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Chemistry: molecular biology and microbiology February patent applications/inventions, industry category 02/10

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
02/25/2010 > patent applications in patent subcategories. patent applications/inventions, industry category

20100047761 - Capillary transport: A method for sorting particles, in particular cells A and B. The method uses a single channel with only one input and only one output. A particle mix A and B in a fluid is introduced into the channel and particles within the channel are sorted.... Agent: Alston & Bird LLP

20100047762 - Method to monitor drug efficacy in diabetic patients using an assay for 1,5-anhydro-d-glucitol: HbA1c measurement is a critical component of diabetes management; however, a key limitation of HbA1c as a measure of glycemia is the lack of timeliness—it does not detect underlying blood glucose excursion levels in moderately controlled diabetic patients (HbA1c<8) as it is a measurement of mean glucose levels over the... Agent: Darby & Darby P.C.

20100047768 - Amplification of single viral genomes: The present invention relates, e.g., to a method for amplifying the genome of a single virus particle from a mixture of virus particles, comprising (a) subjecting the mixture of virus particles to flow cytometry and identifying a sorted sample that putatively contains a single virus particle, (b) imbedding the sorted... Agent: Venable LLP

20100047766 - Analyte manipulation and detection: wherein each different particle has, or can be controlled to have, a different buoyancy in the fluid as compared with the other particles; and wherein the separating conduit is in fluid communication with the two or more functional conduits, each functional conduit being situated at a different height from the... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100047765 - Molecular determinants associated with enhanced ability to enter cells expressing cxcr4: The invention provides a method for determining whether a human immunodeficiency virus is likely to be have enhanced ability to enter a cell expressing CD4 and CXCR4 relative to a reference HIV. In certain aspects, the methods comprise detecting one or more amino acid in an envelope protein of the... Agent: Jones Day

20100047764 - Novel surface protein (hbsag) variant of the hepatitis b virus: The invention relates to sequences of a novel variant of the Hepatitis B surface antigen (HBsAg) and to methods for detecting, in patient samples, nucleic acids, antigens, and antibodies directed against the same.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100047767 - Pathogen binding: Provided is a method for determining the presence or absence of a pathogen in a sample, which method comprises: a) contacting the sample with a whole or a part of a cell surface receptor protein capable of binding the pathogen; b) allowing the cell surface receptor protein or part thereof... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100047763 - Plasmid expression vectors for expression of recombinant rotavirus and astrovirus proteins or epitopes: The present invention refers to the production of specific recombinant viral proteins intended for use in the construction of a diagnostic kit for the simultaneous detection of the two most important gastroenteric viruses, namely rotavirus and astrovirus.... Agent: Merek, Blackmon & Voorhees, LLC

20100047798 - Adenosine a1 and a3 receptor gene sequence variations for predicting disease outcome and treatment outcome: The present invention relates to methods for identify subjects for responsiveness to adenosine agonist treatment. Another aspect of the present invention relates to methods to predict a relative infarct size in response to ischemia reperfusion injury. In particular, the present invention relates to methods for to identify responsiveness to adenosine... Agent: David S. Resnick

20100047782 - Assessment of risk for colorectal cancer: Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20100047779 - Biomarkers: The present invention provides circulating biomarkers for conditions associated with metabolic syndrome, including diabetes mellitus, hypertension and congestive heart failure. The biomarkers include plasma DNA, neuron-specific enolase, 11β-hydroxysteroid dehydrogenase, rhodopsin, retinoschisin, RPE65 and cardiac troponin T. Methods and kits for detecting these biomarkers in the prediction, monitoring and diagnosing of... Agent: Morgan Lewis & Bockius LLP

20100047803 - Biomarkers for acetaminophen toxicity: Materials and methods for evaluating cellular responses to acetaminophen and assessing susceptibility to liver damage.... Agent: Fish & Richardson P.C.

20100047774 - Cartridge, system and method for automated medical diagnostics: Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed... Agent: Philips Intellectual Property & Standards

20100047776 - Cell-based screening assays for compounds that regulate the expresion of a tumor marker dj-1: The present invention generally provides compositions and methods that are useful for the treatment or prevention of a neoplasm, and screening methods that can be used to detect compounds that modulate the activity of a DJ-I gene.... Agent: Edwards Angell Palmer & Dodge LLP

20100047810 - Compositions and methods for treating diseases associated with t-box and n-myc: The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene, which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells,... Agent: Dla Piper LLP (us)

20100047772 - Compounds, compositions and methods for the treatment of diseases characterized by a-33 related antigens: The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing such antigens PRO301, PRO362 or PRO245.... Agent: Arnold & Porter LLP (24126) Attn:IPDocketing Dept.

20100047797 - Cytolethal distending toxins and detection of campylobacter bacteria using the same as a target: The present inventors succeeded in cloning the CDT genes of C. coli and C. fetus, which were previously unknown, and in determining their sequences. In addition, the inventors also developed specific primers and primers common to the two species by comparing the CDTs of C. jejuni and C. fetus. Furthermore,... Agent: Bozicevic, Field & Francis LLP

20100047770 - Detection of breast cancer: A method for the detection of the presence or risk of cancer in a patient, comprises the steps of: (i) isolating a sample of the patient's genome; and (ii) detecting the presence or expression of the gene characterized by any of the nucleotide sequences identified as SEQ ID No 1,... Agent: Marshall, Gerstein & Borun LLP

20100047808 - Device and method for extraction and analysis of nucleic acids from biological samples: Device and methods for extracting and analyzing nucleic acids from biological samples.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20100047786 - Dna-based test for detection of annual and intermediate ryegrass: We have developed a novel TaqMan quantitative PCR (Q-PCR) based DNA test for detecting annual and/or intermediate ryegrass types in perennial ryegrass. This DNA test was designed using an insertion/deletion (InDel) site in the LpVRN2_2 gene. The new DNA test is more reliable, accurate, and cost effective in detecting annual... Agent: Wm. Larry Alexander, Attorney At Law P.A.

20100047807 - Genetic variants associated with periodic limb movements and restless legs syndrome: The present inventions discloses genetic markers and haplotypes that have been found to be associated with risk of Restless Legs Syndrome (RLS), Periodic Limb Movement Disorder (PLMD), and Periodic Limb Movements of Sleep (PLMS). Methods for determination of susceptibility of these disorders are disclosed using such markers, as are kits... Agent: Marshall, Gerstein & Borun LLP

20100047792 - Label-free optical detection method: The present provides optical sensor based sensitive, label-free binding assay methods and kits for isothermal real-time detection of the binding of specific analytes (such as nucleic acids, proteins and low molecular weight antigenic or receptor binding ligands) present in low amount in different biological samples. In the binding assays of... Agent: Szendro Islvan

20100047771 - Markers for the diagnosis of lung cancer: Disclosed is a diagnostic marker specific for lung cancer. Also, the present invention relates to a composition and a kit, comprising an agent measuring the presence of the marker, and a method of diagnosing lung cancer using the composition or kit.... Agent: Jhk Law

20100047788 - Method and kit for diagnosis and monitoring of the treatment of chronic tripanossomiasis and chagas disease: s

20100047801 - Method and system for data driven management of individual seeds: A method for managing seed includes non-destructively sampling individual seeds to assist in providing evaluation data for each of the individual seeds, storing the evaluation data and seed identifiers associated with each of the individual seeds in a data store, selecting a subset of seed for planting at least partially... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pioneer Hi-bred

20100047784 - Method for detecting nucleic acids: Described herein are methods and compositions for detecting, amplifying and labeling targeted nucleic acids, including microRNAs.... Agent: Foley And Lardner LLP Suite 500

20100047794 - Method for discriminating between nucleotide sequences of nucleic acids: It is an object of the present invention to provide a method for discriminating between nucleic acid sequences with high accuracy by utilizing a method for specifically amplifying nucleic acid sequences under isothermal conditions. The present invention provides a method for discriminating between the nucleotide sequence of a first nucleic... Agent: Birch Stewart Kolasch & Birch

20100047775 - Method of identifying individuals at risk of perioperative myocardial injury, major adverse cardiac events, cognitive decline, arrhythmias, depression or bleeding: The present invention relates to methods of identifying individuals at risk of perioperative myocardial injury, major adverse cardiac events, cognitive decline, arrhythmias, depression and bleeding.... Agent: Nixon & Vanderhye, PC

20100047789 - Method of surface plasmon resonance (spr) to detect genomic disorders for postnatal diagnosis: The present invention discloses using SPR technology to postnatally detect specific DNA loss or gain related to some genomic disorders. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of... Agent: Weili Cheng

20100047805 - Methods and compositions for targeted single-stranded cleavage and targeted integration: Disclosed herein are methods and compositions for generating a single-stranded break in a target sequence, which facilitates targeted integration of one or more exogenous sequences.... Agent: Robins & Pasternak

20100047804 - Methods for distinguishing between lung squamous carcinoma and other non small cell lung cancers: The present invention provides nucleic acid sequences that are used for identification, classification and diagnosis of specific types of nonsmall-cell lung cancers (NSCLC). The nucleic acid sequences can also be used for prognosis evaluation of a subject based on the expression pattern of a biological sample.... Agent: Foley And Lardner LLP Suite 500

20100047777 - Methods for identifying mutations in coding and non-coding dna: The present invention provides methods of identifying mutations in nucleic acid. Also provided herein are methods of identifying subjects having Hirschsprung disease risk and diagnostic markers for Hirschsprung disease.... Agent: Edwards Angell Palmer & Dodge LLP

20100047793 - Methods to stimulate biogenic methane production from hydrocarbon-bearing formations: The present invention describes methods of identifying stimulants for the biogenic production of methane in hydrocarbon-bearing formations. Methods involve the use of microbial nucleic acid sequence information for the determination of gene products that are enzymes in a variety of pathways involved in the conversion of hydrocarbons to methane. Enzymes... Agent: Synthetic Genomics C/o Mofo

20100047778 - Methylation specific primer extension assay for the detection of genomic imprinting disorders: Provided is a method for determining genomic imprinting disorders in a patient based upon methylation specific primer extension in a format amenable to high throughput and multiplex formats. After bisulfite modification of a genomic sample, DNA is amplified and hybridized to discrimination primers specific for a CpG dinucleotide site in... Agent: Siemens Corporation Intellectual Property Department

20100047791 - Molecular accessibility assay: Methods and compositions are provided for determining polypeptide-nucleic acid interactions.... Agent: Wolf Greenfield & Sacks, P.C.

20100047773 - Novel circle probes and their use in the identification of biomolecules: The present invention provides oligonucleotides and methods for efficient detection of target nucleic acids using rolling circle replication. In one aspect, the oligonucleotides of the invention are characteristic in that they can be circularised without an external ligation template. In another aspect, the oligonucleotides of the invention are characteristic in... Agent: Sunstein Kann Murphy & Timbers LLP

20100047769 - Novel protein having an egf-like repeat sequence: The present invention provides SELF protein having controlling effects on growth and differentiation of undifferentiated cells, wherein the protein contains a novel EGF-like repeat sequence, SELF gene encoding the same, a recombinant vector and a transformed cell containing the SELF gene, a method for treatment or prophylaxis with SELF protein... Agent: Birch Stewart Kolasch & Birch

20100047802 - Nucleic acid synthesis compositions and methods and systems for using same: The Application relates to compositions, kits, methods, and systems for nucleotide sequencing comprising producing polymerase reactions that comprise both catalytic and non-catalytic divalent metal ions. Effective ratios and amounts of catalytic and non-catalytic divalent metal ions are described.... Agent: Pacific Biosciences Of California, Inc.

20100047809 - Pca3, pca3 genes, and methods of use: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins... Agent: Goudreau Gage Dubuc

20100047785 - Pkd mutations and evaluation of same: The present invention relates to methods of detecting novel mutations in a PKD1 and/or PKD2 gene that have been determined to be associated with autosomal dominant polycystic kidney disease (ADPKD) in order to detect or predict the occurrence of ADPKD in an individual.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100047781 - Primer set for detection of dekkera yeast or brettanomyces yeast: An object of the present invention is to provide a primer set for use in a LAMP method, which can accurately, rapidly and simply identify yeast species of genus Dekkera and yeast species of genus Brettanomyces. According to the present invention, there is provided a LAMP primer set for use... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100047806 - Probes for detecting immune-related gene polymorphisms and applications of the same: Polymorphism detection probes that can distinguish polymorphisms that have only one different base are provided. At least one oligonucleotide selected from the group consisting of the oligonucleotides of SEQ ID NOS. 4, 23, 30, 47, 57 and 64 is used as a probe in a Tm analysis. A Tm analysis... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100047795 - Promoter variants of the alpha-7 nicotinic acetylcholine receptor: The present invention is directed to methods and compositions related to α7 acetylcholine nicotinic receptor genes, in particular, the human α7 nicotinic acetylcholine receptor gene. The human α7 nicotinic acetylcholine receptor gene is associated with the pathophysiological aspects of the disease schizophrenia. The present invention further provides methods and compositions... Agent: Peter G. Carroll Medlen & Carroll, LLP

20100047787 - Prostate cancer survival and recurrence: The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to prostate cancer. In particular, the disclosure is based on the identities of genes that are correlated with patient survival and prostate cancer recurrence. The gene expression profiles may be embodied in nucleic acid... Agent: Patentique PLLC

20100047800 - Reagents and methods for detecting cyp2c9 polymorphisms: The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the specific detection of clinically relevant CYP2C9 polymorphisms, in particular CYP2C9 polymorphisms associated with adverse drug response. The oligonucleotide sequences are also provided assembled as kits that can... Agent: Siemens Corporation Intellectual Property Department

20100047796 - Reversible terminator nucleotides and methods of use: Disclosed herein a reversible terminator nucleotides and methods of use.... Agent: Life Technologies Corporation C/o Intellevate

20100047790 - Sample analyser: There are provided processes for analysing a plurality of different samples. The processes comprise the steps of: a) applying the samples to a support, to which an analytical component is immobilised; and b) allowing the samples to interact with the analytical component, thus permitting analysis of the samples. The samples... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100047783 - Small molecule modulators of p53 family signaling: This invention relates to methods for identifying compound capable of activating p53-responsive transcriptional activity in a p53-deficient tumor cell and the use of these compounds.... Agent: Pearl Cohen Zedek Latzer, LLP

20100047780 - Target and method for inhibition of bacterial rna polymerase: Target and method for inhibition of bacterial RNA polymerase disclosed are targets and methods for specific binding and inhibition of RNAP from bacterial species.... Agent: Hoffmann & Baron, LLP

20100047799 - Urinary immunochromatographic multiparameter detection cup: The present invention refers to an immuno-chromatographic detection cup and its use for simultaneously detecting at least one antigen, e.g. tuberculosis antigen, malaria antigen and pneumonia antigen, and at least one antibody, e.g. HIV antibody, HCV antibody and H. pylori antibody, in a urine sample. The urinary detection cup comprises... Agent: Patent Central LLC Stephan A. Pendorf

20100047813 - Bioluminescence resonance energy transfer (bret) systems and methods of use thereof: Briefly described, embodiments of this disclosure include bioluminescence resonance energy transfer (BRET) systems, methods of detecting a protein-protein interaction, noninvasive methods for detecting the interaction of a first protein with a second protein within a living animal, methods to determine the efficacy of a test compound administered to modulate the... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20100047821 - Crown ether derivatives: The invention describes crown ether chelators, including crown ethers having the formula:... Agent: Life Technologies Corporation C/o Intellevate

20100047820 - Detecting method, detecting apparatus, detection sample cell, and detecting kit: A sample is supplied onto the sensor portion of a sensor chip. An excitation light beam is irradiated to generate an enhanced optical field to be generated on the sensor portion. Fluorescent labels are excited, and the amount of a detection target substance is detected, based on the amount of... Agent: Sughrue Mion, PLLC

20100047818 - Diagnosis of carcinomas: The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also... Agent: Duane Morris LLP - PhiladelphiaIPDepartment

20100047811 - Method for optimizing the automatic fluorescence pattern recognition in immunodagnosis: The invention relates to a method for optimizing the automatic fluorescence pattern recognition in immunodiagnosis. In this method, in addition to or together with the fluorescence dye, one or more other indicator dyes for the identification of relevant structures are incubated before an image is taken with a camera.... Agent: Hovey Williams LLP

20100047815 - Method to detect tumor markers and diagnosis of undifferentiated tumors: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different tumor markers in a protein sample extracted from tumor tissue, which can be used for the diagnosis of undifferentiated tumors. It also discloses an efficient formula to make a mixed SAM that can greatly enhance... Agent: Weili Cheng

20100047819 - Multiplex assay for rheumatoid arthritis: Multiplex assays that allow for the detection and quantification of Rheumatoid Factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies in a single reaction mixture are provided.... Agent: Townsend And Townsend And Crew, LLP

20100047812 - Peptide antibody depletion and its application to mass spectrometry sample preparation: The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant and/or well-ionizing and/or proteotypic peptides from the sample. Also described are methods for identifying well-ionizing peptides for use in this and other... Agent: Venable LLP

20100047814 - Protein interaction reporter agents and methods for using same: Particular aspects provide novel protein interaction reporter (PIR) compounds (e.g., formulas I and II), comprising at least two protein reactive moieties (e.g., N-hydroxysuccinamide), each linked to a reporter moiety (e.g., mass reporter) by a covalent labile bond that is differentially cleavable with respect to peptide bonds (e.g., by a method... Agent: Davis Wright Tremaine, LLP/seattle

20100047816 - Rapid immunochromatographic detection by amplification of the colloidal gold signal: The present invention relates to a rapid immunochromatographic test device suitable to detect an antibody and/or antigen in at least one sample, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the device.... Agent: Patent Central LLC Stephan A. Pendorf

20100047817 - Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100047822 - Timp-4 as a biomarker for the diagnosis of cardiac insufficiency: The invention relates to the use of the plasma concentration of the polypeptide “tissue inhibitor of metalloproteinase-4” (TIMP-4) as a biomarker for the diagnosis of heart failure.... Agent: Barbara A. Shimei Director, Patents & Licensing

20100047823 - Polypeptides: The use of polypeptides capable of binding to PtdIns(3,4)P2, PtdIns3P, PtdIns4P or but not capable of binding to PtdIns(3,4,5)P3, in a screening method for identifying a compound suitable for modulating signalling by PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The polypeptides preferably comprises a PH (pleckstrin homology) domain which binds specifically to... Agent: Knobbe Martens Olson & Bear LLP

20100047826 - Cell into which protein, which can serve as polymerization nucleus of protein polymer, or polymer thereof is introduced, and method for production of the cell: The present invention has the object of providing a cell into which a protein, which can serve as a polymerization nucleus of a protein polymer, or polymer thereof is introduced, and a method for producing the cell. The invention relates to a cell into which a protein, which can serve... Agent: Birch Stewart Kolasch & Birch

20100047827 - Novel specific cell binders: The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins... Agent: Birch Stewart Kolasch & Birch

20100047824 - Citrus fruit peeling process: An efficient process for enzymatically peeling citrus fruit applies a vacuum to perforated fruit and, while maintaining that vacuum, introduces an enzyme solution to the perforated fruit. The fruit is infused with the enzyme by releasing the vacuum pressure. After incubating the enzyme, the albedo of the fruit is weakened... Agent: Buchanan, Ingersoll & Rooney PC

20100047828 - Solid-phase detection of terminal monosaccharides cleaved from glycosylated substrates: The present invention relates to a novel method for analysing carbohydrates. The invention is in particular useful in detecting a terminal monosaccharide which may be released from a glycosylated substrate for example using an exoglucosidase. After relase from the glycosylated substrate the terminal monosaccharide may be captured on a solid... Agent: Millen, White, Zelano & Branigan, P.C.

20100047825 - Immunoassay reagents and methods of use thereof: The present invention provide reagents and methods of using the reagents, for example, on automated staining devices, that facilitate detection of two or more antigens in a sample simply and efficiently.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100047829 - Activated her3 as a marker for predicting therapeutic efficacy: The present invention provides methods for the determination of the activation level of Receptor Tyrosine kinases, e.g. phosporylated HER3, for the selection of patients for disease treatment. Methods are also provided for the evaluation of the biological and pharmacodynamic effects of an active substance and/or its efficacy in disease treatment,... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100047830 - Compositions and methods for detecting cancers in a subject: Disclosed are compositions and methods for detecting oral and gastrointestinal cancers in a subject. Autoantigen p90 was shown to be overexpressed in oral cancer cells, and this protein, as well as its companion autoantigen p62 and antibodies directed to both proteins, can be used as markers for detecting oral digestive... Agent: Gregory A. Nelson Novak Druce & Quigg LLP

20100047831 - Diagnosis of anthrax infection by detection of capsular antigen in urine: The present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum, urine, or other biological samples.... Agent: Nixon Peabody, LLP

20100047832 - Assessment of patients with sepsis to determine a requirement for therapeutic intervention with an anti-inflammatory and/or anticoagulatory agent: Methods of selecting patients with sepsis for treatment with an anti-inflammatory and/or anticoagulatory agent are provided.... Agent: Licata & Tyrrell P.C.

20100047833 - Diagnostic method for the determination of helicobacter pylori: The present invention relates to a diagnostic method for the determination of Helicobacter pylori in a tissue biopsy comprising the step of incubating a tissue biopsy with an aqueous diagnostic reagent comprising urea and a pH indicator, and determining any pH change, characterised in that said diagnostic reagent comprises a... Agent: Steinfl & Bruno

20100047834 - Method for stabilizing alpha-thrombin in thrombin-containing solution: To provide a method for stabilizing unstable α-thrombin in a thrombin-containing solution, a solution containing stabilized α-thrombin, and a liquid fibrinogen assay reagent containing the solution. The method for stabilizing α-thrombin in a thrombin-containing solution, which includes adjusting the percentage of α-thrombin to 70% or more with respect to the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100047835 - Diagnosis of infections or inflammatory diseases of the airways and lungs associated with heart failure: The invention relates to a method for diagnosis of infections or inflammatory diseases of the airways and lungs with associated heart failure, wherein the marker procalcitonin or a partial sequence thereof is determined in a patient to be examined, in particular for classifying patients according to risk. The invention further... Agent: Connolly Bove Lodge & Hutz, LLP

20100047836 - Lipolytic enzyme variants: Molecular dynamics (MD) simulation on the three-dimensional structure of Candida anrtarctica lipase B revealed two hitherto unknown lids with a marked mobility, and this discovery was used to design lipolytic enzyme variants with increased lipolytic enzyme activity.... Agent: Novozymes North America, Inc.

