|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology December patent applications/inventions, industry category 12/09Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 12/31/2009 > patent applications in patent subcategories.
20090325143 - Blood separation media: Disclosed is a separation media, comprising an upstream layer, comprising fibers, wherein the upstream layer has a mean flow pore size of 8 microns or less; and a downstream layer, comprising fibers. The separation media is designed to separate red blood cells from liquid specimens such as blood and allow... Agent: Birch Stewart Kolasch & Birch
20090325144 - Swine sperm dilution media containing milk protein: The present invention discloses the application of a protein fraction from milk in dilution media for swine sperm. Compositions that contain this protein fraction show an improved and more economical performance. The present invention relates primarily to dilution media for swine sperm aimed at maintaining and/or improving the vitality of... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090325148 - Bead array reader based-hemagglutination and hemagglutination inhibition assay: Hemagglutination assays and hemagglutination inhibition assays were introduced in medical and virology practice more than 60 years ago. Since then, these assays have become important tools for measuring concentrations and strengths of viral cultures, the efficacy of the anti-viral immunization, and for studying the neutralizing capacity of virus-specific antibodies. The... Agent: Merchant & Gould PC
20090325149 - Detection and distinguishing infections bursal disease virus (ibdv) strains by molecular biology method: The present invention relates to a novel method to detect and differentiate different strains of infectious bursal disease virus (IBDV) in a chicken and other bird sample. RNA was obtained from said samples by using a pair of primer (Primer FVVC & RVVC) in a reverse transcriptase-polymerase chain reaction. Two... Agent: Wolf Greenfield & Sacks, P.C.
20090325146 - Method of determining susceptibility of a tumor cell to a chemotherapeutic agent: novel use of herpes: The present invention provides a method of determining if a tumor cell is susceptible to killing by a chemotherapeutic agent, comprising: (a) providing a tumor cell; (b) infecting said tumor cell with a herpes simplex virus or a herpes simplex virus defective in an immediate early gene selected from the... Agent: Medical Diagnostic Laboratories, LLC
20090325145 - Methodology for analysis of sequence variations within the hcv ns5b genomic region: The current invention relates to a standardized method for amplification of an HCV NS5B nucleic acid fragment of any one of HCV genotypes 1 to 6 as a tool for analysis of sequence variations that may be correlated with HCV drug resistance.... Agent: Nixon & Vanderhye, PC
20090325147 - Molecularly imprinted polymers for detecting microorganisms: The invention described herein provides molecularly imprinted polymers (MIPs) that are capable of binding to a microorganism, and methods for detecting and/or identifying microorganisms utilizing Molecularly Imprinted Polymers (MIPs). The microorganisms of the invention include prokaryotes, eukaryotes, virus and prions. The methods of the invention comprise detecting all or part,... Agent: Womble Carlyle Sandridge & Rice, PLLC
20090325158 - 5-bromo-2'-deoxy-uridine labeled nucleotide triphosphates and nucleic acid probes and methods of making and using the same: 5-bromo-2′-deoxy-uridine (BrdU) labeled nucleotide triphosphates and nucleic acid probes are described herein. The BrdU labeled nucleotide triphosphates include a linker between the nucleotide triphosphate and the BrdU moiety. The linker can be cleavable or non-cleavable. The nucleotide triphosphates can be a ribonucleotide triphosphates, 2′-deoxyribonucleotide triphosphates or 2′,3′-dideoxyribonucleotide triphosphates. The nucleic... Agent: Morris Manning Martin LLP
20090325153 - Analysis of heterogeneous nucleic acid samples: Methods for capturing and characterizing low frequency nucleic acid molecules indicative of diseases such as cancer (e.g. adenomas or early stage cancers) are provided. In some aspects, a low complexity capture technique is combined with a high complexity analytical technique. In some aspects, samples may be analyzed using a digital... Agent: Choate, Hall & Stewart LLP
20090325155 - Aureobasin a synthetase: Disclosed are polynucleotides encoding polypeptides having Aureobasidin A synthetase activity and Aureobasidin A synthetase-like activity. The invention also provides methods for detecting AbA synthetase proteins and nucleic acids and AbA synthetase-like proteins and nucleic acids in cells, and method for producing AbA synthetase polypeptides.... Agent: Honigman Miller Schwartz & Cohn LLP
20090325184 - Compositions and methods for clonal amplification and analysis of polynucleotides: Compositions and methods of use are disclosed for clonally amplifying and analyzing one or more polynucleotides.... Agent: Life Technologies Corporation C/o Intellevate
20090325160 - Compositions and methods for prognosis and therapy of liver cancer: This invention provides a composition comprising the following polynucleotide probes: IL7R (AA485865) (SEQ ID NO:7), NDRGI (AA486403) (SEQ ID NO:8), EST1 (H50345) (SEQ ID NO:9), TRPC1 (AA017132) (SEQ ID NO:10), GFRA1 (AA512935) (SEQ ID NO:11), EST2 (AA454543) (SEQ ID NO:12), CLDN10 (R54559) (SEQ ID NO:13), DNALI1 (R93087) (SEQ ID NO:14),... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090325180 - Drug screening using islet cells and islet cell progenitors from human embryonic stem cells: This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High quality populations of islet cells can be produced in commercial quantities for use in research,... Agent: Geron Corporation Attn. David J. Earp
20090325162 - Fatty acid synthetase, polynucleotide encoding the same, and uses thereof: The present invention provides fatty acid synthetases which are responsible for novel fatty acid synthesis, polynucleotides which encode such fatty acid synthetases (e.g., a polynucleotide comprising (a) a polynucleotide consisting of the nucleotide sequence of Positions 1 to 12486 of SEQ ID NO: 1, or (b) a polynucleotide which hybridizes... Agent: Greenblum & Bernstein, P.L.C
20090325176 - Gene expression profiles associated with asthma exacerbation attacks: The present invention provides methods for the assessment, diagnosis, or prognosis of asthma exacerbation, by assessing the level of expression of asthma exacerbation gene products in a sample derived from a patient. The markers of the present invention can be used in methods to identify or evaluate agents capable of... Agent: Wyeth Patent Law Group
20090325163 - Genetic markers for risk management of cardiac arrhythmia: The invention relates to procedure and methods of determining a susceptibility to cardiac arrhythmia, including Atrial Fibrillation, Atrial Flutter and Stroke, by assessing the presence or absence of alleles at polymorphic markers found to be associated with Atrial Fibrillation, Atrial Flutter and Stroke. The invention further relates to kits encompassing... Agent: Marshall, Gerstein & Borun LLP
20090325168 - Homo-doubly labeled compositions for the detection of enzyme activity in biological samples: The present invention provides for novel reagents whose fluorescence changes upon cleavage or a change in conformation of a backbone. The reagents comprise a backbone (e.g. nucleic acid, polypeptide, etc.) joining two fluorophores of the same species whereby the fluorophores form an H-dimer resulting in quenching of the fluorescence of... Agent: Weaver Austin Villeneuve & Sampson LLP
20090325161 - Kit and method for quantitatively detecting multiplepathogens without gene amplification: A non-amplification multiple quantitative detection kit is characterized in that there are provided a single strand poly nucleotide having a base sequence invented to recognize a specific gene portion of a multilepathogens microorganism to be detected by a fishing probe, and a double strand poly nucleotide indicated with a tag... Agent: LexyoumeIPGroup, LLC
20090325150 - Klf6 alternative splice forms and a germline klf6 dna polymorphism associated with increased cancer risk: Disclosed are methods of identifying and diagnosing certain types of cancers and pre-stages thereof in a patient by identifying alternatively spliced isoforms of wild type KLF6 (KLFwt), in particular anyone of the isoforms selected from the group consisting of: KLF6 splice variant-1 (KLF6SV1), KLF6 splice variant-2 (KLF6SV2), and KLF6 splice... Agent: Darby & Darby P.C.
20090325156 - Materials and methods for abcb1 polymorphic variant screening, diagnosis, and treatment: The invention provides methods and materials for screening for polymorphic variants in ABCB1 and diagnosing altered susceptibilities for drug-induced heart rhythm irregularities based on the same. These methods allow better treatment regimens for using drugs that bind a protein encoded by the ABCB1 and/or induce heart rhythm irregularities such as... Agent: Leydig, Voit & Mayer, Ltd.
20090325170 - Means and methods for diagnosing and/or treating a subject at risk of developing heart failure: The present invention relates to a method for identifying a subject at risk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample of said subject; (b) comparing the level of said biological marker to a standard level of the same... Agent: Bozicevic, Field & Francis LLP
20090325178 - Method for testing the response of cells to exposure with therapeutics: The invention relates to methods for testing the response of spheroids to exposure with therapeutics. Preferably the spheroids are derived from primary isolate biological tissue and/or cell-containing bodily fluid. Further embodiments relate to spheroid sections and arrays including kits suitable for carrying out the method according to the present invention.... Agent: Ratnerprestia
20090325185 - Method of analyzing expression of gene: A cDNA is prepared from mRNA. The prepared cDNA is subjected to incision with two different types of restriction enzymes. The sequence of a portion of each of the fragments obtained as a result of treatment is determined, and the fragments are classified on the basis of the determined sequence... Agent: Cooper & Dunham, LLP
20090325167 - Method of using cytokine assay to diagnose, treat, and evaluate inflammatory and autoimmune diseases: The invention provides methods for diagnosing, treating, or evaluating inflammatory and autoimmune diseases by sampling peripheral blood, serum, plasma, tissue, cerebrospinal fluit, or other bodily fluids from a human subject having a suspected diagnosis. The sample is analyzed for the presence and amount of certain cytokines, which provides the diagnosis,... Agent: Townsend And Townsend And Crew, LLP
20090325181 - Methods and compositions for the specific inhibition of gene expression by double-stranded rna: The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090325173 - Methods and kits useful for detecting an alteration in a locus copy number: A method of identifying an alteration in a locus copy number is provided. The method is effected by determining a methylation state of at least one gene in the locus, wherein a methylation state differing from a predetermined methylation state of the at least one gene is indicative of an... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090325182 - Methods for detecting a cyclophilin b snp associated with herda: This invention provides compositions and methods for identification of carriers of Hereditary Equine Regional Dermal Asthenia (HERDA) in equine species. In particular, this invention identifies a single nucleotide polymorphorism (SNP) in cyclophlin B that can be used to identify carriers of HERDA and individuals affected by HERDA.... Agent: Townsend And Townsend And Crew, LLP
20090325179 - Methods for detecting thiol-containing nucleotide diphosphates with thiol-reactive fluorescent reagents: Disclosed are methods for detecting thiol-containing nucleotide diphosphates. The methods utilize thiol-reactive fluorescent reagents.... Agent: Andrus, Sceales, Starke & Sawall, LLP
20090325175 - Methods of detection and quantification of host cell dna contamination of purified proteins: The present invention provides a novel robust, sensitive, reproducible, and accurate method of detecting and quantifying host cell genomic DNA contamination utilizing quantitative real time Polymerase Chain Reaction (qPCR), wherein the qPCR primers are complementary to the highly repetitive host cell genomic DNA sequences, e.g., Alu-equivalent sequences. The present invention... Agent: Wyeth Patent Law Group
20090325164 - Microelectronic sensor device for dna detection: The invention relates to a microelectronic sensor device and a method for the investigation of biological target substances (20), for example oligonucleotides like DNA fragments. In one embodiment, the device comprises a reaction surface (RS) to which target specific reactants (10) are attached and which lies between a sample chamber... Agent: Philips Intellectual Property & Standards
20090325172 - Modified nucleotides: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O-Z wherein Z is any of —C(R′)2-O—R″,... Agent: Klauber & Jackson
20090325157 - Pathogen detection and screening: Disclosed is a rapid dual purpose PCR based method for identifying two or more pathogens in a sample, such as a stool or environmental (soil, water) sample, including Giardia and/or Cryptosporidium in a single real-time PCR reaction. This is of particular utility in the screening and detection of pathogen(s) in... Agent: K&l Gates LLP
20090325151 - Pharmacogenomics of blood pressure lowering agents: A method of determining a suitable blood pressure lowering treatment for an individual comprises a step of assaying a biological sample from the individual for the presence or absence of the C-5312T SNP in a distal enhancer region of the renin gene. The presence of at least one T allele... Agent: Occhiuti Rohlicek & Tsao, LLP
20090325154 - Pyrosequencing methods and related compositions: This invention provides methods for pyrosequencing and compositions comprising 3′-O— modified deoxynucleoside triphosphates.... Agent: Cooper & Dunham, LLP
20090325174 - Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders: Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter.... Agent: Licata & Tyrrell P.C.
20090325165 - Recombinase polymerase amplification: This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of the bacterial RecA and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods has the advantage of... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo
20090325169 - Rnase h-based assays utilizing modified rna monomers: The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3′ end of the oligonucleotide. These compounds offer an added level... Agent: Integrated Dna Technologies, Inc. C/o Darby & Darby P.C.
20090325177 - Sensitive and rapid methods of using chimeric receptors to identify autoimmune disease and assess disease severity: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much... Agent: Peter G. Carroll Medlen & Carroll, LLP
20090325183 - Sequencing methods: The present teachings provide methods and compositions for sequencing one or more target nucleic acids. High levels of multiplexing are provided by the use of an emulsion PCR comprising primer-immobilized beads. The resulting reaction products can be sequenced by any of a variety of mobility-dependent analytical techniques, such as mass... Agent: Life Technologies Corporation C/o Intellevate
20090325166 - Substrates for performing analytical reactions: Substrates, including zero mode waveguide substrates that have been fabricated to provide additional functional elements and/or components including increased volumes for positioning of active surfaces and/or components for the mitigation of negative electrochemical properties of the underlying substrates.... Agent: Pacific Biosciences Of California, Inc.
20090325159 - System and method to prevent cross-contamination in assays performed in a microfluidic channel: The present application discloses systems and methods for preventing contamination in assays performed in microfluidic channels. In one embodiment, a buffer of non-reactive fluid is provided between an input port and a microchannel in which assays are performed during such times that flow from the input port is stopped. In... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090325152 - Use of gene activity classifiers for the in vitro classification of gene expression profiles of patients with infectious/non-infectious multiple organ failure: The present invention in particular relates to gene activity markers for classification of patients as “not infected without multiple organ failure” or as “not suffering from infectious multiple organ failure” or as “suffering from infectious multiple organ failure”, the gene activity markers being polynucleotides selected from the group consisting of:... Agent: Patent Central LLC Stephan A. Pendorf
20090325171 - Vesicles for use in biosensors: Vesicles for use in biosensors that have both high specificity and high sensitivity, where the vesicles include a receptor specific for the intended analyte and a signal generating component.... Agent: Law Office Of Collen A. Beard, LLC
20090325187 - Immunomodulation: In a further aspect, the present invention relates to the medical treatment of human beings using ILT6 to modulate their immune response, for example directed against heterologous and/or autologous antigens. Furthermore, the present invention relates to the analysis using ILT6 for diagnostic purposes and to diagnostic compositions that can be... Agent: Greer, Burns & Crain
20090325186 - Method for detecting analytes in a sample:
20090325188 - Method for detecting il-16 activity and modulation of il-16 activity based on rantes proxy levels: Methods for detecting IL-16 biological activity, detecting modulation of IL-16 biological activity, and diagnosing the presence of or susceptibility of a subject to an IL-16-related disorder involve measuring and comparing the levels of RANTES proxy produced by eukaryotic cells, such as CD4+ and CD9+ cell lines, peripheral blood mononuclear cells,... Agent: Philip S. Johnson Johnson & Johnson
20090325190 - Method for quantitative detection of diabetes related immunological markers: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of diabetes related immunological makers in a serum sample, which can be used to diagnose and/or early diagnose diabetes as well as to predict the onset risk of diabetes in first-degree relatives. It also discloses an efficient... Agent: Weili Cheng
20090325191 - Method for the diagnosis of pathological conditions in animals: A method for diagnosing a disease or pathological condition in a non-human animal. An ion mobility spectrometry measurement (IMS) or a differential mobility spectrometry (DMS) is carried out on a body sample from the animal to determine an amount of ions formed by at least two biogenic amines contained in... Agent: Lerner, David, Littenberg, Krumholz & Mentlik
20090325189 - Tyrosine phosphorylation sites: The invention discloses 443 novel phosphorylation sites identified in leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel
20090325192 - Rapid particle detection assay: The present invention proves instruments and methods for detecting and/or quantitating an analyte in a fluid sample. The fluid sample is placed in a sample chamber having a small, shallow detection region. The analyte is magnetically labeled using magnetic particles coated with a binding reagent, and is detectably labeled using... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20090325197 - Assay for immunosuppressant drugs: The invention provides immunoassays for immunosuppressant drugs, wherein the assay is carried out under high salt conditions to achieve improved sensitivity. The invention also provides kits that are useful for performing the methods of the invention.... Agent: Paul D. Yasger Abbott Laboratories
20090325196 - Levels of bcma protein expression on b cells and use in diagnostic methods: The present invention provides a method of measuring the levels of BCMA in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an... Agent: Alston & Bird LLP
20090325198 - Non-denaturing lysis reagent for use with capture-in-solution immunoassay: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and non-specific animal immunoglobulins.... Agent: Paul D. Yasger Abbott Laboratories
20090325201 - Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma: Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.... Agent: Venable LLP
20090325202 - Methods for developing and assessing therapeutic agents: Assays are provided that can effectively assess tumor response to one or more therapeutic agents. Preferred assays of the invention include assessment of posttranslation modification and expression of target proteins.... Agent: Edwards Angell Palmer & Dodge LLP
20090325199 - Nanostructures for polarized imaging and receptor/ligan quantization: breaking the diffraction limit for imaging: The present invention relates to affinity biosensing using polarization of light scattering of aggregated noble metallic nanostructures to determine concentration of an analyte in a test sample. This new sensing system utilizes the changes in polarized plasmonic scattering from nanostructures as the nanostructures aggregate due to binding of the analyte... Agent: Moore & Van Allen PLLC
20090325200 - Polypyrimidine-tract binding protein (ptb) as a biomarker and target for the diagnosis and treatment of cancer: The present invention provides a method of diagnosing cancer in a mammalian subject comprising measuring the level of polypyrimidine-tract binding protein (PTB) in a tissue sample obtained from the subject. An elevated level of PTB in the sample comparing to a normal control is indicative the subject is positively diagnosed... Agent: Polsinelli Shughart PC
20090325193 - Diagnostic test for the detection of a molecule or drug in whole blood: The invention provides methods of preparing a test sample for use in an assay for detecting an analyte bound by an intracellular ligand. The methods typically involve contacting the test sample with an assay reagent comprising: a lysis reagent; and a protease that has proteolytic activity for said intracellular ligand;... Agent: Paul D. Yasger Abbott Laboratories
20090325203 - Assay for tissue factor and factor vlla: The invention provides assays for detecting and quantitating tissue factor and factor VIIa in simple and complex biological systems. The assays are performed by detecting and/or measuring the tissue factor cofactor activity and factor VIIa enzymatic activity using aminonaphthalene-based fluorogenic substrates.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090325195 - Polyclonal-monoclonal elisa assay for detecting n-terminus pro-bnp: A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20090325194 - Use of spla2 activity for the diagnosis of a cardiovascular event: A method for determining an increased risk of mortality or of a cardiac and/or vascular event in a patient, includes:—determining the sPLA2 activity of the patient as a first risk marker—determining at least the value of a second risk marker chosen among CRP level, IgM IC of apo B 100... Agent: Young & Thompson
20090325204 - Compounds and methods for diagnosis and treatment of chagas disease: Compounds and methods are provided herein that provide for diagnosis and treatment of Chagas disease.... Agent: Dylan O. Adams Graybeal Jackson LLP
20090325205 - Method for measuring analysis object, biosensor and measuring device: A biosensor 1 comprises a cavity 17 for holding a sample, an electrode system 14 for measuring the sample concentration in the cavity 17, and a thermocouple 16 for obtaining temperature information during measurement. A measurement device 2 comprises a reference temperature junction sensor 33 or an environmental temperature sensor... Agent: Wenderoth, Lind & Ponack L.L.P.
20090325206 - Method for assaying the activity of lysosomal enzymes: A method, and associated kit, for assaying the activity of lysosomal enzymes present in dried bodily fluids and cell tissue samples, such as α-L-iduronidase, β-D-galactosidase, β-D-glucosidase, chitotriosidase, total α-D-galactosidase and α-D-galactosidase A, hexosaminidase A and B, α-D-mannosidase, β-D-mannosidase, α-L-fucosidase, N-acetyl-α-galactosaminidase, arylsulfatases, sphingomyelinase, β-galactocerebrosidase, iduronate-2-sulfatase and β-D-glucuronidase. The method includes: (a)... Agent: Bacon & Thomas, PLLC
20090325207 - Novel phosphodiesterase and gene thereof: The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO: 2, SEQ.ID.NO: 4, SEQ.ID.NO: 6 or SEQ.ID.NO: 39, and (B) a... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090325208 - Biosynthesis of salinosporamide a and analogs and methods thereof: The present invention relates to a sahnosporamide A composition and methods of making salinosporamide A and analogs thereof. The present invention also relates to methods of identifying 2OS proteasome inhibiting agents.... Agent: Dla Piper LLP (us)
20090325209 - Method and reagent for measuring nitroreductase enzyme activity: e
20090325215 - Cellomics system: In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction... Agent: Antonelli, Terry, Stout & Kraus, LLP
20090325210 - Counting bacteria and determining their susceptibility to antibiotics: A method for detecting and counting particles suspended in fluids, such as bacteria suspended in urine, utilizing dynamic features of the suspended particles and employing light scattering measurements. The disclosed method is suitable for determining the susceptibility of bacteria to antibiotics. A cuvette for detecting bacteria in fluids, which is... Agent: Avia Kafri
20090325212 - Data standard for biomaterials: Provided are systems and/or methods that facilitate sensing, detecting, logging, or treatment of a condition or need of a living body using a genetically engineered organism and a data standard.... Agent: Lee & Hayes, PLLC
20090325213 - Diagnostic and therapeutic application of ctl and nk functionally selected cells: The invention proposes a novel therapeutic and diagnostic methodology based on the use of effector cells (for example CTL and NK cells) selected for being able to induce lysis in target cells. In particular, the invention teaches how to select strains of effector cells of the immune system according to... Agent: Venable LLP
20090325217 - Method and apparatus for sorting cells: A method, apparatus, and system for a sorting flow cytometer include an objective lens having an optical axis coaxially aligned with the flow path at the focal point. A controllable energy source selectively alters an analyte according to a determination of whether the analyte is in a desired sub-population. In... Agent: Marshall, Gerstein & Borun LLP
20090325214 - Nuclear matrix protein alterations associated with colon cancer and their use as markers for colorectal cancer: CCSA-2 levels in serum samples from individuals suffering from colorectal cancer can be used gauging the progression of a colorectal cancer condition. In particular, the progression of a colorectal cancer condition is gauged by comparing the level of serum CCSA-2 from individuals having colorectal cancer to predetermined CCSA-2 levels that... Agent: Foley And Lardner LLP Suite 500
20090325216 - Process for the preparation of multicellular spheroids: The invention pertains to a process for the preparation of multicellular spheroids from a suspension of single cells, wherein the cells are directly derived from a biological tissue and/or from cell-containing bodily fluid. The invention is further directed to the multicellular spheroids obtained by the process according to the invention... Agent: Ratnerprestia
20090325211 - System and method for dual-detection of a cellular response: A system and method as defined herein for dual-detection of evanescent-wave label-free light and evanescent-wave excited-fluorescent label-emitted light in an optical biosensor.... Agent: Corning Incorporated
20090325219 - Device, system and assay for measuring cell motility: The present application relates to a device and system for measuring cell motility comprising a supporting substrate which includes at least one cell receiving zone and an agent receiving matrix provided on a matrix receiving zone, wherein interposed between the cell receiving zone and the agent receiving matrix is a... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20090325220 - Methods and apparatus for sterility testing: Methods and apparatus for testing the sterility of a product to be administered to a patient. The sterility of the product is tested by monitoring the pH change of a culture medium in contact with any culturable organisms (e.g., bacteria) that are collected by filtration of the product to be... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20090325221 - Temporary tattoo decals for detecting the presence of an analyte: Temporary tattoos to be applied to the skin of a wearer for the detection of an analyte are generally disclosed. The temporary tattoo can be applied to the skin via a temporary tattoo decal. The temporary tattoo can indicate the presence of an analyte by displaying a certain spectral response... Agent: Dority & Manning, P.A.
