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Chemistry: molecular biology and microbiology November recently filed with US Patent Office 11/09

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
11/26/2009 > 78 patent applications in 42 patent subcategories. recently filed with US Patent Office

20090291427 - Integration of sample storage and sample management for life science: Compositions and methods are disclosed for automated storing, tracking, retrieving and analyzing biological samples, including dry storage at ambient temperatures of nucleic acids, proteins (including enzymes), and cells using a dissolvable dry storage matrix that permits recovery of biologically active materials. RFID-tagged biological sample storage devices featuring dissolvable or dissociable... Agent: Seed Intellectual Property Law Group PLLC

20090291428 - Compositions and methods for the detection and treatment of poxviral infections: The invention encompasses an antibody that binds to and substantially inhibits the activity of at least one poxvirus complement inhibitor. Additionally, the application encompasses methods of detecting a poxvirus complement inhibitor and methods of decreasing the activity of a poxvirus complement inhibitor.... Agent: Polsinelli Shughart PC

20090291430 - Electrophoretic interactive spectral methods and devices for the detection and/or characterization of biological particles: Methods for identifying a biological particle in a sample medium include generating an Electrophoretic Quasi-elastic Light Scattering (EQELS) spectrum for the biological particle in the sample medium. The EQELS spectrum is compared to a reference database comprising a plurality of spectra, and each of the plurality of spectra correspond to... Agent: Myers Bigel Sibley & Sajovec

20090291429 - Substances causing differentiation: A DNA construct is described which contains a fusion gene under the control of a promoter. The fusion gene comprises at least one resistance gene and at least one reporter gene and is slightly toxic to a host cell transfected with that DNA construct. That DNA construct can be encoded... Agent: Knobbe Martens Olson & Bear LLP

20090291445 - Biomarker of lung injury and repair: The present invention resides in the discovery that circulating cytokaretin 5 (CK5) mRNA level correlates with the presence of a lung injury or disease as well as the severity or stage of the injury or disease. Diagnostic methods and kits are provided.... Agent: Townsend And Townsend And Crew, LLP

20090291450 - Caterpiller gene family: The present invention relates to a new family of structurally and functionally related nucleic acids and proteins, designed the CATERPILLER family, which is characterized by landmark structural motifs including a nucleotide binding domain and leucine-rich repeat domains.... Agent: Myers Bigel Sibley & Sajovec

20090291431 - Compositions and methods to detect legionella pneumophila nucleic acid: Compositions are disclosed as nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes specific for Legionella pneumophila 16S or 23S rRNA sequences or DNA encoding 16S or 23S rRNA. Methods are disclosed for detecting the presence of L. pnuemophila... Agent: Gen Probe Incorporated

20090291433 - Droplet-based nucleic acid amplification method and apparatus: The present invention relates to a droplet-based nucleic acid amplification method and apparatus. According to one embodiment, a method of amplifying a nucleic acid in a biological sample is provided, wherein the method includes: (a) providing a system comprising a droplet microactuator electronically coupled to and controlled by a processor... Agent: Ward And Smith, P.A.

20090291434 - Gene expression markers for colorectal cancer prognosis: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.... Agent: Heller Ehrman LLP

20090291432 - Genetic profiles associated with the 957c>t polymorphism in the drd2 gene: The present invention relates to a method for profiling an individual or group of individuals with respect to a neurological, psychiatric or psychological condition, phenotype or state, including a sub-threshold neurological, psychiatric or psychological condition, phenotype or state. More particularly, the present invention identifies a genetic profile associated with the... Agent: Knobbe Martens Olson & Bear LLP

20090291442 - Hspa1a as a marker for sensitivity to ksp inhibitors: The present invention relates to methods for predicting a response to treatment with a kinesin spindle protein inhibitor using heat shock protein 70, isoform A1a, also known as HSPA1a, as a marker for sensitivity to the kinesin spindle protein (KSP) inhibitors. Method are provided for predicting a response to treatment... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20090291449 - Method and apparatus to minimize diagnostic and other errors due to transposition of biological specimens among subjects: A method and apparatus for minimizing diagnostic errors due to transposition of biological specimens among subjects provides for independent biometric confirmation that a given specimen is from a given donor. In certain embodiments, a biological specimen confirmation kit comprises a portable and openable case housing components of the kit, at... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20090291446 - Method for confirming the presence of an analyte: The invention provides methods and kits for the rapid confirmation of an initial analyte test result. In a preferred embodiment, the process confirms the presence of a given microbial target in a mixed culture, or a mixed enrichment media, even when the competing organisms in the mix belong to related... Agent: Sheridan Ross PC

20090291440 - Method for synthesizing nucleic acid using dna polymerase beta and single molecule sequencing method: The present invention provides a nucleic acid synthesis method capable of continuously carrying out an extension reaction and a single molecule sequencing method capable of obtaining base information accurately at high speed. A method for synthesizing a nucleic acid, including the steps of: forming a complex of a target nucleic... Agent: Cheng Law Group, PLLC

20090291447 - Method of detecting colon cancer marker: It is intended to provide a non-invasive and convenient method of detecting a tumor marker for diagnosing colon cancer which is superior in sensitivity and specificity to the existing fecal occult blood test. More specifically speaking, a method of detecting a tumor marker for diagnosing colon cancer which comprises collecting... Agent: Frishauf, Holtz, Goodman & Chick, PC

20090291444 - Methods and materials for detecting and treating dementia: This document relates to methods and materials involved in detecting mutations linked to dementia (e.g., frontotemporal lobar degeneration). For example, methods and materials for determining whether or not a mammal is homozygous for a mutant T allele of rs5848 are provided. This document also relates to methods and materials involved... Agent: Fish & Richardson P.C.

20090291451 - Methods and primers for diagnosing idiopathic congenital central hypoventilation syndrome: The present invention provides assays and kits for diagnosing idiopathic congenital central hypoventilation syndrome. The present assays and kits focus on the second polyalanine repeat of the PHOX2b gene or gene product, which is normally 20 residues in length. A polyalanine repeat 25 to 33 residues in length is strongly... Agent: Barnes & Thornburg LLP

20090291438 - Methods for analysis of extracelluar rna species: The invention provides methods and kits for enabling quantitative or qualitative analysis of extracellular RNA species in non-cellular bodily fluids including plasma and serum to detect, infer, evaluate, or monitor cancer and other neoplasia or other diseases of interest.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090291436 - Methods for detecting nucleic acids indicative of cancer: The invention provides methods for screening tissue or body fluid samples for nucleic acid indicia of cancer or precancer.... Agent: Choate, Hall & Stewart LLP

20090291437 - Methods for targeting quadruplex sequences: Provided are quadruplex nucleotide sequences and methods for identifying interacting molecules.... Agent: Morrison & Foerster LLP

20090291452 - Micro-rna profiles associated with endometrial cancer development and response to cisplatin and doxorubicin chemotherapy: A method predicting of cancer chemoresponse of the population of cancer cells to the one or more chemotherapeutic agents. Our ability to treat patients with advanced stage and recurrent endometrial cancer is hampered by an incomplete understanding of the molecular basis of disease development and response to therapy. A novel... Agent: Smith Hopen, Pa

20090291439 - Phosphatases involved in the regulation of cardiomyocyte differentiation: m

20090291441 - Polypeptide, nucleic acid molecule encoding it and their uses: A polypeptide containing epitope of the amino acid sequence shown in SEQ ID NO:3 is provided, which is selected from the amino acid sequence of SEQ ID NO:3 and amino acids at 16-32 positions, amino acids at 1-30 positions, amino acids at 50-80 positions and amino acids at 17-200 positions... Agent: Occhiuti Rohlicek & Tsao, LLP

20090291448 - Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy: The application provides methods of prognosing and classifying lung cancer patients into poor survival groups or good survival groups and for determining the benefit of adjuvant chemotherapy by way of a multigene signature. The application also includes kits and computer products for use in the methods of the application.... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20090291435 - Thermal reaction device and method for using the same: Devices and methods for performing the relative concentration of a target in a sample, the sample containing both target and non-target components, the method performed by partitioning the sample into a large number of reaction volumes such that the target is concentrated relative to the non-target, and performing a detection... Agent: Townsend And Townsend And Crew, LLP

20090291443 - Use of highly parallel snp genotyping for fetal diagnosis: The present invention provides apparatus and methods for enriching components or cells from a sample and conducting genetic analysis, such as SNP genotyping to provide diagnostic results for fetal disorders or conditions.... Agent: Wilson, Sonsini, Goodrich & Rosati

20090291455 - Cynomolgus gp80 receptor and uses: Isolated polynucleotides encoding cynomolgus monkey gp80, polypeptides obtainable from expression of these polynucleotides, compositions, recombinant cells, methods of making and using these polynucleotides, polypeptides, and compositions are useful in development of human therapeutics.... Agent: Philip S. Johnson Johnson & Johnson

20090291454 - Detection method of bio material, fabrication method of chip for detection of bio mateiral, and chip for detecting of bio material: Provided are a method for detecting biomaterials, a method for fabricating a chip for biomaterial detection and a chip for biomaterial detection. The method for detecting biomaterials is characterized by comprising the steps of: (S1) immobilizing polydiacetylene liposomes onto a substrate; (S2) linking the polydiacetylene liposomes together and layering them... Agent: Kinney & Lange, P.A.

20090291456 - Method for diagnosing multiple sclerosis: Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090291453 - Method for testing alzheimer's disease by measuring degradation rate of b-amyloid in blood and diagnostic reagent: Provided is a method of testing Alzheimer's disease using serum or plasma as a sample. It is found that a β-amyloid peptide added to a blood sample is degraded. The degradation activity thereof was compared between the blood samples of normal subjects and Alzheimer's disease patients, and it is also... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090291457 - Re-targeted toxin conjugates: The present invention provides a method for designing a re-targeted toxin conjugate for use in treating a medical condition or disease. Also provided, is the use of said conjugates in the manufacture of a medicament for treating medical conditions or diseases. The conjugates include a Targeting Moiety, which directs the... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20090291458 - Method for determining the status of an individual: Methods of determining status of an individual based on the use of biological specimen and analysis of reference population of cells are described.... Agent: Wilson, Sonsini, Goodrich & Rosati / Nodality, Inc

20090291459 - Hybridoma capable of producing anti-dectin-1 monoclonal antibody: A hybridoma capable of producing a monoclonal antibody against dectin-1, and a monoclonal antibody which specifically reacts with dectin-1.... Agent: Sughrue-265550

20090291460 - Assay for transmissible spongiform encephalopathies: Provided is a novel method for detecting Transmissible Spongiform encephalopathies (TSE). The method comprises: selecting a sera sample from a subject to determine whether the subject has transmissible spongiform encephalopathy; and detecting antibodies that immune react with Spiroplasma proteins in the sample. The method detects antibodies in the individual sera... Agent: Juan J. Lizarraga

20090291461 - Method of selectively assaying adiponectin multimers: Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090291462 - Detection or quantification of aggrecan and its fragments: An immunoassay for aggrecan and/or aggrecan derived fragments comprises contacting a sample with an immunological binding partner which has specific binding affinity for the G2 domain of aggrecan at least when bearing keratan sulphate chains, and determining the existence or amount of specific binding of the immunological binding partner, which... Agent: Edwards Angell Palmer & Dodge LLP

20090291463 - Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system: A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090291468 - Method and device for monitoring medication usage: The present invention provides methods for detecting and quantifying metabolites in a biological sample by measuring the concentration of a test metabolite in the sample and comparing that concentration against the concentration of the reference metabolite; enabling accurate metabolite concentration measurements to determine aberrant drug usage patterns. Also disclosed is... Agent: Quarles & Brady LLP

20090291464 - Methods for measuring affinity substances in samples containing blood cell components: In the methods for measuring affinity substances using pearl chain formation of carrier particles, the use of carrier particles having a particular particle diameter enables carrier particles to be specifically counted even if blood cell components coexist. Whole blood samples can be used as samples to be measured without separating... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090291466 - Multinetwork nerve cell assay platform with parallel recording capability: A neuronal network analysis plate having alternating rows of recording wells and amplifying wells. The recording wells contain a neural cell network and a series of electrodes for recording the action potential signals of the neurons. The electrodes are connected to amplifiers in adjacent amplifying wells. The close proximity of... Agent: Jackson Walker LLP

20090291467 - Near infrared fluorophore for the selective labelling of membranes in cells: The present invention relates to anthraquinone derivatives which act as a fluorophore, to a process for producing said anthraquinone derivatives and their use as fluorophores for staining membranes in live or fixed cells.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090291465 - Screening method for identifying new drugs: A screening method for identifying new drugs A screening method for identifying a candidate to drug wherein said method 5 comprises the following steps: a) obtaining an expression vector which comprises a gene sequence codifying a naturally occurring pathogenic non-discriminating tRNA synthetase; b) transforming isolated mammalian cells with the expression... Agent: Berenbaum Weinshienk PC

20090291470 - Chondroitin synthase, method for producing the same and method for producing saccharide chain-extended chondroitin: A vector of the present invention has DNA encoding a protein or a product having the same effect as the protein, the protein containing an amino acid sequence from amino acid numbers 47 to 802 in SEQ. ID. NO:2. Expression of the DNA gives human chondroitin synthase. By using human... Agent: Kubovcik & Kubovcik

20090291469 - Compositions and methods for producing fermentation products and residuals: The present invention provides compositions and methods designed to increase value output of a fermentation reaction that yields a first product, intended for commercialization, such as ethanol, and a fermentation residual used, for example, as animal feed. The methods involve using microorganisms in the fermentation process that have been modified... Agent: Wilson, Sonsini, Goodrich & Rosati

20090291472 - Influenza nucleic acids, polypeptides, and uses thereof: Codon-optimized nucleic acids encoding influenza polypeptides and uses of the nucleic acids and polypeptides for inducing immune responses are provided herein.... Agent: Fish & Richardson PC

20090291471 - Novel beta-galactoside alpha 2,6-sialyltransferase, gene coding for the transferase and process for producing the same: The present invention provides a novel β-galactoside-α2,6-sialyltransferase having high productivity and/or high activity, and a nucleic acid encoding the sialyltransferase. The present invention also provides a microorganism producing the sialyltransferase. The present invention further provides a vector carrying a nucleic acid encoding the sialyltransferase, and a host cell transformed with... Agent: Birch Stewart Kolasch & Birch

20090291473 - Method for production of recombinant human fsh: Disclosed is a method for production of recombinant human FSH in high yield and a high purity. The method comprises the steps of: (a) culturing recombinant human FSH-producing mammalian cells in a serum-free medium, (b) collecting culture supernatant, (c) subjecting the culture supernatant to cation-exchange column chromatography, (d) dye affinity... Agent: Millen, White, Zelano & Branigan, P.C.