20100047837 - Method for the early detection of renal injury: A method and kit for detecting the immediate or early onset of renal disease and injury, including renal tubular cell injury, utilizing NGAL as an immediate or early on-set biomarker in a sample of blood serum. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected... Agent: Hasse & Nesbitt LLC

20100047838 - Yeast genes that affect viral replication: An antiviral agent comprising an altered MAB1, MAB2, MAB3, or OLE1 gene, gene homologs or related genes is disclosed. In another embodiment, the present invention is a method of creating a virus resistant organism comprising creating a transgenic organism comprising an antiviral agent selected from the group of altered MAB1... Agent: Quarles & Brady LLP

20100047839 - Latent fluorimetric indicator for biological analytes determination and the preparation method thereof: The present invention provides a sensitive fluorimetric indicator for analytes determination in the oxygen-insensitive DT-diaphorase-coupled dehydrogenases assay by omitting NADH, which is generated by reaction in the presence of analytes, which presents to the applicability as a biosensor for future clinical diagnostic. Furthermore, the novel long-wavelength latent fluorimetric indicator is... Agent: Schmeiser, Olsen & Watts

20100047848 - Colorimetric determination of somatic cell count in milk: A simple calorimetric in-line quantitative test to measure white blood cell counts in milk samples using a liquid reagent system that simplifies quantitative in-line SCC measurements using a reflectance measuring mode, and a new apparatus, which permits in-line colorimetric analysis.... Agent: Donald C. Simpson, Esq.

20100047843 - Compositions and methods for enhancing the growth of mouse embryonic stem cells: Compositions and methods are provided which improve the growth rate, self-renewal potential and capacity of germ line transmission of mouse embryonic stem cells.... Agent: Dann, Dorfman, Herrell & Skillman

20100047849 - Determination of testosterone by mass spectrometry: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present... Agent: Foley & Lardner LLP

20100047844 - Diagnostic marker for fabry disease: The present invention is in the field of Fabry disease and concerns a pathogenic factor allowing diagnosis of Fabry disease. In particular lyso-ceramide trihexosamide (lyso-CTH) has been found to function as a diagnostic marker for Fabry disease.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100047846 - Endogenous and non-endogenous versions of human g protein-coupled receptors: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown (“orphan GPCR receptors”), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.... Agent: Arena Pharmaceuticals, Inc. Bozicevic, Field & Francis LLP

20100047845 - Method of reducing curvature in a meniscus of liquid medium: The present application is directed to methods of improving cell culture vessel assays. In one aspect the application is directed to a method of reducing the curvature of the meniscus comprising applying a coating material to the interior wall of the vessel, wherein the coating material provides a receding contact... Agent: Fulbright & Jaworski L.L.P.

20100047847 - Methods for diagnosing ovarian cancer: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition.... Agent: Edwards Angell Palmer & Dodge LLP

20100047842 - Novel toxicity assay based on human blastocyst-derived stem cells and progenitor cells: An in vitro toxicity assay based on human blastocyst-derived stem cells for the detection of toxicity in the human species is provided, which enables novel detection of in vitro human toxicity for a substance and/or more efficiently detects human toxicity compared to non-human assays. Furthermore, the detection of toxicity for... Agent: Buchanan, Ingersoll & Rooney PC

20100047840 - Polypeptide markers for the diagnosis of bladder cancer: A method for the diagnosis of bladder cancer (BC) and/or for determining a tumor stage of bladder cancer, comprising the step of determining the presence or absence or amplitude of at least six polypeptide markers in a sample, wherein said polypeptide markers are selected from markers 1 to 836, which... Agent: Ohlandt, Greeley, Ruggiero & Perle, LLP

20100047841 - Synthesis of desacetoxytubulysin h and analogs thereof: m

20100047850 - Method and device for rapid detection of microorganisms by changing the shape of micro-colonies in micro-channels: This invention describes a method of rapid detection of micro-colonies of microorganisms by changing their shape from a regular semi-sphere to a long and thin cylinder. Cells are trapped by filtration in long (diameter/length=1/10-1/100), cylindrical, parallel, micro-channels that are open from both sides, and attached to a filter from one... Agent: Nanologix, Inc.

20100047853 - Ex vivo culture, proliferation and expansion of intestinal epithelium: Methods are provided for long term culture of mammalian intestinal cells. Cultures are initiated with fragments of mammalian intestinal tissue, which are then maintained embedded in a gel substrate that provides an air-liquid interface. Intestinal epithelium in cultures of the invention can be continuously grown for extended periods of time.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20100047851 - Methods and compositions for the detection of microbial contaminants: The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial... Agent: Goodwin Procter LLP Patent Administrator

20100047852 - Selective culture medium: The present invention discloses a selective culture medium for detecting MRSA and selective drug or multidrug resistant microorganisms where the expression of said (multi)drug resistance is by virtue of the production by said microorganisms of β-lactamase enzymes. The medium comprises: (i) a broad spectrum antibiotic capable of selectively inhibiting growth/replication... Agent: Knobbe Martens Olson & Bear LLP

20100047856 - Bacteria analyzer, bacteria analyzing method and computer program product: The present invention is to present a bacteria analyzer comprising: a detector comprising: a light source for irradiating light on a measurement sample prepared from a specimen and a reagent; and a light receiving unit for receiving light generated by irradiating the light on the measurement sample from the light... Agent: Brinks Hofer Gilson & Lione

20100047858 - High throughput system for cfu assay by the use of high resolution digital imaging, differential staining and automated laboratory system: Disclosed herein is a high throughput system for the objective, standardized determination of colony forming units in populations of hematopoietic cells and indication of successful engraftment. Further disclosed is a laboratory information management system that provides electronic storage of images and data associated with cord blood units.... Agent: K&l Gates LLP

20100047854 - Method for detection of human precursor t cell and precursor b cell: A method for detection of a precursor T cell or precursor B cell, a method for evaluation of the property of a hematopoietic precursor cell in a source for transplantation, and a kit for use in the evaluation are disclosed. A precursor T cell or precursor B cell can be... Agent: Young & Thompson

20100047855 - Method for determining the quantity of microbiological objects during cultivation thereof: A method for determining the quantity of microbiological objects during the cultivation thereof comprises determining a modification of studied microorganism cells' population, measuring the morphological composition thereof by determining the cells' size distribution in a liquid medium according to intensity changes of the light dispersed thereby. The method comprises probing... Agent: Aleksandr Smushkovich

20100047857 - Multiple analyte immunoassay: Methods for measuring the amount of two or more analytes of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods involve determining a ratio of a detected amount of a single analyte of interest, to the sum of a detected amount of each of... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100047859 - Silica-based fluorescent nanoparticles: A composition including the reaction product of: an organic silane of Formula SiR1mX14-m; a fluorescent dye-silane compound of Formula D-L′-(CH2)n—SiX23; water; and a hydrolysis catalyst; where R1 is a C1-C6 alkyl that is unsubstituted or substituted with one or more halogens or hydroxyl group, C2-C6 alkenyl that is unsubstituted or... Agent: Edwards Angell Palmer & Dodge LLP

20100047860 - Device for storing specimen slice and instrument for microscopic observation provided with the same: [Means for Solving Problems] A device comprising: a piece of a resin film on which a slice having been excised from a sample block or a cell block slice is adhered and fixed via an adhesive layer provided on the surface thereof; and a holder on the surface of which... Agent: Snell & Wilmer L.L.P. (main)

20100047863 - Group of novel enantiosleective microbial nitrile hydratases with broad substrate specificity: The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E.C. 4.2.1.84] activity. Furthermore, a vector and a host comprising the disclosed polynucleotide or pair of polynucleotides and methods for the production of the same are provided. Moreover, the invention relates to... Agent: Pillsbury Winthrop Shaw Pittman LLP

20100047866 - Heat-stable carbonic anhydrases and their use: The present invention relates to use of heat-stable carbonic anhydrase in CO2 extraction, e.g., from flue gas, natural gas or biogas. Furthermore, the invention relates to isolated polypeptides having carbonic anhydrase activity at elevated temperatures and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors,... Agent: Novozymes North America, Inc.

20100047867 - Il-1 zeta, il-1 zeta splice variants and xrec2 dnas and polypeptides: The invention is directed to novel, purified and isolated IL-1 zeta and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and uses thereof.... Agent: Immunex Corporation

20100047862 - Novel dna polymerase: This invention provides a novel DNA polymerase obtained from Bacillus smithii JCM9076, which has novel features in terms of, for example, optimal reaction conditions (e.g., optimal temperature) and enzyme activity. More particularly, a novel DNA polymerase is a pol I type DNA polymerase, which is any of proteins (a) to... Agent: Birch Stewart Kolasch & Birch

20100047869 - Novel thermophilic endo-glucanase and uses thereof: A novel thermophilic endo-glucanase, nucleic acid encoding the endo-glucase, and uses thereof in converting lignocellulosic material to fermentable sugars.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100047861 - Process for producing useful substance: The present invention provides processes of producing useful substances, which include the steps of culturing in a medium microorganisms that lack from their chromosomal DNA all or part of a gene encoding a protein having the amino acid sequence shown in SEQ ID NO: 1 or a gene encoding a... Agent: Townsend And Townsend And Crew, LLP

20100047864 - Process for the production of recombinant proteins using carnivorous plants: The present application relates to the provision of process for producing at least one protein, comprising the cultivation of a carnivorous plant, characterized in that said plant has been genetically modified to express said protein or proteins, and said protein or proteins are collected from the digestive secretions of said... Agent: Foley And Lardner LLP Suite 500

20100047868 - Tumour suppressor protein: We describe a polypeptide which binds and modulates the activity of a tumour suppressor polypeptide, for example p53; a nucleic acid molecule encoding said protein and screening methods which modulate the binding activity of said polypeptide for its target polypeptide(s).... Agent: Marshall, Gerstein & Borun LLP

20100047865 - Vector for expressing nc protein of hiv and method for producing nc protein using the same: The present invention relates to a vector for expressing an NC protein of HIV and a method for producing an NC protein using the same. More particularly, the present invention relates to a vector for expressing an NC protein of HIV, in which an intron sequence and an mRNA stability... Agent: Edwards Angell Palmer & Dodge LLP

20100047870 - Low cell density fermentation process for the production of heterologous recombinant proteins in microorganisms: A low cell density fermentation process for the production of heterologous proteins in microorganisms. The cell culture obtained by cultivating host microorganisms transformed with a vector carrying genetic material for the said proteins and an inducible promoter under batch fermentation conditions is fed with a feed medium after an OD600... Agent: Sughrue Mion, PLLC

20100047871 - Fusion proteins of hiv regulatory/accessory proteins: The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins... Agent: Law Office Of Salvatore Arrigo

20100047872 - Process for producing useful substance: The present invention provides a process for producing a useful substance by use of a microorganism that lacks in their chromosomal DNA all or part of a gene encoding a protein having the amino acid sequence shown in SEQ ID NO: 1 or a gene encoding a protein having 80%... Agent: Townsend And Townsend And Crew, LLP

20100047873 - Process for the production of daptomycin: The present invention relates to an improved process for the production of Daptomycin by fermentation with Streptomyces roseosporus, in the presence of n-decanal or Cuphea oil as sources of the n-decanoyl side chain. These reagents allow to reduce toxicity effects on the bacteria and to avoid the use of solvents... Agent: Arent Fox LLP

20100047874 - Purine-derived substance-producing bacterium and a method for producing a purine-derived substance: A purine-derived substance is produced by culturing a bacterium belonging to the genus Bacillus which has an ability to produce a purine-derived substance and has been modified so that enzymatic activity of transaldolase is decreased in a medium to cause accumulation of a purine-derived substance in the medium or cells,... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100047875 - Making nucleic acid sequences in parallel and use: The present invention relates generally to the fields of genomics, synthetic biology and genetic engineering. More particularly, the present invention concerns the methods that enable parallel multiplex ligation and amplification on surface for making assemblies of nucleic acids of various biological applications and for analysis of biological samples such as... Agent: G. Kenneth Smith

20100047876 - Hierarchical assembly of polynucleotides: Methods, compositions and apparatuses for hierarchical assembly of oligonucleotide sequences are provided.... Agent: Banner & Witcoff, Ltd.

20100047877 - Novel phospholipases and uses thereof: The invention relates to a newly identified polynucleotide sequence comprising a gene that encodes a novel phospholipase isolated from Aspergillus niger. The invention features the full length nucleotide sequence of the novel gene, the cDNA sequence comprising the full length coding sequence of the novel phospholipase as well as the... Agent: Nixon & Vanderhye, PC

20100047878 - Method of producing l-amino acid: An L-amino acid is produced by culturing a microorganism belonging to the family Enterobacteriaceae having an L-amino acid-producing ability and modified so that glycerol dehydrogenase and dihydroxyacetone kinase activities are increased, in a medium containing glycerol as a carbon source to produce and accumulate an L-amino acid in the medium... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100047881 - Microorganisms with deregulated vitamin b12 system: The present invention relates to microorganisms with improved efficiency of vitamin B12 utilization.... Agent: Smith, Gambrell & Russell

20100047879 - Producing methionine without n-acyl-methionine: The present invention relates to a method for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulphur. The microorganism and/or the culture medium and/or the process parameters were modified in a way that... Agent: Bozicevic, Field & Francis LLP

20100047880 - Production of n-acylated sulphur-containing amino acids with microorganisms having enhanced n-acyltransferase enzymatic activity: The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferase enzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. Overexpression in sulphur-containing amino acid producing microorganisms permits the production of large amounts of N-acylated sulphur-containing... Agent: Bozicevic, Field & Francis LLP

20100047882 - Method of recovering l-threonine from l-threonine fermentation broth using nonsolvent: Provided are a method of recovering L-threonine from the fermentation broth of an L-threonine producing microorganism, comprising: separating microbial bodies from the L-threonine containing fermentation broth obtained by culturing an L-threonine producing microorganism and filtering the separated fermentation broth to obtain a filtrate; concentrating the filtrate; and reacting the concentrated... Agent: Cantor Colburn, LLP

20100047884 - Method for producing biodiesel: The invention relates to the utilisation of fatty materials with substantial free fatty acid content in the production of biodiesel by the use of microbial enzymes that are effective in a solvent-free process for the production of esters of fatty acids and C1-C3 alkyl alcohols.... Agent: Novozymes North America, Inc.

20100047883 - Process for producing useful substance using immobilized enzyme: In the process for producing a useful substance, which is performed by feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, the flow of the reaction liquid inside the column can be made uniform, and as a result, reactivity... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100047885 - Pantothenate kinase overexpression and pantothenic acid supplementation in actinomycetes: The invention relates to the synthesis of polyketides in Actinomycetes by overexpression of pantothenate kinase and supplementation with pantothenic acid. This results in increasing in vivo CoA production and thereby drives increased production of secondary metabolites, such as polyketides.... Agent: Baker & Mckenzie LLP

20100047886 - Method of conversion of syngas using microorganism on hydrophilic membrane: A stable system for producing liquid products such as ethanol, butanol and other chemicals from syngas components contacts CO or a mixture of CO2 and H2 with a hydrophilic membrane under anaerobic conditions and transfers these components into contact with microorganisms contained as a biofilm on the membrane. Maintaining the... Agent: Cardinal Law Group

20100047887 - Method for preparing hydroxytyrosol: The present invention relates to newly identified microorganisms capable of direct production of hydroxytyrosol (hereinafter also referred to as Hy-T) from tyrosol. The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Hy-T from tyrosol. Also included are methods/processes of using... Agent: Nixon & Vanderhye, PC

20100047888 - Method and apparatus for bio-fuel seeding: A method and apparatus is provided for microbial seeding and amendment of traditional alternative fuels production systems and processes using immobilized microbe bioreactors. The system addition utilizes attachment of yeast or other microbial consortia to a substrate to enhance alternative fuels production in fermentation processes. The system allows for the... Agent: Ted M. Anthony Babineaux, Poche, Anthony & Slavich, L.l.c

20100047889 - Method and apparatus for continuous flow bio-fuel production: A continuous flow system for production of bio-fuels using microbial cultures is provided. The present invention does not utilize batch type production, but follows a continuous flow protocol that eliminates much downtime inherent in conventional bio-fuel production systems while greatly reducing space and equipment requirements. Production is enhanced via controlled... Agent: Ted M. Anthony Babineaux, Poche, Anthony & Slavich, L.l.c

20100047890 - Methods and compositions for generating sporulation deficient bacteria: The present invention relates to methods and compositions for engineering sporulating bacterial cells, particularly a cell of the class Clostridia. In particular, the present invention relates to the generation of sporulation deficient bacteria for the generation of industrial superior phenotypes.... Agent: Casimir Jones, S.c.

20100047892 - Method for modifying cells: The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by changing sialylation and/or fucosylation levels of the cells. The invention is further directed to novel stem cells, the glycosylation... Agent: Birch Stewart Kolasch & Birch

20100047891 - Method of heat-stabilizing alpha-glucan phosphorylase (gp): An α-glucan phosphorylase having improved thermostability, which obtained by modifying natural α-glucan phosphorylase, and a method for producing this α-glucan phosphorylase having improved thermostability are provided. The natural α-glucan phosphorylase is derived from a plant, this α-glucan phosphorylase having improved thermostability has an amino acid residue which is different from... Agent: Mark D. Saralino (general) Renner, Otto, Boisselle & Sklar, LLP

20100047893 - Type iii t. brucei arginine methyltransferase: The invention relates to enzymes in Trypanosoma brucei, and in particular, protein arginine methyltransferases. A unique, highly active recombinant arginine methyltransferase capable of monomethylation of peptides and proteins is described.... Agent: Peter G. Carroll Medlen & Carroll, LLP

20100047894 - Use of matrix metalloproteinases, mutated and not mutated, for the preparation of pharmaceutical compositions, and mutated metalloproteinases with increased stability: The use of matrix metalloproteinases, mutated and not mutated, for the preparation of pharmaceutical compositions useful in the treatment of pathologies associated with an accumulation of matrix bio-polymers and/or an excess of TIMPs (Tissue Inhihitors MetalloProteinases) is described; mutated matrix metalloproteinases, in which at least an aminoacid residue in a... Agent: Clark & Elbing LLP

20100047895 - Methods for purification of bacterial cells and cell components: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.... Agent: Fulbright & Jaworski L.L.P.

20100047896 - Nucleic acid construct containing full length genome of human hepatitis c virus, recombinant full length virus genome-replicating cells having the nucleic acid construct transferred thereinto and method of producing hepatitis c virus particle: The present invention provides a method for replicating efficiently an RNA containing fulllength HCV genomic sequence and a method for producing HCV virus particles containing fulllength HCV replicon RNA or fulllength HCV genomic RNA by using a cell culture system. Further, the present invention relates to a method for producing... Agent: Birch Stewart Kolasch & Birch

20100047897 - Process for producing modified reconstituted sendai viral envelope specific for drug and/or gene delivery to liver cells: A process for producing a targeted gene and/or drug delivery system for liver cells comprising the steps of: i. chemical reduction of Sendai virus for reduction of HN protein; ii. subjecting the reduced virus to the step of dialysis for removal of the reducing agent; iii. solubilizing the reduced virus... Agent: The Webb Law Firm, P.C.

20100047898 - Mixing pipette: A pipette includes a tubular body having an internal passage, a first end and a second end. The tubular body is deformed inward to create a narrow constriction or slit within the internal passage of the pipette. When vacuum is applied to the pipette and a solution is drawn into... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100047899 - Process for cellular production of biologically active compounds: A process of increasing the cellular production of biologically active compounds is provided. The process is particularly useful for increasing antibiotic production by bacterial cells. The process includes the step of inhibiting the activity of methylmalonyl-CoA mutase.... Agent: Quarles & Brady LLP

20100047900 - Novel l-lysine-inducible promoter: Disclosed is a novel L-lysine-inducible promoter nucleic acid molecule. Also disclosed are a vector containing the nucleic acid molecule, a host cell transformed with the vector, and a method of inducing expression of a target gene using the L-lysine-inducible promoter nucleic acid molecule.... Agent: Casimir Jones, S.c.

20100047901 - System and method for electronic sensing of biomolecules: A nanoelectronic device is combined with a cellular membrane component to provide a sensor for biomolecules or to provide information about the structure of the membrane. The nanoelectronic device may comprise a network of randomly-oriented nanotubes, or other nanostructure, arranged on a substrate with adjacent electrodes so as to operate... Agent: Weaver Austin Villeneuve & Sampson LLP

20100047902 - Transfer device for culture vessel, culture device and holder for culture vessel: A transfer device for a culture vessel for transferring a culture vessel for culturing a cell, a culture device including the transfer device for a culture vessel, and a holder for a culture vessel for holding a culture vessel, in which the transfer device for a culture vessel includes a... Agent: Oliff & Berridge, PLC

20100047904 - Materials, methods and systems for purification and/or separation: Materials, methods and systems are provided for the purification, filtration and/or separation of certain molecules such as certain size biomolecules. Certain embodiments relate to supports containing at least one polymethacrylate polymer engineered to have certain pore diameters and other properties, and which can be functionally adapted to for certain purifications,... Agent: Jones Day

20100047903 - Methods of processing compositions containing microparticles: Methods for processing microparticles involve providing a composition comprising a plurality of solid microparticles and at least one non-volatile material, providing a non-solvent, and exposing the composition to the non-solvent to remove at least a portion of the non-volatile material from the composition while retaining at least the microparticles.... Agent: Marshall, Gerstein & Borun (baxter)

20100047905 - Simulated blood components and methods: A control and a cellular fraction for use therein and methods for making the same, including a first cellular component including a plurality of a first group of processed animal red blood cells other than human blood cells; a second cellular component including a plurality of a second group of... Agent: Dobrusin & Thennisch PC

20100047906 - Germ lineage derived feeder cells and methods thereof: The present disclosure relates to human germ layer derived feeder cells (GLDF cells) and method of generation thereof. Further, it relates to a method for culturing and propagating human embryonic stem cells (hESCs) in a substantially undifferentiated state for several passages on the human GLDF cells. In particular, the present... Agent: Schwegman, Lundberg & Woessner, P.A.

