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Chemistry: molecular biology and microbiology March listing by industry category 03/10

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
03/25/2010 > patent applications in patent subcategories. listing by industry category

20100075293 - Bioreactors, systems, and methods for vascularizing tissue constructs: A modular bioreactor is provided that includes an upper biochamber; a lower biochamber; and an intermediate biochamber that is positioned between the upper biochamber and the lower biochamber. Each biochamber of the bioreactor is in fluid communication with each other biochamber of the bioreactor and includes an interior wall, which... Agent: Stites & Harbison, PLLC

20100075294 - Novel cellular compositions and methods for their preparation: The present invention relates to novel cell (e.g., hepatocyte, etc.) compositions and methods for their preparation and use. In particular, the invention concerns methods of processing preparations of such cells so as to permit their repeated cryopreservation and thawing while retaining substantial viability. The invention also concerns preparations of cells... Agent: Loeb & Loeb, LLP

20100075295 - Novel cellular compositions and methods for their preparation: The present invention relates to novel cell (e.g., hepatocyte, etc.) compositions and methods for their preparation and use. In particular, the invention concerns methods of processing preparations of such cells so as to permit their repeated cryopreservation and thawing while retaining substantial viability. The invention also concerns preparations of cells... Agent: Loeb & Loeb, LLP

20100075296 - Thermal cycling by positioning relative to fixed-temperature heat source: A thermal cycling system and method are provided herein, The thermal cycling system for performing a biological reaction at two or more different temperatures comprises: a) a heat source for setting at a fixed temperature; b) a reaction vessel containing material upon which the biological reaction is to be performed;... Agent: Pyle & Piontek, LLC

20100075297 - Photosensitive polypeptide and methods of their production and use: Methods for producing polypeptides caged with a photolabile group on one or more backbone nitrogens are provided, in which the photolabile group is added to a growing polypeptide chain during polypeptide synthesis. Photosensitive polypeptides produced by the methods are described, as are methods of using such photosensitive polypeptides to assay... Agent: Amster, Rothstein & Ebenstein LLP

20100075300 - Arrayed detector system for measurement of anti-viral immune response: A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete locations on the surface of the substrate. Detection devices containing the sensor chip and methods of detecting anti-viral... Agent: Nixon Peabody LLP - Patent Group

20100075299 - Detection and use of antiviral resistance mutations: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral... Agent: Knobbe Martens Olson & Bear LLP

20100075298 - Method for rapid identification and quantification of microorganisms: Method for unamplified, selective identification of a microorganism comprising obtaining a sample comprising the microorganism, wherein the sample comprises unseparated genetic material of the microorganism; adding to the sample a molecular beacon comprising an nucleic sequence which is complementary to at least one nucleic acid sequence in the microorganism; and... Agent: Los Alamos National Security, LLC

20100075301 - Methods for generation of reporter phages and immobilization of active bacteriophages on a polymer surface: Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of E. coli 0157:H7 to be propagated in nonpathogenic E. coli, thereby eliminating the safety and security risks of propagation in E. coli 0157:H7. Provided are compositions and methods... Agent: Miller, Matthias & Hull

20100075317 - Airborne particulate sampler: An airborne particulate sampling device is disclosed. The device includes a conduit whose interior allows the flow of air through the device. The conduit, or at least its surface, is a conductor. The device also includes an electrode with a sharp tip or edge on or near the output side... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20100075307 - Analyte detection assays: The present invention provides methods, kits and compositions for the detection of an analyte. In the methods of the invention, a binding molecule coupled to a first polymerase is incubated with a modified polynucleotide template to form a copy of the modified polynucleotide template without any modified nucleotides. The unmodified... Agent: Agilent Techologies Inc

20100075330 - Apparatus and methods for parallel processing of micro-volume liquid reactions: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays... Agent: Edwards Angell Palmer & Dodge LLP

20100075302 - Assays for resistance to echinocandin-class drugs: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such... Agent: Fox Rothschild LLP

20100075319 - Blocking agents comprising non-natural nucleic acids and detection methods using such blocking agents: This invention relates to nucleic acid analog blocking agents that may reduce nonspecific interactions between components of a biological or chemical detection assay. The blocking agents may help to reduce the background observed in biological or chemical detection assays, such as in situ assays and blots, and may thus enhance... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100075311 - Cartridge system: A cartridge system includes a reagent component for storing one or more reagents and a processing component for processing the one or more reagents in an assay. The reagent component and the processing component are configured to be coupled together to form a cartridge. The reagent component and/or the processing... Agent: Knobbe Martens Olson & Bear LLP

20100075314 - Chemically-modified gold nanoparticles and methods for use in detecting target molecules: The invention provides stable bioconjugate-nanoparticle probes which are useful for detecting nucleic acids and other target analytes, e.g., proteins, and methods of preparing those probes.... Agent: Gregory T. Pletta Nanosphere, Inc.

20100075335 - Colorimetric method and kit for the detection of specific nucleic acid sequences using metal nanoparticles functionalized with modified oligonucleotides: The present invention relates to a colorimetric method for the detection of specific nucleic acids sequences, including mutations or single nucleotide polymorphisms within nucleic acid sequences, through the aggregation of nanoparticles functionalized with modified oligonucleotides, induced by an increase of the medium's ionic strength. Another aspect of the present invention... Agent: Cermak Kenealy Vaidya & Nakajima LLP

20100075325 - Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer: The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.... Agent: Mccarter & English, LLP Boston

20100075331 - Cpg island sequencing: The present invention is directed to a method for analyzing the methylation status of a genomic DNA sample, comprising the steps of (i) fragmenting said sample and enriching said sample for sequences comprising CpG islands, (ii) generating a single stranded DNA library, (iii) subjecting said sample to Bisulfite treatment, (iv)... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris, Glovsky & Popeo, P.C.

20100075305 - Detection of bacterium by utilizing dnaj gene and use thereof: Disclosed is a method for detecting the species of a bacterium in a simple manner. Specifically disclosed is a method for detecting the species of a bacterium, which can detect at least one bacterial species selected from Staphylococcus species, Streptococcus species, Klebsiella species, Escherichia species, Mycobacterium species, Legionella species, Vibrio... Agent: Oliff & Berridge, PLC

20100075313 - Device for the lysis of microorganisms present in an environmental or clinical sample and the extraction of nucleic acids from said microorganisms for analysis: The present invention relates to a cartridge which can be positioned inside an air collection means and receive a means for recovering nucleic acids, said cartridge being substantially cylindrical and comprising a microorganism retaining zone, said retaining zone comprising microorganism lysis means. The invention also relates to a device for... Agent: Oliff & Berridge, PLC

20100075332 - Engineering polymerases and reaction conditions for modified incorporation properties: Provided are methods for enhanced sequencing of nucleic acid templates. Also provided are reaction conditions that increase branching fractions during polymerization reactions. Also provided are compositions comprising modified recombinant polymerases that exhibit branching fractions that are higher than the branching fractions of the polymerases from which they were derived. Provided... Agent: Quine Intellectual Property Law Group, P.C.

20100075328 - Immobilized nucleic acid complexes for sequence analysis: Provided are methods for sequencing a nucleic acid that include fixing a template to a surface through a template localizing moiety and sequencing the nucleic acid with a sequencing enzyme, e.g. a polymerase or exonuclease. The sequencing enzyme can optionally be exchanged with a second sequencing enzyme, which continues the... Agent: Pacific Biosciences Of California, Inc.

20100075309 - Intermittent detection during analytical reactions: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred... Agent: Pacific Biosciences Of California, Inc.

20100075327 - Intermittent detection during analytical reactions: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred... Agent: Pacific Biosciences Of California, Inc.

20100075321 - Labeled compound and detection method using the same: A labeled compound is so designed that an aromatic tertiary amine compound is bondable with a biomolecule. One of S1 and S2 contains a group bound with a molecular chain 10 (e.g. an oligonucleotide) capable of binding with a biomolecule or a reactive group covalently binding with a reactive group... Agent: K&l Gates LLP

20100075306 - Method for diagnosis of and following a bacterial vaginosis by molecular quantification: The present invention relates to a method for in vitro diagnosis and follow-up of vaginal bacterial flora status in relation to the presence of bacterial vaginosis, and for monitoring its treatment where applicable, wherein the presence of bacterial vaginosis or failure of on-going treatment is determined if the concentrations of... Agent: Oliff & Berridge, PLC

20100075316 - Method for identifying altered vitamin d metabolism: A method is provided for identifying an individual as having altered vitamin D metabolism comprising analyzing a biological sample from the individual for the presence of CYP24 SNPs and/or aberrantly spliced CYP24 mRNA. The presence of the SNPs and/or the aberrantly spliced CYP24 mRNA indicates that the individual has altered... Agent: Hodgson Russ LLP The Guaranty Building

20100075318 - Method of determining the haplotype of multiple allelic genes: In amplifying a region containing two allelic genes, the polymorphism of one of the allelic genes is positioned at or near the 3′ end of an amplification primer, so that the chain would extend only from one of the two primers, one that matches the mutant type nucleotide(s) and one... Agent: Fitzpatrick Cella Harper & Scinto

20100075333 - Method of determining the risk of scoliosis: A method for determining the risk for developing a scoliosis comprising monitoring osteopontin (OPN) expression in a sample from a subject over time; wherein an OPN expression that increases in the subject sample over time is indicative that the subject is at risk for developing a scoliosis.... Agent: Klarquist Sparkman, LLP

20100075322 - Methods and compositions for identifying mycotoxins and fungal species: The invention relates to a method of testing for a mycotoxin in patient tissue or body fluid and testing for a fungal species in the patient tissue or body fluid. The method can also be used to determine if a patient is at risk for or has developed a disease... Agent: Barnes & Thornburg LLP

20100075310 - Methods for microorganism detection and identification: Methods for detecting and identifying microorganisms in a biologic sample are provided. The methods utilize identifying rRNA from microorganisms to both show the presence and identity for the majority of infectious agents present in clinical samples. The methods are preferably adapted for use in a clinical setting.... Agent: Swanson & Bratschun, L.L.C.

20100075329 - Methods for predicting production of activating signals by cross-linked binding proteins: The present invention provides human binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL21R), and uses therefore. The invention further provides methods to predict whether the binding proteins of the invention may take on agonistic activities in vivo and produce a cytokine storm. In... Agent: Fitzpatrick Cella (wyeth LLC)

20100075303 - Methods for targetted mutagenesis in gram-positive bacteria: The present invention provides a method of targeted mutagenesis in Gram-positive bacteria. In particular, the present invention provides a method that effectively integrates a suicide integrative vector into a target gene in the chromosome of a Gram-positive bacterium, resulting in inactivation of the target gene.... Agent: Scully Scott Murphy & Presser PC

20100075334 - Methylation biomarker for early detection of gastric cancer: The present application describes a method of diagnosing gastric cancer or a stage in the progression of the cancer in a subject comprising assaying for loss of expression of a marker gene such as POPDC3, CCDC67, LRRC3B, PRKD1, CYP1B1, LIMS2, DCBLD2, LOC149351, ADCY8, BACH2, ALOX5, TCF4, CXXC4, CAMK2N2, EMX1, KCNK9,... Agent: Jhk Law

20100075315 - Microvesicle-based compositions and methods: Methods and compositions for diagnosis and/or analysis of a condition in a mammal are disclosed in which RNA from microvesicles is enriched and differentiated to so obtain a result that is indicative of the condition of tissue or organ from which the microvesicle originated. In especially preferred embodiments, the condition... Agent: Fish & Associates, PC Robert D. Fish

20100075323 - Molecular markers for lung and colorectal carcinomas: Molecular markers for lung and colorectal carcinomas and methods of using them in blood sample assays are disclosed. The method comprises measuring the expression of the markers in a blood sample from a subject for detecting the presence and/or severity of lung and/or colorectal cancer, and for monitoring and/or assessing... Agent: Ipc Intellectual Property Connections, Inc.

20100075320 - Paxillin mutations, methods of assessing risk of metastasis and methods of staging tumors: Disclosed herein are methods for assessing risk of metastasis of a tumor in a mammal by determining the paxillin gene copy number per cell in the tumor or by detecting the presence of a paxillin mutation in the tumor. The presence of an increased paxillin gene copy number or a... Agent: Michael Best & Friedrich LLP

20100075308 - Polymorphisms in genes affecting cns disorders and uses thereof: Diagnostic and prognostic methods, compositions, assays, and kits useful for predicting the phenotype of subjects who have, or are at risk of developing, a mental disorder. The methods also include predicting the prognostic outcome of a subject's mental disorder as well as the subject's responsiveness to drug treatments for the... Agent: Calfee Halter & Griswold, LLP

20100075304 - Process for monitoring colorectal cancer: Disclosed in this specification is a method for determining the stage of colorectal cancer by observing regulatory changes in select miRNA sequences. These sequences may include hsa-miR-31, hsa-miR-7, hsa-miR-99b, hsa-miR-378*, hsa-miR-133a, hsa-miR-125a and combinations of these sequences.... Agent: Philip S. Johnson Johnson & Johnson

20100075324 - Processes for detecting toxic substances: Biology-based processes for detecting toxic substances are provided. The processes comprise detecting mRNA that is expressed in the presence of toxic substances by a cell comprising a yeast gene as followed, or a gene that is homologous to the yeast genes and is derived from other species, wherein the mRNA... Agent: Birch Stewart Kolasch & Birch

20100075312 - Qpcr analysis apparatus: An apparatus (1) is for DNA amplification with quantitative measurements. A biological sample is held in a cell (2) for the amplification, the cell (2) defining a single space within which the sample rotates. On one side a copper heater (3) is located to supply heat to the cell (2),... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100075336 - System for performing multi-formatted assays: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100075326 - Yeast surface two-hybrid system for quantitative detection of protein-protein interactions: The present invention provides methods and related vectors and host cells for quantitative analysis of protein interactions in eukaryotic expression system. More specifically, the invention provides a yeast surface two-hybrid (YS2H) system that can express a pair of proteins, one protein (“bait”) as a fusion to a yeast cell wall... Agent: Scully Scott Murphy & Presser, PC

20100075340 - Electrical detection of biomarkers using bioactivated microfluidic channels: The present disclosure encompasses the manufacture and use of rapid and inexpensive electrical biosensors comprising microelectrodes in a micro-channel. The devices of the disclosure can be used to detect and quantify target cells, protein biomarkers, and nucleic acid biomarkers, and the like, by measuring instantaneous changes in ionic impedance. The... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100075337 - Method of identification of cells that show sensitivity to modulation of signalingh mediated by fibroblast growth factor receptor or a variant thereof: The invention is based on the finding that cells that show (especially tyrosine) phosphorylation of FGF-R substrate 2 (FRS-2), in contrast to cells that lack such phosphorylation, allow a prediction that treatment with a modulator, especially an inhibitor, of Fibroblast Growth Factor-Receptor signaling will be successful in cells e.g. from... Agent: Novartis Institutes For Biomedical Research, Inc.

20100075339 - Surface-enhanced raman scattering (sers) based nanoparticle composites: Nanoparticle composites and method of use thereof for simultaneously sensing and probing a biological system, comprising providing a nanoparticle composite comprising a nanoparticle comprising a core and a shell; a first ligand bound to the nanoparticle, said first ligand capable of sensing pH; a second ligand bound to the nanoparticle,... Agent: Los Alamos National Security, LLC

20100075338 - Whole blood assay: A method and apparatus to estimate the concentration of a target substance (e.g. Cholesterol or CRP) in the plasma component of awhole blood sample without the need to separate the red blood cells from the plasma prior to testing, thereby simplfying the design and construction of the test device. The... Agent: Fox Rothschild LLP

20100075341 - Standardized evaluation of therapeutic efficacy based on cellular biomarkers: The present invention provides materials and methods for predicting the response of a disease state to a therapeutic agent. A targeting moiety specific for a biological marker is labeled with a reporter moiety and used to analyze cells characteristic of the disease state. The output of the reporter moiety, which... Agent: Wilson, Sonsini, Goodrich & Rosati

20100075343 - Novel peptides: The present invention provides novel peptides with energy-modulating activity or circulatory function-modulating activity. The peptides of the present invention have energy-modulating activity or circulatory function-modulating activity and thus are useful for treating food consumption disorders and diseases of the circulatory system.... Agent: Townsend And Townsend And Crew, LLP

20100075345 - Method of screening: A method of screening for a molecule which decreases apoptosis of a cell, comprising: i) combining the candidate molecule and an assay cell; and ii) determining the change in survival of the assay cell in the presence of the molecule relative to a control. In one embodiment, the assay cell... Agent: Klauber & Jackson

20100075344 - Methods, assays and kits for cancer diagnosis and screening utilizing glycan-binding and glycan epitopes: The invention relates to the diagnosis, monitoring, prognosis, and/or prediction of cancer utilizing the detection or measurement of glycan-protein interactions, particularly glycan-antibody interactions. The invention relates to carbohydrate-containing molecules that are utilized in bioanalytical systems, methods and kits for detecting neoplasia and methods related thereto and based thereon. In an... Agent: Klauber & Jackson

20100075346 - Fret protease assays for clostridial toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Allergan, Inc.

20100075347 - Methods of detection using acousto-mechanical detection systems: Methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). The detection... Agent: 3m Innovative Properties Company

20100075342 - Biomarker for ovarian cancer ctap3-related proteins: The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarker can be detected by SELDI mass spectrometry.... Agent: Edwards Angell Palmer & Dodge LLP

20100075348 - Method for diagnosis of a disease involving an anti-endothelin-receptor antibody: The invention relates to a method for diagnosis of a disease, wherein presence or absence of an anti-endothelin-receptor antibody is determined in a sample from a patient to be diagnosed more in particular an anti-endothelin-receptor-A antibody. The disease according to the invention is in particular selected from diabetes, preferably type... Agent: Millen, White, Zelano & Branigan, P.C.

20100075349 - Rapid elisa processes and related compositions: The present invention provides improved and rapid detection methods for an antigen such as a chemical compound, a peptide, a nucleic acid, or a protein released from cells or virus particles in situ. The detection time for an antigen can be dramatically reduced relative to conventional technologies. The technology can... Agent: Eckert Seamans Cherin & Mellott

20100075350 - Adp detection based luminescent phosphotransferase or atp hydrolase assay: The invention provides compositions and methods to determine or detect the activity of enzymes, including phosphotransferases such as kinases (e.g., protein, lipid, and sugar kinases) and ATP hydrolases such as ATPases, e.g., HSP90, that employ ATP as a substrate and form ADP as a product by monitoring changes in ADP.... Agent: Michael Best & Friedrich LLP

20100075351 - Bioluminescent detection of cyanohydroxy benzothiazole compounds: The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. Also provided are novel compounds that can be used in the methods. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules,... Agent: Michael Best & Friedrich LLP

20100075353 - Method and glucose monitoring system for monitoring individual metabolic response: A system and a method for monitoring individual metabolic responses and generating nutritional feedback based on the monitored responses in a qualified subject are disclosed. Measurements of glucose level in the subject are consecutively performed by a measuring device to generate corresponding first data. Subsequently, data is transmitted to an... Agent: Dinsmore & Shohl, LLP Fifth Third Center

20100075352 - Method of assaying bolld component by using whole blood and measurement kit: [Means For Solving Problems] A method of assaying a blood component to be used for assaying a blood component interfered by glucose and/or its derivative, characterized by comprising bringing the whole blood into contact with a substance capable of converting glucose and/or its derivative into another substance not interfering the... Agent: Nields, Lemack & Frame, LLC

20100075354 - Marker for identification of tissue type of epithelial ovarian cancer, and method for determination of the occurrence of epithelial ovarian cancer based on tissue type by using the marker: It is provided a method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type in view of molecular typing which is different from a conventional histopathology, and a marker for identification of a tissue-type of epithelial ovarian cancer. A method for identification of the morbidity of... Agent: Cheng Law Group, PLLC

20100075356 - Analysis of proteolytic processing by mass spectrometry: The present invention relates to the simultaneous analysis of samples for determining differential proteolytic processing based on isotopic labelling of N-terminal peptides, wherein the isotopic labelling is achieved by incorporation of 18O during enzymatic proteolysis.... Agent: Philips Intellectual Property & Standards

20100075357 - Fret protease assays for clostridial toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Allergan, Inc.

