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Chemistry: molecular biology and microbiology January recently filed with US Patent Office 01/10Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 01/28/2010 > patent applications in patent subcategories. recently filed with US Patent Office
20100021879 - Compositions and methods for preserving red blood cells: The present invention provides methods, compositions and kits for storing red blood cells for extended periods of time. In particular, the present invention provides methods, compositions and kits for storing red blood cells for extended periods of time while preventing red blood cell storage lesions, retaining red blood cell deformability,... Agent: Casimir Jones, S.c.
20100021878 - Method for classifying and counting bacteria in body fluids: A method for distinguishing erythroblasts from bacteria by automated hematology analyzers, such as, for example, the CELL-DYN® 4000 automated hematology analyzer and the CELL-DYN® Sapphire™ automated hematology analyzer. Bacterial cells scatter light and fluoresce differently than do red blood cells, white blood cells, erythroblast nuclei, and platelets. Signals generated by... Agent: Paul D. Yasger Abbott Laboratories
20100021880 - Automated macromolecule sample preparation system: An apparatus for preparing a macromolecule sample from a complex liquid mixture includes a hydraulic system adapted for control by an automated controller, comprising a pump and one or more valves. The hydraulic system can be controlled by an automated controller to apply the liquid mixture to one or more... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20100021881 - Peptide combos and their uses: The invention provides reagents and methods for the accurate quantification of proteins in complex biological samples. Quantification is obtained by adding to a sample a peptide combo, which is essentially a collection of synthetic reference peptides. The synthetic reference peptides have a small mass difference when compared to the biological... Agent: Traskbritt, P.C.
20100021882 - method to detect virus related immunological markers for the diagnosis of respiratory tract infections: This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of respiratory tract viruses-related immunological markers in a serum sample, which can be used for the diagnosis of respiratory tract infections. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the... Agent: Weili Cheng
20100021901 - Compositions and methods for detecting analytes: Embodiments disclosed herein relate generally to probes (e.g. self-quenching probes), methods, and kits for detecting the presence of a target analyte using probes.... Agent: Knobbe Martens Olson & Bear LLP
20100021905 - Compositions and methods of selective nucleic acid isolation: The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.... Agent: Life Technologies Corporation C/o Intellevate
20100021909 - Concurrent optimization in selection of primer and capture probe sets for nucleic acid analysis: Disclosed is a method of iteratively optimizing two (or more) interrelated sets of probes for the multi-step analysis of sets of designated sequences, each such sequence requiring, for conversion, at least one conversion probe (“primer”), and each converted sequence requiring, for detection, at least one capture probe. The iterative method... Agent: Eric P. Mirabel
20100021922 - Dark quenchers for donor-acceptor energy transfer: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.... Agent: Morgan, Lewis & Bockius LLP (sf)
20100021883 - Detecting, measuring and controlling particles and electromagnetic radiation: A method is provided for detecting, measuring or controlling particles and/or electromagnetic radiation, comprising providing a deformable material containing a deformable aperture defining a path for particles or radiation, adjusting the deformable aperture to a prescribed geometry and/or size by deforming the deformable material to change at least one of... Agent: Mark D. Saralino (general) Renner, Otto, Boisselle & Sklar, LLP
20100021915 - High throughput dna sequencing method and apparatus: The present invention relates to a method for high throughput nucleic acid sequencing using a multi-bead flow cell and pyrophosphate sequencing, a sequencer capable of performing this method, and a kit of the pyrophosphate sequencing reagents.... Agent: David S. Resnick
20100021925 - Isolation of nucleic acids on surfaces: New processes and equipment to isolate and purify nucleic acids on surfaces are provided. The invention focuses on processes which use surfaces, for example, porous membranes, on which the nucleic acids are immobilized in a simple manner from the sample containing the nucleic acids and can be released again by... Agent: Leon R. Yankwich
20100021898 - Mammalian oocyte development competency granulosa markers and uses thereof: The present invention relates to the competence of oocytes for uterine implantation and development into living individuals. The invention more particularly relates to markers that are detected and measured in granulosa cells collected along with the oocytes during oocyte aspiration as it is done in assisted reproduction techniques. Markers include... Agent: Choate, Hall & Stewart LLP
20100021890 - Method for analyte detection using proximity probes: The present invention relates to a method for detecting an analyte in a sample, comprising (a) contacting said sample with at least one set of at least first, second and third proximity probes, which probes each comprise an analyte-binding domain and a nucleic acid domain and can simultaneously bind to... Agent: Knobbe Martens Olson & Bear LLP
20100021918 - Method for assaying action of antitumor agent using splicing defects as index: An object of the present invention is to provide a method, a probe, a primer, an antibody, a reagent, and a kit for assaying an action of a pladienolide derivative to a living subject. According to the present invention, there is provided a method for assaying an action of the... Agent: Fish & Richardson P.C.
20100021896 - Method for evaluating and comparing immunorepertoires: Disclosed is a method for amplifying RNA and/or DNA from immune cell populations and using the amplified products to produce an immune response profile and evaluate the possible correlation between a normal or abnormal immune response and the development of a disease such as an autoimmune disease, cancer, diabetes, or... Agent: Donna J. Russell
20100021902 - Method for methylation-selective amplification: Aspects of the invention relate to a method for methylation selective amplification. The method comprising a DNA treatment, wherein cytosine is converted to uracil, uracil sulfonate or another base having a different binding behavior than cytosine, while methylated cytosine remains unchanged, and the amplification of treated DNA in the presence... Agent: Kriegsman & Kriegsman
20100021923 - Method for the efficiency-corrected real-time quantification of nucleic acids: The present invention concerns a method for the quantification of a target nucleic acid in a sample comprising the following steps: (i) determination of the amplification efficiency of the target nucleic acid under defined amplification conditions, (ii) amplification of the target nucleic acid contained in the sample under the same... Agent: Townsend And Townsend And Crew, LLP
20100021899 - Method of assaying target substance in sample, aptamer molecule and method of constructing the same: A method for measuring a test substance whereby the test substance in a sample can be specifically measured without using an antibody against the test substance; an aptamer molecule used therefor; and a method for creating the aptamer are disclosed. An aptamer capable of hybridizing with an oligonucleotide when it... Agent: Birch Stewart Kolasch & Birch
20100021907 - Method of detecting a plurality of nucleic acids: The present invention provides a method of detecting a plurality of nucleic acid samples, includes a first step of preparing a nucleic acid sample detection device, a second step of preparing 1st to nth nucleic acid sample discrimination reagents, a third step of adding the 1st to nth nucleic acid... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100021886 - Methods and materials for identifying the origin of a carcinoma of unknown primary origin: The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into a linear discrimination analysis where the linear discrimination analysis normalizes the Biomarkers... Agent: Philip S. Johnson Johnson & Johnson
20100021910 - Methods and systems for microfluidic dna sample preparation: The present invention relates to methods and systems for microfluidic DNA sample preparation. More specifically, embodiments of the present invention relate to methods and systems for the isolation of DNA from patient samples on a microfluidic device and use of the DNA for downstream processing, such as performing amplification reactions... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100021912 - Methods of modulating lipid concentrations in eukaryotic cells: The present invention is based on the discovery of a set of genes that are involved in lipid-droplet formation and regulation. Accordingly, the present invention provides methods of increasing or decreasing lipid concentrations in eukaryotic cells by decreasing or increasing expression of one of these genes. Increased lipid concentrations may... Agent: Peters Verny , L.L.P.
20100021917 - Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease: This invention provides methods of diagnosing or predicting susceptibility to inflammatory bowel disease by determining the presence or absence of genetic variants. In one embodiment, a the invention is practiced by determining the presence or absence of NOD2 variants in an individual where the presence of NOD2 variants are indicative... Agent: Davis Wright Tremaine LLP/los Angeles
20100021916 - Microsatellite-based fingerprinting system for saccharum complex: This invention relates to Sacchanum spp. microsatellites and their flanking sequences, methods for microsatellite isolation, and methods applicable to use these sequences for fingerprinting and that may be used for applications such as: identification of Saccharum complex accessions, management of genrmplasm collections, selection of progenitors, distinction between varieties, identification of... Agent: Foley And Lardner LLP Suite 500
20100021893 - Modulators of lanosterol synthetase for treating acne or hyperseborrhea: An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of lanosterol synthetase (LSS), and the use of modulators of the expression or activity of this enzyme for... Agent: Buchanan, Ingersoll & Rooney PC
20100021892 - Modulators of sc4mol for treating acne or hyperseborrhea: An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of sterol-C4-methyl oxidase (SC4MOL), and the use of modulators of the expression or activity of this enzyme for... Agent: Buchanan, Ingersoll & Rooney PC
20100021884 - Mrna ratios in urinary sediments and/or urine as a prognostic and/or theranostic marker for prostate cancer: Described herein are methods and kits for prognosis of prostate cancer in a subject. The methods comprises: (a) determining the ratio of PCA3 and PSA expression in a urine sample and (b) correlating the value of the PCA3/PSA ratio with the aggressiveness and mortality risk of prostate cancer in the... Agent: Goudreau Gage Dubuc
20100021920 - Mutated abl kinase domains: The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317,... Agent: Novartis Corporate Intellectual Property
20100021921 - Mutated abl kinase domains: The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317,... Agent: Novartis Corporate Intellectual Property
20100021897 - Mycobacterium avium subspecies paratuberculosis (map) diagnostic test: The subject invention provides PCR primers and other nucleic acid sequences derived from Mycobacterium avium genes (IS1311 (Genbank accession # U16276), F57 (Accession # X70277) and ISMav2 (Accession # AF286339); these accession numbers and their respective descriptions are hereby incorporated by reference in their entirety and are provided in SEQ... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100021894 - Nanoparticle-based colorimetric detection of cysteine: The invention provides methods to detect cysteine which employ oligonucleotide functionalized nanoparticles.... Agent: Gregory T. Pletta Nanosphere, Inc.
20100021908 - Novel 2,5-diketo-l-gluconic acid reductases and method of use: Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described.... Agent: Danisco US Inc. Attention: Legal Department
20100021914 - Oligonucleotides for modulating target rna activity: The present invention describes oligonucleotides that bind to microRNA target sites in target RNAs, such as mRNAs. The oligonucleotides of the invention may mediate RNase H degradation of the target RNA, mediate RNAi of the target RNA or prevent microRNA regulation of the target RNA. The oligonucleotides of the invention... Agent: Foley And Lardner LLP Suite 500
20100021887 - Probe for tagging valuables based on dna-metal complex: Methods are disclosed involving the formation of complex DNA-Metal and the detection of the complex, such as by employing several analytical methods, e.g., X-Ray Fluorescence, FT-IR and Raman spectroscopy.... Agent: Dekel Patent Ltd., David Klein
20100021911 - Production host cell lines: The invention concerns the field of cell culture technology. The invention describes production host cell lines comprising vector constructs comprising a DHFR expression cassette. Those cell lines have improved growth characteristics in comparison to DHFR-deficient or DHFR-reduced cell lines such as CHO DG44 and CHO DUKX-B11. The invention especially concerns... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation
20100021919 - Production of polyhydroxyalkanoates from polyols: Recombinant processes are provided whereby additional genes are introduced into E. coli which have been genetically engineered to produce PHA so that the improved strains produce PHA homopolymers and copolymers directly from diols. In preferred embodiments, PHAs containing 4-hydroxybutyrate monomers are produced directly from 1,4-butanediol; PHAs containing 5-hydroxyvalerate are produced... Agent: Pabst Patent Group LLP
20100021885 - Reagent sets and gene signatures for non-genotoxic hepatocarcinogenicity: The invention discloses gene signatures for predicting onset of non-genotoxic hepatocarcinogenicity in a subject. The invention also provides methods, apparatuses and reagent sets useful for predicting non-genotoxic hepatocarcinogenicity based on expression levels of genes in specific gene signatures.... Agent: Howrey LLP-ca
20100021891 - Rgs2 genotypes associated with extrapyramidal symptoms induced by antipsychotic medication: The present invention identifies genotypes associated with resistance to extrapyramidal symptoms induced by antipsychotic drugs. The present invention further identifies genotypes associated with predisposition to the onset or aggravation of extrapyramidal symptoms induced by antipsychotic drugs and use thereof for assessment of patient populations. Specifically, the present invention relates to... Agent: Winston & Strawn LLP Patent Department
20100021906 - Salivary biomarkers for sjÖgren's syndrome: The present invention provides for the first time the identification of salivary protein and RNA factors that can be used in the detection of primary Sjögren's Syndrome. The present invention therefore provides methods of diagnosing and providing a prognosis for Sjögren's Syndrome, by examining relevant proteins (including certain autoantigens and... Agent: Townsend And Townsend And Crew, LLP
20100021888 - Screening for disease susceptibility by genotyping the ccr5 and ccr2 genes: Provided are compositions, methods and uses for identifying persons at an increased risk of infection by, transmission of, or accelerated progression of a disease caused by an HIV-1 virus. Diagnostic, prognostic and combined therapeutic kits are also provided.... Agent: Myers Bigel Sibley & Sajovec
20100021904 - Shielded cross-linking probes: The present invention relates to the use of nucleic acid probes to bind to targets. In some embodiments, the probe comprises a shielded cross-linking probe.... Agent: Knobbe Martens Olson & Bear LLP
20100021913 - Stimulus-elicited genomic profile markers of alzheimer's disease: The present invention relates to a method for diagnosing Alzheimer's Disease (AD) using PKC-elicited gene expression profiles PKC-activation elicits different genomic profiles in AD cells, as compared with control cells, which can he used to diagnose AD and individuals at risk for developing AD.... Agent: Milbank, Tweed, Hadley & Mccloy LLP
20100021924 - Transgenic animal and methods for decreasing cardiac cell death via cardiac-specific sir2alpha overexpression: The present invention relates to a transgenic animal and methods for increasing the expression or activity of Sir2α protein. An increase in the expression of Sir2α protein prevents stress- and age-related cardiac cell death thereby facilitating the treatment of cardiac diseases or conditions associated with aging.... Agent: Jane Massey Licata Licata & Tyrrell P.C.
20100021903 - Use of genetic determinants in cardiovascular risk assessment: The invention generally provides compositions and methods of using a subject's genetic information for the selection of prophylactic or therapeutic agents and treatment regimens, and related methods for assaying the risk of an adverse cardiovascular event in the patient.... Agent: Edwards Angell Palmer & Dodge LLP
20100021900 - Use of omentin 1 and omentin 2 in the diagnosis and treatment of disease: The present invention is directed to methods of diagnosing a disease or predicting an increased risk of a disease, such as obesity, obesity-dependent subacute inflammation, atherosclerosis, cardiovascular disease and a metabolic disease, by determining the levels of omentin 1 and 2 protein in a subject, or by determining the levels... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.
20100021889 - Using genetic polymorphisms of the bicd1 gene as a method for diagnosing and treating myopia: Using the BICD 1 gene as a method for diagnosing myopia and/or myopia related complications is provided. The method includes obtaining a biological sample from a subject, and determining at least one SNP genotype in the BICD1 gene in the biological sample, wherein the presence of the SNP genotype indicates... Agent: Pai Patent & Trademark Law Firm
20100021895 - Vectors for inducing homozygous mutations and methods of using same: The present invention provides vectors for inducing homozygous mutations in cells. Also provided are cells and populations of cells comprising a vector of the present invention. Further provided are methods of identifying cells with homozygous mutations. Also provided are methods of identifying agents that increase the frequency of homozygous mutations... Agent: Zirus, Inc. C/o Ballard Spahr LLP
20100021930 - Application of surface plasmon resonance technology to maternal serum screening for congenital birth defects: This invention discloses using SPR technology to simultaneously and quantitatively detect the presence of serum markers in pregnant women for the purpose of screening for congenital birth defects. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface... Agent: Weili Cheng
20100021933 - Cellomics systems: In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction... Agent: Antonelli, Terry, Stout & Kraus, LLP
20100021927 - Cholesterol loaded insect cell membranes as test systems for abc transporter proteins: The invention provides for a novel cholesterol loaded insect cell membrane preparation having an increased cholesterol level as compared to physiological cholesterol levels of insect cell membranes or to control insect cell membrane preparations without cholesterol loading, wherein said cholesterol loaded membrane preparation comprises an ABC transporter protein having an... Agent: Hahn & Voight PLLC
20100021929 - Detection of a biomarker of aberrant cells of neuroectodermal origin in a body fluid: Assays and kits for detecting aberrant cells of neuroectodermal origin in a body fluid of an individual, comprising testing for expression of GLAST1b as a biomarker of the cells are disclosed. Intact GLAST1b and/or fragments thereof may be detected in the fluid. Alternatively, another analyte indicative of the expression of... Agent: Edwards Angell Palmer & Dodge LLP
20100021931 - Fluorescence based reporter construct for the direct detection of tgf-beta receptor activation and modulators thereof: The invention comprises a fusion protein as sensor for TGF-beta receptor activity, a method for detecting receptor activity and to screening compounds for modulators of receptor activity. The fusion protein comprises a type I TGF-beta receptor, a circularly permutated fluorescent protein moiety (cpFP) and an activation state specific receptor binding... Agent: Quine Intellectual Property Law Group, P.C.