20100047907 - Methods of transporting epithelial cell monolayers: Described herein are tissue culture plates with permeable tissue culture plate inserts therein, which provides the tissue culture plates with apical chamber and a basolateral chambers, wherein cells are deposited on the permeable tissue culture inserts and essentially all of tissue culture medium has been removed from the apical chambers... Agent: Woodcock Washburn LLP

20100047908 - Monocyte-derived stem cells: Methods for generating multipotent stem cells from adult peripheral blood monocytes are provided. Monocytes may be de-differentiated into monocyte-derived stem cells (MDSCs) by contacting the monocyte with the de-differentation factors, leukocyte inhibitory factor, macrophage colony-stimulating factor, or a combination thereof. The MDSCs may be differentiated into many different types of... Agent: Polsinelli Shughart PC

20100047909 - Nucleic acid compounds for inhibiting vegf family gene expression and uses thereof: The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing one or more VEGF family gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.

20100047910 - Supramolecular complexes as photoactivated dna cleavage agents: The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated.... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20100047911 - Compositions and methods for isolation, propagation, and differentiation of human stem cells and uses thereof: The invention is directed to the field of human stem cells and includes methods and compositions for isolating, propagating, and differentiating human stem cells. The invention provides therapeutic uses of the methods and compositions, including autologous transplantation of treated cells into humans for treatment of Parkinson's and other neuronal disorders.... Agent: Knobbe Martens Olson & Bear LLP

20100047912 - Apparatus, method and system for creating, collecting and indexing seed portions from individual seed: A method, apparatus, and system for coating, singulating, aligning, ablating, and indexing a number of seeds for testing is described. The apparatus has a carrier designed to hold seeds in a predetermined alignment for ablating a seed sample from a seed portion, the seed portions are indexed to the seed... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pioneer Hi-bred

  
02/18/2010 > patent applications in patent subcategories. patent applications/inventions, industry category

20100041009 - Method for isolation of afterbirth derived cells: A method for extracting cells from afterbirth tissue, including placing the afterbirth into a perfusion circuit prior to exsanguination, extracting the cells from the afterbirth with digestive enzymes and mechanically recovering cells from the digested afterbirth tissue, and isolating the cells from the perfusate and digestion mix. Also disclosed is... Agent: Knoble, Yoshida & Dunleavy

20100041012 - Rationally designed antibodies: Antibodies or fragments thereof having CDR regions replaced or fused with biologically active peptides are described. Flanking sequences may optionally be attached at one or both the carboxy-terminal and amino-terminal ends of the peptide in covalent association with adjacent framework regions. Compositions containing such antibodies or fragments thereof are useful... Agent: Ropes & Gray LLP

20100041011 - Reference control for cell by cell analysis: A reference control for cell by cell analysis on flow cytometric analyzers contains cellular analogs made of permeated blood cells containing therein aggregated intracellular proteins and preserved antigenic sites thereof, having cellular membrane permeable to antibodies and a suspension medium. The reference control is frozen after being prepared and thawed... Agent: Beckman Coulter, Inc. Mitchell E. Alter

20100041010 - Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue: The invention relates to a method of treatment of collagenous connective tissue removed from a donor for implant into a recipient which is re-habited or re-colonized by host cells without an immune rejection and inflammatory reaction. After removal from the donor the tissue is trimmed and thereafter soaked in a... Agent: Frederick Gotha

20100041021 - Apparatus and method for measuring concentration of molecules through a barrier: An apparatus and method for detecting the presence and measuring the concentrations of molecules through a barrier and/or at a distance utilizes the principle of chemical/electrostatic attraction (hereinafter “affinity”), i.e., the affinity between charged atoms and molecules that cause their chemical interactions and reactions, to infer, based on the behavior... Agent: Bacon & Thomas, PLLC

20100041013 - Assay for a health state: The invention relates to an assay for determining a health state of a subject using a combination of detecting the presence of a virus and detecting the presence of a genomic target or marker indicative of a health state.... Agent: Knobbe Martens Olson & Bear LLP

20100041014 - Biological targeting compositions and methods of using the same: Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the... Agent: Searete LLC Clarence T. Tegreene

20100041015 - Competitive enzyme linked immunosorbent assay (c-elisa) for the detection of a flavivirus specific antibody: A competitive enzyme-linked immunosorbent assay (C-ELISA), using flavivirus member specific immunological agents was developed to detect antibody specific to members of the flaviviruses indicative of exposure to flavivirus. The test is based on a competition for epitope binding on the envelope protein of the flavivirus antigen captured using anti-flavivirus IgA... Agent: Knobbe Martens Olson & Bear LLP

20100041017 - Fluorescent semiconductor microparticle assembly, fluorescent labeling agent assembly for biological substance, and bioimaging method and biological substance analysis method using the assemblies: Disclosed is a fluorescent semiconductor microparticle assembly comprising at least three kinds of fluorescent semiconductor microparticles with an average particle size of from 1 to 10 nm, having the same chemical composition, a different average particle size and a different emission maximum wavelength in the emission spectra, wherein a standard... Agent: Lucas & Mercanti, LLP

20100041018 - Method to detect virus related immunological markers for the diagnosis of hepatitis c virus infection: This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HCV-associated immunological markers in a serum sample for the diagnosis of HCV infection. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in... Agent: Weili Cheng

20100041016 - Methods for detecting organisms and enzymatic reactions using raman spectroscopy and aromatic compounds comprising phosphate: The present disclosure provides systems for the rapid and sensitive detection of organisms and molecules in samples. Reactants that produce Raman-active products are used in combination with Raman light scattering. Such compounds may comprise phosphates permitting the detection of phosphatases. The present disclosure can also be used to measure enzyme-kinetics.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100041020 - Methods for detecting the presence, location or quantity of targets using novel dyes: The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides... Agent: Enzo Biochem, Inc.

20100041019 - Methods of screening for respiratory synctial virus and human metapneumovirus: Provided are nucleic acid primers and probes for use in diagnostic assays to screen for respiratory infections, such as respiratory syncytial virus (“RSV”) and human metapneumovirus (hMPV). The primers and probes may be used to screen for RSV or hMPV in a singleplex assay or they may be used in... Agent: Siemens Corporation Intellectual Property Department

20100041022 - Novel assay for the separation and quantification of hemagglutinin antigens: Described are methods for separating hemagglutinin (HA) antigens, comprising the steps of applying a reduced and derivatized antigen preparation comprising solubilized HA antigens and a detergent in a pH controlled solution, on a Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) column; and eluting the HA antigens from the column with an ion... Agent: Traskbritt, P.C.

20100041044 - Amplicon melting analysis with saturation dyes: Methods are provided for nucleic acid analysis wherein a target nucleic acid that is at least partially double stranded is mixed with a dsDNA binding dye having a percent saturation of at least 50% to form a mixture. In one embodiment, the nucleic acid is amplified in the presence of... Agent: Ice Miller LLP

20100041039 - Analysis of nucleic acid obtained from nucleated red blood cells: The present invention is particularly useful for extracting DNA from nucleated RBCs. Therefore, the methods of the invention can be applied towards the genetic analysis of avians, fish, reptiles and amphibians.... Agent: Synageva Biopharma Corp.

20100041024 - Bisulfite conversion of dna: The present invention relates to an improved method for the bisulfite conversion of DNA. In certain time-temperature ranges the efficacy of the bisulfite conversion is clearly improved. By combination with denaturating solvents, new reaction conditions and new purification methods the efficacy can be further increased The converted DNA can subsequently... Agent: Kriegsman & Kriegsman

20100041042 - Breeding and milking cows for milk free of beta-casein a1: A milk or other dairy product, capable of minimising the onset of disease such as coronary heart disease or enhancing the immune response is derived from animals which are substantially free of the β-casein A allele. Bulk milk can be produced by testing for and culling cows who test positive... Agent: Young & Thompson

20100041048 - Circulating mutant dna to assess tumor dynamics: DNA containing somatic mutations is highly tumor specific and thus, in theory, can provide optimum markers. However, the number of circulating mutant gene fragments is small compared to the number of normal circulating DNA fragments, making it difficult to detect and quantify them with the sensitivity required for meaningful clinical... Agent: Banner & Witcoff, Ltd.

20100041032 - Composition and methods for the detection of cripto-3: The present invention is based, at least in part, on the discovery that the pseudogene TDGF3 (Cripto-3) is expressed in cells and, in particular, that TDGF3 overexpression is associated with transformation of a cell, e.g., TDGF3 is overexpressed in cancer cell lines and cells from tumor tissue. Accordingly, the invention... Agent: Lahive & Cockfield, LLP / Biogen Idec Floor 30, Suite 3000

20100041025 - Compositons, methods and kits for real-time nucleic acid analysis in live cells: The present invention includes compositions, methods and kits for the real-time detection of transcription and translation in live cells, tissues and organisms. The present invention further provides method for the rapid sequencing of nucleic acids without using conventional sequencing techniques or reactions.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20100041049 - Detecting nucleic acid: This document provides methods and materials for detecting target nucleic acid. For example, methods and materials for detecting the presence or absence of target nucleic acid, methods and materials for detecting the amount of target nucleic acid present within a sample, kits for detecting the presence or absence of target... Agent: Fish & Richardson P.C.

20100041030 - Displacement assay for detecting nucleic acid oligomer hybridization events: Described is a method for detecting nucleic acid oligomer hybridization events that comprises the steps providing a modified surface, the modification consisting in attaching at least one type of probe nucleic acid oligomer, providing at least one type of signal nucleic acid oligomer, the signal nucleic acid oligomers being modified... Agent: Pearl Cohen Zedek Latzer, LLP

20100041050 - Disposable reactor module and detection system: A disposable reactor module, monitoring/optical detection system and related hardware for, inter alia, chemical reactions including Polymerase Chain Reactions.... Agent: Fish & Richardson PC

20100041057 - Dna methylation detection methods: The present teachings provide DNA methylation quantification methods that avoid bisulfite treatment of DNA. Methylation-specific binding proteins (MeDNA binding proteins) and non-methylation specific binding proteins (non-MeDNA binding proteins) are employed in various embodiments to modulate the accessibility of nucleic acids to primer extension reactions. After selectively removing the target nucleic... Agent: Life Technologies Corporation C/o Intellevate

20100041047 - Efficient reduction of target rna's by single- and double-stranded oligomeric compounds: The present invention provides, inter alia, methods of selecting a single-stranded oligomeric compounds for inhibiting RNA expression, methods of generating double-stranded oligomeric compounds, methods of identifying optimized double-stranded oligomeric compounds, methods of selecting optimized single-stranded oligomeric compounds, methods of selecting optimized double-stranded oligomeric compounds, methods of identifying multifunctional oligomeric compounds,... Agent: Woodcock Washburn LLP

20100041037 - Genetic variants contributing to risk of prostate cancer: The present invention is characterised by certain genetic variants being susceptibility variants for prostate cancer. The invention relates to methods of determining increased susceptibility to prostate cancer, as well as methods of determining decreased susceptibility to prostate cancer, using such variants. The invention further relates to kits for determining a... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100041036 - Genomic morse code: The present invention relates to a method of detection of the presence of at least one domain of interest on a macromolecule to test, wherein said method comprises the following steps: a) determining beforehand at least two target regions on the domain of interest, designing and obtaining corresponding labeled probes... Agent: Foley And Lardner LLP Suite 500

20100041035 - Identification of centromere sequences and uses therefor: Provided herein are methods for identifying centromeres and centromeres identified by such methods. Centromeres of organisms such as algae, fungi, and protists can be used, for example, for constructing artificial chromosomes and cells containing such artificial chromosomes.... Agent: Synthetic Genomics C/o Mofo

20100041040 - Internally controlled multiplex detection and quantification of microbial nucleic acids: The present invention relates to new methods and uses for the detection and quantification of microbial nucleic acids employing an internal quantitative reference. Preferred methods are based on the amplification of nucleic acids, preferably the polymerase chain reaction. Further provided are kits comprising components for performing said methods and uses.... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100041060 - Iron-regulating protein-2(irp-2) as a diagnostic for neurodegenerative disease: The present invention relates to the discovery of markers for neurodegenerative disease. More particularly, it was discovered that forms of IRP-2 protein that are unable to undergo oxidation at critical cysteine residues are diagnostic for neurodegenerative disease including, but not limited to Alzheimer's disease. Embodiments include nucleic acids that encode... Agent: Knobbe Martens Olson & Bear LLP

20100041046 - Method and apparatus for the discretization and manipulation of sample volumes: Embodiments of the present invention relate to methods and apparatuses for the discretization and manipulation of sample volumes that is simple, robust, and versatile. It is a fluidic device that partitions a sample by exploiting the interplay between fluidic forces, interfacial tension, channel geometry, and the final stability of the... Agent: Townsend And Townsend And Crew, LLP

20100041038 - Method for discriminating single nucleotide polymorphisms: A method for discriminating single nucleotide polymorphisms (SNPs) offers improved sensitivity and specificity. A test kit is also provided. The method may be for genotyping in typing assays applied to a biological sample. The method may include steps of performing a real-time amplification of the target, generating multiple copies of... Agent: Oliff & Berridge, PLC

20100041026 - Method for identiflying modulators of rufy2 useful for treating alzheimer's disease: Compositions and methods for identifying modulators of RUFY2 are described. The methods are particularly useful for identifying analytes that antagonize RUFY2's effect on processing of amyloid precursor protein to Aβ peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease.... Agent: Merck And Co., Inc

20100041034 - Method for manipulating samples with magnetic nucleation nanoparticles: A method for manipulating a sample by utilizing a nucleic acid binding substance which has affinity for nucleic acid polymers. The nucleic acid binding substance is comprised of a nucleic acid binding element capable of specific binding to nucleic acid molecules and connected to a nucleation nanoparticle having paramagnetic properties.... Agent: Hiscock & Barclay, LLP

20100041043 - Method for the diagnosis and follow-up of schizophrenia and other mental and neurological disorders: A method for the diagnosis and follow up of a mental disorder or of a neurodegenerative disorder in an individual, comprises: (i) measuring mRNA of D3 dopamine receptor and/or of α7 nicotinic acetylcholine receptor (α7 AChR) and of a control gene in peripheral blood lymphocytes (PBLs) of said individual and... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100041059 - Method of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients: A method of determining a potential of a diabetic patient to benefit from anti oxidant therapy for treatment of a vascular complication, the method comprising determining a haptoglobin phenotype of the diabetic patient and thereby determining the potential of the diabetic patient to benefit from said anti oxidant therapy, whereby... Agent: Pearl Cohen Zedek Latzer, LLP

20100041054 - Methods for the production of ips cells: Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating induced pluripotent stem cells using reporter genes are described. Furthermore, the invention provides novel reprogramming vectors employing reporter genes.... Agent: Fulbright & Jaworski L.L.P.

20100041027 - Methods of assessing coronary artery disease: An association between the Ala allele of the P12A variant of the human PPARγ gene and development of CAD, particularly premature CAD, in individuals, and specifically in women, particularly Caucasian women, is described, as are methods of assessing or predicting the likelihood or risk that an individual, such as a... Agent: Wolf Greenfield & Sacks, P.C.

20100041055 - Novel gene normalization methods: Measurement of gene expression relative to an endogenous control gene is prone to excessive variability between samples and even replicates. The disclosure provides methods for normalizing expression levels of a gene by scaling gene expression levels to that of the most highly expressed gene in the set of genes whose... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100041045 - Nucleic acid fluorescent stains: The present invention provides fluorescent dye compounds and methods of using the compounds for the staining of nucleic acids including qPCR applications. In particular, the dye compounds comprise heterocyclic molecules with hydroxy alkyl and aromatic substituents, and the dye compounds form highly fluorescent complexes upon nucleic acid binding.... Agent: Polsinelli Shughart PC

20100041041 - Nucleotides and nucleosides and methods for their use in dna sequencing: The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA... Agent: Fulbright & Jaworski L.L.P.

20100041031 - Optoelectronic detection system: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100041058 - Pim-3 kinase as a target for type 2 diabetes mellitus: The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100041053 - Proofreading primer extension: The present invention provides for primer extension reactions, including polymerase chain reactions, in which a polymerase having 3′-5′ exonuclease activity edits a primer that is not fully complementary thereby allowing for amplification and detection of target nucleic acids that may have variability in their sequences.... Agent: Townsend And Townsend And Crew, LLP

20100041051 - Prostate cancer methylation assay: An assay for diagnosing or prognosticating prostate cancer incorporates the detection of hypermethylation of SEQ ID NO 1, SEQ ID NO 3, and SEQ ID NO 2 genes and may be incorporated into a nomogram.... Agent: Philip S. Johnson Johnson & Johnson

20100041052 - Receptor tyrosine kinase assays: Methods for detecting phosphorylation of receptor tyrosine kinases (“RTKs”) upon activation are provided. The method employs cells comprising two fusion products: (1) an RTK fused to a small fragment of β-galactosidase and (2) a phosphotyrosine binding peptide fused to the large fragment of β-galactosidase, where the 2 fragments weakly complex... Agent: Peters Verny , L.L.P.

20100041033 - Site specific system for generating diversity protein sequences: This invention relates to the diversification of nucleic acid sequences by use of a nucleic acid molecule containing a region of sequence that acts as a template for diversification. The invention thus provides nucleic acid molecules to be diversified, as well as those which act as the template region (TR)... Agent: Dla Piper LLP (us)

20100041029 - Synthesis of four color 3'o-allyl, modified photocleavable fluorescent nucleotides and related methods: This invention provides a process for making 3′-O-allyl-dGTP-PC-Biodopy-FL-510, 3′-O-allyl-dATP-PC-ROX, 3′-O-allyl-dCTP-PC- and 3′-O-allyl-dUTP-PC-R6G, and related methods.... Agent: Cooper & Dunham, LLP

20100041056 - Temperature controlled nucleic-acid detection method suitable for practice in a closed-system: The invention relates to a method that utilizes thermophilic proteases for the treatment of nucleic acids in a closed-system to be used in tandem with methods for the rapid detection of target nucleic acids present in a sample. These combined methods enable simplified, temperature-controlled devices to be used for accurate,... Agent: Morrison & Foerster LLP

20100041028 - Zinc finger binding domains for gnn: Zinc finger-nucleotide binding polypeptides having binding specificity for target nucleotides containing one or GNN triplets are provided. Compositions containing such polypeptides and the use of such polypeptides and compositions for regulating gene expression are also provided.... Agent: Schwegman, Lundberg & Woessner, P.A.

20100041023 - Inactivated fcv vaccines: The present invention relates to improved inactivated feline calicivirus (FCV) vaccines. The invention also provides a process for producing stabilized inactivated FCV, and the use of such stabilized inactivated FCV, in the production of FCV immunogenic compositions. The invention further provides methods of inducing an immune response in an animal... Agent: Judy Jarecki-black, Esq. Merial Limited

20100041063 - Anti-drug antibody assay: The invention provides an antibody binding specifically to Cynomolgus IgG characterized by not binding to Human IgG, and a method for the immunological determination of an immune complex (DA/ADA complex) of a drug antibody (DA) and an antibody against said drug antibody (anti-drug antibody, ADA) in a sample of a... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100041065 - Detection method, sample cell and kit for detection and detection apparatus: A labeling binding substance in an amount corresponding to the amount of a detection target substance contained in a liquid sample binds to a sensor portion, and the amount of the detection target substance is detected based on the amount of signal light output by excitation of a label of... Agent: Sughrue Mion, PLLC

20100041062 - Devices, systems, and methods for aiding in the detection of a physiological abnormality: The present invention comprises a method for identifying the presence or absence of a pulmonary embolism using a combination of tests and brightline thresholds. The first test is a blood based test measuring D-Dimer concentration and the second test is a respiratory analysis that determines a carboximetry ratio. If the... Agent: Kevin M. Farrell Pierce Atwood LLP

20100041064 - Diagnosis and risk stratification of infections and chronic diseases of the respiratory tract and lungs by means of provasopressin, particularly copeptin or neurophysin ii: The invention relates to a method for diagnosing and/or stratifying the risk of infections or chronic diseases of the respiratory tract and lungs, particularly lower respiratory tract infections and chronic obstructive pulmonary disease. In said method, provasopressin (proAVP) or fragments or partial peptides thereof, especially copeptin or neurophysin II, is/are... Agent: Connolly Bove Lodge & Hutz, LLP

20100041061 - Enhancing endotoxin detection: Provided herein are methods for detecting gram negative bacteria or lipopolysaccharide in a sample. Kits for detecting gram negative bacteria or lipopolysaccharide in a sample are provided.... Agent: Fish & Richardson P.C.

20100041066 - Non-precipitating bodily fluid analysis system: A bodily fluid analyzer including a dry test strip impregnated with a reagent providing a non-precipitating reaction to exclude non-desired analytes. The reagent complexes the non-desired analytes so they remain in solution but cannot participate in the test reaction. Red blood cells are removed from the detection area by slowing... Agent: Patton Boggs LLP

20100041067 - Reaction sensing in living cells: Chemical reactions occurring within a living cell are measured in a manner that does not affect the viability of the cell or the reaction under study. In one embodiment, one or more sensors are introduced into the cell and/or covalently associated with the exterior cell membrane. The sensor(s) emit an... Agent: Goodwin Procter LLP Patent Administrator

20100041072 - Process for identifying a ligand that binds to the nep binding site for the smr1 pentapeptide: The invention relates to the therapeutic use of a SMR1-peptide or a pharmaceutically active amount of said SMR1-peptide, for the preparation of a therapeutic composition for preventing or treating diseases wherein a modulation of the activity of a membrane metallopeptidase, notably a membrane-zinc metallopeptidase, is sought, in a mammal, specifically... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100041074 - Pharmaceutical composition comprising anti-grp78 antibody as active ingredient: The present inventor attempted to prepare antitumor antibodies that would target GRP78 the localization of which in cancer cells changed to the cell membrane and the inventor successfully obtained an anti-GRP78 antibody that would bind specifically to the cell surface of cancer cells; this eventually led to the accomplishment of... Agent: Foley And Lardner LLP Suite 500

20100041073 - Two helix binders: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of a covalent bridge between two modified amino acids in the polypeptide is provided here. Also provided are methods... Agent: General Electric Company Global Research

20100041075 - Tuberculosis diagnostic test: A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which... Agent: Baker Botts L.L.P.

