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Chemistry: molecular biology and microbiology September class, title,number 09/09

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
09/24/2009 > patent applications in patent subcategories. class, title,number

20090239206 - Solution for preserving liver: The present invention provides a liver preservation solution containing trehalose and dibutyryl-cAMP. The content of nitroglycerin in the preservation solution is preferably lower than 0.44 mM. In the liver preservation solution of the present invention, since the toxicity due to nitroglycerin, which is observed during liver preservation, has been improved,... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090239207 - Method of assessing the viability of thawed cells: The invention relates to a method of assessing the viability of a thawed cell wherein the cell is a gamete, an embryo, a karyoplast, a putative stem cell population, a stem cell precursor population or a stem cell population. The method includes incubating the thawed cell in a culture medium... Agent: Myers Bigel Sibley & Sajovec

20090239208 - Red blood cell storage medium for extended storage: Synthetic aqueous storage solutions are disclosed for use in the processing and the storing of red blood cells prepared from whole blood including cells derived from whole blood held for an extended period at room temperature.... Agent: Cook Alex Ltd

20090239209 - Combined installation for the production of biogas and compost, and method of switching a fermenter in a like installation between biogas production and composting: A combined installation is disclosed for the production of biogas and compost, including a dry fermentation fermenter for producing biogas in a batch mode, a biogas outlet, a purging gas inlet, a biogas line connected to the biogas outlet, a waste gas line, a waste gas chimney connected to the... Agent: Morrison & Foerster, LLP

20090239210 - Proteins recruited by virus during infection of plants and method for their isolation and identification: The invention relates to a method for isolating and identifying proteins from protein-virus complexes and comprises: —the gel exclusion chromatography of virus-protein complexes extracted from infected plants or such as obtained by adding a purified virus to soluble proteins extracted from non infected plants, —SDS-PAGE of the proteins-analysis by NanoLC-MS/MS... Agent: Nixon & Vanderhye, PC

20090239235 - facs- and reporter protein-based system for high throughput development of therapeutic proteins: Methods are disclosed to identify, select and produce a clonal population of recombinant eukaryotic host cells that stably and highly express a polypeptide of interest. Also disclosed herein are products produced by the disclosed methods and assemblies of components useful to conduct the methods.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090239228 - Chimeric promoter molecules for gene expression in prokaryotes: The present invention provides regulatory polynucleotide molecules isolated from a 16S rDNA for enhanced expression of heterologous genes. The invention further discloses compositions, polynucleotide constructs, transformed host cells containing the regulatory polynucleotide sequences, and methods for preparing and using the same.... Agent: Sonnenschein Nath & Rosenthal LLP

20090239215 - Clonable tag for purification and electron microscopy labeling: The disclosure provides compositions and methods for heavy atom labeling of a target protein using a clonable tag. The clonable tag comprises a metal binding protein, or fragment thereof, such as metallothionein, which may be fused to a target protein of interest. The tag permits the target protein to be... Agent: Ropes & Gray LLP

20090239222 - Composition for nucleic-acid transfection: The invention provides a composition for transfecting a nucleic acid into a cell, including a compound represented by the following formula (I) (wherein each of R1 and R2, which are identical to or different from each other, represents a saturated or unsaturated hydrocarbon group; R3 represents a C1-6 alkyl group... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090239220 - Dlc-1 gene deleted in cancers: A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to... Agent: Klarquist Sparkman, LLP

20090239229 - Dna repair proteins associated with triple negative breast cancers and methods of use thereof: The present invention provides methods of detecting triple negative breast cancer recurrence using biomarkers.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090239236 - Gene detection assay for improving the likelihood of an effective response to an egfr antagonist cancer therapy: The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing EGFR, as determined by a gene amplification assay, with an EGFR antagonist. Such method comprises administering a cancer-treating dose of the EGFR antagonist, preferably in addition to chemotherapeutic agents, to a subject... Agent: Genentech, Inc.

20090239234 - Identification and/or quantification method of nucleotide sequence(s) elements specific of genetically modified plants on arrays: A method for identifying a genetically modified plant by identification and/or quantification of different, multiple nucleotide sequence elements corresponding to at least a portion of an exogenous nucleotide sequence integrated into the genome of the genetically modified plant. The method involves amplifying a nucleic acid sequence element into target nucleic... Agent: Knobbe Martens Olson & Bear LLP

20090239213 - Identifying a target polynucleotide: A method for identifying the presence of a single stranded target polynucleotide in a sample comprising the steps of (i) contacting the target polynucleotide, under hybridising conditions, with at least first and second polynucleotide probes, each of which comprise a first region complementary to adjacent non-overlappïng regions of the target... Agent: Marshall, Gerstein & Borun LLP

20090239230 - Lung cancer diagnosis based on expression levels of gimap genes: Diagnosis of lung cancer based on the expression level(s) of one or more GTPase of Immunity-Associated Proteins (GIMAP) and method for identifying anti-lung cancer drug candidates based on their up-regulation of GIMAP activity.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090239226 - Markers for breast cancer: Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.... Agent: Goodwin Procter LLP Attn: Patent Administrator

20090239211 - Method for enrichment involving elimination by mismatch hybridisation: The present invention relates to a method for selecting a molecule from a library of such molecules associated with identifier oligonucleotides, said molecule having affinity towards a target. The method involves contacting library with a target to allow for an interaction between the molecules and the target and partitioning a... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090239218 - Method for the diagnosis and treatment of cardiovascular diseases: The present invention refers to a method for the in vitro or in vivo diagnosis of cardiovascular diseases, in particular high blood pressure, stenosis, vessel occlusion and/or other thrombotic events, wherein the nucleotide at position 950 of a nucleic acid coding for the human ARK2 protein or the amino acid... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20090239237 - Method for the identification of a risk for a thrombogenic disorder by determining the tafl-lle347 polymorphism: The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20090239227 - Method of diagnosing risk of myocardial infarction: It is intended to provide a means of diagnosing myocardial infarction which shows a high accuracy and a high predictability. The risk of myocardial infarction is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 10 gene polymorphisms or 5 gene... Agent: Edwards Angell Palmer & Dodge LLP

20090239224 - Methods for identifying bioagents: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.... Agent: Casimir Jones, S.c.

20090239232 - Methods of rna amplification in the presence of dna: The invention provides methods for amplification of RNA. The methods are particularly suitable for specifically amplifying RNA in the presence of DNA. The methods involve producing a marked first primer extension product from a target RNA in the presence of a DNA-dependent DNA polymerase inhibitor, which prevents replication of DNA... Agent: Wilson Sonsini Goodrich & Rosati

20090239216 - Novel tannase gene and protein thereof: e

20090239225 - Prediction and diagnosis of canine degenerative myelopathy: The present invention provides for methods of identifying a dog carrying a major genetic risk factor in the SOD1 gene for degenerative myelopathy, a potential model for human amyeotrophic lateral sclerosis. Also provided a methods of early diagnosis, treatment and breeding based on the presence or absence of the marker.... Agent: Fulbright & Jaworski L.L.P.

20090239223 - Prediction of breast cancer response to taxane-based chemotherapy: The invention relates to methods and kits for the prediction of a likely outcome of chemotherapy in a cancer patient. More specifically, the invention relates to the prediction of tumour response to chemotherapy based on measurements of expression levels of a small set of marker genes. The set of marker... Agent: Siemens Corporation Intellectual Property Department

20090239214 - Prognosis of breast cancer patients: The present invention relates to sets of genetic markers whose expression is correlated with prognosis of breast cancer in individuals having breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate individuals having a good prognosis, e.g., no reoccurrence or metastasis within five... Agent: Jones Day

20090239221 - Recurrent gene fusions in prostate cancer: Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.... Agent: Casimir Jones, S.c.

20090239231 - Rna from cytology samples to diagnose disease: The invention relates to methods and kits for detecting the likelihood that a subject has cancer, e.g., squamous cell carcinoma, by assaying the expression levels of tumor associated genes. More specifically, the expression levels of nucleic acids or proteins can be assayed in the tumor associated genes, e.g., beta-2 microgobulin... Agent: Nutter Mcclennen & Fish LLP

20090239212 - Screening for the genetic defect causing tibial hemimelia in bovines: The invention provides methods, materials and kits for analyzing DNA samples from bovine to determine whether the animal is a recessive carrier of a genetic mutation that is associated with tibial hemimelia. DNA-containing samples are analyzed by genetic testing to determine whether or not a deletion mutation is present in... Agent: Greenlee Winner And Sullivan P C

20090239233 - Single-tube, ready-to-use assay kits, and methods using same: An assay kit is provided that includes assay reagents stored in a single-tube container, and a data storage medium containing information about the contents of the container. Methods are provided for using the data provided with the kit to direct instruments and/or processes, for example, to control an instrument to... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090239217 - Stem-like cells in bone sarcomas: Isolation and purification of stem cells from within a bulk sarcoma tumor. These cells express the marker genes of pluripotent embryonic stem cells, Stat 3, Oct 3/4, and Nanog. A subset of these cells show the surface marker of mesenchymal stem cells Stro-1, as well as express attributes of mesodermal,... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20090239219 - Telomerase expression repressor proteins and methods of using the same: Telomerase repressor proteins and nucleic acid compositions encoding the same are provided. The subject repressor proteins bind to a repressor site in the TERT minimal promoter, e.g., a Site C site, and thereby inhibit TERT expression. Also provided are methods of modulating, e.g., inhibiting or enhancing, TERT expression. The subject... Agent: Bozicevic, Field & Francis LLP

20090239239 - Eukaryotic amadoriase having excellent thermal stability, gene and recombinant dna for the eukaryotic amadoriase, and process for production of eukaryotic amadoriase having excellent thermal stability: Disclosed are: a eukaryotic amadoriase which is prepared by introducing a mutation into DNA encoding a eukaryotic amadoriase derived from a microorganism belonging to the genus Coniochaeta or Eupenicillium so as to introduce a substitution into a specific amino acid residue in the eukaryotic amadoriase, thereby overcoming the defect associated... Agent: Morris Manning Martin LLP

20090239238 - Methods for measuring pro-inflammatory substance levels in dialysis solutions and dialysis components: Methods of measuring levels of pro-inflammatory substances in dialysis solutions or specific dialysis components used to manufacture dialysis solutions are provided. In a general embodiment, the method comprises determining an IL-6 response versus a pro-inflammatory substance concentration of a reference standard containing a pro-inflammatory substance and establishing a dose-response curve... Agent: K&l Gates LLP

20090239241 - Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids: The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's... Agent: Morrison & Foerster LLP

20090239240 - Mutant forms of fas ligand and uses thereof: The invention provides for DNA encoding Fas ligand muteins and chimeras and the proteins encoded thereby. The invention further includes the use of DNA and vectors to produce transformed cells expressing the mutant or chimeric Fas ligand. When the Fas ligand of the invention is a non cleavable form, the... Agent: Novartis Vaccines And Diagnostics Inc.

20090239246 - Biomarkers: The invention provides methods for predicting, diagnosing or monitoring acute cardiac disorders, cardiac transplant rejection, or distinguishing acute cardiac disorders from pulmonary disorders, by measuring BNP signal peptide levels in a sample taken from a subject shortly after onset of, or presentation with the disorder or transplant rejection.... Agent: Duane Morris LLP - San Diego

20090239247 - Mn and hypoxia: The MN/CA IX protein is identified herein as a hypoxia marker. The MN/CA9 gene promoter is characterized, and the location of the HIF-1 binding site within the MN/CA9 promoter is identified. Further, the hypoxia inducibility of the MN/CA9 gene and the uses of such inducibility are disclosed. In one aspect,... Agent: Leona L. Lauder

20090239242 - Method for the early identification and prediction of kidney injury: A method for the early identification and prediction of elevated blood creatinine levels resulting from a reduction in kidney function in a subject, comprises contacting a urine sample from the subject with a capture molecule for a biomarker specific for the distal region of the renal tubule and which biomarker... Agent: Birch Stewart Kolasch & Birch

20090239243 - Method of identifying compounds useful to treat neuronal degenerative diseases: Methods of identifying agents that inhibit ROS by altering the binding of a GTPase such as Rac to SOD, agents identified by the method, and methods of using compounds that inhibit ROS to inhibit or treat neuronal degenerative diseases, are provided.... Agent: Schwegman, Lundberg & Woessner, P.A.

20090239244 - Modulators of protein phosphatase 2a and pp2a methyl esterase: The disclosure relates to modulation of protein phosphorylation, including information derived from the structures and activities of the proteins designated protein phosphatase 2A (PP2A) and PP2A methyl esterase. The disclosure contained herein provides compounds and methods for identification of compounds that antagonize the function of PME, and thus reduce levels... Agent: Pepper Hamilton LLP

20090239245 - Method for diagnosis and prognosis of epithelial cancers: The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to... Agent: Wolf Greenfield & Sacks, P.C.

20090239248 - Rapid and sensitive detection of bacteria in blood products, urine, and other fluids: The invention provides methods of detecting bacteria in fluids, including blood, platelets and other blood products for transfusion, and urine. The methods are based on lysing the bacteria to release ATP and detecting the ATP. Eukaryotic cell contamination is a problem to be overcome, because eukaryotic cell contain large amounts... Agent: Hugh Mctavish Mctavish Patent Firm

20090239254 - Functional pigmented skin equivalent: An in vitro skin equivalent includes at least one epidermis equivalent and at least one dermis equivalent, and further includes melanocytes constitutively producing melanin and fibroblasts.... Agent: Buchanan, Ingersoll & Rooney PC

20090239251 - Method for detecting nanoparticles and the use thereof: The invention relates to a method for detecting and/or qualifying nanoparticles whose mean size is less than 60 nm, which exhibit a plasmon resonance and are located on the top surface of a flat solid support. A device for carrying out the inventive method and the use thereof are also... Agent: Harness, Dickey & Pierce, P.L.C

20090239250 - Method for the analysis of cells: The present invention provides an improved method of analysing and obtaining reliable data about the plasma membrane of single cells, using a microfluidic cell analyser. The microfluidic cell analyser of the invention comprises a single cell trap, a manipulator arranged to manipulate the outer surface of a cell in the... Agent: Warner Norcross & Judd LLP

20090239253 - Methods of using quantitative lipid metabolome data: Described herein in various embodiments are methods for using quantitative and/or comparative lipid metabolite data, particularly for identifying and interpreting individual metabolomic profiles as indicative of metabolic status. The provided methods, for instance, allow analysis of the likelihood or progression of weight gain or weight loss, growth or wasting, obesity,... Agent: Marshall, Gerstein & Borun LLP (tethys) 233 S. Wacker Drive

20090239249 - Novel thermostable gluconate dehydratase and use thereof: The present invention relates to a novel thermostable gluconate dehydratase from the thermoacidophilic archaeon Sulfolobus solfataricus, a coding sequence, and an expression system. The gluconate dehydratase has a molecular weight of about 320,000 to 380,000 daltons as the native protein, and about 40,000 to 50,000 daltons as the monomer protein,... Agent: Jhk Law

20090239255 - Odontogenic ameloblast-associated protein as a tumor biomarker: Odontogenic ameloblast-associated (ODAM) protein may be used as an effective biomarker in humans for various cancers, especially those of epithelial origin, such as breast, lung, and stomach. The ODAM protein may be detected in cancerous cells. Additionally, the blood of patients with such cancers contains high titers of anti-ODAM antibodies.... Agent: Howard Eisenberg, Esq.

20090239252 - Rapid detection of volatile organic compounds for identification of bacteria in a sample: In various embodiments, the invention relates to a method for identifying the presence of particular bacteria in a sample. The method includes collecting a sample that includes or has been exposed to the particular bacteria and detecting, in the sample, at least one volatile organic compound indicative of the presence... Agent: Goodwin Procter LLP Patent Administrator

20090239256 - Detection of micro-organisms: The present invention relates to a method of detecting the presence of a viable micro-organism of interest in a sample containing a contaminating micro-organism.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20090239257 - Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching: A method for analyzing a blood sample is provided that includes the steps of: a) providing a blood sample having one or more first constituents and one or more second constituents, which second constituents are different from the first constituents; b) depositing the sample into an analysis chamber adapted to... Agent: O''shea Getz P.C.

20090239258 - Anti-il-6 antibody nucleic acid molecules and methods: Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.... Agent: Philip S. Johnson Johnson & Johnson

20090239260 - Fungal transcriptional activator useful in methods for producing polypeptides: The present disclosure relates to isolated nucleic acid sequences encoding polypeptides having transcriptional activation activity and to the polypeptides. The disclosure also relates to nucleic acid constructs, vectors and host cells including the nucleic acid sequences. The invention further relates to host cells useful for the production of polypeptides in... Agent: Novozymes North America, Inc.

20090239259 - Mammalian expression vectors and uses thereof: The present invention features nucleic acids for recombinant protein expression in mammalian cell culture. The episomal vectors of the invention promote high protein production in mammalian cells expressing the SV40 T Ag or Epstein-Barr virus nuclear antigen (e.g., COS7 or HEK293-6E cells). The methods and systems are useful, for example,... Agent: Lahive & Cockfield, LLP/abbott Floor 30, Suite 3000

20090239261 - Assembly of wild-type and chimeric influenza virus-like particles (vlps): Influenza virus-like particles (VLPs) comprising the structural proteins HA, NA, M1 and M2 are described. VLPs are also generated containing M1 alone, as are VLPs with M1 and any one or two of HA, NA and M2. VLPs with HA from one influenza subtype and NA from a different influenza... Agent: Wyeth Patent Law Group

20090239262 - Affinity polypeptide for purification of recombinant proteins: The present disclosure provides an affinity polypeptide for the purification of a recombinant biologically active protein or polypeptide. Further, the present disclosure provides a fusion recombinant protein or polypeptide wherein the fusion recombinant protein comprises of at least two components, a biologically active polypeptide or protein or protein of interest... Agent: Pharmaceutical Patent Attorneys, LLC

20090239263 - Expression control using antibody expression optimisation sequences: The present invention provides a dicistronic message for producing an antibody molecule, in which the upstream cistron contains DNA coding for the light chain of the antibody and the downstream cistron contains DNA coding for the corresponding heavy chain, characterised in that the dicistronic message comprises a sequence selected from... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090239264 - Immunization with bacterial ghost-based vaccines: Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating the cell-wall material with a solution capable of removing a cell-wall component such as a... Agent: Traskbritt, P.C.

