biomaterials. The target material reactor includes a diffraction grating on whose surface sensing materials reacting... Agent: Ampacc Law Group

20100144021 - Bio-driver apparatus for detecting a nucleic acid: A cleavable signal element applicable to quantitative and qualitative assay devices, using a cleavable technique specifically responsive to a complementary double strand or single strand of nucleic acids, and a nucleic acid hybridization assay method and device using the cleavable signal element are provided. Using the cleavable technique responsive to... Agent: Staas & Halsey LLP

20100144022 - Continuous flow bioreactor: The present invention is directed toward bioreactor systems capable of causing internal contents to have an angular motion throughout the bioreactor container without rotating the container. In one embodiment, the bioreactor system has a base platform, including three areas, a toroidal container removably attached to the base platform, a three... Agent: Patentmetrix

20100144023 - Photobioreactor: A photobioreactor system including a light source, a plurality of interconnected pipes, and a liquid slurry containing an algae disposed within the pipes. The pipes are formed from a translucent polyvinyl chloride material that allows light having a plurality of wavelengths emitted from the light source that stimulate growth of... Agent: Harness, Dickey & Pierce, P.L.C

20100144024 - Replica moulding of microstructures for supporting microscopic biological material: A method of replica moulding microstructures, the method including forming a negative master of at least one microstructure configured to support microscopic biological material, casting a flowable polymeric material onto the negative master, placing a substrate against the flowable polymeric material and the negative master, allowing the flowable polymeric material... Agent: Seed Intellectual Property Law Group PLLC

20100144029 - Facilitating protein solubility by use of peptide extensions: Expression vectors for expression of a protein or polypeptide of interest as a fusion product composed of the protein or polypeptide of interest fused at one terminus to a solubility enhancing peptide extension are provided. Sequences encoding the peptide extensions are provided. The invention further comprises antibodies which bind specifically... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20100144025 - Hla-binding peptide, precursor thereof, dna fragment and recombinant vector encoding the same: There is provided an HLA-binding peptide being excellent in binding affinity to an HLA-A type molecule. An HLA-binding peptide capable of binding to an HLA-A type molecule, including one or more amino acid sequences selected from the group consisting of SEQ ID NOs: 1 to 50, and being composed of... Agent: Sughrue Mion, PLLC

20100144028 - Method and device for continuous membrane adsorption: A method and system is provided for yielding biopharmaceutical products involving a chromatographic separation process. The method comprises: providing a plurality of membrane adsorber cartridges; providing a plurality of valves, communicatively coupled to said plurality of membrane adsorber cartridges; and switching the valves, so as to interconnect said membrane adsorber... Agent: Leydig Voit & Mayer, Ltd

20100144027 - Placental protein having a regulating action on proteolytic activity and its related gene: The present invention is intended to provide a novel pharmaceutical composition containing a protein that does not have a known protein motif structure but has proteolytic activity and regulating action on the activity of other proteases, cell invasiveness and smooth muscle contraction and relaxation, and is capable of treating, preventing... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100144026 - Sirna-mediated gene silencing with viral vectors: The present invention is directed to viral vectors encoding small interfering RNA molecules (siRNA) targeted against a gene of interest, and methods of using these viral vectors.... Agent: Viksnins Harris & Padys Pllp

20100144030 - Method and apparatus for gender selection based on ph: The present invention includes methods and apparatus to separate X or Y-chromosome bearing sperm cells in a population by first placing the population of sperm cells at physiological pH environment, and simultaneously contacting the population of sperm cells with one or more additional sub-environments with different pH values. The exposure... Agent: Chalker Flores, LLP

20100144031 - Methods for reprogramming somatic cells: The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated... Agent: Morse, Barnes-brown & Pendleton, P.C. Attn:IPManager

20100144032 - Process for isolating vascular endothelial cells from embryoid bodies differentiated from embryonc stem cells: The present invention provides a process for isolating vascular endothelial cells from embryoid bodies differentiated from embryonic stem cells, which comprises: (a) treating embryoid bodies differentiated from embryonic stem cells with 0.005-0.015% trypsin and 0.05-0.15 mM ethylenediaminetetraacetate (EDTA) to obtain vascular endothelial cell clusters; and (b) treating the vascular endothelial... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100144033 - Suspension culture of human embryonic stem cells: This disclosure provides an improved system for culturing human embryonic stem cells. The cells are cultured in suspension so as to maximize the production capacity of the culture environment. The new culture system of this invention allows for bulk proliferation of hES cells in a more cost-effective manner, which facilitates... Agent: Geron Corporation Attn. David J. Earp

20100144034 - Method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene: There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells in vitro, which... Agent: Robins & Pasternak

20100144035 - Delivery system for nucleic acids using cationic polymer conjugates: The present invention relates to a delivery system for nucleic acid using a cationic polymer conjugate, and more specifically relates to a delivery system for nucleic acid comprising a cationic polymer conjugate prepared by conjugating hyaluronic acid or its derivative and polyethyleneimine, and a composition of delivering a nucleic acid... Agent: LexyoumeIPGroup, LLC

20100144036 - Isolation of cells: The invention relates to a method for isolating cells from a tissue sample. In preferred embodiments, chondrocytes are isolated from cartilage tissue in a shorter time than hitherto considered possible.... Agent: Morrison & Foerster LLP

20100144037 - Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling: A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication with the cellular growth area allows for hermetically... Agent: Caridianbct, Inc. Mail Stop: 810 1f2

20100144040 - Cells and methodology to generate non-segmented negative-strand rna viruses: The present invention relates to recombinant cells as well as to methods for the generation of non-segmented negative-sense single-stranded RNA viruses (NNV or mononegavirales) from cloned deoxyribonucleic acid (cDNA), especially from measles virus and in particular from attenuated strains such as those approved for vaccination, in particular from the attenuated... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100144038 - Composition and method for increasing efficiency of introduction of target substance into cell: The present invention provides a method capable of improving the efficiency of introducing a target substance (e.g., DNA, polypeptides, sugars, or complexes thereof), which is difficult to introduce (particularly, transfect) into a cell in any circumstances. Particularly, the present invention provides a composition for increasing the efficiency of introducing a... Agent: Seed Intellectual Property Law Group PLLC

20100144039 - Pluripotency determining factors and uses thereof: Pluripotency determining factors are described which act intracellularly and maintain a pluripotent cell in a pluripotent state in the absence of gp130 activation, which maintain or confer pluripotency of a human stem cell, which maintain or confer pluripotency of a mouse ES cell, and which maintain or confer pluripotency of... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100144041 - l-arabinose fermenting yeast: An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the... Agent: Paul J White, Patent Counsel National Renewable Energy Laboratory (nrel)

  
06/03/2010 > patent applications in patent subcategories. invention type

20100136512 - Embryo culture media containing thyroid hormone: The disclosure relates to the use of culture media containing thyroid hormones or analogs thereof, and includes methods and uses thereof for embryo culture, embryo production, embryo maturation, improved survival of embryos and improved viability of embryos post cryopreservation.... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20100136518 - Antibodies useful for therapy and diagnosis of cancer: The present invention provides antibodies, or fragments thereof, for isolating and/or identifying epitopes of an endogenous retrovirus, preferably of a melanoma associated endogenous retrovirus, and hybridoma cells producing said antibodies. The antibodies are useful especially for the treatment and diagnosis of cancer. Further, the present application covers diagnostic kits for... Agent: Sheldon Mak Rose & Anderson PC

20100136513 - Assay for sars coronavirus by amplification and detection of nucleocapsid rna sequence: Primers and probes derived from SARS-CoV nucleic acid that facilitate detection and/or quantification of the nucleocapsid gene are disclosed. The disclosed sequences may be used in a variety of amplification and non-amplification formats for detection of SARSCoV infection.... Agent: David W. Highet Becton, Dickson And Company