20090325223 - Magnetic immunohistochemical staining device and methods of use: The subject invention concerns a device for use in staining samples or tissues of interests on slides. The subject invention also concerns methods of using the device to stain a specimen on a slide or to detect antibody and proteins of interest of a tissue section.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090325222 - Tissue sample preparation and maldi ms imaging thereof: Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20090325224 - Process for preparation of optically active n-protected 3-aminopyrrolidine or optically active n-protected 3-aminopiperidine and the corresponding ketones by optical resolution of the racemic amine mixtures employing a bacterial omega-transaminase: The present invention relates to the production of optically active amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.... Agent: Harness, Dickey & Pierce, P.L.C
20090325225 - Method for the production of (4s)-3,4-dihydroxy-2,6,6-trimethyl-cyclohex-2-enone and derivatives thereof: The present invention relates to a method for preparing optically active (4S)-4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-one derivatives of the formula (I) and a method for preparing (3S,3′S)-astaxanthin of the formula (III) comprising the first-mentioned method.... Agent: Connolly Bove Lodge & Hutz, LLP
20090325227 - C-terminus modification method, c-terminus immobilization method and analysis method for protein or peptide: The present invention provides a method for inexpensively, easily and efficiently modifying the C-terminus of a protein or peptide; a method for easily and reliably isolating a C-terminal peptide fragment of a protein or peptide; and a method for rapidly, accurately and reliably determining an amino acid sequence of a... Agent: Cheng Law Group, PLLC
20090325228 - Fungal cell wall synthesis gene: A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these... Agent: Townsend And Townsend And Crew, LLP
20090325226 - Methods and compositions for producing active vitamin k-dependent proteins: The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying... Agent: Myers Bigel Sibley & Sajovec
20090325229 - Process for globular adiponectin production: This invention relates to methods for use in industrial production of recombinant globular Adiponectin (gAdiponectin). Specifically, the present invention provides a purification process suitable for production of high amounts of pure gAdiponectin. gAdiponectin is expressed in E. coli, and a purification method with which about 30 grams of gAdiponectin could... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090325230 - Protein expression systems: The present invention provides an improved expression system for the production of recombinant polypeptides utilizing auxotrophic selectable markers. In addition, the present invention provides improved recombinant protein production in host cells through the improved regulation of expression.... Agent: Alston & Bird LLP Dow Global Technologies, Inc.
20090325231 - Thermostable l-ribose isomerase and method for producing same and use of same: Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45° C., optimal pH of pH 9.0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45° C. during thermal treatment at pH 9.0 for 10 minutes, and with an action to... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20090325232 - Methods for prenatal diagnosis of chromosomal abnormalities: Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The invention exploits the differences in DNA between the mother and fetus,... Agent: Ronald I. Eisenstein
20090325233 - Method of producing a nucleic acid: The present invention provides a method of producing a nucleic acid at high reaction efficiency and high reproducibility with a decreased variation in yield and purity among different reaction lots. A nucleic acid synthesis reaction is carried out on a first solid phase carrier capable of supporting nucleic acid synthesis... Agent: Leydig Voit & Mayer, Ltd
20090325234 - Apparatus and method for a continuous rapid thermal cycle system: A thermal cycle system and method suitable for mass production of DNA comprising a temperature control body having at least two sectors. Each sector has at least one heater, cooler, or other means for changing temperature. A path traverses the sectors in a cyclical fashion. In use, a piece of... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090325237 - Method of analyzing a brca2 gene in a human subject: Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2(omi 1-5) and the ten polymorphic sites will provide greater accuracy and reliability for genetic testing. One skilled... Agent: Morgan Lewis & Bockius LLP
20090325238 - Method of analyzing a brca2 gene in a human subject: Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2(omi 1-5) and the ten polymorphic sites will provide greater accuracy and reliability for genetic testing. One skilled... Agent: Morgan Lewis & Bockius LLP
20090325239 - Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids: A method of juxtaposing sequence tags (GVTs) that are unique positional markers along the length of a population of target nucleic acid molecules is provided, the method comprising: fragmenting the target nucleic acid molecule to form target DNA insert; ligating the target DNA insert to a DNA vector or backbone... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090325236 - Optical sorting method: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which... Agent: Edwards Angell Palmer & Dodge LLP
20090325235 - Thermoactive sivagm sab reverse transcriptase: Methods and kits performing reverse transcription and RT-PCR reactions having high fidelity, processivity and DNA polymerase activity are described. The methods involve performance of reverse transcription at an increased temperature with a reverse transcriptase from Simian Immunodeficiency Virus-agm.sab or a variation thereof. The kits of the present invention include a... Agent: Blank Rome LLP
20090325240 - Production and use of plant degrading materials: Disclosed herein are materials useful for degrading plant biomass material. In exemplary embodiments, the plant material comprises one or more enzymes that are expressed in plants and/or bacteria. Specifically exemplified herein are plant degrading enzymes expressed in chloroplasts. The chloroplast expressed enzymes may be provided as cocktails for use in... Agent: Timothy H. Van Dyke Beusse Wolter Sanks Mora & Maire, P.A.
20090325241 - Sugar transport sequences, yeast strains having improved sugar uptake, and methods of use: Disclosed are nucleic acid constructs comprising coding sequences operably linked to a promoter not natively associated with the coding sequence. The coding sequences encode Pichia stipitis proteins that allow recombinant strains of Saccharomyces cerevisiae expressing the protein to grow on xylose, and allow or increase uptake of xylose by Pichia... Agent: Michael Best & Friedrich LLP
20090325242 - Alleles of the zwf gene from coryneform bacteria: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 184.108.40.206), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.... Agent: Law Office Of Michael A. Sanzo, LLC
20090325243 - Method for producing amino acids using glycerol: The present invention relates to an amino acid-producing microorganism capable of simultaneously utilizing glycerol as a carbon source, a method for preparing the microorganism, and a method for producing amino acids using the microorganism. According to the present invention, amino acids can be efficiently produced using a byproduct of biodiesel... Agent: Edwards Angell Palmer & Dodge LLP
20090325244 - Method of increasing gene expression using modified codon usage: The present invention relates to a method of increasing the amount of at least one polypeptide in the host cell by expressing a modified nucleotide sequence encoding for a polypeptide in a host cell with said modified nucleotide sequence being derived from a different non-modified nucleotide sequence encoding for a... Agent: Connolly Bove Lodge & Hutz, LLP
20090325245 - Ethanolamine production by fermentation: The present invention provides a bacterium and a method for the biological production of ethanolamine from a fermentable carbon source. In one aspect of the present invention, a process for the conversion of glucose to ethanolamine is achieved by the use of a recombinant bacterium transformed i) to express a... Agent: Bozicevic, Field & Francis LLP
20090325246 - Process for production of betaine: e
20090325247 - Methods for producing ceramide using transformed yeast:
20090325248 - Microbiological production of 3-hydroxypropionic acid: The invention also relates to methods for producing a genetically modified cell, to the genetically modified cells obtainable by this method, to methods for producing 3-hydroxypropionic acid, to a method for producing acrylic acid, to a method for producing polyacrylates, to a method for producing acrylic esters, and to the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090325249 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.
20090325250 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.
20090325251 - Methods and systems for biomass conversion to carboxylic acids and alcohols: The disclosure includes a method, process and apparatus for the conversion of biomass to carboxylic acids and/or primary alcohols. The system may include a pretreatment/fermentation subsystem operable to produce a fermentation broth containing carboxylic acid salts from biomass, such as lignocellulosic biomass. The system may also include a dewatering subsystem... Agent: Baker Botts L.L.P.
20090325252 - Process of treating cellulosic biomass material to produce ethanol: This invention relates to a process of treating a cellulosic biomass material to produce ethanol, at atmospheric temperatures and pressures. This process does not utilize high pressures or temperatures. The process includes the steps of: (a) exposing the cellulosic biomass material to acetic acid [C2H4O2] for 1-2 days, to produce... Agent: Donald L. Law
20090325253 - Methods and systems for production of biofuels and bioenergy products from sewage sludge, including recalcitrant sludge: The present invention provides methods and systems (SLUDFUEL system) for producing biofuel and bioenergy products using, as starting raw material, municipal, industrial, and/or farm sewage sludge, including recalcitrant sludge containing high concentrations of heavy metals, and produced after waste treatment. In accordance with the invention, municipal, industrial, and farm sewage... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090325254 - Highly active xylose reductase from neurospora crassa: A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in E. coli as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficiency, high stability at room temperature, broad pH profile, and a... Agent: Barnes & Thornburg LLP
20090325255 - Process for over-production of hydrogen: The present invention provides a process of increasing production of hydrogen during fermentation process and also an electro-biochemical is designed to achieve higher hydrogen production.... Agent: Banner & Witcoff, Ltd.
20090325256 - Method for cell patterning: introducing a cell suspension containing cells into a region between the electrode substrate and the cell culture substrate; applying a voltage to the electrodes to generate a non-uniform electric field in the region; and arranging the cells at a position with low electric field strength on the cell culture substrate... Agent: Oliff & Berridge, PLC
20090325257 - Method for influencing living cells through cell-surface interaction: The invention relates to a method for influencing living cells through cell-surface interaction where, for the cell-surface interaction, bioactive material is applied to magnetic carrier material, then this magnetic carrier material is applied to a magnetic carrier substrate, and this carrier substrate is combined with the living cells. The magnetic... Agent: Law Offices Of James E. Walton, PLLC
20090325260 - Cis reactive oxygen quenchers integrated into linkers: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.... Agent: Morgan, Lewis & Bockius LLP (sf)
20090325258 - Magnetic particle holding carrier and method for preparing the same: Provided is a magnetic particle holding carrier enabling automatization of treatment of a biological substance such as a protein by improving dispersibility of nano-size magnetic particles and suppressing nonspecific adsorption onto the wall of a container such as a pipette tip without damaging the properties of the nano-size magnetic particles... Agent: Haynes And Boone, LLPIPSection
20090325259 - Use of adhesion molecules as bond stress-enhanced nanoscale binding switches: Methods, compositions and devices are provided based on changing the binding strength of an adhesion molecule to a ligand by changing the force exerted on the bound complex between adhesion molecule and ligand, for example by changing the shear stress acting on the complex. The adhesion molecules and their ligands... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20090325262 - Immobilization of biological molecules onto surfaces coated with monolayers: The present invention provides an article for immobilizing functional organic biomolecules through a covalent bond to a thiolate monolayer on a coinage metal surface. Also provided are methods for making the article and method for the immobilization of functional organic biomolecules on the article. The thiolate monolayer contains two moieties,... Agent: Kenyon & Kenyon LLP
20090325261 - Passivation of nerve agents by surface modified enzymes stabilized by non-covalent immobilization on robust, stable particles: Enzymes are modified by incorporating anchor sites for linking the enzymes to a target surface without destroying the catalytic activity of the enzymes. A stable carrier to accommodate and bind the selected enzyme is constructed, and the enzyme is non-covalently liked to the carrier, generally through metal salts of iminodiacetate... Agent: Naval Research Laboratory Associate Counsel (patents)
20090325263 - Preparation of glassified biological reagents: The invention related to a method of making a dried reagent preparation, comprising the steps of: providing an aqueous solution of at least one buffered biological reagent; mixing a glass forming filler material with the buffered reagent solution to form a mixture wherein the concentration of the filler material is... Agent: Ge Healthcare Bio-sciences Corp. Patent Department
20090325264 - Engineered delta-15-fatty acid desaturases: The present invention provides engineered fatty acid desaturase molecules preferring Gamma Linolenic Acid (GLA) over Linoleic Acid (LA) as a substrate. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds comprising the desaturase molecule, and methods for preparing and using the same. In particular, the... Agent: Monsanto Company
20090325265 - High eicosapentaenoic acid producing strains of yarrowia lipolytica: Lysophosphatidic acid acyltransferase [“LPAAT”] participates in the second step of oil biosynthesis and is expected to play a key role in altering the quantity of long-chain polyunsaturated fatty acids [“LC-PUFAs”] produced in oils of oleaginous organisms. An LPAAT isolated from Mortierella alpina [“MaLPAAT1”] that is suitable for use in the... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090325266 - Production of peracids using an enzyme having perhydrolysis activity: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.
20090325267 - Modified xylanases exhibiting increased thermophilicity and alkalophilicity: The present invention pertains to modified xylanase enzymes that exhibit increased thermostability and alkalophilicity, when compared with their native counterparts. Several modified xylanases exhibiting these properties are disclosed including xylanases with at least one modification at amino acid position 10, 27, 29, 75, 104, 105, 125, 129, 132, 135, 144,... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090325268 - Proline-specific proteases free from amylolytic activities: The invention relates to a proline-specific protease preparation free from amylolytic activity and a purification method for obtaining the enzyme preparation according to the invention.... Agent: Nixon & Vanderhye, PC
20090325269 - Bacteria/rna extraction device: Apparatus and method for collection of a target material from a liquid sample comprising target species that contain the target material. The apparatus comprises a fluid flow conduit in communication with a filter medium having a pore size adapted to retain target species thereon and pass, as filtrate, lysate containing... Agent: Wegman, Hessler & Vanderburg
20090325270 - Use of 2-hydroxy-5-oxoproline in conjunction with algae: Provided herein are exemplary methods for the use of 2-hydroxy-5-oxoproline in conjunction with algae. One exemplary method includes applying an effective amount of 2-hydroxy-5-oxoproline to algae in an aqueous environment to accelerate creation of a high-cell density of the algae. The effective amount of the 2-hydroxy-5-oxoproline may be approximately 0.1... Agent: Carr & Ferrell LLP
20090325271 - Method for bio-assisted treatment of hydrocarbon contaminated soil: Disclosed herein is a bio-assisted method for treatment of hydrocarbon contaminated soil employing novel microbes which are capable of decontaminating hydrocarbon contaminated soil having free flowing water or in slurry form or having large amount of gravels. The method comprises adding hydrocarbon releasing microbes followed by adding the microbes capable... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090325272 - Nucleic acid sample preparation by exclusion of dna: Devices and methods are provided for separation of nucleic acids from waste materials in a biological sample, and then reacting the separated nucleic acids. In some embodiments, the methods comprise mixing a cell lysate having nucleic acids and waste materials with a waste-binding matrix to capture the cellular waste materials... Agent: Life Technologies Corporation C/o Intellevate
20090325273 - Multi-functional treating device for treating pathological tissue sections: A multi-functional treating device for pathological tissue sections includes a main body provided with at least one accommodating chamber formed in its top portion and a central controller. A water bath, an oven, a paraffin scrubber and a section baking rack are respectively installed in each of the accommodating chambers.... Agent: Sinorica, LLC
20090325274 - Analyzer: An analyzer comprising: a first specimen holder configured to hold a plurality of first specimen containers; a conveying assembly for conveying the first specimen containers held in the first specimen holder; a second specimen holder arranged at a position higher than an upper end of the first specimen containers held... Agent: Brinks Hofer Gilson & Lione
20090325275 - Cell manipulation and cultivation equipments for the production of cell therapy products: Cell manipulation and cultivation equipment for the production of cell therapy products has developed for preventing contamination of cells and improving the utility of a space. The equipment includes a room for the production and testing of cell therapy products, the room having an inner space enclosed in all sides... Agent: Gwips Peter T. Kwon
20090325276 - Integrated microfluidic assay devices and methods: Combinations of microfluidic diagnostic testing modules for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in... Agent: Seed Intellectual Property Law Group PLLC
20090325278 - Reaction system for performing in the amplification of nucleic acids: A method of carrying out an amplification reaction, said method comprising supplying to a well in a disposable unit (a) a sample which contains or is suspected of containing a target nucleic acid sequence (b) primers, nucleotides and enzymes required to effect said amplification reaction and (c) a buffer system,... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP
20090325277 - Thermal device, system, and method, for fluid processing device: A device, system, and method are provided for thermally treating a fluid processing device. According to various embodiments, a system is provided that can include a thermal device and a fluid processing device holder. The thermal device can include a first block having a thermal conductivity greater than 0.5 Watt... Agent: Life Technologies Corporation C/o Intellevate
20090325279 - Process and device for producing reagent carriers: The invention concerns a process for producing reagent carriers having a binding capability that are suitable for determining analytes in liquids, wherein the process comprises at least one step of treating a respective reagent carrier body in particular by transferring material between a treatment device and the reagent carrier body... Agent: Roche Diagnostics Operations Inc.
20090325280 - Culture observation system: There is provided a culture observation system by which even a culture other than an observation target culture can be cultured and observation can be properly performed by a microscope during culturing of the culture. A culture observation system S includes a culturing cabinet 2 for forming an environment suitable... Agent: Kratz, Quintos & Hanson, LLP
20090325281 - Composter: A composter may include a body that is sized and configured to receive composting materials. The body, which may be constructed from blow-molded plastic, may include sides that have an inner wall, an outer wall and a hollow interior portion disposed between the inner and outer walls. The inner wall... Agent: Workman Nydegger 1000 Eagle Gate Tower
20090325282 - Vessels for mixing bioprocessing materials: A flexible vessel for mixing a bioprocessing fluid has contact points or adhesions between its front and back walls to promote and guide flow patters for mixing the contents.... Agent: Twistaferm
20090325283 - Cell deposition system: A system for depositing cells on an analysis plate, the cells being contained in a cell suspension including a fixing agent and the cells, included, for receiving the suspension, a chamber (5) which is positioned above the analysis plate and whose base is open and extends opposite a cell depositing... Agent: Young & Thompson
20090325284 - Virus purification: A process for producing a retroviral or lentiviral vector formulation comprising a filter-sterilisation step wherein the filter-sterilisation step is not the final step in the purification process.... Agent: Frommer Lawrence & Haug
20090325285 - Methods and compositions for the specific inhibition of gene expression by double-stranded rna: The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090325286 - Methods and compositions for the specific inhibition of gene expression by double-stranded rna: The invention provides compositions and methods for selectively reducing the expression of a gene product from a desired target gene, as well as treating diseases caused by expression of the gene. The method involves introducing into the environment of a cell an amount of a double-stranded RNA (dsRNA) such that... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090325287 - Methods for obtaining high viable cell density in mammalian cell culture: Methods for increasing viability in fed batch eukaryotic cell culture are disclosed.... Agent: Philip S. Johnson Johnson & Johnson
20090325288 - Method for inducing differentiation of pluripotent stem cells into cardiomyocytes: A method for inducing differentiation of cardiomyocytes from pluripotent stem cells, which comprises: (i) culturing the pluripotent stem cells in a culture medium containing no substance that promotes activation of the canonical Wnt signaling pathway during the time period between initiation of differentiation induction and 24 hours before the period... Agent: Drinker Biddle & Reath (dc)
20090325289 - Process for the multiplication of stem cells: The use of a cellular development inhibitor in a controlled manner in order to maintain an undifferentiated stem cell state, especially one of human stem cells, whereby cell division is permitted.... Agent: Young & Thompson
20090325290 - Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells: The present invention relates to polypeptide compositions which bind to cell surface epitopes and, in multivalent forms, cause or lead to the killing of cells including lymphoid tumor cells, and in the case of monovalent forms, cause immunosuppression or otherwise inhibit activation of lymphocytes. The invention further relates to nucleic... Agent: Leon R. Yankwich
20090325292 - Functional polyglycolide nanoparticles derived from unimolecular micelles: Poly(glycolide) polymers are disclosed. The polymers generally include a glycolide-based polymer backbone that includes one or more functional groups such as alkynyl groups, hydrophilic organic triazole groups, hydrophobic organic triazole groups (also including amphiphilic organic triazole groups), di-triazole organic crosslinking groups, and triazole-substituted drug derivatives. The alkynyl groups provide reactive... Agent: Ian C. Mcleod Ian C. Mcleod, P.C.
20090325291 - Method of preparing sirnas for selective inhibition of target mrna isotypes: A method of preparing siRNAs for selective inhibition of target mRNA isotypes comprises: dividing target mRNA isotypes intended to inhibit the expression thereof and non-target mRNA isotypes from the mRNA isotypes of a gene; allotting a common location information region (A) of exons on genome DNA corresponding to the target... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090325295 - In-vitro mechanical loading of musculoskeletal tissues: Musculoskeletal tissues produced in vitro are optimized in response to an externally applied mechanical load. The load applied may vary from tissue to tissue, depending upon the response desired, and may include intermittent axial, torsional, and bending loads to produce cortical structures. Compression alone is preferably applied to produce cancellous... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c
20090325294 - Single pluripotent stem cell culture: The present invention relates to the field of pluripotent stem cell culture and methods facilitate pluripotent stem cell culture at industrial levels.... Agent: Philip S. Johnson Johnson & Johnson
20090325293 - Treatment of pluripotent cells: The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity.... Agent: Philip S. Johnson Johnson & Johnson
20090325296 - Electrospun electroactive polymers for regenerative medicine applications: Due to the size and complexity of tissues such as the spinal cord and articular cartilage, specialized constructs incorporating cells as well as smart materials may be a promising strategy for achieving functional recovery. Aspects of the present invention describe the use of an electroactive, or piezoelectric, material that will... Agent: New Jersey Institute Of Technology
20090325297 - Method for inhibiting expression of a protein in a hepatocyte: A method of screening a candidate compound for susceptibility to biliary excretion by a hepatocyte transport protein. The method includes the steps of providing a culture of hepatocytes comprising a transport protein, the culture having at least one bile canaliculus; exposing a candidate compound to the culture; and determining an... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20090325298 - Pro-apoptotic bacteria and compositions for delivery and expression of antigens: Whole-cell vaccines and methods for enhancing the immunogenicity of cellular microorganisms for use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria or for use as vectors to express exogenous antigens and induce responses against other infectious agents or cancer cells. The present invention involves an... Agent: Ballard Spahr LLP12/24/2009 > patent applications in patent subcategories.
20090317787 - Method for creating perfusable microvessel systems: Creating a tissue structure in vitro includes juxtaposing mandrels on a culture/perfusion device frame where the mandrels are spaced apart substantially parallel to each other and connecting the mandrels to tubes including an upstream tubes and downstream tubes. The upstream tubes are connected with an upstream manifold and the downstream... Agent: George A Leone, Sr Citadel Patent Law
20090317789 - Method for quantifying a cell population of interest contained in a human blood sample: The present invention provides to a method for quantifying a cell population of interest contained in a human blood sample, comprising the steps of: contacting a sample of human blood with a cocktail comprising a first component, comprising at least one non-human antibody, antibody fragment or derivative thereof, capable of... Agent: Darby & Darby P.C.