20090239265 - Virus like particles: An isolated polynucleotides comprising a HBsAg-S coding sequence that is adapted to receive an insert coding sequence, within a part of the HBsAg-S coding sequence that encodes an exposed site within the external loop of HBsAgS, and still encode a HBsAg-S that is able to assemble into a VLP. Proteins... Agent: Stites & Harbison PLLC

20090239266 - Method for producing a non-aromatic l-amino acid using a bacterium of the enterobacteriaceae family having expression of the csra gene attenuated: The present invention provides a method for producing a non-aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the csrA gene.... Agent: Cermak & Kenealy LLP Acs LLC

20090239267 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the cpxr gene: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the cpxR gene.... Agent: Cermak & Kenealy LLP Acs LLC

20090239268 - method for producing an l-amino acid: The present invention provides a method for producing an L-amino acid by fermentation by culturing a microorganism having an L-amino acid-producing ability in a liquid medium to precipitate the L-amino acid, wherein a polymer such as a water-soluble cellulose derivative, a water-soluble polyvinyl compound, a polar organic solvent-soluble polyvinyl compound,... Agent: Cermak & Kenealy LLP Acs LLC

20090239269 - Method for production of l-amino acid: A bacterium which belongs to the Enterobacteriaceae family and has an ability to produce an L-amino acid such as L-lysine, L-threonine and L-tryptophan and is modified to enhance glutamic acid decarboxylase activity is cultured in a medium to produce and accumulate the L-amino acid in the medium or cells of... Agent: Cermak & Kenealy LLP Acs LLC

20090239270 - Compositions and methods for producing fermentation products and residuals: The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the... Agent: Wilson Sonsini Goodrich & Rosati

20090239271 - Fermentation broth extraction of k-252a: Methods for separating K-252a from the cell mass of its parent fermentation broth are disclosed.... Agent: Paul D. Yasger Abbott Laboratories

20090239272 - Production of flavonoids by recombinant microorganisms: Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phenylpropanoids to various flavonoids. The method comprises the steps of introducing the set... Agent: Hodgson Russ LLP The Guaranty Building

20090239273 - Novel high-activity modified s-hydroxynitrile lyase: This invention relates to a novel high-activity modified S-hydroxynitrile lyase (SHNL). More particularly, this invention relates to novel high-activity modified SHNL that is obtained by substituting amino acids at given sites (14, 44, 66, 94, 103, 118, 122, 125, 127, 129, 147, 148, 152, 212, and 216) or inserting amino... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090239274 - Yeast and method of producing l-lactic acid: i

20090239275 - Fermentive production of four carbon alcohols: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090239276 - Genetically modified yeast strain: A polyploid transformed yeast cell comprising a deleted or disrupted GDH1 gene encoding an NADPH-dependent glutamate dehydrogenase, said polyploid yeast cell showing increased production of ethanol and reduced production of glycerol when compared with a control polyploid yeast cell.... Agent: Borden Ladner Gervais LLP Anne Kinsman

20090239277 - Thermophillic organisms for conversion of lignocellulosic biomass to ethanol: Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of Thermoanaerobacterium saccharolyticum with acetate kinase and phosphotransacetylase expression eliminated are disclosed herein. Further, strain ALK1 has been engineered by site directed homologous recombination to knockout both acetic acid and lactic acid production. Continuous culture... Agent: Lathrop & Gage LLP

20090239278 - Method for producing bioethanol from a lignocellulosicbiomass and recycled paper sludge: A method producing ethanol by combining an plant fiber material containing calcium carbonate with at least one lignocellulosic agricultural residue into a mixture. The plant fiber material can be a paper sludge. The mixture is then hydrolyzed and the resultant hydrolysate is then fermented into ethanol.... Agent: Blank Rome LLP

20090239279 - Integrated biofuel production system: According to an embodiment, a biomass conversion subsystem produces methane and/or alcohol and residual biomass. A pyrolysis or a gasification subsystem is used to produce thermal energy and/or process gasses. The thermal energy may be stored thermal energy in the form of a pyrolysis oil. A fuel conversion subsystem produces... Agent: Baker Botts L.L.P.

20090239280 - Method for producing metal nanoparticles: This invention provides a method for producing a composition comprising colloidal nanoparticles of metals including silver, gold, zinc, mercury, copper, palladium, platinum, or bismuth, by contacting a metal or metal compound with bacteria. An embodiment of the method comprises a step of incubating probiotic bacteria with an aqueous solution comprising... Agent: Woodcock Washburn LLP

20090239281 - Moving a small object in a direction: For directional motion of a small object, a combination of at least two different properties is imparted to the object. At least one of the properties being responsive to an external influence to produce a force or torque acting on the object. At least another of the properties is responsive... Agent: Fish & Richardson PC

20090239282 - Method of storing and/or transporting in vitro cell cultures: The invention relates to a method of storing and/or transporting in vitro two-dimensional cell cultures. The inventive method comprises the following steps consisting in: a) coating a cell culture that is immobilised on an asymmetric support with a gelatine solution in culture medium at a concentration of between 1 and... Agent: Intellectual Property / Technology Law

20090239283 - Pyrophosphorolysis activated polymerization (pap): A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3′-deoxynucleotide at its 3′ terminus. PAP can be applied for exponential amplification or for linear... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090239284 - Alkaline bacillus amylase: This invention relates to an amylase derived from Bacillus horikoshii. The amylase has a preference for soluble substrates, shows substantial exo-amylase activity and has a pH optimum of about 9.8.... Agent: Novozymes North America, Inc.

20090239286 - Production of poxviruses with adherent or non adherent avian cell lines: The present invention relates to a method for replicating poxviruses such as vaccinia virus comprising the steps of inoculating avian embryonic stem cells with viral particles and culturing said cells in a basal medium until cells lysis occurs and newly produced viral particles are released in said medium.... Agent: Buchanan, Ingersoll & Rooney PC

20090239287 - Production of vaccines: Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removing the virus-containing... Agent: Traskbritt, P.C.

20090239285 - Tandem reapeat dna constructs producing proteins that attack plant pathogenic viruses, fungi, and bacteria by disrupting transcription factors essential for replication thereof in plants: or a pharmaceutical salt. The invention inactivates viruses by attacking the zinc finger domain in plants through Picolinic Acid (PA) and then ejecting the Zn2+ from the zinc finger proteins (ZFPs). The PA and derivatives control viruses containing essential ZFPs. A Tandem Repeated Sequence (TRS) technology, denoted the Cassette TRS... Agent: Charles C. Mccloskey

20090239288 - Integrated membrane separation - bioreactor for selective removal of organic products and by-products: A system for selective removal of metabolites from an aqueous broth including a bioreactor vessel containing at least one live culture producing at least one metabolite disposed within an aqueous broth, and a membrane module having a mixed matrix membrane suitable for selective removal of the at least one metabolite... Agent: Mark E. Fejer Gas Technology Institute

20090239289 - Drain foam composition and method of using the same: A foamable aqueous cleaning composition for treating surfaces to dissolve grease and organic waste materials thereon. The foamable aqueous cleaning composition comprises a) about 40 to about 60 percent by weight water; b) about 40 to about 60 percent by weight of a bioremediation agent capable of breaking down organic... Agent: Arthur G. Schaier Carmody & Torrance LLP

20090239290 - Single-tube, ready-to-use assay kits, and methods using same: An assay kit is provided that includes assay reagents stored in a single-tube container, and a data storage medium containing information about the contents of the container. Methods are provided for using the data provided with the kit to direct instruments and/or processes, for example, to control an instrument to... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090239291 - Culture vessel allowing large in situ scale up: The present invention, in one aspect, provides a culture vessel which includes a body having at least a first edge at least partially perimetrically bounding the body, and at least a first seal extending from the first edge. The first seal is breachable and fluid-tight, and disposed obliquely to the... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090239292 - Microfabricated apparatus for cell based assays: Apparatus and methods are provided for performing cell growth and cell based assays in a liquid medium. The apparatus comprises a base plate supporting a plurality of micro-channel elements, each micro-channel element comprising a cell growth chamber, an inlet channel and an outlet channel, a cover plate positioned over the... Agent: Fulbright & Jaworski, LLP

20090239293 - Grooved high density plate: A microplate having a main body portion. The main body portion having a first surface and an opposing second surface, and a groove disposed about the first surface of the main body portion. The groove separates the main body portion into an inboard section and an outboard section. A plurality... Agent: Life Technologies Corporation C/o Intellevate

20090239294 - Coaxial tissue block puncher set: A coaxial tissue block puncher set comprises a carrier mechanism, the first, second and third operating mechanisms being respectively installed at proper positions thereon, while each of the operating mechanisms respectively has a base and a lifting unit being movingly installed on the base, wherein lifting unit of the first... Agent: Frenkel & Associates

20090239295 - Dedifferentiated, programmable stem cells of monocytic origin, and their production and use: The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20090239296 - Compositions and methods for modifying cell surface glycans: Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090239297 - Avian cell lines useful for the production of substrates of interest: The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a basic culture medium. The invention also relates to the cells... Agent: Buchanan, Ingersoll & Rooney PC

20090239298 - Methods of generating embryoid bodies using three dimensional scaffolds: A method of generating embryoid bodies is provided. The method comprising culturing undifferentiated embryonic stem cells on a three dimensional scaffold under conditions suitable for formation of embryoid bodies, thereby generating the embryoid bodies.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090239299 - Autologous tissue harvesting and irrigation device: The present invention includes a harvesting and irrigation device, a method and a kit for the collection of viable fat cells and/or adipose tissue with decreased handing and improved yield and viability.... Agent: Chalker Flores, LLP

20090239300 - Separating material and method for collecting cell or the like using the same: The present invention provides a novel material useful for selectively isolating a cell such as monocyte and the like or a protein from a body fluid and a production method thereof, a physiological material using the material and an isolation material using the physiological material, as well as a method... Agent: Sughrue Mion, PLLC

20090239301 - Use of vinca alkaloids and salts thereof: An agent containing a vinca alkaloid or its pharmacologically acceptable salt as an active ingredient can induce insulin production and/or secretion of non-neoplastic cells derived from the pancreas.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090239304 - Bioactive peptide for cell adhesion: Implantable devices for adhering eukaryotic cells and devices providing a substrate for eukaryotic cell growth and/or differentiation in vitro are described. Each device comprises a scaffold that is coated with a protein comprising an adhesive polypeptide that has at least 90% sequence identity to a specific peptide sequence within domain... Agent: Ratnerprestia

20090239302 - Method for constructing functional living materials, resulting materials and uses thereof: The invention concerns a method for constructing a functional living biomaterial, characterized in that it consists in assembling layer by layer (3D) a matrix and 2D layers of functional living cells by controlling their interactions and 3D structuring based on the desired organization and final shape of the biomaterial, wherein... Agent: Nixon & Vanderhye, PC

20090239303 - Ultrasonic machining fabrication of guided tissue generation surfaces and tissue scaffolds: Ultrasonic machining is used to fabricate at least a portion of patterned surfaces that are used directly or indirectly for guided tissue generation. Tissues may be cultivated directly in the patterned surfaces or the patterned surfaces may be used as molds for polymer tissue scaffolds.... Agent: Ip & Internet Law North, LLC

20090239305 - Gene recombination exchange system for stable gene modification in human es cells: A method of creating a human pluripotent transgenic stem cell, wherein heterologous DNA is inserted into specific “hot-spots” in the genome where stable and high gene expression may occur, is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a pluripotent stem cell line, and (b) inserting... Agent: Quarles & Brady LLP

  
09/17/2009 > patent applications in patent subcategories. class, title,number

20090233269 - Detection of a target in a preservative solution: This invention relates to methods, articles and compositions useful in detecting target substances in an alcoholic preservative solution, and for identifying sensors useful for binding to such targets. The methods allow for the simultaneous performance of sufficient fixation of a sample and binding of a detectable sensor to a target... Agent: Theodore Allen, Esq. Hologic Inc.

20090233268 - Detection of biomarkers and biomarker complexes: The invention features methods and devices for the detection of biomarker complexes and their components and for the sequential detection of multiple epitopes of a biomarker. The invention also features methods for diagnosing disease and evaluating the efficacy of treatment of a subject with a disease.... Agent: Clark & Elbing LLP

20090233267 - Methylated tat polypeptides and methods of use thereof: The present invention provides isolated methylated Tat peptides; and compositions comprising the peptides. The present invention further provides isolated antibodies specific for a Lys-51-methylated Tat polypeptide. Also provided are methods of identifying agents that inhibit Lys-51 methylation of a Tat polypeptide. The present invention further provides methods of treating an... Agent: Bozicevic, Field & Francis LLP

20090233266 - Structure of the hepatitis c virus ns2 protein: The present invention provides a crystallized C-terminal domain of an NS2 protein of hepatitis C virus, methods of producing the same and methods of use thereof. The present invention also relates to structural elements of the C-terminal domain of hepatitis C virus NS2 protein, and methods of inhibiting hepatitis C... Agent: Thompson Coburn LLP

20090233309 - Biological specimen collection/transport compositions and methods: Disclosed are compositions for collecting, storing, and transporting populations of nucleic acids from biological specimens, and clinical, forensic, or environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the... Agent: Haynes And Boone, LLPIPSection

20090233304 - Biomarkers for inflammatory bowel disease and irritable bowel syndrome: The present invention provides compositions and their use in diagnosing and/or distinguishing inflammatory bowel disease and irritable bowel syndrome.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090233305 - Biomarkers for inflammatory bowel disease and irritable bowel syndrome: The present invention provides compositions and their use in diagnosing and/or distinguishing inflammatory bowel disease and irritable bowel syndrome.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090233306 - Biomarkers for inflammatory bowel disease and irritable bowel syndrome: The present invention provides compositions and their use in diagnosing and/or distinguishing inflammatory bowel disease and irritable bowel syndrome.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090233278 - Branched-chain amino acid aminotransferase gene and use thereof: The present invention relates to a branched-chain amino acid aminotransferase gene and a use thereof, particularly, to a brewery yeast for producing alcoholic drinks with enhanced flavor, to alcoholic drinks produced with said yeast and to a method for producing said drinks. More particularly, the present invention relates to a... Agent: Drinker Biddle & Reath (dc)

20090233281 - Diagnostic marker for allergy: More particularly, the present invention provides a diagnostic reagent, particularly a diagnostic reagent for allergy, or a reagent for detecting a mast cell and/or a blastogenic T cell, comprising one or more means for measuring CHD2, which is/are selected from the group consisting of a primer, a nucleic acid probe... Agent: Leydig Voit & Mayer, Ltd

20090233274 - Drug development target protein and target gene, and method of screening: The present invention provides novel target proteins and target genes for drug discovery, and the means that enable the development of novel drugs using the same. More particularly, the present invention provides NCS proteins and genes thereof; screening methods for drug (for example, anti-central nervous disease drug); agents for regulating... Agent: Leydig Voit & Mayer, Ltd

20090233275 - Eotaxin-3 in eosinophilic esophagitis: Eotaxin-3, as a marker for eosinophilic esophagitis and methods of assessing, mitigating, and monitoring eosinophilic esophagitis by altering eotaxin-3 and/or CCR3 function, are disclosed.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20090233298 - Fig4 gene mutations in neurodegeneration: The present invention relates to neurological disease, in particular to mutations in the FIG4 gene. The present invention also provides assays for the detection of variant FIG4 alleles, and assays for detecting FIG4 polymorphisms and mutations associated with disease states such as ALS.... Agent: Casimir Jones, S.c.

20090233301 - In vitro system for assessing immune activity using pig immune cells: An in vitro system in which immune cells of a non-immunized pig are used for assessing immunoactivity of a substance.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090233302 - Labeled reactants and their uses: Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components, such as enzymes, are reduced, minimized and/or eliminated.... Agent: Pacific Biosciences Of California, Inc.

20090233300 - Markers for diagnosis of pulmonary inflammation and methods related thereto: The present invention is related to the novel discovery of a number of genes that were identified as systemic markers of pulmonary inflammation. This discovery allows for development of a novel tool for reliable, rapid and efficient assessment of therapeutic responses and enables design of novel therapies targeted against diseases... Agent: Sheridan Ross PC

20090233292 - Method and kit for identification of genetic polymorphisms: Provided herein are primer sets, kits, and methods for identifying mtDNA polymorphisms in a sample. In one embodiment, the primer sets, kits and methods are directed to identifying global haplogroups (“Global”). In another embodiment, the primer sets, kits, and methods are directed to identifying specific European haplogroups (“European”).... Agent: Blank Rome LLP

20090233276 - Method enabling the use of extracellular ribonucleic acid (rna) extracted from plasma or serum to detect, monitor or evaluate cancer or premalignant conditions: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid)-RNA complexes, protein-RNA... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090233284 - Method for the simultaneous detection of mutations occurring in related genomes, exploiting mobility variations in 2-d electrophoresis of dna duplexes undergoing differential helix-coil transition in a denaturing gradient: A method for the simultaneous mutation detection exploiting the variable electrophoretic mobility of related DNA samples, caused by the differential onset of helix-coil transition in denaturing gradients, comprises the following subsequent steps: a) preparation of DNA samples; b) fragmentation of the samples through a first restriction; c) terminal labeling of... Agent: Greenberg Traurig LLP (la)

20090233280 - Method of acquiring information regarding base sequence and information reading device for the same: Information regarding a base sequence of a target nucleic acid is acquired by preparing a sample comprising the target nucleic acid hybridized with a primer or a sample comprising the target nucleic acid containing a promoter sequence, a polymerase, a nucleotide derivative having an electrochemically convertible moiety; allowing the three... Agent: Fitzpatrick Cella Harper & Scinto

20090233279 - Methods and compositions for predicting death from cancer and prostate cancer survival using gene expression signatures: The emerging concept of cancer stem cells suggests that activation in transformed cells of “sternness” genetic pathways (e.g., normal stem cells' self-renewal pathways) may contribute to the survival life cycle of cancer stem cells, and to tumor progression and metastasis of the malignancy. Thus, activation of “sternness” genes in cancer... Agent: Fenwick & West LLP

20090233303 - Methods for assessing breakdown products and stability of sirna and other target oligonucleotides: The disclosure provides methods and compositions for assessing by sequencing the type and quantity of in vivo or in vitro breakdown products and stability of nucleic acids such as small interfering RNA (siRNA) and other target oligonucleotides. In general, the disclosed methods involve the use of tester oligonucleotides that comprise... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090233307 - Methods for detection of single strand breaks in dna: Methods are provided for detecting single strand breaks in DNA sample comprising: contacting the DNA with a neutral hydroxylamine, denaturing the DNA and detecting single strand breaks in the denatured DNA. Methods are also provided for the detecting single strand breaks in DNA from a cell, the methods comprising lysing... Agent: Myers Bigel Sibley & Sajovec

20090233286 - Methods of diagnosis and prognosis of pancreatic cancer: Disclosed herein are methods of diagnosing pancreatic cancer in a subject. Also provided are methods of monitoring the efficacy of a therapeutic treatment of pancreatic cancer as well as methods of determining the likelihood that a subject having pancreatic cancer will survive, and methods of determining the suitability of a... Agent: Cooper & Dunham, LLP

20090233297 - Microrna markers for recurrence of colorectal cancer: The present invention concerns methods and compositions for identifying a miRNA profile for a particular condition, such as colorectal cancer, and using the profile in the diagnosis and/or prognosis of a patient for a condition, such as colorectal cancer and colorectal cancer recurrence or response to therapy.... Agent: Fullbright & Jaworski L.L.P.