20100136515 - Compositions for use in identification of papillomavirus: The present invention relates generally to identification of HPV, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent: Abbott Laboratories C/o Polsinelli Shughart PC

20100136520 - Detecting hepatitis b virus: This invention is related to methods for detecting hepatitis B virus by determining the level of hepatitis B virus surface antigen protein. This invention is also related to methods for detecting mutant hepatitis B virus surface antigen protein and kits for detecting hepatitis B virus.... Agent: Paul D. Yasger Abbott Laboratories

20100136519 - Determination of a specific immunoglobulin using multiple antigens: The invention concerns a process for the immunological determination of a specific antibody in a fluid sample. The process involves incubating the fluid sample in the presence of a solid phase with two antigens directed against the antibody whose presence is to be determined; the first antigen carries at least... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100136521 - Devices and methods for detection of microorganisms: The present invention features methods and devices for microorganisms through detecting Mie light scattering from immunoagglutinated beads. The methods feature providing a first bead suspension with antibody specific for the microorganism conjugated to beads; mixing the first bead suspension with a sample to form a first mixture; irradiating the first... Agent: Nguyen & Tarbet

20100136514 - Infectious clone of human parvovirus b19 and methods: The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infectious clones are useful for producing infectious virus. Infectious... Agent: Edwards Angell Palmer & Dodge LLP

20100136517 - Matrix stabilization of aggregation-based assays: Methods and apparatus for stabilization of aggregation-based assays are described. In various embodiments, anti-analytes are dispersed within a matrix. A solution containing analytes brought into contact with the matrix, so that analytes may permeate throughout at least a portion of the matrix. In some embodiments, the anti-analytes and analytes are... Agent: Choate, Hall & Stewart LLP

20100136516 - System and method for detection of hiv integrase variants: An embodiment of a method for detecting low frequency occurrence of one or more HIV sequence variants associated with integrase is described that comprises the steps of: (a) generating a cDNA species from a plurality of RNA molecules in an HIV sample population; (b) amplifying a plurality of first amplicons... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris, Glovsky And Popeo,

20100136532 - Aqp5 polymorphism: In order to predict disease risks, disease courses and the response of an individual patient to pharmacological and non-pharmacological therapies a polymorphism in the AQP5 gene has been investigated, in particular in the promoter region of said gene,on the human 12q13 chromosome, wherein the therapy can also be a cosmetic... Agent: Amster, Rothstein & Ebenstein LLP

20100136544 - Assays and other reactions involving droplets: The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments, the droplet or emulsion may be hardened to form a gel. In some aspects, a heterogeneous assay can be performed using... Agent: Harvard University & Medical School C/o Wolf, Greenfield & Sacks, P.C.

20100136555 - Burkholderia pseudomallei diagnostic genetic elements that predict mortality in melioidosis: The present invention provides methods for predicting the likelihood of mortality from melioidosis and detecting the presence of Burkholderia pseudomallei in a test sample.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100136558 - Canine cd20 gene: It is intended to clarify the CD20 amino acid sequence and its gene sequence which are essentially required in constructing an anti-CD20 antibody useful in treating animal malignant lymphoma. It is also intended to provide a method of diagnosing canine malignant lymphoma by using the CD20 gene sequence. Using monocytes... Agent: Young & Thompson

20100136559 - Chromatin structure detection: The present application provides methods and compositions for determining accessibility of a DNA modifying agent in genomic DNA.... Agent: Townsend And Townsend And Crew, LLP

20100136565 - Compositions and methods for diagnosing autism: Mutations located within the gene encoding the homeobox transcription factor, ENGRAILED 2 (EN2), have now been identified as molecular markers associated with susceptibility for autism and related disorders. Thus, the present invention relates to compositions in the form of diagnostic kits, primers and target sequences, for use in methods for... Agent: Licata & Tyrrell P.C.

20100136568 - Compositions and methods for regulating rna translation via cd154 ca-dinucleotide repeat: Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of hnRNP L with the CA-dinucleotide rich sequence of the 3′-untranslated region of CD154.... Agent: Licata & Tyrrell P.C.

20100136569 - Compositions, methods and kits for polynucleotide amplification reactions and microfluidic devices: Antifoam agents improve detection of polynucleotide amplification reactions and improve manipulation of fluids in microfluidic devices.... Agent: Townsend And Townsend And Crew, LLP

20100136533 - Compound containing farnesyl diphosphate for modulating trpv3 function and use thereof: The present invention relates to a method for activating TRPV3 (transient receptor potential vanilloid 3) using FPP (farnesyl diphosphate) and a method for screening a TRPV3 activity inhibitor. FPP of the present invention has TRPV3 specific activity and therefore it can be effectively used for the study on TRPV3 mechanism... Agent: Greenlee Winner And Sullivan P C

20100136567 - Cyanine dyes: The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.... Agent: Morgan, Lewis & Bockius LLP (sf)

20100136545 - Cytokines and genes differentially affected by tnf blockers: The present invention is directed to cytokines and genes that are differentially affected by TNF blockers and the use of these genes and cytokines to help asses the TB risks of new immunosuppressive therapies, to help evaluate the effects of new TB vaccines, and to help assess TB susceptibility in... Agent: Patent Docket Administrator Lowenstein Sandler PC

20100136556 - Detection device for detecting biological microparticles such as bacteria, viruses, spores, pollen or biological toxins, and detection method: A device for the detection of micro particles that can be marked by probes or antibodies capable of being detected by radiation has a filter, a supply system, and a detection system. Fluid to be examined is passed over a filter to filter out the micro particles and to perform... Agent: GlobalIPCounselors, LLP

20100136527 - Dominant b cell epitopes and methods of making and using thereof: Disclosed are methods for obtaining at least one epitope suitable for detecting the presence of an antibody against a tumor associated antigen of a cancer in a sample. Kits, assays, and substrates employing the epitopes of the present invention are disclosed. Also disclosed are epitopes of NY-ESO-1 and XAGE-1b and... Agent: Suzannah K. Sundby (uc) Smith, Gambrell & Russell, LLP

20100136522 - Endogenous retroviruses up-regulated in prostate cancer: Human endogenous retroviruses of the HML-2 family show up-regulated expression in prostate tumors. This finding can be used in prostate cancer screening, diagnosis and therapy.... Agent: Novartis Vaccines And Diagnostics Inc.

20100136539 - Ezrin assay method for the in vitro diagnosis of colorectal cancer: A method for the in vitro diagnosis of colorectal cancer by determining the presence of the Ezrin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer using at least one anti-Ezrin monoclonal antibody directed against an Ezrin epitope chosen from the epitopes of sequence... Agent: Oliff & Berridge, PLC

20100136528 - Fiat nucleic acids and proteins and uses thereof: The invention provides FIAT nucleic acids and proteins, and methods of using such nucleic acids and proteins.... Agent: Fish & Richardson PC

20100136525 - Fluid analysis device and method: The invention provides an analysis device (1) and method, that enables repeatedly pumping a sample fluid (50) with one or more analytes through a substrate (10) with one or more binding materials, even when the wetted substrate has a relatively low bubble pressure. Thereto, the device (1) comprises a first... Agent: Philips Intellectual Property & Standards

20100136546 - Genetic marker for adverse behavioral conditions: The present invention concerns genetic marker for adverse behavioral conditions. In particular aspects, the marker is present at chromosome 15q13 and comprises CHRNA7. In certain cases, the marker is a microdeletion or point mutation in CHRNA7.... Agent: Fulbright & Jaworski, LLP

20100136561 - Genetic markers for weight management and methods of use thereof: This application relates to methods and tests that allow for the establishment of personalized weight-loss programs for a subject based upon the subject's metabolic genotype in key metabolic genes. Kits and methods are disclosed for determining a subject's metabolic genotype, which may be used to select an appropriate therapeutic/dietary regimen... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100136541 - Identification and verification of methylation marker sequences: The present invention relates to methods for identifying among the genes that are down-regulated in cells or tissues having disease including cancer, the CpG sites within the CpG islands of said genes, wherein the identified CpG sites show great potential for diagnostic utility. In another aspect, the present invention also... Agent: Siemens Corporation Intellectual Property Department

20100136560 - Integrated analyses of breast and colorectal cancers: Genome-wide analysis of copy number changes in breast and colorectal tumors used approaches that can reliably detect homozygous deletions and amplifications. The number of genes altered by major copy number changes—deletion of all copies or amplification of at least twelve copies per cell—averaged thirteen per tumor. These data were integrated... Agent: Banner & Witcoff, Ltd.

