Chemistry: molecular biology and microbiology inventions 10/09

20090246750 - Devices and methods for collection, storage and transportation of biological specimens: The present invention provides methods for collecting, storing or transporting liquid suspension of biological specimens containing analytes of interest in a dry state. The dried biological specimens containing analytes of interest are reconstituted and released for subsequent analysis by compressing or centrifuging the matrix. Also provided are method of using... Agent: Sutherland Asbill & Brennan LLP

20090246752 - Apparatus and method for detecting microscopic living organisms using bacteriophage: A method for detecting one or more target bacteria in a raw sample where: 1) bacteriophage(s) specific to each target bacterium are added to the raw sample, 2) the test sample is incubated, and 3) the test sample is tested for the presence of each phage in sufficient numbers to... Agent: Patton Boggs LLP

20090246753 - Detection of phage amplification by sers nanoparticles: A phage specific antibody presenting particle, devices and methods related to detection of phage amplification are provided.... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20090246751 - Method for the detection of virus infected cells: The present invention relates to a method for determining one or more stressed cell(s) in a medium. The method comprises the steps of (i) providing a sample from the medium, and (ii) determining a change in the sample relative to a normal sample of non-stressed cell(s).... Agent: Foley And Lardner LLP Suite 500

20090246754 - Optimized probes and primers and methods of using same for the detection and quantitation of bk virus: Described herein are probes and primers for detecting and quantitating variant BK viral strains and methods and devices of identifying and using the described probes and primers.... Agent: Intelligent Medical Devices, Inc. C/o Foley & Lardner LLP

20090246777 - Allelic discrimination analysis using an efficiency related value (efr): In various embodiments this invention provides novel methods for discriminating two or more different target nucleic acids. In certain embodiments the methods comprise providing data amplification reactions comprising reagents to amplify two or more different target nucleic acids where the data comprise signals comprising an amplitude measurement representing the degree... Agent: Weaver Austin Villeneuve & Sampson LLP

20090246782 - Barriers for facilitating biological reactions: The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes.... Agent: Casimir Jones, S.c.

20090246774 - Chromosomal blocks as markers for traits: The present invention provided a method for predicting a phenotype in a bovine animal, the method comprising analysing a nucleic acid sample from said animal for the presence of at least one genetic marker known to reside in an Linkage Disequilibrium (LD) block in any one of bovine chromosomes BTA-I... Agent: Fish & Richardson P.c.

20090246771 - Compositions and methods comprising biomarkers of sperm quality, semen quality and fertility: Provided are compositions and methods for determining or diagnosing abnormal sperm or fertility, comprising: obtaining sperm DNA from a test subject; determining the methylation status of at least one CpG dinucleotide sequence of at least one gene sequence selected from HRAS, NTF3, MT1A, PAX8, DIRAS3, PLAGL1, SFN, SAT2CHRM1, MEST, RNR1,... Agent: Davis Wright Tremaine, LLP/seattle

20090246767 - Compositions and methods for detecting cryptococcus neoformans: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Cryptococcus neoformans, a causative agent for human cryptococcosis. These oligonucleotides, which have nucleotide sequences derived from a coding segment of the gene encoding the fungal specific transcription factor gene in Cryptococcus neoformans, are useful as forward and reverse... Agent: Medical Diagnostic Laboratories, Llc

20090246793 - Cudr as biomarker for cancer progression and therapeutic response: Disclosed is a novel human gene designated CUDR. Provides is also a CUDR gene as a biomarker in the diagnosis of human cancers and a cancer therapy.... Agent: Knobbe Martens Olson & Bear LLP

20090246761 - Development of prognostic markers from the saliva of head and neck cancer patients: The present invention relates to biomarkers that are useful for the detection of cancer. The invention further relates to biomarkers and methods of using biomarkers for the early detection of head and neck cancer.... Agent: Hogan & Hartson L.l.p.

20090246773 - Diagnostic compositions and treatment methods for conditions involving trophoblast cell death, differentiation, invasion and/or cell fusion and turnover: The invention provides a method for diagnosing in a subject a condition requiring modulation of or involving trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, comprising detecting HIF Iα and the factors which modulate or are modulated by this protein, specifically TGFβ3, sFLT, VEGF, SMAD2, 3 and 7,... Agent: Howson & Howson LLP

20090246763 - Electrochemical labels derived from siderophores: Disclosed are tri-nuclear metal complexes and salts thereof, such as tri-nuclear osmium or ruthenium complexes or salts thereof, suitable for use as electrochemical labels. Also disclosed are oligonucleotide probes with an attached electrochemical label, methods of nucleic acid amplification, methods of sequencing, and kits for nucleic acid amplification and sequencing... Agent: Patent Docket Department Armstrong Teasdale LLP

20090246791 - Engineered fluorescent dye labeled nucleotide analogs for dna sequencing: Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the nucleotide analogs. Kits, methods and systems are provided for analysis of nucleic acid synthesis reactions.... Agent: Pacific Biosciences Of California, Inc.

20090246789 - Gene mutation profiling of csmd1: A method for assessing risk of node-positive colorectal cancer in an individual is described. The method includes detecting mutations in CSMD1 genes in a tumor sample from the individual, the mutations being associated with increased risk of node-positive colorectal cancer.... Agent: Dority & Manning, P.a.