20100021935 - Goodpasture antigen binding protein and its detection: The present invention provides native Goodpasture antigen binding protein isoforms, monoclonal antibodies directed against such proteins, and methods for their use.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20100021926 - Method for rapid detection of lymphatic filariasis: There is provided by this invention a specific and sensitive diagnostic method for rapid detection of lymphatic filariasis. The method employs a combination of SXP/SXP-recombinant antigen, mouse monoclonal anti-human IgG4 antibody conjugated to a detection reagent and the technique of immunochromatography.... Agent: Lowe Hauptman Ham & Berner, LLP
20100021932 - Method for use of microdialysis: e
20100021928 - Methods and kits for diagnosing cancer: Methods and kits for diagnosing cancer in a subject is disclosed. The method comprises determining a level and/or activity of at least one saliva secreted marker in a saliva sample of the subject wherein an alteration in said marker with respect to an unaffected saliva sample is indicative of the... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20100021934 - Perlecan fragments as biomarkers of bone stromal lysis: A method for the detection in a body fluid of perlecan polypeptide fragments that are biomarkers of tumor metastasis, and antibodies for detecting these fragments are described. An immunoassay kit for detecting the presence of these biomarkers in a body fluid, such as serum or urine, is also described.... Agent: Ratnerprestia
20100021936 - Sensor for spores: A sensor for spores, comprises spore-binding ligands and, on or within the body of the sensor, a material that is responsive to Ca-DPA (calcium-dipicolinic acid) but not to a (or another) germinant.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100021938 - Diagnosis and prediction of alzheimer's disease: Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptide (Aβ) in the brain. Aβ is derived from amyloid precursor protein (APP) by β- and γ-secretases, with the β form (sAPPβ) being associated with the disease state, and the α form (sAPPα) being associated with the non-disease state. The... Agent: Fulbright & Jaworski L.L.P.
20100021937 - Method for detecting pathogens using microbeads conjugated to biorecognition molecules: A method and system are provided for the simultaneous detection and identification of multiple pathogens in a patient sample. The sample is combined with microbeads, which have been injected with quantum dots or fluorescent dye and conjugated to pathogen-specific biorecognition molecules, such as antibodies and oligonucleotides. Treatment options may be... Agent: Fasken Martineau Dumoulin LLP
20100021939 - Process for detecting enzyme activity in an immunoassay: m
20100021940 - Method for determining the activity of a protease in a sample: There is provided a method for determining the activity of a protease in a sample. The method comprises (i) admixing said sample with a substrate, wherein the substrate has the formula (1a) wherein: R1 is a hydrocarbyl group; R2 is a first peptide moiety; R3 is a second peptide moiety... Agent: Fish & Richardson P.C.
20100021941 - Methods of identifying modulators of ubiquitin ligases: Methods for identifying ubiquitin ligases and ubiquitin ligase modulators are disclosed. The methods comprise combining the components of a ubiquitylation reaction and using proteins that contain motifs that recognize ubiquitylated sites in the detection of ubiquitylation.... Agent: Woodcock Washburn LLP
20100021942 - Cell-free expression system for the detection of bacterial biofilms: Provided is a cell-free expression system and method for its use for detecting the presence of a bacterial biofilm on a surface, wherein the film comprises a) an exogenous quorum sensing protein or an exogenous nucleic acid sequence coding for a quorum sensing protein capable of selectively binding to a... Agent: Montgomery, Mccracken, Walker & Rhoads, LLP
20100021944 - Method for decreasing interference in results of immunochemical methods: Methods and materials are provided for decreasing or eliminating interference from molecules resulting from upstream immunochemical procedures, such as Immunoprecipitation, that employ an Immunoglobulin Binding Molecule (an IBM, e.g., Protein A) in subsequent downstream methods, such as Western Blot. An effective amount of a ligand of the IBM is used... Agent: Burleson Cooke L.L.P.
20100021943 - Methods for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide through three-dimensional interactions: The present invention relates to a method for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide in a biosample, which comprises the steps of: (a) preparing a carrier-capturing antibody conjugate by binding a capturing antibody to the surface of a solid phase carrier in a... Agent: The Nath Law Group
20100021945 - Determination of changes in concentration: The invention relates to the field of macrocyclic host systems and fluorescent dyes. In particular, the invention relates to apparatuses and methods for determining a change in the concentration of an analyte, in particular as a result of a catalysed reaction, preferably an enzymatically catalysed reaction and preferably in an... Agent: Sughrue Mion, PLLC
20100021946 - Method for preparing standard serum mixture for determining allergen activity and the use thereof: A method for preparing standardized serum mixture for determining allergen potency which comprises: 1) providing multiple serum samples from patients moderately hypersensitive to said allergen; 2) determining the relative content of sIgE against said allergen in each serum sample, obtaining the mean value of the relative content of sIgE of... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20100021947 - Detection meter and mode of operation: A method for performing an assay to determine the presence or concentration of an analyte contained in a sample of body fluid by using a device comprising at least one analyte quantification member and a sensor associated therewith, the method includes: applying a first sample to the analyte quantification member;... Agent: Buchanan, Ingersoll & Rooney PC
20100021948 - Medical diagnostic devices and methods: A medical diagnostic device includes a wirelessly transmitted time data receiver and processor. Associated devices, methods and functionality are also described.... Agent: Buchanan, Ingersoll & Rooney PC
20100021949 - Method for detecting transferase enzymatic activity: Methods and kits for detecting transferase activity in a sample by measuring ATP using a composition comprising an ATP-dependent bioluminescence-generating enzyme, a luminogenic molecule and one or more transferase quenching agents.... Agent: Michael Best & Friedrich LLP
20100021950 - Screening method for anti-diabetic compounds: The present invention relates to a method of identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of diabetes, the method comprising the steps of (a) contacting a test compound with a cell comprising a protein, wherein said protein (i) comprises or... Agent: Frommer Lawrence & Haug
20100021951 - Human brain carboxypeptidase b: A novel carboxypeptidase and the encoding gene thereof were successfully identified by screening a human hippocampus extract using brain-APP-cleaving activity as an index. This protein and its gene are useful in, for example, preventing, treating, examining, and diagnosing Alzheimer's disease, and such.... Agent: Townsend And Townsend And Crew, LLP
20100021953 - method for identifying an agent that modulates arginine transport in a chondrocyte: The present invention relates to an assay method for identifying an agent that modulates arginine transport in a chondrocyte comprising the steps of: (a) identifying an agent that modulates the activity and/or expression of CAT-2; and (b) measuring arginine transport in the chondrocyte in the presence or absence of said... Agent: Fish & Richardson P.C.
20100021956 - Fatty acid pattern analysis for predicting acute coronary syndrome: The present invention provides blood based methods for predicting risk of acute coronary syndrome in a subject.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20100021958 - Fluorescent ph detector system and related methods: Fluorescent pH detector and methods for measuring pH using the fluorescent pH detector.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20100021957 - Functionalized quantum dots and methods for preparing them: A quantum dot (QD) conjugate comprises a QD and a ligand conjugated with the QD, in which the ligand has at least one thiol and at least one other functional group. The QD conjugate may further comprise a bioactive agent covalently coupled to the ligand to form a bioactive agent-tagged... Agent: Ipc Intellectual Property Connections, Inc.
20100021954 - High capacity nanoparticulate immobilization surface: Disclosed are modified substrates having polyglutaraldehyde nanoparticulates for use, for example, in binding biomolecules, and methods of making and using the modified substrates.... Agent: Corning Incorporated
20100021955 - Modelling in yeast of the mitochondrial atp6 gene mutations responsible for narp syndrome in humans and uses thereof for screening for medicaments: Modified yeast cells comprising at least one mutation of the tryptophan 136 (W136), leucine 183 (L183), or leucine 247 (L247) codon of the mitochondrial ATP6 gene, responsible for NARP syndrome in humans and uses thereof for screening for medicaments that act against mitochondrial pathologies involving a deficiency in ATP production... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100021959 - High throughput screening method for assessing heterogeneity of microorganisms: The invention relates to the field of microbiology. Provided is a method which is particularly powerful for High Throughput Screening (HTS) purposes. More specific a high throughput method for determining heterogeneity or interactions of microorganisms is provided.... Agent: Nixon & Vanderhye, PC
20100021960 - Methods and compositions for pathogen detection using fluorescent polymer sensors: Compositions, methods and related apparatus, as can be used for selective pathogen detection and identification.... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator
20100021961 - Method for preparing biological scaffold material: Disclosed is a method for production of a bio-derived scaffold for use in regenerative medicine, which has a bio-compatibility and biodegradability and can self-organize and grow without causing calcification. The method comprises the steps of partially fixing a biological soft tissue with glutaraldehyde by cross-linking and incubating the partially fixed... Agent: Millen, White, Zelano & Branigan, P.C.
20100021962 - Use of a plastid-lipid associated protein promoter (pap promoter) for heterologous gene expression: Use of a plastid-lipid associated protein promoter (PAP promoter) for heterologous expression of genes in plants of the genus Tagetes.... Agent: Connolly Bove Lodge & Hutz, LLP
20100021963 - Genetic incorporation of unnatural amino acids into proteins in mammalian cells: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins in mammalian host cells, for example, primate host cells and rodent host cells. The invention provides, for example but not limited to, translation systems that include host cells (e.g., primate or... Agent: Quine Intellectual Property Law Group, P.C.
20100021964 - Microorganism for producing recombinant pig liver esterase: The present invention relates to a microorganism which comprises at least one copy of a polynucleic acid sequence which is foreign to the host and which encodes a protein having an enzymic activity, and comprises a chaperone system which assists the expression of the protein in the form of an... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100021965 - Protein expression in rodent cells: A method is described for the expression of heterologous polypeptides in rodent cells. The method comprises the oriP/EBNA-1 episomal replication and maintenance system of the Epstein-Barr-Virus (EBV). With the stable integration of an EBNA-1-protein expression cassette under the control of a promoter into the genome of a rodent cell an... Agent: Hoffmann-la Roche Inc. Patent Law Department
20100021967 - Alpha factor signal peptide for producing a polypeptide: The present invention relates to a method for producing a polypeptide comprising using a variant alpha factor signal peptide having a substitution in position 9 resulting in a substitution of an A to either T, S, H, I, F, E, or G. The invention further relate to nucleic acid constructs... Agent: Novozymes North America, Inc.
20100021966 - Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof: The present invention is directed generally to recombinant methods for making a desired polypeptide. These method(s) yield a polypeptide product containing reduced levels of isoform impurities thereof. In particular, the present invention is directed to (1) a recombinant method for preparing growth hormone with reduced isoform impurities thereof and (2)... Agent: Pfizer Inc. Patent Department
20100021968 - Novel chlorella species and uses therefor: The present invention relates to algal species and compositions, methods for identifying algae that produce high lipid content, possess tolerance to high CO2, and/or can grow in wastewater,, and methods for using such algae for lipid production, wastewater remediation, waste gas remediation, and/or biomass production.... Agent: Davis Wright Tremaine LLP - San Francisco
20100021969 - Extraction of phytochemicals by enzymatic hydrolysis: A process for extracting phytochemicals from plants. The process generally comprises controllably slurrying a selected plant material in a volume, adding a selected enzyme the slurry while it is controllably agitated, then heating the controllably agitated slurry-enzyme mixture to a temperature from the range of 40° C. to 110° C.,... Agent: Fulbright & Jaworski L.L.P. Attn: MnIPDocket
20100021972 - Method and apparatus for amplifying nucleic acids: A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a... Agent: Cantor Colburn, LLP
20100021971 - Method to remove repetitive sequences from human dna: The invention discloses an innovative method to deplete repetitive sequences from human DNA. The method comprises (a) providing a source DNA containing both unique and repetitive sequences and sonicating the source DNA to smaller fragments; (b) providing a driver DNA containing sequences complementary to the repetitive sequences of the source... Agent: Weili Cheng
20100021970 - Nucleic acid amplification using a reversibly modified oligonucleotide: The present invention provides a method for amplification of a target nucleic acid sequence or signal, wherein an amplification reaction mixture is used which contains at least one reversibly modified oligonucleotide having a non-hydroxyl group 3′ end which can be converted into a hydroxyl 3′ end upon exposure to a... Agent: Ballard Spahr LLP
20100021973 - Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction: The present invention concerns preparation of DNA molecules, such as a library, using a stem-loop oligonucleotide. In particular embodiments, the invention employs a single reaction mixture and conditions. In particular, at least part of the inverted palindrome is removed during the preparation of the molecules to facilitate amplification of the... Agent: Fulbright & Jaworski, LLP
20100021974 - Method for preparation of crna: It is an object of the present invention to provide a method for preparing a cRNA, the method being capable of preventing decrease in cRNA yield. In order to achieve the object, the method comprises (a) a step of performing a reaction for preparing a single-stranded cDNA by treating with... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20100021975 - Process for producing xylo-oligosaccharides: The invention relates to a process for producing xylo-oligosaccharides, comprising the steps of cold caustic extraction (CCE) of a pulp obtained by a cooking process; purifying at least a portion of the press liquor forming in the cold caustic extraction stage using a membrane separation process, preferably nano- or ultrafiltration;... Agent: Fitzpatrick Cella Harper & Scinto
20100021976 - Production of polyunsaturated fatty acids, novel biosynthesis genes, and novel plant expression constructs: The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention furthermore relates to the use of nucleic acid sequences SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 11 encoding polypeptides... Agent: Connolly Bove Lodge & Hutz, LLP
20100021977 - Process for preparing alkyl (meth)acrylates using an enzymatic cyanohydrin hydrolysis: The present invention relates to a process for preparing alkyl(meth)acrylates, characterized in that the process has a step in which a cyanohydrin is hydrolysed with an enzyme whose residual activity after the conversion of methacrylonitrile in the presence of 20 mM cyanide ions at 20° C. after 30 min is... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100021978 - Methods and organisms for production of 3-hydroxypropionic acid: A non-naturally occurring microbial organism having a 3-hydroxypropanoic acid (3-HP) pathway includes at least one exogenous nucleic acid encoding 3-HP pathway enzyme expressed in a sufficient amount to produce 3-HP. The 3-HP pathway includes a 2-keto acid decarboxylase, a CoA-dependent oxaloacetate dehydrogenase, or a malate decarboxylase. A method for producing... Agent: Mcdermott, Will & Emery
20100021979 - Apparatus and process for production of biogas: A process and an apparatus for the manufacture of biogas and a solids fraction from an organic waste feedstock is provided. The process involves thermal hydrolysis of the organic waste feedstock at a temperature from about 100 to about 220° C., a pressure from about 5 to about 20 bars,... Agent: Patent Correspondence Arnall Golden Gregory LLP
20100021980 - Hybrid process for the production of biofuel: A method of producing a biofuel from biomass is provided. In one embodiment, the biofuel production process is an ethanol production process. Various embodiments of the invention include features such as application of a shock wave to biomass, variations in composition of biomass feed stock, continuous fermentation, and anaerobic digestion... Agent: Kean, Miller, Hawthorne, D'armond, Mccowan & Jarman, L.L.P.
20100021981 - Process and a plant for recycling carbon dioxide emissions from power plants into useful carbonated species: A process is disclosed for recycling carbon dioxide emissions from a fossil-fuel power plant into useful carbonated species The process primarily comprises the steps of: a) burning the fossil fuel, thereby generating heat and a hot exhaust gas containing CO2; and b) converting the heat into energy. The process is... Agent: Ware Fressola Van Der Sluys & Adolphson, LLP
20100021982 - Light-sensitive constructs for inducing cell death and cell signaling: A light-sensitive G-protein coupled receptor includes a light sensitive extracellular domain and a hetorologous intracellular domain capable of modulating an intracellular signaling pathway.... Agent: Tarolli, Sundheim, Covell & Tummino, LLP
20100021983 - Laser dosimetry for the optoperforation of single cells: A method of optoperforation of the membrane of a cell by application of laser pulses characterized by focusing the pulsed laser beam onto the cell membrane to be perforated, applying a series of laser pulses of predetermined pulse energy, measuring the oscillation time of the bubbles formed in the laser... Agent: Diederiks & Whitelaw, PLC
20100021985 - Mechanical process for creating particles in fluid: A method of producing at least one of microscopic and submicroscopic particles includes providing a template that has a plurality of discrete surface portions, each discrete surface portion having a surface geometry selected to impart a desired geometrical property to a particle while being produced; depositing a constituent material of... Agent: Venable LLP
20100021984 - Microfluidic droplet encapsulation: Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid... Agent: Fish & Richardson PC
20100021986 - Apparatus and method for introducing substance into cells: Provided is a cell chip for exposing to a portion of each of cells microdroplets dispensed with an inkjet printer or the like in a screening test of the effect of a substance on cells by using an apparatus for introducing the substance into cells including: a cell-immobilizing support including... Agent: Fitzpatrick Cella Harper & Scinto
20100021987 - Compositions, methods, and kits for enhancing protein expression: The inventive subject matter relates to novel compositions, methods, and kits for enhancing the expression, solubility, and isolation of heterologous proteins. Further, the inventive subject matter relates to methods for generating proteins with novel N-terminal amino acids, unlike wild-type proteins which always are translated from mRNA with methionine at the... Agent: Dann, Dorfman, Herrell & Skillman
20100021988 - Pectate lyases, nucleic acids encoding them and methods for making and using them: The invention is directed to polypeptides having pectate lyase (pectinase) activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as pectate lyases to catalyze the beta-elimination or hydrolysis of pectin and/or polygalacturonic acid, such as 1,4-linked... Agent: Verenium Corporation Intellectual Property Department
20100021989 - Compositions and methods of controlling and administering redox specific forms of drugs, foods and dietary supplements: The formulations have an antimicrobial, antiviral, and anti-pathogenic composition that combines, in various forms, a redox-active polyphenol, an oxidizing agent, and/or a redox-active, transition metal ion and/or electrochemical potential. The composition relates to methods for decreasing or eliminating the infectivity, morbidity, and rate of mortality associated with a variety of... Agent: Catalyst Law Group, Apc
20100021990 - High throughput bioprocess apparatus: The invention relates to a multiple bioreactor system comprising a plurality of bioreactors, a source of pressurised fluid, and distribution means for distributing the fluid to the bioreactors, wherein the bioreactor system includes backpressure creating means presented by, before or after each bioreactor and the source of pressurised fluid such... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20100021991 - Methods for producing modified glycoproteins: Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower... Agent: Merck And Co., Inc
20100021992 - Enzymatic decomposition of residual formamide in polymers: Method for reducing the formamide content of preparations (P) prepared from N-vinylformamide monomers by polymerization.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100021993 - System for assembling and utilizing sensors in containers: A system for measuring parameters in a container is disclosed. A container has a solution. A protective layer is deposited over at least one sensor and at least one wall of the container, where the protective layer is attached to the wall of the container to form a seal between... Agent: Ge Healthcare Bio-sciences Corp. Patent Department
20100021994 - Apparatus for determining the termination of fat digestion and fat tissue digestion apparatus: To enable to yield a group of fat-derived stem cells of constant quality regardless of the individual difference in fat tissue. It is intended to provide an apparatus for determining the termination of fat digestion (1) for use in a fat tissue digestion apparatus which digests a fat tissue by... Agent: Scully Scott Murphy & Presser, PC
20100021995 - Biological products: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the... Agent: Cozen O'connor, P.C.