20100136566 - Lateral flow strip assay with immobilized conjugate: The present invention discloses analyte detection devices for detecting one or more analytes present in test samples, especially biological samples. In particular, the devices of the invention are lateral flow assay devices comprising immobilized metal nanoparticle conjugates as the detection means. Methods of using the devices and kits comprising the... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100136538 - Marking reagents bearing diazo and nitro functions, methods for the synthesis of such reagents and methods for detecting biological molecules: The present invention also describes a method of synthesizing said markers and also applications for the labeling of biological molecules, more particularly nucleic acids, with a labeling reagent bearing diazo and nitro functions. The invention is particularly suitable for use in the diagnostics field.... Agent: Oliff & Berridge, PLC

20100136535 - Means and methods for detecting protein-peptide interactions: A novel method of detecting and characterizing protein-peptide interactions is provided, which can be used for isolating peptides and proteins, respectively, as well as in drug screening and development.... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100136543 - Method for determining the genotype at the crohn's disease locus: The present invention refers to a method for determining the genotype of an individual at the 5p13.1 Crohn's disease risk locus, the method comprising: providing a sample from the individual; determining whether a DNA sequence corresponding to a DNA sequence polymorphism located between coordinated 40,300,000 and 40,600,000 of human chromosome... Agent: Knobbe Martens Olson & Bear LLP

20100136534 - Method of identifiying a serotype of klebsiella pneumoniae and application thereof: The present invention relates to a method of identifying a serotype of Klebsiella pneumoniae, in particular to a method using specific polymerase chain reaction (PCR) primer sets designed according to a fragment of a capsular polysaccharide synthesis (cps) region to identify a K57 or a NTUH-N1 serotype and its application.... Agent: Wpat, PC Intellectual Property Attorneys

20100136540 - Methods and compositions for characterizing patients for clinical outcome trials: The invention provides with methods for characterizing and selecting, within a population of subjects with type-2 diabetes, subjects that are suited for clinical trials based on the identification of one or more genetic features, which are single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), and/or other genomic markers. The invention... Agent: Millen, White, Zelano & Branigan, P.C.

20100136552 - Methods and compositions for dmxl-associated mental retardation: The present invention provides a method of identifying a human subject as having an increased likelihood of having DMXL-associated mental retardation, comprising detecting, in a nucleic acid sample from the subject, a mutation in a nucleotide sequence encoding DMXL1 and/or a mutation in a nucleotide sequence encoding DMXL2. The present... Agent: Myers Bigel Sibley & Sajovec

20100136557 - Methods and compositions for isolating nucleic acid sequence variants: The invention is drawn to isolating sequence variants of a genetic locus of interest using a modified iterative primer extension method. The nucleic acids analyzed are generally single stranded and have a reference sequence which is used as a basis for performing iterative single nucleotide extension reactions from a hybridized... Agent: Bozicevic, Field & Francis LLP

20100136548 - Methods and compositions for ordering restriction fragments: The invention relates to methods and systems for sequencing and constructing a high resolution physical map of a polynucleotide. In accordance with the invention, nucleotide sequences are determined at the ends of restriction fragments produced by a plurality of digestions with a plurality of combinations of restriction endonucleases so that... Agent: Knobbe Martens Olson & Bear LLP

20100136550 - Methods and compounds for the diagnosis of inflammatory disease and identification of pharmacological agents useful in the treatment of inflammatory disease: Methods for the diagnosis of inflammatory bowel diseases and the identification of agents useful in the treatment of such diseases based upon the agent's effect on reducing Pim-2 expression.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100136551 - Microfluidic platform and related methods and systems: A microfluidic platform comprising one or more chambers connectable through microfluidic channels, and comprising a substrate presenting aptamer sensors detectable through Raman active molecules, and related methods and systems.... Agent: Llnl/steinfl & Bruno John H. Lee, Assistant Laboratory Counsel

20100136523 - Molecular signature and assay for fluoroquinoline resistance in bacillus anthracis: The preferred therapeutic for human anthrax infections are therapeutics from the fluoroquinolone class, in particular, Ciprofloxacin (CIP). This invention discloses the molecular basis for fluoroquinolone (CEP in particular) action and provides the molecular signatures which form the basis of diagnostic assays. This invention further discloses nucleotide signatures associated with CIP-resistance... Agent: Quarles & Brady LLP

20100136536 - Molecular switches and methods for their use: The present invention relates to compositions and methods that allow the manipulation of the catalytic activity of multi-component nucleic acid complexes. Further, the invention provides methods which use these compositions and methods to create molecular sensors, molecular switches, and/or modulators or propagators of autocatalytic self-replicating cascades and other iterative processes.... Agent: Sullivan & Worcester LLP

20100136562 - Multivariate analysis involving genetic polymorphisms related to mediators of inflammatory response for prediction of outcome of critcally ill patients: A method of using genetic polymorphisms related to pro-inflammatory mediators to predict clinical outcome in critically ill patients admitted to an ICU is provided.... Agent: Kilyk & Bowersox, P.l.l.c.

20100136542 - Nucleic acid amplification and testing: Methods for amplifying a target nucleic acid by self-sustained amplification methods are described. The methods are designed, in particular, to be carried out without use of specialised lab facilities or instruments. Compositions, lyophilised formulations, and kits for carrying out the methods are also described.... Agent: Scully Scott Murphy & Presser, PC

20100136531 - Nucleic acid detection using lateral flow methods: Methods and kits for use in detecting a target nucleic acid in a sample are disclosed. In one particular application, the methods and kits allow for the detection of an undesirable micro-organism (e.g. Listeria, Salmonella or Enterobacteriaceae) in food or present on a food preparation surface.... Agent: 3m Innovative Properties Company

20100136537 - Photoreceptor precursor cells: The present invention relates to photoreceptor cells. In particular, the present invention provides photoreceptor cells comprising heterologous nucleic acid sequences and transgenic animals comprising the same. The present invention also provides photoreceptor precursor cells (e.g., rod photoreceptor precursor cells), and methods of identifying, characterizing, isolating and utilizing the same. Compositions... Agent: Casimir Jones, S.c.

