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Chemistry: molecular biology and microbiology May archived by USPTO category 05/10Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 05/27/2010 > patent applications in patent subcategories. archived by USPTO category
20100129784 - Perfusion device for hollow organs, and the use thereof for the perfusion of an explanted hollow organ: A perfusion liquid is suctioned from a perfusion liquid reservoir (16) through the automatic two-way valve (4) by drawing a syringe (5) serving as the perfusion liquid displacement device. For this purpose, the connection from the syringe (5) to the cannula (14) is closed by the two-way valve (4). The... Agent: Collard & Roe, P.C.
20100129785 - Agents and methods for spectrometric analysis: Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or... Agent: Patent Docket Department Armstrong Teasdale LLP
20100129786 - Agents and methods for spectrometric analysis: Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or... Agent: Patent Docket Department Armstrong Teasdale LLP
20100129787 - Agents and methods for spectrometric analysis: Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or... Agent: Patent Docket Department Armstrong Teasdale LLP
20100129789 - Automated assay and system: An automated assay processing method including transferring a first number of samples from respective sample containers to a first intermediary vessel, determining the testing adequacy of a second number of samples in a second intermediary vessel, preparing a third number of samples in a third intermediary vessel for downstream testing;... Agent: Hunton & Williams LLP Qiagen Gaithersburg Inc.
20100129788 - Method for evaluating the response of an individual to a treatment with a type i interferon (ifn): A method for evaluating the in vivo presence of a factor that prevents the biological effect of a type I (IFN) in an individual that is under treatment with type I interferon is described. The in vivo presence of antibodies directed against a type I interferon (IFN) is evaluated in... Agent: Knobbe Martens Olson & Bear LLP
20100129795 - Agents and methods for spectrometric analysis: Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or... Agent: Patent Docket Department Armstrong Teasdale LLP
20100129821 - Broad range pcr-based compositions and methods for the detection and identification of fungal pathogens: Disclosed herein are methods for detecting a fungal pathogen in a patient sample, involving isolating the sample, carrying out a PCR reaction on the sample to generate an amplicon that includes a region of the fungal 28S ribosomal RNA gene, and detecting the PCR amplicon. Also disclosed are sequences of... Agent: Schwabe, Williamson & Wyatt, P.C.
20100129799 - Cancer susceptibility variants on chr8q24.21: A region on chromosome 8q24.21 has been demonstrated to play a major role in particular forms of cancer. It has been discovered that certain markers and haplotypes are indicative of a susceptibility to particular cancers, including prostate cancer. Diagnostic applications for identifying a susceptibility to cancer using these markers and... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20100129791 - Cdna encoding a gene bog (b5t over-expressed gene) and its protein product: Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-β1 as well as in primary liver tumors.... Agent: Nih-ott
20100129793 - Composite particles: Composite particles and methods of synthesizing a composite particle are disclosed, in particular, methods of synthesizing a composite particle comprising a dielectric component, a magnetic component, and a gold shell are disclosed. Further disclosed herein are methods of detecting a target compound using the composite particles of the present invention.... Agent: Marshall, Gerstein & Borun LLP
20100129813 - Compositions and methods for detecting food-borne pathogens: The present invention provides formulations and methods for isolating food-borne pathogens from a great variety of food matrices. Methods for isolating microorganisms from clinical and environmental specimens are also disclosed. The invention also concerns methods for rapid and efficient isolation of sufficiently pure DNA from small amounts of various pathogenic... Agent: Mcdermott, Will & Emery LLP Attn:IPDepartment
20100129822 - Compositions and methods for detecting small rnas, and uses thereof: Compositions and methods are provided for the detection of small RNA target nucleic acids, preferably miRNA target nucleic acids, wherein the compositions and methods provide for sensitive and specific detection of the target nucleic acids. The compositions and methods include using one or more of a first amplification oligomer that... Agent: Gen Probe Incorporated
20100129811 - Compositions for use in identification of pseudomonas aeruginosa: The present invention relates generally to identification of Pseudomonas aeruginosa bacteria or strains of Pseudomonas aeruginosa, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.... Agent: Abbott Laboratories C/o Polsinelli Shughart PC
20100129798 - Detecting genetic predisposition to osteoarthritis associated conditions: This application relates to methods and kits for detecting predisposition to increased risk for osteoarthritis associated conditions.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100129792 - Direct monitoring and pcr amplification of the dosage and dosage difference between target genetic regions: Disclosed herein are methods of detecting target nucleic acids. In particular, methods for anti-primer quenching real-time PCR (aQRT-PCR) are described. The methods provide for detection of target nucleic acids in simplex or multiplex formats for gene copy number determination and SNP-genotyping. Also described are methods for determining the dosage difference... Agent: Foley & Lardner LLP
20100129824 - Distinguishing pca3 messenger rna species in benign and malignant prostate tissues: This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer... Agent: Goudreau Gage Dubuc
20100129826 - Double stranded rna receptor (dsrna-r) and methods relating thereto: The present invention is directed to nucleic acid molecules and polypeptides encoding a dsRNA receptor (dsRNA-R). The dsRNA-R contains a THD, interacts with the MyD88 adapter protein, and may bind to dsRNA. The present invention is also directed to antibodies against dsRNA-R and to methods of modulating an immune response... Agent: Novartis Vaccines And Diagnostics Inc.
20100129796 - Dye probe fluorescence resonance energy transfer genotyping: An improved method for detecting, identifying and screening single polynucleotide polymorphisms, insertion/deletion loci, and microsatellites is provided. The method includes adding a donor intercalating dye to a sample containing an amplified target nucleic acid sequence, adding a probe containing an acceptor fluorophore to the sample, hybridizing the probe to the... Agent: Husch Blackwell Sanders LLP
20100129815 - Identification of cardiac specific myosin light chain kinase: The subject invention pertains to the association of a MLCK homologue with cardiac tissue and methods of identifying candidate compounds that can modulate the activity of this MLCK homologue and the expression of MLCK gene product. Additionally, methods of treating heart failure are also provided by the subject invention.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100129817 - Identifying germline competent embryonic stem cells: Methods and compositions for selecting ES cells that are germline competent are provided, including gene expression arrays of from one to about 300 or more genes. Selecting ES cells that are competent for germline transmission by comparing the expression of one or more genes between an ES cell that is... Agent: Regeneron Pharmaceuticals, Inc
20100129809 - Inhibitors of rv0256c: Described herein are methods for identifying inhibitors of Rv0256c functions, e.g., inhibitors of Rv0256c expression, DNA binding, nuclear localization and iNOS inhibition.... Agent: Foley & Lardner LLP
20100129794 - Magnetic polymer particles: The present invention relates to magnetic polymer particles including magnetic particles selected from the group of ferromagnetic, ferrimagnetic and/or superparamagnetic particles, where the magnetic particles are embedded in a crosslinked polyacrylate or polyalkylacrylate matrix.... Agent: Leon R. Yankwich
20100129827 - Method and device for sample preparation control: A method for preparing a sample suspected to contain a target nucleic acid sequence for a nucleic acid amplification reaction and for verifying the effectiveness of the sample preparation comprises the step of mixing the sample with sample preparation controls. The sample preparation controls are cells, spores, microorganisms, or viruses... Agent: Townsend And Townsend And Crew, LLP
20100129803 - Method for determining dna fragmentation in microorganisms: The invention relates to a method for determining DNA integrity in microorganisms and to a kit for evaluating DNA integrity in same. Since cell death results in DNA fragmentation, the inventive method can be used to determine DNA fragmentation levels in microorganisms clearly, simply, quickly and precisely.... Agent: Ladas & Parry LLP
20100129790 - Method for determining phospholipidosis: It is intended to provide a rapid, simple and noninvasive novel in vivo method for determining phospholipidosis (PLsis) by detecting a PLsis marker gene. More specifically, it is intended to provide a method for determining phospholipidosis in a mammal comprising the step of detecting change in expression of one or... Agent: Edwards Angell Palmer & Dodge LLP
20100129814 - Method for separation and characterization of microorganisms using identifier agents: The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be... Agent: Biomerieux, Inc.
20100129825 - Method for the detection of bacterial species of the genera anaplasma/ehrlichia and bartonella: The present invention relates to a method for the detection and identification of bacterial species belonging to the genera Anaplasma/Ehrlichia and Bartonella, and also provides triggers and probes required for its application, as well as associated kits.... Agent: Darby & Darby P.C.
20100129802 - Method of sequencing a genome: A method and computer-program product for sequencing nucleic acid sequences using restriction fragment maps derived from end-sequenced nucleotide fragments. The initial nucleotide sequence can be processed to form a shot-gun-data set. The present teachings employ a technique called Restriction Site Shotgun Sequencing (RSSS.) It can reduce the amount of overlap... Agent: Life Technologies Corporation C/o Intellevate
20100129819 - Methods and compositions in particle-based detection of target molecules using linking molecules: Methods and compositions which can be used to increase the strength and/or probability of forming a binding complex comprising a target molecule and a substrate are disclosed. In one aspect, linking molecules are disclosed which can be used to increase the number of intra-complex binding interactions. Covalent bonds can be... Agent: Bozicevic, Field & Francis LLP
20100129810 - Methods and systems for nucleic acid sequencing validation, calibration and normalization: A system for performing quality control for nucleic acid sample sequencing is disclosed. The system has a set of solid supports, each support having attached thereto a plurality of nucleic acid sequences. The set has plural groups of solid supports and each group contains solid supports having the same nucleic... Agent: O'brien Jones, PLLC
20100129823 - Methods for identifying subjects susceptible to ataxic neurological disease: In one aspect, the invention provides methods of identifying genetic mutations that are associated with ataxic neurological disease. The methods comprise identifying a difference between a nucleic acid sequence of a protein kinase C gamma gene from a mammalian subject exhibiting ataxia and a nucleic acid sequence of a protein... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20100129816 - Microbial population analysis: The current invention relates to a method for analysis of a population of micro-organisms (e.g. bacterial population) of different taxonomic groups in an environment suspected to contain said bacteria, primers, primer sets and pair of primer sets suitable for use is such method, and use of such method in determining... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20100129801 - Non-invasive recovery of rna and analysis of gene expression in skin: A liquid is placed on an area of skin in which an RNA sample is to be extracted. The liquid is configured to harden which allows for the hardened material to be peeled off. In some implementations, a substrate is attached to the liquid before it hardens to facilitate removal... Agent: The Mccallum Law Firm, P. C.
20100129812 - Nucleic acid hybridization essay method: A cleavable signal element applicable to quantitative and qualitative assay devices, using a cleavable technique specifically responsive to a complementary double strand or single strand of nucleic acids, and a nucleic acid hybridization assay method and device using the cleavable signal element are provided. Using the cleavable technique responsive to... Agent: Staas & Halsey LLP
20100129808 - Particles for detecting intracellular targets: Methods describing the use of nanoparticles modified with binding moieties are provided.... Agent: Marshall, Gerstein & Borun LLP
20100129800 - Polymers and their use as fluorescent labels: The present invention relates to a polymer composed by two to ten monomers of formula (I) as well as to a process for its preparation and its use as fluorophore wherein: X is a radical of formula (II) wherein —R5 is an electron pair or a (C1-C3)-alkyl radical; —Ra and... Agent: Traskbritt, P.C.
20100129818 - Polymorphisms in genes affecting cyp2c9-related disorders and uses thereof: A method for predicting a subject's risk factors for CYP2C9-related disorders includes detecting the allelic status of one or more polymorphisms in a nucleic acid sample of the subject.... Agent: Macmillan Sobanski & Todd, LLC
20100129806 - Regulation of cell survival by hsp90 and ip6k2: Anti-cancer drugs are identified by screening for agents and compounds which inhibit the binding of HSP90 and IP6K2. In vitro and in vivo assays can be used. Any phenomenon associated with the binding or inhibition can be monitored, including cell death, subcellular localization, catalytic activity of IP6K2, and IP7 formation.... Agent: Banner & Witcoff, Ltd.
20100129805 - Slc1a1 antipsychotic drug response markers: The invention relates to methods for predicting a subject's response to antipsychotic drug treatment comprising the steps of obtaining a biological sample from the subject, and determining the presence or absence of one or more polymorphisms in the SLC1A1 gene of the subject, wherein the presence of the one or... Agent: Winston & Strawn LLP Patent Department
20100129804 - Spink1 as a prostate cancer marker and uses thereof: Compositions and methods for cancer research, diagnosis, and treatment, including but not limited to, cancer markers are provided. In particular, SPINK1 and other markers for prostate cancer are provided.... Agent: Casimir Jones, S.c.
20100129807 - Stabilization of cyclic peptide structures: In various aspects, the invention provides methods for cyclizing proteins, including methods for enhancing the stability of cyclized proteins under cytosolic conditions. The invention also provides various methods for using the cyclized proteins. For example, cyclized proteins of the invention may be used in screening assays analogous to the yeast... Agent: Klarquist Sparkman, LLP
20100129820 - Strongly quenching oligomeric excimer/quencher pairs for detection schemes: Compositions and systems are provided for the high efficiency quenching small water-soluble oligomers, or oligofluors, of from about 1-10 kd in size, where the oligofluors comprise multiple excimeric or exciplex forming fluorophores arranged on a scaffold, which are efficiently quenched by a quencher entity linked to the oligomer through a... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP
20100129797 - Use of genetic modifications in human gene chk1 which codes for checkpoint kinase 1: The invention relates to an in vitro method for predicting disease risks, progression of diseases, drug risks, success of treatment and for finding drug targets by looking for one or more genetic modifications in the promoter region of the CHK1 (CHEK1) gene on human chromosome 11q23, the genetic modifications being... Agent: Amster, Rothstein & Ebenstein LLP
20100129830 - Label independent detection biosensor composition and methods thereof: A biosensor article including a substrate; a tie-layer attached to the substrate surface; and a nanometer scale cross-linked acryloyl copolymer layer attached, for example, by copolymerization, to the tie-layer, as defined herein. Methods for making the biosensor article or cell culture article and methods for performing an assay of a... Agent: Corning Incorporated
20100129828 - Method of assaying leukocyte elastase inhibitor for the in vitro diagnosis of colorectal cancer: The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Leukocyte Elastase Inhibitor tumor marker in a biological sample taken from a patient suspected of having colorectal cancer. Said method can be used for early diagnosis, screening, therapeutic follow-up... Agent: Oliff & Berridge, PLC
20100129831 - Methods for diagnosing hypersensitivity reactions: The invention is directed to the diagnosis of allergic reactions. Particularly, the invention is directed to in vitro assays for diagnosing systemic hypersensitivity reactions, and identifying agents causing these reactions.... Agent: Fennemore Craig
20100129829 - Use of plasma hsp90 related to malignancy: The present invention concerns diagnosing and/or prognosticating cancer in an individual and/or determining response to a Hsp90-interacting therapy in an individual. In particular, the methods and compositions of the therapy relate to levels of Hsp90-α in plasma. Additional methods concern determining levels of Hsp90-associated molecules.... Agent: Fulbright & Jaworski, LLP
20100129833 - Methods to identify modulators: Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose and an inhibitor, are provided.... Agent: Curatolo Sidoti Co., Lpa
20100129834 - Autoimmune regulation of prostate cancer by annexin a3: The present invention relates to a method for the diagnosis of prostate carcinoma comprising the determination of annexin A3 (ANXA3) and/or autoantibodies against ANXA3 with a specific reagent. The method allows differentiation between benign, premalignant and malignant conditions. Further, the method has a prognostic relevance.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100129835 - Methods for selecting improved strains: The present invention relates to a system for improving a strain of filamentous fungus that is useful in producing an enzyme of interest such as a cellulase. The invention involves generating genetic diversity in a strain of fungal cells, subjecting the population of cells to selection, and isolating the cells... Agent: Danisco US Inc. Attention: Legal Department
20100129837 - Methods of capturing bacterial whole cells and methods of analyzing samples for bacteria: In certain embodiments, the invention relates to methods of capturing bacterial whole cells that includes the use of two or more antibodies having antigenic specificities for two or more distinct analytes characteristic of the specific bacterium. In certain embodiments, the invention relates to methods of analyzing a sample for a... Agent: 3m Innovative Properties Company
20100129832 - Detection method and detection reagent for autoimmune pancreatitis or fulminant type-1 diabetes: By detecting an antibody which immunologically reacts with amylase α2-A in a sample, AIP or FT1DM is examined or the possibility of developing FT1DM is determined. Detection of this antibody is for instance carried out by an immunological method using an antigen which immunologically reacts with this antibody. The antigen... Agent: Knobbe Martens Olson & Bear LLP
20100129838 - Methods for prediction of inflammatory bowel disease (ibd) using serologic markers: The present invention provides methods, systems, and code for accurately classifying whether a sample from a pediatric individual is associated with inflammatory bowel disease (IBD) or a clinical subtype thereof. In particular, the present invention is useful for classifying a sample from a pediatric individual as an IBD sample using... Agent: Townsend And Townsend And Crew, LLP
20100129839 - Method for in vitro diagnosis of pvl-producing staphylococcus aureus: The present invention relates to a method for in vitro diagnosis of Staphylococcus aureus producing Panton-Valentine Leukocidin (PVL), using a biological sample derived from an individual liable to be colonized by or infected with Staphylococcus aureus, wherein the diagnosis is carried out by detection of PVL using a routine immunological... Agent: Oliff & Berridge, PLC
20100129840 - Method and apparatus for reducing luminescent test result interferences: This application involves detecting luminescence. Various methods and devices are described that reduce interference of ambient light, including UV radiation, on test results. Such methods and devices include using UV blocking material and covering test components prior to use.... Agent: Charm Sciences, Inc.