20100075355 - Ultra-sensitive detection of enzymes by capture-and-release followed by quantification: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules... Agent: Wolf Greenfield & Sacks, P.C.

20100075358 - Fret protease assays for clostridial toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Allergan, Inc.

20100075359 - Analyte detection: The present invention relates to analyte detection test systems, including test systems for the oral detection of analytes in saliva. The present invention also provides compositions and methods for storing multiple assay tests and compositions and methods for measuring the concentration of analytes in a sample.... Agent: Casimir Jones, S.c.

20100075362 - Device and method for growing and analyzing cells: A device and method for analyzing cells includes a housing with a chamber, a barrier supported by a frame disposed within the chamber, and a plate arranged at a bottom surface of the housing interior of the chamber. The plate is adapted to receive and sustain cells and the barrier... Agent: Kenyon & Kenyon LLP

20100075367 - Lung cancer detection by optical analysis of body fluids: The method for lung cancer detection by optical analysis of body fluids relates to analyzing samples of blood, urine and sputum by fluorescence spectroscopy in order to detect the presence of naturally occurring molecules in the fluids that serve as biomarkers indicative of cancer in the human body. The analysis... Agent: Litman Law Offices, Ltd.

20100075364 - Method for selecting mammal transformed cells: It is an object of the present invention to provide a method for objectively selecting transformed mammalian cells from a state in which normal mammalian cells coexist with the transformed mammalian cells. The present invention provides a method for selecting transformed mammalian cells, which comprises treating a cell mixture comprising... Agent: Greenblum & Bernstein, P.L.C

20100075366 - Methods for identifying stem cells by detecting fluorescence of cells and syncytia: Methods are disclosed for the characterization of the stage of development or pathology of a tissue sample, and for identifying pluripotent metakaryotic stem cells, comprising detecting fluorescence of cells and syncytia in fixed samples treated with a non-fluorescent Schiff's base reagent in the absence of extraneous or exogenously added fluorescent... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100075361 - Methods of generating florescence resonance energy transfer (fret) between semiconductor quantum dots and fluorescent dyes/proteins via multi-photon excitation, achieving zero background or direct excitation contributions to the fret signature: A system and method of sensing physiological conditions in biological applications includes a laser source for optically exciting a plurality of luminescent quantum dots and a plurality of biomolecules in a nanoscale sensing system having a nanocrystal structure, where the plurality of biomolecules is stained with dye. In a multi-photon... Agent: Naval Research Laboratory Associate Counsel (patents)

20100075365 - Perinucleolar compartment as a cancer marker: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.... Agent: Casimir Jones, S.c.

20100075363 - Recombinant yeast strains expressing tethered cellulase enzymes: Recombinant yeast strains that saccharify, ferment and grow on insoluble and crystalline forms of cellulose are disclosed herein. The yeast strains express tethered cellulases including cellobiohydrolase, endoglucanase and β-glucosidase. The recombinant organisms are particularly suited for consolidated bioprocessing.... Agent: Lathrop & Gage LLP

20100075360 - Uv based cell viability as an indicator of sun protection factor and methods of measurement thereof: Disclosed is a simple method of determining SPF based on the staining pattern of viable cells like mouse fibroblasts and human keratinocytes after exposure to ultraviolet radiations. The method provides results comparable to the standard methods of SPF measurement using human subjects.... Agent: Sabinsa Corporation

20100075368 - Media for recovery of microorganism in the presence of antibiotics: The present invention provides a media and a method of using such as media for the bioburden or sterility testing of antibiotics or environmental testing of antibiotic manufacturing areas. The medium contains one or more divalent or trivalent cation constituents, preferably of magnesium, calcium, aluminum and iron that allow for... Agent: Millipore Corporation

20100075369 - Analyzing reticulocytes: Methods, systems, and computer program products for the analysis of particle analyzer data are disclosed. One embodiment is a method of analyzing immature reticulocytes in a blood sample, including the steps of: preprocessing the blood sample; measuring the blood sample by a detection including a reticulocyte-maturity measurement and a light... Agent: Sterne Kessler Goldstein & Fox, P.l.l.c.

20100075371 - Method and apparatus for detecting and quantifying bacterial spores on a surface: A method and an apparatus for detecting and quantifying bacterial spores on a surface. In accordance with the method: a matrix including lanthanide ions is provided on the surface containing the bacterial spores; functionalized aromatic molecules are released from the bacterial spores on the surface; a complex of the lanthanide... Agent: Steinfl & Bruno

20100075370 - Method for determination of cell viability by using flow cytometry with fixed volume acquisition: The present invention provides a method for comparing the content of a specific cell subpopulation in cell suspension samples by determining the count of cells of said subpopulation per unit volume in each sample, using a flow cytometer with fixed volume acquisition, but without the use of an internal or... Agent: Briscoe, Kurt G. Norris Mclaughlin & Marcus, Pa

20100075372 - Method for deparaffinization of paraffin-embedded specimen and method for analysis of paraffin-embedded specimen: The present invention provides a method for deparaffinization useful for mass spectrometric imaging from a paraffin-embedded specimen. A method for deparaffinization of paraffin-embedded specimen comprising the steps of: exposing a biological sample by subjecting a specimen in which the biological sample is embedded in paraffin, to an organic solvent that... Agent: Cheng Law Group, PLLC

20100075373 - Multi-spectral imaging including at least one common stain: A method including: providing a sample with M components to be labeled, where M>2; labeling the components with N stains, where N<M so that at least two components are labeled with a common stain; obtaining a set of spectral images of the sample; classifying different parts of the sample into... Agent: Fish & Richardson PC

20100075374 - Methods for capturing nascent proteins: Methods of generating and capturing nascent proteins are described, including capturing nascent proteins on the same bead that comprises nucleic acid encoding the protein. The protein or nucleic acid can be sequenced before or after phototransfer to another surface.... Agent: Medlen & Carroll, LLP

20100075375 - Methods for the purification of polypeptide conjugates: The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an... Agent: Leydig Voit & Mayer, Ltd

20100075376 - Dnase expression in recombinant host cells: The present invention relates to cells producing at least one polypeptide of interest and expressing one or more recombinant nuclease encoding gene(s) thereby producing the nuclease(s), and methods for producing a polypeptide of interest essentially free from contaminating DNA, said method comprising the steps of: (a) cultivating a cell that... Agent: Novozymes North America, Inc.

20100075378 - Moraxella catarrhalis basb115 polypeptides: The invention provides BASB115 polypeptides and polynucleotides encoding BASB115 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.... Agent: Seed Intellectual Property Law Group PLLC

20100075377 - Tetramerizing polypeptides and methods of use: The present invention relates to a method of preparing a tetrameric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a vasodialator-stimulated phosphoprotein (VASP) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion... Agent: Zymogenetics, Inc. Intellectual Property Department

20100075379 - Method for making polyalkylene oxide modified hemoglobin: The present invention is a method for preparing a hemoglobin based oxygen carrier to deliver oxygen to tissue. The method comprises mixing a deoxygenated hemoglobin with a maleimide-activated polyakylene oxide (PAO) to obtain an oxygen carrying product. This product is characterized as having 2 to about 8 PAO moieties covalently... Agent: The Nath Law Group

20100075380 - Novel lipase: The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus Tetrasphaera, as well as a gene encoding the same. This lipase has the ability to recognize a medium-chain fatty acid as a substrate. The present... Agent: Drinker Biddle & Reath (dc)

20100075381 - Method for producing glucuronic acid by glucuronic acid fermentation: The object of the present invention is to provide a microorganism having an excellent ability to specifically oxidize the hydroxymethyl group of glucose, and a method of producing glucuronic acid and/or glucuronolactone by using such a microorganism to directly oxidize glucose, and the invention is directed at a microorganism which... Agent: Suzannah K. Sundby Smith, Gambrell & Russel, LLP

20100075383 - Methods for amplifying polymeric nucleic acids: The invention provides compositions and methods for amplifying nucleic acid polymer sequences in a high complexity nucleic acid sample. The unique compositions of the invention include a primer set composed of a mixture of two types of primers for DNA synthesis. For extension in one direction, the primers all contain... Agent: Integrated Dna Technologies, Inc. C/o Darby & Darby P.C.

20100075382 - Ssb-polymerase fusion proteins: Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in nucleic acid amplification methods, including the polymerase chain reaction (PCR).... Agent: Life Technologies Corporation C/o Intellevate

20100075384 - Helicase-dependent amplification of circular nucleic acids: A helicase-mediated amplification method for circular DNA templates and target DNA sequences within the templates is provided. The method combines a DNA polymerase and a helicase preparation to amplify a target sequence as well as the entire circular DNA template.... Agent: Harriet M. Strimpel, D. Phil.

20100075385 - O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in papaver somniferum: The present invention relates to methyl transfer enzymes involved in alkaloid biosynthesis in opium poppy. More particularly, the invention relates to proteins having (R,S)-reticuline 7-O-methyltransferase activity, to proteins having (R,S)-norcoclaurine 6-O-methyltransferase activity and to derivatives and analogues of these proteins. The invention also relates to nucleic acid molecules encoding the... Agent: Thompson Coburn LLP

20100075387 - Delta-9 elongases and their use in making polyunsaturated fatty acids: The present invention relates to Δ9 elongases, which have the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ9 elongase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ9 elongases in... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100075386 - Mutant delta-5 desaturases and their use in making polyunsaturated fatty acids: The present invention relates to mutant Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid [DGLA; 20:3 ω-6] to arachidonic acid [ARA; 20:4 ω-6] and/or eicosatetraenoic acid [ETA; 20:4 ω-3] to eicosapentaenoic acid [EPA; 20:5 ω-3] and which possess at least one mutation within the HPGG motif of the... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100075388 - Plasmid, transformants and process for production of 3- carboxymuconolactone: A recombinant plasmid containing a vanillate demethylase gene (vanAB genes), benzaldehyde dehydrogenase gene (ligV gene) and protocatechuate 3,4-dioxygenase gene (pcaHG genes); transformants incorporating the plasmid; and a process for production of 3-carboxy-cis,cis-muconic acid and/or 3-carboxymuconolactone characterized by culturing the transformants in the presence of vanillin, vanillic acid, protocatechuic acid or... Agent: Locke Lord Bissell & Liddell LLP Attn:IPDocketing

20100075389 - Alkylene oxide capped secondary alcohol ethoxylates as fermentation foam control agents: r

20100075390 - Development and use of an iron-based catalyst for implementing an oxidation-reduction process for substances to be reduced: The invention relates to the use of a ferrous ferric oxyhydroxy salt of the dual lamellar hydroxide family as a catalyst, or as a precursor of the catalyst having the same crystalline structure as the catalyst, for implementing an oxidation-reduction method, the ferrous ferric oxyhydroxy salt being used in association... Agent: Young & Thompson

20100075391 - Composition and method for handling tissue samples: The present invention relates to a composition and method for handling tissue samples for analysis. In particular the present invention relates to a composition and method for orientating tissue for histological and/or pathological laboratory analysis.... Agent: Knobbe Martens Olson & Bear LLP

20100075392 - Method for removing organic solvent: An object of the present invention is to provide a method for efficiently removing a residual organic solvent in a biopolymer structure. The present invention provides a method for removing an organic solvent contained in a biopolymer structure from the structure, (1) wherein the structure is placed in an atmosphere... Agent: Sughrue Mion, PLLC

20100075393 - Aqueous microfabrication of functional bioelectronic architectures: The present invention is an apparatus, system and method for forming nanoscale architectures having nanoparticles bound thereto. The present invention provides a photon beam crosslinked polymer matrix, wherein the crosslinked matrix includes one or more polymers crosslinked to one or more crosslinking agents and one or more protein-coated metal nanoparticles.... Agent: Chalker Flores, LLP

20100075394 - Method of crosslinking two objects of interest: The invention provides a method of crosslinking two objects of interest, comprising the steps of: i) providing a fusion protein comprising at least a first protein and a second protein, wherein both the first and the second protein are, based on their structure and function, capable of forming a covalent... Agent: Harriet M. Strimpel, D. Phil.

20100075395 - Microbial process for production of enzymes: The present invention relates to a suspension culture process for producing an enzyme, comprising the steps of providing a minimal medium, which contains deionised water, mineral salts and an organic carbon source, in a vessel; inoculating the minimal medium with a fungus; incubating the minimal medium at a pH value... Agent: Patent Correspondence Arnall Golden Gregory LLP

20100075396 - Botulinum neurotoxin serotype b activatable botulinum neurotoxin serotype bs: The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located in the di-chain loop region; and method of producing modified Clostridial toxins comprising Clostridial toxin substrate... Agent: Allergan, Inc.

20100075397 - Divinyl ether synthase gene and protein, and uses thereof: The present invention relates to divinyl ether synthase genes, proteins, and methods of their use. The present invention encompasses both native and recombinant wild-type forms of the synthase, as well as mutants and variant forms, some of which possess altered characteristics relative to the wild-type synthase. The present invention also... Agent: Medlen & Carroll, LLP

20100075398 - Bacteriophage preparations and method of use thereof: Disclosed herein are purified bacteriophage preparations that effectively lyse a plurality of C. perfringens strains. In one embodiment, a purified bacteriophage preparation includes four or more C. perfringens-specific bacteriophage, wherein each bacteriophage has lytic activity against at least five C. perfringens strains. In another embodiment, the purified bacteriophage preparation includes... Agent: Cantor Colburn, LLP

20100075399 - Methods for protein refolding: The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100075400 - Low-cost microbial habitat for water quality enhancement and wave mitigation: A low-cost aquatic structure optimized for water quality enhancement and wave mitigation. The structure is preferably comprised predominantly of recycled polymer scrap or other low-cost, high-surface-area materials, such as jute. The structure may be either buoyant or non-buoyant. Buoyant embodiments of the structure are preferably tip resistant. All embodiments are... Agent: Antoinette M. Tease

20100075401 - Minicircle dna vector preparations and methods of making and using the same: The present invention provides minicircle nucleic acid vector formulations for use in administering to a subject, wherein the minicircle nucleic acid vectors include a polynucleotide of interest, a product hybrid sequence of a unidirectional site-specific recombinase, and are devoid of plasmid backbone bacterial DNA sequences. Also provided are methods of... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20100075402 - Dna coding for polypeptide fusion: A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-β and TPO, linked to a subunit of a natural heterodimeric scaffold. Each coexpressed sequence contains a corresponding... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100075403 - Method for production of dry yeast containing s-adenosyl-l-methionine and having excellent storage stability, product produced by the method, and molded composition of the dry yeast: The present invention relates to a method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, the method containing: adding a cyclodextrin compound to a yeast concentrate obtained from a fungus culture liquid of the yeast; and then drying the concentrate, an SAMe-containing dry... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100075404 - Processes for the digestion of colanic acid: The present disclosure generally relates to processes employing polypeptides having colanic acid-degrading activity. The processes generally involve contacting a biological material with a polypeptide capable of digesting colanic acid. Additional process steps, such as chromatographic separation steps, are also described.... Agent: Bryan Cave LLP

20100075405 - Bioreactor jacket: A bioreactor system (10) is provided for controlling temperature of bioreactor media during processing. The system (10) includes a flexible bag (102) having an inner wall (104) defining an inner volume (105) for holding the cell culture media and an outer wall (106) surrounding at least a portion of the... Agent: Knobbe Martens Olson & Bear LLP

20100075406 - Cell culture apparatus, cell culture system and cell culture method: A cell culture apparatus including: a culture container 11 formed of a soft packing material and having an enclosure part 11-1 in which a culture medium and/or cells being cultured are enclosed is placed; a container table 12 on which the culture container 11 is placed; a roller 13 which... Agent: Kanesaka Berner And Partners LLP

20100075407 - Ultra-sensitive detection of molecules on single molecule arrays: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules... Agent: Wolf Greenfield & Sacks, P.C.

20100075408 - Device for microbiological analysis: The device for the microbiological analysis of a support (41) adapted to contain microorganisms marked by a fluorophore agent comprises illuminating means adapted to illuminate said support (41) comprising two bases (21) on each of which is mounted at least one group of light sources (22), with said sources (22)... Agent: Nields, Lemack & Frame, LLC

20100075409 - Device for microbiological analysis: The device for the microbiological analysis of a support adapted to contain microorganisms marked by a fluorophore agent, said agent being adapted to absorb light energy with an absorption spectrum (53) having a crest (53′) at a predetermined absorption wavelength (λ2) and to release that energy by emitting light with... Agent: Nields, Lemack & Frame, LLC

20100075410 - Reusable tissue biopsy kit with padded cassette: An improved biopsy kit for the collection, storage, transportation, and processing of biopsy tissue samples is disclosed. The disclosed biopsy kit consists of a typical specimen container and an improved tissue cassette with adhesively attached polyvinyl alcohol foam pads on both the base and lid portions. An excised tissue sample... Agent: Matthew P. Davies

20100075411 - Specimen manipulation device for micro manipulation and biopsy in assisted reproduction and in vitro fertilization: A container or dish used for the micro manipulation, micro injection, biopsy and fertilization of oocyte and embryo culture. The dish allows the user to more readily perform procedures used to fertilize oocyte, such as intracytoplasmic sperm injection (ICSI), biopsy embryos and perform additional procedures in used in assisted reproductive... Agent: William W. Jones

20100075412 - T1r taste receptors and genes encoding same: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20100075413 - Improved process for the culturing of cells: The invention relates to a process for the culturing of cells, preferably E1-immortalized HER cells, more preferably PER.C6 cells in a reactor in suspension in a cell culture medium, wherein the cells produce a biological substance, preferably an antibody, wherein at least one cell culture medium component is fed to... Agent: Nixon & Vanderhye, PC

20100075414 - Growth of foreign cells after conditional and selective destruction of fetal host cells: Foreign cells can be grown in fetal non-mammalian hosts for the production of transplant organs and tissues, the development of new therapeutic agents, and the production of biological factors and drugs. Tissue-specific injury to fetal host target cells is carried without substantial injury to the maternal host or foreign cells,... Agent: Banner & Witcoff, Ltd.

20100075415 - Method for reducing protease activity in plant hydrolysate: The present invention provides methods for reducing protease activity in plant hydrolysates that are utilized in cell culture media. The method involves a combination of heating and ultrafiltration to remove proteases present in the hydrolysate prior to the addition of the hydrolysate to the cell culture medium.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20100075416 - Growth factor supplement for stem cell cultures: Disclosed is a growth factor supplement for stem cell culture media, stem cell culture media supplemented with the growth factor supplement, and methods for growing and maintaining stem cells in culture. The invention particularly relates to human stem cells, more particularly human embryonic stem cells, neonatal stem cells, adult stem... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100075417 - Methods and devices for isolating embryonic stem cells: Methods, devices and kits are provided for isolating or enriching multicellular embryonic stem (ES) cell colonies from a mixture of multicellular ES cell colonies and single ES cells present in a cellular suspension, by utilizing a filtration matrix that selectively excludes passage of multicellular ES cell colonies. Isolated or enriched... Agent: Howrey LLP-hn

20100075418 - Method for co-culture of stem cells and feeder cells using polymer membrane: The present invention relates to a method for co-culture of stem cells using feeder cells, more particularly to a method for culturing stem cells by using a membrane having a number of pores to separate stem cells and feeder cells. In the present invention, the culture condition of stem cells... Agent: Knobbe Martens Olson & Bear LLP

20100075419 - Biomaterial, method of constructing the same and use thereof: The present provides a biomaterial composed in part of a porous material having an internal structure that has been completely controlled so as to optimize living tissue infiltration or cell introduction, a method of manufacturing, and uses thereof, including bio-implant materials for artificial bones, artificial joints and artificial tooth roots,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100075420 - Novel gene delivery vectors for human mesenchymal stem cells: Novel gene delivery vector compositions that interact with human mesenchymal stem cells are provided, as well as methods of synthesizing and using such compositions. Such compositions may comprise a plurality of hyaluronic acid hexamers covalently attached to a branched polyethylenimine. Such methods of synthesis may comprise providing a plurality of... Agent: Baker Botts L.l.p

20100075421 - Efficient method for nuclear reprogramming: A method of preparing induced pluripotent stem cells, comprising a nuclear reprogramming step with a nuclear reprogramming factor in the presence of miRNA, wherein said miRNA has a property of providing a higher nuclear reprogramming efficiency in the presence of said miRNA than in the absence thereof.... Agent: Greenblum & Bernstein, P.L.C

20100075423 - Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference: The present invention concerns methods and compositions involving RNase III and polypeptides containing RNase III domains to generate RNA capable of triggering RNA-mediated interference (RNAi) in a cell. In some embodiments, the RNase III is from a prokaryote. RNase III activity will cleave a double-stranded RNA molecule into short RNA... Agent: Life Technologies Corporation C/o Intellevate

20100075422 - Transfection microarrays: e

20100075424 - Methods and compositions for genetically engineering clostridia species: The present invention relates to methods and compositions for engineering Clostridia species. In particular, embodiments of the present invention relate to the expression of recombinant resolvase proteins in Clostridia species.... Agent: Casimir Jones, S.c.