20100041068 - Deeply quenched enzyme sensors and binding sensors: Sensors for detecting enzyme activity are provided that include a substrate module comprising a substrate for the enzyme of interest and a fluorescent label, a quencher, and a detection module. The detection module binds to the substrate module either before or after the enzyme acts on the substrate and sequesters... Agent: Amster, Rothstein & Ebenstein LLP

20100041069 - Methods for diagnosing and monitoring liver diseases: A method of diagnosing a liver disorder in a subject is disclosed. The method comprises determining a level of sH2A and at least one additional liver marker in a sample of the subject wherein a change beyond a predetermined threshold in both the sH2A and the at least one additional... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100041070 - Immunoassay and method of use: A method for performing an immunoassay is described. The method is particularly useful for detecting extracellular polysaccharide (EPS) and/or lipopolysaccharide (LPS) producing microorganisms. The method is particularly useful for detecting microorganisms which produce extracellular polysaccharides (EPS) also known as exocellular polysaccharides, capsule, and/or lipopolysaccharides (LPS). In a preferred method for... Agent: Ian C. Mcleod, P.C.

20100041071 - Method for determination of molecular weight of hyaluronic acid: A method of measuring a molecular weight of hyaluronic acid, comprising at least reacting hyaluronic acid in a sample containing the hyaluronic acid with a hyaluronic acid-binding protein to measure an amount of the hyaluronic acid-binding protein that is bound to the hyaluronic acid in the sample or a value... Agent: Knobbe Martens Olson & Bear LLP

20100041078 - Antibody-based gamma-hydroxybutyrate (ghb) detection method and device: Gamma-hydroxybutyrate (GHB) can be used as a recreational party drug, aphrodisiac, and attenuator of other drugs and make a person a vulnerable target of robbery or rape. The present invention provides methods and kits for detection of GHB in a sample using an antibody-based assay. Antibodies that specifically bind to... Agent: Scully Scott Murphy & Presser, PC

20100041079 - Method for predicting cardiovascular events: A novel method for assessing the risk of a cardiovascular event is provided. The concentration of 11-dehydro thromboxane in a urine sample is measured and compared to a set of standardized quartile concentrations. A concentration of urinary 11-dehydro thromboxane that falls within the fourth quartile is indicative of a greatly... Agent: Occhiuti Rohlicek & Tsao, LLP

20100041077 - Pesticide biomarker: Provided are methods, compositions and articles of manufacture for detecting biomarkers indicative of exposure of a mammal to organophosphate compounds. The interaction of such a biomarker with a receptor bound to a biopolymer results in an optical readout that reports the presence of the biomarker.... Agent: Angelo Castellino

20100041076 - Reagents, methods and kits for the universal rapid immuno-detection: This invention relates to a novel immuno-detection methods, kits and reagents. The Combination of this invention, combining at least two of the following reagents of a Non-specific Competitor, a Specific Indicator, a primary antibody and an antigen, provides a faster and easier method for an immuno-detection, combining at least two... Agent: Graham Curtin, P.A.

20100041080 - Method for quantification of cholesterol in small dense low-density lipoprotein: A method for determination of sdLDL-C, which comprises the steps of: (i) in a reaction solution containing a surfactant which preferentially inhibits the reaction of sdLDL-C with enzymes for cholesterol measurement such as cholesterol ester hydrolase, allowing the enzymes for cholesterol measurement to act on a sample to eliminate HDL-C,... Agent: Fitzpatrick Cella Harper & Scinto

20100041081 - Protocol for risk stratification of ischemic events and optimized individualized treatment: A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit preparation of an individualized assessment of ischemic event... Agent: Anthony G Sitko PLC

20100041084 - Analyte testing method and system: Described and illustrated herein is an exemplary method of operating an analyte measurement device having a display, user interface, processor, memory, and user interface buttons. Such method can be achieved by measuring an analyte with the analyte measurement device, displaying a value representative of the analyte, querying a user to... Agent: Philip S. Johnson Johnson & Johnson

20100041083 - Meter adapted to simultaneously display the number of high, low and total test results: A meter adapted for evaluating, saving and simultaneously displaying the number of analyte concentration readings that are greater than a first predetermined analyte concentration level, the number of analyte concentration readings that are less than a second predetermined analyte concentration level and the total number of analyte concentration readings over... Agent: Nixon Peabody LLP

20100041082 - Methods for determining the metabolism of sugars and fats in an individual: Provided herein are methods for determining the metabolism of one or more sugars and/or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis and glycolysis, which are believed to be early markers for predicting elevated risk of diabetes and cardiovascular disease. Other applications include methods... Agent: Morrison & Foerster LLP

20100041085 - Methods and kits for assaying acetyl transferase or deacetylase activity: The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular... Agent: Hugh Mctavish Mctavish Patent Firm

20100041086 - Enzyme assays for a droplet actuator: The invention relates to a microfluidic platform and methods of using the platform for conducting enzyme assays using a droplet actuator. The enzyme assays of the invention are useful for, among other things, identifying and/or characterizing disorders resulting from conditions in which enzymes are defective or are produced in inappropriate... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20100041087 - Detection of specific binding reactions using magnetic labels: The present invention is a novel biosensor composed of mOrange2 and mCherry fluorescent proteins operably linked via a linker, which provides a distinct color change upon separation of the fluorescent proteins.... Agent: Licata & Tyrrell P.C.

20100041088 - Mutant protein having diaphorase activity: Mutant diaphorase is capable of having, when forming a complex with a coenzyme, flavin mononucleotide, a conformation in which the distance between tryptophan at the 60th position from an N terminus and imino nitrogen at the 1-position of the coenzyme, flavin mononucleotide, is larger than that in a conformation of... Agent: K&l Gates LLP

20100041093 - Devices and method for electrophysical cell analyses: Disclosed is a liquid holder mechanism (10) which is designed to form a liquid environment at a capillary tip (22) of a patch clamp pipette (20) and includes a holding element (11.2) for retaining a liquid drop (1) and at least one rod (12.2, 12.3) for positioning the holding element... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20100041092 - Drug controlled molecular tags: The disclosure provides method and compositions for visualizing protein turnover. In particular, the disclosure provides methods and compositions useful for measuring the age of particular proteins or the dynamics of localized protein translation.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100041090 - Embryo quality assessment based on blastomere division and movement: The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20100041089 - Improved method for detecting chemical substances: The present invention provides an assay method for conveniently and easily detecting existence or a quantity of a chemical substance in the environment without relying on expensive measurement devices used in fluorometry. More specifically, the present invention is characterized in that a transformed cell which is transformed by operably linking... Agent: Birch Stewart Kolasch & Birch

20100041091 - Microfluidic embedded polymer nems force sensors: A method of screening one or more cells is described; the method includes: (i) providing one or more cells to a nanoelectromechanical system (NEMS) force sensor; (ii) applying at least one reagent to the one or more cells; and (iii) observing a response of the one or more cells to... Agent: Foley And Lardner LLP Suite 500

20100041094 - Mobile intra-operative microscopic diagnosis laboratory: A mobile intra-operative microscopic diagnosis laboratory capable of analyzing fresh tissue specimens and providing intra-operative consultation within 20 minutes is described. The mobile laboratory is preferably a van and contains a cryostat for freezing the fresh tissue specimens and a means for cutting the specimens. In addition, it also contains... Agent: John C. Andrade, Esquire Parkowski, Guerke & Swayze, P.A.

20100041095 - Pneumatic bioreactor: A pneumatic bioreactor includes a vessel containing a fluid to be mixed and at least one mixing device driven by gas pressure. A first embodiment includes a floating impeller that rises and falls in the fluid as gas bubbles carry it upward to the surface where the gas is then... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100041096 - Carcinostatic method using brca1-bard1 pathway: The present invention provides a method of polyubiquitinating a nucleophosmin comprised of reacting the nucleophosmin in vitro or in vivo with BRCA1-BARD1. The present invention also provides a method of inhibiting polyubiquitination of nucleophosmin comprised of phosphorylating BARD1 using CDK2-cyclin E and/or CDK2-cyclin A.... Agent: Dickstein Shapiro LLP

20100041099 - Cells expressing pichia cytochrome c: Described herein are recombinant yeast cells that express a cytochrome C gene the expression of which causes the recombinant yeast cells to (i) grow faster than wild type yeast cells of the same species when cultured on glucose medium, and (ii) accumulate high levels of polyunsaturated fatty acid precursor molecules... Agent: Foley & Lardner LLP

20100041101 - Expression system for recombinant human arginase i: A novel recombinant protein expression system is provided for improving expression of recombinant human arginase I. The system contains an isolated and purified nucleic acid molecule for constructing plasmid and E. coli strain in order to improve the expression of recombinant human arginase I. In another aspect of the present... Agent: EagleIPLimited

20100041100 - Family 6 cellulase with decreased inactivation by lignin: A modified Trichoderma reesei Family 6 (TrCel6A) cellulase enzyme comprising amino acid substitutions at one or more positions selected from the group consisting of 129, 322, 363 and 410 of SEQ ID NO: 1 is provided. Genetic constructs and genetically modified microbes comprising nucleic sequences encoding the modified TrCel6a cellulase... Agent: Fitzpatrick Cella Harper & Scinto

20100041098 - Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells: The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.... Agent: Dean G. Stathakis Allergan, Inc. -t2-7h

20100041097 - Synthetic gene control region: The present invention provides a synthetic gene control region which comprises a gene regulatory sequence comprising a binding site for a gene regulatory protein of a yeast strain, and a promoter from filamentous fungal strain located downstream of the gene regulatory sequence; wherein the promoter can be recognized by the... Agent: Merck And Co., Inc

20100041102 - Antagonists of pcsk9: Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors,... Agent: Merck And Co., Inc

20100041103 - Composition and method for enhancing cell growth and cell fusion: A method of cell-fusion is provided, the method comprising fusing cells in a medium comprising a liquid composition having a liquid and nanostructures, each of the nanostructures comprising a core material of a nanometric size surrounded by an envelope of ordered fluid molecules, the core material and the envelope of... Agent: Foley And Lardner LLP Suite 500

20100041104 - Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.... Agent: Danisco US Inc. Attention: Legal Department

20100041105 - Dna in the presence of gellan: A method is provided for nucleic acid amplification with enhanced sensitivity. The method for enhanced sensitivity involves carrying out the amplification reaction in the presence of gellan. For instance, the method allows for the production of detectable amounts of PCR amplified DNA from at least 10 fold fewer target molecules... Agent: Seed Intellectual Property Law Group PLLC

20100041106 - Recombinant gras strains expressing thermophilic arabinose isomerase as an active form and method of preparing food grade tagatose by using the same: The present invention relates to a recombinant GRAS (Generally Recognized As Safe) strains expressing thermophilic arabinose isomerase as an active form and method of food grade tagatose by using the same, and more precisely, a gene encoding arabinose isomerase originating from the thermophilic Geobacillus stearothermophilus DSM22 and Geobacillus thermodenitrificans, a... Agent: Occhiuti Rohlicek & Tsao, LLP

20100041108 - Method for producing l-methionine by fermentation: The present invention provides a method for producing L-methionine by culturing a microorganism in a medium to produce and accumulate L-methionine in the medium, and collecting the L-methionine from the medium, where the microorganism is deficient in a repressor of L-methionine biosynthesis system and has L-methionine productivity.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100041107 - Method of reducing gene expression using modified codon usage: The present invention is directed to a method of reducing the amount of at least one polypeptide in a host cell by expressing a nucleotide sequence encoding for the polypeptide in the host cell wherein the nucleotide sequence uses codons that are rarely used according to the codon usage of... Agent: Connolly Bove Lodge & Hutz, LLP

20100041109 - Corynebacterium glutamicum variety producing l-arginine and method for fabricating the same: The present invention relates to an L-arginine producing mutant strain, and a method for fabricating the same. In particular, the present invention relates to a polynucleotide comprising an argD2 gene (Ncgl2355) that is a putative gene of acetylornithine aminotransferase involved in arginine biosynthesis of Corynebacterium glutamicum, a polypeptide encoded by... Agent: Brinks Hofer Gilson & Lione

20100041110 - R-hydroxynitrile lyases having improved substrate acceptance and the use thereof: R-hydroxynitrile lyases having an improved substrate acceptance, increased activity and increased selectivity, in which there is replacement in the amino acid sequence of R-hydroxynitrile lyases from the Rosaceae family either a) of the amino acid residue which corresponds to position 360 of the mature PaHNL5 protein by another apolar amino... Agent: Nixon & Vanderhye, PC

20100041113 - Delta 6 desaturases and their use in making polyunsaturated fatty acids: The present invention relates to Δ6 desaturases, which have the ability to convert linoleic acid [“LA”; 18:2 ω-6] to γ-linolenic acid [“GLA”; 18:3 ω-6] and/or α-linolenic acid [“ALA”; 18:3 ω-3] to stearidonic acid [“STA”; 18:4 ω-3]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ6 desaturases, along... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100041111 - Immobilized enzymes and methods of using thereof: The disclosed matter relates to immobilized enzymes and methods of use thereof.... Agent: Ballard Spahr LLP

20100041114 - Process for producing useful substance with immobilized enzyme: Even when a reaction column having a large column diameter is used in the reaction performed by feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, the flow of the whole reaction liquid inside the column can be made... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100041112 - Production of biodiesel: The invention relates to the production of biodiesel feedstock and biodiesel. A process for producing a biodiesel utilising a thraustochytrid is provided.... Agent: Bozicevic, Field & Francis LLP

20100041115 - Production of dicarboxylic acids by improved mutant strains of yarrowia lipolytica: The invention concerns a method for producing dicarboxylic acids (DCA) with long hydrocarbon chains, also called diacids, which consists in culturing a mutant strain of Yarrowia lipolytica obtained by mutagenesis directed and more particularly disrupted at least for the POX2, POX3, POX4 and POX5 genes encoding acyl-CoA oxydase, in a... Agent: Millen, White, Zelano & Branigan, P.C.

20100041116 - Method for producing ethanol using raw starch: The present invention relates to methods for producing high levels of alcohol during fermentation of plant material, and to the high alcohol beer produced. The present invention also relates to methods for producing high protein distiller's dried grain from fermentation of plant material, and to the high protein distiller's dried... Agent: Swiss Tanner, P.C. P.o. Box 1749

20100041117 - Process for producing ethanol and for energy recovery: The present invention is directed to a process for the production of ethanol and energy. The process includes the steps of fermenting a corn mash in an aqueous medium to produce a beer. Next, the beer is distilled to produce ethanol and a whole stillage. The whole stillage is anaerobically... Agent: James P. Hanrath

20100041118 - Process for the continuous production of ethanol: A process for the production of ethanol utilizes a vacuum process and selectively permeable membranes to increase ethanol production efficiency. Yeast converts sugars to ethanol in an anaerobic condition within process chamber void of oxygen and filled with a Nitrogen gas (N2) or any non-oxygen containing gas. A glucose solution... Agent: John M. Siragusa Carlson, Gaskey & Olds, P.C.

20100041119 - Method and apparatus for conversion of cellulosic material to ethanol: p

20100041120 - Botryoccocus braunii triterpene synthase proteins and nucleic acid molecules, and methods for their use: This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are host cells comprising the nucleic acid molecules of this invention, proteins encoded by the nucleic acid molecules and methods for using the nucleic acid molecules,... Agent: Crowell & Moring LLP Intellectual Property Group

20100041121 - Metabolically engineered organisms for the production of hydrogen and hydrogenase: The present application relates to the use of metabolically-engineered microbial cells for the production of hydrogen and hydrogenase enzymes. The microbial cells are strains of E. coli which are genetically engineered to optimize the cell for production of hydrogen or active hydrogenase. The strains of E. coli are transformed with... Agent: Knobbe Martens Olson & Bear LLP

20100041122 - Centrifugal force-based system for detection/treatment of membrane-encased structures: Membrane-encased structures such as biological cells, liposomes, and vesicles, are conveyed through one or more channels in a rotating disk for individual exposure to optical elements or to electrodes, for purposes of transfection or flow cytometry. The rotation of the disk serves either to provide centrifugal force to urge the... Agent: Townsend And Townsend And Crew, LLP

20100041123 - Immobilized enzymes and uses thereof: Disclosed are bioanodes comprising a quaternary ammonium treated Nafion® polymer membrane and a dehydrogenase incorporated within the treated Nafion® polymer. The dehydrogenase catalyzes the oxidation of an organic fuel and reduces an adenine dinucleotide. The ion conducting polymer membrane lies juxtaposed to a polymethylene green redox polymer membrane, which serves... Agent: Senniger Powers LLP

20100041124 - Multi-stage cstr bioreactor system equipped with cell recycle unit: The present invention relates to a single CSTR bioreactor equipped with a cell recycle unit, and a multi-stage CSTR bioreactor system in which 2-7 such single CSTR bioreactors are connected in series with each other. According to the present invention, multi-stage fermentation is carried out in the bioreactor equipped with... Agent: Moore & Van Allen PLLC

20100041125 - Method for recovering oil from plant seeds: The invention relates to a method for recovering of oil from plant seeds characterized in that a) an aqueous solution containing one or more cellulolytic and/or lipolytic and/or pectinolytic and/or proteolytic enzyme(s) and/or phytase is sprayed onto the seed, b) the thus obtained seed is directly supplied to a one-stage... Agent: Edwards Angell Palmer & Dodge LLP

20100041126 - Methods for diagnosing and treating prostate cancer: Devices and methods for diagnosing and treating prostate cancer are disclosed. In practicing the method, a subject's body-fluid sample is assayed for GPC3 protein, and the GPC3 level observed is used in determining whether the subject has an elevated GPC3 level associated with prostate cancer. Patients with such elevated levels... Agent: King & Spalding LLP

20100041127 - Preparation and use of a reactive solid support surface: A method of preparing a protein-resistant reactive solid support surface is disclosed. The method comprises the steps of providing a solid support having a hydrogel coating with a plurality of binding elements, coupling a protein resistant compound to the hydrogel via a first fraction of the binding elements, and coupling... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100041128 - Microfluidic device for application of shear stress and tensile strain: The present invention provides a cell culture device for applying shear stress and strain on single cells. The device includes at least one channel, at least one cell culture chamber having at least one single-cell attachment surface, a flexible membrane, at least one vacuum channel, and an inlet and an... Agent: The Webb Law Firm, P.C.

20100041129 - Device and system for the installation of an air filtration system in an existing incubator: An improved air purification system is added to an existing incubator or environmental chamber. The improved air purification system includes a series of parts, such as a plate, motor box, power connections and filter to be retrofitted and/or installed into an available interior space of the incubator. The system increases... Agent: William W. Jones

20100041130 - Bioreactor for producing synfuel from carbonaceous material: A bioreactor for producing synfuel from carbonaceous material includes a stacked particle heap comprising biodegradable carbonaceous material, an aerobic microbial consortium fermenting the biodegradable carbonaceous material into synfuel, and a gas impermeable barrier operatively covering the stacked particle heap. The covered particle heap is purged with at least one non-oxygenated... Agent: Dickstein Shapiro LLP

20100041131 - Blood specimen dispenser: A blood specimen dispenser is provided which dispenses a precise amount of collected blood from a blood specimen collector onto filter paper or the like for screening or evaluation.... Agent: Thomte Law Office, L.L.C.

20100041133 - Biological targeting compositions and methods of using the same: Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the... Agent: Searete LLC Clarence T. Tegreene

20100041132 - Bioreactor system: In one aspect the invention provides a bioreactor system for the production of tissue prostheses. The system includes a bioreactor, a culture medium reservoir coupled to the bioreactor by a first conduit and a second conduit, a pump operable to pump fluid into and draw fluid out of a pumping... Agent: Drinker, Biddle & Reath

20100041135 - Gastric submucosal tissue as a novel diagnostic tool: A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing fastidious organisms is described. Submucosal tissue used in accordance with the present invention supports the proliferation of cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.... Agent: Barnes & Thornburg LLP

20100041134 - Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same: Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and... Agent: Senniger Powers LLP

20100041136 - Connective tissue growth factor-2: The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for enhancing the repair of connective and... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20100041137 - Culture medium containing kinase inhibitors, and uses thereof: Pluripotent cells are maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and, optionally, an antagonist of an FGF receptor. Pluripotent cells are also maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor and an antagonist of an FGF... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100041138 - Il-17 homologous polypeptides and therapeutic uses thereof: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Arnold & Porter LLP (24126) Attn:IPDocketing Dept.

20100041139 - Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof: Polynucleotide and polypeptide sequences for HFE2A, as well as mutations associated with juvenile hemochromatosis, and methods of utilizing these for the screening and identification of agents for the treatment of diseases of iron metabolism, including small organic compounds, are disclosed along with methods of treating and/or ameliorating diseases of iron... Agent: Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein

20100041140 - Nucleic acid compounds for inhibiting bcl2 gene expression and uses thereof: The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing BCL2 gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-over-lapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.

20100041141 - Methods and compositions relating to improved lentiviral vectors and their applications: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise a self-inactivating configuration for biosaftey and promoters such as the... Agent: Fulbright & Jaworski, L.L.P.