20100129841 - Detection of a blood coagulation activity marker in a body fluid sample: The invention relates to a method for detecting in a body fluid sample at least one blood coagulation activity marker that reflects the blood coagulation activity of an individual. By correlating the amount or concentration of the blood coagulation activity marker present e.g. in a urine sample, it is possible... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20100129843 - Characterization of n-glycans using exoglycosidases: The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the... Agent: Choate, Hall & Stewart LLP
20100129842 - Isobarically labeled analytes and fragment ions derived therefrom: This invention pertains to isobarically labeled analytes and fragment ions thereof.... Agent: Life Technologies Corporation C/o Intellevate
20100129844 - Aminoacylase 1 assay method for the in vitro diagnosis of colorectal cancer: A method for the in vitro diagnosis of colorectal cancer by determining the presence of Aminoacylase 1 tumor marker in a biological sample taken from a patient suspected of having colorectal cancer. Said method can be used for early diagnosis, screening, therapeutic follow-up and prognosis, and also for relapse diagnosis... Agent: Oliff & Berridge, PLC
20100129845 - Astaxanthine biosynthesis in eukaryotes: The invention relates to a DNA vector comprising (a) a DNA sequence coding for the phytoene desaturase protein that is modified in one position by an amino add exchange providing resistance, and (b) a multiple cloning site into which any DNA sequence to be cloned. The invention also relates to... Agent: Fulbright & Jaworski, LLP
20100129855 - Blood cell analyzer, blood cell analyzing method, and computer program product: A blood cell analyzer comprising: a detector for detecting predetermined component of leukocytes contained in a specimen; and a controller, including a memory under the control of a processor, the memory storing: correlation information relating to the correlation between leukocyte distribution data and either stab neutrophil or segmented leukocyte classification... Agent: Brinks Hofer Gilson & Lione
20100129849 - Cell observation apparatus, cell observation method, and program: The present invention relates to a cell observation apparatus that facilitates the setting of schedules. An observation schedule that has already been registered is presented to a user by a time schedule display unit of a schedule setting screen, and a new observation schedule is acquired in response to an... Agent: Oliff & Berridge, PLC
20100129853 - Disease markers: The present invention relates to biomarkers for autoimmune disease, and in particular to a method for determining a status of an autoimmune disease in a test subject, comprising measuring production of IL-5 and IL-13, as well as to associated uses and kits.... Agent: Marshall, Gerstein & Borun LLP
20100129852 - Integrated bioanalyzer: The present invention relates to an in vitro assay method and device that provides for detection and measurement of entities in a fluid sample that can be captured and concentrated in a unitized self-contained enclosed filter apparatus that is analyzed in an optical detection instrument for indications of the entity.... Agent: Morgan Lewis & Bockius LLP
20100129846 - Isoform specificities of blood serum proteins and their use as differentially expressed protein biomarkers for diagnosis of breast cancer: The present invention discloses twenty two 22 protein biomarkers of breast cancer. More specifically, the present invention discloses the identities, specificities, and uses of up to twenty two (22) protein biomarkers in blood serum for distinguishing between patients with earlier and later stages of breast cancer, patients with benign breast... Agent: Benjamin A. Adler, Ph. D., J.d.
20100129854 - Liver cell toxicity assay: The disclosure provides methods for characterizing the toxicity of a candidate molecule to liver cells as defined herein; methods of culturing metabolically active liver cells on a biosensor as defined herein; and biosensor liver culture systems as defined herein.... Agent: Corning Incorporated
20100129850 - Method for analyzing the effect of a gaseous medium on a biological test system using an extracellular metabolization system and a device for carrying out the method: The invention relates to a method for analyzing the effect of a gaseous medium on a biological test system using an extracellular metabolization system. The method consists of the following steps: a biological test sample is cultivated on a permeable carrier, the gaseous medium is guided over the surface of... Agent: Collard & Roe, P.C.
20100129847 - Method for the detection of amyloid-b oligomers in body fluids: The present invention relates to a method for the detection of marker of the Alzheimer's disease, namely the amyloid-β oligomers in human CSF, using a combination of steps including demasking the epitopes responsible for antibody binding on the Aβ peptide oligomers as well as detecting fluorescently marked antibodies binding to... Agent: Townsend And Townsend And Crew, LLP
20100129856 - Methods and devices for cell signaling under pulse stimulation: The disclosure provides a device for measuring cellular responses under controlled environments. The disclosure also provides an array of devices for measuring cellular responses under controlled environments. The disclosure also provides methods to study cell signaling using the devices. By using microfluidics, the disclosure enables study of cell signaling under... Agent: Corning Incorporated
20100129851 - Methods of diagnosing muscle damage: A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage, and evaluating the sample for the presence or absence of a myofilament protein modification product. Preferably, the myofilament protein... Agent: Clark & Elbing LLP
20100129848 - Rapid mixing device for subsecond analysis of cell surface kinetics in flow cytometry: The present invention provides improved flow cytometry tubes containing ports to allow rapid addition and mixing of reagents with sample during flow cytometry. The present invention further provides rapid mixing cytometry devices and method for their use in rapid reagent mixing during flow cytometry.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20100129858 - Method for separation, characterization and/or identification of microorganisms using spectroscopy: The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be... Agent: Biomerieux, Inc.
20100129857 - Methods for the isolation and identification of microorganisms: The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be... Agent: Biomerieux, Inc.
20100129859 - Apparatus and methods for automated handling and embedding of tissue samples: An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports... Agent: Wood, Herron & Evans, LLP
20100129860 - Methods of producing the cellulolytic enhancing activity of a polypeptide: The present invention relates to methods of increasing the activity of a polypeptide having cellulolytic enhancing activity, comprising: adding a soluble activating divalent metal cation to a composition comprising the polypeptide having cellulolytic enhancing activity, wherein the presence of the soluble activating divalent metal cation and the polypeptide having cellulolytic... Agent: Novozymes, Inc.
20100129861 - Isolation and use of novel mammalian dexh box helicases: The present invention relates to the isolation, purification, and use of novel mammalian DExH box helicases. In particular, the present invention relates to the isolation, purification and use of DHX29, a novel mammalian RNA helicase.... Agent: Hoffmann & Baron, LLP
20100129868 - Delta 4,5 glycuronidase compositions and methods related thereto: The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.... Agent: Wolf Greenfield & Sacks, P.C.
20100129865 - Ketose 3-epimerase, its preparation and uses: An object of the present invention is to provide a novel ketose 3-epimerase, a process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, and a process for producing a ketose by using the enzyme. The present invention solves the above objects... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20100129867 - Method for producing dipeptide:
20100129866 - Method for production of dipeptide: According to the present invention, a protein having dipeptide-synthesizing activity, a DNA encoding the protein, a recombinant DNA containing the DNA, a transformant obtained via transformation with the recombinant DNA, a process for producing a protein having dipeptide-synthesizing activity using the transformant or the like, a process for producing a... Agent: Darby & Darby P.C.
20100129864 - Novel bacteriocins, transport and vector system and method of use thereof: New bacteriocins capable of inhibiting the growth of bacteria are disclosed, along with methods of obtaining secretion of proteins from lactic acid bacteria, and methods for protecting foodstuffs.... Agent: William J Bundren The Law Office Of William J Bundren
20100129862 - Novel lipolytic enzyme lip1: The present invention provides a novel nucleic acid sequence, designated LIP1, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for... Agent: Janet K. Castaneda Genencor International, Inc.
20100129863 - Optimized core promoters and uses thereof: The present invention provides core promoter motif ten elements (MTE) and core promoter constructs comprising the MTEs and an initiator element (Inr) in combination with one or both of a TATA box and a downstream promoter element (DPE) which increases gene expression over the strongest known core promoters. Particularly, an... Agent: Adler & Associates
20100129869 - Methods and compositions for inactivating glutamine synthetase gene expression: Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.... Agent: Robins & Pasternak
20100129873 - Highly parallel gel-free cloning method: A highly parallel method for gene cloning is presented. PCR products can be isolated using a solid phase and ligated into a positive selection vector. The cloning method has a very high success rate and can be performed entirely by a liquid handling robot with very little human intervention.... Agent: Phynexus, Inc.
20100129870 - Method for obtaining oligonucleotide: h
20100129871 - Pyrophosphorolysis activated polymerization (pap): A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3′-deoxynucleotide at its 3′ terminus. PAP can be applied for exponential amplification or for linear... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100129872 - System and method for movement and positioning of reaction mixture during nucleic acid amplification: A system for accurately positioning a reaction mixture during amplification of a nucleic acid includes a reaction vessel that contains the reaction mixture, a first heat exchanger, a second heat exchanger and a pump assembly. The reaction vessel can include .a first zone and a second zone. The first heat... Agent: James P. Broder Roeder & Broder LLP
20100129875 - Emulsion pcr and amplicon capture: Compositions and methods of use are disclosed for clonally amplifying target polynucleotide sequences in solution and attaching the amplicons to a surface by activation of a masked binding moiety.... Agent: Life Technologies Corporation C/o Intellevate
20100129874 - Method for multiplexed nucleic acid patch polymerase chain reaction: The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.... Agent: Polsinelli Shughart PC
20100129876 - Pasting edge heater: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.... Agent: Life Technologies Corporation C/o Intellevate
20100129878 - Methods for nucleic acid amplification: The present invention provides methods for amplifying nucleic acid after isolating nucleic acid from a sample using functionalized support material.... Agent: 3m Innovative Properties Company
20100129877 - Modification of rna, producing an increased transcript stability and translation efficiency: It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be possible to obtain increased grades of expression by using said RNA in gene therapy approaches.... Agent: Keown & Zucchero, LLP
20100129879 - Genome partitioning using a nicking endonuclease: A method for partitioning a genome is provided. In certain embodiments, the method comprises: a) nicking a region of the genome using a sequence-specific nicking endonuclease to produce a nicked double-stranded genomic region; b) hybridizing the nicked double-stranded genomic region with an oligonucleotide comprising: i. an affinity tag; and ii.... Agent: Agilent Technologies Inc.
20100129880 - Hosts and fermentation processes for cellulase production: A fermentation process for the production of cellulase mixtures is provided. The process comprises providing a genetically modified host filamentous fungus that overexpresses a Xyr1 transcription factor and/or that is partially or completely deficient in expressing one or more hemicellulase enzyme. The host filamentous fungus is cultured in a medium... Agent: Fitzpatrick Cella Harper & Scinto
20100129881 - Antigenic polysaccharides and process for their preparation: A robust and industrial scale process to afford highly pure antigenic polysaccharides is claimed.... Agent: Fish & Richardson P.C.
20100129882 - Hydrolases, nucleic acids encoding them and methods for making and using them: Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils,... Agent: Jones Day
20100129883 - Substrate-selective co-fermentation process: Biological method for conversion of a lignocellulosic hydrolysate into a desired biochemical product. Use of a plurality of substrate-selective cells allows different sugars in a complex mixture to be consumed concurrently and independently. The method can be readily extended to remove inhibitory compounds from hydrolysate.... Agent: Mueting, Raasch & Gebhardt, P.A.
20100129884 - Process for producing fermentation product from carbon sources containing glycerol using corynebacteria: The present invention relates to a method for producing fermentation product from various carbon sources containing glycerol using Corynebacteria. More particularly, the present invention relates to a method for producing fermentation product from carbon sources containing glycerol or a part of glycerol with high yield and high productivity, by fermenting... Agent: Swanson & Bratschun, L.L.C.
20100129887 - Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis: Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes include threonine deaminase, isopropylmalate synthase, and optionally branched chain amino acid transaminase.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20100129885 - Methods for the production of n-butanol: Embodiments of the present invention include methods for the production of four carbon alcohols, specifically n-butanol, by a consolidated bioprocessing approach for the conversion of cellulosic material to the desired end product. According to some embodiments, recombinant microbial host cells are provided, preferably S. cerevisiae, that are capable of converting... Agent: Ivor R. Elrifi Mintz Levin Cohn Ferris Glovsky And Popeo PC
20100129886 - Production of isobutanol in yeast mitochondria: Yeast cells with modified expression of certain enzyme activities in the mitochondria are described for isobutanol production. Modifications described provide an isobutanol biosynthesis pathway in the yeast mitochondria.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20100129888 - Liquefaction of starch-based biomass: The present invention provides processes for the treatment of a starch-based feedstock. The processes include mixing together a starch-based feedstock and a working fluid to form a slurry, hydrating the starch-based feedstock with the working fluid, adding an enzyme to the slurry, pumping the slurry into a substantially constant diameter... Agent: Kevin C. Hooper, Esq. Bryan Cave LLP
20100129889 - Affinity separation methods and systems: An affinity matrix comprising a base matrix containing biotin; and a fusion protein attached to the base matrix, wherein the fusion protein contains a matrix binding element capable of binding to the base matrix via biotin and a target binding element capable of binding, or being bound by, at least... Agent: Morgan Lewis & Bockius LLP
20100129890 - Cytochrome p450 enzyme complexes and methods of treatment using the same: The present invention provides methods and compositions for balancing electron reduction potentials of formulations in a manner that reduces susceptibility to changes from xenobiotics. The present invention also provides novel compositions of matter based on structuring from a mobile nucleotide integral to its architecture.... Agent: Nields, Lemack & Frame, LLC
20100129891 - Bilirubin oxidase mutant having thermal stability: A heat-resistant bilirubin oxidase mutant is disclosed. The bilirubin oxidase mutant is obtained by deletion, replacement, addition or insertion of at least one amino acid residue of a wild type amino sequence of SEQ. ID. No. 1 of a bilirubin oxidase derived from an imperfect filamentous fungus, Myrothecium verrucaria. A... Agent: K&l Gates LLP
20100129892 - Process for the preparation of 1,3-propanediol by a recombinant micro-organism in the absence of coenzyme b12 or one of its precursors: The invention concerns a method for preparing 1,3-propanediol from a carbon-containing substance, said method comprising a step which consists in culturing a recombinant micro-organism not producing coenzyme B12 in the absence of coenzyme B12 or one of its precursors. The invention also concerns a nucleic acid coding for a glycerol... Agent: Fulbright & Jaworski L.L.P.
20100129893 - Optimal placement of a robust solvent/detergent process post viral ultrafiltration of an immune gamma globulin: The solvent-detergent (S/D) process is used to inactivate enveloped viruses in plasma products. While concentrations of 1.0% detergent and 0.3% tri-n-butyl phosphate solvent have been considered necessary for robust removal of viral activity, we show the effectiveness of solvent-detergent treatment after fractionation and nanofiltration of an immune gamma globulin preparation,... Agent: Philip S. Johnson Johnson & Johnson
20100129894 - Method for regenerating a biosensor: In a method for regenerating a biosensor, a biosensor is prepared having a substrate surface on which at least one receptor is immobilized. At least one ligand that is binding specific to the receptor is bound to the receptor, said ligand, together with the receptor, forming a ligand-receptor complex. To... Agent: The Webb Law Firm, P.C.
20100129895 - Biofiltration system for odor control: The invention involves the creation of a corrosion resistant gas treatment system comprising a unitary housing subdivided into at least two internal sections, the only connection between the first and the following section(s) is a gas only passage channel; the design allows the simultaneous remediation of contaminants from multiply contaminated... Agent: William S. Bernheim
20100129896 - System for differentiating the lengths of nucleic acids of interest in a sample: Systems for differentiating the lengths of nucleic acids of interest in a sample are provided. The system includes a microfluidic device, a detector, and a software system. The microfluidic device includes an amplification microchannel or microchamber containing a reaction mixture under conditions that provide one or more amplicons of the... Agent: Caliper Life Sciences, Inc.
20100129897 - Biological component-measuring unit, biological component-measuring unit package, medical support instrument kit, and medical support instrument kit package: A biological component-measuring unit, a package of a biological component-measuring unit, a medical support instrument kit, and a package of a medical support instrument kit, for improving workability and enabling the measurement of components of body fluids hygienically. The biological component-measuring unit comprising a substrate detachably mountable on a medical... Agent: Darby & Darby P.C.
20100129898 - Reagent delivery system: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP
20100129899 - Flexible bioreactor: A flexible bioreactor intended for culturing cells in a liquid medium, the bioreactor comprising a flexible wall forming a fluid impermeable bottom wall of the bioreactor when in use, wherein flexible parts of said flexible bottom wall are interrupted by at least one rigid element of said flexible bottom wall,... Agent: Banner & Witcoff, Ltd.