20100021996 - Genetically altered anti-body producing cell lines with improved antibody characteristics: Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. Cells may be selected for expression of activation-induced cytidine deaminase (AID), stimulated to produce AID, or manipulated to express AID for further enhancement of hypermutability. These methods are useful for generating genetic diversity... Agent: Woodcock Washburn LLP
20100021997 - Biologically active recombinant human saposin c and psap: The invention relates to the establishment of expression vectors replicable in a mammalian cell, including a DNA sequence encoding human prosaposin (PSAP) or Saposin C, operably linked with regulatory DNA capable of effecting the expression of the PSAP and Saposin C DNA coding sequence in the cells. In addition, the... Agent: Adams And Reese LLP
20100021998 - Defined cell culturing surfaces and methods of use: In one aspect, there is provided a cell culturing substrate including: a cell culture surface having a film attached thereto, wherein the film includes one or more plasma polymerized monomers; and a coating on the film-coated surface, the coating deposited from a coating solution comprising one or more extracellular matrix... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20100021999 - Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures prepared using same: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20100022000 - Increasing cell culture population doublings for long-term growth of finite life span human cell cultures: Cell culture media formulations for culturing human epithelial cells are herein described. Also described are methods of increasing population doublings in a cell culture of finite life span human epithelial cells and prolonging the life span of human cell cultures. Using the cell culture media disclosed alone and in combination... Agent: Lawrence Berkeley National Laboratory
20100022001 - Cationic liposomes and method of use: Highly efficient cationic liposomes are provided as a system for the delivery to cells of agents or compounds, such as, compounds capable of silencing a target protein and enzyme substrates. The cationic liposomes can be used in methods of detecting the inhibition activity or apparent activity of a target protein... Agent: Life Technologies Corporation C/o Intellevate
20100022002 - Method for inhibiting the formation of set1 family core complexes: Disclosed in this specification is a method for inhibiting the formation of SET1 family core complexes. A guanidinium-containing molecule is used to competitively inhibit the binding of the N-SET region of a SET1 protein to WDR5, thus inhibiting the formation of the SET1 family core complex. The guanidinium-containing molecule may... Agent: Hiscock & Barclay, LLP
20100022003 - Therapeutic cell medicine comprising skin tissue derived stem cell: Provided is a cell therapeutic agent for treatment of neurological disorders, comprising skin-derived progenitor cells (SPCs). More specifically, the present invention provides a cell therapeutic agent for treatment of neurological disorders, comprising skin-derived progenitor cells (SPCs) isolated from skin tissues and a method for differentiation of the skin-derived progenitor cells... Agent: Christie, Parker & Hale, LLP
20100022004 - Modified reconstituted basement membrane composition for assay system: A modified reconstituted extracellular matrix composition is provided herein. The composition includes an extracellular matrix and at least one exogenous component selected from heparin, fibronectin and laminin. The composition may have a basic pH. Additionally, provided herein is a cell culturing system including a substrate and a coating thereon of... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20100022005 - Adipose stromal stem cells for tissue and vascular modification: Methods are provided for isolating adipose derived stromal cells from an animal by extracting adipose tissue from the patient, dissecting the tissue, dissociating the tissue into a cell suspension, removing the adipocytes, exposing the cell suspension to red cell lysis buffer, and isolating adipose derived stromal cells.... Agent: Nixon Peabody LLP
20100022006 - Gamma satellite insulator sequences and their use in preventing gene silencing: Regulatory elements, specifically insulators and transgene constructs containing insulator nucleic acid sequences, are disclosed herein. Methods of using insulators and transgene constructs including insulators to inhibit, delay, or prevent gene silencing are also disclosed herein.... Agent: Klarquist Sparkman, LLP01/21/2010 > patent applications in patent subcategories. recently filed with US Patent Office
20100015592 - Device for transporting an organ: The invention relates to a device for transporting an organ having a container for organs, a gas-driven pump connected to the container and conduits for circulating a liquid and/or gas through the container, and a controller for controlling the pump. There are pressure sensor means in the liquid output conduit... Agent: The Webb Law Firm, P.C.
20100015593 - Method for producing a composition for promoting survival of transplanted hematopoietic stem cell: HLA matched activated lymphocytes in mononuclear cells separated from peripheral blood or umbilical cord blood are proliferated and activated. After separating and collecting, the HLA matched activated lymphocytes are employed as the main component of a composition for promoting survival of transplanted hematopoietic stem cells. The obtained composition is widely... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20100015594 - Human papilloma virus (hpv) detection using nucleic acid probes, microbeads and fluorescent-activated cell sorter (facs): The present invention relates generally to the field of diagnostic and detection assays. More particularly, the present invention provides methods, and reagents including biochips for detecting the presence of, or distinguishing between, one or more analytes in a sample.... Agent: Knobbe Martens Olson & Bear LLP
20100015598 - Light emission modifiers and their uses in nucleic acid detection, amplification and analysis: The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and reagents exploit advantageous properties of thiazine dyes and diazine dyes.... Agent: Roche Molecular Systems, Inc. Patent Law Department
20100015595 - Phage particle diagnostic reagents: The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20100015597 - Production of biological carriers for induction of immune response and inhibition of viral replication: This application provides a method to form non-infectious Biological Carrier that may be used to deliver signals to cells either in vitro or in vivo. The Biological Carriers are inactivated virus particles that have been specifically modified to give biological properties different from the virus particles deriving from an unmodified... Agent: Patentique PLLC
20100015596 - Rs virus detecting kit using anti-rs virus monoclonal antibody, immuno-chromatographic test device, and new anti-rs virus monoclonal antibody: A kit or an immuno-chromatographic test device for detection of respiratory syncytial virus (RSV), comprising at least an RSV F protein-recognizing anti-RSV monoclonal antibody produced by hybridoma RSF2-412. An anti-RSV monoclonal antibody recognizing an RS virus F protein, which is selected from the group consisting of an antibody produced by... Agent: Sughrue Mion, PLLC
20100015628 - Ambient temperature stable chemical/biological reagents on membranes or filters: The present invention provides a biological sample preparation system including ambient temperature stable reagent mixture and a separation filter or membrane. In particular, the system includes a dried reagent in a glassy, porous state, on top of a separation column, whereby sample preparation is streamlined and simplified. Also provided are... Agent: Ge Healthcare Bio-sciences Corp. Patent Department
20100015608 - Binary deoxyribozyme probes for nucleic acid analysis: New binary deoxyribozyme or ribozyme probes and methods are described for nucleic acid analysis, which allows the detection of nucleic acids under mild physiologic conditions with extraordinary specificity and high sensitivity to single nucleotide mismatches without PCR amplification.... Agent: Ditthavong Mori & Steiner, P.C.
20100015601 - Biological confirmation and detection system: The present disclosure describes a method and apparatus for collecting samples of particles from air or other gases at one or more monitored locations, and identifying in real-time whether biological agents, such as bacterial or viral pathogens, are present in the samples. The apparatus preferably uses a liquid-assisted collector to... Agent: Life Technologies Corporation C/o Intellevate
20100015620 - Cancer-linked genes as biomarkers to monitor response to impdh inhibitors: Sets of biomarker genes useful for monitoring exposure and response to anti-tumor agents that inhibit IMPDH and related biomolecules are disclosed along with methods for identifying such sets of genes, methods of using such sets to identify additional therapeutic agents as well as methods for stratifying patients into groups that... Agent: Alan J. Grant Carella Byrne Bain Gilfillan Cecchi Stewart & Olst
20100015614 - Chip-based device for parallel sorting, amplification, detection, and identification of nucleic acid subsequences: An apparatus for chip-based sorting, amplification, detection, and identification of a sample having a planar substrate. The planar substrate is divided into cells. The cells are arranged on the planar substrate in rows and columns. Electrodes are located in the cells. A micro-reactor maker produces micro-reactors containing the sample. The... Agent: Lawrence Livermore National Security, LLC
20100015604 - Composition and method for determination of ck19 expression: Disclosed is a method for quantitative determination of CK-19 mRNA positive cells in a biological sample. The method can be used, for instance, with peripheral blood to detect cancer in a patient. In one embodiment, the method can be used to detect the cancer before initiation of adjuvant treatment, thereby... Agent: Edwards Angell Palmer & Dodge LLP
20100015631 - Concatameric ligation products: compositions methods and kits for same: The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form... Agent: Life Technologies Corporation C/o Intellevate
20100015625 - Ctip2 expression in squamous cell carcinoma: The present disclosure provides methods of diagnosing and staging squamous cell carcinomas, for instance head and neck (HNSCC), by detecting chicken ovalbumin upstream promoter-transcription factor-interacting protein 2 (CTIP2) expression. For example, it is demonstrated herein that expression of CTIP2 is increased in SCC relative to a corresponding normal sample. Also... Agent: Klarquist Sparkman, LLP
20100015610 - Diagnostic screening methods for disorders of the endoplasmic reticulum-to-golgi trafficking of proteins: The invention relates to methods of diagnosing Cranio-lenticulo-sutural dysplasia and other disorders that occur as a result of defective endoplasmic reticulum-to-Golgi trafficking using immunofluorescence based screening tests using antibodies against protein disulfide isomerase.... Agent: Edwards Angell Palmer & Dodge LLP
20100015618 - Dna fragment used as attached to 5' end of primer used in nucleic acid amplification reaction and use of dna fragment: A method is provided which enables quick, convenient, inexpensive, and high sensitivity confirmation of nucleic acid amplification after a nucleic acid amplification reaction. The DNA fragment in accordance with the present invention is a single-stranded DNA fragment containing a hairpin structure which in turn contains a bulge, wherein the DNA... Agent: Morrison & Foerster LLP
20100015623 - Genetic loci associated with mechanical stalk strength in maize: The invention relates to methods and compositions for identifying and for selecting maize plants with mechanical stalk strength characteristics. The methods use molecular markers to identify and select plants with increased mechanical stalk strength or to identify and counter-select plants with decreased mechanical stalk strength. Maize plants generated by the... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20100015605 - Hepatocellular carcinoma classification and prognosis: Methodology for the in vitro classification and/or prognosis of hepatocellular carcinoma (HCC) from a HCC sample is based on the determination of the expression profile of particular gene combinations.... Agent: Buchanan, Ingersoll & Rooney PC
20100015616 - High speed, high fidelity, high sensitivity nucleic acid detection: The present invention provides methods, compositions, and kits for nucleic acid detection.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20100015615 - Identification and isolation of adult stem cells and related methods of use: Inhibitor of DNA Binding-1 (Id-1) is a marker protein found in stem cells, including adult stem cells, which can be used an indicator of the “stem-ness” of the cells. This allows Id1 expression to be used in a method for identifying cells as potential stem cells involving the step of... Agent: Larson & Anderson, LLC Re: Msk
20100015599 - Isolated reductive dehalogenase genes: The invention is directed to novel reductive dehalogenase genes encoding for reductive dehalogenases which are capable of dehalogenating halogenated organic compounds and may be useful in the bioremediation of pollutants. In particular, the invention provides an isolated polynucleotide of a novel vinyl chloride dehalogenase gene (bvcA). The novel vinyl chloride... Agent: Darby & Darby P.C.
20100015629 - Light emission modifiers and their uses in nucleic acid detection, amplification and analysis: The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and reagents exploit advantageous properties of thiazine dyes and diazine dyes.... Agent: Roche Molecular Systems, Inc. Patent Law Department
20100015630 - Light emission modifiers and their uses in nucleic acid detection, amplification and analysis: The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and reagents exploit advantageous properties of thiazine dyes and diazine dyes.... Agent: Roche Molecular Systems, Inc. Patent Law Department
20100015609 - Method for determining the ratio of two distinct peptides or polynucleic acids: The invention relates to a method for determining the ratio of two distinct target-peptides or polynucleic acids comprising: a) obtaining a sample containing said two distinct target-peptides or polynucleic acids, b) providing a precursor-peptide or precursor-polynucleic acid, comprising the two distinct target-peptides or -polynucleic acids in a known ratio, wherein... Agent: Birch Stewart Kolasch & Birch
20100015600 - Method for diagnosing and treating crohn's disease: The invention concerns an in vitro method for diagnosing Crohn's disease, or for determining predisposition in a person to develop Crohn's disease, by detecting an overexpression of the CD66c receptor in subjects suffering from said disease or at risk. The invention also concerns preventive or curative treatment of Crohn's disease.... Agent: Stites & Harbison PLLC
20100015621 - Method for direct amplification from crude nucleic acid samples: The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the direct amplification of the nucleic acids in a crude sample with minimal sample purification.... Agent: Life Technologies Corporation C/o Intellevate
20100015632 - Method for examining colorectal cancer and colorectal adenoma: The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. There... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20100015619 - Method of detecting genomic aberrations for prenatal diagnosis: This invention relates to assays used to detect and confirm genomic aberrations, such as chromosomes 13, 18, 21, X and Y aneuploidy as well as 22q11.2 deletions, for prenatal diagnosis. For the detection, combined STR markers (all tetra-nucleotide repeats) are employed to cover different chromosome regions. For the confirmation step,... Agent: Weili Cheng
20100015612 - Methods and systems for evaluation of hydrocarbon reservoirs and associated fluids using biological tags and real-time pcr: This invention relates in general to characterizing hydrocarbon reservoirs and/or determining flow properties of fluids associated with the reservoir-including fluids introduced into the reservoir to provide for hydrocarbon extraction-using biological tags and real-time polymerase chain reactions for tag detection. In embodiments of the present invention, one or more biological tags... Agent: Schlumberger-doll Research Attn: Intellectual Property Law Department
20100015606 - Microfluidic droplet queuing network: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20100015622 - Molecular beacon-based methods for detection of targets using abscription: The present invention provides methods for detecting targets using an Abscription assay that exploits molecular beacon-based detection technology. The methods of the invention are highly sensitive and can be performed on a NanoDrop scale and can be multiplexed for simultaneous detection of multiple targets.... Agent: The Law Office Of Jane K. Babin Professional Corporation
20100015626 - Multiplex nucleic acid reactions: The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.... Agent: Mcdermott, Will & Emery
20100015607 - Nanoreporters and methods of manufacturing and use thereof: The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to coded, labeled probes that are capable of binding to and identifying target molecules based on the probes' label codes. Methods of making and using such... Agent: Seed Intellectual Property Law Group PLLC
20100015617 - Nucleic acid amplification method: Disclosed is a nucleic acid amplification method which is based on a new principle and enables to amplify a nucleic acid having a specific nucleotide sequence in a simple manner, within a short time and with efficiency. The nucleic acid amplification method comprises the steps of: (a) conducting a DNA... Agent: Marshall, Gerstein & Borun LLP
20100015624 - Peptide having ability to activate cancer-related gene: To provide a cancer diagnostic reagent for determining malignancy of a cancer patient or a cancer cell and a tendency of canceration of a healthy subject, the reagent including a peptide having an ability to activate a cancer-related gene and extracted from cell membrane surfaces of human squamous-cell carcinoma cells... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20100015611 - Reaction monitoring: The invention provides a method and apparatus for detecting a signal of a specific spectrum emitted in the course of a chemical or biochemical reaction. The method comprises conducting the reaction in a reaction vessel, which is arranged so that light emanating from the reaction vessel is received by a... Agent: Townsend And Townsend And Crew, LLP
20100015602 - Reverse transcription and amplification of rna with simultaneous degradation of dna: The invention relates to a method for processing RNA, in particular, a RNA reaction method and kits for carrying out said RNA reaction method.... Agent: Ballard Spahr LLP
20100015627 - Selection method: The current invention comprises a method for the selection of a mammalian cell by transfecting a mammalian cell with a nucleic acid comprising a part of a nucleic acid encoding a polypeptide that catalyzes an α1,6-glycosidic bond formation between fucose and an asparagine-linked N-acetylglucosamine and cultivating the transfected mammalian cell... Agent: Hoffmann-la Roche Inc. Patent Law Department
20100015613 - Systems and methods for improving protein and milk production of dairy herds: The present invention provides for a direct correlation between milk production in livestock animals and the presence of alleles of a gene encoding an adipocyte-specific polypeptide, termed leptin, which gene is hereinafter referred to as ob. The invention also provides novel compositions consisting essentially of specific oligonucleotides that are useful... Agent: Andrus, Sceales, Starke & Sawall, LLP
20100015634 - In situ lysis of cells in lateral flow immunoassays: Devices and methods incorporate lysis agents into a point-of-care testing device. The sample is loaded, and then the sample travels until it encounters a lysis agent. The lysis agent is preferably pre-loaded onto the collection device. In a preferred embodiment, the initially lysis agent is localized between the sample application... Agent: Brown & Michaels, PC 400 M & T Bank Building
20100015633 - Methods and kit for analyte detection: A method includes binding a probe to an analyte present in a sample, wherein the probe comprises a binder bonded to a metal particle that is capable of releasing metal ions when contacted with a reagent solution. The method includes contacting the metal particle with the reagent solution to release... Agent: General Electric Company Global Research
20100015638 - Method for production of antibody directed against cell membrane surface antigen epitope and assaying method: Disclosed are a method for determining the affinity of an antibody capable of binding to a cell membrane surface antigen for the antigen; and a method for assaying or screening an antibody capable of binding to a cell membrane surface antigen by utilizing the determination method. In the determination of... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20100015639 - Methods and kits to detect and monitor ovarian cancer and preeclampsia: The present invention provides methods and kits related to a prognostic, and, in certain embodiments, diagnostic indicator for ovarian cancer which comprises measuring the level of MUC16 bound to immune cells. The level of MUC16 bound to immune cells can by itself be an indicator of disease regression or recurrence,... Agent: Quarles & Brady LLP
20100015640 - Nucleic acid, polypeptide and its use: Novel chimeric proteins functional to screen for umami taste modulators, the corresponding nucleic acid sequences, expression vectors, transfected host cells, and screening methods for modulators and enhancers of the umami taste response employing the aforementioned are provided.... Agent: Curatolo Sidoti Co., Lpa
20100015642 - B7-h1 and survivin in cancer: Methods of determining prognosis of a subject with cancer by assessing expression of B7-H1 and survivin in combination.... Agent: Fish & Richardson P.C.