20090246770 - Glycemic control for reduction of cardiovascular disease risk in diabetic patients expressing haptoglobin 2-2: This invention relates to methods of reducing risk of developing cardiovascular complications in diabetic patients. Specifically, the invention relates to the use of haptoglobin genotyping for determining the importance of maintaining tight glycemic control in diabetic subjects expressing Hp 2-2 allele.... Agent: Pearl Cohen Zedek Latzer, LLP

20090246780 - High throughput physical mapping using aflp: The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor compatible primers carrying selective nucleotides at their 3′ end. The... Agent: Foley And Lardner LLP Suite 500

20090246766 - High throughput screening of genetically modified photosynthetic organisms: The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of producing one or more proteins, including biomass degrading enzymes in a plant. Also provided are the methods of producing biomass degradation pathways in alga... Agent: Quine Intellectual Property Law Group, P.c.

20090246778 - Identification of fat and lean phenotypes in chickens using molecular markers: The present invention identifies genetic markers for lean and fat phenotypes in chickens and provides methods of screening chickens to determine those more likely to have a lean or fat phenotype. The invention also provides methods of screening chickens to identify a polymorphism in THRSPα associated with a fat or... Agent: Ratnerprestia

20090246779 - Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-cgh: The present invention relates to a method of diagnosing a premalignant condition based on the presence of chromosomal alterations at one or more fragile chromosome sites. Methods of determining chromosomal alterations are disclosed. The present invention also relates to methods of establishing a prognosis and a therapeutic regimen for the... Agent: Nixon Peabody LLP - Patent Group

20090246787 - Method and apparatus for determining chemosensitivity: A method for determining chemosensitivity of a malignant tumor cell to anthracycline is described herein. According to this method, first tumor cell and second tumor sell are first prepared. The first tumor cell is not treated with anthracycline, and on the other the second tumor cell is treated with anthracycline.... Agent: Sughrue Mion, Pllc

20090246765 - Method and device for detecting target substance using probe carrier: A detecting device for detecting an enzyme present on a predetermined location on a substrate using a luminescence reaction, includes a mounting stage for mounting the substrate, a spotting means for locally applying a micro-droplet substance which contributes to a luminescence reaction with the enzyme onto a predetermined location on... Agent: Fitzpatrick Cella Harper & Scinto

20090246781 - Method for early determination of recurrence after therapy for prostate cancer: This invention describes compositions and methods for use in PSA assays having low functional sensitivity which are useful, for example, in the detection of early stage recurrence of prostate disease following treatment and in the determination of whether patients have early stage biochemical reoccurrence (ES-BCR) or stable disease.... Agent: Duane Morris LLP - San Diego

20090246764 - Method for the detection of group b streptococcus (gbs) (streptococcus agalactiae) in mammals: A method for the detection of all strains of Group B Streptococcus (GBS) (Streptococcus agalactiae) in a mammal comprises isolating nucleic acid from a biological sample obtained from the mammal, detecting in the isolated nucleic acid a specific target region of GBS ssrA gene or tmRNA, an RNA transcript of... Agent: Birch Stewart Kolasch & Birch

20090246784 - Method of analyzing methylated dna: The present invention provides a method of analyzing methylated DNA, comprising steps of: (A) treating a DNA-containing sample with a restriction enzyme to obtain a sample containing a DNA fragment; (B) concentrating methylated DNA contained in the sample obtained in step (A) to obtain a methylated DNA concentrate; (C) subjecting... Agent: Sughrue Mion, Pllc

20090246755 - Method of examining chemical using gene-disrupted strain: A method having higher sensitivity in a bioassay method utilizing cell response of a microorganism, for detecting the presence of a chemical in a test specimen is provided. The method of the present invention is characterized in that it uses specified gene-disrupted strains.... Agent: Global Ip Counselors, LLP

20090246783 - Method of measuring pyrophosphate: Provided is a novel and useful method of measuring pyrophosphate in a sample. There may be provided a novel and useful method of measuring pyrophosphate in a sample using pyruvate orthophosphate dikinase, nicotinamide-nucleotide adenylyltransferase, and dehydrogenase.... Agent: Birch Stewart Kolasch & Birch

20090246757 - Method, program, and system for normalizing gene expression amounts: The present invention aims at presenting novel means for analyzing and correcting gene expression amounts. There is provided a gene expression amount normalizing method in which the number of cells in a sample is obtained by measuring a repeated sequence present in a substantially fixed proportion in a genome contained... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090246788 - Methods and assays for capture of nucleic acids: The present disclosure provides methods and systems for sequence specific nucleic acid target capture comprising enzymatic reactions. The present disclosure relates to a plurality of oligonucleotide probes for capture and subsequent detection of target nucleic acid sequences, using flap endonucleases, ligases, and/or additional enzymes, proteins or compounds, on substrates, for... Agent: Barnes & Thornburg LLP

20090246792 - Methods for detecting nucleic acid sequence variations: The invention employs an unlabeled signal primer comprising a 5′ adapter sequence for detection of variations in nucleic acid target sequences. The detection system further comprises a reporter probe, the 3′ end of which hybridizes to the complement of the 5′ adapter sequence of the signal primer to produce a... Agent: David W. Highet, Vp & Chief Ip Counsel Becton, Dickinson And Company