  
03/18/2010 > patent applications in patent subcategories. listing by industry category

20100068690 - Tissue preservation and fixation method: This invention relates, e.g., to a composition that, at room temperature, when contacted with a sample comprising phosphoproteins, can fix and stabilize cellular phosphoproteins, preserve cellular morphology, and allow the sample to be frozen to generate a cryostat frozen section suitable for molecular analysis. The composition comprises (1) a fixative... Agent: The Law Office 0f Geoffrey M. Karny

20100068691 - Tissue system and methods of use: Apparatus and methods of use of a tissue system for culture and perfusion. The apparatus comprises needles for injecting a fluid into the tissue.... Agent: Intellectual Property / Technology Law

20100068692 - Antifreeze glycoprotein analogues and uses thereof: wherein X is nitrogen, sulfur, carbon or (CR1R2)nS═O wherein n is 0, 1, 2 or 3, Y is carbon, nitrogen, sulfur or oxygen, R1 is hydrogen, methyl, fluorine, a carbohydrate, or a hydroxy chain, R2 is hydrogen, methyl, fluorine, a carbohydrate or a hydroxy chain, R3 to R6 independently represent... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20100068693 - Nutrient monitoring and feedback control for increased bioproduct production: The present invention pertains to methods of increasing the efficiency of producing a bioproduct. In some embodiments, the method increases the quantity of a bioproduct produced, or decreases bioproduct production time, in a bioreactor cell culture producing the bioproduct, the method comprising, (a) intermittently or continuously analyzing the concentration of... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20100068695 - Inhibitor for enzyme having two divalent metal ions as active center: e

20100068694 - Method, reagent and kit for malaria testing: The present invention provides a method for malaria testing which enables testing for the presence of malaria infection and the extent of the infection in a convenient manner; and a reagent or kit which can be used in the method. The method for malaria testing according to the present invention... Agent: Knobbe Martens Olson & Bear LLP

20100068697 - Piezoelectric microcantilever sensors for biosensing: A piezoelectric microcantilever for sensing compounds or molecules. The piezoelectric microcantilever, may include at least one electrode, an insulation layer, a receptor, an immobilization layer, a non-piezoelectric layer and a piezoelectric layer The sensor is capable of self actuation and detection. The piezoelectric layer may be constructed from a highly... Agent: Knoble, Yoshida & Dunleavy

20100068698 - Production of infectious hepatitis c virus particles in cell culture: The present invention provides for novel methods of producing high levels of infectious HCV genotype 1 virus particles in cell culture systems. The availability of HCV genotype 1 virus (principally associated with liver disease in most regions of the world) that can undergo the complete viral cycle in cultured cells... Agent: Grant D. Green Patent Law Department, M/s A2-250

20100068696 - Universal biosensor and methods of use: The present invention relates to methods for detecting or quantifying an analyte in a test sample including providing at least one test mixture including a test sample, at least one marker complex, wherein each marker complex includes a particle, a marker, and one member of a coupling group, a first... Agent: Nixon Peabody LLP - Patent Group

20100068699 - Assay system for monitoring the effects of genetically engineered cells to alter function of a synctium: This invention provides methods for determining the ability of a gene construct to alter the rhythm and contractility of a syncytial cell. Furthermore, this invention provides methods for constructing a gene construct capable of altering the rhythm or contractility of a syncytial cell. Finally, this invention provides a method for... Agent: Kenyon & Kenyon LLP

20100068717 - Cancer therapy prognosis: Methods and compositions based on FOXA1 expression to predict long-term disease-free survival in patients with breast cancer are disclosed. In ER+ positive patients, expression of FOXA1 is useful in identifying a subgroup of patients with a better prognosis. FOXA1 expression correlates with luminal subtype breast cancer, and serves as a... Agent: Barnes & Thornburg LLP

20100068719 - Cell culture system for determinging the sensitizing, allergenic and/or irritating effect of a substance: The present invention refers to a cell culture system especially for investigating the sensitizing, allergenic and/or irritating effect of substances, comprising a first and a second compartment that can communicate with each other via a permeable interlayer, whereby the first compartment has an epidermis model and the second a cell... Agent: Foley And Lardner LLP Suite 500

20100068701 - Chromosome labeling method: A method of sample analysis is provided. In certain embodiments, the method may involve a) contacting a genomic sample comprising a test chromosome with a plurality of sets of labeled oligonucleotide probes under in situ hybridization conditions to produce a contacted sample having an oligonucleotide binding pattern; b) imaging the... Agent: Agilent Technologies Inc.

20100068716 - Disposable articles for analysis and diagnostics for a laboratory: The invention relates to disposable articles for a laboratory and in particular to prepared reaction vessels for conducting the polymerase chain reaction for analytical and diagnostic purposes. The invention further relates to a method for the stable storage and drying of minute amounts of oligonucleotides and reference nucleic acids in... Agent: Dickstein Shapiro LLP

20100068703 - Enhanced medical treatments resulting from chemical identification of calcium influx factor, identity with the factor activating phospholipolysis and precipitating sudden death during myocardial infarction, and determination of similar activating mechanis: A method for treating a mammal comprises administering at least one of a gene, enzyme and pharmaceutical which modulates the concentration of iPLA2β through transcriptional and/or translational regulation or effectively modulate the inhibition of iPLA2β through calmodulin or derivatives thereof.... Agent: Patrick W. Rasche Armstrong Teasdale LLP

20100068705 - Genetic susceptibility variants associated with cardiovascular disease: The invention relates to methods of diagnosing susceptibility to cardiovascular disease, including coronary artery disease. MI, abdominal aorta aneurysm, intracranial aneurysm restenosis and peripheral arterial disease, by assessing the presence or absence of alleles of certain polymorphic markers found to be associates with cardiovascular disease. The invention further relates to... Agent: Marshall, Gerstein & Borun LLP

20100068715 - Marker genes for use in the identification of chondrocyte phenotypic stability and in the screening of factors influencing cartilage production: The present invention relates to a set of genes which can be used to predict the potential of a cell population to form cartilage when implanted in vivo. The set of markers is used inter alia as a quality control of cells and in screening assays to evaluate the impact... Agent: Clark & Elbing LLP

20100068720 - Method and kit for detection of early cancer or pre-cancer using blood and body fluids: This invention is related to a method for the detection of early or pre-cancer using DNA isolated from blood and body fluids. This invention provides an improved methylation-based PCR assay, a panel of methylated-based cancer-related gene markers for the detection of general cancer and a panel of unmethylation-based tissue- or... Agent: Weiwei. Li

20100068721 - Method and system for protection and cross protection of algae and cyanobacteria from virus an bacteriophage infections: Virus contaminations of bioreactors can cause considerable losses in the industry and prevention of such contaminations is usually a major concern, especially in continuous cultures and particularly in outdoor/uncovered operations such as ponds or “racing ponds”. Use of transgenic algae/cyanobacteria harboring introgressed virus/phage DNA fragments, cultured in these bioreactors/ponds will... Agent: John Dodds

20100068702 - Method for detecting disease-related marker using gastric mucosal lavage fluid: The invention relates to a sample containing a gastric mucosa lavage fluid collected from a subject who has received a gastric mucus removal treatment and a method for detecting a disease-related marker using the same. By using the sample of the invention, the disease-related marker can be detected conveniently, less... Agent: Wolf Greenfield & Sacks, P.C.

20100068709 - Method for determining a tongue cancer: An object is to provide: a method for determining a tongue cancer in which the malignancy of tongue cancer can be objectively and accurately determined; a method for analyzing a tongue cancer tissue specimen; and a kit for analyzing a tongue cancer tissue specimen. There is provided: a method for... Agent: Darby & Darby P.C.

20100068707 - Method for screening for vitamin d receptor ligands: The present invention relates to a screening method for a compound and includes a step of detecting binding between a vitamin D receptor and CDP. A novel method enabling screening in vitro of a compound having strong bone forming action and low side effects, a compound participating in osteoblast differentiation... Agent: Sughrue Mion, PLLC

20100068706 - Method for separating an analyte from a sample: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge... Agent: Townsend And Townsend And Crew, LLP

20100068718 - Methods and compositions for identifying yeast: The invention relates to a method of identifying a specific yeast species in patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the yeast species from the patient tissue or body fluid, amplifying the DNA, hybridizing a probe to the DNA to specifically... Agent: Barnes & Thornburg LLP

20100068710 - Methods and products for in vitro genotyping: An in vitro method for genotyping genetic variations in an individual, and products for use in the method.... Agent: Wolf Greenfield & Sacks, P.C.

20100068708 - Methods for identifying compounds that modulate wnt signaling in cancer cells: Provided herein are methods for screening compounds for their ability to modulate Wnt signaling in cancer cells.... Agent: Fish & Richardson P.C.

20100068711 - Methods of pcr-based detection of \"ultra short\" nucleic acid sequences: The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100068700 - Methods of using gpr 119 receptor to identify compounds useful for increasing bone mass in an individual: The present invention relates to methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual. Agonists of GPR119 receptor are useful as therapeutic agents for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in... Agent: Fish & Richardson P.C.

20100068723 - Microfluidic devices: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such asDNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.... Agent: Microchip Biotechnologies, Inc.

20100068722 - Modified nucleosides and nucleotides and uses thereof: The invention is directed to modified guanine-containing nucleosides and nucleotides and uses thereof. More specifically, the invention relates to modified fluorescently labelled guanine-containing nucleosides and nucleotides which exhibit enhanced fluorophore intensity by virtue of reduced quenching effects.... Agent: Klauber & Jackson

20100068714 - Multivariate detection of molecules in biossay: The invention relates to detection of target molecules in an assay, such as a bio-assay, and in particular to multi-variate detection of target molecules. A detector system is disclosed, the detection system comprising an optical guide element (16) for directing luminescence radiation (7) from an associated sample towards a multivariate... Agent: Philips Intellectual Property & Standards

20100068704 - Oligonucleotides comprising signalling pairs and hydrophobic nucleotides, stemless beacons, for detection of nucleic acids, methylation status and mutants of nucleic acids: The invention relates to novel oligonucleotides comprising a signalling pair and at least hydrophobic nucleotide. The oligonucleotide analogues are useful for detecting the status of nucleic acid sequences, such as presence, expression, methylation and/or mutation, in particular single point mutations and other sequences where the variation between the correct target... Agent: Brooks Kushman P.C.

20100068712 - Oligonucleotides for use in allele-specific pcr: The present invention relates to oligonucleotides complementary to a target polynucleotide, wherein the oligonucleotide comprises an LNA unit, a mismatch nucleobase, and an allele-specific nucleobase corresponding to an allele of the target polynucleotide. The invention further includes methods of using such oligonucleotides to detect and quantitate the frequency of particular... Agent: Brinks Hofer Gilson & Lione/utah Utah Office

20100068713 - Probe for detecting mutation in jak2 gene and use thereof: A probe for detecting a mutation in the JAK2 gene is provided that can detect a target sequence containing a mutation even when the target sequence containing the mutation and a non-target sequence containing no mutation coexist, which are different only in a single base from each other. The probe... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100068726 - Antigen detection method involving an oligonucleotide enhanced colloidal gold signal: The present invention refers to a rapid immunochromatographic test device for antigen detection, comprising a first and a second conjugate releasing pad, wherein the first conjugate pad comprises a gold conjugated protein linked first oligonucleotide and a gold conjugated antigen specific antibody, and the second conjugate pad comprises a gold... Agent: Patent Central LLC Stephan A. Pendorf

20100068724 - Biomaker for ovarian and endometrial cancer: hepcidin: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status as well as endometrical cancer status in a patient. In particular, it has been found that hepcidin is a biomarker for both ovarian cancer and endometrial cancer and that a panel of biomarkers,... Agent: Edwards Angell Palmer & Dodge LLP

20100068725 - Direct determination of vitamin d in serum or plasma: A method for quantitating vitamin D metabolites directly in blood plasma or serum, without the need for prior purification of the vitamin D metabolites, comprising a digestion of the serum proteins with a serine protease such as proteinase K and sequence of steps for inhibiting the proteinase K activity in... Agent: Dickstein Shapiro LLP

20100068729 - Method and kits for the diagnosis of diabetes: Provided are methods for the detection and diagnosis of a predisposition for developing diabetes. The methods are based on the discovery that abnormal levels of the selected analyte in biological samples, typically blood samples, of patients who are at risk are supportive of a diagnosis of a predisposition for developing... Agent: Foley And Lardner LLP Suite 500

20100068728 - Polysaccharide derivatives and uses in induction of an immune response: The present invention generally provides compositions comprising a polysaccharide derivative, and methods of their preparation and use for the prevention or treatment of diseases caused by Neisseria meningitidis bacteria, particularly group B (NmB) strains, and by E. coli K1. The invention provides a de-N-acetylated PS derivative in which one or... Agent: Bozicevic, Field & Francis LLP

20100068727 - Rapid immunochromatographic detection by amplification of the colloidal gold signal: The present invention relates to a method for rapid immunochromatographic detection of a target in a sample by double sandwich immunoassay detection, wherein the target is an antibody and/or an antigen, using different colloidal gold conjugates conjugated with a first and a second specific antibody or antigen and with at... Agent: Patent Central LLC Stephan A. Pendorf

20100068732 - Cloned glucagon-like peptide-2 receptors: The invention relates to nucleotides and amino acid sequences encoding Glucagon-like peptide-2 receptors, recombinant host cells transformed with such nucleotides, and methods of using the same in drug screening and related applications.... Agent: Stoel Rives LLP - Slc

20100068733 - Ph-sensitive fluorescent probe: wherein R1 represents an amino group which may be substituted with one or two alkyl groups; R2, R3, R4 and R5 independently represent an alkyl group; and R6 and R7 independently represent a monocarboxyalkyl group, a salt thereof, or an ester thereof, which is useful as a pH-sensitive fluorescent probe... Agent: Greenblum & Bernstein, P.L.C

20100068731 - Use of n-myristoyltransferase on non-tumor tissue for cancer diagnosis: A diagnostic method and kit are disclosed for detection of cancer. Detection of elevated levels of N-myristoyltransferase (NMT) or NMT activity in blood or bone marrow, and specifically in peripheral blood mononuclear cells, can be used as a marker for cancer. The use of this method for detection of adenocarcinoma,... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100068734 - Nanoparticle and microparticle based detection of cellular products: Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic spectral feature. In particular, devices and methods are provided for measuring secreted cellular products including cytokines. Detection substrates, include microwells having product-specific capture reagents thereon... Agent: Borson Law Group, PC

20100068730 - Method for screening anti-cancer compounds inhibiting function of tm4sf5 and anti-cancer composition containing chalcone compounds: The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as... Agent: Nixon Peabody LLP - Patent Group

20100068737 - Enzyme-linked immunosorbent assay (elisa) for canine hepcidin: The present invention relates to the use of hepcidin-specific antibodies for the detection of hepcidin in biological samples for the diagnosis of diseases and disorders related to iron metabolism. Kits useful in screening various subjects suspected of having diseases or disorders associated with iron metabolism are also provided.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100068735 - Microfluidic device including unit for evaluating capture material and method of evaluating capture material: Provided are a microfluidic device including a unit for evaluating a capture material and a method of evaluating a capture material.... Agent: Sughrue Mion, PLLC

20100068736 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer: Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100068738 - Method of immunoassaying a component to be measured: A method of immunoassaying a component to be measured in a sample containing hemoglobin, which comprises reacting a component to be measured in a sample containing hemoglobin with an antibody capable of binding to the component in the presence of a bile acid derivative different from a bile acid derivative... Agent: Fitzpatrick Cella Harper & Scinto

20100068739 - Ph tolerant luciferase: Use of a luciferase that has a mutation of at least one amino acid selected from the group consisting of positions 14, 35, 182, 232 and 465, where the numbering is according to the sequence of the luciferase from P. pyralis (SEQ ID NO:1) in a method that is performed... Agent: Nixon & Vanderhye, PC

20100068740 - Microfluidic device with a cylindrical microchannel and a method for fabricating same: A method of manufacturing a microfluidic device having at least one cylindrical microchannel includes providing a substrate, casting an uncured polymer matrix solution onto the substrate, embedding an elongated rod in the uncured polymer matrix solution, curing the polymer matrix solution to form a solidified body, and extracting the elongated... Agent: David S. Resnick

20100068741 - Assay system for adenosine triphosphate and creatine kinase: An assay method includes providing a luminescent nanocrystal; combining a solution having an adenosine triphosphate molecule; and displaying a light emission by the luminescent nanocrystal and the solution combined.... Agent: Law Offices Of Mikio Ishimaru

20100068743 - Method for predicting response of cancer patient to anticancer drug treatment: A method predicts a response of a cancer patient to anticancer drug based on a cell cycle profile score obtained by analyzing a malignant tumor of the cancer patient, wherein the method can predict a disease outcome including a complete response, a partial response, stable disease, no response, and time... Agent: Brinks Hofer Gilson & Lione

20100068742 - Methods: A method for identifying a compound expected to be useful in modulating, for example inhibiting, LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates, for example inhibits, the protein kinase activity of a LRRK2 polypeptide on a substrate polypeptide and (2) selecting... Agent: K&l Gates LLP

20100068744 - Method for the purification of heat shock proteins: Recombinant purified DnaK—having a ATPase activity without the addition of an other chaperone protein—essentially free of T-cell stimulating impurities.... Agent: Dardi & Herbert, PLLC

20100068745 - Process and kit for measuring the condition of the fibrinolitic system: The invention relates to an assay and a kit for the determination of the status of the fibrinolytic system. In particular the invention relates to a method for the determination of the status of the fibrinolytic system from tear fluid samples. Additionally the invention relates to a sterilized, calibrated capillary... Agent: Ladas & Parry LLP

20100068746 - Diagnosis method for fatty liver disease, diagnosis apparatus, diagnosis program, diagnostic agent, and method for screening for therapeutic agent for fatty liver disease: There is provided an examination method which is simpler than conventional liver biopsy and enables the diagnosis of steatohepatitis. This diagnostic method comprises the steps of measuring the concentration of choline contained in a blood-derived sample collected from a subject; and determining the presence of fatty liver disease, severity of... Agent: Birch Stewart Kolasch & Birch

20100068748 - Fluorescent ion indicators for cadmium and lanthanide ion detection: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of heavy metal ions in a sample. This metal chelating moiety has the following formula... Agent: Life Technologies Corporation C/o Intellevate

20100068747 - Generic assay for monitoring endocytosis: A method for monitoring the internalisation of a cell surface molecule of interest is provided utilizing a detectable lectin.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100068751 - Method and system for artifact reduction: A method is presented for obtaining characteristics of a target physical entity by providing an excitation signal to the target physical entity and simultaneously measuring the response of the target physical entity. Analog signal processing is performed on the measured response to eliminate artifacts arising from a signal path outside... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100068750 - Method for fluorometrically determining photosynthesis parameters of photoautotropic organisms, device for carrying out said method and a measurement chamber: The invention can be used in biology and for environmental studies using fluorimeters. The inventive method consists in producing exiting light pulses having equal amplitude and modifiable duration, in measuring fluorescent chlorophyll characteristics at a constant background illumination simulating the irradiation intensity of an object during studies in the natural... Agent: Ladas & Parry LLP

20100068752 - Novel fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest: The present invention provides dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides... Agent: Enzo Biochem, Inc.