20090317790 - Method for the production of frozen blood or frozen blood cells for biological assays: The present invention relates to an improved method for cryo-preservation of human whole blood containing monocytes and lymphocytes at temperatures of between −40° C. and −60° C., preferably at −60° C., whereby the function of monocytes and lymphocytes is preserved. The present invention, particularly relates to a method for cryo-preservation... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090317788 - Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof: The present invention discloses a method of evaluating the status of a stem cell preparation comprising the step of detecting the presence of a glycan structure or a group of glycan structures in said preparation. The detection step can be performed by the use of a lectin specific to a... Agent: Birch Stewart Kolasch & Birch
20090317791 - Methods and apparatus for performing retention-time matching: A method (100) for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each includes potions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions (110, and associating precursor ions observed via LC/MS with their corresponding... Agent: Waters Technologies Corporation C/o Waters Corporation
20090317793 - Microfluidic device and a microfluidic system and a method of performing a test: A microfluidic device comprising at least one test channel, which test channel comprises an upper test channel section with an upstream end and a sampling region at its upstream end and at least one reference channel, which reference channel comprises an upper reference channel section with an upstream end and... Agent: Buchanan, Ingersoll & Rooney PC
20090317792 - Oil emulsions and methods for manufacture and use thereof: The invention provides oil emulsion droplets and a general and facile method for providing same through the use of templating multilayer capsules. The oil emulsion droplets are further useful in fabricating liquid crystal droplet-based biosensors for the detection of target analytes such as bacteria or viruses in a sample.... Agent: Quarles & Brady LLP
20090317794 - Biological indicator: A kinase is used in a biological indicator for validation of treatment processes designed to reduce the amount or activity of a biological agent in a sample. The indication can be used for validation of sterilisation treatment. The formation of ATP from a substrate comprising ADP is measured via the... Agent: Evan Law Group LLC
20090317796 - Indirect immunofluorescence assay typing kit for coxsackievirus a group and method for typing coxsackievirus a group: An indirect immunofluorescence assay typing kit for coxsackievirus, comprising: a first reagent comprising a mixture of an anti-coxsackievirus A2 polyclonal antibody, an anti-coxsackievirus A4 polyclonal antibody, an anti-coxsackievirus A5 polyclonal antibody, an anti-coxsackievirus A6 polyclonal antibody, and an anti-coxsackievirus A10 polyclonal antibody; a second reagent comprising the anti-coxsackievirus A2 polyclonal... Agent: Muncy, Geissler, Olds & Lowe, PLLC
20090317795 - Method of detecting h5 or h7 avian influenza virus: The present invention provides oligonucleotide primers specifically hybridizing to an arbitrary nucleotide sequence designed from the nucleotide sequence of hemagglutinin of an H5 or H7 avian influenza virus, a nucleic acid amplification method using the primers, a method for diagnosis of infection with an H5 or H7 avian influenza virus... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090317798 - Analysis using microfluidic partitioning devices: The invention relates to methods, reagents and devices for detection and characterization of nucleic acids, cells, and other biological samples. Assay method are provided in which a sample is partitioned into sub-samples, and analysis of the contents of the sub-samples carried out. The invention also provides microfluidic devices for conducting... Agent: Townsend And Townsend And Crew, LLP
20090317802 - Compositions and methods to monitor rna delivery to cells: Methods and compositions for tracking or monitoring uptake of siRNA by mammalian cells are provided. The methods and compositions may be used to monitoring the silencing activity of the internalized siRNA. The compositions contain an siRNA, an optically or magnetically detectable nanoparticle such as a quantum dot and, optionally, a... Agent: Choate, Hall & Stewart LLP
20090317803 - Enzymatic time-resolved luminescent assay for nucleic acids quantitation: The objects of the present invention are to provide a new technology platform for quantitation number of copies of nucleic acid molecules of interest by lumonogenic (i.e., enzymatic luminescence) detection. The detection approach of the method of present invention is essentially employing time-resolved approach, e.g., based on detection transient parameters... Agent: Valeri Golovlev
20090317824 - Fluid processing device comprising radial channels: The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i)... Agent: Life Technologies Corporation C/o Intellevate
20090317812 - Method of detecting preeclampsia: The invention provides a method for detecting a propensity toward or risk of developing preeclampsia, comprising detecting in a female subject the presence of a single base pair point mutation, ΔA at position +1754, in the HLA-G mRNA 3′UTR. The mutation is associated with preeclampsic subjects, and with decreased RNA... Agent: Mathews, Shepherd, Mckay, & Bruneau, P.A.
20090317813 - Method of predicting metastasis of oral cavity cancer into cervical lymph node and diagnosis kit to be used in the prediction: A method for objectively predicting possibility of metastasis to a cervical lymph node in an early stage for an individual case diagnosed as an oral cavity cancer, and a diagnosis kit to be used in the prediction are provided. The method includes a step of assaying expression amounts of metastasis... Agent: Squire, Sanders & Dempsey L.L.P.
20090317801 - Methods and compositions for disease prognosis based on nucleic acid methylation: A large scale DNA methylation study was performed in patients with acute myeloid leukemia (AML) that revealed quantitative methylation patterns correlated with patient survival. Based on these results, a prognostic model was built which categorizes a patient's risk—either in a good or poor prognosis group. The findings provided herein support... Agent: Grant Anderson LLP C/o Portfolioip
20090317821 - Methods and compositions for identifying individuals at reduced risk of sepsis: The present invention provides a method of identifying a subject having a reduced risk of developing sepsis, comprising detecting at least one APOE3 allele in nucleic acid from the subject.... Agent: Myers Bigel Sibley & Sajovec
20090317810 - Methods and nucleic acids for the detection of colorectal cell proliferative disorders: The invention provides methods, nucleic acids and kits for detecting, or for distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and... Agent: Davis Wright Tremaine, LLP/seattle
20090317816 - Methods for identifying risk of breast cancer and treatments thereof: Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments... Agent: Grant Anderson LLP C/o Portfolioip
20090317804 - Methods of determining antibiotic resistance: This disclosure relates to methods of determining an antibiotic resistance profile of a bacterium, and methods of treating a patient with a therapeutically effective antibiotic. The methods include comparing the restriction map of the nucleic acid with a restriction map database, and determining antibiotic resistance of the bacterium by matching... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090317820 - Micro-rna profile in human saliva and its use for detection of oral cancer: The present invention provides for the first time the detection of micro-RNA in human saliva and the correlation between such micro-RNA and oral cancers. The present invention therefore provides methods and kits for diagnosing oral cancers by examining pertinent micro-RNA in saliva.... Agent: Townsend And Townsend And Crew, LLP
20090317814 - Mitochondrion-bound nucleic acid for determining a health status of an individual: The invention describes means and methods for determining mitochondrion-bound nucleic acid and describes the use thereof in diagnostics. Preferable cell-free mitochondrion-bound nucleic acid is determined.... Agent: Traskbritt, P.C.
20090317815 - Mononucleotide repeats microsatellite markers for detecting microsatellite instability: A method for evaluating microsatellite instability associated with a tumour, which entails the steps of amplifying microsatellite loci in a biological sample containing genomic DNA from the tumour and determining sizes of DNA amplification products, wherein at least one microsatellite locus selected from the group consisting of NR 21, NR... Agent: The Nath Law Group
20090317823 - Mutations in capillary morphogenesis gene-2 (cmg-2) and use thereof: Mutations and polymorphisms in a particular gene, the capillary morphogenesis gene-2 (CMG-2) have been identified. The mutations have been associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF), as well as conditions associated with these disorders. Described herein are variant CMG-2 nucleic acids and variant CMG-2 polypeptides; cells... Agent: Darby & Darby P.C.
20090317797 - Non-invasive, prenatal, in-vitro method for detecting the normal healthy condition, the condition of a healthy carrier or the condition of a carrier inflicted with cystic fibrosis: The invention relates to a non-invasive, prenatal, in-vitro method for detecting the normal healthy condition, the condition of a healthy carrier or the condition of a carrier inflicted with cystic fibrosis, from the fetal cell(s) from a maternal sample, comprising the DNA of an individual to be tested. The invention... Agent: Nixon & Vanderhye, PC
20090317808 - Novel nucleotide and amino acid sequences and methods of use thereof for diagnosis: Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.... Agent: Fennemore Craig
20090317817 - Nucleic acid-based tests for prenatal gender determination: Provided herein are compositions, processes and kits for noninvasive, early determination of fetal sex from, and/or amount of fetal nucleic acid in, an extracellular nucleic acid sample from a pregnant female. Such compositions, processes and kits are useful for detection of low genomic copy numbers of male fetal nucleic acid... Agent: Grant Anderson LLP C/o Portfolioip
20090317819 - Phospholipid oxidation and lp-pla2 as predictors of coronary artery disease: Provided herein are compositions and methods for identifying individuals at risk for developing coronary artery disease (CAD).... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP
20090317807 - Primers for use in detecting metallo-beta-lactamases: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain beta-lactamases. The primers can be employed in methods to identify nucleic acid characteristic of family-specific beta-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.... Agent: Mueting, Raasch & Gebhardt, P.A.
20090317809 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 52 to 54 or a combination of at least two of... Agent: Fitzpatrick Cella Harper & Scinto
20090317805 - Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining: The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090317800 - Reporter vector for use in evaluation of cyp1a2 induction: A reporter vector which can evaluate the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 and a method for evaluation of the ability of a drug to induce CYP1A2 or both of CYP1A1 and CYP1A2 by using the reporter vector. A reporter system which can... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090317818 - Restriction endonuclease enhanced polymorphic sequence detection: Provided in part herein is an improved method for the detection of specific polymorphic alleles in a mixed DNA population. The method comprises enriching the relative percentage of a given polymorphic allele that is exponentially amplifiable by PCR. Provided also are methods for selectively enriching target nucleic acid, for example,... Agent: Grant Anderson LLP C/o Portfolioip
20090317822 - Selection of intracellular immunoglobulins: A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This can be accomplished for many immunoglobulins expressed in yeast and/or in mammalian cells and allows the selection of immunoglobulins which are capable... Agent: Lucas & Mercanti, LLP
20090317806 - Systems and methods for monitoring the amplification of dna: A system and method for amplifying and detecting nucleic acids are disclosed. In one embodiment, the system includes: a microfluidic device comprising a channel for receiving a sample of solution containing real-time PCR reagents; a temperature control system configured to cycle the temperature of the sample; an excitation source for... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090317811 - Two pore channels as regulators of proliferation in cancer: The present invention relates to the discovery that two pore K+ channel (2PK) gene expression is increased in tumors and tumor cell lines, especially prostate tumor cells. The present invention encompasses methods for disease diagnosis, drug screening and the treatment of cancer.... Agent: Kenyon & Kenyon LLP
20090317799 - Variants at chr8q24.21 confer risk of cancer: A locus on chromosome 8q24.21 has been demonstrated to play a major role in particular forms of cancer. It has been discovered that certain markers and haplotypes are indicative of a susceptibility to particular cancers. Diagnostic applications for identifying susceptibilty to cancer are described.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20090317825 - Assay for parkinson's disease therapeutics and enzymatically active parkin preparations useful therein: The invention provides to assays for agent useful for treatment of Parkinson's Disease. Included are cell-based assays for agents that modulate the effect of Parkin proteins on proteasome function. The invention also provides recombinant, enzymatically active, Parkin protein produced in prokaryotic expression systems, such as E. coli cells. Methods for... Agent: Townsend And Townsend And Crew, LLP
20090317826 - Monoclonal antibodies and methods for their use in the detection of cervical disease: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that... Agent: Alston & Bird LLP
20090317828 - Diagnostic kits to detect sp22 and sp22 antibodies: Oral, topical and injectable contraceptives, which are based on sperm protein 22 kDa (SP22) polypeptides and antibodies and infertility diagnostics and kits are provided.... Agent: Foley Hoag, LLP Patent Group (w/isa)
20090317829 - High-throughput assay for sugar-mediated drug transport: The invention provides a rapid, quantitative assay to directly assess the impact of a diverse range of sugars upon the sugar-mediated uptake of corresponding sugar-conjugates into various cell types.... Agent: Quarles & Brady LLP
20090317827 - Receptor in dendritic cells: The present invention provides the use of GPR91 as a target in dendritic cells.... Agent: Novartis Corporate Intellectual Property
20090317832 - Cell classification system: The present invention involves the reaction of a CD4 immuno-conjugate with a sample of patient whole blood. The CD4 immuno-conjugate consists of one or more antibodies with specificity for the CD4 surface receptor coupled to a signal moiety, or “label”, that is detectable by a flow cytometer. Such labels may... Agent: Edwards Angell Palmer & Dodge LLP
20090317835 - Device for sampling cells by contact: A microtechnological device (6) for sampling cells on or in a tissue or other element of the body. It comprises a support (12) having at least one surface of interest (14) on which is present at least one recovery zone (10) comprised of a bottom wall (22) equipped with a... Agent: Pearne & Gordon LLP
20090317834 - Novel cellular glycan compositions: The invention describes novel compositions of glycans, glycomes, from human embryonic stem cells, and especially novel subcompositions of the glycomes with specific monosaccharide compositions and glycan structures. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore, the invention... Agent: Birch Stewart Kolasch & Birch
20090317833 - Screening method: The present invention provides a method of screening for a drug for the prophylaxis or treatment of at least one disease selected from the group consisting of cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, severe sepsis and septic shock, which includes selecting a substance... Agent: Foley And Lardner LLP Suite 500
20090317831 - Sepsis test: There is provided a method for determining whether a subject has a bacterial infection comprising: identifying an abnormal expression of one or more of CD49e, CD 14, CD11c, CD49f, and CD29 on leucocytes in a sample obtained from the subject; wherein an abnormal expression of CD49e, CD 14, CD11c, CD49f... Agent: Banner & Witcoff, Ltd.
20090317837 - Cancer diagnosis based on levels of antibodies against globo h and its fragments: A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4.... Agent: Occhiuti Rohlicek & Tsao, LLP
20090317836 - Methods for detection of circulating tumor cells and methods of diagnosis of cancer in mammalian subject: Methods are provided for detecting circulating tumor cells in a mammalian subject. Methods of diagnosing cancer in a mammalian subject are provided. The methods of detection or diagnosis indicate the presence of metastatic cancer or early stage cancer.... Agent: The Scripps Research Institute
20090317839 - Botulinum toxin screening assays: Methods for detecting BoNT/A activity in a sample, methods for screening molecules able to compete with BoNT/A receptor binding, methods for reducing BoNT/A activity in a human and methods of marketing a neurotoxin capable of selectively binding to FGFR3 to a governmental or regional regulatory authority.... Agent: Allergan, Inc.
20090317838 - Detection of bacterial peptidoglycan-like compounds: Innate immunity to bacterial pathogens relies on the detection of bacterial peptidoglycans. Intracellular NOD2 proteins sense peptidoglycans and respond by activating transcription factors. An in vitro assay utilizing a reporter gene under the control of a promoter that contains transcription recognition sequences for the binding of a transcription factor that... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090317840 - Automated determination of chlamydia infection-forming units: The present features an automated method of measuring Chlamydia infection forming units. The method employs a polypeptide recognizing Chlamydia infected inclusion body components. The polypeptide specifically binds to either, or both, a Chlamydia elementary body or reticulate body. Polypeptide binding is detected using a colorimetric indicator and an automated detector.... Agent: Merck And Co., Inc
20090317830 - Hepatitis c virus ns2/3 assay: The present invention provides an assay for the detection of the NS2/3 cleavage products NS2 or NS3 in the presence of uncleaved NS2/3. Following self-cleavage of NS2/3 to generate NS2 and NS3 cleavage products, a sample is incubated with a ligand specific for the recognition of NS2 or NS3 cleavage... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation
20090317843 - Method for measuring plasma levels of long pentraxin ptx3: The present invention relates to a method for measuring PTX3 in a biological fluid, particularly in human or animal plasma. Particularly, the present invention relates to a method for measuring PTX3 levels in a human or animal derived plasma sample, comprising a stage of the treatment of said plasma sample... Agent: Dickstein Shapiro LLP
20090317841 - Methods and materials for the detection of leishmania infection: The present invention provides rapid diagnostic assays for the detection of Leishmania which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive assays, including ELISA and lateral flow assays, employ antibodies that may be effectively employed to detect the Leishmania major antigen... Agent: Speckman Law Group PLLC
20090317842 - Methods and tools for the therapy of neurodegenerative pathologies: The present invention concerns compositions and methods for the treatment of neurodegenerative diseases in which the cognitive functions are altered, such as observed in Alzheimer's disease. More particularly, the invention presents a strategy for human clinical monitoring of the activity and/or effectiveness of neuroprotective treatments, based on biochemical assay of... Agent: Nixon & Vanderhye, PC
20090317844 - Diagnostic test for hepatocellular carcinoma: A diagnostic test for hepatocellular carcinoma is based on increases in the concentration of two biochemical markers in a biological sample, alpha-1-acid glycoprotein (AAG) or isoforms thereof and alpha-fetoprotein (AFP) or glycoforms thereof. Levels of these markers may be performed using an immunoassay. Also disclosed is a diagnostic kit for... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090317845 - Impulsive noise sensor: The present invention provides a method for measuring the presence of an analyte in a sample, wherein the presence of the analyte is indicated by the presence or absence of one or more trigger elements that generate an impulsive noise when triggered, comprising the steps of: (a) exposing the one... Agent: Nixon & Vanderhye, PC
20090317846 - Method for detection of familial combined hyperlipidemia: An object of the present invention is to provide an excellent method for detection and diagnosis of familial combined hyperlipidemia. The present invention relates to a method for detection of familial combined hyperlipidemia, comprising measuring the concentration of small, dense LDL cholesterol in a sample collected from a subject.... Agent: Foley And Lardner LLP Suite 500
20090317847 - Method for determining an analtye in a bodily fluid: A method for determining (e.g., detecting and/or measuring the concentration of) an analyte in a bodily fluid sample includes obtaining a bodily fluid sample, applying the bodily fluid sample to an analyte test strip, transferring the applied bodily fluid sample to a sample-receiving chamber of the analyte test strip, and... Agent: Philip S. Johnson Johnson & Johnson
20090317848 - Modified flavin adenine dinucleotide dependent glucose dehydrogenase: The invention provides a modified flavin adenine dinucleotide dependent glucose dehydrogenase (FADGDH), as well as a glucose sensor comprising the modified FADGDH and a method for measuring glucose comprising using the glucose sensor to measure glucose of a sample... Agent: Leydig Voit & Mayer, Ltd
20090317849 - Biochip for the detection of phosphorylation and the detection method using the same: The present invention relates to a biochip for the detection of phosphorylation and a detection method of phosphorylation using the same, more precisely a biochip prepared by integrating a recombinant fusion protein produced from the reaction of a kinase matrix selected from the group consisting of PKC (Protein Kinase C),... Agent: Lucas & Mercanti, LLP
20090317850 - Crystal structure of human 70kd ribosomal protein s6 kinase 1 kinase domain: Crystallization of the 70 kDa ribosomal protein S6 kinase polypeptide 1 (p70S6K1) kinase domain for X-ray crystallography analysis to generate the three-dimensional structure of the p70S6K1 kinase domain is described. Further described is the use of the three 5 dimensional structure of p70S6K1 kinase domain for identifying and designing ligands... Agent: Merck And Co., Inc
20090317851 - Hemoglobin a1c determination method, enzyme to be used therefor, and production method thereof: There is provided a method for specifically determining a glycated β-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor. A protease that cleaves a glycated amino acid and/or a glycated peptide from a glycated β-chain N-terminal without substantially cleaving a glycated amino... Agent: Greenblum & Bernstein, P.L.C
20090317858 - Cellular assays for signaling receptors: The present invention provides cells and methods related to signaling receptors. The cells of the invention express the signaling receptors (e.g., in a constitutively active state). The cells are useful for analyzing the signaling receptors and their related pathways. The invention further provides methods for studying interactions of the signaling... Agent: Life Technologies Corporation C/o Intellevate
20090317852 - Engineered cell growth on polymeric films and biotechnological applications thereof: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090317853 - Method for producing a layer on a molded article and use thereof: A method for producing a layer on a molded article. The method includes providing a formable film. Galvanically catalytically active nuclei are anchored to at least one region of the formable film provided for the layer. The formable film is shaped so as to form the molded article. A galvanic... Agent: Darby & Darby P.C.
20090317856 - Multimodal spectroscopic systems and methods for classifying biological tissue: Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with preset criteria configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those... Agent: Howard & Howard Attorneys PLLC
20090317855 - Receptor-mediated delivery: compositions and methods: Compositions and methods for delivering an agent to a cell comprising a prolactin receptor are provided. Also provided is a method of inhibiting a breast, ovarian or prostate cancer cell, where the method includes a step of contacting the cell with a complex comprising a prolactin receptor ligand linked to... Agent: Michael Best & Friedrich LLP
20090317854 - Recombinant adenylate cyclase of bordetella sp. for diagnostic and immunomonitoring uses, method of diagnosing or immunomonitoring using said recombinant adenylate cyclase, and kit for diagnosing or immunomonitoring comprising said recombinant adenylate c: Diagnostic testing and immunomonitoring that uses genetically detoxified Bordetella pertussis CyaA as a delivery system are effective in tracking any immune responses, such as those generated by infectious and non-infectious diseases, or vaccinations, for example. T cells previously stimulated by a given antigen can be restimulated in vitro by the... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090317857 - Transformation of algal cells: Exemplary methods include a method for transforming an algal cell by preparing a transformation construct, preparing a particle for bombarding the algal cell, adhering the transformation construct to the particle, bombarding the algal cell with the particle, and growing the algal cell into a colony. The transformation construct is replicated... Agent: Carr & Ferrell LLP
20090317859 - Calorimetric assessment of microorganisms and use thereof: Methods, integrated kits and systems for the rapid detection, identification and/or quantification of microorganisms in samples such as blood samples via calorimetry are disclosed.... Agent: Joyce Von Natzmer Pequignot + Myers LLC
20090317860 - Standard material for a particle analyzer: A standard material that is used for judging an abnormal portion in a particle analyzer is described. The standard material comprises first standard particles to be fluorescence-stained by a fluorescence-staining treatment and second standard particles that have preliminarily contained a fluorescence dye. A method and an analyzer that can judge... Agent: Sughrue Mion, PLLC
20090317861 - Cell-free synthesis of virus like particles: Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of virus like particles.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP
20090317864 - Alpha-amylase mutants: The invention relates to a novel Termamyl-like alpha-amylase, and Termamyl-like alpha-amylases comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence... Agent: Novozymes North America, Inc.
20090317862 - Cell-free protein synthesis system for synthesizing glycoprotein: Provided is a process for producing a protein with post-translational modification in a cell-free protein synthesis system having a higher protein synthetic activity and glycosylation capability. The process of the present invention comprises preparing a cell extract from cultured cells of an immortalized mammalian cell line that has enhanced protein... Agent: Birch Stewart Kolasch & Birch
20090317865 - Eubacterial rna-polymerase mutants with altered product production: The present invention relates to an isolated mutant eubacterium comprising at least one mutation resulting in a substitution of at least one amino acid in the beta-subunit of the RNA-polymerase encoded for by the rpoB-gene providing an altered production of a product of interest when said production of a product... Agent: Novozymes North America, Inc.