20100129900 - Layered flask cell culture system: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of flexible cell culture compartments in combination with a spacer material maintaining air space(s). The expandable compartments of the cell culture apparatus have imparted therein... Agent: Millipore Corporation
20100129901 - Hepatitis c virus vaccine: The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell... Agent: Merck
20100129903 - Pitx3 expression promoters: Isolated polynucleotides comprising a PITX3 promoter are provided, where a PITX3 regulatory element is operably joined to a PITX3 basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest,... Agent: Bozicevic, Field & Francis LLP
20100129904 - Recombinant human interferon-like proteins: This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host... Agent: Oyen, Wiggs, Green & Mutala LLP 480 - The Station
20100129902 - Replication stable and rnase resistant chimeras of pestivirus with insertion in 3' nontranslated region (3'ntr): The invention relates to the field of nucleic acid amplification, particularly to quality control materials for use in viral RNA assays. It specifically relates to the construction of a recombinant Pestivirus by the identification of a region in the 3′NTR of the viral RNA genome where additional sequence elements can... Agent: Orrick, Herrington & Sutcliffe, LLPIPProsecution Department
20100129905 - Mammalian cytokines; related reagents and methods: Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Merck Patent Department (k-6-1, 1990)
20100129907 - Human foreskin fibroblast conditioned media for culturing es cells: A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20100129906 - Method for obtaining xeno-free hbs cell line: c
20100129908 - Spaced projection substrates and devices for cell culture: An article for culturing cells includes a substrate on which cells can be cultured. The substrate has a base surface. An array of projections extends from the base surface. The projections have a height of about 1 micrometer to about 100 micrometers, and have a gap distance along the major... Agent: Corning Incorporated
20100129909 - Device and method for treating biomass: A method for pretreating and disrupting cell structure of biomass by subjecting the biomass to high pressure, thereby disrupting the cell structure of the biomass is provided. Also provided is a device for performing the method, wherein the device includes a cavitating device and a cell structure disrupting device disposed... Agent: Furr Law Firm
20100129910 - Cell matrix related compositions and their use for generating embryoid bodies: The present invention relates to compositions and methods for the generation of embryoid bodies from embryonic stem cells, and for aggregation of ES cells for establishing ES cell colonies from small numbers of cells. Compositions of the invention, in certain embodiments, comprise embryonic stem cells, an extracellular matrix molecule, and... Agent: Stahl Law Firm
20100129912 - 3d cell-culture article and methods thereof: An optically clear, porous polymer composition, an article incorporating the composition, and methods for making and using the composition for cell culture including, for example, regulating or promoting cell function or gene expression as defined herein.... Agent: Corning Incorporated
20100129911 - Nanoparticulate affinity capture for label independent detection system: where (x), (y), (z), R, R′, R″, S, W, and X, are as defined herein. Methods for making the biosensor article or cell culture article and methods for performing an assay of a ligand with the biosensor article are also disclosed.... Agent: Corning Incorporated
20100129913 - Polioma vector expressing long double-stranded rnas: Polyoma viral vector production cell line comprising a heterologous polynucleotide sequence that is capable of being transcribed into an RNA sequence that is capable of folding into double stranded RNA of at least 50 base pairs in length, methods of producing said cell line, uses thereof and recombinant polyoma viral... Agent: Andrus, Sceales, Starke & Sawall, LLP
20100129914 - Tol1 factor transposase and dna introduction system using the same: An object is to provide a Tol1 element transposase and a use thereof. Provided is a Tol1 element transposase containing (a) a protein having the amino acid sequence of SEQ ID No: 1 or (b) a protein having an amino acid sequence homologous to the amino acid sequence of SEQ... Agent: Edwards Angell Palmer & Dodge LLP
20100129915 - Methods for inducing cardiomyogenesis: The present invention provides methods of inducing cardiomyogenesis and expansion of cardiac progenitors in a population of stem cells or progenitor cells, the methods generally involving inducing a canonical Wnt signaling pathway in the stem cells or progenitor cells. The present invention provides methods of generating a population of cardiomyocytes... Agent: Bozicevic, Field & Francis LLP
20100129916 - Expression of toxic genes in vivo in a non-natural host: Compositions and methods are provided for expression of a toxic protein in a host cell preferably a bacterial host cell where at least one T7 RNA polymerase gene Is contained on the host cell chromosome and one or more genes encoding a T7 RNA polymerase inhibitor is located on an... Agent: Harriet M. Strimpel, D. Phil.05/20/2010 > patent applications in patent subcategories. archived by USPTO category
20100124750 - Analyzing methods and devices for biological reactions between a liquid phase and a solid phase: The invention relates to a device for performing immunological, histochemical and cytochemical, molecular biological, enzymological, clinical-chemical and other analyses, wherein the device comprises an object holder having one or more elongate adhesive surfaces and a reagent holder having one or several channels. The object holder is detachably connectable to the... Agent: Seed Intellectual Property Law Group PLLC
20100124747 - Compositions and methods for diagnosis or prognosis of testicular cancer: Provided are compositions and methods for diagnosis or prognosis of testicular or male germ-cell derived cancer, comprising: obtaining sperm DNA from a test subject; determining the methylation status of at least one CpG dinucleotide sequence of at least one gene sequence selected from HRAS, NTF3, MT1A, PAX8, DIRAS3, PLAGL1, SFN,... Agent: Davis Wright Tremaine, LLP/seattle
20100124749 - Compositions, kits and methods for detection of campylobacter nucleic acid: The disclosed invention is related to compositions, kits and methods comprising one or more oligomers targeting 16S rRNA target nucleic acid from Campylobacter species jejuni, coli and/or lari. Compositions include amplification oligomers, detection probe oligomers and/or target capture oligomers. Kits and methods comprise at least one of these oligomers.... Agent: Gen Probe Incorporated
20100124744 - Detection of target variants using a fluorescent label and a soluble quencher: Methods, reaction mixtures and systems for detecting the presence or absence of a target nucleic acid variant from a selection of possible variants is described.... Agent: Townsend And Townsend And Crew, LLP
20100124743 - Method for diagnosis of cancer: Disclosed is a method for diagnosing cancer with high accuracy through quantification of cancer cell-derived DNA, which comprises the steps of: (1) extracting free DNA from a plasma collected from a test subject; (2) quantifying the extracted free DNA and calculating the free DNA content per unit volume of the... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20100124746 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20100124748 - Method for the specific detection of low abundance rna species in a biological sample: The present invention relates to a method and a kit for the detection of low abundance RNA species in a biological sample and to a method and a kit for the detection of a mycoplasma contamination in a biological sample.... Agent: Townsend And Townsend And Crew LLP
20100124739 - Methods and compositions for diagnosing pelvic floor dysfunction: The present invention relates to, among other things, methods and compositions for diagnosing and preventing pelvic floor dysfunction, genital prolapse, and similar medical conditions. For example, according to certain embodiments of the present invention, methods of diagnosing genital prolapse and/or pelvic floor dysfunction are provided. Such methods generally comprise (1)... Agent: Bryan Cave LLP
20100124742 - Methods and compositions to identify increased risk of breast cancer by detection of cpg island methylator phenotype (cimp): The present invention is directed to kits and methods for identifying a female subject as having an increased risk of developing breast cancer, comprising detecting a CPG island methylator phenotype (CIMP) in nucleic acid of the subject.... Agent: Myers Bigel Sibley & Sajovec
20100124741 - Methods for detecting igh/bcl-1 chromosomal translocation: The invention provides methods for detection of Bcl-1 nucleic acid in acellular body fluid. The methods can be used to detect the IgH/Bcl-1 translocations (11;14)(q13;q32) in acellular body fluid. The chromosomal translocation (11;14)(q13;q32) is often associated with mantle cell (centrocytic) lymphoma and occasionally in other B-cell neoplasms, notably myeloma. The... Agent: Foley & Lardner LLP
20100124745 - Methods ofr the detection of gene trannscripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP
20100124751 - Non-invasive fetal genetic screening by digital analysis: The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies... Agent: Peters Verny , L.L.P.
20100124752 - Non-invasive fetal genetic screening by digital analysis: The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies... Agent: Peters Verny , L.L.P.
20100124740 - Somatic transfer of modified genes to predict drug effects: The present invention relates to somatic cell gene transfer methods for mimicking one or more effects of a drug candidate compound. In one aspect, the methods mimic the effect of a drug candidate compound with potential to potentiate or suppress activity of a selected target molecule. In another aspect, the... Agent: Edwards Angell Palmer & Dodge LLP
20100124753 - System and method for identifying erythropoietin-responsive genes: The present invention relates to the generation of a population of Epo-responsive marrow derived cells that express Epo-responsive genes and gene products. The present invention also relates to the detection of Epo-responsive genes and gene products as well as to the detection of the administration of Epo, Epo-derivatives and Epo-mimetics... Agent: Kevin Farrell Pierce Atwood
20100124754 - Cloning, expression and purification of recombinant porcine intrinsic factor for use in diagnostic assay: The present invention relates to a new method of producing functionally active recombinant porcine Intrinsic Factor as well as the protein (i.e., porcine Intrinsic Factor) produced thereby. In particular, the vector comprising the DNA encoding the protein is introduced into a Chinese Hamster Ovary (CHO) host cell under conditions sufficient... Agent: Paul D. Yasger Abbott Laboratories
20100124755 - Prostate cancer and melanoma antigens: Methods for identifying a human subject as a candidate for further prostate cancer or melanoma examination are disclosed. Also disclosed are methods for determining whether an immune therapy has elicited a tumor-specific immune response in a prostate cancer or melanoma patient. Further disclosed are kits that can be used to... Agent: Quarles & Brady LLP
20100124756 - Collection of biomarkers for diagnosis and monitoring of alzheimer's disease in body fluids: The inventors have discovered sets of proteinaceous biomarkers (“AD biomarkers”) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease. The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for... Agent: Morrison & Foerster LLP
20100124757 - Gold nanoparticle based protease imaging probes and use thereof: Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell... Agent: Ostrolenk Faber Gerb & Soffen
20100124758 - Apparatus and method for detecting glycol: A method and apparatus are provided for detecting contaminants, such as ethylene glycol and diethylene glycol, in various materials, including household products, and medicines. The contaminants can be detected using enzyme assays that produce measurable changes in light absorption and/or light fluorescence.... Agent: Grossman, Tucker, Perreault & Pfleger, PLLC
20100124759 - Microfluidic droplets for metabolic engineering and other applications: The present invention relates generally to the use of droplets to culture and/or assay cells or other species. In some cases, the cells or other species may be sorted based upon the results of the culture and/or assay. In some embodiments, cells other species can be encapsulated in droplets and... Agent: Wolf Greenfield & Sacks, P.C.
20100124762 - Fluidized bed detector for continuous, ultra-sensitive detection of biological and chemical materials: The present invention is generally directed to a fluidized bed detector for continuous detection of biological and chemical materials comprising a fluidized bed of detecting elements suspended in a continuous flow system wherein the detecting elements remain in the system when a first force trying to move the detecting elements... Agent: Naval Research Laboratory Associate Counsel (patents)
20100124761 - Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision: The accuracy and/or precision of measurements of extracellular acidification rate or CO2 evolution in cell culture medium may be improved by using materials with low CO2 permeability for medium-containing vessels.... Agent: Goodwin Procter LLP Patent Administrator
20100124760 - Zinc test strip and method for the detection of semen: The present invention relates to a forensic test strip and method for the detection of semen. This strip is comprised of a paper element coated with reagents which react to the presence of zinc, a component of semen, and is affixed to a plastic backing to facilitate testing items without... Agent: Stephen P. Ashburn
20100124763 - Method for detection, characterization and/or identification of microorganisms in a sealed container: The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample. The method may be accomplished in a sealed container by utilizing a first step time-dependent spectroscopic technique to obtain at least two measurements of a growth composition... Agent: Biomerieux, Inc.
20100124764 - Single chain antibody library design: The invention provides polynucleotide vectors and linkers and methods for designing and making single chain variable fragment (“ScFv”) libraries. The invention also provides polynucleotide vectors and linkers and methods for reformatting the ScFv library into Fab and IgG formats for high throughput production and screening.... Agent: Wyeth LLC Patent Law Group
20100124766 - Apparatus and method for segmented thermal cycler: The present invention relates to a thermal cycler for the carrying out of chemical or biological reactions, such as PCR or other nucleic acid amplification reactions, that is segmented with a plurality of reaction vessel receiving elements. The reaction vessel receiving elements are thermally isolated from each other and provide... Agent: Life Technologies Corporation C/o Intellevate
20100124765 - Sequence amplification with target primers: The present disclosure relates to the amplification of target nucleic acid sequences for various sequencing and/or identification techniques. This can be accomplished via the use of target primers. The use of these target primers, as described herein, allows for the reduction in the amplification of undesired hybridization events (such as... Agent: Life Technologies Corporation C/o Intellevate
20100124768 - Compositions and methods for the assembly of polynucleotides: The present invention provides compositions and methods for rapid assembly of one or more assembled polynucleotides from a plurality of component polynucleotides. The methods of the invention utilize circular nucleic acid vectors that comprise a DNA segment D flanked by an annealable linker sequence, annealable linker sequence pairs LA and... Agent: Jones Day
20100124767 - Microarray synthesis and assembly of gene-length polynucleotides: There is disclosed a process for in vitro synthesis and assembly of long, gene-length polynucleotides based upon assembly of multiple shorter oligonucleotides synthesized in situ on a microarray platform. Specifically, there is disclosed a process for in situ synthesis of oligonucleotide fragments on a solid phase microarray platform and subsequent,... Agent: Proskauer Rose LLP
20100124771 - Delignification of biomass with sequential base treatment: e) contacting at least a portion of the polysaccharide-enriched solid fraction with an enzyme consortium to produce a saccharification product comprising xylose and glucose monomers wherein the overall yield of xylose and glucose monomers in the saccharification product are individually at least about 50%.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20100124769 - Methods and compositions for degrading cellulosic material: The present invention relates to enzyme compositions comprising a polypeptide having cellobiohydrolase II activity, a polypeptide having xylanase activity, and one or more cellulolytic proteins and their use in the degradation or conversion of cellulosic material.... Agent: Novozymes, Inc.
20100124770 - Process for producing a concentrated sugar solution by enzymatic saccharification of polysaccharide enriched biomass: Methods for obtaining concentrated sugar solution from polysaccharide enriched biomass by contacting biomass with water and at least one nucleophilic base to produce a polysaccharide enriched biomass comprising a solid fraction and a liquid fraction and then contacting the solid fraction with saccharification enzyme consortium to produce a saccharification product... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20100124772 - Process for producing a sugar solution by combined chemical and enzymatic saccharification of polysaccharide enriched biomass: Concentrated sugar solutions obtained from polysaccharide enriched biomass by contacting biomass with water and at least one nucleophilic base to produce a polysaccharide enriched biomass comprising a solid fraction and a liquid fraction and then contacting enriched biomass with a dilute mineral acid selected from the group consisting of sulfuric... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20100124773 - Methods and processes for producing esters: Methods are provided for producing esters. The methods comprise converting a fermentable carbon source to organic acids by fermentation with organic acid producing microorganisms, followed by catalytic esterification. The methods comprise integrated fermentation, extraction, and esterification reactions wherein the organic acids produced during fermentation are extracted into an extraction solvent... Agent: Dinsmore & Shohl LLP
20100124774 - Method of producing biofuel using sea algae: The present invention relates to a method of producing biofuel, more specifically a method of producing biofuel comprising the steps of generating monosugars from marine algae, or from polysaccharides extracted from marine algae by treating the marine algae or the polysaccharides with a hydrolytic enzyme and/or a hydrolytic catalyst; and... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20100124775 - Process for treating cultured cells: According to the present invention, a process for treating cultured cells is provided, which comprises the steps of: a) providing planar, two-dimensional objects (“flakes”), wherein these objects comprise a material which, upon application of an extrinsic stimulus, is transferred from the planar state into a rolled state, b) providing cells... Agent: Philips Intellectual Property & Standards
20100124776 - Allografts combined with tissue derived stem cells for bone healing: There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the... Agent: Holland & Hart, LLP
20100124777 - Bacterium producing l-glutamic acid and method for producing l-glutamic acid: L-Glutamic acid is produced by culturing a coryneform bacterium having L-glutamic acid producing ability, in which trehalose synthesis ability is decreased or deleted by, for example, disrupting a gene coding for trehalose-6-phosphate synthase, a gene coding for maltooligosyltrehalose synthase, or both of these genes to produce and accumulate L-glutamic acid... Agent: The Nath Law Group
20100124778 - Forensic test strip and method for the detection of semen: The present invention relates to a forensic test strip and method for the detection of semen. This strip is comprised of a paper element coated with reagents which react to the presence of acid phosphatase (AP), an enzyme found in semen, and is sandwiched between a clear plastic cover and... Agent: Stephen P. Ashburn
20100124779 - Two-step moulded capillary: Reaction containers, such as plastic capillaries having an optimized volume-to-surface ratio that are suitable for real-time nucleic acid amplification (rtPCR) applications are disclosed as well as a method for the production of the reaction containers, in particularly the trtPCR plastic capillaries via a 2-step molding process. In the process, a... Agent: Dinsmore & Shohl, LLP Fifth Third Center
20100124780 - Gynecological container cap having a boundary configured to detach a gynecological sampler from a sampling device: A cap for a container is described that is configured to retain a gynecological sample collected with a sampling device. The cap includes a peripheral wall extending between a base and a flange opposite the base, and a diaphragm extending from the base of the peripheral wall. The flange projects... Agent: Dicke, Billig & Czaja
20100124781 - Pluripotent stem cell culture on micro-carriers: The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on micro-carriers.... Agent: Philip S. Johnson Johnson & Johnson
20100124782 - Composition for repairing defect in skin or gingival soft tissue and method of culturing autologous fibroblasts: The above-mentioned problems are solved by a method of producing an aggregate of autologous fibroblasts which comprises the step of culturing autologous fibroblasts in a culture medium with vitamin C added and the step of culturing autologous fibroblasts by a culture method selected from among rotary culture, shaking culture and... Agent: Lawrence Y.d. Ho & Associates Pte Ltd
20100124783 - Methods and compositions for cell attachment and cultivation on planar substrates: The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on planar substrates lacking an adlayer and a feeder cell layer.... Agent: Philip S. Johnson Johnson & Johnson05/13/2010 > patent applications in patent subcategories. archived by USPTO category
20100120013 - Procedure for long term corneal culture: A method for long-term multi-species cornea culture and preservation is provided. Excised mammalian corneas are preserved with structural integrity by filling the endothelial cavity with a plug material. Plugged corneas are sterile-cultured for more than 21 days via an air-interface culture where nutrients from a culture media are supplied to... Agent: Paul And Paul
20100120014 - Stability drying: A method of formulating high ambient temperature (room temperature and above) stable biologics (biologically active macromolecules, enzymes, serums, vaccines, viruses, pesticides, drug delivery systems, liposomes, cells suspensions, sperm, erythrocytes, other blood cells, stem cells, multicellular tissues, skin, heart valves) including secondary drying comprising at least two steps of stability drying... Agent: Victor Bronshtein, Ph.d.
20100120015 - Method of collecting placental stem cells: A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from... Agent: Jones Day
20100120019 - Detection, screening, and diagnosis of hpv-associated cancers: Embodiments of the invention provide methods, polyclonal antibodies, monoclonal antibodies, assays, and kits for detecting HPV infection, including infection by various HPV genotypes, early and/or late HPV-associated or HPV-specific proteins or antibodies. Monoclonal antibodies are used to detect oncogenic high risk and low risk HPV types in a single assay,... Agent: Shuling Cheng
20100120020 - Fluorescent neutralization and adherence inhibition assays: The present invention comprises rugged, inexpensive, reliable, and sensitive laboratory assays of antibody-based viral neutralization activity and antibody-based viral adherence inhibition activity. The assays use inactivated, fluorescently-labeled virus, allowing the tests to be performed without extensive safety precautions. The interaction of the labeled virus with target cells is monitored using... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.
