|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology October categorized by USPTO classification 10/09Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 10/30/2009 > patent applications in patent subcategories.
10/23/2009 > patent applications in patent subcategories.
10/15/2009 > patent applications in patent subcategories.
20090258337 - Thawed organ or tissue or thawed cell group to be donated, transplanted, added, or administered to living body, production process thereof, supercooled solution therefor, and production apparatus of the organ or tissue: The present invention aims to freeze and store organs or tissues taken from human bodies or animals and after thawing, use the resulting organs or tissues, or cells taken and extracted therefrom for medical treatment. The present invention is characterized in that the organs or tissues taken from human bodies... Agent: Hedman & Costigan P.C.
20090258338 - Simulated 5-part differential leukocyte granules, the method for preparing the same and control products and calibrators comprising the same: A method for preparing five-part differential leukocyte analogs from red blood cells includes selecting appropriate red blood cells; treating the red blood cells with a multi-functional reagent system for maintenance of a structural integrity of the membranes of the red blood cells and synchronous adjustment of cell volume, morphology and... Agent: Mindray C/o Stoel Rives LLP
20090258340 - Assay for sars coronavirus by amplification and detection of the replicase sequence: Primers and probes derived from SARS-CoV nucleic acid that facilitate detection and/or quantification of the replicase gene are disclosed. The disclosed sequences may be used in a variety of amplification and non-amplification formats for detection of SARS-CoV infection.... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20090258341 - Compositions and methods for detecting bacteria: Genetically modified bacteriophage and methods of using the same to detect bacterial types of interest are provided.... Agent: Dorsey & Whitney, LLP Intellectual Property Department
20090258342 - Optimized probes and primers and methods of using same for the detection, quantification and grouping of hiv-1: Described herein are optimized primers and probes useful for detecting, quantitating and grouping variant HIV-1 strains, and methods and kits of using the described primers and probes.... Agent: Foley & Lardner LLP
20090258343 - Semi-quantitative immunochromatographic device and method for the determination of hiv/aids immune-status via measurement of soluble cd40 ligand/cd154, a cd4+ t cell equivalent and the simultaneous detection of hiv infection via hiv antibody detection: A semi-quantitative, immunochromatographic dual test device for the simultaneous detection of HIV/AIDS immune status CD4+ T cell equivalents, such as soluble CD40 ligand/CD 154, and the detection of an HIV antibody, includes one or more support materials capable of providing lateral flow. The one or more support materials include at... Agent: Bodner & O'rourke, LLP
20090258339 - Systems, methods and compositions for detection of human papilloma virus in biological samples: The present invention comprises, without limitation, systems, methods, and compositions for the detection, identification, and quantification, down to the single copy level, of human papillomavirus (HPV) in biological samples, including but not limited to, mammalian body fluids and cervix scrapings, for purposes of detection, treatment and/or management of cancer and... Agent: Casimir Jones, S.c.
20090258370 - Acute myelogenous leukemia biomarkers: The present invention provides novel compositions and their use in classifying acute myelogenous leukemia.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090258357 - Cytokine receptor common gamma chain like: The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL... Agent: Kenyon & Kenyon LLP
20090258350 - Diagnostic methods for determining prognosis of non-small cell lung cancer: The invention provides methods for identifying early stage non-small cell lung cancer (NSCLC) patients who will have a favorable prognosis for the recurrence of lung cancer after surgical resection. The invention is based on the discovery that assessment of chromosomal copy number abnormalities at two or more of chromosome 5p15,... Agent: Vysis, Inc Patent Department
20090258348 - Esterases for monitoring protein biosynthesis in vitro: The present invention relates to the use of an esterase for monitoring and/or tracking the synthesis of a protein, polypeptide or peptide in a cell-free translation system or in an in vivo expression system in which the synthesis of a protein, polypeptide or peptide can occur, wherein said monitoring and/or... Agent: Foley And Lardner LLP Suite 500
20090258349 - Method for detecting and quantifying perchlorate-reducing bacteria: The present invention provides methods, compositions, and kits for detecting and quantitating perchlorate-reducing bacteria in samples using reagents that hybridize to and allow amplification of the pcrA gene. The invention includes a quantitative real-time PCR assay for amplification of the pcrA gene which may be used to detect and quantitate... Agent: Townsend And Townsend And Crew, LLP
20090258365 - Method for detecting igf1r/chr 15 in circulating tumor cells using fish: The present invention describes methods and probe composition for an automated FISH assay of a blood sample containing circulating tumor cells expressing the IGF-1R gene. The assay provides genetic analysis of suspect circulating tumor cells that have been identified after immunomagnetic selection and fluorescent labeling. Using unique, repeat-free probes to... Agent: Philip S. Johnson Johnson & Johnson
20090258347 - Method for diagnosing and monitoring cellular reservoirs of disease: The invention provides an assay for diagnosing and/or monitoring a viral infection or disease in a patient, the assay including the steps of mixing a sample of leucocytes with a fluorescent cell membrane-permeable dye which stains RNA or both DNA and RNA within the leucocytes; identifying from all the leucocytes... Agent: Ratnerprestia
20090258360 - Method of detecting equine polysaccharide storage myopathy: The present invention relates to diagnosing Polysaccharide Storage Myopathy (PSSM) disease in equines.... Agent: Viksnins Harris & Padys Pllp
20090258364 - Method of determining the sensitivity of cancer cells to egfr inhibitors including cetuximab, panitumumab and erlotinib: (b) Determining if said cells contain a biomarker that is predictive of a therapeutic response to response to treatment with cetuximab or panitumumab. The biomarker is the mutation status of the PIK3CA gene and the expression status of the PTEN gene. Tumors that harbor activating mutations in Exon 9 and... Agent: Hedman & Costigan P.C.
20090258367 - Method of mapping of mrna distribution with atomic force microscopy: The present invention relates to a method of mapping of mRNA distribution, comprising the steps of a preparing a probe DNA attached to a apical liner region of the dendron on AFM cantilever where the probe DNA can specifically hybridize a target mRNA and measuring specific adhesive force between the... Agent: Jhk Law
20090258346 - Method of selecting sunflower genotypes with high oleic acid content in seed oil: The present invention relates to the selection of sunflower genotypes with high oleic acid content in seed oil. The invention concerns more particularly molecular markers useful for a rapid and easy selection of sunflower lines and then sunflower hybrids capable of producing seeds having high oleic acid content.... Agent: Antonelli, Terry, Stout & Kraus, LLP
20090258351 - Methods and reagents for combined pcr amplification: An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease activity of a polymerase and the... Agent: Life Technologies Corporation C/o Intellevate
20090258358 - Methods for diagnosing and treating kidney and colorectal cancer: Methods, reagents and kits for diagnosing and treating cancer such as kidney or colorectal cancer are disclosed. An immunoassay for detecting kidney or colorectal cancer is based on the relative change of the ADAMTSL4 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney or... Agent: King & Spalding LLP
20090258354 - Methods for dna length and sequence determination: Methods for determining nucleic acid length and sequence variation are provided, for example, between an unknown sample and a reference sample. In various embodiments, a method amplifies one or more specific regions of an oligonucleotide molecule in a sample comprising oligonucleotide molecules to produce a sample of amplicons, the sample... Agent: Bozicevic, Field & Francis LLP
20090258344 - Methods for identifying risk of breast cancer and treatments thereof: Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments... Agent: Grant Anderson LLP C/o Portfolioip
20090258359 - Modular compositing-multiple lot screening protocols for detection of pathogens, microbial contaminants and/or constituents: Provided are methods for sampling, testing and validating test lots, comprising: assembling a plurality of product portions from each of a plurality of test lots and combining the portions to provide a corresponding set of test lot samples; enriching the test lot samples; removing portions of each enriched sample, and... Agent: Davis Wright Tremaine, LLP/seattle
20090258356 - Modulators of the transporter abcd3 for treating acne or hyperseborrhea: An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the peroxisome membrane transporter 1 comprising a type 3 ATP-binding site of the sub-family D (ABCD3), and... Agent: Buchanan, Ingersoll & Rooney PC
20090258355 - Nanoscale clusters and methods of making same: The present invention is a method of making a nanocluster. The method comprises providing a surface comprising at least one anchoring biomolecule, wherein the surface is in a solution; adding an initial recognition-nano-component to the solution wherein the initial recognition-nano-component comprises i) a nanoparticle and one specifically-bindable-biomolecule, or ii) a... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory
20090258369 - Over-expression and mutation of a tyrosine kinase receptor fgfr4 in tumors: This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly FGFR4 variants, which are linked to increased risk of tumor metastasis. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and... Agent: Klarquist Sparkman, LLP
20090258368 - Paramagnetic nucleation nanoparticles: A nucleic acid binding substance which has affinity for nucleic acid polymers. The nucleic acid binding substance is comprised of a nucleic acid binding element capable of specific binding to nucleic acid molecules and connected to a nucleation nanoparticle having paramagnetic properties.... Agent: Hiscock & Barclay, LLP
20090258353 - Pcr primer capable of reducing non-specific amplification and pcr method using the pcr primer: The present invention relates to a PCR primer facilitating hot-start PCR by suppressing non-specific amplification at room temperature and at the same time capable of reducing significantly non-specific amplification by dominating the amplification of the PCR product rather than the amplification of the original template from the third PCR cycle,... Agent: Ballard Spahr Andrews & Ingersoll, LLP
20090258366 - Pcryptornai: A vector developed to transform fungi can be used to study the expression of a gene of interest. The vector can provide for the expression of signal proteins in fungi that can be observed and/or monitored. The vector can be used to investigate the effects of RNA interference on a... Agent: Kilyk & Bowersox, P.l.l.c.
20090258352 - Pin1 as a marker for abnormal cell growth: Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment... Agent: Clark & Elbing LLP
20090258345 - Protein associated with colorectal cancer, polynucleotide including single-nucleotide polymorphism associated with colorectal cancer, microarray and diagnostic kit including the same, and method of diagnosing colorectal cancer using the same: Provided are an isolated nucleolar protein having an amino acid sequence of NCBI GenBank Accession No. XP_033371, a method of diagnosing colorectal cancer in an individual, including measuring an expression level of a protein having an amino acid sequence of NCBI GenBank Accession No. XP_033371 in the individual, and a... Agent: Cantor Colburn, LLP
20090258362 - Rna bioassay: The present invention relates to methods for characterizing the pathological state of the kidney, methods of characterizing an agent, methods of evaluating the kidney protective and therapeutic characteristics of an agent and methods of monitoring the effect of a pharmaceutical agent on the kidney of a subject, related to measuring... Agent: Myers Bigel Sibley & Sajovec
20090258363 - Targeted integration and expression of exogenous nucleic acid sequences: Disclosed herein are methods and compositions for targeted integration of a exogenous sequence into a predetermined target site in a genome for use, for example, in protein expression and gene inactivation.... Agent: Robins & Pasternak
20090258361 - Variant tlr4 nucleic acid and uses thereof: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.... Agent: Schwegman, Lundberg & Woessner, P.A.
20090258372 - Detection systems utilizing supported lipid bilayers: The invention relates to lipid bilayer coated beads and methods of using those beads in immunoassays, in analytical assay and the like.... Agent: Gonzales Patent Services
20090258371 - Method of detecting very low levels of analyte within a thin film fluid sample contained in a thin thickness chamber: A method and apparatus for the detection and quantification of very low levels of a target analyte using an imaging system is provided. In the case of some analytes such as certain hormones, for example TSH, their levels may be as low as several tens of thousands of molecules per... Agent: O''shea Getz P.C.