20090291474 - Collagen-like polypeptides and encoding polynucleotides: Provided herein are isolated polynucleotides encoding collagen-like polypeptide domains and the encoded polypeptides. In one such polypeptide, at least a portion of the encoded collagen-like polypeptide domain is in the form of Gly-X-Y triads, where X and Y symbolize individual amino acids; X is proline in at least 20% of... Agent: Knobbe Martens Olson & Bear LLP

20090291475 - Sequence amplification with linear primers: The present disclosure relates to the amplification of target nucleic acid sequences for various sequencing and/or identification techniques. The use of these primers, as described herein, allows for the reduction in the amplification of nonspecific hybridization events (such as primer dimerization) while allowing for the amplification of the target nucleic... Agent: Knobbe Martens Olson & Bear LLP

20090291476 - Resistance of plants to biotic and abiotic stresses by overexpression of protochlorophyllide oxidoreductase c and its isoforms: A process for the construction of plant transformation vector comprising: digesting a binary vector pCAMBIA 1304 with EcoRI and Sal I; subjecting the digested binary vector to the step of end filling by Klenow; re-ligating the said binary vector by known method; obtaining CaMV 35 8 promoter cassette with Ω... Agent: The Webb Law Firm, P.C.

20090291477 - Methods for obtaining crystals of a basic amino acid hydrochloride: The present invention provides a method for separating and obtaining a basic amino acid hydrochloride from a basic amino acid fermentation broth or an enzyme reaction solution which enzyme reaction is catalyzed by viable microbial cells which are able to produce a basic amino acid, each containing sulfate ions, wherein... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090291478 - Method for producing an l-amino acid: An L-amino acid is produced by culturing a bacterium of the Enterobacteriaceae family which has an L-amino acid-producing ability in a medium containing fatty acids as the carbon source, particularly fatty acids which have been subjected to emulsification or homogenization, to thereby produce and accumulate the L-amino acid in a... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090291479 - Manipulation of acyl-coa binding protein expression for altered lipid production in microbial hosts: Acyl-CoA binding protein [“ACBP”] binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. This protein is expected to play an important role in altering lipid production in oleaginous microbial organisms. Knock-out of the protein in the oleaginous yeast, Yarrowia... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090291480 - Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production: The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing such enzymes, as well as methods of their use, for example to produce malonyl semialdehyde and downstream products thereof, such as 3-hydroxypropionic acid and derivatives thereof.... Agent: Cargill, Incorporated

20090291481 - Removal of fermentation inhibiting compounds from citrus waste using solvent extraction and production of ethanol from citrus waste: The present invention relates to novel processes for producing ethanol from citrus waste using suitable solvent extractions to reduce the presence of fermentation inhibiting compounds, such as limonene, from citrus waste. The extraction can be performed before or after the polysaccharides present in aqueous mixtures comprising citrus waste are converted... Agent: Feldmangale, P.A.

20090291482 - Ethanol production from citrus waste through limonene reduction: The present invention relates to processes for producing ethanol from citrus waste wherein the level of fermentation-inhibiting compounds found in citrus waste or the complex polysaccharide or sugars derived therefrom is reduced using a pre-fermentation treatment step to lower the level of fermentation-inhibiting compounds to the fermentation feedstock.... Agent: Feldmangale, P.A.

20090291483 - Enzyme granulate: The invention relates to an enzyme-containing granule comprising a core unit and a shell unit, wherein the core unit comprises the enzyme and is enclosed in a shell unit which is substantially enzyme-free, the ratio between the diameter of the granule and the diameter of the core unit being at... Agent: Novozymes North America, Inc.

20090291484 - Method to enhance production of paralytic shellfish toxins from dinoflagellate cultures: A simple solid phase extraction (SPE) method for continuous sequestering and concentration of waterborne cues from sea water conditioned with aquatic source organisms that induce toxin formation in dinoflagellates, and a method of increasing this toxin formation.... Agent: Lynn E Barber

20090291485 - Apparatus and method for optimizing photosynthetic growth in a photo bioreactor: A system and methods for enhancing mass production of algae, diatoms or other photosynthetic organism is described. The system and methods are useful in applications such as energy production, fuels, foods, pharmaceuticals, plastics, and CO2 fixation. The system and methods involve the use of a submersed rotating pole(s) on which... Agent: Wesley B. Ames

20090291486 - Organ preservation apparatus and methods: A transportable organ preservation system that substantially increases the time during which the organ can be maintained viable for successful implantation into a recipient is disclosed. A chilled oxygenated nutrient solution can be pumped through the vascular bed of the organ after excision of the organ from the donor and... Agent: Mcandrews Held & Malloy, Ltd

20090291487 - Thermocycling device: The invention relates to a thermocycler module for heating and/or cooling of a thermocycling device comprising a thermal switch, a heating block and a heat sink. The thermal switch comprises a thermoconducting liquid, e.g. a magnetic fluid or a liquid metal, and a stimulating unit, e.g. a magnetic unit or... Agent: Roche Molecular Systems, Inc. Patent Law Department

20090291488 - Microorganism testing device and microorganism testing chip: A microorganism testing device includes: an analysis chip that includes a fluid specimen container, a reaction container for causing the fluid specimen to react with a reagent solution, a microorganism detection flow path, and an alignment reagent container for holding an alignment reagent to be used in an alignment work... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090291489 - Disposal apparatus of food wastes: Disclosed is a disposal apparatus of food wastes. The disposal apparatus includes a reactor for permitting the food wastes and microbes for decomposing the food wastes to be contained therein; an agitator mounted inside the reactor for mixing the food wastes and the microbes; an air inlet connected with the... Agent: Mcdermott Will & Emery LLP

20090291490 - Photo-bioreactor: A photo-bioreactor may be constructed from multiple layers of polymer film arranged to provide a cultivation region and an energy modulation region. The energy modulation region may include a phase change material. A plurality of photo-bioreactors may be positioned in series with one another and arranged in a variety of... Agent: Philip D. Lane

20090291491 - Retroviral vectors: Retroviral vector production systems for producing lentivirus-based vector particles which are capable of infecting and transducing non-dividing target cells, wherein one or more of the auxiliary genes such as vpr, vif, tat, and nef in the case of HIV-1 are absent from the system. The systems and resulting retrovirus vector... Agent: Frommer Lawrence & Haug

20090291492 - Method for forming organ: A method for forming an organ and/or tissue from undifferentiated cells derived from a vertebrate animal in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid X receptor ligand (e.g., a retinoic acid X receptor agonist or... Agent: Greenblum & Bernstein, P.L.C

20090291493 - Human immunodeficiency virus-neutralizing antibodies with improved breadth and potency: The present invention provides an antibody to human immunodeficiency virus (HIV) envelope glycoprotein that can recognize one or more strains of HIV, wherein the epitope of HIV recognized by the antibody is inducible, and wherein the antibody binding to the epitope is enhanced by the presence of CD4 and the... Agent: Leydig, Voit & Mayer, Ltd.

20090291494 - Differentiation of multi-lineage progenitor cells to pancreatic cells: Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described, as well as methods of differentiating the progenitor cells into pancreatic cells.... Agent: Fish & Richardson P.C.

20090291495 - Neural cell populations from primate pluripotent stem cells: This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected directly in monolayer culture on a suitable solid surface. The cells are either plated directly... Agent: Geron Corporation Attn. David J. Earp

20090291496 - Neural stem cell isolates from the dental papillary annulus of developing teeth: Multipotent cranial neural crest stem cells and non-lineage committed precursor cells are described. The neural crest cells are capable of self-renewal, of being cultured into clonal spheroids including neurospheres, and of differentiation into neurons or other neuroepithelial cells. The non-lineage committed precursors are capable of differentiation into neurons, astrocytes and... Agent: Maginot, Moore & Beck, LLP Chase Tower

20090291498 - Biodegradable t-cell activation method: A biodegradable device for activating T-cells includes a biodegradable support and a binder attached to the biodegradable support, the binder having reactivity to one or more agents capable of binding to a T-cell surface antigen.... Agent: Westman Champlin & Kelly, P.A.

20090291497 - Sirna targeting transducin (beta)-like 3 (tbl3): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20090291499 - Biological tissue-reinforcing material, method of producing the same, use of the same, and method of culturing cells: A method of producing a biological tissue-reinforcing material, which is applicable to a site required to be reinforced and which enables to improve the working properties for transplantation, comprising the step S1 of coprecipitating ammonium hydrogen phosphate with calcium nitrate in the presence of sulfuric acid.... Agent: Scully Scott Murphy & Presser, PC

20090291500 - Production process of an organic/inorganic composite hydrogel, cell culture substrate comprising an organic/inorganic composite hydrogel, and antifogging material comprising a dried organic/inorganic composite hydrogel: The present invention provides a production process of an organic/inorganic composite hydrogel, which demonstrates superior mechanical properties, by uniformly dispersing a clay mineral in an organic polymer over a wide range of clay mineral content, and a dried form thereof, to be produced easily in a short period of time.... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20090291501 - Rapid dissolve media: A method for producing a palletized material includes mixing a media powder with a treated water (100), the treated water comprising an additive for substantially preventing bacterial contamination, pouring the mixture of media powder and halogenated water on a non-binding surface (102), spreading the mixture into a wafer (103), Drying... Agent: F. Chau & Associates, LLC

20090291502 - Gene injection apparatus and gene injection method: A gene injection apparatus for injecting a gene into a cell held on a substrate, includes a needle unit. The needle unit includes a fine needle to be inserted into the cell immersed in a culture medium in which the gene is dispersed, and a flexible support part configured to... Agent: Scully Scott Murphy & Presser, PC

20090291503 - Recombinant adeno-associated virus production: The present invention relates to methods and materials for recombinant adeno-associated virus production. More particularly, the invention relates to use of recombinant adenovirus encoding adeno-associated virus protein in recombinant adeno-associated virus production methods.... Agent: Marshall, Gerstein & Borun LLP

20090291504 - Cre complementation using leucine zipper: Cre activity is effectively reconstituted from two modified, inactive Cre fragments, both in cell culture and in transgenic mice. Cre reassociation was facilitated by fusing fragments separately to peptides that can form a tight anti-parallel leucine zipper. The co-expressed Cre fusion fragments showed substantial activity in cultured cells. Also disclosed... Agent: Fulbright & Jaworski L.L.P.

  
11/19/2009 > 78 patent applications in 42 patent subcategories. recently filed with US Patent Office

20090286220 - Hypothermic preservation of biological tissues and cells: A method for hypothermic preservation of biological tissue for later recovery to a viable state includes flushing the biological tissue with a gas mixture of sulfur hexafluoride or xenon and oxygen. The sulfur hexafluoride or xenon is in a concentration in the mixture between about 75 mole percent to 95... Agent: Louis Ventre, Jr

20090286221 - Device comprising a container system for a bodily fluid: The invention relates to a device for separating a bodily fluid, in particular blood platelet concentrate, into fractions under centrifugal force. The device comprises a flexible container system which comprises at least a first container for the fluid to be separated and a second container for a separated fraction, wherein... Agent: The Webb Law Firm, P.C.

20090286225 - Method and apparatus for bacteriophage-based diagnostic assays: Bacteriophage are combined with a test sample in an incubator, and the bacteriophage-exposed test sample is conjugated and applied to a sample pad in contact with a lateral flow strip to determine the presence or absence of a target bacterium. The conjugation may be performed in the sample pad or... Agent: Patton Boggs LLP

20090286232 - Method and apparatus for enhanced sensitivity in bacteriophage-based diagnostic assays: A method of determining the presence or absence of a target microorganism in a sample to be tested, the method comprising: (a) combining with the sample an amount of bacteriophage capable of attaching to the target microorganism to create a bacteriophage-exposed sample; (b) providing conditions to the bacteriophage-exposed sample sufficient... Agent: Patton Boggs LLP

20090286224 - Method for producing human antibodies with properties of agonist, antagonist, or inverse agonist: A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of... Agent: Bacon & Thomas, PLLC

20090286223 - Methods and kits for in situ measurement of enzyme activity and amount using single measurement system: Disclosed are methods and kits for measuring in situ the activity and amount of an enzyme in a sample using a single measurement system. The method includes the steps of: (a) contacting a sample to a capturing agent having the capacity to bind to the enzyme to be analyzed and... Agent: Sughrue Mion, PLLC

20090286228 - Methods, devices, kits and compositions for detecting roundworm: Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a mammalian sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090286229 - Methods, devices, kits and compositions for detecting roundworm: Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090286230 - Methods, devices, kits and compositions for detecting roundworm: Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090286231 - Methods, devices, kits and compositions for detecting roundworm, whipworm, and hookworm: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090286227 - Methods, devices, kits and compositions for detecting whipworm: Methods, devices, kits and compositions for detecting the presence or absence of whipworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of whipworm in a fecal sample from a mammal that may... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090286222 - Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial... Agent: Peter G. Carroll Medlen & Carroll, LLP

20090286226 - Simple membrane assay method and kit: A simple membrane assay method for detecting or quantitating an analyte in a specimen sample using an assay device equipped with a membrane bound with a capture-substance to capture the analyte, including the steps of filtering a specimen sample using a filter, dropping the filtrate onto said membrane and detecting... Agent: Nixon & Vanderhye, PC

20090286240 - Biomarkers overexpressed in prostate cancer: Biomarkers are identified by analyzing gene expression data using support vector machines (SVM) to rank genes according to their ability to separate prostate cancer from normal tissue. Proteins expressed by identified genes are detected in patient samples to screen, predict and monitor prostate cancer.... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20090286243 - Compositions and methods for spinocerebellar ataxia: Mutations in the KCNC3 (Kv3.3) voltage-gated potassium channel gene result in spinocerebellar ataxia.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090286237 - Diagnostic kits and methods for oesophageal abnormalities: The invention relates to kits and methods for aiding the diagnosis of Barrett's oesophagus or Barrett's associated dysplasia. Preferred is a method comprising assaying cells from the surface of a subject's oesophagus for a non-squamous cellular marker, wherein detection of such a marker indicates increased likelihood of the presence of... Agent: Edwards Angell Palmer & Dodge LLP

20090286251 - Enzyme reagents for amplification of polynucleotides in the presence of inhibitors: Compositions and methods are provided for amplifying polynucletoides from samples containing inhibitors that normally inhibit amplification using an enzyme blend containing a plurality of polymerases. The ability to amplify polynucleotides efficiently in the presence of inhibitors allows the enzyme reagent to be used in both routine amplification and real-time amplification... Agent: Harriet M. Strimpel, D. Phil.