20100068749 - Optical sensor and method for indicating the age or quality of a natural product: The present invention relates to the field of analyzing the age and/or quality of certain natural products, for example foods. The invention also relates to devices for analyzing said age and/or quality as well as to methods for preparing such devices, to methods for analyzing natural products and to their... Agent: K&l Gates LLP

20100068753 - Biotin-facilitated transport in gram negative bacteria: Biotinylation of compounds such as peptides and peptidomimetics facilitates illicit transport of the compounds into Gram negative bacteria.... Agent: Mueting, Raasch & Gebhardt, P.A.

20100068754 - Density-based cell detection system: The invention provides a low-cost method for identifying and/or measuring a subpopulation of cells in a biological sample, such as a subpopulation of CD4-positive cells in a whole blood sample. In accordance with the invention, one or more cell surface markers are identified on a subpopulation of interest, which collectively... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100068756 - Method and apparatus for detecting and quantifying bacterial spores on a surface: A method and an apparatus for detecting and quantifying bacterial spores on a surface. In accordance with the method: bacterial spores are transferred from a place of origin to a test surface, the test surface comprises lanthanide ions. Aromatic molecules are released from the bacterial spores; a complex of the... Agent: Steinfl & Bruno

20100068755 - Method and system for detection and/or characterization of a biological particle in a sample: The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample whereby the method may be accomplished non-invasively by utilizing a time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and... Agent: Biomerieux, Inc.

20100068757 - In situ heat induced antigen recovery and staining apparatus and method: An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually... Agent: Dunlap Codding, P.C.

20100068761 - Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains: The present invention relates to a polynucleotide encoding an omega 3 (ω-3) desaturase from Pythium irregulare with specificity to long chain polyunsaturated omega 6 (ω-6) fatty acids as well as a vector containing said polynucleotide, and a host cell containing the vector or the polynucleotide. Moreover, the present invention pertains... Agent: Connolly Bove Lodge & Hutz, LLP

20100068763 - Mammalian chemokines; receptors; reagents; uses: Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are disclosed. Methods of using the chemokines, receptors, reagents and diagnostic kits are also provided.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20100068759 - Modified chondroitin synthase polypeptide and crystal thereof: Disclosed are: (A) a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, or (B) a polypeptide comprising an amino acid sequence of SEQ ID NO:2 including deletion, substitution or addition of one or several amino acid residues and having chondroitin synthase activity; a nucleic acid encoding the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100068758 - Mutant arabinose promoter for inducible gene expression: An L-arabinose inducible expression system comprising a mutant arabinose promoter. This system exhibits an increase in heterologous protein production upon induction with L-arabinose and comprises a mutant araB promoter and an AraC transcription binding region. This system retains the tight regulatory control characteristic of the wild type arabinose operon.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100068762 - Novel nucleic acid molecules: The present invention relates to a novel nucleic acid molecule encoding an amino acid sequence, which is capable of forming a cyclic structure. Cyclization may occur within a cell or cell membrane, or linear forms of the molecules may be circularised or partially circularised, in vitro using isolated enzyme systems... Agent: Casimir Jones, S.c.

20100068760 - Proteins with esterase activity: The invention relates to novel proteins having esterase activity, to mutants thereof, to nucleic acid sequences coding therefor, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.... Agent: Connolly Bove Lodge & Hutz, LLP

20100068764 - Droplet actuator devices and methods employing magnetic beads: A method of providing a droplet in contact with a magnetically responsive bead and having a reduced quantity of a substance. The method generally includes the steps of (a) providing a droplet actuator (200) comprising: (i) a substrate (210) comprising electrodes (214) arranged for conducting droplet operations on a surface;... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20100068765 - Systems and methods for the amplification of dna: A system for amplifying nucleic acids is disclosed which, in one embodiment, includes a fluidic device having a sample channel and a heat exchange channel disposed sufficiently close to the sample channel such that a heat exchange fluid in the heat exchange channel can cause a sample in the sample... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100068766 - Composition for cleaving and/or connecting single strand dna: It is an object of the present invention to provide a composition for catalyzing the cleavage of a single-stranded DNA and the binding of such single-stranded DNA. The present invention provides a composition for cleaving a single-stranded DNA and/or binding the 5′-terminus of such single-stranded DNA to the 3′-terminus thereof,... Agent: Pearne & Gordon LLP

20100068767 - Multi-component inhibitors of nucleic acid polymerases: The present invention provides multi-component inhibitors of nucleic acid polymerases, methods of making, and methods of using same. One component of the multi-component inhibitor is a molecule that binds to a polymerase (i.e., a polymerase-binding molecule (PBM)), but does not thereby substantially inhibit its polymerase activity. Another component is a... Agent: Life Technologies Corporation C/o Intellevate

20100068768 - Enzyme compositions and methods for the improved enzymatic hydrolysis of cellulose: A process for the enzymatic hydrolysis of cellulose to produce a hydrolysis product comprising glucose from a pretreated lignocellulosic feedstock and enzymes for use in the process are provided. The process comprises partially hydrolyzing an aqueous slurry of a pretreated lignocellulosic feedstock with cellulase enzymes, one or more than one... Agent: Fitzpatrick Cella Harper & Scinto

20100068769 - L-glutamic acid-producing microorganism and a method for producing l-glutamic acid: A coryneform bacterium that is modified by using a yggB gene so that L-glutamic acid-producing ability is enhanced as compared to a non-modified strains is cultured in a medium to cause accumulation of L-glutamic acid in the medium or bacterial cells, and L-glutamic acid is collected from the medium or... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100068770 - Method for the chemo-selective enzymatic hydrolysis if a diester compound for preparing a monoester monoacid compound: c

20100068771 - Process for the preparation of enantiomerically enriched beta-amino alcolhols starting from glycine and an aldehyde in the presence of a threonine aldolase and a decarboxylase: The invention relates to a process for the preparation of an enantiomerically enriched β-amino alcohol, wherein glycine or a glycine salt and an aldehyde are reacted in the presence of a threonine aldolase and a decarboxylase to form the corresponding enantiomerically enriched β-aminoalcohol, and wherein at least either the threonine... Agent: Nixon & Vanderhye, PC

20100068772 - Solubilization of algae and algal materials: Methods for solubilizing algae or algal material are provided to facilitate the recovery of oil or lipids, as well as hydrocarbons and carbohydrates, from algae or algal material. The methods involve contacting algae or algal material with an oxoacid ester or thioacid ester of phosphorus or a mixture of an... Agent: Alan J. Grant, Esq. C/o Carella, Byrne, Bain,

20100068773 - Microbiological production of 3-hydroxyisobutyric acid: The present invention relates to a cell which has been modified in comparison with its wild type in such a way that it is capable of forming more, by comparison with its wild, 3-hydroxyisobutyric acid or poly-hydroxyalkanoates based on 3-hydroxyisobutyric acid via methylmalonate-semialdehyde or 3-hydroxybutyryl-coenzyme A as precursors. The invention... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100068774 - Method for producing an organic acid: An organic acid is produced by allowing a bacterium which has an ability to produce an organic acid and has been modified so that expression of the sucE1 and mdh genes are enhanced, or a product obtained by processing the bacterium, to act on an organic raw material in a... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100068775 - Novel genes for the fermentative production of hydroxytyrosol: The present invention relates to the use of polynucleotides and polypeptides as biotechnological tools in the production of hydroxytyrosol from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of hydroxytyrosol in said microorganism. The invention... Agent: Nixon & Vanderhye, PC

20100068776 - Genetically modified cyanobacteria for the production of ethanol: The invention provides novel compositions of matter for the production of ethanol from carbon dioxide and water. Particularly, the invention provides photoautotrophic organisms having a first and second genetic modification, wherein the first genetic modification improves the ethanol production from organisms having the second genetic modification.... Agent: Algenol Biofuels, Inc.

20100068777 - Methods for producing biofuels and compositions for use in biofuel production methods: Beneficial virus, such as phage, is used in fermentation methods and other techniques for producing biofuels. The beneficial virus (e.g., phage) may be targeted toward microorganisms (e.g., bacteria, etc.) that undesirably affect the fermentation or biofuel production process. Beneficial virus targeted toward microorganisms that undesirably affect the product or by-product... Agent: Traskbritt, P.C.

20100068778 - Process for comprehensively utilizing steam exploded radix puerariae and device therefor: The invention provides a process for co-producing ethanol and Radix Puerariae flavones and utilizing Radix Puerariae fibers from Radix Puerariae by way of clean solid state fermentation, and the device used therein. The process comprises the following steps: providing Radix Puerariae as raw material; pretreating the Radix Puerariae raw material... Agent: Knobbe Martens Olson & Bear LLP

20100068779 - Algaculture system for biofuel production & methods of production thereof: Embodiments of algaculture systems to generate biofuel are herein provided. In one embodiment, an algaculture system includes a photo-bioreactor (PBR) including pump/tank assembly in communication with an input portion of a solar collector. The pump/tank assembly may act as a reservoir and/or agitator for a mixture of algae, water and... Agent: Loza & Loza LLP

20100068780 - Method for the selection and/or the processing of particles, in particular cells: Method for the selection or the processing of first particles sensitive to the application of an external stimulus including the step of producing, through the application of the external stimulus, the permeabilization of at least a selected first particle, consisting in the organization of the first particles through a first... Agent: Venable LLP

20100068781 - Mechanical lysis arrangements and methods: Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is... Agent: Steinfl & Bruno

20100068782 - Method for the surface treatment of solid substrates: The invention relates to a process for the chemical modification of a surface of a support, in which said surface contains available hydroxyl groups and lacks metals or metallic alloys. According to the invention, the surface is treated with orthophosphoric acid. The surface thus treated can be used to immobilize... Agent: Moore & Van Allen PLLC

20100068783 - Tailored control of surface properties by chemical modification: A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the following formula (1): whose substituent groups are SP defined herein, provided that when R is aryl or heteroaryl, said aryl or... Agent: Nixon & Vanderhye, PC

20100068784 - Process for immobilization of protein catalysts, product, and use: An immobilized protein catalyst is prepared by applying an adhesive to a polymeric support, applying a layer of a globular protein over the layer of adhesive, binding a crosslinking agent to the protein layer, and binding the protein catalyst by reaction with the crosslinking agent.... Agent: Harness Dickey & Pierce, P.L.C

20100068785 - Spinosyn-producing polyketide synthases: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.... Agent: Dow Agrosciences LLC

20100068786 - Methods and compositions for reversing p-glycoprotein medicated drug resistance: A method for inhibiting therapeutic drug resistance within a cell over-expressing a membrane protein is provided. The method comprises synthesizing a dimeric prodrug inhibitor of a monomeric therapeutic agent; administering the dimeric prodrug inhibitor to the membrane protein together with the monomeric therapeutic agent; and occupying at least one substrate... Agent: Bose Mckinney & Evans LLP

20100068787 - Novel staphylococcus aureus: bacteriophage and uses thereof: The present invention is directed to isolated bacteriophage having strong lytic activity against strains of Staphylococcus aureus, in particular, MRSA, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of Staphylococcus aureus in various settings.... Agent: Hunton & Williams LLP Intellectual Property Department

20100068788 - Novel microorganism capable of microbially decomposing chloro-, methylthio- and methoxy-triazine agrichemicals: Disclosed are: a novel microorganism which can decompose a methylthiotriazine compound (particularly, simetryn, dimethametryn, prometryn), a chlorotriazine compound (particularly, simazine, atrazine, propazine) and a methoxytriazine compound (particularly, simeton, atraton, prometon) which have been frequently used as agrichemicals or the like; and a method for decomposing a methylthiotriazine compound, a chlorotriazine... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100068789 - Ammonium transporter promoters for gene expression in oleaginous yeast: The promoter region associated with the Yarrowia lipolytica ammonium transporter (yat1) gene has been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The promoter regions of the instant invention have been shown to be advantageously inducible under oleaginous conditions (i.e., nitrogen limitation) and are... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100068790 - Non-recombinant saccharomyces strains that grow on xylose: The present invention relates to methods for producing Saccharomyces strains that are capable of growth on xylose as a sole carbon source at a desired growth rate (such as at least one generation per 48 hours), strains made by such methods, and Saccharomyces strains that grow at a growth rate... Agent: Fish & Richardson PC

20100068791 - System and method for continuous fermentation of algae: The present invention is a method for fermentation of algae or algaefaction method. The method includes feeding a hydrocarbon composition into a gasifier and pre-heating a biomass stream from a fermentation reactor. The biomass stream includes a liquid portion, a catalyst, and a biomass solids portion ranging between 15-92% by... Agent: Egbert Law Offices

20100068792 - Method for the volume and bulk reduction of domestic waste: A method for the volume and bulk reduction of domestic waste is disclosed, comprising comminution of the domestic waste, separation of the organic fraction of the domestic waste, generation of biogas from the separated organic fraction by anaerobic fermentation along the principal of dry fermentation in a biogas plant, relocation... Agent: Morrison & Foerster, LLP

20100068793 - Devices and methods for production of cell aggregates: A microwell device comprises a fluid vessel having a bottom region. A microwell plate is at the bottom region. The microwell plate comprises an upper region defining an upper plane. A plurality of microwells extend downwardly from the upper plane. Each of the microwells comprises an axis extending perpendicularly to... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20100068794 - Cell fusion chip: (Means for Solving Problems) The present invention provides a cell fusion chip comprising: an isolation chamber for receiving isolated cells to be subjected to an fusion operation; a fusion chamber for fusing the cells together supplied from the isolation chamber; a culture chamber for culturing the cells fused in the... Agent: Lawson & Weitzen, LLP

20100068796 - Blood glucose tracking apparatus and methods: A measurement module for glucose testing includes a glucose testing measurement module housing, a test strip receptacle formed in the housing, and a connector portion formed in the housing and shaped to permit mechanical removable attachment of the housing to a hand-held computer. Electronics determine the amount of glucose present... Agent: Abbott Diabetes Care Inc. Bozicevic, Field & Francis LLP

20100068795 - Blood test device: It is intended to make it easy to recognize the attachment site of a blood sensor in a blood test device to which the blood sensor is attached by insertion. Especially, it is attempted to make the recognition of the attachment site easy and facilitate the insertion of a blood... Agent: Greenblum & Bernstein, P.L.C

20100068798 - Intelligent multifunctional medical device apparatus and components: The multifunctional medical device contains system on chip (SoC) computation functionality to organize several functional modules consisting of analytical, diagnostic and therapeutic tasks in the microfluidic assembly. Micro-valves, micro-tubes, micro-wires and gates organize the chambers of the flexible modules which hold multiple chemical and biological agents for combination on demand.... Agent: Neal Solomon

20100068797 - Method for the visual detection of specific antibodies by the use of lateral flow assays: e

20100068799 - Organic substance detecting device and its manufacture method: A plurality of gold fine particles are discretely dispersed on and fixed to a principal surface of a substrate. Each of molecular probes is bonded to the gold fine particle at one end of the molecular probe. The molecular probe fixes a target capture portion at a tip thereof. The... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100068800 - Systems and methods for generating compost: Systems and methods for the generation of compost are provided. In one embodiment, the system for generating compost comprises a positively aerated floor, a semi gas and liquid impermeable compost cover sized to cover a compost biomass pile placed on the positively aerated floor, and a suction system positioned under... Agent: Speckman Law Group PLLC

20100068801 - Closed photobioreactor system for continued daily in situ production of ethanol from genetically enhanced photosynthetic organisms with means for separation and removal of ethanol: The invention provides a device for growing genetically enhanced aquatic photoautotrophic organisms in a stable culture, causing said organisms to produce ethanol, and then separating, collecting, and removing the ethanol in situ.... Agent: Algenol Biofuels, Inc.

20100068802 - Novel human androgen receptor alternative splice variants as biomarkers and therapeutic targets: The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate... Agent: Nevrivy Patent Law Group P.l.l.c

20100068803 - Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof: Polynucleotide and polypeptide sequences for HFE2A, as well as mutations associated with juvenile hemochromatosis, and methods of utilizing these for the screening and identification of agents for the treatment of diseases of iron metabolism, including small organic compounds, are disclosed along with methods of treating and/or ameliorating diseases of iron... Agent: Alan J. Grant, Esq. C/o Carella, Byrne, Bain, Gilfillan,

20100068804 - Methods of stimulating expansion of hematopoietic stem cells: The present invention relates, in general, to hematopoietic stem cells (HSC) and, in particular, to methods of stimulating expansion of hematopoietic stem cells and to agents suitable for use in such methods.... Agent: Nixon & Vanderhye, PC

20100068806 - Novel methods and reagents directed to production of cells: The present invention provides methods and materials to modulate and grow stem cells by contacting stem cells with a binder recognizing terminal glycan structures of stem cells. The modulation can be morphological change, change in differentiation status, biological status or adherence. The materials provided in the present invention are also... Agent: Birch Stewart Kolasch & Birch

20100068805 - Xeno-free culture conditions for human embryonic stem cells and methods thereof: The present disclosure provides novel culture system and methods for culturing and propagating hESCs in a substantially undifferentiated state for several passages. The ability to grow such cells without differentiation has important applications for therapeutic uses of ES cells for treating human disorders using tissue transplantation and/or gene therapy techniques.... Agent: Schwegman, Lundberg & Woessner, P.A.

20100068807 - Interferon-alpha regulator: An object of the present invention is to elucidate the role of IKKα in TLR signaling and provide an agent and a method for controlling interferon-α. The present invention provides an agent for suppressing interferon-α production which comprises an agent for inhibiting IKKα.... Agent: Greenblum & Bernstein, P.L.C

20100068809 - Reproductive cell function preservation system: Compositions or extracts (2)(15)(24)(25)(16)(23)(31)(36)(41) obtained from the fruit (4) or leaves (26) of plants of the genus Hippophae (1) and methods of using such compositions or extracts to reduce loss of reproductive cell function.... Agent: Cr Miles, P.C. Craig R. Miles

20100068808 - Tubular nanostructure targeted to cell membrane: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form... Agent: Searete LLC Clarence T. Tegreene

20100068810 - Methods and compositions for growth of embryonic stem cells: The present invention provides methods and compositions for establishing and maintaining growth of undifferentiated stem cells. In particular, the present invention provides synthetic growth matrices for stem cells, wherein said cells are capable of going through multiple passages while remaining in an undifferentiated state.... Agent: Casimir Jones, S.c.

20100068811 - Cardiac stem cells: Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic... Agent: Banner & Witcoff, Ltd.