20090317863 - Use of active cytokinin synthase gene: (d) a gene encoding a protein which consists of an amino acid sequence derived from the amino acid sequence as shown in any one of SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14 and 16 by deletion, substitution or addition of one or several amino acid residues and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090317866 - Methods for increasing expression of genes in a fungal cell: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide comprising a nucleic acid sequence encoding the polypeptide operably linked to a copper-inducible promoter... Agent: Novozymes, Inc.
20090317867 - Methods for enhanced production of bone morphogenetic proteins: Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-β superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least... Agent: Wyeth/finnegan Henderson, LLP
20090317868 - Rapidly cleavable sumo fusion protein expression system for difficult to express proteins: A recombinant expression system for the expression of a poly amino acid, peptide or protein is provided. The poly amino acid of interest is expressed as a fusion protein that includes an amino acid sequence recognized and cleaved by a Ulp1 protease. The amino acid sequence joined to the poly... Agent: Hoffmann & Baron, LLP
20090317869 - Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation: The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.... Agent: Townsend And Townsend And Crew LLP
20090317870 - Industrially useful microorganism: The present invention provides a microorganism which comprises a chromosomal DNA lacking a part or entire of the gene encoding a protein having the amino acid sequence as shown in SEQ ID NO: 1 or 2, or the gene encoding a protein having 80% or more homology with the amino... Agent: Fitzpatrick Cella Harper & Scinto
20090317871 - Bacillus licheniformis b1, alkalophilic enzyme solution and method of producing the same: The present invention relates to Bacillus licheniformis B1 strain, alkalophilic enzyme solution and a method for preparing the same, in particular the method for producing cellulase demonstrating optimal activity at pH 10-13 by using Bacillus licheniformis B1 strain. The enzyme produced by the method of the present invention and the... Agent: Larson And Larson
20090317872 - Acid fungal protease in fermentation of insoluble starch substrates: The invention is directed to methods of producing ethanol and decreasing residual starch production in a no cook fermentation comprising contacting granular starch containing substrates with a granular starch hydrolyzing enzyme, a protease, and a fermenting microorganism under suitable fermentation conditions at a temperature below the starch gelatinization temperature of... Agent: Danisco US Inc. Attention: Legal Department
20090317873 - Design, synthesis and assembly of synthetic nucleic acids: Methods of synthesizing oligonucleotides with high coupling efficiency (>99.5%) are provided. Methods for purification of synthetic oligonucleotides are also provided. Instrumentation configurations for oligonucleotide synthesis are also provided. Methods of designing and synthesizing polynucleotides are also provided. Polynucleotide design is optimized for subsequent assembly from shorter oligonucleotides. Modifications of phosphoramidite... Agent: Jones Day
20090317874 - Systems and methods for amplifying nucleic acids: An apparatus for performing a thermocyclic process, such as amplifying DNA, includes a microfluidic chip with a channel formed therein and one or more thermal distribution elements disposed over portions of the chip. Each thermal distribution element is configured to distribute thermal energy from an external thermal energy source substantially... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090317875 - Nucleic acid cloning: The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo... Agent: Choate, Hall & Stewart LLP
20090317876 - Method for producing an l-amino acid by fermentation using a bacterium having an enhanced ability to utilize glycerol: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to have glycerol kinase in which feedback inhibition by fructose-1,6-bisphosphate is desensitized, thereby having enhanced ability to utilize glycerol.... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC
20090317877 - Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medium: The present invention relates to a method of producing secondary metabolites with a high yield using plant cell culture, and a medium for the production of secondary metabolites. More specifically, the method of the present invention is characterized in that the plant cell culture is conducted by adding a saccharide... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c
20090317878 - Nuclear based expression of genes for production of biofuels and process co-products in algae: Various embodiments provide, for example, vectors, expression cassettes, and cells useful for transgenic expression of nucleic acid sequences. In various embodiments, vectors can contain nuclear-based sequences of unicellular photosynthetic bioprocess organisms for the production of food- and feed-stuffs, oils, biofuels, starches, raw materials, pharmaceuticals or fine chemicals.... Agent: Knobbe Martens Olson & Bear LLP
20090317879 - Use of selection pressures to enable microbial biosynthesis of polyhydroxyalkanoates from anaerobic degradation products: A method for inexpensive and efficient PHA biosynthesis includes operating a sequencing bioreactor in alternating phases of nutrient deprivation and carbon feedstock deprivation to select for robust PHA-producing microbes. Preferably, the bioreactor is operated in a non-sterile manner with mixed cultures of methanotrophs. The method also preferably uses periodic biomass-wasting... Agent: Lumen Patent Firm
20090317880 - Simple, rapid method for the preparation of isotopically labeled formaldehyde: Isotopically labeled formaldehyde (*C§H2O) is prepared from labeled methyl iodide (*C§H3I) by reaction with an oxygen nucleophile having a pendant leaving group. The mild and efficient reaction conditions result in good yields of *C§H2O with little or no *C isotopic dilution. The simple, efficient production of 11CH2O is described. The... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory
20090317881 - Metabolically engineered cells for the production of pinosylvin: A genetically engineered micro-organism having an operative metabolic pathway producing cinnamoyl-CoA and producing pinosylvin therefrom by the action of a stilbene synthase is used for pinosylvin production. Said cinnamic acid may be formed from L-phenylalanine by a L-phenylalanine ammonia lyase (PAL) which is one accepting phenylalanine as a substrate and... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090317882 - Electromethanogenic reactor and processes for methane production: Increasing competition for fossil fuels, and the need to avoid release carbon dioxide from combustion of these fuels requires development of new and sustainable approaches for energy production and carbon capture. Biological processes for producing methane gas and capturing carbon from carbon dioxide are provided according to embodiments of the... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c
20090317883 - Individual-cell electroporation using area-focused electric fields: Electroporation is performed on a population of cells, liposomes, vesicles, or other membrane-encased structures with uniform results regardless of size variations within the population, by drawing the membrane-encased structures into micron-sized openings that contain paired electrodes. An electric potential is then imposed between the paired electrodes to permeabilize only that... Agent: Townsend And Townsend And Crew, LLP
20090317884 - Method and apparatus for treatment enhancement in acoustic processing of samples: Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace at a sample/gas interface. An interaction between the acoustic energy... Agent: Wolf Greenfield & Sacks, P.C.
20090317885 - Photoactive metal nitrosyls for blood pressure regulation and cancer therapy: Disclosed are nitric oxide delivery agents and methods of their use, more specifically to photoactive compounds, which are able to perform targeted delivery of nitric oxide in vitro and in vivo and are useful for medicinal applications including, but not limited, to blood pressure regulation and cancer treatment.... Agent: Peter G. Carroll Medlen & Carroll, LLP
20090317886 - Apparatus and methods for separating, concentrating and isolating algae: Apparatus and method to efficiently separate A. flos aquae from M. aeruginosa are described so that A. flos aquae may be processed for human consumption. A separation/concentration/isolation tank has a vertically oriented axis with an open top. The tank wall is at least partly transparent or translucent so that sunlight... Agent: Hancock Hughey LLP
20090317887 - Charged initiator polymers and methods of use: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.... Agent: Kagan Binder, PLLC
20090317888 - Thermus egertssonii dna polymerases: The present invention relates to a thermophilic polymerase, wherein the DNA polymerase has an in-vitro primer extension rate that is >35 bases/second and faster relative to the primer extension rate of a DNA polymerase comprising amino acid sequences SEQ ID NO: 2 or 4, when measured under identical conditions in... Agent: Ballard Spahr LLP
20090317889 - Purification of proteins with cationic surfactant: The subject invention provides a method for purifying a target protein from a mixture comprising the target protein and contaminating protein, comprising the steps of exposing the mixture to an effective amount of a cationic surfactant such that the contaminating protein is preferentially precipitated and recovering the target protein. Proteins... Agent: Kramer Levin Naftalis & Frankel LLP Intellectual Property Department
20090317890 - Fibrionolytic metalloprotease and composition comprising the same: The present invention relates to a novel protease, a polynucleotide encoding the protease, and a fibrinolytic agent comprising the same. The protease is obtained from a new gene source by using metagenomic library technology, and can replace the conventional fibrinolytic agent.... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c
20090317891 - Plant activation of insect toxin: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.
20090317892 - Enhancer of proliferation of lactic acid bacterium, and agent for improvement in survivability of lactic acid bacterium: A dead cell of a lactic acid bacterium or a culture containing the dead cell of a lactic acid bacterium is added to the dairy products such as yogurt, cheese, milk beverage or the like in an amount of 0.001 wt % or more in dry weight of the dead... Agent: Young & Thompson
20090317893 - Desizing process: A process for desizing of a sized fabric containing starch or starch derivatives during manufacture of a fabric, which process comprises incubating said sized fabric in an aqueous treating solution having a pH in the range between 1 and 5 which aqueous treating solution comprises an alpha-amylase.... Agent: Novozymes North America, Inc.
20090317894 - Cell lysis reagent for isolation of rna: RNA is extracted from cellular material with a reagent that includes heparin, a reducing agent to reduce disulfide bonds, a chelating agent, a buffer, and an alkali metal halide. The reagent does not require the use of organic solvents, and the reagent allows extraction to be performed in a relatively... Agent: Townsend And Townsend And Crew, LLP
20090317895 - Observation device: An observation device which is provided with an observation optical system and observes a specimen cultured in a culture vessel via the observation optical system includes a moving unit moving the culture vessel to a position where a distortion caused by the observation optical system occurs, an imaging unit imaging... Agent: Oliff & Berridge, PLC
20090317896 - Thin film chemical analysis apparatus and analysis method using the same: Disclosed is a thin film chemical analysis apparatus and an analysis method using the same, which can solve the sealing problem caused by environmental factors (e.g. impact, temperature) for long circulation and storage periods, as well as can detect an analyte quickly and easily. The thin film chemical analysis apparatus... Agent: Staas & Halsey LLP
20090317898 - Apparatus for determining gene polymorphism: In a preferred embodiment, a gene polymorphism diagnosing reaction vessel at least having a plurality of probe arrangement parts each individually holding a probe that emits fluorescence in accordance with each of a plurality of polymorphic sites is used. A controller (118) determines presence or absence of a gene polymorphism... Agent: Cheng Law Group, PLLC
20090317899 - Handling kit for analyzing a liquid sample by nucleic acid amplification: The invention refers to a handling kit for analyzing a liquid sample, especially by nucleic acid amplification, comprising a disposable sample holding and processing device (1) dimensioned for use in an apparatus for analyzing a liquid sample, and a sample transfer tip (12) for transferring liquid into the disposable device... Agent: Roche Molecular Systems, Inc. Patent Law Department
20090317897 - Reaction vessel, reaction measuring device, and liquid rotating treatment device: An object is to provide a reaction vessel, a reaction measuring device, and a liquid rotating treatment device wherein temperature control of a liquid stored within the vessel can be performed with a high accuracy and faithful responsiveness. The construction is such that a vessel has: a storage chamber in... Agent: Haynes And Boone, LLPIPSection
20090317900 - Chromatography device: A chromatography device includes a sample introducing portion for introducing a sample in a liquid state and provided at an upstream side of a flow of the sample, a developing means including a creatinine detecting portion, at which a creatinine detection reagent for detecting creatinine in the sample is provided,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090317901 - Fuel farm: Every generation of algae and bacteria makes new variations better able to deal with conditions and make more of what we want. Isolating superior strains is a simple, but never-ending process that is part of the Fuel Farm™ system. As well, the end-product is a wet mixture that cannot be... Agent: Adrian Vance
20090317902 - Continuous process and apparatus for enzymatic treatment of lipids: A method and system for the enzymatic treatment of a lipid containing feedstock comprises contacting the feedstock with a processing aid, then causing the feedstock to pass at a substantially constant flow rate through a treatment system comprising a plurality of enzyme-containing fixed bed reactors connected to one another in... Agent: Jones Day
20090317903 - Humanized anti-tag 72 cc49 for diagnosis and therapy of human tumors: The present disclosure provides humanized CC49 monoclonal antibodies that bind TAG-72 with high binding affinity and that are minimally immunogenic. In one embodiment, a humanized CC49 antibody includes a non-conservative amino acid substitution in a light chain complementarity determining region 3 of the CC49 antibody. In a further embodiment, the... Agent: Klarquist Sparkman, LLP
20090317904 - Vcp-based vectors for algal cell transformation: Provided herein are exemplary vectors for transforming algal cells. In exemplary embodiments, the vector comprises a Violaxanthin-chlorophyll a binding protein (Vcp) promoter driving expression of an antibiotic resistance gene in an algal cell. Embodiments of the invention may be used to introduce a gene (or genes) into the alga Nannochloropsis,... Agent: Carr & Ferrell LLP
20090317905 - Mutations in ion channel proteins associated with sudden cardiac death: Previously unknown mutations of the KCNH2, SCN5A and KCNQ1 genes are disclosed which are involved in ion channel disruptions associated with short QT syndrome, long QT syndrome, Brugada syndrome and progressive conduction disease. These mutations are utilized to diagnose and screen for short QT syndrome, long QT syndrome, Brugada syndrome... Agent: Carter, Deluca, Farrell & Schmidt, LLP
20090317906 - Gene silencing using sense dna and antisense rna hybrid constructs coupled to peptides facilitating the uptake into cells: The present invention generally relates to gene silencing using sense DNA (sDNA)-antisense RNA (aRNA) hybrids wherein the sense DNA strand is coupled to a peptide which facilitates the uptake of the hybrid into cells.... Agent: Morgan Lewis & Bockius LLP
20090317908 - Highly packed polycationic ammonium, sulfonium and phosphonium lipids: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.... Agent: Life Technologies Corporation C/o Intellevate
20090317907 - Oligomeric compounds and compositions for use in modulation of small non-coding rnas: Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment... Agent: Pepper Hamilton LLP
20090317909 - Skeletal muscle periangioblasts and cardiac mesangioblasts, method for isolation and uses thereof: The present invention discloses the isolation and characterization of cells isolated either from adult skeletal muscle or from adult cardiac muscle. These cells are used for the treatment of muscular disorders including muscular dystrophy and cardiopathics, respectively.... Agent: Kenneth Sharples
20090317910 - Multiplex automated genome engineering: The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells.... Agent: Banner & Witcoff, Ltd.
20090317911 - System and method for photodynamic cell therapy: A method for stimulating, inhibiting, or regulating gene expression including exposing a living cell with at least one gene to an administered source of narrowband, multichromatic electromagnetic radiation.... Agent: Nelson Mullins Riley & Scarborough, LLPIPDepartment12/17/2009 > patent applications in patent subcategories.
20090311662 - Method for harvesting and preparing porcine hearts for use in a cardiac surgical simulator: A method is described and disclosed for harvesting and preparing porcine hearts that may be used, among other things, as an improved analog of the human heart in cardiac simulator systems for training surgical personnel for performing beating heart surgery.... Agent: Wilmerhale/boston
20090311663 - Organ transplant solutions and method for transplanting organs: A preservation solution for organs waiting to be transplanted is disclosed; the method of using the solution in a transplantation procedure is also disclosed. The preservation solutions comprise a balanced isotonic aqueous solution comprising sodium, potassium, calcium, magnesium and bicarbonate ions in a physiologically acceptable amount, together with an effective... Agent: Frost Brown Todd, LLC
20090311670 - Apparatus and method for measuring concentration of molecules through a barrier: An apparatus and method for detecting the presence and measuring the concentrations of molecules through a barrier and/or at a distance utilizes the principle of chemical/electrostatic attraction (hereinafter “affinity”), i.e., the affinity between charged atoms and molecules that cause their chemical interactions and reactions, to infer, based on the behavior... Agent: Bacon & Thomas, PLLC
20090311668 - In situ detection of early stages and late stages hpv einfection: Embodiments of the invention provide methods, monoclonal antibodies, polyclonal antibodies, assays, and kits for detecting HPV infection and HPV related cancer diagnosis, including infection by various HPV genotypes, early and/or late stage HPV-associated or HPV-specific cancers. The anti-HPV antibodies are used in performing immunological assays on clinical samples. Various immunological... Agent: Shuling Cheng
20090311664 - Method for detection of cancer cells using virus: The invention relates to compositions and methods for cancer cell detection in bodily samples wherein a cancer cell can be detected within a mixed population of cancer cells and non-cancer cells. The invention also relates to compositions and methods that may be used in cancer cell detection, specifically viruses that... Agent: Medlen & Carroll, LLP
20090311665 - Methods, compositions, and kits for collecting and detecting oligonucleotides: Methods, pharmaceutical compositions, and kits are provided which includes accurately sampling a RNA from a tissue of an animal and analyzing RNA in the tissue of the animal as an indicator of physiological state, infectious disease, neoplastic disease, autoimmune disease, inflammatory disease, cardiovascular disease, atherosclerotic disease, or neurological disease in... Agent: Searete LLC Clarence T. Tegreene
20090311666 - Microfluidic device for crystallization and crystallographic analysis of molecules: The present invention relates to a microfluidic device comprising at least one crystallization chamber adapted for comprising a solution in which at least one compound is present according to a concentration gradient, and wherein the geometry of said crystallization chamber allows for convection phenomena to be limited. The invention also... Agent: Arent Fox LLP
20090311667 - Rapid diagnosis method specific to avian influenza virus: The present invention relates to a method for detecting an avian influenza virus by an immunological assay using an anti-influenza virus antibody being unreactive to human influenza type-A virus subtypes H1, H2 and H3 and a human influenza type-B virus and being reactive to plural subtypes of avian influenza viruses,... Agent: Sughrue Mion, PLLC
20090311669 - Signal for packaging of influenza virus vectors: The invention provides a packaging (incorporation) signal for influenza virus vectors, and methods of using the signal to transmit and maintain influenza viral and foreign nucleic acid in virus and cells.... Agent: Schwegman Lundberg & Woessner/warf
20090311675 - Apparatus for monitoring thrombus formation and method of mointoring thrombus formation: An apparatus for monitoring thrombus formation wherein anticoagulated blood is flown through a channel simulating a blood vessel while releasing the anticoagulant treatment or promoting blood coagulation to thereby monitor thrombus formation. This apparatus for monitoring thrombus formation comprises: a thrombus formation chamber in at least a part of which... Agent: J C Patents
20090311682 - Combination of avian cell markers: The present invention relates to a novel combination of avian cell markers which make it possible to characterize the said cells according to their phenotype, whether they are StX cells, stem cells or germ cells. The present invention also relates to a method for characterizing avian cells with the said... Agent: Bozicevic, Field & Francis LLP
20090311704 - Compositions and methods for diagnosis of autophagic vacuolar myopathy: Transmembrane V-ATPase proton pump complexes regulate pH of extracellular space or intracellular compartments of cells. V-ATPase complexes are ubiquitous in cells across species. A human orthologue of yeast vma21, LOC203547 (VMA21), is likely involved in the assembly of the V-ATPase. Hypomorphic mutations of VMA21 are identified from XMEA patients. Methods... Agent: Vedder Price, PC
20090311683 - Compositions for the use in identification of fungi: The present invention provides compositions, kits and methods for rapid identification and quantification of fungi by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.
20090311709 - Compositions, methods, and kits for (mis)ligating oligonucleotides: Methods, reagents, and kits for (mis)ligating oligonucleotide probes or for identifying at least one target nucleotide are disclosed. One can enhance the generation of misligation product using a ligase under reaction conditions and with reagents where that particular ligase is prone to misligation. Alternatively, one can decrease or avoid generating... Agent: Life Technologies Corporation C/o Intellevate
20090311711 - Crh and pomc effects on animal growth: The present invention provides for selection of bovine animals that will display phenotypes associated with increased rates of growth. These phenotypes include hot carcass weight, average daily gain, shipping weight, end of test rib eye area, and adjusted weaning weight which is a measure of post-natal growth, based on the... Agent: Heenan Blaikie LLP
20090311672 - Detection of amplicon contamination during pcr exhibiting two different annealing temperatures: A method to perform PCR reactions with one set of primers comprising sequence elements that are complementary to the target sequence and comprising sequence elements that server as tagging sequences. By conducting amplification reactions at different temperatures, the presence of contaminations arising from amplification products of previous reactions can be... Agent: Komal Shah, Innovarip Consulting Group
20090311671 - Diagnosis of risk of breast cancer: A diagnostic method is disclosed which can he used to predict the risk of cancer, in particular breast cancer. The method comprises: (i) isolating a sample of the patient's genome: and (ii) detecting the presence or expression of the gene comprised within the sequence identified herein as SEQ ID No.... Agent: Marshall, Gerstein & Borun LLP
20090311698 - Diagnostic assay: Certain embodiments of the present invention relate to methods for detecting DNA or RNA (including, but not limited to, mRNA).... Agent: Schwegman, Lundberg & Woessner, P.A.
20090311684 - Enhanced fc receptor-mediated tumor necrosis factor superfamily and chemokine mrna expression in peripheral blood leukocytes in patients with rheumatoid arthritis: A method for predicting patient responsiveness to rheumatoid arthritis treatments involving altering expression of TNFSF-3, TNFSF-4, TNFSF-7, TNFSF-11, or TNFSF-14 is disclosed. A method for monitoring the effectiveness of such therapy is also disclosed. Furthermore, a method of screening compounds for use in the treatment of rheumatoid arthritis is disclosed.... Agent: Knobbe Martens Olson & Bear LLP
20090311689 - Genomic marker for tenderness meat: m
20090311677 - Identification of contaminating bacteria in industrial ethanol fermentations: A method for determining the presence of a contaminating organism in a fermentation process includes initiating the fermentation process using a syngas and obtaining a first aliquot from the fermentation process. The method further includes subjecting said first aliquot to a polymerase chain reaction using at least one oligonucleotide primer... Agent: Cardinal Law Group
20090311692 - Isolation of nucleic acid from mouth epithelial cells: The present invention is directed to a scraping instrument for collection of a biological sample, and a non-invasive method for obtaining nucleic acid from buccal mucosa epithelial cells using the scraping instrument. Such nucleic acid can be used for example for gene expression profiling, including to assess lung disease risk... Agent: Morse, Barnes-brown & Pendleton, P.C. Attn:IPManager
20090311695 - Method: In one aspect, there is described a method for determining the effect of a genetic variation or mutation on the integrity of an RNA transcript comprising the steps of: (a) providing a nucleic acid construct comprising two different reporters separated by an in frame splicing unit, wherein said splicing unit... Agent: Steptoe & Johnson LLP
20090311680 - Method for identifying useful proteins of brewery yeast: The invention relates to a method for identifying a useful protein of brewery yeast. More specifically, the invention relates to (a) cultivating yeast under a predetermined cultivation condition; (b) extracting a protein sample from the cultivation product of the yeast; (c) separating the protein sample by a protein separation means,... Agent: Drinker Biddle & Reath (dc)
20090311676 - Method for preparing primer used for determining the mutation in pds gene related to large vestibular aqueduct syndrome in vitro and the use of the primer: The present invention relates to a method of preparing a primer used for determining the IVS7-2A→G site mutation involved in the large vestibular aqueduct syndrome. The method comprises the steps of: designing a primer pair which may introduce any base substitutive mutation in the region of 1-13 bases between upstream... Agent: Nixon Peabody LLP
20090311693 - Method for the in vitro screening of anti-cancer compounds that inhibits sk3 activity, and said anti-cancer compounds: The present invention relates to methods for the in vitro screening of an anti-metastatic compound that inhibits activity, methods for determining in vitro the presence or absence of a metastatic cancer in a subject by quantifying SK3 activity, methods for the in vitro assessment of the progression of the metastatic... Agent: Young & Thompson
20090311713 - Method of detecting an analyte: The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one application, a method of detecting an analyte is provided and includes providing in a detection window a droplet including a... Agent: Advanced Liquid Logic, Inc. C/o Ward And Smith, P.A.