20100136530 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 62 to 64 or a combination of at least two of... Agent: Fitzpatrick Cella Harper & Scinto

20100136553 - Prognosis prediction for melanoma cancer: The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as... Agent: Borson Law Group, PC

20100136547 - Pure mirna sample preparation method: The present teachings provide novel methods, compositions, and kits for analyzing mature micro RNAs (miRNAs). By taking advantage of the observation that most mature miRNAs in cells are tightly associated with RISCs, the present teachings provide approaches for studying mature miRNAs without the complications of additional nucleic acids. For example,... Agent: Life Technologies Corporation C/o Intellevate

20100136529 - Rare cell analysis using sample splitting and dna tags: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with... Agent: Fish & Richardson PC

20100136549 - Reproducible quantification of biomarker expression: A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.... Agent: Foley And Lardner LLP Suite 500

20100136570 - Sensitive and rapid determination of antimicrobial susceptibility: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20100136564 - Steroid responsive nucleic acid expression and prediction of disease activity: The invention relates to methods useful for diagnosing and monitoring the steroid responsiveness of a subject by detecting expression of steroid modulated genes and for predicting transplant rejection and non-rejection.... Agent: Morrison & Foerster LLP

20100136554 - Supported reagents, methods, and devices: Methods of providing at least one reagent for use in a device for processing sample material, delivering at least one reagent to a device for processing sample material, and adding at least one reagent to at least one of the steps in a process for detecting or assaying a nucleic... Agent: 3m Innovative Properties Company

20100136563 - System and method for nucleic acids containing fluid processing: A system and method for the processing of nucleic acids containing fluids involving manipulation of magnetically responsive particles contained therein are disclosed. In the system, a holder holds a plurality of containers containing the fluids, a heating device applies thermal energy to the fluids for incubation, and a separating device... Agent: Dinsmore & Shohl, LLP Fifth Third Center

20100136524 - Target protein and target gene in drug designing and screening method: The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases... Agent: Leydig Voit & Mayer, Ltd

20100136526 - Therapeutic agent for neuroblastoma targeting arid3b: It is intended to provide a therapeutic agent for neuroblastoma. More particularly, it is intended to provide the therapeutic agent for neuroblastoma containing an ARID3b inhibitor.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100136575 - B7-related nucleic acids and polypeptides useful for immunomodulation: The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated... Agent: Louis J. Wille Bristol-myers Squibb Company

20100136573 - Diagnosing neurodegenerative diseases: This document provides methods and materials related to determining whether or not a mammal (e.g., a human) has a neurodegenerative disease (e.g., frontotemporal dementia, AD, or amyotrophic lateral sclerosis (ALS)). For example, methods and materials for using the levels of TDP-43 polypeptides and/or TDP-43 polypeptide cleavage products (e.g., 25 kD... Agent: Fish & Richardson P.C.

20100136571 - I-plastin assay method for the in vitro diagnosis of colorectal cancer: A method for the in vitro diagnosis of colorectal cancer by determining the presence of the I-Plastin tumor marker in a biological sample taken from a patient suspected of having colorectal cancer. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis... Agent: Oliff & Berridge, PLC

20100136574 - Method for detecting a chronic inflammatory-associated disease: The present invention in one embodiment is an early detection marker for chronic or acute inflammatory-associated diseases. Chronic diseases may include atherosclerosis, Alzheimer's disease, asthma, rheumatoid arthritis, osteoarthritis, and inflammatory diseases of the bowel such as Crohn's disease, Ulcerative colitis, Irritable bowel syndrome and Inflammatory bowel disease. Acute diseases may... Agent: Dunlap Codding, P.C.

20100136572 - Method of assaying apolipoprotein ai for the in vitro diagnosis of colorectal cancer: The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Apolipoprotein AI tumor marker in a biological sample taken from a patient suspected of having colorectal cancer, it being understood that the assay is not turbidimetric. Said method can... Agent: Oliff & Berridge, PLC

20100136582 - Method for identification of somatic stem cells: The invention relates to a method for identification of somatic stem cells, wherein the spatial arrangement of epitopes in a sample is captured by MELC technology for identifying the phenotype specific to the somatic stem cells. The invention moreover relates to a composition, a kit and a biochip comprising at... Agent: Womble Carlyle Sandridge & Rice, PLLC

20100136583 - Method for diagnosing tumors by measuring the level of apolipoprotein a-iv: Method for diagnosing a tumor in an individual comprising the following steps: —measuring the amount of apolipoprotein A-IV (ApoA-IV) in a body fluid sample or tissue sample of an individual, —comparing the measured amount of ApoA-IV in said sample with a reference value, wherein the reference value is the ApoA-IV... Agent: Fulbright & Jaworski L.L.P.

20100136584 - Methods for using antibodies and analogs thereof: Camelid and shark single-domain heavy chain antibodies lacking the light chains, and their analogs are disclosed. Methods for using the antibodies and their analogs to detect antigens are disclosed. Methods to derivatize such antibodies and analogs to develop diagnostic assays are described. Also provided are kits, and methods of using... Agent: Foley And Lardner LLP Suite 500

20100136585 - Method and device for the determination of minor cell population in heterogeneous cell populations: The invention relates to a method for determining one or more cellularly bound analytes in a liquid sample, said method being carried out using a device comprising: at least one feeding zone (5) for applying the liquid sample; a porous membrane (2) that is suitable for letting cellular components penetrate... Agent: Foley & Lardner LLP

20100136586 - Method for the surveillance for biological, chemical and radiological agents: Provided is a method of surveillance for hazardous materials, e.g., chemical, biological and radiological agents. The method comprises assaying a sample derived from materials collected from a sample domain for the presence of a chemical, biological, or radiological agent. The sample domain comprises at least one collection point from which... Agent: Darby & Darby P.C.

20100136579 - Biomarkers useful in liver fibrosis diagnosis: Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and β-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100136577 - Compositions and methods for detection and treatment of proliferative abnormalities associated with overexpression of human transketolase like-1 gene: Methods for in vitro diagnosis of carcinoma are disclosed. In one aspect the invention relates to methods such as detecting the level of transketolase like-1 polypeptide, which are especially useful for the detection of tumors and their precursory stages based on the detection of overexpression of human transketolase like-1 gene... Agent: Patent Central LLC Stephan A. Pendorf

20100136576 - In vitro method for diagnosing prostate cancer: The invention relates to an in vitro method for diagnosing prostate cancer and to antibodies and fragments thereof directed against CK2-α and their use for the diagnosis and prognosis of prostate cancer.... Agent: Mcandrews Held & Malloy, Ltd

20100136578 - Method of measuring the activity of lipid-modified enzyme: It is intended to provide an assay method whereby the activity of a lipid-modifying enzyme can be conveniently measured over a wide range and a drug capable of controlling a lipid-modifying enzyme with the use of this assay method. The above problem can be solved by, for example, a method... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100136580 - Disheveled pdz modulators: The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators.... Agent: Genentech, Inc.

20100136581 - Diagnosis and treatment of malignant neoplasms: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100136587 - Method of identifying risk for thyroid disorder: A method for identifying a patient that is at risk for developing a thyroid disorder that occurs subsequent to treatment with a regimen that depletes lymphocytes, comprising determining whether antibodies directed against thyroid peroxidase or thyroid microsomes are present in the patient, wherein if the antibodies are present in the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100136588 - Methods and devices for diagnosis of appendicitis: A method is provided for determining the severity of appendicitis in a patient that includes testing a blood, serum or plasma sample from the patient for the quantity of MRP8/14 in the sample and comparing it with the quantity of MRP8/14 present in standard samples correlated with an appendicitis severity... Agent: Greenlee Winner And Sullivan P C

20100136589 - Methods and kits for determining von willebrand factor activity in the absence of ristocetin and for determining the activity of adamts-13 protease: Described herein are method(s), kit(s), reagent(s) and the like for determining von Willebrand factor (VWF) activity in a sample in the absence of ristocetin.... Agent: Dunlap Codding, P.C.

20100136590 - Method of determining nt-probnp: The invention relates to a method of determining equine NT-proBNP, or fragments thereof, comprising the steps of: providing an equine sample, contacting the sample with at least one antibody which specifically binds to equine NT-proBNP, and determining the presence and/or concentration of the equine NT-proBNP or fragments thereof existing in... Agent: Fulbright & Jaworski L.L.P.

20100136591 - Method of measuring lipid in specific lipoprotein: A method of measuring a lipid in a specific lipoprotein characterized by using a polycyclic polyoxyalkylene derivative at least in the step of determining the specificity of the measurement of the target lipid.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100136593 - Method for diagnosing and distinguishing stroke and diagnostic devices for use therein: A method for determining whether a subject has had a stroke and, if so, the type of stroke which includes analyzing the subject's body fluid for at least four selected markers of stroke, namely, myelin basic protein, S100 protein, neuronal specific enolase and a brain endothelial membrane protein such as... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100136592 - Photo-induced damage mitigating agents and preparation and methods of use thereof: Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photo-induced damage mitigating agents to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced... Agent: Pacific Biosciences Of California, Inc.