20100068812 - Method for increasing transformation efficiency in plants, comprising coculture step for culturing plant tissue with coculture medium containing 3, 6-dichloro-o-anisic acid: m

20100068813 - Apoptotic cell-mediated transfection of mammalian cells with interfering rna: Mammalian host cells for use in a cell-mediated tranfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of downregulating a chosen target gene. Living cells expressing the... Agent: Sheldon Mak Rose & Anderson PC

20100068814 - Multi-microrna methods and compositions: Provided are DNAs comprising a polynucleotide that encodes at least a first modified miR-30 precursor and a second modified miR-30 precursor. Also provided are vectors comprising the the DNAs, where the vector can replicate in a host cell. Additionally, specific lentiviral vectors comprising the above-described DNA are provided, as are... Agent: Amster, Rothstein & Ebenstein LLP

20100068815 - Site-specific recombination systems for use in eukaryotic cells: Prokaryotic recombination systems have been adapted to function in eukaryotes in order to achieve one or more of the following: DNA site specific excision, translocation, integration and inversion. These recombination systems are identified as seven members of the small serine resolvase subfamily: CinH, ParA, Tn1721, Tn5053, Tn21, Tn402, and Tn501... Agent: Usda-ars-office Of Technology Transfer Patent Advisors Office

20100068816 - Genetically engineered herbicide resistance for maintaining axenic cultures: This disclosure provides herbicide resistant algae and cyanobacteria. This disclosure also provides a method to cultivate algae and cyanobacteria in axenic cultures without contaminating species. Moreover, this disclosure provides transgenic algal and cyanobacterial cells that are capable of high production in high light intensities as typically applied in cultivation. Furthermore,... Agent: Dodds & Associates

  
03/11/2010 > patent applications in patent subcategories. listing by industry category

20100062413 - Method of evaluating ibd, amino acid data processor, amino acid data-processing method, amino acid data-processing system, amino-acid data-processing program and recording medium: According to the method of evaluating IBD of the present invention, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and an inflammatory bowel disease state in the subject is evaluated based on the measured amino acid... Agent: Foley And Lardner LLP Suite 500

20100062412 - Method of removing abnormal prion protein from blood products: Provided are a method of conveniently and efficiently removing abnormal prion protein from a blood product and a method of removing leukocyte simultaneously with abnormal prion protein. The method of removing an abnormal prion protein from a blood product includes filtering the blood product through a filter filled with a... Agent: Greenblum & Bernstein, P.L.C

20100062414 - Sample liquid analytical chip: A sample liquid analytical chip that whilst being of simple structure, has a reaction region and a detection region isolated from each other and further has liquid feed control means for a sample liquid, thereby realizing speedy reliable analysis. The sample liquid analytical chip comprises a tubular sample liquid transfer... Agent: Greenblum & Bernstein, P.L.C

20100062421 - Compositions, methods, and devices for isolating biological materials: Compositions, methods, devices, and kits, which include an immobilized-metal support material comprising a substrate having a plurality of —C(O)O− or —P(O)(—OH)2-x(—O−)x groups bound to the substrate and a plurality of metal ions, My+, bound to the —C(O)O− or —P(O)(—OH)2-x(—O−)x groups; wherein M is selected from the group consisting of zirconium,... Agent: 3m Innovative Properties Company

20100062416 - Immobilisation and application of antigenic carbohydrates to detect infective micro-organisms: The invention relates to the field of chemistry and diagnosis, more in particular to diagnosis of current and/or past and/or symptomless infections or of a history of exposure to a gram-negative-bacterium (such as an enterobacteriaceae or a legionella). Even more in particular, the invention relates to the screening of animals... Agent: Traskbritt, P.C.

20100062418 - Inactivated and dried biological preparations: In one aspect, the present invention provides biological sample that includes a dry preparation comprising a stabilizer and stabilized, inactivated biological material. In certain embodiments, the biological material may be heat inactivated and/or heat dried. In another aspect, the present invention provides a method of making a dried biological preparation.... Agent: 3m Innovative Properties Company

20100062419 - Infectious, chimeric hepatitis c virus, methods of producing the same and methods of use thereof: The present invention provides infectious recombinant Hepatitis C Viruses (HCV), and vectors, cells and animals comprising the same. The present invention provides methods of producing infectious recombinant HCV, and their use in identifying anti-HCV therapeutic agents, as well as sequences of HCV associated with HCV pathogenesis.... Agent: Thompson Coburn LLP

20100062415 - Pathogen detection biosensor: The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne pathogens, bacteria, viruses and the like. Also described is an emittor cell comprising a receptor, wherein the receptor can be an antibody or an Fc... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100062420 - Type i interferon-inducible proteins to detect viral infection: A method for determining the presence of a viral infection in an animal not known to have been infected with a virus or other disease-causing microbial organism by determining the level of Mx protein or other Type I Interferon-inducible protein in the animal.... Agent: Howard Eisenberg, Esq.

20100062417 - Zeolite crystals with biological material: The invention provides a hybrid construct comprising at least a zeolite crystal and at least one biological moiety such as for example a cells bacteria or virus and a method for the production thereof.... Agent: Mots Law, PLLC

20100062440 - markers for cancer: The present invention relates to novel markers for hypermethylation of gene promoters in cancers. In particular the present invention relates to a method of determining whether a tumour is developing in the aero-digestive system, or whether a subject is relapsing after treatment of such a tumour. The method comprises determining... Agent: Knobbe Martens Olson & Bear LLP

20100062426 - Agr2 and tff3 regulation in the diagnosis and treatment of cancer: A method for assessing tumor progression is described by assessing AGR2 and/or TFF3 expression in a biological sample after induction of a physiological stress, such as hypoxia or serum deprivation in an enriched sample. Assessing the role of these indicators and their expression levels in an enriched CTC sample provides... Agent: Philip S. Johnson Johnson & Johnson

20100062424 - Assessment of infectious bacteria: Disclosed herein are methods for determining whether an opportunistic bacterium is infectious.... Agent: Schwegman, Lundberg & Woessner, P.A.

20100062441 - C-met mutations and uses thereof: The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns methods and compositions useful for diagnosing and treating human lung cancer associated with mutated c-Met.... Agent: Ballard Spahr LLP

20100062425 - Cat allergen: The invention relates to a method for determining the level of Fel d1 expression in a cat, the method comprising: a) typing one or more polymorphic positions of the Fel d1 gene in a sample from the cat; and b) thereby determining the level of Fel d1 expression.... Agent: Fulbright & Jaworski, LLP

20100062442 - Cell detection: In one aspect the present invention provides a method of identifying a cell or cell colony which produces a polypeptide of interest, the method comprising exposing one or more cells to a marker compound which associates with a reference polypeptide, wherein production of the polypeptide of interest by the cells... Agent: Townsend And Townsend And Crew, LLP

20100062445 - Chromosome 1p36 polymorphisms and low bone mineral density: The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100062434 - Detection of chromosomal inversions: A method and a kit for the identification of chromosomal inversions is described. Chromosomal inversions are difficult to detect unless they are quite large. The improved ability to detect chromosomal inversions is important to a number of medical applications, such as cancer and birth defects, as examples. Reporter species are... Agent: Cochran Freund & Young LLC

20100062429 - Fluorochromes for organelle tracing and multi-color imaging: Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location... Agent: Enzo Biochem, Inc.

20100062423 - Fret probes for fluorescent detection of the esps gene: The present invention relates to a primer pair for the detection of a specific gene, and more particularly to a probe pair for the detection and analysis of an EPSPS (5-enolpyruvylshikimate-3-phosphate synthase) gene, in which primers complementary to the base sequences in the EPSPS gene are labeled with fluorophores acting... Agent: Staas & Halsey LLP

20100062433 - Kit for detection/quantification of analyte, and method for detection/quantification of analyte: Disclosed are a detection/quantification kit and a detection/quantification method for detecting/quantifying an analyte rapidly at a low cost and in a simple manner. Specifically, disclosed is a kit for detecting an analyte in a sample, comprising a first conjugate and a second conjugate, wherein the first conjugate comprises a first... Agent: Hoffmann & Baron, LLP

20100062430 - Method and kit for molecular chromosomal quantification: Diagnosis of chromosomal abnormalities or genetic disorders is performed using at least two marker sequences, wherein one marker sequence is a sequence known to be present on the chromosome or in the gene of interest, another marker sequence is a sequence known to be present on an autosomal chromosome, and... Agent: Morrison & Foerster LLP

20100062439 - Method for detecting cyst nematodes: The present invention relates to a method for determining the presence of a cyst nematode in a sample comprising the steps of : providing a pair of bidirectional oligonucleotide primers or an oligonucleotide probe that hybridizes specifically, under stringent hybridization conditions, to a nucleic acid sequence encoding the SSU rRNA... Agent: Swanson & Bratschun, L.L.C.

20100062427 - Method for detecting disease-associated mutations: A method is described for diagnosing individuals as having hypertrophic cardiomyopathy, e.g. familial or sporadic hypertrophic cardiomyopathy. The method provides a useful diagnostic tool which becomes particularly important when testing asymptomatic individuals suspected of having the disease. Symptomatic individuals have a much better chance of being diagnosed properly by a... Agent: Wolf Greenfield & Sacks, P.C.

20100062432 - Method of detecting or quantitating endogenous wheat dna and method of determining contamination rate of genetically modified wheat in test sample: An object of the present invention is to discover an endogenous wheat sequence satisfying the conditions of: a) it is universally present in varieties of wheat, b) the amount present (detected amount) is not affected depending on the wheat variety, c) even if other grains are present, only wheat can... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100062428 - Methods for collecting and detecting oligonucleotides: Methods, pharmaceutical compositions, and kits are provided which includes accurately sampling a RNA from a tissue of an animal and analyzing RNA in the tissue of the animal as an indicator of physiological state, infectious disease, neoplastic disease, autoimmune disease, inflammatory disease, cardiovascular disease, atherosclerotic disease, or neurological disease in... Agent: Searete LLC Clarence T. Tegreene

20100062436 - Methods for detection of a single- or double-stranded nucleic acid molecule: t

20100062447 - Methods for identifying cancer risk: The present invention provides methods and kits for identifying an increased risk of developing cancer in a subject. The methods include analyzing a first biological sample, such as a blood sample, from the subject for loss of imprinting of the IGF2 gene. According to the methods a loss of imprinting... Agent: Dla Piper LLP (us)

20100062435 - Methods for stem cell production and therapy: The present invention relates to methods for rapidly expanding a stem cell population with or without culture supplements in simulated microgravity conditions. The present invention relates to methods for rapidly increasing the life span of stem cell populations without culture supplements in simulated microgravity conditions. The present invention also relates... Agent: Stites & Harbison, PLLC

20100062443 - Methods for the diagnosis and treatment of lung cancer: The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition.... Agent: Foley & Lardner LLP

20100062438 - Natural selection and cellular immortality: The invention provides new insights into the manner in which cells evolve and age thereby providing methods for assessing and studying those processes.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100062422 - Optical component for observing a nanometric sample, system comprising same, analysis method using same, and uses thereof: The invention concerns an optical component for observing a sample, which includes a substrate and at least one complex index layer of predetermined thickness, designed to show a high intensity or color contrast for optical path variations, reliefs, nanometric thicknesses and diameters when it is observed by incoherent light reflection... Agent: Blank Rome LLP

20100062437 - Parallel profilling of signaling pathways: Methods for identifying signaling pathways that regulate the expression of a test gene are provided.... Agent: Amster, Rothstein & Ebenstein LLP

20100062448 - Protein kinase c zeta as a drug target for arthritis and other inflammatory diseases: The present invention is based on the discovery that ζPKC expression is increased in the tissues of arthritis patients as compared to normal individuals. Accordingly, the present invention provides methods of diagnosing, prognosing, and monitoring the course of arthritis in a patient based on increased ζPKC gene expression in arthritic... Agent: Wyeth LLC Patent Law Group

20100062446 - Reactor plate and reaction processing method: Disclosed herein is a reactor plate which prevents the entry of foreign matter from the outside and the pollution of an outside environment. The reactor plate includes sealed reaction wells (5), reaction well channels (13, 15, 17) connected to the reaction wells (5), a sealed well (35) provided separately from... Agent: Cheng Law Group, PLLC

20100062444 - Tle3 as a marker for chemotherapy: Methods of using TLE3 as a marker for predicting the likelihood that a patient's cancer will respond to chemotherapy. Methods of using TLE3 as a marker for selecting a chemotherapy for a cancer.... Agent: Choate, Hall & Stewart LLP

20100062431 - Use of adamts4 gene and protein polymorphisms: The use of the single nucleotide polymorphism (SNP) of the ADAMTS4 gene for the identification of cardiovascular and peripheral vascular disorders or of an increased risk for developing cardiovascular and peripheral vascular disorders in a biological sample taken from an individual to be examined; the use of ADAMTS4 for identifying... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100062451 - Bead-ligand-nascent protein complexes: Bead-ligand-nascent protein complexes, and method of creating and detecting a bead-ligand-nascent protein complexes, are described. PCR-amplified product which is attached to a surface, e.g. of a bead, is used to generate nascent protein, which in turn is captured on the bead and detected, e.g. by fluorescence.... Agent: Medlen & Carroll, LLP

20100062457 - Biomarkers, kits, and method for diagnosing, monitoring, and/or staging alzheimer's disease: The present invention is directed to a biomarker and kit for diagnosing, monitoring and/or staging Alzheimer's disease comprising redox-reactive autoantibodies. The present invention is also directed to a method for diagnosing, monitoring and/or staging Alzheimer's disease which comprises conducting a blood test using the same.... Agent: Antonelli, Terry, Stout & Kraus, LLP

20100062454 - Method for predicting risk of acquiring influenza: An object of the present invention is to provide a method for predicting the risk of acquiring influenza, which is characterized by low price, low invasiveness, and applicability to total automation. The present invention provides a method for predicting the risk of acquiring influenza, which comprises measuring the ratio of... Agent: Birch Stewart Kolasch & Birch

20100062453 - Method of diagnosing endometriosis in human subjects: A method for diagnosing endometriosis in a human subject comprising the steps of detecting a test amount of an antibody that specifically binds to ME-5 (SEQ ID NO:3) polypeptide or a peptide comprising an epitope of ME-5 in a sample from the subject; and comparing the test amount with a... Agent: Siemens Corporation Intellectual Property Department

20100062449 - Method of measuring ptx3 with high sensitivity: To provide a method of determining vasculopathy, which is a risk factor of myocardial infarction, angiopathic dementia, etc., at an early stage thereof (i.e., mild vasculopathy). The present invention provides a method of determining the severity of mild vasculopathy, including determining PTX3 level in an assay sample by use of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100062450 - Methods and kits for early detection of cancer or predisposition thereto: Methods and kits for diagnosing cancer or a pre-malignant lesion by determining the presence and/or level of circulating CD24 of a subject are provided. Also provided are methods and kits for determining if a subject is predisposed to gastrointestinal cancer by the determining the presence or absence, in a homozygous... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100062452 - Methods for determining signal transduction activity in tumors: The method of the invention pertains to determining the signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20100062458 - Monoclonal and polyclonal antibodies to equine albumin and hemoglobin and apparatus and methods using the antibodies in the identification and localization of ulcers and other digestive tract bleeding in equines: A diagnostic and testing apparatus and related methods for the use of the same are disclosed which derive and use antibodies to equine albumin and equine hemoglobin in testing apparatus, kits, and methods for detecting and localizing gastric and colonic ulcers or bleeding in horses. Fecal droppings from a horse... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator

20100062455 - Rapid detection of cholinesterase inhibitors: The present invention relates to a rapid, high-throughput detection method for screening of potential casualties exposed to a cholinesterase inhibitor. A kit is provided for conducting the method that requires only a small volume of sample such as blood for detection and has a rapid screening throughput for multiple casualties.... Agent: Cohen, Pontani, Lieberman & Pavane LLP

20100062456 - T2r, a novel family of taste receptors: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.... Agent: Townsend And Townsend And Crew, LLP

20100062459 - Tacrolimus standard and methods of using same: A composition and kit useful as a tacrolimus standard solution for immunoassays, and methods for making and using same. The composition and kits include a known amount of tacrolimus or a derivative thereof, and a non-specific protein capable of forming a complex with the tacrolimus or derivative thereof. The standard... Agent: Siemens Corporation Intellectual Property Department

20100062461 - Multiplex detection of cell surface receptors or immobilized antigens: The present invention provides an antibody-based multiplex detection method for identifying one or more epitopes in one or more samples, the method comprising the steps of: (a) contacting each of the samples comprising the epitopes with one or more antibodies specific to the epitopes to be detected; (b) washing unbound... Agent: Law Offices Of Albert Wai-kit Chan, PLLC

20100062460 - Novel fluorochromes for organelle tracing and multi-color imaging: Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location... Agent: Enzo Life Sciences, Inc. C/o Enzo Biochem, Inc.

20100062462 - Immunodeficiency viruses: This document relates to methods and materials involved in detecting, monitoring, and prognosing immunodeficiency virus infections. For example, methods and materials for determining whether or not a mammal (e.g., a human) has an immunodeficiency virus infection (e.g., an HIV infection), methods and materials for determining whether or not a mammal... Agent: Fish & Richardson P.C.

20100062463 - In vitro multiparameter determination method for the diagnosis and early diagnosis of neurodegenerative disorders: In vitro multiparameter method for the diagnosis and early diagnosis, for determination of the severity and for assessing the course and prognosis of neurodegenerative disorders, in which the concentrations of at least two different vasotropic peptides are determined in a biological fluid from a person suffering from subjective or objectively... Agent: Heslin Rothenberg Farley & Mesiti PC

20100062464 - Oxidative chromogenic compound or salt thereof and production method thereof, and reagent composition and test instrument using the same:

20100062465 - Detection of histone deacetylase inhibition: Provided are compositions and methods for intracellular detection of enzyme activity. One example of a composition is a histone deacetylase substrate comprising a compound of the following formula (I): One example of a method is a method for detecting histone deacetylase activity comprising introducing a compound according to formula (1)... Agent: Baker Botts L.l.p

20100062467 - Medium for detecting and/or identifying bacteria: The invention relates to a method for detecting and/or identifying Escherichia coli (E. coli) in a biological sample, that comprises inoculating the biological sample liable to contain E. coli on a detection medium that comprises tryptophan and a substrate for an enzyme A, expressed by the majority of E. coli,... Agent: Oliff & Berridge, PLC

20100062466 - Medium for the detection and/or identification of bacteria: e

20100062468 - Methods and products related to low molecular weight heparin: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.... Agent: Wolf Greenfield & Sacks, P.C.

20100062470 - Luminogenic compounds and methods to detect cytochrome p450 3a enzymes: Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions.... Agent: Michael Best & Friedrich LLP

20100062469 - Method of measuring 1,5-anhydroglucitol in whole blood, and sensor chip and measurement kit to be used in the method: By a method for measuring 1,5-anhydroglucitol, comprising the steps of: eliminating or converting glucose interfering with the measurement of 1,5-anhydroglucitol and/or a derivative thereof beforehand; and measuring 1,5-anhydroglucitol performed thereafter, wherein such glucose and/or a derivative thereof are/is eliminated or converted in whole blood as such without performing blood cell... Agent: Nields, Lemack & Frame, LLC

20100062476 - Assessing mammals for vascular diseases and valvular diseases: This document provides methods and materials related to assessing mammals for vascular disease. This document also provides methods and materials related to assessing mammals for valvular disease. For example, methods and materials for assessing mammals for vascular disease using elevated levels of endothelial progenitor cells expressing a bone-related polypeptide (e.g.,... Agent: Fish & Richardson P.C.

20100062472 - Biomarkers for diagnosing multiple sclerosis, and methods thereof: The present invention describes methods for the diagnosis and differential diagnosis of the different forms of multiple sclerosis The methods measure the intensities of specific small molecules called metabolites in samples from patients with clinically diagnosed relapsmg-remittmg or primary-progressive forms of multiple sclerosis and compare these intensities to the intensities... Agent: Nixon Peabody LLP - Patent Group

20100062471 - Biomarkers for multiple sclerosis and methods of use thereof: Biomarkers useful for identifying treatments for and monitoring treatment of patients with multiple sclerosis (MS) are provided, as well as methods for their identification, methods of diagnosing MS, relapse of MS patients and disease progression in MS patients.... Agent: Sheridan Ross PC

20100062480 - Device, system and method for storing and sorting cellular samples: The present invention discloses a sample sorter system adapted to receive and sort samples according to predetermined criteria. The sample sorter system comprises a receptacle that is adapted to receive and retain fluid and samples. The receptacle is operatively coupled with a drive and with a power source such that... Agent: Fleit Gibbons Gutman Bongini & Bianco Pl

20100062478 - Drug for analysis of water transport function of membrane protein in biological tissue: The present invention is to provide a drug for analysis of a water transport function of a membrane protein in a biological tissue, wherein the abundance of one or both of 17O water molecules or 18O water molecules in the drug is greater than their abundance in natural water. Furthermore,... Agent: Nixon & Vanderhye, PC

20100062473 - Immunity evaluation method, immunity evaluation apparatus, immunity evaluation program and data recording medium having the immunity evaluation program stored therein: An immunity evaluation method for evaluating immunity by using immune cell markers for immune cells contained in sampled blood comprises the step of determining an evaluation value for each of two or more selected kinds of immune cell markers based on the individual immune cell markers contained in the sampled... Agent: Hoffmann & Baron, LLP

20100062479 - Method and device:

20100062474 - Method for the purification of at least one target substance that is to be identified: Disclosed is a method for purifying at least one target substance that is to be identified and is present or is formed in a cell culture medium when cells are cultivated. In said method, magnetic particles, i.e. beads, to the functionalized surface of which the target substance selectively attaches, are... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20100062477 - Methods of isolating and propagating stem cells from benign tumors: The present invention describes benign tumor stem cells, a method of isolating the benign tumor stem cells, a method of generating the benign tumor stem cells and a method of using the benign tumor stem cells. Uses of the benign tumor stem cells, such as pituitary stem cells include but... Agent: Davis Wright Tremaine LLP/los Angeles

20100062475 - Particle for medical use, particle for anlaysis and method of producing the same: The object of the present invention is achieved by a particle for medical use which has on the surface thereof a polymer-containing layer formed by introducing a polymerizable functional group or a chain-transfer group to the surface of a core particle, mixing the resultant particle with a polymerizable component containing... Agent: Smith, Gambrell & Russell

20100062481 - Methods of assaying sensitivity of cancer stem cells to therapeutic modalities: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem... Agent: Scully Scott Murphy & Presser, PC

20100062482 - Fermentation device comprising a coupled substrate and sediment transport mechanism and method for operating the fermentation device: A fermentation device for biological degradation of substrate containing organic material and for recovery of biogas produced by degradation has an elongate closed container having a first end and a second end opposite the first end. The first end has an inlet opening for untreated substrate and the second end... Agent: Gudrun E. Huckett Draudt

20100062483 - Production of bio-based materials using photobioreactors with binary cultures: A method, device and system for producing preselected products, (either finished products or preselected intermediary products) from biobased precursors or Co2 and/or bicarbonate. The principal features of the present invention include a method wherein a binary culture is incubated with a biobased precursor in a closed system to transform at... Agent: Battelle Memorial Institute Attn:IPServices, K1-53

20100062489 - Duck embryonic derived stem cell lines for the production of viral vaccines: The present invention relates to the development and manufacturing of viral vaccines. In particular, the invention relates to the field of industrial production of viral vectors and vaccines, more in particular to the use of avian embryonic stem cells, preferably the EBx® cell line derived from duck embryonic stem cells,... Agent: Buchanan, Ingersoll & Rooney PC

20100062487 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the... Agent: Millennium Pharmaceuticals, Inc.