20090286244 - Fluorescent color markers: The invention provides a yeast-enhanced red fluorescent protein. In an embodiment of the invention, the yeast-enhanced red fluorescent protein is monomeric and is expressible in Candida albicans. The invention also provides a novel visible color marker for plasmid expression in yeast, particularly Saccharomyces cerevisiae and Candida albicans.... Agent: Kenyon & Kenyon LLP

20090286254 - Gene silencing: Methods are disclosed for screening for the occurrence of gene silencing (e.g., post transcriptional gene silencing) in an organism. Also provided are methods for isolating silencing agents so identified.... Agent: Morrison & Foerster LLP

20090286253 - Genetic loci associated with sclerotinia tolerance in soybean: The invention relates to methods and compositions for identifying soybean plants that are tolerant, have improved tolerance or are susceptible to Sclerotinia sp. infection (the causative agent of white mold). The methods use molecular genetic markers to identify, select and/or construct disease-tolerant plants or identify and counterselect disease-susceptible plants. Soybean... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pioneer Hi-bred

20090286234 - Il10 snp associated with acute rejection: The present invention concerns a method for the prediction of acute renal transplant rejection by detecting a poly-morphism in the promoter region of the IL 10 gene, optionally in combination with polymorphisms of the MDR1 and IMPDH2 genes which were found to be associated with this disease.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20090286249 - Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences: The present invention provides compositions, kits and methods for the selective hybridization and capture of a specific target nucleic acid. The specific target nucleic acid may be present in a heterogeneous mixture of nucleic acids. Selective hybridization and capture provides a target nucleic acid that is substantially free of non-target... Agent: Gen Probe Incorporated

20090286250 - Incorporating soluble security markers into cyanoacrylate solutions: Methods for authenticating an article with a cyanoacrylate solution comprising a water soluble security marker compound are described. The methods for producing a nucleophilic security marker/cyanoacrylate solution as well as methods for labeling an item and detecting the nucleophilic security marker/cyanoacrylate from an item being authenticated are also described. A... Agent: KerrIPGroup, LLC Michael A. Kerr

20090286235 - Mdr1 snp in acute rejection: The present invention concerns a method for the prediction of acute renal transplant rejection by detecting a polymorphism in exon 26 of the MDR1 gene, optionally in combination with polymorphisms of the IMPDH2 and IL 10 genes which were found to be associated with this disease.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20090286236 - Method for detecting cell proliferative disorders: The present invention relates to the detection of a cell proliferative disorder associated with alterations of microsatellite DNA in a sample. The microsatellite DNA can be contained within any of a variety of samples, such as urine, sputum, bile, stool, cervical tissue, saliva, tears, or cerebral spinal fluid. The invention... Agent: Banner & Witcoff, Ltd.

20090286233 - Method for diagnosing diabetic retinopathy by single nucleotide polymorphism, dna fragment thereof, and primer thereof: Disclosed is a method for diagnosing diabetic retinopathy by a single nucleotide polymorphism of VEGF and its receptor.... Agent: Foley & Lardner LLP

20090286239 - Method of detecting individual encapsulated influenza viruses, primer set for the detection and kit for the detection: The method of detecting Haemophilus influenzae Types a, c, d, e and f of the present invention comprises: amplifying capsulation locus region II derived from each of Haemophilus influenzae Types a, c, d, e and f, using a LAMP primer set comprising one or more types of primers each having... Agent: Birch Stewart Kolasch & Birch

20090286255 - Methods for assessing efficacy of chemotherapeutic agents: Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the ability of a chemotherapeutic to destroy cells and the genetic propensity of those cells for resistance. Results obtained using methods of the invention provide... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090286248 - Methods for determining drug responsiveness: The invention provides a diagnostics assay for measuring the responsiveness to a drug by comparing the mRNA levels of a gene that responds to the drug, such as a steroid, to the MRNA levels of a gene that does not respond to the drug. Methods according to the invention are... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20090286246 - Methods for identifying compounds that affect expression of cancer-related protein isoforms: Provided herein are methods for screening compounds for their ability to modulate the expression of certain isoforms of proteins that are associated with cancer, such as isoforms of proteins that participate in Wnt signaling in cancer cells.... Agent: Fish & Richardson P.C.

20090286238 - Methods to monitor, diagnose and identify biomarkers for psychotic disorders: A stimulated or non-stimulated T-cell sample can be used to diagnose or monitor a psychotic disorder, to identify a biomarker, or as to test a considerate as a potential therapeutic agent.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090286242 - Microrna expression profiling and uses thereof: Provided are methods and reagents for obtaining microRNA expression profiles in selected cell populations or sub-populations, such as stem cell or progenitor cell populations, and using such microRNA expression profiles for cell characterization, isolation/purification, and/or reinforcement of cell fate specification, both in research & development, and in therapeutic applications. Also... Agent: Wilmerhale/cold Spring Harbor Laboratory

20090286247 - Novel nucleic acid base pair: A novel artificial nucleic acid base pair which is obtained by forming a selective base pair by introducing a group having steric hindrance (preferably a group having steric hindrance and static repulsion and a stacking effect) and can be recognized by a polymerase such as DNA polymerase; a novel artificial... Agent: Edwards Angell Palmer & Dodge LLP

20090286252 - Nrif3, novel co-activator for nuclear hormone receptors: Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is useful in development/implementation of high throughput screens to identify novel thyroid hormone receptor (TR) and retinoid X receptor (RXR) agonists... Agent: Darby & Darby P.C.

20090286241 - System and method for detecting a gene mutation: A system for detecting a gene mutation encompasses a spectrum generation mechanism configured to acquire an amplified product containing the specific site sandwiched by recognition sites of a restriction enzyme by using a recognition site introduction-oriented primer, and to generate a mass spectrum of an oligonucleotide fragment, which is cut... Agent: Sughrue Mion, PLLC

20090286245 - Two slow-step polymerase enzyme systems and methods: Compositions, kits, methods and systems for nucleotide sequencing comprising producing polymerase reactions that exhibit two kinetically observable steps within an observable phase of the polymerase reaction. Two slow step systems can be produced, for example, by selecting the appropriate polymerase enzyme, polymerase reaction conditions including cofactors, and polymerase reaction substrates... Agent: Pacific Biosciences Of California, Inc.

20090286258 - Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry: m

20090286256 - Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides: The present disclosure relates to isolated human autoantibodies and assays and kits for detecting human autoantibodies reactive with at least one natriuretic peptide or natriuretic peptide fragment in a test sample.... Agent: Paul D. Yasger Abbott Laboratories

20090286257 - Water soluble nanocrystalline quantum dots capable of near infrared emissions: A novel quantum dot capable of near infrared emissions at wavelengths of 750-1100 is made by forming solid solutions of metal sulfide, metal selenide or metal sulfide selenide by incorporating a suitable amount of an additional metallic element or elements to provide an emission wavelength in the range of 750... Agent: Knoble, Yoshida & Dunleavy

20090286259 - Screening method for gpcr ligands: This invention relates to a method of identifying a compound capable of binding to a target domain of a G-protein coupled receptor comprising the steps of: (a) providing a receptor comprising said target domain and a first group linked to said target domain; (b) bringing into contact said receptor of... Agent: Reed Smith LLP

20090286264 - Imaging of immunomagnetically enriched rare cells: A method for removing excess unbound ferrofluid and imaging immunomagnetically enriched circulating tumor cells is provided. A vessels having a preformed grooves in the viewing surface is optimally designed for cell alignment and imaging. After separating the unbound particles by centrifugation, an externally-applied force is applied to transport magnetically responsive... Agent: Philip S. Johnson Johnson & Johnson

20090286262 - Nucleic acid, polypeptide and its use: Novel chimeric proteins functional to screen for sweet taste modulators, the corresponding nucleic acid sequences, expression vectors, transfected host cells, and screening methods for modulators and enhancers of the sweet taste response employing the aforementioned are provided.... Agent: Curatolo Sidoti Co., Lpa

20090286263 - Skin tape stripping: a non-invasive diagnostic strategy for dermal exposure to cytotoxic compounds: A non-invasive method for determining a subject's dermal exposure to an agent employing an immunohistochemical procedure on a skin strip applied to an exposed area on the subject's person and detecting agent adduct thereon.... Agent: United States Army Medical Research And Material Command Mcmr-za-j

20090286265 - Cripto blocking antibodies and uses thereof: The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies... Agent: Lahive & Cockfield, LLP / Biogen Idec Floor 30, Suite 3000

20090286260 - Myeloperoxidase detection in diagnosis and prognosis of hematopoietic disorders: The present invention relates to the diagnosis of hematopoietic disorders and to determining the prognosis of patients affected by such disorders. The methods generally comprise determining a level of myeloperoxidase in a body fluid sample from the individual and using the level as a factor for diagnosing the disorder in... Agent: Foley & Lardner LLP

20090286261 - Method for assaying compounds or agents for ability to displace potent ligands of hematopoietic prostaglandin d synthase: An exemplary embodiment may be directed to a fluorescence polarization assay that screens compounds or agents for their affinity to hematopoietic prostaglandin D synthase (H-PGDS) based on their ability to displace a fluorophore-containing detection analyte bound to an enzyme comprising the primary amino acid sequence of H-PGDS. Another exemplary embodiment... Agent: Macmillan Sobanski & Todd, LLC

20090286268 - Assays for cancer patient monitoring based on levels of analyte components of the plasminogen activator system in body fluid samples: The present invention describes clinically and medically important methods of examining, screening over time, and monitoring the outcome of a cancer patient who is undergoing treatment or therapy for his or her disease. More specifically, the invention provides a method of monitoring the progression of disease, or the effectiveness of... Agent: Leona L. Lauder

20090286266 - Method of determining the sex of birds, reptiles and mammals using steroid hormones: The present invention consists in the design of an ELISA test, specific to determine through fecal feces, urine or plasma of birds, reptiles and mammals, the levels of concentration of the hormone testosterone as an indicator of masculine sex in these species for a better handling of the reproduction and... Agent: Defillo & Associates, Inc.

20090286267 - Methods for determining drug responsiveness: The invention provides a diagnostics assay for measuring the responsiveness to a drug by comparing the protein levels of a gene that responds to the drug, such as a steroid, to the protein levels of a gene that does not respond to the drug. Methods according to the invention are... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20090286269 - Method for detecting prp using at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand: A method for detecting PrP in a biological human or animal sample that may contain said PrP. The method is characterized in that it uses a molecule containing at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand selected from macrocyclic... Agent: Oliff & Berridge, PLC

20090286270 - Method for treating pervasive development disorders: A method of utilizing the chymotrypsin level of an individual as a measure of the success of secretin, other neuropeptides, and peptides or digestive enzyme administration to such individuals, and in particular, as a prognosticative of potential secretin, other neuropeptides, peptides, and digestive enzyme administration for persons having ADD, ADHD,... Agent: Fish & Richardson P.C.

20090286272 - Biomarkers for niemann-pick c disease and related disorders: Methods for screening or diagnosing subjects for disorders involving accumulation of one or more oxysterols such as cytotoxic oxysterol accumulation, Niemann-Pick C(NPC) disease, lysosomal storage diseases, cholesterol trafficking diseases, and neurodegenerative diseases. Also provided are methods for methods for screening or diagnosing subjects (including infants and neonatal subjects) for NPC... Agent: Harness, Dickey & Pierce, P.L.C

20090286274 - Method of monitoring live cells: t

20090286276 - Methods for predicting a patient's response to egfr inhibitors: The present invention provides methods for individualizing chemotherapy for cancer treatment, and particularly for evaluating a patient's responsiveness to one or more epidermal growth factor receptor (EGFR) inhibitors prior to treatment with such agents. Particularly, the invention provides an in vitro chemoresponse assay for predicting a patient's response to an... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090286271 - Methods of diagnosing and treating complications of pregnancy: Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-β1, TGF-β3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity. Also disclosed are methods of diagnosing a pregnancy... Agent: Clark & Elbing LLP

20090286278 - Multi-layer cell encapsulation for tissue engineering: A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide... Agent: Banner & Witcoff, Ltd.

20090286277 - Prognostic method: m

20090286275 - Two-photon probe for real-time monitoring of intracellular free zinc ions, method for preparing the probe and method for real-time monitoring of intracellular free zinc ions using the probe: wherein R is H or OCH3. The two-photon probe has high selectivity for Zn2+ and enables very effective and long-term monitoring of intracellular free Zn2+ present in the deep tissue. Further provided are a method for preparing the two-photon probe and a method for real-time monitoring of intracellular free zinc... Agent: Christie, Parker & Hale, LLP

20090286273 - Use of neuregulin-beta as an indicator and/or target: The invention furthermore relates to the use of neuregulins, preferably a neuregulin isoform having an isoelectric point in the range from pH 4.3 to 5.0, as a target for detecting and/or exerting an influence on neuronal processes, in particular for exerting an influence on long-term memory. Neuregulins, in particular neuregulin-β... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090286279 - Genetically programmed expression of selectively sulfated proteins in eubacteria: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods... Agent: Quine Intellectual Property Law Group, P.C.

20090286281 - Glycosylation variants of bace: Human BACE polypeptides having modifications to the N-linked glycosylation sites including one or more of the following amino acid substitutions: S174I, N223A, N153Q and N354S. DNA sequences, vectors, and host cells for producing the polypeptides. Crystalline protein compositions formed from the purified polypeptides. Methods of screening for compounds that inhibit... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090286280 - Method for achieving improved polypeptide expression: The present invention relates to methods of optimization of a protein coding sequences for expression in a given host cell. The methods apply genetic algorithms to optimise single codon fitness and/or codon pair fitness sequences coding for a predetermined amino acid sequence. In the algorithm generation of new sequence variants... Agent: Nixon & Vanderhye, PC

20090286282 - Method for producing antibody fragments: An expression library comprising a repertoire of nucleic acid sequences each encoding at least part of a variable domain of a heavy chain derived from an immunoglobulin naturally devoid of light chains and its use in producing antibodies, particularly fragments thereof, is disclosed. The invention provides a method for preparing... Agent: Morgan Lewis & Bockius LLP

20090286283 - Method and affinity column for purifying proteins: Disclosed herein is a method of purifying target proteins from a sample using the specific affinity between a peptide tag and a protease inhibitor. Also disclosed herein is an affinity chromatography medium for purifying proteins in which a support has immobilized thereon a protease inhibitor, and an affinity chromatography column... Agent: Cantor Colburn, LLP

20090286284 - Method of purifying cytidine diphosphate choline: A method of purifying cytidine diphosphate choline, which comprises contacting a cytidine diphosphate choline solution containing a nucleic acid analogue and having a pH of not less than 0.5 and not more than 5.0 with an H-type strongly acidic cation exchange resin, and eluting cytidine diphosphate choline adsorbed onto the... Agent: Leydig Voit & Mayer, Ltd

20090286286 - Methods for controlling amplification: Methods of amplifying nucleic acid on a solid support are described. Beads and template, each in known concentrations, are employed so a range of template to bead ratios can be exploited. Where the beads contain primers, the template can be amplified. After amplification, non-covalently bound template is removed, so as... Agent: Peter G. Carroll Medlen & Carroll, LLP

20090286285 - Modified nucleic acid polymers and methods for their production: The invention is directed to nucleic acid sequences having decreased thermodynamic stability to complementary sequence as well as a method for producing these sequences.... Agent: Cheryl H Agris Phd

20090286287 - Methods and compositions for use in preparring sirnas: Methods and compositions for producing siRNAs, e.g., in the form of a d-siRNA composition, from dsRNAs are provided. In the subject methods, a dsRNA is contacted with a composition that includes an activity that cleaves dsRNA into siRNAs, where the composition efficiently cleaves dsRNA into siRNAs. siRNAs produced by the... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090286288 - Alpha-1, 4-galactosyltransferase (cgtd) from campylobacter jejuni: α-1,4-galactosyltransferase (CgtD) polypeptides, nucleic acids that encode the polypeptides, including a polypeptide from Campylobacter jejuni strain LIO87 have been isolated and characterized A method of producing a galactosylated saccharide comprising contacting an acceptor saccharide containing a terminal galactose, a donor substrate comprising a galactose moiety and one of the CgtD... Agent: Nada Jain, P.C.

