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Chemistry: molecular biology and microbiology April category listing, related patent applications 04/10

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
04/29/2010 > patent applications in patent subcategories. category listing, related patent applications

20100105020 - Quantitative measurement of glycated hemoglobin: The invention relates to a method for quantitative measurement of glycated hemoglobin (HbAIc) in a blood sample containing hemoglobin molecules. In this method, the hemoglobin molecules are extracted from the blood sample, adsorbed onto a roughened metal surface and subjected to a Surface Enhanced Raman Scattering (SERS) measurement. The invention... Agent: Philips Intellectual Property & Standards

20100105021 - Stabilisation of biological cell markers: The invention provides compositions which stabilise the expression of cell surface markers. The invention further provides methods and kits comprising such compositions for use in stabilising the expression of cell surface markers. The invention is especially concerned with compositions for use in stabilising the expression of cell surface markers (such... Agent: Nixon Peabody LLP - Patent Group

20100105022 - Analyzing biological cell material based on different interactions between illumination light and cell components: It is described a device (100) for analyzing biological cell material (115). The device (100) comprises a light source arrangement (120), which is adapted for directing a first (131) and a second illumination light (132) towards the cell material (115), wherein the first (131) and the second (132) illumination light... Agent: Philips Intellectual Property & Standards

20100105023 - In vitro method modeling the consistency generated in vivo by food during the digestion thereof:

20100105027 - Detection of nucleic acids from multiple types of human papillomaviruses: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products... Agent: Gen Probe Incorporated

20100105025 - Devices for generating detectable polymers: This document provides systems, devices, and methods involved in generating detectable polymers. For example, diagnostic systems, diagnostic devices, primer systems, and collections of primer systems are provided.... Agent: Fish & Richardson P.C.

20100105026 - Optical measurement method for molecular detection using relaxation measurement in optically anisotropic nanoparticles and device for performing the method: Optical measurement methods are described that are suitable for determining the relaxation behavior of nanoparticles dispersed in a solution. The particles have optically anisotropic properties and are alignable by an external stimulus, for example, an electric or magnetic field. In this manner the optical detection of certain molecules that can... Agent: Lerner Greenberg Stemer LLP

20100105024 - Rapid test including genetic sequence probe: A rapid test kit may have a genetic probe, and antibody detecting probe or a combination of a genetic probe and an antibody detecting probe disposed within one or more test windows of the test kit. A cellulose filter paper membrane with a flow rate selected in a range of... Agent: Christopher Paradies, Ph.d.

20100105053 - Aptamer based sensors and related methods and systems: An aptamer based-sensor comprising: a target binding aptamer attaching a Raman probe and a metal coated surface; and related methods and systems... Agent: Llnl/steinfl & Bruno John H. Lee, Assistant Laboratory Counsel

20100105059 - Assay for chlamydia trachomatis by amplification and detection of chlamydia trachomatis pmpa gene: A region of the Chlamydia trachomatis pmpA gene has been identified which is useful for performing amplification assays to determine specifically whether C. trachomatis is present in the sample being tested. Oligonucleotides useful for performing thermal Strand Displacement Assay (tSDA) reactions on this gene are disclosed. The disclosed oligonucleotides can... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100105061 - Autoimmune genes identified in systemic lupus erythematosus (sle): The present invention relates to a genes and autoimmunity. More specifically, the invention relates to the identification of genes that are associated with Systemic Lupus Erythematosus (SLE) in children and/or adults. Also disclosed are methods for making and using the genetic selection tool used to identify SLE associated genes, and... Agent: Hogan & Hartson L.L.P.

20100105051 - Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.... Agent: Mccarter & English, LLP Boston

20100105034 - Detecting and treating dementia: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this... Agent: Fish & Richardson P.C.

20100105045 - Dnp63a gene and screening methods of anticancer agent by using it: This invention relates to a gene encoding ΔNp63α and screening methods of anticancer-drugs thereof, more specifically a gene encoding ΔNp63α and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and... Agent: Clark & Elbing LLP

20100105035 - Electroluminescent-based fluorescence detection device: The present invention provides compositions providing and methods using fluorescence detection device, comprising an electroluminescent light (EL) source, for measuring fluorescence in biological samples. In particularly preferred embodiments, the present invention provides an economical, battery powered and Hand-held device for detecting fluorescent light emitted from reporter molecules incorporated into DNA,... Agent: Medlen & Carroll, LLP

20100105060 - Fast results hybrid capture assay on an automated platform: The present invention comprises a method that provides fast and reliable results for detecting the presence of a target nucleic acid molecule in a sample.... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100105048 - Functionalized fluorescent nanocrystal detection system: The present invention include fluorescent nanocrystals which have high fluorescence intensity, are water soluble, exhibit physical and chemical stability, and whose spectral properties are detectably modified as the size of functional groups bonded to the nanocrystal surface change when contacted with target molecules in a sample. The molecules in the... Agent: Life Technologies Corporation C/o Intellevate

20100105054 - Gene expression in duchenne muscular dystrophy: Gene expression in peripheral blood from individuals with Duchenne muscular dystrophy (DMD), compared to control individuals, demonstrated differential gene sets that could be used in a method to diagnose DMD, to evaluate effect of DMD therapy, and/or to evaluate propensity to DMD.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20100105062 - Genetic markers for optimizing treatment for schizophrenia: This document provides methods and materials related to genetic markers for predicting response to a treatment for schizophrenia (SZ). For example, methods for using such genetic markers to select optimal treatments are provided.... Agent: Fish & Richardson PC

20100105038 - Genetic markers for weight management and methods of use thereof: This application relates to methods and tests that allow for the establishment of personalized weight-loss programs for a subject based upon the subject's metabolic genotype in key metabolic genes. Kits and methods are disclosed for determining a subject's metabolic genotype, which may be used to select an appropriate therapeutic/dietary regimen... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100105032 - Highly sensitive multiplex single nucleotide polymorphism and mutation detection using real time ligase chain reaction microarray: A method and apparatus for real-time, simultaneous, quantitative measurement of one or more single nucleotide polymorphisms in one or more target nucleic acids is provided. This method involves combining a ligase chain reaction (LCR), a ligase detection reaction (LDR), and/or a polymerase chain reaction (PCR) technique with an evanescent wave... Agent: Honeywell International Inc. Patent Services

20100105057 - Human diabetes susceptibility tnfrsf10d gene: The present invention relates to a diagnostic method of determining whether a subject is at risk of developing type 2 diabetes, which method comprises detecting the presence of an alteration in the TNFRSF10D gene locus in a biological sample of said subject.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100105044 - Ileal pouch-anal anastomosis (ipaa) factors in the treatment of inflammatory bowel disease: A common long term problem after Ileal Pouch-Anal Anastomosis (IPAA) is the inflammation of the pouch, called pouchitis. Additionally, about 5-10% of patients undergoing IPAA with a diagnosis of ulcerative colitis at the time of surgery are subsequently diagnosed with Crohn's disease. In one embodiment, the present invention provides methods... Agent: Davis Wright Tremaine LLP/los Angeles

20100105039 - Label-free colorimetric detection: The present invention provides a sensor system kit for detecting an analyte, consisting essentially of: a nucleic acid enzyme, wherein the nucleic acid enzyme cleaves a substrate in the presence of the analyte; the substrate for the nucleic acid enzyme, comprising a polynucleotide; an aggregator; and particles.... Agent: Evan Law Group LLC

20100105056 - Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two dimentional array: This invention relates to methods and apparati for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array, such as a gel, membrane, tissue biopsy, etc. Such manipulations particularly include assays and nucleic acid amplification protocols.... Agent: Klarquist Sparkman, LLP

20100105058 - Method for measuring dna methylation: The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on.... Agent: Panitch Schwarze Belisario & Nadel LLP

20100105031 - Method for prediction of the efficacy of vascularization inhibitor: Disclosed is a method for the prediction of the efficacy of a vascularization inhibitor. In the method, the anti-tumor effect of a vascularization inhibitor can be predicted by measuring the number of blood vessels surrounded by pericytes in a tumor and using the measurement value as a measure for the... Agent: Dickstein Shapiro LLP

20100105033 - Method for single nucleotide polymorphism and mutation detection using real time polymerase chain reaction microarray: A method and apparatus for real-time, simultaneous, qualitative measurement of one or more single nucleotide polymorphisms in one or more target nucleic acids is provided. This method involves combining a polymerase chain reaction (PCR) technique with an evanescent wave technique.... Agent: Honeywell International Inc. Patent Services

20100105047 - Method for the simultaneous determination of blood group and platelet antigen genotypes: RBC and platelet (Plt) alloimmunization requires antigen-matched blood to avoid adverse transfusion reactions. Some blood collection facilities use unregulated Abs to reduce the cost of mass screening, and later confirm the phenotype with government approved reagents. Alternatively, RBC and Plt antigens can be screened by virtue of their associated single... Agent: David S. Resnick

20100105064 - Method of screening test substances for treating or preventing a disease mediated by plasma cells: The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA... Agent: Nixon Peabody LLP - Patent Group

20100105037 - Methods for amplifying and detecting nucleic acid sequences: The present invention, in different aspects and embodiments, provides nucleic acid amplification and detection methods that are both sensitive and fast. In various aspects there are disclosed amplification methods employing different combinations of primers to which can achieve exponential amplification and strand displacement, such as to generate a more than... Agent: Michael Best & Friedrich LLP

20100105063 - Methods for evaluating the methylation status of a polynucleotide: The invention provides methods related to evaluating the methylation status of a polynucleotide that includes an internal control.... Agent: Leydig Voit & Mayer, Ltd

20100105043 - Methods for modulating embryonic stem cell differentiation: Described herein is Zscan4, a gene exhibiting 2-cell embryonic stage and embryonic stem cell specific expression. Identification of nine Zscan4 co-expressed genes is also described Inhibition of Zscan4 expression inhibits the 2-cell to 4-cell embryonic transition and prevents blastocyst implantation, expansion and outgrowth. Provided herein are methods of inhibiting differentiation... Agent: Klarquist Sparkman, LLP

20100105046 - Methods of diagnosing cardiovascular disease: The invention relates to predicting which individuals are at risk of developing atherosclerotic vascular disease, and once having disease, which individuals are at risk of experiencing plaque rupture which, depending on the site of the plaque, could produce myocardial infarction, stroke, critical limb ischemia, or other vascular event. The invention... Agent: Wolf Greenfield & Sacks, P.C.

20100105040 - Microfluidic systems including porous polymer electrodes: Microfluidic devices that incorporate a porous polymer electrode assemblies, including microfluidic device useful for detection of nucleic acids, as well as methods of using the microfluidic devices.... Agent: Life Technologies Corporation C/o Intellevate

20100105065 - Miniaturized fluid delivery and analysis system: The present invention provides a method for combining a fluid delivery system with an analysis system for performing immunological or other chemical of biological assays. The method comprises a miniature plastic fluidic cartridge containing a reaction chamber with a plurality of immobilized species, a capillary channel, and a pump structure... Agent: Agnew International Patent & Trademark Law Firm

20100105042 - Novel methods: e

20100105030 - Nucleic acid base pairs: The invention relates to non-natural bases and base pairs that expand the normal DNA-based encoding system. Compositions herein may comprise at least one non-natural base that may interact with another base via a Watson Crick-type hydrogen bonding geometry and/or a Hoogsteen-type hydrogen bonding geometry. The bases may be used in... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100105052 - Nucleic acid sequencing and process: The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid... Agent: Morgan, Lewis & Bockius, LLP (sf)

20100105028 - Probe for detecting nucleic acids: The invention relates to a probe for detecting nucleic acids, to a method for producing the probe, methods for carrying out analytical reactions and test kits containing the reagents that are required for carrying out the probe-based analytical reaction.... Agent: Briscoe, Kurt G. Norris Mclaughlin & Marcus, Pa

20100105049 - Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.... Agent: Grant Anderson LLP C/o Portfolioip

20100105041 - Reagents and methods for detecting cyp2d6 polymorphisms: The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the specific detection of clinically relevant CYP2D6 polymorphisms, in particular CYP2D6 polymorphisms associated with adverse drug response. The oligonucleotide sequences are also provided assembled as kits that can... Agent: Siemens Corporation Intellectual Property Department

20100105050 - Real time detection of genetic sequences using a bipartite probe: The present invention concerns a method for detection or quantification of a Target Genetic Sequence in a Genetic Sample using a Bipartite Probe. A Bipartite Probe is made of a Target Binding Sequence capable of hybridizing a Target Genetic Sequence and a Nucleic Acid Binding Probe Sequence capable of being... Agent: Butler, Snow, O'mara, Stevens & Cannada PLLC

20100105029 - Self-contained biological analysis: Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analyses include nucleic acid amplification and detection and immuno-PCR.... Agent: Ice Miller LLP

20100105036 - Sir2 activity: This invention relates to methods of screening compounds that modulate cellular and organismal processes by modification of the activity of SIR2 and/or transcription factors, e.g., p53, particularly methods of screening for compounds that modify lifespan and/or metabolism of a cell or an organism by modulation of the activity of SIR2... Agent: Proteus Patent Practice LLC

20100105055 - Systems and methods of analyzing nucleic acid polymers and related components: Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed.... Agent: Wolf Greenfield & Sacks, P.C.

20100105066 - Tissue rejection: This document relates to methods and materials involved in detecting tissue rejection (e.g., organ rejection). For example, this document relates to methods and materials involved in the early detection of kidney tissue rejection.... Agent: Fish & Richardson P.C.

20100105067 - Biomarkers for ovarian cancer: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition.... Agent: Edwards Angell Palmer & Dodge LLP

20100105070 - Diagnosis and treatment of preeclampsia: The present invention relates to biomarkers for preeclampsia as well as treatment of this disease. In particular, the invention relates to methods for diagnosis or aiding in the diagnosis of preeclampsia of a pregnant female mammal to detect elevated levels of free haemoglobin, particularly free fetal haemoglobin. This facilitates and... Agent: Edwards Angell Palmer & Dodge LLP

20100105074 - High throughput flow cytometry system and method: The invention provides systems, compositions, kits and methods for automated processing of biological samples and analysis using a flow cytometer.... Agent: Wilson, Sonsini, Goodrich & Rosati / Nodality, Inc

20100105068 - Hybridomas producing antibodies against non functional p2x7 receptor: The present invention relates to the production of anti non functional P2X7 receptor monoclonal antibodies from hybridoma cell lines.... Agent: Townsend And Townsend And Crew, LLP

20100105069 - Method for detecting human parvovirus antigen: A method for detecting human parvovirus/erythrovirus antigen in a sample comprises contacting a buffer having a pH in the range 3.0 to 4.0, suitably a citrate/trisodium citrate buffer, with the sample followed by the measurement of the antigen. The measurement of the antigen can be by virus capture enzyme immunoassay.... Agent: Birch Stewart Kolasch & Birch

20100105073 - Method for the production of antibodies: The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100105071 - Methods for predicting the onset of menarche: Embodiments of the invention provide methods for predicting the onset of menarche, i.e. a females first menstrual period, through the measurement of salivary hormone levels (e.g. 17-β estradiol, testosterone, progesterone, and/or 17 hydroxy-progesterone (17-OHP)). In particular, the methods described herein enable a reliable determination that menarche will, or will not... Agent: David S. Resnick

20100105072 - Methods of identifying respondents to hypoxia inducible factor 1-alpha inhibitors: This invention relates to methods of measuring HIF expression and activity, as well as measuring inhibition of HIF following administration of an HIF inhibitor useful in treating HIF related diseases. The present invention further relates to methods of identifying individuals who will respond to HIF inhibitors. The invention also relates... Agent: Pepper Hamilton LLP

20100105075 - Systems and methods of voltage-gated ion channel assays: Systems and methods are provided for optically measuring ion concentrations in biological samples. The systems and methods employ polymer-based optical ion sensors that include ion-selective ionophores and a pH sensitive chromionophore. Electrodes are providing for electrically stimulating the biological samples.... Agent: Ropes & Gray LLP

20100105080 - Methods for determining the bioactivity of tgf-beta in a composition: A novel method for determining the bioactivity of TGF-β in a sample of milk, raw protein source, or nutritional composition is provided. The method includes particular reconstitution steps, centrifugation steps, incubation steps, and activation steps. The bioactivity of the TGF-β in the sample may be measured in a HT-2 cell... Agent: Waddey & Patterson, P.C.

20100105081 - Detecting fungi in human samples: Methods and materials involved in detecting fungi in human samples are provided herein.... Agent: Fish & Richardson P.C.

20100105082 - Rapid detection nanosensors for biological pathogens: An assay test solution, a method for using, and an apparatus for the rapid detection of multiple pathogens using a FRET-based phenomenon. A volume of fluid, possibly containing pathogens, is passed through an intake and combined with an assay solution of quantum dot/antibody-antigen/quencher complexes that dissociate and recombine with the... Agent: Momkus Mccluskey, LLC

20100105076 - Analysis kit comprising at least two molecularly imprinted polymers and at least one marker, and method of analysis using same: The present invention relates to a kit for analysing at least one target molecule comprising at least a first molecularly imprinted polymer and a second molecularly imprinted polymer which are chemically identical or different, capable of interacting with the target molecule(s), and at least one marker, wherein said marker is... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100105077 - Means for detection and purification of cd8+ t lymphocyte populations specific to peptides presented in the context of hla: The invention concerns multimers developed from recombinant proteins analogues of MHC class I.... Agent: Sterne Kessler Goldstein & Fox, P.l.l.c.

20100105083 - Methods for determining the levels of tgf-beta in a composition: A novel method for determining the levels of TGF-β1 or TGF-β2 in a sample of milk, raw protein source, or nutritional composition is provided. The method involves, in some cases, reconstituting the sample; in some cases, centrifuging the sample; activating the sample using particular ratios of sample:acid:base; diluting the sample... Agent: Waddey & Patterson, P.C.

20100105078 - Compositions and methods of a phosphatidic acid binding protein: TGD2 proteins of Arabidopsis are proposed to be a substrate binding component of a lipid transfer complex in the inner chloroplast envelope membrane. Loss of function of this protein or other components of this complex may disrupt the endoplasmic reticulum (ER)-pathway of thylakoid lipid biosynthesis. In one embodiment, the present... Agent: Peter G. Carroll Medlen & Carroll, LLP

20100105079 - Bio surface acoustic wave (saw) resonator amplification with nanoparticles for detection of a target analyte: The present invention relates generally to a signal amplification method for a SAW resonator microsensor for analyzing test samples, containing target analyte including proteins and nucleic acids. The method comprising the steps: reacting the analyte in a sample with a first molecular recognition component and a second molecular recognition component... Agent: The Nath Law Group

20100105088 - method for diagnosing atherosclerotic plaques by measurement of cd36: The present invention relates to diagnosis, classification and monitoring of atherosclerotic plaques in an individual using measurement of the concentration of CD36 in a body fluid and/or the plaque as such. The present invention also relates to diagnosing the burden of atherosclerotic plaques in an individual. Furthermore, the invention relates... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20100105087 - Biomarkers for breast cancer: Low molecular weight (LMW) peptides have been discovered that are indicative of breast cancer. Evaluating patient samples for the presence of such LMW peptides is an effective means of detecting breast cancer and monitoring the progression of the disease, for example during treatment. The LMW peptides are particularly useful in... Agent: Foley And Lardner LLP Suite 500

20100105086 - Differential diagnosis for scleroderma: Use of IFI16 protein, fragments or peptides thereof for differential diagnosis of the limited cutaneous form of scleroderma (Ic-SSc) in a subject suspected of or at risk of having an autoimmune disease and the corresponding method of diagnosis and kit.... Agent: Millen, White, Zelano & Branigan, P.C.

20100105085 - Method of diagnosing and stratifying anti-phospholipid syndrome: Disclosed are a method and reagents for diagnosis of anti phospholipid syndrome based on the levels of certain anti 1 can antibodies.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100105084 - Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock: The present invention provides for the in vitro establishing of a prognosis for a subject in severe sepsis with at least two organ failures or in septic shock with at least two organ failures. Embodiments of the invention comprise the steps of measuring the level of the S100A8/A9 complex from... Agent: Alston & Bird LLP

20100105089 - Quantum dot biotags: A biotag that includes a biomolecule that includes a bio polymer sequence; an attaching polymer attached at an endpoint of the biopolymer sequence; and a quantum dot bound to the attaching polymer causing the attaching polymer to become fluorescently labeled is provided. Suggested biomolecules include, but are not limited to,... Agent: U S Army Research Laboratory Attn: Rdrl-loc-i

20100105090 - Secreted luciferase mluc7 and use thereof: The invention relates to the nucleotide and amino acid sequences and to the activity and use of the secreted MLuc7 luciferase.... Agent: Arent Fox LLP

20100105091 - Method for measuring the concentration of transient proteolytic activity in composite biological media containing cells: A method is provided for determining in real time the course of thrombin activity in a sample of clotting blood or plasma as it appears in and disappears from the sample which comprises adding a signal substrate to said sample, said signal substrate causing a detectable signal related to the... Agent: Kalow & Springut LLP

20100105092 - Lipolytic enzyme variants: Variants with increased acyl transferase activity can be designed on the basis of a three-dimensional model by making amino acid alterations near the active Ser of lipolytic enzymes such as C. antarctica lipase A or the lipase/acyl transferase from C. parapsilosis.... Agent: Novozymes North America, Inc.