20090311708 - Method of determining a chemotherapeutic regimen based on ercc1 and ts expression: The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing TS and/or ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and prognosticate the probable resistance of a patient's tumor to treatment... Agent: Kenyon & Kenyon LLP
20090311705 - Method of determining efficiency of ovum collection in bovine: The novel means by which an efficiency of ovum collection can be easily determined in bovine at gene level is disclosed. The present inventors performed the genomic linkage analysis using bovine populations with high and low efficiency of ovum collection and to identify GRIA1 gene, which encodes an ion channel... Agent: Birch Stewart Kolasch & Birch
20090311678 - Method of discriminating at least two cell populations, and application: A subject of the invention is a method for discriminating between and counting at least two populations of biological elements carrying specific characteristics, optionally present in a sample. The invention allows the clear and unambiguous detection of at least three populations of biological elements by the use of only two... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090311712 - Method of screening multiple single nucleotide polymorphisms associated with susceptibility to specific disease or drug response: Provided is a method of screening multiple single nucleotide polymorphisms (SNPs) having significance with a case group, the method comprising: selecting one or more SNPs from nucleic acid sequences of the case group and a control group; generating all combinable genotype patterns of multiple SNPs comprised of two or more... Agent: Cantor Colburn, LLP
20090311699 - Method of surface plasmon resonance (spr) to detect genomic aberrations in patients with chronic lymphocytic leukemia: This invention discloses using SPR technology to detect CLL related genomic aberrations in peripheral blood samples. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of CLL related DNA markers... Agent: Weili Cheng
20090311686 - Method relating to sweetness enhancement: We have discovered a method to enhance sweetness comprising the use of a sweetener at a sub- to near-threshold concentration which is used in combination with a suprathreshold concentration of another sweetener. The sweetener used at the near-threshold concentration is selected based on its likely binding site in the human... Agent: Kenyon & Kenyon LLP
20090311700 - Methods for breast cancer prognosis: The present invention relates to methods, kits and systems for the prognosis of the disease outcome of breast cancer in untreated breast cancer patients. More specific, the present invention relates to the prognosis of breast cancer based on measurements of the expression levels of marker genes in tumor samples of... Agent: Siemens Corporation Intellectual Property Department
20090311703 - Methods for identifying factors for differentiating definitive endoderm: Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.... Agent: Knobbe Martens Olson & Bear LLP
20090311697 - Methods for screening for genetic predisposition to type i diabetes: A method of genetically screening large numbers of individuals to identify those individuals requiring follow-up testing for active Type I diabetes (T1D) is provided. The method includes obtaining a nucleic-acid containing biological sample from each individual and testing for the presence of specific combinations of HLA II alleles in the... Agent: Speckman Law Group PLLC
20090311687 - Microorganisms detection and enumeration method: A method for detecting and enumerating viable microorganisms, preferably selected from the group consisting of Escherichia coli, Legionella spp, Legionella pneumophila and Salmonella spp, in a sample suspected of containing said microorganisms comprising (1) contacting said sample with a cell nutritive resource and a cellular proliferation inhibitor, (2) contacting said... Agent: Young & Thompson
20090311710 - Mutagenesis methods using ribavirin and/or rna replicases: The use of RNA-replicases for introducing mutations into and selecting for improved RNA molecules is described. The use of ribavirin, or a derivative/analogue thereof, in methods for introducing one or more mutations during replication or transcription of a target nucleic acid molecule is also described. These methods can be used... Agent: Frommer Lawrence & Haug
20090311685 - Nmu-ghsr1b/ntsr1 oncogenic signaling pathway as a therapeutic target for lung cancer: The present invention relates to a method of and a kit for assessing the prognosis of lung cancer by detecting the expression level of the neuromedin U (NMU) gene in a patient-derived biological sample. The method and kit are particularly preferred for assessing the prognosis of non-small cell lung cancer... Agent: Townsend And Townsend And Crew, LLP
20090311688 - Novel labeled oligonucleotide: The present invention relates to a labeled oligonucleotide comprising a first nucleotide segment and a second nucleotide segment, complementary to a target sequence, characterized in that it comprises a fluorophore, a quencher and at least one alpha-anomeric nucleoside. The invention also relates to the use of such an oligonucleotide and... Agent: Oliff & Berridge, PLC
20090311673 - Nucleic acid amplification methods: The present invention is directed to devices for performing PCR and monitoring the reaction of a sample comprising a nucleic acid and a fluorescent dye. Illustrative devices comprise a heat exchange component for heating and cooling the sample, a control device for repeatedly operating the heat exchange component to subject... Agent: Ice Miller LLP
20090311691 - Nucleic acid analysis by random mixtures of non-overlapping fragments: The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. Each fragment in such... Agent: Morgan, Lewis & Bockius, LLP (sf)
20090311707 - O-glycans as diagnostic markers for inflammatory bowel disease: The present invention provides diagnostic methods for inflammatory bowel disorders (e.g., Crohn's disease or ulcerative colitis) comprising assessing expression, structure and/or function of O-glycans in a sample from a subject, as well as antibodies to such molecules.... Agent: Fulbright & Jaworski L.L.P.
20090311701 - Organ-specific gene, method for identifying the same and use thereof: e
20090311681 - Pharmacodiagnostic test targeting oncology and neurodegeneration: A first objective of the present invention is to demonstrate a method for the detection and prognosis of cancer and of its metastatic potential. Preferably, the cancer is selected from breast cancer, bladder cancer, ovarian cancer, lung cancer, skin cancer, prostate cancer, colon cancer, liver cancer, a sarcoma and a... Agent: Faure Laurence
20090311674 - Phosphate biosensors and methods of using the same: Phosphate biosensors are disclosed, which comprise a phosphate binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon phosphate binding. Such biosensors are useful for real time monitoring of phosphate metabolism in living cells.... Agent: Morgan Lewis & Bockius LLP
20090311696 - Polymorphisms in the human cyp2b6 gene and their use in diagnostic and therapeutic applications: Described are general means and methods of diagnosing and treating the phenotypic spectrum as well as the overlapping clinical characteristics with several forms of inherited abnormal expression and/or function of the CYP2B6 genes. In particular, polynucleotides of molecular variant CYP2B6 genes which, for example, are associated with insufficient metabolization and/or... Agent: Ropes & Gray LLP
20090311706 - Quantitative analysis of in vivo mutation at the pig-a locus: The invention relates to methods and kits for the quantitative analysis of in vivo mutation frequencies of the Pig-A gene in individuals exposed to a genotoxicant, particularly using peripheral blood samples of vertebrates.... Agent: Nixon Peabody LLP - Patent Group
20090311694 - Splice variants of human il-23 receptor (il-23r) mrna and use of a delta 9 isoform in predicting inflammatory bowel diseases: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A... Agent: Medical Diagnostic Laboratories, LLC
20090311679 - Taqman mgb probe useful for detecting the mitochondrial gene c1494t mutation associated with maternally inherited deafness and the use thereof: The present invention relates to a real time quantitative TaqMan MGB probe useful for detecting the mitochondrial gene C1494T mutation associated with maternally inherited deafness and the use thereof. The present invention design a Taqman mutant probe and a wild type MGB probe, and a pair of primers. A maternally... Agent: Nixon Peabody LLP
20090311702 - Tests to predict responsiveness of cancer patients to chemotherapy treatment options: The present disclosure provides methods and compositions to facilitate prediction of the likelihood of responsiveness of cancer patients to treatment including a taxane and/or a cyclophosphamide.... Agent: Genomic Health, Inc. C/o Kathleen Determann
20090311690 - Vector for screening antibody: It is an object of the present invention to provide a simple and efficient means capable of evaluating the VH/VL interaction without expressing/purifying VH and VL. The present invention provides a recombinant vector comprising: (i) a nucleotide sequence which can express a hetero-assembly composed of two types of fusion proteins... Agent: Birch Stewart Kolasch & Birch
20090311715 - Identifying coronary or soft tissue calcification: This document relates to methods and materials involved in identifying calcification (e.g., coronary calcification or soft tissue calcification) in mammals and assessing thrombotic risk in mammals. For example, methods and materials involved in using microvesicles as a marker to determine whether or not a mammal (e.g., a human) has calcification... Agent: Fish & Richardson P.C.
20090311714 - Methods for the screening of antibacterial substances: The present invention concerns a method for the screening of antibacterial substances comprising a step of determining the ability of a candidate substance to inhibit the activity of a purified enzyme selected from the group consisting of: (i) a D-aspartate ligase comprising a polypeptide having an amino acid sequence possessing... Agent: Fulbright & Jaworski L.L.P.
20090311716 - Methods to treat or prevent hormone-resistant prostate cancer using sirna specific for protocadherin-pc, or other inhibitors of protocadherin-pc expression or activity: The invention is directed to compounds and methods for treating or preventing hormone-resistant prostate cancer using siRNA specific for protocadherin-PC, or other inhibitors of protocadherin-PC expression or activity, including antisense oligonucleotides and antibodies. The invention also provides for the use of protocadherin-PC as an in vivo prostate cancer biomarker, and... Agent: Wilmerhale/columbia University
20090311718 - Degraded agonist antibody: The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist. The modified antibody can... Agent: Foley And Lardner LLP Suite 500
20090311717 - Microfluidic chip design comprising capillaries: The invention provides a microfluidic device wherein capillaries are connected to the microfluidic device by a deformable penetrable substance.... Agent: Banner & Witcoff, Ltd.
20090311720 - Methods of modulating and identifying agents that modulate intracellular calcium: Methods are provided for identifying agents that modulate intracellular calcium. Also provided are methods of modulating calcium within cells and methods of identifying proteins involved in modulating intracellular calcium.... Agent: Wilson, Sonsini, Goodrich & Rosati
20090311721 - Asbestos exposure, pleural mesothelioma, and serum osteopontin levels: The present invention provides diagnostic methods based on the serum levels of osteopontin.... Agent: Davis Wright Tremaine, LLP/seattle
20090311722 - Truncated recombinant major outer membrane protein antigen (r56) of orientia tsutsugamushi strains karp, kato and gilliam and its use in antibody based detection assays and vaccines: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious... Agent: Naval Medical Research Center Attn: (code 00l)
20090311719 - In vitro method for diagnosing neurodegenerative diseases: Disclosed is an in vitro method for the detection, for the determination of the severity and for the assessment of the progress and prediction of neurodegenerative diseases, in which the presence and/or concentration of carbamoyl phosphate synthetase 1 (CPS 1) is determined in a biological fluid of a patient who... Agent: Heslin Rothenberg Farley & Mesiti PC
20090311723 - Fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening: The present invention provides reagents, kits and methods for assaying monoglycerol lipase activity and for identifying compounds that modulate monoglycerol lipase (“MGL”) activity. A simple, sensitive fluorescence assay, which is amenable to high throughput screening, is described. In one embodiment, 7-Hydroxycoumarinyl-arachidonate (7-HCA) is used as a fluorogenic substrate for MGL,... Agent: Wyeth Patent Law Group
20090311726 - Methods and compositions for categorizing patients: The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detection of molecular markers, and methods for identifying candidate molecular markers in... Agent: Ropes & Gray LLP
20090311725 - Polypeptide producing cells: The current invention describes a nucleic acid comprising in a 5′ to 3′ direction a) a first nucleic acid encoding a heterologous polypeptide without an in frame stop codon, b) a second nucleic acid beginning with a 5′ splice donor site and terminated by a 3′ splice acceptor site comprising... Agent: Hoffmann-la Roche Inc. Patent Law Department
20090311727 - Recombinant deamidated gliadin antigen: The present invention provides a method for determining whether a subject is suffering from celiac disease by contacting a sample of bodily fluid from the subject, with an antigen formed from a gliadin fusion protein immobilized on a solid support. The gliadin fusion protein of the antigen includes a recombinant... Agent: Townsend And Townsend And Crew, LLP
20090311724 - Use of additives for the reduction of non-specific binding in assays: A method for reducing non-specific binding in an assay is provided herein. The method includes (a) providing a reaction mixture, which includes or is suspected to include a first component and a second component capable of binding to each other in a specific binding reaction, and (b) adding non-physiological amounts... Agent: Hoffmann & Baron, LLP
20090311729 - Diagnosis of acute enterocolitis by determination of intestinal fatty acid-binding protein in the blood: The I-FABP in collected blood is detected. Preferably, the blood is human blood and I-FABP is human I-FABP, and blood I-FABP is detected by an immunological method. As an immunochemical method, any of an enzyme immunochemical method, a latex agglutination method and an immunochromatography method can be used, and an... Agent: Birch Stewart Kolasch & Birch
20090311728 - Novel platelet activation marker and method for determination thereof: The present invention provides a convenient and highly sensitive method of determining sGPVI present in plasma; this is accomplished by establishing a plurality of mouse hybridomas that produce antibody against GPVI and combining the antibodies produced therefrom. Provided thereby are a novel platelet activation marker, a reagent and method for... Agent: Foley And Lardner LLP Suite 500
20090311730 - Measuring thrombin activity in whole blood: The invention relates to a method for in vitro determining thrombin activity in a sample wherein the sample is a blood sample and thrombin generation is measured by the steps of: —contacting a layer of said sample with a fluorogenic substrate of thrombin, wherein said layer has a thickness within... Agent: Sughrue Mion, PLLC
20090311731 - Modified molecule: We describe a microbial cell, typically a bacterial cell, genetically engineered to produce a modified sugar nucleotide, for example UDP glucuronic acid, and the use of the modified sugar to transfer glucuronic acid to small acceptor molecules.... Agent: Morgan, Lewis & Bockius LLP (sf)
20090311732 - Analytical method for analyzing c-terminus truncation: This invention relates to analytical methods for quantification of truncation at the C-terminus of an Fc-containing protein.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090311733 - Enrichment unit for biological components and an enrichment method: A biological component enrichment unit for the isolation, purification and/or determination of a biological component using particles (3) and/or another solid phase, which enrichment unit comprises at least one sample container (1, 15, 26, 32, 39) for the realisation of the biological sample method. The enrichment unit comprises a lead-through... Agent: Kubovcik & Kubovcik
20090311736 - Integrated apparatus and method to detect inflammatory states present in a sample of whole blood: Integrated apparatus and method for hematological analyses, wherein the apparatus, comprises, arranged substantially in line and integrated substantially in a single machine, a device (14) of the optical type to detect substantially instantaneously the speed of blood sedimentation (ESR) by measuring the optical density, or absorbance, of the blood sample,... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20090311734 - Laser illumination system in fluorescent microscopy: Devices and methods for automated collection and image analysis are disclosed that enable identification or classification of microscopic objects aligned or deposited on surfaces. Such objects, e.g. detectably labeled rare target cells, are magnetically or non-magnetically immobilized and subjected to Time Delay Integration imaging (TDI). Incorporation of TDI technology into... Agent: Philip S. Johnson Johnson & Johnson
20090311738 - Method and system for determining properties of biological cells: A system (100) for determining properties of particles is described, wherein elastic properties of particles can be studied. The system (100) typically comprises a microporous structure (110) having a first side and a second side, the microporous structure comprising a plurality of micropores extending from the first side to the... Agent: Philips Intellectual Property & Standards
20090311737 - Method and device for generating diffusive gradients in a microfluidic chamber: A microfluidic device is described, capable of generating multiple spatial chemical gradients simultaneously inside a microfluidic chamber. The chemical gradients are generated by diffusion, without convection, and can either be maintained constant over long time periods, or modified dynamically. A representative device is described with a circular chamber in which... Agent: Rankin, Hill & Clark LLP
20090311735 - Method for stem cell culture and cells derived therefrom: There is described a method of promoting the attachment, survival and/or proliferation of a stem cell in culture, the method comprising culturing a stem cell on a positively-charged support surface. There are also provided a cell composition prepared according to the method of the invention.... Agent: Scully Scott Murphy & Presser, PC
20090311739 - Device for activating a self-contained biological indicator: The present invention provides a device for activating a self-contained biological indicator. The biological indicator includes a casing, an ampule having a growth-promoting medium disposed therein and microorganisms. The ampule and microorganisms are disposed within the casing. The device is comprised of a first lever arm having a cavity formed... Agent: Kusner & Jaffe Highland Place Suite 310
20090311740 - Colorimetric method and relative device for bacterial load detection: A method for detecting a bacterial load comprising adding a sample for analysis to an analysis reagent in a sterilized reaction container, thermostatting the reaction container at a temperature of between 25 and 45° C., and verifying the change in colouring of the analysis reagent. The analysis reagent is an... Agent: Workman Nydegger 1000 Eagle Gate Tower
20090311741 - Environmental evaluation installation and environmental evaluation method: An environmental evaluation installation including an evaluation chamber 1 isolated from outer space by isolation walls 2, minute substance supply means 3 configured to supply a microorganism into the evaluation chamber 1, a minute substance removing means 4 configured to supply removal particles for removing the microorganism into the evaluation... Agent: Birch Stewart Kolasch & Birch
20090311744 - Expression of o-glycosylated therapeutic proteins in prokaryotic microorganisms: The invention relates to methods of producing an O-glycosylated soluble therapeutic protein in a prokaryotic microorganism by co-expressing the therapeutic protein and a heterologous glycosyltransferase that transfers a sugar moiety to an amino acid acceptor on the therapeutic protein.... Agent: Nada Jain, P.C.
20090311745 - Group of esterases for the enantioselective production of fine and speciality chemicals: The present invention relates to a polynucleotide encoding an enzyme having carboxylesterase [E.C. 220.127.116.11] activity, wherein the coding sequence is selected from the group consisting of (a) a polynucleotide encoding an amino acid sequence as depicted in any one of SEQ ID NOs: 2, 4, 6, 8, 10 and 12;... Agent: Pillsbury Winthrop Shaw Pittman LLP
20090311748 - Heart20049410 polypeptides and methods of making the same: cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of... Agent: Ropes & Gray LLP
20090311746 - Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (mva): The present invention relates to novel insertion sites useful for the integration of exogenous sequences into the Modified Vaccinia Ankara (MVA) virus genome. The present invention further provides plasmid vectors to insert exogenous DNA into the genome of MVA. Furthermore, the present invention provides recombinant MVA comprising an exogenous DNA... Agent: Law Office Of Salvatore Arrigo
20090311749 - Method for methanol independent induction from methanol inducible promoters in pichia: The present invention relates to a method for producing a polypeptide in a methylotrophic yeast host cell, wherein expression of the polypeptide is controlled by a methanol inducible promoter, comprising: i) expression of a positive regulator from a non-native promoter, said positive regulator activating transcription from the methanol inducible promoter,... Agent: Novozymes North America, Inc.
20090311742 - Phage-derived vectors and methods for protein expression: A novel system, including vectors, phage particles, host cells and methods of use, for expressing one or more polypeptides of interest in prokaryotes is described.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20090311743 - Process for the production, in prokaryotes, of active, stable transposases of mariner mobile genetic elements: The present invention relates to a process for the production, by a prokaryotic host cell, of an active, stable transposase of a Mariner mobile genetic element belonging to the mauritiana subfamily. The invention also relates to an active, stable transposase that can be produced using such a process, and to... Agent: Foley And Lardner LLP Suite 500
20090311747 - Vectors and methods for high throughput co-expressions: The present invention includes vectors and methods for high throughput co-expression.... Agent: Mueting, Raasch & Gebhardt, P.A.
20090311750 - Methods of converting fab sequences into single chain antibody sequences: In various embodiments, the present invention provides methods of converting a Fab molecule to a scFv molecule. The methods include amplifying the polynucleotide sequence of the variable light and variable heavy regions of the Fab molecule from the framework 1 to framework 4 sequences; adding one or more restriction endonuclease... Agent: Zymogenetics, Inc. Intellectual Property Department
20090311751 - Wood-rotting basidiomycetes for production of ligninolytic enzymes: The invention relates to the production of ligninolytic enzymes, laccase and manganese peroxidase, from certain white-rot basidiomycetes fungi, using highly efficient fermentation techniques. The aim of this invention is to create a novel economically and time-effective overall procedure comprising use of specific mushroom strains, fermentation process and the isolation-purification techniques,... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090311752 - Conditioning biomass for microbial growth: The present invention relates to methods for improving the yield of microbial processes that use lignocellulose biomass as a nutrient source. The methods comprise conditioning a composition comprising lignocellulose biomass with an enzyme composition that comprises a phenol oxidizing enzyme. The conditioned composition can support a higher rate of growth... Agent: Danisco US Inc. Attention: Legal Department
20090311753 - Method for amplifying genomic dna: A method for amplifying genomic DNA is provided. The method comprises the steps of: (1) incubating a cell-containing agarose solution at a pH of 9 to 12 and a temperature of 45 to 80° C. to produce a genomic DNA-dispersed agarose solution wherein 0.002 to 1 copies/5 microliter of single-stranded... Agent: Gerald T. Shekleton
20090311754 - Polynucleotide amplification: The present invention provides a method for amplifying a pool of polynucleotide molecules in a sample, characterized by the steps of a) obtaining a sample or RNA and reverse transcription of entire RNA molecules thus creating full length cDNA or obtaining a sample of full length cDNA, b) tailing the... Agent: Chalker Flores, LLP
20090311755 - Methods for enhancing the degradation or conversion of cellulosic material: The present invention relates to methods for degrading or converting a cellulosic material and for producing a substance from a cellulosic material.... Agent: Novozymes, Inc.
20090311756 - Microorganisms with a reactivation system for cob(i)alamin-dependent methionine synthase: The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.... Agent: Smith, Gambrell & Russell
20090311757 - Method for producing l-arginine using corynebacterium glutamicum: Disclosed herein are a microorganism producing L-arginine and a method of producing L-arginine using the same. The microorganism is a mutant strain of the genus Corynebacterium, Corynebacterium glutamicum CJR0500. The method for L-arginine production comprises activating the mutant strain C. glutamicum CJR0500 in a fermentation medium at 30° C. for... Agent: Edwards Angell Palmer & Dodge LLP
20090311758 - Process for preparing l-amino acids: A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090311759 - Process for producing (meth) acrylamide: [Means for solving problem] The process for producing (meth)acrylamide of the present invention is a process comprising (a) a step of allowing (meth)acrylonitrile to undergo hydration reaction by the use of a microbial catalyst containing nitrile hydratase in an aqueous medium to obtain a (meth)acrylamide reaction solution (I) and (b)... Agent: Buchanan, Ingersoll & Rooney PC
20090311760 - Host cells and uses thereof in the microbial production of hydroxylated aromatics: The invention relates to the field of the microbial production of substituted aromatics. In particular, it relates to the production of hydroxylated aromatics from renewable carbon stocks, like sugars or glycerol, via the metabolic intermediate L-tyrosine. Provided is a microbial host cell capable of producing at least one hydroxylated aromatic... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP
20090311761 - Process for synthesis of (3s)- and (3r)-3-hydroxy-beta-ionone, and their transformation to zeaxanthin and beta-cryptoxanthin: The present invention relates to a process for the synthesis of (3R)-3-hydroxy-β-ionone and its (3S)-enantiomer in high optical purity from commercially available (rac)-α-ionone. The key intermediate for the synthesis of these hydroxyionones is 3-keto-α-ionone ketal that was prepared from (rac)-α-ionone after protection of this ketone as a 1,3-dioxolane. Reduction of... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090311762 - Oxidoreductases for the stereoselective reduction of keto compounds: The invention relates to a process for the enantioselective enzymatic reduction of a keto compound to the corresponding chiral hydroxy compound, wherein the keto compound is reduced with an oxidoreductase in the presence of a cofactor, and is characterized in that an oxidoreductase is used which has an amino acid... Agent: Workman Nydegger 1000 Eagle Gate Tower
20090311763 - Production of peracids using an enzyme having perhydrolysis activity: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.