20090286289 - Production of hyaluronate unsaturated disaccharides and its application: The present invention includes cell based systems and methods for production of hyaluronate unsaturated disaccharide. The methods and systems include the use of a host cell that produces hyaluronic acid transformed with an expression vector encoding a recombinant chondroitinase AC. Expression of chondroitinase AC in the presence of native hyaluronic... Agent: Biotech Beach Law Group , PC

20090286290 - Method for producing an l-amino acid: A microorganism which has an L-amino acid producing ability and has been modified so that succinate dehydrogenase activity and α-ketoglutarate dehydrogenase activity are decreased is cultured in a medium to produce and accumulate an L-amino acid in the medium or cells of the microorganism, and the L-amino acid is collected... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090286291 - Borrelidin-producing polyketide synthase and its use: The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials and Methods including enzyme systems, nucleic acids, vectors and cells are provided for the preparation of... Agent: Dann, Dorfman, Herrell & Skillman

20090286292 - Producing eicosapentaenoic acid (epa) from biodiesel-derived crude glycerol: Pythium, when cultured with crude glycerol as a carbon source, produces useful polyunsaturated fatty acids such as eicosapentaenoic acid (EPA). The crude glycerol is pretreated to remove soaps and methanol. An exemplary Pythium species for use in the production of EPA is Pythium irregulare.... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20090286293 - Ethanol production in non-recombinant hosts: Non-recombinant bacteria that produce ethanol as the primary fermentation product, associated nucleic acids and polypeptides, methods for producing ethanol using the bacteria, and kits are disclosed.... Agent: Edwards Angell Palmer & Dodge LLP

20090286294 - Methods and compositions for improving the production of fuels in microorganisms: The invention relates to compositions, systems, and methods for producing fuels, such as ethanol and hydrogen, and related compounds. More specifically, compositions and methods are provided for making recombinant microorganisms for the production of fuels using genes from the Clostridium phytofermentans ethanol and hydrogen pathways disclosed herein.... Agent: Fish & Richardson PC

20090286295 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent: Fish & Richardson P.C.

20090286296 - Submerged membrane supported bioreactor for conversion of syngas components to liquid products: A submerged membrane supported bioreactor for anaerobic conversion of gas into liquid products including a plurality of membrane modules having a plurality of hollow fibers, each of the plurality of hollow fibers having a gas permeable hollow fiber wall defining a hollow fiber lumen and an outer surface; a membrane... Agent: Cardinal Law Group

20090286297 - Apparatus and method for tip alignment in multiwell plates: Apparatuses and methods of aligning at least one tip of a tip manifold with a plurality of wells of a multiwell plate. The tip manifold includes a plate, at least one tip depending from the plate, a first tip alignment pin depending from the plate, and a second tip alignment... Agent: Edwards Angell Palmer & Dodge LLP

20090286299 - Engineered luciferases: DNA sequencing techniques are important for a variety of research and diagnostic applications. Pyrosequencing is a “sequencing by synthesis” technique that makes use of luciferase. Modified luciferase enzymes and methods of DNA pyrosequencing are provided. Means of preparing and producing mutant luciferases that have enhanced selectivity for ATP or dATP... Agent: Knobbe Martens Olson & Bear LLP

20090286298 - Microfluidic device, system, and method for controlled encapsulation of particles or particle clusters: A microfluidic device for controlled encapsulation of particles of sub-millimetric dimensions, or clusters of such particles, the device comprising: a first duct for delivering a first liquid phase containing particles for encapsulating in suspension; a second duct for conveying a flow of a second liquid phase that is immiscible with... Agent: Alston & Bird LLP

20090286300 - Microfluidic system and method for sorting cell clusters and for the continuous encapsulation thereof following sorting thereof: A microfluidic system and method for sorting cell clusters, and for the continuous and automated encapsulation of the clusters, once sorted, in capsules of sizes suitable for those of these sorted clusters is provided. The microfluidic system comprises a substrate in which a microchannel array comprising a cell sorting unit... Agent: Alston & Bird LLP

20090286301 - Extraction of biomolecular complexes assisted by alternating hydrostatic pressure: Extraction methods that allow a molecular complex (e.g., an organelle) to be extracted from a sample by employing pressure cycling are described.... Agent: Lando & Anastasi, LLP

20090286302 - Desizing and scouring process: The present invention relates to processes for combined desizing and scouring of a sized fabric containing starch or starch derivatives during manufacture of fabric, which process comprises incubating said sized fabric in an aqueous treating solution having a pH in the range between 1 and 7, which aqueous treating solution... Agent: Novozymes North America, Inc.

20090286303 - Process for preparing (2r,3s)-1,2-epoxy-3-(protected) amino-4-substituted butane and intermediates thereof: The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one... Agent: Louis J. Wille Bristol-myers Squibb Company

20090286304 - Enzymatic digestion of tissue: The present invention concerns a compositions and method for isolating a nucleic acid from a cell-containing sample. There is disclosed a method comprising obtaining at least one cell-containing sample, which comprises a cell containing nucleic acid, obtaining at least one catabolic enzyme, obtaining at least one nuclease inhibitor, preparing an... Agent: Life Technologies Corporation C/o Intellevate

20090286305 - Method for non-destructive macromolecule extraction from biological samples on slide: A thin layer of a biological sample, such as a section of frozen or preserved tissue sample, a section of fresh or preserved cells, and a mono layer of prokaryotic and eukaryotic cells, is placed on a flat surface of a solid supporting base. Macromolecules, such as DNA, RNA, and... Agent: Nianxiang Zou

20090286306 - Sample chamber volume reducer: An apparatus includes a chamber insert capable of being received by a sample chamber of a conditioning system. The received chamber insert reduces the volume of the sample chamber and defines a cavity that substantially surrounds a sample holder located in the sample chamber.... Agent: Bose Corporation C/o Donna Griffiths

20090286307 - Automatic treatment system of leftover food treating device: The present invention relates to an automatic treatment system of a leftover food treating device comprising a setting means for receiving an output voltage of a voltage supplying means and setting control signals of the leftover food treating device; a controlling means for receiving input data through the setting means... Agent: Mcdermott Will & Emery LLP

20090286308 - Process for assembling two surfaces or one surface with a molecule of interest: The present invention relates to a process for assembling at least one zone of a first surface with at least one zone of a second surface or with a molecule of interest, comprising a step that consists in placing the said zone of the said first surface in contact with... Agent: Miles & Stockbridge PC

20090286309 - Device for producing a biologically active substance: A device, a method and a system that are used for producing at least one biologically active substance. The device has at least one unit (12) with a main body (14).... Agent: Posz Law Group, PLC

20090286310 - Inoculation loop assembly: A disposable inoculation loop assembly comprising a test tube and a tube stopper adapted to fit into a free end of the test tube. A first end of the stopper faces into the interior of the test tube substantially hermetically sealing the interior of the test tube. The assembly further... Agent: Paul D. Bianco Fleit Gibbons Gutman Bongini & Bianco Pl

20090286311 - Dna sequences for the expression of alloproteins: The present invention discloses an expression method for non-naturally-occurring amino acid-containing protein comprising: expressing in animal cells: (A) a mutant tyrosyl-tRNA synthetase that is a mutation of tyrosyl-tRNA synthetase originating in E. coli with an enhanced specificity for a non-naturally-occurring tyrosine derivative as compared with the specificity for tyrosine; (B)... Agent: Ostrolenk Faber Gerb & Soffen

20090286312 - Methods and compositions for treating allergic diseases: Disclosed in the present invention are antibodies that specifically recognize and antagonize human TSLP receptor, and methods of employing these antibodies to treat or ameliorate diseases or disorder mediated by TSLP signaling.... Agent: Novartis Institutes For Biomedical Research, Inc.

20090286313 - Non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties: The present invention provides methods and compositions for drug screens to identify and characterize agents that are agonistic or antagonistic to activation of the promoter region of the NAG-1 gene. Activation of the NAG-1 gene is associated with the apoptotic elimination of cancer cells both in vitro and in vivo.... Agent: Leydig, Voit & Mayer, Ltd.

20090286314 - Fluorescent proteins and genes encoding them: are disclosed. Such proteins are e.g. isolated or recombinant fluorescent proteins from a Cephalochordata, such as Branchiostoma floridae or Branchiostoma lanceolatum, or isolated mutants or recombinant proteins that have at least 80% amino acid sequence identity with the fluorescent proteins. Isolated and purified structural genes encoding such fluorescent proteins are... Agent: Bacon & Thomas, PLLC

20090286315 - Process for preserving insulin-secreting cells intended to be transplanted in a patient: Process for preserving insulin secreting cells intended to be transplanted, including the following steps: introducing an initial volume of culture medium and insulin-secreting cells into a culture container, providing a culture medium source, and replacing, at time intervals below 8 hours, the culture medium in the culture container with culture... Agent: Bachman & Lapointe, P.C.

20090286316 - Nucleic acid and corresponding protein entitled 158p3d2 useful in treatment and detection of cancer: A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene... Agent: Agensys C/o Morrison & Foerster LLP

20090286317 - Modular culture system for maintenance, differentiation and proliferation of cells: The invention provides a culture system, which combines a device for undifferentiated proliferation of the cells with a device for cell differentiation and proliferation. Aspects of the invention include a modular culture system, a kit and an associated method for combining undifferentiated proliferation of cells with differentiation and proliferation of... Agent: Foley And Lardner LLP Suite 500

20090286318 - Modules for membrane aeration: The present invention relates to a device for the aeration of liquid media by means of tube aeration, special tube modules contained therein and the use of a device for the aeration of liquid media.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090286319 - Microinjection method and device: An object of the present invention is to provide a method for introducing a physiologically active substance such as a gene into a cell, which introduces a physiologically active substance such as any given gene into any given cell in a view under a microscope, while significantly reducing invasiveness to... Agent: Scully Scott Murphy & Presser, PC

20090286320 - Site-specific recombination in eukaryotes and constructs useful therefor: Site-specific recombinases provide a means of efficiently manipulating chromosomal sequences in mammalian cells in culture and in mice. Embryonic stem cells containing recombinase nucleic acid constructs that were expressed in the male germline would simplify current protocols for producing mice bearing homologously recombined alleles that have been secondarily rearranged by... Agent: Foley & Lardner LLP

20090286321 - Methods for targeting modified raav vectors to mammalian cells: Disclosed are improved VP2-modified recombinant adeno-associated viral (rAAV) vectors, expression systems, and rAAV virions that are fully virulent, yet lack functional VP2 protein expression. Also disclosed are pharmaceutical compositions, virus particles, host cells, and pharmaceutical formulations that comprise these modified vectors useful in the expression of therapeutic proteins, polypeptides, peptides,... Agent: Haynes And Boone, LLPIPSection

  
11/12/2009 > 78 patent applications in 42 patent subcategories. recently filed with US Patent Office

20090280469 - Cell mass capable of serving as a primitive organ-like structure comprised of a plurality of cell types of somatic origin: The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures... Agent: Foley And Lardner LLP Suite 500

20090280470 - Extraction and diagnostic fluid devices, systems and methods of use: The present invention provides devices, systems and methods for RNA isolation from biological samples containing white blood cells, such as whole blood. The devices have a device body that includes a first chamber having a first membrane that selectively binds white blood cells, a second chamber having a second membrane... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20090280473 - Inhibition of membrane fusion proteins: Methods of inhibiting viral infection of a eukaryotic cell by a target virus having a class II virus fusion protein are provided. Also provided are methods of screening a test compound for the ability to inhibit infection by a virus having a class II viral fusion protein. Additionally provided herewith... Agent: Amster, Rothstein & Ebenstein LLP

20090280474 - Method for detecting a virus: This invention is related a method for increasing the sensitivity of detecting a viral target in a sample. The sensitivity may be increased by disrupting a complex comprising the target or by measuring the level of the target from a larger volume of the sample.... Agent: Paul D. Yasger Abbott Laboratories

20090280472 - Method for detection of antigens: The field of the invention relates generally to the detection of antigens, including, but not limited to, quantum dots (Qdots) and metal oxide nanoparticles. More specifically, the invention relates to the detection of antigens on a surface or in a source, which antigens include bacteria, viruses, and small proteins. In... Agent: Fish & Richardson P.C.

20090280471 - Methods for rapid identification of pathogens in humans and animals: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or... Agent: Casimir Jones, S.c.

20090280495 - Activating mutations of platelet derived growth factor receptor alpha (pdgfra) as diagnostic markers and therapeutic targets: This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules... Agent: Klarquist Sparkman, LLP

20090280480 - Devices from prion-like proteins: The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected with such polynucleotides; novel fibrils with specific functionalities and unusually high chemical and thermal stability; and methods of making and using the foregoing in, for example,... Agent: Marshall, Gerstein & Borun LLP

20090280492 - Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a... Agent: Wilson, Sonsini, Goodrich & Rosati

20090280476 - Droplet-based affinity assay device and system: The present invention relates to a droplet-based affinity assay device and system. According to one embodiment, a droplet microactuator is provided and includes an antibody immobilized on a surface. According to another embodiment, a droplet microactuator is provided and includes a droplet on the droplet microactuator, the droplet comprising an... Agent: Ward And Smith, P.A.

20090280475 - Droplet-based pyrosequencing: The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting sequencing protocols, such as the... Agent: Ward And Smith, P.A.

20090280481 - Enhanced sequencing by hybridization using pools of probes: The invention provides methods for sequencing by hybridization (SBH) using pools of probes that allow greater efficiency in conducting SBH by reducing the number of separate measurements of hybridization signals required to identify each particular nucleotide in a target nucleic acid sequence. The invention also provides pools and sets of... Agent: Marshall, Gerstein & Borun LLP

20090280490 - Expression profile algorithm and test for cancer prognosis: The present invention provides a noninvasive, quantitative test for prognosis determination in cancer patients. The test relies on measurements of the tumor levels of certain messenger RNAs (mRNAs). These mRNA levels are inserted into a polynomial formula (algorithm) that yields a numerical recurrence score, which indicates recurrence risk.... Agent: Genomic Health, Inc. C/o Kathleen Determann

20090280478 - Gene methylation and expression: The invention provides a method of analyzing the methylation status of all or part of an entire genome. Moreover, the invention features methods of and reagents for characterizing biological cells containing DNA that is susceptible to methylation. Such methods include methods of diagnosing cancer, e.g., breast cancer.... Agent: Fish & Richardson P.C.

20090280489 - Ig genes specific oligonucleotides and uses thereof: The present invention provides oligonucleotides for detection of rearrangement of immunoglobulin genes for identifying clonality of cells, cancer cells, hypermutation in immunoglobulin gene, antibody isotype producing cell and/or assaying B cell repertoire in a sample. The oligonucleotides disclosed in the present invention are very specific to the immunoglobulin genes.... Agent: Schwegman, Lundberg & Woessner, P.A.