20100041142 - Anti-apoptotic gene scc-s2 and diagnostic and therapeutic uses thereof: A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-S2 such as renal, ovarian, head and neck, breast, prostate, brain, chronic myelogenous... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20100041143 - Holding petri dish, microinjection apparatus, and microinjection method: A holding petri dish used for a process of microinjection for introducing an introduced substance into an introduced-substance receiving body includes a well provided on a transparent material and a channel including an opening for holding the introduced-substance receiving body via suction, said opening being disposed on a side wall... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20100041144 - Mammalian cytokine; related reagents: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering-plough Biopharma Legal Department

20100041145 - Tolerogenic dendritic cells, method for their production and uses therof: The present invention relates to a tolerogenic dendritic cell population (Tr-DC) capable of generating a population of T cells having regulatory activity, method of production and uses thereof. Furthermore, soluble HLA-G promotes the differentiation of a population of T cells with regulatory activity.... Agent: The Law Office Of Kenneth K. Sharpes Sena Plaza Building, Suite 54, 2nd Floor

20100041146 - Three-dimensional cell culture carrier and method for cell culture using the same: A three-dimensional cell culture carrier of the present invention includes a fibrous structure having a three-dimensional space for cell culture. The fibrous structure is formed of a plurality of intertangled fibers. Each of the fibers used in the fibrous structure is made of a material having a visible light transmittance... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20100041147 - Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation: Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.... Agent: Lewis J. Kreisler Wellstat Management Company, LLC

20100041149 - Bioreactor and method for generating cartilage tissue constructs: A bioreactor includes a housing and a support mechanism for suspending the housing above the bottom surface of a culture vessel. The housing includes a member having oppositely disposed first and second surfaces and an inner surface defining an opening. The opening extends between the first and second surfaces of... Agent: Tarolli, Sundheim, Covell & Tummino, LLP

20100041150 - Expansion of definitive endoderm cells: Disclosed herein are cell cultures comprising expanded definitive endoderm cells as well as methods for expanding definitive endoderm cells in culture.... Agent: Knobbe Martens Olson & Bear LLP

20100041148 - Process and support structure for the cultivation of living cells: In a process for the cultivation of living cells, in which the cells are cultivated on a support structure (14), the support structure (14) comprises cellulose. A process for the production of a support structure (14) of cellulose for the cultivation of living cells comprises the steps: preparation of a... Agent: Marjama Muldoon Blasiak & Sullivan LLP

20100041151 - Compositions and methods for treating lysosomal storage disease: The present invention provides recombinant viral and non-viral vectors comprising a transgene encoding a biologically active human lysosomal enzyme that are able to infect and/or transfect and sustain expression of the biologically active human lysosomal enzyme transgene in mammalian cells deficient therein. In addition, methods are provided for providing a... Agent: Genzyme Corporation Legal Department

20100041152 - Methods for encapsulating plasmids in lipid bilayers: Plasmid-lipid particles which are useful for transfection of cells in vitro or in vivo are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. The particles are typically 65-85 nm, fully encapsulate the plasmid and are serum-stable.... Agent: Seed Intellectual Property Law Group PLLC

20100041153 - Expression of proteins in e. coli: Plasmid comprising a DNA tag encoding a peptide tag of the sequence MX1(X 2X 3) n X 1 represents K or R; X 2 represents M, S or T; X 3 represents K or R; n represents an integer of 1 or larger; and wherein said DNA is operably-linked to... Agent: Novo Nordisk, Inc. Intellectual Property Department

  
02/11/2010 > patent applications in patent subcategories. patent applications/inventions, industry category

20100035231 - Antigen capture anti-dengue iga elisa (aca-elisa) for the detection of a flavivirus specific antibody: An antigen capture IgA Enzyme Linked Immunosorbent Assay (ACA-ELISA) was developed for the detection of anti-flavivirus IgA. The assay utilizes flavivirus lysate antigen, preferably dengue virus lysate antigen captured by a monoclonal antibody. Captured anti-flavivirus IgA from test sera are preferably detected using rabbit anti-IgA conjugated with a reporter group... Agent: Knobbe Martens Olson & Bear LLP

20100035227 - Compositions for use in identification of alphaviruses: The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of alphaviruses by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Casimir Jones, S.c.

20100035236 - Enrichment method for variant proteins with altered binding properties: A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous... Agent: Genentech, Inc.

20100035230 - Methods and agents for detecting parechovirus: The present disclosure provides methods that permit detection of all known species of Parechovirus, including Human parechovirus and Ljungan virus (LV). In particular examples the method includes amplifying at least a portion of the 5′NTR of parechovirus nucleic acid molecules obtained from a sample, and detecting the resulting amplicons, but... Agent: Klarquist Sparkman, LLP

20100035229 - Methods, plasmid vectors and primers for assessing hiv viral fitness: The present invention relates to methods and means for the evaluation of HIV replicative capacity in a given environment. In particular, the invention provides a growth competition assay that can determine relative viral fitness using a recombinant tagged HIV-1 virus system. The methods rely on plasmid vectors, amplicons, primers and... Agent: Philip S. Johnson Johnson & Johnson

20100035228 - Monitored separation device: e

20100035237 - Novel antigen constructs useful in the detection and differentiation of antibodies to hiv: Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences... Agent: Abbott Laboratories C/o Polsinelli Shughart PC

20100035232 - Targeted whole genome amplification method for identification of pathogens: The methods disclosed herein relate to methods and compositions for amplifying nucleic acid sequences, more specifically, from nucleic acid sequences of pathogens by targeted whole genome amplification.... Agent: Casimir Jones, S.c.

20100035233 - Triggered rnai: The present application relates to methods and compositions for triggering RNAi. Triggered RNAi is highly versatile because the silencing targets are independent of the detection targets. In some embodiments, methods of silencing or modulating the expression of a marker gene are provided. The methods generally comprise providing an initiator to... Agent: Knobbe Martens Olson & Bear LLP

20100035235 - Use of focused light scattering techniques in biological applications: Methods for using focused light scattering techniques for the optical sensing of biological particles suspended in a liquid medium are disclosed. The optical sensing enables one to characterize particles size and/or distribution in a given sample. This, in turn, allows one to identify the biological particles, determine their relative particle... Agent: Intellectual Property / Technology Law

20100035234 - Vaccine assays: The present invention is directed to methods, assays and compositions for implementing such methods and assays for assessing efficacy of individual components in multi-component vaccines and for assessing efficacy of a vaccine against a pathogen. In one aspect, the method of assessing efficacy of a vaccine against a pathogen is... Agent: Novartis Vaccines And Diagnostics Inc.

20100035245 - Analyte test system using non-enzymatic analyte recognition elements: An analyte test element for the qualitative and/or quantitative determination of at least one analyte in a physiological or aqueous sample fluid having a first surface (2a) and a second surface (4a) in a predetermined distance opposite from each other, said both surfaces are provided with two substantially equivalent patterns... Agent: Morgan Lewis & Bockius LLP

20100035238 - Anti-freeze protein enhanced nucleic acid amplification: Methods and compositions are provided for enhanced signal intensity and storage stability of standard nucleic acid amplification buffers, real-time PCR buffers or both. Buffers in accordance with the present invention include anti-freeze protein(s) (AFPs), optionally with a carrier protein, such as BSA.... Agent: Dorsey & Whitney LLP Intellectual Property Department

20100035258 - Assay and method: The present invention relates to a method and assay useful for determining the sensitivity of the cells of a subject to genetic damage from electromagnetic radiation. The assay may comprise a substrate suitable for mounting a sample of lymphocytes from a subject and an electromagnetic radiation source.... Agent: Myers Bigel Sibley & Sajovec

20100035259 - Biomarkers and methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators: VEGFR-2 biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an VEGFR-2 modulator, wherein the method comprises (a) exposing the mammal to the VEGFR-2 modulator and (b) measuring in the mammal the level of the at... Agent: Louis J. Wille Bristol-myers Squibb Company

20100035265 - Biomarkers for drug-induced liver injury: The present invention provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly Drug-Induced Liver Injury (DILI) or hepatotoxicity. The invention also provides a method of identifying a subject afflicted with, or at risk of, developing DILI. In some aspects, the methods comprise analyzing... Agent: Wilmerhale/dc

20100035263 - Biomarkers for renal disease: The invention provides methods and kits for diagnosing a renal disease in a patient or for predicting the risk of a patient for developing a renal disease. In one embodiment, the invention provides a method for diagnosing a renal disease in a patient, comprising determining the level of a ubiquitin... Agent: Whiteford, Taylor & Preston, LLP Attn: Gregory M Stone

20100035251 - Biomarkers for the progression of alzheimer's disease: The genetic polymorphism LRRK2 (leucine-rich repeat kinase 2)-T1602S is significantly associated with conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), with the patients with TT genotype being at greater risk to progress to Alzheimer's disease. The LRRK2-T2352 also showed a trend for conversion to Alzheimer's disease, with the... Agent: Novartis Institutes For Biomedical Research, Inc.

20100035254 - Composition and method for nucleic acid sequencing: The present invention provides compositions and methods for detecting incorporation of a labeled nucleotide triphosphate onto the growing end of a primer nucleic acid molecule. The method is used, for example, to genotype and sequence a nucleic acid. In a preferred embodiment, the method described herein detects individual NTP molecules.... Agent: Townsend And Townsend And Crew, LLP

20100035239 - Compositions for use in identification of bacteria: The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of bacteria by amplification of a segment of bacterial nucleic acid followed by molecular mass analysis.... Agent: Casimir Jones, S.c.

20100035260 - Compositions, devices, systems, for using a nanopore: The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine... Agent: Bell & Associates

20100035267 - Detection of individual t-cell reaction patterns against tumor-associated antigens (taa) in tumor patients as a basis for the individual therapeutic vaccination of patients: The present invention relates to a method for identifying the preferential target antigens of antitumoural T-cells of a tumour patient, comprising: a) providing T-cells from the blood of at least one tumour patient, b) providing dendritic cell (DCs) and/or B-lymphocytes (BLCs) that are autologous for said tumour patient, wherein said... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20100035272 - Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives: Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they do not require any chemical reaction on the probes or on the analytes since they are based on different electrostatic interactions between cationic poly(3-alkoxy-4-methylthiophene) derivatives and... Agent: Knobbe Martens Olson & Bear LLP

20100035244 - Diagnostic for lung disorders using class prediction: The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis with bronchoscopy. The methods of the invention provide far superior detection accuracy for lung cancer when compared to any other currently available... Agent: Morse, Barnes-brown & Pendleton, P.C. Attn:IPManager

20100035256 - Enduracidin biosynthetic gene cluster from streptomyces fungicidicus: This disclosure describes the molecular cloning of an enduracidin biosynthetic gene cluster from Streptomyces fungicidicus, and characterization of individual genes in the gene cluster and the proteins encoded thereby. An enduracidin gene cluster is located within a 116 kilobases genetic locus and includes 25 open reading frames (ORFs). An additional... Agent: Klarquist Sparkman, LLP

20100035247 - Heterogeneous assay of analytes in solution using polymers: The invention relates to methods and systems for identifying, quantitating and/or analyzing analytes from samples. The analytes may be organic or inorganic in nature and include but are not limited to pathogens such as viruses.... Agent: Wolf Greenfield & Sacks, P.C.

20100035241 - Isolation of allergen-specific immunoglobulin genes from human b-cells from atopy sufferers: A process is disclosed which enables the establishing of comprehensive immunoglobulin-specific reaction profiles of subjects with disorders of the immune function by the individual V gene repertoire of Ig-expressing B cells. The process comprises the isolation of B cells from body fluids, the isolation of individual B cells and their... Agent: Dardi & Associates, PLLC

20100035268 - Materials and methods for single molecule nucleic acid sequencing: Provided herein are methods and compositions for real time single molecule sequencing of short nucleotide sequences using nucleotide fluorescent semiconductor nanocrystals-conjugated nucleotide primers.... Agent: Life Technologies Corporation C/o Intellevate

20100035255 - Method and kit for assessing risk of gout and hyperuricemia: A method for assessing a risk of suffering from a gout of a subject is provided. The method includes steps of obtaining a nucleotide sample from the subject; determining a genetic polymorphism of one of a Urate transporter 1 (URAT1) gene and an alpha-kinase 1 (ALPK1) gene in the nucleotide... Agent: Volpe And Koenig, P.C.

20100035262 - Method for detecting thyroid carcinoma: It is an object of the present invention to identify a gene that exhibits behavior which is characteristic of carcinomas such as thyroid carcinoma, so as to provide a method for detecting carcinoma and a cell growth suppressing agent. The present invention provides a method for detecting carcinoma, which comprises... Agent: Birch Stewart Kolasch & Birch

20100035261 - Method of detecting large genomic rearrangements: A method for detecting large genomic rearrangements is disclosed, which is particularly useful in detecting deletions and duplications in the large genes such as BRCA1, BRCA2, MLH1 and MSH2.... Agent: Myriad Genetics Inc. Intellectual Property Department

20100035253 - Methods and compositions for incorporating nucleotides: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that... Agent: Peter G. Carroll Medlen & Carroll, LLP

20100035270 - Methods and compositions for the detection of bovine pregnancy: Provided herein are pregnancy specific marker genes, such as those shown in Tables I-III, and methods of detecting the same to determine bovine pregnancy.... Agent: Dann, Dorfman, Herrell & Skillman

20100035240 - Methods and kit for the prognosis of breast cancer: The present invention relates to a method and kit, including parts thereof, for the prognosis of breast cancer. In particular, the method involves identifying a gene expression pattern, or molecular signature, that indicates the likelihood of survival of a patient with breast cancer, and/or likelihood of recurrence of the disease... Agent: King & Schickli, PLLC

20100035246 - Methods and kits for analyzing genetic material of a fetus: A non-invasive method of analyzing a genetic material of a fetus is provided. The method is achieved by detecting a cell-free nucleus in a sample such as a transcervical specimen obtained from a pregnant woman and/or detecting in a cell-free nucleus at least one fetal-nucleus specific marker thereby identifying a... Agent: The Nath Law Group

20100035242 - Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders: The invention provides methods, nucleic acids and kits for detecting metastasis of colon cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of metastasis of colon cell proliferative disorders, thereby enabling the improved diagnosis and treatment of patients.... Agent: Davis Wright Tremaine, LLP/seattle

20100035264 - Methods and vectors for producing transgenic plants: Methods of, and compositions for, assembling one or more transcription units in a genome without a linked selectable marker or other unwanted transcription unit are provided. Also provided methods of, and compositions for, assembling one or more transcription units in a genome with a reduced frequency of vector backbone.... Agent: Arnold & Porter LLP

20100035266 - Methods for assessing risk of alzheimer's disease in a patient: Disclosed are methods for diagnosis or prognosis of Alzheimer's disease in a patient. The methods may include assessing whether a patient has Alzheimer's disease or assessing a patient's risk for developing Alzheimer's disease. The methods typically include determining, either directly or indirectly, whether the patient has mutations, such as single... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100035252 - Methods for sequencing individual nucleic acids under tension: The invention provides apparatuses and methods of use thereof for sequencing nucleic acids subjected to a force, and thus considered under tension. The methods may employ but are not dependent upon incorporation of extrinsically detectably labeled nucleotides.... Agent: Ion Torrent Systems Incorporated C/o Wolf, Greenfield & Sacks, P.C.

20100035257 - Methods to determine the responsiveness to cisplatin treatment: The present invention relates, generally, to methods to identity subjects responsive to p73/p63 targeting agents such as platinum-based chemotherapy agents such as, but not limited to, cisplatin and cisplatin derivatives and analogues thereof. More particularly, the present invention relates to methods to identify a cancer responsive to a p73/p63 targeting... Agent: David S. Resnick

20100035271 - Modification of collagenous materials and medical treatment, diagnosis and monitoring of fibrotic conditions: In one aspect, the invention provides methods and compositions to prepare collagenous materials with varying biodegradation rates by varying the ratio of hydroxyallysine cross-links over allysine cross-links. In another aspect, the invention provides methods and compositions to lower the ratio of hydroxyallysine cross-links over allysine cross-links in fibrotic processes, in... Agent: Londa, Bruce S. Norris Mclaughlin & Marcus, Pa

20100035269 - Prevention and alleviation of steric hindrance during single molecule synthesis: The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-DNA glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved)... Agent: Pacific Biosciences Of California, Inc.

20100035249 - Rna sequencing and analysis using solid support: The present invention provides methods for the sequencing of all RNA species within an RNA sample, such as the RNA content obtained from a cell, a tissue, a living organism, or from an artificial source. RNA molecules within the samples are labeled in a RNA-specific manner prior to immobilization on... Agent: Foley And Lardner LLP Suite 500

20100035248 - Surface-based nucleic acid assays employing morpholinos: The sequence determination, detection, and quantification of nucleic acid molecules through sequence-specific binding (hybridization) on a solid support, specifically when Morpholinos are used as the surface-immobilized probe species in surface-based nucleic acid assays, and the assays as disclosed herein.... Agent: Smith, Gambrell & Russell

20100035243 - Ultra-sensitive detection of analytes: The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to methods that utilize nanoparticle probes in an in-solution homogeneous assay system for high-sensitivity detection of... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100035250 - Use of phenanthridium derivatives for distinguishing between intact and membrane compromised cells using molecular nucleic acid-based techniques: The present invention provides novel chemicals and methods for selectively excluding DNA of dead cells from a mixture containing live and dead cells from molecular detection.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100035275 - Diagnosis and risk assessment of pancreatic diabetes using mr-proadm: The invention relates to a method for diagnosis and/or risk assessment of pancreatic diabetes, in particular of diabetic sequelae, wherein a determination of the marker mid-regional proAdrenomedullin (MR-proADM: SEQ ID No. 2) or a partial peptide or fragment thereof or if contained in a marker combination (Panel, Cluster) is carried... Agent: Connolly Bove Lodge & Hutz, LLP

20100035276 - Identifying virally infected and vaccinated organisms: This document provides methods and materials related to assessing organisms for the presence or absence of anti-virus antibodies. For example, this document provides methods and materials that can be used to determine whether or not an organism (e.g., a member of a swine species such as a pig) contains anti-PRRS... Agent: Fish & Richardson P.C.

20100035273 - Method and device for small scale reactions: The present invention relates to a method and a device for small scale reactions, such as sample preparation of a desired substance in a sample. In the method using the device samples mixed with functionalized magnetic particles are magnetically transferred between different working stations on the device. The method uses... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100035274 - Methods for detecting symmetrical dimethylarginine: Method of detecting Symmetrical dimethyl arginine (SDMA) in biological samples. SDMA analogs for generating anti-SDMA antibodies having little or no cross-reactivity with asymmetrical dimethyl arginine, arginine, and monomethylarginine. The analogs have a protected or free thiol (—SH) group or hydroxyl (—OH) group that allow them to be linked to a... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100035278 - Biological substance analysis chip, biological substance analysis kit and method of biological substance analysis using them: The present invention provides a biological substance analysis chip capable of quantitative measurement in a minute region through immobilization of a biological substance trapping probe to a substrate surface in a more uniform density, a biological substance analysis kit that uses said chip, and a biological substance analysis method that... Agent: Sughrue Mion, PLLC

20100035277 - Method and apparatus for determining the cell activation of a target cell by an activator: The invention relates to a method and a device for determining the cell activation of a target cell by an activator, said method having the following steps: provision of a probe measuring device with a probe sample arrangement having a measuring probe and a sample holder; loading of the probe... Agent: Smith Patent Office

20100035280 - Chimeric fc-gamma receptor and method for determination of adcc activity by using the receptor: To accomplish the above-mentioned objectives, the present inventors produced chimeric molecules by fusing the extracellular domain of mouse FcγR3 or mouse FcγR4 with the transmembrane domain/intracellular domain of human γ chain or human FcγR3, and expressed the chimeric molecules in human NK92 cells. It was revealed that the ADCC activity... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100035279 - Fluorescent substrates for monoamine transporters as optical false neurotransmitters: The present invention relates to compounds of the general structure: wherein Y is O, X is O, bond α is absent and bond β is present, or Y is H, X is CH, bond α is present, and bond β is absent; atom Z is a carbon and bonds χ,... Agent: Cooper & Dunham, LLP

20100035281 - Compositions and methods for tissue-based protein truncation test for disease diagnosis: Embodiments herein concern methods and compositions for diagnosing or predicting the onset of a genetic disorder In certain embodiments, the methods may include use of a rapid and inexpensive assay. In other embodiments, the assay utilizes a tissue sample from a subject to identify the state of a target protein... Agent: Faegre & Benson LLP Patent Docketing - Intellectual Property

20100035283 - Preparation method: A method of performing an immunologic evaluation of a subject, comprising collecting a whole blood sample from the subject, maintaining the sample for at least 6 hours after the collection, purifying a population of cells comprising lymphocytes and antigen presenting cells from the maintained sample, optionally by a process incorporating... Agent: Baker Botts L.L.P.

20100035282 - Use of common gamma chain cytokines for the visualization, isolation and genetic modification of memory t lymphocytes: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.... Agent: The Law Office Of Kenneth K. Sharples Sena Plaza Building Suite 54 Second Floor

20100035285 - Rapid elisa: A step in the enzyme-linked immunosorbent assay (ELISA) is changed from a heterogeneous phase to a homogeneous phase, to give a much shorter overall completion time. The new assay comprises the steps of (i) mixing in a homogeneous phase a sample and a first binding partner to an analyte to... Agent: Novartis Vaccines And Diagnostics Inc.

20100035284 - Urinary proteomic biomarker patterns in preeclampsia: The invention relates, in part, to methods of using proteomic biomarkers to diagnose preeclampsia. In some aspects the invention, in part, relates to the detection of serpina-1 polypeptide and/or albumin polypeptide in samples from pregnant subjects. Samples from subjects may be compared to control samples to diagnose preeclampsia and/or to... Agent: Wolf Greenfield & Sacks, P.C.