20090233272 - Multiplexed nucleic acid analysis with high specificity: A test kit and method includes amplification and extension primers that are selected to allow multiplex PCR and extension at increased specificity. Preferably, the extension primers include a tag that hybridizes with a capture probe on a biochip, wherein the tag is distinct from the target nucleic acid sequence to... Agent: Fish & Associates, PC Robert D. Fish

20090233290 - Mutant seprs, and method for site-specific introduction of phosphoserine into protein using the same: A mutant SepRS which is suitable for a site-specific introduction of phosphoserine into a protein is prepared by analyzing the structure and functions of a phosphoseryl-tRNA synthetase (SepRS) derived from an archaebacterium. A mutant SepRS composed of an amino acid sequence depicted in SEQ ID NO:2, in which any one... Agent: Birch Stewart Kolasch & Birch

20090233289 - Novel dna threading intercalators: m

20090233308 - Novel method of assaying nucleic acid using labeled nucleotide: A novel method is provided to assay at least one nucleic acid. According to this method, a nucleic acid polymerization reaction is conducted in a nucleic acid polymerization reaction system, which contains (A) the at least one nucleic acid as a template, (B) at least one nucleotide monomer labeled with... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090233291 - Paired end sequencing: An embodiment of a method for obtaining a DNA construct comprising two end regions of a target nucleic acid in an in vitro reaction is described that comprises the steps of: fragmenting a large nucleic acid molecule to produce a target nucleic acid molecule; ligating a recombination adaptor element to... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090233299 - Physiogenomic method for predicting statin injury to muscle and muscle side effects: The present invention relates to the use of genetic variants of associated marker genes to predict an individual's susceptibility to muscular injury and muscular side effects in response to statin therapy. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present... Agent: Cantor Colburn, LLP

20090233277 - Primer generation rolling circle amplification: A method of amplifying a nucleic acid is provided which comprises: generating a first nucleic acid primer from a first nucleic acid sequence; combining the first nucleic acid primer with a first polymerase and a first circular nucleic acid probe, wherein the first circular nucleic acid probe contains at least... Agent: Knobbe Martens Olson & Bear LLP

20090233288 - Primer set for gene amplification, reagent for gene amplification including the same, and uses thereof: Primer sets for amplifying two genes (the CYP2C9 gene and the VKORC1 gene) by a gene amplification method are provided, wherein the primer sets can amplify respective target regions of the two genes specifically and efficiently in the same reaction system simultaneously. Two pairs of primer sets are used including... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090233282 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20090233287 - Production of compounds in a recombinant host: The present invention provides a recombinant Penicillium chrysogenum strain characterized in that a gene selected from the list consisting of penDE, pcbAB and pcbC is inactivated and the use of such a strain for the preparation of a compound of interest. Furthermore, it is an object of the present invention... Agent: Nixon & Vanderhye, PC

20090233271 - Species-specific and quantitative detection of cns tissue in meat and meat products: The present invention concerns a method for the species-specific and quantitative detection of CNS tissue in meat and meat products of the ruminant species bovine, ovine and caprine or porcine by a real-time PCR method, using glial fibrillary acidic protein (GFAP) messenger (m)-RNA. The method is very reliable and can... Agent: Clark & Brody

20090233285 - Specific method of prostate cancer detection based on pca3 gene, and kits therefor: The present invention relates, in general, to prostate cancer. More specifically, the present invention relates to a method to diagnose prostate cancer in a patient by detecting a PCA3 sequence, and more particularly a PCA3 RNA, the PCA3 sequence detected in a sample from the patient being specifically associated with... Agent: Goudreau Gage Dubuc

20090233283 - Stable compositions for nucleic acid amplification and sequencing: The present invention is directed to compositions comprising mixtures of reagents, including thermostable enzymes (e.g., thermostable DNA polymerases), buffers, cofactors and other components, suitable for immediate use in nucleic acid amplification or sequencing techniques without dilution or addition of further components. The compositions contain no stabilizing agents (e.g., glycerol or... Agent: Life Technologies Corporation C/o Intellevate

20090233296 - Thiamin production by fermentation: The present invention provides a method for producing thiamin products using a microorganism containing a mutation that causes it to overproduce and release thiamin products into the medium. Biologically pure cultures of the microorganisms and isolated polynucleotides containing the mutations are also provided. In addition, methods for detecting a pathogenic... Agent: Stephen M. Haracz, Esq. Bryan Cave LLP

20090233273 - Transgenic aloe plants for production of proteins and related methods: The present inventions provide transgenic aloe plants and recombinant constructs for transforming aloe plants, aspects of which, may be applied to other monocots. The recombinant constructs may include one or more DNA sequences encoding mammalian proteins and at least one promoter capable of directing the expression of recombinant proteins in... Agent: Cyr & Associates, P.A.

20090233295 - Trim59 directed diagnostics for neoplastic disease: Disclosed are methods for diagnosing cancer in a test cell sample or fluid sample by detecting an increase in the level of expression of TRIM59 in the test cell sample or fluid sample as compared to the level of expression of TRIM59 in a control cell sample or fluid sample... Agent: Wilmerhale/boston

20090233293 - Ttk directed diagnostics for neoplastic disease: Disclosed are methods for diagnosing cancer in a test cell sample or fluid sample by detecting an increase in the level of expression of TTK in the test cell sample or fluid sample as compared to the level of expression of TTK in a control cell sample or fluid sample... Agent: Wilmerhale/boston

20090233294 - Uhrf1 directed diagnostics for neoplastic disease: Disclosed are methods for diagnosing cancer in a test cell sample or fluid sample by detecting an increase in the level of expression of UHRF1 in the test cell sample or fluid sample as compared to the level of expression of UHRF1 in a control cell sample or fluid sample... Agent: Wilmerhale/boston

20090233314 - Functional domain and associated molecule of dock2 essentially required in lymphocyte migration: The present invention is related to provide a method for screening a substance interfering in the association of DOCK2 and ELMO1, a method for screening a substance interfering in the association of ELMO1 and Tiam1, and a method for searching a therapeutic agent for immune related diseases such as allergy,... Agent: Foley And Lardner LLP Suite 500

20090233312 - Methods and assays to assess cardiac risk and ischemia: The invention provides methods and apparatus to assess cardiac risk and ischemia by detecting or analyzing cardiac troponin levels. Also provided are methods to detect low levels of cardiac troponin in physiological fluid samples.... Agent: Gregory T. Pletta Nanosphere, Inc.

20090233311 - Methods and substances for the diagnosis and therapy of sepsis and sepsis-like systemic infections: Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.... Agent: Millen, White, Zelano & Branigan, P.C.

20090233310 - Particle agglutination in a tip: An apparatus and a related method for performing particle agglutination reactions in a single, disposable probe tip are disclosed. The probe tip includes a sample cavity for sample acquisition, at least one flanking cavity for the capture of particles by centrifugation or other means, a transition zone for the mixing... Agent: Hiscock & Barclay, LLP

20090233313 - Quantification and affinity characterization of antibodies for the diagnosis of disease using optical diffraction: The invention features methods and devices for the detection of antibodies. The invention also features methods for diagnosing disease and evaluating the efficacy of treatment of a subject with a disease.... Agent: Clark & Elbing LLP

20090233315 - Mage-c2 antigenic peptides and uses therefor: This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA... Agent: Fulbright & Jaworski, LLP

20090233317 - Repressor of skeletal muscle differentiation, nucleic acids coding therefor and the use thereof in diagnosis and therapy: Polypeptide sequences which play a part in the regulation of skeletal muscle differentiation, and nucleic acids coding therefor, and the use thereof in diagnosis and therapy are disclosed. Possible uses are also indicated for antibodies which are directed against corresponding epitopes of the GRIM1 polypeptide.... Agent: Arent Fox LLP

20090233318 - Methods of assaying vaccine potency: The present invention is related to methods of assaying potency of a vaccine composition, wherein the potency is a pre-defined minimum level of potential biological activity for the vaccine composition. The method includes providing a vaccine composition and delivering same to an antigen presenting cell, wherein the vaccine composition is... Agent: Dunlap Codding, P.C.

20090233316 - Protein, an antibody and measurement of the protein: A novel mammalian protein related to human hypothetical protein FLJ22662 (SEQ ID NO: 1) and homologous hypothetical proteins from mammal species other than Homo sapiens. The protein is expressed in neutrophils and is characterized as a phospholipase B of a novel family (PLB-II). The protein is characterized in comprising one... Agent: Porter Wright Morris & Arthur, LLP Intellectual Property Group

20090233319 - Method for evaluating skin condition using squamous cell carcinoma antigen as marker: The invention provides a method for evaluating skin condition using squamous cell carcinoma antigen (SCCA) expression in skin stratum corneum cells as a marker.... Agent: Fish & Richardson PC

20090233320 - Gene encoding novel luciferase: e

20090233321 - Reducing/oxidizing activity of maternal urine as indicator of fetal gender related characteristics: The present invention provides a method for determining the gender of an unborn child by assaying the overall reducing/oxidizing or redox activity of the maternal urine or other body fluid. The method can be used to determine fetal gender at any time point during the entire pregnancy, the earliest being... Agent: Axinn, Veltrop & Harkrider LLP Attn. Michael A. Davitz

20090233322 - Colorimetric method and reagent used for the same: The present invention provides a colorimetric method that can perform a simple and reliable analysis in a short time. The method includes transferring an electron from an analyte to a coloring reagent that produces color by reduction via a mediator by using an oxidoreductase; and performing qualitative or quantitative analysis... Agent: Hamre, Schumann, Muller & Larson, P.C.

20090233323 - Method for analysis of nkt cell function: The present invention provides a superior method of functional analysis of NKT cells, which enables function analysis of low frequency NKT cells, is independent of the function of autologous APCs, and can avoid an influence of secondary factors and the like. More specifically, the present invention provides a method of... Agent: Leydig Voit & Mayer, Ltd

20090233326 - Method for induction of the differentiation of visceral fat cell: A culture medium is disclosed for inducing the differentiation of visceral preadipocytes into mature visceral adipocytes; the culture medium contains 0.85 to 100 ng/mL insulin and 50 to 250 ng/mL IGF-1. Also disclosed is a method for using the culture medium to induce the differentiation of visceral preadipocytes into mature... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090233324 - Methods for diagnosing cancer using samples collected from a central vein location or an arterial location: The invention encompasses methods for selectively enriching in rare particles from blood samples harvested from the vein jugular vein the femoral vein, the subclavian vein, or an artery. These rare particles can be circulating tumor cells, circulating stem cells, or fragments thereof. Blood samples harvested from different sources can contain... Agent: Wilson Sonsini Goodrich & Rosati

20090233325 - Screening method of nesfatin-1-action regulating substance or nesfatin-1-like action substance with the use of receptor protein selected from the group consisting of gpr3, gpr6 and gpr12: e

20090233327 - Surface modification in a manipulation chamber: A device for manipulating biological material, the device including at least one electrode and a photoconductive material configured to receive the biological material; and a light source configured to illuminate the photoconductive material so as to modulate an electric field, wherein the electric field is configured to manipulate the biological... Agent: Life Technologies Corporation C/o Intellevate

20090233328 - Method for reading images, in particular for studying the development of biofilm in a culture medium: A method for reading images of a base of a plate provided with at least one well containing a culture medium of micro-organisms includes: i) forming a opaquing layer covering a surface of the culture medium to form a reading base; and ii) imaging, at specific time intervals, the base... Agent: Ip Group Of Dla Piper LLP (us)

20090233330 - Method and apparatus for measuring changes in cell volume: A method and apparatus for measuring changes in cell volume generally includes introducing cells into a chamber having a volume between 2 and 100 times the volume of the introduced cell. A first electrically conductive extracellular fluid is introduced into the chamber and a current is applied. The voltage induced... Agent: Simpson & Simpson, PLLC

20090233329 - Microfluidic chamber assembly for mastitis assay: The present invention relates to a device and method for the detection of mastitis or other disease from a body fluid of a mammal for example from cow's milk. The device and method relates to a wedge microfluidic chamber for using a minimal amount of fluid and being able to... Agent: Passe' Intellectual Property, LLC

20090233331 - Method and apparatus for preparing cytological specimens: An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station... Agent: VistaIPLaw Group LLP

20090233332 - Method of producing recombinant protein: An object of the present invention is to provide a method of mass-producing recombinant protein by the liquid culture method with koji molds as host. According to the present invention, it is provided a method of producing recombinant protein by using the recombinant koji molds which are obtained by transforming... Agent: Sughrue Mion, PLLC

20090233333 - Methods for preventing gluconoylation of proteins: The present invention relates to methods of preventing glyconoylation of polypeptides produced in micororganisms.... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20090233334 - Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale: The present invention provides a novel method for culturing cells as well as a novel method for producing a recombinant protein by culturing cells at large scale (up to 1,500 L nominal volume and 750 L working volume), whereby an inflated bag provides a sterile, disposable cultivation chamber. The inflated... Agent: Markus Hildinger

20090233335 - Variant humicola grisea cbh1.1: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are... Agent: Victoria L. Boyd Genencor International, Inc.

20090233270 - Secreted and cytoplasmic tumor endothelial markers: To gain a better understanding of tumor angiogenesis, new techniques for isolating endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, over 170 genes predominantly expressed in the endothelium were identified.... Agent: Banner & Witcoff, Ltd.

20090233336 - Process for producing chondroitin: A method for producing a chondroitin (CH) with a desired sugar chain length; a method for producing a fraction containing a CH with a substantially single sugar chain length; etc. There is provided a method for producing a CH with desired sugar chain length, comprising alternately performing the steps (a)... Agent: Knobbe Martens Olson & Bear LLP

20090233337 - Chemoenzymatic process for the stereoselective preparation of (r)-gamma-amino-beta-hydroxybutyric acid [(r)-gabob) and (r)-carnitine: The present invention provides a chemoenzymatic process for the preparation of (R)-GABOB and (R)-carnitine employing lipase-mediated resolution of 3-hydroxy-4-tosyloxybutanenitrile as the key step. The drawing accompanying this specification represents the preparation of racemic 3-hydroxy-4-tosyloxybutanenitrile, its lipase-mediated kinetic resolution and its successful application in the preparation of (R)-GABOB and (R)-carnitine.... Agent: Greenlee Winner And Sullivan P C

20090233338 - Process for recovery of polyhydroxyalkanoates from biomass: Systems and processes for the recovery of polyhydroxyalkanoates (“PHA”) from biomass are disclosed. In certain embodiments, the process includes the steps of extracting at least a portion of PHA from a disrupted quantity of PHA-containing biomass with an acetin solvent to produce a biomass phase (including residual biomass) and a... Agent: K&l Gates LLP Henry W. Oliver Building

20090233339 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Potter Anderson & Corroon LLP Attn: Janet E. Reed, Ph.d.

20090233340 - Use of erythromycin as a selective antimicrobial agent in the production of alcohols: A process for the use of low concentration levels of Erythromycin to eliminate or control the growth of unwanted or undesirable bacteria (contaminating bacteria) in the fermentation production of alcohols without inhibition of the growth or replication of the yeast.... Agent: Welsh & Flaxman LLC

20090233341 - Process for producing biogas: A production method of a biogas of the present invention comprises carrying out hydrogen fermentation of a subject solution containing organic matter with the use of a hydrogen fermentation microorganism, in which according to a correlation between a concentration of a predetermined substrate in a liquid to be processed containing... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090233342 - Heterologous expression of proteorhodopsin photosystem: The invention relates to functional heterologous expression of proteorhodopsin photosystems in cells and the use of such proteorhodopsin photosystems in methods for increasing energy content of a cell, redirecting carbon flow in a cell, increasing a production of a carbon-based compound in a cell and increasing production of a metabolite... Agent: Wolf Greenfield & Sacks, P.C.

20090233343 - Affinity purification of protein: We describe fusion proteins comprising a bacterial immunity polypeptide and their use in affinity purification of protein complexes.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090233344 - Pancreatin and method for reducing the viral and microbial contamination of pancreatin: The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided... Agent: Mccormick, Paulding & Huber LLP

20090233345 - Catalytic domains of beta(1,4)-galactosyl transferase i having altered donor and acceptor specificities, domains that promote in vitro protein folding, and methods for their use: Disclosed are methods and compositions that can be used to synthesize oligosaccharides; mutants of galactosyltransferases having altered donor and acceptor specificity; methods for increasing the immunogenicity of an antigen; and polypeptide stem regions that can be used to promote in vitro folding of polypeptides, such as the catalytic domain from... Agent: Edwards Angell Palmer & Dodge LLP

20090233346 - Production of polyunsaturated fatty acids in oleaginous yeasts: The present invention relates to methods for the production of ω-3 and/or ω-6 fatty acids in oleaginous yeast. Thus, desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-γ-linoleic acid (DGLA); STA to eicosatetraenoic... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090233347 - Production of polyunsaturated fatty acids in oleaginous yeasts: The present invention relates to methods for the production of ω-3 and/or ω-6 fatty acids in oleaginous yeast. Thus, desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-γ-linoleic acid (DGLA); STA to eicosatetraenoic... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090233348 - Method for isolating proteins from production cells: e

20090233349 - Metal nanowires with an oxide sheath and production method for same: A one-dimensional composite structure which comprises at least one nanowire. The nanowire comprises a metal core and a metal oxide sheath.... Agent: Greenblum & Bernstein, P.L.C

20090233350 - Respiratory apparatus with a bioburden indicator: A respiratory apparatus includes a bioburden indicator, having an input valve for the entry of air to be analysed, an element for bioburden analysis, and a suction valve suited to be connected to a suction system to suck up the air to be analysed.... Agent: Carter, Deluca, Farrell & Schmidt, LLP

20090233351 - Method for controlling pressure-difference bubble transfer, and gas exchange apparatus, electrical conductivity measuring apparatus, total organic carbon measuring apparatus, reactor and cell culture apparatus using the method: In order to control bubble removal or mixing in a flow channel, bubble transfer between flow channels (1, 2) is controlled by disposing first flow channel (1) for flow of a first fluid of liquid or gas and second flow channel (2) for flow of a second fluid of liquid... Agent: Cheng Law Group, PLLC

20090233352 - Method on clinical applications in head neck cancer by using dsg3 molecule for predicting malignant degree of cancer, serving as a molecular target and using rna jamming sequence on inhibition-specific of dsg3 expression: The present invention provide a method for analyzing the DSG3 overexpression in tumor tissues with clinical features of cancer cells to validate that overexpression is relates to size, depth and migration of tumor. Therefore, DSG3 overexpression is capable for using in clinical applications, determining malignant degree of tumor, serving as... Agent: Nikolai & Mersereau, P.A.

20090233353 - Multipotent adult stem cells and methods for isolation: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20090233354 - Multipotent adult stem cells and methods for isolation: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20090233355 - Compositions and methods for culturing embryos and oocytes: The present invention relates to an oocyte and/or embryo culture medium. The medium includes 0.0003 to 750 ng/ml IGF-II, or a variant or analogue thereof, and further includes either or both of 0.01 to 50 μg/ml plasminogen, or a variant or analogue thereof, and 0.01 to 50 μg/ml urokinase plasminogen... Agent: Birch Stewart Kolasch & Birch

20090233356 - Tissue engineered cellular sheets, methods of making and use thereof: The disclosure provides methods and compositions to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel. Since the tissue can surround and envelope the stent, foreign body responses to the stent material are reduced and... Agent: Fish & Richardson P.C.