20090311764 - Process of obtaining ethanol without glucoamylase using pseudomonas saccharophila g4-amylase and variants thereof: Pseudomonas saccharophila G4-forming amylase (PS4), and variants thereof, advantageously can be used in an enzyme-catalyzed high temperature liquefaction step to produce ethanol from starch, e.g., cornstarch. PS4 produces significant amounts of maltotrioses, which can be utilized by S. cerevisiae in a subsequent fermentation step to produce ethanol. This property of... Agent: Danisco US Inc. Attention: Legal Department
20090311765 - Alginate poly-l-lysine encapsulation as a technology for controlled differentiation of embryonic stem cells: Alginate polyelectrolyte encapsulation is used for the controlled differentiation of embryonic stem cells. An isolated cell population is provided. The cell population includes a single cell suspension of ES cells encapsulated within an alginate polyelectrolyte microenvironment. The encapsulated ES cells are capable of differentiating within said microenvironment into hepatocyte lineage... Agent: Daniel A Scola James F Harrington Hoffmann & Baron
20090311766 - Apparatus and method for hydrolyzing biological material: Apparatus and method for hydrolyzing biological material for safe disposal thereof without the necessity of incineration or use of disinfectants are described. An alkaline solution having a concentration and an amount effective for hydrolyzing the biological material is brought into contact therewith by means of rotating paddles which both pound... Agent: Cochran Freund & Young LLC
20090311767 - Method for molecular delivery into cells using naonotube spearing: The present invention discloses a method of delivering a macromolecule to a cell, comprising engaging the macromolecule to a nanotube wherein the nanotube comprises a magnetic particle, placing the nanotubes into a sample wherein the sample comprises a plurality of cells and applying a force to the sample wherein the... Agent: Greenberg Traurig, LLP
20090311769 - Thermostable luciferases and methods of production: Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases, are disclosed. Methods of producing the luciferases include recursive mutagenesis. The luciferases are used in conventional methods, some employing kits.... Agent: Schwegman, Lundberg & Woessner, P.A.
20090311768 - Thermostable superoxide dismutase: The present invention provides a thermostable superoxide dismutase from a thermophile. The thermostable superoxide dismutase that is able to catalyze the conversion of superoxide ions or radicals under the moderate to high temperature environments.... Agent: J C Patents
20090311770 - Method of collecting microorganisms using fine particles, method of collecting nucleic acids using fine particles, and kits for use in the these methods: The present invention provides a method of collecting microorganisms and a method of collecting nucleic acids, which both can be carried out easily and can achieve a high collection rate. A method of collecting microorganisms according to the present invention includes a microorganism adsorption step of bringing a sample into... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20090311771 - Arabinose-and xylose-fermenting saccharomyces cerevisiae strains: The present invention relates to a S. cerevisiae strain expressing both arabinose and xylose utilization pathways, and in particular to a S. cerevisiae strain fermenting both arabinose and xylose to ethanol, and more particularly a S. cerevisiae strain with overexpression or upregulation of xylose- or aldose reductase (XR, AR) with... Agent: Gauthier & Connors, LLP
20090311772 - Micro refinery for ethanol production: A micro refinery system includes a fermentation tank, a distillation tube and a membrane ethanol separation mechanism. A batch that includes sugar, yeast and water is mixed in the fermentation tank. Sensors detect the physical characteristics of the batch and the operating status of the system. The sensors are coupled... Agent: Dergosits & Noah LLP
20090311773 - Novel apparatus and method for coating substrates for analyte detection by means of an affinity assay method: The invention relates to several embodiments of equipment for coating substrates for detecting one or more analytes by way of an affinity assay method, comprising: a receptacle receiving a liquid to be atomized (“liquid receptacle”) with substances (compounds) to be deposited onto at least one surface of said substrates and... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090311774 - Bioassay system including optical detection apparatuses, and method for detecting biomolecules: A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090311775 - Disposable bioreactor for culturing cells in a nutrient medium: Disposable bioreactor for culturing cells in a nutrient medium, consisting of a reagent container which is sealable with a lid and which is capable of being subjected to a shaking process in a shaking device, where the reagent container is equipped with at least one web adjacent to the internal... Agent: Casella & Hespos
20090311776 - Stirred tank bioreactor: The present invention is a disposable bioreactor formed of molded plastic. The bioreactor is presterilized and has a top and body sealed to each other. One or more ports are formed in the top and side of the housing. Preferably at least one port is below the liquid/air level for... Agent: Millipore Corporation
20090311777 - Bioreactor: The present invention relates to a bioreactor comprising a first fluid distribution chamber and a first fluid collection chamber, the reactor adapted to receive at least one conduit in fluid communication between the first fluid distribution chamber and the first fluid collection chamber; wherein the reactor includes a second fluid... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090311778 - Supply system for cell culture module: A device for supplying cell culture modules with nutrients has an arrangement of channels, pumps and valves in or on a plate. The valves may be pinch valves operated by deforming an elastic cover over a solid body and the pump may be a pinch valve pump. The channels may... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.
20090311779 - Anti-p-selectin antibodies: This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or... Agent: Hoffmann-la Roche Inc. Patent Law Department
20090311780 - Minimally immunogenic variants of sdr-grafted humanized antibody cc49 and their use: Humanized anti-TAG-72 CC49 monoclonal antibodies are disclosed herein. The antibodies include a light chain Complementarity Determining Region (L-CDR)1, a L-CDR2, and a L-CDR3; and a heavy chain Complementarity Determining Region (H-CDR)1, a H-CDR2, and a H-CDR3 from humanized antibody HuCC49V10. The L-CDR1, L-CDR2, L-CDR3 are within a HuCC49V10 light chain... Agent: Klarquist Sparkman, LLP
20090311782 - Method for promoting differentiation of stem cell into insulin producing cell: A method for promoting a differentiation of stem cells into insulin producing cells is provided. The method includes steps of suspending the stem cells in a first culture medium, aggregating the stem cells to form a cell pellet, and culturing the cell pellet in a second culture medium to promote... Agent: Volpe And Koenig, P.C.
20090311781 - Methods of expanding embryonic stem ceels in a suspension culture: A method of expanding and maintaining human embryonic stem cells (ESCs) in an undifferentiated state by culturing the ESCs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving ESC lines in the suspension culture and methods of generating lineage-specific... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090311784 - Cytotoxic ribonuclease variants: This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase... Agent: Quarles & Brady LLP
20090311783 - Insulin-like growth factor-i receptor antagonists: The present invention relates to IGF-I variants that bind to the Insulin-like Growth Factor Receptor I (IGF-IR) but do not initiate signal transduction and the subsequent metabolic, growth and anti-apoptotic activities associated with this molecule and the progression of cancer. These novel variants act to block the binding of the... Agent: Elmore Patent Law Group, PC
20090311785 - Method for organizing and controlling cell growth and tissue regeneration: A method for organizing and controlling cell growth on a cell-free structure comprises steps of decellularizing a biological material to produce an acellular matrix; adding cells sought to be propagated to the acellular matrix; coating the acellular matrix with a fiber comprising biological and nonbiological material; and storing the covered... Agent: Louis Ventre, Jr
20090311787 - Engineered cleavage half-domains: Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.... Agent: Robins & Pasternak
20090311786 - Levels and/or sustainability of dna-based gene expression: The invention encompasses methods for improving the level and/or sustainability of expression for a target nucleic acid in a eukaryotic cell comprising: (a) modifying the target nucleic acid to introduce or to comprise signals that limit or constrain the positions of nucleosome cores, and (b) introducing the modified target nucleic... Agent: Morgan Lewis & Bockius LLP
20090311789 - Method for preparing differentiated avian cells and genes involved in maintaining pluripotency: The present invention relates to a method for preparing differentiated avian cells from stem cells in culture. Genes involved in maintaining the pluripotency of avian stem cells were identified and cloned. By inhibiting the expression of these genes in stem cells, the latter lose their pluripotency characteristics and enter into... Agent: Bozicevic, Field & Francis LLP
20090311790 - Method of directing the evolution of an organism: The present disclosure relates to a method of directing the evolution of an organism by modifying the mutation rate of an organism. The increase in genetic diversity may be used to facilitate the selection of a desired hereditary trait in an organism.... Agent: Stoel Rives LLP - Slc
20090311788 - Multiple-compartment eukaryotic expression systems: Method and constructs for expressing heterologous sequences of interest in eukaryotic cells using multiple-compartment expression systems. These systems, which may be comprised of a single construct or multiple constructs, utilize at least two different promoters which are each active within a different subcellular compartment of the same eukaryotic cell. The... Agent: David S. Resnick
20090311791 - Alpha-hemolysin deletion mutation of ses-producing staphylococcus aureus and construct thereof: The present invention relates to an α-hemolysin-deletion mutant of SEs-producing Staphylococcus aureus and a construction method thereof. Said mutant is a genetically engineered strain obtained by deleting an α-hemolysin (α-HL) gene of a wild type Staphylococcus aureus strain by a homologous recombination method. The genetically engineered strain has the same... Agent: Leong C Lei12/10/2009 > patent applications in patent subcategories.
20090305223 - Method and apparatus for evaluatiing interactions in isolated tissue: An apparatus for evaluating the effects of stimuli on tissue includes an environment for holding at least a sample of the tissue from a living person. The apparatus also has a first source connected to the environment for delivering nutrients to the tissue to maintain the tissue in a viable... Agent: Barnes & Thornburg LLP
20090305222 - Organ preservation solution: The invention relates to the field of organ and biological tissue preservation and in particular to solutions for use in preserving organs and/or tissues prior to transplanting into a subject.... Agent: Myers Bigel Sibley & Sajovec
20090305224 - Methods for the cryopreservation of mammalian cells: The present invention features novel methods for the cryopreservation of mammalian cell that combine the advantages of the slow-freezing and vitrification approaches while avoiding their shortcomings. Generally, the methods include the use of a capillary tube made of a thermally conductive wall material and a thin wall such that the... Agent: Clark & Elbing LLP
20090305225 - Inhibition of creatine uptake to promote weight loss: The present invention provides a method of promoting weight loss, or treating or preventing a body disorder related to excess weight, in a subject. The method comprises administering to the subject an effective amount of a creatine uptake inhibitor. Administration of the creatine uptake inhibitor is intracranial or directed to... Agent: David S. Resnick
20090305226 - Biomolecular recognition of crystal defects: Discrete and diffuse defects in a surface are detected. Discrete defects that may compromise the performance may be repaired.... Agent: Choate, Hall & Stewart LLP
20090305227 - Hiv-1 latency model for high throughput screening: Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I derived vector pro virus, which upon activation expresses a marker for late viral gene expression due to the insertion... Agent: Hoffmann & Baron, LLP
20090305229 - Multiplex detection of respiratory pathogens: Described are kits and methods useful for detection of respiratory pathogens (influenza A (including subtyping capability for H1, H3, H5 and H7 subtypes) influenza B, parainfluenza (type 2), respiratory syncytial virus, and adenovirus) in a sample. Genomic sequence information from the respiratory pathogens was analyzed to identify signature sequences, e.g.,... Agent: Llnl/fenwick John H. Lee, Assistant Laboratory Counsel
20090305232 - Peptides for detection of antibody to porcine reproductive respiratory syndrome virus: The invention provides compositions and methods for the detection and quantification of PRRSV antibodies and antibody fragments using polypeptides.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090305228 - Potentiation of apoptosis by monoclonal antibodies: The present invention relates to the use of an antibodies composition, the fucose content of which is less than 65%, for indicating apoptosis in vitro.... Agent: Leyendecker & Lemire, LLC
20090305230 - Real time detection of molecules, cells and particles using photonic bandgap structures: Provided herein is a photonic bandgap (PBG) detector effective to detect inorganic molecules, organic biomolecules or biopolymers, cells, subcellular organelles, and particles. The PBG detector utilizes photonic crystals having a binding agent attached to channel surfaces comprising the crystals to selectively bind a molecule, cell or particle of interest so... Agent: Adler & Associates
20090305231 - Sensitive immunoassays using coated nanoparticles: Coated nanoparticles comprising a core surrounded by a shell that increases the reflectance of the nanoparticle, wherein the coated nanoparticle does not include a Raman-active molecule, are provided. Test devices and immunoassay methods utilizing the coated nanoparticles are provided.... Agent: David W. Highet, Vp And ChiefIPCounsel Becton, Dickinson And Company
20090305291 - method and a microdevice for the identification and/or quantification of an analyte in a biological sample: A method and device, based on a film of a luminescent substance, such as colloidal semiconductor nanocrystals dispersed in a polymer matrix, for conducting quantitative and real-time analyses of PCR processes or of biomolecular interactions in genomics and/or proteomics. The optical detection system is based on FRET processes between the... Agent: Sughrue Mion, PLLC
20090305255 - substrate protein for m-phase kinase and use thereof: An isolated protein of (a) a protein having an amino acid sequence of SEQ ID No. 2; (b) a protein having an amino acid sequence partially different from the amino acid sequence of SEQ ID No. 2 that is a substrate of M-period kinase and has nucleic acid-methylating activity suppressed... Agent: Birch Stewart Kolasch & Birch
20090305270 - Antigenic surface structure of sperm cells associated with the y chromosome: The present invention relates to an antigenic surface structure of sperm cells associated with the Y chromosome, to the molecules, in particular antibodies, directed against this antigenic structure and to a method for characterizing cells carrying only the Y chromosome through the interaction between this antigenic structure and the molecules... Agent: Harness, Dickey & Pierce, P.L.C
20090305285 - Asymmetric cyanine compounds, their preparation methods and their uses: Asymmetric cyanine compounds represented by general formula I are provided, wherein X, n, R1, R2, R3, R4 and Y− are as defined in the specification. They have a maximum absorption peak at about 640 nm which may not change with ambient temperature. When the compounds bind a nucleic acid to... Agent: Mindray C/o Stoel Rives LLP
20090305257 - Biomarkers downregulated in prostate cancer: Biomarkers are identified by analyzing gene expression data using support vector machines (SVM), recursive feature elimination (RFE) and/or linear ridge regression classifiers to rank genes according to their ability to separate prostate cancer from normal tissue. Proteins expressed by identified genes are detected in patient samples to screen, predict and... Agent: Procopio, Cory, Hargreaves & Savitch LLP
20090305251 - Brca1/brca2 screening panel: A method for analyzing a biological sample is performed by analyzing a biological sample for the presence of one or more mutations or polymorphisms in the BCRA1 and/or BCRA2 genes.... Agent: Gregory A. Nelson Novak Druce & Quigg LLP
20090305283 - Cleavage of nucleic acids: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a... Agent: Casimir Jones, S.c.
20090305293 - Compositions and methods to detect candida albicans nucleic acid: Compositions are disclosed as nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes specific for Candida albicans 26S rRNA sequences or DNA encoding 26S rRNA. Methods are disclosed for detecting the presence of C. albicans in samples by using... Agent: Gen Probe Incorporated
20090305264 - Cooperative probes and methods of using them: The present invention provides inter alia, cooperative probe assays for analyzing and identifying biological substances.... Agent: Woodcock Washburn LLP
20090305250 - Determination of the biological function of a target gene in a cell: Disclosed herein is a method to determine the biological function(s) of a target gene in a cell, the steps of which involve separately culturing a first population and a second population of the cell under same culturing conditions, the first population of the cell differing from the second population of... Agent: Occhiuti Rohlicek & Tsao, LLP
20090305241 - Dna demethylases and uses thereof: Polypeptides with DNA demethylase activity as well as methods of their use are provided.... Agent: Townsend And Townsend And Crew, LLP
20090305256 - Dna methylation biomarkers for lung cancer: The present invention relates to the identification of novel DNA biomarkers and the use of the aberrant methylation patterns of the biomarkers to diagnose a disease or a condition (e.g., a cancer) associated therewith. In particular, the present invention relates to the use of the novel DNA biomarkers to diagnose... Agent: Perkins Coie LLP
20090305292 - Dna polymerase: The present invention relates to DNA polymerases. In particular the invention relates to a method for the generation of DNA polymerases exhibiting a relaxed substrate specificity. Uses of mutant polymerases produced using the methods of the invention are also described.... Agent: Edwards Angell Palmer & Dodge LLP
20090305275 - Dnas and proteins or peptides specific to bacteria of the species neisseria meningitidis, process for obtaining them and their biological uses: The DNA of the invention are characterised in that they concern the whole or pan of genes, with their reading frame, to be found in Neisseria meningitidis, but not in Neisseria gonorrhoeae, or in Neisseria lactamica except the genes involved in the biosynthesis of the polysaccharide capsule, frp A, frp... Agent: Nixon & Vanderhye, PC
20090305259 - Early diagnosis of congenital abnormalities in the offspring of diabetic mothers: The present invention relates to the identification of a series of biomarkers, the detection of which is prognostic for women at risk of becoming hyperglycemic during pregnancy and/or fetuses at risk of developing congenital anomalies as a result of maternal hyperglycemia.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20090305277 - Gene expression markers for prediction of patient response to chemotherapy: The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment of prognosis and/or prediction of patient response to chemotherapy, using expression analysis.... Agent: Genomic Health, Inc. C/o Kathleen Determann
20090305295 - Identification of a gene expression profile that differentiates ischemic and nonischemic cardiomyopathy: A method of preparing a gene expression prediction profile for distinguishing ischemic and nonischemic cardiomyopathy comprises the steps of obtaining clinical specimens from patients suffering from ischemic or nonischemic cardiomyopathy, isolating nucleic acid sequences from at least a plurality of said specimens, obtaining a gene expression level corresponding to each... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.
20090305271 - In vitro assay based on camp levels modulated by gi-coupled receptors: The present invention relates to a reliable and effective in vitro assay based on cAMP levels modulated by Gi-coupled receptors expressed in a selected cell for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor.... Agent: Nixon & Vanderhye, PC
20090305265 - Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease: The present invention includes methods for the use of interleukin-33 (IL-33) in the diagnosis of cardiovascular conditions including acute coronary syndrome (ACS), myocardial infarction, and/or heart failure, angina, cardiac hypertrophy, arteriosclerosis, myocarditis, pancarditis, endocarditis, stroke and/or pulmonary embolism and the determination of the severity of such conditions (prognosis).... Agent: Fish & Richardson PC
20090305290 - Lateral flow nucleic acid detector: Point-of-care binding assays include at least one target nucleic acid binding in a multiplex structure with at least one sequence in a partner nucleic acid associated with a label, due to complementary base pairings between at least one sequence in the target nucleic acid and at least one sequence in... Agent: Brown & Michaels, PC 400 M & T Bank Building
20090305280 - Luciferase biosensors for camp: A modified luciferase protein which is a sensor for molecules including cAMP is provided. The modified luciferase protein includes one or more heterologous amino acid sequences, at least one of which directly or indirectly interacts with cAMP.... Agent: Schwegman, Lundberg & Woessner, P.A.
20090305254 - Method and apparatus for assaying test substance in sample: Disclosed are a method for assaying a target substance in a sample and an apparatus for the method. The method can specifically assay the target substance in the sample without using any antibody against the target substance. The assaying method includes simultaneously or successively bringing a labeled aptamer, the target... Agent: Edell, Shapiro & Finnan, LLC
20090305287 - Method and system for multiplex genetic analysis: A method for identifying nucleotides in a nucleic acid sequence is disclosed. A plurality of polymerization complexes are provided within a plurality of confined reaction environments. Each complex comprises a polymerase enzyme and a template nucleic acid. The plurality of complexes are contacted with a plurality of types of nucleotide... Agent: Life Technologies Corporation C/o Intellevate
20090305274 - Method for determining azole resistance in candida glabrata: There is disclosed a method for determining azole resistance in Candida glabrata. A biological sample containing Candida glabrata is obtained and a normalized mRNA level of CDR1 gene is determined using qRT-PCR. Using a microbroth dilution assay conducted at azole concentrations of about 2-8 μg/mL, a susceptible isolate of Candida... Agent: Medical Diagnostic Laboratories, LLC
20090305276 - Method for predicting skin sensitizing activity of compounds: The present invention provides methods for predicting the in vivo skin sensitizing activity of chemical compounds using a combination of mammalian cell models with multiple endpoint analysis, time and concentration response curves. The methods allow the determination of a predicted in vivo sensitization value of a compound—for example, a EC3... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090305286 - Method for the identification of suitable fragmentation sites in a reporter protein: The invention concerns a combinatorial method for the generation of new split-protein sensors, and its application towards the (β/α)8-barrel enzyme N-(5′-phosphoribosyl)-anthranilate isomerase Trp1p from Saccharomyces cerevisiae is demonstrated. The generated split-Trp protein sensors allow for the detection of protein-protein interactions in the cytosol as well as the membrane by enabling... Agent: Shoemaker And Mattare, Ltd
20090305272 - Method of characterizing endogenous polynucleotide-polypeptide interactions: A method for characterizing an endogenous polypeptide includes introducing epitope tag-encoding polynucleotide into an endogenous locus of a somatic cell by homogenous recombination mediated knock-in so that an epitope tagged endogenous polypeptide is expressed by the cell, and characterizing the epitope tagged endogenous polypeptide using an immunoassay.... Agent: Tarolli, Sundheim, Covell & Tummino, LLP
20090305249 - Method of detecting cyp2a6 gene variants: The present invention relates to methods for amplifying various regions of the CYP2A6 gene. Methods are provided for amplifying one or more fragments of the CYP2A6 gene in a single tube. The methods can identify mutations, deletion, duplication, and/or rearrangement in a sample containing the CYP2A6 gene.... Agent: Foley & Lardner LLP
20090305268 - Method of determining an amount of fatty acid contents in bovine intramuscular fat on the basis of genotype of fatty acid synthase gene and method of determining goodness of eating quality of beef on the basis of the results thereof: e
20090305279 - Method of diagnosis: Provided are methods, kits and arrays for use in determining whether a scar of interest is keloid or non-keloid in nature. These determine keloid or non-keloid nature based on comparison of gene expression in the scar of interest with expression in a control sample. If expression of at least one... Agent: Baker & Daniels LLP
20090305245 - Method of examining zinc-deficient taste disturbance: The present invention provides: a method for testing zinc deficiency dysgeusia, which is characterized in that it comprises correlating the expression levels of a gene encoding a gustatory receptor belonging to the THTR family and a gene encoding a gustatory receptor belonging to the T2R family obtained from a sample... Agent: Birch Stewart Kolasch & Birch
20090305294 - Method of isolating nucleic acids from stool samples: The present invention relates to a method of isolating a nucleic acid molecule form a biological sample. More particularly, the present invention relates to a method of isolating ribonucleic acid molecule from a biological sample. The method of the present invention is useful in a range of applications including, but... Agent: Scully Scott Murphy & Presser, PC
20090305239 - Methods and compositions for determing a level of biologically active serum paraoxonase: A method of determining a level of biologically active PON enzyme is provided. The method comprising determining lactonase activity of the PON enzyme, the lactonase activity being indicative of the level of biologically active PON enzyme. Also provided are novel compounds which may be used for measuring a lactonase activity... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090305253 - Methods and compositions related to the modulation of riboswitches: Disclosed herein are methods and compositions related to the detection of conformational changes and interactions with trigger molecules in riboswitches.... Agent: Ballard Spahr LLP
20090305233 - Methods and reagents for polynucleotide assembly: The present invention provides methods, compositions, and kits for polynucleotide assembly.... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC
20090305252 - Methods and species-specific primers for detection and quantification of streptococcus mutans and streptococcus sanguinis in mixed bacterial samples: Dental caries is a polymicrobial infectious disease. Of the hundreds of bacteria present in the biofilms coating teeth, the Streptococcus mutans (S. mutans) remain strongly linked to caries and dental disease. Streptococcus sanguinis (S. sanguinis) may serve a protective or antagonistic role against the cariogenic bacterium S. mutans. In the... Agent: Klauber & Jackson
20090305288 - Methods for amplifying nucleic acids and for analyzing nucleic acids therewith: An object of the present invention is to control the increase in amplification errors generated during the nucleic acid amplification and thus to obtain an amplification product having a good reproducibility. The present invention is characterized in that a target nucleic acid to be amplified is amplified through a two-stage... Agent: Scully Scott Murphy & Presser, PC
20090305284 - Methods for identifying risk of breast cancer and treatments thereof: Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments... Agent: Grant Anderson LLP C/o Portfolioip
20090305248 - Methods for increasing accuracy of nucleic acid sequencing: The invention provides methods for improving the fidelity of a sequencing-by-synthesis reaction by resequencing at least a portion of a nucleic acid template.... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090305258 - Methods for the diagnosis of proliferative and/or conformational diseases: The present invention discloses methods to diagnose and/or to make prognostic predictions and/or to monitor the efficacy of a therapy of a proliferative or conformational disease, or to establish the state of ageing in a subject. Kit for performing such methods are also disclosed.... Agent: Kenneth K. Sharples The Law Office Of Kenneth K. Sharples
20090305236 - Methods of enriching fetal cells: The present invention relates to methods of enriching fetal cells from a pregnant female. The present invention relates to removing, from a sample, cells that comprise at least one MHC molecule. The present invention also relates to methods that rely on using telomerase, mRNA encoding components thereof, as well as... Agent: Wilmerhale/boston
20090305238 - Microarray microcard: A fluid processing device is provided that comprises a substrate including a surface and a fluid processing pathway at least partially formed in or on the surface. The fluid processing pathway can comprise a channel, a reaction region in fluid communication with the channel, a microarray in fluid communication with... Agent: Kilyk & Bowersox, P.l.l.c.