20090280494 - Method for the detection of cytosine methylations in immobilized dna samples: A method is described for the analysis of cytosine methylation patterns in genomic DNA samples. In the first method step, the genomic DNA is isolated from cells or other accompanying materials and bound essentially irreversibly to a surface. Then the DNA bound to the surface is treated, preferably with a... Agent: Kriegsman & Kriegsman

20090280493 - Methods and compositions for the prediction of response to trastuzumab containing chemotherapy regimen in malignant neoplasia: The invention relates to methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of neoplastic disease. Neoplastic disease is often caused by chromosomal rearrangements which lead to over- or underexpression of the rearranged genes. The invention discloses genes which are overexpressed in neoplastic tissue and are useful as... Agent: Siemens Corporation Intellectual Property Department

20090280485 - Methods and reagents for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population: The invention relates to methods and reagents for the determination of telomere length in tissue sections by the single cell telomeric mapping technique based on a fluorescent in situ hybridization step using a telomere-specific probe and an interpolation step using a standard curve correlating fluorescent intensity and telomere length obtained... Agent: Moore & Van Allen PLLC

20090280484 - Methods for gene mapping and haplotyping: The present invention is directed to methods for providing a definitive haplotype of a subject. The haplotype information generated by the methods described herein is more accurate than that provided by prior art methods that only give an inferred haplotype. Accordingly, in one aspect the present invention provides a method... Agent: Birch Stewart Kolasch & Birch

20090280487 - Methods for producing olfactory gpcrs: The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell... Agent: Arena Pharmaceuticals, Inc. Bozicevic, Field & Francis LLP

20090280483 - Methods for screening interleukin-6 (il-6) signal transduction inhibitors: The present invention provides methods for screening compounds which inhibit activation of a member of the IL-6 signaling pathways, comprising: (a) a positive screening step using a cell capable of being killed by IL-6 stimulation to select compounds which inhibit death of the cell when it is stimulated by IL-6;... Agent: Birch Stewart Kolasch & Birch

20090280497 - Multiplex detection compositions, methods, and kits: The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in... Agent: Life Technologies Corporation C/o Intellevate

20090280496 - Non-invasive method for diagnosing fetal cells and cancer cells: A non-invasive method for determining the developmental age of a fetus or detecting cancer cells in a sample is provided. The method utilizes, for example, a sample of blood from a pregnant female and telomeric nucleic acid probes.... Agent: Kelley Drye & Warren LLP

20090280482 - Novel nucleic acid sequences encoding adenylate kinases, alcohol dehydrogenases, ubiquitin proteases, lipases, adenylate cyclases, and gtpase activators: The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the... Agent: Millennium Pharmaceuticals, Inc.

20090280486 - Oligonucleotides for detecting nucleic acids of pathogen causing sexually transmitted diseases: The present invention relates to oligonucleotides hybridizable with nucleic acids of pathogens causing sexually transmitted diseases, kits comprising them, and processes for amplifying and detecting viral nucleic acids using them. The present oligonucleotides completely overcome problems of false-negative and false-positive products in detection of pathogens causing sexually transmitted diseases using... Agent: Miles & Stockbridge PC

20090280491 - Predicting cancer invasiveness: Provided are methods of determining the likelihood of a human cancer being invasive. Also provided are methods of determining whether a lung adenocarcinoma is a bronchioloalveolar carcinoma (BAC). Additionally provided are methods of deciding a course of treatment for a patient with a cancer.... Agent: Sonnenschein Nath & Rosenthal LLP

20090280488 - Prophylactic/therapeutic agent for neurodegenerative disease: (b) a protein having an amino acid sequence resulting from deletion, substitution, addition or insertion of one or more amino acids in the amino acid sequence of SEQ ID NO: 2, 4, 6 or 8 and having binding activity to an abnormal polyglutamine protein produced in a neurodegenerative disease.... Agent: Arthur G. Schaier Carmody & Torrance LLP

20090280498 - Rapid and efficient capture of dna from sample without using cell lysing reagent: Nucleic acids can be made available for amplification or other treatment after admixture of a sample with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, thereby releasing the nucleic acids from the polymer.... Agent: Philip S. Johnson Johnson & Johnson

20090280477 - Turn over probes and use thereof for nucleic acid detection: The invention provides turnover probes for use in a variety of detection assays, for example, nucleic acid detection assays. In addition, the invention provides assays, for example, nucleic acid detection assays, using such turnover probes.... Agent: Goodwin Procter LLP Patent Administrator

20090280479 - Use of free circulating dna for diagnosis, prognosis, and treatment of cancer funding: A method of detecting circulating DNA in a body fluid. The method comprises identifying a subject suffering from or at risk for developing cancer, obtaining a body fluid sample from the subject, and determining the sequence integrity of circulating DNA in the sample, wherein the circulating DNA is not purified... Agent: Hogan & Hartson L.L.P.

20090280501 - A method and a kit for diagnosing type 2 diabetes, metabolic syndrome, sub clinical atherosclerosis, myocardial infarct, stroke or clinical manifestations of diabetes: A method and a kit for diagnosing or prognosing susceptibility to develop type 2 diabetes, the metabolic syndrome, sub clinical atherosclerosis, myocardial infarct, stroke or clinical manifestations of diabetes in a subject. The method comprises detecting and quantifying the amount of bound protein (s), (apoCIII, apoCI, apoA1 or apoE) on... Agent: Pepper Hamilton LLP

20090280502 - Anti-2-o-desulfated acharan sulfate antibody and its application: An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The antibody that reacts with 2-O-desulfated acharan sulfate can be produced by immunizing a mammal using as an antigen a substance... Agent: Knobbe Martens Olson & Bear LLP

20090280500 - Assay for generation of a lipid profile using fluorescence measurement: The present invention relates to a method of generating a lipid profile for a sample solution. The method comprising: a first step of determining the concentration of total lipoprotein in a first aliquot of the sample using fluorescence analysis; a second step of determining the concentration of total cholesterol in... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20090280499 - Method and kit for detecting, or determining 3,4- methylenedioxymethamphetamine: The invention provides a hapten, an immunogen comprising the hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with MDMA.... Agent: Blank Rome LLP

20090280503 - Method for detecting and treating skin disorders: The invention provides for methods of detecting and treating diseased tissue, particularly in skin diseases or disorders, such as psoriasis, scleroderma, eczema or atopic dermatitis tissue. The method involves administrating a composition comprising an antibody specific to the diseased tissue to a patient. After administration, the antibody in the composition... Agent: Klauber & Jackson

20090280505 - Method for detecting lysosomal storage diseases: A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood can be employed as a specimen. The assay... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090280504 - Ns1-np diagnostics of influenza virus infection: The present application describes methods for assessing influenza infection, including prognosis. An assay that determines the amount of the NS1 and NP proteins of influenza virus shows enhanced sensitivity and reliability compared to either antigen alone. Many formats employ pan-specific antibodies (i.e., that react with all or at least with... Agent: Townsend And Townsend And Crew, LLP

20090280506 - Sf, a novel family of taste receptors: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.... Agent: Townsend And Townsend And Crew, LLP

20090280510 - Antibodies specific to heterodimers of bcl-2 family and uses thereof: Isolated antibodies specifically binding to heterodimers of the Bcl-2 family and uses thereof for detecting presence of Bcl-2 heterodimers in a patient.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090280508 - Methods and reagents for preparing and using immunological agents specific for p-glycoprotein: This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090280509 - Surface acoustic wave immunosensor for diagnosing allergy disease and method for diagnosing allergy disease using the same: A surface acoustic wave (SAW) immunosensor for diagnosing allergy disease includes one or more SAW devices on each of which allergens derived from one allergy-causing substance are fixed and an allergen derived from another allergy-causing substance is not included, that is, allergens derived from different allergy-causing substances being fixed on... Agent: Sughrue Mion, PLLC

20090280511 - Methods for selecting candidate peptides presented on the surface of cancer cells following their binding to mhc class i molecules: An objective of the present invention is to provide methods for selecting candidate peptides presented on the surface of cancer cells following binding to MHC class I molecules, wherein the peptides are involved in the stimulation of T cell immunity (cellular immunity). The present inventors discovered a new principle of... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090280512 - Tumor marker for renal cancer and method for determination of occurrence of renal cancer: The present invention provides a tumor marker more highly specific to renal cancer. The present invention provides a method for identifying the morbidity of renal cancer. A tumor marker for renal cancer comprising proteins identified from renal cancerous tissue. A method for identifying the morbidity of renal cancer by using... Agent: Cheng Law Group, PLLC

20090280507 - Method for measurement of sars virus nucleocapsid protein, reagent kit for the measurement, test device, monoclonal antibody directed against sars virus nucleocapsid protein, and hybridoma capable of producing the monoclonal antibody: The present invention provides a method for measuring SARS virus nucleocapsid protein (SARS-NP) using first and second antibodies both binding specifically to SARS-NP, wherein the first or second antibody is an antibody recognizing an epitope located in a region (Region C) of amino acid 283 to 422 from the N-terminus... Agent: Sughrue Mion, PLLC

20090280513 - Compositions and methods for detection, prevention, and treatment of anthrax and other infectious diseases: Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods of immunizing humans or animals against Bacillus anthracis or other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40... Agent: Nixon Peabody, LLP

20090280515 - Compositions and methods for the modulation of pgrmc1: The present invention provides for novel assays and the use of such assays for screening compounds that affect PGRMC1's and related homologue's ability to catalyze the incorporation of cholesterol into membranes. The present invention also provides for methods and compositions for affecting incorporation of cholesterol into membranes. The invention also... Agent: Foley & Lardner LLP

20090280514 - Method for measurement of cholesterol in high-density lipoprotein: The present invention provides a method, a reagent and a kit for the simple and accurate measurement of HDL cholesterol. The method for the measurement of cholesterol in high-density lipoprotein in a sample comprises reacting the sample with i) cholesterol esterase and cholesterol oxidase or ii) cholesterol esterase, oxidized coenzyme... Agent: Fitzpatrick Cella Harper & Scinto

20090280516 - Crystal structure of aldehyde dehydrogenase and methods of use thereof: The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090280519 - Biomarkers for assessing liver function: A method for assessing liver function in an individual, which method comprises determining the level of methylarginine(s) (such as ADMA and/or SDMA) and the ratio of ischemia modified albumin (IMA):albumin ratio (IMAR) in the individual, thereby to assess liver function in the individual.... Agent: Foley And Lardner LLP Suite 500

20090280520 - Fluorescent semiconductor particles, method of manufacturing the same, biosubstance fluorescent labeling agent employing the same, and bioimaging method thereof: Disclosed is a fluorescent semiconductor particle having a core/shell structure composed of a core particle as a semiconductor particle, and a shell layer by which the core particle is covered, wherein the core particle has a different chemical composition from that of the shell layer; the core particle has an... Agent: Lucas & Mercanti, LLP

20090280522 - Method for rapid detection and evaluation of cultured cell growth: Provided is a method and system for the rapid and accurate detection of growth and metabolism of a cellular microorganism in a population of microorganisms in a non-liquid, culture medium. Further provided is a gelled culture medium containing a non-toxic, water-soluble, phosphorescent compound which measures oxygen content (partial pressure) of... Agent: Montgomery, Mccracken, Walker & Rhoads, LLP

20090280521 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics: The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.... Agent: Mccarter & English, LLP Boston

20090280517 - Methods of diagnosis and prognosis for a muscular dystrophy: The invention relates to the treatment, diagnosis, and prognosis of a muscular dystrophy or myopathy. The present inventors have found that the quantity of mu-crystallin is increased in a muscular dystrophy. In particular, the inventors have found that mu-crystallin is increased in facioscapulohumeral muscular dystrophy (FSHD). Based on the inventors'... Agent: Morgan Lewis & Bockius LLP

20090280518 - System for high throughput measurement of mechanical properties of cells: A system for measuring a mechanical property of a cell is provided. The system includes a body having a channel therethrough with a first end and a second end, the channel including at least one cell deforming feature configured to deform a cell passing through the channel. A first sensor... Agent: Wolf Greenfield & Sacks, P.C.

20090280523 - Method for determining the molecular composition of a target tissue or another body structure, and its diagnostic applications: The present invention relates to a sampling instrument adapted for taking a sample in situ and in vivo or taking a sample ex vivo of a target tissue or body structure, in a maximum quantity of less than 10−6 g, said instrument comprising an elongated active member (10) with a... Agent: Oliff & Berridge, PLC

20090280524 - Solid culture medium for the detection and/or the species discrimination of glycopeptide-resistant enterococci: The present invention relates to a solid culture medium for the detection and/or discrimination, among glycopeptide-resistant enterococci, of the groups of species E. faecalis and/or E. faecium belonging to the groups of resistance to the VanA/VanB glycopeptides, and E. gallinarum/E. casseliflavus belonging to the group of resistance to the VanC... Agent: Birch Stewart Kolasch & Birch

20090280525 - Process for the enantioselective reduction and oxidation, respectively, of steroids: e

20090280526 - Method for in vitro molecular evolution of protein function:

20090280527 - Amylase variants:

20090280529 - High throughput transfection of filamentous fungi: The present invention provides a method for the transfection of filamentous fungal cells, comprising providing a multitude of containers, filling into each container an amount of polymer needed for the transfection, filling the cells to be transfected as well as an aqueous solution of transfection reagent into each of the... Agent: Nixon & Vanderhye, PC

20090280528 - Method for cloning and expression of nrui restriction endonuclease: Recombinant DNA encoding NruI- and SboI-like restriction endonucleases and methylases and their amino acid sequences are provided as well as methods for expressing the enzymes in transformed host cells and purifying the enzymes.... Agent: Harriet M. Strimpel, D. Phil.

20090280530 - Novel collagen-like protein clac, precursor thereof and genes encoding the same: A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific to these proteins; and methods of diagnosing treating and preventing Alzheimer's disease by using the same.... Agent: Studebaker & Brackett PC

20090280531 - Preparation of soluble capsid proteins of picornaviruses using sumo fusion technology: A method of producing a soluble capsid protein of a picornavirus using a novel and efficient SUMO fusion protein expression system.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090280532 - Serum-free mammalian cell culture medium, and uses thereof: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or... Agent: Life Technologies Corporation C/o Intellevate

20090280533 - Serum-free mammalian cell culture medium, and uses thereof: The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or... Agent: Life Technologies Corporation C/o Intellevate

20090280534 - Recombinant production of serum albumin: The present invention relates to modified nucleotide sequences encoding serum albumin, wherein the mRNA sequence has been codon optimized for expression in a filamentous host cell. Furthermore the present invention relates to serum albumin produced in filamentous fungi or loaded by contacting serum albumin with an extract of a filamentous... Agent: Novozymes North America, Inc.

20090280535 - Sumo fusion protein expression system for producing native proteins: A simple and efficient SUMO fusion protein expression system for producing native proteins.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090280536 - Expression system for proteins: The invention provides a novel system for the tunable expression of nucleic acids encoding e.g., polypeptides such as recombinant proteins in prokaryotic systems. The system is based on the ability of T7 lysozyme (T7Lys) to inhibit the activity of T7RNAP. Expression of T7Lys can be continuously adjusted as its expression... Agent: Drinker Biddle & Reath (dc)

20090280540 - Directed enrichment of genomic dna for high-throughput sequencing: The present invention provides microarrays of oligonucleotide primer pairs, and in particular, microarrays of primers that comprise at least one cleavable linkage. Also provided are methods to capture oligonucleotide primer pairs from one or more microarrays, and methods to use the captured oligonucleotide primer pairs, such as for amplification of... Agent: Life Technologies Corporation C/o Intellevate

20090280539 - Dna polymerases and related methods: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects by an intercalating dye. Therefore, the mutant polymerases are useful in a variety of disclosed... Agent: Townsend And Townsend And Crew, LLP

20090280537 - Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations: The present invention provides methods, compositions and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or mutations generally occur in the dihydropyrimidine dehydrogenase (DPD) gene in chromosome 1. Also provided are mutant forms of DPD.... Agent: Townsend And Townsend And Crew, LLP

20090280538 - Methods and compositions for nucleic acid sample preparation: Provided are methods and compositions for the production of linear single-stranded nucleic acids, which can be used as templates in high-throughput sequencing systems. Also provided are methods and compositions for the production of closed single-stranded nucleic acid loops, which can be used as templates in high-throughput sequencing systems.... Agent: Quine Intellectual Property Law Group, P.C.