20090258373 - Methods of controlling the sensitivity and dynamic range of a homogeneous assay: A method is disclosed for accurately determining the concentration of a target analyte utilizes reagent pairs having different affinity for the target. The different affinity provides distinct binding profiles that can be analyzed to absolutely determine the analyte concentration. The method provides an assay system having expanded dynamic range to... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20090258376 - Protein isoforms and uses thereof: (b) comparing the abundance of said Protein Isoform(s) in the test sample with the abundance of said Protein Isoform(s) in a test sample from one or more persons free from neurological disorder, or with a previously determined reference range for that Protein Isoform in subjects free from neurological disorder, wherein... Agent: Klauber & Jackson
20090258375 - Assays for detecting pregnancy-associated glycoproteins: Disclosed are methods and compositions for detecting pregnancy in an animal by means of assaying peptidase activity of one or more Pregnancy Associated Glycoproteins (PAGs). In certain aspects, methods also comprising use of an antibody that binds immunologically to a PAG that displays proteolytic activity are provided. Substrates of proteolytic... Agent: Sonnenschein Nath & Rosenthal LLP
20090258374 - Multisignal labeling reagents, and processes and uses therefor: The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in detecting or amplifying analyte-specific moieties.... Agent: The Webb Law Firm, P.C.
20090258379 - Isolation of membrane vesicles from biological fluids and methods of using same: Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about... Agent: Stites & Harbison, PLLC
20090258377 - Method of measuring enzymatic activity of adsorbed allergenic enzyme: The invention relates to a method of measuring the immunological activity of a vaccine preparation in the form of a mixture of one or more allergenic enzyme(s) and an oxygen-containing metal salt adjuvant, wherein the mixture comprises a liquid phase and a solid phase, and wherein at least a part... Agent: Birch Stewart Kolasch & Birch
20090258378 - Stress-induced phosphoprotein 1 as a biomarker for the detection of human ovarian cancers and endometriosis: Disclosed herein is a method for the detection, preliminary screening or monitoring of a gynecological disease selected form ovarian cancers and endometriosis, in which STIP1 is used as a biomarker for the gynecological disease.... Agent: Christie, Parker & Hale, LLP
20090258380 - Perhydrolase epitopes: The present invention provides perhydrolase enzyme CD4+ T-cell epitopes, as well as variants that exhibit reduced immunogenic responses, as compared to the parental perhydrolase . The present invention further provides DNA molecules that encode perhydrolase variants, and host cells comprising DNA encoding perhydrolase variants, as well as methods for making... Agent: Jill A. Jacobson Genencor International
20090258381 - Methods for determining the cleavability of substrates: The invention relates to methods for examining the enzymatic cleavability of substrates. In the methods, compounds, which have a cleavability of the section to be examined, are firstly synthesized on a first solid phase, separated therefrom, the cleavage reaction is carried out in solution and the cleaved and uncleaved compounds... Agent: Nixon & Vanderhye, PC
20090258382 - Novel devices for the detection of the presence and/or activity of proteases in biological samples: The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090258383 - Opto-fluidic architecture for particle manipulation and sorting: This invention provides an apparatus for particle sorting, particle patterning, and methods of using the same. The sorting or patterning is opto-fluidics based, in that particles are applied to individual chambers in the device, detection and/or analysis of the particles is carried out, such that a cell or population whose... Agent: Pearl Cohen Zedek Latzer, LLP
20090258384 - Direct antimicrobial susceptibility assay: An antimicrobial susceptibility assay, including the steps of: providing an assay dish; providing a growth medium in said dish; providing an antimicrobial agent sample; providing an interpretive indication located a predetermined distance from a sample location adjacent the growth medium in the assay dish; providing an interfitting element which interfits... Agent: Read R. Taintor
20090258385 - Method of analyzing cells by flow cytometry, use of an antioxidant and/or free radical-scavenging agent in such a method and incubation buffer comprising an antioxidant and/or free radical-scavenging agent: The invention relates to a method of analyzing cells by flow cytometry and the use of an antioxidant and/or free radical-scavenging agent in such a method. It also relates to an incubation buffer comprising an antioxidant and/or free radical-scavenging agent. The method of the invention comprises a step for labeling... Agent: Alston & Bird LLP
20090258386 - Methods for solid mutagenesis and semi-solid fluid mutagenesis fermentation and purification of lipid soluble vitamins and nutrients: According to the invention, Applicants have demonstrated methods for improving industrial biosynthesis of lipid soluble vitamins and nutrients. Applicants have also provided methods for cost-efficient and commercially-viable chemotherapeutic biosynthesis and purification. This invention provides novel methods for both solid mutagenesis and semi-solid fluid mutagenesis fermentation and the purification of lipid... Agent: Nyemaster, Goode, West, Hansell & O'brien, P.C.
20090258387 - Bioactive whey protein hydrolysate: The invention relates to a partial hydrolysate of when protein which contains bioactive peptides but does not have a bitter flavour. The hydrolysate is carried out using selective enzymes which produce the active peptides and is terminated at a degree of hydrolysis before substantial bitter flavours are created. There are... Agent: Knobbe Martens Olson & Bear LLP
20090258389 - Construction of new variants of dextransucrase dsr-s by genetic engineering: The present invention relates to a recombinant process for the production of truncated and/or mutated dextransucrases while conserving their enzymatic activity and/or their specificity in the synthesis of the α-1,6 bonds. More precisely, the present invention relates to nucleic acid sequences of truncated and/or mutated dextransucrases, vectors containing said nucleic... Agent: Kusner & Jaffe Highland Place Suite 310
20090258388 - Methods of enhanced heterologous protein secretion: A method of enhancing heterologous protein secretion in a yeast cell is disclosed. In one embodiment, the method comprising the steps of engineering a yeast cell to overexpress at last one gene selected from the group consisting of CCW12, CWP2, SED1, RPP0, ERO1 and their homologs, supplying the yeast cell... Agent: Quarles & Brady LLP
20090258390 - Prokaryotic collagen-like proteins and uses thereof: The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host... Agent: Benjamin Aaron Adler Adler & Associates
20090258391 - Recombinant cell clones having increased stability and methods of making and using same: Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention... Agent: Baxter Healthcare Corporation
20090258394 - Method for the production of high-level soluble human recombinant interferon alpha in e. coli and vectors useful for such a production: A method for the production of high-level soluble human recombinant interferon alpha protein (rhuIFNα) in E. coli and vectors useful for such a production which comprises: (1) transforming an E. coli selected in the group consisting of E. coli protease deficient host strains, and E. coli reductase deficient host strains,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090258392 - Sequence diversity generation in immunoglobulins: Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations... Agent: Seed Intellectual Property Law Group PLLC
20090258393 - Single chain class i major histocompatibility complexes, constructs encoding same and methods of generating same: Provided are methods of generating a functional mammalian single chain MHC class I complex in prokaryotic expression systems and a host cell transformed with expression construct(s) capable of expressing a functional human single chain MHC class I complex capable of presenting specific antigenic peptides restricted to specific CTL clones.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090258395 - Irx-2 modified manufacturing process: A highly efficient method of making a primary cell derived biologic by purifying mononuclear cells (MNCs) in a automated cell processor to remove contaminating cells by loading leukocytes onto lymphocyte separation medium (LSM) and centrifuging the medium to obtain purified MNCs, storing the MNCs overnight in a closed sterile bag... Agent: Kohn & Associates, PLLC
20090258396 - Crustaceans as production systems for therapeutic proteins: A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a gene inserted into the recombinant virus genome, and the virus... Agent: Moore & Van Allen PLLC
20090258397 - Method of producing meningococcal meningitis vaccine for neisseria meningitidis serotypes a, c, y, and w-135: Methods for producing quadrivalent meningococcal meningitis polysaccharide and conjugate vaccines for serotypes A, C, Y and W-135 disclosed. Neisseria meningitidis fastidious medium was designed to maximize the yield of capsular polysaccharides and generate minimal cellular biomass and endotoxin in a short duration of fermentation. The crude polysaccharides are isolated, purified,... Agent: Jeeri R. Reddy
20090258399 - Method for production of amino acid: According to the present invention, there are provided a microorganism belonging to Enterobacteriaceae wherein a function of CsrB RNA or CsrC RNA has been decreased or lost, and which has the ability to produce and accumulate an amino acid, and a process wherein the microorganism is cultured in a medium... Agent: Leydig Voit & Mayer, Ltd
20090258398 - Process for the production of beta-amino acids using acylase: The present invention relates to a Variovorax sp. which produces an acylase having an asymmetric hydrolysis activity on an N-acetyl β-amino acid to selectively produce an R-β-amino acid, and a Burkholderia sp. which produces both an acylase having an asymmetric hydrolysis activity on an N-acetyl β-amino acid to selectively produce... Agent: Cermak & Kenealy LLP Acs LLC
20090258401 - L-amino acid producing bacterium and method of producing l-amino acid: L-amino acid is produced by culturing a bacterium belonging to the Enterobacteriaceae family which has L-amino acid-producing ability and is modified so that expression of the nhaA gene, nhaB gene, nhaR gene, chaA gene, mdfA gene, or combinations thereof is enhanced.... Agent: Cermak & Kenealy LLP Acs LLC
20090258400 - Mutant tyrosine repressor, a gene encoding the same, and a method for producing l-dopa: A mutant tyrosine repressor that does not require tyrosine to induce expression of tyrosine phenol-lyase gene is obtained by introducing a mutation into a tyrosine repressor. A microorganism which is able to express large amounts of tyrosine phenol-lyase is obtained by introducing the mutant tyrosine repressor into the microorganism. The... Agent: Cermak & Kenealy LLP Acs LLC
20090258402 - L-glutamic acid producing bacterium and a method for production of l-glutamic acid: A method for producing L-glutamic acid by culturing a coryneform bacterium which has L-glutamic acid producing ability and which has been modified so that expression of the fasR gene is enhanced in a medium to produce and accumulate L-glutamic acid in the medium or cells, and collecting L-glutamic acid from... Agent: Cermak & Kenealy LLP Acs LLC
20090258403 - Novel aldolase, and method for producing optically active ihog and monatin: The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090258404 - Production of fermentation products in biofilm reactors using microorganisms immobilised on sterilised granular sludge: Production of fermentation products, such as ethanol and lactic acid in biofilm reactors by microorganisms immobilised on sterilised granular sludge.... Agent: Roberts Mlotkowski Safran & Cole, P.C. Intellectual Property Department
20090258405 - Preparation of optically active alcohols with whole-cell catalysts: The present invention relates to a process for the preparation of optically active alcohols from ketones with the aid of whole-cell catalysts comprising an alcohol dehydrogenase and also an enzyme capable of cofactor regeneration, a substrate concentration of at least 500 mM of ketone being provided for the conversion and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.
20090258406 - Use of esterases for separating plastics: The invention relates to agents containing esterases, and to the use thereof for dressing fibres, in particular, artificial fibres, washing and cleaning agents comprising esterases and corresponding washing and cleaning methods, in addition to additional technical areas of application. The invention also relates to the use of esterases for protecting... Agent: Connolly Bove Lodge & Hutz LLP
20090258407 - Temperature transfer devices: A portable temperature transfer device for transferring thermo energy to and/or from a laboratory culture plate is provided as well as its methods of use. The temperature transfer device comprises a base and a raised stage that comprises a thermal conductive material. The raised stage allows direct contact between individual... Agent: Don D. Cha
20090258408 - Method for the isolation of spiroplasma in mammals: The present invention is directed to a method of isolating and culturing spiroplasma by obtaining a tissue sample from a bovine; inoculating embryonated eggs with the tissue sample; mixing fluid from the inoculated egg with culture media; culturing the media mixed with the egg fluid at approximately 32° C. for... Agent: Birch Stewart Kolasch & Birch
20090258410 - Methods for producing soluble membrane spanning proteins: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in... Agent: Morrison & Foerster LLP
20090258409 - Purified sr-p70 protein: The invention relates to new nucleic acid sequences of the family of tumor-suppressing genes related to the gene for the p53 protein, and to corresponding protein sequences.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC
20090258411 - Centrifugal device and method for ova detection: A centrifugal device and method are provided for the separation of buoyant material such as parasitic ova from fecal matter. A rotor assembly, rotatable about its central axis in a centrifuge, includes a housing with a centrally located top opening leading to a centrally located mixing chamber. An annular sediment... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP
20090258412 - Reactor: Disclosed herein is a reactor, including, a plurality of reaction regions, a plurality of heating elements, each arranged in each of the reaction regions, and cooling elements that cool other regions than reaction regions which are heated by the heating elements, wherein the heating element including a heater and a... Agent: Wolf Greenfield & Sacks, P.C.