20100035286 - In vitro method for the diagnosis and early diagnosis of neurodegenerative disorders: In vitro method for the detection and early detection of, for the determination of the degree of severity of, and for the assessment of the course of and prognosis of neurodegenerative disorders, in which an immunodiagnostic determination method is used to determine the apolipoprotein C-1 (Apo C-1) immunoreactivity in a... Agent: Heslin Rothenberg Farley & Mesiti PC

20100035287 - Secreted luciferase fluorescent protein conjugate nucleic acid construct and uses thereof: The present invention relates generally to methods to monitor the transport of proteins through the secretory pathway, and methods to monitor ER stress. In particular, the present invention relates to methods to monitor, in real-time, the processing of protein through the secretory pathway, which can be monitored both at a... Agent: David S. Resnick

20100035288 - Reagent for quantitative determination of small, dense ldls: A reagent for fractional measurement of small, dense LDLs without pretreatment of a specimen, which is adaptable to a rapid and convenient autoanalyzer, is provided. A method for quantitatively determining cholesterol in small, dense LDLs in a sample is further provided, comprising: a first step of eliminating lipoproteins other than... Agent: Foley And Lardner LLP Suite 500

20100035289 - Diagnosis and risk stratification by means of the novel marker ct-proadm: The invention relates to a novel diagnostic marker CT-proADM (C-terminal fragment of preproADM, SEQ ID No, 1) for diagnosing and/or stratifying the risk of diseases. Also disclosed is a method for diagnosing and/or stratifying the risk of diseases, particularly cardiovascular diseases, cardiac insufficiency, and infections and/or inflammations of the lungs... Agent: Connolly Bove Lodge & Hutz, LLP

20100035290 - Enzyme detection system with caged substrates: An enzyme detection method includes forming a caged substrate; releasing an uncaged substrate by cleaving a caging molecules from the caged substrate; and emitting a light emission from a Bioluminescence Resonance Energy Transfer luminescent nanocrystal conjugate reacting with the uncaged substrate.... Agent: Law Offices Of Mikio Ishimaru

20100035291 - Method for degrading peptides, method for analyzing peptides, device for degrading peptides and device for analyzing peptides: A fragmenting reaction of peptide is achieved while maintaining the isolated state of peptide. Isolated peptide fractions isolated by electrophoresis are prepared in flow paths. Subsequently, prepared peptide fractions are dried by each of the flow paths. Then, dried peptide fractions are in contact with protease. Then, independent liquid membranes... Agent: Sughrue Mion, PLLC

20100035296 - Compounds and methods for detection of cells: The invention relates to compounds comprising an ester group for the detection in vivo of cells undergoing cell death (“dying cells”) such as, for example, cells undergoing apoptosis. These compounds are selectively retained in dying cells relative to normal cells. Thus, the compounds may be used in the detection, diagnosis... Agent: Pearl Cohen Zedek Latzer, LLP

20100035298 - Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids: A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function... Agent: Loeb & Loeb, LLP

20100035297 - Methods and compositions for vasculogenic potential determination: Methods and compositions to evaluate the therapeutic vasculogenic potential of a variety of cells including endothelial cells using a monolayer of pericytic cells are disclosed. Pericytic cells or mural cells including those isolated from adipose tissue, such as for example, adipose stromal cells (ASC) or adipose-derived stromal cells (ADSCs) provide... Agent: Barnes & Thornburg LLP

20100035292 - Microfluidic device for high-throughput cellular gradient and dose response studies: The ability to form and maintain gradients is essential for the study of response of cells to various stimuli. The invention includes devices and methods for the high-throughput, reproducible formation of gradients for the study of living cells. The invention includes microfluidics device with a test chamber having a depth... Agent: Edwards Angell Palmer & Dodge LLP

20100035293 - Pulsing of bile compartments in sandwich-cultured hepatocytes: A method of pulsing cultured hepatocytes, such as sandwich-cultured hepatocytes. The method includes providing a culture of hepatocytes, the culture having at least one bile canaliculus; exposing the culture of hepatocytes to a calcium-free buffer, whereby the contents of the at least one bile canaliculus are released; and removing the... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20100035294 - System to assess the biological activity of chemoattractants: The present invention relates to a system for measuring the biological activity of chemoattractants comprising at least two units separated by a semipermeable carrier wherein biologically active carbohydrate structures, preferably glycosaminoglycan (GAG) structures, are immobilized on the surface of said carrier. According to the invention, this system can be used... Agent: Proskauer Rose LLP

20100035295 - Systems to analyze cellular metabolism and cell and molecular reactions: The present invention relates to systems capable of measuring an electrical signal produced by a cell, for example, by the metabolic activity of a cell. A system of the invention relates to varying the applied voltage and frequency to a culture vessel containing cells to account for the differences in... Agent: Patricia J. Malin

20100035299 - Methods for the purification of polypeptide conjugates: The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an... Agent: Novo Nordisk, Inc. Intellectual Property Department

20100035301 - Beta-mannanase from coffee berry borer, hypothenemus hampei, and uses thereof: The present invention relates to an isolated β-mannanase protein having an amino acid sequence which is 90% similar to the amino acid sequence of SEQ ID NO:1, as well as isolated polynucleotides encoding the β-mannanase protein, and isolated expression systems and host cells containing the polynucleotides. The present invention also... Agent: Nixon Peabody LLP - Patent Group

20100035300 - Producing a target protein using intramolecular cleavage by tev protease: A cis-TEVP fusion protein including a TEVP protease, a TEVP cleavage site and a target protein provide a platform for expression of the target protein. A trans-TEVP fusion protein including a TEVP cleavage site and a target protein, the amino-terminal portion of the target protein adjacent to the C-terminal portion... Agent: Luce, Forward, Hamilton & Scripps LLP

20100035302 - Method for making soluble arabinoxylans as co-product of fermentation of whole-grain cereals: The present invention provides a method for producing preparations comprising soluble arabinoxylans as co-products of ethanol production through fermentation of whole-grain cereals. The method results in preparations that are highly enriched in soluble arabinoxylans, which can be used as a food, beverage, or feed ingredients.... Agent: Clark & Elbing LLP

20100035303 - Method of amplifying target nucleic acid sequence by multiple displacement amplification including thermal cycling: A method of amplifying a target nucleic acid sequence includes multiple displacement amplification and thermal cycling. According to the method, the target nucleic acid sequence may be effectively amplified.... Agent: F. Chau & Associates, LLC

20100035304 - Method of producing a mash extract and an apparatus for carrying out such method: m

20100035306 - Fermentation of pentose sugars: The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the host cell the ability to convert xylose to xylulose which may be further metabolized by the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20100035305 - Method of producing amino acid metal chelates: A method of producing amino acid metal chelates includes producing an amino acid ligand by enzymatically hydrolyzing bacterial cells, and reacting the amino acid ligand with a metal cation.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100035307 - Methionine synthases with reduced product inhibition: The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host... Agent: Smith, Gambrell & Russell

20100035308 - Method of preparing a controlled release fertilizer: Methods of preparing a controlled release fertilizer include obtaining an amino acid fermentation byproduct liquor, and converting ammonium in the amino acid fermentation byproduct liquor to magnesium ammonium phosphate to obtain the controlled release fertilizer.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100035309 - Analysis and enhancement of metabolic pathways for methanogenesis: Processes for biogenic production of a hydrogen-carbon-containing fluid from a hydrocarbon containing formation are described. The processes may include providing in the formation an anaerobic microorganism consortium containing one or more enzymes to activate a starting hydrocarbon by an addition of a chemical group to the hydrocarbon. The processes may... Agent: Townsend And Townsend And Crew, LLP

20100035310 - Production of functional proteins: balance of shear stress and gravity: A method for the production of functional proteins including hormones by renal cells in a three dimensional culturing process responsive to shear stress uses a rotating wall vessel. Natural mixture of renal cells expresses the enzyme 1-α-hydroxylase which can be used to generate the active form of vitamin D: 1,25-diOH... Agent: James M. Cate Nasa Johnson Space Center

20100035311 - Method and composition for enzyme storage: We describe the detailed production, biochemical characterisation and storage of CYP74 enzymes, including CYP74C3, a recombinant plant cytochrome P450 enzyme with hydroperoxide lyase (HPL) activity from Medicago truncatula, and CYP74A1, an Allene Oxide Synthase (AOS), from Arabidopsis thaliana. Steady state kinetic parameters, substrate and product specificities, Rz, extinction coefficient, haem... Agent: Michael Best & Friedrich LLP

20100035312 - Immobilized interfacial enzymes of improved and stabilized activity: Disclosed is a process for the preparation of an interfacial enzyme immobilized on an insoluble support, by providing a bi-phase system comprised of an aqueous buffer solution and at least one first organic solvent; mixing said interfacial enzyme with the bi-phase system provided; adding the support to the obtained mixture... Agent: David S. Resnick

20100035313 - Microorganism capable of producing polyhydroxyalkanoate, polyhydroxyalkanoate synthase, and gene encoding the same: Solution: The new microorganism is capable of producing a polyhydroxyalkanoate comprising a 16S rRNA gene whose polynucleotide sequence shows 99% or more homology to a polynucleotide sequence represented by SEQ ID No: 1, having an optimum temperature of an activity temperature range for the growth and PHA production of the... Agent: Quinn Emanuel Urquhart Oliver & Hedges, LLP Koda/androlia

20100035314 - Method for the enzymatic production of 2-hydroxy-2-methyl carboxylic acids: The present invention relates to a method for the enzymatic production of 2-hydroxy-2-methyl carboxylic acids from 3-hydroxy carboxylic acids, where a 3-hydroxy carboxylic acid is produced in an aqueous reaction solution and/or is added to this reaction solution and is incubated. The aqueous reaction solution comprises a unit having 3-hydroxy-carboxylate-CoA... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100035315 - Process for enzymatic reduction of alkene derivatives: A method for enzymatic preparation of compounds of the general formula (2) from unsaturated alkene derivatives of the general formula (1) by reducing a compound of the formula (1) in the presence of a reductase, comprising at least one of the polypeptide sequences SEQ ID NO: 1, 2 or 3... Agent: Connolly Bove Lodge & Hutz, LLP

20100035316 - Method of brewing ethanol: A method of brewing alcohol, comprising at least the following steps: a grinding step of materials: grinding a mixture of the materials and water to obtain a mash containing material residues; a mixture-preparing step: mixing the mash containing material residues with yeast; a fermentation step: fermenting the mash containing material... Agent: Rosenberg, Klein & Lee

20100035317 - Novel alcohol dehydrogenase, gene for the alcohol dehydrogenase, vector, transformant, and method for production of optically active alcohol by using them: An object of the present invention is to provide a novel alcohol dehydrogenase, a gene for the alcohol dehydrogenase, a vector including the gene, a transformant transformed with the vector, and a method for producing an optically active alcohol by utilizing them. A feature of the present invention directs to... Agent: Connolly Bove Lodge & Hutz LLP

20100035318 - Process for the fermentative production of ethanol from solid lignocellulosic material comprising a step of treating a solid lignocellulosic material with alkaline solution in order to remove the lignin: The present invention relates to a process for obtaining fuel ethanol by using agricultural and agroindustrial waste materials composed of lignocellulose, and especially sugar cane bagasse. These residues have significant contents of carbohydrates in the form of polysaccharides (cellulose and hemicellulose), which can be hydrolysed by chemical and enzymic processes.... Agent: Sughrue Mion, PLLC

20100035319 - Method for producing synfuel from biodegradable carbonaceous material: A bioreactor for producing synfuel from carbonaceous material includes a stacked particle heap comprising biodegradable carbonaceous material, an aerobic microbial consortium fermenting the biodegradable carbonaceous material into synfuel, and a gas impermeable barrier operatively covering the stacked particle heap. The covered particle heap is purged with at least one non-oxygenated... Agent: Dickstein Shapiro LLP

20100035320 - Methods and compositions for improving the production of products in microorganisms: Methods and compositions are provided for improving the production of products, such as fuel products like ethanol, in microorganisms. In particular, methods and compositions are described for improving ethanol production utilizing genes identified in Clostridium phytofermentans.... Agent: Fish & Richardson PC

20100035321 - Systems, devices, and, methods for releasing biomass cell components: Systems, devices, and methods for releasing one or more cell components from a photosynthetic organism. A bioreactor system is operable for growing photosynthetic organisms. Some of the methods include contacting the photosynthetic organism with an energy-activatable sensitizer, and activating the energy-activatable sensitizer, thereby releasing a cellular component from at least... Agent: Seed Intellectual Property Law Group PLLC

20100035322 - Non invasive method of electroporation mediated by carbon nanotubes and device for putting the method into practice: A non-invasive method for the electroporation of cells contained in a substrate wherein the cells are placed in contact with carbon nanotubes and then said substrate is subjected to the action of two orthogonal pulsed electric fields generated by means of two pairs of electrodes in contact with said substrate... Agent: Steinfl & Bruno

20100035323 - Methods of using a multiple sheath flow device for the production of microcapsules: The present invention provides methods for preparing microcapsules, each microcapsule comprising a semipermeable membrane, an aqueous core, one or more enzymes in the aqueous core, and one nucleic acid template in the aqueous core. Microcapsules are prepared by flowing (i) an innermost fluid flow comprising at least one enzyme and... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100035324 - Apparatus for the regeneration of human tissue: An apparatus for use in the regeneration of structured human tissue has a pair of opposed surfaces comprising a bio material or a synthetic polymer material. Each surface carries an active bio layer which can interact with stem cells from bone marrow. The opposed surfaces can be moved from an... Agent: Pauley Petersen & Erickson

20100035325 - Microcapsules and methods of use for amplification and sequencing: The present invention discloses thermostable microcapsules comprising a semipermeable membrane, an aqueous core, one or more enzymes in the aqueous core, and a nucleic acid template for an enzyme-mediated reaction in the aqueous core. In one embodiment of the invention, the aqueous core contains one or more polymerases. Microcapsules of... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100035326 - Nucleic acid terminators incorporating a cationic moiety and methods for their use: Disclosed are methods and kits applicable to sequencing methods, such as Sanger dideoxy sequencing methods. The methods and kits disclosed utilize a cationically charged nucleic acid terminator in combination with a discriminatory polymerase.... Agent: Life Technologies Corporation C/o Intellevate

20100035327 - Use of rice-derived products in a universal cell culture medium: s

20100035328 - Novel microorganism: The present invention provides a novel microorganism suitable for production of hydrogen. The microorganism according to the present invention is a Thermoanaerobacterium thermosaccharolyticum strain with an accession number of FERM BP-10793, or its mutants.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100035329 - Production of isoprenoids: The invention provides a biological method of producing isoprenoids.... Agent: Sheridan Ross PC

20100035330 - Bio-reactor: A bio-reactor for cultivating cells, comprising a culture vessel, at least one gas supply and/or liquid feed in addition to supply devices for gases and/or liquids enabling gases or liquids to be fed to the culture vessel. A mixture device, especially a Venturi nozzle is arranged between the supply device... Agent: Mayer & Williams PC

20100035331 - Method for extracting of nucleic acid from biological material: A method of extracting biological material-derived nucleic acid from samples containing biological material, the method comprising mixing biological material with an aqueous solution containing at least a surfactant, subjecting the mixture to heating treatment and then removing the aqueous solution to separate the biological material, adding a solid powder suspension... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100035334 - Biological sample measurement apparatus: A wireless blood glucose meter (2) is a battery (26)-powered apparatus to communicating wirelessly with a portable terminal (3), and includes a blood glucose level detector (21) that measures a blood glucose level, a transmitter (22) that transmits the blood glucose level measured by the blood glucose level detector (21)... Agent: Wenderoth, Lind & Ponack L.L.P.

20100035333 - Joined body to provide fluid analysis and manufacturing method thereof: A joined body to provide fluid analysis having an improved joining structure, and a manufacturing method thereof. The joined body includes a plurality of pieces, and adhesive passages formed inside the joined body and filled with an adhesive resin to form a joint, where the pieces are bonded to each... Agent: Stanzione & Kim, LLP

20100035335 - Metal-enhanced fluorescence for the label-free detection of interacting biomolecules: A method for enhancing fluorescence of a biomolecule includes the step of associating the biomolecule having intrinsic fluorescence with a sensing surface that contains nanostructured metal. Association of the biomolecule with the nanostructured metal enhances its intrinsic fluorescence, which is detected upon exposure to electromagnetic radiation of a suitable wavelength.... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20100035332 - Portable detection apparatus for beverage ingredients: Embodiments of the invention relate to portable detection apparatus, comprising one or more detector regions adapted to visually indicate the presence or amount of an analyte in a beverage. The detection apparatus is shaped substantially the same as a consumer product.... Agent: Schwegman, Lundberg & Woessner, P.A.

20100035336 - Cartridge retaining mechanism for nucleic acid extracting apparatus: A cartridge retaining mechanism equipped in a nucleic acid extracting apparatus for extracting a nucleic acid, the cartridge retaining mechanism comprising: a cartridge having a cylindrical shape with a bottom, and the bottom is shaped in a funnel shape; a nucleic acid-adsorbing solid carrier that traps a nucleic acid, and... Agent: Birch Stewart Kolasch & Birch

20100035337 - Bioreactor with window: Bioreactor having at least one transparent window (5, 12, 13), the inner side (6) of which can be touched by a medium that can be arranged in a reactor interior (3), wherein the window (5, 12, 13) has a photocatalytic coating (7) on its inner side (6) facing the reactor... Agent: Casella & Hespos

20100035338 - Holder for culture plates with de-nesting feature: A holding structure for holding a plurality of culture plates in a stacked arrangement includes a feature for de-nesting the bottom culture plate from the plate above it. The de-nesting feature is preferably a structure which urges a plate to move laterally relative to the plate above it. The de-nesting... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100035339 - Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor: The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member... Agent: Polsinelli Shughart PC

20100035340 - Variants of human taste receptor genes: Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur within the members of the T2R gene family. Some SNP's cause amino acid substitutions, while others introduce chain termination codons, rendering the allele... Agent: Klarquist Sparkman, LLP

20100035341 - Human embryonic stem cell-derived connective tissue progenitors for tissue engineering: Methods of generating and expanding proliferative, multipotent connective tissue progenitor cells from embryonic stem cells and embryoid bodies are provided. Also provided are methods of generating functional tendon grafts in vitro and bone, cartilage and connective tissues in vivo using the isolated cell preparation of connective tissue progenitor cells.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100035342 - Method for controlling ph, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield: Methods for controlling the level of dissolved carbon dioxide and limiting osmolality in a mammalian cell culture process to enhance cell growth, viability and density, and increase biologic product concentration and yield are provided. Such control of the level of dissolved carbon dioxide and pH as well as the resulting... Agent: Praxair, Inc. Law Department - M1 557

20100035343 - System and method for controlling a mammalian cell culture process: A system and method for controlling a mammalian cell culture process are provided. Such control of the cell culture process involves control of the level of dissolved carbon dioxide in the cell culture media and the resulting ability to prevent increases in the osmolality level is achieved by enhanced stripping... Agent: Praxair, Inc. Law Department - M1 557

20100035344 - Solutions for tissue engineering and methods of use: The present invention provides for solutions and methods of preparing a decellularized tissue for recellularization. The solutions provide collagen conditioning to restore collagen triple helix structure, strengthening of the collagen structure of the tissue, and biologically preparing the decellularized tissue by placing it in an environment that promotes recellularization. Methods... Agent: Polsinelli Shughart PC

20100035345 - High production system for infectious hepatitis c virus particle: The present invention relates to a method for producing infectious hepatitis C virus (HCV) particles, comprising a step of introducing an expression vector into a cell that allows HCV proliferation, such expression vector comprising: DNA sequences encoding the 5′ untranslated region, structural proteins, and, if necessary, non-structural proteins of HCV... Agent: Birch Stewart Kolasch & Birch

20100035347 - Method for increasing the survival of bacterial strains of the rhizobium genus: The present invention describes a method for increasing the survival of the bacteria of Rhizobium genus, comprising the steps of: making the bacteria to grow in a chemically defined medium; keeping the bacteria in growth stationary phase for a proper period of time; exposing the bacteria to effective quantities of... Agent: Juneau Partners

20100035346 - Single protein production in living cells facilitated by a messenger rna interferase: The present invention describes a single-protein production (SPP) system in living E. coli cells that exploits the unique properties of an mRNA interferase, for example, MazF, a bacterial toxin that is a single stranded RNA- and ACA-specific endoribonuclease, which efficiently and selectively degrades all cellular mRNAs in vivo, resulting in... Agent: Patent Docket Administrator Lowenstein Sandler PC

  
02/04/2010 > patent applications in patent subcategories. patent applications/inventions, industry category

20100028848 - Compositions and methods of using sirna to knockdown gene expression and to improve solid organ and cell transplantation: This invention describes compositions and methods using siRNA to target various genes expressed in cells of transplanted organs or tissues and/or genes expressed in the host to improve the success of the transplantation.... Agent: Ropes & Gray LLP

20100028849 - Novel process for devitalized/acellular tissue for transplantation: A method for processing tissue to produce a devitalized acellular matrix for transplantation comprises soaking the tissue in a first processing solution having a pH below 7 to reduce protease activity, periodically infusing ozone into the first processing solution to devitalize the tissue and reduce bioburden, and soaking the tissue... Agent: Kinney & Lange, P.A.

20100028850 - Perfusion regulation: A system and method for regulating cooperatively the pressures and flows of input vessels such as both the portal vein and hepatic artery for the liver. This invention solves problems of less-than-therapeutic portal vein flow during perfusion preservation by implementing cooperative regulation between the inputs, e.g., portal vein and hepatic... Agent: Oliff & Berridge, PLC

20100028851 - Multi-lineage progenitor cells: Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described.... Agent: Fish & Richardson P.C.

20100028852 - Methods and reagents for preserving rna in cell and tissue samples: This specification relates to the field of molecular biology and provides novel methods and reagents for preserving and protecting the ribonucleic acid (RNA) content of samples from degradation prior to RNA isolation. This preservation may be accomplished without ultra-low temperature storage or disruption of the tissue.... Agent: Life Technologies Corporation C/o Intellevate

20100028858 - high sensitivity assay for molecular typing of biological sample, probes and a kit thereof: The present invention relates to a high sensitivity assay for molecular typing of a biological sample using surface-enhanced Raman scattering (SERS) including resonance scattering (SERRS); capture probes for capturing nucleic acid; a detector probe to detect captured nucleic acid; a kit for molecular typing of biological sample using surface-enhanced Raman... Agent: Townsend And Townsend And Crew, LLP

20100028855 - Detection of influenza virus type b: The invention provides methods for detecting influenza B from its NS1 protein. The NS1 protein is present in detectable levels in clinical samples and can be detected using antibodies that are panspecific for influenza B without binding to influenza A or other viruses.... Agent: Townsend And Townsend And Crew, LLP

20100028859 - Hyper-spectral imaging and analysis of a sample of matter, and preparing a test solution or suspension therefrom: Method for hyper-spectral imaging and analysis of a sample of matter, for identifying and characterizing an object of interest therein. Preparing test solution or suspension of the sample, including adding thereto a spectral marker specific to object of interest, such that if object of interest is in test solution or... Agent: The Law Office Of Michael E. Kondoudis

20100028857 - Method for detecting and for removing endotoxin: The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins.... Agent: Fulbright & Jaworski L.L.P.

20100028856 - Method to detect virus related immunological markers for the diagnosis of hepatitis b virus infection: This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HBV-associated immunological markers in a serum sample for the diagnosis of HBV infection. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in... Agent: Weili Cheng

20100028854 - Methods for modeling infectious disease and chemosensitivity in cultured cells and tissues: The present invention provides methods for utilizing a form of optimized suspension culture to examine the infectivity of pathogenic organisms and agents in human cells and tissues. Also provided are methods using a rotating wall vessel to predict Chemosensitivity of cells and tissues to toxins and chemotherapeutic agents. These culture... Agent: Locke Lord Bissell & Liddell LLP Attn:IPDocketing

20100028853 - Optical determination of living vs. non living cells: A method of determining whether a cell sample in a medium contains living or dead cells of a predetermined target cell type is disclosed. The method includes preparing a testing substrate by attaching a binding molecule thereto, the binding molecule having the property of immobilizing cells of the target cell... Agent: Fellers Snider Blankenship Bailey & Tippens

20100028860 - Porcine reproductive and respiratory syndrome isolates and methods of use: A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined,... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100028897 - Apparatus and method for examining biopolymer: A biopolymer examining apparatus includes a capsule-forming unit configured to form a capsule by sealing a target biopolymer and a reagent with a capsule film, a transferring unit configured to transfer the capsule, an amplification reaction unit configured to amplify the target biopolymer while having the target biopolymer enclosed in... Agent: Canon U.s.a. Inc. Intellectual Property Division

20100028862 - Bacterial replication systems and methods: Reconstituted bacterial replication assemblies and methods for their use are provided.... Agent: Swanson & Bratschun, L.L.C.