20100136594 - High-throughput assay for evaluating dipeptidyl peptidase i activity: A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding... Agent: Patton Boggs LLP

20100136595 - Hydrocarbon-forming oxidative decarbonylase enzyme, hydrocarbons produced thereby, and method of use: The present disclosure relates to oxidative decarbonylase enzymes, methods of making hydrocarbons with such enzymes, hydrocarbons produced therefrom and uses thereof. More particularly, the present disclosure relates to isolated polypeptide sequences that are cytochrome P450 enzymes with oxidative decarbonylase activity and methods of their use to generate hydrocarbon products, such... Agent: Klarquist Sparkman, LLP

20100136603 - kit and a method for evaluating toxicity using spore release by the green alga ulva: The present invention relates to a kit and a method for evaluating toxicity of a waterbody sample by a spore release of a green alga Ulva. The kit for evaluating the toxicity of a waterbody sample comprises a capsule-type bioware that includes the leaf of the green alga Ulva prepared... Agent: Ampacc Law Group

20100136596 - Device for receiving, treating, and storing small volume samples: A device is provided by means of which biomolecules in samples in a volume range from <1 μl to 500 μl can be received, treated and stored in a quick, reproducible and loss-free manner as easily, effortlessly and practically as possible, and without any risk of damaging the device. The... Agent: Jordan And Hamburg LLP

20100136601 - Glass-cell vial for examining slight amount of specimen: A vial is provided which comprises function of cell capable of optical examination, and the inner surface of bottom of the vial is formed to be a round-state convex part upwardly and the outer surface of the bottom is formed to be in convex state. When a small amount of... Agent: Kratz, Quintos & Hanson, LLP

20100136604 - In vitro tumor angiogenesis model: Provided is a method of inducing tubulogenesis in normal endothelial cells comprising co-culturing the normal endothelial cells with tumor cells and forming tubules from the normal endothelial cells.... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100136597 - Method for modularting activity of t lymphocytes: The invention relates to methods and compositions which modulate T lymphocyte activity. It has been found that two, T lymphocyte receptors, especially TCR and CD8, are present at a distance from each other on T lymphocyte surfaces. Via use of modulators which change the distance between these receptors, the activity... Agent: Fulbright & Jaworski, LLP

20100136606 - Method of measuring physical property values of cell and physical property measuring apparatus: Firstly, a shape of a cell as an object of a measurement is modeled, and a complex electric permittivity response when an AC electric field is applied to the cell is obtained through a numerical analysis (Step S1). A numerical calculation is carried out based on that result while values... Agent: Wolf Greenfield & Sacks, P.C.

20100136599 - Methods and products related to the improved analysis of carbohydrates: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the... Agent: Choate, Hall & Stewart LLP

20100136598 - Novel mesenchymal progenitor cells derived from human blastocyst-derived stem cells: Described herein is a mesenchymal human progenitor (hBS-MP) cell population derived from human blastocyst-derived stem (hBS) cells and a method to obtain the progenitor cell population in which is eliminated the need of co-culture steps, cell sorting, manual selection, and transfections. Also, the use of the hBS-MP cells in drug... Agent: Buchanan, Ingersoll & Rooney PC

20100136602 - Sour taste receptor compositions and methods: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste... Agent: Casimir Jones, S.c.

20100136605 - System for and method of positioning cells and determining cellular activity thereof: A device for positioning at least one cell in at least one addressable position, the device comprising a substrate formed with at least one addressable pore and at least one channel embedded in the substrate and being in fluid communication with the at least one pore. The at least one... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100136600 - Urine based detection of a disease state caused by a pneumococcal infection: There is provided a method of diagnosing a disease state in a subject. The disease state is caused or effected by pneumococcal infection. The method includes obtaining a biological test sample from the subject. The biological sample includes at least one metabolite selected from the group consisting of citrate, trigonelline,... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20100136609 - Method for separation, characterization and/or identification of microorganisms using raman spectroscopy: The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be... Agent: Biomerieux, Inc.

20100136610 - Methods and microfluidic devices for single cell detection of escherichia coli: The present invention features a microfluidic device for detecting Escherichia coli. The device comprises (a) a base slide having a first inlet and a second inlet, both of which connect at a vertex, where the first inlet is for accepting beads conjugated with anti-E. coli and the second inlet is... Agent: Nguyen & Tarbet

20100136608 - Multiple filter array assay: The present invention relates to a method and device for the assay and determination of the concentration of organisms or other filterable constituents of a fluid test sample. The method includes the steps of exposing, processing, and analyzing a liquefied sample in a filter tray apparatus. Each filter element (FE)... Agent: Morgan Lewis & Bockius LLP

20100136607 - Sensor device: The invention relates to a sensor device for detecting CO2 wherein the said device has (a) a support base, (b) an acid-base indicator composition that stably changes colour upon exposure to CO2; and (c) a viewer cover, and wherein least (a) and (c) is CO2 permeable and wherein (b) includes... Agent: Merchant & Gould PC

20100136611 - Method of detecting bacterial contamination using dynamic light scattering: Methods of detecting bacterial contamination in a platelet concentrate are performed using a dynamic light scattering (DLS) instrument and a sample holder. A sample of platelet concentrate can be held vertically or horizontally in a capillary in the sample holder. Alternatively, novel platelet storage bags modified to include an optically... Agent: Cantor Colburn, LLP

20100136612 - Horizontal antigen retrieval: The present invention relates to a method for enhancing immunoreactivity of a tissue or cell sample fixed in a fixing medium, a target retrieval composition and its use. The method comprises providing a carrier in a horizontal position, said carrier having thereon a tissue or cell sample, said tissue or... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100136613 - Pressure-assisted molecular recovery (pamr) of biomolecules, pressure-assisted antigen retrieval (paar), and pressure-assisted tissue histology (path): A method is disclosed for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. The method involves placing the fixed tissue in a liquid under elevated temperature and pressure conditions that are sufficient to reverse the fixation-induced cross-linking, restore antigenicity to proteins, and permit improved molecular... Agent: Klarquist Sparkman, LLP

20100136614 - Dendrimer-like modular delivery vector: Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. The nucleic acids are used to form dendrimers that are useful as supports, vectors, carriers or delivery vehicles for a variety of compounds in... Agent: Wilson, Sonsini, Goodrich & Rosati

20100136615 - Method of producing soybean protein material: It is intended to provide a soybean protein material which is highly dispersible in hot water and highly miscible with water so as to give a solution showing regulated coarseness. More specifically, it is intended to provide a soybean protein material which is appropriately usable in preparing protein drinks. According... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100136619 - Expression system: A protein expression system is provided. The system comprises: a) a T7 RNA polymerase-dependent promoter operably linked to an expression cassette for a protein of interest; and b) an expression cassette for T7 RNA polymerase operably linked to a λpL promoter and at least two perfect palindrome operator sequences.... Agent: Morgan Lewis & Bockius LLP

20100136617 - Halohydrin epoxidase: The present invention provides an industrially useful improved halohydrin epoxidase, a method for producing the same, and a method for producing an epihalohydrin or 4-halo-3-hydroxybutyronitrile using the same. The improved halohydrin epoxidase of the present invention consists of an amino acid sequence in which a specific amino acid substitution mutation... Agent: Darby & Darby P.C.