20100120021 - Hpv e6, e7 mrna assay and methods of use thereof: Provided is an HPV E6, E7 mRNA assay, referenced herein as the “In Cell HPV Assay,” that is capable of sensitive and specific detection of normal cervical cells undergoing malignant transformation as well as abnormal cervical cells with pre-malignant or malignant lesions. The In Cell HPV Assay identifies HPV E6,... Agent: Bozicevic, Field & Francis LLP
20100120018 - Integrated active flux microfluidic devices and methods: The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g.,... Agent: Townsend And Townsend And Crew, LLP
20100120016 - Methods and systems for detection of contaminants: An impedance biosensor for detecting a contaminant in a starting material, the biosensor comprising a housing, an input device supported by the housing, an output device supported by the housing, a microfluidic cell supported by the housing, the starting material being engagable with the microfluidic cell, and an impedance analyzer... Agent: Michael Best & Friedrich LLP
20100120017 - Rapid immune chromatographic detection by amplification of the colloidal gold signal: The present invention relates to a rapid immunochromatographic test device suitable to detect more than one target in a single assay at the same time, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the... Agent: Patent Central LLC Stephan A. Pendorf
20100120038 - Assay methods for increased throughput of samples and/or targets: The present invention provides assay methods that increase the number of samples and/or target nucleic acids that can be analyzed in a single assay.... Agent: Weaver Austin Villeneuve & Sampson LLP
20100120048 - Assays for short sequence variants: The invention provides assays that can detect multiple genetic variants of a gene (e.g., a mycobacterium gene) in a sample using a pool (using 2, 3, 4, or more) of oligonucletide hybridization probes.... Agent: Fox Rothschild LLP Princeton Pike Corporate Center
20100120050 - Biomarkers for assessing altherosclerotic potential: The invention also provides methods, apparatuses and reagents useful for predicting future atherosclerosis based on expression levels of genes selected from the set of 68 genes with differential expression in response to pioglitazone and rosiglitazone. The invention also discloses reagent sets and biomarkers for predicting progression of atherosclerosis induced by... Agent: Entelos, Inc. C/o Law Offices Of Karen E. Flick
20100120049 - Biomarkers for serious skin rash: The present invention provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly Serious Skin Rash (SSR), including such severe adverse reactions such as Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). The invention also provides a method of identifying a subject afflicted with... Agent: Wilmerhale/dc
20100120025 - Compositions and methods for prognosis, diagnosis, prevention and treatment of cancers: The present invention provides compositions and methods of using the EPHB2 gene or its related signaling pathways to detect, prognosticate, assess the risk of, prevent, or treat cancers. Cancers amenable to the present invention include, but are not limited to, prostate cancer, breast cancer, and neuroblastoma. In one aspect, the... Agent: Jeffrey M. Jackson
20100120051 - Cyanine dye compounds: wherein W forms one or two fused 5- or 6-membered aromatic rings, a has a value of 0 or 1, n has a value of 0, or 1, X is O, S, or Se, and D is a pyridinium, or quinolinium moiety, provided that the compound has at least one... Agent: Life Technologies Corporation C/o Intellevate
20100120023 - Detection of macromolecular complexes with harmonic cantilevers: Method and apparatus which uses harmonic cantilevers, such as used in atomic force microscopy, to detect variations in the attractive and repulsive forces on a solid surface as a result of macromolecular binding, for example, hybridization of a single stranded DNA molecule attached to the surface with another DNA molecule.... Agent: Peters Verny , L.L.P.
20100120030 - Extracellular serine protease: The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs... Agent: Benjamin Aaron Adler Adler & Associates
20100120046 - Genetic markers for assessing risk of developing bipolar disorder: This document provides methods and materials related to genetic markers of Bipolar Disorder (BD) and Schizophrenia (SZ). For example, methods for using such genetic markers to assess risk of developing BD and/or SZ are provided, as are methods for making a differential diagnosis between BD and SZ.... Agent: Fish & Richardson PC
20100120040 - Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof: The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid... Agent: Celera Corporation
20100120045 - Genetic variants useful for risk assessments of coronary artery disease and myocardial infarction: The invention relates to methods of risk assessment and diagnosis of susceptibility to coronary artery disease and myocardial infarction, by assessing the presence or absence of alleles of certain polymorphic markers found to be associated with coronary artery disease and myocardial infarction. The invention also relates to methods for use... Agent: Marshall, Gerstein & Borun LLP
20100120024 - Materials and methods for the generation of transcripts comprising modified nucleotides: Materials and Methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence.... Agent: Mintz, Levin, Cohn, Ferris, Glovskyand Popeo, P.C.
20100120035 - Method for accurate assessment of dna quality after bisulfite treatment: The present invention is directed to methods useful for determining DNA quality after bisulfite treatment. The methods include a PCR-based assay, which allows ab-initio assessment of the DNA quality after bisulfite treatment and can help to prevent inaccurate quantitative measurement resulting from poor bisulfite treatment.... Agent: Grant Anderson LLP C/o Portfolioip
20100120036 - Method for amplifying dna fragment: (5) heating the double-stranded DNA fragment obtained in step (4), thereby dissociating the double-stranded DNA fragment and then performing a polymerase chain reaction to selectively amplify a DNA fragment having the cleavage end of the first restriction enzyme and the cleavage end of the second restriction enzyme.... Agent: Birch Stewart Kolasch & Birch
20100120037 - Method for isolating and culturing unculturable microorganisms: The invention provides a method for isolating and culturing a previously unculturable microorganism, which comprises: (i) collecting a sample from an environmental source; (ii) counting/estimating the number of microorganisms in the sample; (iii) diluting the sample in an appropriate medium; (iv) adding a gelating agent such as to entrap one... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20100120033 - Method for measuring dna methylation: The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on.... Agent: Panitch Schwarze Belisario & Nadel LLP
20100120042 - Method of screening material for improving skin functions: A method of screening a material for improving skin functions includes: (a) treating a skin cell with a candidate material; (b) detecting a change in a relative expression level of membrane-associated protein 17 (MAP17) gene; and (c) selecting a candidate material inducing the change in the expression level of the... Agent: Sughrue Mion, PLLC
20100120039 - Methods and compositions in breast cancer therapy resistance: The present invention is directed to methods and/or compositions regarding a specific mutation in estrogen receptor alpha and their use for identifying resistance to breast cancer therapy and/or treatment therefor. More specifically, the present invention concerns presence or absence of an A908G mutation in an estrogen receptor alpha nucleic acid... Agent: Fulbright & Jaworski, LLP
20100120041 - Methods for detecting and treating kidney disease: A method is provided for diagnosing and monitoring kidney disease or a predisposition to kidney disease, in a subject comprising detecting pVHL, VEGF-A, CXCR4, integrin β-1, PDGF-A, HIF1α and/or TGFβ in a sample from the subject. Screening methods for test agents for inhibiting kidney disease, and therapeutic applications are also... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20100120034 - Methylation analysis of mate pairs: Various embodiments of the present teachings relate to methods for the methylation analysis of nucleic acids. The subject methods include methods that result in the preparation of mate-pair libraries suitable for highly multiplexed DNA sequencing. Embodiments include methods of preparing mate-pair libraries comprising a first tag sequence and a second... Agent: Life Technologies Corporation C/o Intellevate
20100120044 - Modified polynucleotides comprising ribose rings: The invention pertains to different methods employing the use of a polynucleotide comprising ribose rings which carry a modification at the 2′-OH group.... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC
20100120029 - Mutagenesis of aspergillus fungi and genes essential for growth: The present invention is directed to polynucleotides encoding proteins Essential For the Growth (EFG) of filamentous fungi. The invention also deals with namely polypeptides encoded by said polynucleotides, screening assays for identifying compounds capable of inhibiting said EFG proteins activities, pharmaceutical or phytosanitary compositions comprising such compounds.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20100120022 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis: Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623
20100120052 - Orotate transporter encoding marker genes: A recombinant marker gene encoding an orotate transporter polypeptide comprising an amino acid sequence at least 60% identical to SEQ ID NO: 2, a polynucleotide construct comprising at least one copy of the recombinant marker gene, a cell comprising at least one exogenous copy of the marker gene, and a... Agent: Novozymes North America, Inc.
20100120026 - Particulate substrates for improved recovery of microbes: Specially modified microbial growth surfaces improve bacterial recovery or counts when testing for the presence or absence of microbial cells or performing microbial enumerations.... Agent: Richard Aron Osman
20100120028 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 40 to 42 or a combination of at least two of... Agent: Fitzpatrick Cella Harper & Scinto
20100120027 - Prognostic test for early stage non small cell lung cancer (nsclc): The invention provides methods for identifying early stage non-small cell lung cancer (NSCLC) patients who will have a favorable prognosis for the recurrence of lung cancer after surgical resection. The invention is based on the discovery that assessment of chromosomal copy number abnormalities at chromosome 10q23.3 and centromere 10 can... Agent: Vysis, Inc Patent Department
20100120047 - Purification of target cells from complex biological fluids: A method for conducting a molecular analysis on target cells of a complex biological fluid can include the steps of reducing the complexity by selectively depleting at least a portion of non-target cells from the biological fluid, labeling target cells or non-target cells for identification, isolating target cells from non-target... Agent: James P. Broder Roeder & Broder LLP
20100120043 - Sequential analysis of biological samples: Methods for detecting a plurality of targets in a biological sample are provided. The method comprises contacting the biological sample with a plurality of target-binding probes simultaneously to form a plurality of target-bound probes and observing the signals from the target-bound probes sequentially. An associated kit and device for detection... Agent: General Electric Company Global Research
20100120031 - Synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate: The present invention concerns methods of synthesis of trans-tert-butyl-2-aminocylcopentylcarbamate comprising contacting 6-tosyl-6-azabicyclo[3.1.0]hexane with TMSN3 and TBAF to produce 2-azido-N-tosylcyclopentananiine; reducing the 2-azido-N-tosylcyclopentanamine to produce 2-amino-N-tosylcyclopentanamine; contacting the 2-amino-N-tosylcyclopentanamine with di-tert/-butyl dicarbonate to produce tert-butyl-2-(tosylamino)cyclopentylcarbamate; and detosylation of tert-butyl O(tosylamino) cyclopentylcarbamate to produce trans-tert-butyl-2-aminocyclopentylcarbamate. The invention also concerns PNAs comprising residues... Agent: Woodcock Washburn LLP
20100120053 - Tissue analysis and kits therefor: This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. The analysis can be automated or manual. The invention also relates to kits... Agent: Arnold & Porter LLP (24126) Attn:IPDocketing Dept.
20100120032 - Transgenic plant event detection: The present invention relates to detection of materials derived from transgenic plant events. In particular, the invention provides methods, reagents, kits and reference materials for detecting the presence or absence in a sample of genetic material derived from and attributable to select transgenic plant events.... Agent: Amster, Rothstein & Ebenstein LLP
20100120056 - Diagnosis and monitoring of diseases: The present invention relates to the diagnosis and monitoring of diseases and conditions by quantifying markers, including degradation products of disease-associated proteins, such as diketopiperazines composed of the two N-terminal amino acids or the two C-terminal amino acids of such proteins. The methods are useful for diagnosing or monitoring various... Agent: Sheridan Ross PC
20100120058 - Ige antibodies to chimeric or humanized igg therapeutic monoclonal antibodies as a screening test for anaphylaxis: The present invention provides an assay for detecting serum IgE antibody levels to cetuximab and to other proteins. The present invention further provides a method for predicting whether a subject will respond adversely to cetuximab treatment. The present further provides a method for detecting sensitivity to compounds comprising galactose-alpha-1,3-galactose.... Agent: University Of Virginia Patent Foundation
20100120059 - Instrument setup system for a fluorescence analyzer: The present invention reagents and methods for setting up an instruments having a multiplicity of detector channels for analyzing a multiplicity of fluorescent dyes. The present invention is particularly applicable in the field of flow cytometry.... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20100120057 - Methods of reducing non-specific interaction in metal nanoparticle assays: The present invention discloses methods of reducing non-specific interactions of interfering species present in a sample in metallic nanoparticle-based assays, thereby increasing the sensitivity of these assays. In particular, the methods entail neutralizing the chemical reactivity of functional groups present in interfering species by addition of a neutralizing agent, such... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20100120054 - Monomeric and polymeric linkers useful for conjugating biological molecules and other substances: The present invention concerns monomeric or polymeric linker molecules useful in biological and chemical applications, their synthesis, and the synthesis and use of derivatives of the linkers conjugated to a variety of detectable labels and other substances. The linkers may be used, for example, in conjunction with fluorescent labels, nucleic... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20100120055 - Tyrosine phosphorylation sites: The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel
20100120063 - Gpcr arrestin assays: Sensitive assays for candidate compounds affecting GPCR activity are provided using a cell containing fusion proteins comprising a first fusion protein comprising (a) a target GPCR fused to a small fragment of β-galactosidase through a linker comprising a phosphorylation site or (b) a GPCR or a protein of interest, where... Agent: Peters Verny , L.L.P.
20100120060 - Method for determining molecules or molecule parts in biological samples: The invention relates to a method for determining molecules, molecule groups, and/or molecule parts in biological samples. The method includes spiking the sample at least once with at least one light emitting marker and measuring the light emission of the marker. Herein, it is intended that the light emission inherent... Agent: Latimer & MayberryIPLaw, LLP
20100120061 - Rapid immunochromatographic detection by amplification of the colloidal gold signal: The present invention relates to a rapid immunochromatographic test device suitable to detect an antibody and/or antigen in a sample, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the device.... Agent: Patent Central LLC Stephan A. Pendorf
20100120062 - Rhizome viability determination method: A method of determining the viability of a rhizome comprises the sequential steps of: (a) sampling material from the rhizome; (b) contacting material sampled in step (a) with an effective amount of a formulation comprising a first viability indicator; and (c) observing the action of the first viability indicator on... Agent: Renner Kenner Greive Bobak Taylor & Weber
20100120068 - G-protein-conjugated receptor having altered ligand affinity, and use thereof: A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. Furthermore, agonists for or antagonists against the modified GPCR are screened using a transformant in which the modified GPCR has... Agent: Edwards Angell Palmer & Dodge LLP
20100120069 - Multipotent/pluripotent cells and methods: Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.... Agent: Wilson, Sonsini, Goodrich & Rosati
20100120070 - Precise efficacy assay methods for active agents including chemotherapeutic agents: An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying. One particularly... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20100120071 - Detection and measurement of blood-feeding activity: This invention provides compositions and methods for detection of hematophagous ectoparasitic activity in an enclosure or area. The compositions comprise a reagent or reagents which are reactive against antigens or markers as they appear in the excrement or other ectoparasitic materials. Such markers or antigens may be produced by the... Agent: Hodgson Russ LLP The Guaranty Building
20100120072 - Detection of elevated levels of her-2/neu protein from non-isolated circulating cancer cells and treatment: The expression of Her-2/neu protein on circulating cancer cells in a sample of blood or peripheral blood mononuclear cells (PBMCs) is detected by performing a sensitive Her-2/neu immunoassay. There is no need to isolate the cancer cells before performing the immunoassay. A positive result indicates the expression of Her-2/neu on... Agent: Wellstat Management Company. LLC
20100120073 - Methods and devices for detecting organisms causing urinary tract infections: The invention provides for devices and methods for detecting an organism causing a urinary tract infection. In a preferred embodiment, detecting the organism causing a urinary tract infection follows a preliminary indication of a urinary tract infection by a urinary monitoring device to monitor for the presence or absence of... Agent: Sherrill Law Offices
20100120064 - Antibody specific to intact human autotaxin, method of screening the same and method and reagent for examining malignant lymphoma by assaying autotaxin: A screening method is provided for antibody specifically recognizing naturally-occurring form of human autotaxin in a state in which it is present in the body without being denatured, comprising the steps of: binding a binding factor capable of capturing a candidate antibody of the antibody to a solid phase; binding... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100120066 - Method for detecting interactions between two and more biological macromolecules: Methods for detecting interactions of biomolecules include (a) preparing a cell comprising (i) a first construct comprising a bait, a first labeling material and a translocation module; and (ii) a second construct comprising a prey and a second labeling material; (b) detecting the distribution of the first construct and the... Agent: Edwards Angell Palmer & Dodge LLP
20100120065 - Method for determining endoglycosidase (heparanase) enzyme activity: The present invention provides a method for determining endoglycosidase activity, and in particular of the heparanase type, in a sample, and also a method for detecting compounds that modulate the activity of endoglycosidases and in particular endoglycosidases of the heparanase type.... Agent: Knobbe Martens Olson & Bear LLP
20100120067 - H. meleagridis assay: Methods for the detection or quantification of antibodies against H. meleagridis. Such methods generally comprise providing a surface with immobilized antibodies against H. meleagridis and H. meleagridis antigens immobilized on said antibodies, and/or with isolated H. meleagridis antigens, contacting a sample which potentially comprises antibodies against H. meleagridis, and detecting... Agent: Fulbright & Jaworski L.L.P.
20100120074 - Methods and kits for detection of cancer metastasis: t
20100120075 - Composition and a method for suppressing the luminescence intensity decline in a luciferin-luciferase reaction: The invention relates to compositions and methods for suppressing the luminescence intensity decline that occurs as the reaction between Cypridina luciferase and luciferin proceeds.... Agent: Wenderoth, Lind & Ponack, L.L.P.
20100120080 - Cancer diagnosis using ki-67: The present invention provides methods and compositions for detection, diagnosis, prognosis, monitoring treatment and monitoring progression of cancer by detecting the level of Ki-67 protein in an individual.... Agent: Foley & Lardner LLP
20100120081 - High sensitivity parameters for the detection of vitamin b12 and/or folate deficiencies and methods of use: Described herein are high sensitivity parameters useful for the detection of vitamin B12 and/or folate deficiencies. Methods of determining susceptibility for vitamin B12 and/or folate deficiency in a subject are also provided. Methods of determining the progress and assessment of treatment of these deficiencies are provided.... Agent: Howson & Howson LLP / Beckman Coulter, Inc.
20100120076 - Method for antenatal estimation of risk of aneuploidy: The present invention relates to a system and a method for evaluating the risk of carrying a fetus with genetic anomalies such as aneuploidy and in particular, to such a system and method where a screening system and method is provided to identify fetus' having trisomy-21 (Down's syndrome) with the... Agent: Nixon & Vanderhye, PC
20100120077 - Microfluidic particle-analysis systems: The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or analysis of particles, such as cells, viruses, organelles, beads, and/or vesicles. The invention also... Agent: Townsend And Townsend And Crew, LLP
20100120082 - Optimization of process variables in oxygen enriched fermentors through process controls: Methods and systems are provided for controlling the addition of oxygen in fermentations to achieve a desired oxygen consumption and substrate yield in fermentation cell cultures. In one aspect, the invention provides a method for regulating the addition of oxygen (O2) to a fermentor during a fermentation process, comprising measuring... Agent: Air Liquide Intellectual Property
20100120079 - Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies: The invention provides a method for effecting the trans-differentiation of a somatic cell, i.e., the conversion of a somatic cell of one cell type into a somatic cell of a different cell type. The method is practiced by culturing a somatic cell in the presence of at least one agent... Agent: Hunton & Williams LLP Intellectual Property Department
20100120078 - Urine stabilization system: The present disclosure relates, according to some embodiments, to a method of stabilizing a molecule (e.g., a biomolecule) in a bodily fluid comprising: (1) providing a stabilizing solution comprising: (a) an amount of a divalent metal chelator selected from the group consisting of ethylenediaminetetraacetic acid (EDTA), (ethylenebis(oxyethylenenitrilo))tetraacetic acid (EGTA), and... Agent: King & Spalding LLP
20100120083 - Disposable cassette and method of use for blood analysis on blood analyzer: A disposable cassette for blood analysis includes a housing having an upper panel and a sampling section having a filling inlet; at least one pair of chambers in a form of depression of the upper panel of the housing and sealed by a diaphragm; portions of the diaphragm over the... Agent: Latimer & MayberryIPLaw, LLP
20100120085 - Method for separation, characterization and/or identification of microorganisms using mass spectrometry: The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be... Agent: Biomerieux, Inc.