20090233358 - Method of regulating a phosphorylated protein-mediated intracellular signal transduction using an antibody specifically binding to the phosphorylated protein: There are provided a method of regulating a phosphorylated protein-mediated intracellular signal transduction comprising intracellularly expressing an antibody that specifically binds to the phosphorylated protein and an expression system for intracellular expression of the antibody. The method and system are effectively used in the investigation, prevention, or treatment of diseases... Agent: Sughrue Mion, PLLC

20090233359 - Polymers and complexes for delivery of nucleic acids to intracellular targets: A complex includes a nucleic acid and a cationic polymer with at least one side chain coupled to the nucleic acid. The at least one side chain including an acid degradable amine-bearing ketal or acetal linkage.... Agent: Tarolli, Sundheim, Covell & Tummino, LLP

20090233357 - Targeted delivery of compounds using multimerization technology: There is disclosed herein subunits and multimers of subunits suitable for use in inducing the transport of one or more cargo substances into a cell and in some instances across a cell. The subunits may have a targeting domain such a antibody or antibody fragment, a multimerization domain, such as... Agent: National Research Council Of Canada 1200 Montreal Road

20090233360 - Methods and compositions for culturing of neural precursor cells: The present invention provides methods and compositions for the propagation and expansion of neural precursor cells (NPCs). NPCs may be used in the clinical implementation of stem cell therapy to treat disorders such as Parkinson's disease, Huntington's disease, neuropathic pain and other diseases of the central nervous system. The large-scale... Agent: Fulbright & Jaworski L.L.P.

20090233361 - Tissue bioreactor: A bioreactor comprising, two chambers in fluid communication, a tissue matrix held in place between, and separating, the two chambers, each side of the tissue matrix in fluid communication with one of the two chambers, each chamber comprising at least one port.... Agent: Gowling Lafleur Henderson LLP

20090233362 - Porous scaffold, method of producing the same and method of using the porous scaffold: A porous scaffold having pores for seeding cells characterized in that, in the outer peripheral face of the porous main body having the pores for seeding cells, a porous membrane having pores smaller than the cells is located. Thus, it is possible to provide a porous scaffold whereby the cells... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090233363 - Dedifferentiated, programmable stem cells of monocytic origin, and their production and use: The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20090233364 - Method to engineer mapk signaling responses using synthetic scaffold interactions and scaffold-mediated feedback loops: Synthetic scaffold interactions and scaffold-mediated feedback loops are used to engineer MAPK signaling responses in cells.... Agent: Richard Aron Osman

20090233365 - Arginine-conjugated bioreducible poly(disulfide amine) polymers for gene delivery systems: An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with plasmid DNA. ABP is biodegraded under reducing conditions, such as the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian... Agent: Alan J. Howarth

20090233366 - Composition for introduction of nucleic acid: wherein (R1)n represents a polyamino acid residue consisting of a total of n amino acid residues, which are identical to or different from one another, the n residues being selected from an arginine residue, a lysine residue, and a histidine residue, and n being an integer of from 4 to... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20090233367 - Method of transferring substance into cell: There is provided a method by which multiple types of substances desired to be transferred into cells can be continuously transferred into multiple types of cells by a convenient procedure, a cell in which the substance desired to be transferred into cells has been taken up by this method, and... Agent: Fitch, Even, Tabin & Flannery

20090233368 - Allele suppression: e

  
09/10/2009 > patent applications in patent subcategories. class, title,number

20090226876 - Compositions and methods for cardiovascular surgery: The present invention relates to tissue preservation for autologous and heterologous transplantation. In particular the present invention provides compositions and methods for the long-term storage of surgical conduits ex vivo for subsequent use in coronary artery bypass grafting.... Agent: Peter G. Carroll Medlen & Carroll., LLP

20090226877 - Flush preservation solution: method for the preparation thereof; use thereof in transplantation including organs from heart beating or non heart beating donors, in surgery including any situation of warm or cold ischaemia, cardioplegia or open heart surgery, whole limb or whole body preservation in experimentation on living tissues or in culturing and preserving... Agent: Jacobson Holman PLLC

20090226875 - Use of a composition for preserving organs and members: Use of a composition which contains at least one semifluorinated alkane compound and at least one liquid siloxane, wherein the composition is of a density in a range of 0.8 to 1.5 g/cm3, for preserving organs or limbs.... Agent: Merchant & Gould PC

20090226878 - Apparatus and method for perfusing an organ or tissue for isolating cells from the organ or tissue: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures. The methods further include perfusing... Agent: Oliff & Berridge, PLC

20090226880 - Method for staining cells for identification and sorting: The present invention provides novel methods of cell staining, such as bovine sperm, using electroporation or osmolality treatments at viability-enhancing temperatures. Furthermore, methods of highly efficient cell sorting that are especially suitable in sorting bovine sperm using novel cell staining procedures are also provided.... Agent: Akerman Senterfitt

20090226879 - Protein-free gamete and embryo handling and culture media products: This invention discloses a substantially protein-free cell culture solution for assisted reproductive technologies and methods of use thereof.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090226881 - Multiple mode multiplex reaction quenching method: Methods for balancing multiplexed PCR reactions are provided which exploit differences in primer and amplicon Tms. The methods may be controlled by a computer process. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.... Agent: Jesse A. Hirshman, Esq.

20090226883 - Devices and methods for detecting analytes in fluid samples: A device for detecting the presence or amount of an analyte in a fluid sample and method thereof, comprises a sample collector and a receiving cup for receiving and holding the sample collector within the receiving cup. The sample collector contains a compressible absorbent member for collecting the fluid sample,... Agent: Inverness Medical Innovations / Wsgr Wilson Sonsini Goodrich & Rosati, P.C.

20090226882 - Method for identifying fungicidally active compounds that are based on ipp isomerases: The invention relates to a method for identifying fungicides, to the use of fungal IPP isomerase for identifying fungicides, and to the use of inhibitors of the IPP isomerase as fungicides.... Agent: Womble Carlyle Sandridge & Rice, PLLC

20090226884 - Method of quantitative analysis of oxidized protein, labeling reagents for quantitative analysis of oxidized protein and labeling reagent kit for quantitative analysis of oxidized protein: Oxidized proteins, which have undergone oxidative modifications, are labeled with labeling reagents and quantified by mass spectrometry. In this process, a first labeling reagent, which is capable of reacting with the oxidized proteins, and a second labeling reagent, which has the same chemical structure as the first labeling reagent and... Agent: Kanesaka Berner And Partners LLP

20090226890 - Assays and systems for rapid detection of pathogens: Assay systems and methods are provided for detecting a target pathogen, such as a microorganism (e.g., bacterium, bacterial toxin) which may be present in a fluid or other location. The method can include linking a magnetic microparticle to a first epitope of the target microorganism in a fluid via a... Agent: Sutherland Asbill & Brennan LLP

20090226887 - Device for binding a target entity to a bait entity and detection methods using the same: The present invention pertains to a device for binding a target entity onto a bait entity that is immobilized on said device, comprising: a) a lipid layer having a negative net charge in an aqueous solution at a neutral pH; b) a two-dimensional matrix of anchoring complexes that are bound... Agent: Jacobson Holman PLLC

20090226888 - Diagnostic primers and method for detecting avian influenza virus subtype h5 and h5n1: The present invention provides primers directed to conserved regions of the HA and NA genes of avian influenza virus subtypes H5 and H5N1, and provides a method for detecting avian influenza subtype H5 or H5N1.... Agent: Klarquist Sparkman, LLP

20090226889 - Methods and compositions for detecting cns viruses: The present invention generally relates to a molecular test of enterovirus, herpes simplex virus-1 and -2, and/or Varicella-Zoster virus, in order to identify patients with a viral infection, in particular a viral infection of the central nervous system. Accordingly methods and compositions are disclosed to determine the presence or absence... Agent: Foley & Lardner LLP

20090226885 - Nucleic acid sequences that can be used as primers and probes in the amplification and detection of sars coronavirus: The present invention is related to nucleic acid sequences that can be used in the field of virus diagnostics, more specifically the diagnosis of infections with a novel human coronavirus causing Severe Acute Respiratory Syndrome (SARS). With the present invention nucleotide sequences are provided that can be used as primers... Agent: Myers Bigel Sibley & Sajovec

20090226886 - Primers and probes for the detection of hiv: Provided herein are primer/probe sets useful for detecting HIV (HIV-1) in a test sample. The primer/probe sets can be employed according to nucleic acid amplification procedures including PCR, real-time quantitative PCR, or RT-PCR. The primer/probe sets can also be provided in the form of a kit with other reagents for... Agent: Knobbe Martens Olson & Bear LLP

20090226907 - Assay for detection of telomerase activity: The present invention relates generally to the field of diagnostic and prognostic assays such as diagnostic assays for conditions associated with telomerase activity. More particularly, the present invention provides an assay for measuring telomerase activity as an indicator of cancer, an inflammatory disorder and/or a condition involving embryogenesis and/or requiring... Agent: Knobbe Martens Olson & Bear LLP

20090226916 - Automated analysis of dna samples: The present invention provides a system and methods for deconvoluting mixed DNA samples. Applications developed according to the invention may be used for resolving two or more person mixtures into easy to interpret contributor profiles and to perform automated statistical calculations. An automated analysis approach for mixed samples integrating hardware... Agent: Life Technologies Corporation C/o Intellevate

20090226908 - Biomarker and composition for diagnosis of preeclampsia: The present invention relates to a biomarker and a composition for diagnosis of preeclampsia. In accordance with one aspect of the present invention, there is provided a biomarker for diagnosis of preeclampsia using an enzyme selected from the group consisting of placental chondroitin 4-O-sulfotransferase 1 (C4ST), chondroitin 6-sulfotransferase (C6S), heparan... Agent: Christie, Parker & Hale, LLP

20090226923 - Compositions and methods of use of standardized mixtures: The present invention is directed to methods and compositions for evaluating nucleic acids, methods of preparing such compositions, and applications and business methods employing such compositions and methods. In particular, the present invention provides business methods for operating a gene expression measurement service.... Agent: Wilson Sonsini Goodrich & Rosati

20090226905 - Diagnosis and prognosis of colorectal cancer: The invention relates to a method of diagnosis of colorectal cancer in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being: transforming growth... Agent: Arent Fox LLP

20090226904 - Diagnosis and treatment of exocrine pancreatic dysfunction and diabetes: The present invention relates to association of one or more polymorphisms located in the human CEL gene to the occurrence of exocrine pancreatic dysfunction and a endocrine pancreatic dysfunction in the form of diabetes. The invention relates both to methods for diagnosing a predisposition to said diseases, classifying said diseases... Agent: Manelli Denison & Selter

20090226918 - Gene overexpressed in cancer: Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide... Agent: Davidson, Davidson & Kappel, LLC

20090226922 - Identification of antigen or ligand-specific binding proteins: The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090226913 - Identification of cancer biomarkers and phosphorylated proteins: Methods are provided for identifying proteins that are differentially expressed in disease state and normal cells. Stable isotope labeling of cells in culture allows for the identification of a multiplicity of proteins whose differential abundance in normal and disease state cells can be indicative of the disease state. Biomarkers are... Agent: Life Technologies Corporation C/o Intellevate

20090226926 - Materials and methods for detection of nucleic acids: Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second primers; amplifying the target nucleic acid by PCR using the first and second primers to generate an amplification product having a... Agent: Eragen Biosciences, Inc. C/o Foley & Lardner LLP

20090226919 - Method for constructing an operon containing translationally coupled genes: The present invention provides a method for constructing recombinant translationally coupled operons, a method for producing useful metabolites using the bacterium containing the coupled operons, and a method for monitoring gene expression.... Agent: Cermak & Kenealy LLP Acs LLC

20090226894 - Method for measuring resistance or sensitivity to docetaxel: The present invention relates to novel and useful methods that predict or monitor a patient's response to a molecule of the taxoid family by measuring the increase or decrease of specific genetic markers as compared to controls. The present invention also provides kits that predict of monitor patient's response to... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20090226910 - Method for the extraction and purification of nucleic acids on a membrane: The invention relates to a method for the extraction and detection of nucleic acids on a membrane, making it possible to identify the microorganisms present in low concentration in a liquid or gaseous medium, as well as a novel lysis composition comprising guanidium chloride and between 0.1 and 1% N-Lauroyl-Sarcosine... Agent: Nields, Lemack & Frame, LLC

20090226895 - Method of detecting vibrio parahaemolyticus via real-time pcr-hybridization: The present invention relates to an assay and methods for determining the presence of pathogenic V. parahaemolyticus in a sample. Determination should be made by detector. Via the assay, rapid, real-time detection of V. parahaemolyticus is possible.... Agent: Blanchard & Associates

20090226901 - Method of evaluating or selecting agents for preventing or improving pigmented spots: The object of the present invention is to provide a method for evaluating or selecting an agent having preventive or alleviative effects on spots, which method realizes reliable and effective screening of candidate substances of the agent; a method for predicting spot formation; and a method for analyzing the condition... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090226902 - Method to diagnose or screen for inflammatory diseases: The invention relates to the field of medical diagnostics. More specifically, the invention relates to methods to diagnose or screen for inflammatory condition or disease, including auto-inflammatory disease and affective disorder, in a subject, preferably a human subject, by assaying for a marker for an inflammatory disease. Provided is a... Agent: Traskbritt, P.C.

20090226912 - Methods and compositions for correlating genetic markers with prostate cancer risk: The present invention provides a method of identifying a subject as having an increased risk of developing prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of developing prostate cancer.... Agent: Myers Bigel Sibley & Sajovec

20090226906 - Methods and compositions for reducing nucleotide impurities: The disclosure provides methods and compositions for reducing nucleotide impurities in reagents and reaction mixtures. Generally, the methods of the invention involve the inclusion of so-called “scrubbing oligonucleotides” (or “scrubbers”) that preferentially incorporate nucleotide impurities, thereby reducing available free impurities. The disclosure further provides methods of sequencing a target nucleic... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090226909 - Methods and kits for determining predisposition to warfarin resistance: The present invention is of the high association of the 5417T allele of the VKORC1 gene with high coumarin dose requirements and which can be used to determine the predisposition of an individual to coumarin resistance. Specifically, the present invention provides methods and kits for determining the predisposition of an... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090226914 - Methods and products to target, capture and characterize stem cells: A method for identifying cancer stem cells, comprises reacting a plurality of cells comprising cancer stem cells with an anti-nucleolin agent to bind the anti-nucleolin agent to the cancer stem cells; and identifying the cancer stem cells that are bound to the anti-nucleolin agent from remaining cells of the plurality... Agent: Evan Law Group LLC

20090226925 - Methods for detecting circulating tumor cells: Nucleic acids and methods for amplifying and detecting mutant BRAF sequences are provided herein. In particular, nucleic acids and methods for amplifying and detecting BRAF sequences that encode the V600E BRAF mutant are provided herein.... Agent: Fish & Richardson P.C.

20090226900 - Methods for reducing contaminants in nucleic acid sequencing by synthesis: The disclosure provides methods that improve fidelity of the sequencing-by-synthesis reactions, including methods that reduce impurities and contamination in various reagents, reaction mixtures, and other components of the sequencing systems.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090226915 - Methods for screening, predicting and monitoring prostate cancer: Biomarkers are identified by analyzing gene expression data using support vector machines (SVM) to rank genes according to their ability to separate prostate cancer from normal tissue. Expression products of identified genes are detected in patient samples, including prostate tissue, serum, semen and urine, to screen, predict and monitor prostate... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20090226899 - Methods of b-cell epitope antigenic systems-discovery: A method is disclosed wherein an antigenic B-cell epitope is discovered by in vitro transcription and translation of pre-determined sequence on thermostable protein scaffolds detected by antibodies to a native protein. Immune reactivities of IgE B-cell epitopes from pre-determined IgE sequences from the constant region, engaged in binding to high... Agent: Swey-shen Alex Chen

20090226893 - Methods of studying tolerance in mhc-ii transgenic animals: Novel methods of testing the immunogenicity of variant antigens are provided. In particular, methods based on the use of transgenic animals are provided, wherein the transgenic animal is tolerised to a particular antigen and is then exposed to variants of the antigen and immune responses are determined. In one embodiment... Agent: Brooks Kushman P.C.

20090226921 - Methods to detect tumors using 20p1f12/tmprss2 expression: Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell membrane associated and secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided... Agent: Agensys C/o Morrison & Foerster LLP

20090226898 - Mitochondrial markers of ischemia: Damage to tissue, such as ischemic damage, can cause the release of mitochondrial markers. The released markers can be detected in a sample taken from a subject, indicating that the subject has suffered damage.... Agent: Steptoe & Johnson LLP

20090226924 - Modified oligonucleotides and applications thereof: Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof.... Agent: Life Technologies Corporation C/o Intellevate

20090226920 - Mutation in the regulatory region of gjb2 mediates neonatal hearing loss within dfnb1: Homozygous alterations in the gap junction protein GJB2 (connexin 26), within the DFNB1 locus, are responsible for up to 50% of autosomal recessive non-syndromic hearing impairment (NSHI). Mutations have been described throughout the coding region and more rarely, within the splice donor site. To further investigate the role of GJB2... Agent: Bromberg & Sunstein LLP

20090226927 - Nanowire-based system for analysis of nucleic acids: System for detection and/or analysis of nucleic acids using nanowires to detect covalent modification of nucleic acids.... Agent: Life Technologies Corporation C/o Intellevate

20090226892 - Nucleic acid analysis method: The present invention relates to a total system for nucleic acid analysis whereby the steps of extracting, amplifying, and detecting a nucleic acid can all be performed on a single solid support. Specifically, the present invention relates to a nucleic acid analysis method comprising adding a nucleic acid-containing specimen to... Agent: Nixon Peabody LLP - Patent Group

20090226911 - Reaction chamber having pre-stored reagents: Disclosed are preloaded analysis modules comprising reagents disposed within a barrier material capable of liberating the reagents, at a time advantageous to a reaction scheme, when exposed to certain activation conditions or reagents. Also disclosed are related methods for analyzing samples with such modules.... Agent: Woodcock Washburn LLP

20090226917 - Regulators of the non-genomic action of progesterone and methods of use: A progesterone regulator capable of modulating the non-genomic action of progesterone and methods of using the progesterone regulator are described. The progesterone regulator is useful for attenuating progesterone's inhibition of apoptosis and for the treatment of patients having a progesterone-responsive tissue disease such as endometriosis or cancer, particularly ovarian cancer,... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20090226897 - Saposin d and fam3c are biomarkers for alzheimer's disease: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's disease or non-Alzheimer's disease. The biomarkers can be detected by SELDI mass spectrometry.... Agent: Townsend And Townsend And Crew LLP

20090226903 - Thermal cycler: A thermal cycling device comprising a casing defining an air inlet and an air outlet, and a heater for heating air within the casing. A sample is located within the casing, and a selectively positionable member within the casing may be moved so as to either direct cool air from... Agent: Wolf Greenfield & Sacks, P.C.