20090258413 - Reactor: Disclosed herein is a reactor including, a plurality of reaction regions, and a plurality of heaters, each arranged in each of the reaction regions, wherein the heater including a semiconductor heat generating element and a semiconductor temperature detecting element and being capable of independent temperature control, and the temperature detecting... Agent: Wolf Greenfield & Sacks, P.C.
20090258415 - Fluid manipulation assembly: Microfluidic assemblies, systems, and methods are provided for manipulating fluid samples. Assemblies include an elastically deformable cover layer and a less elastically deformable substrate. The methods include deforming the substrate through the cover layer so that when the cover layer rebounds a new communication results in the assembly between the... Agent: Life Technologies Corporation C/o Intellevate
20090258414 - System for fluorescence monitoring: The present invention is directed to devices for performing PCR and monitoring the reaction of a sample comprising a nucleic acid and a fluorescent dye. Illustrative devices comprise a heat exchange component for heating and cooling the sample, a control device for repeatedly operating the heat exchange component to subject... Agent: Ice Miller LLP
20090258416 - Polymer micelle complex including nucleic acid: It is an object of the present invention to provide a polyion complex used as a non-viral gene vector, which achieves sufficiently high gene expression efficiency to a target cell. The polyion complex of the present invention comprises a block copolymer formed by binding polyethylene glycol to polycation via a... Agent: Darby & Darby P.C.
20090258417 - Culture vessel and a method of culture: A culture vessel comprising a gas permeable film which has oxygen permeability of PO2×S/V>2.0, carbon dioxide permeability of PCO2×S/V>8.0 and water vapor permeability of PH2O×S/V<0.02 where V (ml) is a set capacity, S (cm2) is area of the gas permeable film, PO2 (ml/cm2•day•atm) is oxygen permeability at 37° C., PCO2... Agent: Hedman & Costigan P.C.
20090258418 - Reactive 1,3'-crosslinked carbocyanines and their bioconjugates: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.... Agent: Jeffrey A. Mckinney, J.d., Ph.d.
20090258419 - Method for removing prion protein: The present invention relates to a method for removing prion PrPSc proteins from biological material by contacting a biological material comprising prion PrPSc proteins with sepharose under conditions that allow for the specific and high affinity binding of the sepharose to the prion PrPSc proteins and removing the biological material... Agent: The Nath Law Group
20090258420 - Altered polypeptides, immunoconjugates thereof, and methods related thereto: The present invention features inter alia altered binding polypeptides having engineered cysteine residues or analogs thereof at a predetermined site within, for example, a constant region domain or a portion thereof. The engineered cysteine residues or analogs thereof provide sites for conjugating effector moieties (e.g. diagnostic or therapeutic agents) that... Agent: Lahive & Cockfield, LLP / Biogen Idec Floor 30, Suite 3000
20090258421 - Embryonic stem cells and neural progenitor cells derived therefrom: The present invention provides undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, and committed progenitor cells such as neural progenitor cells capable of giving... Agent: Scully Scott Murphy & Presser, PC
20090258422 - Optically detectable organophosphonates: in which X represents an optically detectable moiety, n is an integer with 1≦n≦20, R1 is an unbranched or branched alkyl group having 1 to 20 carbon atoms, and R2 is hydrogen or —CH2—O—R3 group, wherein R3 has the same meaning as R1. These compounds are useful as inhibitors of... Agent: Birch Stewart Kolasch & Birch
20090258423 - Cell cycle regulation and differentiation: The present invention provides compositions and methods for regulating neural cell proliferation or differentiation. The present invention also provides methods for selecting for bioactive agents effective in regulating proliferation or differentiation.... Agent: Wilson, Sonsini, Goodrich & Rosati
20090258424 - Cellular delivery of sirna: The invention provides a method for delivering a nucleic acid to a cell using a targeting molecule that is bound non-covalently to the nucleic acid. Compositions and kits are also provided.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20090258425 - Gene knock-down by intracellular expression of aptamers: Materials and Methods are provided for target validation by gene knock-down with intracellularly expressed aptamers and siRNAs. The aptamers produced by the materials and methods of the invention are useful in target validation for therapeutics development.... Agent: Mintz, Levin, Cohn, Ferris, Glovskyand Popeo, P.C.10/08/2009 > patent applications in patent subcategories.
20090253115 - Composition for preserving platelets and method of using the same: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally,... Agent: Morris Manning Martin LLP
20090253117 - Enzymatic substrates for multiple detection systems: An inventive substrate is provided which includes a substrate compound of formula A-B1-B2-B3-B4: wherein A is a sugar moiety; B1 is a linker moiety allowing the conjugation of moiety A and the remaining structure of the substrate; B2 is a linker moiety with a free reactive amino group so as... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.
20090253118 - Luminescence quenchers and fluorogenic probes for detection of reactive species: Provided herein are compounds or fluorogenic probes which can be used as reagents for measuring, detecting and/or screening ROS or RNS such as peroxynitrite or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of peroxynitrite or hypochlorite in chemical samples and... Agent: Jones Day
20090253116 - Metabolic syndrome evaluating apparatus, method, system, program, and recording medium therefor: According to the method of evaluating metabolic syndrome, amino acid concentration data on the concentration value of amino acid in blood collected from a subject to be evaluated is measured, and the state of metabolic syndrome in the subject is evaluated based on the measured amino acid concentration data of... Agent: Foley And Lardner LLP Suite 500
20090253120 - Dna virus detection by dna chip: The disclosure relates to chips containing nucleic acid probes or primers and their use in methods to detect nucleic acid molecules of DNA viruses. The disclosure includes DNA chips in contact with a thermocycler capable of automatically regulating the temperature, temperature cycle times, and number of temperature cycles of the... Agent: Patentique PLLC
20090253123 - Hepatitis b variants with reduced sensitivity to therapeutic compounds, their detection and uses thereof: The present invention is a diagnostic kit and materials for: 1) the prediction of the long-term response of a chronic hepatitis B virus (HBV) carrier to treatment with nucleoside/nucleotide analogue, or their combination; 2) the detection of HBV variants that exhibit reduced reactivity to antibody detection; 3) the detection of... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090253119 - Lateral flow system and assay: The present invention relates to a lateral flow assay and system, including a test strip, for detection and quantification of analytes in samples, such as samples containing cells and fluid. In general, according to the present invention, a test strip for a lateral flow assay for detection of at least... Agent: Global Patent Group - Rla
20090253121 - Method for amt-rflp dna fingerprinting: An improved method for identifying and classifying organisms is provided. The method comprises the steps of obtaining a sample of DNA, isolating a portion of the sample to be analyzed, cutting the sample portion into at least two fragments, ligating both ends of the fragments with double-stranded linker sequences, adding... Agent: Husch Blackwell Sanders LLP
20090253124 - Method for detecting human papillomavirus mrna: An in vitro method is provided for screening human female subjects to assess their risk of developing cervical carcinoma which comprises screening the subject for expression of mRNA transcripts from the E6 and optionally the L1 gene of human papillomavirus, wherein subjects positive for expression of L1 and/or E6 mRNA... Agent: Wolf Greenfield & Sacks, P.C.
20090253122 - Method for measuring resistance of a patient hiv-2 to protease inhibitors: A search method in a biological sample containing an HIV 2 viral strain for possible resistance of said strain to treatment by an anti-protease agent, and nucleotide probes for the implementation thereof. According to methods known per se, the presence of at least one mutation at certain, specified, particular positions... Agent: Oliff & Berridge, PLC
20090253140 - Assay for genetic polymorphisms using scattered light detectable labels: Described are methods for determining the presence or absence of particular polymorphisms in CYP2D6 and other genes using scattered light detectable particles as detectable labels, and compositions useful in such methods.... Agent: Buchanan, Ingersoll & Rooney PC
20090253130 - Bio memory disc and bio memory disc drive apparatus, and assay method using the same: The present invention provides a bio memory disc where a lab-on-a-chip process system including an assay-diagnosis unit, a nucleic acid hybridization assay unit, or an immuno-assay unit and a semiconductor memory is disposed, a bio memory disc drive apparatus including a controller for controlling and driving an optical disc including... Agent: Staas & Halsey LLP
20090253126 - Biomarker detection assays: A method for identifying compounds capable of modulating the Notch pathway. The test compound is either administered to an animal or is brought into contact with a cell in culture, after which the expression of the basic helix-loop-helix transcription factor Math1 in a sample from said animal or cell is... Agent: Astra Zeneca Pharmaceuticals Lp Global Intellectual Property
20090253134 - Cellular pyrogen test: The invention concerns methods, agents and kits for qualitative and quantitative detection and identification of pathogens and pathogen spectra based on endotoxins and other pyrogens.... Agent: BatemanIPLaw Group
20090253142 - Compositions and methods for analysis of nucleic acid molecules during amplification reactions: The present invention provides systems, methods and kits for performing a detection assay (e.g., invasive cleavage assay) in combination with an amplification assay (e.g., PCR), where the detection assay employs enzyme footprint probes with relatively short (e.g., 6-12 bases) analyte-specific regions configured to provide a preferred footprint length of duplex... Agent: Casimir Jones, S.c.
20090253139 - Compositions and methods for glioma classification: The present invention provides novel compositions and their use in classifying gliomas. In a preferred embodiment, the methods are used to discriminate between oligodendroglioma and glioblastoma.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090253127 - Compositions for marking objects with dna and methods for marking and linking an object to its owner: The invention can be summarized as follows. There is provided one or more DNA coating compositions that comprise one or more polymer compounds, water, and optionally one or more non-water polar solvents. The DNA coating composition may also comprise DNA. Also provided are methods and kits for marking objects with... Agent: Suzannah K. Sundby Smith, Gambrell & Russel, LLP
20090253133 - Enhanced t cell receptor-mediated tumor necrosis factor superfamily and chemokine mrna expression in peripheral blood leukocytes in patients with crohn's disease: A method is disclosed for determining whether a human having Crohn's disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohn's disease therapy in... Agent: Knobbe Martens Olson & Bear LLP
20090253143 - Fluorophore compounds: Provided herein are fluorophore compounds including rhodol and rhodamine compounds which can be used as fluorescent labels and/or fluorogenic probes and methods of making same. Provided also herein are methods that can be used to track, measure, detect, or screen biological species such as protein, DNA, enzyme, antibody, organelle, cell,... Agent: Jones Day
20090253136 - Genetic risk assessment technology for epithelial cancer involving gene-environment interaction between ercc5 and tobacco use: Methods and compositions for assessing ERCC5 gene expression in view of certain environmental exposures and determining the risk of an individual for developing one or more epithelial cancers are provided.... Agent: Banner & Witcoff, Ltd.
20090253131 - Hybrid fusion reporter and uses thereof: The invention provides vectors encoding hybrid fusion proteins and vector sets encoding different hybrid fusion proteins useful, for instance, in protein complementation assays.... Agent: Schwegman, Lundberg & Woessner, P.A.
20090253129 - Identification of usa300 community-associated methicillin-resistant staphylococcus aureus: The present invention provides methods for identifying the US A300 strain of methicillin-resistant Staphylococcus aureus (MRSA).... Agent: Mueting, Raasch & Gebhardt, P.A.