20090305267 - Microbial markers of inflammatory bowel disease: The present invention relates to bacterial serine protease autotransporter (SPATE) and Antigen 43 (Ag43) and their various uses relating to inflammatory bowel disease (IBD), specifically in the diagnosis of IBD and the screening of potential agent for treating IBD. The invention also relates to methods for cultivating and identifying enteric... Agent: Smart & Biggar P.o. Box 2999, Station D
20090305273 - Nanonozzle device arrays: their preparation and use for macromolecular analysis: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macro-molecules using such devices.... Agent: Woodcock Washburn LLP
20090305247 - Nanoparticle and methods therefor: There is provided an electroactive nanoparticle, which may be used as a label in electrochemical detection assays. The nanoparticle comprises a transition metal oxide and a capping agent, the capping agent comprising a ligand group and a functional group. The capping agent is coordinated to a transition metal centre in... Agent: Klarquist Sparkman, LLP
20090305282 - Novel human virus causing respiratory tract infection and uses thereof: The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen. China. The virus belongs to the order Nidovirales of the family Coronavirdae, being a single-stranded RNA virus... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090305281 - Novel inhibitors of retroviral reverse transcriptace: Disclosed are nucleic acid molecules, and methods of their use, which have a specific structure including a double helical domain and a G-quadruplex domain physically connected by a linker domain which may be nucleosidic or non-nucleosidic. These aptamers demonstrate potent inhibition of phylogenetically diverse primate lentiviral reverse transcriptases, which effect... Agent: Polsinelli Shughart PC
20090305235 - Novel targets for the identification of antibiotics that are not susceptible to antibiotic resistance: To identify conserved and variable regions of the 16 S rRNA, an instant evolution experiment was performed on the entire 16 S rRNA. Analysis of these mutants identified regions that are required for function. These conserved sequences may be used as targets for pharmaceuticals that are taxonomically specific and which... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20090305269 - Pcr screening method: A tooling system (1) having a number of elements (2) arranged in an array, which elements define a contoured surface, or a section of a contoured surface. The tooling system also including means (7) for mounting an element to a support rail (5) which extends across the array, which means... Agent: Syngenta Crop Protection , Inc. Patent And Trademark Department
20090305260 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 59 to 61 or a combination of at least two of... Agent: Fitzpatrick Cella Harper & Scinto
20090305261 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 65 to 67 or a combination of at least two of... Agent: Fitzpatrick Cella Harper & Scinto
20090305262 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 56 to 58 or a combination of at least two of... Agent: Fitzpatrick Cella Harper & Scinto
20090305263 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 43 to 45 or a combination of at least two of... Agent: Fitzpatrick Cella Harper & Scinto
20090305237 - Quantification of nucleic acids and proteins using oligonucleotide mass tags: The invention provides a method for detecting and quantifying the amount of target molecules, such as nucleic acids or proteins in a sample. The target molecules are first recognized and bounded by target-specific probes, generally nucleic acids or proteins that bind specifically to the targets, each of which is labeled... Agent: Ronald I. Eisenstein
20090305246 - Schizophrenia associated genes and markers: The invention discloses schizophrenia-associated polymorphism located on chromosome 6q23 within the human Abelson Helper Integration Site 1 gene (AHI1), or a genomic region linked to the AHI1 gene that includes the C6orf217 gene. The invention further discloses systems and methods for diagnosing schizophrenia or predisposition to schizophrenia.... Agent: Winston & Strawn LLP Patent Department
20090305289 - Screening method to identify protective substances for the treatment of neurodegenerative and/or ischaemic diseases: The present invention relates to a screening method for the identification of protective substances which influence haemoglobin formation in neuronal, myocardial and/or skeletomuscular cells, as well as to recombinant constructs, host cells and transgenic animals for the implementation of this method. In addition, the present invention relates to a diagnostic... Agent: Townsend And Townsend And Crew, LLP
20090305244 - Selection, propagation and use of mosaic aneuploid stem cells: The distribution of cell karyotypes within a population of cells can determine the phenotype and ability of stem cells to differentiate into desired cell types, to function normally, as well as represent risk for adverse events like cancer. Therefore, determination of the aneuploid mosaic status of a cell population is... Agent: The Scripps Research Institute
20090305278 - Sequence determination in confined regions: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Life Technologies Corporation C/o Intellevate
20090305242 - Skin aging marker and technique for use thereof: It is an object of the present invention to find substances that can be used as skin aging markers, and the present invention provides a method for determining the degree of skin aging, including measurement of expression of secretory proteins and/or intracellular proteins and/or their genes in skin cells and/or... Agent: Knobbe Martens Olson & Bear LLP
20090305234 - Specific dnas for epigenetic characterisation of cells and tissues: The present invention provides methods, nucleic acids and molecular markers for the characterization of cells, tissues and heterogeneous mixtures of cells. Specifically, it describes particular genes and genomic regions in which DNA methylation patterns are a consistent and characteristic property of different cell types, states and stages of differentiation. The... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090305266 - Test for ovarian cancer by detecting abnormality in fancd2 pathway: Methods are provided for determining diagnosing ovarian and breast cancer in a subject, including diagnosing the predisposition of a subject's risk of developing breast or ovarian cancer. The methods include selecting a subject, for example a subject with one or more risk factors for developing ovarian cancer or breast cancer,... Agent: Klarquist Sparkman, LLP
20090305298 - Binder for c-reactive protein: A polypeptide dimer is provided wherein both protomers have a sequence according to SEQ ID NO: 1 and at least one phosphocholine derivative is attached to the polypeptide. The polypeptide shows a specific binding for C-reactive protein (CRP). The utilization of the polypeptide in assays for determining the concentration of... Agent: Buchanan, Ingersoll & Rooney PC
20090305301 - Detection of venous thromboembolic diseases by measurement of d-dimers and soluble fibrin levels: A method and a test for detecting coagulation activation, in particular when it is responsible for thromboembolic venous diseases; employs assaying D-dimers and assaying the soluble fibrin produced during a fibrinolysis process activated in a blood sample. The method of the invention pertains to comparing the level of D-dimers corresponding... Agent: Young & Thompson
20090305299 - Method for determination of prognosis of prostate cancer, and diagnostic agent for use in the method: A method for determining probability that prostate cancer will metastasize, as well as a diagnostic reagent used therefor is disclosed. It was discovered that the percentage that NF-κB-p65/RelA has the 254th amino acid threonine which is phosphorylated is significantly higher in the prostate cancer cells in the cases where the... Agent: Birch Stewart Kolasch & Birch
20090305300 - Methods and kits to diagnose growth hormone deficiency: A method of assessing growth hormone deficiency in a human or animal subject, the method comprising administering orally to the subject EP 1572 (Formula I) or EP 1573 (Formula II), obtaining a post-administration sample from the subject, determining the level of growth hormone in the sample and assessing whether the... Agent: Nixon Peabody LLP - Patent Group
20090305302 - Mycobacterial culture screening test for mycobacterium avium complex bacteria: A method of antigen-capture assays that uses the detection of antigens secreted into liquid culture is provided. Also provided are antibodies to Mycobacterium avium complex-specific antigens, and diagnostic kits and systems for the detection of the presence of mycobacteria in liquid samples.... Agent: Warf/bhgl
20090305296 - Test kit for detecting periodontal disease: A test kit is disclosed for diagnosing periodontal disease in a patient by analysing a sample from the oral cavity of the patient. The test kit includes at least a first detection assay for detection of a first substance originating from bacteria and at least a second detection assay for... Agent: Harness, Dickey & Pierce, P.L.C
20090305297 - Tyrosine phosphorylation sites: The invention discloses 397 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel
20090305303 - immunochromatography device for the diagnosis of diseases in a sample: An immunochromatography device for determining the presence of a binding analyte in a biological sample of a subject, includes the steps of a sample application site for receiving the biological sample; at least one conjugate pad allowing the binding analyte present in the biological sample to bind to a labeled... Agent: Bachman & Lapointe, P.C.
20090305304 - High resolution label free analysis of cellular properties: The invention provides methods of detecting a change in cell growth patterns.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090305305 - Method and probes for the detection of a tumor-specific fusion protein: The invention relates to the detection of fusion proteins. Described are a set of at least a first and a second molecular probe, each probe provided with a dye wherein the dyes together allow energy transfer, at least one probe provided with a reactive group allowing juxtaposing at least the... Agent: Traskbritt, P.C.
20090305308 - Method for identifying cell-specific protein combination patterns: The present invention discloses a method for identifying cell-specific protein combination patterns of cell surfaces of circulating cells of the immune system of a human or animal for the identification of different stages of organ-specific chronic inflammatory diseases or tumour diseases comprising the following steps: a) providing a sample of... Agent: Tarolli, Sundheim, Covell & Tummino L.L.P.
20090305309 - Methods and compositions for detecting neoplastic cells: Methods and compositions for identifying neoplastic cells in a biological sample are provided.... Agent: Buchanan, Ingersoll & Rooney LLP
20090305307 - Methods for detecting targets: The present invention provides method and compositions for detecting target molecules present on cells and tissues. In particular, the methods involve adding primary antibodies such as scFv-targeted lactamase that are directed against a target of interest (e.g., cancer markers) to a tissue sample, followed by adding a lactam-containing compound and... Agent: Danisco US Inc. Attention: Legal Department
20090305310 - Methods for determining notch signaling and uses thereof: The invention relates, in part, to methods of determining Notch signaling in cells, tissues and/or subjects. The invention additionally relates, in part, to diagnostic assays for cell differentiation-associated diseases or conditions and for screening tools in research and clinical applications.... Agent: Wolf Greenfield & Sacks, P.C.
20090305311 - C4d/c4b standard for quantitative flow cytometry of humoral transplant rejection: The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d complement bound to a carrier consisting of erythrocytes or microparticles. The invention also concerns a method for analyzing in vitro... Agent: Sughrue Mion, PLLC
20090305313 - Diagnosis of candidiasis and candidemia or invasive candida infection: The use of an antibody to a C albicans cell wall antigen or to a solubilized phosphopeptidomannan (PPM) fraction of the cell wall of C albicans, or preferably a combination of an IgG2 antibody to a phosphopeptidomannan (PPM) fraction of the cell wall of C albicans, and an IgG1 or... Agent: Lynn E Barber
20090305312 - In vitro diagnostic method and kit for an aspergillus infection: The present invention relates to a method for the in vitro diagnosis of an Aspergillus infection by determining in the serum or plasma sample of a subject the quantity of antibodies directed against a combination of at least two of the ribonuclease (RNU), catalase (CA) and dipeptidylpeptidase V (DPPV) Aspergillus... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090305306 - Lectin complement pathway assays and related compositions and methods: This invention is related, in part, to assays for analyzing the lectin complement pathway (LCP) as well as to compositions and methods related thereto.... Agent: Wolf Greenfield & Sacks, P.C.
20090305314 - Upregulation of adamts4 protease activity for the treatment of alzheimer's disease: The invention provides methods of identifying compounds suitable for treating Alzheimer's disease and related conditions by means of modulation of ADAMTS4.... Agent: Merck And Co., Inc
20090305315 - Hubbed dual cannula device for closed container sampling systems: The present invention provides a hubbed dual cannula device for extracting a fluid sample from a closed container. The device comprises a housing hub, two substantially parallel needles, a venting valve and a hydrophobic membrane, and may be used effectively to extract a fluid sample from a sealed container, such... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090305316 - Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase: The present invention relates to a mutant protein of PQQ-dependent s-GDH characterized in that in at least one of the positions 122 and 124 the amino acid lysine is present, wherein these positions correspond to the amino acid positions known from the A. calcoaceticus s-GDH wild-type sequence (SEQ ID NO:... Agent: Barnes & Thornburg LLP (roche)
20090305317 - User interface for testing device: A testing system for testing an analyte in a fluid sample includes a user interface including a display for displaying information relating to measurements of health data and an input device for receiving information from a user relating to the health data. The testing system further includes an automarking feature... Agent: John C. Gatz Nixon Peabody LLP
20090305318 - Diagnostic tests of substance use disorders: The present invention relates to compositions and methods for identifying and quantifying platelet proteins. As certain behaviors and medical conditions alter the quantity of various platelet membrane proteins, the tools of the present invention are suitable for identification of biomarkers of these bodily states. For instance, the present invention provides... Agent: Morrison & Foerster LLP
20090305319 - Apparatus and methods for monitoring the status of a metabolically active cell: An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell... Agent: Morris Manning Martin LLP
20090305321 - Assays for allosteric modulators of g-protein coupled receptors (gpcrs): The present invention relates to G protein-coupled receptors (GPCRs) and allosteric modulators thereof. More specifically, the invention relates to allosteric modulators of GPCRs that interact at an intracellular binding site. It also relates to methods for designing or identifying small molecule allosteric modulators, including assays (such as competitive binding assays)... Agent: Fish & Richardson P.C.
20090305324 - Cytotoxic t-cell epitope peptides that specifically attack epstein-barr virus-infected cells and uses thereof: The present inventors introduced mRNAs for the Epstein-Barr virus proteins LMP1 and EBNA1 into antigen-presenting cells, and as a result, demonstrated that the cells induced Epstein-Barr virus-specific cytotoxic T cells. The present inventors also demonstrated that the cytotoxic T cells recognized epitope peptides presented via HLA-A*0206, HLA-Cw*0303, or HLA-Cw*0304, inhibited... Agent: Townsend And Townsend And Crew, LLP
20090305329 - Intracellular targeting of molecules: The present invention provides methods for intracellular and/or nuclear targeting of an agent capable of specifically binding to syndecan-4. The present invention further provides methods for the modification of the intracellular and/or nuclear targeting of said agent, as well methods for identifying compounds capable of modifying the syndecan-4 delivery pathway.... Agent: Hahn & Voight PLLC
20090305322 - Isotope detection and uses thereof: A method is disclosed for measuring the hydrogen and/or oxygen isotope ration of intracellular water in Escherichia coli cells and correlating the hydrogen and/or oxygen isotope ratio with the metabolic activity of the cell. A method is also disclosed for measuring the hydrogen and/or oxygen ratio of intracellular water via... Agent: Ballard Spahr LLP
20090305331 - Kits and methods for determining colon cleanliness: Method and kits for determining a cleanliness level of a colon of a subject are provided. The methods and kits of the present invention determine a parameter associated with colon cleanliness in a sample obtained from the subject and associate the parameter with the cleanliness level of the colon of... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090305323 - Lipidomics approaches for central nervous system disorders: The present invention has utilized the power of lipidomics to profile lipid metabolites and to characterize changes in lipid metabolism as they relate to CNS disorders. Lipidomic signatures can guide the development of diagnostic, prognostic and surrogate markers for CNS disorders; identification of new targets for drug design based on... Agent: Myers Bigel Sibley & Sajovec
20090305327 - Mass spectrometric determination of blood enzyme activity: The invention relates to the determination of the nature and strength of enzymatic activity in blood using mass spectrometric measurement of a profile of the reaction products. The determination of the enzymatic activity can be used for medical diagnostics, for example, and also to check the effectiveness of medication. The... Agent: Kohler Schmid Moebus
20090305332 - Method and apparatus for determining an analyte in a liquid sample: the concentration measurement is outputted by the evaluation apparatus after a selective further processing. Furthermore, the invention relates to an analytical apparatus for the determination of an analyte in a liquid sample as well as to a computer readable medium for performing function to determine an analyte in a liquid... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090305330 - Method and apparatus for the detection of living phytoplankton cells in water: The invention related to a method and an apparatus for detecting living phytoplankton cells and/or microorganisms in or out of water, particularly ballast water, bodies of water, sewage, or water in swimming and bathing devices. Said method is characterized by the following steps:—the variable fluorescence (Fv) is calculated by forming... Agent: Law Offices Of Robert F. Zielinski, LLC
20090305334 - Method for making a biological indicator for use with vaporous microbial deactivating agents: A biological indicator and method of making same. The biological indicator includes a carrier having a recess formed therein in order to restrict movement of an inoculum deposited onto the carrier. The inoculum includes microorganisms (e.g., bacterial spores) suspended in a suspension medium. The microorganisms are prepared by removing extraneous... Agent: Kusner & Jaffe Highland Place Suite 310
20090305325 - Method for preservation of human hematopoietic stem or progenitor cells: Maintenance of quiescent hematopoietic stem and progenitor cells (HSPC) in culture without the addition of exogenous growth factors is an important aspect in clinical hematology. A recent report described the ability of Flt3 receptor-interacting lectin (FRIL) in the maintenance of cord blood (CB) derived progenitors in vitro. Since FRIL is... Agent: The Webb Law Firm, P.C.
20090305320 - Method of detecting activation of notch signal transmission system: The purpose of the present invention is to provide detection methods of Notch signaling activation for detecting the activation of the Notch signaling in living cells simply and conveniently. The expression of a fluorescent protein Venus in a transgenic cell into which a vector having the fluorescent protein Venus gene... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090305328 - Method of improvement of organisms using profiling the flux sum of metabolites: The present invention relates to a method for improving an organism through the profiling of flux sum of metabolites, and more particularly to a method for screening key metabolites, the method comprises: plotting a profile between objective functions based on useful substance formation rate as a main function through an... Agent: Moore & Van Allen PLLC
20090305326 - Microfluidic device and method for coupling discrete microchannels and for co-culture: A microfluidic device and method is provided for coupling discrete channels and for co-culture. The microfluidic device includes first and second bodies. Each body has a bottom surface and defines a channel. The channel in each body includes an inlet and an outlet communicating with the bottom surface. A first... Agent: Wisconsin Alumni Research Foundation
20090305333 - Promoting axon regeneration in the adult cns through control of protein translation: Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.... Agent: Richard Aron Osman
20090305335 - Method for analysing a sample: This invention relates a method for analysing a biological sample by imaging, wherein sample processing and detection and optionally pre-treatment is performed in a single container. The invention further relates to a kit for use in said method.... Agent: Buchanan, Ingersoll & Rooney PC
20090305336 - Devices and methods for sampling microbial flora: Methods, devices and kits for sampling for a microorganism or microbial population on the digits of the extremities of an individual are described. In embodiments of the invention, the device comprises a container, such as a cell culture plate, with a growth medium that is delineated into multiple quadrants, which... Agent: Whyte Hirschboeck Dudek S.c. Intellectual Property Department
20090305337 - Sample processing system and method: Provided is a system and method for staining of one or more samples, including providing one or more self-contained sample processing receptacles, each of the one or more self-contained sample processing receptacles configured to be inserted into an auto-staining instrument; and enabling one of one or more staining procedures appropriate... Agent: Lee & Hayes, PLLC Margaret Anderson
20090305338 - Plant cell lines established from the medicinal plant veratrum californicum: The present invention relates to the field of plant secondary metabolites. More particularly plant cell lines are established from the medicinal plant Veratrum californicum. Said plant cell lines can be used for the production of cyclopamine and related steroid alkaloids and their precursors.... Agent: Traskbritt, P.C.
20090305340 - Altered peptide ligands of gad65: Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in humanized mice that express human HLA alleles associated with increased-risk of Type 1 diabetes.... Agent: Macmillan Sobanski & Todd, LLC
20090305344 - Chimeric alphavirus replicon particles: Chimeric alphaviruses and alphavirus replicon particles are provided, including methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules derived from one or more alphaviruses and structural proteins (capsid and/or envelope) from at least two or more alphaviruses. Methods of making, using, and therapeutic preparations... Agent: Novartis Vaccines And Diagnostics Inc.