20100015641 - Diagnostic agent for tumor: The present invention provides a diagnostic agent and a diagnostic kit for tumor such as lung cancer, cervical cancer, gastric cancer, breast cancer or the like, which comprise an antibody against MCAF1 or MCAF2; and a diagnostic method using an antibody against MCAF1 or MCAF2.... Agent: Morgan Lewis & Bockius LLP
20100015643 - Method of quantitative determination of antigen protein and quantitative determination kit therefor: There is provided a method of quantitative determination using a flow cytometer, with which quantitative determination of cell surface protein can be effected more accurately than with current methods. The inventors have achieved the present invention by providing a method of quantitative determination of sites, per cell of a test... Agent: Sughrue Mion, PLLC
20100015635 - Immobilisation of fluorescent proteins: The present invention concerns a method of detection of an analyte in which a protein capable of binding the analyte and comprising a fluorescent energy label and an energy acceptor moiety capable of accepting energy emitted by the label or protein by Forster energy transfer (FRET), is exposed to incident... Agent: Whitham, Curtis & Christofferson, P.C.
20100015636 - Colloidal metal conjugates: Colloidal metal conjugates can be produced in high concentrations suitable for direct use, for example, in immunoassays. The colloidal metal conjugates can be used in devices for qualitative, semi-quantitative, or quantitative determination of the presence of compounds in samples, including biological samples.... Agent: Steptoe & Johnson LLP
20100015637 - Pigf-1 assay and kits and components thereof: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.... Agent: Paul D. Yasger Abbott Laboratories
20100015648 - Detection of ngal in chronic renal disease: Methods of assessing the ongoing kidney status in a subject afflicted with chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in fluid samples over time is disclosed. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine and... Agent: Hasse & Nesbitt LLC
20100015645 - Il-8 as biomarker for the detection of urolithiasis: Disclosed herein is a method for the detection or preliminary screening of urolithiasis, comprising: detecting the IL-8 level and the creatinine level in a urine sample taken from a human subject suspected to have urolithiasis; obtaining a creatinine-normalized IL-8 level in the urine sample by normalizing the detected IL-8 level... Agent: Lando & Anastasi, LLP
20100015647 - Method and kit for the detection of heparin-dependent antibodies and the diagnosis of immune or autoimmune pahtologies potentiated by heparin such as heparin-induced thrombocytopenia: The invention relates to a method for the detection of heparin-dependent antibodies and the diagnosis of immune or autoimmune pathologies potentiated by a heparin substance, such as thrombocytopenia induced by heparin (HIT type II) as inducer drug. The invention is characterized in that said method comprises the steps consisting in:... Agent: Trego, Hines & Ladenheim, PLLC
20100015646 - Portable, point-of-care, user-initiated fluidic assay methods and systems: Methods and systems to perform point-of-care, user-initiated fluidic assays, using substantially self-contained, portable, user-initiated fluidic assay systems. Exemplary assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An exemplary... Agent: Garrett Ip, LLC C/o Cpa Global
20100015644 - Potency assays for antibody drug substance binding to an fc receptor: The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition comprising an antibody, specifically for use when applying for marketing authorization for said pharmaceutical composition. The assay provided is a method for determining the potency... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20100015649 - Biosensor: The present application provides apparatus (300, 400) and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator (108, 109, 110).... Agent: Moore & Van Allen PLLC
20100015650 - Kinase substrates: Tyrosine kinase substrates are described herein that are phosphorylated by many and diverse tyrosine kinases, and are chemically stable relative to co-polymers of poly-EY or poly-EAY having random molecular weights in the range of 20-50 kDa. Tyrosine kinase substrate peptides are provided according to embodiments described herein which include an... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.
20100015652 - Antibody quantitation: The invention relates to a novel method for determining the amount of an antibody of interest in a biological sample. In one embodiment, the method of the invention is characterized in that it comprises at least a step of protein depletion of said biological sample by pepsin digestion to produce... Agent: Novartis Institutes For Biomedical Research, Inc.
20100015651 - Predicting heart failure following myocardial infarction by protease and protease inhibitor profiling: Disclosed herein are methods of detecting or predicting diastolic heart failure in a subject, comprising identifying a profile of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) from a body fluid of the subject that is associated herein with the existence of likely development of left ventricular dilation... Agent: Patent Correspondence Arnall Golden Gregory LLP
20100015653 - Compounds regulating calreticulin, kdel receptor and/or erp-57 cell surface exposure and uses thereof to evaluate the efficiency of a cancer treatment: The present invention relates to a method for determining the susceptibility of a patient tumour cell to a cancer treatment, which method comprises the detection or measure of CRT, KDEL receptor and/or ERp57 on the surface of a tumour cell.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100015656 - Arrangement for on-line measurements on cells: The object of the invention, to specify an arrangement for on-line measurements in order to investigate and monitor the metabolism of living cells, which avoids the disadvantages of the prior art and can be integrated in a microfluidic system in the process, is achieved in that the arrangement comprises a... Agent: Jordan And Hamburg LLP
20100015658 - Meter strip and method for lateral flow assay devices: A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection region and a collection region. A blood sample meter is provided having a first end for absorption... Agent: Dority & Manning, P.A.
20100015657 - Methods and devices for assessing biological fluids: The present invention relates to devices, methods, and kits used to determine the source of an aliquot of a biological fluid, including the presence of additives in the biological sample.... Agent: Foley & Lardner LLP
20100015655 - Methods and kits for detecting and quantifying damage caused by a parasite: The present disclosure relates to assays and kits for detecting and quantifying damage caused by a parasite in a subject and monitoring the progression of parasitic disease in a subject.... Agent: Paul D. Yasger Abbott Laboratories
20100015654 - Negative regulation of nk cell functions by eat-2, a sap-related adaptor expressed in innate immune cells: The present invention relates to the identification EAT-2 and ERT as novel therapeutic targets for the modulation of innate immune cell functions. More particularly the present invention describes novel methods for modulating innate immune cells-mediated immune response, useful in the treatment of cancer, infectious diseases as well as autoimmune diseases.... Agent: Mcandrews Held & Malloy, Ltd
20100015659 - Pc5 as a factor ix propeptide processing enzyme: Compositions and methods for preparing Factor IX, Factor IX-containing fusion proteins, and Factor IX-containing conjugates with processing of Factor IX propeptide by PC5, are provided. In one embodiment PC5 is used to process a precursor polypeptide for a Factor IX-Fc monomer-dimer hybrid.... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.
20100015661 - Antibody-rnase-conjugate: The present invention provides a novel antibody-RNase conjugate which is a single chain protein, providing both the specificity of its antibody portion and the RNase activity of its RNase portion, resulting in an antigen specific effectiveness against cells when applied in vivo or in vitro, wherein the RNase portion is... Agent: Greer, Burns & Crain
20100015663 - Method for producing an antifungal peptide in a filamentous fungal host cell: The present invention provides a method for producing an antifungal peptide in a filamentous fungal host cell by expressing the antifungal peptide in a host cell which is deficient or partially deficient in the expression of an endogenous glucosyl-ceramide synthase (gcs) gene.... Agent: Novozymes North America, Inc.
20100015660 - Production of recombiant products using capillary membranes: The invention provides for a method of producing at least one recombinant product under aerated conditions. The method includes providing a porous substrate having a first side and a second side and which has a biofilm of microorganisms attached to the first side thereof, the substrate being configured to allow... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20100015662 - Use of cellobiohydrolase from phanerochaete: A cellobiohydrolase that can contribute to a synergistic effect on cellulose degradation and the use of such cellobiohydrolase in cellulose degradation are provided. The synergistic effect is achieved by an enzyme preparation for cellulose degradation containing a cellobiohydrolase originating in Phanerochaete chrysosporium and belonging to GHF6 or a variant thereof,... Agent: Oliff & Berridge, PLC
20100015665 - Antibodies and diagnostics: Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.... Agent: Marshall, Gerstein & Borun LLP
20100015666 - Isothermal dna amplification: The present invention provides for amplification of one or more polynucleotides by multi-staged linear amplifications using one or more RNA polymerases. At each stage RNA transcripts are accumulated at a linear rate, so that multiple stages provide for faster than linear transcript accumulation. In one aspect, the invention provides for... Agent: Bozicevic, Field & Francis LLP
20100015667 - Method of in vitro polynucleotide sequences shuffling by recursive circular dna molecules fragmentation and ligation: The present invention relates to a method for in vitro recombining polynucleotides sequences of interest from at least two initial different polynucleotide sequences of interest by cleavage/ligation of circular DNA molecules.... Agent: Ladas & Parry LLP
20100015668 - Programmable oligonucleotide synthesis: The invention relates to methods and devices for preparing synthetic nucleic acids.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100015669 - Method for constructing microrna adenovirus expression plasmids of severe hepatitis related hfgl2, hfas and htnfr1 genes and pharmaceutical use thereof: Provided is a method for constructing microRNA adenovirus expression plasmids comprising severe hepatitis related genes of hfgl2 (Human Fibrinogen-like protein 2) prothrombinase, Fas and TNFR1 (tumor necrosis factor receptor 1), and the specificity and effectivity of microRNA interference plasmids are detected at cellular level so that a combined use of... Agent: Matthias Scholl
20100015670 - Method of modifying nucleotide chain: A nucleotide chain to be modified, a nucleotide having a particular base that is different from bases constituting the nucleotide chain, an enzyme catalyzing addition of the nucleotide to the 3′-terminus of the nucleotide chain, a degrading enzyme acting specifically on the nucleotide, and a desired modifier for modifying the... Agent: Steptoe & Johnson LLP
20100015671 - Cyclic maltosylmaltose, cyclic maltosymaltose-forming enzyme, their preparation and uses: An object of the present invention is to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20100015672 - Gene expression cassette and a transformant, and a method for manufacturing 2-deoxy-scyllo-inosose and a method for purifying 2-deoxy-scyllo-inosose using said transformant: A transformant is prepared to insert at least a gene expression cassette comprising a gene involved in the synthesis of 2-deoxy-scyllo-inosose into E. coli as host cells. A 2-deoxy-scyllo-inosose is synthesized from D-glucose, oligosaccharide, polysaccharide, starch and rice bran, using the transformant. A culture solution containing the 2-deoxy-scyllo-inosose is treated... Agent: Buchanan, Ingersoll & Rooney PC
20100015674 - Methods for the preparation of lysine by fermentation of corynebacterium glutamicum: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of... Agent: Connolly Bove Lodge & Hutz, LLP
20100015673 - Microorganism of corynebacterium genus having enhanced l-lysine productivity and a method of producing l-lysine using the same: The present invention relates to a microorganism of Corynebacterium genus having enhanced L-lysine productivity and a method of producing L-lysine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus having enhanced L-lysine productivity by inactivating endogenous NCgl2534 gene having the amino acid sequence... Agent: Swanson & Bratschun, L.L.C.
20100015675 - Process for the production of fluorine containing alpha-hydroxy carboxylic acids: A process for the production of a fluorine containing α-hydroxy carboxylic acid by hydrolyzing a fluorine containing α-hydroxy nitrite in the presence of a nitrilase.... Agent: Solvay C/o B. Ortego - Iam-nafta
20100015676 - Method for producing polyesterols: (b) the mixture produced in (a) flows through a reactor in which at least one packing comprising at least one immobilized enzyme on a support is present, with the at least one base polyesterol and the at least one further reagent being reacted to form the polyesterol.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100015677 - Method and apparatus for production of bio-ethanol and other fermentation products: A method for converting organic material into hydrocarbon fuel, such as ethanol, the method comprising a fermentation process fermenting the organic material thereby providing a fermentation broth, a separation process separating the fermented material into a hydrocarbon fuel and a residual product, a conversion process at least partly converting the... Agent: Knobbe Martens Olson & Bear LLP
20100015678 - Thermophilic organisms for conversion of lignocellulosic biomass to ethanol: Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of Thermoanaerobacterium saccharolyticum with acetate kinase and phosphotransacetylase expression eliminated are disclosed herein. Further, strain ALK1 has been engineered by site directed homologous recombination to knockout both acetic acid and lactic acid production. Continuous culture... Agent: Lathrop & Gage LLP
20100015679 - Fermentation system having strainer assembly: A fermentation system for production of biogas from solid organic material, the system including at least one fermentation reactor. The fermentation reactor includes a vessel (37) for housing a feed mixture having liquid and solid particles and an outlet port (44), a strainer assembly (33) at the outlet port for... Agent: Morgan, Lewis & Bockius LLP (sf)
20100015680 - Process for the production of biogas: The invention relates to a process for the production of biogas from biomass, in particular from lignocellulose-containing biomass. According to the invention bio gas is produced from lignocellulose-containing biomass in a process, wherein the cellulose and hemicellulose in the lignocellulose are made accessible for bioconversion.... Agent: Lucas & Mercanti, LLP
20100015681 - Hydrogen production by means of a cell expression system: Expression vectors, host cells and methods of using a recombinant expression system for the production of hydrogen are disclosed. The expression vectors comprise the a bidirectional hydrogenase protein complex coding sequence of SEQ ID NO:1.... Agent: Alston & Bird LLP
20100015682 - Ultrasonic dissection device and ultrasonic dissection method: There is provided an ultrasonic dissection device for relatively removing a target biological object from other biological objects, the ultrasonic dissection device including an ultrasonic wave generation unit, an ultrasonic wave convergence unit, and a controller to control the ultrasonic wave generation unit.... Agent: Scully Scott Murphy & Presser, PC
20100015683 - Thermostable reverse transcriptases and uses thereof: The present invention is in the fields of molecular and cellular biology. The invention is generally related to reverse transcriptase enzymes and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to reverse transcriptase enzymes which have been mutated or modified to... Agent: Life Technologies Corporation C/o Intellevate
20100015684 - Factor vii: remodeling and glycoconjugation of factor vii: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.... Agent: Novo Nordisk, Inc. Intellectual Property Department
20100015685 - Lactobacillus n-deoxyribosyl transferases, corresponding nucleotide sequences and their uses: The invention concerns novel polypeptides and their fragments, isolated from Lactobacillus, having at least a N-deoxyribosyl transferase activity, the polynucleotides encoding said polypeptides, cloning and/or expression vectors including said polynucleotides, cells transformed by said vectors and specific antibodies directed against said polypeptides. The invention also concerns a method for enzymatic... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100015686 - Variant alpha-amylases from bacillus subtilis and methods of uses, thereof: Alpha-amylases from Bacillus subtilis (AmyE), variants thereof, nucleic acids encoding the same, and host cells comprising the nucleic acids are provided. Methods of using AmyE or variants thereof are disclosed, including liquefaction and/or saccharification of starch. Such methods may yield sugars useful for ethanol production or high fructose corn syrup... Agent: Danisco US Inc. Attention: Legal Department
20100015687 - Tetracycline repressor regulated oncolytic viruses: The present invention is directed oncolytic Herpes simplex-1 viruses whose replication is controlled using a tetracycline operator/repressor system. The invention also includes DNA sequences used in making the viruses and methods in which these viruses are used in the treatment of cancer patients with solid tumors.... Agent: Law Office Of Michael A. Sanzo, LLC
20100015688 - Novel microorganism capable of degrading diphenylarsinic acid: Disclosed are: a microorganism capable of degrading diphenylarsinic acid; a method for degrading diphenylarsinic acid by using the microorganism; a method for clean-up of a contaminated soil by using the microorganism; an agent for degrading diphenylarsinic acid, which comprises the microorganism; and a cleaning agent for a contaminated soil or... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20100015689 - Method for composting and treating food waste by using wood chips and apparatus therefor: The present invention relates to a method of composting and treating food waste by using wood chips and an apparatus therefor. The method and apparatus for the composting and treatment of food waste in accordance with the present invention can recycle food waste as an organic compost by using wood... Agent: Jones Day
20100015690 - Use of fluid aspiration/dispensing tip as a microcentrifuge tube: A fluid aspirating/dispensing member includes a sample cavity for sample acquisition and a sealable cavity that, once sealed, permits the separation of particles from the remainder of a fluid sample within the sample cavity after centrifugation or other separation means. The fluid aspirating/dispensing members, either individually or as part of... Agent: Hiscock & Barclay, LLP
20100015691 - Apparatus for hemolyzing a blood sample and for measuring at least one parameter thereof: An apparatus for hemolyzing a blood sample and for measuring at least one parameter thereof comprises a sample chamber for accommodation of the blood sample, the sample chamber having a first sidewall and an opposite second sidewall. The apparatus also comprises ultrasonic generator for generating ultrasonic waves in the first... Agent: Morgan Lewis & Bockius LLP
20100015692 - Small volume in vitro sensor and methods of making: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or... Agent: Abbott Diabetes Care Inc. Bozicevic, Field & Francis LLP
20100015693 - Composting cage: Offloading apparatus (30) for a composting cage comprising an enclosure (10), which maybe divided into a plurality of compartments, for receipt of material to be composted is mounted below the enclosure (10) and is capable of travelling there below in order to extract compost from the base of the enclosure.... Agent: Speckman Law Group PLLC
20100015694 - Filtered petri dish: A petri dish includes a cover and base, the cover having at least one circular opening in the top of the cover. A number of securing members are connected to the underside of the cover around the opening to secure at least one filter under the opening, the filter(s) being... Agent: Jones Day
20100015695 - Method and apparatus for amplifying nucleic acids: A method and apparatus for amplifying nucleic acids. The method includes introducing into a reaction vessel via different inlet channels a reactant aqueous solution containing reactants for nucleic acid amplification and a fluid that is phase-separated from the reactant aqueous solution and does not participate in amplification reaction, creating a... Agent: Cantor Colburn, LLP
20100015696 - Disposable bioreactor: A disposable material processing apparatus, useable as a bioreactor or fermenter, includes a hollow tank (101) and a mixing paddle (110) disposed within the interior of the tank and adapted to mix contents therein. The paddle may be isolated within a flexible sleeve (140). Various functional elements, such as a... Agent: Intellectual Property / Technology Law
20100015697 - Micro-fluidic cell manipulation and holding device: A micro-fluidic manipulation device is formed using a plastic material or glass. There is at least one well in the device. The well has a base and a side wall and is dimensioned to receive a cell. There is at least one base fluid port in the base of the... Agent: Brinks Hofer Gilson & Lione/chicago/cook
20100015698 - Human chondroitinase glycoprotein (chasegp), process for preparing the same, and pharmaceutical compositions comprising thereof: The invention relates to the discovery of novel Chondroitinase Glycoproteins (CHASEGPs), methods of manufacture, and potential uses in conditions where removal of chondroitin sulfates may be of therapeutic benefit. Chondroitinase Glycoproteins require both a substantial portion of the catalytic domain of the CHASEGP polypeptide and asparagine-linked glycosylation for optimal chondroitinase... Agent: Dla Piper LLP (us)
20100015700 - Use of the adenoviral e2 late promoter: The invention relates to a nucleic acid construct comprising an adenoviral E2 late promoter or a fragment thereof and a nucleic acid. The nucleic acid is selected from the group of transgenes, genes and nucleic acids which are respectively different from adenoviral nucleic acid controlled by an E2 late promoter.... Agent: Polsinelli Shughart PC
20100015699 - Vectors and methods for tissue specific synthesis of protein in eggs of transgenic hens: Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to an embryonic chicken cell, so as to create a transgenic hen wherein the transgene is expressed in the hen's oviduct... Agent: Wilmerhale/boston
20100015702 - Generation, characterization and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor: Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not... Agent: Jane Massey Licata, Esq.