20090253138 - Kif20a directed diagnostics for neoplastic disease: Disclosed are methods for diagnosing cancer in a test cell sample or fluid sample by detecting an increase in the level of expression of KIF20A in the test cell sample or fluid sample as compared to the level of expression of KIF20A in a control cell sample or fluid sample... Agent: Wilmerhale/boston
20090253145 - Method for detecting and quantitating multiple subcellular components: A method for detecting and quantitating multiple and unique fluorescent signals from a cell sample is provided. The method combines immunohistochemistry and a fluorescent-labeled in situ hybridization techniques. The method is useful for identifying specific subcellular components of cells such as chromosomes and proteins.... Agent: Kelley Drye & Warren LLP
20090253141 - Methods and apparatuses for analyzing polynucleotide sequences: Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090253144 - Methods of assessing dna damage: This invention relates to the finding that HP1β is phosphorylated at Thr51 at an early stage in the DNA damage response in cells. Thr51P HP1β is therefore a biomarker for DNA damage which may be useful, for example, in assessing DNA damage, cancer susceptibility or the responsiveness of an individual... Agent: Bozicevic, Field & Francis LLP
20090253137 - Methods of screening for risk of proliferative disease and methods for the treatment of proliferative disease: A method of screening a subject for a proliferative disease risk factor comprises detecting the presence or absence of upregulation of the CLN3 gene in the subject. The upregulation of the CLN3 gene in the subject indicates the subject is at increased risk of developing a proliferative disease. Methods of... Agent: Myers Bigel Sibley & Sajovec
20090253132 - Mutated acvr1 for diagnosis and treatment of fibrodyplasia ossificans progressiva (fop): This invention is directed to mutated Activin A type I receptor proteins (ACVR1) and isolated nucleic acids encoding same. The invention also relates to the use of mutated ACVR1 in the diagnosis and treatment of Fibrodysplasia Ossificans Progressiva (FOP).... Agent: Pearl Cohen Zedek Latzer, LLP
20090253128 - Nucleotide sequence for identifying of acinetobacter bacteria, and method and kit of identification of acinetobacter bacteria: Nucleotide primers for identifying Acinetobacter bacteria. The nucleotide primers of the invention are SEQ ID No: 1 to 13, which can be used to effectively and accurately identify various Acinetobacter bacteria. Additionally, the invention further provides a method and kit of identification of Acinetobacter bacteria using the SEQ ID No:... Agent: Muncy, Geissler, Olds & Lowe, PLLC
20090253135 - Polymorphisms of the blys gene and use in diagnostic methods: The present invention provides an isolated polynucleotide comprising at least one polymorphic nucleotide sequence, for example, the major alleles of the SNPs described as rs12583006, rs1224141, and rs1248930 and diagnostic assays for detecting the presence of these polymorphism associated with a condition associated with BLyS activity, such as hematological malignancy... Agent: Fish & Richardson P.C.
20090253147 - Marker for stem cells: Methods and compositions are provided for the identification of stem cells, including neural, muscle and hair follicle stem cells.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP
20090253146 - Methods of expressing integrin beta6 subunits: The present invention provides substantially pure integrins containing a novel β subunit designated as β6. The novel β6 subunit forms heterodimers with αV and αF. Methods of controlling cell adhesion using the β6-containing integrins are also provided.... Agent: Townsend And Townsend And Crew, LLP
20090253148 - Fluorescence polarization herg assay: Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein... Agent: Life Technologies Corporation C/o Intellevate
20090253153 - Methods of using a g protein-coupled receptor to identify peptide yy (pyy) secretagogues and compounds useful in the treatment of conditions modulated by pyy: The present invention relates to methods of using GPR119 receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY, such as conditions modulated by stimulation of NPY Y2 receptor (Y2R). Agonists of GPR119 receptor are useful as therapeutic agents for treating or... Agent: Fish & Richardson P.C.
20090253152 - Novel mutant igfbp-3 molecules that do not bind to igfs, but retain their ability to functionally bind igfbp-3 receptor: There is disclosed novel mutant IGFBP-3 polypeptides and fragments thereof that have either no binding, or diminished binding to IGFs, yet retain their ability to bind to the human IGFBP-3 receptor (“P4.33”). The present invention provides novel mutant IGFBP-3 nucleic acid sequences, and expression systems. Additional exemplary embodiments provide for... Agent: Davis Wright Tremaine, LLP/seattle
20090253151 - Self-renewing master adult pluripotent stem cells: The present invention relates to a method for obtaining master adult pluripotent stem (MAPS) cells from adult human corneal epithelial tissues. The MAPS cells are obtained on the basis of pluripotent markers. Further the invention provides MAPS cells that are capable of self renewal and differentiation and have characteristics similar... Agent: Oliff & Berridge, PLC
20090253149 - Novel chemistry used in biosensors: The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.... Agent: Morgan, Lewis & Bockius, LLP
20090253150 - Three part assay for kinase or phosphatase activity: The present invention relates to a method of determining kinase or phosphatase activity based on a three parts system. The method comprises contacting a binding partner which can bind phosphorylated peptides, a detection molecule and a substrate peptide. Determination of activities is achieved by measuring energy transfer between an energy... Agent: Hoffmann-la Roche Inc. Patent Law Department
20090253154 - Blood and saliva test for detection of delayed food allergy and intolerance against modified foods: A method for determining the presence of delayed food allergy and intolerance against antigens extracted from modified foods. The method includes determining a level of antibodies against a modified dietary food antigen in blood and mucosal samples from the patient and comparing the level with normal levels of the antibodies.... Agent: Cislo & Thomas LLP
20090253155 - Method for diagnosing irritable bowel syndrome and monitoring inflammatory bowel disease: A method for aiding in differentiating irritable bowel syndrome from inflammatory bowel disease by determining the level of total endogenous human lactoferrin in clinical specimens, such as feces, mucus and bile, wherein an elevated level of lactoferrin substantially precludes diagnoses of IBS and other noninflammatory etiologies, and a kit usable... Agent: Shook, Hardy & Bacon LLP Intellectual Property Department
20090253156 - Mass spectrometry methods for multiplexed quantification of protein kinases and phosphatases: The inventions relates to methods and kits for capture and/or analysis of kinases and/or phosphatases in one or more samples. In some embodiments, a kinase inhibitor, e.g. staurosporine or its derivative, is used to capture kinases from a sample. In some embodiments, a phosphatase inhibitor, e.g. microcystin or its derivative,... Agent: Wilmer, Hale, Perkin & Elmer, LLP
20090253157 - Method of directed differentiation of porcine embryonic stem cells and using the said cells in drug screening: The present invention relates to a method of directed differentiation of porcine embryonic stem cells into specific neural lineages. The present invention also relates to a method for identifying neurogenic stimulator using the said porcine embryonic stem cells.... Agent: Occhiuti Rohlicek & Tsao, LLP
20090253158 - Lipoxygenase enzyme assay: A method for identifying inhibitors of a lipoxygenase enzyme, the assay comprising: contacting a lipoxygenase enzyme with a test Compound, a lipoxygenase enzyme Substrate and oxygen; adding a fluorometric reagent and a peroxidase; measuring the fluorescent signal; determining the amount of enzyme inhibition by the test Compound.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation
20090253161 - Fluorescent prochelators for cellular iron detection: m
20090253159 - Ion channel assay methods: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a... Agent: Knobbe Martens Olson & Bear LLP
20090253162 - Method and apparatus for analyzing skin and hair: The present invention includes compositions, methods, and systems for the analysis of skin and hair conditions. The system includes a method and apparatus for analyzing skin and hair samples by taking a sample, identifying desired components of the sample, obtaining an image electronically, storing the image, and analyzing the image... Agent: Chalker Flores, LLP
20090253160 - Novel method of predicting pig litter size by evaluating semen: e
20090253163 - Iterative staining of biological samples: Automated methods and devices that facilitate iterative staining of biological samples from imaging applications are provided. The methods include the steps of providing a small volume flow cell containing a biological sample, applying a stain to the biological sample, combining at least two precursor reagents to form an activated destaining... Agent: General Electric Company Global Research
20090253164 - E. coli for efficient production of caratenoids: An improved E. coli for carotenoid production comprising exogenous nucleic acids for expressing a carotenoid that the E. coli requires as necessary condition for the E. coli to reproduce. Some E. coli embodiments have diminished or abrogated expression of a gene in the group consisting of ldhA, frdA, poxB, pta,... Agent: Dardi & Associates, PLLC
20090253166 - conjugation of peptides: Methods for the selective conjugation of peptides which comprises an enzymatic incorporation of a functional group at the C-terminal end of a peptide followed by reaction with a second compound comprising the moiety to be conjugated to the peptide, wherein said second compound comprises a functional group which selectively reacts... Agent: Novo Nordisk, Inc. Intellectual Property Department
20090253165 - Method for preparing microcapsules by coacervation: The present invention relates to a method for preparing microcapsules by coacervation, and to the use of transglutaminase for cross-linking in complex coacervation. The present invention relates further to coacervation processes in general in which a material to be encapsulated is added to a solution comprising at least one colloid... Agent: Winston & Strawn LLP Patent Department
20090253176 - Cell lines and methods for producing proteins: The methods of the present invention involve the manipulation and/or propagation of oviduct tumor cells derived from either wild-type or transgenic avians.... Agent: Synageva Biopharma Corp.
20090253174 - Expression of heterologous sequences: The present invention provides compositions and methods for expression of heterologous sequences. The compositions and methods are particularly useful for expressing large quantity of heterologous proteins and nucleic acids of therapeutic, diagnostic and industrial applications.... Agent: Wilson Sonsini Goodrich & Rosati
20090253173 - Filamentous fungi with inactivated protease genes for altered protein production: The invention relates to a filamentous fungal cell (e.g., Aspergillus sp.) comprising at least one inactivated protease gene chosen from apsB, a homolog of apsB, cpsA, a homolog cpsA, and combinations thereof. Nucleic acids and methods for making the inactivated mutant filamentous fungal cells are provided as well as methods... Agent: Steven G. Bacsi Danisco US Inc., Genencor Division
20090253172 - Growth factor homolog zvegf4: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the... Agent: Townsend And Townsend And Crew LLP
20090253177 - Maize cellulose synthases and uses thereof: The invention provides isolated cellulose synthase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering cellulose synthase levels in plants. The invention further provides recombinant expression cassettes, host cells, and transgenic plants comprising said nucleic acids.... Agent: Pioneer Hi-bred International, Inc.
20090253167 - Methanol-responsive promoter, fusion gene comprising promoter and foreign gene connected so that foreign gene can be expressed, vector, transformant, and method of producing protein: A methanol-responsive promoter includes the following regions (1) and (2) in this order in the direction from its 5′- to 3′-terminal (1) a methanol-responsive region that is selected from the group consisting of the following (a), (b) and (c) (a) a polynucleotide consisting of the nucleotide sequence of SEQ ID... Agent: Charles N.j. Ruggiero, Esq. Ohlandt, Greeley, Ruggiero & Perle, L.L.P.
20090253171 - Methods for producing secreted polypeptides having biological activity: The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a... Agent: Novozymes, Inc.
20090253168 - Novel transporter protein: A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912, a novel gene was discovered to encode a protein which is able to transport hydantoin compounds. A recombinant with an excellent ability to... Agent: Cermak & Kenealy LLP Acs LLC
20090253170 - Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same: Novel plant derived regulatory sequences and constructs and methods of using such sequences for directing expression of exogenous polynucleotide sequences in trichomes are provided.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090253178 - Recombinant cell clones having increased stability and methods of making and using the same: Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention... Agent: Baxter Healthcare Corporation
20090253175 - Soluble hyaluronidase glycoprotein (shasegp), process for preparing the same, uses and pharmaceutical compositions comprising thereof: Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active... Agent: K&l Gates LLP
20090253169 - Use of genetically modified organisms to generate biomass degrading enzymes: The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga... Agent: Quine Intellectual Property Law Group, P.C.
20090253179 - Mammalian cell lines for increasing longevity and protein yield from a cell culture: Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene,... Agent: Immunomedics, Inc.
20090253180 - Diagnosis of liver pathology through assessment of anti-gal igg glycosylation: Methods for diagnosing pathology of the liver in subject suspected of having such pathology by measuring the glycosylation of anti-gal IgG in various biological fluids of the subject.... Agent: Woodcock Washburn LLP
20090253182 - Fed-batch fermentation process and culture medium for the production of plasmid dna in e. coli on a manufacturing scale: A process for producing plasmid DNA E. coli cells comprises a pre-culture and fed-batch process. The culture media of the batch phase and the culture medium added during the feeding phase are chemically defined. The culture medium of the feeding phase contains a growth-limiting substrate and is added, for at... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation
20090253181 - Universal sample preparation system and use in an integrated analysis system: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.... Agent: Wilson Sonsini Goodrich & Rosati
20090253183 - Amplicon rescue multiplex polymerase chain reaction for amplification of multiple targets: Disclosed is a method for amplifying and detecting polynucleotides which can provide sensitive, specific detection of multiple targets from a clinical specimen within a relatively short time.... Agent: Donna J. Russell
20090253184 - Compositions and methods related to an adenoviral trans-complementing cell line: Embodiments of the invention include E1 expressing cell lines that can be used in a variety of methods for production of an E1 defective adenovirus. In certain aspects a cell of the invention can be adapted to various culture conditions, e.g., suspension culture in serum free medium. In a further... Agent: Fulbright & Jaworski L.L.P.