20100105093 - Assay method for the detection of viable microbial cells in a sample: The present invention discloses an assay method for the detection of viable microbial cells in a sample, the assay method comprising the steps of: i) adding an ATP degrading enzyme to a sample suspected of containing viable microbial cells to substantially degrade any extracellular ATP in the sample; ii) adding... Agent: 3m Innovative Properties Company

20100105094 - Method, device and apparatus for measuring the concentration of creatinine, and method, device and apparatus for measuring the amount of salt in urine using the same: A method for measuring the concentration of creatinine includes the steps of: (A) mixing a sample containing creatinine with a creatinine quantitative reagent including 1-methoxy-5-methylphenazinium in the absence of picric acid and any enzyme responsive to creatinine, to cause the creatinine to reduce the 1-methoxy-5-methylphenazinium; (B) electrochemically or optically measuring... Agent: Mcdermott Will & Emery LLP

20100105096 - Method of evaluating foam-holding property of fermented malt drink and marker for evaluating foam-holding: The present invention provides a method for determination of the foam stability of a fermented malt beverage, wherein the concentration of yeast thioredoxin (MT) in the fermented malt beverage or a fermenting material solution of the fermented malt beverage is used as an index having a negative correlation with the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100105095 - Optical molecular sensors for cytochrome p450 activity: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the... Agent: Life Technologies Corporation C/o Intellevate

20100105102 - Device, method and apparatus for analyzing skin and hair: The present invention includes compositions, methods, and systems for the analysis of skin and hair conditions. The system includes a method and apparatus for analyzing skin and hair samples by taking a sample, identifying desired components of the sample, obtaining an image electronically, storing the image, and analyzing the image... Agent: Chalker Flores, LLP

20100105101 - Methods for the diagnosis and risk assessment of plasmalogen deficiency mediated diseases of aging: The present invention relates to methods for the diagnosis and risk assessment of plasmalogen deficiency mediated diseases of aging. The present invention describes the relationship between plasmalogen biosynthesis dysfunction and the biochemical and clinical manifestations of age related disorders. Specifically the present invention describes an increased prevalence of colon cancer,... Agent: Nixon Peabody LLP - Patent Group

20100105098 - Methods of identifying disease biomarkers in the lense of the eye: The present invention relates to methods for the early diagnosing of an amyloid-related disorder or a predisposition thereto in a subject through the detection or monitoring of a metal-protein complex in the ocular lens, wherein said metal-protein complex comprises at least one amyloid protein.... Agent: Klauber & Jackson

20100105100 - Multipotent/pluripotent cells and methods: Described herein are multipotent stem cells, e.g., human and other mammalian pluripotent stem cells, and related methods.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100105099 - Tri-functionalized cryptophane, synthesis and uses thereof: This invention relates to biosensors with improved solubility and affinity to a noble element. Specifically, the invention relates to methods and systems for the detection of target entities using the signal observed in a noble element complexed to the biosensor.... Agent: Pearl Cohen Zedek Latzer, LLP

20100105097 - Two-photon probe for real-time monitoring of intracellular calcium ions, method for preparing the probe and method for real-time monitoring of intracellular calcium ions using the probe,: A two-photon probe for real-time monitoring of intracellular calcium ions is provided. The two-photon probe is very suitable for real-time imaging of intracellular calcium ions, shows 20-5 O-fold TPEF enhancement in response to Ca2+, has a dissociation constant (Kdτp) of 0.14±0.02 to 0.25±0.03 μM, and emits 5-fold stronger TPEF than... Agent: Alston & Bird LLP

20100105103 - Alcohol tolerant escherichia coli and methods of preparation thereof: The present invention relates to E. coli mutants, which have enhanced alcohols tolerance and can be used in production of alcohols through fermentation. The present invention also provides a novel method to prepare the alcohol-tolerant E. coli strains.... Agent: Wpat, PC Intellectual Property Attorneys

20100105104 - Chip for sampling cell component, system for analyzing cell component and method of analyzing cell component using the same: The present invention provides a method, a chip device, and a system for quantitatively measuring intercellularly and intracellularly-localized mRNA and protein without loss of local space information. In the present invention, cell content is trapped atop a substrate or an electrode in the form of a two-dimensional projection of a... Agent: Sughrue Mion, PLLC

20100105105 - Use of a reference source with adaptive optics in biological microscopy: Methods of microscopic imaging of biological tissue using adaptive optics technology to improve the image focus and sharpness. Wavefront measurements are taken by using a novel method of seeding biological tissue by using a fluorescent microsphere as a “guide star” as a natural point-source reference. The current methods are capable... Agent: Bell & Associates

20100105108 - Method and device for producing vaccine: A method of making a vaccine using animal derived component free (ADCF) cell culture technology, including the steps of attaching ADCF-adapted cells to a microcarrier including an attachment mechanism for attaching filipodia of the cells, the microcarrier being in a culture, growing the cells in ADCF maintenance media, infecting the... Agent: Shook, Hardy & Bacon LLP Intellectual Property Department

20100105106 - Preparation and uses of gene sequences encoding chimerical glycosyltransferases with optimized glycosylation activity: The present invention relates to the production of gene sequences encoding chimerical membrane glycosyltransferases presenting an optimized glycosylation activity in cells transformed with said sequences, said gene sequences corresponding to the fusion: of a first nucleic acid coding for a C-terminal minimal fragment of the catalytic domain (CD) of the... Agent: Young & Thompson

20100105107 - Purification and characterization of soluble mhc proteins: The present invention relates generally to the production and use of functionally active soluble HLA molecules that are isolated and purified substantially away from other proteins, and methods of purifying same.... Agent: Dunlap Codding, P.C.

20100105109 - Multiply-primed amplification of circular nucleic acid sequences: Improved processes for the amplification of target DNA sequences in the form of single or double stranded circular DNA molecules, especially those present in colony and plaque extracts, using multiple specific and/or random sequence oligonucleotide primers are disclosed. The product of this amplification is used for analysis by restriction enzyme... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100105110 - Method of adenoviral vector synthesis: This invention provides methods for adenoviral vector synthesis. The present invention further provides methods for binding adenovirus terminal protein obtained from virus to linear DNA. The present invention further provides a recombinant adenovirus from which the adenovirus terminal protein can be purified with an inverted terminal repeat DNA sequence.... Agent: Xavier Danthinne O.d.260 Inc.

20100105111 - Method for production of optically active amino acid: An optically active amino acid is useful as food or feed, agrochemicals, chemical products for industrial use, intermediates for synthesis of cosmetics or medicines and the like and is also important as optical resolving agents or chiral building blocks for use in organic synthesis. Thus, the object is to provide... Agent: Fitch, Even, Tabin & Flannery

20100105112 - Fluorocarbon emulsion stabilizing surfactants: Surfactants (e.g., fluorosurfactants) for stabilizing aqueous or hydrocarbon droplets in a fluorophilic continuous phase are presented. In some embodiments, fluorosurfactants include a fluorophilic tail soluble in a fluorophilic (e.g., fluorocarbon) continuous phase, and a headgroup soluble in either an aqueous phase or a lipophilic (e.g., hydrocarbon) phase. The combination of... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100105113 - Method for production of dha-containing phospholipid through microbial fermentation: Disclosed is a method for producing a DHA phospholipid comprising an ω3 unsaturated fatty acid, particularly DHA, as a constituent lipid by using a microorganism in a simpler manner. Specifically disclosed is a method for producing a phospholipid comprising an ω3 unsaturated fatty acid as a constituent lipid, which comprises... Agent: Quinn Emanuel Koda & Androlia

20100105115 - Alcohol production process: The invention relates to biological processes for producing one or more desired products, including alcohols such as ethanol and butanol. The processes comprise carrying out first and second fermentations of substrates in first and second bioreactors, wherein each fermentation produces one or more desired products and/or one or more by-products... Agent: Occhiuti Rohlicek & Tsao, LLP

20100105114 - Methods and compositions for regulating sporulation: Methods and compositions are provided for producing fuel utilizing various strains of Clostridium phytofermentans with reduced sporulation activity. In some embodiments, the activity of a gene associated with sporulation is reduced. In some embodiments, a fuel producing strain of C. phytofermentans with reduced sporulation activity is provided.... Agent: Fish & Richardson PC

20100105116 - Bioconversion process using liquid phase laving to enhance gas phase conversion: The bioconversion of gas feedstreams to liquid products by direct contact with a layer of microorganism obtains enhanced productivity through the regular cycling of liquid across a substrate that supports a biolayer of microorganisms while separating the gas and liquid phases. Such processes produce liquid products such as ethanol, butanol... Agent: Cardinal Law Group

20100105117 - Gene associated with foam formation of acetic acid bacterium, acetic acid bacterium bred by modifying the gene and method for producing vinegar using the acetic acid bacterium: The object of the present invention is to provide a method for suppressing foam formation by identifying a gene involved in foam formation during culture of an acetic acid bacterium and reducing or deleting the function of a protein encoded by the gene, a method for more efficiently producing vinegar... Agent: Chalker Flores, LLP

20100105118 - Process for the production of alcohols: The present invention relates to a process for the production of one or more C2+ alcohols. In particular, the present invention relates to a process for the production of C2+ alcohols from a methane-containing feedstock, which process comprises: a. Passing said methane-containing feedstock and carbon dioxide to a non-oxidative reforming... Agent: Nixon & Vanderhye, PC

20100105119 - Processing materials: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems are described that can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy materials, to produce ethanol and/or butanol, e.g., by fermentation. Hydrocarbon-containing materials are also... Agent: Xyleco, Inc. Celia Leber

20100105120 - Photocleavable sense-antisense complex: There is disclosed a photocleavable sense-antisense nucleobase polymer complex capable of modulating gene expression comprising an unnatural antisense nucleobase polymer that targets an mRNA, and a photocleavable sense nucleobase polymer noncovalently bound to the antisense nucleobase polymer, wherein the photocleavable sense nucleobase polymer comprises a plurality of nucleobase polymers connected... Agent: Syntrix Biosystems, Inc.

20100105121 - Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon: Provided herein is are polypeptides that include the protease domain of a type II transmembrane serine protease (MTSP) as a single chain. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP are provided. Also provided are MTSPs designated MTSP3 and MTSP4 and a form... Agent: K&l Gates LLP

20100105122 - Oncolytic viruses as phenotyping agents for neoplasms: The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For example, reovirus does not replicate in normal cells. However, reovirus selectively replicate in cells with an activated ras pathway, which leads to death... Agent: Fish & Richardson P.C.

20100105123 - Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same: The invention relates to a scleroprotein of an adeno-associated virus which contains at least one mutation. Said mutation causes the chromatographic properties to be modified. The invention also relates to the production of said scleroprotein and the use thereof.... Agent: Clark & Elbing LLP

20100105124 - Novel method for the production and purification of adenoviral vectors: The present invention relates to improved methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.... Agent: Fulbright & Jaworski L.L.P.

20100105126 - Method and apparatus for extracting carbon dioxide from air: A method and apparatus for extracting CO2 from air comprising an anion exchange material formed in a matrix exposed to a flow of the air, and for delivering that extracted CO2 to controlled environments. The present invention contemplates the extraction of CO2 from air using conventional extraction methods or by... Agent: Hayes Soloway P.C.

20100105125 - Systems, apparatuses and methods for cultivating microorganisms and mitigation of gases: Systems, apparatuses, and methods are provided for cultivating microorganisms. In one example, a system may include a plurality of containers for cultivating microorganisms therein. Each container may be adapted to contain water and may include media disposed therein and at least partially submerged in the water. The media may be... Agent: Wildman Harrold Allen & Dixon LLP

20100105127 - Systems and methods for generating resources using wastes: Systems and methods for generating resources using municipal solid waste are disclosed herein. According to one aspect, a method includes receiving wastes. The wastes can be separated into different portions for different downstream processes. Further, the wastes can be treated in an anaerobic digestion process for producing biogas. A gasification... Agent: Olive Law Group, PLLC

20100105128 - Portable high rate anaerobic digester apparatus and method of operation: An apparatus for digesting waste includes a digester tank, a drainage trough located near a top of the digester tank, an auger located inside the drainage trough, and a skimmer that pushes waste into the drainage trough.... Agent: Foley & Lardner LLP

20100105129 - Biomass production system: A system preferably for light irradiation, wherein the system includes a support structure, wherein the support structure is able to accommodate an array of vessels capable of receiving light; the system includes a buoyancy support system and a feeding harvesting system, wherein the buoyancy support system is in fluid and... Agent: Lambert & Associates, P.l.l.c.

20100105131 - Circulatory packed bed reactor: An improved circulatory packed bed reactor includes a fermentor, a ventilation system communicating with the fermentor through pipes, and a circulatory system. The fermentor has an upper pipe joint and a lower pipe joint. The circulatory system includes a pipe device and a cell-fixation device. The pipe device includes a... Agent: Scihead Intellectual Property Law Group, Ltd

20100105130 - Reaction container plate and its reaction processing equipment: Intrusion of foreign matters from the outside of a reaction container plate and environmental contamination onto the outside are prevented. The reaction container plate (1) comprises a container base (3) having a reaction container (5), a channel base (11) having an introduction hole (11b) above the reaction container (5) and... Agent: Cheng Law Group, PLLC

20100105132 - Human mesenchymal stem cells and preparation thereof: The present invention provides a process of isolation, proliferation and/or maintenance of mesenchymal stem cells (MSCs). The invention further provides a culture medium for proliferation and/or maintenance of human mesenchymal stem cells in xeno-free conditions. The culture medium provided in the present invention proliferates and/or maintains mesenchymal stem cell expansion... Agent: Schwegman, Lundberg & Woessner, P.A.

20100105134 - Nucleic acid compounds for inhibiting gene expression and uses thereof: The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), and blunt ended double-stranded ribonucleic acid molecules capable of decreasing or silencing expression of a target gene. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions... Agent: Schwabe, Williamson & Wyatt, P.C.

20100105133 - Somatic cells for use in cell therapy: The present invention generally concerns cell therapy and products for use in such therapy. Particularly, the invention provides a preserved cell preparation essentially free of one or more members of a group of cryoprotecting agents consisting of polyalcohols, DMSO and cryoprotecting proteins, the preserved cell preparation comprising somatic cells and... Agent: The Nath Law Group

20100105135 - Porous membrane device that promotes the differentiation of monocytes into dendritic cells: Dendritic cells (DCs) for research and clinical applications are typically derived from purified blood monocytes that are cultured in a cocktail of cytokines for a week or more. Because it has been suggested that these cytokine-derived DCs may be deficient in some important immunological functions and might not accurately represent... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100105136 - Chimeric t-cell receptors and t-cells targeting egfrviii on tumors: Chimeric T-cell receptor proteins have been produced in cells by the construction of nucleic acids and vectors, and the transfection of the vectors into cells. The chimeric proteins comprise, as an extracellular binding portion, a single chain antibody portion that binds to EGFRvIII, a transmembrane portion derived from human CD8α... Agent: David S. Resnick

20100105137 - Method for induction/differentiation into photoreceptor cell: The present invention provides a method of producing primate retinal progenitor cells, comprising culturing primate embryonic stem cells as suspended aggregates in a serum-free medium, and obtaining retinal progenitor cells from the culture. The present invention further provides a method of producing photoreceptor precursor cells, comprising culturing isolated retinal progenitor... Agent: Leydig Voit & Mayer, Ltd

20100105138 - Premounted fluid conveyance assembly for cell expansion system and method of use associated therewith: A premounted fluid conveyance assembly for use with a cell expansion machine comprises a tubing-organizer and a fluid conveyance system. The fluid conveyance system is at least partially attached to the tubing-organizer, and the fluid conveyance system comprises an oxygenator or gas transfer module, a length of tubing and a... Agent: Holme Roberts & Owen LLP

20100105139 - Ligand targeted nanocapsules for the delivery of rnai and other agents: A carrier system for the delivery of therapeutic and/or diagnostic agents is described. The carrier system is comprised of ligands and a biodegradable polycation for complexing polyanionic molecules such as RNAi, said polycation forming a coating on the outer surface of anionic or neutral liposomes. Also disclosed is a method... Agent: Maurizio Cattaneo

20100105140 - Plaice dna transposon system: This document describes the Passport transposon system and methods of making and using the same.... Agent: Dardi & Herbert, PLLC

20100105141 - Sulfonylurea-responsive repressor proteins: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms... Agent: Pioneer Hi-bred International, Inc.

  
04/22/2010 > patent applications in patent subcategories. category listing, related patent applications

20100099074 - Collection device and method for stimulating and stabilizing a biological sample: A collection device and methods for stimulating and stabilizing a biological sample are provided. Aspects of the device include an evacuated sample collection container having stimulating and stabilizing additives contained in separate internal chambers of the container. The internal chambers are arranged to facilitate stimulation upon collection of a sample,... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20100099075 - Semen manipulation process: The present invention refers to a semen manipulation process that aims at separating spermatic cells from their maintenance medium. The process the invention deals with allows for an increase in the final concentration of the obtained sperms and for an increase in the production indexes of in vitro embryos, presenting... Agent: Alston & Bird LLP

20100099078 - Method for designing a drug regime for hiv-infected patients: The instant disclosure describes a novel genotype and phenotype assay to elucidate and/or evaluate new potential HIV integrase inhibitors, but also currently approved and experimental compounds that target protease, reverse transcriptase, and RNaseH. This assay allows studying linked mutations and mutational patterns that occur under HAART and experimental therapies.... Agent: Philip S. Johnson Johnson & Johnson

20100099079 - Non-dividing cell-based assay for high throughput antiviral compound screening: The present invention features a cell-based assay that recapitulates all aspects of a viral lifecycle for use in identifying antiviral agents. The assay employs synchronized, non-dividing host cells and a fluorescence resonance energy transfer peptide substrate for monitoring endogenous viral protease activity, which is indicative of viral infection kinetics.... Agent: Licata & Tyrrell P.C.

20100099076 - Sensitive and rapid detection of viral particles in early viral infection by laser tweezers: The present system and methods allow for low level detection of as little as single pathogen particles, such as viral or bacterial particles, during the early stage of infection. An optical trapping system, such as laser tweezers, are used to trap a substrate to which an analyte has been bound... Agent: Hahn Loeser & Parks, LLP

20100099077 - Stable acridinium esters with fast light emission: Chemiluminescent acridinium esters are provided which are fast light emitting and hydrolytically stable. The chemiluminescent acridinium esters are useful labels in assays for detecting or quantifying analytes.... Agent: Siemens Corporation Intellectual Property Department

20100099100 - 'ultra-high multiplex analytical systems and methods\": Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection... Agent: Pacific Biosciences Of California, Inc.

20100099097 - A flow through system, flow through device and a method of performing a test: The invention relates to a flow through system for quantifying a target component in a liquid. The flow through system comprises a flow-through device comprising a flow path comprising a marker section, a capture section downstream to said marker section, and at least two quantification sections. The marker section comprises... Agent: Buchanan, Ingersoll & Rooney PC

20100099082 - Allele detection: Method for simultaneously determining alleles present in a set of loci from at least one nucleic acid sample comprising the steps: a) providing said at least one sample, b) subjecting said sample to a nucleic acid amplification reaction using a primer pair simultaneously primer pairs specific and optimized for each... Agent: Fulbright & Jaworski L.L.P.

20100099110 - Allele-specific amplification: The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having a 3′-terminal nucleotide complementary to only one variant of the target sequence and having at least one nucleotide with a base covalently... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100099111 - Antibodies against a protein entitled 161p2f10b: Antibodies and methods of using same against products of the gene designated 161P2F10B and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target... Agent: Agensys C/o Morrison & Foerster LLP

20100099105 - Antibodies having binding specificity for the extracellular domain of a breast cancer resistance protein (bcrp): The present invention includes methods of identifying and/or isolating stem cells based on expression of BCRP. The present invention also describes methods of obtaining and/or using cell populations enriched for stem cells. In addition, methods are provided for diagnosing and/or prognosing leukemia, particularly human acute myelogenous leukemia (AML), through assaying... Agent: St. Jude Children''s Research Hospital C/o Darby & Darby P.C.