20090305348 - Diagnostic test for vitamin b12: An isolated nucleotide sequence or fragment thereof encoding the porcine intrinsic factor, wherein the porcine intrinsic factor comprises an amino acid sequence having at least 85% amino acid sequence identity to an amino acid sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 6, and... Agent: Paul D. Yasger Abbott Laboratories
20090305346 - Engineered cleavage half-domains: Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.... Agent: Robins & Pasternak
20090305341 - Hcl-k1 polypeptide which offers collectin activity: Disclosed is the novel hCL-K1 polypeptide which offer collectin activity. This polypeptide consists of consecutive 271 amino acids set out in SEQ ID NO: 2 and does not bind to both maltose and N-acetylgalactosamine.... Agent: Marshall, Gerstein & Borun LLP
20090305343 - Method for expressing polypeptides in eukaryotic cells using alternative splicing: This invention relates to an expression cassette for expressing polypeptides in eukaryotic cells using alternative splicing. The expression cassette comprises in 5′ to 3′ downstream direction: a promoter; a sequence transcribed in a 5′ untranslated region (5′UTR); a donor splice site; an intron; a first acceptor splice site; a first... Agent: Young & Thompson
20090305347 - Pichia pastoris p1r1 secretion signal peptide for recombinant protein expression and pichia pastoris p1r1 and p1r2 anchor domain peptides for recombinant surface display: The present invention is directed to recombinant nucleic acid constructs comprising nucleic acid sequences encoding a Pichia pastoris PIR secretion signal peptide for secretion or an anchor domain peptide for surface display of a heterologous polypeptide. The present invention is further directed to methods for obtaining a heterologous polypeptide secreted... Agent: Thompson Coburn LLP
20090305345 - Polymerase: The present invention relates to an engineered polymerase characterized in that the polymerase exhibits an enhanced ability to process nucleic acid in the presence of environmental and biological inhibitors compared to wild type DNA polymerase.... Agent: Marshall, Gerstein & Borun LLP
20090305339 - Polypeptides with laccase activity: The invention relates to a new laccase from rumen, namely the RL5 laccase. In particular, the invention relates to a polypeptide comprising the amino acid sequence shown in FIG. 11 and comprising at least the amino acids No. 80 to No. 150 of the amino acid sequence shown in FIG.... Agent: Heslin Rothenberg Farley & Mesiti PC
20090305342 - Solubilization and purification of a target protein fused to a mutant maltose-binding protein: Methods and compositions are provided for increasing at least one of: (i) binding affinity of a target protein for a maltodextrin substrate and/or (ii) solubility of a target protein. The methods and compositions relate to a modified maltose-binding protein.... Agent: Harriet M. Strimpel, D. Phil.
20090305349 - Expression of soluble factor viii proteins in bacteria: The present invention provides enhanced methods of producing soluble Factor VIII proteins in microorganisms that have an oxidizing environment.... Agent: Nada Jain, P.C.
20090305350 - Gene differentially expressed in breast and bladder cancer and encoded polypeptides: The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named C35 that is overexpressed in human breast and bladder carcinoma. This invention also relates to C35 polypeptide, in particular... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090305352 - Activated collagen scaffold materials and their special fused active restoration factors: Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N-/C-terminus of cytokines, wherein the collagen-binding... Agent: Knobbe Martens Olson & Bear LLP
20090305351 - Method for preparing soluble and active recombinant proteins using pdi as a fusion partner: The present invention relates to a method for producing a recombinant protein capable of increasing expression rate of a target protein and also improving solubility and folding of the expressed target protein using a modified protein disulfide isomerase (PDI) as a fusion partner, and an expression vector containing the modified... Agent: Edwards Angell Palmer & Dodge LLP
20090305353 - Mutant firefly luciferase, gene, recombinant vector, transformant, and method for production of mutant firefly luciferase: (c) substitution of at least one of the amino acids at positions equivalent to positions 523 to 532 in the amino acid sequence of North American firefly luciferase with a positively-charged amino acid that has an isoelectric point higher than that of the amino acid to be substituted.... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090305354 - Process for preparing human g-csf: The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.... Agent: Ladas & Parry LLP
20090305355 - Method for syngas-production from liquefied biomass: The present invention relates to methods for syngas-production from biomass enabling the conversion of pre-treated biomasses having a high dry-matter content into electricity or oil-based products such as petrol, diesel, chemicals and plastics through the formation of syngas. The biomasses are converted into a biomass slurry having a suitable particle... Agent: Budde, Schou & Ostenfeld, A/s
20090305356 - Methods and apparatus for the use of ultrasonic energy to improve enzymatic activity during continuous processing: Described herein are methods and devices for increasing enzymatic activity during continuous processing by applying ultrasonic energy.... Agent: Foley & Lardner LLP
20090305357 - Chondroitin polymerase and dna encoding the same: A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090305358 - Dna vector production system: The invention discloses the production of double stranded DNA (dsDNA) vectors capable of delivering nucleic acids, including cDNA, antisense, ribozyme, and small interference RNA into cells. The invention also describes nucleic acid constructs as well as methods for the production of the dsDNA vectors.... Agent: Yung Nien Chang
20090305359 - Method for producing circular duplex polynucleotides from linear duplex polynucleotides and applications thereof: Methods are provided for making a circular duplex polynucleotide. Such methods can include providing a mixture of sequence specific linear duplex polynucleotides and denaturing and reannealing the polynucleotide mixture under conditions such that some of the polynucleotides form circular duplexes that comprise the desired polynucleotide.... Agent: Knobbe Martens Olson & Bear LLP
20090305360 - Saccharification enzyme composition and method of saccharification thereof: The present disclosure relates to a Bacillus subtilis alpha-amylase (AmyE) or its variants thereof. AmyE or its variants thereof may be used to more efficiently produce fermentable sugars from starch. Also disclosed are a composition comprising a glucoamylase and AmyE or variant thereof and a method of processing starch utilizing... Agent: Danisco US Inc. Attention: Legal Department
20090305361 - Starch process: The present invention relates to a process for enzymatic hydrolysis of granular starch into a soluble starch hydrolysate at a temperature below the initial gelatinization temperature of said granular starch.... Agent: Novozymes North America, Inc.
20090305362 - Process for preparing uronic acid oligosaccharides by extrusion: The present invention provides processes for the manufacture of uronic acid oligosaccharides using extrusion. The uronic acid polymers are extruded with an enzyme, under basic conditions (pH>9) and/or under high shear.... Agent: Bacon & Thomas, PLLC
20090305363 - Enhanced pyruvate to acetolactate conversion in yeast: A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase activity. Additional manipulations to improve flux to acetolactate are reduced pyruvate dehydrogenase activity and reduced glycerol-3-phosphate dehydrogenase activity. Production of compounds having... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090305364 - Microorganisms for the production of adipic acid and other compounds: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or... Agent: Mcdermott, Will & Emery
20090305365 - Fad4, fad5, fad5-2, and fad6, novel fatty acid desaturase family members and uses thereof: The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g.,... Agent: Connolly Bove Lodge & Hutz, LLP
20090305366 - Production of peracids using an enzyme having perhydrolysis activity: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.
20090305367 - Process for preparing long-chain dicarboxylic acids: The present invention particularly discovered strains that are capable of producing a long-chain dicarboxylic acid by culturing microorganisms belonging to Candida vini Candida entamophila, Candida blankii and Pichia farinosa which has the ability to produce a long-chain dicarboxylic acid in a liquid medium containing a straight-chain saturated hydrocarbon (tridecane) as... Agent: Ladas & Parry LLP
20090305368 - Method for producing hydroxycarboxylic acid by regenerating coenzyme: Hydroxycarboxylic acids are produced by using a microorganism that is improved in ability to regenerate oxidized-type nicotinamide adenine dinucleotide by being provided with an enhanced NADH dehydrogenase function by introducing a gene encoding NADH dehydrogenase into a microorganism.... Agent: Buchanan, Ingersoll & Rooney PC
20090305369 - Deletion mutants for the production of isobutanol: An E. coli host strain was engineered wherein genes adhE, IdhA, frdB, and pfIB were disrupted and novel butanol dehydrogenase gene, sadB, from Achromobacter xylosoxidans, was added to produce the isobutanol production host.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090305370 - Method for producing butanol using two-phase extractive fermentation: A method of making butanol from at least one fermentable carbon source that overcomes the issues of toxicity resulting in an increase in the effective titer, the effective rate, and the effective yield of butanol production by fermentation utilizing a recombinant microbial host wherein the butanol is extracted into specific... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090305371 - Method using infrared light for ethanol production: The present invention provides a method to optimize the fermentation culture of ethanol wherein said method comprises a device that allows enough illumination of the fermentation culture with a source or sources of light that emit a precise light wavelength with low power energy consumption and low heat generation. In... Agent: John J. Martinez Md. Jd.
20090305372 - Pre-treatment of biomass: The present invention relates to a method of pre-treatment of biomass, in order to improve the conversion of said biomass. The present invention also relates to a method of recovering chemicals used in said method. Further, the present invention relates to a method of converting pre-treated biomass into further products.... Agent: Antonius Hendriks
20090305373 - Trichoderma reesei glucoamylase and homologs thereof: The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for the glucoamylases, vectors and host cells incorporating the DNA sequences,... Agent: Danisco US Inc. Attention: Legal Department
20090305374 - Process for obtaining biochemicals in a zero-liquid discharge plant: A method is presented for the production of cellulosic ethanol, acetic acid and derivatives from the extract containing fibers and hemicelluloses after steam cooking of biomass in a host plant. The process is integrated with the host plant process to minimize the effect of loss of heat value from the... Agent: American Process Inc Steve Rutherford
20090305376 - Fermenter for producing biogas from organic material: The invention relates to a fermenter (10) for producing biogas from organic material, having a fermentation chamber (11) with a substantially round basal surface to receive fermentation material; arranged, in the peripheral region of the fermentation chamber, filling means (12) for substrate to be fermented; arranged, above the fermentation chamber,... Agent: Rankin, Hill & Clark LLP
20090305377 - Process and device for continuous liquefaction of organic solids: A method for the continuous liquefying of organic solids in a fermenter, wherein an outwardly directed flow of solids is produced in a dammed-up liquid, the solids are added in the lower region of the fermenter and the solid fermentation residues are essentially collected and removed below the level of... Agent: Kriegsman & Kriegsman
20090305375 - Sustainable supply of bioactive marine products: The identification and characterization of the sources of terpenes from the soft corals Leptogorgia minimata (LM, formerly Lophogorgia spp., Family: Gorgoniidae), Swifita exertia (SE, Family: Plexauridae), Iciligorgia schrammi (IS, Family: Anthothelidae), Eunicea fusca, Erythropodium caribaeorum or Plexaurella sp. through direct culture of microbial populations derived from coral homogenates.... Agent: Gregory A. Nelson Novak Druce & Quigg LLP
20090305378 - Integrated chemical process: A mineral carbonation process, characterised in that the silicate feedstock is thermally activated by using heat generated from the combustion of fuel prior to reacting the activated slurry feedstock with carbon dioxide.... Agent: Birch Stewart Kolasch & Birch
20090305379 - Digester system: A manure mixture within an anaerobic digestion tank stratifies to form a liquid effluent layer and a sludge layer. Liquid effluent from the liquid effluent layer is withdrawn from the tank through a height adjustable valve. The height adjustable valve is adapted to automatically adjust the position of its intake... Agent: Faegre & Benson LLP Patent Docketing - Intellectual Property
20090305380 - Electroporation of adherent cells with an array of closely spaced electrodes: Adherent cells and other membranous structures that are immobilized on a solid surface are transfected by electroporation in which the electric field is produced by a array of closely spaced electrodes positioned above the surface. Each electrode is substantially smaller in at least one lateral dimension than the dimensions of... Agent: Townsend And Townsend And Crew, LLP
20090305381 - Activated polymers binding biological molecules: The present invention relates to activated polymer substrates capable of binding functional biological molecules, to polymer substrates comprising bound and functional biological molecules, to devices comprising such substrates and to methods of producing them.... Agent: Amster, Rothstein & Ebenstein LLP
20090305382 - Alkoxy indolinone based protein kinase inhibitors: Alkoxy indolinone based acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.... Agent: Schwegman, Lundberg & Woessner, P.A.
20090305383 - Early detection of pathogens in blood: The present invention is a method of extracting infectious pathogens from a volume of blood including the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The fibrin lysis reagent is preferably composed of plasminogen and streptokinase frozen... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090305384 - Class ii human histone deacetylases, and uses related thereto: The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II histone deacetylase inhibitors.... Agent: Patent Correspondence Arnall Golden Gregory LLP
20090305385 - Novel cultured silkworm cells capable of highly efficient baculovirus production and protein production: Known cell lines derived from silkworm exhibit low propagation efficiency of BmNPV. Accordingly, systems using known culture cell lines derived from silkworms take a long time to establish recombinant viruses, and are not suitable for preparation of virus solutions with high titers. The present invention provides a cell line Bme21... Agent: Birch Stewart Kolasch & Birch
20090305386 - Low oxygen biologically mediated nutrient removal: The present invention is directed to a substantially odorless biologically mediated treatment process for solid and liquid organic wastes. The present invention also provides for a novel nutrient rich humus material produced from the biologically mediated treatment process. The bioconversion process of the present invention results from low electron acceptor... Agent: Kenyon & Kenyon LLP
20090305387 - Compositions and methods for cleaning surfaces: Cleaning compositions using the supernatant of lactic acid-producing bacteria are provided. Use of the compositions for disinfection/sanitization of surfaces are also disclosed.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20090305388 - Method for eliminating carbon dioxide from waste gases: A method for the elimination of carbon dioxide from waste gases includes the following steps. First, waste gases, which include carbon dioxide, are provided from a source for waste gases. Next, the waste gases are contacted with an absorbent composition that includes perfluorodecalin solution. The waste gases, especially the carbon... Agent: Barlow, Josephs & Holmes, Ltd.
20090305389 - Permeable membranes in film photobioreactors: Embodiments of the present invention include photobioreactors with membranes to introduce carbon dioxide into media contained within film photobioreactors. Such membranes can also be used to remove dissolved oxygen from the media. In some embodiments, one or more membrane tubes are welded into a plastic film photobioreactor to make a... Agent: Faegre & Benson LLP Patent Docketing - Intellectual Property
20090305390 - Method and installation for processing waste and producing methane: A method is provided for processing waste and producing methane, in which a chamber is filled with waste, in which it undergoes anaerobic degradation. According to the method, a large chamber and a small chamber are filled respectively with slightly organic waste and highly organic waste, and a liquid fraction... Agent: Fleit Gibbons Gutman Bongini & Bianco P.l.
20090305391 - Triphasic bioreactor and process for gas effluent treatment: A triphasic bioreactor for physico-chemically treating a gas is disclosed. The triphasic bioreactor comprises a reaction chamber with a liquid and biocatalysts in suspension in the liquid, for catalyzing a reaction between the gas and the liquid to obtain a treated gas and a solution containing a reaction product. A... Agent: Ware Fressola Van Der Sluys & Adolphson, LLP
20090305392 - Device for processing samples: Device for sample processing, particularly sample conditioning as well as for the preparation and/or optionally for implementing a sequential process for an analyte from a biological sample, said device comprising a module for receiving and/or outputting at least one sample vessel or process vessel, a module for transporting a process... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC
20090305393 - Apparatus, system, and method for in-situ measurements: The present invention relates to apparatus, systems and methods for performing in situ measurements, and, more particularly, to apparatus, systems and methods that can isolate a sample from a bulk fluid to measure characteristics of same without unwanted effects of perturbation in the bulk fluid.... Agent: Bayer Healthcare LLC
20090305394 - Dna chip for diagnosis of corneal dystrophy: The present invention relates to oligonucleotides for diagnosis of corneal dystrophy. More particularly, the present invention relates to oligonucleotides for detecting mutation of BIGH3 gene for diagnosis or corneal dystrophy including Avellino corneal dystrophy, which must be precisely diagnosed before vision correction surgery, and a DNA chip for diagnosis of... Agent: Moore & Van Allen PLLC
20090305395 - Reduction of the hook effect in membrane-based assay devices: A diagnostic test kit for detecting the presence or absence of a protease (e.g., aminopeptidase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the protease to release a compound. The kit also comprises a lateral flow... Agent: Dority & Manning, P.A.
20090305396 - Device for culture of cells or micro-organisms: This invention relates to a device intended for the culture of cells or micro-organisms, characterised by the fact that it comprises a chamber (100) composed of a tank (110) and a lid (150), adapted so that when in the closed state, it defines a sealed volume under a controlled pressure,... Agent: Blakely Sokoloff Taylor & Zafman
20090305397 - Cellular entity maturation and transportation systems: A device for transporting at least one cellular entity during culture or maturation, the device comprising a substrate having one or more wells, said one or more wells being adapted to hold a cellular entity in a fluid, lid means for preventing entry or exit of the cellular entity from... Agent: Goodwin Procter LLP Attn: Patent Administrator
20090305398 - Recombinant double-stranded rna phage, and use of the same: A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restricted to, vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues.... Agent: Whitham, Curtis & Christofferson & Cook, P.C.
20090305399 - Dna encoding osk1 toxin peptide analogs and vectors and cells for combinant expression: Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells... Agent: Amgen Inc.
20090305400 - Modified chaperonin 10: A novel granule dispersion composition which comprises water and, dispersed therein, a finely pulverized, sparingly water-soluble substance. The granule dispersion composition is prepared by dispersing in water a granular material which comprises a specific substance sparingly soluble in water, a polymer, and an oil and has an average particle diameter... Agent: Townsend And Townsend And Crew, LLP
20090305401 - Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics: The present invention provides a cell culture medium supplement comprising plasma-free platelet lysate and medium supplemented with this supplement. The present invention further provides a method for preparing the supplement comprising the steps of (a) preparing platelet rich plasma; (b) removing the plasma; and (c) lysing the platelets.... Agent: K&l Gates LLP
20090305402 - Methods and compositions for using zinc finger endonucleases to enhance homologous recombination: Described herein are methods of generating a genetically modified cell by providing a zinc finger endonuclease (ZFE) that includes an endonuclease domain that cuts DNA, and a zinc finger domain that includes a plurality of zinc fingers that bind to a specific nucleotide sequence within the endogenous chromosomal target DNA... Agent: Robins & Pasternak
20090305403 - Isolation and differentiation of adult hippocampal arctic squirrel neural stem cells: Neuronal stem cell lines derived from the Arctic Ground Squirrel, methods related to culturing and maintaining a neuronal stem cell line derived from the Arctic Ground Squirrel and a culture media required to maintain and differentiate a neuronal stem cell line derived from the Arctic Ground Squirrel is disclosed. Antibodies... Agent: Davis, Agnor, Rapaport & Skalny, LLC
20090305404 - Methods and compositions relating to blastomere-derived human embryonic stem cells: The invention provides methods for producing human embryonic stem cells from blastomeres with reduced or no animal cells or products, including no serum regardless of source and including xeno-free conditions, without compromising derivation efficiency.... Agent: Wolf Greenfield & Sacks, P.C.
20090305405 - Use of tgf beta superfamily antagonists and neurotrophins to make neurons from embryonic stem cells: This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected directly in monolayer culture on a suitable solid surface. The cells are either plated directly... Agent: Geron Corporation Attn. David J. Earp
20090305407 - Devices and methods for sampling biological fluids: Devices, instruments, systems and methods are provided in which a primary line that receives a biological fluid is selectively sampled by a plurality of collection chambers. Selective sampling occurs by selectively accessing the primary line and selective engagement of a sampling pump under control of a microprocessor. Further, the instrument... Agent: Biotech Beach Law Group , PC
20090305406 - Method of cultivation of human mesenchymal stem cells, particularly for the treatment of non-healing fractures, and bioreactor for carrying out this cultivation method: For the cultivation of the mesenchymal stem cells in the closed cultivation system for the clinical use in the field of orthopaedic surgery, a simple bioreactor is proposed. The bioreactor consists of a cassette system containing cultivation vessels with filters for securing the sterile exchange of gas and with aseptic... Agent: Notaro & Michalos P.C.
20090305408 - Method for the rapid expansion of antigen specific t-cell: The present invention encompasses a method for expanding an antigen specific T cell from a population of cells. The method of the present invention comprises contacting a population of cells with an MHC restricted antigenic peptide, a cytokine and a co-stimulatory signal. The invention also encompasses compositions and kits comprising... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20090305410 - Fluorescent compounds: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research... Agent: Wilson Sonsini Goodrich & Rosati
20090305409 - Liposome capable of effective delivery of given substance into nucleus: Disclosed is a non-viral vector capable of delivering a given substance into the nucleus of a target cell effectively even when the target cells is a undividable cell such as a dendritic cell. A bilamellar liposome having a first lipid membrane and a second lipid membrane successively from the outside,... Agent: Edwards Angell Palmer & Dodge LLP
20090305411 - Recombinant antibodies and immunoconjugates targeted to cd-22 bearing cells and tumors: Methods and compositions relating to anti-CD22 antibodies with high binding affinity, and immunoconjugates comprising the anti-CD22 antibody linked to a therapeutic agent such as a Pseudomonas exotoxin or a detectable label. The invention provides diagnostic methods, and means to inhibit the growth of malignant B cells.... Agent: Townsend And Townsend And Crew, LLP
20090305412 - Mechanically reversible gel: The present invention relates to a process for making a gel comprising combining a silanol species comprising at least two silanol groups per molecule and a hydrophilic hydroxyl species comprising at least two hydroxyl groups per molecule. The gel is capable of being converted to a liquid by application of... Agent: Knobbe Martens Olson & Bear LLP
20090305413 - Multipotent adult stem cells having an ability of oct4 expression derived from umbilical cord blood and method for preparing the same: The present invention relates to multipotent adult stem cells expressing Oct4, derived from umbilical cord blood (UCB) and also these cell are expressing CD29, CD31, CD44, simultaneously, a method for preparing the same, and more specifically to multipotent adult stem cells which are obtained by culturing umbilical cord blood-derived monocytes... Agent: Moore & Van Allen PLLC
20090305417 - Cell culture: A cell culture surface comprising a substrate and a polymer comprising a carboxylic acid monomer, wherein the carboxylic acid concentration of the polymer is from 3% to 33%.... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20090305415 - Method for preserving proliferation and differentiation potential of undifferentiated cells: A method for preserving proliferation and differentiation potential of undifferentiated cells, has steps of providing a culture carrier having a surface coated with a biological material selected from the group consisting of polysaccharide, sulfated polysaccharide and derivatives thereof; and inoculating and culturing the undifferentiated cells on the surface in the... Agent: Andrews Kurth LLP
20090305416 - Method for regulating proliferation of cells: A method for regulating proliferation of cells, has steps of providing a first culture system with a surface that is coated with a biological material; inoculating and culturing cells on the surface of the first culture system in an appropriate medium, such that the proliferation of the cells is preserved;... Agent: Andrews Kurth LLP
20090305414 - Methods of tissue engineering: An improved substrate for growing mono-layers of adherent-type cells and methods of growing tissue structures, ex vivo. The improved substrate, which comprises a silicon substrate coated with a photo cleavable polymer, releases adherent cells non-enzymatically. Also disclosed are methods for assembling complex layers of cells of various types.... Agent: Peter Giancana
20090305418 - Cell therapy method for the treatment of tumors: T cell responses are often diminished in humans with a compromised immune system. We have developed a method to isolate, stimulate and expand naïve cytotoxic T lymphocyte precursors (CTLp) to antigen-specific effectors, capable of lysing tumor cells in vivo. This ex vivo protocol produces fully functional effectors. Artificial antigen presenting... Agent: Philip S. Johnson Johnson & Johnson
20090305419 - Compositions for linking dna-binding domains and cleavage domains: Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases. Also described are methods of making and using compositions comprising these linkers.... Agent: Robins & Pasternak
20090305420 - Srsv detection kit: s
20090305421 - Recombinant vector for deleting specific regions of chromosome and method for deleting specific chromosomal regions of chromosome in the microorganism using the same: Disclosed herein are a recombinant vector for deletion of specific chromosomal regions and a method for deletion of targeted microbial chromosomal regions using the same. Specifically, the recombinant vector comprises an arabinose-inducible promoter; a gene encoding a protein involved in lambda (λ)-red recombination; a rhamnose-inducible promoter; and a gene encoding... Agent: Christie, Parker & Hale, LLP12/03/2009 > 140 patent applications in 69 patent subcategories.
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