20090253185 - Avipox recombinants expressing foot and mouth disease virus genes: The present invention relates to modified poxyiral vectors and to methods of making and using the same. In particular, the invention relates to recombinant avipox that expresses gene products of foot and mouth disease virus (FMDV), and to compositions or vaccines that elicit immune responses directed to FMDV gene products... Agent: Frommer Lawrence & Haug
20090253125 - Denaturat stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof: Novel denaturant-stable, protease resistant, homo-oligomeric proteins, also referred to herein as stable proteins (SPs), having chaperone-like activity; methods of production and purification of SPs; nucleic acids encoding SPs; methods of isolating nucleic acids encoding SPs; antibodies recognizing SPs; the use of SPs for stabilizing, refolding, repairing, preventing aggregation and de-aggregating... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090253186 - Microorganism producing l-methionine precursor and the method of producing l-methionine precursor using the microorganism: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.... Agent: Lucas & Mercanti, LLP
20090253187 - Microorganism producing l-methionine precursor and the method of producing l-methionine precursor using the microorganism: The present invention relates to a microorganism producing L-methionine precursor, O-succinylhomoserine, and a method of producing L-methionine precursor using the microorganism,... Agent: Lucas & Mercanti, LLP
20090253188 - Delta-4 desaturase and its use in making polyunsaturated fatty acids: Described here are Δ4 desaturases that convert all-cis-7,10,13,16,19-docosapentaenoic acid [“DPA”; 22:5 ω-3] to docosahexaenoic acid [“DHA”; 22:6 ω-3], with secondary activity in converting docosatetraenoic acid [“DTA”; 22:4 ω-6] to all-cis-4,7,10,13,16-docosapentaenoic acid [“DPAn-6”; 22:5 ω-6]. Also, described here are isolated nuclei acid fragments and recombinant constructs comprising such fragments encoding Δ4... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090253189 - Lactic acid-producing yeast cells having nonfunctional l- or d-lactate:ferricytochrome c oxidoreductase cells: Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced I, or D-lactate:ferricytochrome c oxidoreductase... Agent: Gary C. Cohn, PLLC
20090253190 - Enhanced metabolite generation: The present invention relates to the enhanced production of metabolites by a process whereby a carbon source is oxidized with a fermentative microbe in a compartment having a portal. An electron acceptor is added to the compartment to assist the microbe in the removal of excess electrons. The electron acceptor... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory
20090253191 - Use of rhizopus amylases in granular starch hydrolysis: Described are compositions and methods relating to granular starch hydrolysis. Exemplary used for the compositions and methods are for ethanol production.... Agent: Danisco US Inc. Attention: Legal Department
20090253192 - Process for the biological production of 1,3-propanediol with high titer: The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanediol is achieved by the use of an E. coli transformed with... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090253193 - Apparatus and method for evaluating ex vivo tissue samples by electrical impedance: A device for characterizing ex vivo tissue employs a set of independent electrodes that may be used to scan the tissue by moving a voltage gradient across the tissue surface acquiring impedance spectrographs that may be mapped to an image.... Agent: Boyle Fredrickson S.c.
20090253194 - Dna analysis apparatus: Accurate and sensitive sequencing in pyrosequencing is achieved by allowing complementary strand synthesis reaction to proceed homogeneously and completely in a short time while performing luminescence reaction for a sufficiently long time. DNA as a sequencing target is immobilized on the surface of a solid supporter. Nucleic acid substrates are... Agent: Mattingly & Malur, P.C.
20090253196 - Fluid handling unit and fluid handling apparatus using same: A fluid handling unit 16 has an inside cylindrical portion 16c which is arranged in an outside small-diameter cylindrical portion 16b so as to be eccentric with respect to the outside small-diameter cylindrical portion 16b, and a plurality of slits 16d for establishing a communication between an inside fluid housing... Agent: Bachman & Lapointe, P.C.
20090253195 - Plate platform with visual indicator: A plate platform having a visual indicator that allows the user to track his or her progress in loading the platform wells is generally disclosed. The plate platform is constructed from a substantially transparent base having a plurality of elongated bore-holes internally from the side surface in the substantially transparent... Agent: Dority & Manning, P.A.
20090253197 - Culture plate comprising a lid for lateral ventilation: The present invention pertains to a culture plate, and in particular to a culture plate comprising a lid wherein the peripheral side wall of the lid is formed at least partially of at least one filter element made of a filter material. This enables lateral, uniform ventilation of the culture... Agent: Knobbe Martens Olson & Bear LLP
20090253198 - Cell culture dish: The present invention relates to a to a cell culture dish and particularly to a Petri dish. In the present cell culture dish the wall portion of the base and the top portion of the cover are both provided with markings enabling the correlation of particular cell growth areas to... Agent: Knobbe Martens Olson & Bear LLP
20090253199 - Card member for receiving a tissue specimen to be processed for histological examination: The present invention is directed to a card member for receiving a tissue specimen to be processed for histological examination including an absorbent portion for maintaining the tissue specimen in engageable contact with the card member, and a generally non-adhesive portion for allowing separation of the tissue specimen from the... Agent: Thompson Coburn LLP
20090253200 - Cadherin-11 antagonists and methods for the treatment of inflammatory joint disorders: The present invention relates to Cadherin-11 antagonists and compositions comprising Cadherin-11 antagonists. The invention also relates to methods for treating inflammatory joint disorders, such as rheumatoid arthritis, in a mammalian subject by administering a therapeutically effective amount of a Cadherin-11 antagonist.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20090253201 - Embryonic stem cells capable of differentiating into desired cell lines: An embryonic stem cell which may be induced to differentiate homogeneously into a desired primary cell line. The embryonic stem cell may be engineered with DNA, which encodes a protein or polypeptide which promotes differentiation of the stem cell into a specific cell line, such as, for example, a neuronal... Agent: Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein
20090253202 - Definitive endoderm: Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.... Agent: Knobbe Martens Olson & Bear LLP
20090253203 - Reprogramming a cell by inducing a pluripotent gene through use of a small molecule modulator: The invention relate to methods, compositions, and kits for reprogramming a cell. In one embodiment, the invention relates to a method comprising inducing the expression of at least one gene that contributes to a cell being pluripotent or multipotent. In yet another embodiment, the method comprises exposing a cell to... Agent: Whyte Hirschboeck Dudek S.c. Intellectual Property Department
20090253204 - Continuous flow chamber device for separation, concentration, and/or purification of cells: The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive... Agent: Blank Rome LLP
20090253205 - Thermophilic and thermoacidophilic sugar transporter genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.... Agent: Traskbritt / Battelle Energy Alliance, LLC
20090253207 - Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells: A gene delivery vehicle having been provided with at least a tissue tropism for cells selected from the group of smooth muscle cells, endothelial cells, and/or liver cells. The tissue tropism is generally provided by a virus capsid, such as one comprising protein fragments from at least two different viruses,... Agent: Traskbritt, P.C.
20090253206 - Nuclear transport agent and method for producing said agent: The present invention relates to a transport agent for transporting nucleic acids into eukaryotic cells and a method for producing said agent. The invention further concerns methods for transporting nucleic acids into eukaryotic cells using the transport agent according to the invention. The present invention provides an alternative transport agent... Agent: Joyce Von Natzmer Pequignot + Myers LLC
20090253208 - Recombinant viral vector for gene transfer into lymphoid cells: A recombinant herpesvirus, a method for producing the recombinant herpesvirus, and a pharmaceutical composition comprising the recombinant herpesvirus, are provided with a method for producing a recombinant herpesvirus using a BAC vector sequence. In addition, a vector comprising a herpesvirus genomic gene and a BAC vector sequence, a cell comprising... Agent: King & Spalding LLP10/01/2009 > patent applications in patent subcategories.
20090246750 - Devices and methods for collection, storage and transportation of biological specimens: The present invention provides methods for collecting, storing or transporting liquid suspension of biological specimens containing analytes of interest in a dry state. The dried biological specimens containing analytes of interest are reconstituted and released for subsequent analysis by compressing or centrifuging the matrix. Also provided are method of using... Agent: Sutherland Asbill & Brennan LLP
20090246752 - Apparatus and method for detecting microscopic living organisms using bacteriophage: A method for detecting one or more target bacteria in a raw sample where: 1) bacteriophage(s) specific to each target bacterium are added to the raw sample, 2) the test sample is incubated, and 3) the test sample is tested for the presence of each phage in sufficient numbers to... Agent: Patton Boggs LLP
20090246753 - Detection of phage amplification by sers nanoparticles: A phage specific antibody presenting particle, devices and methods related to detection of phage amplification are provided.... Agent: Dorsey & Whitney, LLP Intellectual Property Department
20090246751 - Method for the detection of virus infected cells: The present invention relates to a method for determining one or more stressed cell(s) in a medium. The method comprises the steps of (i) providing a sample from the medium, and (ii) determining a change in the sample relative to a normal sample of non-stressed cell(s).... Agent: Foley And Lardner LLP Suite 500
20090246754 - Optimized probes and primers and methods of using same for the detection and quantitation of bk virus: Described herein are probes and primers for detecting and quantitating variant BK viral strains and methods and devices of identifying and using the described probes and primers.... Agent: Intelligent Medical Devices, Inc. C/o Foley & Lardner LLP
20090246777 - Allelic discrimination analysis using an efficiency related value (efr): In various embodiments this invention provides novel methods for discriminating two or more different target nucleic acids. In certain embodiments the methods comprise providing data amplification reactions comprising reagents to amplify two or more different target nucleic acids where the data comprise signals comprising an amplitude measurement representing the degree... Agent: Weaver Austin Villeneuve & Sampson LLP
20090246782 - Barriers for facilitating biological reactions: The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.... Agent: Casimir Jones, S.c.
20090246774 - Chromosomal blocks as markers for traits: The present invention provided a method for predicting a phenotype in a bovine animal, the method comprising analysing a nucleic acid sample from said animal for the presence of at least one genetic marker known to reside in an Linkage Disequilibrium (LD) block in any one of bovine chromosomes BTA-I... Agent: Fish & Richardson P.c.
20090246771 - Compositions and methods comprising biomarkers of sperm quality, semen quality and fertility: Provided are compositions and methods for determining or diagnosing abnormal sperm or fertility, comprising: obtaining sperm DNA from a test subject; determining the methylation status of at least one CpG dinucleotide sequence of at least one gene sequence selected from HRAS, NTF3, MT1A, PAX8, DIRAS3, PLAGL1, SFN, SAT2CHRM1, MEST, RNR1,... Agent: Davis Wright Tremaine, LLP/seattle
20090246767 - Compositions and methods for detecting cryptococcus neoformans: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Cryptococcus neoformans, a causative agent for human cryptococcosis. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the fungal specific transcription factor gene in Cryptococcus neoformans, are useful as forward and reverse... Agent: Medical Diagnostic Laboratories, Llc
20090246793 - Cudr as biomarker for cancer progression and therapeutic response: Disclosed is a novel human gene designated CUDR. Provides is also a CUDR gene as a biomarker in the diagnosis of human cancers and a cancer therapy.... Agent: Knobbe Martens Olson & Bear LLP
20090246761 - Development of prognostic markers from the saliva of head and neck cancer patients: The present invention relates to biomarkers that are useful for the detection of cancer. The invention further relates to biomarkers and methods of using biomarkers for the early detection of head and neck cancer.... Agent: Hogan & Hartson L.l.p.