20090246760 - Methods of equalizing representation levels of nucleic acid targets: The disclosure provides methods of reducing the range of representation levels of nucleic acid targets. The methods are particularly useful for multi-target analyses benefiting from a low variance of target representations, such as, e.g., single molecule sequencing and/or heterozygous genotyping, and pathogen diagnosis. Two general methods are provided. In Method... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090246776 - Modulators of scarb-1 for treating acne or hyperseborrhea: An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the SCARB-1 receptor, and the use of modulators of the expression or activity of this receptor for... Agent: Buchanan, Ingersoll & Rooney Pc

20090246769 - Molecular diagnosis of ovarian cancers: A molecular diagnosis system of ovarian cancers encompasses a detection device configured to obtain a detected value of an expression amount of an apolipoprotein A1 gene in ovarian tissue as a diagnosis subject, a storage device configured to store a normal value of the expression amount of the apolipoprotein A1... Agent: Sughrue Mion, Pllc

20090246772 - Novel dibenzo[c,h][1,5]naphthyridines and their use as dna probes: The present invention concerns novel dibenzo[c,h][1,5]naphthyridine of formula (I) and their use as DNA probes, as well as the methods for marking DNA using the same.... Agent: Stites & Harbison Pllc

20090246786 - Novel rat voltage-gated potassium channel: Disclosed herein are nucleic acid and polypeptide sequences of a novel rat voltage-gated potassium channel, KCNQ5. Also disclosed herein are methods related to the use of the aforementioned potassium channel.... Agent: Potter Anderson & Corroon LLP/wyeth Attn: Janet E. Reed, Ph.d.

20090246785 - Novel steroid 5-alpha-reductase: The invention provides an isolated, novel steroid 5α-reductase enzyme termed SRD5AIII. The protein has an estimated molecular weight of 37 kDa and is capable of converting testosterone to dihydrotestosterone at a pH of about 7.0. Also provided is a method for identifying inhibitors of SRD5AIII by contacting SRD5AIII with a... Agent: Hodgson Russ LLP The Guaranty Building

20090246762 - Nucleic acid terminators incorporating a cationic moiety and methods for their use: Disclosed are methods and kits applicable to sequencing methods, such as Sanger dideoxy sequencing methods. The methods and kits disclosed utilize a cationically charged nucleic acid terminator in combination with a discriminatory polymerase.... Agent: Patent Docket Department Armstrong Teasdale LLP

20090246758 - Peptide nucleic acid probes for analysis of microorganisms: The instant invention provides PNA probes for detection, identification and/or quantitation of microorganisms, e.g., Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Streptococcus agalactiae, fungi, and Acinetobacter species. The invention further provides methods of using the PNA probes of the invention and kits containing the PNA probes of the invention.... Agent: Edwards Angell Palmer & Dodge LLP

20090246768 - Predicting and diagnosing patients with autoimmune disease: The present invention provides methods for the prediction and diagnosis of autoimmune diseases, including Systemic Lupus Erythematosus, by identifying polymorphisms in the gene for MECP2.... Agent: Fulbright & Jaworski L.l.p.

20090246775 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 65 to 67 or a combination of at least two of... Agent: Fitzpatrick Cella Harper & Scinto

20090246790 - Prognostic panel for urinary bladder cancer: The present invention relates to methods of prognosing urothelial carcinoma. In one embodiment, the present invention provides a method of prognosing urothelial carcinoma by determining expression levels of JUN, MAP2K6, STAT3 and/or ICAM1. In another embodiment, the present invention provides an single prognostic panel made up of eight gene markers.... Agent: Davis Wright Tremaine LLP/los Angeles

20090246759 - Test and model for inflammatory disease: The present invention relates to a means and methods for determining susceptibility to SEEK1 mediated diseases, such as psoriasis. In addition, there is provided polynucleotides encoding the SEEK1 protein having one or more nucleotide insertions, deletions or substitutions at one or novel positions, and the SEEK1 protein having one or... Agent: Workman Nydegger 1000 Eagle Gate Tower

20090246756 - Thermostable polypeptide having polynucleotide kinase activity and/or phosphatase activity: Isolated polypeptides having 5′-kinase and/or 3′-phosphatase activity and temperature optimum of at least 60° C. are described. The invention also relates to isolated nucleic acids encoding the polypeptides, nucleic acid constructs and host cells comprising the nucleic acid sequences as well as methods using the polypeptides and kits for practicing... Agent: Birch Stewart Kolasch & Birch

20090246799 - Detection of chronic kidney disease patients or coronary artery disease using bone morphogenic protein-4: The invention is a method of detecting CAD in a CKD diagnosed human patient or CKD in a diagnosed CAD patient, or detection the presence of both CDK and CAD by assaying a plasma or serum sample of a human patient for elevated levels of BMP-4.... Agent: Jones, Walker, Waechter, Poitevent, Carrere & Denegre, L.l.p.