20100099103 - Antibody libraries: The present invention features improved in vitro RNA display libraries to allow reliable expression and selection of scFv antibody molecules from expression libraries. The scFv antibody libraries of the invention contain an optimized, shortened inter-domain linker that improves expression scFv antibody expression. The scFv antibody libraries also include short nucleic... Agent: Lahive & Cockfield, LLP/abbott Floor 30, Suite 3000

20100099090 - Biomarkers and methods for determining sensitivity to ctla-4 antagonists: CTLA-4 biomarkers useful in a method for predicting the likelihood that a mammal that will respond therapeutically to a method of treating cancer comprising administering an CTLA-4 antagonist, wherein the method comprises (a) measuring in the mammal the level of at least one biomarker s, (b) exposing a biological sample... Agent: Louis J. Wille Bristol-myers Squibb Company

20100099093 - Biomarkers for the identification monitoring and treatment of head and neck cancer: This present invention compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100099106 - Cell death inhibitor: The cell death inhibitor comprising a substance capable of binding to macrophage migration inhibitory factor is useful as a preventive/therapeutic agent for, e.g., heart diseases, neurodegenerative diseases, cerebrovascular diseases, central nervous infections, traumatic diseases, demyelinating diseases, bone/joint diseases, kidney diseases, liver diseases, myelodysplastic diseases, arteriosclerosis, diabetes, pulmonary hypertension, sepsis, inflammatory... Agent: Edwards Angell Palmer & Dodge LLP

20100099096 - Compositions and methods for identifying factors affecting protein stability: The present invention is directed to retroviral vectors, and libraries generated from the vectors that can be used in assessing the stability of proteins and in correlating degradation with a specific E3 ubiquitin ligase. The libraries can also be used to identify factors that alter the degradation of proteins of... Agent: Law Office Of Michael A. Sanzo, LLC

20100099083 - Crohn disease susceptibility gene: The present invention relates to the ATG16l1 gene and genetic variants associated with Crohn's disease. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug... Agent: Dowell & Dowell P.C.

20100099084 - Detection of npm1 nucleic acid in acellular body fluids: The present inventions relates to methods for detecting NPM1 nucleic acid in acellular body fluid samples and determining whether the nucleic acid contains one or more mutations including insertions and deletions. The methods are useful for predicting prognosis of AML patients that have cells with mutations in the NPM1 gene.... Agent: Foley & Lardner LLP

20100099102 - Development of diagnostic markers from the saliva of head and neck cancer patients: The present invention relates to biomarkers that are useful for the detection of cancer. The invention further relates to biomarkers and methods of using biomarkers for the early detection of head and neck cancer.... Agent: Hogan & Hartson L.L.P.

20100099087 - Gene sequence variances in genes related to folate metabolism having utility in determining the treatment of disease: The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods of treatment of a disease or condition. The variance information is indicative of the expected response of a patient to a method... Agent: Sheridan Ross PC

20100099091 - Genetic component of complications in type 2 diabetes: The invention provides with means to predict, in subjects affected by type 2 diabetes (T2D), the probability of developing complications related to the disease. The invention involves 1) use of genetic features (SNPs, STRs, or other genomic markers) together with other chromosomal features and phenotypic information to establish a patient... Agent: Millen, White, Zelano & Branigan, P.C.

20100099104 - Genetic test for the identification of carriers of complex vertebral malformations in cattle: Genetic markets for identifying bovine carriers of complex vertebral malformation (CVM) disease gene are described. The genetic markers, including the microsatellite markers, BM4129, INRAA003, BMS2790, ILSTS029, INRA123, BM220, HUJ246, BMS862, BMS937, BL1048, BMS2095 and BMS1266 and the bovine SLC35A3 gene, are located on bovine chromosome BTA3. The G/T polymorphism at... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100099086 - Method and apparatus for determining a probability of colorectal cancer in a subject: A method of determining a probability that a human test subject has colorectal cancer as opposed to not having colorectal cancer is disclosed. The method comprises, for each gene of a set of one or more genes selected from the group consisting of ANXA3, CLEC4D, IL2RB, LMNB1, PRRG4, TNFAIP6 and... Agent: Edwards Angell Palmer & Dodge LLP

20100099099 - Method and test kit for the rapid detection of specific nucleic acid sequences, especially for detecting of mutations or snps: A method and a test kit for rapid detection of specific nucleic acid sequences, especially for detection of mutations or single nucleotide polymorphisms (SNPs), in which the detection reaction takes place in two steps. The first step involves the target-specific amplification reaction, coupled with the probe-hybridization reaction using fluorescence-labeled allele-specific... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100099108 - Method for detecting, isolating, and characterizing cells from body samples by transfection with nucleic acid constructs: A method for detecting or isolating disease-associated cells or pluripotent stem cells from body samples is provided where cells of a body sample are transfected with nucleic acid constructs that include the following components: (a) a promoter element containing at least one DNA site for binding one or more transcription... Agent: Siemens Corporation Intellectual Property Department

20100099107 - Method for identifying an intestinal phenotype: The present invention relates to a method for identifying cells having a predisposition to develop an intestinal phenotype, wherein the cells are characterized by the loss of expression of the RUNX3 gene and the expression of one or more intestinal marker genes. In particular, the invention is directed to the... Agent: Foley & Lardner LLP

20100099081 - Method for typing hla alleles: The present invention relates to the typing of HLA alleles. The sequence of exon 2 and exon 3 of the alleles HLA-B*3913, HLA-B*1406 and HLA-B*51 new and of exon 2 of the alleles HLA-DRB1*0820, HLA-DRB1*04 new and HLA-DRB4*01 new are disclosed. The present invention relates to methods for typing of... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100099094 - Method of detecting nucleic acid amplification reaction: The present invention provides a method of detecting a nucleic acid amplification reaction, including the steps of adding a sample nucleic acid to a nucleic acid amplification buffer containing a reducing agent molecule, a redox molecule and a magnesium ion, to conduct an amplification reaction, measuring a reduction current produced... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100099098 - Methods and compositions for diagnosing and monitoring transplant rejection: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also... Agent: Morrison & Foerster LLP

20100099109 - Methods for analyzing drug response: The present invention provides methods, instruments, reagents, kits and the biology involved in analyzing drug response. An embodiment of the present invention provides an approach for the characterization a plurality of pathways in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on... Agent: Wilson, Sonsini, Goodrich & Rosati / Nodality, Inc

20100099092 - Methods for determination of haplotype dissection: A method for molecular haplotyping of a subject is disclosed. The method comprises: randomly selecting a set of chromosomes in each of a plurality of lyzed diploid cells of the subject, collecting the selected chromosomes from said plurality of cells into a plurality of sample tubes, wherein each sample tube... Agent: Morris Manning Martin LLP

20100099095 - Methods for determining prognoses and therapeutic interventions for ovarian carcinomas: Methods for determining the prognosis and therapeutic interventions for cancer and for utilizing the expression of the homeoprotein Six1 to determine the prognosis and therapeutic interventions for cancer, in particular for ovarian carcinomas.... Agent: Snell & Wilmer L.L.P. (main)

20100099101 - Methods for treating, diagnosing, and monitoring lupus: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveness to lupus therapeutic agents.... Agent: Genentech, Inc.

20100099080 - Nucleic acid memory device: This invention pertains to methods of imparting information onto nucleic acid sequences. In specific embodiments, the present invention provides site-specific recombinase systems and error-prone polymerase systems to alter nucleotide sequences such as DNA and mini-genomes, as well as for the production of microarrays. The present invention also provides methods of... Agent: Banner & Witcoff, Ltd.

20100099088 - Reliable detection of vancomycin-intermediate staphylococcus aureus: The present invention relates to a method for identifying a VISA strain in a sample comprising measuring SAV2095 expression levels, a kit and use of SAV2095 for same. The present invention also relates to a method for facilitating the development of an individualized treatment regimen comprising measuring the expression level... Agent: Goodwin Procter LLP Patent Administrator

20100099089 - Reporter unit for detection of target molecules using polymerisable substrate: The invention relates to a reporter unit for detecting a target molecule comprising at least one component attached to a target molecule specific probe, wherein said at least one component is liberated from said probe by the activity of a first enzyme thereby making the at least one component available... Agent: The Nath Law Group

20100099085 - Serum dna methylation screening for cancer: We disclose a method of screening a mammal for a cancer associated with methylation of promoters of tumor-suppressor genes by collecting a sample of a body fluid or tissue of the mammal containing free DNA; isolating the free DNA from the sample; amplifying at least a portion of the promoter... Agent: Williams, Morgan & Amerson

20100099114 - Analytical strip and detecting method using the same: An analytical strip and a detecting method using the analytical strip are provided. The analytical strip includes a substrate having a channel thereon. The channel has a first region, a second region and a third region, which are arranged successively. A first antibody is localized in the first region. A... Agent: Sinorica, LLC

20100099117 - Diagnostic method for determining the susceptibility to delivery and reagent kit for use therefor: The invention relates to a diagnostic method for detecting susceptibility to delivery, and to a test kit for this purpose. A low, but higher than baseline level concentration of Insulin-like Growth Factor Binding Protein 1 (IGFBP-1), which is due to leakage from decidual cells, is detected by an immunological assay... Agent: Birch Stewart Kolasch & Birch

20100099116 - Methods for analysis of hedgehog pathway inhibitors: One aspect of the present invention relates to a method of ascertaining the inhibitory activity in a mammal of a candidate inhibitor of the hedgehog pathway. In certain embodiments, the candidate inhibitor is administered systemically. In certain embodiments, the mammal is a rodent or primate. In certain embodiments, the mammal... Agent: Foley Hoag, LLP (w/ipx)

20100099113 - Minimized small peptides with high affinity for factor viii and factor viii-like proteins: The present invention relates to the composition of small molecules and their use in the field of protein isolation, purification, stabilizing and/or enhancing its activity. In particular, the present invention relates to the synthesis and optimization of compounds comprising small peptides and peptide derivatives with affinity to coagulation Factor VIII... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100099112 - Quantitative lateral flow system and assay: The present invention relates to a lateral flow assay and system, including a test strip, for detection and quantification of analytes in samples, such as samples containing cells and fluid, where the assay is volume independent, and the sample size is less than about 100 μl, where the test strip... Agent: Global Patent Group - Rla

20100099115 - Systems and methods for preparing and analyzing samples: The invention relates to systems and methods for preparing and analyzing samples (e.g., mucosal samples) for a microorganism of interest. In particular, the systems and methods are useful for detecting one or more analytes characteristic of a microorganism (i.e., microbe) of interest, such as components of cell walls that are... Agent: 3m Innovative Properties Company

20100099121 - Method for the diagnosis of cancers by measuring the changes of glycosylation of proteins related to tumorigenesis and metastasis and kit for diagnosis of cancers using the same: The present invention relates to a method for diagnosing cancers by measuring proteins associated with tumorigenesis and metastasis, and a diagnostic kit using the same, particularly relates to the method for diagnosing cancers by measuring the changes of glycosylation of proteins and the kit for diagnosis of cancers using the... Agent: Klarquist Sparkman, LLP

20100099122 - Ferric reductase activity of histoplasma capsulatum y-glutamyltransferase: A novel gamma-glutamyltransferase gene and its encoded protein isolated from the fungus Histoplasma capsulatum are disclosed. The gene and protein are useful as novel fungicidal targets, or as research tools for conducting a new mode of glutamyl transfer and iron reduction. Compositions and methods that use the genes and proteins... Agent: Warf/bhgl

20100099119 - Detecting a bacterial process in chronic rhinosinusitis: The present invention provides a method for identifying bacterial induced rhinosinusitis. The method comprises obtaining a nasal or paranasal mucus sample and detecting the presence of neutrophil degranulation in the mucus sample. Degranulation of neutrophils can be determined by morphological analysis of the cells in the mucus or by detection... Agent: Hodgson Russ LLP The Guaranty Building

20100099118 - Methods of determining total pon1 level: e

20100099120 - Method for staining substances having a phosphate group: It is intended to provide a method by which a substance having a phosphate group can be easily detected from a biological sample or the like, a method by which a phosphorylated amino acid residue is easily identified and a compound which can be used in the methods because of... Agent: Frishauf, Holtz, Goodman & Chick, PC

20100099124 - Method for diagnosing diseases based on levels of anti-glycan antibodies: Disclosed are methods for diagnosing Crohn's disease (CD) or anti-phospholipid syndrome by measuring levels of antibodies to glycans in a biological sample.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100099123 - Soluble human m-csf receptor and uses thereof: Soluble human M-CSF receptor is provided, along with pharmaceutical compositions containing such receptor, kits containing a pharmaceutical composition, and methods of diagnosing and treating diseases and disorders associated with M-CSF such as bone loss in a subject afflicted with an osteolytic disease.... Agent: Marshall, Gerstein & Borun LLP

20100099125 - Method for measuring low-density lipoprotein (ldl) cholesterol and test piece for measuring ldl cholesterol: An LDL cholesterol measurement method that can be used with a test piece is provided. The LDL cholesterol measurement method for measuring LDL cholesterol in a sample has (A) a step of providing a total-cholesterol measurement portion and a non-LDL cholesterol measurement portion for measuring non-LDL cholesterol, which is cholesterol... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100099126 - Method of calculating enzymatic reaction rate, computer program product and method of determining amount of enzyme in sample: A method of calculating an enzymatic reaction rate using the largest frequency value of a slope of a sub-group, a computer program product capable of performing the method of calculating an enzymatic reaction rate, and a method of determining the amount of an enzyme in a sample are provided.... Agent: Sughrue Mion, PLLC

20100099127 - System and method for acquiring and storing biological samples: A system and method that may include grasping a sample collection medium with a holder; inserting the sample collection medium into a medium storage device within a first container such that at least a first portion of the sample collection medium is securely held within the first container; separating a... Agent: Kaplan Gilman & Pergament LLP

20100099128 - Novel peptidase substrates: s

20100099132 - Bacterial growth inducer: The present invention relates to methods of preparing bacterial growth inducers, and in particular to novel bacterial growth inducers/resuscitators prepared by such methods. The invention extends to various applications of such growth inducers, for example in clinical and environmental diagnostics, in reviving not immediately culturable (NIC) bacteria, and in the... Agent: Nixon Peabody LLP - Patent Group

20100099133 - Method and apparatus for the treatment of specimens: A method and an apparatus for the treatment of cytological and histological specimens are described. A treatment program comprising multiple treatment parameters is predetermined. The specimens are introduced in accordance with the predetermined treatment program sequentially into a plurality of treatment stations by means of a transport device. At least... Agent: Alexander R Schlee SchleeIPInternational P.C.

20100099135 - Methods and assays for assessing the quality of embryos in assisted reproduction technology protocols: The present invention provides methods and assays for assessing the presence, viability and/or developmental stage of an embryo. The present invention also provides method and assays for assessing the quality of an Assisted Reproduction Technology protocol.... Agent: Foley & Lardner LLP

20100099130 - Methods and devices for monitoring platelet function: A method of monitoring platelet function comprising: passing blood removed from a mammal through a passageway comprising (i) a shear generating restriction to generate a platelet mass in the passageway and (ii) a platelet aggregate trap; and monitoring the flow or composition of the blood in the passageway to detect... Agent: Popovich, Wiles & O'connell, Pa

20100099134 - Methods for detecting sulfhydryl-containing compounds in a biological test sample: m

20100099136 - Microfluidic assay for selection and optimization of drug delivery vehicles to tumors: An apparatus and method for assaying a tumor drug delivery vehicle comprises a synthetic microvascular network of interconnected flow channels in fluid communication through a porous wall with a tissue space containing animal cells and means for quantifying drug delivery from the microvascular network to the animal cells.... Agent: Tomas Friend, LLC

20100099131 - Solution of matrix: A solution of a matrix contains a liquid mixture consists of acetonitrile and water as main solvent component, wherein a volumetric ratio of acetonitrile and water is within a range of from acetonitrile 6.5: water 3.5 to acetonitrile 8: water 2, and wherein sinapinic acid is contained as the matrix.... Agent: Mcginn Intellectual Property Law Group, PLLC

20100099129 - Transcobalamin ii assay method: An assay method for determining transcobalamin saturation wherein a transcobalamin containing liquid sample is contacted with a porous substrate with immobilized thereon a transcobalamin immobilizing ligand and with a reporter-labelled transcobalamin binding partner and wherein signals from reporter labels which become immobilized on said substrate are detected, characterised in that... Agent: Bacon & Thomas, PLLC

20100099137 - Direct antimicrobial susceptibility assay: An antimicrobial susceptibility assay, including an assay dish including at least one chamber, at least one growth medium carried by the assay dish, at least one antimicrobial agent sample positionable at a sample location adjacent a growth medium in the assay dish, at least one interpretive indication positionable at a... Agent: Read R. Taintor

20100099138 - Multiple-valent opsonophagocytic assay selection panel arrays and uses therefor: This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the method uses a metabolic colorimetric indicator to determine if viable bacteria are present. Also disclosed are arrays that can be used to determine the viability of... Agent: Klarquist Sparkman, LLP

20100099139 - Means and methods for detecting bacteria in a sample: The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample. The method comprises steps selected inter alia from (a) obtaining an absorption spectrum (AS) of said uncultured sample; (b) acquiring the n dimensional volume boundaries for said specific bacteria; (c) data processing said AS;... Agent: Fleit Gibbons Gutman Bongini & Bianco Pl

20100099140 - Methods and compositions for preventing artifacts in tissue samples: Methods and compositions for preventing artifacts in tissue samples fixed with an aldehyde-based fixative are described. The methods include fixing a tissue sample with an aldehyde-based fixative, such as a formalin fixative agent. After fixation, the tissue sample can be contacted with separate solutions that each contain an artifact preventing... Agent: Kirton And Mcconkie

20100099141 - Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds: The present invention relates to a method for preparing 2-alkoxy and 2-aryloxyestrogen compounds, and the intermediate compounds prepared during the use of this method, which intermediate compounds are useful intermediates in the preparation of certain physiologically active compounds.... Agent: Modiano & Associati

20100099142 - Processing of peptides and proteins: The invention provides novel methionine aminopeptidase enzymes and their use.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20100099143 - Alanine 2,3-aminomutases and related polynucleotides: The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides... Agent: Dechert LLP

20100099144 - Combined use of cell permeable nanog and oct4 for increasing self-renewal and suppressing differentiation of stem cells: The present invention discloses cell permeable Nanog and Oct4 recombinant proteins that comprise a kaposi fibroblast growth factor 4 (kFGF4)-derived macromolecule transduction domain (MTD). Also disclosed are polynucleotides encoding the cell permeable Nanog and Oct4 recombinant proteins, a method of increasing self-renewal and suppressing differentiation of stem cells by treating... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100099145 - Recombinant human epo-fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo: A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo... Agent: Oyen, Wiggs, Green & Mutala LLP 480 - The Station

20100099146 - Variants of beta-glucosidases: The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1... Agent: Novozymes, Inc.

20100099147 - Anti-igf-1r antibodies and uses thereof: The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-1R-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20100099148 - Novel vectors for production of antibodies: Novel compositions for the production of the light and heavy chains of an antibody are provided. These novel compositions are also used to produce germline transgenic birds that can successfully pass the transgene encoding the antibody to their offspring. The compositions comprise components of vectors, such as a vector backbone,... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20100099149 - Stabilizing compositions and methods for extraction of ribonucleic acid: The present invention provides a composition and method for stabilizing ribonucleic acid (RNA) from biological samples such that the ribonucleic acid within the sample remains stable at room temperature. The composition comprises an anionic detergent and a buffering agent at a pH of about 5 to about 8.2 and is... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100099150 - Polymerase stabilization by ionic detergents: The invention relates to a composition comprising (i) an enzyme with nucleic acid polymerase activity, (ii) an inert protein and, (ii) a zwitterionic detergent. The invention also relates to a composition comprising (i) an enzyme with nucleic acid polymerase activity, (ii) an inert protein and, (ii) a zwitterionic detergent. The... Agent: Ballard Spahr LLP

20100099151 - Vertical submersible photobioreactor for obtaining biofuels: The invention relates to a vertical submersible photobioreactor for obtaining biofuels, consisting of: vertical towers (1) for performing photosynthesis, which can operate continuously using natural light inlets (12) and lamps (13) for producing artificial light, and a float system (17, 18) which can be used to submerge the towers (1)... Agent: Ladas & Parry LLP

20100099152 - Method for producing l-amino acid: L-amino acids such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, and L-cysteine are produced by culturing in a medium a bacterium having an L-amino acid-producing ability and wherein the bacterium has been modified so that the phosphotransacetylase activity is enhanced.... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100099153 - Method for producing l-amino acids using bacteria belonging to the genus escherichia: A method for producing lower alkyl ester of α-L-aspartyl-L-phenylalanine by cultivating a recombinant Escherichia coli bacterium that has the ability to produce and accumulate an aromatic L-amino acid according in a culture medium to produce and accumulate L-phenylalanine in the medium and synthesizing lower alkyl ester of α-L-aspartyl-L-phenylalanine from the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100099154 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross P.C.