20100028899 - Cell cycle phase markers: The present invention relates to polypeptide and nucleic acids constructs which are useful for determining the cell cycle status of a mammalian cell. Host cells transfected with these nucleic acid constructs can be used to determine the effects that test agents have upon the mammalian cell cycle.... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20100028889 - Companion diagnostic assays for cancer therapy: Methods for identifying cancer patients eligible to receive Bcl-2 family inhibitor therapy and for monitoring patient response to Bcl-2 family inhibitor therapy comprise assessment of the expression levels of the biomarker combinations set out in TABLES 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14,... Agent: Paul D. Yasger Abbott Laboratories

20100028890 - Compositions, methods, and kits for analyzing dna methylation: Compositions, methods, and kits for reducing strand amplification bias using bisulfite treated gDNA are provided. Methods for detecting and for quantitating the amplified bisulfite treated gDNA and inferring the presence, absence, and/or degree of methylation of target cytosine(s) in the gDNA are also provided. Such methods typically employ tailed first... Agent: Life Technologies Corporation C/o Intellevate

20100028870 - Design of synthetic nucleic acids for expression of encoded proteins: Methods for determining a property that affects expression of polynucleotides are provided. A plurality of polynucleotides each encoding a polypeptide sequence is constructed. A frequency that a sequence element is used in a first polynucleotide is different than in a second polynucleotide. Each polynucleotide is expressed in an expression system... Agent: Jones Day

20100028884 - Detection of penicillin tolerance in group b streptococcus: single nucleotide polymorphisms in penicillin binding protein 4: Disclosed are methods of detecting penicillin tolerance in Group B Streptococcus by detecting at least one of two single nucleotide polymorphisms (SNP) in penicillin binding protein 4. Also disclosed are primers and hybridization probes that may be used in such methods.... Agent: Medical Diagnostic Laboratories, LLC

20100028876 - Diagnostic tests using gene expression ratios: The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from cell or tissue samples, such as cancer cell or tissue samples. The invention also provides sets of genes that are expressed differentially in normal and cancer lung cells and tissues. These sets... Agent: Wolf Greenfield & Sacks, P.C.

20100028866 - Dopaminergic neuron proliferative progenitor cell marker nato3: The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can... Agent: Townsend And Townsend And Crew, LLP

20100028881 - Extracellular and membrane-associated prostate cancer markers: This document relates to methods and materials involved in identifying, assessing, and monitoring prostate cancer in male mammals. For example, this document provides arrays for detecting polypeptides or nucleic acids that can be used to identify prostate cancer in male mammals. In addition, methods and materials for assessing and monitoring... Agent: Fish & Richardson P.C.

20100028874 - Hepatitis c virus infection biomarkers: A signature set of genes associated with hepatitis C virus infection is described.... Agent: Vertex Pharmaceuticals Inc.

20100028863 - High throughput assay for cancer cell growth inhibition: A high-throughput, anchorage-independent assay is described, which screens compounds for inhibition of cancer cell growth. The assay utilizes a three-dimensional matrix or semi-solid media transfected with the subject compound, and enables live colony growth determination and imaging.... Agent: Eckert Seamans Cherin & Mellott

20100028885 - Labelled nucleotides: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.... Agent: Klauber & Jackson

20100028871 - Light-inducible and rhythmically expressed genes and method for screening substances that affect an internal clock system: A method for screening a substance that affect an internal clock system in an organism, comprising the detection of the expression level of a gene exhibiting a light-inducible and rhythmic expression in a circadian manner, which is typically expressed in the suprachiasmatic nucleus of mammalian, such as for example, Dusp4,... Agent: Morris Manning Martin LLP

20100028867 - Lrrtm1 compositions and methods of their use for the diagnosis and treatment of cancer: Microarray analysis, confirmed by RT-PCR, demonstrated that mRNA from certain cancer tissues, for example, ovarian cancer tissue, pancreatic cancer tissue, and colorectal cancer tissue, hybridizes specifically and preferentially to LRRTM1. LRRTM1 is a leucine-rich repeat transmembrane protein overexpressed on the surface of cancer cells compared to normal tissues and thus... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100028891 - Method for determining the sensitivity or resistance of retrovirus isolates to molecules, therapeutic retroviral treatments based on viral protease inhibitors and diagnostic kits: A method of determining sensitivity or resistance of isolates of HIV retroviruses to a molecule includes a) amplifying sequences coding for a protease of a retrovirus to be studied, with or without the or some of amino acid sequences situated upstream and downstream of a cleavage site of a precursor... Agent: Ip Group Of Dla Piper LLP (us)

20100028895 - Method for determining the stability of organic methyleneamines in the presence of semicarbazide-sensitive amine oxidase: The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing an methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100028875 - Method for diagnosing cancer by detecting the methylation of transitional zones: The present invention relates to a method for diagnosing cancer and predicting metastasis or prognosis by measuring the methylation of transitional zones and a primer for detecting the methylation. According to the present invention, a novel transitional zone is understood and a primer for detecting the methylation of the zone... Agent: North Star Intellectual Property Law, PC

20100028883 - Method for evaluation of tissue preservation solution: The present invention provides a method for evaluating preservative effect of a tissue preservation solution, comprising immersing a mammalian tissue introduced with a luminescence or fluorescence labeling gene in the tissue preservation solution, measuring a luminescence or fluorescence level by the labeling gene in the tissue after immersion, and evaluating... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100028865 - Method for identifying regulatory t cells: The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer, cancer treatment and/or organ transplantation based on regulatory T cell quantity, to methods and kits... Agent: Mcdermott Will & Emery LLP

20100028880 - Method for sustained expression of an exogenous gene: A method for sustained expression of an exogenous gene forms a circular episomal plasmid to solve the problem of transient expression of baculovirus in the transduced mammalian cells caused by the dilution and degradation when mammalian cells replicate and also prevents dysfunctional cell metabolism.... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20100028898 - Method of identifying a target analyte using photonic crystal resonators, and related device: the identification of at least one target analyte is carried out through the analysis of the total emission spectrum coming from said plurality of photonic crystals resonators, in order to detect possible wavelength resonance peaks generated as a result of the binding of said target analyte, bound to the common... Agent: Sughrue Mion, PLLC

20100028869 - Method to assess susceptibility to androgenic alopecia: The present invention relates to a method to assess the susceptibility to androgenetic alopecia comprising detecting the presence of polymorphisms in the EDA2R gene.... Agent: Kenneth K. Sharples Law Office Of Kenneth K. Sharples

20100028887 - Method, kit and system for collecting and processing samples for dna and rna detection: This invention relates to a method, kit and system for collecting and processing of samples to release and treat DNA and RNA for gene sequence detection. The method described here in provides for rapid and convenient release, and recovery of DNA and RNA from tissues and cellular materials.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100028893 - Methods and compositions for pharmacogenetic analysis of anti-inflammatory drugs in the treatment of rheumatoid arthritis and other inflammatory diseases: The invention provides methods and compositions for the pharmacogenetic analysis of anti-inflammatory compounds, especially for the pharmacogenetic association of responsiveness to rheumatoid arthritis medications that target TNFα.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20100028873 - Methods and means for nucleic acid sequencing: The present invention provides a nucleic acid sequencing method. The method comprises enriching a nucleic acid sample for target nucleic acids, where the nucleic acid sample is enriched through at least a first round of hybridization selection and amplification, and a second round of hybridization selection and amplification. The enriched... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100028882 - Methods for diagnosing osteoarthritis: Methods are disclosed for assessing risk of developing osteoarthritis. Said methods comprise determining the cellular localizations, blood or synovial fluid concentrations, sumoylation states and post-translational modifications of pituitary homeobox transcription factor 1 (pitx-1) repressor proteins, identifying mutations in genes which encode said proteins and identifying any mutations or post-translational modifications... Agent: Goudreau Gage Dubuc

20100028888 - Methods for producing a paired tag from a nucleic acid sequence and methods of use thereof: Methods for producing a paired tag from a nucleic acid sequence are provided in which the paired tag comprises the 5′ end tag and 3′ end tag of the nucleic acid sequence. In one embodiment, the nucleic acid sequence comprises two restriction endonuclease recognition sites specific for a restriction endonuclease... Agent: Life Technologies Corporation C/o Intellevate

20100028872 - Methods for the detection of cancer: Methods, compositions, and kits for the detection of cancer, particularly renal cancer, are provided.... Agent: Dann, Dorfman, Herrell & Skillman

20100028886 - Methods of determining properties of molecules: This disclosure features, inter alia, methods for determining at least one property of a nucleic acid. The methods include: (a) fixing the nucleic acid on a planar surface; (b) digesting the nucleic acid into fragments with at least one enzyme; (c) imaging the nucleic acid; and (d) analyzing the imaged... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20100028879 - Modulators of hsd17b7 for treating acne or hyperseborrhea: An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of hydroxysteroid (17-beta) dehydrogenase type 7, and the use of modulators of the expression or activity of this... Agent: Buchanan, Ingersoll & Rooney PC

20100028878 - Modulators of udp-glucose ceramide glucosyltransferase for treating acne or hyperkeratinization: An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of UDP-glucose ceramide glucosyltransferase (UGCG), and the use of modulators of the expression or activity of this enzyme... Agent: Buchanan, Ingersoll & Rooney PC

20100028877 - Molecule for providing a standard for the quantitative analysis of the methylations status of a nucleic acid: The invention refers to a nucleic acid for providing a standard in the quantitative bisulfite based analysis of the methylation status of a DNA molecule with a given sequence, wherein the given sequence comprises at least one CpG position that is to be analyzed for its methylation status. This nucleic... Agent: Kriegsman & Kriegsman

20100028894 - Photographic determination of analytes: The present invention refers to a detection method for analytes using the principle of black-and-white photography and to reagent kits for performing the method, furthermore applied this new technology to detect a biologically relevant sequence in the nanomolar range (femtomoles) in an application circumventing the necessity of a PCR. There... Agent: Brinks, Hofer, Gilson & Lione

20100028861 - Probe set and method for identifying hla allele: Provided is a probe set that is useful for identifying each allele of HLA individually, and a method of identification of an allele of HLA by the use thereof for each type. The probe set is composed of probes that cover all of the partial sequences that contain a unique... Agent: Fitzpatrick Cella Harper & Scinto

20100028864 - Reagents and methods for detecting neisseria gonorrhoeae: This invention provides compositions and methods for detecting Neisseria gonorrhoeae in a sample. This invention also provides related reaction mixtures, kits, systems, and computers.... Agent: Roche Molecular Systems, Inc. Patent Law Department

20100028868 - Responsiveness to therapy for liver disorders: Sets of nucleic acids and methods for predicting a subject's responsiveness to therapy for liver disorders.... Agent: Fish & Richardson PC

20100028896 - Rotary extraction container and method of identifying cell species, method of detecting gene, and automatic nucleic acid extractor using the same: Disclosed is a rotary extraction container enabling to safely and simply perform extraction and separation of a target substance from a sample containing plural substances. Specifically, there is disclosed a rotary extraction container enabling to simply perform extraction and separation of a nucleic acid from a biological sample or from... Agent: Cantor Colburn, LLP

20100028900 - Screening methods and sequences relating thereto: Disclosed are screening methods and sequences related thereto. Disclosed are methods for detecting mutations in the MYH gene of an individual. Also disclosed are methods of genotyping and methods of predicting for an individual the likelihood of developing certain cancers, such as colorectal cancer.... Agent: Myriad Genetics Inc. Intellectual Property Department

20100028892 - Yeast based expression of proteases and methods of use: This disclosure generally relates to components and methods of using a high throughput screening (HTS) systems for intracellular proteases, using Caspases as a prototype. Genetic systems are disclosed for monitoring exogenous caspase activation pathways in the yeast, Saccharomyces cerevisiae. The yeast-based cellular systems permit facile expression of proteases (e.g., caspase)... Agent: Dla Piper LLP (us)

20100028905 - Characterization of grp94-ligand interactions and purification, screening, and therapeutic methods relating thereto: The presently disclosed subject matter discloses characterization of interactions between ligands and Hsp90 proteins, including GRP94, wherein ligand binding to the N-terminal nucleotide binding domain of GRP94 elicits a conformational change that converts the GRP94 from an inactive to an active conformation, and wherein the chaperone and peptide-binding activities of... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20100028902 - Living cell force sensors and methods of using same: Disclosed herein are materials and methods for the efficient and universal fabrication of microcantilevers terminated with living cells. Methods disclosed describe the passive attachment of cells to microcantilevers that represent cells in suspension comprising living cells attached thereto via association with a hydrophobic layer. Also, disclosed are efficient methods for... Agent: Beusse Wolter Sanks Mora & Marie

20100028903 - Method and device for examining the attachment or detachment of living or dead cells or cell-like particles or other surface accumulations on surfaces by means of plasmon resonance and use of said method and said device: The invention relates to the examination of the attachment or detachment of living or dead cells, or cell-like particles, or other surface accumulations on surfaces, by means of plasmon resonance. The reflected light is evaluated such that two or more intensity minima of the reflected light occurring within a time... Agent: Michael J. Striker

20100028901 - Method for diagnosing in vitro or ex vivo psychiatric disorders and/or intestinal dysbioses: e

20100028906 - Reducing the risk of human anti-human antibodies through v gene manipulation: The present embodiments relate to methods of identifying and creating human or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for... Agent: Knobbe Martens Olson & Bear LLP

20100028904 - Way to obtain high expression clones of mammalian cells using a methylcellulose with fluorescent protein a or g and fluorescent screening method: The invention provides a genetic screening method for identifying a transfected cell expressing the polypeptide of interest. The methods allows for high throughput screening of recombinant cells for elevated levels of expression of the polypeptide of interest using methylcellulose comprising fluorescent protein A or G to improve detection and cloning.... Agent: Philip S. Johnson Johnson & Johnson

20100028910 - Activated protein c variants with normal cytoprotective activity but reduced anticoagulant activity: Variants (mutants) of recombinant activated protein C (APC) or recombinant protein C (prodrug, capable of being converted to APC) that have substantial reductions in anticoagulant activity but that retain normal levels of anti-apoptotic activity are provided. Two examples of such recombinant APC mutants are KKK191-193AAA-APC and RR229/230AA-APC. APC variants and... Agent: Loeb & Loeb LLP

20100028912 - Imaging using radioactive monocations in combination with a receptor binding ligand that stimulates the influx of cations: A novel method of imaging, comprising administration of a radioactive mono-cation, such as, for example, 82Rubidium (positron imaging) or Thallium (SPECT or planar imaging), in combination with a receptor binding ligand that stimulates the influx of cations. The method permits imaging of receptor-expressing tissue. However, unlike imaging methods which rely... Agent: Bracco Research Usa Inc.

20100028911 - Multicolor reagents containing compensation controls: The present invention provides multicolor reagent formulations containing in a single container both fluorescently labeled detection reagents and single-color compensation control reagents, wherein the compensation control reagents consist of reagent-capture particles bound to a fluorescently labeled detection reagent included in the multicolor reagent formulation. The multicolor reagent formulations of the... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100028913 - Novel carbohydrate from human cells and methods for analysis and modification thereof: The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins... Agent: Birch Stewart Kolasch & Birch

20100028914 - Assessing lung nodules: This document provides methods and materials related to distinguishing malignant solitary pulmonary nodules from benign solitary pulmonary nodules in mammals (e.g., humans).... Agent: Fish & Richardson P.C.

20100028915 - Circulating tumor cell assay: Methods for the detection, enumeration and analysis of circulating tumor cells expressing insulin-like growth factor-1 receptors (IGF-1R) are disclosed. These methods are useful for cancer screening and staging, development of treatment regimens, and for monitoring for treatment responses, cancer recurrence or the like. Test kits that facilitate the detection, enumeration... Agent: Pfizer Inc

20100028907 - Novel antigens and antibodies associated to pancreatic ductal adenocarcinoma: The present invention provides novel human protein antigens and related antibodies that have been identified as being specifically expressed in association to human Pancreatic Ductal Adenocarcinoma (PDA). In particular, novel phosphorylated isoforms of alpha-enolase have been identified in transformed cell lines of pancreatic origin and antibodies binding such isoforms are... Agent: Marshall, Gerstein & Borun LLP

20100028908 - Novel detection system: The present invention relates to methods of making nanoarrays for use in detecting species formed on the surface of the array using SE(R)RS. The methods can involve nanolithographic printing of a compound by dip pen nanolithographic printing. A SE(R)RS substrate can be used for the array and which can be... Agent: Alston & Bird LLP

20100028916 - Method for the detection of enzymatic reactions: The present invention provides a method for the detection of an enzyme E1 in a liquid sample comprising the steps of: a) providing a complex (Sa-Sb-M), wherein (Sa-Sb) is a substrate S of E1 cleavable into Sa and Sb by E1, and M is a marker linked to Sb, b)... Agent: Clark & Elbing LLP

20100028909 - In vitro method for diagnosing and monitoring metastasized bladder cancer using the determination of mmp-7 in the circulation of patients: The present invention relates to the use in diagnostic in vitro methods for the detection, early detection, monitoring and/or prognosis of metastatic bladder cancer in human patients of matrix metalloproteinase 7 (MMP-7) and/or its precursors and fragments with MMP-7 immunoreactivity that can be measured in blood, serum or plasma samples... Agent: Heslin Rothenberg Farley & Mesiti PC

20100028917 - A neuroglobin enzyme-linked immunosorbent assay kit and the use of it: The invention discloses a Neuroglobin enzyme-linked immunosorbent assay kit and the use of it. The Neuroglobin enzyme-linked immunosorbent assay kit provided by the invention includes Neuroglobin polyclonal antibody, Neuroglobin monoclonal antibody and enzyme labeled antibody. Neuroglobin monoclonal antibody is produced through culturing hybridoma cells prepared by cell conjugation after inoculating... Agent: Turocy & Watson, LLP

20100028918 - Glutaminyl cyclase as a diagnostic/prognostic indicator for neurodegenerative diseases: A method for predicting, diagnosing and prognosticating a neurodegenerative disease, such as Alzheimer's disease (AD), Mild Cognitive Impairment (MCI) and neurodegeneration in Down's syndrome (NDS) using glutaminyl cyclase (QC) as a diagnostic/prognostic indicator. The use of antibodies binding to QC and kits for performing said diagnostic method are also provided.... Agent: Sonnenschein Nath & Rosenthal LLP

20100028919 - Method for the early detection of renal injury: A method and kit for detecting the immediate or early onset of renal disease and injury, including renal tubular cell injury, utilizing NGAL as an immediate or early on-set biomarker in a sample of blood serum. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected... Agent: Hasse & Nesbitt LLC

20100028920 - Hydrogen peroxide droplet-based assays: The present invention relates to providing improved hydrogen peroxide assays, as well as droplet actuators for conducting such assays. The droplet actuators of the invention may be used to conduct droplet-based hydrogen peroxide assays. They may also be associated with detectors for analyzing the results of the hydrogen peroxide assays... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.

20100028922 - Identification and characterization of hcv replicon variants with reduced susceptibility to benzofurans, and methods related thereto: The present invention provides methods of decreasing the frequency of emergence, decreasing the level of resistance, and delaying the emergence of a treatment-resistant Hepatitis C viral infection, by administering to a subject, either in combination or in series, an inhibitor of the Hepatitis C RNA-dependent RNA polymerase NS5B, e.g., a... Agent: Fitzpatrick Cella Harper & Scinto

20100028921 - Risk stratification for acute coronary syndrome by means of fragments/partial peptides of provasopressin, especially copeptin or neurophysin ii: The invention relates to a method for risk stratification for acute coronary syndrome (ACS), in particular acute myocardial infarction (AMI) and angina pectoris (AP), wherein provasopressin (proAVP) or fragments and partial peptides thereof, in particular copeptin or neurophysin II, is determined by an in vitro diagnosis.... Agent: Connolly Bove Lodge & Hutz, LLP

20100028923 - Cross-reactive sensors: The present invention provides a novel cross-reactive sensor system utilizing cross-reactive recognition elements. In the inventive system, each of said one or more cross-reactive recognition elements is capable of interacting with more than one species of liquid analyte of interest, whereby each of said one or more cross-reactive recognition elements... Agent: Choate, Hall & Stewart LLP

20100028924 - Method of diagnosing pon1-hdl associated lipid disorders: Methods and kits for diagnosing a lipid-related disorder are disclosed. Methods and pharmaceutical compositions for treating lipid-related disorders are also disclosed.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100028925 - Method and device for the analysis of enzyme activity in fluids: An assay in which alkaline phosphatase is detected on one of a number of membranes held on a holder. A liquid sample and a substrate are combined on the membrane. If the enzyme is present, the substrate is cleaved. The products of this cleavage are optically detectable.... Agent: Schneck & Schneck

20100028926 - Novel enzymatic substrates derived from phenoxazinone and their use as developer in detection of microorganisms with peptidase activity:

20100028927 - Seafood spoilage indicator: An enzyme based nondestructive sensor for the qualitative detection of spoilage in seafood is provided wherein the sensor does not alter the physical composition of the seafood specimen. The sensor comprises a sampling matrix, at least three or more enzymes in contact with the sampling matrix, and at least one... Agent: Buchanan Ingersoll & Rooney PC

20100028935 - Convex bottom microwell: Convex-bottom microwells for laboratory use in optical analyses of colorimetric or enzymological type useful for avoiding interferences with the luminous beam of the detecting instrument by corpuscular elements present in the sample to be analysed.... Agent: Nixon & Vanderhye, PC

20100028936 - Detection of cancer cells in vitro using sigma-2 receptor ligands as radiotracers: wherein at least one of X, Y, and Z comprises a radioisotope, n is an integer from 2 to about 10; and each of A and A1 is a C1-C4 alkoxyl, a C1-C4 fluoroalkyl or a C1-C4 fluoroalkoxyl. The methods further comprise detecting the distribution of the radioisotope in the... Agent: Washington University-snr C/o Sonnenschein Nath & Rosenthal L.l.p

20100028928 - Device for high-throughput stimulation, immunostaining, and visualizaion of single cells: Cell stimulation, staining, and visualization are common techniques in both clinical and research settings. The invention is directed to microfluidic devices for in situ cell stimulation, staining, and/or visualization, and related methods for applying one or more stimuli to the cells, and fixing and staining of cells in situ. The... Agent: Edwards Angell Palmer & Dodge LLP

20100028932 - General prognostic parameters for tumour patients: Described is a method for identifying the prognosis for improved clinical benefit of an individual suffering from a tumor comprising providing a blood sample of said individual, (a1) determining the number of lymphocytes in the blood of said individual, and/or (a2) determining the number of neutrophils in the blood of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100028930 - Hematopoietic cell phenotyping using circulating cell-free markers: The present invention provides methods of classifying cluster of differentiation (CD) marker phenotype for hematopoietic cancer cells using multiple circulating cell-free CD markers in bodily fluid. In other aspects, treatment and disease progression of particular hematopoietic cancers can be monitored by measuring the levels of CD and other markers i... Agent: Foley & Lardner LLP

20100028931 - Neurodegenerative diseases and methods of modeling: Disclosed are embryonic stem cells and motor neurons derived from mice carrying transgenic alleles of the normal or mutant human SOD1 gene. Also disclosed are in vitro systems employing such SOD1 transgenic motor neurons for the study of neural degenerative disease.... Agent: David S. Resnick

20100028929 - Nucleic acid molecules encoding gpr84: The present invention is an isolated nucleic acid molecule encoding CD36, Gqi9, and G protein-coupled receptor 84 (GPR84) proteins as well as vectors and recombinant host cells which co-express CD36, Gqi9, and GPR84 proteins for use in identifying modulators of GPR84 activity.... Agent: Licata & Tyrrell P.C.