20100015701 - Novel fluorescent proteins and methods for using same: The present invention provides nucleic acid molecules encoding novel red fluorescent proteins from Entacmaea quadricolor and mutants thereof. Also of interest are proteins that are substantially similar to the novel red fluorescent proteins. In addition, host cells, stable cell lines and transgenic organisms comprising the nucleic acid molecules encoding the... Agent: Patterson & Sheridan, L.L.P.
20100015703 - Antibody to mammalian cytokine-like polypeptide-10: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.... Agent: Darby/zymogenetics, Inc.
20100015704 - Process for the enrichment of melanocytes by means of modified surfaces: The present invention relates to processes for obtaining melanocytes from a cell suspension, in particular from an epidermal cell suspension, by means of a culture vessel, wherein at least a part of the surface of the culture vessel facing the culture space, is modified, in particular functionalized, in particular by... Agent: Harness, Dickey & Pierce, P.L.C
20100015705 - Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions: Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.... Agent: Quarles & Brady LLP
20100015706 - Nucleic acid compounds for inhibiting hif1a gene expression and uses thereof: The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing HIF1A gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.
20100015708 - Ribonucleic acids with non-standard bases and uses thereof: The present disclosure provides a ribonucleic acid comprising a double-stranded region having at least one base pair comprising a 5-methyluridine base paired with a 2,6-diaminopurine and methods for preparing the same. Also provided are methods for treating or preventing a disease or disorder by inducing RNAi.... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.
20100015707 - Short interfering ribonucleic acid (sirna) for oral administration: Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification.... Agent: Novartis Institutes For Biomedical Research, Inc.
20100015711 - Differentiation of pluripotent stem cells: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount... Agent: Philip S. Johnson Johnson & Johnson
20100015710 - Methods and compositions for isolating, maintaining and serially expanding human mesenchymal stem cells: Compositions and methods for isolating and expanding human mesenchymal stem/progenitor cells through multiple passages in defined serum-free environments are provided. The culture media compositions includes a basal medium supplemented with a nutrient mixture such as Ham's F12 nutrient mixture, glutamine, buffer solutions such as sodium bicarbonate and hepes, serum albumin,... Agent: Fulbright & Jaworski L.L.P.
20100015709 - Regulating stem cell differentiation by controlling 2d and 3d matrix elasticity: Provided are methods for the selection and regulation of the mechanical properties of 2D or 3D biocompatible substrates or tissue microenvironments as a technique to regulate in vitro differentiation, cell shape and/or lineage commitment of anchorage-dependent cells, such as mesenchymal stem cells into, e.g., neurogenic-, myogenic-, and osteogenic-type cells. Substrate... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20100015712 - Side population cells originated from human amnion and their uses: Cells which may be differentiated at least into nerve cells, which are useful for therapies of brain metabolic diseases, are disclosed. The cells are side population cell separated from human amniotic mesenchymal cell layer, in which expressions of Oct-4 gene, Sox-2 gene and Rex-1 gene are observed by RT-PCR, and... Agent: Birch Stewart Kolasch & Birch
20100015713 - Components of cell culture media produced from plant cells: The present invention comprises the production of components of cell culture media produced from plant cells and cell culture media containing the same. Heterologous DNA comprising genes encoding the desired component are introduced into plant cells, especially rice, which then produce the desired component. The component can be isolated from... Agent: Arent Fox LLP01/14/2010 > patent applications in patent subcategories. recently filed with US Patent Office
20100009334 - Method for treatment and storage of platelets: Provides are improved methods for storing platelets and compositions that contain stored platelets for use in transfusions. The method entails obtaining a platelet concentrate from blood obtained from an individual and holding the platelet concentrate in at refrigerated temperatures under an atmosphere having a pressure of from 3.5 to 5... Agent: Hodgson Russ LLP The Guaranty Building
20100009333 - Methods for acoustic particle focusing in biological sample analyzers: Methods for using acoustic focusing technology on its own or in conjunction with hydrodynamic focusing for analyzing biological samples are provided. In one application, a preferential orientation of biological particles is achieved by applying a substantially elliptical acoustic field. In another application, a sample comprising a fluid medium carrying a... Agent: Beckman Coulter, Inc. Mitchell E. Alter
20100009336 - System and method for bacterial vaginosis testing: A method and system for testing fluids from a patient is provided. In one embodiment, a portable device is configured with one or more testing modules adapted perform one or more tests on a fluid sample in order to determine if a patient has bacterial vaginosis. A timer module coupled... Agent: C. Bart Sullivan
20100009335 - Temperature-regulated culture plates: Described herein are environmentally isolated tissue culture devices that may be used for cell culture, as well as systems including these devices and methods for using them. These devices may include control features for regulating the micro-environment within a well or wells of the device. For example, on-board features may... Agent: Morrison & Foerster LLP
20100009337 - Novel genes related to glutaminyl cyclase: Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 18.104.22.168), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl... Agent: Sonnenschein Nath & Rosenthal LLP
20100009343 - Compositions and method for rapid, real-time detection of influenza a virus (h1n1) swine 2009: Disclosed are oligonucleotide amplification primers and detection probes specific for the amplification and detection of pathogenic organisms, including for example, specific Influenza A H1N1 viral isolates. Also disclosed is a biological organism identification kit including the disclosed nucleic acid probes and primers, as well as thermal cycling reagents that is... Agent: Haynes And Boone, LLPIPSection
20100009340 - Compositions and methods for the analysis and treatment of aids wasting syndrome and immune cell dysfunction: The present invention relates to aberrant cell signaling by the HIV type I envelope glycoprotein. In particular, the present invention provides compositions and methods for identification of inhibitors of melanocortin receptor pathway stimulation by HIV-I gp120 and its degradation products. The inhibitors so identified are contemplated to be suitable for... Agent: Morrison & Foerster LLP
20100009342 - Control of chemical modification: Provided is a method for controlling the degree of labeling (DOL) of a carrier molecule or solid support by the addition of a reactive label competitor to the labeling reaction. When the reactive label competitor is added to the labeling solution the competitor competes with the carrier molecule or solid... Agent: Life Technologies Corporation C/o Intellevate
20100009339 - Detection method for influenza viruses: o
20100009344 - Liquid crystal based analyte detection: The present invention relates to the field of detection of viruses, and in particular to detection of viruses using a liquid crystal assay format. In the present invention, virus binding in a detection region is identified by changes in liquid crystal orientation caused by virus binding independent orientation caused by... Agent: Casimir Jones, S.c.
20100009341 - Methods and means for assessing hiv gag/protease inhibitor therapy: The present invention relates to methods and means for the evaluation of HIV treatment. In particular, molecular events at the HIV gag and protease proteins and their effect on therapeutic efficacy of drugs are determined The methods rely on providing HIV gag and protease nucleic acid material and evaluating a... Agent: Philip S. Johnson Johnson & Johnson
20100009338 - Novel gold nanostructures and methods of use: The invention is drawn to novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors, conduits for fluids, and electronic conductors. The nanostructures can be used in microfluidic devices, for transporting fluids between devices and structures in analytical devices, for conducting electrical currents between devices and structure in... Agent: Bell & Associates
20100009345 - Compositions and methods comprising a ligand of chemerin r: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related... Agent: Edwards Angell Palmer & Dodge LLP
20100009361 - Compositions and methods for detecting noonan syndrome: Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in a RAS-specific guanine nucleotide exchange factor gene SOS1 or its expression product. The diagnostic and therapeutic applications are also based on certain mutations in a serine/threonine protein kinase gene RAF1... Agent: Darby & Darby P.C.
20100009358 - Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers. A variety of newly identified markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of breast cancer.... Agent: Mccarter & English, LLP Boston
20100009356 - Diagnosis of cardiovascular disease: This invention relates to methods for the detection of cardiovascular disease, e.g., acute coronary syndrome, heart failure and/or pulmonary embolism, in high body mass index (BMI) individuals, e.g., with a BMI of 25-29, or 30 or above, and those with impaired renal function.... Agent: Fish & Richardson PC
20100009353 - Dye compounds and the use of their labelled conjugates: Novel rhodamine dye compounds, labelled conjugates comprising the dyes are described, together with methods for their use. The dyes and labelled conjugates are useful as molecular probes in a variety of applications, such as in assays involving staining of cells, protein binding, and analysis of nucleic acids, such as hybridization... Agent: Klauber & Jackson
20100009362 - Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same: The presently described subject matter is directed to water-soluble conjugated polyene compounds that exhibit aggregation induced emission, as well as to water dispersible, fluorescent, polymeric microparticles and/or nanoparticles comprising the water-soluble conjugated polyene compounds. Also provided are methods of making and using the compounds and particles. The described conjugated polyene... Agent: The Nath Law Group
20100009370 - Gene assaying method, gene assaying program, and gene assaying device: A gene assaying method includes the steps of: acquiring two or more data which should be compared and represents expression levels of a plurality of target genes; converting the expression levels represented by the acquired two or more data into ratios based on the expression level of one of the... Agent: Sonnenschein Nath & Rosenthal LLP
20100009369 - Gene expression level analyzing method, gene expression level analyzing program, and gene expression level analyzing device: A gene expression level analyzing method includes the steps of: acquiring expression levels of a plurality of target genes in a target cell every measurement time; extracting a maximum expression level and a minimum expression level from the expression levels of the target genes every measurement time; calculating a correlation... Agent: Sonnenschein Nath & Rosenthal LLP
20100009347 - Kit and method for detecting urothelial cancer: This invention relates to a method for detecting in vitro a urothelial cancer, comprising measuring CXCL1 protein, or expression of a gene encoding the protein, in a biological sample from a subject, and to a kit for diagnosing a urothelial cancer comprising an antibody or nucleic acid probe, which is... Agent: Birch Stewart Kolasch & Birch
20100009346 - Lafora's disease gene: A novel gene (EPMZA) that is deleted or mutated in people with Lafora's disease is described. The EPM2A gene encodes a protein having an active catalytic site of a protein tyrosine phosphatase. Many different sequence mutations as well as several microdeletions in EMP2A have been found that co-segregate with Lafora's... Agent: Foley And Lardner LLP Suite 500
20100009354 - Method for determining base sequence of dna: The present invention provides a method for determining the base sequence of a DNA. According to the method for determining the base sequence of a DNA of the present invention, a probe is used, which is a probe having a protruding end and identification-labeled according to the species of the... Agent: Foley And Lardner LLP Suite 500
20100009372 - Method for estimating target nucleic acid ratio: The inventive method is a method for estimating a target nucleic acid ratio, which includes (a) preparing a standard nucleic acid sample series having different mixing ratios of a target nucleic acid to the total amount of target nucleic acid and reference nucleic acid; (b) performing PCR on each of... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20100009376 - Method for measuring dna methylation: The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on.... Agent: Panitch Schwarze Belisario & Nadel LLP
20100009352 - Method for modeling a disease: The invention described herein provides for methods of profiling cellular models of disease. Cellular systems biology is the investigation of the integrated and interacting networks of genes, proteins, and metabolites that are responsible for normal and abnormal cell functions. Methods and reagents for the profiling a disease state, the treatment... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20100009350 - Method for quantitative analysis of transcripts with nucleotide polymorphism at specific site: The present invention provides a quantitative method for assaying the expression ratio between alleles differed by a single nucleotide polymorphism.... Agent: Wpat, PC Intellectual Property Attorneys
20100009360 - Method for the detection of egfr mutations in blood samples: The present invention refers to the detection of EGFR mutations in a blood (serum/plasma) sample from a subject. The method comprises: (i) obtaining the DNA from said sample; (ii) amplifying the nucleic acid sequence corresponding to a specific region of the EGFR gene by means of PCR using a Protein-Nucleic... Agent: Intellectual Property / Technology Law
20100009349 - Method for treating a biological sample: The invention relates to a method for treating a biological sample, comprising the following method steps: i) preparation of a biological sample and ii) bringing the biological sample into contact with a composition, comprising: (1) 1 to 100 wt. % of at least one polyol and (2) 0 to 99... Agent: Leon R. Yankwich Yankwich & Associates
20100009359 - Methods and compositions for detecting colon cancers: This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.... Agent: Ropes & Gray LLP
20100009377 - Methods and compositions for diagnosing and monitoring auto immune and chronic inflammatory diseases: Methods of diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis... Agent: Morrison & Foerster LLP
20100009368 - Methods and compositions for the assessment of cardiovascular function and disorders: The present invention provides methods for the assessment of risk of developing acute coronary syndrome (ACS), arterial inflammation, or ACS-associated impaired vascular function, in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing... Agent: Davis Wright Tremaine LLP - San Francisco
20100009373 - Methods and compositions relating to multiplex genomic gain and loss assays: Compositions and methods are provided for detecting genomic DNA gain and loss. Embodiments of inventive compositions and methods include composite nucleic acid probes which specifically hybridize to two or more genomic loci in a genomic region of a reference genome for detection of genomic gain and/or loss in a subject... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.
20100009348 - Methods and constructs for analyzing biological activities of biological specimens and determining states of organism: This application provides methods of determining biological activities of a biological sample comprising, for example, comparing the profile of transcription factor activities in a cell contacted with the biological sample to a control profile, such as a profile of transcription factor activities in a cell not contacted with the biological... Agent: Jones Day
20100009364 - Methods for diagnosis, prognosis and methods of treatment: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that... Agent: Wilson, Sonsini, Goodrich & Rosati / Nodality, Inc
20100009367 - Micro rnas and their methods of use for the treatment and diagnosis of schizophrenia and schizophrenia spectrum disorders: A method of diagnosing, assessing susceptibility, and/or treating schizophrenia involving the identification and/or observation of microRNAs (miRNA) and variant miRNA are provided. Micro RNAs alleles associated with schizophrenia and schizophrenia spectrum disorders were identified and ultra-rare variants in the precursor or mature miRNA were identified. Functional analyses of ectopically expressed... Agent: Perkins Coie LLP
20100009366 - Polymorphisms in the human genes for oct1 and their use in diagnostic and therapeutic applications: The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or... Agent: Ropes & Gray LLP
20100009351 - Polynucleotide capture materials, and method of using same: Methods for processing polynucleotide-containing biological samples, and materials for capturing polynucleotide molecules such as DNA from such samples. The DNA is captured by polyethyeleneimine (PEI) bound to a surface, such as the surface of magnetic particles. The methods and materials have high efficiency of binding DNA and of release, and... Agent: Fish & Richardson P.C.
20100009357 - Prediction of lung cancer tumor recurrence: The invention provides methods of estimating the likelihood of lung cancer recurrence in a subject, including those afflicted with NSCLC. The methods of the invention are useful for developing a therapeutic treatment plan to prevent cancer recurrence for subjects deemed to be at high risk, and withholding treatments from those... Agent: Michael Best & Friedrich LLP
20100009365 - Process for high-throughput dna methylation analysis: There is disclosed an improved high-throughput and quantitative process for determining methylation patterns in genomic DNA samples based on amplifying modified nucleic acid, and detecting methylated nucleic acid based on amplification-dependent displacement of specifically annealed hybridization probes. Specifically, the inventive process provides for treating genomic DNA samples with sodium bisulfite... Agent: Davis Wright Tremaine, LLP/seattle
20100009363 - Rbp4 in insulin sensitivity/resistance, diabetes, and obesity: Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20100009371 - Selection of markers: t
20100009355 - Selective amplification of minority mutations using primer blocking high-affinity oligonucleotides: In certain embodiments this invention pertains to methods of detecting and/or quantifying rare mutant nucleic acids in populations of nucleic acids in which the wild-type nucleic acids are in substantially greater abundance than the rare mutants. In various embodiments the methods utilize short high affinity oligonucleotides targeted to the wild... Agent: Weaver Austin Villeneuve & Sampson LLP
20100009375 - Silica magnetic particles with a high nucleic acid binding capacity: Magnetic particles for nucleic acid isolation are coated with silica and separated from impurities and nanoparticulates using a multi-step fractionation process. In each cycle of the fractionation process, the particles are stirred, sedimented, and resuspended, resulting in a decline in pH of the suspended particles. Repeating the fractionation process until... Agent: Siemens Corporation Intellectual Property Department
20100009374 - Sire early selection for male fertility using single nucleotide polymorphisms (snps) of the dazl gene: Methods and materials for identifying bovine males which will produce semen which will exhibit a higher rate of successfully impregnation by either artificial insemination or natural mating. The method employs SNPs that have been identified in the bDAZL gene which are associated with enhanced (or decreased) male fertility in bovine... Agent: Unr/dri Technology Transfer Office
20100009380 - Compositions and methods for characterization of cysteine oxidative states: The present invention relates to compositions and methods for characterization of cysteine oxidative states. In particular, the present invention provides cysteine-oxidative-state-specific labeling agents and uses thereof.... Agent: Casimir Jones, S.c.