20090246795 - Immunoassay device and method: An immunoassay device capable of assaying amount of an antigen by allowing a labeled antibody to specifically bind to a antigen analyte in a sample and assaying a label of a bound product, an interior of a single device has four regions comprises: (1) a first region where the antigen... Agent: Global Ip Counselors, LLP

20090246800 - Immunoassay of analytes in samples containing endogenous anti-analyte antibodies: The disclosure provides among other things an assay method that compensates for the presence of endogenous antibodies, e.g., autoantibodies, which might otherwise compromise the measurement of an analyte in a biological sample. In one embodiment, this method entails the use of a two labeled entities: a labeled detection agent and... Agent: Paul D. Yasger Abbott Laboratories

20090246796 - Isolation and enumeration of cells from a complex sample matrix: The present invention relates to methods and systems for labeling, isolating, detecting and enumerating biological cells, or other biological analytes of interest present in a sample, where the capturing complex may also serve as a labeling agent. In one embodiment, the capture complex is an encoded magnetic bead coupled to... Agent: Fulbright & Jaworski L.l.p.

20090246797 - Medical device for the assessment of internal organ tissue and technique for using the same: A system for tissue ischemia detection is provided that may be used to assess markers of tissue ischemia. Such a system may include a sensor that may be used directly on internal tissue to assess ischemic condition. Sensors to be used in conjunction with the provided system may include optical,... Agent: Nellcor Puritan Bennett Llc Attn: Ip Legal

20090246798 - Method of detecting cancer and evaluating cancer prognosis: A method of detecting cancer in a subject is provided. One step of the method includes obtaining a bodily sample from the subject. Next, the level of pro-prion protein (pro-PrP) in the bodily sample is detected. The level of pro-PrP in the bodily sample is then compared to a control... Agent: Tarolli, Sundheim, Covell & Tummino, LLP

20090246794 - Methods and kit for detecting breast cancer: The present inventions relates to kits and methods for diagnosing and monitoring breast cancer. An increase in the level or activity of proteins of the ubiquitin/proteasome pathway, and ancillary proteins thereof, as compared to normal control or benign tissue is indicative of breast cancer.... Agent: Licata & Tyrrell P.c.

20090246801 - Rapid test for glycated albumin in blood: The test is performed using a disposable strip or cassette that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and... Agent: Stetina Brunda Garred & Brucker

20090246802 - Annexin-based apoptosis markers: The present invention describes an annexin derivative and a method of using the annexin derivative as a biosensor for real-time visualization of phosphatidylserine exposure, apoptosis, live-cell imaging and monitoring of cell health.... Agent: Davis Wright Tremaine LLP/los Angeles

20090246805 - Method for classifying and counting basophils: A method for counting basophils which comprises: (1) mixing and reacting a blood sample with an anti-CD123 antibody labeled with a first fluorescent label and an anti-CD294 antibody labeled with a second fluorescent label to prepare a measurement sample, (2) introducing the measurement sample into a flow cell of a... Agent: Sughrue Mion, Pllc

20090246806 - Coccidioides antigen immunoassay: The present disclosure relates to methods for detecting a Coccidioides in a physiological specimen. Methods, materials and kits relating to the detection of Coccidioides antigen by improved EIA methods are described.... Agent: Brinks Hofer Gilson & Lione/ann Arbor

20090246803 - Nad biosynthesis systems: The present invention generally relates to a nicotinamide adenine dinucleotide (NAD) biosynthesis system and methods of screening for NAD biosynthesis effectors. Among the various aspects of the present invention is the provision of an in vitro-reconstituted mammalian NAD biosynthesis system that can be used for the high-throughput screening of chemical... Agent: Senniger Powers LLP

20090246804 - Immuno gold lateral flow assay: A chromatographic specific binding assay strip device, comprising: a non-permeable platform strip; a permeable membrane testing strip positioned on top of said non-permeable platform strip, with the testing strip comprising at least one capture reagent site containing a capture reagent for at least one specific analyte, a sample receiving pad... Agent: Jonathan E. Grant/grant Patent Services

20090246807 - Method for quantitative measurements of hdl-c and ldl-c: The present invention relates to a method for direct measurement of high-density lipoprotein cholesterol. (HDL-C) or low-density lipoprotein cholesterol (LDL-C) based on a modified chemical precipitation method, wherein the improvements were made by optimizing the concentrations and proportions of potassium polyvinyl sulfate (PVSK) and polyethylene glycol methyl ether (PEGME) in... Agent: Sofer & Haroun LLP.

20090246808 - Biosensor with improved analyte specificity: A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20090246809 - Method of supporting a diagnosis of a risk of cancer recurrence, and a device of supporting a diagnosis of a risk of cancer recurrence: A method of supporting a diagnosis of a risk of cancer recurrence is disclosed. The method provides a new determining value a recurrence risk score (RRS) which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The risk of cancer recurrence is judged by... Agent: Sughrue Mion, Pllc

20090246810 - Use of mrp 8/14 levels for discrimination of individuals at risk of acute coronary syndromes: The present invention relates to a method for determining the risk whether an individual showing at least one symptom of an evolving acute coronary syndrome (ACS) is suffering from an acute coronary syndrome comprising the steps of (a) measuring, preferably in vitro, the level of MRP 8/14, wherein (b) if... Agent: Roche Diagnostics Operations Inc.