20090280541 - Beta-xylosidase for conversion of plant cell wall carbohydrates to simple sugars: Xylose-containing plant material may be hydrolyzed to xylose using a β-D-xylosidase which exhibits unexpectedly high activity. The enzyme has a kcat value for catalysis of approximately 185 sec−1 for 1,4-β-D-xylobiose (X2) when measured at a pH of 5.3 and a temperature of 25° C.; this is at least 10-fold greater... Agent: Usda-ars-office Of Technology Transfer National Ctr For Agricultural Utilization Research

20090280542 - Method of production of l-amino acids: An isolated polynucleotide encodes a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, with the L-aspartic acid at position 5 of the amino acid sequence replaced by another proteinogenic amino acid, and possesses citrate synthase activity. In addition, a vector comprises the polynucleotide and a bacterium comprises... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090280543 - Regioselective glycosylation: We describe a screening method for the identification of glycosyltransferase polypeptides that regioselectively modify aglycones and the use of said glycosyltransferase polypeptides to modify aglycones.... Agent: Speckman Law Group PLLC

20090280544 - Method for producing optically active 2-benzyloxycyclohexylamine: The present invention relates to a method for the enantioselective acylation of trans-2-benzyloxycyclohexylamine or cis-2-benzyloxycyclohexylamine, according to which an enantiomer mixture of 2-benzyloxycyclohexylamine is reacted with an acylation agent in the presence of a hydrolase. The invention also relates to a method for producing optically active trans-stereoisomers of 2-benzyloxycyclohexylamine.... Agent: Connolly Bove Lodge & Hutz, LLP

20090280545 - Molecule production by photosynthetic organisms: The present invention provides compositions and methods for producing products by photosynthetic organisms. The photosynthetic organisms are genetically modified to effect production, secretion, or both, of products. The methods and compositions are particularly useful in the petrochemical industry.... Agent: Quine Intellectual Property Law Group, P.C.

20090280546 - Yeast strain for production of four carbon alcohols: Yeast cells with a reduced general control response to amino acid starvation were found to have increased tolerance to butanol in the growth medium. The reduced response was engineered by genetic modification of a gene involved in the response, a GCN gene, to eliminate activity of the encoded protein. Yeast... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090280547 - Cellooligosaccharide-fermentative zymobacter transformed microorganisms: This invention provides transformed microorganisms which can produce ethanol from cellooligosaccharide, by introducing β-glucosidase gene by recombinant DNA method, into microorganisms belonging to genus Zymobacter which cannot utilize cellooligosaccharide.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090280548 - Method and device for producing hydrogen: In a step of contacting an organic material including formic acid ions and a carbon source other than the formic acid ions with a microorganism having a formate dehydrogenase gene and a hydrogenase gene under an anaerobic condition, concentration of the formic acid ions in the organic material is set... Agent: Nixon & Vanderhye, PC

20090280549 - Method for treating body fluid: The invention provides a body fluid treatment method for selective ex vivo killing of malignant lymphoma cells, leukemia cells or activated macrophages in a body fluid, the body fluid treatment method comprising: an addition step wherein a compound represented by formula (I) below is added to a body fluid containing... Agent: Drinker Biddle & Reath (dc)

20090280550 - Polymer-factor ix moiety conjugates: Conjugates of a Factor IX moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the... Agent: Nektar Therapeutics

20090280551 - A reagent formulation using ruthenium hexamine as a mediator for electrochemical test strips: Described herein are various embodiments of a test strip, which may be capable of measuring an analyte. The test strip may include a working electrode and a reference electrode where the reagent formulation is disposed on the working electrode. The reagent formulation may be coated onto the test strip. The... Agent: Philip S. Johnson Johnson & Johnson

20090280552 - Methods and compositions for cancer therapy using a novel adenovirus: The invention comprises a novel virus that can kill mammalian cancer cells efficiently. The virus produces a novel protein that converts two non-toxic prodrugs into potent chemotherapeutic agents. These chemotherapeutic agents are produced locally and help the virus kill the cancer cells as well as sensitize them to radiation. In... Agent: Rader, Fishman & Grauer PLLC

20090280553 - Method for designing mutated enzyme, method for preparing the same, and mutated enzyme: It is intended to provide a novel method for improving an enzyme hydrolyzing an a-1,6-glycosidic linkage. A mutated enzyme is designed by specifying one or more amino acids selected from the group shown below in an amino acid sequence of an enzyme (an enzyme to be mutated) that hydrolyzes an... Agent: Edwards Angell Palmer & Dodge LLP

20090280554 - Modified vitamin k-dependent polypeptides: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.... Agent: Fish & Richardson P.C.

20090280555 - Enzyme treatment of foodstuffs for celiac sprue: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.... Agent: Bozicevic, Field & Francis LLP

20090280556 - Mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers and methods and kits for targeting the antigen: This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin, recombinant cells expressing it, methods for targeting... Agent: Townsend And Townsend And Crew, LLP

20090280557 - Method, a device, and an additive for digesting organic matter: A method of producing biogas by anaerobic digestion of organic matter may include adding cobalt, iron, and hydrochloric acid to an organic matter; bringing the organic matter in contact with biogas-producing bacteria; and digesting the organic matter under anaerobic conditions in a reactor while producing biogas and a digested sludge.... Agent: Harness, Dickey & Pierce, P.L.C

20090280558 - Process for dynamic kinetic resolution (dkr) of racemic compounds in (hydro) fluorocarbon solvents: A process for preparing a third compound stereo-selectively which process comprises reacting a substrate comprising a first enantiomeric compound with a racemisation catalyst to give a second enantiomeric compound, and concurrently reacting the second enantiomeric compound in the presence of a biological catalyst to give the third compound, wherein the... Agent: Cook Alex Ltd

20090280559 - Genetic sequencer incorporating fluorescence microscopy: A fluorescence microscopy sequencer comprises a fluid transport subsystem in which reagents are pumped through a series of multi-port valves to a mixer or one or more flow cells, or directly into the flow cell(s). The one or more multi-port valves can be mounted upon a fluids manifold having syringe... Agent: Vedder Price P.C.

20090280560 - Yeast cell surface display of proteins and uses thereof: The present invention provides a genetic method for tethering polypeptides to the yeast cell wall in a form accessible for binding to macromolecules. Combining this method with fluorescence-activated cell sorting provides a means of selecting proteins with increased or decreased affinity for another molecule, altered specificity, or conditional binding. Also... Agent: Greenlee Winner And Sullivan P C

20090280561 - Fusion protein of hiv regulatory/accessory proteins: The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins... Agent: Law Office Of Salvatore Arrigo

20090280562 - Materials and methods for preparing dimeric growth factors: Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a... Agent: Townsend And Townsend And Crew LLP

20090280563 - Method for production of antigen-specific hybridoma using artificial lymph node with good efficiency: o

20090280564 - Method for inducing differentiation of mesodermal stem cells, es cells, or immortalized mesodermal stem cells into neural cells: In addition, according to the present invention, mesodermal stem cells can be differentiated into neural cells by immortalizing the mesodermal stem cells by highly expressing or activating an immortalization gene in the mesodermal stem cells and culturing the cells under an appropriate condition. The methods of the present invention are... Agent: Foley And Lardner LLP Suite 500

20090280565 - High-rate perfusion bioreactor: The present invention relates to a novel perfusion bioreactor allowing continuous medium feed and extraction of metabolites or other desired products from cells. The invention is useful for plant cell cultures but may also be used for mammalian cell cultures, insect cell cultures and bacterial cell cultures. The design of... Agent: Choate, Hall & Stewart LLP

20090280566 - Methods for increasing germination frequency and/or vigor by cold shock treatment of conifer somatic embryos during development: In one aspect, a method is provided for increasing germination vigor and/or frequency of conifer somatic embryos produced in vitro. The method comprises (a) incubating a plurality of immature conifer somatic embryos for a first incubation period in, or on, a first development media at a temperature in the range... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20090280567 - Stabilized sirnas as transfection controls and silencing reagents: RNA molecules, including siRNA molecules and related control, trackability and exaequo agents with specific stability modifications are provided. These molecules are particularly advantageous as transfection control reagents. The molecules include first and second 5′ terminal sense nucleotides with 2′-O-alkyl groups and a label on the first 5′ terminal sense nucleotide,... Agent: Merchant & Gould PC

20090280568 - S100b mini-promoters: Isolated polynucleotides comprising an S100B promoter are provided, where an S100B regulatory element is operably joined to an S100B basal promoter utilizing a non-native spacing between the promoter and regulatory elements. The promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest,... Agent: Bozicevic, Field & Francis LLP

20090280569 - Chloramphenicol resistance selection in bacillus licheniformis: The present invention relates to a modified Bacillus licheniformis host cell, wherein one or more naturally occurring chromosomal chloramphenicol acetyl transferase encoding gene(s), cat, has been inactivated. The inactivation of the chromosomal cat gene(s) allows the use of chloramphenicol as an efficient selective agent in methods for DNA introduction into... Agent: Novozymes North America, Inc.

  
11/05/2009 > 78 patent applications in 42 patent subcategories. recently filed with US Patent Office

20090275011 - Sessile stem cells: Sterile, virally safe, heterologous, homologous, isologous or autologous tissue, tissue-typed or not tissue-typed, which contains predifferentiated and/or differentiable sessile stem cells and which can be used for wound closure and/or promotion of wound healing.... Agent: Baker Botts L.L.P.

20090275012 - Process for determining s-nitrosothiols in biological fluids: A process for determining S-nitrosothiols, in particular S-nitrosoglutathione, in biological fluids that is easy, selective, cheap with respect to the prior art, which requires the use of equipment commonly available in laboratories, at low cost, which can be used by not qualified operators. The process is based on the hydrolysis... Agent: Abelman, Frayne & Schwab

20090275016 - Arrayed detector system for measurement of influenza immune response: A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip... Agent: Nixon Peabody LLP - Patent Group

20090275013 - Method for preparing a monoclonal antibody to the common epitope of nonstructural nss protein of watermelon silver mottle virus and assay for detection of serological related species in the genus tospovirus with the monoclonal antibody: The invention is an assay for detection of Watermelon silver mottle virus (WSMoV)-serogroup tospoviruses using a monoclonal antibody and a method for preparing the monoclonal antibody. A hybridoma cell line that produces a monoclonal antibody against the NSs proteins of WSMoV-serogroup tospoviruses was produced. The hybridoma cell line produces a... Agent: Frenkel & Associates, P.C.

20090275015 - Non-invasive respiratory rapid diagnosis method: A non-invasive method for rapidly determining the specific presence or absence of respiratory pathogens and chemical entities.... Agent: David Allen Hall

20090275014 - Thermal cycling method: This invention provides a method for carrying out nucleic acid amplification reactions involving heating and cooling of samples in sample vessels utilizing a heat block comprising a liquid. The method can be used to perform multiple nucleic acid amplification reactions simultaneously in which each of the reactions is performed so... Agent: Wilson, Sonsini, Goodrich & Rosati

20090275031 - Biomolecular nano device: Methods for measuring environmental parameters using chemical recording are provided. In some embodiments, the methods include generating a polymer comprising an ordered series of chemical units, wherein the position and number of each chemical unit in the polymer is indicative of a reading of the environmental state variable at a... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20090275030 - Cell calcification suppressing proteins, and genes of the proteins: This invention provides cell-calcification inhibitory proteins as well as genes encoding the proteins. Based on the discovery of a novel isoform gene of the c-erg gene (herein referred to as “C-11 gene”) which is an erg gene derived from chickens, the nucleotide sequence of the gene has been determined, and... Agent: Morgan Lewis & Bockius LLP

20090275023 - Compositions and methods for detecting borrelia afzelii: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Borrelia afzelii, a spirochete which is a causative agent of Lyme disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the p24 gene for the outer surface protein of... Agent: Medical Diagnostic Laboratories LLC

20090275040 - Detecting bcl-b expression in cancer and uses thereof: Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast cancer, prostate cancer, lung cancer, or gastric cancer.... Agent: Patent Correspondence Arnall Golden Gregory LLP

20090275018 - Detection of hepatotoxic cyanobacteria: The present invention relates to methods and kits for the detection of toxic cyanobacteria, in particular of hepatotoxin-producing cyanobacteria.... Agent: Townsend And Townsend And Crew, LLP

20090275037 - Fluorescent double stranded dna binding dyes: The present invention is directed to a fluorescent dye comprising a benzothiazolium moiety and a pyrimidinium moiety connected by a mono-methine bridge, characterized in that (i) the 2-position of the pyrimidine carries a substituent which starts with a C-atom and (ii) the 5- and 6-positions of the pyrimidine ring are... Agent: Roche Diagnostics Operations Inc.

20090275043 - Genetic variants in the tcf7l2 gene as diagnostic markers for risk of type 2 diabetes mellitus: Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090275025 - Hpv detection and quantification by real-time multiplex application: The present invention relates to amplification primers and detection probes, which are useful for the detection of human papillomaviruses (HPV), and more particularly of HPV, which can be oncogenic for the mucosal epithelia. The amplification and detection systems provided by the present invention are group-targeted systems, namely A5-, A6- A7-,... Agent: Nixon & Vanderhye, PC

20090275027 - Medium scale intergration of molecular logic gates in an automaton: Compositions and methods for optically detecting the presence of a plurality of oligonucleotides in a sample, wherein each oligonucleotide to be detected comprises consecutive nucleotides having a sequence different than the remaining oligonucleotides of the plurality are provided.... Agent: Cooper & Dunham, LLP

20090275038 - Method and apparatus for forensic screening: This invention relates to methods and system for forensic screening. More specifically, this invention relates to various methods to detect or screen for at least one designated genetic sequences in a plurality of biological sample 40 using a template 30 in conjunction with a laboratory management software 24 to automatically... Agent: Butler, Snow, O'mara, Stevens & Cannada PLLC

20090275044 - Method for detecting human papillomavirus mrna: An in vitro method is provided for screening human female subjects to assess their risk of developing cervical carcinoma which comprises screening the subject for expression of mRNA transcripts from the E6 and optionally the L1 gene of human papillomavirus, wherein subjects positive for expression of L1 and/or E6 mRNA... Agent: Wolf Greenfield & Sacks, P.C.