20100009381 - Compositions and methods for detection and isolation of phosphorylated molecules: The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and... Agent: Life Technologies Corporation C/o Intellevate
20100009378 - Mass spectrometric methods and products: The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.... Agent: Wolf Greenfield & Sacks, P.C.
20100009382 - Methods and compositions for diagnosing lung cancer: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ubiquilin 1 markers for cancer.... Agent: Casimir Jones, S.c.
20100009379 - Nanoparticle-textured surfaces and related methods for selective adhesion, sensing and separation: Textured heterogeneous surfaces and related articles as can be used in conjunction with methods for selective sensing and/or separation.... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator
20100009384 - Actr-1, a novel human acyltransferase and uses thereof: The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which... Agent: Millennium Pharmaceuticals, Inc.
20100009385 - Assays and enhancers of the human delta enac sodium channel: This invention relates to electrophysiological assays that measure sodium conductance activity of a delta human epithelial sodium channel (ENaC) in the presence and absence of delta hENaC enhancers. Also, the invention generally relates to assays for identifying compounds that enhance the activity of delta hENaC, especially in an oocyte expression... Agent: Hunton & Williams LLP Intellectual Property Department
20100009387 - Detection of early stages and late stages hpv infection: Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by various HPV genotypes, early and/or late stage HPV-associated or HPV-specific cancers. Various specific or pan monoclonal antibodies recognizing specific epitope for specific HPV protein or... Agent: Shuling Cheng
20100009383 - Method for the simple and rapid detection of cells and biomolecules by means of paramagnetic particles: The invention relates to a simple and rapid method for the detection of cells and biomolecules by means of paramagnetic particles (beads) without separating the detected biomolecules or target cells from the beads before evaluating the specific bond.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20100009386 - Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof: The invention provides biomarkers and combinations of biomarkers that are useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on... Agent: Hunton & Williams LLP Intellectual Property Department
20100009390 - Mutant antibodies with high affinity for egfr: This invention provides antibodies that have improved affinity for the epidermal growth factor receptor (EGFR). In addition, this invention provides microparticles and nanoparticles comprising a plurality of EGFR affinity moieties that are effectively internalized by cells expressing an EGFR.... Agent: Weaver Austin Villeneuve & Sampson LLP
20100009388 - Differential detection of multimeric and monomeric forms of multimer-forming polypeptides: A method for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide in a biosample includes (a) contacting the biosample to a capturing antibody recognizing an epitope on the multimer-forming polypeptide to capture the monomeric form, multimeric form or monomeric and multimeric forms; (b) contacting the... Agent: The Rafferty Patent Law Firm
20100009389 - Method of making and using versatile positive controls and antibody detection assays: The present invention is in the technical field of ligand-binding assays for detection of antigen-specific antibodies. Specifically a method for preparation of a versatile positive control, components of which can be mixed and matched in numerous combinations to render positive controls for antigen specific antibodies of a wide variety of... Agent: PCt Law Group, PLLC
20100009393 - Factor h polymorphisms in the diagnosis and therapy of inflammatory diseases such as age-related macular degeneration: The invention relates to antibodies, including monoclonal and polyclonal, or fragments thereof, which discriminate between the histidine and tyrosine isoforms of Complement Factor H and to their use in diagnostic methods and therapeutic treatments relating to Complement Factor H mediated diseases.... Agent: King & Schickli, PLLC
20100009391 - Method for extracting gluten from processed and unprocessed foods by means of heat based on the use of ionic and non-ionic detergents: The present invention relates the analysis of foods for celiac patients. In particular, the invention includes: a method for extracting gluten from foods, which is compatible with an enzyme-linked immunosorbent assay (ELISA) and with the Western Blot technique; compositions suitable for implementing this method; kits that comprise these compositions; a... Agent: Darby & Darby P.C.
20100009392 - Use of melanoma inhibitory activity (mia) protein as an early indicator for therapeutic response in melanoma: The present invention provides a method for determining a response of a mammalian subject having melanoma tumor cells to treatment with a melanoma inhibitory agent. In one aspect, the method comprises (a) determining a first concentration of melanoma inhibitory activity protein (MIA) in a first biological sample taken from the... Agent: Novartis Corporate Intellectual Property
20100009394 - Universal tandem solid-phases based immunoassay: Universal tandem solid-phases based immunoassay (UTSIA) is a sandwich-ELISA equivalent assay for low abundance antigen determination that overcomes limitations of sandwich-ELISA (antibody inactivation by solid phase and strict requirement of a pair of primary and secondary antibodies) by using an affinity binding solid phase to capture antigen specifically from a... Agent: Ribo Guo
20100009395 - Luminescence assay utilizing a genetically modified cell line: An assay method to identify agents that will reduce the inflammation associated with many diseases, providing a method to determine compliance of patients to clinical protocols. The fundamental tool of the inventive method is luminescence. Genetically modified cells are used to express a complex revealing the potential of certain compounds... Agent: Quarles & Brady LLP
20100009397 - Substrate-mimetic akt inhibitor: Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue were characterized. Functionally homologous non-peptide groups were substituted for the amino acids of the GSK-3 creating a hybrid peptide-non-peptide... Agent: Smith Hopen, Pa
20100009398 - Biological reaction apparatus with draining mechanism: A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region, wherein the apparatus includes a locating means to locate the substrate; a... Agent: Sughrue Mion, PLLC
20100009402 - Method of evaluating breast cancer, breast cancer-evaluating apparatus, breast cancer-evaluating method, breast cancer-evaluating system, breast cancer-evaluating program and recording medium: According to the method of evaluating breast cancer of the present invention, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and a breast cancer state in the subject is evaluated based on the concentration value of... Agent: Foley And Lardner LLP Suite 500
20100009401 - Method of evaluating colorectal cancer, colorectal cancer-evaluating apparatus, colorectal cancer-evaluating method, colorectal cancer-evaluating system, colorectal cancer-evaluating program and recording medium: According to the method of evaluating colorectal cancer of the present invention, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and a colorectal cancer state in the subject is evaluated based on the concentration value of... Agent: Foley And Lardner LLP Suite 500
20100009400 - Methods of studying a biomarker, and methods of detecting a biomarker: Embodiments of the present disclosure provide for methods of studying (e.g., detecting, localizing, and/or quantifying) biomarker(s) and the like.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP
20100009399 - Novel population of multipotent cardiac precursor cells derived from human blastocysts derived stem cells: Furthermore, the MCP cells have a characteristic morphology. They grow as clusters of small, round and phase-bright cells; individual cells are 5-20 μm in diameter and each cluster is composed of 2-500 cells. They form clusters of round or elongated shape, that appear as loosely adherent cell clumps that as... Agent: Buchanan, Ingersoll & Rooney PC
20100009403 - Reduced activity of ubica in e. coli: Production of products by engineered bacteria is increased by regulating cellular respiration. Cellular respiration is controlled by reducing electron transfer enzyme activity. Some examples of electron transfer enzymes include NADH dehydrogenases, Succinate dehydrogenases, ubiquinone synthesis, cytochrome O, and cytochrome D. In one example, deletion of UbiCA prevents respiration. Respiration can... Agent: Baker & Mckenzie LLP
20100009404 - Production of beta-lactam antibiotics: The present invention describes a process for the production of an N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl β-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cysteinyl-valine (HpgCV) or phenylglycyl-cysteinyl-valine (PgCV), respectively, to the N-hydroxyphenylglycyl or the N-phenylglycyl β-lactam antibiotic, respectively. The tripeptide HpgCV or the tripeptide PgCV may further be... Agent: Nixon & Vanderhye, PC
20100009405 - Biosynthetic process for the preparation of gallidermin: A process for the production of gallidermin comprises fermentative production of the respective biologically in-active and non-toxic pre-form(s) by either genetically engineered producer organism or mutants of the natural producer organism that are deficient for the extracelluar gallidermin pathway specific serine-pro tease. The process includes a downstream process in which... Agent: Jacobson Holman PLLC
20100009406 - Nucleic acids encoding a heme binding protein polypeptide: The present invention relates to methods, reagents and kits for detecting of formyl peptide receptor like-2 (FPRL2) polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against FPRL2. It further relates to substances for preventing, treating and/or alleviating diseases or disorders... Agent: Edwards Angell Palmer & Dodge LLP
20100009407 - Processing enzymes fused to basic protein tags: The invention is related to processing enzyme comprising an N-terminally attached tag derived from highly basic proteins from thermophilic bacteria. The processing enzymes are useful for modifying proteins. They can be produced in high yields and can be effectively separated from the modified protein after use.... Agent: Novo Nordisk, Inc. Intellectual Property Department
20100009408 - Induction of gene expression using a high concentration sugar mixture: Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for the compositions preparation and use.... Agent: Victoria L. Boyd Genencor International, Inc.
20100009410 - Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing: The invention provides a method of producing multiple polypeptides, such as antibodies or antibody fragments, in a eukaryotic cell using a single expression vector. The expression vector is engineered to comprise two or more expression cassettes under the control of a single promoter wherein the expression cassettes have splice sites... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20100009409 - Molecular variant fibrinogen fusion proteins: Fibrinogen fusion proteins, methods of making, and methods of using fibrinogen fusion proteins are described. In a preferred embodiment the fibrinogen fusion protein contains a truncated Aα chain of fibrinogen. The Aα chain contains truncation site, which is a deletion of amino acids at its C-terminal region. A non-fibrinogen protein... Agent: Pabst Patent Group LLP
20100009411 - Method and kits for repairing nucleic acid sequences: Methods and kits for DNA repair are provided. The methods and kits described herein repair multiple types of DNA damage. The kit may include a plurality of enzymes to repair a greater variety of lesions than any single enzyme is capable of repairing. Repair of damaged DNA may include releasing... Agent: General Electric Company (pcpi) C/o Fletcher Yoder
20100009412 - Novel oligonucleotide primers and methods for dna replication: The present invention relates to methods and oligonucleotide primers for initiating polymerase-catalyzed DNA synthesis at a target region on a polynucleotide template, using an oligonucleotide primer comprising (i) a 5′ universal sequence or extension sequence; (ii) a 3′ target-specific primer sequence corresponding to a target region on the polynucleotide template;... Agent: Siemens Corporation Intellectual Property Department
20100009413 - Nucleic acid molecules encoding alternansucrase: Nucleic acid molecules encoding an alternansucrase are provided. Moreover, vectors, host cells and plant cells transformed by the herein-described nucleic acid molecules and plants containing them are provided. Furthermore, methods are described for preparing transgenic plants which synthesize the carbohydrate alternan, because of the insertion of nucleic acid molecules encoding... Agent: Birch Stewart Kolasch & Birch
20100009414 - Polysaccharide transferase: The present invention is predicated on the discovery that a polysaccharide transferase purified from barley seedlings can catalyze the formation of covalent bonds between different polysaccharides, including between xyloglucans and cellulose, and between xyloglucans and (1,3;1,4)-β-D-glucans. The present invention thus provides, among other things, an isolated or substantially purified polysaccharide... Agent: Mckee, Voorhees & Sease, P.L.C
20100009415 - L-amino acid amide asymmetric hydrolase and dna encoding the same: A recombinant microorganism is produced by introducing a DNA encoding an enzyme which hydrolyzes an amido bond of L-amino acid amide, especially L-2-alkylcysteine amide, and L-amino acid is produced by using cells or cell processed product of the obtained microorganism.... Agent: Knobbe Martens Olson & Bear LLP
20100009416 - Process for the preparation of l-methionine: The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased.... Agent: Smith, Gambrell & Russell
20100009417 - Chemoenzymatic process for the preparation of iminocyclitols: The present invention discloses a chemoenzymatic process for the preparation of an iminocyclitol corresponding to formula (I), (II), (III) or (IV), wherein: R1 and R2 are the same or different, and independently selected from the group consisting of: H, OH, hydroxymethyl, methyl, ethyl, butyl, pentyl, hexyl, octyl, isopropyl, isobutyl, 2-methylbutyl,... Agent: Berenbaum Weinshienk PC
20100009418 - Increasing nadph-dependent products: A method of increasing cellular NADPH levels by expressing one or more genes that encode an enzyme that causes the production of NADPH. The system is combined with other enzymes that require NADPH, thus improving the overall yield of the desired product.... Agent: Baker & Mckenzie LLP
20100009419 - Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate: A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enzyme. The one or more gene disruptions confers increased production of acrylate onto... Agent: Mcdermott, Will & Emery
20100009420 - Genetic modification of homolactic thermophilic bacilli: The present invention relates to genetic modification for industrial applications of moderately thermophilic Bacillus species that are facultative anaerobic and homolactic. The present invention comprises a method for modifying moderately thermophilic Bacillus species that are facultative anaerobic and homolactic by genetic engineering comprising: introducing a DNA cloned in a thermosensitive... Agent: Oliff & Berridge, PLC
20100009421 - Method for the enzymatic reduction of alkyne derivates: e
20100009422 - Ethanol preparation method: Provided is a method for preparing ethanol in high efficiency. The ethanol preparation method includes a step of yielding a saccharide water solution through saccharification of cellulose with an enzyme in water, a step of condensing the saccharide water solution, and a step of yielding an ethanol water solution by... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20100009423 - B. braunii, race b gene for a triterpene methyltransferase enzyme and uses thereof: Provided is an isolated polypeptide having triterpene methyltransferase activity. Also provided is an isolated nucleic acid molecule that encodes the triterpene methyltransferase polypeptides; a vector comprising the nucleic acid molecules that encode the triterpene methyltransferase polypeptides; and a host cell(s) transfected with the aforementioned nucleic acid molecule or vector. In... Agent: Crowell & Moring LLP Intellectual Property Group
20100009424 - Sonoporation systems and methods: The present invention is directed to devices and methods that apply ultrasonic energy for the purpose of inducing transfection and cell transformation. A sonoporation system in accordance with embodiments of the present invention includes an ultrasonic electrical energy generator connected to an ultrasonic transducer producing stress waves. The ultrasonic transducer... Agent: Jeffrey J. Vaitekunas
20100009425 - Glycoprotein synthesis: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a... Agent: Quine Intellectual Property Law Group, P.C.
20100009426 - Nitrilases, nucleic acids encoding them and methods for making and using them: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.... Agent: Verenium Corporation Intellectual Property Department
20100009427 - Synthesis of fluorescent metal nanoclusters: Fluorescent metal nanoclusters were prepared.... Agent: Los Alamos National Security, LLC
20100009428 - Container, frozen material packaging body, and method of manufacturing packaging body: A frozen culture packaged body configured so that it does not deform or burst even if the content and gas in the container inflate due to a temperature difference between before and after forming a frozen culture within the body, wherein the frozen culture packaged body is capable of performing... Agent: Ladas & Parry LLP
20100009429 - In situ heat induced antigen recovery and staining apparatus and method: An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do... Agent: Dunlap Codding, P.C.
20100009430 - Analytical cartridge with fluid flow control: Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without... Agent: Quine Intellectual Property Law Group, P.C.
20100009431 - Cartridge containing reagent, microfluidic device including the cartridge, method of manufacturing the microfluidic device, and biochemical analysis method using the microfluidic device: A microfluidic device including a platform and a cartridge is disclosed. The platform includes a chamber containing a fluid. The reagent cartridge is mounted to the platform. and contains a solid reagent for detecting material contained in the fluid.... Agent: Sughrue Mion, PLLC
20100009432 - Conductive carbon nanotubes dotted with metal and method for fabricating a biosensor using the same: Conductive carbon nanotubes (CNTs) obtained by dotting carboxylated CNTs with metal nanocrystals by chemical functional groups, are described, as well as a method for fabricating a pattern or film of the conductive CNTs which involves repeatedly depositing conductive CNTs on a substrate to achieve high surface density. A biosensor is... Agent: Intellectual Property / Technology Law
20100009433 - Culturing system: The problem of a specimen being vibrated during supply or drainage of a liquid such as a culture solution can be avoided, thus allowing acquisition of a stable image. The invention provides a culturing system including a main container having an opening facing upward, accommodating a culture vessel containing a... Agent: Frishauf, Holtz, Goodman & Chick, PC
20100009434 - Method for the selective enrichment of double-stranded dna from nucleic acid mixtures: The invention relates to a method for stripping undesired nucleic acid components from double-stranded DNA, in particular, super-coiled plasmid DNA. The method according to the invention is characterised by the steps: (a) provision of a mixture containing completely and/or partly double-stranded nucleic acids and optionally single-stranded nucleic acids; (b) resuspension... Agent: Leon R Yankwich Yankwich & Associates
20100009435 - Specific grp78 expression-inhibition rnai sequence, medicine thereof and method thereof: The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5′-AAGGATGGTTAATGATGCTGAGAA-3′ complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration,... Agent: Sinorica, LLC
20100009439 - Anti-igf-i receptor antibodies, dnas, vectors, host cells and genetic constructs: DNAs, vectors, host cells and genetic constructs of antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of these molecules with cytotoxic agents, which specifically bind to and inhibit insulin-like growth factor-I receptor, antagonize the effects of IGF-I and are substantially devoid of agonist activity toward the insulin-like... Agent: Sughrue Mion, PLLC
20100009438 - Dendritic cell potentiation: A molecule capable of potentiating immune responses is described, as well as methods for using the molecule to enhance immune responses and enhance dendritic cell function. Also described are compositions containing the molecule and methods for using the compositions to treat or immunize individuals.... Agent: Fish & Richardson P.C.