20090226896 - Two component dna replicases with modified beta-subunit binding motifs, and uses thereof: The invention provides Pol III α mutants, and modified Pol III replicases comprising the same, and methods of using modified Pol III replicases for a variety of nucleic acid replication reactions.... Agent: King Spalding LLP

20090226930 - Beta cell antigen: The invention provides a purified human 38 kD beta cell antigen consisting of an intrinsic transmembrane protein of insulin secretory granules of beta cells lying in pancreatic islets of Langerhans, which protein contains an epitope recognized by T cell clone 1C6 (ECACC No. 1C6 90050301). The antigen may be used... Agent: Cooper & Dunham, LLP

20090226931 - Dual-target biosensor cell assays: A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type.... Agent: Corning Incorporated

20090226928 - Method and kit for detecting an analyte in a sample: The present invention provides devices, methods, and kits for the collection of a solid or semi-solid sample and analysis for the presence, absence, or quantity of an analyte. The invention provides an assay device having a housing containing a test element, a results window, and a docking area for receiving... Agent: Inverness Medical Innovations / Wsgr Wilson Sonsini Goodrich & Rosati, P.C.

20090226929 - Titinic ion channel, compositions and methods of use: The present invention provides methods and compositions related to a novel voltage sensitive protein comprising four transmembrane domains.... Agent: Ropes & Gray LLP

20090226932 - Novel g protein-coupled receptor: The present invention is directed to novel G protein-coupled receptors that are found predominantly in the dorsal root ganglia. The invention encompasses both the receptor proteins as well as nucleic acids encoding the proteins. In addition, the present invention is directed to methods and compositions which utilize the receptors.... Agent: Pepper Hamilton LLP

20090226935 - Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof: Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis or by specific binding partners, such as antibodies.... Agent: Foley And Lardner LLP Suite 500

20090226934 - Process for the detection of analytes: An improved process for the detection of analytes in a liquid, including pathogens and other toxic substances, using liquid crystal display technology comprising coating a test cell with one or more antibodies, flowing a test sample through the cell, rinsing the cell to remove any uncaptured analytes, introducing and aligning... Agent: Polsinelli Shughart PC

20090226933 - Quantification of fusion proteins and their activity from chromosomal translocation: The present invention concerns the detection of gene products resulting from chromosomal translocations, including fusion proteins comprising a first and second region. In particular, the fusion proteins are identified following subjecting a sample comprising the proteins to a bead comprising an antibody to a first region, followed by subjecting the... Agent: Fulbright & Jaworski, LLP

20090226936 - Tetrahydrofolate synthetase gene: By finding a novel tetrahydrofolate synthetase gene and a protein encoded by said gene, a method for identifying a compound which inhibits cell growth accelerating activity of said protein is provided, and a judging method, a preventing method and a treating method of colon cancer are provided. A DNA comprising... Agent: Sughrue-265550

20090226940 - Novel fluorescent dyes and uses thereof: The present invention relates to fluorescent dyes based on acridine derivatives and use of such dyes, for example, in biochemical and/or cell based assays. A preferred feature of some of the dyes described is their long fluorescence lifetimes and their use to label biological molecules.... Agent: Hoxie & Associates LLC

20090226941 - Detection of trichomonas: The present invention is directed to diagnostic devices and methods for detecting Trichomonas infections.... Agent: Dority & Manning, P.A.

20090226942 - Modified aerolysin and methods of use for treating lung cancer: Disclosed herein are lung cancer specific binding agents, as well as related amino acid and nucleic acid sequences. Methods of using such agents in the diagnosis and treatment of treat lung cancer are also disclosed. In an embodiment of the invention there is provided an antibody or fragment thereof comprising... Agent: National Research Council Of Canada 1200 Montreal Road

20090226943 - Non-heating detection method for dermatophyte: The present invention provides a method of detecting dermatophyte, including a step of extracting a dermatophyte component from a sample with a treatment liquid containing a non-ionic surfactant or a zwitterionic surfactant, and a kit for diagnosing dermatophyte infection, containing a treatment liquid comprising the above surfactant, and an antibody... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090226937 - Methods for the detection and monitoring of congestive heart failure: Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart failure can be of any etiology, such as systolic or diastolic heart failure, ischemic or non-ischemic cardiomyopathy.... Agent: Cantor Colburn, LLP

20090226938 - One-step enzymatic and amine detection technique: A technique for detecting the presence or quantity of an enzyme (or enzyme inhibitor) and/or an amine within a test sample is provided. For example, in one embodiment, a diagnostic test kit is employed that utilizes reactive complexes that each includes a substrate joined (e.g., covalently bonded, physically adsorbed, etc.)... Agent: Dority & Manning, P.A.

20090226939 - System and assay for detection of cardiac markers for assessing acute myocardial infarction: Assay systems and methods are provided for detecting a target antigen in a physiological fluid (e.g., blood, serum, or urine). The method includes linking via a first antibody a magnetic microparticle to the target antigen in the physiological fluid; linking via a second antibody a glucose molecule to the target... Agent: Sutherland Asbill & Brennan LLP

20090226944 - Method for measuring triglyceride in low-density lipoprotein and kit for measurement: s

20090226945 - Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same: A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins with an enzyme, the substrate of which is free cholesterol, optionally together with a reaction accelerator; a method for quantitating cholesterol in specific lipoproteins by... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090226946 - Thermal denaturation screening assay to identify candidate compounds for prevention and treatment of parkinson's disease: The invention provides highthroughput screening assays to identify agents useful for treatment of Parkinson's Disease. In one embodiment the assay includes exposing a plurality of test samples, each containing a test compound and parkin protein, to thermal destabilization conditions and determining parkin ligase activity in the test samples relative to... Agent: Townsend And Townsend And Crew, LLP

20090226947 - Non-invasive enzyme screen for tissue remodelling-associated conditions: Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of metastatic cancer by the identification of high molecular... Agent: Wolf Greenfield & Sacks, P.C.

20090226948 - Enzyme-based time temperature indicator: The present invention relates to a time temperature indicator for indicating temperature change over time, comprising an immobilized enzyme and a substrate of the enzyme, wherein the reaction of the substrate catalyzed by the enzyme produces a reaction product in a time and temperature dependent manner and wherein the formation... Agent: Joann Villamizar Ciba Corporation/patent Department

20090226949 - Single-cell biosensor for the measurement of gpcr ligands in a test sample: The present invention is related to the detection of GPCR ligands in a test sample by using a single cell biosensor expressing a GPCR. Preferably, the test sample is derived from a biological or environmental sample. This invention may be used to detect the presence of a disease or to... Agent: Morgan, Lewis & Bockius, LLP

20090226951 - Analysis method of mixed liquid in waste water treatment: [Solving means] An oxygen consumption rate kx=KLa·(DOhf−highDOx) of a last block (block x) containing only one BOD component is first obtained by using the above approximate expression of a dissolved oxygen-concentration change curve, Δtx=tx−tx−1, and BODx=kx·Δtx; kx−1 of a block which contains two BOD components and which is second to... Agent: Birch Stewart Kolasch & Birch

20090226950 - Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor: A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090226955 - Immortalized retinal pigmented epithelial cells: The present invention provides isolated cultures of immortalized retinal pigmented epithelial cells. The cells retain one or more of the in vivo characteristics of non-immortalized retinal pigmented epithelial cells, including, for example, cobblestone morphology, polarization, the presence and/or expression of one or more protein markers, and a metabolic pattern typical... Agent: Venable LLP

20090226954 - Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits: The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target... Agent: Enzo Biochem, Inc.

20090226956 - Runx-mediated action of nuclear receptors and utilities thereof: The present invention discloses methods of identifying candidate compounds for modulating the activity of Runx2 or Runx1 through inhibition by ERα or AR in a cell, and using such compounds for treating bone diseases and cancer. Also disclosed are isolated polypeptides having fragments of a Runx2 protein or an AR... Agent: Hogan & Hartson L.L.P.

20090226952 - Screening method for compounds with anaesthetic property: There is provided an in vitro screening method for compounds with anaesthetic property, which can distinguish anaesthetics from analgesics and relies on observing the ability of compounds to prolong the duration of transient working neuronal assemblies as may be generated, for example, in in vitro hippocampal slices and observed by... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090226953 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Genentech, Inc.

20090226957 - Process and device for separating biological particles contained in a fluid by means of filtration: The invention relates to a method of separating biological particles from the liquid containing same for purification, analysis and optionally diagnostic purposes. The inventive method comprises at least one step involving vertical filtration through a filter having a porosity that is adapted to the type of biological particles to be... Agent: Stites & Harbison PLLC

20090226958 - Set of standards and method of production: A set of 10 or more standards containing a defined number of particles from 1000 to 1,000,000 wherein the defined number of particles is within a degree of error of 10% or less between each standard of the set.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090226959 - Production of modified glycoproteins having multiple antennary structures: The present invention relates to eukaryotic host cells, especially lower eukaryotic host cells, having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar and sugar nucleotide transporters to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The process provides an... Agent: Merck And Co., Inc

20090226968 - Engineering intracellular sialylation pathways: Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20090226960 - Method for generating tethered proteins: The present invention relates to a novel method of generating tethered extracellular or intracellular domains of transmembrane proteins using expression vectors. The invention also provides the expression vectors for use in the world.... Agent: King & Spalding LLP

20090226963 - Method for production of protein having non-natural type amino acid integrated therein: This invention provides a method for producing proteins into which non-natural amino acids have been incorporated at desired positions involving the use of either prokaryote-derived or eukaryote-type aaRS* and prokaryotic cells or eukaryote-type as host cells, the method comprising steps of: (a) introducing genes encoding prokaryote-derived aminoacyl tRNA synthetase mutants... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090226962 - Microbial strains and processes for the manufacture of biomaterials: DNA constructs and genetically engineered microbial strains constructed using these DNA constructs, which produce a nuclease enzyme with specificity for DNA and/or RNA, are provided. These strains secrete nuclease into the periplasm or growth medium in an amount effective to enhance productivity and/or recovery of polymer, and are particularly suited... Agent: Pabst Patent Group LLP

20090226961 - Mutant alpha-amylases: A

20090226964 - Polymyxin synthetase and gene cluster thereof: The present invention relates to a polymyxin synthetase isolated from Gram-positive Paenibacillus sp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated from Paenibacillus polymyxa E681, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the gene cluster. The polymyxin... Agent: Greenlee Winner And Sullivan P C

20090226966 - Polypeptide having activity of aminoacyl-trna synthetase and use thereof: A polypeptide according to the present invention includes: an altered polypeptide obtained by altering an ArgRS, a CysRS, a MetRS, a GlnRS, a GluRS, a LysRS, a TyrRS, or a TrpRS so that an unnatural amino acid is recognized; and an editing polypeptide derived from a PheRS, a LeuRS, an... Agent: Edwards Angell Palmer & Dodge LLP

20090226967 - Saponin-decomposing enzyme, gene thereof and large-scale production system for producing soyasapogenol b: The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce soyasapogenol B, a polynucleotide encoding such a protein, and a method of producing soyasapogenol B on a large scale using the same. A protein... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090226965 - Vaccine for preventing and treating porcine progressive atrophic rhinitis and making process thereof: The present invention relates to an animal vaccine directed to progressive atrophic rhinitis (PAR), comprising at least two fragments of recombinant subunit Pasteurella multocida toxins (rsPMT) capable of eliciting the production of antibodies against Pasteurella multocida associated with PAR, and to a method for producing the animal vaccine of the... Agent: Charles E. Baxley, Esquire

20090226970 - Soluble fusion proteins comprising heterologous polypeptides: A soluble fusion protein is disclosed. The soluble fusion protein comprises at least one soluble polypeptide and a heterologous polypeptide being fused thereto, the heterologous polypeptide being normally insoluble and/or suboptimally expressed when expressed in a cell, wherein the at least one soluble polypeptide has an amino acid sequence at... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090226969 - Spider silk proteins and methods for producing spider silk proteins: The invention provides an isolated major ampullate spidroin protein, which consists of from 150 to 420 amino acid residues and is defined by the formula KEP-CT. KEP is a repetitive, N-terminally derived protein fragment having from 80 to 300 amino acid residues. CT is a C-terminally derived protein fragment having... Agent: Birch Stewart Kolasch & Birch

20090226971 - Portable rapid microfluidic thermal cycler for extremely fast nucleic acid amplification: A portable apparatus for thermal cycling a material to be thermal cycled includes a portable microfluidic-compatible platform, a microfluidic heat exchanger carried by the portable microfluidic-compatible platform; a porous medium in the microfluidic heat exchanger; a microfluidic thermal cycling chamber containing the material to be thermal cycled, the microfluidic thermal... Agent: Lawrence Livermore National Security, LLC

20090226972 - Rapid microfluidic thermal cycler for nucleic acid amplification: A system for thermal cycling a material to be thermal cycled including a microfluidic heat exchanger; a porous medium in the microfluidic heat exchanger; a microfluidic thermal cycling chamber containing the material to be thermal cycled, the microfluidic thermal cycling chamber operatively connected to the microfluidic heat exchanger; a working... Agent: Lawrence Livermore National Security, LLC

20090226973 - Reagents and methods for improving reproducibility and reducing mispriming in pcr amplification: An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and a stabilized stem terminus. The additive improves PCR amplifications, including LATE-PCR amplifications when added to initial amplification reaction mixtures. It can be... Agent: Foley And Lardner LLP Suite 500

20090226974 - Sample processing for nucleic acid amplification: Methods are described for the processing of biological samples for direct use in nucleic acid amplification without extracting or isolating the nucleic acids from the sample. In preferred embodiments, the processed sample provides the nucleic acid template in PCR-based assays.... Agent: Foley & Lardner LLP

20090226976 - Methods for dynamic vector assembly of dna cloning vector plasmids: A method for using cloning vector plasmids to produce DNA molecules, such as transgenes, in a single cloning step. The transgenes can be used for the purpose of gene expression or analysis of gene expression. The plasmid cloning vectors are engineered to minimize the amount of manipulation of DNA fragment... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090226975 - Constant cluster seeding: The invention provides methods for controlling the density of different molecular species on the surface of a solid support. A first mixture of different molecular species is attached to a solid support under conditions to attach each species at a desired density, thereby producing a derivatized support having attached capture... Agent: Illumina, Inc. Legal Department

20090226891 - Encoded solid supports for biological processing and assays using same: Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20090226977 - Mutant strains of pseudomonas fluorescens and variants thereof, methods for their production, and uses thereof in alginate production: It is described biologically pure bacterial cultures of mutant strains of Pseudomonas fluorescens, which produces large amounts of alginate. The alginate may contain a certain determined content of mannuronate and guluronate residues, possible presence and determined level of acetyl groups in the alginate, and a desired molecular weight of the... Agent: Pepper Hamilton LLP

20090226979 - Method for hydrolysis of biomass in pulping spent liquor: A method for the hydrolysis of cellulosic materials using spent liquor. The spent liquor is derived from a pulping operation or is hydrolyzate from another cellulosic biomass process. The process can be implemented in a batch or semi continuous or continuous process. The hydrolyzate is fermented to a useful product... Agent: American Process Inc Steve Rutherford

20090226978 - Thermal and acid tolerant beta-xylosidases, genes encoding, related organisms, and methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof are provided. Further provided are methods of at least partially degrading xylotriose and/or xylobiose using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof.... Agent: Traskbritt / Battelle Energy Alliance, LLC

20090226980 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the kefb gene: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the kefB gene.... Agent: Cermak & Kenealy LLP Acs LLC

20090226981 - L-glutamic acid-producing microorganism and a method for producing l-glutamic acid: L-Glutamic acid is produced by culturing a microorganism in which an expression of L-glutamic acid-export gene, a yhfK gene, is enhanced or overexpressed, in a medium to produce and cause accumulation of L-glutamic acid in the medium, and collecting L-glutamic acid from the medium.... Agent: Cermak & Kenealy LLP Acs LLC

20090226984 - L-cysteine producing bacterium and a method for producing l-cysteine: The present invention describes a bacterium belonging to the family Enterobacteriaceae which has L-cysteine-producing ability and has been modified to decrease the activity of a protein encoded by the d0191 gene. This bacterium is cultured in a medium, and L-cysteine, L-cystine, derivatives thereof, or a mixture thereof is collected from... Agent: Cermak & Kenealy LLP Acs LLC

20090226982 - L-cysteine producing microorganism and method for producing l-cysteine: L-Cysteine is produced by culturing a microorganism having an ability to produce L-cysteine and modified so that expression of emrAB, emrKY, yojIH, acrEF, bcr, or cusA gene should be enhanced in a medium to produce and accumulate L-cysteine in the medium and collecting the L-cysteine from the medium. Genes coding... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090226983 - L-cysteine-producing bacterium and a method for producing l-cysteine: The present invention provides a bacterium belonging to the family Enterobacteriaceae which has L-cysteine-producing ability and has been modified to decrease the activity of the protein encoded by the yhaM gene. This bacterium is cultured in a medium, and L-cysteine, L-cystine, their derivatives, or a mixture thereof is collected from... Agent: Cermak & Kenealy LLP Acs LLC

20090226985 - Process for the preparation of l-amino acids using strains of the enterobacteriaceae family: The invention relates to a process for the preparation of L-amino acids, in particular L-threonine.... Agent: Smith, Gambrell & Russell

20090226986 - Production of coenzyme q-10: The present invention provides improved processes for the preparation of Coenzyme Q-10 (CoQ10) by fermentation of microorganisms of the genus Rhodobacter transformed with the mevalonate operon of Paracoccus zeaxanthinifaciens.... Agent: Stephen M. Haracz, Esq. Bryan Cave LLP

20090226987 - Desaturase genes, enzymes encoded thereby, and uses thereof: Disclosed are isolated polynucleotides encoding an omega-3 desaturase and a delta-12 desaturase, the enzymes encoded by the isolated polynucleotides, vectors containing the isolated polynucleotides, transgenic hosts that contain the isolated polynucleotides that express the enzymes encoded thereby, methods for producing the desaturase enzymes, and method of using the enzymes to... Agent: Ross Products Division Of Abbott Laboratories Department 108140-ds/1

20090226988 - Method for producing polymer: A method for producing a polymer including a chemical thioester exchange reaction for forming an acetyl-CoA by reacting an acetyl-thioester with CoA, a monomer-producing reaction for forming a (monomer precursor)-CoA derivative by reacting at least one monomer precursor compound with the acetyl-CoA and a polymerization reaction for forming the polymer... Agent: Quinn Emanuel Urquhart Oliver & Hedges, LLP Koda/androlia

20090226989 - Genetically modified yeast of the species issatchenkia orientalis and closely relates species, and fermentation processes using same: Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.... Agent: Gary C. Cohn, PLLC

20090226990 - Methods for the economical production of biofuel from biomass: Methods for producing a biofuel are provided. Also provided are biocatalysts that convert a feedstock to a biofuel.... Agent: Paul, Hastings, Janofsky & Walker LLP

20090226991 - Yeast organism producing isobutanol at a high yield: There is disclosed a method of producing isobutanol. In an embodiment, the method includes providing a microorganism transformed with an isobutanol producing pathway containing at least one exogenous gene. The microorganism is selected to produce isobutanol from a carbon source at a yield of at least 10 percent theoretical. The... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090226992 - Enhancement of microbial ethanol production: A thermophilic microorganism lacks lactate dehydrogenase activity and preferably contains an active pyruvate formate lyase pathway. The thermophilic microorganism contains a gene encoding an NAD-linked formate dehydrogenase. The gene encoding an NAD-linked formate dehydrogenase is preferably a codon optimised version of the gene encoding a thermostable NAD-linked formate dehydrogenase. DNA... Agent: Andrus, Sceales, Starke & Sawall, LLP

20090226993 - Novel strain and a novel process for ethanol production from lignocellulosic biomass at high temperature: The present invention relates to a novel thermophilic ethanol producing yeast strain, a microorganism, Kluyveromyces sp. IIPE453 MTCC 5314, classified as yeast, which exhibits growth and sugar fermentation at higher temperature range between 37° C. to 55° C. The novel yeast strain is capable of utilizing wide range of mono... Agent: Luedeka, Neely & Graham, P.C.