20090275045 - Method for detecting mammary cancer cells: The present invention provides a novel method for detecting mammary cancer cells which uses, as an index, an expression level of a specific gene in human mammary cancer tissue (or cells). The method is characterized by including (1) measuring an expression level of a gene having a specific nucleotide sequence... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090275042 - Method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator: The present invention relates to a method of detecting and/or quantifying expression of a target protein candidate in a cell, and to a method of identifying a target protein of a small molecule modulator.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090275028 - Method of detecting target nucleic acid: The present invention provides a method of detecting a target nucleic acid which includes a step of examining whether a washing step has been normally conducted. In an aspect of the invention, a monitoring nucleic acid probe to monitor the washing level is used. The probe shows a change in... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20090275039 - Methods for detection and quantification of small rna: Disclosed are methods, kits, and components for detecting small RNA molecules, such as microRNA and siRNA, in a sample. The methods utilize primers and reporter molecules comprising non-natural bases. The disclosed kits may include one or more components for performing the disclosed methods.... Agent: Foley & Lardner LLP

20090275024 - Novel centrerosome-associated protein and applications thereof: A method for diagnosing a genetic disease associated with disturbances in mitotic spindle organization or with cell division anomalies or both, which comprises demonstrating a functional alteration of the gene encoding an ASAP protein comprising at least the following steps of: obtaining DNA containing the gene encoding the ASAP protein... Agent: Dickinson Wright PLLC

20090275017 - Novel nucleoside or nucleotide derivative and use thereof: In one embodiment, the nucleoside or nucleotide of the present invention has a fluorescent dye selected from the group consisting of 5-FAM, 6-FAM, 5-TAMRA, 6-TAMRA, DANSYL, 5-HEX, 6-HEX, 5-TET, 6-TET, 5-ROX and 6-ROX or a quencher dye selected from the group consisting of DABCYL, BHQ1 and BHQ2, which is attached... Agent: Birch Stewart Kolasch & Birch

20090275021 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis: Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.... Agent: Fennemore Craig

20090275041 - Nucleic acid and corresponding protein entitled 193p1e1b useful in treatment and detection of cancer: A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The... Agent: Agensys C/o Morrison & Foerster LLP

20090275019 - Pancreatic cancer genes: The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20090275026 - Primer and probe for detection of mycobacterium intracellulare, and method for detection of mycobacterium intracellulare by using the primer and probe: According to the detection method of the present invention, any false-positive result in diagnosis can be eliminated and detection or diagnosis of M. intracellulare can be carried out with higher accuracy, more preciseness, and more specifically compared to a conventional diagnostic method employing a cell culture assay or a PCR... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090275035 - Primers for human mitochondrial hypervariable region and method for detecting human dna by using the primers: The present invention relates to primer pairs for human mitochondrial hypervariable region and a method for detecting human DNA by using the primer pairs.... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20090275032 - Reprogramming a cell by inducing a pluripotent gene through use of an hdac modulator: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises inhibiting the activity of... Agent: Whyte Hirschboeck Dudek S.c. Intellectual Property Department

20090275022 - Stat6 effects on livestock animal growth: The present invention provides for selection of livestock animals, including bovines, whose genotypes based in the STAT6 gene are correlated with phenotypes reflecting desirable carcass and feedlot traits. These phenotypes include back fat (BFAT), calculated yield grade (CALCYG), cutability (CUT), hot carcass weight (HCW), dry matter intake (DMI), days on... Agent: Townsend And Townsend And Crew, LLP

20090275036 - Systems and methods for real time single molecule sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Life Technologies Corporation C/o Intellevate

20090275029 - Systems and methods to quantify and amplify both signaling and probes for cdna chips and gene expression microarrays: The invention provides a series of reagent compositions and methods for making and amplifying novel cDNA based probe sets from RNA samples to improve analysis with gene expression arrays. The methods globally produce probe sets with common universal linkers at one or both ends, called WRAP-Probes, wherein the linkers do... Agent: Fish & Richardson P.C.

20090275034 - Temperature control system: Single molecule technologies generally require sensitive optical detection and the ability to operate at multiple temperatures simultaneously in different parts of the instrument. The system for controlling the temperature of a microfluidic device and methods for controlling the temperature of sequencing reactions includes a chamber for receiving a microfluidic device,... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090275020 - Traceability of cellular cycle anomalies targeting oncology and neurodegeneration: The present invention relates to the field of medicine and biology. It concerns a novel test for screening and for therapeutic follow-up in oncology. More particularly, it relates to diagnostic and/or therapeutic tests in oncology and on neurodegenerative diseases. It is a diagnostic test and a prognostic test for various... Agent: Jackie Jay Schwartz

20090275033 - Uses of bnipxl-beta in premature canities: The invention also concerns methods for screening molecules modulating the expression of a gene coding for BNIPXL-beta and molecules modulating the activity of the BNIPXL-beta polypeptide, in order to identify an agent for use for cosmetic or therapeutic purposes in the field of pigmentation. The invention also encompasses various uses... Agent: Cooper & Dunham, LLP

20090275048 - Anti-acharan sulfate antibody and its application: An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to acharan... Agent: Knobbe Martens Olson & Bear LLP

20090275046 - Complement factor h protein as a biomarker of parkinson's disease: The present invention relates to a Complement Factor H protein as a biomarker for neurodegenerative disease, including Parkinson's disease, and the related diseases. More specifically, the present invention relates to the identification of a Complement Factor H protein, useful for the screening, diagnosis, and differentiation between neurodegenerative diseases.... Agent: Benjamin A. Adler, Phd, Jd

20090275047 - Crystal structure of human soluble adenylate cyclase: The invention provides the crystal structure of the solAC catalytic domain. The structure is set out in Tables 1 to 5. The structure may be used in to model the interaction of ligands such as pharmaceutical compounds with this protein, and to determine the structure of related adenylate cyclase molecules.... Agent: Millen, White, Zelano & Branigan, P.C.

20090275050 - 14273 receptor, a novel g-protein coupled receptor: The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases,... Agent: Millennium Pharmaceuticals, Inc.

20090275049 - Epha4 polypeptide having a novel activity and use thereof: The present invention provides a polynucleotide which consists of a partial sequence of a polynucleotide encoding the amino acid sequence as shown in SEQ ID NO: 2, wherein the former polynucleotide encodes a polypeptide consisting of a partial amino acid sequence of SEQ ID NO: 2 whose N-terminus starts between... Agent: Darby & Darby P.C.

20090275051 - Luminogenic and nonluminogenic multiplex assay: A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.... Agent: Schwegman, Lundberg & Woessner, P.A.

20090275056 - Methods for obtaining antibodies: The invention is directed towards a method of enriching a population of cells in those cells that produce an antibody which recognises an antigen of interest. In particular, an untagged antigen is used in conjunction with a polyclonal antibody to isolate cells recognizing said antigen.... Agent: Klauber & Jackson

20090275055 - Monoclonal antibodies specific to denatured human class i leucocyte antigens: [MEANS FOR SOLVING THE PROBLEMS] It was discovered that injection of denatured recombinant HILA-A*2402 heavy chain proteins to mouse for immunization led to establish HLA class I-specific antibody binding all of denatured HLA-A, B and C. The present invention is a monoclonal antibody specifically binding HLA-A, HLA-B and HLA-C heavy... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20090275057 - Diagnostic markers predictive of outcomes in colorectal cancer treatment and progression and methods of use thereof: Colorectal cancer patients with operable tumors must decide whether to receive adjuvant therapy after surgical resection in order to reduce their chances of recurrence. Current clinical guidelines are crudely based on the stage of the disease, as well as a few other clinicopathologic features. The instant invention integrates data from... Agent: William C. Fuess

20090275058 - Method for specific detection of salmonella spp.: A method for specific detection of the presence of Salmonella spp. in a sample that is suspected to contain Salmonella spp. and which further comprises one or more other microorganism(s).... Agent: Berenbaum Weinshienk PC

20090275052 - Adjustable molecular motor micropower biosensor and its application: A regulable molecular motor micropower biosensor comprises: a rotary motor, an optical energy conversion device, a signal molecular output device, a power resource system, a protective layer, a supporting material, and a bilayer lipid membrane fixing material. The molecular motor micropower biosensor is used for detecting biological macromolecules, viral molecules,... Agent: Knobbe Martens Olson & Bear LLP

20090275053 - Cell-based pcsk9 screening assay: The present invention includes a PCSK9 activity inhibition assay system, kits, compositions and methods. The present invention includes a cell having a first vector capable of expressing a catalytic fragment of PCSK9, a second vector capable of expressing a prodomain of PCSK9 and a V5 protein with a detectable label.... Agent: Chalker Flores, LLP

20090275054 - Pancreatic cancer genes: The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20090275061 - method to measure serum biomarkers for the diagnosis of liver fibrosis: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different liver fibrosis-associated serum biomarkers in a serum sample, which can be used for the diagnosis of liver fibrosis. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization... Agent: Weili Cheng

20090275060 - Determination of serum anti-mullerian hormone as a diagnostic test for spay in companion animals: This invention relates to non-surgical assays that can be used to determine whether an animal that has a non-postpartum anestrous period of three months or greater, such as a dog or a cat, has been spayed. In particular, the present invention relates to devices, kits and methods that allow correlation... Agent: Casimir Jones, S.c.

20090275059 - Marker proteins for diagnosing liver disease and method of diagnosing liver disease using the same: Using the protein chip technology, biological samples such as sera are subjected to proteome analysis. Thus, a protein which is a human fibrinogen α-E chain decomposition product and has a molecular weight of 5,900, a protein which is an apolipoprotein AII decomposition product and has a molecular weight of 7,800,... Agent: Kratz, Quintos & Hanson, LLP

20090275062 - Method of tacrolimus extraction and quantification using aqueous detergents: The present invention relates to a method of extracting tacrolimus in a test blood sample to use in a tacrolimus quantification assay. The method of the present invention extracts tacrolimus in non-precipitating, non-denaturing aqueous environment, avoiding cumbersome manual pretreatment procedures or the use of organic solvents. The method of the... Agent: Paul D. Yasger Abbott Laboratories

20090275063 - Distinguishing cells in a sample by inactivating extracellular enzyme before releasing intracellular enzyme: A method for detecting the absence or presence of cells of interest in a liquid sample, wherein: (a) the sample: (i) comprises an extracellular medium containing an enzyme with a measurable activity; and (ii) is suspected of containing cells of interest that contain an enzyme with said measurable activity; and... Agent: Mueting, Raasch & Gebhardt, P.A.

20090275064 - Methods to identify therapeutic agents: As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cholesterol oxidation or ozonation products that can act as chemotactic attractants of macrophages, can promote differentiation of monocytes into macrophages and can increase expression of E-selectin and Class A scavenger receptor (SR-A). The present... Agent: The Scripps Research Institute

20090275066 - Immobilization of membrane porteins onto supports via an amphiphile: The invention pertains to the field of membrane protein immobilization onto supports. It relates to a product comprising a support and at least one membrane protein attached to the surface thereof, characterized in that said membrane protein is attached to said support using an amphiphilic molecule with which said membrane... Agent: Pepper Hamilton LLP

20090275065 - Methods and compounds for detecting beta-lactamase activity: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective... Agent: Foley & Lardner LLP

20090275067 - Method of acquiring hepatic oval cells: Provided are a method of isolating and identifying hepatic oval cells from the liver, and a method of single cell culture of hepatic oval cells. A method of separating and/or acquiring hepatic oval cells from a mammal, comprising a step for examining the expression of CD133, CD45 and Ter119. Particularly,... Agent: Leydig Voit & Mayer, Ltd

20090275068 - Method of determining chymase activity with secretory leukocyte protease inhibitor: It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a... Agent: Philip S. Johnson Johnson & Johnson

20090275070 - Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators: This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as... Agent: Kenyon & Kenyon LLP

20090275073 - Diagnosis device and diagnosis method: A diagnosis device includes: a pretreating portion configured to suspend tissue to obtain a suspension; and an analyzing portion configured to analyze the suspension.... Agent: Kimble Intellectual Property Law, PLLC

20090275071 - Diagnostic composition and article for monitoring intravaginal infections: The present invention provides a non-toxic diagnostic composition for intravaginal monitoring of vaginal infections. The present invention further provides a diagnostic article for intravaginal monitoring of vaginal infections with the article including an absorbent material for absorbing vaginal secretions and a composition suitable for identification of the pH or the... Agent: Winston & Strawn LLP Patent Department

20090275072 - In vitro bio-reactor circuit: Embodiments of the invention provide bio-reactor circuits for in vitro research applications. One embodiment provides a bio-reactor circuit comprising at least one bio-reactor and a pump fluidically coupled to the at-least-one bio-reactor. The bio-reactor comprises a housing having inlet and outlet ports and first and second chambers. The chambers are... Agent: Bell & Associates

20090275069 - Pancreatic cancer genes: The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20090275074 - System and method for performing g protein coupled receptor (gpcr) cell assays using waveguide-grating sensors: The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells... Agent: Corning Incorporated

20090275075 - Methods and systems for ensuring the security of food commodities: Aspects include claims, systems, and methods for testing food commodities, including without limitation bulk food commodity stores to identify the presence of contaminants. Such contaminants tested for may include biological, chemical, or radio nuclear material. Another aspect is marking and/or tracking food commodity stores that have been certified as either... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20090275076 - Cell sample preparation method and apparatus: An apparatus and method for automatic thin-layer cell sample slide preparation without requiring human intervention are disclosed. According to one embodiment, a cell sample is measured to derive a cell sample measurement. An estimation of total cellularity of the cell sample is determined based upon the cell sample measurement. A... Agent: Withrow & Terranova, P.l.l.c.

20090275077 - Methods of obtaining optically active epoxides and vicinal diols from styrene oxides: The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific meso-epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for obtaining... Agent: Fish & Richardson P.C.

20090275078 - Alpha-amylase variants: The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular increased starch affinity relative to the parent alpha-amylase.... Agent: Novozymes North America, Inc.

20090275081 - Biotin-ligase system for secretion of biotinylated protein: The present invention provides methods of metabolically biotinylating recombinant proteins. Cell lines and specific protein and nucleic acid constructs for use in the methods of the present invention are also provided herein.... Agent: Townsend And Townsend And Crew, LLP

20090275080 - Glucoamylase variants with altered properties: The present disclosure relates to variants of a parent glucoamylase having altered properties (e.g., improved thermostability and/or specific activity). In particular, the present disclosure provides compositions comprising the variant glucoamylases, including starch hydrolyzing compositions and cleaning compositions. The disclosure also relates to DNA constructs encoding the variants and methods of... Agent: Danisco US Inc. Attention: Legal Department

20090275082 - Mast cell-derived membrane proteins: An originally developed efficient signal sequence trapping method was used to screen a cDNA library prepared from cultured mast cells derived from mouse bone marrow. As a result, genes encoding type I membrane proteins and comprising a single immunoglobulin domain in the extracellular domain and a motif for transmitting an... Agent: Fish & Richardson PC

20090275079 - Novel genes encoding novel proteolytic enzymes: The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein and fragments thereof. The invention also relates to methods of using these... Agent: Nixon & Vanderhye, PC

20090275083 - Isolated peptides having phospholipase inhibitory activity: The invention provides for isolated peptides having phospholipase inhibitory activity, polypeptides comprising phospholipase inhibitory activity and lipases capable of being inhibited by the isolated peptides and/or polypeptides comprising phospholipase inhibitory activity. The invention also relates to nucleic acid constructs, recombinant expression vectors, and recombinant host cells comprising the polynucleotides as... Agent: Novozymes North America, Inc.