20090246773 - Diagnostic compositions and treatment methods for conditions involving trophoblast cell death, differentiation, invasion and/or cell fusion and turnover: The invention provides a method for diagnosing in a subject a condition requiring modulation of or involving trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, comprising detecting HIF Iα and the factors which modulate or are modulated by this protein, specifically TGFβ3, sFLT, VEGF, SMAD2, 3 and 7,... Agent: Howson & Howson LLP
20090246763 - Electrochemical labels derived from siderophores: Disclosed are tri-nuclear metal complexes and salts thereof, such as tri-nuclear osmium or ruthenium complexes or salts thereof, suitable for use as electrochemical labels. Also disclosed are oligonucleotide probes with an attached electrochemical label, methods of nucleic acid amplification, methods of sequencing, and kits for nucleic acid amplification and sequencing... Agent: Patent Docket Department Armstrong Teasdale LLP
20090246791 - Engineered fluorescent dye labeled nucleotide analogs for dna sequencing: Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the nucleotide analogs. Kits, methods and systems are provided for analysis of nucleic acid synthesis reactions.... Agent: Pacific Biosciences Of California, Inc.
20090246789 - Gene mutation profiling of csmd1: A method for assessing risk of node-positive colorectal cancer in an individual is described. The method includes detecting mutations in CSMD1 genes in a tumor sample from the individual, the mutations being associated with increased risk of node-positive colorectal cancer.... Agent: Dority & Manning, P.a.
20090246770 - Glycemic control for reduction of cardiovascular disease risk in diabetic patients expressing haptoglobin 2-2: This invention relates to methods of reducing risk of developing cardiovascular complications in diabetic patients. Specifically, the invention relates to the use of haptoglobin genotyping for determining the importance of maintaining tight glycemic control in diabetic subjects expressing Hp 2-2 allele.... Agent: Pearl Cohen Zedek Latzer, LLP
20090246780 - High throughput physical mapping using aflp: The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor compatible primers carrying selective nucleotides at their 3′ end. The... Agent: Foley And Lardner LLP Suite 500
20090246766 - High throughput screening of genetically modified photosynthetic organisms: The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga... Agent: Quine Intellectual Property Law Group, P.c.
20090246778 - Identification of fat and lean phenotypes in chickens using molecular markers: The present invention identifies genetic markers for lean and fat phenotypes in chickens and provides methods of screening chickens to determine those more likely to have a lean or fat phenotype. The invention also provides methods of screening chickens to identify a polymorphism in THRSPα associated with a fat or... Agent: Ratnerprestia
20090246779 - Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-cgh: The present invention relates to a method of diagnosing a premalignant condition based on the presence of chromosomal alterations at one or more fragile chromosome sites. Methods of determining chromosomal alterations are disclosed. The present invention also relates to methods of establishing a prognosis and a therapeutic regimen for the... Agent: Nixon Peabody LLP - Patent Group
20090246787 - Method and apparatus for determining chemosensitivity: A method for determining chemosensitivity of a malignant tumor cell to anthracycline is described herein. According to this method, first tumor cell and second tumor sell are first prepared. The first tumor cell is not treated with anthracycline, and on the other the second tumor cell is treated with anthracycline.... Agent: Sughrue Mion, Pllc
20090246765 - Method and device for detecting target substance using probe carrier: A detecting device for detecting an enzyme present on a predetermined location on a substrate using a luminescence reaction, includes a mounting stage for mounting the substrate, a spotting means for locally applying a micro-droplet substance which contributes to a luminescence reaction with the enzyme onto a predetermined location on... Agent: Fitzpatrick Cella Harper & Scinto
20090246781 - Method for early determination of recurrence after therapy for prostate cancer: This invention describes compositions and methods for use in PSA assays having low functional sensitivity which are useful, for example, in the detection of early stage recurrence of prostate disease following treatment and in the determination of whether patients have early stage biochemical reoccurrence (ES-BCR) or stable disease.... Agent: Duane Morris LLP - San Diego
20090246764 - Method for the detection of group b streptococcus (gbs) (streptococcus agalactiae) in mammals: A method for the detection of all strains of Group B Streptococcus (GBS) (Streptococcus agalactiae) in a mammal comprises isolating nucleic acid from a biological sample obtained from the mammal, detecting in the isolated nucleic acid a specific target region of GBS ssrA gene or tmRNA, an RNA transcript of... Agent: Birch Stewart Kolasch & Birch
20090246784 - Method of analyzing methylated dna: The present invention provides a method of analyzing methylated DNA, comprising steps of: (A) treating a DNA-containing sample with a restriction enzyme to obtain a sample containing a DNA fragment; (B) concentrating methylated DNA contained in the sample obtained in step (A) to obtain a methylated DNA concentrate; (C) subjecting... Agent: Sughrue Mion, Pllc
20090246755 - Method of examining chemical using gene-disrupted strain: A method having higher sensitivity in a bioassay method utilizing cell response of a microorganism, for detecting the presence of a chemical in a test specimen is provided. The method of the present invention is characterized in that it uses specified gene-disrupted strains.... Agent: Global Ip Counselors, LLP
20090246783 - Method of measuring pyrophosphate: Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenase.... Agent: Birch Stewart Kolasch & Birch
20090246757 - Method, program, and system for normalizing gene expression amounts: The present invention aims at presenting novel means for analyzing and correcting gene expression amounts. There is provided a gene expression amount normalizing method in which the number of cells in a sample is obtained by measuring a repeated sequence present in a substantially fixed proportion in a genome contained... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090246788 - Methods and assays for capture of nucleic acids: The present disclosure provides methods and systems for sequence specific nucleic acid target capture comprising enzymatic reactions. The present disclosure relates to a plurality of oligonucleotide probes for capture and subsequent detection of target nucleic acid sequences, using flap endonucleases, ligases, and/or additional enzymes, proteins or compounds, on substrates, for... Agent: Barnes & Thornburg LLP
20090246792 - Methods for detecting nucleic acid sequence variations: The invention employs an unlabeled signal primer comprising a 5′ adapter sequence for detection of variations in nucleic acid target sequences. The detection system further comprises a reporter probe, the 3′ end of which hybridizes to the complement of the 5′ adapter sequence of the signal primer to produce a... Agent: David W. Highet, Vp & Chief Ip Counsel Becton, Dickinson And Company
20090246760 - Methods of equalizing representation levels of nucleic acid targets: The disclosure provides methods of reducing the range of representation levels of nucleic acid targets. The methods are particularly useful for multi-target analyses benefiting from a low variance of target representations, such as, e.g., single molecule sequencing and/or heterozygous genotyping, and pathogen diagnosis. Two general methods are provided. In Method... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090246776 - Modulators of scarb-1 for treating acne or hyperseborrhea: An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the SCARB-1 receptor, and the use of modulators of the expression or activity of this receptor for... Agent: Buchanan, Ingersoll & Rooney Pc
20090246769 - Molecular diagnosis of ovarian cancers: A molecular diagnosis system of ovarian cancers encompasses a detection device configured to obtain a detected value of an expression amount of an apolipoprotein A1 gene in ovarian tissue as a diagnosis subject, a storage device configured to store a normal value of the expression amount of the apolipoprotein A1... Agent: Sughrue Mion, Pllc
20090246772 - Novel dibenzo[c,h][1,5]naphthyridines and their use as dna probes: The present invention concerns novel dibenzo[c,h][1,5]naphthyridine of formula (I) and their use as DNA probes, as well as the methods for marking DNA using the same.... Agent: Stites & Harbison Pllc
20090246786 - Novel rat voltage-gated potassium channel: Disclosed herein are nucleic acid and polypeptide sequences of a novel rat voltage-gated potassium channel, KCNQ5. Also disclosed herein are methods related to the use of the aforementioned potassium channel.... Agent: Potter Anderson & Corroon LLP/wyeth Attn: Janet E. Reed, Ph.d.
20090246785 - Novel steroid 5-alpha-reductase: The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a... Agent: Hodgson Russ LLP The Guaranty Building
20090246762 - Nucleic acid terminators incorporating a cationic moiety and methods for their use: Disclosed are methods and kits applicable to sequencing methods, such as Sanger dideoxy sequencing methods. The methods and kits disclosed utilize a cationically charged nucleic acid terminator in combination with a discriminatory polymerase.... Agent: Patent Docket Department Armstrong Teasdale LLP
20090246758 - Peptide nucleic acid probes for analysis of microorganisms: The instant invention provides PNA probes for detection, identification and/or quantitation of microorganisms, e.g., Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Streptococcus agalactiae, fungi, and Acinetobacter species. The invention further provides methods of using the PNA probes of the invention and kits containing the PNA probes of the invention.... Agent: Edwards Angell Palmer & Dodge LLP
20090246768 - Predicting and diagnosing patients with autoimmune disease: The present invention provides methods for the prediction and diagnosis of autoimmune diseases, including Systemic Lupus Erythematosus, by identifying polymorphisms in the gene for MECP2.... Agent: Fulbright & Jaworski L.l.p.
20090246775 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 65 to 67 or a combination of at least two of... Agent: Fitzpatrick Cella Harper & Scinto
20090246790 - Prognostic panel for urinary bladder cancer: The present invention relates to methods of prognosing urothelial carcinoma. In one embodiment, the present invention provides a method of prognosing urothelial carcinoma by determining expression levels of JUN, MAP2K6, STAT3 and/or ICAM1. In another embodiment, the present invention provides an single prognostic panel made up of eight gene markers.... Agent: Davis Wright Tremaine LLP/los Angeles
20090246759 - Test and model for inflammatory disease: The present invention relates to a means and methods for determining susceptibility to SEEK1 mediated diseases, such as psoriasis. In addition, there is provided polynucleotides encoding the SEEK1 protein having one or more nucleotide insertions, deletions or substitutions at one or novel positions, and the SEEK1 protein having one or... Agent: Workman Nydegger 1000 Eagle Gate Tower
20090246756 - Thermostable polypeptide having polynucleotide kinase activity and/or phosphatase activity: Isolated polypeptides having 5′-kinase and/or 3′-phosphatase activity and temperature optimum of at least 60° C. are described. The invention also relates to isolated nucleic acids encoding the polypeptides, nucleic acid constructs and host cells comprising the nucleic acid sequences as well as methods using the polypeptides and kits for practicing... Agent: Birch Stewart Kolasch & Birch
20090246799 - Detection of chronic kidney disease patients or coronary artery disease using bone morphogenic protein-4: The invention is a method of detecting CAD in a CKD diagnosed human patient or CKD in a diagnosed CAD patient, or detection the presence of both CDK and CAD by assaying a plasma or serum sample of a human patient for elevated levels of BMP-4.... Agent: Jones, Walker, Waechter, Poitevent, Carrere & Denegre, L.l.p.
20090246795 - Immunoassay device and method: An immunoassay device capable of assaying amount of an antigen by allowing a labeled antibody to specifically bind to a antigen analyte in a sample and assaying a label of a bound product, an interior of a single device has four regions comprises: (1) a first region where the antigen... Agent: Global Ip Counselors, LLP
20090246800 - Immunoassay of analytes in samples containing endogenous anti-analyte antibodies: The disclosure provides among other things an assay method that compensates for the presence of endogenous antibodies, e.g., autoantibodies, which might otherwise compromise the measurement of an analyte in a biological sample. In one embodiment, this method entails the use of a two labeled entities: a labeled detection agent and... Agent: Paul D. Yasger Abbott Laboratories
20090246796 - Isolation and enumeration of cells from a complex sample matrix: The present invention relates to methods and systems for labeling, isolating, detecting and enumerating biological cells, or other biological analytes of interest present in a sample, where the capturing complex may also serve as a labeling agent. In one embodiment, the capture complex is an encoded magnetic bead coupled to... Agent: Fulbright & Jaworski L.l.p.