20090246811 - Dry analytical element for lipase measurement: The present invention provides a method for producing a dry analytical element for measurement of pancreatic lipase contained in a body fluid which contains triglyceride of long chain alkyl fatty acid having 12 to 22 carbon atoms, monoglyceride lipase, and a glycerine measurement reagent, and comprises a water-impermeable support and... Agent: Birch Stewart Kolasch & Birch

20090246812 - Dry analytical element for lipase measurement: It is an object of the present invention to provide: a dry analytical element for analyzing pancreatic lipase wherein the triglyceride is not transcribed on the support to contaminate a transportation slip or other analytical elements and wherein an additive solution of the triglyceride neither reaggregates nor precipitate, so that... Agent: Birch Stewart Kolasch & Birch

20090246813 - Selective acceleration of fragmentation through joint application of enzymes and ultrasound: The present invention refers to an acceleration process for macromolecular fragmentation in liquid medium, in gel or in a solid support, by means of joint application of enzymes and ultrasounds, as well as isotopes. The macromolecules, in any of these liquids, are mixed with enzymes and inserted in a recipient... Agent: Sughrue Mion, Pllc

20090246815 - Protease detection material, set of protease detection materials, and method for measuring protease: The present invention provides a protease detection material having, on a support, at least a layer containing a dye precursor and a layer which contains a protease substrate and is disposed on the same side of the support as the layer containing the dye precursor and farther from the support... Agent: Birch Stewart Kolasch & Birch

20090246814 - Reagent for digestion of hemoglobin: The present invention relates to a reagent for digestion of hemoglobin comprising a buffer, pepsin and a 1,3-dialkyl-imidazolium salt. It also discloses to the use of this reagent in a method for digesting hemoglobin, in a method for detecting HbA1c, and to a sampling tube for collection of a whole... Agent: Roche Diagnostics Operations Inc.

20090246817 - Dry analytical element capable of reducing influence of hemolysis for body fluid component measurement: It is an object of the present invention to reduce influence of hemolysis in a dry analytical element used for measurement of components in a body fluid sample such as blood. The present invention provides a method for producing a dry analytical element for body fluid component measurement comprising at... Agent: Birch Stewart Kolasch & Birch

20090246816 - Methods and kits for selecting an analgesic regime: A method is provided for selecting an analgesic regime for treatment of a patient. In the method, a body fluid sample from the patient is assayed for the presence of a metabolite produced by metabolism of a prodrug. If the metabolite is present in the body fluid sample this indicates... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20090246818 - Compounds, methods, complexes, apparatuses and uses relating to stabile forms of nad/nadh: The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.... Agent: Roche Diagnostics Operations Inc.

20090246819 - Assay methods using chemiluminescent detection of peroxidase: Methods for generating chemiluminescence rapidly by reaction of at least one compound comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups with a peroxidase enzyme and a peroxide are disclosed. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase... Agent: Lumigen, Inc./beckman Coulter, Inc.

20090246820 - Compounds useful in cftr assays and methods therewith: The present invention relates to compounds useful in CFTR assays. The present invention also relates to compounds useful in monitoring CFTR activity in therapies for CFTR-mediated diseases. The present invention also provides an assay for use in measuring CFTR correction.... Agent: Vertex Pharmaceuticals Inc.

20090246821 - Peroxiredoxin drugs for treatment of hiv-1 infection and methods of use thereof: The invention includes compositions comprising substantially purified peroxiredoxin that are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies... Agent: Burns & Levinson, LLP

20090246822 - Composition for cell permeabilization comprising nog, hmp, rubidium chloride and/or lithium chloride for detecting living cells on a membrane: The present invention relates to a composition for the permeabilization of the walls of microorganisms comprising the combination of octyl-β-D-glucopyranoside (NOG), sodium polyphosphates (HMP), and a salt chosen from lithium chloride or rubidium chloride, and a method for the enumeration and identification of cells on a membrane using said composition.... Agent: Nields, Lemack & Frame, Llc

20090246823 - Evaluation methodology of the protection characteristics of personal protective equipments against biological agents: New testing methodology for the evaluation of the protection of the Personal Protective Equipments (PPE) for the respiratory tract against biological agents, characterized in that different machineries are used to reproduce the usage of the PPE, simulating a breathing through the Sheffield's head and self-respirator. The apparatus consists of: a)... Agent: Young & Thompson

20090246825 - Method for processing a tissue specimen in situ prior to histological examination: The present invention is directed to a method for processing a tissue specimen in situ prior to histological examination by providing a tissue specimen having a predetermined examination face, disposing the specimen on a tissue positioning member for removably maintaining the tissue specimen with the examination face in a desired... Agent: Thompson Coburn LLP

20090246824 - Methods for integrated tissue processing and staining: Methods that combine processing and staining of tissue samples such that the processed tissue is stained and ready for histological evaluation prior to embedding and sectioning, and separate staining of the sectioned tissue is not required. The method may be used with chemical and/or mechanical/thermal tissue penetrant enhancers in an... Agent: Thompson Hine L.l.p. Intellectual Property Group

20090246826 - Bi-directional selection markers with improved activity: The present invention discloses a polypeptide selected from the group consisting of: a polypeptide having an amino acid sequence according to SEQ ID NO 3, a polypeptide having an amino acid sequence according to SEQ ID NO 6, a polypeptide having an amino acid that is substantially homologous to the... Agent: Nixon & Vanderhye, Pc