20100099155 - Recovery of volatile products from fermentation broth: Provided are apparatuses and processes for the removal and purification of fermentation prepared one or more volatile organic compounds. The apparatuses comprise a fermentor unit, a vacuum side stripper unit (10), and, optionally, one or more of a pressure-swing adsorption unit, a dual-function column, a dividing wall distillation column unit,... Agent: The Dow Chemical Company

20100099156 - Process for the preparation of ethanol from starch: The present invention provides a process for the preparation of ethanol from starch. Specifically, the present invention provides a process for the preparation of ethanol from starch such as tapioca, potato, sweet sorghum, rice by liquification and saacharification of starch and subsequent fermentation of mono saccherides to ethanol in presence... Agent: Ladas & Parry LLP

20100099157 - Process for the biological generation of methane,: A process is specified for the biological generation of methane (CH4), which process is firstly environmentally friendly and inexpensive, and secondly avoids the use of fossil deposits. The process is divided into two steps, wherein first hydrogen and oxygen (O2) are generated from carbon dioxide (CO2) and water (H2O) by... Agent: Alston & Bird LLP

20100099158 - Bioenergy production apparatus and method: A bioenergy production apparatus (10), including an initial digester (12) for at least partial digestion of digestible material placed therein; a collector (14) formed at or near a base of the initial digester (12), for collecting a leachate product of the digestion of the digestible material; a secondary digester (16)... Agent: Wood, Herron & Evans, LLP

20100099159 - Caged nucleotides and oligonucleotides and their application: There is disclosed nucleotides and nucleotide analogs having a protecting or “caging” group. There is further disclosed oligonucleotides and oligonucleotides analogs formed having a protecting or “caging” group. There is further disclosed a method for decaging the nucleotides and nucleotide analogs having a protecting or “caging” group and oligonucleotides and... Agent: Syntrix Biosystems, Inc.

20100099160 - Dual-functional nonfouling surfaces and materials: Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20100099161 - Alpha-amylase mutants with altered properties: The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered stability, in particular at high temperatures and/or at low pH relative, and/or low Ca2+ to the parent alpha-amylase.... Agent: Novozymes North America, Inc.

20100099162 - Nuclear localization signal of lentiviral integrase and method of use thereof: The present invention provides novel peptides, nucleic acids, vectors, compounds, compositions and methods for regulating nuclear import The present invention also relates to a lentiviral NLS, and methods of use thereof for inhibiting HIV pathogenesis and disease progression, and for gene delivery methods... Agent: Medlen & Carroll, LLP

20100099163 - Separation matrix for viral purification: The present invention relates to a method of preparing a separation matrix comprising at least one insoluble carrier to which sulphate ligands have been attached via extenders, which method comprises coupling, in a first step, of the sulphate ligands to the extenders and, in a subsequent step, attaching the extenders... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100099164 - Method for controlling the growth of cell culture: In a method for controlling the growth of microbes grown in a medium to high cell-densities by the fed-batch technology, a two-phase system, having a liquid phase (cultivation medium) and a solid or gel phase, the solid or gel phase provides a source of substrate-delivering polymer which is turned by... Agent: Young & Thompson

20100099166 - Compositions and methods for enhancing plant growth by chemical oxygenation of soils: Chemical combinations known to be used for odor control are provisioned for enhancing growth of a plant. The chemical combinations preferably include a stable, aqueous solution of a surfactant and a chemical source of oxygen. There are numerous ways by which one could learn that such combinations have utility in... Agent: Fish & Associates, PC Robert D. Fish

20100099165 - Method for growing bacteria: A biomass generator useful for continuously growing and withdrawing bacteria to be used in a desired beneficial application, the generator having a bacteria growth chamber; water and nutrient inlet ports; upper and lower outlet ports; a recirculating pump withdrawing and reintroducing fluid to establish a vortex in the growth chamber... Agent: Locke Lord Bissell & Liddell LLP Attn: Michael Ritchie, Docketing

20100099167 - Alanine 2, 3-aminomutase: Alanine 2,3-aminomutase sequences are disclosed, as are cells having alanine 2,3-aminomutase activity and methods of selecting for such cells. Methods for producing beta-alanine, pantothenate, 3-hydroxypropionic acid, as well as other organic compounds, are disclosed.... Agent: Klarquist Sparkman, LLP

20100099168 - Artificial antibody polypeptides: A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding said monobody, and a variegated nucleic acid library encoding said monobody, are provided by the invention. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform said methods. Further provided is a method of... Agent: Viksnins Harris & Padys Pllp

20100099169 - Genetic selection system for improving recombinant protein expression: A method for selecting host cells with an improved ability to recombinantly overexpress a target protein; the host cells thus generated and their use. The invention also provides a curing method to remove plasmids from host cell lines.... Agent: Bozicevic, Field & Francis LLP

20100099170 - Methods of controlling open algal bioreactors: A method controls growth in an open algae cultivation system. The cultivation system includes a high-yield species and at least one invasive native species. The method includes adjusting at least one parameter of the system to a first value such that a high-growth condition for the high-yield species is produced... Agent: Brown & Michaels, PC 400 M & T Bank Building

20100099171 - Vitrification apparatus for microdrop vitrification of cells and a method of microdrop vitrification of cells using the apparatus: An apparatus for microdrop vitrification has a tank and two wings. The tank has a bottom, two side edges, two top edges, two sidewalls, a lowest bottom, a drain and a spout. The drain is defined in one of the sidewalls at the bottom of the tank. The spout is... Agent: Hershkovitz & Associates, LLC

20100099172 - Integrated bio-reactor monitor and control system: Systems and methods for automatically controlling conditions of a process are disclosed. In one example, a controller is programmed with a sequence of steps and parameters required to carry out a bioreactor process. A sensor system interacts with the bioreactor to receive information related to a condition of the bioreactor... Agent: Knobbe Martens Olson & Bear LLP

20100099174 - Method and apparatus for providing power management in data communication systems: A blood glucose meter having a compact housing, a display unit disposed on the housing, the display unit including a display light source to illuminate the display unit, an input unit disposed on the housing, the input unit configured to provide input functions for the blood glucose meter, and a... Agent: Abbott Diabetes Care Inc. Bozicevic, Field & Francis LLP

20100099173 - Quantitative liquid injection device of plasma sterilizer: Disclosed herein is a device for quantitatively supplying a liquid in a plasma sterilization system. The device includes a quantitative cylinder, a quantitative piston and a quantitative basket. The quantitative cylinder includes a quantitative inlet pipe, which is configured such that the outlet of a liquid container is inserted thereinto,... Agent: Kang Intellectual Property Law, LLC

20100099176 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: Searete LLC Clarence T. Tegreene

20100099175 - Two-stage nucleic acid amplification using an amplification oligomer: This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a second nucleic acid amplification or assay. Two or more amplification oligomers can... Agent: Quine Intellectual Property Law Group, P.C.

20100099179 - Chromatography quantitative measuring apparatus: In a chromatography quantitative measuring apparatus according to the present invention, a beam applied from a light source to a chromatography test strip is formed into an elliptical shape by an optical means such as a cylindrical lens, a variation in absorbance that accompanies elution of a marker regent is... Agent: Wenderoth, Lind & Ponack L.L.P.

20100099178 - Contaminant detection apparatus: A contaminant detection apparatus comprising a powered portable detection device for detecting the presence of at least one pathogen in a sample; a test applicator kit comprising a sample applicator and a cartridge configured to receive and retain the sample applicator; the sample applicator including a swab having a first... Agent: Vidas, Arrett & Steinkraus, P.A.

20100099177 - In-situ optical monitoring subsystem compatible with cell incubators: An optical monitoring subsystem includes: a differential interference contrast (DIC) optical-path apparatus having a CCD camera and enclosed in a gas-tight housing stored in an incubator and a three-dimension electric driving device operatively moving along three axes of three-dimension coordinates for conveniently observing, monitoring or photographing cells in a cell... Agent: Lung-jieh Yang

20100099180 - Non-woven cover for containing and abating odiferous organic emanations: An odiferous organic compounds cover having an inner surface and an outer surface. The cover contains a thermoplastic non-woven layer having a first side and a second side and comprising thermoplastic fibers. The first side of the non-woven layer forms the inner side of the cover, has a contact angle... Agent: Legal Department (m-495)

20100099181 - Streaking applicator cartridge and a system for connecting same to a streaking apparatus: A cartridge for holding and dispensing streaking applicators for an automated streaking apparatus having a cartridge holder, the cartridge including: a case with a dispensing end, a longitudinal axis and an elongate slot generally parallel to the longitudinal axis, the dispensing end including an applicator dispensing position where one applicator... Agent: Crompton, Seager & Tufte, LLC

20100099182 - System for monitoring the location of transgenes: A novel strategy for monitoring the location of a transgene in a mammal is disclosed. A sodium iodide symporter is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease. Expression of... Agent: Fish & Richardson P.C.

20100099183 - Vectors and methods for enhanced cell longevity and protein expression: It is the object of the current invention to provide methods and compositions relating to the expression of vankyrin proteins in cell lines to increase their viability, longevity and capacity for protein production. The inventors have discovered that the expression of P-ank-1 and I2-ank-3 proteins in cell culture has increased... Agent: Mcdermott Will & Emery LLP

20100099184 - Polynucleotides encoding class ii cytokine receptor-7: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation... Agent: Zymogenetics, Inc. Intellectual Property Department

20100099185 - Method of making biologically active alpha-beta peptides: Described is a method of fabricating biologically active, unnatural polypeptides. The method includes the steps of selecting a biologically active polypeptide or biologically active fragment thereof having an amino acid sequence comprising α-amino acid residues, and fabricating a synthetic polypeptide that has an amino acid sequence that corresponds to the... Agent: Intellectual Property Dept./dewitt Ross & Stevens Wisconsin Alumni Research Foundation

20100099186 - Methods, kits, and compositions for stem cell self-renewal: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.... Agent: Kevin C. Hooper, Bryan Cave LLP

20100099187 - Method for producing a vaccine for the treatment of cancer: The present invention discloses a method for producing a haptenized vaccine from a tissue biopsy. The method includes obtaining a tissue biopsy, isolating the cells, irradiating the cells, haptenizing the cells, and cryopreserving the cells. The present invention also discloses a method for treating cancer using the vaccines produced by... Agent: Morgan, Lewis & Bockius LLP

20100099188 - Dual inhibitors of hiv-1 gp-120 interactions: Compounds, which inhibit the binding of gp120 to CD4 as well as 17b and methods for their use in inhibiting the HIV fusion process, are provided.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100099189 - Methods for rejuvenating cells in vitro and in vivo: The present invention provides methods for rejuvenating cells, tissues and the whole body. Also provided are rejuvenating buffers and agents as well as kits for rejuvenating cells. Also provided are methods for dedifferentiating somatic cells and differentiating the cells into other cell types.... Agent: The Luther Law Firm, PLC

20100099190 - Cultured cell construction containing spheroids of mesenchymal stem cells and utilization thereof: Facing no ethical obstacle and easily to be isolated, multipotent concretely mesenchymal stem cells (MSCs) are one of the most powerful tools in reconstructive medicine. Here the inventors introduced 3D multicelluar spheroids culture construction based on photolithography and micropatterning techniques to improve multipotent differentiation efficiency of MSCs to adult cells.... Agent: Sughrue Mion, PLLC

20100099191 - Rna interference tags: The invention relates to a composition for inhibiting the expression of a target gene in a eukaryotic cell by RNA interference, the composition comprising a genetic construct and the target gene being introduced into the eukaryotic cell by means of said construct, and the construct having a first target gene... Agent: Rankin, Hill & Clark LLP

  
04/15/2010 > patent applications in patent subcategories. category listing, related patent applications

20100092938 - Novel and practical serological assay for the clinical diagnosis of leishmaniasis: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite... Agent: Office Of The Staff Judge Advocate (sks) U.s. Army Med. Research & Materiel Command

20100092939 - System and method for perfusing biological organs: A system for perfusing a biological organ for use as an experimental model includes a housing having sides that define a cavity for containing a biological organ model within a solution. The housing includes a plurality of apertures defined therethrough configured to mechanically interface with a filter, one or more... Agent: Tyco Healthcare Group Lp Attn:IPLegal

20100092941 - 32142,21481,25964,21686, novel dehydrogenase molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which... Agent: Millennium Pharmaceuticals, Inc.

20100092944 - Detection of influenza virus: The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or... Agent: Townsend And Townsend And Crew, LLP

20100092942 - Method and apparatus for detection of biological organisms using raman scattering: A system for the detection of compounds, including a target biological organism or component from a sample, using one or more reactant that will bind to the biological organism or compound forming a Raman active product, concentrating the Raman active product, and detecting the Raman active product using Raman light... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100092940 - Method and device for detecting feline immunodeficiency virus: A method and device for determining a feline immunodeficiency virus infection or vaccination in an animal. The method includes contacting a biological sample from a felid with various FIV polypeptides and determining the binding of antibodies in the sample to the polypeptides. The determination of whether an animal is infected... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100092943 - Screening method with the use of tbk1 knockout mouse: The present invention provides a method for screening inductive promoting substances of anti-viral proteins such as IFN-β against LPS stimulation or viral infection by using TBK1 knockout mice, or the tissues or cells derived therefrom. The present invention also provides a method for screening substances promoting responses against LPS stimulation... Agent: Frommer Lawrence & Haug

20100092945 - Test strip for a lateral flow assay for a sample containing whole cells: A test strip for conducting a lateral flow assay for detection of an analyte in a sample that contains cells and fluid is provided, as well as methods for making and using the test strip. This test strip is commercially usable, for example, in a diagnostic device at a point... Agent: Global Patent Group - Rla

20100092956 - Analytical processing and detection device: An analytical processing and detection device is described which comprises a rack capable of holding at least one reaction receptacle, at least one magnetic unit for exerting a magnetic field on at least one reaction receptacle comprising magnetic particles in a fluid, wherein said at least one magnetic unit is... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100092972 - Assay for gene expression: An assay for gene expression comprising treating RNA with an agent such as bisulphate that substantially removes secondary structure of the RNA; and measuring the presence or amount of treated RNA so as to obtain an indication of gene expression. The invention also includes use of oligonucleotide, PNA, LNA or... Agent: Knobbe Martens Olson & Bear LLP

20100092948 - Biological bar code: The invention provides compositions and methods useful for identifying, verifying or authenticating any type of sample, whether the sample, is biological or non-biological.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100092967 - Bioluminescent assays utilising secreted luciferases: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100092978 - Cadherin-17 as diagnostic marker and therapeutic target for liver cancer: Compositions and methods for diagnosing, treating and/or preventing cancers characterized by CDH17 overexpression based on the detection of CDH17 or the use of CDH17 as a target for therapeutic intervention or prophylactic intervention are provided. Methods for diagnosing and/or monitoring liver cancers using the expressing of CDH17 involve detecting and/or... Agent: Pabst Patent Group LLP

20100092969 - Cell isolation method, cell testing method and reagent kit therefor: The present invention provides a cell isolation method, a cell screening process, and a reagent kit therefor. In the present invention, the recognition substance is a polynucleotide specifically bound to a particular antigen that exists on the surface of a specific cell. This recognition substance is made to bind with... Agent: Sughrue Mion, PLLC

20100092957 - Compositions and methods for nucleotide sequencing: The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or... Agent: Mcdermott, Will & Emery

20100092971 - Compound having structure derived from mononucleoside or mononucleotide, nucleic acid, labeling substance, and method and kit for detection of nucleic acid: In the above formulae, B is an atomic group having a nucleobase skeleton, E is an atomic group having a deoxyribose skeleton, a ribose skeleton, or a structure derived from either one of them, or an atomic group having a peptide structure or a peptoid structure, and Z11 and Z12... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100092970 - Determining the phase of duplicated cyp2d6 alleles: This document relates to methods and materials involved in detecting duplicated CYP2D6 alleles (e.g., CYP2D6/CYP2D7−CYP2D6 arrangements) in mammals (e.g., humans).... Agent: Fish & Richardson P.C.

20100092952 - Four-color dna sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.... Agent: Cooper & Dunham, LLP

20100092950 - Fuidi herd management schema: The invention is a herd management schema based upon the inventor's analysis of the natural history of bovine infection due to Mycobacterium avium subspecies paratuberculosis (Map) and related genomic variants and upon the ability of two distinct Map ELISA tests to sequentially or in parallel determine prior and current Map... Agent: Gilles R. G. Monif

20100092955 - Gel microdrop composition and method of using the same: A gel microdrop composition is provided. In certain embodiments, the gel microdrop composition contains a polymer matrix, an effector particle that releases an effector molecule into the polymer matrix, a first reporter particle that emits a first optically detectable signal and a second reporter particle that emits a second optically... Agent: Bozicevic, Field & Francis LLP

20100092989 - Genes useful for diagnosing and monitoring inflammation related disorders: Described herein is a system for monitoring gene expression for diagnosing and monitoring inflammation disorders, and for monitoring gene expression in inflammation disorders in response to a particular drug treatment regimen. This system for detecting nucleic acid expression in a body fluid uses an isolated polynucleotide to detect expression of... Agent: Morrison & Foerster LLP

20100092964 - Genetic diagnosis using multiple sequence variant analysis: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention... Agent: Mcandrews Held & Malloy, Ltd

20100092946 - Genetic methods for speciating campylobacter: The phylogeny of twelve Campylobacter species was determined based on partial (1020-bp) gyrB gene sequences. Methods have been described for detection and speciation of Campylobacter, including 16S rRNA sequence analysis. However, gyrB provides a better resolution than the 16S rDNA gene for Campylobacter species with interspecies sequence similarities ranging from... Agent: Usda, Ars, Ott

20100092965 - Genetic variations associated with tumors: Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.... Agent: Genentech, Inc.

20100092960 - Helicase-assisted sequencing with molecular beacons: Provided are compositions that include an at least partially single-stranded nucleic acid, at least one first molecular beacon, and an enzyme comprising a helicase activity, which enzyme is capable of removing the first molecular beacon from the single-stranded nucleic acid wherein the first molecular beacon is hybridized to a first... Agent: Quine Intellectual Property Law Group, P.C.

20100092947 - Impdh2 snp associated with acute rejection: The present invention concerns a method for the prediction of acute renal transplant rejection by detecting a polymorphism in intron 7 of the IMPDH2 gene, optionally in combination with polymorphisms of the MDR1 and IL 10 genes which were found to be associated with this disease.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100092977 - Irf-5 haplotypes in systemic lupus erythematosus: Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.... Agent: Fish & Richardson P.C.

20100092963 - Kits and methods for selective amplification and detection of nucleic acid target: The application relates generally to kits and methods useful for the selective capture, amplification and/or detection of one or more nucleic acid targets, as well as compositions comprising said amplification reaction mixtures. More specifically, the application relates to a signal primer that comprises (i) a target-specific sequence which hybridizes specifically... Agent: Jones Day

20100092968 - Method and means for enrichment, removal and detection of gram-positive bacteria: The present invention relates to polypeptides comprising a enzymatically non-active cell wall binding domain of an endolysin or another cell wall lysing enzyme, and a sequence according to SEQ ID NO: 1 or derivatives thereof, wherein the polypeptide besides the cell wall binding domain comprises no further domains of an... Agent: Fulbright & Jaworski L.L.P.