20090246797 - Medical device for the assessment of internal organ tissue and technique for using the same: A system for tissue ischemia detection is provided that may be used to assess markers of tissue ischemia. Such a system may include a sensor that may be used directly on internal tissue to assess ischemic condition. Sensors to be used in conjunction with the provided system may include optical,... Agent: Nellcor Puritan Bennett Llc Attn: Ip Legal
20090246798 - Method of detecting cancer and evaluating cancer prognosis: A method of detecting cancer in a subject is provided. One step of the method includes obtaining a bodily sample from the subject. Next, the level of pro-prion protein (pro-PrP) in the bodily sample is detected. The level of pro-PrP in the bodily sample is then compared to a control... Agent: Tarolli, Sundheim, Covell & Tummino, LLP
20090246794 - Methods and kit for detecting breast cancer: The present inventions relates to kits and methods for diagnosing and monitoring breast cancer. An increase in the level or activity of proteins of the ubiquitin/proteasome pathway, and ancillary proteins thereof, as compared to normal control or benign tissue is indicative of breast cancer.... Agent: Licata & Tyrrell P.c.
20090246801 - Rapid test for glycated albumin in blood: The test is performed using a disposable strip or cassette that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and... Agent: Stetina Brunda Garred & Brucker
20090246802 - Annexin-based apoptosis markers: The present invention describes an annexin derivative and a method of using the annexin derivative as a biosensor for real-time visualization of phosphatidylserine exposure, apoptosis, live-cell imaging and monitoring of cell health.... Agent: Davis Wright Tremaine LLP/los Angeles
20090246805 - Method for classifying and counting basophils: A method for counting basophils which comprises: (1) mixing and reacting a blood sample with an anti-CD123 antibody labeled with a first fluorescent label and an anti-CD294 antibody labeled with a second fluorescent label to prepare a measurement sample, (2) introducing the measurement sample into a flow cell of a... Agent: Sughrue Mion, Pllc
20090246806 - Coccidioides antigen immunoassay: The present disclosure relates to methods for detecting a Coccidioides in a physiological specimen. Methods, materials and kits relating to the detection of Coccidioides antigen by improved EIA methods are described.... Agent: Brinks Hofer Gilson & Lione/ann Arbor
20090246803 - Nad biosynthesis systems: The present invention generally relates to a nicotinamide adenine dinucleotide (NAD) biosynthesis system and methods of screening for NAD biosynthesis effectors. Among the various aspects of the present invention is the provision of an in vitro-reconstituted mammalian NAD biosynthesis system that can be used for the high-throughput screening of chemical... Agent: Senniger Powers LLP
20090246804 - Immuno gold lateral flow assay: A chromatographic specific binding assay strip device, comprising: a non-permeable platform strip; a permeable membrane testing strip positioned on top of said non-permeable platform strip, with the testing strip comprising at least one capture reagent site containing a capture reagent for at least one specific analyte, a sample receiving pad... Agent: Jonathan E. Grant/grant Patent Services
20090246807 - Method for quantitative measurements of hdl-c and ldl-c: The present invention relates to a method for direct measurement of high-density lipoprotein cholesterol. (HDL-C) or low-density lipoprotein cholesterol (LDL-C) based on a modified chemical precipitation method, wherein the improvements were made by optimizing the concentrations and proportions of potassium polyvinyl sulfate (PVSK) and polyethylene glycol methyl ether (PEGME) in... Agent: Sofer & Haroun LLP.
20090246808 - Biosensor with improved analyte specificity: A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP
20090246809 - Method of supporting a diagnosis of a risk of cancer recurrence, and a device of supporting a diagnosis of a risk of cancer recurrence: A method of supporting a diagnosis of a risk of cancer recurrence is disclosed. The method provides a new determining value a recurrence risk score (RRS) which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The risk of cancer recurrence is judged by... Agent: Sughrue Mion, Pllc
20090246810 - Use of mrp 8/14 levels for discrimination of individuals at risk of acute coronary syndromes: The present invention relates to a method for determining the risk whether an individual showing at least one symptom of an evolving acute coronary syndrome (ACS) is suffering from an acute coronary syndrome comprising the steps of (a) measuring, preferably in vitro, the level of MRP 8/14, wherein (b) if... Agent: Roche Diagnostics Operations Inc.
20090246811 - Dry analytical element for lipase measurement: The present invention provides a method for producing a dry analytical element for measurement of pancreatic lipase contained in a body fluid which contains triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerine measurement reagent, and comprises a water-impermeable support and... Agent: Birch Stewart Kolasch & Birch
20090246812 - Dry analytical element for lipase measurement: It is an object of the present invention to provide: a dry analytical element for analyzing pancreatic lipase wherein the triglyceride is not transcribed on the support to contaminate a transportation slip or other analytical elements and wherein an additive solution of the triglyceride neither reaggregates nor precipitate, so that... Agent: Birch Stewart Kolasch & Birch
20090246813 - Selective acceleration of fragmentation through joint application of enzymes and ultrasound: The present invention refers to an acceleration process for macromolecular fragmentation in liquid medium, in gel or in a solid support, by means of joint application of enzymes and ultrasounds, as well as isotopes. The macromolecules, in any of these liquids, are mixed with enzymes and inserted in a recipient... Agent: Sughrue Mion, Pllc
20090246815 - Protease detection material, set of protease detection materials, and method for measuring protease: The present invention provides a protease detection material having, on a support, at least a layer containing a dye precursor and a layer which contains a protease substrate and is disposed on the same side of the support as the layer containing the dye precursor and farther from the support... Agent: Birch Stewart Kolasch & Birch
20090246814 - Reagent for digestion of hemoglobin: The present invention relates to a reagent for digestion of hemoglobin comprising a buffer, pepsin and a 1,3-dialkyl-imidazolium salt. It also discloses to the use of this reagent in a method for digesting hemoglobin, in a method for detecting HbA1c, and to a sampling tube for collection of a whole... Agent: Roche Diagnostics Operations Inc.
20090246817 - Dry analytical element capable of reducing influence of hemolysis for body fluid component measurement: It is an object of the present invention to reduce influence of hemolysis in a dry analytical element used for measurement of components in a body fluid sample such as blood. The present invention provides a method for producing a dry analytical element for body fluid component measurement comprising at... Agent: Birch Stewart Kolasch & Birch
20090246816 - Methods and kits for selecting an analgesic regime: A method is provided for selecting an analgesic regime for treatment of a patient. In the method, a body fluid sample from the patient is assayed for the presence of a metabolite produced by metabolism of a prodrug. If the metabolite is present in the body fluid sample this indicates... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP
20090246818 - Compounds, methods, complexes, apparatuses and uses relating to stabile forms of nad/nadh: The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.... Agent: Roche Diagnostics Operations Inc.
20090246819 - Assay methods using chemiluminescent detection of peroxidase: Methods for generating chemiluminescence rapidly by reaction of at least one compound comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups with a peroxidase enzyme and a peroxide are disclosed. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase... Agent: Lumigen, Inc./beckman Coulter, Inc.
20090246820 - Compounds useful in cftr assays and methods therewith: The present invention relates to compounds useful in CFTR assays. The present invention also relates to compounds useful in monitoring CFTR activity in therapies for CFTR-mediated diseases. The present invention also provides an assay for use in measuring CFTR correction.... Agent: Vertex Pharmaceuticals Inc.
20090246821 - Peroxiredoxin drugs for treatment of hiv-1 infection and methods of use thereof: The invention includes compositions comprising substantially purified peroxiredoxin that are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies... Agent: Burns & Levinson, LLP
20090246822 - Composition for cell permeabilization comprising nog, hmp, rubidium chloride and/or lithium chloride for detecting living cells on a membrane: The present invention relates to a composition for the permeabilization of the walls of microorganisms comprising the combination of octyl-β-D-glucopyranoside (NOG), sodium polyphosphates (HMP), and a salt chosen from lithium chloride or rubidium chloride, and a method for the enumeration and identification of cells on a membrane using said composition.... Agent: Nields, Lemack & Frame, Llc
20090246823 - Evaluation methodology of the protection characteristics of personal protective equipments against biological agents: New testing methodology for the evaluation of the protection of the Personal Protective Equipments (PPE) for the respiratory tract against biological agents, characterized in that different machineries are used to reproduce the usage of the PPE, simulating a breathing through the Sheffield's head and self-respirator. The apparatus consists of: a)... Agent: Young & Thompson
20090246825 - Method for processing a tissue specimen in situ prior to histological examination: The present invention is directed to a method for processing a tissue specimen in situ prior to histological examination by providing a tissue specimen having a predetermined examination face, disposing the specimen on a tissue positioning member for removably maintaining the tissue specimen with the examination face in a desired... Agent: Thompson Coburn LLP
20090246824 - Methods for integrated tissue processing and staining: Methods that combine processing and staining of tissue samples such that the processed tissue is stained and ready for histological evaluation prior to embedding and sectioning, and separate staining of the sectioned tissue is not required. The method may be used with chemical and/or mechanical/thermal tissue penetrant enhancers in an... Agent: Thompson Hine L.l.p. Intellectual Property Group
20090246826 - Bi-directional selection markers with improved activity: The present invention discloses a polypeptide selected from the group consisting of: a polypeptide having an amino acid sequence according to SEQ ID NO 3, a polypeptide having an amino acid sequence according to SEQ ID NO 6, a polypeptide having an amino acid that is substantially homologous to the... Agent: Nixon & Vanderhye, Pc
20090246827 - Recombinant toxin fragments: A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the... Agent: Morris Manning Martin LLP
20090246828 - Arabinose isomerase expressed from corynebacterium genus and tagatose manufacturing method by using it: The present invention relates to a thermophilic arabinose isomerase and a method of manufacturing tagatose using the same, and more precisely, a gene encoding arabinose isomerase originating from the thermophile Thermotoga neapolitana DSM 5068, a recombinant expression vector containing the gene, a method of preparing a food grade thermophilic arabinose... Agent: Occhiuti Rohlicek & Tsao, LLP
20090246829 - Sequence analysis of the tetravalent rotavirus vaccine: Isolated nucleic acid molecules comprising a gene segment from a rhesus rotavirus (RRV) or from one of three rhesus:human reassortant viruses are disclosed, including isolated nucleic acid molecules having a sequence selected from the group consisting of: SEQ ID NO: 1-14, inclusive, and isolated nucleic acid molecules encoding a protein... Agent: Townsend And Townsend And Crew, LLP
20090246830 - Recombinant influenza viruses for vaccines and gene therapy: A method for producing influenza virus particles for preparation of a vaccine. The method comprises growing reassortant influenza viruses to produce virus particles and recovering the produced virus particles. The reassortant influenza viruses are produced in cultured cells in the absence of helper virus by introducing into the cultured cells... Agent: Sughrue Mion, Pllc
20090246831 - Methods for recombinant peptide production: The present invention provides improved methods for the production of recombinant peptides from bacterial cells.... Agent: John M. Polo Xoma (us) Llc
20090246832 - Production of polysialic acid containing glycoconjugates using a self-priming polysialyltransferase: The invention relates to a fusion protein comprising a bifunctional sialytransferase and a poly-sialytransferase and methods to use the fusion proteins for production of poly-sialylated end products, e.g. oligosaccharides and glycoproteins.... Agent: Townsend And Townsend And Crew, LLP
20090246833 - Small interfering rnas as non-specific drugs: The present invention is directed to a method of modulating (e.g., inducing, inhibiting) activation of a double stranded RNA (dsRNA) signaling pathway, such as the dsRNA signaling pathway that accompanies RNA interference (RNAi) of a target RNA sequence, in a cell, comprising introducing into the cell small interfering RNA (siRNA)... Agent: Hamilton, Brook, Smith & Reynolds, P.c.
20090246834 - Nano-pcr: methods and devices for nucleic acid amplification and detection: Methods, devices, and compositions are described that provide for amplification of nucleic acid sequences without reliance upon temperature cycling, thus freeing the methods from conventional benchtop thermal cycling devices. Denaturation of double stranded nucleic acids, primer annealing, and precision control over primer extension by polymerase can be accomplished by applying... Agent: Hamilton, Brook, Smith & Reynolds, P.c.