20100120084 - Reaction medium for identifying/detecting microorganisms: The present invention relates to a reaction medium for identifying/detecting microorganisms, that comprises at least one active molecule encapsulated in a cyclodextrin.... Agent: Oliff & Berridge, PLC
20100120087 - Enzymatic or organic catalytic chemical reactions: In an aspect, a perturbation is applied to a system comprising an enzymatic chemical reaction and/or an organic catalytic chemical reaction with the perturbation being non-directional (average of the force applied by the perturbation being zero) with respect to a variable of the system. A directional effect is caused with... Agent: Fish & Richardson PC
20100120089 - A novel vector and expression cell line for mass production of recombinant protein and a process of producing recombinant protein using same: Disclosed herein is an inducible high-expression cassette comprising a dihydrofolate reductase (DHFR) promoter from which GC-rich repeat sequences are partially or entirely removed, the cassette capable of more effectively improving a gene amplification system. Also disclosed are an expression vector comprising the inducible expression cassette and optionally a gene encoding... Agent: Seed Intellectual Property Law Group PLLC
20100120090 - Mammalian expression vector puhab: The present invention relates to the construction and utilization of a new mammalian expression vector that contains a unique multiple cloning site (MCS), designated pUHAB. The pUHAB vector comprises a high copy replication origin (ColE1), a drug resistance gene (TK-Hygromycin), and a human cytomegalovirus promoter operably associated with a unique... Agent: Merck Patent Department (k-6-1, 1990)
20100120088 - Mutant 6-phosphogluconate dehydrogenase: The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to the genus Corynebacterium, said modification being substitution of the amino acid residue(s) at the position(s) corresponding to the 158th and/or the 361st amino acid(s)... Agent: Antonelli, Terry, Stout & Kraus, LLP
20100120091 - Subtilase variants: The present invention relates to novel subtilase variants exhibiting improvements relative to the parent subtilase in one or more properties including: wash performance, thermal stability, storage stability or catalytic activity. The variants of the invention are suitable for use in e.g., cleaning or detergent compositions, such as laundry detergent compositions... Agent: Novozymes North America, Inc.
20100120092 - Recombinant proteins and virus like particles comprising l and s polypeptides of avian hepadnaviridae and methods, nucleic acid constructs, vectors and host cells for producing same: The specification discloses chimeric or recombinant virus-like particles comprising (i) S polypeptide of an avian hepadnavirus and (ii) a chimeric fusion protein comprising a polypeptide of interest covalently attached to a particle-associating portion of L polypeptide of an avian hepadnavirus, wherein the polypeptide of interest comprises a transmembrane domain or... Agent: Scully Scott Murphy & Presser, PC
20100120093 - Method of producing serum-free insulin-free factor vii: The invention provides methods and compositions for the serum-free, insulin-free production of recombinant Factor VII.... Agent: Mcandrews Held & Malloy, Ltd
20100120094 - Factor viii polypeptide titers in cell cultures: The invention relates to a method for the production of a Factor VIII polypeptide, the method comprising the steps of a) culturing a mammalian cell expressing a Factor VIII polypeptide under conditions for expression of said Factor VIII polypeptide, said culturing conditions involving a cell culture medium comprising a C2-domain... Agent: Novo Nordisk, Inc. Intellectual Property Department
20100120095 - Electromagnetic bioaccelerator: The present invention relates to an electromagnetic bioaccelerator for obtaining biomass by simulating environmental marine conditions, comprising at least the following elements: octagonal biomass converters (1), seawater reserve tanks (3), particle filters (4), UV light filters (5), feedback and mixture tanks (6), pressurization feed tanks (8), manometers (9), pressure controllers... Agent: Ladas & Parry LLP
20100120096 - Method for producing lacto-n-biose i and galacto-n-biose: e
20100120097 - Methods and compositions for nucleic acid sequencing: The present invention includes novel compositions and method for nucleic acid sequencing. The methods and compositions permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number of different oligonucleotides with superior output and quality.... Agent: Chalker Flores, LLP
20100120099 - Device for the carrying out of chemical or biological reactions: e
20100120100 - Device for the carrying out of chemical or biological reactions: An interactive radio network enables users to interact with the content of a radio broadcast, including commercials or messages, and to selectively save, store, review, fast forward, rewind, pause, forward, and respond to the radio programs and/or the commercials. The interactive radio network provides a widespread, international, and economical access... Agent: Life Technologies Corporation C/o Intellevate
20100120098 - Transposon end compositions and methods for modifying nucleic acids: The present invention provides methods, compositions and kits for using a transposase and a transposon end for generating extensive fragmentation and 5′-tagging of double-stranded target DNA in vitro, then using a DNA polymerase for generating 5′- and 3′-tagged single-stranded DNA fragments without performing a PCR amplification reaction, wherein the first... Agent: Casimir Jones, S.c.
20100120101 - Reaction chamber: A chamber in which an agent, like genomic DNA, may be harvested and optionally manipulated rapidly (e.g., on the order of a few hours), without shearing or fragmentation.... Agent: Wolf Greenfield & Sacks, P.C.
20100120102 - Enantioselective epoxide hydlrolase and method for preparing and enantiopure epoxide using the same: The present invention relates to enantioselective epoxide hydrolase proteins isolated from marine microorganisms, which has high enantioselectivity to various epoxide substrates, and a method of preparing the epoxides with high enantio-purity by using the epoxide hydrolases. The enantioselective hydrolase protein of the present invention can be applied for the preparation... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c
20100120103 - Recombinant production docosahexaenoic acid (dha) in yeast: The present invention relates to a specifically novel recombinant method of production of the omega-3 fatty acid, Docosahexaenoic acid by a potentially safe recombinant organism Saccharomyces cerevisiae. The invention describes the process of bioconversion of oleic acid to docosahexaenoic acid through a series of enzymatic conversions facilitated through the cloning... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100120104 - Biological and chemical process utilizing chemoautotrophic microorganisms for the chemosythetic fixation of carbon dioxide and/or other inorganic carbon sources into organic compounds, and the generation of additional useful products: The invention described herein presents compositions and methods for a multistep biological and chemical process for the capture and conversion of carbon dioxide and/or other forms of inorganic carbon into organic chemicals including biofuels or other useful industrial, chemical, pharmaceutical, or biomass products. One or more process steps in the... Agent: John Reed
20100120105 - Carbon pathway optimized production hosts for the production of isobutanol: A microbial host cell is provided for the production of isobutanol. Carbon flux in the cell is optimized through the Entner-Doudoroff pathway.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20100120106 - Process for producing lower alkyl alcohols from cellulosic biomass using microorganisms: At least one isolated microorganism, which converts at least 10% by weight, and preferably 50% by weight, of cellulosic biomass to a lower alkyl alcohol by direct digestion, and which produces at least 4% by volume of the lower alkyl alcohol in an aqueous-based digestion medium.... Agent: The Nath Law Group
20100120107 - Production of biofuel and protein from a raw material: The present invention relates to a method for providing an isolated biofuel and a purified protein product from a raw material suitable for the production of the biofuel or a derivative of said raw material. The method comprises the steps of: (i) subjecting the raw material or a derivative of... Agent: Foley And Lardner LLP Suite 500
20100120109 - High dry matter sweet potatoes for fuel ethanol, green energy, chips and fries: A variety type of sweetpotato, Ipomoea batatas, that was grown in such a manner to maximize the tonnage of storage roots produced. These types of sweetpotato can accumulate from 28% to 40% dry matter in the root which is mostly carbohydrate. By combining high levels of carbohydrate (mostly starch and... Agent: Barnes & Thornburg LLP
20100120108 - Polypeptides having glucoamylase activity and polynucleotides encoding same: The present invention relates to polypeptides having glucoamylase activity and isolated polynucleotides encoding said polypeptides preferably derived from a strain of Peniphora rufomarginata. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. The invention... Agent: Novozymes North America, Inc.
20100120110 - Cytochrome p450s and uses thereof: The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic... Agent: Catalyst Law Group, Apc
20100120111 - Method of producing hydrocarbon biofuels using genetically modified seaweed: A method of producing hydrocarbon biofuels using genetically modified seaweed by inserting genes from high hydrocarbon producing micro algae into high growth seaweed species. In an embodiment of the present invention, Botryococcus braunii (BB) a green micro algae that produces large amounts of aliphatic hydrocarbon molecules is used as a... Agent: Greer, Burns & Crain
20100120112 - Process of improved semi-static composting for the production of a humectant substrate of low density of use thereof in nurseries and greenhouses: Another objective is to provide, in 8 weeks, a material without pathogenic microorganisms nor weeds, with low density (<0.4 g/ml), high porosity (110%), and high water retention (>90%), applicable as a substrate in horticulture and forestal production in nurseries and greenhouses; or as an humectant and soil-improving agent in agricultural... Agent: Patent Docket Department Armstrong Teasdale LLP
20100120113 - Apparatus and method for micromanipulation of microscale objects using laser light delivered through a single optical fiber and axicon lens: A single optical fiber having a distal end is optically coupled to the laser and distilling terminated with an axicon lens optically coupled to the single optical fiber to form a microscopic distal tip to provide a spatially shaped elongated laser focused spot for microprocessing and/or microdissection of a microscale... Agent: Law Offices Of Daniel L. Dawes Dawes Patent Law Group
20100120114 - Air cleaning filter comprising formaldehyde dehydrogenase and process for producing the same: Disclosed are a formaldehyde dehydrogenase-containing air cleaning filter, and a method for manufacturing the same. The method includes coating a carrier with formaldehyde dehydrogenase to immobilize the formaldehyde dehydrogenase thereon. Alternatively, the method includes coating a carrier with a coating solution, and drying the carrier, wherein the coating solution comprises... Agent: Mckenna Long & Aldridge LLP
20100120115 - Compositions and methods for making and using laminin nanofibers: The present invention encompasses methodologies and parameters for the formation of nanofibrous (to microfibrous) laminin via electrospinning. The present application discloses conditions and appropriate parameters to synthesize laminin fibers from a diameter of about 10 nM to a diameter of over 1,000 nM via electrospinning.... Agent: University Of Virginia Patent Foundation
20100120116 - Nanopatterned biopolymer optical device and method of manufacturing the same: A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a... Agent: David S. Resnick
20100120117 - Polymer coating of cells: Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.... Agent: Knobbe Martens Olson & Bear LLP
20100120118 - Mrna interferase from myxococcus xanthus: A deployment of a toxin gene for developmental programmed cell death in bacteria is described. M. xanthus is demonstrated to have a solitary mazF gene that lacks a cotranscribed antitoxin gene. Deletion of mazF results in elimination of the obligatory cell death during development causing dramatic reduction in spore formation.... Agent: Patent Docket Administrator Lowenstein Sandler PC
20100120119 - Method of producing liquid koji: An object of the present invention is to provide a method of producing liquid koji having high enzymatic activity by optimizing composition of liquid medium for the liquid koji. In particular, the present invention provides a method of producing liquid koji having enhanced enzymatic activity, the method comprising culturing white... Agent: Sughrue Mion, PLLC
20100120120 - Haemocoagulase: The present invention provides a venene haemocoagulase gene and its expression for the functional protein. The haemocoagulase gene of the present invention has a nucleotide sequence shown by the sequence list SEQ ID NO: 1 or the mutated nucleotide sequence formed by replacement, depletion, or addition of one or more... Agent: Workman Nydegger 1000 Eagle Gate Tower
20100120121 - Process for typing of hcv isolates: e
20100120122 - Targeted gene delivery for dendritic cell vaccination: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions,... Agent: Knobbe Martens Olson & Bear LLP
20100120123 - Accelerated heat generation in heap bioleaching by controlled carbon dioxide addition: A microbial leaching process is carried out on a heap of particulate chalcopyrite ore by adding carbon dioxide to an air stream directed into the heap at least when the heap is at mesophilic temperatures, to stimulate growth, and to achieve a sufficiently high concentration, of mesophilic microbial strains in... Agent: Brinks Hofer Gilson & Lione
20100120125 - Bacterial biomineralization of contaminants: The various embodiments of the present disclosure relate generally to bacterial biomineralization of contaminants and, more particularly, to methods, systems and compositions for the biomineralization of soil and water contaminants, such as metals and radionuclides. In one aspect of the present invention, a method for the in situ biomineralization of... Agent: Troutman Sanders LLP 5200 Bank Of America Plaza
20100120124 - Systems, methods and microrganisms for antibody production with type iii secretion system: Exemplary embodiments disclosed herein include a microorganism that produces, secretes and injects recombinant antibodies into eukaryote cells said the described microorganisms can be used to prepare pharmaceutical compositions for the treatment of human or veterinary diseases.... Agent: Ip Patent Docketing K&l Gates LLP
20100120126 - Microorganisms producing dipeptides and process for producing dipeptide using the microorganisms: Microorganisms in which the activities of one or more kinds of peptidases and one or more kinds of proteins having peptide-transporting activity are reduced or lost and which have the ability to produce a dipeptide. Also, microorganisms in which the activities of three or more kinds of peptidases are reduced... Agent: Fitzpatrick Cella Harper & Scinto
20100120127 - Method for removing bacteria from a fermentation broth: The invention relates to method for the stepwise removal of bacteria from a fermentation broth. According to said method, the bacteria in the fermentation broth are mixed with a retention promoter mixture in a first process step and the pretreated bacteria are removed by precoat filtration in a second process... Agent: Michael J. Striker
20100120128 - Eco-engineering for systematic carbon mitigation: To deal with climate change, the present invention provides an eco-engineering for systematic carbon mitigation, in particular, a comprehensive carbon management system with a group of Stabilized Functional Carbons (SFCs) to reduce the total amount of carbons in atmosphere. SFCs are sourced and manufactured from the carbon-fixed biomass by one... Agent: Ning Qian
20100120129 - Apparatus for and method of processing biological samples: The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food... Agent: Life Technologies Corporation C/o Intellevate
20100120130 - Droplet actuator with droplet retention structures: The present invention is directed to droplet actuators with droplet retention structures, and methods related thereto. In an exemplary embodiment, the invention provides a droplet actuator with one or more substrates arranged to form a droplet operations gap comprising gap-facing surfaces; droplet operations electrodes configured to conduct droplet operations in... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.
20100120131 - Reagent delivery system: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP
20100120132 - Bioassays by direct optical detection of nanoparticles: Embodiments of the invention relate to detecting biological molecules with ultra-sensitivity and convenience. The embodiments are especially directed to utilizing nanoparticles as tags and identifying the tags using dark-field microscopy. The probes containing the nanoparticles can be used in solution or attached to a substrate.... Agent: Pillsbury Winthrop Shaw Pittman LLP (intel)
20100120133 - Separation device for use in the separation, characterization and/or identification of microorganisms: The present invention is directed to a separation device or container that can be used in the separation, isolation or pelleting of microorganisms from a test samples known to contain or suspected of containing said microorganisms. Subsequently, the separated, isolated or pelleted microorganism sample can undergo one or more interrogation... Agent: Biomerieux, Inc.