20090275084 - Long-acting epo polypeptides and derivatives thereof and methods thereof: A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to an EPO peptide are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.... Agent: Pearl Cohen Zedek Latzer, LLP

20090275085 - enzyme for obtaining prebiotic oligosaccharides: An industrially viable process of obtaining prebiotic oligosaccharides using a new Xanthophyllomyces dendrorhous enzyme, characterized by showing α-glucosidase activity is provided. A process of obtaining an enzymatic product with α-glucosidase activity as well as the substantially pure enzyme with α-glucosidase activity, are also provided. The enzymatic product and the enzyme... Agent: Berenbaum Weinshienk PC

20090275086 - Assembly of large nucleic acids: A method to assemble any desired nucleic acid molecule by combining cassettes in vitro to form assemblies which are further combined in vivo, or by assembling large numbers of DNA fragments by recombination in a yeast culture to obtain desired DNA molecules of substantial size is described.... Agent: Morrison & Foerster LLP

20090275087 - Asymmetric adapter library construction: The present invention provides methods and compositions for asymmetrically tagging a nucleic acid fragment using asymmetric adapters.... Agent: Bozicevic, Field & Francis LLP

20090275088 - Processes for the preparation of highly pure plasmid compositions: The present disclosure generally relates to processes for preparing highly pure plasmid compositions. The processes generally involve treating a composition comprising plasmid DNA with a polypeptide to digest colanic acid. The treated plasmid DNA is then separated from the treated composition.... Agent: Bryan Cave LLP

20090275089 - Mutant phosphoribosylpyrophosphate synthetase and method for producing l-histidine: The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by use of the PRPP synthetase which is resistant... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090275090 - L-amino acid-producing bacterium and a method for producing l-amino acids: A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the β-glucoside PTS activity, and collecting the L-amino acid from the... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090275091 - L-amino acid-producing bacterium and a method for producing l-amino acids: A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the mannose PTS activity, accumulating the L-amino acid in the medium... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090275092 - Method for producing 4-hydroxy-l-isoleucine: A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.... Agent: Cermak Kenealy Vaidya & Nakajima LLP Acs LLC

20090275093 - Biochemical synthesis of 1,4-butanediamine: The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein the increased ODC activity is obtained by means of overexpression of an... Agent: Nixon & Vanderhye, PC

20090275094 - Process for producing sulfur-containing hydroxycarboxylic acid: wherein R1 is the same as defined above, to the action of microbial cells of a microorganism belonging to the genus Pseudomonas, Rhodococcus or Bacillus capable of converting the ketol into a corresponding α-hydroxycarboxylic acid compound, or a treated material thereof, thereby producing the sulfur-containing α-hydroxycarboxylic acid without using a... Agent: Sughrue Mion, PLLC

20090275095 - Dna encoding a protein having a d-lactate dehydrogenase activity and uses thereof: This invention provides a polynucleotide that encodes a protein having lactate dehydrogenase activity and such protein that can be used for producing D-lactic acid. This polynucleotide has the nucleotide sequence as shown in SEQ ID NO: 1 (a), and it hybridizes under stringent conditions with a probe comprising all or... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090275096 - Microorganisms for the production of methacrylic acid: The invention provides a non-naturally occurring microbial organism having a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric... Agent: Mcdermott, Will & Emery

20090275097 - Primary alcohol producing organisms: The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.... Agent: Mcdermott, Will & Emery

20090275098 - Systems and processes for enhanced yield from fermentations that contain xylose: A system and process for the utilization of xylose during fermentation is described. The system uses a fermenter and a separate reactor to isomerize the xylose to xylulose. The separation of the two processes allows the optimization of each process since the isomerization operates ideally in a calcium free environment... Agent: White-welker & Welker, LLC

20090275100 - Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis: The present invention relates to nucleic acid inhibitors, compositions and method for enhancing synthesis of nucleic acid molecules. In a preferred aspect, the invention relates to inhibition or control of nucleic acid synthesis, sequencing or amplification. Specifically, the present invention discloses nucleic acids having affinity for polypeptides with polymerase activity... Agent: Life Technologies Corporation C/o Intellevate

20090275099 - Methods and compositions for treating diseases and conditions associated with mitochondrial function: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, mitochondrial F1F0 ATP hydrolase... Agent: Casimir Jones, S.c.

20090275101 - Pancreatic cancer genes: The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20090275102 - Ehrlichia disulfide bond formation proteins and uses thereof: Novel genes encoding homologous immunoreactive thio-disulfide oxidoreductases, or disulfide bond formation (Dsb) proteins from Ehrlichia chaffeensis and Ehrlichia canis are disclosed. While the E. chaffeensis and E. canis Dsb proteins are at most only 31% or less homologous to other known Dsb proteins, the Ehrlichia Dsbs contain a cysteine active... Agent: Fulbright & Jaworski, LLP

20090275103 - Recombinant hexose oxidase: v

20090275104 - Bacillus licheniformis chromosone: The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods... Agent: Novozymes, Inc.

20090275105 - Process for the production of bromelain by means of substances that induce proteins in pineapple plants: Provided are methods of producing, via induction, plant products such as bromelain from plants of the genus Ananas established in vitro. A process for extracting bromelain from tissues of the pineapple (Ananas comosus) plant that have been established and induced in vitro is provided. The plants have a higher proteolytic... Agent: Feldmangale, P.A.

20090275106 - Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells: A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparanase expression.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090275107 - Scalable production method for aav: A method for producing AAV, without requiring cell lysis, is described. The method involves harvesting AAV from the supernatant. For AAV having capsids with a heparin binding site, the method involves modifying the AAV capsids and/or the culture conditions to ablate the binding between the AAV heparin binding site and... Agent: Howson & Howson LLP

20090275108 - bacillus pumilus strain for high yield of tetramethylpyrazine: This invention provides a high-yield bacterial strain for producing tetramethylpyrazine named Bacillus pumilus RX3-17. The strain has been deposited in China Center for Type Culture Collection on Apr. 19, 2006. The deposit number is CCTCC M 206043. The bacterial strain, isolated from soil, is rod-shaped, 1.5 μm to 3.0 μm... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090275109 - Bacillus strains useful for animal odor control: A composition is provided that includes Bacillus subtilis 2084 (NRRL B-50013) or a strain having all of the identifying characteristics of the Bacillus subtilis 2084 (NRRL B-50013), B. subtilis 27 (NRRL B-50105) or a strain having all of the identifying characteristics of the B. subtilis 27 (NRRL B-50105), and B.... Agent: Whyte Hirschboeck Dudek S.c. Intellectual Property Department

20090275110 - Microorganism that displays biotin on cell surface: Provided is a microorganism that can display, on the cell surface, any molecules other than a molecule comprising amino acids, more specifically, a microorganism that displays biotin on a cell surface. The microorganism is capable of co-expressing a biotinylating enzyme and an acceptor peptide having a sequence recognized by the... Agent: The Webb Law Firm, P.C.

20090275111 - Anaerobically compostable polymeric compositions, articles and landfill biodegradation: Compostable hydrocarbon polymers, composites, and articles anaerobically biodegrade in landfills in a relatively short time. Composite polymeric articles and sheets such as indoor or outdoor signs, billboards, banners, images, protective barriers, backdrops and wall coverings have very useful service durations and yet are landfill biodegradable.... Agent: Wood, Herron & Evans, LLP

20090275112 - Nutrient additives for start-up and sustained operation of a biological filter apparatus: A biological filter apparatus for biological degradation of contaminants in an air stream is operated by passing the air stream through a filter chamber containing a structure supporting a population of microbes and collecting water that drains from the structure and spraying the collected water onto the structure, whereby the... Agent: Smith-hill And Bedell, P.C.

20090275113 - Thermal cycling apparatus: This invention provides an apparatus for providing heating and cooling of samples in sample vessels having uniform temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity. The system employs a heat block containing a liquid composition to efficiently transfer... Agent: Wilson, Sonsini, Goodrich & Rosati

20090275114 - Vibratory mixer: To simplify mixing systems without stirrer systems and to minimize cleaning and validation operations, it is proposed that a vibratory mixer with a vibratory mechanism should have a container. Into this container is inserted a bag which, after use, need not be cleaned and is instead replaced by a new... Agent: George Pappas Harrison Place

20090275115 - Microreactor: Chemical and biological reactors, including microreactors, are provided. Exemplary reactors include a plurality of reactors operable in parallel, where each reactor has a small volume and, together, the reactors produce a large volume of product. Reaction systems can include mixing chambers, heating/dispersion units, reaction chambers, and separation units. Components of... Agent: Wolf Greenfield & Sacks, P.C.

20090275118 - Bacteria detecting instrument, bacteria detecting method, and bacteria detecting kit: A micro array instrument is used in which an oligonucleotide based on a species- or genus-specific nucleotide sequence of subject bacteria is immobilized on a surface of a substrate. By confirming whether the oligonucleotide immobilized on the substrate has hybridized with a probe prepared from a test sample, bacteria contained... Agent: Drinker Biddle & Reath (dc)

20090275116 - Metallic pcr frames: This invention along with certain methods of manufacture significantly contributes to the deterministic consistency of PCR results and the overall cycle time. The ability to achieve a significant reduction in costs is realized from the purchase of reusable PCR frames as well as the savings obtained from the costs associated... Agent: Venugopal Subramanyam

20090275117 - Slip cover for heated platen assembly: A heated platen assembly for use in a biological testing device is disclosed having a heated platen defining a plurality of optical openings configured to permit radiation to pass through the heated platen, a light transmissive slip cover configured to cover at least one of the plurality of optical openings,... Agent: Life Technologies Corporation C/o Intellevate

20090275119 - Liquid chromatograph: The present invention relates to a liquid chromatography apparatus X, which is provided with a deaerator 4. The liquid chromatography apparatus X is further provided with a dissolved oxygen density adjusting means for maintaining a density of dissolved oxygen in an eluting solution to be supplied to a column 60... Agent: Rader Fishman & Grauer PLLC

20090275120 - Extraction of co2 gas from engine exhaust: A photo-bioreactor is used for extraction of carbon dioxide from exhaust gases of an engine used for compression of natural gas by providing a series of vessels and in each contacting the gases with a labyrinthine flow of water containing photo-synthetic organisms. Each vessel receives the gases in series and... Agent: Ade & Company Inc.

20090275121 - Vibrational mixer: A vibrational mixer (1), in particular a single-path mixer for use in single-path bioreactors (4) with flexible walls, consisting of a mixer shaft (2) that can be set into longitudinal motions by a drive (8), with at least one mixing element (3), wherein at least one channel (13) is arranged... Agent: Casella & Hespos

20090275122 - Polypeptides having colanic acid-degrading activity: The present disclosure generally relates to polypeptides having colanic acid-degrading activity and methods of using the same. Polynucleotides encoding such polypeptides are also described. The polypeptides may be used, for example, in processes for degrading colanic acid, processes for the removal of endotoxins from biological samples, and processes for purifying... Agent: Bryan Cave LLP

20090275125 - Human t1r2 taste receptor nucleic acids and cells containing these nucleic acids: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20090275124 - Methods and compositions comprising anti-idiotypic antibodies to anti-mmp-14 antibodies: Provided are anti-idiotypic antibodies specific for a CDR of an anti-MMP-14 antibody for use as reagents in novel assays for anti-MMP-14 antibodies, pharmaceutical compositions and vaccines.... Agent: Lando & Anastasi, LLP

20090275123 - Modified vitamin k-dependent polypeptides: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.... Agent: Fish & Richardson P.C.

20090275126 - Antibodies against insulin-like growth factor i receptor and uses thereof: Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20090275130 - Biomimetic nucleic acids: The present invention is directed to nucleic acids with biomimetic properties and methods for producing said nucleic acids. In particular, this invention relates to nucleic acids exhibiting biomimetic properties in relation to proteins such as growth factors, hormones and/or other cell signaling proteins. Biomimetic properties may generally be defined as... Agent: Bio Tex, Inc.

20090275128 - Medium and culture of embryonic stem cells: Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if high levels of fibroblast growth factor, gamma... Agent: Quarles & Brady LLP

20090275131 - Method for production of mast cells from stem cells: Provided are methods for generating mast cells from pluripotent stem cells in vitro. Methods are disclosed for the differentiation of pluripotent cells, such as iPS cells and/or human embryonic stem cells, into mast cells. The resulting mast cells may be used for various purposes including screening cells for drug development... Agent: Fulbright & Jaworski L.L.P.

20090275129 - Tissue engineered blood vessels: Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.... Agent: Philip S. Johnson Johnson & Johnson

20090275127 - Viable cells from frozen umbilical cord tissue: Viable progenitor cells are extracted from frozen umbilical cord tissue. In embodiments, the umbilical cord tissue is a blood vessel bearing perivascular Wharton's jelly, and the extracted progenitor cells are HUCPVCs.... Agent: Clark & Elbing LLP

20090275132 - Method for purifying cardiomyocytes or programmed cardiomyocytes derived from stem cells or fetuses: The inventors of the present invention found that cardiomyocytes were effectively and highly selected and purified by culturing cardiomyocytes derived from embryonic stem cells in the culture medium under a condition selected from a low-serum-supplemented condition, a low-glucose-supplemented condition, a low-nutritional condition, a low calcium condition, a mildly-acidic pH condition,... Agent: Drinker Biddle & Reath (dc)

20090275133 - Antisense modulation of c-reactive protein expression: Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive... Agent: Jones Day For Isis Pharmaceuticals, Inc.

20090275134 - Compositions of active wnt protein: Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue. Methods for isolation of Wnt utilize detergents that maintain the solubility of the modified protein.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090275135 - Mammalian cytokines; receptors; related reagents and methods: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20090275137 - High affinity tcr proteins and methods: T cell receptors (TCRS) that have higher affinity for a ligand than wild type TCRs are provided. These high affinity TCRs are formed by mutagenizing a T cell receptor protein coding sequence to generate a variegated population of mutants of the T cell receptor protein coding sequence; transforming the T... Agent: Greenlee Winner And Sullivan P C

20090275136 - Nuclear targeting sequence: The present provides nuclear localization signaling (NLS) sequences derived from titin, comprised of amino acids 181-220: SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR and fragments thereof, such as amino acids 193-208: VQGEEEVP AKKTKTIV; amino acids 199-208: VPAKKTKTIV; and amino acids 200-206: PAKKTKT. The NLS sequences can be linked to agents, such as peptides,... Agent: The Webb Law Firm, P.C.

20090275138 - Production of raav in vero cells using particular adenovirus helpers: The present invention relates to methods and materials for recombinant adeno-associated virus production. More particularly, in some embodiments the invention contemplates the use of an adenovirus known as Simian Adenovirus 13 (SAdV-13) and Vero cells for production of recombinant adeno-associated virus (rAAV).... Agent: Marshall, Gerstein & Borun LLP

20090275139 - Materials and methods relating to the production and maintenance of cell lines: The invention provides methods for maintaining cell lines from primary cells, i.e., non-transformed cells, using expression of the signal transducer of activation and transcription (STAT). The methods are particularly suitable for maintenance of B-cells.... Agent: Dann, Dorfman, Herrell & Skillman

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