20090226994 - Method and device for acoustic manipulation of particles, cells and viruses: The present invention relates to a method and device for non-intrusively manipulating suspended particles and/or cells and/or viruses, which are supplied to a micro-chamber or to a micro-channel (46) of a substrate, said micro-chamber or micro-channel (46) having at least a bottom wall as well as lateral walls. At least... Agent: Breiner & Breiner, L.L.C.

20090226995 - Pancreatic cancer genes: The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20090226996 - Oxygen scavenger coating composition: A coating composition having an multicopper oxidase enzyme and an oxidizable substrate in combination with an organic binder polymer which may be dispersed or dissolved in a non-aqueous liquid vehicle.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090226997 - Oxygen scavenging composition: The composition of the present invention, combining multicopper oxidase enzyme, oxidizable substrate, and iron, exhibits a rate of oxygen scavenging that is in excess of that predicted from the rule of mixtures applied to the combination of enzyme/substrate and iron/substrate compositions that are known in the art.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090226998 - Novel bacillus thuringiensis crystal polypeptides, polynucleotides, and compositions thereof: The present invention provides insecticidal polypeptides related to shuffled Bacillus thuringiensis Cry1 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the polypeptides and nucleic acids of the invention to enhance resistance of plants to insect predation are encompassed.... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pioneer Hi-bred

20090226999 - Low-substrate-specific amino acid racemase and process for producing racemic amino acid: The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a process for producing a racemic amino acid which comprises allowing... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090227000 - Chimeric adenoviruses for use in cancer treatment: The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.... Agent: Banner & Witcoff, Ltd.

20090227001 - Fungal mixture and preparation thereof: The present invention provides a composition of Antrodia cinnamomea, a mixture of Antrodia cinnamomea, a fungal mixture and preparation thereof. In particular, the present invention can massively produce fungi in gel mediums.... Agent: Wpat, PC Intellectual Property Attorneys

20090227002 - Methods and compositions for the production of orthogonal trna-aminoacyl trna synthetase pairs: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.... Agent: Quine Intellectual Property Law Group, P.C.

20090227003 - Methods and systems for biomass recycling and energy production: The present invention comprises methods and systems for treating biomass wastes to result in usable byproducts. Biomass is treated to remove debris, transferred to microbial digester units, such as anaerobic and aerobic digesters, and the resultant solids and liquids are provided to an algae production unit. Algae are harvested and... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090227004 - Method of liberating bound oil present in stillage: A method for processing of byproducts in an ethanol production process is provided. The method includes applying a mixture of a microorganism to a stillage stream, metabolizing gums in the stillage stream using the mixture to release oil in the gums carried by the stillage stream and recovering the oil.... Agent: Dorsey & Whitney LLP Intellectual Property Department

20090227006 - Apparatus for performing nucleic acid analysis: The embodiments of the present invention are directed to an automatic apparatus (55), which is designed for performing nucleic acid analysis, optionally including sample preparation, with integrated disposable sample holding and processing devices (1), which devices (1) comprise a sample to be analyzed with the apparatus (55). The apparatus (55)... Agent: Roche Molecular Systems, Inc. Patent Law Department

20090227007 - Devices and methods for monitoring genomic dna of organisms: The invention provides an apparatus that can be used in methods of preparing, amplifying, detecting, and/or optionally selecting for further analysis the genomic material from an organism for the rapid detection and/or classification of an organism in a sample (e.g., screening for, identifying, quantifying, and/or optionally further analyzing, e.g., sequencing,... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090227005 - Methods for pathogen detection: The present disclosure relates to methods, systems, devices, and microfluidic chips that may be used for the detection of pathogens.... Agent: Searete LLC Clarence T. Tegreene

20090227008 - Culture apparatus: There is provided a culture apparatus which is capable of shortening a sterilization time and sterilizing the culture apparatus including a gas concentration measuring sensor, pipes connected to a gas concentration measuring device and every corner of a cultivating chamber. The culture apparatus includes a sterilizing gas generator 42 that... Agent: Kratz, Quintos & Hanson, LLP

20090227010 - Carbonic anhydrase having increased stability under high temperature conditions: The present invention relates to polynucleotide and polypeptide sequences of novel carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic anhydrase.... Agent: Ware Fressola Van Der Sluys & Adolphson, LLP

20090227013 - Early endosperm promoter eep2: This invention relates generally to the field of plant molecular biology. More specifically, this invention relates to methods and reagents for the temporally- and/or spatially-regulated expression of genes, particularly in plant seeds and related female reproductive tissue. Compositions comprise novel nucleotide sequences for a seed-preferred promoter known as eep2. A... Agent: Pioneer Hi-bred International, Inc.

20090227012 - Human cdr-grafted antibody and antibody fragment thereof: A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4... Agent: Sughrue-265550

20090227011 - Methods of purifying plasmid dna: Described herein are novel methods to purify plasmid DNA from host cells. After a standard lysis procedure that releases plasmid DNA from the host cells, two sequential precipitation procedures separate plasmid DNA from essentially all impurities of the host cells. An optional third precipitation procedure further polishes the plasmid DNA... Agent: Knobbe Martens Olson & Bear LLP

20090227009 - Selective terminal tagging of nucleic acids: Methods are provided for adding a terminal sequence tag to nucleic acid molecules for use in RNA or DNA amplification. The tag introduced may be used as a primer binding site for subsequent amplification of the DNA molecule and/or sequencing of the DNA molecule and therefore provides means for identification... Agent: Casimir Jones, S.c.

20090227014 - Novel isoforms of vascular endothelial cell growth inhibitor: This invention discloses two new VEGI isoforms named VEGI-192a and VEGI-192b consisting of 192 amino acid residues. These isoforms show endothelial cell-specific expression and share a C-terminal 151-residues segment with the previously described VEGI-174 and VEGI-251. Methods of using these isoforms of VEGI in diagnosing, screening agonist and antagonist of... Agent: Morrison & Foerster LLP

20090227015 - Novel short isoform of annexin a10 at chromosome 4q, termed annexin 10s (anxa 10s) and methods of use: ABSTRACT The present invention includes compositions including a novel short isoform of Annexin A10, termed Annexin 10s (ANXA10s) and methods of use. The compositions include nucleic acid molecules encoding ANXA10s, ANXA10s polypeptides, ANXA10s amino acid sequences and derivatives or modifications thereof. Included in these methods are the interrelation of the... Agent: Occhiuti Rohlicek & Tsao, LLP

20090227016 - Il-17 homologous polypeptides and therapeutic uses thereof: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide... Agent: Goodwin Procter LLP

20090227017 - Nucleic acids encoding receptor for il-17 homologous polypeptides and uses thereof: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Goodwin Procter LLP

20090227018 - Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction: Particular aspects of the present invention provide compositions and methods for modulating intracellular signal transduction, including modulation of at least one of membrane structure, membrane potential or membrane conductivity, membrane proteins or receptors, ion channels, and calcium dependant cellular messaging systems, comprising use of the inventive electrokinetically generated solutions to... Agent: Davis Wright Tremaine, LLP/seattle

20090227019 - Hematopoietic stem cell identification and isolation: The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48− HSCs, and CD244− HSCs. The present invention also relates to purified cell samples with enriched CD150+ HSCs,... Agent: Casimir Jones, S.c.

20090227020 - Immunogenic peptides: The invention provides relatively short immunogenic peptides, and biologically active variants thereof, associated with leukemia which elicit an immune response. Nucleic acids encoding the immunogenic peptides and antibodies specific for the peptides are also provided. The immunogenic peptides can be included in pharmaceutical compositions, such as cancer vaccines, and used... Agent: Foley & Lardner LLP

20090227022 - Growth factor homolog zvegf4: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the... Agent: Townsend And Townsend And Crew LLP

20090227021 - Purified mammalian ctla-8 antigens and related reagents: CTLA-8 antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20090227023 - De-differentiation of astrocytes into neural stem cell using shh: Disclosed are a composition and a method for inducing the de-differentiation of astrocytes into neural stem cells using Shh. The de-differentiated neural stem cells have the ability to differentiate into astrocytes, neurons, and oligodendrocytes.... Agent: Bozicevic, Field & Francis LLP

20090227024 - Modified polysaccharide for cell culture and release: Hydrophobically modified polysaccharide compositions, articles incorporating the compositions, and methods for cell culture, automatic release of cells, and release of cell culture coating from a substrate or the cell culture articles incorporating the coating compositions, as defined herein.... Agent: Corning Incorporated

20090227025 - Ex vivo human lung/immune system model using tissue engineering for studying microbial pathogens with lung tropism: A method for studying scaffold-based tissue engineering approaches in combination with the use of progenitor or stem cells to generate new lung tissue in an in vitro system. The engineered tissue system of this invention is used to monitor lung and immune system exposure of pathogen and/or toxins. The method... Agent: Robert W Strozier, P.l.l.c

20090227026 - Tissue engineering scaffolds: The present invention relates to tissue engineering scaffolds (TE scaffolds) that mimic the biomechanical behavior of native blood vessels, tissue engineered blood vessels (TEBVs) derived from the TE scaffolds, and methods of making and using the TE scaffolds and TEBVs.... Agent: Goodwin Procter LLP Attn: Patent Administrator

20090227027 - Coated cell culture surfaces and methods thereof: A composition for use, for example, in cell culture surface modification and in cell culture articles, as defined herein. Also disclosed are methods of making the compositions and articles, and methods of using the compositions and articles, as defined herein.... Agent: Corning Incorporated

20090227028 - Biological control of pathogenicity in microbes that use alpha, beta unsaturated fatty acid signal molecules: DSF-based microbial pathogens may be controlled by certain methods and compositions. A method of controlling diseases caused in a host organism by pathogenic microbial expression of α,β unsaturated fatty acid signal (DSF) molecules involves inoculating the host organism with a non-pathogenic microbe that disrupts α,β unsaturated fatty acid signal molecule-mediated... Agent: Weaver Austin Villeneuve & Sampson LLP

20090227029 - Process for chromosomal engineering using a novel dna repair system: This invention relates to chromosomal engineering via DNA repair process. The process of the invention comprises the steps of: 1) submitting at least one source of biological activity, e.g. Deinococcus radiodurans, to radiation, desiccation and/or chemical treatment liable to damage the DNA, so as to substantially shatter its chromosomes into... Agent: Nixon & Vanderhye, PC

20090227030 - Adeno-associated virus (aav) serotype 8 sequences, vectors containing same, and uses therefor: Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles.... Agent: Howson & Howson LLP

20090227031 - Cells for adenovirus vector and protein production: The present invention relates to a novel cell line for adenovirus (Ad) and protein production that does not eliminate the overlap between the cell-line and vector sequences, but represses undesirable homologous recombination events or their effects by the use of a large non-homologous spacer element(s).... Agent: Frommer Lawrence & Haug

20090227032 - Nuclear reprogramming factor and induced pluripotent stem cells: The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including... Agent: Greenblum & Bernstein, P.L.C

  
09/03/2009 > patent applications in patent subcategories. class, title,number

20090220933 - Detection of fetal cells from maternal blood: The present application relates to methods for identification of foetal cells and generation and isolation of binding members recognising foetal cells. Said methods may further be used for other purposes relating to characterisation of biological samples and biological antigens. The methods are characterised by the applicability in situations where the... Agent: Davis Wright Tremaine LLP - San Francisco

20090220932 - Device and method for combined microfluidic-micromagnetic separation of material in continuous flow: A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps. A microfabricated high-gradient magnetic field concentrator (HGMC) is integrated at... Agent: David S. Resnick

20090220931 - Functional in vitro immunoassay: The invention relates to a method for the in vitro investigation of the effect of substances in in vivo processes and an in vitro detection method for the identification of immunomodulating compounds and/or the detection of the effect of immunomodulating compounds and the identification of apoptosis-inducing and/or necrosis-inducing compounds mediated... Agent: Ursula B. Day, Esq.

20090220930 - Time varying electromagnetic force sleeve for the expansion of cells and method of using the same: A time varying electromagnetic force sleeve wherein the time varying electromagnetic force sleeve comprises a time varying electromagnetic force source operatively connected to an electrically conductive coil that can removably receive a culture container. The present invention also relates to a method for cell expansion comprising providing a time varying... Agent: Ladas & Parry LLP

20090220935 - Apparatus and method for dissolved oxygen control in parallel integrated bioreactor array: Parallel, integrated bioreactor. The bioreactor includes a plurality of growth chambers, each growth chamber associated with a peristaltic oxygenating mixer and separated therefrom by a porous membrane. Each oxygenating mixture has a gas inlet and a gas outlet with the gas inlet in fluid communication with a gas reservoir. A... Agent: Choate, Hall & Stewart LLP

20090220934 - Methods and processes of controlling fermentation: The present invention relates to methods and processes for controlling fermentation. Two proportional feedback control loops are implemented in a cascade. One control loop is used to maintain the pH by adjusting the dissolved oxygen-stat setpoint. The other control loop is used to maintain the dissolved oxygen by regulating the... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20090220936 - Flow cytometry reagent system: A method of measuring cellular hemoglobin of a blood sample includes mixing a blood sample with a permeation reagent, and incubating the sample mixture to permeate cellular membrane of red blood cells and to cause hemoglobin aggregation within the cells; adding a neutralization reagent to inhibit further reactions of the... Agent: Beckman Coulter, Inc. Mitchell E. Alter

20090220942 - Activated split-polypeptides and methods for their production and use: The present invention relates to a method to produce activated split-polypeptide fragments that on reconstitution immediately forms an active protein. The method relate to real-time protein complementation. Also encompassed in the invention is a method to split and produce split-fluorescent proteins in an active state which produce a fluorescent signal... Agent: Ronald I. Eisenstein

20090220946 - Adenovirus status as a predictor of body composition change, disease status, and treatment outcomes: Infection with obesifying adenoviruses in animals and humans may be used to predict changes in body weight and disease status. More particularly, infection with certain adenoviruses, such as adenovirus type 36 (Ad-36) and adenovirus type 37 (Ad-37) may cause removal of the normal equilibrium factors that control fat cell metabolism... Agent: Townsend And Townsend And Crew, LLP

20090220937 - Compositions for use in identification of adventitious viruses: The present invention provides compositions, kits and methods for rapid identification and quantification of adventitious contaminant viruses by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.

20090220941 - Compositions for- detecting of influenza viruses and kits and methods using same: An isolated composition-of-matter comprising a sialic acid bound to a sialic acid binding domain of a polypeptide is provided. Uses thereof and kits comprising same are also provided.... Agent: Cantor Colburn, LLP

20090220943 - Hcv genotyping and phenotyping: The present invention includes methods of genotyping and phenotyping HCV. In one embodiment, the methods of the invention can be used to determine whether a HCV isolate is resistant to an antiviral drug. The invention also includes primers for amplifying a HCV NS3 region and kits.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090220945 - Hpv e6, e7 mrna assay and methods of use thereof: Provided is an HPV E6, E7 mRNA assay, referenced herein as the “In Cell HPV Assay,” that is capable of sensitive and specific detection of normal cervical cells undergoing malignant transformation as well as abnormal cervical cells with pre-malignant or malignant lesions. The In Cell HPV Assay identifies HPV E6,... Agent: Bozicevic, Field & Francis LLP

20090220940 - Method for testing the integrity of membranes: A method for evaluating the integrity of microfiltration, ultrafiltration and nanofiltration membranes, which method comprises passing a liquid that contains a substantially mono-dispersed population of nano-probes through said membrane to form a permeate and testing said permeate for the presence of said nano-probes, wherein the non-detection of said nano-probes in... Agent: Nixon & Vanderhye, PC

20090220944 - Method to measure and characterize microvesicles in the human body fluids: This disclosure provides a method to capture, detect, characterize and quantify human exosomes in small volumes of human body fluids by using a sandwich ELISA test. This method allows a full characterization of an exosome preparation, thus providing a tool to distinguish a disease-related condition from a healthy state, by... Agent: Dodds & Associates

20090220939 - Methods for determing resistance or susceptibility to hi entry inhibitors: The invention provides a method for determining whether a human immunodeficiency virus is likely to be more resistant to a viral entry inhibitor than a reference HIV. In certain aspects, the methods comprise comparing the length of one or more variable regions of an envelope protein of the HIV or... Agent: Jones Day

20090220938 - Viral nucleoprotein detection using an ion channel switch biosensor: The present invention provides a method of detecting viruses, such as respiratory-related viruses, in a sample with a sensitivity of at least 80%, and/or specificity of at least 90%, and/or with an accuracy of at least 90%. The method comprises contacting the sample with a biosensor. The present invention also... Agent: Howrey LLP-ca

20090220947 - Biomarkers for toxic algae: The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can... Agent: Attn: Maquita Wong The Hong Kong Polytechnic University

20090220983 - Cell-based methods for detecting and/or measuring bmp-12-related protein activity: The invention provides cell-based methods to detect and/or measure the BMP-12-related protein activity of a sample containing a BMP-12-related protein. The methods involve contacting a suitable cell with the sample, and measuring the expression level of at least one BMP-12-related-activity-marker. A dose-dependent increase(s) in the level(s) of the BMP-12-related-activity-markers is... Agent: Wyeth/finnegan Henderson, LLP

20090220952 - Compositions and methods for analyzing protein interactions: The present invention relates to compositions and methods for analyzing and modulating (e.g., enhancing or inhibiting) protein-protein interactions. In particular, compositions and methods of the present invention find use in identifying, reconstituting and characterizing protein-protein interactions, identifying binding subunits, and drug screening. The methods and compositions of the invention may... Agent: Casimir Jones, S.c.