20100120134 - Micro-organism production apparatus and system: A micro-organism production system having at least one micro-organism growth unit for maintaining therein micro-organisms in solution. Upon the receipt of a predetermined amount of live organisms, liquid and nutrients within the at least one micro-organism growth unit and the application of radiation thereto, the system produces the rapid growth... Agent: Burns & Levinson, LLP
20100120135 - Apparatus for growing biological mass: An apparatus for growing biological mass has a container for accommodating a biological mass in liquid to be grown in presence of light, a plurality of light sources in an interior of the container, a first movable plate which has passages for the light sources and which is reciprocatingly movable... Agent: Iiya Zborovsky
20100120137 - Apparatus for growing biological mass: An apparatus for growing biological mass has a container for accommodating and growing a biological mass, a unit for supplying liquid in the container, a unit for supplying CO2 in the container, a unit for supplying a feedstock in the container, and a cavitating device arranged so that a liquid... Agent: Llya Zborovsky
20100120136 - Bioreactor for cell and tissue culture: The present invention provides a bioreacto 1r for incubation of cell cultures, tissue biopsies, cell clusters, tissue-like structures, ‘prototissues’ or similar samples. The bioreactor is generally adapted for rotation for use in microgravity conditions and equipped with an incubation cavity having a small internal fluid volume, generally less than 1... Agent: Merchant & Gould PC
20100120138 - Enhanced feedstock for use with micro-refineries: An ethanol production system includes a feedstock distributor and a micro-refinery. The feedstock distributor can pre-ferment and pre-distill the feedstock so that the ethanol content can be between 15% and 50%. This processing can improve the ethanol production efficiency because less waste material is transported from the distributor to the... Agent: Dergosits & Noah LLP
20100120139 - Incubation apparatus: An incubation apparatus is provided to incubate culture targets such as cells, embryos or microorganisms in an incubation chamber. The incubation apparatus is capable of inexpensively, highly accurately and automatically calibrating a gas concentration sensor. The incubation apparatus includes a gas concentration sensor 42 which detects a gas concentration in... Agent: Kratz, Quintos & Hanson, LLP
20100120140 - Targeted gene delivery for dendritic cell vaccination: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions,... Agent: Knobbe Martens Olson & Bear LLP
20100120141 - Screening methods for compounds that modulate the activity of g-protein coupled receptors: The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eucaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or... Agent: Propat, L.L.C. Attn: Klaus Schweitzer
20100120142 - Culture of human embryonic cells: The invention relates to a method for culturing human embryonic stem cells (hESCs) with a lectin. The invention relates also to the use of a lectin in a method for culturing human embryonic stem cells (hESCs) and a culture medium composition containing a lectin.... Agent: Birch Stewart Kolasch & Birch
20100120143 - Induction of apoptosis and cell growth inhibition by protein 4.33: There is disclosed an isolated cDNA sequence (SEQ ID NO:1) encoding a P4.33 polypeptide and comprising a coding region (SEQ ID NO:2) of the sequence described in SEQ ID NO:1, or a sequence having at least 90% homology with the coding region of SEQ ID NO:1. The P4.33 polypeptide functions... Agent: Davis Wright Tremaine, LLP/seattle
20100120144 - Method of culturing cells: A blood component such as platelets is concentrated. The concentrate, such as platelet-rich plasma, is used in a cell culture medium to grow and proliferate cells. The cells may be from the same person from which the blood concentrate is obtained. The cells grown in the culture medium may be... Agent: Knobbe Martens Olson & Bear LLP
20100120145 - Three-dimensional biocompatible skeleton structure containing nanoparticles: The invention relates to a cell culture system comprising a three-dimensional, biocompatible frame structure and biocompatible nanoparticles, a method for the cultivation of cells, and the preparation of cells or cell products and tissues per se by means of such a cell culture system.... Agent: Harness, Dickey & Pierce, P.L.C
20100120146 - Activator of signal transduction pathway: The present invention is directed to providing the activator of the integrin signaling in neural stem cells or neural progenitors and the method for using the same. The activator of the integrin signaling comprises galectin-1 and can be used as a regulator that regulates maintenance, survival, or differentiation of a... Agent: Clark & Elbing LLP
20100120147 - Antagonist of ligands and uses thereof: The invention provides multivalent ligand binging agents (traps) for members of the TGF-β superfamily and polypeptide linkers and methods for making and using such constructs. In an embodiment of the invention there is provided a multivalent binding agent with affinity for a member of the TGF-β superfamily, said agent comprising... Agent: National Research Council Of Canada
20100120148 - Method for decomposing biological tissue: A biological tissue is decomposed in a short time, and cells are obtained at a high yield without interfering with the health of cells obtained through the decomposition. There is provided a method for decomposing biological tissue which decomposes a biological tissue under an action of a digestive enzyme, comprising:... Agent: Scully Scott Murphy & Presser, PC
20100120149 - Cell aggregate-hydrogel-polymer scaffold complex for cartilage regeneration, method for the preparation thereof and composition comprising the same: The present invention relates to a cell aggregate-hydrogel-polymer scaffold complex useful for cartilage regeneration which has a structure in which cell aggregates of differentiated chondrocytes are evenly dispersed in a hydrogel matrix, and the resulting hydrogel matrix is immobilized onto the surface of a polymer scaffold while filling up the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100120150 - Method for preparing serum and serum preparation apparatus: A method for preparing serum and a serum preparation apparatus is provided that can give a large amount of serum with high culture efficiency regardless of freshness of blood used. In a method for preparing serum from blood containing at least platelets, a platelet processing step is provided in which... Agent: Muncy, Geissler, Olds & Lowe, PLLC
20100120151 - Molecular markers of plant embryogenesis: The present invention relates generally to a molecular marker for a plant physiological process and more particularly for plant embryogenesis. The molecular marker is, in one form, a genetic sequence from a monocot plant such as but not limited to oil-palm plants. In another form, the molecular marker is a... Agent: Frank S. Digiglio Scully, Scott, Murphy & Presser
20100120155 - Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof: The embodiments disclosed herein relate to the construction of fully-deleted Adenovirus-based gene delivery vectors packaged without helper Adenovirus, and more particularly to their use in gene therapy for gene and protein expression, vaccine development, and immunosuppressive therapy for allogeneic transplantation. In an embodiment, a method for propagating an adenoviral vector... Agent: Greenberg Traurig, LLP
20100120154 - Method for homologous recombination: growing the cells to obtain transformed progeny cells having a DNA molecule from the first set recombined with a DNA molecule from the second set into a DNA molecule comprising a functional replacement sequence and having the target sequence replaced by the functional replacement sequence.... Agent: Nixon & Vanderhye, PC
20100120152 - Methods for expression of transgenes: The present invention relates to compositions and methods for increasing long term expression in vitro and in vivo, comprising sequences and gene expression cassettes that increase expression of genes to which they are operably linked.... Agent: Roche Madison Inc.
20100120153 - N-glycosylation mutant of melanoma differentiation associated gene-7: The present invention relates to MDA-7 variant proteins which are deficient in or lack glycosylation. It is based, at least in part, on the results of experiments which have demonstrated that such variants are functionally equivalent to wild-type MDA-7 protein. Such proteins may be more easily produced large-scale than the... Agent: Baker Botts L.L.P.05/06/2010 > patent applications in patent subcategories. archived by USPTO category
20100112542 - Method and apparatus for controlling air pressure in an organ or tissue container: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow... Agent: Oliff & Berridge, PLC
20100112543 - Processing soft tissue, methods and compositions related thereto: In certain embodiments, the present invention relates to a process for preparing skin removed from a human donor, including a living human donor, and removing cellular components and forming a decellular matrix having as major components collagens and elastins while disinfecting the tissue. In other embodiments, the present invention relates... Agent: Sandra Kuzmich, Ph.d., Esq. C/o Frommer Lawrence & Haug LLP
20100112544 - Modified routes of lipid metabolism, measuring oxidized ldl after fat loading: The present invention relates to monitoring of lipid metabolism and is, particularly, directed to a test for estimating the individual susceptibility of a subject to the effect of oxidized dietary lipids. A high calorie and high fat meal were given to subjects and postprandial levels of oxidized low-density lipoproteins (LDL)... Agent: Birch Stewart Kolasch & Birch
20100112548 - Kit for detecting non-pathogenic or pathogenic influenza a subtype h5 virus: Current methods for detecting influenza A subtype H5 virus, for example cell culture, haemagglutination-inhibition, fluorescent antibody and enzyme immunoassay, and reverse transcriptase polymerase chain reaction (RT-PCR) may have the disadvantages of low sensitivity and low specificity. Furthermore, such methods are relatively difficult to use, and may not be suitable for... Agent: Heslin Rothenberg Farley & Mesiti PC
20100112547 - Methods and compositions for diagnosis and treatment of influenza: The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the... Agent: Townsend And Townsend And Crew, LLP
20100112550 - Microfluidic assay for characterization of the leukocyte adhesion cascade: An apparatus and method for identifying and screening for agents affecting the leukocyte adhesion cascade (LAC) encompassing rolling, adhesion and migration comprises an optically clear, plastic microfluidic chip comprising flow channels with diameters in the range of 10-500 μm. The flow channels are coated with endothelial cells and at least... Agent: Tomas Friend, LLC
20100112549 - Microorganism detection method and apparatus: Embodiments of the present invention relate to selective organism detection, and, more particularly to recombinant bacteriophages and the use of such recombinant bacteriophages to detect target bacteria and to detect specific nucleic acid sequences within said target bacteria thus allowing for the detection of phenotypic characteristics of said bacteria such... Agent: Bond, Schoeneck & King, PLLC
20100112546 - Nanoscale sensors: Various aspects of the present invention generally relate to nanoscale wire devices and methods for use in determining analytes suspected to be present in a sample, and systems and methods of immobilizing entities such as reaction entities relative to nanoscale wires. In one aspect, a nucleic acid, such as DNA,... Agent: Harvard University & Medical School C/o Wolf, Greenfield & Sacks, P.C.
20100112545 - Trans-1,2-diphenylethlene derivatives and nanosensors made therefrom: Novel trans-1,2-diphenylethylene derivatives are synthesized which can be used to form nanoparticles-monomer-nanomolecule-receptor nanosensors. These trans-1,2-diphenyl-ethylene derivatives are soluble in both water and organic solvents, highly fluorescent and can be synthesized in high yields. The trans-1,2-diphenylethylene derivatives are bonded to a nanoparticle, a nanomolecule bonded to the derivative and a receptor... Agent: Flynn Thiel Boutell & Tanis, P.C.
20100112589 - Allele-allele interactions of mthfr gene variants, and uses thereof in predicting disease risk: The invention provides methods of predicting risk of developing a hyper-homocysteine-associated disease in a subject, based on genotyping of the methylenetetrahydrofolate reductase (MTHFR) gene, wherein the risk varies depending on whether the 677T polymorphism and the 1298C polymorphism are present in a cis configuration within a MTHFR gene or not.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20100112577 - Apparatus and methods for efficient processing of biological samples on slides: Methods for treating biological samples on microscope slides are set forth. One aspect of the invention is the use of predried reagents in wells on trays onto which the slides are placed, especially the use of predried reagents which dissolve sequentially. Yet another aspect of the invention is the use... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100112551 - Approaches to identifying mutations associated with hereditary nonpolyposis colorectal cancer: The present invention relates to the field of genetic screening. More specifically, the described embodiments concern methods to screen multiple samples, in a single assay, for the presence or absence of mutations or polymorphisms in a plurality of genes. Approaches to screen for the presence or absence of mutations that... Agent: Biotech Beach Law Group , PC
20100112595 - Bisulfite conversion reagent: Disclosed, among other things, are packaged bisulfite solutions comprising bisulfite reagent in an oxygen-impermeable container and methods.... Agent: Life Technologies Corporation C/o Intellevate
20100112583 - Blood diagnosis method for dialysis patient and dialysis machine: the method including a step for collecting a blood sample from a dialysis patient before and after dialysis; and a step for making a diagnosis regarding the collected blood sample based on a biomarker, wherein the biomarker is identified in advance based on the correlation between the urea clear space... Agent: Sughrue Mion, PLLC
20100112571 - Compositions and methods for detecting mutations in jak2 nucleic acid: The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides compositions and methods useful for diagnosing hematopoietic diseases including, for example, myeloproliferative diseases. The invention also provides compositions and methods useful for determining a prognosis of an individual... Agent: Foley & Lardner LLP
20100112572 - Compositions, methods, and kits for fabricating coded molecular tags: The teachings herein generally relates to probes comprising fabricated coded molecular tags for detecting analytes. The teachings also relate to compositions, methods, and kits for fabricating coded molecular tags comprising a multiplicity or reporter groups in an ordered pattern.... Agent: Life Technologies Corporation C/o Intellevate
20100112584 - Cyanine compounds and their use in staining biological samples: Cyanine compounds having the general formula I for staining biological samples, wherein R1, R2, X, Y, A1 and A2 are as defined in the specification. These kinds of compounds may show good light illumination stability, have a maximum absorption peak around 640 nm that may not change as a function... Agent: Stoel Rives LLP - Slc
20100112590 - Diagnosing fetal chromosomal aneuploidy using genomic sequencing with enrichment: Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome... Agent: Townsend And Townsend And Crew, LLP
20100112586 - Diagnosis of fetal abnormalities by comparative genomic hybridization analysis: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves performing comparative genomic hybridization (CGH) analysis when fetal cells are present in a... Agent: Wilson, Sonsini, Goodrich & Rosati
20100112561 - Fluorescent nucleoside analogues: Briefly described, embodiments of the present disclosure include novel fluorescent nucleoside analogs (fNAs) including a fluorescent nucleobase, selected from a purine and a pyrimidine base or analog thereof, and a modified sugar moiety that differs in structure from a sugar moiety of a naturally occurring nucleoside. In embodiments, the fNAs... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP
20100112576 - Focusing chamber: Aspects of the invention relate to devices and methods of use thereof for concentrating, positioning and/or manipulating agents within a fluid, including but not limited to genomic DNA.... Agent: Wolf Greenfield & Sacks, P.C.
20100112582 - Gene encoding labyrinthin, a marker for cancer: A cDNA molecule that encodes a protein designated Labyrinthin (Lab) isolated and its nucleotide sequence is determined. The protein, or peptides derived from the protein, are markers useful to define novel classes of cancers. Diagnostic assays for these cancers use antibodies to Lab or nucleotide probes that hybridize with the... Agent: Wilson, Sonsini, Goodrich & Rosati
20100112570 - Genetic markers for weight management and methods of use thereof: This application relates to methods and tests that allow for the establishment of personalized weight-loss programs for a subject based upon the subject's metabolic genotype in key metabolic genes. Kits and methods are disclosed for determining a subject's metabolic genotype, which may be used to select an appropriate therapeutic/dietary regimen... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100112580 - Means and methods for haplotyping mhc-drb loci in mammals and uses thereof: The invention relates to the typing of MHC-DRB loci in mammals. In particular, the invention provides a typing procedure for the mammalian DRB region that allows an easy, economical, high resolution, fast and accurate haplotyping protocol. The invention further provides the use of said typing procedure in genetic applications, and... Agent: Hoffmann & Baron, LLP
20100112560 - Mechanism to signal receptor-ligand interactions with luminescent quantum dots: Semiconductor quantum dots are becoming valuable analytical tools for use in biomedical applications. Indeed, their unique properties offer the opportunity to design luminescent probes for imaging and sensing with unprecedented performance. In this context, we have identified operating principles to transduce supramolecular association of complementary receptor-ligand binding pairs into enhancement... Agent: Nixon & Vanderhye, PC
20100112579 - Method and device for the detection of genetic material by polymerase chain reaction: The present invention relates to a method and a portable device to detect a genetic material in a biological sample using the technique known as PCR (Polymerase Chain Reaction). The device comprises a reaction chamber which incorporates means of heating arranged to heat said chamber. The detection method is characterized... Agent: Fulwider Patton LLP
20100112585 - Method for enriching methylated cpg sequences: Compositions and methods are provided for facilitating the enrichment of single-stranded DNA containing methylated CpG in a mixture containing methylated and unmethylated DNA. The compositions relate to methylation-binding protein domains that selectively bind to methylated single strand DNA. In embodiments of the invention, the methylated DNA is eluted in 0.4M-0.6M... Agent: Harriet M. Strimpel, D. Phil.
20100112594 - Method for enumerating mammalian cell micronuclei with an emphasis on differentially staining micronuclei and the chromatin of dead and dying cells: The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes differential staining of chromatin from dead and dying cells, to distinguish the chromatin from micronuclei and nuclei that can be detected based upon... Agent: Nixon Peabody LLP - Patent Group
20100112557 - Method for high resolution melt genotyping: Various methods are described that provide for high resolution melt (HRM) genotyping. The embodiments include providing a locus specific primer and two allele specific primers each having a 5′ end with a short tail, providing a nucleic acid having a single nucleotide polymorphism (SNP) base located within 1-20 base pairs... Agent: Life Technologies Corporation C/o Intellevate
20100112556 - Method for sample analysis using q probes: A method of sample analysis is provided. In certain embodiments, the method may comprise: a) contacting a plurality of Q probes with a nucleic acid sample comprising a target polynucleotide under hybridization conditions to form a plurality of flap endonuclease substrates each comprising a Q probe and a site in... Agent: Agilent Technologies Inc.
20100112555 - Method for the diagnosis of colorectal cancer: The object of the present invention refers to an in vitro method for diagnosing colorectal cancer based on the determination from a biological sample obtained from a subject, of promoter methylation status of at least one of the genes APC, RARB2 and p14 and, optionally, MGMT and p16. Likewise, object... Agent: Cantor Colburn, LLP
20100112574 - Method for the simultaneous determination of blood group and platelet antigen genotypes: RBC and platelet (Plt) alloimmunization requires antigen-matched blood to avoid adverse transfusion reactions. Some blood collection facilities use unregulated Abs to reduce the cost of mass screening, and later confirm the phenotype with government approved reagents. Alternatively, RBC and Plt antigens can be screened by virtue of their associated single... Agent: David S. Resnick
20100112593 - Method of predicting the clinical response to chemotherapeutic treatment with alkylating agents: The present invention provides methods relating to chemotherapeutic treatment of a cell proliferative disorder. In particular, a method is provided for predicting the clinical response to certain types of chemotherapeutic agents. Alkylating agents, used for the treatment of certain types of tumors including tumors of the nervous system and lymph... Agent: Dla Piper LLP (us)
20100112568 - Methods and kits for diagnosis of multiple sclerosis in probable multiple sclerosis subjects: Provided are methods and kits for determining the probability of a subject diagnosed with probable multiple sclerosis to develop definite diagnosis of multiple sclerosis by determining the expression level of polynucleotides which are differentially expressed between subjects diagnosed with probable multiple sclerosis and which further develop definite multiple sclerosis and... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20100112564 - Methods for detecting therapeutic effects of anti-cancer drugs: precancerous lesions, and subject having precancerous lesions and being treated with an anti-cancer agent; (2) isolating total microbial genomic DNA from the fecal samples to provide total microbial genomic DNA; (3) comparing the total microbial genomic DNA using fingerprint spectrum analysis; (4) identifying key fingerprint bands correlated with the effect... Agent: Connie Wan Obenomics Inc.
20100112592 - Methods for identifying an increased likelihood of recurrence of breast cancer: Methods of identifying a mammal having an increased likelihood of recurrence of breast cancer includes identifying in a breast tissue sample of the mammal expression of at least two genes selected from the group consisting of Hs.125867 (EVL), Hs.591847 (NAT1), Hs.208124 (ESR1), Hs.26225 (GABRP), Hs.408614 (ST8SIA1), Hs.480819 (TBC1D9), Hs.504115 (TRIM29),... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20100112581 - Methods for normalizing and for identifying small nucleic acids: The present teachings are generally directed to methods for normalizing at least one species of small nucleic acid that is present in a population of small nucleic acid species, wherein the relative concentration of at least one small nucleic acid species is substantially greater than the relative concentration of at... Agent: Life Technologies Corporation C/o Intellevate
20100112588 - Methods for sanger sequencing using particle associated clonal amplicons and highly parallel electrophoretic size-based separation: Methods for highly parallel Sanger sequencing are discussed. In particular, provided herein are methods using particles to clonally amplify templates and to introduce the amplified nucleic acids into many parallel channels with a single template per channel. Once in the channels, the nucleic acids are separated by size using electrophoresis... Agent: Javier Farinas
20100112573 - Methods, compositions, and kits comprising linker probes for quantifying polynucleotides: The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer... Agent: Life Technologies Corporation C/o Intellevate
20100112565 - Methods, kits, and reaction mixtures for high resolution melt genotyping: Various methods are described that provide for high resolution melt (HRM) genotyping. Some embodiments comprise providing a locus specific primer, and two allele specific primers each comprising at least one single nucleotide polymorphism (SNP) allele-hybridizable sequence, wherein at least one of the allele specific primers also comprises at least one... Agent: Life Technologies Corporation C/o Intellevate
20100112569 - Microfluidic devices and methods of generating and using same: A microfluidic device comprising a substrate having formed therein microfluidic paths, at least a portion of the microfluidic paths having attached thereto a plurality of monolayers, wherein at least a portion of the monolayers comprises a photoactivatable group capable of generating a reactive group upon exposure to a light source,... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20100112563 - Multiplex analysis of nucleic acids: A method for identifying target nucleic acids includes the steps of contacting a sample containing a plurality of target nucleic acids with at least one series of nucleotide primers under conditions that allow binding of said primers to at least one of said target nucleic acids and labeling of said... Agent: Osha Liang L.L.P.