20100028933 - Nutrient medium unit and method for holding a filter from a filtration device: The invention relates to a nutrient medium unit for holding a filter of a filtration device, comprising a lower part that is filled with the nutrient medium and a lid, the latter having a fixing edge that protrudes into the lower part and that can be connected to an edge... Agent: Casella & Hespos

20100028934 - Pipette tip and a method for pipetting a congealed blood sample utilizing the pipette tip: A pipette tip and a method for pipetting a congealed blood sample utilizing the pipette tip are disclosed. The pipette tip includes an attachment section configured to be attached to a dispensing device, a liquid containing section configured to receive at least part of an aspired liquid sample, and a... Agent: Dinsmore & Shohl, LLP Fifth Third Center

20100028937 - Test strip for detecting gastric problems and detecting method thereof: The present invention provides a test strip and a detecting method thereof. The test strip comprises a first sheet, a second sheet a first filter and a second filter. The first sheet comprises a bulge portion deposited substantially in the center thereof. The second sheet comprises a depression in alignment... Agent: Sinorica, LLC

20100028938 - Method of screeing for pathogens: e

20100028939 - Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest: This invention relates to novel compounds, methods for selective chemical conjugation of protractor molecules and the use thereof for diagnostic and/or therapeutic purposes.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20100028940 - Compositions and methods for metabolic selection of transfected cells: The present invention relates to novel selection marker vectors, and methods for using these vectors to generate stable gene expression systems in eukaryotic cells utilizing any enzyme useful in the eukaryotic sterol/cholesterol biosynthetic pathway, such as a 3-ketosteroid reductase, as a metabolic selection marker to select transfected cells. In one... Agent: Womble Carlyle Sandridge & Rice, PLLC

20100028945 - Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor: Stress-related nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, stress-related fusion proteins, antigenic peptides, and anti-stress-related antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and host cells into which the... Agent: Alston & Bird LLP

20100028941 - Method for multiparallel construction of host/vector-systems for expression of proteins: The present invention relates to a multiparallel method for construction of host/vector-systems, comprising transforming a plurality of host strains, wherein substantially all host strains have deleterious mutations in at least one uptake system for a critical substrate needed for the growth of said host strain, with a plurality of vectors... Agent: Porter Wright Morris & Arthur, LLP Intellectual Property Group

20100028942 - Methods for improving viability and productivity in cell culture: Methods for increasing viability and production of secreted proteins in fed batch eukaryotic cell culture are disclosed.... Agent: Philip S. Johnson Johnson & Johnson

20100028944 - Methods of obtaining genetic competence in bacillus cells: The present invention relates to methods of obtaining genetic competence in non-competent Bacillus cells for their transformation with exogenous DNA.... Agent: Novozymes, Inc.

20100028943 - Modified messenger rna stabilizing sequences for expressing genes in bacterial cells: The present invention relates to methods of producing a polypeptide having biological activity in a bacterial cell, comprising: (a) cultivating a bacterial host cell in a medium conducive for production of the polypeptide, wherein the bacterial host cell comprises a nucleic acid construct comprising a promoter region operably linked to... Agent: Novozymes, Inc.

20100028951 - Production of glycoproteins with modified fucosylation: Methods are disclosed for genetically engineering host cells that lack an endogenous pathway for fucosylating N-glycans of glycoproteins to be able to produce glycoproteins with fucosylated N-glycans.... Agent: Merck And Co., Inc

20100028946 - Fusion partner cells: Fusion partner cells that enable production of heterohybridomas even from cells of species other than mouse were produced by fusing myeloma cells derived from a first animal species with leukemia cells derived from a second animal species, which have an extra S phase in the cell cycle and have the... Agent: Bozicevic, Field & Francis LLP

20100028948 - Methods of administering/dosing anti-rsv antibodies for prophylaxis and treatment: The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of... Agent: Jones Day

20100028949 - Shrna-mediated inhibition of expression of alpha 1,6-fucosyltransferase: The current invention comprises a method for producing a heterologous polypeptide with a reduced degree of fucose modification in a mammalian cell by cultivating the mammalian cell under conditions suitable for the expression of said heterologous polypeptide, and recovering the heterologous polypeptide from the mammalian cell or the culture, wherein... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100028947 - Use of human cells of myeloid leukaemia origin for expression of antibodies: The invention relates to a method for producing a protein molecule composition having a defined glycosylation pattern, comprising (a) introducing in a host cell which is an immortalized human blood cell at least one nucleic acid encoding at least a part of said protein; and (b) culturing said host cell... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100028950 - Method for the immobilization of biologically active polypeptides by using maltose binding protein: The present invention relates to a method for immobilization of a biologically active polypeptide using maltose binding protein (MBP) and a biologically active solid substrate on which a biologically active polypeptide is immobilized by the above method. More particularly, the present invention relates to a method for immobilization of a... Agent: Greenlee Winner And Sullivan P C

20100028952 - Fermentation and purification of actinomadura chromoprotein and related species: The present invention provides methods for production and purification of active chromoproteins produced by Actinomadura sp. 21G792. The chromoproteins are useful for developing pharmaceutical compositions and treating diseases such as cancer or bacterial infections.... Agent: Wyeth LLC Patent Law Group

20100028953 - Methods for production of oligonucleotides: The present invention relates to production of oligonucleotides using rolling circle replication, wherein synthesised multimeric oligonucleotides are reduced to mononucleotides using a nicking cassette. Thus, the invention provides a method for the production of oligonucleotides, enabling efficient amplification of oligonucleotides at lengths up to at least 1000 nucleotides and in... Agent: Sunstein Kann Murphy & Timbers LLP

20100028955 - Sequence amplification with target primers: The present disclosure relates to the amplification of target nucleic acid sequences for various sequencing and/or identification techniques. This can be accomplished via the use of target primers and isothermal multiple strand displacement (MDA) processes. The use of these target primers and MDA, as described herein, allows for, for example,... Agent: Life Technologies Corporation C/o Intellevate

20100028954 - Template-dependent nucleic acid polymerization using oligonucleotide triphosphate building blocks: A novel use of a template-dependent polymerase. The novel use is effected by employing the template-dependent polymerase for incorporating at least one oligonucleotide triphosphate onto a nascent oligonucleotide-3′-OH in a template-dependent manner.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20100028956 - Genetically engineered recombinant escherichia coli producing l-tryptophan having originally l-phenylalanine productivity, and method for producing l-tryptophan using the microorganism: The present invention relates to a microorganism having L-tryptophan productivity and a method for producing L-tryptophan using the same. More precisely, the present invention relates to the recombinant E. coli strain CJ600 (KCCM 10812P) having tryptophan productivity produced from the mutant form (KFCC 10066) of E. coli having L-phenylalanine productivity,... Agent: Swanson & Bratschun, L.L.C.

20100028958 - Method for production of l-amino acid: A method for producing an L-amino acid is described, which is characterized by culturing a Vibrio bacterium capable of producing the L-amino acid in a culture medium to produce and accumulate the L-amino acid in the culture medium and collecting the L-amino acid from the culture medium.... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20100028957 - Microorganism of corynebacterium genus having enhanced l-lysine productivity and a method of producing l-lysine using the same: The present invention relates to a microorganism of Corynebacterium genus having enhanced L-lysine productivity and a method of producing L-lysine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus having enhanced L-lysine productivity by inactivating endogenous NCgI 1090 gene having the amino acid... Agent: Swanson & Bratschun, L.L.C.

20100028959 - Method for production of l-amino acid: The present invention has its object to provide a method for producing an L-amino acid comprising reacting a keto acid with an amino acid dehydrogenase and an enzyme having coenzyme regenerating ability to convert to a L-amino acid, wherein a coenzyme is added in two or more portions in the... Agent: Connolly Bove Lodge & Hutz LLP

20100028960 - Preparation of precisely controlled thin film nanocomposite of carbon nanotubes and biomaterials: Disclosed are nanocomposite materials comprising multiple layers of biomolecules bound to aligned carbon nanotubes. The thickness of each of the layers may be precisely controlled using a layer-by-layer assembly technique.... Agent: Andrus, Sceales, Starke & Sawall, LLP

20100028962 - Algal medium chain length fatty acids and hydrocarbons: The present invention provides methods and compositions for production of algal-based medium chain fatty acids and hydrocarbons.... Agent: Mcandrews Held & Malloy, Ltd

20100028961 - Biogical production of fuels: A process for the production of one or more fatty acids or derivatives thereof from a carbohydrate, which process comprises treating of Jerusalem Artichoke the carbohydrate with a micro-organism which converts the carbohydrate to a microbial oil comprising one or more fatty acids or derivatives thereof, in which the carbohydrate... Agent: Nixon & Vanderhye, PC

20100028963 - System for producing aromatic molecules by bioconversion: Yeast comprising at least one gene encoding vanillyl alcohol oxidase, the sequence of which is the sequence SEQ ID No. 1 or any sequence at least 70%, preferably 80%, very preferably 90% homologous to the sequence SEQ ID No. 1, and methods for producing coniferyl alcohol, ferulic acid and vanillin.... Agent: Young & Thompson

20100028964 - Method for production of microbial fermentation product: a

20100028965 - Method for producing 1,3-propanediol using crude glycerol, a by-product from biodiesel production: The invention discloses a method for producing 1,3-propanediol, comprising the steps of: using crude glycerol, a by-product during the biodiesel production, without further treatment, as the substrate for production of 1,3-propanediol; inoculating a 1,3-propanediol-producing strain in a seed medium containing crude glycerol, a by-product from biodiesel production; adding the seed... Agent: Millen, White, Zelano & Branigan, P.C.

20100028966 - Methods and compositions for improving the production of products in microorganisms: Methods and compositions are provided for improving the production of products, such as fuel products like ethanol, in microorganisms. In particular, methods and compositions are described for improving ethanol production utilizing genes identified in Clostridium phytofermentans.... Agent: Fish & Richardson PC

20100028968 - Biomechanical treatment for obesity and diabetes: Methods of maintaining or improving the metabolic state of a subject, e.g., a human, are disclosed. The methods can include providing to the subject a low magnitude, high frequency mechanical signal on a periodic basis and for a time sufficient to maintain or improve the subject's metabolic state. The subject... Agent: Fish & Richardson PC

20100028967 - Method of changing property or function of substance and method of eliminating biofunction of cell: There are provided a method of changing a property or function of a substance by fragmenting a protein contained in the substance floating in a gas, and a method of eliminating a biofunction of a cell by applying to the cell either an electric discharge or a particle produced by... Agent: Birch Stewart Kolasch & Birch

20100028969 - Cell lysis or electroporation device comprising at least one pyroelectric material: The present invention relates to a cell lysis or electroporation device comprising at least one pyroelectric material.... Agent: Philips Intellectual Property & Standards

20100028970 - Medium for the production of tiacumicin b: Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species Dactylosporangium aurantiacum subspecies hamdenensis having the ability to produce and accumulate one or more Tiacumicin in a nutrient medium comprising a carbon source, a nitrogen source, trace elements such as... Agent: Cohen, Pontani, Lieberman & Pavane LLP

20100028971 - Carriers for enzyme or cell immobilization and immobilization method using the carriers: The invention discloses a carrier made from an organic foam having open pores for enzymes or cells immobilization and the methods for preparing immobilized enzymes or cells. The invention uses flocculation and crosslinking technology to immobilize enzyme protein or cells on the organic foam material having open pores. The resultant... Agent: The Webb Law Firm, P.C.

20100028972 - Ketoreductase polypeptides and related polynucleotides: The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host... Agent: Dechert, LLP

20100028973 - Method for proliferating hepatitis virus, hollow fiber for culturing hepatitis virus-infected cells, and use thereof: The present invention provides (i) a method for proliferating a hepatitis virus, the method including the steps of: infecting, with the hepatitis virus, cells packed into a lumen of a hollow fiber made of a permeabilized membrane; and culturing the cells or (ii) a method for proliferating a hepatitis virus,... Agent: Leydig Voit & Mayer, Ltd

20100028974 - Novel bacillus bacterium strain capable of decomposing/volume-reducing plant residue: Disclosed is a method for decomposing a plant residue and reducing a volume of the plant residue to a satisfactory level within a short period. Also disclosed is a bacterium for use in the method. Further disclosed is a material for decomposing a plant residue and reducing a volume of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100028975 - Traits in recombinant xylose-growing saccharomyces cerevisiae strains using genome-wide transcription analysis: New xylose-utilizing Saccharomyces cerevisiae strain which can ferment xylose to ethanol. It expresses the gene for A) xylose reducatse (XR) and Xylitol dehydrogenase (XDH) or B) xylose isomerase (XI) and has a) increased transporting capacity with regard to xylose, b) increased conversion capacity of xylulose to xylulose-5P, c) increased activity... Agent: Gauthier & Connors, LLP

20100028977 - Enclosed photobioreactors with adaptive internal illumination for the cultivation of algae: The present invention provides an enclosed, internally-lighted bioreactor apparatus, methods for growing photosynthetic microorganisms in the enclosed, internally lighted bioreactor and methods for enhancing growth of a photosynthetic microorganism culture in the enclosed internally-lighted bioreactor.... Agent: Brinks Hofer Gilson & Lione

20100028976 - Photobioreactor and uses therefor: The present invention provides novel photobioreactors, modules thereof, and methods for use in culturing and harvesting algae and cyanobacteria.... Agent: Davis Wright Tremaine LLP - San Francisco

20100028978 - In situ heat induced antigen recovery and staining apparatus and method: An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually... Agent: Dunlap Codding, P.C.

20100028979 - Methods and apparatus for organ support: An organ support apparatus includes: (a) a fluid circuit defining upstream and downstream legs adapted to be connected to an organ to be supported; (b) a circulation pump connected to the fluid circuit for circulating a process fluid through the fluid circuit and the organ; and (c) a first waveform... Agent: Trego, Hines & Ladenheim, PLLC

20100028980 - Real-time pcr in micro-channels: The present invention relates to methods for amplifying nucleic acids in micro-channels. More specifically, the present invention relates to methods for performing a real-time polymerase chain reaction (PCR) in a continuous-flow microfluidic system and to methods for monitoring real-time PCR in such systems.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20100028982 - Device for, an arrangement for and a method of analysing a sample: A device (100) for analysing a sample, the device (100) comprising a beam sensitive structure (101) adapted such that an electric property of a portion of the beam sensitive structure (101) is locally modified by a beam (102) impinging on the portion of the beam sensitive structure (101), and a... Agent: Philips Intellectual Property & Standards

20100028981 - Specimen colleciton and assay container: The present invention includes but is not limited to a specimen collection device that includes a chamber capable of collecting a specimen, a specimen passage slot, a reservoir, a reservoir seal, and a test device. A sample or specimen added to the chamber flows through the specimen passage slot into... Agent: Wilson, Sonsini, Goodrich & Rosati

20100028984 - Devices and methods for biochip multiplexing: The invention is directed to a method of analyzing a plurality of biochips. In particular, the method includes inserting a first biochip in to a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second... Agent: Morgan, Lewis & Bockius, LLP (sf)

20100028983 - Microwave accelerated assays: The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase heat thereby affecting the kinetics of a bioreaction therein.... Agent: Moore & Van Allen PLLC

20100028986 - Reaction container plate and reaction treatment apparatus: Disclosed herein is a reaction container plate which prevents the entry of foreign matter from the outside and the pollution of an outside environment. A reaction container plate (1) includes a sealed reaction container (5), a reaction container channel (15) connected to the reaction container (5), a sealed container (17)... Agent: Cheng Law Group, PLLC

20100028985 - Reaction vessel, reaction vessel processing apparatus and diagnostic apparatus: A reaction vessel suitable for automating of various measurements is provided. In a preferred embodiment, on the same side of plate-like substrate (10), sample injection part (12), typing reagent reservoir part (14) and mineral oil reservoir part (16) are provided as concaves, and further, multiple probe arrangement parts (18) are... Agent: Cheng Law Group, PLLC

20100028987 - Method for improving heat stability of composition containing water-soluble coenzyme-bound glucose dehydrogenase (gdh): The invention relates to a method for improving the heat stability of glucose dehydrogenase (GDH). The invention provides a method for preparing a glucose sensor with soluble flavin-bound GDH by providing a composition comprising soluble flavin-bound GDH at an acidic pH and heat drying the composition onto a glucose sensor.... Agent: Leydig Voit & Mayer, Ltd

20100028988 - Microplates with ultra-thin walls by two-stage forming: A multi-well plate with wells having ultra-thin walls and yet with sufficient structural rigidity to allow reliable use of the plate in automated instrumentation is formed by first forming a plate blank by injection molding, the blank being of a thickness that provides the desired rigidity, and then subjecting the... Agent: Townsend And Townsend And Crew, LLP

20100028989 - Monitor device and biological component-measuring device: This invention provides a monitor device capable of detecting possible abnormalities in body fluid withdrawal by a body fluid sampler and variations in the dilution when a withdrawn body fluid is diluted, and a living organism-measuring device with this monitor device. The former device includes a first optical sensor disposed... Agent: Darby & Darby P.C.

20100028990 - Sterile bioreactor bag with integrated drive unit: Flexible, sterilizable, disposable bioreactors are provided with integrated fluidic drive units that agitate media inside the bioreactor without introducing contamination. The bioreactor system (20) includes a flexible bag (202) with a fluid activated drive unit (204) in sealed cooperation with the bag (202).... Agent: Knobbe Martens Olson & Bear LLP

20100028991 - Asymmetric compound parabolic concentrator and related systems: Various embodiments disclosed herein provide for an asymmetric compound parabolic concentrator (ACPC), a liquid light guide, and an algae mixer. These embodiments may be used singularly or in combination, for example, as part of a bioreactor. In various embodiments an ACPC may be used to capture light without the aid... Agent: Townsend And Townsend And Crew, LLP

20100028992 - Cell culture device: The present invention discloses a cell culture device, including a container, and a carrying assembly; the container has an opening and holds the cell culture medium, and the carrying assembly is immersed in the cell culture solution from the opening of the container. The present invention also discloses a carrying... Agent: Bacon & Thomas, PLLC

20100028993 - Methods of producing peptides in plants and peptides produced thereby: Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein)... Agent: Dinsmore & Shohl LLP

20100028994 - Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells: A plurality of artificial red blood cell particles includes each particle of the plurality being substantially monodisperse and each particle having a largest common linear dimension of about 5 μm to about 10 μm. The particles can also have a modulus configured such that a particle of the plurality of... Agent: Alston & Bird LLP

20100028996 - Retroviral vectors for delivery of interfering rna: Provided herein are retroviral vectors for delivering interfering RNA into cells.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100028995 - Tetranectin trimerizing polypeptides: Tetranectin trimerizing polypeptides and fusion proteins including the polypeptides and therapeutic polypeptides and proteins. Trimeric complexes of the polypeptides and fusion proteins. Pharmaceutical compositions of the polypeptides, fusion proteins and the trimeric complexes.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100028997 - Method for culturing mesenchymal stem cell and method for producing biological tissue prosthesis: The purpose is to proliferate a mesenchymal stem cell to a sufficient degree while reducing the amount of blood serum contained in a biological tissue progenitor cell to be grafted, and to efficiently differentiate the mesenchymal stem cell into the biological tissue progenitor cell. There is provided a method for... Agent: Scully, Scott, Murphy & Presser, P.C.

20100028998 - Rnai expression constructs: The present invention provides compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.... Agent: Patton Boggs LLP

20100028999 - Methods, apparatus, and systems for fabrication of polymeric nano- and micro-fibers in aligned configurations: Provided herein are apparatus and systems for fabricating highly aligned arrays of polymeric fibers having isodiameters ranging from sub 50 nm to microns with lengths of several millimeters. The approach disclosed herein uses (e.g.) a micropipette to deliver polymeric solution which is collected in the form of aligned fibers on... Agent: Hirshman Law, LLC

20100029000 - Assembly and methods for cell or tissue culture and treatment: The invention provides an assembly designed under the multiwell plate make and methods of using the same for dynamic-based cell culture and pharmacokinetic-based cell treatment. The assembly comprises a multiwell plate and a lid which permits continuously adding and removing culture medium for culturing cells or tissues in vitro. The... Agent: Sci Head Pto Hui-hua Commercial Trading Building

20100029001 - Rotating transfer for complex patterning: A rotating transfer device for transfer of a film to a substrate at a gas-liquid interface, the rotating transfer device comprising a substrate holder holding the substrate, and a rotational positioning unit for rotating the substrate holder, the rotational positioning unit having a pivot to which the substrate holder is... Agent: Sylke Law Offices, LLC

20100029002 - Enhancement of hybridoma fusion efficiencies through cell synchronization: The present invention provides methods of enhancing hybridoma fusion efficiencies through cell synchronization of the fusion partners, in order to aid in production of antibodies.... Agent: Philip S. Johnson Johnson & Johnson

20100029003 - System and methods for identifying mirna targets and for altering mirna and target expression: The present invention generally relates to microRNAs such as vertebrate microRNA (miRNA), for example, mammalian miRNA. Various aspects of the invention are directed to the detection, production, or expression of miRNA. In one aspect, the invention provides systems and methods for identifying targets of miRNA sequences. For instance, in one... Agent: Wolf Greenfield & Sacks, P.C.

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