20100009436 - High throughput assays for transmissible spongiform encephalopathies (tse): Stable cell lines which produce the pathological form of PrP after infection with the infectious agent for CJD provide a high throughput assay to identify suitable treatment protocols and compositions. The stable cell lines also provide rich source of infectious CJD agent. They also may be used to identify vaccine... Agent: Morrison & Foerster LLP
20100009437 - Isolated proteins mage-4 and mage-41: The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are... Agent: Fulbright & Jaworski, LLP
20100009440 - Spore-like cells and uses thereof: Highly undifferentiated spore-like cells can be isolated from many different tissues and bodily fluids and used to treat a wide variety of disorders.... Agent: Pabst Patent Group LLP
20100009441 - Polynucleotides encoding anti-sulfotyrosine antibodies: The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the invention may be used to discriminate between the non-sulfated and sulfated forms of such proteins, using any number of immunological assays, such ELISAs, immunoblots, Western Blots, immunoprecipitations,... Agent: Los Alamos National Security, LLC
20100009442 - Stem cell culture medium and method: Stem cells such as embryonic stem cells (ES cells), including human ES cells, are cultured in a medium comprising a ROCK inhibitor, and a stem cell culture medium, optionally serum free, comprises a ROCK inhibitor.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20100009446 - Biologically active molecules, particularly based on pna and sirna, method for the cell-specific activation thereof, and application kit to be administered: Biologically active molecules are inactivated for selective activation by target cells by being covalently bonded to one or more peptides each of which has one or more specific amino acid sequences that are selected in respect of enzymes cell-specific for target cells. The bonds, which are broken exclusively by the... Agent: Jordan And Hamburg LLP
20100009443 - Laboratory apparatus for a controlled environment: A controlled environment system for use in In-Vitro Fertilization (IVF) or other biological procedures and a method for conducting such a biological procedure. The system includes a main chamber, one or more manipulator devices for manipulating items in the interior of the chamber, a microscopy viewing system enabling viewing of... Agent: Waddey & Patterson, P.C.
20100009445 - Rare earth nanoparticles: This document provides methods and materials related to rare earth particles such as rare earth nanorods (e.g., inorganic lanthanide hydroxide nanorods). For example, rare earth (e.g., lanthanide) particles such as europium hydroxide nanorods, methods and materials for making rare earth particles (e.g., europium hydroxide nanorods), and methods and materials for... Agent: Sheppard, Mullin, Richter & Hampton LLP
20100009444 - System and method for controlling g-protein coupled receptor pathways: A light-sensitive G-protein coupled receptor includes a light sensitive extracellular domain and a heterologous intracellular domain capable of modulating an intracellular signaling pathway.... Agent: Tarolli, Sundheim, Covell & Tummino, LLP
20100009447 - Vgamma9vdelta2 t cell proliferation agent, method for producing activated vgamma9vdelta2 t cells, and uses thereof: A Vγ9Vδ2 T cell proliferation agent includes at least a bisphosphonate, interleukin 2, and interleukin 18. Since has properties that improve cell viability by inhibiting cell death, IL-18 is presumably capable of acting as a cofactor for the bisphosphonate so as to significantly increase the effect of Vγ9Vδ2 T cell... Agent: Edwards Angell Palmer & Dodge LLP
20100009448 - Biodegradable and bioabsorbable biomaterials and keratin fibrous articles for medical applications: The present invention relates to a process of making biodegradable and/or bioabsorbable biomaterials and keratin nonwoven fibrous articles by electrospinning fibers from a blend of biomaterials and keratin dissolved in organic solvents includes generating a high voltage electric field between oppositely charged biomaterials and keratin fluid in a syringe with... Agent: Evan Law Group LLC
20100009449 - Preparation of vaccine master cell lines using recombinant plant suspension cultures: The subject invention provides a plant cell culture for producing proteinaceous agents comprising a plant cell line stably transformed to express a transgene encoding a proteinaceous agent and a growth medium which supports the growth of said plant cell culture but which does not support the growth of Mycoplasmataceae and... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100009450 - Method for cloning and expressing target gene by homologous recombination: A method for cloning and expressing a target gene by homologous recombination, and more particularly a method for cloning and expressing a target gene by homologous recombination, wherein a host cell transformed with a recombinant vector and a plasmid containing a recombinase system is introduced with a linear DNA fragment... Agent: Intellectual Property / Technology Law
20100009451 - Compositions and methods for specifically silencing a target nucleic acid: The present invention provides methods modified oligonucleotides and methods of using the modified oligonucleotides for silencing nucleic acids, wherein the nonspecific effects of nucleic acid silencing are reduced.... Agent: Polsinelli Shughart PC01/07/2010 > patent applications in patent subcategories. recently filed with US Patent Office
20100003662 - Appliance for cryopreserving collected tissue piece and method for cryopreserving collected tissue piece: An appliance for cryopreserving a collected tissue piece has a cutting position-specifying tool and a tissue piece cryopreserving plate for cryopreserving a tissue piece cut from an organ tissue by the collected tissue cutting position-specifying tool. The collected tissue cutting position-specifying tool has a tissue cutting portion-specifying member having a... Agent: Buchanan, Ingersoll & Rooney PC
20100003663 - Composition for preserving reproductive cells and method of using: Disclosed are compositions for mammalian, avian or piscian reproductive cells and methods for the collection, holding, processing, in vitro fertilization, sexing culturing, or storing (including long-term cryopreservation) of mammalian or avian reproductive sperm cells. The compositions comprise suitable reproductive cell media and antioxidant bioflavonoids. These may be comprised of Oligomeric... Agent: Boyle Fredrickson S.c.
20100003664 - System for glycated protein detection: A method of detecting the presence of glycated proteins or peptides (GPs) in a sample comprises carrying out the steps of assessing the sample for fluorescence, subjecting the sample to UV radiation, and reassessing the sample for an increase in fluorescence relative to any fluorescence assessed in said first assessing... Agent: Dann, Dorfman, Herrell & Skillman
20100003666 - Microfluidic methods for diagnostics and cellular analysis: Methods for detection of molecular recognition and analysis of cells are provided. Both optical and non-optical methods are presented. Methods utilize capture of particles in semi-permeable structures. Specific microfluidic system architectures for conducting biomolecule and cell assays are described.... Agent: Buchanan, Ingersoll & Rooney LLP
20100003667 - Multiple labelling for analyte detection: Provided is use of a label in a method for detecting an analyte in a sample, for increasing the sensitivity of detection of the analyte, wherein, the analyte comprises a repeating protein unit, and wherein a plurality of label entities are capable of binding to a single analyte entity such... Agent: Knobbe Martens Olson & Bear LLP
20100003668 - Oligonucleotides and use thereof for determining deletion in hbv pre-s region: This invention provides combinations of novel oligonucleotides and their use in detecting a deletion(s) in the Pre-S region of HBV. Such a deletion(s) is associated with an increased risk of developing cirrhosis or hepatocellular carcinoma.... Agent: Occhiuti Rohlicek & Tsao, LLP
20100003665 - Real-time hpv pcr assays: The present invention relates a fluorescent multiplex PCR assay for detecting the presence of an HPV type in a sample using multiple fluorophores to simultaneously detect a plurality of HPV genes of the same HPV type, wherein the HPV type is selected from the group consisting of: HPV33, HPV35, HPV39,... Agent: Merck And Co., Inc
20100003674 - Adult stem cells, molecular signatures, and applications in the evaluation, diagnosis, and therapy of mammalian conditions: MicroRNA genes are associated with regulatory elements of living cells of all species. The perturbations of the expression of these genes and their gene products in the cell or genomic structure or chromosomal architecture of a cell provide specific signatures on the condition of the cell and even the organism.... Agent: Patrick P. Phillips Kremblas, Foster, Phillips & Pollick
20100003679 - Assessment of cellular composition and fractional viability and uses thereof: A method of assessing cellular composition and fractional viability that can be predictive of post-transplant cell potency and transplantation outcome, comprises identifying cellular composition and assessing cellular viability. This has particular importance in the field of tissue and cell transplantation, cell therapy and regenerative medicine, providing a method for tissue... Agent: Ropes & Gray LLP
20100003672 - Cdna for human methylenetetrahydrofolate reductase and uses thereof: The invention features methods for diagnosing subjects at risk for or suffering from a disease or disorder, such as a psychosis. Methods are also provided for selecting a preferred therapy for a particular subject or group of subjects.... Agent: Clark & Elbing LLP
20100003670 - Characterizing prostate cancer: Methods and kits for predicting the course or aggressiveness of prostate cancer include detecting the methylation status of various genes.... Agent: Philip S. Johnson Johnson & Johnson
20100003693 - Compositions and methods for detecting the presence of cryptosporidium organisms in a test sample: The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Cryptosporidium organisms, and Cryptosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligonucleotides of the present invention include hybridization assay probes, helper probes and amplification primers.... Agent: Gen Probe Incorporated
20100003690 - Compositions and methods for discovering agents for pharmacological rescue of herg 1b subunits for the treatment of long qt syndrome: Cells engineered to express a detectable hERG 1b polypeptide and methods for identifying agents that facilitate hERG 1b maturation using such cells are provided. A method for analyzing a biological sample for the presence of an amino acid substitution at position 8 of the hERG 1b N-terminus is further provided.... Agent: Quarles & Brady LLP
20100003682 - Compositions, kits, and methods for identification, assessment, prevention and therapy of breast and ovarian cancer: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast or ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast or ovarian cancers are provided.... Agent: Mccarter & English, LLP Boston
20100003683 - Disposable device for analyzing a liquid sample containing a nucleic acid with a nucleic acid amplification apparatus: The invention is directed to a disposable sample holding and processing device (1) dimensioned for being operated in a nucleic acid amplification apparatus for analyzing a liquid sample containing a nucleic acid by a nucleic acid amplification technique. The device (1) comprises chambers (15, 16) and channels (44) designed to... Agent: Roche Molecular Systems, Inc. Patent Law Department
20100003692 - Gamma secretase notch biomarkers: The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized before, after, or concurrently with, pre-clinical,... Agent: Louis J. Wille Bristol-myers Squibb Company
20100003673 - Gene and methods for diagnosing neuropsychiatric disorders and treating such disorders: A mammalian 22444 gene and gene products which are predictive of a susceptibility or predisposition to various neuropsychiatric disorders are provided. Methods of predicting an individual's susceptibility to developing or having a neuropsychiatric disorder via detection of these diagnostic markers are also provided. In addition, compositions and methods for identifying... Agent: Jane Massey Licata Licata & Tyrrell P.C.
20100003681 - Gene polymorphism useful for assistance/therapy for smoking cessation: Disclosed is a method for determination of a smoking trend in a subject which is useful for the assistance or therapy for smoking cessation, which comprises the steps of detecting one or more polymorphisms occurring on one or more genes selected from the genes (1) to (3) or a genome... Agent: Wenderoth, Lind & Ponack, L.L.P.
20100003691 - Genetic markers associated with degenerative disc disease and uses thereof: The present invention relates to novel genetic markers associated with degenerative disc disease (DDD), risk of developing DDD and risk of DDD progression, and methods and materials for determining whether a human subject has DDD, is at risk of developing DDD or is at risk of DDD progression.... Agent: Michael R. Schramm Axial Biotech, Inc.
20100003677 - Identification of tumor suppressor genes in an acute myeloid leukaemia model: Next to the already known tumor suppressor genes Smad1 and Mad1-like, several putative tumor suppressor genes have been found. The tumor suppressing properties of these genes, as indicated in Table 3 also form part of the present invention. Further use of these genes and/or its substrates or downstream products, for... Agent: Leydig Voit & Mayer, Ltd
20100003680 - Method for determining the methylation rate of a nucleic acid: The invention relates to a method for quantitatively determining the methylation rate of a nucleic acid through sequencing. According to the invention, the method comprises at least the following steps: a) treating the nucleic acid with a chemical reagent or an enzyme containing solution, whereby the base pairing behavior of... Agent: Kriegsman & Kriegsman
20100003688 - Methods for molecular detection: This invention relates to methods for molecular detection, particularly to methods utilizing target-specific molecular probes. In exemplary embodiments, target-specific molecular probes include single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) aptamers. In general, the molecular probe may bind with relatively high specificity to a given target. In one aspect, a... Agent: Biotex, Inc.
20100003671 - Nucleotide primer set and nucleotide probe for detecting genotype of n-acetyltransferase-2 (nat2): There is provided a nucleotide primer set for LAMP amplification, used for detecting genotypes of single-nucleotide polymorphisms G590A, G857A and T341C of a NAT2 gene. There is also provided a nucleotide probe for detection of an amplification product amplified with the primer set according to the present invention. There is... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100003685 - Polynucleotide: A polynucleotide consisting of the base sequence of SEQ ID NO: 2, or a complementary strand thereto, wherein the X is one of the group being defined by the bases A, C or T. A primer and a probe specific for that polynucleotide, wherein the primer and/or probe contains at... Agent: Fish & Richardson P.C.
20100003669 - Primer for detection of cytochrome p450 hydroxylase specific to polyene: The present invention relates to a primer for detection of cytochrome P450 hydroxylase specific to polyene and a method for detecting a strain of bacteria which produces polyene, by using the primer. More particularly, the present invention is directed in a forward degenerate primer of following sequence (I) and a... Agent: The Nath Law Group
20100003686 - Process for producing tetracycline inducible gene expressing cell line and conditional gene knockout cell line, and uses thereof: It is intended to provide a method of screening a so-called Tc inducible gene expressing cell line, in which the expression of a gene of interest is regulated depending on the presence/absence of a Tc compound regardless of the type of cell, easily with high efficiency. A gene-of-interest expression vector... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20100003675 - Qtls for mastitis resistance in cattle: The invention relates to a method for determining mastitis resistance in bovine subjects, wherein mastitis resistance comprise resistance to both sub-clinical and clinical mastitis. In particular, the method of the invention involves identification of genetic markers and/or Quantitative Trait Locus (QTL) for the determination of mastitis resistance in a bovine... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP
20100003678 - Sensitive magnetic assay through amplication of a label signal: This invention relates to a device and a method for amplifying a signal generated from primary nanoparticle labels in an assay by using secondary nanoparticle labels, typically magnetic labels, wherein by binding the secondary labels to the primary labels the results in that the signal produced from the labels will... Agent: Philips Intellectual Property & Standards
20100003684 - Single copy genomic hybridization probes and methods of generating same: Nucleic acid (e.g., DNA) hybridization probes are described which comprise a labeled, single copy nucleic acid which hybridizes to a deduced single copy sequence interval in target nucleic acid of known sequence. The probes, which are essentially free of repetitive sequences, can be used in hybridization analyses without adding repetitive... Agent: Polsinelli Shughart PC
20100003687 - System and method for detection of hiv tropism variants: An embodiment of a method for detecting low frequency occurrence of one or more HIV sequence variants associated with drug resistance is described that comprises the steps of: generating cDNA species from each RNA molecule in an HIV sample population; amplifying at least one first amplicon from the cDNA species,... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100003676 - Thermostable dna polymerase of the archaeal ampullavirus abv and its applications: The present invention is directed to the thermostable DNA-polymerase protein of the archaeal ampullavirus ABV (Acidianus Bottle-shaped virus) and the nucleic acid encoding said DNA polymerase. The invention also relates to method of synthesizing, amplifying or sequencing nucleic acid implementing said DNA polymerase protein and kit or apparatus comprising said... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20100003689 - Use of methylation status of mint loci as a marker for rectal cancer: The invention relates to methods for predicting the outcome of rectal cancer and stratifying a rectal cancer treatment according to the level of DNA methylation at MINT 1, 3, 12, or 17. Also disclosed is a method of detecting rectal adenoma or malignancy based on the level of DNA methylation... Agent: Hogan & Hartson L.L.P.
20100003694 - Biomarkers and uses thereof: The present invention provides biomarkers for schizophrenic and bipolar disorders and methods of diagnosis, monitoring and screening associated with the biomarkers and kits for performing such methods.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100003698 - Kit of materials for decreasing interference in results of immunochemical methods: A kit of materials is provided for decreasing or eliminating interference from molecules resulting from upstream immunochemical assays, such as Immunoprecipitation, that employ an Immunoglobulin Binding Molecule (an IBM, e.g., Protein A) in subsequent downstream methods, such as Western Blot. The kit may include packing material, a ligand of an... Agent: Burleson Cooke L.L.P.
20100003697 - Method and apparatus for measuring analyte transport across barriers: The present invention includes a method and apparatus for measuring the transport of analytes through a cell barrier.... Agent: Lawrence R. Oremland, P.C.