20090220982 - Compositions and methods for determining nephrotoxicity: The present invention provides novel in vitro assays for determining the nephrotoxicity of a compound. These assays correlate well with in vivo nephrotoxicity and also provide high-throughput methods to screen multiple compounds for in vivo nephrotoxicity. In addition, the methods of the present invention may be adapted to screen for... Agent: Seed Intellectual Property Law Group PLLC

20090220981 - Compositions and methods for determining the presence of chlamydophila pneumoniae in a test sample: Oligonucleotides for use in determining the presence of Chlamydophila pneumoniae in a test sample. The oligonucleotides are incorporated into detection probes, capture probes, and amplification oligonucleotides, and can be used in various combinations thereof.... Agent: Gen Probe Incorporated

20090220961 - Fluorescent primer system for detection of nucleic acids (q priming): The present invention is directed to a self-quenching primer comprising; a fluorophore that can be quenched by guanine; an oligonucleotide sequence that forms a hairpin; an oligonucleotide that is a target specific sequence and; use in amplification reactions, particularly in polymerase chain reactions, during which the fluorophore is released thereby... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090220984 - Heat flow polymerase chain reaction systems and methods: Methods and systems for polymerase chain reactions (PCR) that are capable of detecting amplified DNA during or after the PCR process. The methods and systems may utilize DSC or DTA analysis techniques.... Agent: Patent Docket Department Armstrong Teasdale LLP

20090220953 - Identification of ancestral haplotypes and uses thereof: The present invention relates to the identification of haplospecific geometric elements (HGEs) in a multigene cluster comprising genes encoding complement control proteins. The present invention also relates to methods of performing genomic matching techniques (GMT) which enables the identification of HGEs of a duplicated region within a haplotype block. HGEs... Agent: Davis Wright Tremaine, LLP/seattle

20090220969 - Identifying and quantifying small rnas: One-step RT-PCR methods, compositions and kits for the detection and quantification of small RNAs in a sample are disclosed. The one-step RT-PCR approach involves polyadenylation of a small RNA followed by reverse transcription with a first primer containing a poly(T) sequence and at least two 3′ nucleotides complementary to the... Agent: The Eclipse Group LLP

20090220963 - Kit suitable for screening and establisment of optimal amplification condition in pcr constructed with dried-formulated pcr reagent and method for producing the same: The present invention relates to a kit for screening and establishing optimal amplification condition for individual PCR using a dried-formulated PCR reagent which is composed of different combinations of various components affecting PCR result, to provide a method for screening and establishment of optimal amplification in PCR constructed with a... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090220960 - Luciferase gene optimized for use in imaging of intracellular luminescence: The present invention provides a gene construct encoding pH insensitive luciferase for visualizing intracellular information, wherein an intracellular expression activity is higher compared with a gene construct of luciferase derived from a firefly.... Agent: Leydig Voit & Mayer, Ltd

20090220959 - Markers of definitive endoderm: Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.... Agent: Knobbe Martens Olson & Bear LLP

20090220957 - Membrane assay method: The present invention provides an assay method for a cell-containing body sample, said method comprising treating said sample under conditions whereby to cause cell lysis, preferably by means of a detergent; and subjecting the thus-generated lysed sample to conditions causing the cleavage of nucleic acid molecules. The invention additionally provides... Agent: Nixon Peabody, LLP

20090220958 - Method for diagnosing hepatic diseases and screening method of molecules for treatment of hepatic disease: The invention relates to a method for diagnosticating hepatic diseases consisting in measuring an apolipoprotein A4 expression in hepatic cells or tissues and in the circulation (blood, plasma, serum. A method for screening molecules for treating said diseases by bringing into contact said compounds with a mammal and for measuring... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20090220979 - Methods and apparatus for magnetic separation of cells: Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles... Agent: Peters Verny , L.L.P.

20090220968 - Methods and apparatus for near field irradiation: Irradiation methods and apparatus configured to deliver power, via electromagnetic fields at a variety of frequencies and power levels, in a localized fashion to a target area. In one example, an electromagnetic field generator is disposed on a substrate and configured to deliver power via electromagnetic energy to a thin... Agent: Wolf Greenfield & Sacks, P.C.

20090220974 - Methods and apparatus for the selection and/or processing of particles, in particular for the selective and/or optimised lysis of cells: Methods and apparatus for the selection or processing of particles sensitive to the application of an external stimulus, in which is produced, by applying the external stimulus, the rupture/lysis of at least one selected particle or the fusion of first and second selected particles, by means of the organisation of... Agent: Venable LLP

20090220955 - Methods and composition to generate unique sequence dna probes labeling of dna probes and the use of these probes: The invention relates generally to the field of identification of DNA sequences, genes or chromosomes. Methods and composition to obtain Unique Sequence DNA probes are provided. Composition comprises of any double stranded DNA containing Unique Sequences from which the repetitive sequences are eliminated according to the method described in this... Agent: Philip S. Johnson Johnson & Johnson

20090220951 - Methods and compositions for classifying bacillus bacteria: A method of classifying a Bacillus bacterium is provided. In certain embodiments, the method includes proteotyping a Bacillus bacterium by analyzing a nucleic acid encoding an SspE protein of the Bacillus bacterium.... Agent: Bozicevic, Field & Francis LLP

20090220948 - Methods and device for transmitting, enclosing and analysing fluid samples: A microfluidic device for analysing a fluid sample comprises at least one sample transmission channel; at least one multi-functional channel; and at least one reactor module which provides a fluid connection between the sample transmission channel and the multi-functional channel. Each reactor module comprises at least one reaction chamber, having... Agent: Thelen Reid Brown Raysman & Steiner LLP

20090220978 - Methods for detection and quantification of analytes in complex mixtures: The invention provides a diverse population of uniquely labeled probes, containing about thirty or more target specific nucleic acid probes each attached to a unique label bound to a nucleic acid. Also provided is a method of producing a population of uniquely labeled nucleic acid probes. The method consists of... Agent: Seed Intellectual Property Law Group PLLC

20090220964 - Methods for diagnosing and treating cancers via manipulations of a...pathway: Methods for diagnosing, treating, and screening for cancer based on manipulations of a newly discovered pVHL dependent, non-degradative ubiquitylation pathway of Rpb1. In particular, methods comprising the use of biomarkers implicating the pathway, and promoters of either or both of P1465 hydroxylation and CTD Ser-5 phosphorylation of Rpb1. Specifically, the... Agent: Dinsmore & Shohl LLP

20090220965 - Methods for prognosing the recurrence of gastrointestinal and other cancers using the shc proteins: The invention relates to methods for prognosing the recurrence of gastrointestinal and other cancers using tyrosine phosphorylated Shc (PY-Shc) and/or p66-Shc.... Agent: Sutherland Asbill & Brennan LLP

20090220954 - Methods of diagnosing cardiovascular disease: Methods are disclosed for diagnosing increased risk of cardiovascular disease in a subject.... Agent: Fish & Richardson PC

20090220962 - Microginin producing proteins and nucleic acids encoding a microginin gene cluster as well as methods for creating novel microginins: The invention provides for nucleic acid molecules enabling the synthesis of microginin and microginin analogues. The invention also provides for methods for identifying microginins as well creating microginins which may not be found in nature.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090220970 - Molecular toxicology modeling: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090220949 - Mutations associated with the long qt syndrome and diagnostic use thereof: The present invention is based on the identification of new mutations in KCNQ1 (also termed KvLQTI), KCNH2 (also termed HERG), SCN5A, KCNE1 (also termed minK), KCNE2 (also termed MiRP) genes that encode ionic channels involved in cardiac electrical activity and are potentially responsible for the Long QT Syndrome. According to... Agent: Clark & Elbing LLP

20090220977 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses: The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the... Agent: Millennium Pharmaceuticals, Inc.

20090220973 - Obesity and body fat distribution: Described are methods for predicting and diagnosing genetically-based obesity and body fat distribution, and for identifying compounds for the treatment and prevention of obesity.... Agent: Fish & Richardson PC

20090220956 - Prediction of local recurrence of breast cancer: The invention relates to the field of medicine, in particular to cancer, more specifically breast cancer, most specifically to a method to predict the local recurrence of breast cancer after breast conserving therapy. It has been demonstrated that a classification on basis of the similarity of the gene expression profile... Agent: Traskbritt, P.C.

20090220972 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 49 to 51 or a combination of at least two of... Agent: Fitzpatrick Cella Harper & Scinto

20090220985 - Rapid efficacy assessment method for lung cancer therapy: The present invention discloses a method for rapid assessment of lung cancer therapy efficacy in a few days instead of weeks by conventional imaging methods. This method can also be used to detect relapse of the cancer and to improve the current TNM cancer staging method for more accurate prognosis.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090220950 - Simultaneous quantification of nucleic acids in diseased cells: Processes and methods for the simultaneous quantification of nucleic acids in diseased cells that are based on real-time PCR are provided. The real-time PCR protocol is an excellent tool for reliable quantification of in vitro drug screening and evaluation protocols to determine the efficacy of potential anti-viral agents. Quantification using... Agent: Merchant & Gould PC

20090220967 - Systemic carnitine deficiency gene and uses thereof: The gene responsible for systemic carnitine deficiency was found to be the OCTN2 gene involved in the transportation of organic cations. This invention enables tests for this disease by detecting whether or not the OCTN2 gene has a mutation. Furthermore, systemic carnitine deficiency can be treated using the normal OCTN2... Agent: Fish & Richardson PC

20090220976 - Test method for malt lymphomas and kit therefor: An object of the present invention is to provide a test method for MALT lymphomas for providing genetic diagnosis data which can be used for the diagnosis of MALT lymphomas, identification of disease type, and prediction of progression of pathological conditions and onset thereof and a kit for implementing the... Agent: The Webb Law Firm, P.C.

20090220966 - Thermocycler and sample port: The invention relates to continuous flow systems, in particular thermocyclers for the automated and continuous cycling of fluid between a plurality of temperature zones in the amplification of nucleic acids. The invention also relates to an improved sample port for introducing a volume of a liquid sample into a continuous... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20090220971 - Treatment response in generalized social phobia: This invention generally pertains to the field of psychiatry. In particular, this invention relates to, inter alia, the discovery that a subject's serotonin transporter gene promoter polymorphism genotype can be used to determine the subject's response to certain drug therapies.... Agent: Fenwick & West LLP

20090220980 - Use of methylation status of mint loci and tumor-related genes as a marker for melanoma and breast cancer: The invention relates to a method of detecting melanoma or breast cancer using DNA methylation in MINT17, MINT31, or the promoter region of WIF1, TFPI2, RASSF1A, SOCS1, GATA4, or RARβ2 as a biomarker. Also disclosed are methods of using the biomarker for determining the cancer status and predicting the outcome... Agent: Hogan & Hartson L.L.P.

20090220975 - Use of protein satb2 as a marker for colorectal cancer: The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for this cancer type.... Agent: Birch Stewart Kolasch & Birch

20090220986 - Assessing non-alcoholic fatty liver disease: The document provides methods and materials related to assessing NAFLD in a mammal. For example, methods and materials for determining whether or not a mammal has an NAFLD are provided. In addition, methods and materials for determining whether a mammal with an NAFLD has a severe or mild form of... Agent: Fish & Richardson P.C.

20090220987 - Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays: The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte in a sample in which intramolecularly, covalently cross-linked proteins are used as binding partners, and it further... Agent: Barnes & Thornburg LLP (roche)

20090220988 - Method of revealing a biological process using a fret measurement: e

20090220989 - Particle-based analyte characterization: Methods for assaying a sample for an analyte are provided. In various embodiments, the methods comprise contacting a sample suspected of containing the analyte with a non-uniform particle comprising a capture molecule, and further contacting the particle with a detection moiety comprising a label that permits detection of the analyte... Agent: Bio Technology Law Group C/o Portfolioip

20090220999 - Antibodies immunoreactive with mutant 5-enolpyruvlshikimate-3-phosphate synthase: Antibodies immunoreactive to double mutant EPSPS are provided, and in an embodiment the double mutant EPSPS is one in which the wild-type EPSPS is substituted at residue 102 with isoleucine and at residue 106 with serine. Also provided are hybridomas producing the antibodies, as well as methods of making and... Agent: Patricia A. Sweeney

20090220996 - In vitro assay methods for classifying embryotoxicity of compounds: The present disclosure provides methods useful for screening compounds and/or compositions, for example potential drug candidates. The results of the screening assays correlate to the effects of the compounds on the molecular and/or cellular level of the human body. Also disclosed are screening assays utilizing human embryonic stem cells RELICELL®hES... Agent: Vinson & Elkins, L.L.P.

20090221001 - Methods for identifying compounds that modulate the t1r1/t1r3 umami taste receptor: Methods for identifying compounds that modulate the T1R1/T1R3 umami taste receptors are provided. These methods comprise screening for compounds that compete with lactisole for binding to and/or inhibiting the T1R1/T1R3 umami taste receptor.... Agent: Hunton & Williams LLP Intellectual Property Department

20090221000 - Methods of quantifying taste of compounds for food or beverages: Methods of quantifying the taste of compounds for food and beverages are provided. These methods comprise contacting the compounds with an isolated heteromeric receptor comprising at least one T1R2 polypeptide and at least one T1R3 polypeptide.... Agent: Hunton & Williams LLP Intellectual Property Department

20090221002 - Methods of quantifying taste of compounds for food or beverages: Methods of quantifying the taste of compounds for food and beverages are provided. These methods comprise contacting the compounds with an isolated heteromeric receptor comprising at least one T1R1 polypeptide and at least one T1R3 polypeptide.... Agent: Hunton & Williams LLP Intellectual Property Department

20090220995 - Multiple administrations of umbilicus derived cells: A method to determine the optimal administration protocol of allogeneic donor tissue to treat a disease in a human, using an animal model of human disease.... Agent: Philip S. Johnson Johnson & Johnson

20090220998 - Platelet aggregation assays: The present invention provides methods of determining platelet aggregation, methods of determining susceptibility to clotting upon administration of a CD40L-binding moiety, and kits related thereto.... Agent: Ropes & Gray LLP

20090221003 - Procedure for the generation of a high producer cell line for the expression of a recombinant anti-cd34 antibody: The present invention relates to cell capture assay for the selection of a high producer cell line expressing anti-CD34 antibodies that recognize the CD34 membrane-protein in the cell membrane. The monoclonal antibody secreted by the hybridoma cell line 9C5/9069 binds to human CD34 and is used to isolate stem cells.... Agent: Baxter Healthcare Corporation

20090220997 - Stimulating g protein-coupled receptors: This document provides methods and materials related to activating GPCRs. For example, methods and materials for activating GPCRs present on cells (e.g., human cell) as well as methods and materials for identifying GPCR agonists are provided.... Agent: Fish & Richardson P.C.

20090221004 - Caspase-cleavage anti-keratin antibodies for detection of apoptosis: The present invention relates to the field of detecting and quantifying apoptosis. In one aspect, the invention is directed to an isolated monoclonal or polyclonal antibody that specifically recognizes caspase-generated products of K18 or K19 but does not react with intact K18 or K19. The antibody typically reacts with the... Agent: 212 Consulting, Inc.

20090221005 - Method for detecting antigen specific or mitogen-activated t cells: The present invention comprises a method for the quantitative or qualitative detection of antigen-specific CD4+ T cells and/or CD8+ T cells in a subject, said method comprising quantitatively or qualitatively detecting the expression of cell surface marker CD25 and one or more of cell surface markers CD134 and CD137 in... Agent: Sheridan Ross PC

20090220990 - Method and kit for detecting condition in patient with disturbance of consciousness: A method for detecting a condition in a patient with disturbance of consciousness, by analyzing an amount and/or activity of a von Willebrand factor-cleaving protease, and a kit for detecting a condition in a patient with disturbance of consciousness, comprising an antibody or a fragment thereof which specifically binds to... Agent: Heslin Rothenberg Farley & Mesiti PC

20090220992 - Methods for the identification of lrrk2 interacting molecules and for the purification of lrrk2: The invention provides in a first aspect a method for the identification of an LRRK2 interacting compound, comprising the steps of providing a protein preparation containing LRRK2, contacting the protein preparation with indol ligand 91 immobilized on a solid support under conditions allowing the formation of an indol ligand 91-LRRK2... Agent: Clark & Elbing LLP

20090220991 - Reagents for the detection of protein phosphorylation in leukemia signaling pathways: The invention discloses nearly 480 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20090220993 - Method and compositions for specifically detecting physiologically acceptable polymer molecules: The present invention relates to a method for determining the amount of a physiologically acceptable polymer molecule bound to a protein, an antibody or other composition being capable of specifically binding to a physiologically acceptable polymer molecule, and a kit containing said antibody or composition.... Agent: Marshall, Gerstein & Borun (baxter)

20090220994 - Methods for diagnosis of chronic prostatitis/chronic pelvic pain syndrome: The present invention relates to methods for diagnosis of chronic prostatitis/chronic pain pelvic syndrome (CP/CPPS). We have found specific biomarkers that are present in higher concentrations in patients that have chronic prostatitis/chronic pain pelvic syndrome (CP/CPPS) as compared to subjects that have no symptoms of CP/CPPS. In particular, uromodulin (THP),... Agent: David S. Resnick

20090221006 - Diagnosis, prevention and treatment of crohn's disease using the ompc antigen: The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.... Agent: Townsend And Townsend And Crew, LLP

20090221007 - Diagnosis, prevention and treatment of crohn's disease using the ompc antigen: The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.... Agent: Townsend And Townsend And Crew, LLP

20090221008 - Neutrokine-alpha and neutrokine-alpha splice variant: The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically... Agent: Leydig, Voit & Mayer Ltd.

20090221009 - Diagnostic method for disorders using copeptin: The use of copeptin as diagnostic marker for the determination of the release of vasopressin, especially in connection with disorders associated with non-physiological alterations of vasopressin release from the neurohypophysis, especially for detection and early detection, diagnosing and monitoring of the course of cardiovascular diseases, renal and pulmonary diseases as... Agent: Heslin Rothenberg Farley & Mesiti PC

20090221010 - Methods for prediction and prognosis of cancer, and monitoring cancer therapy: The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of VEGF-165 as a biomarker for multi-kinase inhibitors.... Agent: Leona L. Lauder

20090221011 - Coagulation test system: A test element for the determination of coagulation in a plasma or whole blood sample having a first surface (2a) and a second surface (4a) in a predetermined distance opposite from each other, said both surfaces being provided with two substantially equivalent patterns forming areas of high and low surface... Agent: Morgan Lewis & Bockius LLP

20090221012 - Method for detecting procoagulant phospholipid: The present invention relates to a method for determining the amount of procoagulant phospholipid in a sample, said method comprising steps (i) to (iii) performed in the following order: (i) forming an admixture of the sample and a substrate plasma which has been rendered free or substantially free of procoagulant... Agent: Sughrue Mion, PLLC

20090221014 - Enzymatic biosensors with enhanced activity retention for detection of organic compounds: Enzymatic biosensors and methods of producing distal tips for biosensor transducers for use in detecting one or more analytes selected from organic compounds susceptible to dehalogenation, organic compounds susceptible to oxygenation, organic compounds susceptible to deamination, organosulfate compounds susceptible to hydrolysis, and organophosphate compounds susceptible to hydrolysis are disclosed herein,... Agent: Lathrop & Gage LLP

20090221013 - Method for quantifying living coliform microorganisms in a water sample: The invention relates to a method of rapidly quantifying living coliform microorganisms in a sample of water in which the microorganisms are put into contact with a fluorogenic substrate that is hydrolyzed in methylumbelliferone by an enzyme given off by the microorganisms. Methylumbelliferone is detected by the fluorescence that it... Agent: Townsend And Townsend And Crew, LLP

20090221015 - Detecting diastolic heart failure by protease and protease inhibitor plasma profiling: Disclosed herein are methods of detecting and predicting diastolic heart failure and predicting congestive heart failure comprise protease and protease inhibitor profiling.... Agent: Patent Correspondence Arnall Golden Gregory LLP

20090221016 - Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof: The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein concentrations. The present invention further discloses methods for generating crystals of the modified TACE protein in protein-ligand complexes with a number of inhibitors. In... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20090221017 - Anti-amyloid beta activity of intravenous immunoglobulin (ivig) in vitro: The present invention relates to a cell-based in vitro screening assay for identifying and selecting therapeutic agents that inhibit amyloid r-induced cytotoxicity.... Agent: Baxter Healthcare Corporation

20090221023 - Cell tray: A cell tray has a multi-dimensional array of cells in precise, equally spaced wells (cubicles or silos) containing medium of interest. The ordered cell array enables automated processing as well as simultaneous monitoring and analyzing of a large matrix of cells, biological fluids, chemicals and/or solid samples. The invention is... Agent: Virtual Law Partners LLP

20090221019 - Core-modified terpene trilactones from ginkgo biloba extract and biological evaluation thereof: Lactone-rings of ginkgolides are converted into the corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et3SiH/BF3Et2O producing a series of lactol-free ginkgolides. The present invention also relates to synthesis of hydroxyl-free, or hydroxyl-free and lactone-free, ginkgolides and bilobalides.... Agent: Cooper & Dunham, LLP

20090221021 - Distinction between bacterial meningitis and viral meningitis: The present invention relates to the field of the distinction between bacterial meningitis and viral meningitis. It relates in particular to an in vitro method for detecting the presence of bacterial meningitis, which comprises determining the concentration of procalcitonin present in a test blood sample and of proteins present in... Agent: Blank Rome LLP

20090221020 - Mass spectrometry assays for acetyltransferase/deacetylase activity: Provided are methods for determining the activity of proteins that modulate the acetylation state of a protein substrate. The methods may be used for determining both acetyltransferase activity and deacetylase activity. The methods utilize mass spectrometry for determining the acetylation state of a substrate peptide. The methods may also be... Agent: Ropes & Gray LLP

20090221018 - Procine circovirus type 2 vaccines: The present invention is based on the ORF3 gene of Porcine Circovirus Type 2 (PCV2) and the identification of tis apoptotic role. This discovery has led to the development of an attenuated live vaccine against PCV2.... Agent: K&l Gates LLP

20090221024 - T cell assays: The present invention relates to novel T cell assay methods, in particular where T cell responses to test antigens are increased by removal of regulatory T cells. Novel assays where the timing of incubation with antigens or other samples is varied in order to optimize detection of T cell responses... Agent: Brooks Kushman P.C.