20100062485 - Novel hansenula polymorpha gene coding for dolichyl-phosphate- mannose dependent alpha-1,3 mannosyltransferase and process for the production of recombinant glycoproteins with hansenula polymorpha mutant strain deficient in: The present invention relates to a process for producing a human-type glycoprotein having reduced glycosylation by genetically manipulating an enzyme involved in glycosylation using a Hansenula polymorpha system. In detail, the present invention relates to a process for producing a human-type glycoprotein by identifying a dolichyl-phosphate-mannose dependent ¥á-1,3-mannosyltransferase gene from... Agent: Lucas & Mercanti, LLP

20100062486 - Novel protein and dna encoding the protein: The present invention provides a protein comprising the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3 (except for proteins of the amino acid sequences as shown in SEQ ID NOS: 4 to 6), and a process for industrially advantageously producing a compound that... Agent: Greenblum & Bernstein, P.L.C

20100062488 - Preparation process of recombinant human p43 protein: A process for producing human p43 protein is provided, in which the p43 protein can be used as a drug for treating solid tumor.... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100062484 - Recombinant n-glycosylated proteins from procaryotic cells: The present invention relates to recombinant N-glycosylated proteins, comprising one or more introduced N-glycosylated optimized amino acid sequence(s), nucleic acids encoding these proteins as well as corresponding vectors and host cells. In addition, the present invention is directed to the use of said proteins, nucleic acids, vectors and host cells... Agent: Covington & Burling, LLP Attn: Patent Docketing

20100062490 - Organic compounds: The invention relates to a process for the recombinant production of a heterologous polypeptide of interest, comprising, (i) cultivation of a bacterial host cell which is transformed with an expression vector which comprises a nucleic acid molecule which codes for a fusion polypeptide, the fusion polypeptide comprising a derivative of... Agent: Birch Stewart Kolasch & Birch

20100062491 - Overexpression of the chaperone bip in a heterokaryon: The present invention relates to a method for increasing the production yield of a secreted antibody or antibody fragment in a filamentous fungal host cell, comprising: recombinant expression of the antibody or antibody fragment and over-expressing a BiP chaperone protein.... Agent: Novozymes North America, Inc.

20100062492 - Method for preparing icariside ii, cosmetic composition containing the same and the use thereof for skin whitening: Disclosed are a method for preparing icariside II represented by Formula 1, which inhibits the glycosylation of glycoprotein enzyme tyrosinase by inhibiting the enzymatic activity of alpha-glucosidase, which is an enzyme in the glycosylation of tyrosinase, as well as a skin whitening composition.... Agent: Sughrue Mion, PLLC

20100062493 - Method for producing an l-amino acid or a nucleic acid: A method is described for producing an L-amino acid or a nucleic acid by culturing a microorganism having an ability to produce the L-amino acid or nucleic acid in a liquid medium in a fermentation tank containing a stirring impeller, and optionally adding seed crystals to the medium as required... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100062494 - Enzymatic oligonucleotide pre-adenylation: Methods and compositions for making and using pre-adenylated oligonucleotide sequences are provided.... Agent: Banner & Witcoff, Ltd.

20100062495 - Homologous recombination-based dna cloning methods and compositions: Methods and compositions for cloning a donor DNA molecule into an acceptor vector at a predetermined location are described. The methods are based on homologous recombination mediated by in vitro treatment of the donor DNA and the acceptor vector with an enzyme cocktail containing an exonuclease and a single-stranded DNA... Agent: Panitch Schwarze Belisario & Nadel LLP

20100062496 - L-amino acid producing microorganism and a method for producing an l-amino acid: A microorganism belonging to the family Enterobacteriaceae, which has an L-amino acid-producing ability and has been modified so that the kdp system is enhanced, is cultured in a medium to produce and accumulate an L-amino acid in the medium or cells of the microorganism, and the L-amino acid is collected... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100062497 - Microorganism producing an amino acid of the l-glutamic acid family and a method for producing the amino acid: A microorganism is cultured in a medium, and is able to produce one or two or more kinds of L-amino acids including L-glutamic acid, L-glutamine, L-proline, L-ornithine, L-citrulline and L-arginine, and is modified to increase α-ketoglutarate synthase activity. The L-amino acids are collected from the medium or the cells.... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100062498 - Polypeptide being capable of increasing the production of l-methionine, a microorganism that overexpresses said polypeptide and a process of preparing l-methionine in high yield using same: The present invention relates to a polypeptide capable of increasing the production of L-methionine in a microorganism. In particular, the present invention relates to an YgaZ and YgaH polypeptide or a complex thereof, referred to herein as YgaZH polypeptide, which are novel putative L-methionine exporters, polynucleotides encoding the same, a... Agent: Knobbe Martens Olson & Bear LLP

20100062499 - Ketoreductase polypeptides for the stereoselective production of (4s)-3-[(5s)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the... Agent: Codexis, Inc.

20100062502 - Manipulation of snf1 kinase for altered oil content in oleaginous organisms: Methods of increasing the total lipid content in a eukaryotic cell, the total content of polyunsaturated fatty acids [“PUFAs”], and/or the ratio of desaturated fatty acids to saturated fatty acids by reducing the activity of the heterotrimeric SNF1 protein kinase are disclosed. Preferably, the chromosomal genes encoding the Snf1 α-subunit,... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100062501 - Method: The present application provides a method of reducing and/or removing diglyceride from an edible oil, comprising admixing an edible oil with an acyl acceptor substrate and a diglyceride:glycerol acyltransferase, wherein the diglyceride:glycerol acyltransferase is characterized as an enzyme which in an edible oil is capable of transferring an acyl group... Agent: Frommer Lawrence & Haug

20100062500 - Method for the reesterification or esterification of side chains in polymers: e

20100062503 - Lactic acid production from concentrated raw sugar beet juice: It was found that concentrated beet juice having a Brix of at least 60 is storage-stable, is not very sensitive to infections, and can be used as fermentation substrate for lactic acid production on industrial scale with the same yield, chemical purity, optical purity, clarity and taste as lactic acid... Agent: Oliff & Berridge, PLC

20100062504 - Nerolidol, terpene, and terpene deriviative synthesis: According to one embodiment, the description relates to a method of nerolidol production. The method includes culturing a yeast strain lacking functional squalene synthase and overproducing HMG CoA reductase in synthetic medium lacking uracil and producing nerolidol. The pH of the medium may be adjusted to an acidic level to... Agent: Baker Botts L.L.P. Patent Department

20100062505 - Butanol production by metabolically engineered yeast: There are disclosed metabolically-engineered yeast and methods of producing n-butanol. In an embodiment, metabolically-engineered yeast is capable of metabolizing a carbon source to produce n-butanol, at least one pathway produces increased cytosolic acetyl-CoA relative to cytosolic acetyl-CoA produced by a wild-type yeast, and at least one heterologous gene encodes and... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100062506 - Thermotolerant ethanol-producing yeast and ethanol production method utilizing the same: The present invention provides a novel yeast strain capable of producing ethanol through fermentation with a high degree of efficiency at a temperature of 37° C. or higher, preferably a temperature ranging from 40 to 49° C. or higher, and also a method for producing ethanol by utilizing the yeast... Agent: King & Spalding

20100062507 - Method for producing fuel using stacked particle bioreactor: A bioreactor for producing synfuel from carbonaceous material includes a stacked particle heap comprising biodegradable carbonaceous material, an aerobic microbial consortium fermenting the biodegradable carbonaceous material into synfuel, and a gas impermeable barrier operatively covering the stacked particle heap. The covered particle heap is purged with at least one non-oxygenated... Agent: Dickstein Shapiro LLP

20100062508 - Droplet actuator loading and target concentration: A droplet actuator and method of providing a droplet comprising an target substance on the droplet actuator, and including discrete flow and continuous flow functionality. Discrete flow function is controlled by electrodes arranged for conducting droplet operations on a substrate surface. The continuous flow function includes a fluid path arranged... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20100062509 - Highly porous magnetic temporary fixed bed: The present invention relates to a fixed bed, for example for the isolation and/or purification of components originating from a biological system, which fixed bed comprises magnetic beads and a magnetizable fabric arranged at least in part in the fixed bed, a fluidized bed-fixed bed, which comprises the fixed bed... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100062510 - Protein exhibiting activity of pyrethrin biosynthetic enzyme, gene encoding the protein, and vector bearing the gene: (ii) a protein consisting of an amino acid sequence including one or more of a substitution, deletion, insertion, and/or addition of amino acid in the amino acid sequence shown in Sequence No. 1, in which the protein exhibits activity of pyrethrin biosynthetic enzyme.... Agent: Oliff & Berridge, PLC

20100062511 - Modified enzymes, methods to produce modified enzymes and uses thereof: The invention is directed to modified xylanases having increased stability in harsh industrial environments, such as increased pH and/or temperature.... Agent: Danisco US Inc. Attention: Legal Department

20100062512 - Purification of factor xi: The invention provides methods for purifying blood coagulation Factor XI from biological fluids, the methods comprising a step of hydrophobic charge induction chromatography (HCIC).... Agent: Traskbritt, P.C.

20100062514 - Rearranged squamous cell carcinoma antigen genes ii: The present invention relates to a SCCA1/SCCA2 fusion protein; plasmid containing the same; antibodies of said fusion protein; methods for detecting said protein; methods for diagnosing the presence or absence of SCC by determining the presence of SCCA1/SCCA2 fusion protein.... Agent: Gauthier & Connors, LLP

20100062513 - Culture media formulations for industrial application: The present invention relates to formulations of culture mediums for the industrial development of liquid starter cultures characterized by a larger number of microbial cells per volume unit of fermentation medium than the one of traditional liquid starter cultures, which number can be defined a priori depending on the formulation... Agent: Pearne & Gordon LLP

20100062515 - Microbial culture medium and microbial culture method: The microbial culture medium for growing a target bacterium contained in an antibacterial test sample is composed of a basal medium for microbial culture, and acid clay or activated clay contained in the basal medium. The microbial culture method for growing a target bacterium contained in an antibacterial test sample... Agent: Sughrue Mion, PLLC

20100062516 - Expression of class 2 mannosidase and class iii mannosidase in lower eukaryotic cells: A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manα1,3 and Manα1,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrates for further N-glycan processing in the secretory pathway.... Agent: Merck And Co., Inc

20100062517 - In situ production of microbial pigments for metal and actinide immobilization: A method is provided which uses existing populations of soil bacteria to produce quantities of melanin and pyomelanin and related pigments which will chemically reduce and chelate metals and sorb to various soil minerals to help immobilize such metals within a subsurface environment. Tyrosene and phenylalanine may be used to... Agent: J. Bennett Mullinax, LLC

20100062518 - Concentrating white blood cells for dna extraction from a leukodepleted blood sample: m

20100062519 - Portable organ and tissue preservation apparatus, kit and methods: An organ and tissue preservation and transport apparatus comprising a chamber, a temperature control mechanism and a system monitor. A medium bathes an organ within the chamber. The temperature control mechanism adjusts the temperature of the medium. The system monitors receiving and records the temperature of the chamber.... Agent: Dunlap Codding, P.C.

20100062520 - Biomaterial measuring device and manufacturing method thereof: A method of producing a biomaterial measuring device is disclosed. The method includes forming a plurality of reactions elements, to which an assay reagent is applied, on a first substrate, cutting the resulting first substrate in a unit of individual reaction element, and attaching a first substrate piece, which is... Agent: Haynes And Boone, LLPIPSection

20100062521 - Packaging device for biological analysis: A subject of the invention is a packaging device for automated biological analyses, characterized in that it comprises the sample(s) to be analyzed, reagent(s), and the information necessary to carry out one (or more) analyse(s) of a sample of biological liquid and a location intended to receive the waste products... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100062522 - Incubation system with low temperature enclosure: An incubator is fitted with an enclosure which surrounds the incubator. A cold air generation system supplies relatively cold air to a space formed between enclosure and the incubator. The system supplying the cold air can be embodied in a cart or base upon which the incubator sits. The enclosure... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100062523 - Expression of class 2 mannosidase and class iii mannosidase in lower eukaryotic cells: A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manα1,3 and Manα1,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrates for further N-glycan processing in the secretory pathway.... Agent: Merck And Co., Inc

20100062524 - Methods and compositions relating to improved lentiviral vector production systems: The present invention provides HIV-derived lentivectors which are multiply modified to create highly safe, efficient, and potent vectors for expressing transgenes for gene therapy. The lentiviral vectors comprise various combinations of an inactive central polypurine tract, a stuffer sequence, which may encode drug susceptibility genes, and a mutated hairpin in... Agent: Fulbright & Jaworski, L.L.P.

20100062525 - Optically responsive and mechanically tunable colloid-in-liquid crystal gels: Colloidal liquid crystal gels (CLCGs), sensors incorporating the CLCGs, culture substrates made from the CLCGs, and patterned films and molded articles made from the CLCGs are provided. The CLCGs are composite liquid crystal materials comprising networks of particles having liquid crystal domains dispersed therein.... Agent: Whyte Hirschboeck Dudek S.c./warf Intellectual Property Department

20100062526 - Optimized messenger rna: The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common... Agent: Lando & Anastasi, LLP

20100062527 - Induction, propagation and isolation of liver progenitor cells: The present invention relates to methods of induction and isolation of progenitor cells from stem cell cultures, specifically liver progenitor cells from human embryonic stem cell cultures. In one embodiment, the present invention provides a method of inducing hepatocyte-like progenitor cells by placing a quantity of human embryonic stem cells... Agent: Davis Wright Tremaine LLP/los Angeles

20100062528 - Method for packaging cells in culture in a low-pressure environment, and corresponding device: Method for packaging cells in culture in a low-pressure environment, and corresponding device. The invention relates to a method for packaging live cells in culture for the purpose of transporting them, wherein said cells are in a culture medium contained in at least one container, characterized in that said method... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100062529 - Apparatus and method for the deposition of biological material in a target substrate: Disclosed is a deposition apparatus (100) which is designed to deposit frozen biological material (1) in a target substrate (2) and includes a charging device (10) and a driving device (20). The charging device (10) is designed to supply the biological material (1) to the driving device (20) while the... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20100062530 - Cell culture method, cell culture system and culture medium adjustement apparatus: adjusting the pH of said culture medium to be added to be higher than the pH which is optimum for culture of the cells, and/or adjusting the partial pressure of dissolved carbon dioxide of the culture medium to be added to be lower than the pressure which is optimum for... Agent: Kanesaka Berner And Partners LLP

20100062531 - Rgd containing recombinant gelatin: The invention concerns recombinant gelatins with unevenly distributed RGD motifs that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.... Agent: Morgan Lewis & Bockius LLP

20100062532 - Methods and compositions for increasing replication capacity of an influenza virus: In certain aspects, the present invention provides methods for increasing the replication capacity of influenza viruses in hens' eggs and/or cell culture, recombinant and/or reassortant influenza viruses with increased replication capacity, and immunogenic and vaccine compositions comprising such recombinant and/or reassortant influenza viruses. In other aspects, the invention further provides... Agent: Medimmune, LLC Patrick Scott Alban

20100062533 - Nuclear reprogramming factor and induced pluripotent stem cells: The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including... Agent: Greenblum & Bernstein, P.L.C

20100062534 - Inducible lentiviral vectors for reprogramming somatic cells: Described herein is a method for reprogramming a somatic cell using an inducible lentiviral vector that permits the expression of stem-cell associated genes to be turned off or on as necessary by one of skill in the art. Inducible expression of stem-cell associated genes permits the genes to be expressed... Agent: David S. Resnick

20100062535 - Psod expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

  
03/04/2010 > patent applications in patent subcategories. listing by industry category

20100055663 - Method for controlling a tissue processor and tissue processor: A method for controlling a tissue processor and a tissue processor for processing tissue samples is described. A retort is provided comprising a cover that can be opened and closed by an operator. The retort cover is closed prior to tissue processing. The actuation state of a first and a... Agent: Alexander R Schlee SchleeIPInternational P.C.

20100055666 - Biosensor with evanescent waveguide and integrated sensor: The present invention is directed to a waveguide sensor as well as to an evanescent field induced evanescent field induced sensor system for use in diagnostic housing and an integrated waveguide sensor comprising: a waveguide layer,—capture compounds applied on the upper surface of said waveguide layer for 5 specific bonding... Agent: Philips Intellectual Property & Standards

20100055664 - Enclosed membrane-clamping devices for running biological assays on membrane surfaces: An enclosed membrane-clamping (EMC) device is disclosed for running biological assays on membrane surfaces, such as Western blotting. The EMC device comprises a cover plate and a support plate, which can be coupled through a sealing mechanism. The cover plate, the support plate and the sealing mechanism are shaped such... Agent: Yiqi Luo

20100055668 - Fluid-transfer collection assembly including breakable vial and method of using same: A method of using a fluid transfer and mixing collection assembly includes depressing a flexible member to cause a force to be imparted to a breakable vial to break the vial, releasing the second fluid therein into an interior of the flexible member; releasing the flexible member to impart a... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20100055665 - Luminescence assay using macrocyclic lanthanide (iii) complexes: The invention provides a method of determining the amount of an analyte having an oxidation potential, for a one electron oxidation process, of about +0.10 to about +1.20 volts at pH 7, relative to the normal hydrogen electrode at 298K, said method comprising measuring the emission intensity or emission lifetime,... Agent: Berenato & White, LLC

20100055667 - Restricted access media and methods for making restricted access media: The present invention is directed to restricted access media (RAM), methods for preparing restricted access media, and kits for preparing restricted access media that contain protected ligand binding agents or protected enzymes. Certain RAM provided contain a plurality of protected regions of the support that contain ligand binding agents that... Agent: Thompson Coburn LLP

20100055672 - 100% sequence identity detection methods for variable genomes: The present disclosure provides methods, reagents and kits for the detection of all known human variants of influenza A virus and at least 90% of avian and swine variants of influenza A virus in a biological sample, based on amplification primers and detection probes that are specific to a highly... Agent: Knobbe Martens Olson & Bear LLP

20100055669 - Generation of recombinant genes in bacteriophages: In vivo methods for generating and detecting recombinant DNA sequences in bacteriophages or plasmids containing bacteriophage sequences, methods for generating hybrid genes and hybrid proteins encoded by these hybrid genes by the use of bacteriophages and plasmids containing bacteriophage sequences, bacteriophages and plasmids that can be used in these methods,... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B482

20100055670 - Growth of wild-type hepatitis a virus in cell culture: The invention provides recombinant Hepatitis A Virus (HAV) nucleic acids and host cells that are permissive for their growth and replication. The recombinant Hepatitis A Virus nucleic acids not particularly limited, except that they incorporate at least one heterologous nucleic acid fragment. The heterologous nucleic acid can encode a selectable... Agent: Birch Stewart Kolasch & Birch

20100055675 - Method for detecting measles virus, membrane assay test device, and membrane assay test kit: Method for detecting a measles virus in an analyte, comprising forming a complex of a first monoclonal antibody being capable of binding to a first epitope of a measles virus nuclear protein and being immobilized on a solid phase, a second monoclonal antibody being capable of binding to a second... Agent: Sughrue Mion, PLLC

20100055671 - Method for determining transduction efficiency and virus dosage of baculovirus: A method for determining transduction efficiency of baculovirus includes: providing a recombinant baculovirus, in which the recombinant baculovirus includes an inducible promoter and a reporter gene positioned downstream the inducible promoter; adding the recombinant baculovirus to incubating environment of a mammalian cell for transduction; adding an inducer to promote expression... Agent: Cooper Legal Group LLC

20100055673 - Transparent microfluidic device: A device for analysing the status of a biological entity. The device (10) comprises a substantially transparent base substrate (11) having a recess defined therein by at least two opposing lateral walls and a base wall, a substantially transparent filler member (14) having at least a portion thereof occupying the... Agent: Connolly Bove Lodge & Hutz LLP

20100055674 - Utilizing liver cell line qsg-7701 to be infected with hepatitis b virus: The use of the liver cell line QSG-7701 for HBV infection includes the following steps: directly infecting QSG-7701 cells with purified HBV particles and facilitating the infection by DMSO and/or PEG treatment. The easily available QSG-7701 liver cell line may not require pre-differentiation induction and is naturally susceptible for HBV... Agent: Osha Liang L.L.P.