20100003696 - Method of diagnosing and monitoring the progress of multiple sclerosis, and the use of a test kit therefor: There is a described method and a test kit for diagnosing and monitoring the progress of multiple sclerosis by determining autoantibodies in bodily fluids by determining those antibodies which bind to a spectrin. A typical spectrin is alpha-fodrin.... Agent: Buchanan Ingersoll & Rooney PC
20100003695 - Microwave trigger metal-enhanced chemiluminescence (mt mec) and spatial and temporal control of same: The present invention relates to a method of imaging structures and features using plasmonic emissions from metallic surfaces caused by chemiluminescence based chemical and biological reactions wherein imaging of the reactions is enhanced by the use of microwave energy and further enhanced by using metallic geometric structures for spatially and... Agent: Moore & Van Allen PLLC
20100003700 - Optoelectronic sensor: A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20100003699 - Tissue carbohydrate compositions and analysis thereof: The present invention reveals novel methods for producing novel carbohydrate compositions, glycomes, from animal tissues. The tissue substrate materials can be total tissue samples and fractionated tissue parts, or artificial models of tissues such as cultivated cell lines. The invention is further directed to the compositions and compositions produced by... Agent: Birch Stewart Kolasch & Birch
20100003703 - Assay system for glp-2 receptor ligands: Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue.... Agent: Stoel Rives LLP - Slc
20100003704 - In situ detection of early stages and late stages hpv infection: Embodiments of the invention provide methods, polyclonal antibodies, monoclonal antibodies, assays, and kits for detecting HPV infection, including infection by various HPV genotypes, early and/or late HPV-associated or HPV-specific proteins or antibodies. Mononoclonal antibodies are used to detect oncogenic high risk and low risk HPV types in a single assay,... Agent: Shuling Cheng
20100003705 - Cln101 antibody compositions and methods of use alone and in combination with prostate specific antigen and other cancer markers: This invention relates to a method for assessing risk of prostate and/or ovarian cancer. Specifically, in one embodiment it relates to utilizing both Cln101 and Prostate Specific Antigen (PSA) in combination to determine the risk of prostate cancer. In an alternative embodiment, the invention is relates to utilizing Cln101 alone... Agent: Licata & Tyrrell P.C.
20100003706 - Syphilis diagnostic tests and kits: The present invention provides methods and kits for determining whether a human subject is infected with T. pallidum and isolated polypeptide fragments of T. pallidum proteins Tp92, Tp0453, and Gpd that can be used in the methods and kits of the invention.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20100003701 - Covalent modification and conjugation of luciferase: A process for reversible chemical modification of the luciferase, a process for the covalent conjugation of a reversibly modified luciferase to a chemical moiety (a protein or a binding partner such as biotin or an antibody), a process for reactivation of the reversibly-modified and inactivated luciferase, a process for making... Agent: Leydig Voit & Mayer, Ltd
20100003702 - Procedure and device for determining the concentrations of at least two ligands: In a procedure for determining the concentrations of ligands contained in a sample wherein a first ligand is bond-specific to a first receptor and a second ligand is bond-specific to a second receptor, the first receptor is immobilized on a first test site and the second receptor is immobilized on... Agent: The Webb Law Firm, P.C.
20100003707 - Glaucoma biomarker: According the present invention, Brain Derived Neurotrophic Factor (BDNF) in the tears or blood is used as a biomarker for early detection and assessing the progression of POAG. A reduced level of BDNF compared to normal range can be the sign of POAG. Lower levels of BDNF represent more advanced... Agent: Mahmoud Razzaghi
20100003708 - Lipolytic enzyme variants: Lipolytic enzyme variants with increased specificity for short-chain fatty acids can be designed on the basis of a three-dimensional model of a lipolytic enzyme such as C. antarctica lipase A with a substrate analogue such as a fatty acid. An amino acid residue is selected within 10 Å of the... Agent: Novozymes North America, Inc.
20100003709 - Crystal structure of enzyme and uses thereof: This invention relates to crystallised human neutrophil elastase and the use of its three-dimensional structure to design modulators for human neutrophil elastase.... Agent: Barbara A. Shimei Director, Patents & Licensing
20100003710 - Electrochemical assay for the detection of enzymes: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process.... Agent: Morgan, Lewis & Bockius, LLP (sf)
20100003712 - Biomarker for assessing response to chymase treatment: A biomarker that correlates to treatment with drugs that inhibit chymase is disclosed. This biomarker has been shown to have utility in assessing response to chymase inhibitor compounds. The immunoreactivity or levels of the biomarker is increased upon treatment with chymase inhibitor compounds, thus indicating that this biomarker is involved... Agent: Philip S. Johnson Johnson & Johnson
20100003713 - Methods of determination of iron deficiency and hemochromatosis: New diagnostic parameters or indexes for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency have been disclosed. The parameters include a RBC size factor, RSf1 defined by the formula of (MCV×MRV)1/2, or RSf2 defined by the formula of (MCV×MRV)/100, a volume-hemoglobin factor... Agent: Beckman Coulter, Inc. Mitchell E. Alter
20100003711 - Methods to identify therapeutic agents: As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cholesterol oxidation or ozonation products that can act as chemotactic attractants of macrophages, can promote differentiation of monocytes into macrophages and can increase expression of E-selectin and Class A scavenger receptor (SR-A). The present... Agent: The Scripps Research Institute
20100003714 - System and method for determining fill volume in a container: A system and method for detecting a pathogen in a sample is provided, the system capable of measuring the volume of a sample in a container through the use of various measurement technologies, thereby ensuring that a user is aware of volumes not meeting specification and/or allowing correction of results... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20100003715 - Biological agent detection and identification system: A sample under test containing non-live and/or live particulates is subject to optical excitation on a single particle-by-particle basis or as a small group of particulates sufficient to induce a subsequent fluorescence emission that is observed for a selected period of time by a sensor, typically a photomultiplier tube. The... Agent: Wallace G. Walter
20100003716 - Isoprene synthase variants for improved microbial production of isoprene: The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture... Agent: Morrison & Foerster LLP
20100003717 - Closed-loop system for growth of algae or cyanobacteria and gasification of the wet biomass: Processes, systems, and methods for producing combustible gas from wet biomass are provided. In one aspect, for example, a process for generating a combustible gas from a wet biomass in a closed system is provided. Such a process may include growing a wet biomass in a growth chamber, moving at... Agent: Thorpe North & Western, LLP.
20100003720 - Enzyme derived from thermophilic organisms that functions as a chromosomal replicase, and preparation and uses thereof: A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus, and corresponds to Polymerase III in E. coli. The genes and the polypeptides corresponding to T.th. γ, τ, ε, α and... Agent: Nixon Peabody LLP - Patent Group
20100003718 - Method and apparatus for the production of soluble mhc antigens and uses thereof: The field of the invention relates in general to at least one method and apparatus for the production of soluble MHC antigens and more particularly, but not by way of limitation, to at least one method and apparatus for the production of soluble Class I and II HLA molecules. The... Agent: Dunlap Codding, P.C.
20100003719 - Trimerising module: The present invention relates to the design of trimeric polypeptides using polypeptide structural elements derived from the tetranectin protein family, and their use in rational de novo design and production of multi-functional molecules including the application of the multi-functional molecules in protein library technology, such as phage display technology, diagnostic... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20100003721 - Human interferon-beta mutein: The present invention relates to a human interferon-beta mutein. In particular, the present invention relates to the human interferon-beta mutein having one or two additional sugar chains compared to natural human interferon-beta.... Agent: Lucas & Mercanti, LLP
20100003722 - Production and purification of il-29: The expression vectors and methods using an E. coli expression system for the large scale production of IL-29 are described. The vectors utilize the IL-29 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Also included are methods... Agent: Zymogenetics, Inc. Intellectual Property Department
20100003724 - Chemically modified nucleoside 5'-triphosphates for thermally initiated amplification of nucleic acid: Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3′-substituted nucleoside 5′-triphosphates or 3′-substituted terminated primers in nucleic acid replication reactions. In certain aspects, the methods are accomplished by use of 3′-substituted NTPs and/or 3′-substituted terminated primers which provide utility in nucleic acid... Agent: Foley & Lardner LLP
20100003725 - Low-mass sample block with rapid response to temperature change: A sample block for use in the polymerase chain reaction, DNA sequencing, and other procedures that involve the performance of simultaneous reactions in multiple samples with temperature control by heating or cooling elements contacting the bottom surface of the block is improved by the inclusion of hollows in the block... Agent: Townsend And Townsend And Crew, LLP
20100003723 - Rna-dependent dna polymerase from geobacillus stearothermophilus: The invention relates to an isolated polynucleotide sequence from the genome of Bacillus stearothermophilus (Geobacillus stearothermophilus) and an amino acid sequence encoded by the polynucleotide sequence, the corresponding amino acid sequence comprising a novel enzyme, Tirt (thermostable intron reverse transcriptase), having reverse transcriptase activity and retaining that activity at temperatures... Agent: Donna J. Russell
20100003726 - Process for producing l-glutamic acid: L-glutamic acid is produced by culturing a microorganism in a liquid medium containing L-glutamic acid at a saturation concentration, wherein the microorganism can metabolize a carbon source at a specific pH, and also has an ability to accumulate L-glutamic acid in the medium in an amount which exceeds the saturation... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC
20100003728 - Isolation of cyclopamine: Provided are deglycosylation methods designed to optimize the yield of Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum plant material.... Agent: Foley Hoag, LLP (w/ipx)
20100003729 - Method for producing optically active succinimide compound: There is provided a novel method for producing an optically active succinimide compound which is a useful compound utilized as an intermediate raw material for pharmaceutical products or the like. The method for producing an optically active succinimide compound of formula (2) comprises processing a racemic compound of a succinimide... Agent: Oliff & Berridge, PLC
20100003730 - Enzymatic synthesis of acetoacetate esters and derivatives: In one embodiment, the present invention includes a method for the synthesis of an ester derivative of acetoacetate. The method includes providing a first ester of acetoacetate and providing an alcohol. The method further includes combining the first ester of acetoacetate and the alcohol in the presence of an enzyme... Agent: Swanson & Bratschun, L.L.C.
20100003731 - Process for producing lactic acid: The present invention provides microorganisms, in which the activity of 4-hydroxybenzoate polyprenyltransferase or 2-octaprenylphenol→2-octaprenyl-6-methoxyphenol flavin reductase is reduced or lost, and which have an ability to produce lactic acid, in particular, microorganisms comprising a chromosomal DNA in which a gene encoding a protein having 4-hydroxybenzoate polyprenyltransferase activity or a protein... Agent: Townsend And Townsend And Crew, LLP
20100003732 - Process for production of optically active 2-substituted propanal derivative: The present invention relates to a process for producing an optically active 2-substituted propanal derivative, and more particularly, a process for producing an optically active 2-substituted propanal derivative which comprises stereoselectively reducing a carbon-carbon double bond of a 2-substituted acrolein derivative by using an enzyme source capable of stereoselectively reducing... Agent: Sughrue Mion, PLLC
20100003733 - Recovery of inorganic salt during processing of lignocellulosic feedstocks: A method for recovering inorganic salt during processing of a lignocellulosic feedstock is provided. The method comprises pretreating the lignocellulosic feedstock by adding an acid to the feedstock to produce a pretreated lignocellulosic feedstock. A soluble base is then added to the pretreated lignocellulosic feedstock to adjust the pH and... Agent: Fitzpatrick Cella Harper & Scinto
20100003734 - Production of recombinant photosynthetic bacteria which produces molecular hydrogen in a light independent manner and hydrogen evolution method using above strain: A method of making a photosynthetic bacteria variant which that can produce hydrogen in both day and night. In one embodiment hydrogen is produced in a light independent manner by adding pyruvate lyase and formate lyase complex to a photosynthetic strain of Rhodobacter sphaeroides. A preferred photosynthetic bacteria variant that... Agent: Mcnair Law Firm, P.A.
20100003735 - Mild chemically cleavable linker system: A linker system is provided where a small molecule reactive group, e.g., an activity based probe which binds to certain enzymes at the active site, is linked through an aryl diazo linker to an affinity molecule such as biotin. The reactive group may comprise a number of functionalities known to... Agent: Peters Verny , L.L.P.
20100003736 - Polynucleotides encoding novel pcsk9 variants: The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the... Agent: Louis J. Wille Bristol-myers Squibb Company
20100003737 - Partially fluorinated sulfonated surfactants: e
20100003738 - Plasmid curing: The present invention relates to plasmid curing, and particularly to efficient and stress-free methods for displacing resident or endogenous plasmids from a host cell, such as a bacterium. The invention extends to method of displacing a plasmid comprising a post-segregational killing system from a host cell, the method comprising introducing... Agent: Berliner & Associates
20100003739 - Selection of adh in genetically modified cyanobacteria for the production of ethanol: The present invention discloses genetically-modified cyanobacteria with ethanol-production capabilities enhanced over the currently-reported art, and methods of making such cyanobacteria. The invention provides a genetically modified photoautotrophic, ethanol producing host cell comprising an overexpressed pyruvate decarboxylase enzyme converting pyruvate to acetaldehyde and an overexpressed Zn2+ dependent alcohol dehydrogenase enzyme converting... Agent: Algenol Biofuels, Inc.
20100003740 - Chemically defined culture medium for neisseria: There is provided a chemically-defined liquid culture medium comprising an energy source, a carbon source, a nitrogen source, an amino acid source, a purine synthesis source, a pyrimidine synthesis source and a buffer; characterised in that the culture medium has a pH less than 7, preferably less than 6.9, most... Agent: Evan Law Group LLC
20100003741 - Integrated power plant, sewage treatment, and aquatic biomass fuel production system: Two waste products, nitrate-rich sewage wastewater and power plant CO2 emissions, are combined and converted into a renewable, biomass energy source, which supplies the fuel to the power plant. The power plant, wastewater treatment facility, and biomass growth unit are preferably located on one site and arranged for convenient transfer... Agent: Alix Yale & Ristas LLP
20100003742 - Method for reducing fucose contents of recombinant proteins: The present invention relates to a method for reducing the fucose content of a recombinant protein, which comprises expressing in an animal cell the recombinant protein and FUCA1, an FUCA1 mutant, FUCA2, or a fragment of FUT8 localization domain; or with a fusion protein of a fragment of FUT8 localization... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100003744 - Flow cytometer for diagnosis of hiv infections: Disclosed is a a flow cytometer for diagnosis of HIV infections. A fluorescent material having a relatively lower fluorescence intensity is conjugated with one marker and another fluorescent material having a relatively higher fluorescence intensity is conjugated with the other marker. The two markers can be sorted and counted individually... Agent: Edwards Angell Palmer & Dodge LLP
20100003743 - Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor: A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20100003745 - Cell culture vessel: A cell culture vessel for culturing adherent cells includes a channel allowing liquid to flow therethrough; a culture surface disposed on a wall of the channel, the culture surface allowing the adherent cells to adhere thereto; an inlet for introducing the liquid into the channel; an outlet for draining the... Agent: Canon U.s.a. Inc. Intellectual Property Division
20100003746 - Production of lentiviral vectors: The present invention is a method of generating a lentivirus vector, comprising cloning each of a leotivimus transfer construct, gag, pol, an envelope protein and rev respectively into the same or different baculoviruses, and transducing a producer cell with the or each baculovirus.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20100003748 - Compositions, systems, and methods for stabilization of a cell and/or macromolecule: The present disclosure relates to compositions, systems, and methods for stabilizing a cell (e.g. a whole cell), a biomolecule, and/or a macromolecule. A biomaterial stabilizing composition may include a chelator, a chelator enhancing component, a base (e.g., a purine base or a pyrimidine base), and optionally a protease inhibitor and/or... Agent: King & Spalding LLP
20100003747 - Cultured xenopus laevis cell lines expressing mutant adenomatous polyposis coli gene: Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these cells showed that mutant APCs, whose C-terminal region is absent, induced piling up of cells. Furthermore, piled up cells from mutant APC-expressing cell... Agent: Townsend And Townsend And Crew, LLP
20100003749 - Enriched pancreatic stem cell and progenitor cell, populations, and methods for identifying, isolating and enriching for such populations: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating, and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20100003750 - Making encoded ghost cells for multiplexed detection of anti-red cell alloantibodies: Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events between a particular antigen antibody pair (as in traditional agglutination based assays) the methods herein allow for multiplexed detection... Agent: Eric P. Mirabel
20100003751 - Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20100003752 - Liver progenitor cells: The invention relates to human liver pluripotent progenitor cell lines which express hepatic cell markers such as albumin and α-fetoprotein and do not express some of the markers which are typical of oval stem cells. Also disclosed is a method of isolating the cell lines of the invention, methods for... Agent: Jacobson Holman PLLC
20100003754 - Methods of differentiating stem cells: A method for at least partial differentiating stem cells and/or progenitor cells to at least one tissue type includes treating the stem cells and/or the progenitor cells with extracts which include active substances and/or components for differentiating stem cells and/or progenitor cells, and cultivating and differentiating the stem cells and/or... Agent: Ip Group Of Dla Piper LLP (us)
20100003753 - Multivalent rna nanoparticles for delivery of active agents to a cell: A polyvalent multimeric complex formed from a plurality of chimeric pRNA molecules, each carrying at least one biologically active moiety, detectable label, or other heterologous component.... Agent: Seed Intellectual Property Law Group PLLC
20100003756 - Methods and compositions for generation of bax-and bak-deficient cell lines: Disclosed herein are methods and compositions for generation of Bak- and/or Bax-deficient cell lines using engineered nucleases.... Agent: Robins & Pasternak
20100003758 - Methods and compositions for the specific inhibition of gene expression by double-stranded rna: The invention provides compositions and methods for selectively reducing the expression of a gene product from a desired target gene, as well as treating diseases caused by expression of the gene. The method involves introducing into the environment of a cell an amount of a double-stranded RNA (dsRNA) such that... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20100003755 - Methods for identifying genomic deletions: The genomic locus responsible for Van Buchem's disease is narrowed to an approximately 92 kb region of human chromosome 17 at 17q21. Individuals afflicted with or carriers of Van Buchem's disease exhibit a 52 kb deletion within this 92 kb region. Methods are provided that permit the differentiation between individuals... Agent: C. Rachal Winger C/o Ocip Group
20100003757 - Methods for the production of ips cells using non-viral approach: Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements... Agent: Fulbright & Jaworski L.L.P.
20100003759 - Targeted dna insertion in plants: Methods and means are provided to improve targeted DNA insertion in plants using rare-cleaving “double stranded break” including enzymes. Also provided are improved I-SceI encoding nucleotide sequences.... Agent: Hunton & Williams LLP Intellectual Property DepartmentPrevious industry: Education and demonstration
Next industry: Chemistry: analytical and immunological testing
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