20090221022 - Three dimensional cell culture: A method for culturing preadipocytes isolated ex vivo is described, the method including introducing preadipocytes into a three dimensional support matrix, and allowing the cells to differentiate in vitro into adipocytes within the support matrix. The matrix may be a collagen matrix. The method may be used for investigating the... Agent: Wolf Greenfield & Sacks, P.C.

20090221025 - Sensing device and method for rapidly determining concentrations of microbial organisms using interfacial photo-voltages: A system for detecting a wide range of microbial organisms, including virus, and determining concentrations in near real-time to determine titer, without the requirement to grow micro-organisms includes an electrometer configured to measure photo-induced interfacial voltages and an electrode assembly with a substrate and at least one electrode on a... Agent: Mark Young, P.A.

20090221026 - Novel microorganism and method for producing carotenoid using the same: To provide a microorganism capable of producing a large amount of carotenoids, mainly astaxanthin, and to provide a method of producing carotenoids using the microorganism, a microorganism having improved carotenoid productivity is used, which is obtainable by breeding a carotenoid producing Paracoccus bacteria which is featured by producing 720 mg... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090221032 - Entropic bristle domain sequences and their use in recombinant protein production: Compositions and methods for recombinant protein production and, more particularly, fusion polypeptides, polynucleotides encoding fusion polypeptides, expression vectors, kits, and related methods for recombinant protein production, are provided.... Agent: Seed Intellectual Property Law Group PLLC

20090221034 - Lipolytic enzyme variant with improved stability and polynucleotides encoding same: The invention provides lipolytic enzyme variants having improved in-detergent stability and polynucleotides encoding same. Lipolytic enzyme variants with improved in-detergent stability are obtained by substituting certain specified amino acid residues in a parent lipolytic enzyme.... Agent: Novozymes North America, Inc.

20090221031 - Novel group of esterases for the production of fine and speciality chemicals: The present invention relates to a polynucleotide encoding an enzyme having carboxyl esterase [E.C. 3.1.1.1] activity, wherein the coding sequence is selected from the group consisting of (a) a polynucleotide encoding an amino acid sequence as depicted in any one of SEQ ID NOs: 2, 4, 6 and 8; (b)... Agent: Pillsbury Winthrop Shaw Pittman LLP

20090221028 - Novel recombinant human hepatitis c virus-like particle and method for producing the same: The present invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising the steps of introducing into (i) a cell in which an RNA replicon comprising a nucleotide sequence comprising the 5′ untranslated region, the nucleotide sequence coding for the NS3, NS4A, NS4B, NS5A, and NS5B... Agent: Birch Stewart Kolasch & Birch

20090221029 - Pfu replication accessory factors and methods of use: This invention provides isolated polynucleotides that encode replication accessory factors. The invention also provides novel DNA replication accessory factors, which have been isolated and purified from the hyperthermophilic archaea Pyrococcus furiosus. The invention also provides various methods of enhancing a nucleic acid polymerase reaction comprising the addition of the replication... Agent: Agilent Techologies Inc

20090221033 - Polypeptides having lipase activity and polynucleotides encoding same: The invention provides polypeptides obtained by introducing mutations in one or more regions identified in a parent lipase. The polypeptides of the present invention have surprisingly been found to have a low specific activity towards short chain fatty acids leading to a reduced odor generation and an increased BR over... Agent: Novozymes North America, Inc.

20090221030 - Signal sequences and co-expressed chaperones for improving protein production in a host cell: The invention provides methods and compositions for improved protein production. The method comprises the steps of: (a) introducing into a host cell a first nucleic acid sequence comprising a signal sequence operably linked to a desired protein sequence; (b) expressing the first nucleic acid sequence; (c) co-expressing a second nucleic... Agent: Steven G. Bacsi Danisco US Inc. Genencor Division

20090221035 - Systems and methods for protein production: The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-engineered cells comprising one or more recombinant expression cassettes which encode (1) a protein of interest... Agent: Choate, Hall & Stewart LLP/wyeth

20090221027 - Use of a bacillus meti gene to improve methionine production in microorganisms: The present invention pertains to improved microorganisms and methods for the production of methionine and other sulfur containing fine chemicals using the metI gene from Bacillus subtilis or a gene related to metI. In some embodiments of the present invention, the metI gene or another gene is integrated in a... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090221036 - Recombinant anti-cd4 antibodies for human therapy: Chimeric antibodies specific to human CD4 antigen, DNA encoding, pharmaceutical compositions containing and use thereof as therapeutic agents are taught. These chimeric antibodies contain Old World monkey variable sequences and human constant domain sequences, preferably human gamma 1, gamma 4 or mutated forms thereof. These antibodies possess desirable therapeutic properties... Agent: Lahive & Cockfield, LLP / Biogen Idec Floor 30, Suite 3000

20090221037 - Fusion protein having the enhanced in vivo activity of erythropoietin: The present invention relates to a fusion protein in which a carboxy terminal of human erythropoietin (EPO) is fused with a carboxy terminal peptide fragment of β subunit of human chorionic gonadotropin (HCG), to DNA encoding the fusion protein, and to a method for preparation of the fusion protein. The... Agent: Peter F. Corless Dike, Bronstein, Roberts & Cushmam,IPGroup Of

20090221039 - Fusion proteins between plant cell-wall degrading enzymes and a swollenin, and their uses: The invention relates to fusion proteins including at least a swollenin and at least a plant cell-wall degrading enzyme, the swollenin, and plant cell-wall degrading enzyme, being recombinant proteins corresponding to native proteins in fungi, or mutated forms thereof. The invention also relates to the use of fusion proteins as... Agent: Young & Thompson

20090221038 - Twin-arginine translocation (tat) streptomyces signal sequences: Described herein are novel Tat signal polypeptides and methods for using the Tat signal polypeptides for producing heterologous polypeptides. A novel reporter assay for testing the biological activity of the secreted proteins is also described.... Agent: Elena E. Quertermous Genencor International

20090221040 - Antibodies active against a fusion polypeptide comprising a histidine portion: The present invention relates to an antibody active against a fusion polypeptide comprising a histidine portion, a process for the preparation thereof and its use.... Agent: Mcdermott Will & Emery LLP

20090221041 - Methods for starch hydrolysis: The presently disclosed subject matter provides a process for starch liquefaction using at least two classes of α-amylase enzymes, wherein the starch hydrolysis pattern from at least two of these classes is different. At least one class of enzyme is provided to the liquefaction process in the form of transgenic... Agent: Syngenta Biotechnology, Inc. Patent Department

20090221042 - Process for the treatment of lignocellulosic biomass: A process for the treatment of biomass to render structural carbohydrates more accessible and/or digestible using concentrated ammonium hydroxide with or without anhydrous ammonia addition, is described. The process preferably uses steam to strip ammonia from the biomass for recycling. The process yields of monosaccharides from the structural carbohydrates are... Agent: Ian C. Mcleod, P.C.

20090221043 - Mutant of the prob gene from coryneform bacteria: The invention relates to mutated variants of the proB gene from coryneform bacteria, which encode γ-glutamyl kinase, and to processes for fermentative production of L-proline using bacteria which contain this mutation.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090221044 - Process for the enantioselective enzymatic reduction of hydroxy keto compounds: e

20090221045 - Method for producing hydroxycarboxylic acid by enhancing synthesis of coenzyme: Hydroxycarboxylic acids are produced by using a microorganism that is improved in ability to produce nicotinamide adenine dinucleotide by deleting, mutating or substituting nadR gene in the microorganism or introducing a gene encoding nicotinic acid phosphoribosyltransferase.... Agent: Buchanan, Ingersoll & Rooney PC

20090221046 - Biocatalytic racemisation of alpha-hydroxyketones: A process for the racemisation of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of Lactobacillus.... Agent: Connolly Bove Lodge & Hutz, LLP

20090221047 - Web comprising fine fiber and bioactive particulate and uses thereof: The assemblies of the invention can comprise a fine fiber layer forming a multilamellar web or matrix, having dispersed within the fine fiber layer a bioactive particulate material, including cells, enzymes or microorganisms. Fluid that flows through the assemblies of the invention can have any material dispersed or dissolved in... Agent: Merchant & Gould PC

20090221049 - Thermophilic organisms for conversion of lignocellulosic biomass to ethanol: Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of Thermoanaerobacterium saccharolyticum with acetate kinase and phosphotransacetylase expression eliminated are disclosed herein. Further, strain ALK1 has been engineered by site directed homologous recombination to knockout both acetic acid and lactic acid production. Continuous culture... Agent: Lathrop & Gage LLP

20090221048 - Use of glucose isomerase mutants: This invention provides use of a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity obtained by using recombinant techniques. These mutants comprise at least one amino acid variation at position 87, position 139, position 182, position 187, position 217, position 260, position 276, or position 299, and... Agent: The Webb Law Firm, P.C.

20090221050 - Whole cell saccharification of lignocelluloses to sugars using a dual bioreactor system: The present invention describes a process for saccharification of lignocelluloses to sugars using whole microbial cells, which are enriched from cultures inoculated with paper mill waste water, wood processing waste and soil. A three-member bacterial consortium is selected as a potent microbial inocula and immobilized on inedible plant fibers for... Agent: Parviz Soroushian

20090221051 - Xylanases, nucleic acids encoding them and methods for making and using them: The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature.... Agent: Verenium C/o Mofo S.d.

20090221052 - Photosynthetic hydrogen production: A process for the production of hydrogen, comprising the steps of: (i) providing a photosynthetic microorganism having electron transfer capability through a photosynthetic “light” reaction pathway and through a respiratory electron transfer chain involving an oxidative phosphorylation pathway, and which expresses a hydrogenase, wherein regulation of the oxidative phosphorylation pathway... Agent: Moore & Van Allen PLLC

20090221053 - Sulfotransferase sequence variants: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to thyroid disease or cancer also are described.... Agent: Fish & Richardson P.C.

20090221054 - Biogas system: A biogas system includes a fermenter having a first fermenting chamber and a second fermenting chamber for the fermentation of a fermenting medium. Biogas formed in the first fermenting chamber can be introduced into a riser pipe disposed in the second fermenting chamber.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090221055 - Novel bacillus subtilis mutant strain: Novel Bacillus subtilis mutant strains having good productivity of various enzymes are provided through extensive analysis of strains that are derived from Bacillus subtilis via gene disruption. The Bacillus subtilis mutant strains according to the present invention have genomic structures prepared by deletion of regions listed in the columns for... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090221056 - Pathogen-detecting cell preservation systems: Methods to produce cells that remain viable at ambient or non-refrigerated temperatures, or which can be stored in a dry state are described. In particular, cell preservation is for long term storage of cells, such as mammalian cells, at ambient or non-refrigerated temperatures, while retaining cell viability. Also provided are... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090221057 - Bio-breeder system for biomass production: A system for converting flue gases into useful biofuels and oxygen. The system uses flue gases and thermal energy from smokestack industries to grow algae in a controlled environment. The flue gases are used as nutrients for the growth of algae through photosynthesis which is then processed into biofuels. The... Agent: Glenn L. Webb Glenn L. Webb P.C.

20090221058 - Potentiometric biosensor for detection of lactate in food and forming method thereof: The present invention discloses a potentiometric biosensor for detecting lactate in food, and the forming method thereof. The disclosed biosensor comprises a substrate, and conducting layer on the substrate, an oxide layer on the conducting layer, and an enzyme layer on the oxide layer, wherein the enzyme layer comprises Lactate... Agent: Wpat, PC

20090221059 - Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples: The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within... Agent: Fish & Richardson P.C.

20090221060 - Nucleic acid analyzer: It is an object of the present invention to prevent condensation occurring when reaction solutions in sealed vessels are heated in a nucleic acid analyzer for performing sequential processing in which individual reaction vessels are sequentially fed to a nucleic acid amplification unit in a given cycle. This invention relates... Agent: Mcdermott Will & Emery LLP

20090221061 - Array for rapid detection of a microorganism: A method for detecting a microorganism or class of microorganisms is provided. More specifically, the method employs an array that contains a plurality of discrete regions (referred to as “addresses”) spaced apart on a solid support in a predetermined pattern. The addresses are selected so that the array provides a... Agent: Dority & Manning, P.A.

20090221062 - Bio-composting domestic waste treatment apparatus, system and method of the same: A solid waste treatment apparatus and/or comprises a tank comprising an interior volume and an outlet and a liner comprising a floor and a plurality of upstanding exterior walls and at least one upstanding interior wall forming a first chamber and a second chamber in the liner. Each one of... Agent: Waters Law Group PLLC

20090221063 - Mobile modular, multi-chamber composting system: A mobile, modular multi-chamber composting system for the composting of organic material includes a composting unit having a pair of adjacent composting chambers enclosed by sidewalls, a roof, and closure panels, with the chambers delimited by a separation panel, and the first chamber having a uni-directional tilting floor and the... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20090221064 - Incubator for isolator: There is provided an incubator for an isolator, which is capable of reliably sterilizing a cultivation room of the incubator, a gas supply pipe and a sampling pipe. An incubator 1 for an isolator 40 includes a gas concentration control pipe 16 provided to communicate to a cultivation room 4... Agent: Kratz, Quintos & Hanson, LLP

20090221065 - Composition for suppressing the expression of fucosyltransferase: Disclosed is a means for reducing the expression amount of a FUT8 gene, reducing the expression amount of a FUT8 protein, and/or reducing the expression amount of a product produced by the action of FUT8.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090221066 - Anti-methylated dna antibody and method for production thereof: The present invention provides a method of preparing an anti-methylated DNA antibody, comprising a step of administering to an animal an oligodeoxyribonucleotide containing a methylated cytosine(s) and an oligodeoxyribonucleotide containing no methylated cytosine. The antibody prepared by this method is capable of detecting a DNA containing a methylated cytosine(s) in... Agent: Birch Stewart Kolasch & Birch

20090221067 - Cell lines that express hetero oligomeric taste receptors: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of... Agent: Hunton & Williams LLP Intellectual Property Department

20090221068 - Cell cultivation method and cell culture: Provided is a cell cultivation method in which the cell is cultured using a peptide hydrogel as a scaffold, for carrying out high-dimensional culture of a cell such as porcine hepatocyte, human hepatocyte, porcine pancreatic islet or human pancreatic islet for a long period under conditions where cell survival, cell... Agent: The Nath Law Group

20090221069 - Method for augmenting the ability of t-cells and other cells for fighting disease and invade diseased organs, for elevating cd3 zeta and tnf-alpha expression in t-cells, and mixing t-cell boosting and kit particularly useful in such method: A method and device for augmenting the ability of T-cells, NK cells and other body cells, of a patient for fighting disease and invading diseased tissue, and for elevating the level of CD3 zeta expression in T cells for better functioning of these T-cells and their augmented capability to eliminate... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090221070 - In vitro production of a cell population using feeder cells: A method for the in vitro production of a cell population P′ from a cell population P, the production requiring the presence of at least one factor which is expressed by feeder cells, wherein a) feeder cells proliferate at a temperature T1, b) proliferated feeder cells are contacted with the... Agent: Young & Thompson

20090221071 - Polyurea systems, processes for preparing the same and use thereof for postoperative adhesion barriers: wherein X represents an n-valent organic radical derived from a corresponding n-functional primary amine X(NH2)n, R1 and R2 each independently represent an organic radical having no Zerevitinov active hydrogens and n represents an integer of at least 2; and (b) an isocyanate functional prepolymer having a residual monomer content of... Agent: Connolly Bove Lodge & Hutz, LLP

20090221072 - Compositions and methods for modulating cell differentiation: Compositions and methods are described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I to inhibit hematopoiesis and to induce differentiation of neuroblastoma cells and neuronal stem cells.... Agent: Mccarter & English, LLP Hartford Cityplace I

20090221073 - Devices and methods for cell manipulation: Devices for fluid control and biological particle manipulation (e.g., cell enrichment and blood sampling) are disclosed. The devices a based on the ability to control the flow of fluids through the use of microfluidic valves. The valves are characterized, for example, by microstructures disposed on a mobile diaphragm.... Agent: Fish & Richardson PC

20090221074 - Materials and procedures for the purification of cells: The subject invention provides new materials and methods for the efficient isolation and purification of stem cells. Specifically, conductive immunopolymers with stem cell specific antibodies can be used to remove stem cells from biological fluids.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090221075 - System and process for separating a material: Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or... Agent: Harness, Dickey & Pierce, P.L.C

20090221076 - Method of fabricating sheet for cartilage tissue regeneration: An objective of the present invention is to provide a production method of a sheet for regenerating a cartilage tissue, which uses a conventional sheet-shaped porous body comprising a biological absorbency synthetic high polymer, such as polylactic acid, polyglycolic acid and a copolymer of lactic acid and glycolic acid. The... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090221077 - Process for producing cytotoxic lymphocytes: The present invention provides a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one step selected from induction, maintenance and expansion of a cytotoxic lymphocyte using a medium containing serum and plasma at a total concentration of 0% by... Agent: Birch Stewart Kolasch & Birch

20090221078 - Zymomonas with improved ethanol production in medium containing concentrated sugars and acetate: Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas further engineered to reduce activity of the himA gene were found to have increased ethanol production in comparison to a parental strain, when cultured... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

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