20100055708 - Assay for chlamydia trachomatis by amplification and detection of chlamydia trachomatis cytotoxin gene: A region of the Chlamydia trachomatis cytotoxin gene has been identified which is useful for performing amplification assays to determine specifically whether C. trachomatis is present in the sample being tested. Oligonucleotides useful for performing thermal Strand Displacement Assay (tSDA) reactions on this gene are disclosed. The disclosed oligonucleotides can... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100055684 - Composition for nucleic acid transfection: r

20100055705 - Compositions and methods for diagnosing and treating cancer: The invention is drawn novel methods and compositions for the treatment of cancer, and for the diagnosis and prognosis of cancer in a subject. In particular aspects, the invention relates to the finding that the protein tristetraprolin (TTP) is decreased or repressed in a myriad and diversity of cancers. To... Agent: Morgan Lewis & Bockius LLP

20100055683 - Diagnosis of pulmonary and/or cardiovascular disease: Described are methods and kits for determining the likelihood of the presence of cardiovascular disease (CVD) or pulmonary disease (PD) in a subject using ST2/Interleukin 1 Receptor Like 1 (IL1RL1) and/or Interleukin 33 (IL-33), and a biomarker for CVD, e.g., a natriuretic peptide, e.g., brain natriuretic peptide (BNP), prohormone BNP... Agent: Fish & Richardson PC

20100055696 - Drg11-responsive (dragon) gene family: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100055704 - Expression profile of thyroid cancer: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization... Agent: Casimir Jones, S.c.

20100055701 - Fusion proteins for imaging the nucleus and chromosomes of live cells: Fusion proteins that fluoresce and bind DNA, as well as nucleic acid constructs encoding the same are described herein. These imaging agents function in live cells to bind DNA and are thus useful for visualizing nuclei and chromosomes to make observations of nuclear and chromosomal structure and dynamics. The imaging... Agent: Foley & Lardner LLP

20100055680 - Genomic dna labeling and amplification: Methods of amplifying genomic DNA are provided which include contacting template genomic DNA, a plurality of random primers, and a DNA polymerase, wherein the ratio of template genomic DNA to random primers is in the range of about 1:10-1:35,000,000 (w/w), inclusive, to produce a reaction mixture; and incubating the reaction... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20100055685 - Isothermal detection methods and uses thereof: The present invention relates to methods and probes for rapid, single temperature (isothermal) detection of specific nucleic acid sequences. The methods and probes provide an easily automatable system for detecting bioagents including bacteria and viruses, and the detection of specific genetic markers on any nucleic sequence.... Agent: Morrison & Foerster LLP

20100055693 - Luciferase signal enhancing compositions: Reagents and compositions for use in reactions catalysed by luciferase enzymes, and in particular for use in luciferase-based gene reporter assays are described. The invention also provides methods and compositions for, inter alia, increasing the sensitivity and/or improving the kinetics of luciferase-catalysed reactions.... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20100055695 - Method for generating aptamers with improved off-rates: The present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior SELEX and photoSELEX methods. The disclosure further describes aptamers and photoaptamers having slower dissociation rate constants than those obtained using prior methods. This invention relates to the field of diagnostic... Agent: Swanson & Bratschun, L.L.C.

20100055677 - Method for genetic identification of unknown organisms: A method of rapid, genome and proteome based identification of unknown pathogenic or non-pathogenic organisms in a complex sample. The entire sample is analyzed by creating millions of emulsion encapsulated microdroplets, each containing a single pathogenic or non-pathogenic organism sized particle and appropriate reagents for amplification. Following amplification, the amplified... Agent: Lawrence Livermore National Security, LLC

20100055692 - Method for selection of hop strain, bleeding marker for use in selection of hop strain, and primer set: m

20100055679 - Method for the quantitative analysis of the number of copies of a pre-determined sequence in a cell: The invention relates to a method for the quantitative analysis of the number of a pre-determined sequence, and optionally of sequences homologous to the pre-determined sequence, in a biological sample, whereby a defined quantity of a biological sample is subjected to at least one amplification reaction which is adapted in... Agent: Dilworth & Barrese, LLP

20100055676 - Method of assaying alpha 1, 4-n-acetylglucosamine transferase (alpha 4gnt) mrna: A method for assaying α1,4-N-acetylgiucosamine transferase (α4GnT) mRNA present in a sample, the method comprising a step of using a first primer homologous to at least a portion downstream from the 5′-end of a specified nucleotide sequence of the RNA and a second primer complementary to at least a portion... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100055699 - Method of manufacturing a semiconductor sensor device and semiconductor sensor device obtained with such method: The invention relates to a method of manufacturing a semiconductor sensor device (10) for sensing a substance (30) and comprising a strip-shaped semiconductor region (1) which is formed on a surface of a semiconductor body (11) and which is connected at a first end to a first electrically conducting connection... Agent: Philips Intellectual Property & Standards

20100055678 - Method of profiling a cell population: The present invention relates to a method of profiling a cell population comprising a step of detecting the presence or absence of at least two biological markers in said cell population, wherein at least one of said markers is a cell surface marker, which is a sialylated N-glycan marker with... Agent: Birch Stewart Kolasch & Birch

20100055686 - Methods for diagnosis of pediatric common acute lymphoblastic leukemia by determining the level of gene expression: The present invention refers to a method and a kit for diagnosing pediatric common acute leukemia by distinguishing between normal and common acute lymphoblastic leukemic (cALL) cells, wherein the method comprises the step of determining the gene expression of specific genes (markers) referring to this disease and the step of... Agent: Smith Patent Consulting, LLC

20100055707 - Methods of screening for compounds for use as modulators of left-right asymmetry in scoliotic subjects and for monitoring efficacy of an orthopaedic device: A method of screening for a compound for treating or preventing adolescent idiopathic scoliosis (AIS), said method comprising: (a) contacting a test compound with a paraspinal skin fibroblast or a paraspinal muscle cell sample from the right and/or left side of the spine of a subject; and (b) determining at... Agent: Goudreau Gage Dubuc

20100055694 - Molecular signature representative of dysfunctions in epidermal homeostasis: The present invention concerns a method for evaluating the epidermal homeostasis of the skin of a subject, comprising differential analysis of the expression of a gene, preferably of two genes, selected from the group of genes consisting of KRT6B, KRT16, ESRRA, CBX3, MAP3K5, TRIO, PIK3CD, TCRB, PRRG2, ICP22BP, GPX3, GBA,... Agent: Buchanan, Ingersoll & Rooney PC

20100055689 - Multifactorial methods for detecting lung disorders: Described herein are multifactorial methods for detecting, diagnosing or aiding in the diagnosis of lung disorders or disease, e.g., lung cancer. The methods disclosed utilize multiple diagnostic paradigms, for example, to improve diagnostic sensitivity, specificity, negative predictive value and/or positive predictive value over each of the paradigms alone. For example,... Agent: Morse, Barnes-brown & Pendleton, P.C. Attn:IPManager

20100055687 - Mutations in the bcr-abl tyrosine kinase associated with resistance to st1-571: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind... Agent: Kenyon & Kenyon LLP

20100055703 - Organism-specific hybridizable nucleic acid molecule: The present invention relates to a method for producing an organism-specific hybridizable nucleic acid molecule, a nucleic acid molecule produced by this method, a kit comprising at least any of the nucleic acid molecules, the use of a nucleotide sequence located between two elements on the genomic information of an... Agent: Marshall, Gerstein & Borun LLP

20100055702 - Pathogenecity islands of pseudomonas aeruginosa: Disclosed are Pseudomonas aeruginosa Genomic Island nucleic acid sequences referred to as PAGI-5, PAGI-6, PAGI-7, PAGI-8, PAGI-9, PAGI-10, and PAGI-11. These nucleic acid sequences may be useful in methods for identifying virulent strains of Pseudomonas bacteria.... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100055697 - Positive selection of serum proteins for proteomic analysis: This invention relates to methods and kits for positive selection of species of interest based on peptide/protein sequence from a biological sample. The species of interest may be proteins and/or peptides of interest which may be placed through a mass spectrometer to obtain a blood peptide/protein signature. The blood peptide/protein... Agent: Davis Wright Tremaine LLP/los Angeles

20100055681 - Primer-directed chromosome painting: An oligonucleotide composition is provided. The subject composition comprises: a mixture of at least 10 of sets of oligonucleotides, wherein each of the sets of oligonucleotides comprises at least 100 different oligonucleotides of the following formula: X1—V—X2, wherein: X1 and X2 provide binding sites for a pair of PCR primers... Agent: Agilent Technologies Inc.

20100055682 - Procedure and methods for detecting alzheimers's disease: This application concerns methods and compositions that can be used for detecting the Alzheimer disease in mammals, particularly in humans. It describes in particular serum markers for Alzheimer's disease and the way they are used for diagnostic procedures. It also concerns tools and/or kits that can be used for applying... Agent: Nixon & Vanderhye, PC

20100055690 - Prognostic biomarkers in patients with ovarian cancer: The present invention provides methods for assessing an ovarian cancer patient's survival status. Also, methods for evaluating the ovarian cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biological patterns in biological samples. The biological patterns are obtained using, for example, mass... Agent: Edwards Angell Palmer & Dodge LLP

20100055698 - Reactor for performing biochemical processes: A reactor (1) for performing biochemical processes, particularly for extraction, purification, enrichment, sedimentation, comprising a container which is provided with at least one mouth (2) which is associated with closure means (3) of the removable type, the container having internally at least one process compartment (4), adapted to accommodate a... Agent: Dennison, Schultz & Macdonald

20100055700 - Role of il-12, il-23 and il-17 receptors in inflammatory bowel disease: This invention provides methods of diagnosing or predicting susceptibility or protection against Inflammatory Bowel Disease in an individual by determining the presence or absence of genetic variants in the genes for IL-12, IL-23, and/or IL-17 receptors. In one embodiment, a method of the invention is practiced by determining the presence... Agent: Davis Wright Tremaine LLP/los Angeles

20100055691 - Screening method for therapeutic agent for amyotrophic lateral sclerosis: The objective of the present invention is to provide methods of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis (ALS2). The invention provides a method of screening therapeutic agents for juvenile familial amyotrophic lateral sclerosis, comprising a step of assessing a substance that suppresses the expression of Tollip in... Agent: Sughrue Mion, PLLC

20100055706 - Screening methods for transfusion related acute lung injury (trali): The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence. This invention provides methods and kits for screening for HNA-3a and HNA-3b specific antibodies, HNA-3a and HNA-3b polypeptides and HNA-3a and HNA-3b nucleic acids... Agent: Marshall, Gerstein & Borun LLP

20100055688 - Slit2 cancer markers: This invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, this invention relates to SLIT2 cancer markers that are useful as diagnostic markers and clinical targets for prostate cancer.... Agent: Casimir Jones, S.c.

20100055709 - Tubulin mutation diagnostic: The present invention relates to methods for determining the potential of a subject to respond to a particular therapeutic agent, by determining the presence of one or more nucleotide or amino acid variants in the β-tubulin gene or protein. Also provided are methods for treating subjects whose potential to respond... Agent: Novartis Corporate Intellectual Property

20100055713 - Chemiluminescence sensor array: Embodiments of the invention relate to integrated chemiluminescence devices and methods for monitoring molecular binding utilizing these devices and methods. These devices and methods can be used, for example, to identify antigen binding to antibodies. The devices include both a chemiluminescence material and a detector integrated together.... Agent: Pillsbury Winthrop Shaw Pittman LLP (intel)

20100055711 - Methods for the identification of pi3k interacting molecules and for the purification of pi3k: The present invention relates to a method for the identification of a PI3K interacting compound, comprising the steps of a) providing a protein preparation containing PI3K, b) contacting the protein preparation with phenylthiazole ligand 1 immobilized on a solid support under conditions allowing the formation of a phenylthiazole ligand 1-PI3K... Agent: Clark & Elbing LLP

20100055710 - Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof: The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on... Agent: Birch Stewart Kolasch & Birch

20100055712 - Oligopeptides for treatment of osteoporosis and other bone diseases and methods therefor: Methods of identifying compounds for treating Alzheimer's disease are disclosed. These methods comprise a) forming an in vitro mixture comprising i) cells expressing LDL receptor related protein 1 (LRP1), ii) an LRP1 ligand comprising a label, and iii) a candidate compound; and b) determining quantity of the label incorporated by... Agent: Washington University-snr C/o Sonnenschein Nath & Rosenthal L.l.p

20100055714 - Ikb kinase, subunits thereof, and methods of using same: The present invention provides an isolated nucleic acid molecules encoding IκB kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (IκB) that inhibits the activity of the NF-κB transcription factor, vectors comprising such nucleic acid molecules and host cells containing such... Agent: Medlen & Carroll, LLP

20100055718 - Nanoplate dye platform and methods of making and using the same: Embodiments disclosed herein relate to labeling reagents comprising a plurality of nanoplates attached to dye molecules. The nanoplates may be configured into stacks and/or at least partially surrounded by a surrounding layer. The reagent may then be used to label a target (e.g., structure or environment).... Agent: Edwards Angell Palmer & Dodge LLP

20100055719 - Screening method for identifying new aminoacyl-trna synthetase inhibitors: The method comprising: a) obtaining a gene sequence codifying a naturally occurring aminoacyl-tRNA synthetase; b) engineering the gene codifying for said aminoacyl-tRNA synthetase, resulting into an aminoacyl-tRNA synthetase with a defective activity, with the proviso that the engineering does not affect the functionality of the catalytic site of the enzyme;... Agent: Berenbaum Weinshienk PC

20100055720 - Use of the 4-lbb receptor for identifying and/or separating activated regulatory th cells (treg): The invention relates to the use of the 4-1BB receptor for identifying and/or separating specific regulatory Th cells after activation with an antigen, polyclonal regulatory Th cells after polyclonal activation and to a method for the identification and/or separation of regulatory Th cells, the regulatory T cells being detected on... Agent: Joyce Von Natzmer Pequignot + Myers LLC

20100055721 - Surface enhanced raman scattering and multiplexed diagnostic assays: Multiplexed lateral flow assays, related methods, and devices are disclosed which are capable of simultaneously detecting multiple analytes. The assays are preferably immunoassays and can be multiplexed spatially, spectrally, and both spatially and spectrally. Multiplexed assays are disclosed employing quantum dots for applications including the detection of human proteins and... Agent: Greenlee Winner And Sullivan P C

20100055715 - Nucleic and amino acid sequences of prokaryotic ubiquitin-like protein and methods of use thereof: The present invention relates to prokaryotic ubiquitin-like protein (Pup) nucleic acid sequences and Pup amino acid sequences encoded therefrom. Also encompassed are antibodies that are immunologically specific for Pup. Methods directed to isolation and identification of pupylated substrates that utilize the conjugated Pup as an affinity tag are also included.... Agent: Klauber & Jackson

20100055716 - Detection instrument, analysis device, and detection method: A detection instrument of the present invention includes: a flow path through which a sample to be examined flows, the flow path having a plurality of detection areas in each of which a target substance in the sample is detected, the plurality of detection areas respectively including detection sections and... Agent: Birch Stewart Kolasch & Birch

20100055717 - Sampling and assay device together with methods for use thereof: An immunochemical sampling device, kits including the sampling device, processes for production of the sampling device, and methods for use of the sampling device in lateral flow immunoassays. The sampling device comprises a solid support that is partially wrapped in a porous carrier, then covered in a hydrophobic cover. At... Agent: Dla Piper LLP (us)

20100055723 - Galectin-3-binding protein as a biomarker of cardiovascular disease: The present invention provides compositions and methods for using biomarkers to diagnose and monitor cardiovascular associated diseases and disorders. More specifically, the present invention provides Galectin-3-binding protein as a biomarker for disease.... Agent: University Of Virginia Patent Foundation

20100055722 - Methods of detecting a neurological condition via analysis of circulating phagocytes: The present invention features methods of monitoring or detecting a neurological or inflammatory condition in a patient. The method comprises (1) obtaining from the patient a fluid sample from outside of a brain tissue of the patient, wherein the fluid sample contains a circulating phagocyte, and (2) detecting for one... Agent: Nguyen & Tarbet

20100055724 - Methods of detecting autoantibodies for diagnosing and characterizing disorders: Methods for detecting and/or quantitating levels of autoantibodies in subjects are provided. Methods for diagnosing and/or characterizing a disorder associated with autoantibody production are further provided. In some embodiments, the disorder diagnosed and/or characterized can be a cancer or an infertility disorder.... Agent: Stites & Harbison, PLLC

20100055725 - System for assays of aminotransferase: An assay system (300) comprising providing a platform (102) having a contact surface (104); immobilizing an amino acid group (108), having an amine side group (109), on the contact surface (104); transforming the amine side group (109), in the amino acid group (108) to a ketone group (120); and reacting... Agent: Law Offices Of Mikio Ishimaru

20100055726 - Asparaginases: The invention relates to new asparaginases having improved properties, preferably improved thermotolerance, such as improved activity at high temperatures and/or improved thermostability. The invention also relates to DNA sequences encoding such improved asparaginases, their production in a recombinant host cell, as well as methods of using the asparaginases, in particular... Agent: Novozymes North America, Inc.

20100055728 - Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity: Embodiments of the present disclosure provide for enzyme sensors, protease sensors, methods for producing and using the enzyme and protease sensors, methods of detecting and/or measuring protease activity, methods for characterizing protease cellular activity, fusion proteins, polynucleotides, and vectors corresponding to the enzyme and protease sensors, kits, and the like.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100055727 - Fret protease assays for botulinum serotype a/e toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Allergan, Inc.