20090246827 - Recombinant toxin fragments: A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the... Agent: Morris Manning Martin LLP

20090246828 - Arabinose isomerase expressed from corynebacterium genus and tagatose manufacturing method by using it: The present invention relates to a thermophilic arabinose isomerase and a method of manufacturing tagatose using the same, and more precisely, a gene encoding arabinose isomerase originating from the thermophile Thermotoga neapolitana DSM 5068, a recombinant expression vector containing the gene, a method of preparing a food grade thermophilic arabinose... Agent: Occhiuti Rohlicek & Tsao, LLP

20090246829 - Sequence analysis of the tetravalent rotavirus vaccine: Isolated nucleic acid molecules comprising a gene segment from a rhesus rotavirus (RRV) or from one of three rhesus:human reassortant viruses are disclosed, including isolated nucleic acid molecules having a sequence selected from the group consisting of: SEQ ID NO: 1-14, inclusive, and isolated nucleic acid molecules encoding a protein... Agent: Townsend And Townsend And Crew, LLP

20090246830 - Recombinant influenza viruses for vaccines and gene therapy: A method for producing influenza virus particles for preparation of a vaccine. The method comprises growing reassortant influenza viruses to produce virus particles and recovering the produced virus particles. The reassortant influenza viruses are produced in cultured cells in the absence of helper virus by introducing into the cultured cells... Agent: Sughrue Mion, Pllc

20090246831 - Methods for recombinant peptide production: The present invention provides improved methods for the production of recombinant peptides from bacterial cells.... Agent: John M. Polo Xoma (us) Llc

20090246832 - Production of polysialic acid containing glycoconjugates using a self-priming polysialyltransferase: The invention relates to a fusion protein comprising a bifunctional sialytransferase and a poly-sialytransferase and methods to use the fusion proteins for production of poly-sialylated end products, e.g. oligosaccharides and glycoproteins.... Agent: Townsend And Townsend And Crew, LLP

20090246833 - Small interfering rnas as non-specific drugs: The present invention is directed to a method of modulating (e.g., inducing, inhibiting) activation of a double stranded RNA (dsRNA) signaling pathway, such as the dsRNA signaling pathway that accompanies RNA interference (RNAi) of a target RNA sequence, in a cell, comprising introducing into the cell small interfering RNA (siRNA)... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20090246834 - Nano-pcr: methods and devices for nucleic acid amplification and detection: Methods, devices, and compositions are described that provide for amplification of nucleic acid sequences without reliance upon temperature cycling, thus freeing the methods from conventional benchtop thermal cycling devices. Denaturation of double stranded nucleic acids, primer annealing, and precision control over primer extension by polymerase can be accomplished by applying... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20090246835 - l-amino acid-producing bacterium and a method for producing an l-amino acid: An L-amino acid is produced by culturing a microorganism of the family Enterobacteriaceae which has the ability to produce an L-amino acid and which has been modified so as to increase the expression of the evgA gene, the gadE gene, and/or the ydeO gene. These genes encode a transcription factor... Agent: Cermak & Kenealy LLP Acs Llc

20090246836 - Pgro expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090246837 - Process for the preparation of optically active chiral amines: The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.... Agent: Harness, Dickey & Pierce, P.L.C

20090246838 - Process for the production of cadaverine: Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA... Agent: Connolly Bove Lodge & Hutz, LLP

20090246839 - Enzymatic modification of triglyceride fats: Process wherein the fatty acid residues on a glyceride moiety are randomised over the terminal and middle positions, wherein the process proceeds to a conversion degree on the terminal positions, Re, ranging from 0.3 to 0.95, and wherein a conversion degree on the middle position, Ra, ranges from 0.06 to... Agent: Unilever Patent Group

20090246840 - Process for producing isomer enriched conjugated linoleic acid compositions: A process for the preparation of a composition comprising the cis9, trans11 and trans10, cis12 isomers of conjugated linoleic acid (CLA) comprises: providing a mixture comprising cis9, trans11 and trans10, cis12 isomers of conjugated linoleic acid (CLA) in which one of the cis9, trans11 and trans10, cis12 isomers is present... Agent: Morgan Lewis & Bockius LLP

20090246841 - Methods and compositions for production of acetaldehyde: The present disclosure provides methods for producing acetaldehyde from renewable biological resources, for example, from a fermentable substrate, with the advantages of energy efficiency and ease of purification. Particular embodiments, feature the production of acetaldehyde from pyruvate, wherein the pyruvate is generated from various carbon sources (e.g., sugars) by pyruvate-producing... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090246842 - Engineered microorganisms for producing propanol: Methods and compositions for the production of bio-based material precursors are provided.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090246843 - Process for producing erythritol using moniliella tomentosa strains in the presence of neutral inorganic nitrates, such as potassium nitrate, ammonium nitrate or sodium nitrate, as nitrogen source: The present invention relates to the use of at least one inorganic nitrate in a fermentation process for producing erythritol using a yeast strain of the Moniliella species as an erythritol-producing microorganism characterized in that the at least one inorganic nitrate is simultaneously used as a main nitrogen source and... Agent: Paul And Paul