20100092966 - Method for detecting pyrophosphate by means of bioluminescence detection: e

20100092954 - Method for determining the genetic basis for physiological changes in organisms: The present invention provides a method for discovering the basis of changes in the observable properties of organisms by subjecting an organism to selection. Individual organisms with observable differences will thus become more prevalent in a population during selection. The basis for the differences are then determined by identifying genetic... Agent: Dla Piper LLP (us)

20100092951 - Method for methylation analysis of nucleic acid: The present invention relates to a method for methylation analysis. It comprises the providing of a double stranded nucleic acid; its conversion, whereby unmethylated bases become distinguishable in their base-pairing behavior from methylated bases, and the analysis of both of the converted nucleic acid strands.... Agent: Kriegsman & Kriegsman

20100092983 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP

20100092984 - Method for the detection of gene transcripts in blood and uses thereof: The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of... Agent: Edwards Angell Palmer & Dodge LLP

20100092962 - Method of detecting colorectal cancer: A method for predicting the presence of colorectal cancer based on the concentration of DNA in a sample of exfoliated cells collected directly from the surface of the rectal mucosa of a subject. The method consists of quantifying the concentration of DNA in a lysate containing exfoliated cells and correlating... Agent: Fox Rothschild, LLP Pittsburgh

20100092961 - Methods and compositions for detection of cowden syndrome (cs) and cs-like syndrome: In one aspect, the invention is directed to a method of detecting Cowden syndrome (CS) or CS-like syndrome in an individual comprising detecting the presence of a mutated succinate dehydrogenase B (SDHB), mutated succinate dehydrogenase D (SDHD) or combination thereof in the individual, wherein detection of a mutated SDHB, SDHD... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100092979 - Methods and compositions for isolating nucleic acid: The present invention relates to compositions and methods for isolating and purifying nucleic acid. In particular, the present invention relates to methods of isolating nucleic acid from cells for use in further analysis.... Agent: Casimir Jones, S.c.

20100092988 - Methods and compounds for chemical ligation: Compositions and methods for chemical ligation are provided. Methods for nucleic acid sequencing, nucleic acid assembly and nucleic acid synthesis are also provided.... Agent: Banner & Witcoff, Ltd.

20100092973 - Methods and devices for digital pcr: The invention provides methods of conducting a nucleic acid reaction, including methods for performing digital PCR using a “droplet-in-oil” technology. In the methods, the starting sampled is segmented at least partially into a set of sample droplets each containing on average about one or fewer copies of a target nucleic... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100092953 - Methods and nucleic acids for analyses for cellular proliferative disorders: The invention provides methods, nucleic acids and kits for detecting a cell proliferative disorder. The invention discloses genomic sequences of RASSF-2 the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.... Agent: Davis Wright Tremaine, LLP/seattle

20100092986 - Methods and tools for detecting the presence of colorectal adenocarcinoma cells: The present invention discloses methods and tools for reliably detecting the presence of adenocarcinoma cells in a patient, at the genetic level. The present invention fine-maps the regions of chromosomal aberrations linked to progression of adenomas into adenocarcinoma cells and provides methods and tools for detection based thereon.... Agent: Philips Intellectual Property & Standards

20100092949 - Methods for detecting staphylococcus aureus: Methods and oligonucleotides for detecting staphylococci, such as Staphylococcus aureus., in a sample.... Agent: 3m Innovative Properties Company

20100092958 - Methods for determining collateral artery development in coronary artery disease: The present invention relates to a method for determining collateral artery development in a human subject with coronary artery disease based upon the levels of expression of markers associated with collateral artery development in coronary artery disease.... Agent: Licata & Tyrrell P.C.

20100092974 - Methods for screening for modulators of ccrl2: The invention provides methods and compositions for identifying a modulator of CCRL2 and chemerin. The present invention also provides methods and compositions for treating an inflammatory disease by administering a compound that modulates the interaction of CCRL2 with chemerin.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20100092981 - Methods of detecting hypermethylation: Aspects of the invention relate to methods of detecting cancer, such as colon cancer. In aspects of the invention, methods for detecting the presence of hypermethylated genomic DNA in a biological sample are disclosed. Methods of the invention relate to detecting small amounts of hypermethylated nucleic acids in a biological... Agent: Choate, Hall & Stewart LLP

20100092987 - Microfluidic analysis system: A microfluidic analysis system (1) performs polymerase chain reaction (PCR) analysis on a bio sample. In a centrifuge (6) the sample is separated into DNA and RNA constituents. The vortex is created by opposing flow of a silicon oil primary carrier fluid effecting circulation by viscous drag. The bio sample... Agent: Brown Rudnick LLP

20100092990 - Nucleic acids encoding sodium channel scn1a alpha subunit proteins and mutations associated with epilepsy: The present invention relates to epilepsy. More particularly, the present invention relates to idiopathic generalized epilepsy (IGE) and to the identification of three genes mapping to chromosome 2, which show mutations in patients with epilepsy. The invention further relates to nucleic acid sequences, and protein sequences of these loci (SCNA)... Agent: Goudreau Gage Dubuc

20100092991 - Rapid detection processes and related compositions: An improved detection method is described for an antigen such as a chemical compound, a peptide, or a nucleic acid. The detection time for an antigen can be dramatically reduced relative to conventional technologies. The technology can particularly be used, for example, to modify and reduce the detection time significantly... Agent: Eckert Seamans Cherin & Mellott

20100092980 - Reagent for elimination of red blood cells and hemoglobin in a sample: The invention relates to a method for isolating nucleic acid from a blood sample, including individual blood samples or pooled samples, such as in blood banks. Furthermore, this invention relates to a reagent kit suitable for carrying out the method of the invention.... Agent: Dla Piper LLP (us)

20100092982 - Regulation of gene expression by protein methylation: The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins.... Agent: Foley & Lardner LLP

20100092959 - Single nucleotide polymorphisms as genetic markers for childhood leukemia: The present invention is directed to a panel of single nucleotide polymorphisms (SNPs) in specific genes that serve as biomarkers for sex-specific childhood leukemia risk. There is provided herein methods and reagents for assessing the specific SNPs in those genes. The method useful in applying these SNPs in predicting an... Agent: Medical Diagnostic Laboratories, LLC

20100092985 - Solid support with enhanced density of signal material, kit containing the same and method of detecting target material using the same: A solid support on which a labeled nucleic acid including a high density of signal materials, a kit containing the same, and a method of detecting a target material are provided.... Agent: Sughrue Mion, PLLC

20100092976 - Thermostable duplex-specific nuclease: The present invention provides a thermostable duplex-specific nuclease (DSN) and a method for digesting a nucleic acid using said DSN, namely, a protein having a Brachyura-derived duplex-specific nuclease activity, a gene encoding for said protein, a recombinant vector comprising said gene and a transformed cell or transduced cell comprising said... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100092975 - Use of novel cytokine receptors as biomarkers and therapeutic targets in human cancer: Nucleic acids encoding erythropoietin isoforms are described herein, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.... Agent: Myers Bigel Sibley & Sajovec

20100092995 - Fluorescent ruthenium compounds for detecting calcium binding proteins: A fluorescent compound exhibiting a high affinity to calcium-binding proteins (CaBP) is provided. The compound, containing ruthenium, enables to detect, identify, and isolate CaBPs involved in cellular signaling and regulation. The compound is employed for diagnosing a disorder associated with CaBPs defects.... Agent: Kevin D. Mccarthy Roach Brown Mccarthy & Gruber, P.C.

20100092994 - High specificity monoclonal antibody against a protein or a polypeptide having oxidative modification: The present invention provides an antibody, which reacts with a FGA or FGA partial peptide in which a part of prolines in the molecule thereof are hydroxylated, and which does not react with an unmodified FGA or FGA partial peptide.... Agent: Birch Stewart Kolasch & Birch

20100092992 - Lysine acetylation sites: The invention discloses 322 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100092997 - Method of enhancing of binding activity of antibody composition to fcgamma receptor iiia: A method for enhancing a binding activity of an antibody composition to Fcγ receptor IIIa, which comprises modifying a complex N-glycoside-linked sugar chain which is bound to the Fc region of an antibody molecule; a method for enhancing an antibody-dependent cell-mediated cytotoxic activity of an antibody composition; a process for... Agent: Sughrue-265550

20100092998 - Methods and compositions relating to e3 ring-e2 fusion proteins: Compositions are provided according to embodiments of the present invention which include an isolated fusion protein including an E3 protein RING motif bonded to an UCE E2 protein. In preferred embodiments, the C-terminus of the E3 protein RING motif is bonded to the N-terminus of the UCE E2 protein by... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20100092996 - Microelectronic sensor device for detecting label particles: The invention relates to a microelectronic sensor device for the detection of target components that comprise label particles, for example magnetic particles (1). The sensor device comprises a carrier (11) with a binding surface (12) at which target components can collect and optionally bind to specific capture elements. An input... Agent: Philips Intellectual Property & Standards

20100092993 - Quantitative analyzing method: This invention discloses an analyzing method for detecting a specific analyte in a fluid sample. The method comprises the following steps. First, a substrate is provided. The substrate has a channel provided concavely on an upper surface thereof. The channel comprises a first area, a second area and a third... Agent: Sinorica, LLC

20100092999 - Xanthurenic acid derivative pharmaceutical compositions and methods related thereto: i

20100093000 - Tyrosine phosphorylation sites: The invention discloses novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100093001 - Means and methods for the production of amyloid oligomers: The present invention relates to the field of amyloid disorders, more particularly to the field of diseases where protein misfolding leads to the generation of insoluble amyloid fibers in tissues and organs. The invention provides methods for the production of soluble, toxic amyloid oligomers. The invention further provides assays using... Agent: Traskbritt, P.C.

20100093002 - Diagnosis and treatment of malignant neoplasms: The invention features a method of inhibiting tumor growth and/or tumor invasiveness in a mammal by administering to a mammal a compound (e.g., an antagonistic antibody) which inhibits expression or enzymatic activity of human aspartyl (asparaginyl) beta-hydroxylase (HAAH). The invention also features a method for diagnosing the growth of a... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100093003 - Methods to impair hematologic cancer progenitor cells and compounds related thereto: Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3Rα or CD123) is strongly expressed on progenitor hematologic cancer cells,... Agent: Jones Day

20100093004 - Autophagy and phospholipidosis pathway assays: Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues... Agent: Enzo Biochem, Inc.

20100093006 - High affinity anti-n1,n12-diacetylspermine monoclonal antibody: The present invention provides an anti-diacetylspermine specific monoclonal antibody which satisfies a specific measuring condition in an immunoreaction system between a solid-phased diacetylspermine and the anti-diacetylspermine specific monoclonal antibody, wherein the immunoreaction system comprises a sample diacetylspermine or sample N1-acetylspermidine to inhibit the immunoreaction; and the specific measuring condition is... Agent: Dickstein Shapiro LLP

20100093005 - Identifying duct cancers: This document relates to methods and materials involved in identifying mammals that are likely to have duct cancer. For example, this document provides methods and materials related to using the presence of a variant form of the secretin receptor in a mammal's blood to identify the mammal (e.g., human) as... Agent: Fish & Richardson P.C.

20100093007 - Method of diagnosis of tuberculosis related immune restoration syndrome (irs): The present invention relates to a method and kit of diagnosis of Immune Restoration Syndrome associated with tuberculosis (TB-IRS) in patients infected with tuberculosis (TB) as well as in HIV co-infected patients comprising detecting an acute increase in Th1 response following exposure to mycobacterial extract, referred as tuberculin or PPD... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20100093008 - Phospho-specific antibodies to flt3 (tyr969) and uses thereof: The invention discloses a newly discovered Flt3 phosphorylation site, tyrosine 969 (Tyr969) in the intracellular domain, and provides reagents, including polyclonal and monoclonal antibodies, that selectively bind to Flt3 when phosphorylated at this site. Also provided are assays utilizing this reagent, including methods for determining the phosphorylation of Flt3 in... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100093009 - Alternative crystal form of monoacylglycerol lipase (mgll): A number of soluble engineered forms of MGLL that are suitable for high-throughput screening and protein crystallization, as well as a crystallized forms of monoacylglycerol lipase protein (MGLL) and descriptions of the X-ray diffraction patterns are disclosed. The engineered constructs of MGLL permit the expression and purification of protein suitable... Agent: Philip S. Johnson Johnson & Johnson

20100093010 - Inhibitor for the formation of gamma-secretase complex: It is intended to provide an inhibitor for the formation of a γ-secretase complex which comprises a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator as the active ingredient; and use of a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator for producing the same. It is also intended to... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100093011 - Amine-containing compound analysis methods: The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or more amine-containing compounds with different isobaric tags from a set of... Agent: Life Technologies Corporation C/o Intellevate

20100093013 - Corrugated and nanoporous microstructures and nanostructures, and methods for synthesizing the same: A method of synthesizing corrugated and nanoporous microspheres including the steps of synthesizing substantially smooth spherical microspheres, and controlled wet-etching of the substantially smooth spherical microspheres with a basic solution having a pH above 10.00 is provided. The microspheres can include, for example, silica microspheres or titania microspheres of various... Agent: Bond Schoeneck & King, PLLC

20100093012 - Diagnosis and risk stratification of cardiac insufficiency using neurophysin: The invention relates to a method for the diagnosis and/or risk stratification of cardiac insufficiency, according to which the marker neurophysin or a fragment or partial peptide thereof is determined on patients to be examined. The invention also relates to advantageous marker combinations containing neurophysin, and to a diagnostic device... Agent: Connolly Bove Lodge & Hutz, LLP

20100093018 - Cells expressing chimeric proteins and assays using such cells: Cells expressing chimeric hepatitis C virus NS4A protein are disclosed, as are vectors and methods for preparing such cells and methods of using the cells and the chimeric proteins therein in screening assays for detecting compounds that alter the associative characteristics of NS4A proteins. Disclosed screening assays are suitable for... Agent: Cantor Colburn, LLP

20100093017 - Metabolically competent cell lines: The present invention provides cell lines that have been transfected with adenovirus expression vectors so that they express at least one metabolically competent or functional cytochrome P450 enzyme. The invention also includes methods of their use, especially in toxicology screens.... Agent: Myers Bigel Sibley & Sajovec

20100093016 - Microfluidic apparatus and method for preparing cytological specimens: An apparatus for processing a specimen from a fluid sample includes a first set of one or more microfluidic channels configured to deliver the sample fluid to a filter disposed on an inflatable bladder configured to transfer the specimen from the filter to a slide. The apparatus is configured to... Agent: VistaIPLaw Group LLP

20100093014 - Screening for bone anabolic factors: A method for screening for modulators of the secretion by an osteoclast of a wnt or a wnt signal enhancer comprises exposing osteoclasts in culture to a compound to be screened, exposing a wnt sensitive detection system to conditioned medium from said osteoclast culture, and determining whether a wnt signal... Agent: Edwards Angell Palmer & Dodge LLP

20100093015 - Spectroscopic systems and methods for classifying and pharmaceutically treating cells: A system and method to distinguish normal cells from cells having undergone a biochemical change. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference spectral data sets for normal cells and a second plurality of reference spectral data sets for cells having... Agent: Chemimage Corporation

20100093019 - Sample handling device: A device for use in handling a sample, the device including a number of deformable cavities provided on a surface of a substrate, at least one of the cavities being a sample cavity for receiving a sample and a number of fluid channels connecting the cavities such that in use,... Agent: Morris Manning Martin LLP

20100093020 - Solvent tolerant microorganisms and methods of isolation: Enterococcus bacteria having enhanced tolerance to butanols have been isolated. The bacteria are useful for the fermentive production of butanol. New methods for the isolation of butanol tolerant Enterococcus are also provided.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100093021 - Hardening of ordered films of silica colloids: Sintering self-assemblies of calcined colloidal silica particles results in sintered colloidal crystals that are free of cracks that can be resolved using optical microscopy. The sintered colloidal crystals have significantly improved strength and durability, and withstand aggressive handling. Surface rehydroxylation of the sintered colloidal crystals enables subsequent chemical modification.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100093022 - Methods and apparatus for providing and processing sliced thin tissue: Methods and apparatus for providing and processing serial tissue sections. In one example, an “automatic tape collecting lathe ultramicrotome” (ATLUM) slices a block of tissue sample having various geometries into a continuous ribbon of thin tissue, or multiple thin tissue sections, and disposes the sliced thin tissue on an appropriate... Agent: Wolf Greenfield & Sacks, P.C.

20100093023 - Process for preserving three dimensional orientation to allow registering histopathological diagnoses of tissue to images of that tissue: A process for maintaining 3 dimensional orientation between a tissue specimen and images of the area of investigation, to register histopathologic diagnoses of multiple locations within the specimen with corresponding locations on the surface of said area of investigation, by marking at least two fiduciary lines on the area of... Agent: Cades Schutte A Limited Liability Law Partnership

20100093024 - Cell-free synthesis of proteins containing unnatural amino acids: Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of polypeptides containing unnatural amino acids at one or more specified residues of the polypeptide.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20100093025 - Method for producing a yeast extract: The present invention relates to a method for producing a yeast extract using an exogenous protease.... Agent: Novozymes North America, Inc.

20100093034 - Alkaline bacillus amylase: This invention relates to an amylase derived from Bacillus horikoshii. The amylase has a preference for soluble substrates, shows substantial exo-amylase activity and has a pH optimum of about 9.8.... Agent: Novozymes North America, Inc.

20100093031 - Dna encoding xylitol dehydrogenase: The present invention relates to DNA encoding novel xylitol dehydrogenase and a method for using the same. Specifically, the present invention comprises providing the nucleic acid sequence of a xylitol dehydrogenase gene from Candida shehatae and introducing this gene into a host organism, thereby producing a microorganism having the ability... Agent: Foley And Lardner LLP Suite 500

20100093027 - Enzyme: The present invention provides for a substantially pure human or rabbit 3-phosphoinositide-dependent protein kinase.... Agent: Knobbe Martens Olson & Bear LLP

20100093033 - Inducible mutagenesis of target genes: The present invention relates generally to mutagenesis of target genes that takes advantage of the natural mutagenic capabilities of B cells, and enhances those capabilities by bringing the process of diversification under control. The invention provides a method for rapidly and inducibly generating point mutations and other types of diversification... Agent: Karen S. Canady Canady & Lortz LLP

20100093029 - Modified luciola cruciata luciferase gene and protein: A codon optimized and stabilized luciferase gene based upon the sequence of the natural luciferase gene isolated from Luciola cruciata (Japanese firefly) and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in mammalian cells, are disclosed.... Agent: Dr. John Naleway Marker Gene Technologies

20100093032 - Modified microorganism: To provide a microorganism with enhanced secretory production of a protein or polypeptide and a method of producing the protein or polypeptide using the microorganism. A modified microorganism that has been genetically modified to delete 60 to 80 carboxyl-terminal amino acids of SecA.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100093028 - Modified variant bowman birk protease inhibitors: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing... Agent: Danisco US Inc. Attention: Legal Department

20100093026 - Novel endoribonuclease: A polypeptide having a novel endoribonuclease activity; a nucleic acid encoding the polypeptide; recombinant DNA having the nucleic acid therein; a transformant transformed with the recombinant DNA; a process for producing the polypeptide comprising the steps of cultivating the transformant and collecting the polypeptide from the culture; a process for... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100093030 - Production of secreted proteins by filamentous fungi: The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably... Agent: Nixon & Vanderhye, PC

20100093035 - Novel streptococcus antigens: Streptococcus proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.... Agent: Seed Intellectual Property Law Group PLLC

20100093036 - Novel vectors for production of growth hormone: The present invention provides novel compositions to transfect cells for production of growth hormone (GH). These novel compositions also are used to produce germline transgenic birds that can successfully pass the transgene encoding growth hormone to their offspring. These novel compositions include components of vectors such as a vector backbone,... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20100093037 - Growth of microorganisms in media containing soy components: The present invention provides novel methods of growing of microorganisms in cell culture media comprising soy components (e.g., soy molasses) as a carbon source. The present invention further provides novel cell culture media comprising soy components (e.g., soy molasses) as a carbon source. In certain embodiments, inventive cell culture media... Agent: Choate, Hall & Stewart LLP

20100093039 - Cell culture media for enhanced protein production: Culture media for in vitro cell culture which contain substantially saturated amounts of selected amino acids improve protein production, constrain cell growth and extend cell longevity, methods for the production and use of such media, and systems fox the production of protein utilizing such media and methods.... Agent: Dla Piper LLP (us)

20100093038 - Means and methods for influencing the stability of cells: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies... Agent: Traskbritt, P.C.