20100112562 - Mutation implicated in abnormality of cardiac sodium channel function: A novel mutation in the SCN5A gene is associated with loss of cardiac sodium channel function. Analysis of the novel mutation provides an early diagnosis of subjects with cardiac diseases or disorders caused by loss of cardiac sodium channel function, particularly Brugada syndrome. Diagnostic methods include analyzing the sequences of... Agent: The Nath Law Group
20100112575 - Noninvasive diagnosis of fetal aneuploidy by sequencing: Disclosed is a method to achieve digital quantification of DNA (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence... Agent: Peters Verny , L.L.P.
20100112554 - Nucleic acid ligands to complex targets: The present invention relates to a nucleic acid ligands capable of binding to one or more target molecules in a complex mixture.... Agent: Birch Stewart Kolasch & Birch
20100112552 - Nucleic acid-binding chips for detecting nitrogen deficiencies as part of bioprocess control: The invention relates to nucleic acid-binding chips for monitoring bioprocesses, specifically for detecting nitrogen deficiencies. Said chips carry probes that are sensitive to at least three of the following 50 genes: kdgR, citA, htrA, ycn1, yppF, trpB, ggt, alsR, glnA, nrgA, yciC, yvtA, nrgB, ycnJ, glnR, yvlA, yncE, yvlB, trpF,... Agent: Ratner Prestia
20100112559 - Primer set for amplifying obesity gene, reagent for amplifying obesity gene containing the same, and the uses thereof: Primer sets for amplifying target regions containing sites to be detected in the obesity gene (the β2AR gene, the β3AR gene, and the UCP1 gene) by a gene amplification method are provided, wherein the primer sets can amplify the regions specifically. Three pairs of primer sets are used including forward... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20100112558 - Probe bead synthesis and use: The present invention relates to the field of methods and devices of miniaturized synthesis. More specifically, the present invention relates to the parallel synthesis of large number of different types of molecules and oligomers, such as oligonucleotides (oligos), peptides, lipids, carbohydrates, small ligand molecules, and other organic and inorganic molecules... Agent: Xiaolian Gao
20100112567 - Random access system and method for polymerase chain reaction testing: A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends... Agent: Siemens Corporation Intellectual Property Department
20100112578 - Test chip, detection apparatus, and method for detecting analyte: A test chip for detecting an analyte modified with a modulator releasing electrons upon photoexcitation, comprising: semiconductor electrode part including a metal layer formed on a semiconductor layer; a probe immobilized on the metal layer, the probe trapping the analyte; and a counter electrode part including a conductive layer. A... Agent: Brinks Hofer Gilson & Lione
20100112587 - Transcriptomic biomarkers for individual risk assessment in new onset heart failure: A novel transcriptomic biomarker for prognosis in heart failure has a direct clinical application in prediction of prognosis in new onset heart failure, heart disease, heart disorders and associated heart conditions. This approach should improve individualization of cardiac care and help identify patients at highest risk for circulatory collapse within... Agent: Darby & Darby P.C.
20100112591 - Tumor suppressor gene: A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells... Agent: Fish & Richardson PC
20100112566 - Vipr1s as modifiers of the e2f/rb pathway and methods of use: Human VIPR1 genes are identified as modulators of the E2F/RB pathway, and thus are therapeutic targets for disorders associated with defective E2F/RB function. Methods for identifying modulators of E2F/RB, comprising screening for agents that modulate the activity of VIPR1 are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP
20100112553 - Luciferase gene optimized for use in imaging of intracellular luminescence: The present invention provides a gene construct encoding pH insensitive luciferase for visualizing intracellular information, wherein an intracellular expression activity is higher compared with a gene construct of luciferase derived from a firefly.... Agent: Leydig Voit & Mayer, Ltd
20100112596 - Kit for deciding degree of malignancy in prostate cancer and method of using the same: The present invention relates to kits and methods for determining (diagnosing) prostate cancer malignancy and to predict patient prognoses. In addition to the Gleason's classification and the TMN classification, the invention kit and methods provide improved procedures with molecular markers. These new diagnostic methods provide methods capable of determining prostate... Agent: Osha Liang L.L.P.
20100112597 - Methods for quantifying protein leakage from protein based affinity chromatography resins: The present invention provides methods of quantifying protein leakage from a protein based affinity chromatography media (e.g., protein A, protein G and protein L based affinity chromatography media), where such a protein is used for isolating and/or removing a molecule which binds the protein (e.g., an immunoglobulin).... Agent: Millipore Corporation
20100112603 - Method for predicting the response to a treatment: The invention is related to a method of predicting the response to a treatment with a HER inhibitor in a patient comprising the steps of assessing a biomarker or a combination of biomarkers selected from the group consisting of amphiregulin, an epidermal growth factor, a transforming growth factor alpha, and... Agent: Hoffmann-la Roche Inc. Patent Law Department
20100112600 - Methods and compositions for modulating synapse formation: The invention provides methods of modulating synapse formation. Methods for identifying agents to modulate synapse formation are also disclosed.... Agent: Keown & Zucchero, LLP
20100112601 - Novel monoclonal antibody and use of the same: The present invention provides an anti-PAC1 monoclonal antibody capable of recognizing a PAC1 having a native structure, a PAC1 activity regulator (in particular, activity inhibitor) containing the antibody, a prophylactic/therapeutic agent for a disease associated with accentuation of a bioactivity of PAC1, containing the antibody, a diagnostic reagent for a... Agent: Edwards Angell Palmer & Dodge LLP
20100112602 - Protein-protein interaction biosensors and methods of use thereof: The invention provides methods and reagents for identifying an agent, such as by screening a library of agents, that modulates the interaction of two or more polypeptides, the method comprising: introducing into a cell at least a first polypeptide, each comprising a binding domain, wherein the first polypeptide comprises a... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20100112598 - Novel assay for inositol phosphorylceramide synthase activity: Disclosed is a simple and reproducible method for assaying inositol phosphorylceramide synthase activity that employs a fluorescence resonance energy transfer pair for measuring enzyme activity. The invention also includes a novel method for identifying IPC synthase inhibitors.... Agent: Jonathan P. O''brien, Ph.d. Honigman Miller Schwartz And Cohn
20100112604 - Home food test kit and method of use: A home test kit for detecting the presence or absence of melamine (1,3,5-triazine-2,4,6-triamine) has a sample extract container in which a volume of extract solution is present; a test strip, the test strip being a lateral flow device for detecting melamine (1,3,5-triazine-2,4,6-triamine) in a food or beverage sample; and wherein... Agent: David L. King, Sr.
20100112605 - Biomarker for the medicine and the biology of the reproduction: The present invention relates to a new biomarker for the medicine and the biology of reproduction, in particular for in vitro fertilization (IVF) outcome. It relates to methods for predicting IVF outcome and for selecting the subject for IVF.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100112606 - Measurement and analysis of leukotrienes: The present invention provides a new analytical method for measuring leukotrienes in a clinical sample using liquid chromatography and tandem mass spectrometry (LCMSMS). The method provides a simple, rapid and low-cost assay for the measurement of leukotriene levels in a clinical sample with high accuracy and precision over the physiological... Agent: Sheridan Ross PC
20100112608 - Method of diagnosing lawsonia intracellularis: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation
20100112607 - Methods for determining active ingredients in pro-drug peg protein conjugates with releasable peg reagents (in vitro de-pegylation): The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water-soluble polymer and measuring... Agent: Marshall, Gerstein & Borun (baxter)
20100112609 - Determining and reducing immunoresistance to a botulinum toxin therapy using botulinum toxin b peptides: The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunoresistance to botulinum toxin therapy in an individual, methods of reducing anti-botulinum toxin antibodies in an individual and... Agent: Allergan, Inc.
20100112610 - Determining and reducing immunoresistance to a botulinum toxin therapy using botulinum toxin b peptides: The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunoresistance to botulinum toxin therapy in an individual, methods of reducing anti-botulinum toxin antibodies in an individual and... Agent: Allergan, Inc.
20100112611 - Procedure for detecting microbial contamination by bioluminescence in associative acrylic thickeners and products containing them: A procedure for detecting microorganisms by bioluminescence in an aqueous formulation containing an ASE or HASE-type polymer, which implements at least one step of dilution of the aqueous formulation. This dilution step, and notably the regulation of the dilution factor, allows the bioluminescence technique, up to now ineffective on this... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100112613 - Biosensor membranes composed of polymers containing heterocyclic nitrogens: Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over... Agent: Abbott Diabetes Care Inc. Bozicevic, Field & Francis LLP
20100112614 - Coupled antenna impedance spectroscopy: It has been found advantageous to deploy coiled antennas as transmitters and receivers for acquiring the dielectric spectrum of materials. This method of impendence spectroscopy has been used to determine the concentration of glucose and other small polar molecules in vitro, as well as in vivo by placement on the... Agent: Edward S. Sherman, Esq.
20100112612 - Method for determining an analyte using an analytical test strip with a minimal fill-error viewing window: A method for determining an analyte (such a glucose) in a bodily fluid sample includes introducing a bodily fluid sample (e.g., a whole blood sample) into a sample-receiving chamber of an analytical test strip. The method also includes verifying that the bodily fluid sample has filled at least a working... Agent: Philip S. Johnson Johnson & Johnson
20100112617 - Evaluating rtk target drugs: Methods of evaluating receptor tyrosine kinase drug efficacy are demonstrated. The methods generally relate to evaluation methods using phospho-RTK over total RTK ratio (pRTK/tRTK). An algorithm is provided that allows the user to combine the pRTK/tRTK ratios from several kinase together with other kinds of measurements to obtain a PDX... Agent: Baker & Mckenzie LLP
20100112615 - Glycosyltransferase activity: We describe the production of nucleotide sugars other than uridine diphosphate glucose (UDP-glucose), for example UDP-rhamnose, and the use of these nucleotide sugars in the modification of acceptor molecules.... Agent: Speckman Law Group PLLC
20100112616 - Novel beta-galactoside-a2,6-sialyltransferase, a gene encoding thereof, and a method for enhancing enzyme activity: The present invention provides an extremely useful and novel β-galactoside-α2,6-sialyltransferase having an optimum reaction pH in a neutral to alkaline range, and a nucleic acid encoding the sialyltransferase. The present invention further provides a vector carrying a nucleic acid encoding the sialyltransferase, and a host cell transformed with the vector,... Agent: Birch Stewart Kolasch & Birch
20100112618 - Measurement of the activity of a kynurenine-converting enzyme and/or a kynurenic-acid, anthranilic-acid and/or 3-hydroxykynurenine-producing enzyme: The present invention relates to a method of measuring the activity of a kynurenine-converting enzyme and/or a kynurenic-acid-, anthranilic-acid- and/or 3-hydroxykynurenine-producing enzyme, the method comprising the step of measuring the activity in the presence of an interfering sample, preferably selected from a CSF (cerebrospinal fluid) or serum, and detecting the... Agent: Chalker Flores, LLP
20100112620 - Biorhythm information acquisition method: A method of acquiring information on a biorhythm on the basis of a variation with time of the quantity of a physiologically active substance in tear and/or saliva is provided.... Agent: K&l Gates LLP
20100112619 - Ligand-containing micelles and uses thereof: Ligand-containing micelles and various compositions, kits and methods for their preparation and use are provided.... Agent: Life Technologies Corporation C/o Intellevate
20100112621 - Analytical method for protein mapping using hydrogen/deuterium exchange: Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide mapping, include the steps of (a) providing a peptide or protein comprising a solvent accessible hydrogen; (b) exchanging the solvent accessible hydrogen for a... Agent: Sutherland Asbill & Brennan LLP
20100112622 - Method for detecting phenothiazine-derivative color and color-developer reagent used therein: The present invention provides a phenothiazine-derivative color-measuring method that can detect a phenothiazine-derivative color even at a wavelength longer than the wavelength that exhibits maximum absorption. A phenothiazine-derivative color is detected, by adding a 5-hydroxy-1-(4-sulfophenyl)-4-(4-sulfophenylazo)pyrazole-3-carboxylic acid salt, 6-hydroxy-5-(4-sulfophenylazo)-2-naphthalenesulfonic acid salt, 3-hydroxy-4-(4-sulfonaphthylazo)-2,7-naphthalenedisulfonic acid salt, 7-hydroxy-8-(4-sulfonaphthylazo)-1,3-naphthalenedisulfonic acid salt, 3′,6′-dihydroxy-2′,4′,5′,7′-tetraiodospiro[isobenzofuran-1(3H),9′-(9H)xanthene]-3-one salt, 3′,6′-dihydroxy-2′,4′,5′,7′-tetrabromo-4,5,6,7,-tetrachlorospiro[isobenzofuran-1(3H),9′-[9H]xanthene]-3-one salt,... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20100112623 - Bacteria analyzer, method for analyzing bacteria, and a computer program product: A bacteria analyzer comprising: a sample preparing section for preparing a measurement sample from a specimen; a detector for detecting bacteria contained in the measurement sample prepared by the sample preparing section; and a controller including a memory under control of a processor, the memory storing instructions enabling the processor... Agent: Brinks Hofer Gilson & Lione
20100112629 - Cell block cassette device: A tissue cassette assembly includes a housing having a recess formed therein, and a compressible reservoir disposed partially or wholly inside of, or otherwise attached in fluid communication with, the housing recess, the compressible reservoir containing a tissue embedding material. The tissue cassette further includes a port disposed in the... Agent: VistaIPLaw Group LLP
20100112625 - Method and apparatus for processing tissue samples using a sensor: An apparatus and a method for processing tissue samples are described. The apparatus comprises: at least one retort for accommodating tissue samples; at least one container for storing alcohol or xylene; a valve adapted to connect the at least one retort with the at least one container depending on an... Agent: Alexander R Schlee SchleeIPInternational P.C.
20100112624 - Method for operating a tissue processor, and tissue processor: A method for operating a tissue processor and a respective tissue processor for performing this method are described for the processing tissue samples. The tissue processor comprises at least one retort for receiving the tissue samples and at least one container for receiving a process medium. The process medium is... Agent: Alexander R Schlee SchleeIPInternational P.C.
20100112628 - Methods and assays for detecting and quantifying pure subpopulations of white blood cells in immune system disorders: Methods for detecting nonactivated basophils in a whole blood sample obtained from a normal healthy subject, methods for determining a subject's susceptibility to an allergic reaction to an allergen, where the subject has no known allergy to the allergen, methods for measuring a response to challenge with a potential allergen... Agent: Greenberg Traurig, LLP
20100112627 - System and method for displaying three-dimensional object scattergrams: System and method for displaying three-dimensional object scattergrams of particles are provided. In one embodiment, at least two parameters associated with at least one particle in a biological sample are detected and stored as data. An initial two-dimensional scattergram of the data is created with the two dimensions corresponding to... Agent: Sterne Kessler Goldstein & Fox, P.l.l.c.
20100112626 - Use of semenogelin in the diagnosis, prognosis and treatment of cancer: Method of diagnosing cancer in a mammal comprising assaying a test sample from the mammal for an increased level of semenogelin, wherein the increased level of semenogelin in the test sample is diagnostic for the cancer; methods of prognosticating and assessing the effectiveness of treatment of a cancer in a... Agent: Leydig, Voit & Mayer, Ltd.
20100112631 - Chip having microchannel for counting specific micro particles among floating micro particle mixture by optical means and a method for counting micro particles using the same: A microchannel chip for counting floating microparticles with an optical method is provided. The depth of the microchannel chip is made to be a depth of field such that a clear and sharp optical image of microparticles can be obtained, without necessarily diluting the microparticle mixture inside the microchannel. Consequently,... Agent: Fenwick & West LLP
20100112630 - Methods for measuring microbiological content in aqueous media: A process for measuring total microbiological content in an aqueous medium includes adding a fluorescent dye to the aqueous medium, measuring the fluorescent signal in the aqueous medium to obtain a baseline fluorescent signal, releasing intracellular content of the microbiological matter into the aqueous medium by lysing the microbiological matter,... Agent: General Electric Company Ge Global Patent Operation
20100112632 - Composter mechanism: A rotary composter having a fuselage member where a drive system is configured to rotate the fuselage member where the end caps are substantially stationary and do not rotate and the fuselage member has a plurality of longitudinally extending slats contained therein.... Agent: Hughes Law Firm, PLLC
20100112633 - Two-step enzyme method for preparing 7-aminocephalosporanic acid: The present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of yeast Trigonopsis variabilis, having a specific activity of 105% higher than that of parent D-amino acid oxidase. The method has no need of... Agent: Mcdermott Will & Emery LLP
20100112634 - Yeast strains autonomously producing steroids: The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC
20100112635 - Protein hydrolysates enriched in peptides having a carboxy terminal proline residue: A method of enzymatically producing a protein hydrolysate from a protein substrate is described, wherein a proline-specific endoprotease or a composition containing a proline-specific endoprotease and optionally a subtilisin or a metallo endoprotease, and other enzymes such as carboxypeptidases, is used to produce a protein hydrolysate enriched in peptide fragments... Agent: Nixon & Vanderhye, PC
20100112639 - Enhanced production and purification of a natural high intensity sweetener: Recombinant P. pastoris producing natural sweet proteins and methods for engineering these recombinant yeast are described. Methods for enhancing foreign protein production in yeast fermentation and improved methods for purification of foreign proteins produced in yeast fermentation are presented.... Agent: Ratner Prestia
20100112636 - Inducible/regulated gene expression system in e coli: An expression system for transforming E. coli with a nucleic acid molecule of interest has an operator sequence of a cmt operon operatively linked to a promoter for the operator, and, a repressor sequence from a cym operon operatively linked to a promoter for the repressor. The expression system may... Agent: National Research Council Of Canada
20100112637 - Polypeptides having alpha-amylase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having alpha-amylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes North America, Inc.
20100112638 - Recombinant host cell for the production of a compound of interest: We describe a recombinant host cell for the production of a compound of interest as well as isolated fungal promoter DNA sequences, to DNA constructs, vectors, and fungal host cells comprising these promoters in operative association with coding sequences encoding a compound of interest. We also describe methods for expressing... Agent: Nixon & Vanderhye, PC
20100112640 - Polynucleotide: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment... Agent: Cozen O'connor, P.C.