20100055732 - Cardiac hypertrophy: The invention provides means and methods for at least in part inducing, counteracting, preventing and/or investigating cardiac hypertrophy.... Agent: Morrison & Foerster LLP

20100055731 - Kex2 cleavage regions of recombinant fusion proteins: The invention relates to a fusion DNA construct comprising a KEX2 region comprising a KEX2 site and a KEX2 site pre-sequence immediately 5′ to the KEX2 site, a fusion polypeptide, vectors and cells comprising the fusion DNA construct, methods for producing desired proteins from filamentous fungal cells and methods for... Agent: Danisco US Inc. Attention: Legal Department

20100055733 - Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels: Embodiments of the present disclosure encompass microfabrication methods (“reactive microcontact printing of soft matter”) for hydrated soft polymer materials and surfaces for culture platforms suitable for the culturing of isolated single primary mammalian cells in an environment approximating the natural niches of the cells. Such culture platforms may comprise arrays... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100055734 - Methods for diagnosis and intervention of hepatic disorders: The disclosure provides a method for quantification of hepatic function in a subject comprising measuring the clearance of an orally administered isotopically labeled cholic acid in a subject with, or suspected of having or developing, a hepatic disorder, for example, chronic hepatitis C. The disclosure further provides methods and kits... Agent: Merchant & Gould PC

20100055730 - Methods for the diagnosis and treatment of female infertility using molecular markers: The present invention features methods of evaluating the fertility of a female subject, or the fertilization competence of an oocyte extracted from an ovarian follicle, using measurements of one or more differentially expressed components of follicular fluid. The methods of the invention include the steps of measuring the level of... Agent: Clark & Elbing LLP

20100055729 - Sensor device: Sensor devices and compositions can be used for detecting the presence of a target substance in a medium. The sensor devices and compositions can be configured to include at least one nanosensor through a high concentration of nanosensors that interact with the target substance to provide a detectable signal as... Agent: Edwards Angell Palmer & Dodge LLP

20100055735 - Ex vivo flow cytometry method and device: n

20100055736 - Viral vector and uses thereof: The invention relates to a viral vector comprising a mutated replicon of the Semliki Forest virus (SFV) in the nucleotide sequence encoding subunit nsp2 of the SFV replicase. Said viral vector can be used to generate stable cell lines which can constitutively express heterologous products of interest.... Agent: Moore & Van Allen PLLC

20100055737 - Cyclodipeptide synthetase and its use for synthesis of cyclo(tyr-xaa) cyclodipeptides: Isolated, natural or synthetic polynucleotide and polypeptide encoded by said polynucleotide, that is involved in the synthesis of cyclodipeptides, recombinant vector comprising said polynucleotide or any substantially homologous polynucleotide, host cell modified with said polynucleotide or said recombinant vector and also methods for in vitro and in vivo synthesizing cyclodipeptides,... Agent: The Nath Law Group

20100055738 - Method for making acylated polypeptides: The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the... Agent: Novo Nordisk, Inc. Intellectual Property Department

20100055739 - Methods of improving the introduction of dna into bacterial cells: The present invention relates to methods of improving the introduction of DNA into bacterial host cells.... Agent: Novozymes, Inc.

20100055740 - Production of cellulase enzymes in plant hosts using transient agroinfiltration: Described herein are methods useful for producing proteins, such as enzymes, by agrofiltration. The methods involve producing an Agrobacterium with a Ti plasmid encoding a cellulase, infecting plant cells with the Agrobacterium, allowing expression of the cellulase, and recovering the cellulase from the plant cells. In one embodiment, the protein... Agent: Morrison & Foerster LLP

20100055741 - Materials and methods for converting biomass to biofuel: This disclosure provides for materials and methods for converting biomass to biofuels. The materials include a colloid mill with or without cellulase enzymes, and the methods include the use of a colloid mill and optionally cellulose enzymes to pretreat biomass for use in a biomass to biofuel production process.... Agent: Jason H. Vick Sheridan Ross, PC

20100055743 - Low-mass sample block with rapid response to temperature change: A sample block for use in the polymerase chain reaction, DNA sequencing, and other procedures that involve the performance of simultaneous reactions in multiple samples with temperature control by heating or cooling elements contacting the bottom surface of the block is improved by the inclusion of hollows in the block... Agent: Townsend And Townsend And Crew, LLP

20100055742 - Method for amplification of nucleotide sequence: To provide a method for electively amplifying a target nucleic acid and a method for detecting a nucleic acid by said method, which are useful as a method for synthesizing the nucleic acid. A method for amplifying a nucleic acid sequence [EVA (Endonuclease V-dependent Amplification) method] which selectively amplifies a... Agent: Sughrue-265550

20100055744 - Dna mini-circles and uses thereof: Methods and kits for generating circular nucleic acids in a cell-free system, and uses for the generated circular nucleic acids are provided. The methods comprise in vitro amplification of a nucleic acid template comprising a recombination site to produce tandem repeat nucleic acid sequence, and employ a recombination protein to... Agent: General Electric Company Global Research

20100055745 - Producing, cataloging and classifying sequence tags: The described method provides, methods, and kits to produce, identify, catalog and classify a comprehensive collection of nucleic acid targets produced from a nucleic acid sample. The method, referred to as Cataloging and Classification of Sequence Tags, involves generating a set of target nucleic acid fragments; coupling the target nucleic... Agent: Cantor Colburn, LLP

20100055746 - Method for fermentative production of n-acetyl-d-glucosamine by microorganism: N-Acetyl-D-glucosamine can be produced by cultivating a fungus capable of producing N-acetyl-D-glucosamine, such as Trichoderma hamatum AB10282 strain (FERM BP-10623) or Trichoderma harzianum AB10283 strain (FERM BP-10624), in a culture medium supplemented with a carbon source other than chitin and chitin oligosaccharide and a nitrogen source to produce and accumulate... Agent: Knobbe Martens Olson & Bear LLP

20100055747 - Method for improving yield of cellulose conversion processes: The present teachings provide methods of converting cellulosic materials to soluble sugars. Methods for increasing the yield of glucose from the enzymatic saccharification of cellulosic materials is also provided. The present teachings further provide methods of increasing the yield of cellobiose from the enzymatic saccharification of cellulosic materials.... Agent: Danisco US Inc. Attention: Legal Department

20100055748 - L-amino acid producing bacterium and method for producing l-amino acid: An L-amino acid can be produced by culturing an L-amino acid-producing bacterium which belongs to the Enterobacteriaceae family and which has been modified so that the expression of a yggG gene is enhanced.... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100055749 - Process for the production of clavulanic acid: The present invention relates to a process for preparation of a pharmaceutically acceptable metal salt of clavulanic acid comprising the steps of (a) fermenting of a microorganism capable of producing and excreting the clavulanic acid into the broth; (b) removing biomass and other solid material from the clavulanic acid containing... Agent: Nixon & Vanderhye, PC

20100055750 - Polyester synthesis: The present disclosure provides for enzymatic polymerization to produce polyester resins suitable for use in manufacturing toners. In embodiments, crystalline copolymers, which are polyesters, may be synthesized from lactones, cyclic anhydrides, cyclic carbonates, and combinations thereof. These crystalline copolymers, in turn, may be utilized in the synthesis of toner particles.... Agent: Xerox Corporation (cdfs)

20100055751 - Ketoreductase polypeptides and uses thereof: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of stereo specifically reducing (R)-2-methylpentanal to (R)-2-methylpentanol. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of... Agent: Codexis, Inc.

20100055752 - Native grain amylases in enzyme combinations for granular starch hydrolysis: Described herein are starch hydrolysis processes for obtaining fermentable sugars from starch in milled plant material at temperatures below the starch gelatinization temperature and using exogenous plant alpha amylases further to the fermentation of the sugars to produce end products, such as ethanol.... Agent: Danisco US Inc. Attention: Legal Department

20100055753 - Method for the production of concentrated alcohol from fermentation broths: A method for obtaining a concentrated alcohol solution from a lignocellulosic feedstock. The lignocellulosic feedstock is hydrolyzed to prepare a sugar solution. The sugar solution is fermented to produce a fermentation broth comprising alcohol and at least about 1 g ammonium ions/kg fermentation broth. The alcohol in the fermentation broth... Agent: Fitzpatrick Cella Harper & Scinto

20100055754 - Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels: The present invention provides methods of increasing production of an isoprenoid or an isoprenoid precursor in a host cell, the methods generally involving modulating the level of activity of a fatty acid biosynthetic pathway enzyme in the host cell and/or culturing the host cell in a culture medium comprising a... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP

20100055755 - Methods of eliminating or reducing expression of genes in filamentous fungal strains by transitive rna interference: The present invention relates to methods of reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference.... Agent: Novozymes, Inc.

20100055756 - System and method for modifying biological cells using an ultra-short pulsed laser: A system and method for modifying a biological cell are presented. A beam of ultra-short pulses is generated. The beam is delivered to a mixture that includes a biological cell and a medium. The beam is focused to form a focal zone. The focal zone may be proximate to the... Agent: Carr & Ferrell LLP

20100055757 - Stem cells and methods incorporating environmental factors as a means for enhancing stem cell proliferation and plasticity: Disclosed are methods for expanding stem cells that use a unique combination of environmental factors and cell culture conditions to produce stem cells having enhanced proliferation and differentiation characteristics. Also disclosed are methods for enhancing the engraftment and/or migratory potential of stem cells for therapeutic uses. Stem cells having unique... Agent: Stemedica Cell Technologies, Inc

20100055758 - Magnetic device for isolation of cells and biomolecules in a microfluidic environment: The present invention features a new and useful magnetic device and methods of its use for isolation, enrichment, and purification of cells, proteins, DNA, and other molecules. In general the device includes magnetic regions or obstacles to which magnetic particles can bind. The chemical groups, i.e., capture moieties, on the... Agent: Fish & Richardson PC

20100055759 - Transparent polymer membrane for laser dissection: The disclosure encompasses transparent polymer membranes suitable for use in laser microdissection methods, where the membranes allow the subsequent analysis of the microdissected cell or cells with light of a wavelength that can traverse the membrane with little if any absorbance by the membrane. The transfer capture membranes of the... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100055760 - Enzyme preparations: The invention is directed to enzyme preparations which are obtainable by providing enzyme immobilizates which comprise enzymes or microorganisms comprising enzymes immobilized on an inert support with a polyethersilicone coating obtained by hydrosilylation, to a process for preparing such enzyme preparations and to the use of enzyme preparations as an... Agent: Scully Scott Murphy & Presser, PC

20100055761 - Methods, compositions, and kits for the selective activation of protoxins through combinatoral targeting: The present invention provides methods and compositions for treating various diseases through selective killipg of targeted cells using a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting moiety and, a modifiable activation moiety which is activated by an activation moiety not naturally operably found in,... Agent: Clark & Elbing LLP

20100055762 - Method for preparation of hepatocyte using es cell: Furthermore this invention relates to a method of promoting differentiation of an ES cell, preferably a method of promoting differentiation of an ES cell into a hepatocyte, comprising the step of contacting uPA with the ES cell, or a method of preparing a hepatocyte comprising the step of contacting uPA... Agent: Birch Stewart Kolasch & Birch

20100055763 - Method for the production and purification of retroviral vectors: The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have... Agent: Fulbright & Jaworski L.L.P.

20100055764 - Cell culture apparatus and method: Cell culture apparatuses and methods for culturing cells include bags for culturing cells. The bags are folded and unfolded to control cell culture conditions. As the bags are folded, segmented sealed chambers for culturing cells are formed. As the bags are unfolded, the segments are unsealed allowing for exchange of... Agent: Corning Incorporated

20100055765 - Semi-closed loop alga-diesel fuel photobioreactor using waste water: A semi-closed loop diesel photobioreactor system and method are provided for producing diesel fuel from wild algae or from specialized algae that has been biologically modified for high efficiency oil production using waste water as a primary food source. The diesel photobioreactor provides a semi-closed loop system with an opening... Agent: Fleit Gibbons Gutman Bongini & Bianco P.l.

20100055766 - Microfluidic cartridge for separating target molecules, and separator and method of separating target molecules using same: A microfluidic cartridge includes a capture portion capturing target material on surfaces of nonmagnetic particles; and a separating portion separating target molecules from the target material captured on the surfaces of the particles. The microfluidic cartridge is mounted on an adaptor that is rotated by a rotating unit in order... Agent: Sughrue Mion, PLLC

20100055767 - Bio-energy system and apparatus: A bio-energy system includes a waste collecting station at which raw waste material such as municipal waste, household waste and the like is collected. The waste is delivered through a rotating organic material digester in a controlled manner for converting the organic waste material content of the raw waste to... Agent: Holland & Knight LLP

20100055768 - Cleaning and/or treatment compositions: This invention relates to compositions comprising certain peroxidases and processes for making and using such compositions including the use of such compositions to clean and/or treat a situs, for example fabrics and surfaces. Such compositions provide enhanced cleaning and/or treatment benefits, for example soil bleaching and whiteness maintenance.... Agent: The Procter & Gamble Company Global Legal Department - Ip

20100055769 - Biotechnological device including a structured hydrogel permeation layer: The present invention relates to a biotechnological device including a responsive hydrogel permeation layer with an intrinsic structural gradient.... Agent: Philips Intellectual Property & Standards

20100055770 - High-density multiwell-plate: A high-density multiwell-plate for performing thermocycled amplification reactions of polynucleotides in liquid samples comprising a plurality of reaction wells is disclosed. In order to provide a better thermal insulation, the plate comprises a rigid well-forming structure placed above a bottom layer, wherein substantially horizontal well-covering areas cover the liquid sample... Agent: Dinsmore & Shohl, LLP Fifth Third Center

20100055771 - Micro valve apparatus using micro bead and method for controlling the same: A micro (thin film type) valve apparatus for controlling fluid flow and its rate using microbead and a method for controlling the apparatus are provided. The microbead is moved by the magnetic forge generated by upper and lower electromagnets disposed on the top and bottom surface of the body or... Agent: Staas & Halsey LLP

20100055772 - Reagent preparing apparatus, sample processing apparatus and reagent preparing method: The present invention is to present a reagent preparing apparatus for preparing a reagent for processing a sample, by using a first liquid and a second liquid, comprising: a storage unit for storing liquid; and a constant amount liquid quantifying unit comprising a constant amount holding instrument which is used... Agent: Brinks Hofer Gilson & Lione

20100055774 - Gas permeable cell culture device and method of use: Gas permeable devices and methods are disclosed that provide more efficient cell culture.... Agent: Patterson, Thuente, Skaar & Christensen, P.A.

20100055773 - Tissue piece pinching device and culture kit: Under a state where the zipper 22 of a culture bag is opened, an operator depresses the opening button 43 of an arm 40 with one finger. Consequently, a force for oscillating the arm 40 to separate a retaining portion 49 upward from the culture surface 32 around a pin... Agent: Oliff & Berridge, PLC

20100055775 - Organic material digester: An organic material digester for the treatment of waste material which includes organic waste has an elongate rotating drum through which the waste is delivered between an inlet and outlet of the drum. Mechanical and biological activity within the drum converts the organic waste to a compost. A number of... Agent: Holland & Knight LLP

20100055776 - Bioreactor, arrangement of bioreactors, process for production thereof and use thereof: The invention relates to a bioreactor including a housing having a lower housing half and an upper housing half that are respectively connected to one another on one side by a film joint. At least one of the upper or lower housing halves includes a device to exchange fluids. The... Agent: Venable LLP

20100055777 - Tissue processor: A tissue processor is described that comprises a retort for processing histological samples using various reagents, a plurality of exchangeable reagent supply containers that each comprise at least one container opening, a system of conduits, a control device for conveying reagents out of the reagent supply containers through at least... Agent: Alexander R Schlee SchleeIPInternational P.C.

20100055779 - Cell culture vessel, production process thereof and cultured cell: An object of the present invention is to provide a cell culture vessel which is simple in structure and easy to handle, and is capable of preventing damage to the cells when separated, promoting transport of nutrients and excretion of effete matter, and elevating the culturing efficiency improving effect by... Agent: Antonelli, Terry, Stout & Kraus, LLP

20100055778 - Mammalian zcytor 11: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in pancreas, small intestine, colon and thymus. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation... Agent: Darby/zymogenetics, Inc.

20100055780 - Targeted nucleotide exchange with propynyl modified oligonucleotides: A method and oligonucleotides for targeted nucleotide exchange of a duplex DNA sequence, wherein the donor oligonucleotide contains at least one modified nucleotide which is a propynylated purine and/or pyrimidine having a higher binding affinity compared to naturally occurring A, C, T or G and/or binds stronger to a nucleotide... Agent: Foley And Lardner LLP Suite 500

20100055785 - Endogenous expression of hla-g and/or hla-e by mesenchymal cells: Methods and compositions are provided for the identification and isolation of mammalian HLA-G+ MSC, HLA-E+ MSC, or HLA-G4VHLA-E+ MSC. The methods of the invention provide a means to obtain enriched HLA-G+ MSC, HLA-E+ MSC, or HLA-G+/HLA-E+ MSC populations.... Agent: Wilmerhale/boston

20100055782 - Nucleic acid compounds for inhibiting myc gene expression and uses thereof: The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing MYC gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-over-lapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.

20100055783 - Nucleic acid compounds for inhibiting ras gene expression and uses thereof: The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing RAS (e.g., HRAS, KRAS, NRAS) gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.

20100055784 - Nucleic acid compounds for inhibiting wnt gene expression and uses thereof: The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing WNT1, WNT2, or WNT3A gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.

20100055781 - Substrate for culture of cardiovascular tissue: The scaffold for culturing a cardiovascular tissue of the present invention is a scaffold for culturing a cardiovascular tissue, which is tubular, and comprises a foamed polymer comprising a bioabsorbable material reinforced with a reinforcing material comprising a bioabsorbable material, the foamed polymer comprising lactide (D, L, DL isomer)-ε-caprolactone copolymer... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100055786 - Method for treating kidney disorders: The present invention relates to a method for treating, delaying and/or preventing renal dysfunction/failure in a mammal comprising administering a therapeutically effective amount of a substance capable of inducing and/or enhancing Pax2 expression. Furthermore, the invention relates to the use of an effective dose of a substance capable of inducing... Agent: Foley And Lardner LLP Suite 500

20100055787 - In-vitro pearl production using marine organisms: This invention in general relates to the production of pearls using marine organisms. More particularly, the present invention relates to in-vitro pearl production wherein shape, size and colour of the pearl can be controlled. A semi solid medium is used in the present invention which facilitates the bead to stand... Agent: Harness, Dickey, & Pierce, P.l.c

20100055788 - Method and apparatus for infiltrating tissue samples with paraffin: A method and an apparatus are described for infiltrating tissue samples with carrier material, preferably paraffin. A supply of carrier material is kept ready for use in a supply station. From there, the carrier material can be delivered into at least a first and a second container. In these first... Agent: Alexander R Schlee SchleeIPInternational P.C.

20100055789 - Method and apparatus for the stimulation of hair growth: A method for activating or inhibiting the differentiation of stem cells including exposing the stem cells to a source of narrowband multi chromatic electromagnetic radiation under conditions effective to activate or inhibit cell differentiation.... Agent: Nelson Mullins Riley & Scarborough LLPIPDepartment

20100055790 - Cell culture apparatus and associated methods: A cell culture apparatus consists of a vessel or array of vessels, each comprising a substantially flat bottom and substantially vertical sides, and composed of a substantially gas permeable material. The inner bottom surface of the vessel is commonly textured to provide the cells with adequate features for attachment and... Agent: Eric M. Simon

20100055791 - Matrix for regenerating cardiovascular tissue and method for regenerating cardiovascular tissue: Materials for culturing cardiovascular tissues wherein a sponge made of a bioabsorbable material is reinforced with a reinforcement made of a bioabsorbable material.... Agent: Knobbe Martens Olson & Bear LLP

20100055792 - Ex vivo generated tissue system: The present invention relates to methods of generating an ex vivo tissue-like system in a bioreactor system capable of supporting continuous production of, and output of cells and tissues and an ex vivo tissue system made therefrom.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100055793 - Site-specific modification of the human genome using custom-designed zinc finger nucleases: Disclosed herein are chimeric zinc finger endonucleases useful in disrupting and/or replacing at least a portion of a gene of interest (e.g. CFTR, DMPK, CCR5, TYR or βglobin).... Agent: Venable LLP

20100055794 - Selection of cells expressing heteromeric polypeptides: This invention is in the general field of recombinant expression of polypeptides in animal cell culture. More particularly, the invention concerns improved selection in cells of recombinantly engineered vectors designed to express polypeptides.... Agent: Immunex Corporation

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