20100093040 - Modified beta-glucosidases with improved stability: Provided are modified beta-glucosidase enzymes, derived from the Trichoderma reesei Cel3A beta-glucosidase, that exhibit improved stability at low pH, low pH and high aeration, low pH and high agitation, or low pH and elevated temperature. Also provided are genetic constructs comprising nucleotide sequences encoding for modified beta-glucosidase enzymes, methods for... Agent: Fitzpatrick Cella Harper & Scinto

20100093041 - Method for the prevention of carryover contamination in nucleic acid amplification technologies: An improved method of preventing carryover contamination of an amplification reaction involves treating uracil-containing DNA with uracil-N-DNA glycosylase and heating the DNA in the presence of polyamines, such as spermidine, spermine and the like. Alternatively, after treatment with uracil-N-DNA glycosylase, the reaction is further incubated with an enzyme having AP... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100093042 - Compositions and methods for enhanced bacterial exopolysaccharide production: The present invention provides nucleic acid sequences and variants thereof capable of modulating exopolysaccharide production in Sphingomonas, and provides methods of using such nucleic acid sequences to generate bacteria that hyper-produce exopolysaccharide in slime form.... Agent: Seed Intellectual Property Law Group PLLC

20100093043 - Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids: The gene encoding a 4-hydroxybutyryl-Co A transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, including both bacteria and plants. The new pathways provide means for producing 4HB containing... Agent: Pabst Patent Group LLP

20100093044 - Amino acid producing microorganism and a method for producing an amino acid: A microorganism is provided which has an ability to produce an L-amino acid such as L-lysine, L-tryptophan, L-phenylalanine, L-valine, L-leucine, L-isoleucine and L-serine, and has been modified to increase the activity of pyruvate synthase or pyruvate:NADP+ oxidoreductase. This microorganism is cultured in a medium containing ethanol or an aliphatic acid... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100093045 - L-cysteine producing microorganism and a method for producing l-cysteine: L-cysteine is produced by culturing an Escherichia bacterium having L-cysteine producing ability and containing a gene encoding an O-acetylserine sulphydrylase B or MalY regulatory protein that is modified so that cysteine desulfhydrase activity is reduced or eliminated. The bacterium is cultured in a medium to produce and cause accumulation of... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100093046 - Energy production with hyperthermophilic organisms: The present invention relates to the field of degradation with hyperthermophilic organisms, and in particular to the use of hyperthermophilic degradation to produce heat and energy rich components including hydrogen and ethanol from a biomass. In some embodiments, a biomass is fermented in the presence of hyperthermophilic organisms to produce... Agent: Casimir Jones, S.c.

20100093047 - Microbial processing of cellulosic feedstocks for fuel: A system and method are provided which utilize microbes to convert biomass feedstock into a fuel. In one aspect, a method of producing lipids includes receiving a feedstock including biomass, exposing the feedstock to microbes which are capable of converting the feedstock into lipids, and extracting produced lipids.... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20100093049 - Biological methane production from coal, manure, sludge, wastes, or other carbonaceous feedstocks with simultaneous sequestration of co2: The present invention provides a method for generating methane from a carbonaceous fuel source with simultaneous sequestration of carbon dioxide, the method comprising anaerobically incubating a particulate alkaline earth metal salt in contact with a particulate and/or dissolved carbonaceous feedstock in a neutral or alkaline aqueous culture medium containing a... Agent: Olson & Cepuritis, Ltd.

20100093048 - Process and apparatus for assisting the extraction and processing of biodiesel oil using oil-bearing and other organic feedstock: A process and apparatus for assisting the extraction and processing of biodiesel oil from organic feedstock includes: providing crushed oil-bearing organic feedstock meal from which has been extracted a first amount of biodiesel oil wherein the meal retains a second amount of entrained oil; forming a meal slurry containing said... Agent: Anthony C Edwards

20100093050 - Biotechnical and microbiological production method and equipment: A method and an apparatus enabling the simultaneous cultivation and product formation in both aerobic and anaerobic conditions of microbes or other production organisms in the same bioreactor. The used microbes may be facultatively anaerobic bacteria, for example.... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20100093051 - Light regulated transcription system for use in prokaryotic organisms: A process for regulating transcriptional activity of a gene is provided. The process comprises introducing genetic material into an organism, placing a gene downstream of a light-regulated promoter within the organism having a light responsive element and subjecting the organism to an exogenous light source. The genetic material is selected... Agent: Bose Mckinney & Evans LLP

20100093052 - Magnetic cell separation: Systems and methods are provided separating a first group of cells from a mixture of at least first and second groups of cells in a suspending fluid. The system includes an annular flow channel and at least one magnetic element positioned around the exterior of the annular flow channel as... Agent: Wood, Herron & Evans, LLP

20100093053 - Microcarriers for stem cell culture: We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50... Agent: Swanson & Bratschun, L.L.C.

20100093054 - Novel methods for recovery of leaf proteins: A novel method for processing soluble plant leaf proteins is described. While leaf proteins are considered potentially the most abundant source of protein in nature, the lack of efficient processing techniques for leaf proteins has limited their commercial use. The method described in this patent provides a means of extracting... Agent: Marlana Titus Nash & Titus

20100093055 - Remedy for diabetes: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100093056 - Antibodies that bind dkk-related proteins: Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule... Agent: Amgen Inc. Law Department

20100093057 - Compositions and methods to prevent cancer by stabilizing p53 through non mdm2-mediated pathways: The present invention relates to compositions and methods comprising chemopreventive agents that may be cupredoxin(s) or variants, derivatives and structural equivalents of cupredoxins, and at least one other chemopreventive agent. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The compositions of... Agent: Don J. Pelto Sheppard, Mullin, Richter & Hampton LLP

20100093058 - High transgene expression of a pseudotyped adeno-associated virus type: The present invention related to methods and compositions comprising recombinant vectors comprising chimeric capsids and recombinant pseudotyped vectors with non-native capsid protein(s). The recombinant vectors of the invention confer an altered tropism that permits selective targeting of desired cells.... Agent: Nutter Mcclennen & Fish LLP

20100093059 - Method for the preparation of sulfated cellulose membranes and sulfated cellulose membranes: The present invention relates to methods for the preparation of functionalized sulfated cellulose membranes. In particular, the present invention relates to the preparation of sulfated cellulose membranes under specific reaction conditions allowing to provide a sulfated cellulose membrane useful for pseudo-affinity purification. In another aspect, the present invention relates to... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20100093060 - Growth of microorganisms in cellulosic media: The present invention provides novel methods of growing of microorganisms in cell culture media comprising cellulosic material as a carbon source. The present invention further provides novel cell culture media cellulosic material as a carbon source. In certain embodiments, inventive cell culture media substantially lack a carbon source other than... Agent: Choate, Hall & Stewart LLP

20100093061 - Assays for improved fungal strains: The invention relates to methods for obtaining improved strains of filamentous ascomycete fungus, such as Trichoderma reesei, and the product of said method. The method includes contacting ascomycete cells comprising a reporter gene construct with a mutagen, wherein said reporter gene construct comprises a promoter operably linked with a reporter... Agent: Danisco US Inc. Attention: Legal Department

20100093062 - Transfection system for perkinsus species: A Perkinsus heterologous expression system that is useful to produce recombinant proteins, e.g., from related parasites of medical and veterinary relevance. This expression system increases the number of genes that can be targeted for protein structure/function studies, production of antigens, and in vitro drug screening. Also described is a transfection... Agent: Intellectual Property / Technology Law

20100093064 - Metagenomic functional selection: Methods and compositions for directly selecting a nucleic acid sequence that confers resistance to an inhibitory compound are provided. Methods and compositions for decontaminating contaminated substances are provided. Microorganisms having resistance to an inhibitory compound are also provided.... Agent: Banner & Witcoff, Ltd.

20100093063 - Method for the treatment of ground water and soils using dried algae and other dried mixtures: The induction of reducing conditions and stimulating anaerobic process through the addition of dried micro-blue green algae (Spirulina, Arthorospira Platensis, Arthrospria Maxima, Aphanizomen flos-aquae, and chlorella) and seaweed (Dulse, Nori, and Kelp) to accomplish accelerated dechlorinization of soil and groundwater contaminated with chlorinated solvents and heavy metals.... Agent: Gregory J. Gore

20100093065 - Single cell microinjection using flexible and compliant fluidic channels and electroosmotic dosage control: A microinjection device for injecting a target cell with a reagent. The microinjection device includes a flexible substrate; a target supply channel formed in the flexible substrate for receiving the target cell; a reagent supply channel formed in the flexible substrate for receiving the reagent; a suction capillary mounted within... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

  
04/08/2010 > patent applications in patent subcategories. category listing, related patent applications

20100086907 - Fluidics based pulsatile perfusion preservation device and method: In one embodiment, a preservation apparatus is described that includes a storage compartment. The storage compartment is configured to hold an organ or tissue and a preservation fluid. A cover assembly is configured to engage the storage compartment. The cover assembly includes a support element, wherein the support element together... Agent: Meyertons, Hood, Kivlin, Kowert & Goetzel, P.C.

20100086908 - Methods for the detection of respiratory viruses: The present invention relates generally to the field of nucleic acid detection and more specifically to the detection of human respiratory viruses in a patient sample. In some aspects, the invention relates to the detection of multiple respiratory viral groups, including rhinovirus, respiratory syncytial virus, parainfluenza virus, influenza virus, metapneumovirus,... Agent: Foley & Lardner LLP

20100086922 - Assessment of chromosomal alterations to predict clinical outcome of bortezomib treatment: Disclosed herein are chromosomal loci associated with clinical outcome to treatment for multiple myeloma. Genome-wide changes observed in myeloma relate to prognosis and treatment response to a proteasome inhibitor. Compositions and methods are provided to assess DNA copy number at corresponding to markers of loci and genes found thereon which... Agent: Millennium Pharmaceuticals, Inc.

20100086912 - Azgp gene single nucleotide polymorphisms (snps): The present invention provides single nucleotide polymorphisms and haplotypes in the AZGP1 gene that can be used for determining the predisposition of an individual to obesity.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100086932 - Bladder cancer diagnosis and/or prognosis method: The present invention relates to an in vitro non-invasive bladder cancer diagnosis and/or prognosis method based on the detection and quantification in bladder fluids of the gene expression of certain genes and/or combinations thereof acting as genetic markers of said disease. A bladder cancer diagnosis and/or prognosis kit based on... Agent: Knobbe Martens Olson & Bear LLP

20100086927 - Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers: Intermediates and methods for forming activated metal complexes bound to surfaces on oxide layers, immobilizing beads to the modified surface and articles produced thereby are described. Hydroxyl groups on the oxide surfaces are reacted with a metal reagent complex of the formula Y(L-Pol)m, where Y is a transition metal, magnesium... Agent: Life Technologies Corporation C/o Intellevate

20100086929 - Detection of analytes: (ii) a liquid composition having a liquid and nanostructures, each of the nanostructures comprising a core material of a nanometric size surrounded by an envelope of ordered fluid molecules, the core material and the envelope of ordered fluid molecules being in a steady physical state.... Agent: Foley And Lardner LLP Suite 500

20100086915 - Detection of esr1 amplification in breast cancer: The present invention relates to an in-vitro method of identifying a tumor resulting from a proliferative breast disease as responsive to anti-estrogen treatment. Further, the invention relates to an in-vitro method of identifying a candidate patient with a proliferative breast disease as suitable for anti-estrogen treatment. In a further aspect,... Agent: Marshall, Gerstein & Borun LLP

20100086928 - Detection of organ rejection: The present invention features methods and compositions for the non-invasive detection of organ rejection using a microRNA score.... Agent: Edwards Angell Palmer & Dodge LLP

20100086919 - Devices and methods for immunoglobulin production: The present invention relates to devices and methods that are useful for screening and isolating cells that express a desired immunoglobulin. The present invention further relates to devices and methods that are useful in producing monoclonal antibodies from non-immortal cells (such as B cells) or immortalized cells (such as hybridoma... Agent: Ropes & Gray LLP

20100086921 - Genetic susceptibility variants of type 2 diabetes mellitus: Association analysis has shown that certain genetic variants are susceptibility variants for Type 2 diabetes. The invention relates to diagnostic applications of such susceptibility variants, including methods of determining increased susceptibility to Type 2 diabetes, as well as methods of determining decreased susceptibility to Type 2 diabetes in an individual.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100086936 - Hepatocyte precursor cell lines: The present invention is directed to methods for readily generating hepatocyte precursor cell lines that retain hepatocyte-specific functions after extensive in vitro culturing. The methods comprise isolating and culturing hepatocyte precursor cell lines under permissive culture conditions that suppress asymmetric cell kinetics and allow exponential growth of the precursor cells,... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20100086914 - High resolution, high throughput hla genotyping by clonal sequencing: The invention provides methods and reagent for performing full, multi-locus HLA genotyping for multiple individuals in a single sequencing run using clonal sequencing.... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20100086935 - Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles: A method provides an index that is indicative of the state of a subject, as to a biological condition, based on a sample from the subject. An embodiment of this method includes: deriving from the sample a profile data set, the profile data set including a plurality of members, each... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100086930 - Improved homogeneous luminescence bioassay: A homogenous bioassay including i) a first group containing a short lifetime fluorescent acceptor capable of energy transfer, and ii) a second group containing a quencher capable of energy transfer from an acceptor, with the first and second groups linked by at least a first linkage. The bioassay measures the... Agent: James C. Lydon

20100086917 - Isolated polynucleotides, nucleic acid constructs, methods and kits for localization of rna and/or polypeptides within living cells: An isolated polynucleotide comprising a first nucleic acid sequence which comprises two functionally compatible recognition sites for a site-specific recombination enzyme and a second nucleic acid sequence encoding a protein binding-RNA sequence is provided. Also provided are nucleic acid constructs, methods and kits for localization of an mRNA and/or a... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100086931 - Method for assaying action of antitumor agent using decrease in gene expression level as index: An object of the present invention is to provide a method, a probe, a primer, an antibody, a reagent, and a kit for assaying an action of a pladienolide derivative to a living subject. According to the present invention, there is provided a method for assaying an action of the... Agent: Fish & Richardson P.C.

20100086909 - Method for the prediction of individual disease course in sepsis: The invention relates to the use of gene expression profiles, obtained in vitro from a patient sample, for the generation of criteria for the prediction of an individual course of disease in sepsis. The invention is further of use for determining the probability of survival in sepsis, the assessment of... Agent: Patent Central LLC Stephan A. Pendorf

20100086926 - Method of characterizing sequences from genetic material samples: Among other aspects provided herein is a method describing the use of Single Nucleotide Polymorphism (SNP) genotyping microarrays to resolve whether genetic material (such as genomic DNA) derived from a particular individual is present in a genetic material mixture (such as a complex genomic DNA mixture) is disclosed. Furthermore, it... Agent: Knobbe Martens Olson & Bear LLP

20100086920 - Method to assess cancer susceptibility and differential diagnosis of metastases of unknown primary tumors: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different tumor markers in a serum sample, which can be used to screen for and determine susceptibility to cancer as well as for the differential diagnosis of metastases from an unknown primary tumor. It also discloses... Agent: Weili Cheng

20100086918 - Methods for high sensitivity detection of genetic polymorphisms: Multiplex PCR-based methods for detecting a variant polynucleotide having a nucleotide sequence differing from the wild-type nucleotide sequence of a nucleic acid molecule, wherein the variant polynucleotide is in a sample containing an excess of the wild-type nucleic acid molecule. The methods are particularly useful for detection of deletions from,... Agent: Dla Piper LLP (us)

20100086913 - Methods of identification using methylation of cpg: The present invention relates to the materials and methods for the identification of methylated nucleotides in samples of genomic DNA. The present invention also relates to methods of diagnosis of specific conditions by identification of specific methylated nucleotides.... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100086925 - Microfluidic structure for multi-assay and microfluidic device comprising the same: Exemplary embodiments relate to a microfluidic structure including: a plurality of sample chambers; a reaction chamber in which at least two types of materials, which respectively specifically react with at least two types of target materials, are immobilized; a detection chamber connected to the reaction chamber; a path connecting the... Agent: Sughrue Mion, PLLC

20100086916 - Oligonucleotide probes and uses thereof: The present invention provides a dually labeled oligonucleotide probe, methods of preparing and using the same. The subject probes are particularly useful for high-sensitive nucleic acid detection via hybridization assays including but not limited to template-directed polymerization reactions.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100086911 - Preventive/therapeutic agent for cancer: Identification of a novel target molecule for preventing/treating cancer and a preventive/remedy agent for cancer which targets the molecule, specifically, an agent for promoting the apoptosis in cancer cells and/or inhibiting the growth of cancer cells and a preventive/remedy agent for cancer, which comprise an antibody against a protein including... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100086933 - Sensor for detecting an analyte: The present invention relates to a sensor for detecting an analyte, to a sensor array, and to a method of detecting an analyte using the sensor of the invention.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100086910 - Surface-modified single-walled carbon nanotubes and methods of detecting a chemical compound using same: A method for surface modification of single walled carbon nanotubes. In one embodiment, the method includes the steps of providing a detergent solution, adding a plurality of single walled carbon nanotubes into the detergent solution, performing a first sonication to disperse the single walled carbon nanotubes in the detergent solution,... Agent: Morris Manning Martin LLP

20100086923 - Use of acetals for isolation of nucleic acids: The invention provides the use of water-miscible liquid cyclic acetals for adsorbing a nucleic acid to a solid phase such as a substrate with a silica surface. To this end, the invention also provides compositions comprising said acetals. Methods are disclosed and claimed to purify nucleic acids from samples, as... Agent: Roche Diagnostics Operations Inc.

20100086934 - Use of non-clonal chromosomal aberrations for cancer research and clinical diagnosis: A diagnostic method of determining tumorigenicity of a tissue specimen includes the steps of determining a magnitude of genome diversity in the tissue specimen, and diagnosing a likelihood of cancer in response to said step of determining the magnitude of genome diversity. The magnitude of genome diversity includes the determination... Agent: Rohm & Monsanto, PLC

20100086924 - Use of tde for isolation of nucleic acids: The invention provides the use of tetraethylene glycol dimethyl ether for adsorbing nucleic acids to solid phases such as those with silica surfaces. To this end, the invention also provides compositions comprising TDE. Methods are disclosed and claimed to purify nucleic acids from samples, as well as kits useful for... Agent: Roche Diagnostics Operations Inc.

20100086937 - method to detect treponema pallidum immunological markers for the diagnosis of syphilis: This invention discloses using SPR technology to qualitatively detect the presence of Treponema pallidum immunological markers in a serum sample, which can be used for the diagnosis of syphilis. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal... Agent: Weili Cheng

20100086942 - Compounds: The present invention relates to binding members, especially antibody molecules, for CXCL13. The binding members are useful for the treatment of disorders associated with CXCL13, including arthritic disorders such as rheumatoid arthritis.... Agent: Astrazeneca R&d Boston

20100086939 - Determination method for allergic disease: It is to provide a method for determining allergic diseases with a high sensitivity and accuracy which enables multilateral and global analysis with a minute amount of sample, even using body fluid other than blood such as saliva, nasal discharge and tears as a sample, particularly by suppressing nonspecific reaction... Agent: King & Spalding

20100086938 - Mass spectrometry of biological sample using immunoprecipitation: It is intended to provide an analysis method for a biological sample with clinical significance, which is a system being simple to such an extent that it can be applied to a clinical field, and capable of capping a molecule ionization suppression in mass spectrometry. Mass spectrometry of a biological... Agent: Cheng Law Group, PLLC

20100086941 - Methods for determining aged based accumulation of senescent cells using senescence specific dna damage markers: One disclosure provides a method for determining a senescence based disorder by detection of cells with senescence specific DNA damage markers which includes the step of providing a sample with one or more cells. It also includes the steps of identifying with immunodetection the presence of activated DNA damage response... Agent: Mccracken & Frank LLP

20100086940 - Polynucleotide encoding an autoantigen associated with endometriosis: This invention provides a polynucleotide encoding Repro-EN-1.0 and IB1, polypeptides associated with endometriosis. Auto-antibodies against Repro-EN-1.0 and IB1 have been found in subjects diagnosed with endometriosis. This invention also provides methods of using this polynucleotide and polypeptide.... Agent: Siemens Corporation Intellectual Property Department

20100086943 - Method for the detection of post-translational modifications: Method for the detection in homogeneous medium of a post-translational modification of a protein substrate catalyzed by a cell enzyme, characterized in that the post-translational modification reaction takes place in intact living cells, in that these cells comprise a heterologous expression vector coding for a fusion protein comprising the protein... Agent: Hunton & Williams LLP Intellectual Property Department

20100086948 - Ovarian cancer biomarkers and uses thereof: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of ovarian cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose ovarian cancer or permit the differential diagnosis of a pelvic mass as benign... Agent: Swanson & Bratschun, L.L.C.