20100112641 - Process for producing and purifying factor viii and its derivatives: Disclosed is a method for producing proteins having factor VIII procoagulant activity in serum-free medium by in vitro culturing of mammalian cells, wherein the serum-free medium contains an inhibitor against the protease released from cultured cells. In accordance with this invention, the inhibitor can protect the cleavage of a target... Agent: Frommer Lawrence & Haug
20100112642 - Production of cpd glycosylases: Recombinant forms of DNA sequences for CPD glycosylases, including the bacteriophage T4 gene denV, are described that are capable of expression at high levels. Active CPD glycosylases can be recovered from inclusion bodies resulting from the high expression using, for example, a homogenization process which employs stream mixing, and the... Agent: Estee Lauder Companies
20100112643 - Method for direct capture of ribonucleic acid: A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a target ribonucleic acid; denaturing the target ribonucleic acid; and incubating the sample to allow... Agent: Naval Research Laboratory Associate Counsel (patents)
20100112644 - Methods for detection and quantitation of small rnas: Improved methods that increase the specificity and sensitivity of detection of small RNAs, including miRNAs, using oligonucleotide primers and nucleic acid amplification, are provided. Reaction conditions that result in preferential decrease in cDNA synthesis of RNAs other than the small RNA molecules targeted for detection during miRNA tailing and reverse... Agent: Greenlee Winner And Sullivan P C
20100112645 - Generation of modified polymerases for improved accuracy in single molecule sequencing: Provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are less than the branching fractions of the polymerases from which they were derived, or branching fractions that are less than about 25% for a phosphate-labeled nucleotide analog. Also provided are compositions comprising modified recombinant polymerases that exhibit... Agent: Quine Intellectual Property Law Group, P.C.
20100112646 - Enzymatic hydrolysis of a cellulose material treated with an ionic liquid: A process for preparing glucose from a cellulose material, in which a cellulose-comprising starting material is provided and treated with a liquid treatment medium comprising an ionic liquid whose anions are selected from among polyatomic anions and the cellulose-comprising material which has been treated with the ionic liquid is subjected... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100112647 - Method for producing an acidic substance having a carboxyl group: An acidic substance having a carboxyl group is produced by culturing in a medium a microorganism which has been modified to enhance expression of the ybjL gene, and collecting the acidic substance having a carboxyl group from the medium.... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC
20100112648 - (r)-hydroxynitrile lyase from brassicaceae: The invention concerns a polypeptide which can be isolated from the Brassicaceae family and which has at least the activity of a hydroxynitrile lyase (HNL). The hydroxynitrile lyase of the invention is the first HNL from the Brassicaceae family. The plants (Arabidopsis) from which this enzyme or its gene is... Agent: Joyce Von Natzmer Pequignot + Myers LLC
20100112649 - Compositions, methods and uses for growth of microorganisms and production of their products: Embodiments of the present invention report compositions, methods and uses for growth and/or production of byproducts, products and/or co-products from algal cultures. Certain embodiments of the present invention report using wastewaters to grow microorganisms for producing one or more products, byproducts or co-products from the microorganisms. Other embodiments report compositions... Agent: Faegre & Benson LLP Patent Docketing - Intellectual Property
20100112650 - Powdery lipase preparation, method for producing the same and use thereof: The present invention discloses a powdery lipase preparation which is a granulated material comprising a lipase derived from Rhizopus oryzae and/or a lipase derived from Rhizopus delemar and a soybean powder having a fat content of 5 mass % or more. A lipase activity is improved by using this powdery... Agent: Buchanan, Ingersoll & Rooney PC
20100112651 - Compositions and methods for manipulating carbon flux in cells: Nucleotide and protein sequences that encode enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods of manipulating carbon flux in a cell also are provided.... Agent: K&l Gates LLP Henry W. Oliver Building
20100112653 - Process of producing a fermentation product: The present invention relates to processes for producing a fermentation product from starch-containing material comprising: (a) saccharifying starch-containing material with an alpha-amylase at a temperature below the initial gelatinization temperature of said starch-containing material; (b) fermenting using a fermenting organism, wherein a phytase is present during steps (a) and/or (b).... Agent: Novozymes North America, Inc.
20100112654 - Microorganisms for the production of 1,4-butanediol: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.... Agent: Mcdermott, Will & Emery
20100112655 - Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria: A high flux of metabolites from pyruvate to 2,3-butanediol in Lactobacillus plantarum was achieved through genetic engineering. Substantial elimination of lactate dehydrogenase activity in the presence of heterologously expressed butanediol dehydrogenase activity led to 2,3 butanediol production that was at least 49% of the total of major pyruvate-derived products.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20100112657 - Nucleic acids and constructs for increasing galactose catabolism and methods therefor: Provided are a recombinant gene associated with increased galactose catabolism, and a recombinant vector and microorganism including the gene. Also disclosed are a method of producing ethanol from a galactose-containing carbon source by culturing the microorganism including the gene in a galactose-containing carbon source such that ethanol is produced, and... Agent: Cantor Colburn, LLP
20100112656 - Re-engineering bacteria for ethanol production: The invention provides recombinant bacteria, which comprise a full complement of heterologous ethanol production genes. Expression of the full complement of heterologous ethanol production genes causes the recombinant bacteria to produce ethanol as the primary fermentation product when grown in mineral salts medium, without the addition of complex nutrients. Methods... Agent: Edwards Angell Palmer & Dodge LLP
20100112658 - Transformed saccharomyces cerevisiae engineered for xylose utilization: Recombinant Saccharomyces cerevisiae produced by transformation with heterologous polynucleotide sequences coding for xylulokinase (XKS) from Yersinia pestis and xylose isomerase (XI) are capable of xylose utilization. The transformants express these heterologous polynucleotides at a sufficient functional level to grow aerobically on xylose as the sole carbon source. Further transformation of... Agent: Usda-ars-office Of Technology Transfer National Ctr For Agricultural Utilization Research
20100112659 - Fermentation process: A process for the biosymbiotic fermentation of one or more microbe species selected for production of bioactive molecules. These microbe species (bio-hosts) are fermented together with both botanical sources or bacterial, fungal or algal organisms (growth-symbiots) as promoter stimulants. In this manner yields of the bioactive molecules equivalent to those... Agent: Dunlap Codding, P.C.
20100112660 - Method for derivatization of proteins using hydrostatic pressure: The present invention provides an effective method for derivatization of proteins using hydrostatic pressure to reversibly perturb the native conformation of a protein such that a normally buried functional group on the protein, such as an amino acid residue, or a ligand or cofactor associated with the protein, is exposed... Agent: Sheridan Ross PC
20100112661 - Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same: Oncokinase fusion polypeptides associated with hyperproliferative disorders and the polynucleotides encoding for such fusion polypeptides are provided. The fusion polypeptides have a C-terminal tyrosine kinase domain fused to an N-terminal domain that is not normally fused to the C-terminal tyrosine kinase domain and they possess constitutively activated tyrosine kinase activity.... Agent: Theravance, Inc.
20100112662 - Microorganism for producing recombinant pig liver esterase: The invention relates to a method for the processing of reaction solutions, containing whole-cell catalysts, an aqueous component and an organic component, wherein the organic component contains the product to be enriched, with the following steps: a) adjustment of the pH value to less than 4; b) filtration of the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100112663 - Enzymatic treatment of skin and hide degreasing: The present invention relates to a method of degreasing skins and hides with certain variants of Humicola lanuginose lipase. More specifically, the invention relates to a process for enzymatic degreasing of skins and hides with lipase in the absence of surfactant at pH 6-13.... Agent: Novozymes North America, Inc.
20100112664 - Method of making macroporous cation exchange resins: Methods of making macroporous cation exchange resins are described. The macroporous cation exchange resins are in the form of particles such as beads that contain a hydrophilic, crosslinked, (meth)acrylic-type polymeric material. Additionally, methods of purifying a positively charged material using the macroporous cation exchange resins, methods of making chromatographic columns... Agent: 3m Innovative Properties Company
20100112665 - Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease: An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells as part of a Baculovirus expression system has been crystallized, and the three dimensional x-ray crystal structure... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20100112666 - Dehalogenases, nucleic acids encoding them and methods for making and using them: The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature.... Agent: Verenium Corporation Intellectual Property Department
20100112668 - Method for producing factor g derived from horseshoe crab: The invention provides a virus harboring a DNA encoding a subunit of limulus-derived factor G, the virus being capable of mass-producing a (1→3)-β-D-glucan assay reagent of satisfactory quality, steadily and at low cost, a cell harboring the virus, and a method of producing factor G by use of the cell.... Agent: Factor & Lake, Ltd
20100112667 - Microfluidic biological extraction chip: A microfluidic cartridge for isolating biological molecules having a capture chamber containing functionalized solid supports maintained in a fluidized state provides reduced pressure drops and bubble formation during microfluidic extraction. The cartridge may include an electric field lysis chamber and/or a chemical lysis chamber. The electric-field lysis chamber may comprise... Agent: Tomas Friend, LLC
20100112669 - Mdck cells lines supporting viral growth to high titers and bioreactor process using the same: The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and... Agent: Medimmune, LLC Patrick Scott Alban
20100112671 - Host cells for production of isoprenoid compounds: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP
20100112673 - Dna sequence encoding penicillin acylase, novel recombinant dna constructs and recombinant microorganisms carrying this sequence: The invention consists in a nucleotide sequence having the size of (2646) bp, wherein the order of nucleotides is identical to the order of the nucleotide sequence encoding penicillin acylase from Achromobacter sp. CCM 4824 (formerly Comamonas testosteroni CCM 4824), eventually of the fragments of this sequence having the length... Agent: Law Offices Of Albert Wai-kit Chan, PLLC
20100112674 - Microcin h47 plasmid selection system: The present invention relates generally to stabilized expression plasmid systems. The stabilized expression plasmid systems comprise an expression vector that includes a plasmid maintenance system (PMS) and, optionally, one or both of a polynucleotide encoding a selected antigen under control of a promoter, and a polynucleotide encoding a selectable marker... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.
20100112672 - Production of isoprenoids and isoprenoid precursors: The present invention provides genetically modified host cells and use of same for producing isoprenoid compounds.... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP
20100112670 - Regulated genetic suicide mechanism compositions and methods: Embodiments of the present invention relates to the incorporation and use of a regulated genetic suicide mechanism for use in the improved purification of biologics, including adjunct use in various eubacterial minicell production and purification methodologies. Described herein are high-yield eubacterial minicell-producing strains with genetic modifications that comprise a regulated... Agent: Knobbe Martens Olson & Bear LLP
20100112675 - Multi-staged composting: In various embodiments, the invention provides staged processes, or systems, for composting organic materials, such as waste plant and animal matter. In one aspect, the invention involves the staged passage of organic material through alternative composting ecologies, to optimize the diversity of decay organisms that may work on the organic... Agent: Knobbe Martens Olson & Bear LLP
20100112676 - Odor control methods and compositions: This invention is directed generally to methods of controlling the odor of a biological material, and more particularly to methods comprising providing the biological material with an Fe(III)-reducing bacteria and a source of Fe(III). This invention also is directed generally to compositions and kits for controlling the odor of a... Agent: Harness, Dickey, & Pierce, P.l.c
20100112677 - Sterile environment maintaining apparatus: The sterile environment maintaining apparatus according to the present invention comprises a sterile room 10 having an inlet opening 11 and an outlet opening 12, a HEPA filter 3 placed so as to cover the inlet opening 11 or the inlet opening 11 and the outlet opening 12 of the... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20100112678 - Analytical test strip with minimal fill-error sample viewing window: An electrochemical-based analytical test strip includes an electrically-insulating substrate, a patterned conductive layer disposed over the electrically-insulating substrate, a patterned insulating layer disposed over the patterned conductive layer, an enzymatic reagent layer disposed over the patterned conductive layer, a patterned adhesive layer disposed above the enzymatic reagent layer and a... Agent: Philip S. Johnson Johnson & Johnson
20100112679 - Method and apparatus for syringe-based sample introduction within a flow cytometer: An apparatus for introducing a specimen into a flow cytometer comprises: a syringe having a hollow barrel containing the specimen, a plunger partially within the barrel and a needle that extends into a volume of a nozzle of the flow cytometer; a one-way port in the nozzle forming a seal... Agent: Sterne Kessler Goldstein & Fox, P.l.l.c.
20100112680 - Indicator system for determining analyte concentration: A method for quantitatively sensing, using an indicator system based on diffusion in space and time of a reaction front, for determining and reporting the prevailing concentration or exposure history of an analyte in food, beverage, and pharmaceutical monitoring for the state of quality, for ripeness indication in fruit, for... Agent: The Webb Law Firm, P.C.
20100112681 - Microchip fluid control mechanism: Compressed gas is supplied from above to a specimen vessel having an open top. Transfer channels to reaction vessels are provided under a microchip and transfer channels extending from the reaction vessels are provided on the microchip. Transfer element is provided outside the microchip so as to supply the compressed... Agent: Young & Thompson
20100112682 - Total bacteria monitoring system: A system for measuring total microbiological content in an aqueous medium by adding a fluorescent dye to the aqueous medium, measuring the fluorescent signal in the aqueous medium to obtain a baseline fluorescent signal, releasing intracellular content of the microbiological matter into the aqueous medium by lysing the microbiological matter.... Agent: Wegman, Hessler & Vanderburg
20100112683 - Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.... Agent: Kilyk & Bowersox, P.l.l.c.
20100112684 - Cell culture dish for the embryoid body formation from embryonic stem cells: The present invention relates to a cell culture dish for the erabryoid body formation from embryonic stem cells, which facilitates efficient and stable differentiation of embryonic stem cells by forming embryoid body in grooves on the bottom of a support adhered on the back of the lid for the culture... Agent: Cantor Colburn, LLP
20100112686 - Short hairpin rnas for inhibition of gene expression: Methods, compositions, and kits that include small hairpin RNA (shRNA) useful for inhibition of gene expression, such as viral-mediated gene expression, are described.... Agent: Bozicevic, Field & Francis LLP
20100112685 - Thymidine kinase mutants and fusion proteins having thymidine kinase and guanylate kinase activities: The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution located toward the N-terminus from a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as... Agent: C. Rachal Winger C/o Ocip Group
20100112687 - Nucleic acid compounds for inhibiting erbb family gene expression and uses thereof: The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing one or more ERBB family gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.
20100112688 - Screening methods for compounds that modulate the activity of g-protein coupled receptors: The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eucaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or... Agent: Propat, LLC
20100112689 - Method of obtaining viable human cells, including hepatic stem/progenitor cells: The present invention is directed toward a method for obtaining from whole liver or a resection thereof a population of cells comprising viable, functional liver cells enriched in hepatocytes and hepatocyte stem/progenitor cells, compositions thereof, and uses therefore. Compositions include a composition of liver cells enriched in hepatocytes and hepatocyte... Agent: Foley And Lardner LLP Suite 500
20100112690 - Insert device for multiwell plate: An assembly comprises a multiwell test plate having a plurality of wells having an opening and a base surface, an insert plate having a plurality of inserts positioned to align with a corresponding one of the wells whereby the insert plate can be nested with the multiwell plate. Each of... Agent: Marshall, Gerstein & Borun LLP
20100112692 - Differentiation of human embryonic stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides a method to increase the expression of markers associated with the pancreatic endocrine lineage.... Agent: Philip S. Johnson Johnson & Johnson
20100112693 - Differentiation of human embryonic stem cells: The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependant kinase inhibitor to cause... Agent: Philip S. Johnson Johnson & Johnson
20100112691 - Stem cell aggregate suspension compositions and methods of differentiation thereof: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.... Agent: Sutherland Asbill & Brennan LLP
20100112694 - Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells: Dedifferentiation is a mechanism whereby specialized cells regain properties of their ancestors, including, in the extreme, stemness. We found that highly-purified cardiomyocytes isolated from adult mammalian hearts dedifferentiated rapidly when cultured in mitogen-rich medium. Such myocytes reentered the cell cycle and proliferated, expressing stem cell surface markers such as c-kit... Agent: Banner & Witcoff, Ltd.
20100112695 - Apparatus and methods for processing tissue to release cells: An apparatus and methods for processing tissue to release biological material including cells are disclosed.... Agent: Baxter Healthcare Corporation
20100112696 - Apparatus and methods for processing tissue to release cells: An apparatus and methods for processing tissue to release biological material including cells are disclosed.... Agent: Baxter Healthcare Corporation
20100112697 - Process for the high-purity isolation of mesenchymal stem cells derived from placental chorionic plate membrane: The present invention provides a method for isolating mesenchymal stem cells derived from a placental chorionic plate membrane, the method including: (a) harvesting a chorionic plate membrane from a detached placenta; (b) harvesting cells present in the chorionic plate membrane obtained in step (a) by scraping; (c) adding a solution... Agent: The Nath Law Group
20100112698 - Device for trapping extraneous gas: A device for trapping extraneous gas or bubbles is disclosed. The device is defined as having a gas collection area in a tapered neck portion such that when used as a cell culturing apparatus, extraneous gas or bubbles are trapped and isolated from the cell growth areas where cells or... Agent: Corning Incorporated
20100112699 - Porous composite biomaterials and production method of the same: The invention discloses a porous composite biomaterial comprising of poly(γ-glutamic acid)-g-chondroitin sulfate (γ-PGA-g-CS) copolymer and poly(ε-caprolactone). The composite biomaterial provides a three-dimensional microenvironment for using as a scaffold for tissue engineering and for supporting the attachment and proliferation of cells. The invention also discloses a method of producing a porous... Agent: Muncy, Geissler, Olds & Lowe, PLLC
20100112700 - Large scale disposable bioreactor: A reusable, disposable device for culturing plant tissues or cells including a non-rigid container having dimensions and gas exchange ports designed for maintaining oxygen saturation and shear forces suitable for culturing plant tissue or cells in 400 liters or more of culture medium is provided. Also provided are methods for... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20100112701 - Reductase, gene thereof and method of using the same: The present invention relates to a protein which can asymmetrically reduce an ortho-substituted phenylglyoxalic acid compound to produce an aide or ester compound of corresponding optically-active ortho-substituted mandelic acid compound with a good optical yield, a DNA encoding the protein, a process for producing the protein from the DNA, and... Agent: Sughrue Mion, PLLC
20100112702 - Method designed to divert glucose away from the glycolytic pathway: A method to divert glucose away from glycolysis is described. The method is based on a planned “glucose sink” by introduction, into tumor cells, of nucleotide sequences from known genes whose products are comprised in lactose synthase enzymatic complex. The method is a process designed to correct, replenish or de... Agent: Benjamin Y. KleinPrevious industry: Education and demonstration
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