20100136618 - Method for producing cellulase and hemicellulase having high hydrolytic activity: The present invention provides a novel cellulase-producing fungus, i.e. Acremonium cellulolyticus CF-2612 strain or a mutant thereof, which has an ability to produce cellulase so highly, a method for producing cellulase and/or hemicellulase by culturing said fungus, and a method for degrading or saccharifying biomass using the cellulase and/or hemicellulase.... Agent: Foley And Lardner LLP Suite 500

20100136622 - Method for the production of proteins: The present invention relates to a process for the purification of a protease.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20100136623 - Mutations in ion channels: A method of identifying a subject predisposed to a disorder associated with ion channel dysfunction, comprising ascertaining whether at least one of the genes encoding ion channel subunits in said subject has undergone a mutation event such that a cDNA derived from said subject has the sequence set forth in... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20100136616 - Selection of host cells expressing protein at high levels: The invention provides a DNA molecule comprising a multicistronic transcription unit coding for i) a polypeptide of interest, and for ii) a selectable marker polypeptide functional in a eukaryotic host cell, wherein the polypeptide of interest has a translation initiation sequence separate from that of the selectable marker polypeptide, and... Agent: Traskbritt, P.C.

20100136621 - Solubility tags for the expression and purification of bioactive peptides: Peptide tags, referred to here as inclusion body tags, are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100136620 - Soluble, stable form of hdm2, crystalline forms thereof and methods of use thereof: The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods... Agent: Merck Patent Department (k-6-1, 1990)

20100136627 - Engineered rabbit antibody variable domains and uses thereof: The present invention relates to methods for screening and producing polypeptides that immunospecifically bind to an antigen, which: polypeptides comprise binding domains that are derived from rabbit immunoglobulin. Using rabbit antibody heavy-chain or light-chain scaffolds, the methods of the invention allow identification of novel CDR loops and framework regions that... Agent: King & Spalding

20100136624 - Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method: A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind.... Agent: Genentech, Inc.

20100136625 - Method for the high level expression of active lymphotoxin-beta receptor immunoglobulin chimeric proteins and their purification: Methods for high level expression of active lymphotoxin-β receptor immunoglobulin chimeric proteins and their purification.... Agent: Lahive & Cockfield, LLP / Biogen Idec Floor 30, Suite 3000

20100136626 - Production and use of novel peptide-based agents for use with bi-specific antibodies: The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a targetable conjugate. The targetable conjugate encompasses a hapten to which antibodies have been prepared. In preferred... Agent: Immunomedics, Inc.

20100136628 - Novel ox40r binding agents: The present invention discloses peptides isolated from the extracellular domain of OX40 Ligand (OX40L) capable of binding OX40 Receptor (OX40R) and inhibiting OX40R-OX40L interaction. Such peptides, fusion proteins comprising them, as well as peptides and other molecules designed on their sequences, can be used as OX40R binding agents competing with... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100136629 - Enhanced ethanol fermentation using biodigestate: Methods and systems for enhancing ethanol production using a suspending fluid are described. The suspending fluid includes organic material that has at least partially been anaerobically digested and anaerobic microorganisms, and is substantially free of non-anaerobic microorganisms. Also described are methods and systems for hydrolyzing a feedstock for fermentation that... Agent: Mccarter & English, LLP Boston

20100136630 - Production of low molecular weight hyaluronic acid: t

20100136632 - Fully automated portable dna detection system: Provided herein is a portable thermocycler, comprising: (i) a case; (ii) a rotary plate in the case; (iii) a plurality of heating blocks arranged in a geometric pattern disposed on the rotary plate; and (iv) at least one vessel adapted to move and contact at least two of the plurality... Agent: Foley And Lardner LLP Suite 500

20100136631 - Improved primers and probes for the amplification and detection of hiv gag,rev and nef: The invention relates to improved methods and compositions for the nucleic acid amplification of one or multiple variants (strains) of Human Immunodeficiency Virus (HIV) present in a sample, and preferably in a sample from a pathogen infected individual. In particular, novel primers, methods and kits for the amplification of one... Agent: Elaine T. Sale,

20100136633 - Compositions and methods for the assembly of polynucleotides: The present invention provides compositions and methods for rapid assembly of one or more assembled polynucleotides from a plurality of component polynucleotides. The methods of the invention utilize circular nucleic acid vectors that comprise a DNA segment D flanked by an annealable linker sequence, annealable linker sequence pairs LA and... Agent: Jones Day

20100136634 - Method and equipment for production of glucose, ethanol,furfural,furane and lignin from renewable raw materials: Method and equipment for production of fermentable saccharides, ethanol, furfural, furane, lignin, acetic acid and formic acid from lignocellulosic and amylaceous materials. The method comprises one-stage or two-stage continuous thermo-compressive hydrolysis of ligno-cellulosic particles, cellulase treatment of unreacted lignocellulose, amylase treatment of formed monosaccharides combined with added amylaceous materials, and... Agent: Dykema Gossett PLLC

20100136635 - Method of inducing chirality to epoxides using 2,3:4,6 di-o-isopropylidene-2-keto-l-gulonic acid monohydrate: The present invention relates to a recyclable method to prepare chirally pure epoxides directly from olefins using a novel chiral acid 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid monohydrate as chiral inducer and anhydrous hydrogen peroxide in the form of urea hydrogen peroxide adduct (UHP) as oxidant and lipase enzyme as catalyst. Under the influence... Agent: Fulbright & Jaworski L.L.P.

20100136636 - Process for selective production of theaflavin: The present invention provides a method for selective production of theaflavin in large amounts at high yield, and in an easy and inexpensive manner. Specifically, it relates to a method for selective production of theaflavin whereby a processed plant extract containing epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate is combined with a... Agent: Frishauf, Holtz, Goodman & Chick, PC

20100136638 - Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase: Methods of using beta-alanine/pyruvate aminotransferase to produce 3-hydroxypropionic acid and derivatives thereof, from beta-alanine, are disclosed. Cells and recombinant nucleic acids that can be used to practice the methods are also disclosed.... Agent: Klarquist Sparkman, LLP

20100136637 - Recombinant microorganism having a producing ability of polylactate or its copolymers and method for preparing polyactate or its copolymers using the same: t

20100136639 - Production of peracids using an enzyme having perhydrolysis activity: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20100136640 - Enhanced butanol producing microorganisms and method for preparing butanol using the same: The present invention relates to a recombinant mutant microorganism having enhanced butanol producing capacity and a method for producing butanol using the same. In the microorganism, genes coding for enzymes responsible for the biosynthesis of lactate, ethanol and/or acetate are deleted or attenuated and genes coding for enzymes involved in... Agent: Moore & Van Allen PLLC

20100136641 - Strain for butanol production with increased membrane unsaturated trans fatty acids: Bacteria that are not natural butanol producers were found to have increased tolerance to butanol when the membrane content of unsaturated trans fatty acids was increased. Feeding cells with unsaturated trans fatty acids increased their concentration in the membrane, which may also be accomplished by expressing a fatty acid cistrans... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100136642 - Recovery of lignin and water soluble sugars from plant materials: In one aspect, a process for treating woody plant material is provided, the process involving contacting the plant material with a continuous flow of an aqueous ethanol solution at elevated temperature and pressure under conditions that promote extraction of ethanol-soluble lignin from the plant material and retention of hemicellulose sugars,... Agent: Speckman Law Group PLLC

20100136643 - Method and apparatus for producing hydrogen and microorganism-immobilization pellets used in the same: The hydrogen-producing method of the an aspect of the present invention is a method for producing hydrogen in which hydrogen is produced from an organic matter using a microorganism, characterized by using pellets on which hydrogen-producing acid-resistant bacteria are entrapped and immobilized, producing hydrogen by bringing the pellets into contact... Agent: Birch Stewart Kolasch & Birch

20100136645 - Method for preparing a cell-derived extracellular matrix scaffold: The present invention relates to a method for fabricating a cell-derived extracellular matrix scaffold, more particularly, to a method for fabricating a cell-derived extracellular matrix scaffold, the method comprising the steps of obtaining a chondrocyte/extracellular matrix (ECM) membrane from chondrocytes derived from animal cartilage, obtaining a pellet-type scaffold-free construct by... Agent: Lucas & Mercanti, LLP