20100086946 - Plgf, flt1 and endoglin for diagnosing angiogenic status in coronary artery disease: Described are methods for diagnosing the angiogenic status of a subject suffering from coronary heart disease comprising determining the amounts of placental growth factor or a variant thereof, endoglin or a variant thereof and soluble FLT1 or a variant thereof in a sample of a subject suffering from coronary heart... Agent: Roche Diagnostics Operations Inc.

20100086947 - Use of flow-cytrometric analysis to optimize cell banking strategies for cho cells: Production of biopharmaceuticals from CHO cells requires generation of master-, working- and post-production cell banks of high quality, partly under GMP conditions. An optimal cryopreservation strategy is needed for each new production cell line, particularly with regard to the desire to establish production processes that are completely devoid of serum... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100086949 - Retentate chromatography and protein chip arrays with applications in biology and medicine: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical... Agent: Townsend And Townsend And Crew, LLP

20100086950 - Ip-10 based immunological monitoring: The present invention relates to an immunological method and, more particularly, a method for measuring cell-mediated immune reactivity (CMI) in mammals based on the production of IP-10. The invention further discloses an assay and a kit for measuring CMI to an antigen using whole blood or other suitable biological samples.... Agent: Knobbe Martens Olson & Bear LLP

20100086951 - Pan-kinase activation and evaluation of signaling pathways: Methods and reagents are provided for determining the activation state of a signal transduction pathway signaling protein. There exists a need in the art for methods that can monitor the efficacy of a signal transduction inhibitor in a patient. Other needs exist for detecting and monitoring certain disease or disorders... Agent: Sterne Kessler Goldstein & Fox, P.l.l.c.

20100086944 - Methods and compositions for diagnosis and prognosis of renal artery stenosis: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects in the context of renal artery stenosis (RAS). In particular, the invention relates to using assays that detect NGAL, their use to diagnose RAS in subjects suffering from hypertension, and their... Agent: Wilson, Sonsini, Goodrich & Rosati

20100086945 - Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor: The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20100086952 - Assays for measuring phosphate modification enzyme activity: The present invention relates to assays that can measure the activity of enzymes that catalyze phosphate modifications, such as kinases, phosphatases, cyclases and phosphodiesterases. The assays can also be used to identify and screen for substances that modulate the activity of kinases, phosphatases, cyclases and phosphodiesterases.... Agent: Grant D. Green Patent Law Department

20100086953 - Blood coagulation assays: The invention relates to methods for determining the activity of a proteolytic coagulation factor of the blood coagulation cascade in a body fluid such as whole blood or plasma. A combination is provided in a reaction mixture. The combination comprises the sample and an activation agent for activating a proteolytic... Agent: Siemens Corporation Intellectual Property Department

20100086954 - Small volume in vitro analyte sensor and methods of making: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or... Agent: Abbott Diabetes Care Inc. Bozicevic, Field & Francis LLP

20100086956 - Detection of hiv-related proteins in urine: A method for detecting HIV infection in a mammal is disclosed. The method contains the steps of isolating exosomes from a urine sample of a mammal and detecting the presence of HIV-specific biomarker in said isolated exosomes. A method for diagnosing a mammal with an HIV-associated disease, in particular, HIV-associated... Agent: Morris Manning Martin LLP

20100086955 - Small molecule inhibitors of ghrelin o-acyltransferase: Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition.... Agent: Richard Aron Osman

20100086957 - Method for monitoring intracellular tyrosine phosphatase activity: The invention relates in general to tyrosine dephosphorylation. More specifically, the invention relates to methods and compositions for monitoring intracellular tyrosine dephosphorylation at the single cell level. The invention further relates to techniques that can be used as aid in the development of novel therapeutics, and monitor regulation of intracellular... Agent: Hogan & Hartson L.L.P.

20100086958 - Novel enzyme: Novel FDH enzymes are provided herein, including novel NADPH-specific and NADH-specific FDH enzymes. Additionally, methods are provided utilizing these novel enzymes in catalytic systems for in situ regeneration of NADPH or NADH. Further aspects of the invention relate to the definition and use of crystal structures of these novel enzymes.... Agent: Patent Network Law Group PLLC

20100086959 - Filtration unit and method for the microbiological analysis of liquid samples: The invention relates to a filtration unit, comprising a membrane filter that can be disposed on a filter support of a bottom part and an attachment that can be placed on the bottom part, wherein the membrane filter has a reinforcing edge, and wherein the membrane filter can be clamped... Agent: Casella & Hespos

20100086962 - Hematology controls and methods: An integrated hematology control and methods for making the same, including a first cellular component derived from a plurality of processed animal red blood cells other than human blood cells and a second cellular component derived from a plurality of processed animal red blood cells other than human blood cells... Agent: Dobrusin & Thennisch PC

20100086960 - Methods for the diagnosis of ovarian cancer health states and risk of ovarian cancer health states: The present invention describes a method for predicting a health-state indicative of the presence of ovarian cancer (OC). The method measures the intensities of specific small organic molecules, called metabolites, in a blood sample from a patient with an undetermined health-state, and compares these intensities to those observed in a... Agent: Nixon Peabody LLP - Patent Group

20100086961 - Small volume in vitro analyte sensor and methods of making: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or... Agent: Abbott Diabetes Care Inc. Bozicevic, Field & Francis LLP

20100086963 - Automated seed sampler and methods of sampling, testing and bulking seeds: An automated system for sampling seeds generally includes an automated sampler operable to remove a tissue sample from a seed, a seed tray configured to receive from the automated sampler the seed from which the tissue sample is removed, and a sample tray configured to receive the tissue sample removed... Agent: Harness, Dickey & Pierce, P.L.C

20100086964 - Apparatus and method for identifying at least one specimen slide: An apparatus and method for tagging a specimen slide are described. The apparatus comprises a receiving region for receiving at least one cassette magazine, a reading unit for reading the machine-readable coded information of a cassette identifier of a cassette, and a tagging unit for generating a machine-readable coded information... Agent: Alexander R Schlee SchleeIPInternational P.C.

20100086965 - Metabolic engineering of arabinose-fermenting yeast cells: The invention relates to an eukaryotic cell expressing nucleotide sequences encoding the ara A, ara B and ara D enzymes whereby the expression of these nucleotide sequences confers on the cell the ability to use L-arabinose and/or convert L-arabinose into L-ribulose, and/or xylulose 5-phosphate and/or into a desired fermentation product... Agent: Nixon & Vanderhye, PC

20100086966 - Feedback resistant acetohydroxy acid synthethase mutants: The present invention provides nucleotide sequences coding for acetohydroxy acid synthetase (AHAS) mutants, the mutated enzymes themselves and a process for the fermentative production of branched-chain amino acids using these enzymes in specific hosts in which genes which code for the modified acetohydroxy acid synthetase (AHAS) are expressed.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100086967 - Cell growth: The invention concerns the field of cell culture technology. It concerns a method of improving cell growth, especially the growth of biopharmaceutical producer host cells. The invention further concerns a method of producing proteins using the cells generated by the described method.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100086968 - Lactic acid bacteria strain and its use for the protection of food products: The present invention refers to a strain of Lactobacillus curvatusbacteria deposited in the Deutsche Sammlung von Mikroorganismen and Zellkulturen GmBH (DSMZ) under the accession number DSM 18775, as well as to compositions, cultures and food products comprising thereof. The strain of the invention is useful for preserving food products, especially... Agent: Foley And Lardner LLP Suite 500

20100086969 - Antibodies that bind to epha2 and methods of use thereof: Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.... Agent: Edell, Shapiro & Finnan, LLC

20100086970 - Thermus scotoductus nucleic acid polymerases: The invention provides nucleic acids and polypeptides for a nucleic acid polymerase from a thermophilic organism, Thermus scotoductus. The invention also provides methods for using these nucleic acids and polypeptides.... Agent: Life Technologies Corporation C/o Intellevate

20100086971 - Growth medium for clostridium histolyticum: The present invention provides improved media for the cultivation of Clostridium histolyticum and culture supernatants for the biotechnological production of collagenase enzymes. The nutrient media according to the invention comprise one or more peptones from a non-mammalian source, preferably plant-derived peptones. The media can additionally comprise fish gelatin. The invention... Agent: Roche Diagnostics Operations Inc.

20100086972 - Process for the production of biodegradable, functionalised polymer particles and use thereof as pharmaceutical supports: The invention relates to a method for producing biodegradable, functionalised polymer particles, and to the use of the same as medicament carriers.... Agent: Nixon & Vanderhye, PC

20100086973 - Glycosylate derivatives of mithramycin, method of preparation and uses thereof: The present invention provides compounds characterized by the formula (I), where each of the substituent radicals is described in the specification. The invention also describes the use of said compounds in the treatment of various diseases, including: cancer or tumoral processes in general, Paget's disease, hypercalcaemia, hypercalciuria and neurological diseases... Agent: Moore & Van Allen PLLC

20100086974 - Highly pure polysialic acid and process for preperation thereof: The instant invention provides highly pure Polysialic acid and process for preparation thereof.... Agent: Wolf Greenfield & Sacks, P.C.

20100086975 - Method and apparatus for amplification of nucleic acid sequences using immobilized dna polymerase: The present invention generally relates to methods and apparatuses for amplifying nucleic acid sequences using immobilized DNA polymerase. More particularly, it relates to methods and apparatuses useful for amplifying target nucleic acid sequences by forming a plurality of reaction regions in which polymerase chain reaction (PCR) can occur, positioning immobilized... Agent: Jhk Law

20100086976 - Method for decontaminating a solution with respect to unwanted nucleic acids: e

20100086977 - Pressure chamber clamp mechanism: In a high-density sequence detection system, an apparatus for transporting a microplate. A control system provides a thermocycler control signal to regulate a desired thermal output of a thermocycler block. A frame has a first side, a second side, and an opening that extends through the first side and the... Agent: Life Technologies Corporation C/o Intellevate

20100086978 - Increased isoprene production using the archaeal lower mevalonate pathway: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.... Agent: Morrison & Foerster LLP

20100086979 - Production of omega-3 fatty acids in microflora of thraustochytriales using modified media: The present invention relates to improved methods for the production of omega-3 fatty acids by microorganisms belonging to the microflora of Thraustochytriales using a modified composition of the culture medium. In particular, the invention is directed to a process for the production of omega-3 fatty acids by culturing microflora, such... Agent: Hoffmann & Baron, LLP

20100086981 - Compositions and methods for improved saccharification of biomass: Compositions and methods are provided for enhancing saccharification of biomass with one or more enzymes to enhance availability of substrates for fermentation by a microorganism. Microorganisms are also modified to enhance activity of one or more hydrolytic enzymes that are present endogenously in or are introduced heterologously into a host... Agent: Wilson, Sonsini, Goodrich & Rosati

20100086980 - Method for producing lactic acid: There is provided is a method for producing lactic acid from glycerol, which comprises culturing a specific bacterium capable of producing lactic acid in a culture medium containing glycerol, or making cells of the bacterium, processed cells of the bacterium or immobilized product thereof contact with glycerol.... Agent: Taylor Russell & Russell, P.C.

20100086982 - Process for the biological production of n-butanol with high yield: The present invention provides a method for the biological production of n-butanol at high yield from a fermentable carbon source. In one aspect of the present invention, a process for the conversion of glucose to n-butanol is achieved by the use of a recombinant organism comprising a host C. acetobutilicum... Agent: Pepper Hamilton LLP

20100086983 - Process for accelerated capture of carbon dioxide: The present invention generally relates to the removal of carbon dioxide from a gas stream, particularly a flue gas, hydrogen gas from a reformer, natural gas, or gas from a cement kiln. Immobilized enzymes for use in carbon capture and other systems are also disclosed.... Agent: Senniger Powers LLP

20100086984 - Optoinjection methods: Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse... Agent: Knobbe Martens Olson & Bear LLP

20100086985 - Nucleic acid and corresponding protein entitled 205p1b5 useful in treatment and detection of cancer: A novel gene (designated 205P1B5) and its encoded protein are described. While 205P1B5 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in prostate cancer. Consequently, 205P1B5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 205P1B5 gene or fragment thereof, or its encoded protein... Agent: Agensys C/o Morrison & Foerster LLP

20100086986 - Nitrilases and methods for making and using them: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.... Agent: Verenium Corporation Intellectual Property Department

20100086987 - Surface treated calcium carbonate and its use in waste water treatment: The present invention relates to a process for the purification of water, wherein a surface-reacted natural calcium carbonate is brought into contact with the water to be purified, the surface-reacted natural calcium carbonate being the reaction product of a natural calcium carbonate with an acid and carbon dioxide, which is... Agent: Amster, Rothstein & Ebenstein LLP

20100086988 - Novel lactic acid bacteria: The present invention relates to bacteria of a genus Lactococcus having bacteriological properties of: (1) fermentability which curdles a 10% (W/W) reconstituted skim milk medium when cultivated at a temperature of 25° C. to 37° C. for 16 hours; (2) Bifidobacterium longum growth-promoting properties which lead to a viable count... Agent: Wood, Herron & Evans, LLP

20100086989 - Mutant glucose dehydrogenase: A mutant glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence of SEQ ID NO: 3 including substitution, deletion, insertion or addition of one or more amino acid residues other than the amino acid residue at the 365th position and having glucose... Agent: Knobbe Martens Olson & Bear LLP

20100086990 - Apparatus and method for nucleic acid amplification: The present invention provides apparatus (1) for conducting sequential nucleic acid amplification reactions. The apparatus (1) comprises a platform (2) having a sample compartment (5) and a plurality of reaction compartments (10). The sample compartment (5) is adapted to receive a fluid sample for conducting a first amplification reaction and... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20100086991 - Integrated microfluidic device with reduced peak power consumption: An integrated microfluidic device having a number of chambers (11-MN) for heating a fluid, a number of electrical heating elements (R) for heating different ones of the chambers, a controller for controlling the heating elements to vary a temperature of the fluid in the chambers repeatedly through a cycle of... Agent: Philips Intellectual Property & Standards

20100086992 - Biosensor, biosensor chip and method for producing the biosensor chip for sensing a target molecule: A biosensor chip for sensing a target molecule, includes: a substrate having a surface with a sensing area; and adhesive material for immobilizing a mollicute having a cell membrane on the sensing area. The chip may includes cell-resistant material for preventing the mollicute from being immobilized on those parts of... Agent: Sughrue Mion, PLLC

20100086993 - Cell detecting system and quantum dot measuring system: A cell detecting system is herein disclosed, wherein a complex is formed with a first bioactive ligand coupling to a quantum dot and recognizing and coupling to a first receptor of a cell and a second bioactive ligand coupling to a magnetic bead and recognizing and coupling to a second... Agent: Rosenberg, Klein & Lee

20100086994 - Structure of fermentation apparatus: A fermentation apparatus includes a fermentation tank, an air-hole mesh board, a lift-up cover, a blender and a pressurization equipment. An opening is above fermentation tank, an oblique-board base is at the bottom of the fermentation tank, and a feed opening and an air outlet are on the fermentation tank.... Agent: Roger H. Chu

20100086995 - Mhc class i peptide epitopes from the human 5t4 tumor-associated antigen: There is provided an MHC class I peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the amino acid sequence shown as SEQ ID No.2; (ii) the minimal epitope from the amino acid sequence shown as SEQ... Agent: Marshall, Gerstein & Borun LLP

20100086996 - Genetically modified human natural killer cell lines: The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD16 (FcγRIII-A), or other Fcγ or Fc receptors. The modified NK-92 cell can be further modified to concurrently express an associated accessory signaling protein, such as FcεRI-γ, TCR-ζ,... Agent: Cohen & Grigsby, P.C.

20100086997 - Trkb agonists for treating autoimmune disorders: Tyrosine receptor kinase (TrkB) agonists are provided for reducing leukocyte invasion of the central nervous system in autoimmune diseases such as multiple sclerosis. TrkB agonists include naturally-occurring agonists, such as NT4 and BDNF, as well as agonists such as agonist antibodies.... Agent: Pfizer Inc

20100086998 - Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100086999 - Differentiation of primate pluripotent cells to hepatocyte-lineage cells: Methods for differentiating primate pluripotent stem cells into hepatocyte-lineage cells are provided. In certain embodiments, the methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce hepatocyte-lineage cells. In certain embodiments, the population of cells produced by the methods is further enriched for hepatocyte-lineage... Agent: Law Office Of Salvatore Arrigo

20100087000 - Hepatic progenitor cell and method of isolating same: The isolation and proliferation of stem cells, particularly, hepatic stem cells continues to face technical hurdles. For example, colonies of stem cells, once isolated, tend to stop, or at least substantially slow, proliferating. The present invention provides a method to overcome this limitation, in part. The present invention also provides... Agent: Foley And Lardner LLP Suite 500

20100087001 - Anti-angiogenic cellular agent for cancer therapy: The invention provides cytokine induced killer (CIK) cell populations and methods of using CIK cells to treat cellular proliferative disorders. CIK cells generated in vitro include both bulk cultures and clones. Individual CIK cell clones display distinct but overlapping lytic specificities for tumor cells and endothelial cells in vitro. When... Agent: Ursula B. Day Henry M. Feiereisen, LLC

20100087002 - Methods, surface modified plates and compositions for cell attachment, cultivation and detachment: The present invention relates to the field of mammalian cell culture, and provides methods and compositions for cell attachment to, cultivation on and detachment from a solid substrate surface containing from at least about 0.5% N, a sum of O and N of greater than or equal to 17.2% and... Agent: Philip S. Johnson Johnson & Johnson

20100087003 - Device and method for the mechanical decollation of cells from a cell composite: A device for mechanically decollating cells from a cell composite, particularly a shear rotor, a cell isolation unit including such a shear rotor and a method for decollating cells from a cell composite. The aforementioned device includes a rotor having a rotor wall, which is concentrically arranged in a receptacle.... Agent: Hiscock & Barclay, LLP

20100087004 - Peptide-presenting surfaces for long-term culture of pluripotent cells: The present invention relates to methods of growing and maintaining pluripotent cells on an insoluble substrate that presents a peptide that binds to glycosaminoglycans, such as heparin. Specifically, methods of growing and maintaining pluripotent cells on substrates having a chemically defined surface presenting at least one peptide having basic amino... Agent: Quarles & Brady LLP

20100087005 - Auxiliary reagent for gene transfer: The present invention provides a means for introducing a gene of interest into a host cell with a higher degree of efficiency regardless of the gene transfer method employed and the type of the host cell. The auxiliary reagent for gene transfer of the present invention is characterized in that... Agent: Birch Stewart Kolasch & Birch

20100087006 - Use of fluorescent protein in cyanobacteria and algae for improving photosynthesis and preventing cell damage: This disclosure provides a method to reduce cell damage caused by near UV light absorption of algal or cyanobacterial cultures. The algal or cyanobacterial cells are transformed to express one or more fluorescent proteins, that absorb the harmful UV or near UV wavelengths and emits wavelengths that are photosynthetically more... Agent: John Dodds

  
04/01/2010 > patent applications in patent subcategories. category listing, related patent applications

20100081121 - Media and method for cell separation: The present invention relates to a separation media and a method for separation of cells from different cell sources, such as umbilical cord blood, using the separation media to obtain the desired cells, such as stem cells. The separation media has beads with a diameter of 200-500 μm and is... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100081122 - System and method for cultivating cells: A state of cells while being cultivated is ascertained and a feed medium suitable for the cell state is added for producing a target substance to be produced with a high yield. The system for cultivating cells of the invention includes a bioreactor/fermentor for cultivating cells to be cultivated, a... Agent: Antonelli, Terry, Stout & Kraus, LLP

20100081125 - amplification for solid phase immunoassay: The present invention is directed to immunoassays for detecting one or more target analytes in a fluid sample wherein the detection reaction occurs on a solid support and involves an amplification system. In particular, the invention is directed to making and using a test device having at least one site... Agent: Thompson Hine L.L.P. Intellectual Property Group

20100081123 - Devices and methods for analyte detection using distorted liquid crystals: The present invention provides devices and methods for detection of analytes based on measuring the anchoring strength of liquid crystals having distorted geometries. Methods for detecting an analyte in a sample include the steps of: (a) capturing an analyte on a substrate surface wherein the substrate surface defines an easy... Agent: Quarles & Brady LLP

20100081124 - Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples: The present invention relates to primers, probes, primer sets, primer and probe sets, methods and kits for detecting human papillomaviruses, human beta globin sequences and human papillomaviruses and human beta globin sequences in a test sample.... Agent: Vysis, Inc Patent Department

20100081126 - Process for designing inhibitors of influenza virus structural protein-1: Disclosed are methods and compositions useful in identifying inhibitors of influenza virus, such as influenza A and B virus. Also disclosed are methods for preparing compositions for administration to animals, including humans infected with or to protect against influenza virus.... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20100081127 - System and method of chemical imaging using pulsed laser excitation and time-gated detection to determine tissue margins during surgery: System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain... Agent: Chemimage Corporation

20100081134 - Bio-barcode based detection of target analytes: The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes reporter oligonucleotides as biochemical barcodes for detecting multiple protein structures or... Agent: Gregory T. Pletta Nanosphere, Inc.