20090246845 - Glucoamylase and buttiauxiella phytase during saccharification: Described are compositions and methods relating to the use of a glucoamylase in combination with a phytase in starch processing to reduce the levels of phytic acid in end-products.... Agent: Danisco Us Inc. Genencor Division

20090246847 - Method for producing ethanol from steam exploded sweet potato by fermentation: A method for producing ethanol from steam-exploded sweet potato by fermentation includes subjecting sweet potato to a steam explosion treatment, subjecting the sweet potato after the steam explosion to saccharification and fermentation, and collecting ethanol produced by the fermentation. The sweet potato can optionally be subjected to a pre-treatment utilizing... Agent: Knobbe Martens Olson & Bear LLP

20090246844 - Methods for the production of ethanol: Embodiments of the present invention include methods for the production of ethanol, by a consolidated bioprocessing approach for the conversion of cellulosic material. According to some embodiments, recombinant microbial host cells are provided, preferably S. cerevisiae, that are capable of converting cellulosic material to ethanol and include cellulase genes. According... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20090246846 - Zymomonas with improved xylose utilization: Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090246848 - Process and apparatus for dewatering cellulosic fermentation products: A liquid mixture of water and a small percentage of an alcohol, for example a cellulosic fermentation broth, is converted into a mixture of vapours. The vapour mixture includes an increased percentage of alcohol vapour relative to the liquid mixture but is mostly water vapour. Water vapour is removed from... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20090246849 - Biogenic methane production enhancement systems: Systems for enhanced in-situ or perhaps even ex-situ biogenic methane production from hydrocarbon-bearing formations (1) including coal seam, oil shale, coal, coal derivates and the like are presented in embodiments such as but not limited to: increasing and perhaps even selection of microbial populations (2), amending CBM water and other... Agent: Santangelo Law Offices, P.c.

20090246850 - Method for biocatalysis using filamentous fungi: A method is disclosed in which filamentous fungi are macerated and encapsulated in an inert matrix to form beads, which can be used to promote reactions carried out by the fungi. The beads are useful, e.g., for producing compounds and compound libraries.... Agent: Wilmerhale/boston

20090246851 - Method for production of enzyme: The present invention provides a process for producing an enzyme, which includes recovering an enzyme by microfiltering an enzyme-containing solution, having a cell density of 1% (v/v) or less and an enzyme concentration of 1% (w/v) or more in terms of the amount of proteins, with a cationic surfactant added... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20090246852 - Therapeutic use of anti-cs1 antibodies: The present invention is directed to antagonists of CS1 that bind to and neutralize at least one biological activity of CS1. The invention also includes a pharmaceutical composition comprising such antibodies or antigen-binding fragments thereof. The present invention also provides for a method of preventing or treating disease states, including... Agent: Dechert LLP

20090246853 - Directed evolution method: We describe a method of selecting an enzyme having replicase activity, the method comprising the steps of: (a) providing a pool of nucleic acids comprising members each encoding a replicase or a variant of the replicase; (b) subdividing the pool of nucleic acids into compartments, such that each compartment comprises... Agent: Edwards Angell Palmer & Dodge LLP

20090246855 - Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences: The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a... Agent: Jones Day

20090246854 - Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same: The invention relates to a scleroprotein of an adeno-associated virus which contains at least one mutation. Said mutation causes the chromatographic properties to be modified. The invention also relates to the production of said scleroprotein and the use thereof.... Agent: Clark & Elbing LLP

20090246857 - Stable recombinant yeasts for fermenting xylose to ethanol: Described are recombinant yeast which ferment xylose to ethanol and which maintain their ability to do so when cultured for numerous generations in non-selective media. The preferred yeast contain multiple copies of integrated genes encoding xylose reductase, xylitol dehydrogenase, and xylulokinase fused to promoters which are non-glucose inhibited and which... Agent: Mueting, Raasch & Gebhardt, P.a.

20090246856 - Trichoderma reesei phytase enzymes, nucleic acids encoding such phytase enzymes, vectors and host cells incorporating same and methods of making and using same: A novel DNA is provided which encodes an enzyme having phytase activity isolated from Trichoderma. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the transformed DNA... Agent: Danisco Us Inc. Attention: Legal Department

20090246858 - Drain treatment system: A drain treatment system includes a puck containment basket having an open top, sides, a bottom attached to the sides, and a rim attached to the sides at the open top. The sides and bottom of the puck containment basket have openings to permit liquid flow while restricting passage of... Agent: Fulbright And Jaworski LLP

20090246859 - Methods and compositions for purification of nucleic acid from a host cell: Methods and compositions are provided for gently lysing and solubilizing cells. Methods and compositions are further provided for quickly purifying high quality low molecular weight nucleic acid from host cells. Target cells are treated with a pre-chilled lysis solution having a zwitterionic detergent, for example n-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate, and a brief room-temperature... Agent: King Spalding LLP

20090246860 - Point source diffusion cell activity assay apparatus: Apparatuses and methods for determining whether a test compound solution induces cell activity, an embodiment of the method of the present invention comprising placing a test compound solution in contact with a cell suspension media containing cells, diffusing the test compound solution into the cell suspension from a point source,... Agent: Paul, Hastings, Janofsky & Walker LLP