20090246835 - l-amino acid-producing bacterium and a method for producing an l-amino acid: An L-amino acid is produced by culturing a microorganism of the family Enterobacteriaceae which has the ability to produce an L-amino acid and which has been modified so as to increase the expression of the evgA gene, the gadE gene, and/or the ydeO gene. These genes encode a transcription factor... Agent: Cermak & Kenealy LLP Acs Llc
20090246836 - Pgro expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090246837 - Process for the preparation of optically active chiral amines: The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.... Agent: Harness, Dickey & Pierce, P.L.C
20090246838 - Process for the production of cadaverine: Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA... Agent: Connolly Bove Lodge & Hutz, LLP
20090246839 - Enzymatic modification of triglyceride fats: Process wherein the fatty acid residues on a glyceride moiety are randomised over the terminal and middle positions, wherein the process proceeds to a conversion degree on the terminal positions, Re, ranging from 0.3 to 0.95, and wherein a conversion degree on the middle position, Ra, ranges from 0.06 to... Agent: Unilever Patent Group
20090246840 - Process for producing isomer enriched conjugated linoleic acid compositions: A process for the preparation of a composition comprising the cis9, trans11 and trans10, cis12 isomers of conjugated linoleic acid (CLA) comprises: providing a mixture comprising cis9, trans11 and trans10, cis12 isomers of conjugated linoleic acid (CLA) in which one of the cis9, trans11 and trans10, cis12 isomers is present... Agent: Morgan Lewis & Bockius LLP
20090246841 - Methods and compositions for production of acetaldehyde: The present disclosure provides methods for producing acetaldehyde from renewable biological resources, for example, from a fermentable substrate, with the advantages of energy efficiency and ease of purification. Particular embodiments, feature the production of acetaldehyde from pyruvate, wherein the pyruvate is generated from various carbon sources (e.g., sugars) by pyruvate-producing... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090246842 - Engineered microorganisms for producing propanol: Methods and compositions for the production of bio-based material precursors are provided.... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090246843 - Process for producing erythritol using moniliella tomentosa strains in the presence of neutral inorganic nitrates, such as potassium nitrate, ammonium nitrate or sodium nitrate, as nitrogen source: The present invention relates to the use of at least one inorganic nitrate in a fermentation process for producing erythritol using a yeast strain of the Moniliella species as an erythritol-producing microorganism characterized in that the at least one inorganic nitrate is simultaneously used as a main nitrogen source and... Agent: Paul And Paul
20090246845 - Glucoamylase and buttiauxiella phytase during saccharification: Described are compositions and methods relating to the use of a glucoamylase in combination with a phytase in starch processing to reduce the levels of phytic acid in end-products.... Agent: Danisco Us Inc. Genencor Division
20090246847 - Method for producing ethanol from steam exploded sweet potato by fermentation: A method for producing ethanol from steam-exploded sweet potato by fermentation includes subjecting sweet potato to a steam explosion treatment, subjecting the sweet potato after the steam explosion to saccharification and fermentation, and collecting ethanol produced by the fermentation. The sweet potato can optionally be subjected to a pre-treatment utilizing... Agent: Knobbe Martens Olson & Bear LLP
20090246844 - Methods for the production of ethanol: Embodiments of the present invention include methods for the production of ethanol, by a consolidated bioprocessing approach for the conversion of cellulosic material. According to some embodiments, recombinant microbial host cells are provided, preferably S. cerevisiae, that are capable of converting cellulosic material to ethanol and include cellulase genes. According... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo
20090246846 - Zymomonas with improved xylose utilization: Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090246848 - Process and apparatus for dewatering cellulosic fermentation products: A liquid mixture of water and a small percentage of an alcohol, for example a cellulosic fermentation broth, is converted into a mixture of vapours. The vapour mixture includes an increased percentage of alcohol vapour relative to the liquid mixture but is mostly water vapour. Water vapour is removed from... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.
20090246849 - Biogenic methane production enhancement systems: Systems for enhanced in-situ or perhaps even ex-situ biogenic methane production from hydrocarbon-bearing formations (1) including coal seam, oil shale, coal, coal derivates and the like are presented in embodiments such as but not limited to: increasing and perhaps even selection of microbial populations (2), amending CBM water and other... Agent: Santangelo Law Offices, P.c.
20090246850 - Method for biocatalysis using filamentous fungi: A method is disclosed in which filamentous fungi are macerated and encapsulated in an inert matrix to form beads, which can be used to promote reactions carried out by the fungi. The beads are useful, e.g., for producing compounds and compound libraries.... Agent: Wilmerhale/boston
20090246851 - Method for production of enzyme: The present invention provides a process for producing an enzyme, which includes recovering an enzyme by microfiltering an enzyme-containing solution, having a cell density of 1% (v/v) or less and an enzyme concentration of 1% (w/v) or more in terms of the amount of proteins, with a cationic surfactant added... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.
20090246852 - Therapeutic use of anti-cs1 antibodies: The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including... Agent: Dechert LLP
20090246853 - Directed evolution method: We describe a method of selecting an enzyme having replicase activity, the method comprising the steps of: (a) providing a pool of nucleic acids comprising members each encoding a replicase or a variant of the replicase; (b) subdividing the pool of nucleic acids into compartments, such that each compartment comprises... Agent: Edwards Angell Palmer & Dodge LLP
20090246855 - Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences: The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a... Agent: Jones Day
20090246854 - Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same: The invention relates to a scleroprotein of an adeno-associated virus which contains at least one mutation. Said mutation causes the chromatographic properties to be modified. The invention also relates to the production of said scleroprotein and the use thereof.... Agent: Clark & Elbing LLP
20090246857 - Stable recombinant yeasts for fermenting xylose to ethanol: Described are recombinant yeast which ferment xylose to ethanol and which maintain their ability to do so when cultured for numerous generations in non-selective media. The preferred yeast contain multiple copies of integrated genes encoding xylose reductase, xylitol dehydrogenase, and xylulokinase fused to promoters which are non-glucose inhibited and which... Agent: Mueting, Raasch & Gebhardt, P.a.
20090246856 - Trichoderma reesei phytase enzymes, nucleic acids encoding such phytase enzymes, vectors and host cells incorporating same and methods of making and using same: A novel DNA is provided which encodes an enzyme having phytase activity isolated from Trichoderma. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA... Agent: Danisco Us Inc. Attention: Legal Department
20090246858 - Drain treatment system: A drain treatment system includes a puck containment basket having an open top, sides, a bottom attached to the sides, and a rim attached to the sides at the open top. The sides and bottom of the puck containment basket have openings to permit liquid flow while restricting passage of... Agent: Fulbright And Jaworski LLP
20090246859 - Methods and compositions for purification of nucleic acid from a host cell: Methods and compositions are provided for gently lysing and solubilizing cells. Methods and compositions are further provided for quickly purifying high quality low molecular weight nucleic acid from host cells. Target cells are treated with a pre-chilled lysis solution having a zwitterionic detergent, for example n-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate, and a brief room-temperature... Agent: King Spalding LLP
20090246860 - Point source diffusion cell activity assay apparatus: Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from a point source,... Agent: Paul, Hastings, Janofsky & Walker LLP
20090246861 - Chromatographic test device: A chromatographic test device comprising, in the order of passage of a sample containing blood cell components and liquid components, a label holding member provided with a labeling substance capable of binding specifically to an analyte contained in the liquid components, a blood cell separation member for separating predetermined blood... Agent: Sughrue Mion, Pllc
20090246862 - Bioluminogenic assay system for measuring beta-lactamase activity: A bioluminogenic assay system including: providing a bioluminogenic substrate incorporating a beta-lactam antibiotic, a bioluminescence initiating compound, and a chemical linkage joining the beta-lactam antibiotic to the bioluminescence initiating compound; exposing the bioluminogenic substrate to a beta-lactamase enzyme that catalyzes the release of the bioluminescence initiating compound from the bioluminogenic... Agent: Law Offices Of Mikio Ishimaru
20090246863 - Apparatus for cultivating oil-rich microalgae: An apparatus for cultivating oil-rich microalgae includes a tank having a cultivation medium held therein for cultivating the oil-rich microalgae, the tank being provided at predetermined positions with at least one feeding pipe for feeding carbon dioxide and other nutrients to the tank and at least one drain pipe for... Agent: Wpat, Pc Intellectual Property Attorneys
20090246864 - Cell culture device and methods for manufacturing and using the cell culture device: A cell culture device, a method for manufacturing the cell culture device using an In Mold Labeling (IML) technique, and a method for using the cell culture device are all described herein. The cell culture device is an In Line Molded frame which has a cell growth film permanently bonded... Agent: Corning Incorporated
20090246865 - Porous film: A porous film is used as a cell culture substrate that is a scaffold for a spheroid. The porous film has a plurality of pores whose diameters gradually increase in a direction A. The diameters of the pores gradually increase from a first area P1 to a third area P3... Agent: Sughrue Mion, Pllc
20090246866 - Ready-to-use whole blood collection vessel: The present invention relates to a sampling tube for collecting and processing a whole blood sample. The sampling tube contains a reagent for differential hemolysis of whole blood, wherein said reagent for differential hemolysis comprises a chemical for differential hemolysis and an anti-coagulant, and wherein said sampling tube is a... Agent: Roche Diagnostics Operations Inc.
20090246867 - Glial mitogenic factors, their preparation and use: Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors.... Agent: Klauber & Jackson
20090246868 - Serum-free vero cell banking process: A serum-free Vero cell banking process provides a standardized and consistent way to generate reliable and stable cell banks for viral vaccine production. The substitution of animal-derived substances with plant-derived substances in the growth and freezing media increases the viability of the cells upon thawing and reduces their recovery time,... Agent: Wyeth Patent Law Group
20090246869 - Differentiation of primate pluripotent stem cells to hematopoietic lineage cells: The invention provides methods of differentiating primate pluripotent stem cells into cells of hematopoietic lineage. The invention further provides hematopoietic lineage cells differentiated from primate pluripotent stem cells, as well as methods of using the same and kits comprising the same.... Agent: Geron Corporation Attn. David J. Earp
20090246871 - Container for germ layer formation and method of forming germ layer: The invention relates to a vessel for embryoid formation used for forming embryoid bodies from ES cells easily without complicated technique, and to a method for forming embryoid bodies easily and efficiently using the vessel. The method includes the steps of (A) providing a vessel for embryoid formation having a... Agent: Sughrue Mion, Pllc
20090246870 - De-differentiation of astrocytes into neural stem cell using nanog: Disclosed are a composition and a method for inducing the de-differentiation of astrocytes into neural stem cells using Nanog. The de-differentiated neural stem cells have the ability to differentiate into astrocytes, neurons, or oligodendrocytes.... Agent: Bozicevic, Field & Francis LLP
20090246873 - Scaffold for tissue engineering and production method thereof: To provide a scaffold for tissue engineering which consists of a bioabsorbable polymer material to be absorbed in a biotissue, and holds strength of the whole scaffold while having a porosity proper for culturing cells inside thereof as well, a method for producing the scaffold for tissue engineering includes steps... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.
20090246872 - Structure for cell culture, cell culture vessel, structure with spheroid, vessel with spheroid, and manufacturing methods thereof: By using a microfabrication technique such as nanoimprinting, a structure for cell culture comprising: a concavo-convex structure having a plurality of successive unit structures each formed in a polygonal shape in a planar direction and having a minimum internal diameter of less than or equal to 3 μm, wherein a... Agent: Factor & Lake, Ltd
20090246874 - Method and device for culturing neural cells: A method and device are provided for culturing neural cells within a microfluidic device. A layer of predetermined material is deposited on a substrate and a cartridge is positioned on the substrate. The cartridge defines a first channel communicating with the predetermined material; a chamber communicating with the first channel... Agent: Wisconsin Alumni Research Foundation
20090246875 - Efficient method for nuclear reprogramming: This relates to a method of preparing induced pluripotent stem cells, comprising a nuclear reprogramming step with a nuclear reprogramming factor in the presence of miRNA, wherein said miRNA has a property of providing a higher nuclear reprogramming efficiency in the presence of said miRNA than in the absence thereof.... Agent: Greenblum & Bernstein, P.L.C
20090246876 - High expression zymomonas promoters: Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.... Agent: E I Du Pont De Nemours And Company Legal Patent Records CenterPrevious industry: Education and demonstration
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