20100081142 - Biomarkers for kidney diseases and method for using same: The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting,... Agent: Occhiuti Rohlicek & Tsao, LLP

20100081132 - Biosensors and biosensing incorporating rf and microwave rediation: Devices capable applying microwave and RF electromagnetic radiation to specific molecular interactions between a capture molecule and a target analyte and capable of sensing the specific molecular interaction are provided. Specific molecular interactions include, for example, specific recognition events such as, receptor-ligand, antigen-antibody, DNA-protein, sugar-lectin, RNA-ribosome, and enzyme substrate interactions... Agent: Intel Corporation C/o Cpa Global

20100081140 - Chemically cleavable phosphoramidite linkers for sequencing by ligation: Linkers and methods for determining a nucleotide sequence of a reference oligonucleotide are provided.... Agent: Banner & Witcoff, Ltd.

20100081137 - Click chemistry for the production of reporter molecules: The present invention relates to methods for producing reporter molecules suitable for the detection of analytes, e.g. nucleic acids. Further, the present invention relates to methods and regions for detecting analytes.... Agent: Brinks, Hofer, Gilson & Lione

20100081136 - Crtac as a biomarker, therapeutic and diagnostic target: The invention provides CRTAC, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The... Agent: Banner & Witcoff, Ltd.

20100081145 - Detecting prostate cancer: Methods and kits for detecting prostate cancer in urine samples include detecting the methylation status of various genes.... Agent: Philip S. Johnson Johnson & Johnson

20100081129 - Genemap of the human genes associated with crohn's disease: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility... Agent: Dowell & Dowell P.C.

20100081141 - Genome-wide chromosome conformation capture: The invention relates to the use of GCC (Genome Conformation Capture) technology in determining the three dimensional arrangement of an entire genome.... Agent: Hogan & Hartson L.L.P.

20100081131 - Identification of microbes using oligonucleotide based in situ hybridization: A method of sample analysis is provided. In certain embodiments, the method may comprise: a) contacting a sample comprising a microbe with a set of at least two labeled oligonucleotides under in situ hybridization conditions to produce a contacted sample, where the labeled oligonucleotides i. hybridize to different RNA molecules... Agent: Agilent Technologies Inc.

20100081139 - Method for detection of presence of target polynucleotide in samples: A method for detecting the presence of a target polynucleotide in a sample, including providing a mixture of the sample and target binding agent and measuring a signal from the mixture, where the target binding agent is capable of assuming a first position where the target binding agent is not... Agent: James C. Lydon

20100081133 - Methods of detecting root knot nematodes: The present invention relates to a method of testing a sample for the presence of a Meloidogyne nematode, said method comprising the step of analyzing the nucleic acid in said sample for the presence of an rRNA gene of a Meloidogyne nematode, or the transcription product thereof, or a fragment... Agent: Swanson & Bratschun, L.L.C.

20100081130 - Multifunctional particles providing cellular uptake and magnetic motor effect: Preparation of novel multifunctional particles and nanomaterials having a useful combination of magnetic and optical properties and biocompatibility. The internalization efficiencies in various in vitro cell studies have been investigated, and the external magnetic motor effect on the floating cells internalized with magnetic nanoparticles were clearly observed, for the first... Agent: Customer No. 70416 Perkins Coie LLP

20100081138 - Nucleotide sequences for the detection of enterohaemorrhagic escherichia coli (ehec): Nucleic sequences of plasmid origin are isolated from bacteria of the enterohaemorrhagic Escherichia coli group (EHEC) and used for the identification of EHEC(s), especially those possessing the genes encoding the virulence factors enterohaemolysin and intimin, and more particularly the specific detection of serotype O157:H7, and in detection kits.... Agent: Jacobson Holman PLLC

20100081144 - Point-of-care fluidic systems and uses thereof: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100081143 - Preparations, compositions, and methods for nucleic acid sequencing: Preparations, compositions and methods of sequencing nucleic acids are provided. The preparations, methods and compositions employ multiple priming sites on a target nucleic acid and typically utilize single molecule sequencing processes to identify sequence portions of the target which are then assembled to obtain the sequence of the target.... Agent: Pacific Biosciences Of California, Inc.

20100081128 - Self-assembled single molecule arrays and uses thereof: The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are... Agent: Morgan, Lewis & Bockius, LLP (sf)

20100081135 - Single nucleotide polymorphisms and use of same predicting male- specific prenatal loss: The present invention is directed to a panel of single nucleotide polymorphisms (SNPs) in specific genes that serve as biomarkers for sex-specific prenatal loss of a conceptus or embryo. There is provided herein methods and reagents for assessing the specific SNPs in those genes. The method useful in applying these... Agent: Medical Diagnostic Laboratories, LLC

20100081146 - Method of reducing the sensitivity of assay devices: A flow-through assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a scavenging zone that contains a capture reagent for the analyte of interest. The capture reagent may capture a quantity of the analyte that is less than... Agent: Dority & Manning, P.A.

20100081150 - Methods for generating host cells: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100081149 - Novel oxidized ldl complex and method for detection thereof: Serum amyloid P component, oxidized LDL and β2-glycoprotein I can together form a complex. The presence of a disease such as hyperlipemia and atherosclerosis can be determined by detecting the complex by using either one of an anti-serum amyloid P component antibody and an anti-β2-glycoprotein I antibody.... Agent: Swanson & Bratschun, L.L.C.

20100081151 - Biomarkers for early detection of ovarian cancer: Biomarker proteins that can be used in the diagnosis of early-stage ovarian cancer (OC) are described. The biomarker panels not only permit the distinction of patients with ovarian neoplasia (benign or malignant) from normal subjects, but they also allow the identification of patients with early-stage (stage I/II) ovarian cancer from... Agent: Karen S. Canady Canady & Lortz LLP

20100081147 - Human catechol-o-methyltransferase (comt) assay: Disclosed is an assay (method) to quantify the amounts of catecholamine-O-methyltransferase (COMT) protein in samples, such as extracts from cell cultures, body fluids, tissues, and environmental samples. It uses novel agents (anti-NE, COMT-NE, or COMT-epitope-NE) in combination with two previously described agents (anti-COMT and COMT) in a competitive ELISA system... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100081148 - Urinary biomarkers to predict long-term dialysis: This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the... Agent: Peter G. Carroll Medlen & Carroll, LLP

20100081152 - Small volume in vitro analyte sensor and methods of making: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or... Agent: Abbott Diabetes Care Inc. Bozicevic, Field & Francis LLP

20100081153 - Cancer associated protein kinases and their uses: Detection of expression of the provided protein kinase in cancers is useful as a diagnostic, for determining the effectiveness of drugs, and determining patient prognosis. The encoded polypeptides further provides a target for screening pharmaceutical agents effective in inhibiting the growth or metastasis of tumor cells.... Agent: Bozicevic, Field & Francis LLP

20100081154 - Identification and use of bacterial [2fe-2s] dihydroxy-acid dehydratases: A group of bacterial dihydroxy-acid dehydratases having a [2Fe-2S] cluster was discovered. Bacterial [2Fe-2S] DHADs were expressed as heterologous proteins in bacteria and yeast cells, providing DHAD activity for conversion of 2,3-dihydroxyisovalerate to α-ketoisovalerate or 2,3-dihydroxymethylvalerate to α-ketomethylvalerate. Isobutanol and other compounds may be synthesized in pathways that include bacterial... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100081155 - Fluorescence polarization assays for determining clostridial toxin activity: The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage... Agent: Allergan, Inc.

20100081156 - Fluorescence polarization assays for determining clostridial toxin activity: The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage... Agent: Allergan, Inc.

20100081157 - Fret protease assays for clostridial toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Allergan, Inc.

20100081158 - Fret protease assays for clostridial toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Allergan, Inc.

20100081164 - Biochemical markers for acute pulmonary embolism: The present invention relates to a method of differentiating between a singular and a multiple lung embolism in a subject suspected to suffer from acute lung embolism comprising determining the amount of NT-proBNP in a sample of a subject suspected to suffer from acute lung embolism and comparing the amount... Agent: Roche Diagnostics Operations Inc.

20100081163 - Ion channel assay methods: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a... Agent: Knobbe Martens Olson & Bear LLP

20100081160 - Method for diagnosing multiple sclerosis: Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100081162 - Method of evaluating antiwrinkle substance and method of assessing the skin: It is intended to provide a method whereby the skin conditions (for example, loss in the skin elasticity, wrinkle formation possibility, insufficient tightness in dermal collagen fiber bundles, or the like) can be exactly and conveniently assessed. It is also intended to provide a method whereby the wrinkle-improvement effect of... Agent: Knobbe Martens Olson & Bear LLP

20100081159 - Profiling reactive oxygen, nitrogen and halogen species: This invention provides methods, kits and systems which permit simultaneous profiling of multiple reactive oxygen species (ROS), reactive nitrogen species (RNS) and/or reactive halogen species (RHS) including reactive chlorine species (RCS) and/or reactive bromine species (RBS) through multiplexed fluorescence detection of three or more indicator probes in live cells or... Agent: Enzo Life Sciences, Inc. C/o Enzo Biochem, Inc.

20100081161 - Reagent for diluting blood sample and method for measuring mean corpuscular volume by using the same: The invention provides a reagent for diluting a blood sample, comprising water, polyoxyethylene alkyl ether having a hydroxyl value of 52 to 60, and an osmo-regulator for regulating the osmotic pressure of the reagent in the range of 150 to 400 mOsm/kg, as well as a method for measuring the... Agent: Sughrue Mion, PLLC

20100081165 - Self-contained biological indicator: The disclosed invention provides a self-contained sterilization indicator for evaluating the effectiveness of a sterilization process. The sterilization indicator includes a cap configured for housing a growth medium, the cap being mountable on a container that contains a concentration of microorganisms. The cap comprises an inner chamber for housing the... Agent: Renner Otto Boisselle & Sklar, LLP

20100081166 - Microbial detection assembly: A microbial detection assembly is disClosed which includes a tubular body, a pierceable septum, and a plunger. The tubular body defines a longitudinal axis and has a first end and a second end. The pierceable septum is configured to seal the first end of the tubular body. The plunger head... Agent: Tyco Healthcare Group Lp

20100081167 - Method and system for pretreatment of tissue slides: The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to... Agent: Dako/finnegan, Henderson, LLP

20100081168 - Use of acid stable protease in animal feed: The present invention relates to acid-stable proteases homologous to those derived from strains of the genus Nocardiopsis, their use in animal feed, feed-additives and feed compositions containing such proteases, and methods for the treatment of vegetable proteins using such proteases.... Agent: Novozymes North America, Inc.

20100081171 - Method for lyophilizing competent cells: This invention relates to a method for producing cells which are competent for transformation and which may be stably stored for extended periods of time at various temperatures. The method involves growing cells in a growth conducive medium, rendering said cells competent, and lyophilizing said competent cells. The invention further... Agent: Life Technologies Corporation C/o Intellevate

20100081170 - Methods for producing soluble membrane-spanning proteins: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in... Agent: Morrison & Foerster LLP

20100081169 - Production of a lipid acyltransferase from transformed bacillus licheniformis cells: The present invention relates to a method for the production of a lipid acyltransferase comprising the steps of: (i) providing a Bacillus licheniformis cell; (ii) transforming the Bacillus licheniformis cell with a heterologous nucleotide sequence encoding a lipid acyltransferase; and (iii) expressing the lipid acyltransferase in the cell under the... Agent: Frommer Lawrence & Haug

20100081172 - N-glycans and uses thereof: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100081173 - Microorganism producing inosine and method of producing inosine using the same: The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating... Agent: Swanson & Bratschun, L.L.C.

20100081176 - Enzyme-containing capsules and nucleic acid amplification kits: An object of the present invention is to provide an enzyme-containing capsule which is employed for deactivating, from a sample, the proteins in the sample and then amplifying a nucleic acid in the sample, a kit for the amplification of nucleic acid which comprises the enzyme-containing capsules, and a method... Agent: Townsend And Townsend And Crew LLP

20100081175 - Enzyme-containing gels and nucleic acid amplifying kits: The present invention is aimed at providing an enzyme-containing gel which is employed for deactivating, from a sample containing proteins and nucleic acids, easily and simply the proteins in the sample and then amplifying a nucleic acid in the sample, a kit for the amplification of nucleic acid which comprises... Agent: Townsend And Townsend And Crew LLP

20100081174 - Methods for detection of methyl-cpg dinucleotides: The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20100081177 - Decreasing rubisco content of algae and cyanobacteria cultivated in high carbon dioxide: Algae and cyanobacteria are genetically engineered to have lower RUBISCO (ribulose-1,5-bisphosphate carboxylase/oxygenase) content in order to grow more efficiently at elevated carbon dioxide levels while recycling industrial CO2 emissions back to products, and so as not to be able to grow outside of cultivation.... Agent: Dodds & Associates

20100081178 - Modified photosynthetic microorganisms for producing triglycerides: This disclosure describes genetically modified photosynthetic microorganisms, including Cyanobacteria, that contain one or more exogenous genes encoding a diacylglycerol acyltransferase, a phosphatidate phosphatase, and/or an acetyl-CoA carboxylase, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides.... Agent: Seed Intellectual Property Law Group PLLC

20100081179 - Increased heterologous fe-s enzyme activity in yeast: Yeast strains were engineered that have increased activity of heterologous proteins that require binding of an Fe—S cluster for their activity. The yeast strains have reduced activity of an endogenous Fe—S protein. Activities of heterologous fungal or plant 2Fe-2S dihydroxy-acid dehydratases and Fe—S propanediol dehydratase reactivase were increased for increased... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100081180 - Method for producing an organic acid: An organic acid is produced by allowing a bacterium which has an ability to produce an organic acid and has been modified so that expression of yidE gene is enhanced, or a product obtained by processing the bacterium, to act on an organic raw material in a reaction mixture containing... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100081181 - Method for conversion of oil-containing algae to 1,3-propanediol: The present invention relates to a process for oxidizing renewable polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to a malonic acid intermediate which is subsequently reduced to 1,3 propanediol (PDO).... Agent: Darby & Darby P.C.

20100081183 - Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria: e

20100081182 - Enhanced iron-sulfur cluster formation for increased dihydroxy-acid dehydratase activity in lactic acid bacteria: Lactic acid bacteria expressing dihydroxyacid dehydratase polypeptides with increased specific activity are disclosed. The lactic acid bacteria comprise recombinant genes encoding iron-sulfur cluster forming proteins.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100081184 - Method for evaluation, design and optimization of in-situ bioconversion processes: A method for the evaluation, design and optimization of in-situ bioconversion processes for the conversion of carbon to methane and other useful gases and liquids. The method utilizes a comprehensive computer simulation model for accurately simulating the physical and dynamic conditions in a subterranean carbon-bearing formation and the effects of... Agent: Carella, Byrne, Cecchi, Olstein, Brody & Agnello

20100081185 - System and method for photodynamic cell therapy: The invention can be characterized as method for stimulating or inhibiting gene expression by photomodulating living cells using a source of narrowband multichromatic electromagnetic radiation. The cells may include, among others, nerve cells, skin cells, retinal cells, heart cells, stem cells, brain cells, cells found in human organs, cells found... Agent: Nelson Mullins Riley & Scarborough LLPIPDepartment

20100081186 - Self-decontaminating metal organic frameworks: A self-decontaminating metal organic framework including an acid linked to a metal producing a metal organic framework configured for the sorption of chemical warfare agents and/or toxic industrial chemicals, the metal organic framework including reactive sites for the degradation of the agents and chemicals.... Agent: Iandiorio Teska & Coleman

20100081187 - Recombinant vitamin k dependent proteins with high sialic acid content and methods of preparing same: Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized. The improved Factor IX has at least 62% N-glycosylation with 3 or 4 sialic acid residues and improved bioavailability and pharmokinetic properties.... Agent: Knobbe Martens Olson & Bear LLP

20100081188 - Apparatus for detecting drugs in a beverage: A test kit for detecting the presence of one or more drugs in a beverage comprising a support having a plurality of detector strips attached thereto. Drugs to be detected are e.g. benzodiazepines, gamma hydroxy butyrate (GHB), Ketamines, Ectasy (MDMA), cocaine barbiturates, opiates, cannabis and flunitrazepam (Rohypnol®).... Agent: Sonnenschein Nath & Rosenthal LLP

20100081189 - Sample chamber: The invention relates to a sample chamber for testing samples, comprising a bottom plate and a cover plate connected thereto, a sample reservoir for receiving a liquid and/or a sample to be tested, and a contact electrode which is arranged entirely in the bottom plate, in the cover plate or... Agent: Ip Strategies

20100081190 - Histological facilitation systems and methods: Systems, methods, and other modalities are described for generating or otherwise handling images or other data indicating (a) an extraction of chemically treated tissue frozen in vivo, (b) a treatment of a tissue sample in a chamber extended into tissue of an organism, and/or (c) cells to which an optical... Agent: Searete LLC Clarence T. Tegreene

20100081191 - Anisotropic heat spreader for use with a thermoelectric device: A well block for use with a Polymerase Chain Reaction (PCR) Cycler may include a body for holding a plurality of specimen vials, a base for attaching the well block to a temperature control device, and a temperature plate coupled to the base. Further, the temperature plate may include an... Agent: Baker Botts L.L.P.

20100081194 - Cells having cardiac glycoside resistance: A recombinant Na+, K+-ATPase α1-subunit protein resistant to cardiac glycosides, e.g. oubain, is disclosed, as well as methods for its production and use. The resistance to cardiac glycosides are obtained by alterations in the region situated between and including the amino acids 65-133. Such recombinant protein and nucleic acid constructs... Agent: Morrison & Foerster LLP

20100081192 - Early prostate cancer antigens (epca), polynucleotide sequences encoding them, and their use: A novel prostate cancer marker is described that is found in cancerous and normal prostate cells of individuals that have prostate cancer but is not found in the prostate of individuals without prostate cancer. The marker also is present in normal tissue adjacent to tumor tissue in individuals having prostate... Agent: Foley And Lardner LLP Suite 500

20100081193 - Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis: Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100081195 - Modified host cells and uses thereof: The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.... Agent: Wilson, Sonsini, Goodrich & Rosati

20100081196 - Method for separating a volume of whole blood into at least three components: A method for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes... Agent: Caridianbct, Inc. Mail Stop: 810 1f2

20100081197 - In vivo modulation of neuronal transport: A method for visualizing an active synapse wherein said method comprises: (a) exposing cells forming the active synapse to a biomarker comprising at least fragment C of tetanus toxin and a reporter protein; and (b) visualizing the biomarker; wherein the accumulation of the biomarker into dendritic spines of the cells... Agent: Finnegan Henderson Farabow Garrett & Dunner, LLP

20100081198 - Method for the repair of mutated rna from genetically defective dna and for the specific destruction of tumor cells by rna trans-splicing, and a method for the detection of naturally trans-spliced cellular rna: Methods and products for the repair of genetically defective DNA in the region of a mutated exon, for the specific destruction of tumor cells, and for the identification of naturally trans-spliced RNA. The methods inter alia are based on the utilization of cellular RNA splicing components.... Agent: Fleit Gibbons Gutman Bongini & Bianco Pl

20100081200 - Formulations and methods for culturing stem cells: The present invention relates to a serum replacement formulation and to a culture medium suitable for the derivation, maintenance and differentiation of stem cells.... Agent: Sughrue Mion, PLLC

20100081199 - Generation of mature myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-cd34+cd43+cd45+progenitors: A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed.... Agent: Quarles & Brady LLP

20100081201 - Olig1 mini-promoters: Isolated polynucleotides comprising an OLIG1 promoter are provided, where an OLIG1 regulatory element is operably joined to an OLIG1 basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest,... Agent: Bozicevic, Field & Francis LLP

20100081202 - Process for facilitating nucleic acid transfer: o

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