20100136644 - Methods for improving the cultivation of aquatic organisms: The present invention relates to electrochemical methods for altering a biological characteristic of an aquatic organism such as an algae or bacterium. The invention includes alterations to biological characteristics such as growth rate, membrane permeability and buoyancy.... Agent: Knobbe Martens Olson & Bear LLP

20100136646 - Selective inactivation of microorganisms with a femtosecond laser: A method is provided for selectively inactivating microorganisms with femtosecond pulsed lasers. Under proper laser conditions, irradiation of the femtosecond pulsed laser causes inactivation of pathogenic microorganisms, for example, viruses, bacteria and protozoa, without causing cytotoxicity in mammalian cells. Pathogenic microorganism activity is diminished through an impulsive stimulated Raman scattering... Agent: Ashok Tankha

20100136647 - Method for production of cell attachment and culture surfaces: The present invention relates to the field of adherent cell culture. More closely, the invention relates to a method for production of a cell attachment and culture surface, such as a microcarrier, comprising a guanidino-containing ligand, wherein the ligand is coupled via reaction involving a primary amine to the surface... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100136648 - Expansion moulding of shape memory polymers: The present invention relates to shape memory materials and to a method for controlling shape change in shape memory materials. In particular, the invention relates to a method and a system for forming complex shapes from shape memory materials and to shape memory materials having complex shapes.... Agent: Norman F. Hainer, Jr. Smith & Nephew, Inc.

20100136649 - Encapsulation of cells in biologic compatible scaffolds by coacervation of charged polymers: This invention relates to a method for the encapsulation of cells in biologic compatible three dimensional scaffolds and the use of such cells encapsulated in a scaffold. The cells are embedded in a charged polymer that is complex coacervating with an oppositely charged polymer within biologic compatible scaffolds. The polymer... Agent: Stout, Uxa, Buyan & Mullins LLP

20100136650 - Mechanism-based inactivators of autotaxin: A novel class of compounds to inactivate autotaxin enzymes is provided. Such compounds include mono- and di-fluoromethylphenyl C12-C18 phosphodiesters and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds are non-cytotoxic, and can... Agent: Wyatt, Tarrant & Combs, LLP

20100136651 - Detection, isolation and uses of renalase (monoamine oxidase c): The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100136652 - Molecular conjugate: A method is disclosed for making a conjugate of two molecules using a hydrazide thiol linker. In a particular working embodiment, an Fc-specific antibody-enzyme conjugate is made using the method and demonstrated to provide exceptional staining sensitivity and specificity in immunohistochemical and in situ hybridization assays.... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20100136653 - Creation of diversity in polypeptides: The inventors developed a method to identify and alleviate such steric hindrance in the resulting polypeptides. In an alignment of the three-dimensional structures, steric hindrance is indicated when residues from two different structures are located within a certain distance. Pairs of residues at corresponding positions in the amino acid sequences... Agent: Novozymes North America, Inc.

20100136654 - Method for transcription-degradation dual regulation for protein by antibiotic: The present invention provides an expression vector, containing expressibly (a) a polynucleotide encoding a fusion protein of a mutant of a repressor protein, which binds to an antibiotic, and a target protein, and (b) a polynucleotide encoding a protein controlling the transcription of the polynucleotide in (a), the transcription of... Agent: Morgan Lewis & Bockius LLP

20100136655 - Fungal alpha-amylase variants: The inventors have developed a method of altering the amino acid sequence of a fungal alpha-amylase to obtain variants, and they have used the method to construct such variants. The variants may be useful for anti-staling in baked products. Accordingly, the invention provides a method of constructing fungal alpha-amylase variants... Agent: Novozymes North America, Inc.

20100136656 - Immobilized microbial nitrilase for production of glycolic acid: The present invention is directed to a process for improving the specific activity of a dehydrated enzyme catalyst having nitrilase activity for hydrolysis of glycolonitrile to glycolic acid upon rehydration. In particular, a process is provided comprising pretreating an enzyme catalyst having nitrilase activity with glutaraldehyde, immobilizing the gutaraldehyde-preteated enzyme... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20100136658 - Generation of oncolytic adenoviruses and uses thereof: The present invention relates to a method for the production of onolytic adenoviruses having increased potency and their therapeutic applications for cancer. Recombinant adenoviruses and methods to produce them are provided.... Agent: Banner & Witcoff, Ltd.

20100136659 - Infectious cdna clone of north american porcine reproductive and respiratory syndrome (pprs) virus and uses thereof: The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American... Agent: Pfizer Inc Mary J Hosley

20100136657 - Method for storing silica-based material, package produced with the method and use of package for packaging of silica-based products: A method for storing a water-soluble undissolved silica-based material, optionally with an incorporated functional agent. The method includes immersing the material in an aqueous liquid phase which is initially saturated with a water-soluble silica-based material which is the same or different than the undissolved silica-based material, such that the undissolved... Agent: James C. Lydon

20100136660 - Methods for producing members of specific binding pairs: A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding... Agent: Howrey LLP - East

20100136663 - preparation of an artificial transcription factor comprising zinc finger protein and transcription factor of prokaryote, and a use thereof: The present invention relates to an artificial transcription factor which can artificially regulate gene expression of an E. coli, wherein the transcription factor comprising zinc finger proteins and transcription factors of prokaryote, and to be engineered E. coli using the same. Specifically, the artificial transcription factors in E. coli as... Agent: Morrison & Foerster LLP

20100136661 - Systems and methods for producing biofuels and related materials: Clostridium phytofermentans cells (American Type Culture Collection 700394T) and all other strains of the species can ferment materials such as biomass into useful products and coproducts, such as ethanol, hydrogen and organic acids. Compositions that include Clostridium phytofermentans are also disclosed.... Agent: Milstein Zhang & Wu LLC

20100136662 - Endotoxin binding by lactic acid bacteria and bifidobacteria: The invention relates to the use of at least one strain of lactic acid bacteria and/or bifidobacteria having hydrophobic surface properties, for the preparation of a composition intended for the prevention or the treatment of endotoxin mediated and/or associated disorders and human or pet food compositions prepared thereof... Agent: K&l Gates LLP

20100136664 - Carboxin resistance gene for flammulina velutipes: The present invention pertains to a polynucleotide sequence expressed in Flammulina velutipes against carboxin and the proteins encoded thereby. Also provided is the expression vector and host cell comprising the polynucleotides of the invention.... Agent: Wpat, PC Intellectual Property Attorneys

20100136666 - Garbage disposal system and maintenance schedule creating method of garbage disposal system: A technique of making a maintenance program concerning a garbage disposal system by analyzing at least the weight of garbage brought in by users at least for one week while disposing of the garbage. Before garbage to be disposed of is inputted, the identification information on the user and the... Agent: Dla Piper LLP Us

20100136665 - System and process for reutilization of used disposable diapers: The invention provides a system and a process for reutilization of used paper diapers which enable effective utilization of used paper diapers through processing and can contribute to CO2 discharge reduction more flexibly as compared with the disposal thereof without processing. A reutilization system (1) provided with a processing apparatus... Agent: Sughrue Mion, PLLC

20100136667 - Thermal tolerant avicelase from acidothermus cellulolyticus: The invention provides a thermal tolerant (thermostable) cellulase, AviIII, that is a member of the glycoside hydrolase (GH) family. AviIII was isolated and characterized from Acidothermus cellulolyticus, and, like many cellulases, the disclosed polypeptide and/or its derivatives may be useful for the conversion of biomass into biofuels and chemicals.... Agent: Paul J White, Patent Counsel National Renewable Energy Laboratory (nrel)

20100136668 - Systems and methods for isolating and using clinically safe adipose derived regenerative cells: Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating... Agent: Knobbe Martens Olson & Bear LLP

20100136669 - Microchip with accessible front side: The invention relates to a microchip assembly (40) that is particularly suited for biosensor applications in which a sensitive front side (13) of the associated microchip (10) has to be brought close to a sample. The microchip (10) comprises grooves or recesses on the front side of its substrate in... Agent: Philips Intellectual Property & Standards

20100136670 - Sampling method and device: A test device configured for obtaining a sample from within a tube such as the one or more channels of an endoscope. The device can include an elongate sample probe and light blocking material.... Agent: Charm Sciences, Inc.