20090246861 - Chromatographic test device: A chromatographic test device comprising, in the order of passage of a sample containing blood cell components and liquid components, a label holding member provided with a labeling substance capable of binding specifically to an analyte contained in the liquid components, a blood cell separation member for separating predetermined blood... Agent: Sughrue Mion, Pllc

20090246862 - Bioluminogenic assay system for measuring beta-lactamase activity: A bioluminogenic assay system including: providing a bioluminogenic substrate incorporating a beta-lactam antibiotic, a bioluminescence initiating compound, and a chemical linkage joining the beta-lactam antibiotic to the bioluminescence initiating compound; exposing the bioluminogenic substrate to a beta-lactamase enzyme that catalyzes the release of the bioluminescence initiating compound from the bioluminogenic... Agent: Law Offices Of Mikio Ishimaru

20090246863 - Apparatus for cultivating oil-rich microalgae: An apparatus for cultivating oil-rich microalgae includes a tank having a cultivation medium held therein for cultivating the oil-rich microalgae, the tank being provided at predetermined positions with at least one feeding pipe for feeding carbon dioxide and other nutrients to the tank and at least one drain pipe for... Agent: Wpat, Pc Intellectual Property Attorneys

20090246864 - Cell culture device and methods for manufacturing and using the cell culture device: A cell culture device, a method for manufacturing the cell culture device using an In Mold Labeling (IML) technique, and a method for using the cell culture device are all described herein. The cell culture device is an In Line Molded frame which has a cell growth film permanently bonded... Agent: Corning Incorporated

20090246865 - Porous film: A porous film is used as a cell culture substrate that is a scaffold for a spheroid. The porous film has a plurality of pores whose diameters gradually increase in a direction A. The diameters of the pores gradually increase from a first area P1 to a third area P3... Agent: Sughrue Mion, Pllc

20090246866 - Ready-to-use whole blood collection vessel: The present invention relates to a sampling tube for collecting and processing a whole blood sample. The sampling tube contains a reagent for differential hemolysis of whole blood, wherein said reagent for differential hemolysis comprises a chemical for differential hemolysis and an anti-coagulant, and wherein said sampling tube is a... Agent: Roche Diagnostics Operations Inc.

20090246867 - Glial mitogenic factors, their preparation and use: Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors.... Agent: Klauber & Jackson

20090246868 - Serum-free vero cell banking process: A serum-free Vero cell banking process provides a standardized and consistent way to generate reliable and stable cell banks for viral vaccine production. The substitution of animal-derived substances with plant-derived substances in the growth and freezing media increases the viability of the cells upon thawing and reduces their recovery time,... Agent: Wyeth Patent Law Group

20090246869 - Differentiation of primate pluripotent stem cells to hematopoietic lineage cells: The invention provides methods of differentiating primate pluripotent stem cells into cells of hematopoietic lineage. The invention further provides hematopoietic lineage cells differentiated from primate pluripotent stem cells, as well as methods of using the same and kits comprising the same.... Agent: Geron Corporation Attn. David J. Earp

20090246871 - Container for germ layer formation and method of forming germ layer: The invention relates to a vessel for embryoid formation used for forming embryoid bodies from ES cells easily without complicated technique, and to a method for forming embryoid bodies easily and efficiently using the vessel. The method includes the steps of (A) providing a vessel for embryoid formation having a... Agent: Sughrue Mion, Pllc

20090246870 - De-differentiation of astrocytes into neural stem cell using nanog: Disclosed are a composition and a method for inducing the de-differentiation of astrocytes into neural stem cells using Nanog. The de-differentiated neural stem cells have the ability to differentiate into astrocytes, neurons, or oligodendrocytes.... Agent: Bozicevic, Field & Francis LLP

20090246873 - Scaffold for tissue engineering and production method thereof: To provide a scaffold for tissue engineering which consists of a bioabsorbable polymer material to be absorbed in a biotissue, and holds strength of the whole scaffold while having a porosity proper for culturing cells inside thereof as well, a method for producing the scaffold for tissue engineering includes steps... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20090246872 - Structure for cell culture, cell culture vessel, structure with spheroid, vessel with spheroid, and manufacturing methods thereof: By using a microfabrication technique such as nanoimprinting, a structure for cell culture comprising: a concavo-convex structure having a plurality of successive unit structures each formed in a polygonal shape in a planar direction and having a minimum internal diameter of less than or equal to 3 μm, wherein a... Agent: Factor & Lake, Ltd

20090246874 - Method and device for culturing neural cells: A method and device are provided for culturing neural cells within a microfluidic device. A layer of predetermined material is deposited on a substrate and a cartridge is positioned on the substrate. The cartridge defines a first channel communicating with the predetermined material; a chamber communicating with the first channel... Agent: Wisconsin Alumni Research Foundation

20090246875 - Efficient method for nuclear reprogramming: This relates to a method of preparing induced pluripotent stem cells, comprising a nuclear reprogramming step with a nuclear reprogramming factor in the presence of miRNA, wherein said miRNA has a property of providing a higher nuclear reprogramming efficiency in the presence of said miRNA than in the absence thereof.... Agent: Greenblum & Bernstein, P.L.C

20090246876 - High expression zymomonas promoters: Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center