20100136671 - Incubation container: A laboratory dish comprises an incubation container, containing cultured cells, for observation through a microscope, in which a partitioning member partitions an interior of the incubation container into a plurality of incubation chambers by substantially perpendicular walls. The partitioning member tightly fits to a bottom portion of the incubation container,... Agent: Miles & Stockbridge PC

20100136672 - Cell culture tube and multiple roller tube cell culture apparatus including the same: Disclosed is a cell culture tube, having in opposite end walls two respective eccentric openings which communicate with each other through an inner straight passage formed in the cell culture tube, in which the inner straight passage is tilted at an angle relative to a longitudinal axis of the cell... Agent: Clark & Elbing LLP

20100136673 - Cell/tissue culturing device, system and method: A device, system and method for axenically culturing and harvesting cells and/or tissues, including bioreactors and fermentors. The device is preferably disposable but nevertheless may be used continuously for a plurality of consecutive culturing/harvesting cycles prior to disposal of same. This invention also relates to batteries of such devices which... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100136674 - Plant for producing an oxygen-containing additive as an ecologically beneficial component for liquid motor fuels: A plant for producing an oxygen-containing additive for liquid motor fuels comprises an anaerobic fermentation vessel, a gasholder, a system for removal of sulphuretted hydrogen, and a hotwell. The plant further comprises an aerobic fermentation vessel, a device for liquid substance pumping, a device for liquid aeration with an oxygen-containing... Agent: United States Department Of Energy

20100136675 - Incubation and dry storage apparatus: An incubation and dry storage apparatus, especially for samples made of organic material, is provided.... Agent: Baker & Hostetler LLP

20100136676 - Modular continuous production of micro-organisms: Process for the growing of micro-organism in an open and continuous system further being characterized by means for creating within said system a habitat in which natural, diverse and heterogeneous emicrobial communities can autonomously react and adapt to a changing environment... Agent: Darby & Darby P.C.

20100136677 - Apheresis tubing set: An apheresis tubing set comprises a cryocyte bag for collecting cells separated during apheresis. The cryocyte bag may comprise a mixing compartment in fluid communication with a cell storage compartment, wherein the mixing compartment comprises a cryoprotectant port and a cell sample port and wherein the storage and mixing compartments... Agent: K&l Gates LLP

20100136678 - Methods of diagnosis of spinal muscular atrophy and treatments thereof: Methods for treating SMA in a subject comprise administering to the subject a recombinant genetic vector comprising at least one copy of a Stathmin inhibitor. The inhibitor can be a Stathmin expression inhibitor. The inhibitor can be or can encode an antisense or RNAi nucleic acid, such as a siRNA... Agent: Harness, Dickey & Pierce, P.L.C

20100136679 - Apparatus and method for processing biological material: The application discloses an apparatus and method for processing biological material, including a suspension of cells.... Agent: Baxter Healthcare Corporation

20100136680 - Baglike container for centrifugation and method of gene transfer using the same: Baglike container (1) that is fitted in a centrifuge to thereby allow centrifugation of any dispersion liquid placed therein. The baglike container for centrifugation is one comprising a main frame constituted of first container wall (3) with recess portion (6) formed so as to allow fitting in a centrifuge and... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100136681 - Cellular compositions for the treatment of kidney disease and uses thereof: As described in more detail below, the present invention provides cellular compositions for the treatment or prevention of kidney disease. The invention is based, at least in part, on the discovery of a population of cortical peritubular Flk1- and Seal-expressing kidney cells having a high tubulogenic potential.... Agent: Edwards Angell Palmer & Dodge LLP

20100136682 - Polyvalent rna-nanoparticle compositions: The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity.... Agent: Marshall, Gerstein & Borun LLP

20100136683 - Methods for isolating cells based on product secretion: The invention provides methods for purifying one or more cells based on the level of one or more products secreted by the cells. In one embodiment, the method involves (a) contacting a plurality of cells immobilized in proximity to a capture matrix, the capture matrix capable of localizing a product... Agent: Knobbe Martens Olson & Bear LLP

20100136684 - Natural igm antibodies: The invention provides natural IgM antibodies that may be used to induce inflammatory diseases or disorders such as ischemia-reperfusion injury to create animal models of such inflammatory diseases or disorders.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20100136685 - Method for transferring cells to carriers and application thereof: The invention provides a method for transferring cells to carriers, including: (a) providing a hydrophobic cell culture container or a cell culture container coated with a hydrophobic material on a bottom thereof; (b) adding carriers which are more hydrophilic than the hydrophobic cell culture container or hydrophobic materials and a... Agent: Quintero Law Office, PC

20100136686 - Apparatus and method for culturing and preserving tissue constructs: A disclosure is made of various apparatus and methods for culturing and preserving cells and tissue in ways that minimize contamination potential, direct cells to reside in desired areas, allow uniform cell distribution during seeding, provide optimal growth conditions by controlling the amount of medium residing in proximity of cells,... Agent: Patterson Thuente Christensen Pedersen, P.A.

20100136687 - Methods for enhanced propagation of cells: The present invention relates generally to methods for the isolation and propagation of cells. For example, embodiments of the present invention relate to isolation and propagation methods for the manufacture of a large number of cells for use, for example, in biotherapeutic devices, such as devices for renal replacement therapy... Agent: Goodwin Procter LLP Patent Administrator

20100136688 - Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells: The invention relates to methods for differentiating progenitor cells into insulin producing pancreatic islet cells and compositions and methods for using such cells.... Agent: Foley And Lardner LLP Suite 500

20100136689 - Method for decomposing biological tissue: A biological tissue is decomposed in a short time, and cells are obtained at a high yield without interfering with the health of the cells obtained through the decomposition. There is provided a method for decomposing biological tissue which decomposes a biological tissue under an action of a digestive enzyme,... Agent: Scully Scott Murphy & Presser, PC

20100136690 - Slicing device: The invention relates to a biological microglia comprising at least two pores having a size adopted to allow cells, cell aggregates, tissue or other biological material to pass through said pores, and one or several slicing beams separating said pores from each other, wherein biological material is split/sliced/cleaved into at... Agent: Merchant & Gould PC

20100136691 - Process for the production of a structure comprising crystalline cellulose: In a process for the production of a structure comprising crystalline cellulose (10), cellulose (10) -forming organisms are at least partly cultured in a hollow mould (5). The hollow mould (5) is produced by means of a 3D printer (1), which builds up at least a part (2a, 2b) of... Agent: Marjama Muldoon Blasiak & Sullivan LLP

20100136692 - Plasmids and phages for homologous recombination and methods of use: Lambda phages that can be used to introduce recombineering functions into host cells are disclosed. Also disclosed are plasmids that can be used to confer recombineering functions to a variety of strains of E. coli and to other bacteria, including Salmonella, Pseudomonas, Cyanobacteria, Spirochaetes. These plasmids and phages can be... Agent: Klarquist Sparkman, LLP

20100136693 - Mutants of deoxycytidine kinase having extended enzymatic activity: The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein Y, X and Y both belonging to the same class of enzyme commission (EC) nomenclature or belonging... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100136694 - Cone-shaped adapter for a gene gun: A cone-shaped adapter for attachment to a muzzle of a gene gun is generally provided. The cone-shaped adapter comprises sidewalls that taper from a base plane at one end and to an apex aperture at an opposite end and a fitting. The sidewalls form a base angle of from about... Agent: Dority & Manning, P.A.

20100136695 - Double-stranded oligonucleotides: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the... Agent: Life Technologies Corporation C/o Intellevate

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